Queries 19001 to 20000

GO:0018024

tr|T1FXE7|T1FXE7_HELRO
Uncharacterized protein
Search

SLO-1

0.80	Calcium-activated BK potassium channel alpha subunit

0.73	GO:0071805	potassium ion transmembrane transport
0.48	GO:0043050	pharyngeal pumping
0.46	GO:0048149	behavioral response to ethanol
0.46	GO:0046928	regulation of neurotransmitter secretion
0.45	GO:0045214	sarcomere organization
0.40	GO:0040011	locomotion
0.34	GO:0034765	regulation of ion transmembrane transport
0.34	GO:0045892	negative regulation of transcription, DNA-templated

0.85	GO:0060072	large conductance calcium-activated potassium channel activity
0.74	GO:0005249	voltage-gated potassium channel activity
0.38	GO:0005515	protein binding
0.32	GO:0046872	metal ion binding

0.74	GO:0008076	voltage-gated potassium channel complex
0.46	GO:0055120	striated muscle dense body
0.46	GO:0031430	M band
0.43	GO:0045202	synapse
0.34	GO:0030054	cell junction
0.33	GO:0005634	nucleus

tr|T1FXE8|T1FXE8_HELRO
Uncharacterized protein
Search

ERCC1

0.67	Excision repair cross-complementing rodent repair deficiency complementation group 1

0.65	GO:0006281	DNA repair
0.64	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.48	GO:0006312	mitotic recombination
0.47	GO:0009411	response to UV
0.47	GO:0007127	meiosis I
0.46	GO:1904431	positive regulation of t-circle formation
0.46	GO:0090737	telomere maintenance via telomere trimming
0.46	GO:0001325	formation of extrachromosomal circular DNA
0.45	GO:1905764	regulation of protection from non-homologous end joining at telomere
0.45	GO:1904506	negative regulation of telomere maintenance in response to DNA damage

0.73	GO:0003684	damaged DNA binding
0.66	GO:0004519	endonuclease activity
0.45	GO:0001094	TFIID-class transcription factor binding
0.44	GO:0003697	single-stranded DNA binding
0.44	GO:0004536	deoxyribonuclease activity
0.43	GO:0008022	protein C-terminus binding
0.41	GO:0019904	protein domain specific binding
0.39	GO:0046982	protein heterodimerization activity
0.34	GO:0017025	TBP-class protein binding
0.34	GO:0004792	thiosulfate sulfurtransferase activity

0.61	GO:0005634	nucleus
0.45	GO:1990391	DNA repair complex
0.43	GO:0000781	chromosome, telomeric region
0.42	GO:0043234	protein complex
0.41	GO:0000428	DNA-directed RNA polymerase complex
0.41	GO:0070013	intracellular organelle lumen
0.40	GO:0005829	cytosol
0.32	GO:0005840	ribosome
0.30	GO:0016020	membrane

0.34	EC:2.8.1.1	GO:0004792
0.34	KEGG:R01931	GO:0004792

tr|T1FXE9|T1FXE9_HELRO
Uncharacterized protein
Search

0.47	GO:0046907	intracellular transport
0.45	GO:0034613	cellular protein localization
0.44	GO:0015031	protein transport
0.40	GO:0051647	nucleus localization
0.40	GO:2000574	regulation of microtubule motor activity
0.40	GO:0000132	establishment of mitotic spindle orientation
0.39	GO:0031023	microtubule organizing center organization
0.39	GO:0099111	microtubule-based transport
0.39	GO:0051650	establishment of vesicle localization
0.39	GO:0007281	germ cell development

0.52	GO:0003723	RNA binding
0.43	GO:0032559	adenyl ribonucleotide binding
0.43	GO:0008144	drug binding
0.43	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0070840	dynein complex binding
0.38	GO:0008017	microtubule binding
0.38	GO:0008289	lipid binding

0.40	GO:1904115	axon cytoplasm
0.39	GO:0000776	kinetochore
0.39	GO:0005813	centrosome
0.38	GO:0005875	microtubule associated complex
0.38	GO:0005938	cell cortex
0.38	GO:0005874	microtubule
0.37	GO:0005576	extracellular region
0.36	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0016020	membrane

tr|T1FXF0|T1FXF0_HELRO
Uncharacterized protein
Search

tr|T1FXF1|T1FXF1_HELRO
Uncharacterized protein
Search

TMEM161B

0.77	Transmembrane protein (Fragment)

0.36

GO:0015074

DNA integration

0.36	GO:0030554	adenyl nucleotide binding
0.35	GO:0097367	carbohydrate derivative binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003676	nucleic acid binding

0.30

GO:0031224

intrinsic component of membrane

tr|T1FXF2|T1FXF2_HELRO
Uncharacterized protein
Search

TRP-1

0.73	Transient receptor potential ion channel A

0.77	GO:0070588	calcium ion transmembrane transport
0.44	GO:0006828	manganese ion transport
0.44	GO:0051480	regulation of cytosolic calcium ion concentration
0.42	GO:0007338	single fertilization
0.40	GO:0008377	light-induced release of internally sequestered calcium ion
0.39	GO:0071454	cellular response to anoxia
0.39	GO:0008355	olfactory learning
0.39	GO:0050908	detection of light stimulus involved in visual perception
0.38	GO:0001895	retina homeostasis
0.38	GO:0007605	sensory perception of sound

0.80	GO:0005262	calcium channel activity
0.39	GO:0010461	light-activated ion channel activity
0.37	GO:0042803	protein homodimerization activity
0.37	GO:0046982	protein heterodimerization activity
0.34	GO:0003723	RNA binding
0.33	GO:0003735	structural constituent of ribosome
0.33	GO:0005516	calmodulin binding
0.32	GO:0016740	transferase activity

0.40	GO:0044459	plasma membrane part
0.40	GO:0035996	rhabdomere microvillus
0.37	GO:0034703	cation channel complex
0.37	GO:0019898	extrinsic component of membrane
0.35	GO:0098796	membrane protein complex
0.33	GO:0005840	ribosome

0.32

GO:0016740

tr|T1FXF3|T1FXF3_HELRO
Uncharacterized protein
Search

MRPL55

0.75	Mitochondrial ribosomal protein L55

0.47

GO:0006869

lipid transport

0.64

GO:0003735

structural constituent of ribosome

0.82

GO:0005762

mitochondrial large ribosomal subunit

tr|T1FXF4|T1FXF4_HELRO
S-methyl-5'-thioadenosine phosphorylase
Search

MTAP

0.66	S-methyl-5'-thioadenosine phosphorylase

0.71	GO:0006166	purine ribonucleoside salvage
0.70	GO:0019509	L-methionine salvage from methylthioadenosine
0.39	GO:0032259	methylation
0.37	GO:0070638	pyridine nucleoside catabolic process
0.37	GO:0046495	nicotinamide riboside metabolic process
0.35	GO:0035722	interleukin-12-mediated signaling pathway
0.35	GO:0033574	response to testosterone

0.81	GO:0017061	S-methyl-5-thioadenosine phosphorylase activity
0.34	GO:0004645	phosphorylase activity
0.33	GO:0005515	protein binding

0.58	GO:0005634	nucleus
0.46	GO:0005737	cytoplasm
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.81

EC:2.4.2.28

GO:0017061

tr|T1FXF5|T1FXF5_HELRO
Uncharacterized protein
Search

TSSK2

0.92	Testis-specific serine/threonine-protein kinase 1

0.63	GO:0006468	protein phosphorylation
0.51	GO:0007286	spermatid development
0.43	GO:0035556	intracellular signal transduction
0.37	GO:0043066	negative regulation of apoptotic process
0.37	GO:0007275	multicellular organism development
0.34	GO:0007528	neuromuscular junction development
0.33	GO:0030010	establishment of cell polarity
0.33	GO:0000226	microtubule cytoskeleton organization
0.32	GO:0006508	proteolysis

0.67	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0000287	magnesium ion binding
0.35	GO:0005515	protein binding
0.33	GO:0070001	aspartic-type peptidase activity
0.32	GO:0004175	endopeptidase activity

0.48	GO:0001669	acrosomal vesicle
0.47	GO:0005814	centriole
0.43	GO:0005634	nucleus
0.43	GO:0031514	motile cilium
0.30	GO:0031224	intrinsic component of membrane

0.67

GO:0004674

tr|T1FXF6|T1FXF6_HELRO
Uncharacterized protein
Search

tr|T1FXF7|T1FXF7_HELRO
Uncharacterized protein
Search

0.41	Voltage gated sodium channel (Fragment)

0.76	GO:0034765	regulation of ion transmembrane transport
0.76	GO:0035725	sodium ion transmembrane transport
0.35	GO:0050877	nervous system process
0.34	GO:0086010	membrane depolarization during action potential
0.34	GO:0035637	multicellular organismal signaling
0.32	GO:0007154	cell communication

0.83	GO:0005248	voltage-gated sodium channel activity
0.73	GO:0022832	voltage-gated channel activity
0.71	GO:0022839	ion gated channel activity
0.71	GO:0008381	mechanosensitive ion channel activity
0.68	GO:0005509	calcium ion binding

0.82

GO:0001518

voltage-gated sodium channel complex

tr|T1FXF8|T1FXF8_HELRO
Uncharacterized protein
Search

0.76	Mitochondrial import inner membrane translocase subunit TIM23

0.38	GO:0030150	protein import into mitochondrial matrix
0.33	GO:0006457	protein folding

0.34	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
0.34	GO:0051082	unfolded protein binding
0.33	GO:0042578	phosphoric ester hydrolase activity

0.39	GO:0005744	mitochondrial inner membrane presequence translocase complex
0.38	GO:0031305	integral component of mitochondrial inner membrane
0.34	GO:0016272	prefoldin complex

0.33

EC:3.1

GO:0042578

tr|T1FXF9|T1FXF9_HELRO
Uncharacterized protein
Search

0.67	Tropomyosin, variant

tr|T1FXG0|T1FXG0_HELRO
Uncharacterized protein
Search

0.38	Serine/threonine protein kinase

0.63	GO:0006468	protein phosphorylation
0.55	GO:0051172	negative regulation of nitrogen compound metabolic process
0.55	GO:0031324	negative regulation of cellular metabolic process
0.54	GO:0010605	negative regulation of macromolecule metabolic process
0.53	GO:0051348	negative regulation of transferase activity
0.53	GO:0009890	negative regulation of biosynthetic process
0.53	GO:0045859	regulation of protein kinase activity
0.52	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.52	GO:0045596	negative regulation of cell differentiation
0.51	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway

0.64	GO:0004672	protein kinase activity
0.59	GO:0003714	transcription corepressor activity
0.56	GO:0031434	mitogen-activated protein kinase kinase binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.54	GO:0055106	ubiquitin-protein transferase regulator activity
0.52	GO:0031625	ubiquitin protein ligase binding
0.49	GO:0004860	protein kinase inhibitor activity

0.46	GO:0005634	nucleus
0.42	GO:0012505	endomembrane system
0.42	GO:0070013	intracellular organelle lumen
0.40	GO:0031967	organelle envelope
0.40	GO:0031090	organelle membrane
0.39	GO:0043232	intracellular non-membrane-bounded organelle
0.37	GO:0005737	cytoplasm
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.33

EC:1.6.5.3

GO:0008137

tr|T1FXG1|T1FXG1_HELRO
Uncharacterized protein
Search

tr|T1FXG2|T1FXG2_HELRO
Uncharacterized protein
Search

PDIA6

0.83	Putative thioredoxin/protein disulfide isomerase

0.69	GO:0045454	cell redox homeostasis
0.45	GO:0043277	apoptotic cell clearance
0.43	GO:0034976	response to endoplasmic reticulum stress
0.40	GO:0006457	protein folding
0.39	GO:2000427	positive regulation of apoptotic cell clearance
0.37	GO:0055114	oxidation-reduction process
0.35	GO:0070527	platelet aggregation
0.34	GO:0034620	cellular response to unfolded protein
0.34	GO:0043687	post-translational protein modification
0.33	GO:0007017	microtubule-based process

0.63	GO:0016853	isomerase activity
0.47	GO:0015037	peptide disulfide oxidoreductase activity
0.38	GO:0140096	catalytic activity, acting on a protein
0.34	GO:0005200	structural constituent of cytoskeleton
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0032561	guanyl ribonucleotide binding
0.33	GO:0005515	protein binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.47	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.46	GO:0005783	endoplasmic reticulum
0.44	GO:0005615	extracellular space
0.43	GO:0005829	cytosol
0.36	GO:0042470	melanosome
0.35	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part
0.34	GO:1903561	extracellular vesicle
0.33	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.33	GO:0099512	supramolecular fiber

0.63

GO:0016853

tr|T1FXG3|T1FXG3_HELRO
Uncharacterized protein
Search

0.79	Hyperpolarization-activated cyclic nucleotide-modulated cation channel splice variant ABs-II

0.69	GO:0071805	potassium ion transmembrane transport
0.61	GO:0043269	regulation of ion transport
0.60	GO:0034762	regulation of transmembrane transport
0.47	GO:0016057	regulation of membrane potential in photoreceptor cell
0.47	GO:0007637	proboscis extension reflex
0.47	GO:0071632	optomotor response
0.47	GO:0050802	circadian sleep/wake cycle, sleep
0.46	GO:0071484	cellular response to light intensity
0.46	GO:0045938	positive regulation of circadian sleep/wake cycle, sleep
0.45	GO:0050433	regulation of catecholamine secretion

0.73	GO:0005249	voltage-gated potassium channel activity
0.35	GO:0004692	cGMP-dependent protein kinase activity
0.33	GO:0003677	DNA binding

0.35	GO:0005887	integral component of plasma membrane
0.33	GO:0005634	nucleus

0.35

EC:2.7.11.12

GO:0004692

tr|T1FXG4|T1FXG4_HELRO
Uncharacterized protein
Search

LRRC57

0.85	Leucine-rich repeat-containing protein 57

0.59	GO:0006171	cAMP biosynthetic process
0.51	GO:0016567	protein ubiquitination
0.50	GO:0035556	intracellular signal transduction
0.41	GO:0006468	protein phosphorylation
0.37	GO:0006470	protein dephosphorylation
0.36	GO:0030254	protein secretion by the type III secretion system
0.36	GO:0034052	positive regulation of plant-type hypersensitive response
0.36	GO:0070430	positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
0.35	GO:2000484	positive regulation of interleukin-8 secretion
0.35	GO:0009405	pathogenesis

0.59	GO:0004016	adenylate cyclase activity
0.51	GO:0004842	ubiquitin-protein transferase activity
0.50	GO:0000287	magnesium ion binding
0.42	GO:0016874	ligase activity
0.41	GO:0004672	protein kinase activity
0.38	GO:0032559	adenyl ribonucleotide binding
0.38	GO:0008144	drug binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0004721	phosphoprotein phosphatase activity
0.35	GO:0072542	protein phosphatase activator activity

0.42	GO:0070062	extracellular exosome
0.39	GO:0005622	intracellular
0.35	GO:0020002	host cell plasma membrane
0.35	GO:0030430	host cell cytoplasm
0.34	GO:0072357	PTW/PP1 phosphatase complex
0.30	GO:0016020	membrane

0.59	EC:4.6.1.1	GO:0004016
0.51	KEGG:R03876	GO:0004842

tr|T1FXG5|T1FXG5_HELRO
Uncharacterized protein
Search

0.50	Potassium voltage-gated channel protein Shaw

0.78	GO:0051260	protein homooligomerization
0.77	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.35	GO:0030431	sleep
0.34	GO:0006379	mRNA cleavage
0.32	GO:0006351	transcription, DNA-templated

0.78	GO:0005249	voltage-gated potassium channel activity
0.36	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.33	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.33	GO:0046872	metal ion binding
0.32	GO:0003676	nucleic acid binding

0.78

GO:0008076

voltage-gated potassium channel complex

0.36

EC:3.1.4.17

GO:0004114

tr|T1FXG6|T1FXG6_HELRO
Uncharacterized protein
Search

0.53	52 kDa repressor of the inhibitor of the protein kinase

0.57

GO:0016310

phosphorylation

0.68	GO:0046983	protein dimerization activity
0.59	GO:0016301	kinase activity

tr|T1FXG7|T1FXG7_HELRO
Uncharacterized protein
Search

0.81	GO:1904158	axonemal central apparatus assembly
0.77	GO:0060438	trachea development
0.77	GO:0021591	ventricular system development
0.74	GO:0003341	cilium movement
0.72	GO:0002064	epithelial cell development
0.38	GO:0032259	methylation

0.51	GO:0003774	motor activity
0.38	GO:0008168	methyltransferase activity

0.84	GO:1990718	axonemal central pair projection
0.53	GO:0016459	myosin complex
0.30	GO:0031224	intrinsic component of membrane

0.38

GO:0008168

tr|T1FXG8|T1FXG8_HELRO
Uncharacterized protein
Search

TBC1D1

0.64	TBC1 domain family member 1

0.79	GO:0031338	regulation of vesicle fusion
0.79	GO:0090630	activation of GTPase activity
0.65	GO:0006886	intracellular protein transport
0.55	GO:0032880	regulation of protein localization
0.52	GO:1902017	regulation of cilium assembly
0.44	GO:0032869	cellular response to insulin stimulus
0.41	GO:0061024	membrane organization
0.40	GO:0016192	vesicle-mediated transport

0.75	GO:0017137	Rab GTPase binding
0.75	GO:0005096	GTPase activator activity

0.63	GO:0012505	endomembrane system
0.48	GO:0005829	cytosol
0.42	GO:0005634	nucleus

tr|T1FXG9|T1FXG9_HELRO
Uncharacterized protein
Search

0.40	Tyrosine-protein kinase receptor

0.78	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.48	GO:0010966	regulation of phosphate transport
0.46	GO:0002066	columnar/cuboidal epithelial cell development
0.46	GO:0070372	regulation of ERK1 and ERK2 cascade
0.46	GO:0046777	protein autophosphorylation
0.45	GO:0007283	spermatogenesis
0.45	GO:0032006	regulation of TOR signaling
0.45	GO:0008283	cell proliferation
0.45	GO:0001558	regulation of cell growth

0.80	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0019903	protein phosphatase binding
0.37	GO:0042289	MHC class II protein binding
0.34	GO:0015321	sodium-dependent phosphate transmembrane transporter activity
0.33	GO:0008092	cytoskeletal protein binding

0.45	GO:0048471	perinuclear region of cytoplasm
0.44	GO:0009986	cell surface
0.35	GO:0005886	plasma membrane
0.33	GO:0005856	cytoskeleton
0.30	GO:0016021	integral component of membrane

0.80

EC:2.7.10.1

GO:0004714

tr|T1FXH0|T1FXH0_HELRO
Eukaryotic translation initiation factor 3 subunit A
Search

EIF3A

0.69	Eukaryotic translation initiation factor 3 subunit A

0.73	GO:0002183	cytoplasmic translational initiation
0.71	GO:0006446	regulation of translational initiation
0.68	GO:0022618	ribonucleoprotein complex assembly
0.56	GO:0075525	viral translational termination-reinitiation
0.55	GO:0075522	IRES-dependent viral translational initiation
0.37	GO:0070373	negative regulation of ERK1 and ERK2 cascade

0.72	GO:0003743	translation initiation factor activity
0.45	GO:0003729	mRNA binding
0.37	GO:0030971	receptor tyrosine kinase binding
0.33	GO:0005198	structural molecule activity

0.77	GO:0005852	eukaryotic translation initiation factor 3 complex
0.72	GO:0016282	eukaryotic 43S preinitiation complex
0.72	GO:0033290	eukaryotic 48S preinitiation complex
0.48	GO:0043614	multi-eIF complex
0.48	GO:0005730	nucleolus
0.46	GO:0005829	cytosol
0.36	GO:0005874	microtubule
0.34	GO:0005815	microtubule organizing center
0.30	GO:0016020	membrane

tr|T1FXH1|T1FXH1_HELRO
Uncharacterized protein
Search

0.65	Fas apoptotic inhibitory molecule

0.78

GO:0043066

negative regulation of apoptotic process

tr|T1FXH2|T1FXH2_HELRO
Uncharacterized protein
Search

tr|T1FXH3|T1FXH3_HELRO
Uncharacterized protein
Search

0.57	AMPactivated protein kinase beta subunit [Bombyx mori]

0.56	GO:0045859	regulation of protein kinase activity
0.53	GO:0016310	phosphorylation
0.48	GO:0007165	signal transduction

0.55

GO:0016301

kinase activity

0.62	GO:0031588	nucleotide-activated protein kinase complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1FXH4|T1FXH4_HELRO
Uncharacterized protein
Search

tr|T1FXH5|T1FXH5_HELRO
Uncharacterized protein
Search

MRPS14

0.95	Mitochondrial ribosomal protein S14

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.34	GO:0009083	branched-chain amino acid catabolic process
0.34	GO:0043624	cellular protein complex disassembly
0.32	GO:0055114	oxidation-reduction process

0.64	GO:0003735	structural constituent of ribosome
0.34	GO:0003826	alpha-ketoacid dehydrogenase activity
0.34	GO:0003863	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
0.33	GO:0003723	RNA binding
0.33	GO:0005515	protein binding
0.33	GO:0016746	transferase activity, transferring acyl groups
0.32	GO:0016787	hydrolase activity

0.61	GO:0005840	ribosome
0.50	GO:0005759	mitochondrial matrix
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0019866	organelle inner membrane
0.30	GO:0031224	intrinsic component of membrane

0.34

EC:1.2.4.4

GO:0003863

tr|T1FXH6|T1FXH6_HELRO
Carboxylic ester hydrolase
Search

0.27	Carboxylic ester hydrolase

0.52	GO:0050808	synapse organization
0.48	GO:0050804	modulation of chemical synaptic transmission
0.46	GO:0007155	cell adhesion
0.43	GO:0048488	synaptic vesicle endocytosis
0.38	GO:0071709	membrane assembly
0.38	GO:0007399	nervous system development
0.35	GO:1902805	positive regulation of synaptic vesicle transport
0.35	GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness
0.35	GO:0097091	synaptic vesicle clustering
0.35	GO:1900244	positive regulation of synaptic vesicle endocytosis

0.57	GO:0042043	neurexin family protein binding
0.47	GO:0016787	hydrolase activity
0.36	GO:0004872	receptor activity
0.34	GO:0097110	scaffold protein binding
0.34	GO:0030165	PDZ domain binding
0.34	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.34	GO:0020037	heme binding
0.34	GO:0005506	iron ion binding
0.33	GO:0004383	guanylate cyclase activity
0.33	GO:0030554	adenyl nucleotide binding

0.49	GO:0045202	synapse
0.44	GO:0005887	integral component of plasma membrane
0.38	GO:0009986	cell surface
0.33	GO:0097458	neuron part
0.33	GO:0098552	side of membrane
0.31	GO:0005622	intracellular

0.47

GO:0016787

tr|T1FXH7|T1FXH7_HELRO
Uncharacterized protein
Search

LIN52

0.97	Lin-52 DREAM MuvB core complex component

0.67	GO:0007049	cell cycle
0.58	GO:0006351	transcription, DNA-templated
0.34	GO:0051726	regulation of cell cycle
0.34	GO:0007275	multicellular organism development

0.86

GO:0070176

DRM complex

tr|T1FXH8|T1FXH8_HELRO
Peptidylprolyl isomerase
Search

0.17	Peptidylprolyl isomerase

0.72	GO:0000413	protein peptidyl-prolyl isomerization
0.34	GO:0006457	protein folding
0.33	GO:0016570	histone modification
0.33	GO:0006470	protein dephosphorylation

0.81	GO:0005528	FK506 binding
0.74	GO:0031072	heat shock protein binding
0.72	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.33	GO:0043022	ribosome binding
0.33	GO:0004721	phosphoprotein phosphatase activity
0.33	GO:0051082	unfolded protein binding

0.32	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.72

GO:0003755

tr|T1FXH9|T1FXH9_HELRO
Uncharacterized protein
Search

0.68	Serine and arginine rich splicing factor 7

0.44	GO:0048025	negative regulation of mRNA splicing, via spliceosome
0.43	GO:1990823	response to leukemia inhibitory factor
0.41	GO:0071345	cellular response to cytokine stimulus
0.40	GO:0008380	RNA splicing
0.36	GO:0051028	mRNA transport
0.35	GO:0006397	mRNA processing
0.34	GO:0006369	termination of RNA polymerase II transcription
0.34	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.33	GO:0031123	RNA 3'-end processing
0.33	GO:0006405	RNA export from nucleus

0.61	GO:0008270	zinc ion binding
0.59	GO:0003723	RNA binding
0.41	GO:0019904	protein domain specific binding

0.40	GO:0005654	nucleoplasm
0.34	GO:0070062	extracellular exosome
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1FXI0|T1FXI0_HELRO
Uncharacterized protein
Search

0.72	GO:0071805	potassium ion transmembrane transport
0.47	GO:0030322	stabilization of membrane potential
0.38	GO:0042321	negative regulation of circadian sleep/wake cycle, sleep
0.37	GO:0045837	negative regulation of membrane potential
0.37	GO:1903351	cellular response to dopamine
0.37	GO:0071467	cellular response to pH
0.33	GO:0006855	drug transmembrane transport

0.75	GO:0005267	potassium channel activity
0.44	GO:0022842	narrow pore channel activity
0.41	GO:0022843	voltage-gated cation channel activity
0.36	GO:0005227	calcium activated cation channel activity
0.33	GO:0015238	drug transmembrane transporter activity
0.33	GO:0099094	ligand-gated cation channel activity

0.39

GO:0005887

integral component of plasma membrane

tr|T1FXI1|T1FXI1_HELRO
Uncharacterized protein
Search

0.51	Mitochondrial transport

0.61	GO:0006839	mitochondrial transport
0.47	GO:0055085	transmembrane transport
0.45	GO:0030302	deoxynucleotide transport
0.44	GO:0006390	mitochondrial transcription
0.42	GO:0048311	mitochondrion distribution
0.39	GO:0006864	pyrimidine nucleotide transport
0.38	GO:0040011	locomotion
0.37	GO:0045333	cellular respiration
0.36	GO:1990314	cellular response to insulin-like growth factor stimulus
0.36	GO:0002082	regulation of oxidative phosphorylation

0.39	GO:0015218	pyrimidine nucleotide transmembrane transporter activity
0.33	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.32	GO:0008270	zinc ion binding

0.51	GO:0031966	mitochondrial membrane
0.35	GO:0019866	organelle inner membrane
0.32	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

tr|T1FXI2|T1FXI2_HELRO
Uncharacterized protein
Search

RHOT1

0.70	Mitochondrial Rho GTPase

0.73	GO:0007005	mitochondrion organization
0.50	GO:1905710	positive regulation of membrane permeability
0.50	GO:0047497	mitochondrion transport along microtubule
0.47	GO:0097190	apoptotic signaling pathway
0.46	GO:0006839	mitochondrial transport
0.43	GO:0019725	cellular homeostasis
0.43	GO:0061024	membrane organization
0.39	GO:0034640	establishment of mitochondrion localization by microtubule attachment
0.38	GO:1902513	regulation of organelle transport along microtubule
0.37	GO:0046928	regulation of neurotransmitter secretion

0.69	GO:0005509	calcium ion binding
0.67	GO:0003924	GTPase activity
0.65	GO:0001883	purine nucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.64	GO:0032549	ribonucleoside binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding

0.80	GO:0031307	integral component of mitochondrial outer membrane
0.37	GO:0005829	cytosol
0.32	GO:0005886	plasma membrane

tr|T1FXI3|T1FXI3_HELRO
Uncharacterized protein
Search

PAPOLG

0.85	Poly polymerase gamma

0.80	GO:0043631	RNA polyadenylation
0.76	GO:0031123	RNA 3'-end processing
0.37	GO:0006397	mRNA processing

0.78	GO:0004652	polynucleotide adenylyltransferase activity
0.59	GO:0003723	RNA binding
0.51	GO:0030554	adenyl nucleotide binding
0.50	GO:0046872	metal ion binding
0.50	GO:0097367	carbohydrate derivative binding
0.50	GO:0008144	drug binding
0.50	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005634	nucleus
0.33	GO:0005829	cytosol
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.78

EC:2.7.7.19

GO:0004652

tr|T1FXI4|T1FXI4_HELRO
Uncharacterized protein
Search

0.78	GO:0035023	regulation of Rho protein signal transduction
0.66	GO:0065009	regulation of molecular function
0.61	GO:0035556	intracellular signal transduction
0.34	GO:0048522	positive regulation of cellular process
0.33	GO:0019216	regulation of lipid metabolic process
0.33	GO:0006452	translational frameshifting
0.33	GO:0006449	regulation of translational termination
0.33	GO:0042981	regulation of apoptotic process
0.33	GO:0006448	regulation of translational elongation
0.33	GO:0007186	G-protein coupled receptor signaling pathway

0.78	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.60	GO:0005057	signal transducer activity, downstream of receptor
0.45	GO:0005096	GTPase activator activity
0.33	GO:0043022	ribosome binding
0.33	GO:0003746	translation elongation factor activity

0.45	GO:0005622	intracellular
0.35	GO:0030175	filopodium
0.35	GO:0030426	growth cone
0.35	GO:0030027	lamellipodium
0.35	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

tr|T1FXI5|T1FXI5_HELRO
Uncharacterized protein
Search

0.37	Triacylglycerol lipase

0.57	GO:0006629	lipid metabolic process
0.44	GO:1901575	organic substance catabolic process
0.36	GO:0006968	cellular defense response
0.36	GO:0007586	digestion

0.69	GO:0052689	carboxylic ester hydrolase activity
0.53	GO:0016298	lipase activity

0.65	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.69	EC:3.1.1 EC:3.1.1.1	GO:0052689
0.69	KEGG:R00630	GO:0052689

tr|T1FXI6|T1FXI6_HELRO
Uncharacterized protein
Search

0.82	GO:0002244	hematopoietic progenitor cell differentiation
0.39	GO:0060271	cilium assembly
0.38	GO:0016055	Wnt signaling pathway

0.39	GO:0005813	centrosome
0.36	GO:0005634	nucleus

tr|T1FXI7|T1FXI7_HELRO
Uncharacterized protein
Search

0.61	Serine/threonine-protein kinase PAK

0.63	GO:0006468	protein phosphorylation
0.46	GO:0043067	regulation of programmed cell death
0.42	GO:0007266	Rho protein signal transduction
0.42	GO:0030036	actin cytoskeleton organization
0.42	GO:0051960	regulation of nervous system development
0.41	GO:0031098	stress-activated protein kinase signaling cascade
0.41	GO:0032147	activation of protein kinase activity
0.41	GO:0007520	myoblast fusion
0.41	GO:0043408	regulation of MAPK cascade
0.40	GO:0016477	cell migration

0.64	GO:0004672	protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0048365	Rac GTPase binding
0.39	GO:0042803	protein homodimerization activity
0.37	GO:0005057	signal transducer activity, downstream of receptor
0.35	GO:0031435	mitogen-activated protein kinase kinase kinase binding
0.34	GO:0017124	SH3 domain binding

0.41	GO:0031941	filamentous actin
0.40	GO:0001726	ruffle
0.35	GO:0005737	cytoplasm
0.35	GO:0120038	plasma membrane bounded cell projection part
0.35	GO:0097482	muscle cell postsynaptic specialization
0.34	GO:0043204	perikaryon
0.34	GO:0016328	lateral plasma membrane
0.34	GO:0000131	incipient cellular bud site
0.34	GO:0070938	contractile ring
0.34	GO:0051286	cell tip

tr|T1FXI8|T1FXI8_HELRO
Uncharacterized protein
Search

CDC6

0.69	Cell division control protein 6

0.70	GO:0006270	DNA replication initiation
0.63	GO:0051301	cell division
0.49	GO:0032467	positive regulation of cytokinesis
0.48	GO:0051984	positive regulation of chromosome segregation
0.47	GO:0030071	regulation of mitotic metaphase/anaphase transition
0.45	GO:0000278	mitotic cell cycle
0.39	GO:1904117	cellular response to vasopressin
0.38	GO:1904385	cellular response to angiotensin
0.38	GO:0048146	positive regulation of fibroblast proliferation
0.37	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity

0.46	GO:0019900	kinase binding
0.45	GO:0032559	adenyl ribonucleotide binding
0.44	GO:0008144	drug binding
0.44	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0003779	actin binding
0.32	GO:0004674	protein serine/threonine kinase activity

0.57	GO:0005634	nucleus
0.48	GO:0051233	spindle midzone
0.47	GO:0000922	spindle pole
0.34	GO:0043233	organelle lumen
0.33	GO:0005829	cytosol
0.33	GO:0000785	chromatin

0.32

GO:0004674

tr|T1FXI9|T1FXI9_HELRO
Uncharacterized protein
Search

VAC14

0.94	Vacuole morphology and inheritance protein 14

0.78	GO:0006661	phosphatidylinositol biosynthetic process
0.36	GO:0097178	ruffle assembly
0.36	GO:0007009	plasma membrane organization
0.34	GO:0006970	response to osmotic stress
0.34	GO:0042327	positive regulation of phosphorylation
0.33	GO:0016032	viral process
0.33	GO:0007165	signal transduction
0.32	GO:0008033	tRNA processing

0.35	GO:0003779	actin binding
0.35	GO:0019209	kinase activator activity
0.33	GO:0004872	receptor activity
0.32	GO:0016783	sulfurtransferase activity

0.85	GO:0070772	PAS complex
0.54	GO:0010008	endosome membrane
0.37	GO:0005783	endoplasmic reticulum
0.35	GO:0005770	late endosome
0.35	GO:0005769	early endosome
0.34	GO:0000139	Golgi membrane
0.30	GO:0031224	intrinsic component of membrane

0.32

EC:2.8.1

GO:0016783

tr|T1FXJ0|T1FXJ0_HELRO
Uncharacterized protein
Search

tr|T1FXJ1|T1FXJ1_HELRO
Uncharacterized protein
Search

0.69	GO:0045454	cell redox homeostasis
0.58	GO:0006662	glycerol ether metabolic process
0.55	GO:0006228	UTP biosynthetic process
0.55	GO:0006183	GTP biosynthetic process
0.53	GO:0046036	CTP metabolic process
0.53	GO:0006165	nucleoside diphosphate phosphorylation
0.49	GO:0030317	flagellated sperm motility
0.48	GO:0060271	cilium assembly
0.46	GO:0034599	cellular response to oxidative stress
0.45	GO:0000302	response to reactive oxygen species

0.58	GO:0004550	nucleoside diphosphate kinase activity
0.56	GO:0015035	protein disulfide oxidoreductase activity
0.46	GO:0008017	microtubule binding
0.35	GO:0047134	protein-disulfide reductase activity
0.34	GO:0030246	carbohydrate binding
0.34	GO:0004791	thioredoxin-disulfide reductase activity
0.34	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

0.51	GO:0036157	outer dynein arm
0.51	GO:0097598	sperm cytoplasmic droplet
0.49	GO:0097228	sperm principal piece
0.33	GO:0005739	mitochondrion
0.33	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.58	EC:2.7.4.6	GO:0004550
0.34	KEGG:R02016	GO:0004791

tr|T1FXJ2|T1FXJ2_HELRO
Uncharacterized protein
Search

tr|T1FXJ3|T1FXJ3_HELRO
DIS3-like exonuclease 2
Search

DIS3L2

0.76	DIS3 like 3'-5' exoribonuclease 2

0.80	GO:0010587	miRNA catabolic process
0.69	GO:0051306	mitotic sister chromatid separation
0.67	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
0.65	GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic
0.64	GO:0019827	stem cell population maintenance
0.61	GO:0008285	negative regulation of cell proliferation
0.57	GO:0048793	pronephros development
0.57	GO:0006364	rRNA processing
0.47	GO:0006914	autophagy

0.71	GO:0000175	3'-5'-exoribonuclease activity
0.66	GO:0008266	poly(U) RNA binding
0.52	GO:0000287	magnesium ion binding

0.72	GO:0000932	P-body
0.65	GO:0000178	exosome (RNase complex)

0.71

EC:3.1.13

GO:0000175

tr|T1FXJ4|T1FXJ4_HELRO
Synaptotagmin 4
Search

0.68	Synaptotagmin IV

0.54	GO:0099643	signal release from synapse
0.54	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.51	GO:0006836	neurotransmitter transport
0.51	GO:0001505	regulation of neurotransmitter levels
0.48	GO:0051649	establishment of localization in cell
0.46	GO:1903530	regulation of secretion by cell
0.45	GO:0060627	regulation of vesicle-mediated transport
0.45	GO:0006887	exocytosis
0.44	GO:0051588	regulation of neurotransmitter transport
0.43	GO:0050804	modulation of chemical synaptic transmission

0.56	GO:0005544	calcium-dependent phospholipid binding
0.46	GO:0000149	SNARE binding
0.43	GO:0001786	phosphatidylserine binding
0.40	GO:0030276	clathrin binding
0.38	GO:0005509	calcium ion binding
0.37	GO:0048487	beta-tubulin binding
0.37	GO:0031369	translation initiation factor binding
0.37	GO:0031625	ubiquitin protein ligase binding
0.36	GO:0042803	protein homodimerization activity
0.34	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity

0.53	GO:0044456	synapse part
0.52	GO:0070382	exocytic vesicle
0.52	GO:0097458	neuron part
0.42	GO:0031594	neuromuscular junction
0.42	GO:0016324	apical plasma membrane
0.38	GO:0032009	early phagosome
0.38	GO:0001891	phagocytic cup
0.37	GO:0055037	recycling endosome
0.37	GO:0005764	lysosome
0.36	GO:0120025	plasma membrane bounded cell projection

0.34	EC:2.7.1.154	GO:0035005
0.34	KEGG:R05795	GO:0035005

tr|T1FXJ5|T1FXJ5_HELRO
Uncharacterized protein
Search

PAK4

0.46	Serine/threonine-protein kinase PAK 4

0.63	GO:0006468	protein phosphorylation
0.48	GO:0060996	dendritic spine development
0.48	GO:2000352	negative regulation of endothelial cell apoptotic process
0.48	GO:0007010	cytoskeleton organization
0.48	GO:0016049	cell growth
0.47	GO:0051094	positive regulation of developmental process
0.47	GO:0051240	positive regulation of multicellular organismal process
0.47	GO:0006915	apoptotic process
0.46	GO:2000026	regulation of multicellular organismal development
0.45	GO:0071407	cellular response to organic cyclic compound

0.64	GO:0004672	protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0098641	cadherin binding involved in cell-cell adhesion
0.45	GO:0048365	Rac GTPase binding
0.34	GO:0031435	mitogen-activated protein kinase kinase kinase binding
0.33	GO:0005057	signal transducer activity, downstream of receptor
0.32	GO:0046872	metal ion binding

0.49	GO:0005913	cell-cell adherens junction
0.36	GO:0005737	cytoplasm
0.35	GO:0005886	plasma membrane
0.35	GO:0005925	focal adhesion
0.33	GO:0043204	perikaryon
0.33	GO:0030425	dendrite
0.33	GO:0012505	endomembrane system
0.32	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

tr|T1FXJ6|T1FXJ6_HELRO
Uncharacterized protein
Search

0.40	Zinc finger MYM-type protein 1

0.68

GO:0046983

protein dimerization activity

tr|T1FXJ7|T1FXJ7_HELRO
Uncharacterized protein
Search

PPP1R7

0.87	Phosphatase 1 regulatory subunit 7

0.75	GO:0035307	positive regulation of protein dephosphorylation
0.68	GO:0007059	chromosome segregation
0.53	GO:0043666	regulation of phosphoprotein phosphatase activity
0.52	GO:0051457	maintenance of protein location in nucleus
0.50	GO:0035308	negative regulation of protein dephosphorylation
0.50	GO:0010923	negative regulation of phosphatase activity
0.45	GO:0061588	calcium activated phospholipid scrambling
0.42	GO:0045842	positive regulation of mitotic metaphase/anaphase transition

0.56	GO:0072542	protein phosphatase activator activity
0.52	GO:0004865	protein serine/threonine phosphatase inhibitor activity
0.41	GO:0005515	protein binding

0.60	GO:0005694	chromosome
0.51	GO:0008287	protein serine/threonine phosphatase complex
0.48	GO:0005634	nucleus
0.40	GO:0044444	cytoplasmic part
0.39	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

tr|T1FXJ8|T1FXJ8_HELRO
Bestrophin homolog
Search

0.63	Bestrophin

0.74	GO:1902476	chloride transmembrane transport
0.45	GO:0009992	cellular water homeostasis
0.40	GO:0007601	visual perception
0.36	GO:0051899	membrane depolarization
0.35	GO:0007608	sensory perception of smell
0.34	GO:0045332	phospholipid translocation
0.32	GO:0055114	oxidation-reduction process

0.75	GO:0005254	chloride channel activity
0.44	GO:0005225	volume-sensitive anion channel activity
0.40	GO:0022839	ion gated channel activity
0.40	GO:0008381	mechanosensitive ion channel activity
0.34	GO:0004012	phospholipid-translocating ATPase activity
0.33	GO:0000287	magnesium ion binding
0.33	GO:0010181	FMN binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.78	GO:0034707	chloride channel complex
0.54	GO:0005886	plasma membrane
0.35	GO:0005929	cilium

0.34

GO:0004012

tr|T1FXJ9|T1FXJ9_HELRO
Uncharacterized protein
Search

0.51	GO:0016579	protein deubiquitination
0.49	GO:0006259	DNA metabolic process
0.42	GO:0034654	nucleobase-containing compound biosynthetic process
0.41	GO:0009059	macromolecule biosynthetic process

0.51	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.48	GO:0003964	RNA-directed DNA polymerase activity
0.39	GO:0003676	nucleic acid binding

0.30

GO:0031224

intrinsic component of membrane

0.51

GO:0036459

tr|T1FXK0|T1FXK0_HELRO
Uncharacterized protein
Search

0.28	DNA mismatch repair protein MutT

0.38	GO:0009132	nucleoside diphosphate metabolic process
0.33	GO:0006508	proteolysis

0.51	GO:0016787	hydrolase activity
0.39	GO:0030145	manganese ion binding
0.37	GO:0000287	magnesium ion binding
0.33	GO:0140096	catalytic activity, acting on a protein

0.30

GO:0031224

intrinsic component of membrane

0.51

GO:0016787

tr|T1FXK1|T1FXK1_HELRO
Uncharacterized protein
Search

0.53	FMRFamide receptor

0.71

GO:0007186

G-protein coupled receptor signaling pathway

0.79

GO:0008528

G-protein coupled peptide receptor activity

0.30

GO:0044425

membrane part

tr|T1FXK2|T1FXK2_HELRO
Uncharacterized protein
Search

0.37	Transposase (Fragment)

tr|T1FXK3|T1FXK3_HELRO
Uncharacterized protein
Search

QARS

0.47	Glutaminyl-tRNA synthetase

0.81	GO:0006425	glutaminyl-tRNA aminoacylation
0.43	GO:0048813	dendrite morphogenesis
0.39	GO:0006886	intracellular protein transport
0.36	GO:0032873	negative regulation of stress-activated MAPK cascade
0.36	GO:2001234	negative regulation of apoptotic signaling pathway
0.36	GO:0006469	negative regulation of protein kinase activity
0.35	GO:0007420	brain development
0.35	GO:0000413	protein peptidyl-prolyl isomerization
0.35	GO:0045892	negative regulation of transcription, DNA-templated
0.33	GO:0001522	pseudouridine synthesis

0.81	GO:0004819	glutamine-tRNA ligase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0004860	protein kinase inhibitor activity
0.35	GO:0019901	protein kinase binding
0.35	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.33	GO:0009982	pseudouridine synthase activity
0.32	GO:0003723	RNA binding

0.49	GO:0005737	cytoplasm
0.45	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex
0.30	GO:0016020	membrane

0.81

EC:6.1.1.18

GO:0004819

tr|T1FXK4|T1FXK4_HELRO
Uncharacterized protein
Search

0.52	GO:0007165	signal transduction
0.42	GO:0072659	protein localization to plasma membrane
0.41	GO:0006888	ER to Golgi vesicle-mediated transport
0.41	GO:0035220	wing disc development
0.40	GO:2001252	positive regulation of chromosome organization
0.40	GO:0007450	dorsal/ventral pattern formation, imaginal disc
0.39	GO:2000573	positive regulation of DNA biosynthetic process
0.39	GO:0032210	regulation of telomere maintenance via telomerase
0.39	GO:0032846	positive regulation of homeostatic process
0.39	GO:0051225	spindle assembly

0.43	GO:0008093	cytoskeletal adaptor activity
0.43	GO:0051117	ATPase binding
0.43	GO:0030507	spectrin binding
0.39	GO:0003950	NAD+ ADP-ribosyltransferase activity
0.38	GO:0018024	histone-lysine N-methyltransferase activity
0.36	GO:0008270	zinc ion binding
0.34	GO:0097718	disordered domain specific binding
0.34	GO:0005216	ion channel activity
0.34	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.33	GO:0042802	identical protein binding

0.44	GO:0014731	spectrin-associated cytoskeleton
0.37	GO:0005705	polytene chromosome interband
0.36	GO:0005634	nucleus
0.36	GO:0016529	sarcoplasmic reticulum
0.36	GO:0000791	euchromatin
0.36	GO:0005886	plasma membrane
0.35	GO:0031430	M band
0.35	GO:0044304	main axon
0.35	GO:0030018	Z disc
0.35	GO:0030863	cortical cytoskeleton

0.39

EC:2.4.2.30

GO:0003950

tr|T1FXK5|T1FXK5_HELRO
Uncharacterized protein
Search

0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.42	GO:0014017	neuroblast fate commitment
0.40	GO:0050773	regulation of dendrite development
0.39	GO:0008285	negative regulation of cell proliferation
0.34	GO:0045664	regulation of neuron differentiation
0.34	GO:0030334	regulation of cell migration

0.51	GO:0003676	nucleic acid binding
0.37	GO:0003700	DNA binding transcription factor activity
0.33	GO:0046872	metal ion binding

0.37	GO:0005634	nucleus
0.30	GO:0044425	membrane part

tr|T1FXK6|T1FXK6_HELRO
Uncharacterized protein
Search

MINDY3

0.79	Ubiquitin carboxyl-terminal hydrolase MINDY-3

0.65	GO:0071108	protein K48-linked deubiquitination
0.43	GO:0006915	apoptotic process
0.33	GO:0006397	mRNA processing

0.70	GO:0070004	cysteine-type exopeptidase activity
0.65	GO:1990380	Lys48-specific deubiquitinase activity
0.60	GO:0005509	calcium ion binding
0.57	GO:0004180	carboxypeptidase activity
0.42	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.34	GO:0005515	protein binding

0.61	GO:0031965	nuclear membrane
0.55	GO:0005654	nucleoplasm
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0031224	intrinsic component of membrane

0.42

GO:0036459

tr|T1FXK7|T1FXK7_HELRO
Uncharacterized protein
Search

TTLL5

0.57	Tubulin tyrosine ligase like 5

0.60	GO:0036211	protein modification process
0.56	GO:0044267	cellular protein metabolic process
0.50	GO:0007288	sperm axoneme assembly
0.48	GO:0060041	retina development in camera-type eye
0.48	GO:0009566	fertilization
0.34	GO:0006351	transcription, DNA-templated
0.33	GO:0055085	transmembrane transport

0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0070740	tubulin-glutamic acid ligase activity
0.34	GO:0070735	protein-glycine ligase activity
0.33	GO:0022857	transmembrane transporter activity

0.47	GO:0005929	cilium
0.46	GO:0005813	centrosome
0.43	GO:0005829	cytosol
0.39	GO:0005886	plasma membrane
0.37	GO:0005874	microtubule
0.36	GO:0030991	intraciliary transport particle A
0.35	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.45

EC:6.3.2

GO:0070740

tr|T1FXK8|T1FXK8_HELRO
ER lumen protein-retaining receptor
Search

0.66	ER lumen protein-retaining receptor

0.84	GO:0006621	protein retention in ER lumen
0.65	GO:0015031	protein transport
0.39	GO:0016192	vesicle-mediated transport
0.35	GO:0002369	T cell cytokine production
0.35	GO:0036498	IRE1-mediated unfolded protein response
0.35	GO:0070231	T cell apoptotic process
0.34	GO:0030217	T cell differentiation
0.33	GO:0046907	intracellular transport
0.33	GO:0006629	lipid metabolic process

0.84	GO:0046923	ER retention sequence binding
0.32	GO:0003676	nucleic acid binding
0.32	GO:0016787	hydrolase activity

0.72	GO:0005789	endoplasmic reticulum membrane
0.38	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.37	GO:0031410	cytoplasmic vesicle
0.37	GO:0098588	bounding membrane of organelle
0.36	GO:0012506	vesicle membrane
0.36	GO:0005801	cis-Golgi network
0.35	GO:0098805	whole membrane
0.35	GO:0005794	Golgi apparatus
0.34	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016787

tr|T1FXK9|T1FXK9_HELRO
Uncharacterized protein
Search

0.10	Zinc finger CCCH-type containing 12D (Fragment)

0.46	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
0.45	GO:0034644	cellular response to UV
0.45	GO:0031397	negative regulation of protein ubiquitination
0.38	GO:0061158	3'-UTR-mediated mRNA destabilization
0.36	GO:2000625	regulation of miRNA catabolic process
0.36	GO:1904636	response to ionomycin
0.36	GO:0006402	mRNA catabolic process
0.36	GO:1903936	cellular response to sodium arsenite
0.36	GO:0071362	cellular response to ether
0.36	GO:1902714	negative regulation of interferon-gamma secretion

0.50	GO:0046872	metal ion binding
0.39	GO:0003723	RNA binding
0.35	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.35	GO:0003682	chromatin binding
0.34	GO:0004532	exoribonuclease activity
0.34	GO:0004519	endonuclease activity
0.34	GO:0043022	ribosome binding
0.33	GO:0003677	DNA binding
0.32	GO:0005515	protein binding

0.45	GO:0016605	PML body
0.42	GO:0005730	nucleolus
0.40	GO:0000932	P-body
0.36	GO:0042406	extrinsic component of endoplasmic reticulum membrane
0.35	GO:0005791	rough endoplasmic reticulum
0.34	GO:0005856	cytoskeleton
0.33	GO:0043234	protein complex

tr|T1FXL0|T1FXL0_HELRO
Uncharacterized protein
Search

WDR11

0.96	Bromodomain and WD repeat-containing protein 2

0.36	GO:0005515	protein binding
0.30	GO:0003824	catalytic activity

0.68	GO:0015630	microtubule cytoskeleton
0.66	GO:0005829	cytosol
0.48	GO:0005765	lysosomal membrane
0.42	GO:0005929	cilium
0.38	GO:0005634	nucleus
0.30	GO:0044425	membrane part

tr|T1FXL1|T1FXL1_HELRO
Uncharacterized protein
Search

TSSK2

0.78	Testis-specific serine/threonine-protein kinase

0.63	GO:0006468	protein phosphorylation
0.50	GO:0007286	spermatid development
0.46	GO:0035556	intracellular signal transduction
0.39	GO:0033129	positive regulation of histone phosphorylation
0.39	GO:0051091	positive regulation of DNA binding transcription factor activity
0.39	GO:0070498	interleukin-1-mediated signaling pathway
0.38	GO:0018209	peptidyl-serine modification
0.38	GO:0035066	positive regulation of histone acetylation
0.37	GO:0016570	histone modification
0.37	GO:0048523	negative regulation of cellular process

0.67	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.47	GO:0000287	magnesium ion binding
0.35	GO:0005509	calcium ion binding
0.35	GO:0005515	protein binding
0.33	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.33	GO:0015098	molybdate ion transmembrane transporter activity

0.47	GO:0001669	acrosomal vesicle
0.45	GO:0005814	centriole
0.43	GO:0005634	nucleus
0.42	GO:0031514	motile cilium
0.36	GO:0070013	intracellular organelle lumen
0.30	GO:0016020	membrane

0.67

GO:0004674

tr|T1FXL2|T1FXL2_HELRO
Uncharacterized protein
Search

0.79	GO:0010923	negative regulation of phosphatase activity
0.54	GO:0035308	negative regulation of protein dephosphorylation
0.53	GO:0043666	regulation of phosphoprotein phosphatase activity
0.42	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
0.42	GO:0043488	regulation of mRNA stability
0.40	GO:0017148	negative regulation of translation
0.37	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.36	GO:0007186	G-protein coupled receptor signaling pathway
0.35	GO:0035556	intracellular signal transduction

0.55	GO:0004864	protein phosphatase inhibitor activity
0.43	GO:0030371	translation repressor activity
0.42	GO:0019902	phosphatase binding
0.40	GO:0003729	mRNA binding
0.35	GO:0004871	signal transducer activity

0.41	GO:0000932	P-body
0.37	GO:1905360	GTPase complex
0.37	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.35	GO:0098797	plasma membrane protein complex
0.30	GO:0016021	integral component of membrane

tr|T1FXL3|T1FXL3_HELRO
Uncharacterized protein
Search

CSNK1A1

0.68	Casein kinase 1 protein catalytic subunit

0.63	GO:0006468	protein phosphorylation
0.44	GO:0018209	peptidyl-serine modification
0.44	GO:0016055	Wnt signaling pathway
0.43	GO:0006909	phagocytosis
0.41	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.40	GO:0051128	regulation of cellular component organization
0.40	GO:0022603	regulation of anatomical structure morphogenesis
0.40	GO:0032886	regulation of microtubule-based process
0.39	GO:0007346	regulation of mitotic cell cycle
0.39	GO:0010564	regulation of cell cycle process

0.67	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0004610	phosphoacetylglucosamine mutase activity
0.34	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.34	GO:0005057	signal transducer activity, downstream of receptor
0.33	GO:0000287	magnesium ion binding

0.40	GO:0005813	centrosome
0.40	GO:0005634	nucleus
0.36	GO:0005737	cytoplasm
0.34	GO:0036064	ciliary basal body
0.34	GO:0045095	keratin filament
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0031984	organelle subcompartment
0.33	GO:0012505	endomembrane system
0.33	GO:0031974	membrane-enclosed lumen
0.33	GO:0030529	intracellular ribonucleoprotein complex

0.67	EC:2.7.11	GO:0004674
0.37	KEGG:R08193	GO:0004610

tr|T1FXL4|T1FXL4_HELRO
Uncharacterized protein
Search

tr|T1FXL5|T1FXL5_HELRO
Uncharacterized protein
Search

CDK5R1

0.60	Cyclin-dependent kinase 5 activator

0.80	GO:0071902	positive regulation of protein serine/threonine kinase activity
0.54	GO:0021722	superior olivary nucleus maturation
0.54	GO:0042501	serine phosphorylation of STAT protein
0.54	GO:0030182	neuron differentiation
0.53	GO:0007158	neuron cell-cell adhesion
0.52	GO:0021819	layer formation in cerebral cortex
0.52	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.52	GO:0090314	positive regulation of protein targeting to membrane
0.52	GO:0000904	cell morphogenesis involved in differentiation
0.52	GO:0030517	negative regulation of axon extension

0.86	GO:0016534	cyclin-dependent protein kinase 5 activator activity
0.52	GO:0035255	ionotropic glutamate receptor binding
0.50	GO:0002020	protease binding
0.49	GO:0016301	kinase activity
0.48	GO:0019901	protein kinase binding
0.48	GO:0051015	actin filament binding
0.39	GO:0045296	cadherin binding
0.38	GO:0046875	ephrin receptor binding
0.37	GO:0005509	calcium ion binding
0.36	GO:0043014	alpha-tubulin binding

0.86	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex
0.48	GO:0048471	perinuclear region of cytoplasm
0.47	GO:0030426	growth cone
0.46	GO:0043025	neuronal cell body
0.46	GO:0030425	dendrite
0.45	GO:0030424	axon
0.45	GO:0005654	nucleoplasm
0.39	GO:0044309	neuron spine
0.39	GO:0031594	neuromuscular junction
0.39	GO:0014069	postsynaptic density

0.34

GO:0016773

tr|T1FXL6|T1FXL6_HELRO
Uncharacterized protein
Search

0.61	Cation Diffusion Facilitator (CDF) Family

0.61

GO:0098655

cation transmembrane transport

0.61

GO:0008324

cation transmembrane transporter activity

0.30

GO:0016021

integral component of membrane

tr|T1FXL7|T1FXL7_HELRO
Uncharacterized protein
Search

0.83	Mediator of RNA polymerase II transcription subunit 20

0.71	GO:0006357	regulation of transcription by RNA polymerase II
0.58	GO:0006351	transcription, DNA-templated
0.36	GO:0006629	lipid metabolic process
0.34	GO:0055114	oxidation-reduction process

0.79	GO:0001104	RNA polymerase II transcription cofactor activity
0.39	GO:0003713	transcription coactivator activity
0.37	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
0.36	GO:0005515	protein binding

0.77	GO:0016592	mediator complex
0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.37

EC:1.3

GO:0016627

tr|T1FXL8|T1FXL8_HELRO
Uncharacterized protein
Search

0.10	DEP domain-containing protein 5

0.58	GO:0035556	intracellular signal transduction
0.51	GO:0034198	cellular response to amino acid starvation
0.50	GO:0032007	negative regulation of TOR signaling
0.47	GO:1903432	regulation of TORC1 signaling
0.47	GO:0043547	positive regulation of GTPase activity
0.43	GO:0010506	regulation of autophagy
0.35	GO:2001141	regulation of RNA biosynthetic process
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0010468	regulation of gene expression
0.32	GO:0043043	peptide biosynthetic process

0.47	GO:0005096	GTPase activator activity
0.45	GO:0032403	protein complex binding
0.36	GO:0043565	sequence-specific DNA binding
0.33	GO:0004386	helicase activity
0.32	GO:0003735	structural constituent of ribosome

0.52	GO:1990130	GATOR1 complex
0.49	GO:0005765	lysosomal membrane
0.47	GO:0048471	perinuclear region of cytoplasm
0.43	GO:0005829	cytosol
0.35	GO:0005634	nucleus
0.32	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

tr|T1FXL9|T1FXL9_HELRO
Protein MAK16 homolog
Search

0.10	Putative rna-binding nuclear protein mak16 (Fragment)

0.47	GO:0000470	maturation of LSU-rRNA
0.46	GO:0000460	maturation of 5.8S rRNA

0.33

GO:0003723

RNA binding

0.69	GO:0005730	nucleolus
0.46	GO:0030687	preribosome, large subunit precursor
0.36	GO:0005840	ribosome

tr|T1FXM0|T1FXM0_HELRO
Uncharacterized protein
Search

0.53	GO:0072520	seminiferous tubule development
0.53	GO:0070197	meiotic attachment of telomere to nuclear envelope
0.52	GO:0007130	synaptonemal complex assembly
0.50	GO:0009566	fertilization
0.49	GO:0006302	double-strand break repair
0.49	GO:0007283	spermatogenesis
0.48	GO:0000725	recombinational repair
0.44	GO:0007062	sister chromatid cohesion
0.34	GO:0006333	chromatin assembly or disassembly

0.44	GO:0003682	chromatin binding
0.36	GO:0017075	syntaxin-1 binding

0.69	GO:0000228	nuclear chromosome
0.54	GO:0030893	meiotic cohesin complex
0.30	GO:0016020	membrane

tr|T1FXM1|T1FXM1_HELRO
Uncharacterized protein
Search

0.83	GO:0045035	sensory organ precursor cell division
0.82	GO:0061320	pericardial nephrocyte differentiation
0.82	GO:0061382	Malpighian tubule tip cell differentiation
0.82	GO:0042694	muscle cell fate specification
0.81	GO:0014019	neuroblast development
0.81	GO:0016360	sensory organ precursor cell fate determination
0.81	GO:0009786	regulation of asymmetric cell division
0.80	GO:0007406	negative regulation of neuroblast proliferation
0.79	GO:0055059	asymmetric neuroblast division
0.78	GO:0051642	centrosome localization

0.42	GO:0005112	Notch binding
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding

0.68	GO:0005938	cell cortex
0.42	GO:0045178	basal part of cell
0.37	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1FXM2|T1FXM2_HELRO
Uncharacterized protein
Search

0.55	T-box transcription factor TBX2

0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.48	GO:0046884	follicle-stimulating hormone secretion
0.47	GO:0032275	luteinizing hormone secretion
0.47	GO:0035050	embryonic heart tube development
0.46	GO:0030540	female genitalia development
0.46	GO:0045662	negative regulation of myoblast differentiation
0.46	GO:0035115	embryonic forelimb morphogenesis

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.43	GO:0001067	regulatory region nucleic acid binding
0.42	GO:0001102	RNA polymerase II activating transcription factor binding
0.34	GO:0051087	chaperone binding
0.34	GO:0031419	cobalamin binding

0.61	GO:0005634	nucleus
0.33	GO:0005667	transcription factor complex
0.30	GO:0016021	integral component of membrane

tr|T1FXM3|T1FXM3_HELRO
Uncharacterized protein
Search

0.11	Alpha-mannosidase 2x (Fragment)

0.81	GO:0006013	mannose metabolic process
0.52	GO:0006491	N-glycan processing
0.49	GO:0006517	protein deglycosylation
0.46	GO:0007585	respiratory gaseous exchange
0.46	GO:0048286	lung alveolus development
0.45	GO:0060042	retina morphogenesis in camera-type eye
0.45	GO:0001889	liver development
0.45	GO:0016063	rhodopsin biosynthetic process
0.45	GO:0001701	in utero embryonic development
0.44	GO:0035010	encapsulation of foreign target

0.79	GO:0004559	alpha-mannosidase activity
0.69	GO:0030246	carbohydrate binding
0.53	GO:0046872	metal ion binding
0.43	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds
0.34	GO:0005047	signal recognition particle binding
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0032561	guanyl ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.46	GO:0005797	Golgi medial cisterna
0.45	GO:0005801	cis-Golgi network
0.44	GO:0000139	Golgi membrane
0.42	GO:0005615	extracellular space
0.35	GO:1903561	extracellular vesicle
0.34	GO:0005785	signal recognition particle receptor complex
0.30	GO:0016021	integral component of membrane

0.79

EC:3.2.1.24

GO:0004559

tr|T1FXM4|T1FXM4_HELRO
Protein Wnt
Search

WNT1

0.86	Proto-oncogene Wnt-1

0.77	GO:0016055	Wnt signaling pathway
0.70	GO:0007275	multicellular organism development
0.55	GO:0045598	regulation of fat cell differentiation
0.55	GO:0030111	regulation of Wnt signaling pathway
0.52	GO:0048146	positive regulation of fibroblast proliferation
0.52	GO:0061184	positive regulation of dermatome development
0.52	GO:0036520	astrocyte-dopaminergic neuron signaling
0.52	GO:0009888	tissue development
0.52	GO:0030514	negative regulation of BMP signaling pathway
0.51	GO:0030154	cell differentiation

0.73	GO:0005102	receptor binding
0.48	GO:0030545	receptor regulator activity
0.48	GO:0044212	transcription regulatory region DNA binding
0.48	GO:0019904	protein domain specific binding
0.36	GO:0003700	DNA binding transcription factor activity
0.33	GO:0017147	Wnt-protein binding
0.33	GO:0005543	phospholipid binding

0.75	GO:0005578	proteinaceous extracellular matrix
0.51	GO:0009986	cell surface
0.45	GO:0005615	extracellular space
0.37	GO:0005737	cytoplasm
0.35	GO:0012505	endomembrane system
0.35	GO:0070013	intracellular organelle lumen
0.34	GO:1903561	extracellular vesicle
0.34	GO:1990909	Wnt signalosome
0.34	GO:0012506	vesicle membrane
0.34	GO:0044446	intracellular organelle part

tr|T1FXM5|T1FXM5_HELRO
Uncharacterized protein
Search

0.82	Large subunit ribosomal protein L19

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.52	GO:0009059	macromolecule biosynthetic process
0.34	GO:0022616	DNA strand elongation
0.32	GO:0016070	RNA metabolic process

0.64	GO:0003735	structural constituent of ribosome
0.34	GO:0043142	single-stranded DNA-dependent ATPase activity
0.34	GO:0017108	5'-flap endonuclease activity
0.33	GO:0008270	zinc ion binding

0.61	GO:0005840	ribosome
0.39	GO:0005759	mitochondrial matrix
0.35	GO:0031965	nuclear membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1FXM6|T1FXM6_HELRO
Uncharacterized protein
Search

0.35	GO:0007507	heart development
0.35	GO:0030036	actin cytoskeleton organization
0.33	GO:0006468	protein phosphorylation

0.54	GO:0046872	metal ion binding
0.35	GO:0003779	actin binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.35

GO:0030054

cell junction

tr|T1FXM7|T1FXM7_HELRO
Uncharacterized protein
Search

0.62	GO:0051301	cell division
0.53	GO:0031297	replication fork processing
0.51	GO:0071962	mitotic sister chromatid cohesion, centromeric
0.50	GO:1990758	mitotic sister chromatid biorientation
0.49	GO:0071459	protein localization to chromosome, centromeric region
0.48	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.45	GO:0006974	cellular response to DNA damage stimulus
0.37	GO:0010469	regulation of receptor activity
0.34	GO:0005975	carbohydrate metabolic process

0.49	GO:0051721	protein phosphatase 2A binding
0.48	GO:0004864	protein phosphatase inhibitor activity
0.38	GO:0005179	hormone activity
0.35	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.33	GO:0003677	DNA binding

0.49	GO:0000777	condensed chromosome kinetochore
0.47	GO:0005876	spindle microtubule
0.47	GO:0005815	microtubule organizing center
0.47	GO:0005654	nucleoplasm
0.47	GO:0000922	spindle pole
0.36	GO:0005576	extracellular region
0.35	GO:0005737	cytoplasm

0.35

GO:0004553

tr|T1FXM8|T1FXM8_HELRO
Uncharacterized protein
Search

tr|T1FXM9|T1FXM9_HELRO
Uncharacterized protein
Search

0.70	Allograft inflammatory factor-1

0.48	GO:0071673	positive regulation of smooth muscle cell chemotaxis
0.48	GO:0071672	negative regulation of smooth muscle cell chemotaxis
0.46	GO:0016601	Rac protein signal transduction
0.46	GO:2000406	positive regulation of T cell migration
0.46	GO:0090026	positive regulation of monocyte chemotaxis
0.46	GO:0097178	ruffle assembly
0.46	GO:0048662	negative regulation of smooth muscle cell proliferation
0.46	GO:0048661	positive regulation of smooth muscle cell proliferation
0.46	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
0.46	GO:0006911	phagocytosis, engulfment

0.70	GO:0005509	calcium ion binding
0.43	GO:0051015	actin filament binding

0.46	GO:0001891	phagocytic cup
0.45	GO:0032587	ruffle membrane
0.45	GO:0005884	actin filament
0.45	GO:0030027	lamellipodium
0.44	GO:0048471	perinuclear region of cytoplasm
0.41	GO:0005829	cytosol
0.39	GO:0005634	nucleus

tr|T1FXN0|T1FXN0_HELRO
Uncharacterized protein
Search

0.77	GO:0007339	binding of sperm to zona pellucida
0.44	GO:0003341	cilium movement
0.41	GO:0045859	regulation of protein kinase activity
0.34	GO:0016310	phosphorylation

0.46	GO:0005509	calcium ion binding
0.44	GO:0008603	cAMP-dependent protein kinase regulator activity
0.44	GO:0030552	cAMP binding
0.35	GO:0016301	kinase activity

0.44	GO:0005952	cAMP-dependent protein kinase complex
0.43	GO:0031514	motile cilium
0.39	GO:0005777	peroxisome
0.30	GO:0016020	membrane

tr|T1FXN1|T1FXN1_HELRO
Uncharacterized protein
Search

FXN

0.63	Iron donor protein CyaY

0.74	GO:0016226	iron-sulfur cluster assembly
0.55	GO:0018282	metal incorporation into metallo-sulfur cluster
0.54	GO:0010722	regulation of ferrochelatase activity
0.53	GO:1904231	positive regulation of succinate dehydrogenase activity
0.53	GO:1904234	positive regulation of aconitate hydratase activity
0.52	GO:0055114	oxidation-reduction process
0.51	GO:0090201	negative regulation of release of cytochrome c from mitochondria
0.51	GO:0010039	response to iron ion
0.50	GO:0006879	cellular iron ion homeostasis
0.50	GO:0070301	cellular response to hydrogen peroxide

0.80	GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor
0.76	GO:0008199	ferric iron binding
0.56	GO:0034986	iron chaperone activity
0.50	GO:0008198	ferrous iron binding
0.46	GO:0051537	2 iron, 2 sulfur cluster binding
0.36	GO:0042802	identical protein binding
0.36	GO:0016307	phosphatidylinositol phosphate kinase activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0008144	drug binding

0.60	GO:0005739	mitochondrion
0.44	GO:0005829	cytosol
0.36	GO:0043233	organelle lumen
0.35	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.80

EC:1.16.3

GO:0016724

tr|T1FXN2|T1FXN2_HELRO
Uncharacterized protein
Search

CSNK1G1

0.73	casein kinase I

0.62	GO:0006468	protein phosphorylation
0.44	GO:0018209	peptidyl-serine modification
0.40	GO:0016055	Wnt signaling pathway
0.39	GO:0006897	endocytosis
0.38	GO:0008360	regulation of cell shape
0.35	GO:0090217	negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
0.35	GO:0030590	first cell cycle pseudocleavage
0.35	GO:0032888	regulation of mitotic spindle elongation
0.34	GO:0008356	asymmetric cell division
0.34	GO:0051653	spindle localization

0.68	GO:0004674	protein serine/threonine kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0051219	phosphoprotein binding
0.34	GO:0042277	peptide binding
0.33	GO:0000287	magnesium ion binding

0.39	GO:0005829	cytosol
0.37	GO:0005634	nucleus
0.35	GO:0005818	aster
0.34	GO:0005938	cell cortex
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.68

GO:0004674

tr|T1FXN3|T1FXN3_HELRO
Uncharacterized protein
Search

0.69	GO:0006955	immune response
0.68	GO:0006898	receptor-mediated endocytosis
0.36	GO:0007229	integrin-mediated signaling pathway
0.36	GO:0007399	nervous system development
0.36	GO:0030154	cell differentiation
0.36	GO:0007186	G-protein coupled receptor signaling pathway
0.35	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.34	GO:0006508	proteolysis

0.76	GO:0005044	scavenger receptor activity
0.73	GO:0001871	pattern binding
0.66	GO:0030246	carbohydrate binding
0.36	GO:0004930	G-protein coupled receptor activity
0.35	GO:0004222	metalloendopeptidase activity
0.35	GO:0004521	endoribonuclease activity
0.35	GO:0003676	nucleic acid binding
0.33	GO:0046872	metal ion binding

0.35	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.35

GO:0004222

tr|T1FXN4|T1FXN4_HELRO
Uncharacterized protein
Search

0.86	GO:0007362	terminal region determination
0.85	GO:0048813	dendrite morphogenesis
0.81	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
0.71	GO:0045892	negative regulation of transcription, DNA-templated

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1FXN5|T1FXN5_HELRO
Glycogen [starch] synthase
Search

0.68	Glycogen [starch] synthase

0.76	GO:0005978	glycogen biosynthetic process
0.34	GO:0007264	small GTPase mediated signal transduction
0.33	GO:0065009	regulation of molecular function

0.80	GO:0004373	glycogen (starch) synthase activity
0.34	GO:0005085	guanyl-nucleotide exchange factor activity

0.31	GO:0005622	intracellular
0.30	GO:0031224	intrinsic component of membrane

0.80

EC:2.4.1.11

GO:0004373

tr|T1FXN6|T1FXN6_HELRO
Uncharacterized protein
Search

tr|T1FXN7|T1FXN7_HELRO
Uncharacterized protein
Search

0.44	Golgi resident protein GCP60 (Fragment)

0.82

GO:0000062

fatty-acyl-CoA binding

tr|T1FXN8|T1FXN8_HELRO
Uncharacterized protein
Search

tr|T1FXN9|T1FXN9_HELRO
Uncharacterized protein
Search

CCDC47

0.56	Coiled-coil domain-containing protein 47

0.42	GO:0006357	regulation of transcription by RNA polymerase II
0.37	GO:0006983	ER overload response
0.36	GO:0007029	endoplasmic reticulum organization
0.36	GO:0030433	ubiquitin-dependent ERAD pathway
0.36	GO:0055074	calcium ion homeostasis
0.36	GO:0009791	post-embryonic development
0.34	GO:0006468	protein phosphorylation

0.44	GO:0001104	RNA polymerase II transcription cofactor activity
0.42	GO:0005509	calcium ion binding
0.34	GO:0004672	protein kinase activity
0.34	GO:0003700	DNA binding transcription factor activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.44	GO:0016592	mediator complex
0.43	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane

tr|T1FXP0|T1FXP0_HELRO
Uncharacterized protein
Search

tr|T1FXP1|T1FXP1_HELRO
Uncharacterized protein
Search

DAAM1

0.88	Disheveled-associated activator of morphogenesis 1-A

0.73	GO:0030036	actin cytoskeleton organization
0.41	GO:0060026	convergent extension
0.36	GO:0030838	positive regulation of actin filament polymerization
0.36	GO:0097435	supramolecular fiber organization
0.35	GO:0021986	habenula development
0.35	GO:0048793	pronephros development
0.34	GO:0060071	Wnt signaling pathway, planar cell polarity pathway

0.77	GO:0017048	Rho GTPase binding
0.74	GO:0003779	actin binding
0.47	GO:0042802	identical protein binding
0.36	GO:0008017	microtubule binding

0.51	GO:0097517	contractile actin filament bundle
0.51	GO:0042641	actomyosin
0.50	GO:0036064	ciliary basal body
0.49	GO:0031514	motile cilium
0.45	GO:0005829	cytosol
0.40	GO:0005886	plasma membrane
0.37	GO:0005884	actin filament
0.30	GO:0031224	intrinsic component of membrane

tr|T1FXP2|T1FXP2_HELRO
Synaptotagmin 7e
Search

SYT7

0.85	Synaptotagmin VIIb

0.75	GO:0006887	exocytosis
0.54	GO:0099643	signal release from synapse
0.54	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.52	GO:0090119	vesicle-mediated cholesterol transport
0.52	GO:0017158	regulation of calcium ion-dependent exocytosis
0.52	GO:1990926	short-term synaptic potentiation
0.51	GO:0006836	neurotransmitter transport
0.51	GO:0070092	regulation of glucagon secretion
0.51	GO:0048489	synaptic vesicle transport
0.51	GO:0006906	vesicle fusion

0.81	GO:0005544	calcium-dependent phospholipid binding
0.51	GO:0000149	SNARE binding
0.49	GO:0001786	phosphatidylserine binding
0.48	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.46	GO:0005516	calmodulin binding
0.45	GO:0030276	clathrin binding
0.42	GO:0005509	calcium ion binding

0.53	GO:0098793	presynapse
0.50	GO:0032009	early phagosome
0.50	GO:0070382	exocytic vesicle
0.48	GO:0044306	neuron projection terminus
0.47	GO:0043025	neuronal cell body
0.47	GO:0030425	dendrite
0.46	GO:0097060	synaptic membrane
0.46	GO:0005764	lysosome
0.45	GO:0005777	peroxisome
0.43	GO:0005829	cytosol

tr|T1FXP3|T1FXP3_HELRO
Uncharacterized protein
Search

POFUT2

0.93	GDP-fucose protein O-fucosyltransferase 2

0.78	GO:0006004	fucose metabolic process
0.56	GO:0036066	protein O-linked fucosylation
0.49	GO:0001707	mesoderm formation
0.49	GO:0010717	regulation of epithelial to mesenchymal transition
0.48	GO:0051046	regulation of secretion
0.39	GO:0060255	regulation of macromolecule metabolic process
0.34	GO:0006869	lipid transport
0.33	GO:0006364	rRNA processing
0.32	GO:0055085	transmembrane transport
0.32	GO:0006508	proteolysis

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.42	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.46	GO:0005794	Golgi apparatus
0.36	GO:0005783	endoplasmic reticulum
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.33	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.65

GO:0016757

tr|T1FXP4|T1FXP4_HELRO
Uncharacterized protein
Search

tr|T1FXP5|T1FXP5_HELRO
Uncharacterized protein
Search

0.75	Potassium voltage-gated channel subfamily H member 2 (Fragment)

0.73	GO:0071805	potassium ion transmembrane transport
0.73	GO:0034765	regulation of ion transmembrane transport
0.53	GO:0023014	signal transduction by protein phosphorylation
0.51	GO:0000160	phosphorelay signal transduction system
0.45	GO:0071277	cellular response to calcium ion
0.44	GO:0042391	regulation of membrane potential
0.43	GO:0048015	phosphatidylinositol-mediated signaling
0.42	GO:0042127	regulation of cell proliferation
0.40	GO:0032501	multicellular organismal process
0.37	GO:0060322	head development

0.78	GO:0005249	voltage-gated potassium channel activity
0.54	GO:0000155	phosphorelay sensor kinase activity
0.44	GO:1902936	phosphatidylinositol bisphosphate binding
0.36	GO:0005516	calmodulin binding
0.36	GO:0071889	14-3-3 protein binding
0.35	GO:0044325	ion channel binding
0.35	GO:0030551	cyclic nucleotide binding
0.35	GO:0019901	protein kinase binding
0.34	GO:0046982	protein heterodimerization activity
0.34	GO:0042802	identical protein binding

0.53	GO:0005887	integral component of plasma membrane
0.44	GO:0031901	early endosome membrane
0.43	GO:0034705	potassium channel complex
0.37	GO:0042734	presynaptic membrane
0.37	GO:0043231	intracellular membrane-bounded organelle
0.36	GO:0043025	neuronal cell body
0.36	GO:0030425	dendrite
0.36	GO:0030424	axon
0.36	GO:0014069	postsynaptic density
0.36	GO:0045211	postsynaptic membrane

0.54

EC:2.7.3

GO:0000155

tr|T1FXP6|T1FXP6_HELRO
Uncharacterized protein
Search

PAPSS1

0.84	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase

0.76	GO:0000103	sulfate assimilation
0.57	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
0.57	GO:0016310	phosphorylation
0.36	GO:0001501	skeletal system development
0.34	GO:0007596	blood coagulation
0.34	GO:0006011	UDP-glucose metabolic process
0.34	GO:0048513	animal organ development

0.80	GO:0004020	adenylylsulfate kinase activity
0.79	GO:0004781	sulfate adenylyltransferase (ATP) activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0042803	protein homodimerization activity
0.36	GO:0098616	selenate adenylyltransferase (ATP) activity
0.34	GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity
0.33	GO:0008270	zinc ion binding

0.35	GO:0009336	sulfate adenylyltransferase complex (ATP)
0.34	GO:0005829	cytosol
0.33	GO:0005634	nucleus

0.80	EC:2.7.1.25	GO:0004020
0.34	KEGG:R00289	GO:0003983

tr|T1FXP7|T1FXP7_HELRO
Uncharacterized protein
Search

TM2D2

0.54	Beta-amyloid-binding protein-like protein 1

0.34

GO:0006506

GPI anchor biosynthetic process

0.34

GO:0017176

phosphatidylinositol N-acetylglucosaminyltransferase activity

0.30

GO:0031224

intrinsic component of membrane

0.34

EC:2.4.1.198

GO:0017176

tr|T1FXP8|T1FXP8_HELRO
Uncharacterized protein
Search

0.84	Glycosylphosphatidylinositol transamidase

0.45	GO:0006506	GPI anchor biosynthetic process
0.45	GO:0045313	rhabdomere membrane biogenesis
0.38	GO:0006508	proteolysis
0.34	GO:0016573	histone acetylation
0.33	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.33	GO:0006396	RNA processing
0.32	GO:0022900	electron transport chain
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.40	GO:0004252	serine-type endopeptidase activity
0.38	GO:0034235	GPI anchor binding
0.34	GO:0003923	GPI-anchor transamidase activity
0.34	GO:0004402	histone acetyltransferase activity
0.34	GO:0016727	oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor
0.34	GO:0004854	xanthine dehydrogenase activity
0.34	GO:0032296	double-stranded RNA-specific ribonuclease activity
0.33	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters
0.33	GO:0043546	molybdopterin cofactor binding
0.33	GO:0051537	2 iron, 2 sulfur cluster binding

0.81	GO:0042765	GPI-anchor transamidase complex
0.34	GO:0072487	MSL complex
0.33	GO:0031514	motile cilium
0.33	GO:0005887	integral component of plasma membrane

0.40

GO:0004252

tr|T1FXP9|T1FXP9_HELRO
Uncharacterized protein
Search

0.11	Enterin neuropeptide (Fragment)

0.46	GO:0007218	neuropeptide signaling pathway
0.42	GO:0007229	integrin-mediated signaling pathway
0.37	GO:0035023	regulation of Rho protein signal transduction
0.36	GO:0065009	regulation of molecular function
0.35	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.35	GO:0031047	gene silencing by RNA
0.35	GO:0050804	modulation of chemical synaptic transmission
0.35	GO:0045490	pectin catabolic process
0.35	GO:0050807	regulation of synapse organization
0.35	GO:0042127	regulation of cell proliferation

0.41	GO:0016630	protochlorophyllide reductase activity
0.38	GO:0019899	enzyme binding
0.36	GO:0098772	molecular function regulator
0.36	GO:0004523	RNA-DNA hybrid ribonuclease activity
0.35	GO:0030570	pectate lyase activity
0.35	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
0.35	GO:0003779	actin binding
0.34	GO:0003676	nucleic acid binding
0.34	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.34	GO:0003700	DNA binding transcription factor activity

0.35	GO:0005667	transcription factor complex
0.35	GO:0005764	lysosome
0.34	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.41

EC:1.3.1.33

GO:0016630

tr|T1FXQ0|T1FXQ0_HELRO
Uncharacterized protein
Search

0.56	ADP-ribosylation factor

0.38	GO:0032011	ARF protein signal transduction
0.38	GO:1904801	positive regulation of neuron remodeling
0.38	GO:1990386	mitotic cleavage furrow ingression
0.38	GO:0022412	cellular process involved in reproduction in multicellular organism
0.38	GO:0007276	gamete generation
0.37	GO:1902036	regulation of hematopoietic stem cell differentiation
0.37	GO:0033206	meiotic cytokinesis
0.37	GO:0010883	regulation of lipid storage
0.37	GO:0043001	Golgi to plasma membrane protein transport
0.37	GO:0001745	compound eye morphogenesis

0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0003924	GTPase activity
0.34	GO:0016004	phospholipase activator activity
0.33	GO:0005509	calcium ion binding
0.32	GO:0016301	kinase activity
0.32	GO:0022857	transmembrane transporter activity

0.45	GO:0005622	intracellular
0.37	GO:0097610	cell surface furrow
0.36	GO:0012505	endomembrane system
0.36	GO:0032155	cell division site part
0.36	GO:0045177	apical part of cell
0.35	GO:0043227	membrane-bounded organelle
0.33	GO:0044422	organelle part
0.33	GO:0098793	presynapse
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1FXQ1|T1FXQ1_HELRO
Uncharacterized protein
Search

0.50	GO:0006468	protein phosphorylation
0.47	GO:0045087	innate immune response
0.46	GO:0034158	toll-like receptor 8 signaling pathway
0.44	GO:0002755	MyD88-dependent toll-like receptor signaling pathway
0.43	GO:0050707	regulation of cytokine secretion
0.43	GO:0006954	inflammatory response
0.42	GO:0051607	defense response to virus
0.40	GO:0006171	cAMP biosynthetic process
0.37	GO:0007409	axonogenesis
0.36	GO:0046426	negative regulation of JAK-STAT cascade

0.50	GO:0004672	protein kinase activity
0.45	GO:0032559	adenyl ribonucleotide binding
0.44	GO:0008144	drug binding
0.44	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0003727	single-stranded RNA binding
0.42	GO:0003725	double-stranded RNA binding
0.40	GO:0004016	adenylate cyclase activity
0.36	GO:0003677	DNA binding
0.36	GO:0004721	phosphoprotein phosphatase activity
0.36	GO:0004860	protein kinase inhibitor activity

0.41	GO:0009505	plant-type cell wall
0.38	GO:0031225	anchored component of membrane
0.36	GO:0005578	proteinaceous extracellular matrix
0.36	GO:0005615	extracellular space
0.32	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.40

EC:4.6.1.1

GO:0004016

tr|T1FXQ2|T1FXQ2_HELRO
Uncharacterized protein
Search

GRINA

0.78	N methyl d aspartate selective glutamate receptor complex

0.38	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.38	GO:0032469	endoplasmic reticulum calcium ion homeostasis
0.35	GO:0006108	malate metabolic process
0.35	GO:0006099	tricarboxylic acid cycle
0.34	GO:1901215	negative regulation of neuron death
0.34	GO:0005975	carbohydrate metabolic process
0.33	GO:0055085	transmembrane transport

0.37	GO:0044325	ion channel binding
0.36	GO:0030060	L-malate dehydrogenase activity
0.33	GO:0022857	transmembrane transporter activity

0.36	GO:0005794	Golgi apparatus
0.36	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane

0.36

EC:1.1.1.37

GO:0030060

tr|T1FXQ3|T1FXQ3_HELRO
Uncharacterized protein
Search

0.43	GO:0061158	3'-UTR-mediated mRNA destabilization
0.37	GO:0097403	cellular response to raffinose
0.37	GO:1904582	positive regulation of intracellular mRNA localization
0.37	GO:0003343	septum transversum development
0.37	GO:1902172	regulation of keratinocyte apoptotic process
0.37	GO:0038066	p38MAPK cascade
0.37	GO:0045657	positive regulation of monocyte differentiation
0.37	GO:0048382	mesendoderm development
0.37	GO:0045647	negative regulation of erythrocyte differentiation
0.37	GO:1904628	cellular response to phorbol 13-acetate 12-myristate

0.54	GO:0046872	metal ion binding
0.41	GO:0003730	mRNA 3'-UTR binding
0.37	GO:0071889	14-3-3 protein binding
0.36	GO:0017091	AU-rich element binding
0.33	GO:0003924	GTPase activity
0.33	GO:0005525	GTP binding

0.37	GO:0005829	cytosol
0.36	GO:0000932	P-body
0.34	GO:0005634	nucleus

tr|T1FXQ4|T1FXQ4_HELRO
Uncharacterized protein
Search

0.65	Neuropeptide Y receptor invertebrate

0.80	GO:0007218	neuropeptide signaling pathway
0.34	GO:0006468	protein phosphorylation

0.84	GO:0004983	neuropeptide Y receptor activity
0.38	GO:0050254	rhodopsin kinase activity
0.35	GO:0042277	peptide binding
0.34	GO:0042562	hormone binding

0.30

GO:0044425

membrane part

0.38

GO:0050254

tr|T1FXQ5|T1FXQ5_HELRO
Uncharacterized protein
Search

TRA2A

0.72	transformer-2 protein homolog alpha

0.49	GO:0000398	mRNA splicing, via spliceosome
0.36	GO:0048026	positive regulation of mRNA splicing, via spliceosome
0.35	GO:0006413	translational initiation

0.59	GO:0003723	RNA binding
0.35	GO:0042802	identical protein binding

0.48	GO:0005730	nucleolus
0.33	GO:0005615	extracellular space

tr|T1FXQ6|T1FXQ6_HELRO
Uncharacterized protein
Search

0.70	GO:0007475	apposition of dorsal and ventral imaginal disc-derived wing surfaces
0.70	GO:0043508	negative regulation of JUN kinase activity
0.63	GO:0007229	integrin-mediated signaling pathway
0.53	GO:0006468	protein phosphorylation

0.54	GO:0004672	protein kinase activity
0.47	GO:0032559	adenyl ribonucleotide binding
0.47	GO:0008144	drug binding
0.47	GO:0035639	purine ribonucleoside triphosphate binding

0.30

GO:0016020

membrane

tr|T1FXQ7|T1FXQ7_HELRO
Uncharacterized protein
Search

0.30	angio-associated migratory cell protein-like

tr|T1FXQ8|T1FXQ8_HELRO
Uncharacterized protein
Search

HIRA

0.92	Histone cell cycle regulator

0.72	GO:0006325	chromatin organization
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:0043412	macromolecule modification
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.51	GO:0065004	protein-DNA complex assembly
0.50	GO:0006323	DNA packaging
0.47	GO:0001649	osteoblast differentiation
0.47	GO:1902275	regulation of chromatin organization

0.47	GO:0031491	nucleosome binding
0.47	GO:0003714	transcription corepressor activity
0.35	GO:0005515	protein binding
0.33	GO:0003700	DNA binding transcription factor activity

0.61	GO:0005634	nucleus
0.49	GO:0000785	chromatin
0.47	GO:0031974	membrane-enclosed lumen
0.41	GO:0043234	protein complex
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

tr|T1FXQ9|T1FXQ9_HELRO
Uncharacterized protein
Search

0.50	GO:0021972	corticospinal neuron axon guidance through spinal cord
0.50	GO:0090260	negative regulation of retinal ganglion cell axon guidance
0.50	GO:0050929	induction of negative chemotaxis
0.50	GO:0021836	chemorepulsion involved in postnatal olfactory bulb interneuron migration
0.50	GO:0010593	negative regulation of lamellipodium assembly
0.50	GO:0090024	negative regulation of neutrophil chemotaxis
0.49	GO:0071672	negative regulation of smooth muscle cell chemotaxis
0.49	GO:0071504	cellular response to heparin
0.49	GO:0071676	negative regulation of mononuclear cell migration
0.49	GO:0031290	retinal ganglion cell axon guidance

0.69	GO:0005509	calcium ion binding
0.50	GO:0043237	laminin-1 binding
0.49	GO:0048495	Roundabout binding
0.49	GO:0005095	GTPase inhibitor activity
0.48	GO:0043394	proteoglycan binding
0.46	GO:0008201	heparin binding
0.44	GO:0042803	protein homodimerization activity
0.40	GO:0004252	serine-type endopeptidase activity
0.39	GO:0004872	receptor activity
0.37	GO:0005201	extracellular matrix structural constituent

0.55	GO:0005576	extracellular region
0.36	GO:0005737	cytoplasm
0.35	GO:0031982	vesicle
0.35	GO:0005886	plasma membrane
0.35	GO:0009986	cell surface
0.34	GO:0030054	cell junction
0.33	GO:0045178	basal part of cell
0.33	GO:0031594	neuromuscular junction
0.33	GO:0005634	nucleus
0.33	GO:0032991	macromolecular complex

0.40

GO:0004252

tr|T1FXR0|T1FXR0_HELRO
Uncharacterized protein
Search

ABHD2

0.73	abhydrolase domain-containing protein 2-A

0.57	GO:0046464	acylglycerol catabolic process
0.57	GO:0048240	sperm capacitation
0.55	GO:0032570	response to progesterone
0.54	GO:0007340	acrosome reaction
0.53	GO:0043401	steroid hormone mediated signaling pathway
0.52	GO:0030336	negative regulation of cell migration
0.50	GO:0009611	response to wounding
0.32	GO:0016310	phosphorylation

0.57	GO:0047372	acylglycerol lipase activity
0.53	GO:0042562	hormone binding
0.51	GO:0003707	steroid hormone receptor activity
0.33	GO:0008270	zinc ion binding
0.32	GO:0003677	DNA binding
0.32	GO:0016301	kinase activity

0.58	GO:0097524	sperm plasma membrane
0.55	GO:0036126	sperm flagellum
0.53	GO:0001669	acrosomal vesicle
0.35	GO:0030667	secretory granule membrane
0.30	GO:0016021	integral component of membrane

0.57

EC:3.1.1.23

GO:0047372

tr|T1FXR1|T1FXR1_HELRO
Uncharacterized protein
Search

DESI1

0.25	Desumoylating isopeptidase 1

0.59	GO:0045454	cell redox homeostasis
0.35	GO:0006508	proteolysis

0.42	GO:0033925	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
0.38	GO:0005515	protein binding
0.35	GO:0008233	peptidase activity

0.37	GO:0005634	nucleus
0.35	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.42

EC:3.2.1.96

GO:0033925

tr|T1FXR2|T1FXR2_HELRO
Uncharacterized protein
Search

tr|T1FXR3|T1FXR3_HELRO
Uncharacterized protein
Search

0.49	Serine/threonine-protein kinase mig-15

0.63	GO:0006468	protein phosphorylation
0.49	GO:0000185	activation of MAPKKK activity
0.42	GO:0031098	stress-activated protein kinase signaling cascade
0.41	GO:0048812	neuron projection morphogenesis
0.41	GO:0001748	optic lobe placode development
0.40	GO:0046529	imaginal disc fusion, thorax closure
0.40	GO:0045995	regulation of embryonic development
0.40	GO:0008594	photoreceptor cell morphogenesis
0.40	GO:0005975	carbohydrate metabolic process
0.40	GO:0007391	dorsal closure

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0005057	signal transducer activity, downstream of receptor
0.42	GO:0030246	carbohydrate binding
0.42	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds

0.38	GO:0005938	cell cortex
0.36	GO:0070938	contractile ring
0.30	GO:0016020	membrane

0.42

GO:0004553

tr|T1FXR4|T1FXR4_HELRO
Uncharacterized protein
Search

CSTF3

0.93	Cleavage stimulation factor subunit 3

0.70	GO:0006397	mRNA processing
0.45	GO:0006379	mRNA cleavage
0.44	GO:0031123	RNA 3'-end processing
0.34	GO:0006369	termination of RNA polymerase II transcription
0.34	GO:0043631	RNA polyadenylation
0.34	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

0.43	GO:0003729	mRNA binding
0.34	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.45	GO:0031974	membrane-enclosed lumen
0.41	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

tr|T1FXR5|T1FXR5_HELRO
Uncharacterized protein
Search

0.69	heart- and neural crest derivatives-expressed protein 2

0.63	GO:0003219	cardiac right ventricle formation
0.61	GO:0060536	cartilage morphogenesis
0.60	GO:2000677	regulation of transcription regulatory region DNA binding
0.59	GO:0043392	negative regulation of DNA binding
0.59	GO:0001947	heart looping
0.58	GO:0043433	negative regulation of DNA binding transcription factor activity
0.58	GO:0042475	odontogenesis of dentin-containing tooth
0.57	GO:0060485	mesenchyme development
0.56	GO:0048514	blood vessel morphogenesis
0.55	GO:0001701	in utero embryonic development

0.68	GO:0046983	protein dimerization activity
0.57	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.57	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.52	GO:0042802	identical protein binding
0.52	GO:0008134	transcription factor binding
0.52	GO:0003680	AT DNA binding
0.50	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.50	GO:0003713	transcription coactivator activity
0.49	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.45	GO:0019899	enzyme binding

0.53	GO:0005667	transcription factor complex
0.50	GO:0031981	nuclear lumen
0.46	GO:0000785	chromatin
0.37	GO:0005737	cytoplasm

tr|T1FXR6|T1FXR6_HELRO
Uncharacterized protein
Search

0.81	Transcriptional repressor protein YY1

0.42	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II
0.42	GO:0032688	negative regulation of interferon-beta production
0.42	GO:0010225	response to UV-C
0.41	GO:0034644	cellular response to UV
0.41	GO:0048593	camera-type eye morphogenesis
0.40	GO:0010628	positive regulation of gene expression
0.40	GO:0009952	anterior/posterior pattern specification
0.40	GO:0007283	spermatogenesis
0.39	GO:0000724	double-strand break repair via homologous recombination
0.39	GO:0006403	RNA localization

0.51	GO:0003676	nucleic acid binding
0.41	GO:0046332	SMAD binding
0.41	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.33	GO:0004222	metalloendopeptidase activity

0.40	GO:0031519	PcG protein complex
0.40	GO:0031011	Ino80 complex
0.39	GO:0005667	transcription factor complex
0.30	GO:0016020	membrane

0.35

GO:0036459

tr|T1FXR7|T1FXR7_HELRO
Uncharacterized protein
Search

0.63	heterogeneous nuclear ribonucleoprotein U-like protein 1

0.58	GO:0009615	response to virus
0.50	GO:0006396	RNA processing

0.65	GO:0019013	viral nucleocapsid
0.56	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1FXR8|T1FXR8_HELRO
Uncharacterized protein
Search

0.93	Dopamine beta-hydroxylase

0.53	GO:0055114	oxidation-reduction process
0.47	GO:0048149	behavioral response to ethanol
0.47	GO:0042420	dopamine catabolic process
0.47	GO:0042421	norepinephrine biosynthetic process
0.46	GO:0019098	reproductive behavior
0.46	GO:0007613	memory
0.46	GO:0007612	learning
0.46	GO:0006589	octopamine biosynthetic process
0.45	GO:0007626	locomotory behavior
0.45	GO:0071927	octopamine signaling pathway

0.84	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
0.72	GO:0005507	copper ion binding
0.36	GO:0031418	L-ascorbic acid binding
0.33	GO:0008173	RNA methyltransferase activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0003676	nucleic acid binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0030667	secretory granule membrane
0.43	GO:0034774	secretory granule lumen
0.42	GO:0005615	extracellular space
0.39	GO:0005815	microtubule organizing center
0.38	GO:0005783	endoplasmic reticulum
0.38	GO:0042583	chromaffin granule
0.36	GO:0030658	transport vesicle membrane
0.30	GO:0031224	intrinsic component of membrane

0.84

EC:1.14.17

GO:0016715

tr|T1FXR9|T1FXR9_HELRO
60S ribosomal protein L29
Search

RPL-29

0.70	60S ribosomal protein L29

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process

0.64	GO:0003735	structural constituent of ribosome
0.36	GO:0045296	cadherin binding

0.61	GO:0005840	ribosome
0.40	GO:0044445	cytosolic part
0.37	GO:0044446	intracellular organelle part

tr|T1FXS0|T1FXS0_HELRO
Uncharacterized protein
Search

0.11	TRAF3-interacting protein 1 (Fragment)

0.45	GO:0042073	intraciliary transport
0.45	GO:0060271	cilium assembly
0.39	GO:0032480	negative regulation of type I interferon production
0.39	GO:0050687	negative regulation of defense response to virus
0.39	GO:0001822	kidney development
0.39	GO:0070507	regulation of microtubule cytoskeleton organization
0.39	GO:0001738	morphogenesis of a polarized epithelium
0.39	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
0.38	GO:0043010	camera-type eye development
0.38	GO:0036342	post-anal tail morphogenesis

0.74	GO:0008017	microtubule binding
0.34	GO:0005215	transporter activity
0.32	GO:0016301	kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.47	GO:0030992	intraciliary transport particle B
0.44	GO:0005929	cilium
0.44	GO:0005815	microtubule organizing center
0.39	GO:0032838	plasma membrane bounded cell projection cytoplasm

tr|T1FXS1|T1FXS1_HELRO
Uncharacterized protein
Search

D2HGDH

0.44	D-lactate dehydrogenase

0.53	GO:0055114	oxidation-reduction process
0.46	GO:0006089	lactate metabolic process
0.39	GO:1901616	organic hydroxy compound catabolic process
0.39	GO:0072329	monocarboxylic acid catabolic process
0.38	GO:0006091	generation of precursor metabolites and energy
0.37	GO:0009853	photorespiration
0.35	GO:0032025	response to cobalt ion
0.35	GO:0010042	response to manganese ion
0.34	GO:0032026	response to magnesium ion
0.34	GO:0010043	response to zinc ion

0.66	GO:0050660	flavin adenine dinucleotide binding
0.65	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
0.39	GO:0003779	actin binding
0.34	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.33	GO:0030983	mismatched DNA binding
0.33	GO:0008270	zinc ion binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032553	ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.41	GO:0005739	mitochondrion
0.38	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.65

EC:1.1

GO:0016614

tr|T1FXS2|T1FXS2_HELRO
Uncharacterized protein
Search

DDX52

0.53	ATP-dependent RNA helicase

0.47	GO:0010501	RNA secondary structure unwinding
0.43	GO:0006364	rRNA processing
0.35	GO:0001731	formation of translation preinitiation complex
0.33	GO:0045893	positive regulation of transcription, DNA-templated
0.33	GO:0008299	isoprenoid biosynthetic process
0.33	GO:0006511	ubiquitin-dependent protein catabolic process

0.60	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.45	GO:0008186	RNA-dependent ATPase activity
0.40	GO:0140098	catalytic activity, acting on RNA
0.34	GO:0004421	hydroxymethylglutaryl-CoA synthase activity
0.34	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
0.34	GO:0004843	thiol-dependent ubiquitin-specific protease activity

0.44	GO:0005730	nucleolus
0.37	GO:0005737	cytoplasm
0.34	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0005654	nucleoplasm
0.33	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

0.34	EC:2.3.3.10	GO:0004421
0.34	KEGG:R01978	GO:0004421

tr|T1FXS3|T1FXS3_HELRO
Uncharacterized protein
Search

CARNMT1

0.76	Carnosine N-methyltransferase

0.69	GO:0035498	carnosine metabolic process
0.61	GO:0032259	methylation
0.39	GO:0008213	protein alkylation

0.72

GO:0030735

carnosine N-methyltransferase activity

0.53	GO:0005829	cytosol
0.49	GO:0005634	nucleus
0.39	GO:0030014	CCR4-NOT complex
0.30	GO:0031224	intrinsic component of membrane

0.72	EC:2.1.1.22	GO:0030735
0.72	KEGG:R02144	GO:0030735

tr|T1FXS4|T1FXS4_HELRO
Uncharacterized protein
Search

TMEM229B

0.64	Transmembrane domain-containing protein (Fragment)

0.30

GO:0044425

membrane part

tr|T1FXS5|T1FXS5_HELRO
Uncharacterized protein
Search

ISL2

0.92	Insulin protein enhancer protein ISL-2

0.59	GO:0021524	visceral motor neuron differentiation
0.57	GO:0021520	spinal cord motor neuron cell fate specification
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0031290	retinal ganglion cell axon guidance
0.56	GO:0010468	regulation of gene expression
0.54	GO:0045665	negative regulation of neuron differentiation
0.43	GO:0048934	peripheral nervous system neuron differentiation
0.42	GO:0071657	positive regulation of granulocyte colony-stimulating factor production
0.42	GO:0060913	cardiac cell fate determination

0.64	GO:0043565	sequence-specific DNA binding
0.53	GO:0046872	metal ion binding
0.44	GO:0042578	phosphoric ester hydrolase activity
0.41	GO:0043425	bHLH transcription factor binding
0.41	GO:1990841	promoter-specific chromatin binding
0.40	GO:0001105	RNA polymerase II transcription coactivator activity
0.40	GO:0001102	RNA polymerase II activating transcription factor binding
0.40	GO:0035326	enhancer binding
0.38	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.38	GO:0070013	intracellular organelle lumen
0.36	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.44

EC:3.1

GO:0042578

tr|T1FXS6|T1FXS6_HELRO
Uncharacterized protein
Search

NAA60

0.69	N-alpha-acetyltransferase

0.56	GO:0017196	N-terminal peptidyl-methionine acetylation
0.51	GO:0043967	histone H4 acetylation
0.51	GO:0006334	nucleosome assembly
0.49	GO:0008283	cell proliferation
0.43	GO:0007059	chromosome segregation

0.68	GO:0008080	N-acetyltransferase activity
0.48	GO:0042803	protein homodimerization activity
0.32	GO:0003676	nucleic acid binding

0.47	GO:0000139	Golgi membrane
0.30	GO:0031224	intrinsic component of membrane

0.68

GO:0008080

tr|T1FXS7|T1FXS7_HELRO
Uncharacterized protein
Search

EIF4E2

0.94	Eukaryotic translation initiation factor 4E member 2

0.72	GO:0006413	translational initiation
0.49	GO:0001701	in utero embryonic development
0.47	GO:0017148	negative regulation of translation
0.34	GO:0055114	oxidation-reduction process

0.73	GO:0003743	translation initiation factor activity
0.48	GO:0031625	ubiquitin protein ligase binding
0.37	GO:0005509	calcium ion binding
0.36	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.35	GO:0020037	heme binding
0.35	GO:0005506	iron ion binding
0.34	GO:0000339	RNA cap binding

0.51	GO:0005845	mRNA cap binding complex
0.49	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.36

GO:0016705

tr|T1FXS8|T1FXS8_HELRO
Uncharacterized protein
Search

PITPNB

0.76	Phosphatidylinositol transfer protein alpha

0.79	GO:0015914	phospholipid transport
0.37	GO:0016579	protein deubiquitination
0.36	GO:0035845	photoreceptor cell outer segment organization
0.36	GO:0006511	ubiquitin-dependent protein catabolic process
0.35	GO:0001701	in utero embryonic development
0.34	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.34	GO:0006997	nucleus organization
0.33	GO:0006629	lipid metabolic process

0.80	GO:0005548	phospholipid transporter activity
0.48	GO:0031210	phosphatidylcholine binding
0.44	GO:0035091	phosphatidylinositol binding
0.37	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.33	GO:0016740	transferase activity

0.45	GO:0005622	intracellular
0.37	GO:0012505	endomembrane system
0.35	GO:0070062	extracellular exosome
0.34	GO:0044422	organelle part
0.30	GO:0031224	intrinsic component of membrane

0.37

GO:0036459

tr|T1FXS9|T1FXS9_HELRO
Uncharacterized protein
Search

0.72	GO:0051013	microtubule severing
0.49	GO:0051301	cell division
0.49	GO:0007049	cell cycle
0.38	GO:0042254	ribosome biogenesis
0.37	GO:0030010	establishment of cell polarity
0.37	GO:0016072	rRNA metabolic process
0.36	GO:0051656	establishment of organelle localization
0.36	GO:0034470	ncRNA processing
0.36	GO:0007165	signal transduction
0.35	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

0.64	GO:0008017	microtubule binding
0.39	GO:0003676	nucleic acid binding
0.37	GO:0070840	dynein complex binding
0.36	GO:0004534	5'-3' exoribonuclease activity
0.35	GO:0016301	kinase activity
0.35	GO:0051015	actin filament binding
0.33	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.33	GO:0140096	catalytic activity, acting on a protein

0.75	GO:0008352	katanin complex
0.64	GO:0005874	microtubule
0.54	GO:0000922	spindle pole
0.53	GO:0005813	centrosome
0.41	GO:0005634	nucleus
0.40	GO:0120114	Sm-like protein family complex
0.39	GO:0032040	small-subunit processome
0.37	GO:0043233	organelle lumen
0.36	GO:0042643	actomyosin, actin portion
0.35	GO:0031931	TORC1 complex

0.36

EC:3.1.13

GO:0004534

tr|T1FXT0|T1FXT0_HELRO
Uncharacterized protein
Search

0.56	Inactive ubiquitin carboxyl-terminal hydrolase 54

0.73

GO:0016579

protein deubiquitination

0.73

GO:0036459

thiol-dependent ubiquitinyl hydrolase activity

0.73

GO:0036459

tr|T1FXT1|T1FXT1_HELRO
Uncharacterized protein
Search

0.65	GO:0043547	positive regulation of GTPase activity
0.61	GO:0007165	signal transduction
0.40	GO:0006468	protein phosphorylation
0.33	GO:0007018	microtubule-based movement

0.65	GO:0005096	GTPase activator activity
0.53	GO:0005543	phospholipid binding
0.40	GO:0004672	protein kinase activity
0.38	GO:0032559	adenyl ribonucleotide binding
0.37	GO:0008144	drug binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003777	microtubule motor activity
0.33	GO:0008017	microtubule binding
0.33	GO:0003779	actin binding
0.32	GO:0046872	metal ion binding

0.33	GO:0016459	myosin complex
0.30	GO:0016020	membrane

tr|T1FXT2|T1FXT2_HELRO
Uncharacterized protein
Search

0.69	serine/threonine-protein kinase 3

0.63	GO:0006468	protein phosphorylation
0.59	GO:0007165	signal transduction
0.45	GO:0060800	regulation of cell differentiation involved in embryonic placenta development
0.45	GO:0097284	hepatocyte apoptotic process
0.45	GO:0001934	positive regulation of protein phosphorylation
0.44	GO:0003157	endocardium development
0.44	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
0.44	GO:0060215	primitive hemopoiesis
0.44	GO:0046621	negative regulation of organ growth
0.44	GO:0032092	positive regulation of protein binding

0.68	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0042802	identical protein binding
0.39	GO:0000287	magnesium ion binding
0.34	GO:0043539	protein serine/threonine kinase activator activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0046983	protein dimerization activity

0.38	GO:0043234	protein complex
0.36	GO:0005737	cytoplasm
0.33	GO:0005921	gap junction
0.33	GO:0005634	nucleus
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.68

GO:0004674

tr|T1FXT3|T1FXT3_HELRO
Uncharacterized protein
Search

CDKL2

0.74	Cyclin dependent kinase like 2

0.63	GO:0006468	protein phosphorylation
0.45	GO:0051726	regulation of cell cycle
0.42	GO:0000281	mitotic cytokinesis
0.38	GO:1903955	positive regulation of protein targeting to mitochondrion
0.34	GO:0007548	sex differentiation
0.33	GO:0071897	DNA biosynthetic process
0.33	GO:0006260	DNA replication
0.33	GO:0007165	signal transduction
0.33	GO:0043043	peptide biosynthetic process
0.32	GO:0010467	gene expression

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0060089	molecular transducer activity
0.33	GO:0003887	DNA-directed DNA polymerase activity
0.33	GO:0003735	structural constituent of ribosome
0.33	GO:0003677	DNA binding
0.32	GO:0022857	transmembrane transporter activity

0.49	GO:0005813	centrosome
0.45	GO:0005634	nucleus
0.35	GO:0005737	cytoplasm
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:2.7.7.7

GO:0003887

tr|T1FXT4|T1FXT4_HELRO
Uncharacterized protein
Search

0.61	Putative DNAJ domain-containing protein Caj1/Djp1 type

0.37	GO:0009408	response to heat
0.37	GO:0006457	protein folding
0.36	GO:0006260	DNA replication
0.35	GO:0006397	mRNA processing
0.33	GO:0000055	ribosomal large subunit export from nucleus
0.33	GO:0032781	positive regulation of ATPase activity
0.33	GO:0042273	ribosomal large subunit biogenesis
0.32	GO:0006897	endocytosis
0.32	GO:0006364	rRNA processing
0.32	GO:0031204	posttranslational protein targeting to membrane, translocation

0.60	GO:0008270	zinc ion binding
0.50	GO:0003676	nucleic acid binding
0.38	GO:0051082	unfolded protein binding
0.38	GO:0031072	heat shock protein binding
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0001671	ATPase activator activity

0.34	GO:0005634	nucleus
0.33	GO:0005737	cytoplasm
0.32	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.32	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.30	GO:0016021	integral component of membrane

tr|T1FXT5|T1FXT5_HELRO
Uncharacterized protein
Search

tr|T1FXT6|T1FXT6_HELRO
Uncharacterized protein
Search

0.49	GTPase-activating protein ZNF289

0.76	GO:0043547	positive regulation of GTPase activity
0.36	GO:0042157	lipoprotein metabolic process
0.36	GO:0006869	lipid transport
0.35	GO:0009737	response to abscisic acid

0.76	GO:0005096	GTPase activator activity
0.52	GO:0046872	metal ion binding
0.35	GO:0008289	lipid binding

0.35	GO:0005576	extracellular region
0.33	GO:0005829	cytosol
0.30	GO:0044425	membrane part

tr|T1FXT7|T1FXT7_HELRO
Uncharacterized protein
Search

tr|T1FXT8|T1FXT8_HELRO
Uncharacterized protein
Search

0.66	Epidermal growth factor receptor pathway substrate 15 like 1

0.35	GO:0006897	endocytosis
0.35	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
0.33	GO:0006457	protein folding
0.33	GO:0061024	membrane organization

0.68	GO:0005509	calcium ion binding
0.49	GO:0045296	cadherin binding
0.34	GO:0051082	unfolded protein binding

0.49	GO:0030132	clathrin coat of coated pit
0.34	GO:0005634	nucleus
0.34	GO:0005783	endoplasmic reticulum
0.33	GO:0005829	cytosol

tr|T1FXT9|T1FXT9_HELRO
Uncharacterized protein
Search

0.38	Phospholipase A2

0.82	GO:1903963	arachidonate transport
0.82	GO:0032309	icosanoid secretion
0.67	GO:0006644	phospholipid metabolic process
0.45	GO:0016042	lipid catabolic process

0.82	GO:0004623	phospholipase A2 activity
0.49	GO:0102568	phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
0.49	GO:0102567	phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
0.38	GO:0046872	metal ion binding

0.65

GO:0005576

extracellular region

0.82

EC:3.1.1.4

GO:0004623

tr|T1FXU0|T1FXU0_HELRO
Uncharacterized protein
Search

0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:0010468	regulation of gene expression
0.42	GO:0030154	cell differentiation

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.44	GO:0044212	transcription regulatory region DNA binding

0.61	GO:0005634	nucleus
0.30	GO:0044425	membrane part

tr|T1FXU1|T1FXU1_HELRO
Uncharacterized protein
Search

ZNRF1

0.59	Zinc and ring finger 1

0.59	GO:0070936	protein K48-linked ubiquitination
0.56	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.36	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.35	GO:0007010	cytoskeleton organization
0.33	GO:0006355	regulation of transcription, DNA-templated
0.33	GO:0055114	oxidation-reduction process

0.56	GO:0016874	ligase activity
0.56	GO:0061630	ubiquitin protein ligase activity
0.37	GO:0046872	metal ion binding
0.35	GO:0004499	N,N-dimethylaniline monooxygenase activity
0.35	GO:0005515	protein binding
0.32	GO:0003676	nucleic acid binding

0.53	GO:0005768	endosome
0.49	GO:0005829	cytosol
0.42	GO:0005764	lysosome
0.41	GO:0030659	cytoplasmic vesicle membrane
0.39	GO:0008021	synaptic vesicle
0.38	GO:0030054	cell junction
0.38	GO:0098805	whole membrane
0.37	GO:0098588	bounding membrane of organelle
0.35	GO:0043234	protein complex
0.34	GO:0005886	plasma membrane

0.56

GO:0016874

tr|T1FXU2|T1FXU2_HELRO
Uncharacterized protein
Search

MHC

0.49	Myosin and Myosin head domain containing protein

0.74	GO:0007018	microtubule-based movement
0.39	GO:0060279	positive regulation of ovulation
0.38	GO:0007626	locomotory behavior
0.33	GO:0007155	cell adhesion

0.76	GO:0051015	actin filament binding
0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005516	calmodulin binding

0.77	GO:0016459	myosin complex
0.38	GO:0030016	myofibril
0.37	GO:0044449	contractile fiber part

tr|T1FXU3|T1FXU3_HELRO
Serine/threonine-protein kinase PLK
Search

PLK1

0.58	Serine/threonine-protein kinase polo

0.63	GO:0006468	protein phosphorylation
0.53	GO:0007098	centrosome cycle
0.49	GO:0051081	nuclear envelope disassembly
0.48	GO:0090435	protein localization to nuclear envelope
0.48	GO:0072425	signal transduction involved in G2 DNA damage checkpoint
0.48	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
0.48	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
0.48	GO:1901673	regulation of mitotic spindle assembly
0.48	GO:0071168	protein localization to chromatin
0.48	GO:0070194	synaptonemal complex disassembly

0.64	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.46	GO:0010997	anaphase-promoting complex binding
0.45	GO:0019901	protein kinase binding
0.44	GO:0042802	identical protein binding
0.44	GO:0008017	microtubule binding
0.41	GO:0000287	magnesium ion binding

0.50	GO:0005815	microtubule organizing center
0.47	GO:0051233	spindle midzone
0.46	GO:0030496	midbody
0.46	GO:0005876	spindle microtubule
0.46	GO:0000942	condensed nuclear chromosome outer kinetochore
0.46	GO:0000795	synaptonemal complex
0.45	GO:0000922	spindle pole
0.42	GO:0000785	chromatin
0.38	GO:0044444	cytoplasmic part
0.33	GO:0005654	nucleoplasm

0.64	EC:2.7.11	GO:0004674
0.33	KEGG:R03876	GO:0004842

tr|T1FXU4|T1FXU4_HELRO
Uncharacterized protein
Search

tr|T1FXU5|T1FXU5_HELRO
Uncharacterized protein
Search

PSMC3IP

0.92	homologous-pairing protein 2 homolog

0.82	GO:0007131	reciprocal meiotic recombination
0.42	GO:2001141	regulation of RNA biosynthetic process
0.34	GO:0007129	synapsis
0.34	GO:0051254	positive regulation of RNA metabolic process
0.34	GO:0010557	positive regulation of macromolecule biosynthetic process
0.34	GO:0031328	positive regulation of cellular biosynthetic process
0.34	GO:0010628	positive regulation of gene expression
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0007093	mitotic cell cycle checkpoint
0.32	GO:0051304	chromosome separation

0.55	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
0.35	GO:0050692	DBD domain binding
0.35	GO:0035259	glucocorticoid receptor binding
0.35	GO:0046966	thyroid hormone receptor binding
0.35	GO:0050681	androgen receptor binding
0.35	GO:0030331	estrogen receptor binding
0.34	GO:0042803	protein homodimerization activity
0.34	GO:0003677	DNA binding
0.32	GO:0004712	protein serine/threonine/tyrosine kinase activity
0.31	GO:0005524	ATP binding

0.48	GO:0005654	nucleoplasm
0.40	GO:1905369	endopeptidase complex
0.37	GO:0043234	protein complex
0.35	GO:0071686	horsetail nucleus
0.33	GO:0000790	nuclear chromatin
0.30	GO:0016020	membrane

0.32

EC:2.7.12.1

GO:0004712

tr|T1FXU6|T1FXU6_HELRO
Uncharacterized protein
Search

SH3GLB1

0.87	SH3 domain containing GRB2 like, endophilin B1

0.47	GO:1903778	protein localization to vacuolar membrane
0.47	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
0.46	GO:0048102	autophagic cell death
0.46	GO:2000786	positive regulation of autophagosome assembly
0.46	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
0.45	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
0.45	GO:1903749	positive regulation of establishment of protein localization to mitochondrion
0.44	GO:0051084	'de novo' posttranslational protein folding
0.44	GO:0006654	phosphatidic acid biosynthetic process
0.42	GO:1905477	positive regulation of protein localization to membrane

0.45	GO:0005504	fatty acid binding
0.43	GO:0042171	lysophosphatidic acid acyltransferase activity
0.37	GO:0045296	cadherin binding
0.36	GO:0042803	protein homodimerization activity
0.35	GO:0061778	intracellular chloride channel activity
0.33	GO:0022839	ion gated channel activity
0.33	GO:0008381	mechanosensitive ion channel activity

0.49	GO:0005737	cytoplasm
0.39	GO:0030496	midbody
0.39	GO:0031968	organelle outer membrane
0.38	GO:0043234	protein complex
0.38	GO:0043231	intracellular membrane-bounded organelle
0.37	GO:0097708	intracellular vesicle
0.37	GO:0031984	organelle subcompartment
0.37	GO:0012505	endomembrane system
0.36	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

tr|T1FXU7|T1FXU7_HELRO
Uncharacterized protein
Search

0.66	Carbon catabolite derepressing protein kinase

0.63	GO:0006468	protein phosphorylation
0.43	GO:0030010	establishment of cell polarity
0.42	GO:0000226	microtubule cytoskeleton organization
0.38	GO:0035556	intracellular signal transduction
0.36	GO:0007049	cell cycle
0.36	GO:0018209	peptidyl-serine modification
0.34	GO:0016570	histone modification
0.34	GO:0048523	negative regulation of cellular process
0.34	GO:0006915	apoptotic process
0.34	GO:0010078	maintenance of root meristem identity

0.64	GO:0004672	protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0005509	calcium ion binding
0.35	GO:2001070	starch binding
0.34	GO:0005516	calmodulin binding
0.33	GO:0018024	histone-lysine N-methyltransferase activity
0.33	GO:0004197	cysteine-type endopeptidase activity

0.38	GO:0005634	nucleus
0.35	GO:0005737	cytoplasm
0.34	GO:0051286	cell tip
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.34	GO:0032178	medial membrane band
0.33	GO:0031588	nucleotide-activated protein kinase complex
0.33	GO:0070013	intracellular organelle lumen
0.33	GO:0030427	site of polarized growth
0.33	GO:0098590	plasma membrane region
0.32	GO:0044446	intracellular organelle part

0.33

GO:0018024

tr|T1FXU8|T1FXU8_HELRO
Uncharacterized protein
Search

0.30

GO:0044425

membrane part

tr|T1FXU9|T1FXU9_HELRO
Uncharacterized protein
Search

FPGS

0.58	Folylpolyglutamate synthase

0.76	GO:0046901	tetrahydrofolylpolyglutamate biosynthetic process
0.65	GO:0006730	one-carbon metabolic process
0.46	GO:0006536	glutamate metabolic process
0.36	GO:0008283	cell proliferation
0.35	GO:0031100	animal organ regeneration
0.35	GO:0001889	liver development
0.34	GO:0007420	brain development
0.34	GO:0046655	folic acid metabolic process
0.32	GO:0006139	nucleobase-containing compound metabolic process

0.76	GO:0004326	tetrahydrofolylpolyglutamate synthase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0008841	dihydrofolate synthase activity
0.34	GO:0046872	metal ion binding

0.42	GO:0005739	mitochondrion
0.36	GO:0031974	membrane-enclosed lumen
0.35	GO:0019866	organelle inner membrane
0.35	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.76

EC:6.3.2.17

GO:0004326

tr|T1FXV0|T1FXV0_HELRO
Sodium/hydrogen exchanger
Search

0.59	Sodium/hydrogen exchanger

0.79	GO:0006885	regulation of pH
0.77	GO:0035725	sodium ion transmembrane transport
0.63	GO:1902600	hydrogen ion transmembrane transport
0.43	GO:0099587	inorganic ion import across plasma membrane
0.42	GO:0030004	cellular monovalent inorganic cation homeostasis
0.40	GO:0071805	potassium ion transmembrane transport
0.34	GO:0010506	regulation of autophagy
0.33	GO:0043401	steroid hormone mediated signaling pathway
0.32	GO:0006351	transcription, DNA-templated
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process

0.82	GO:0015385	sodium:proton antiporter activity
0.43	GO:0015386	potassium:proton antiporter activity
0.33	GO:0003676	nucleic acid binding
0.32	GO:0008270	zinc ion binding
0.32	GO:0003700	DNA binding transcription factor activity

0.42	GO:0055037	recycling endosome
0.36	GO:0005886	plasma membrane
0.33	GO:0005615	extracellular space
0.32	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

tr|T1FXV1|T1FXV1_HELRO
Uncharacterized protein
Search

tr|T1FXV2|T1FXV2_HELRO
Uncharacterized protein
Search

0.27	Putative Pre-mRNA-splicing regulator female-lethal(2)D

0.84	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.80	GO:0080009	mRNA methylation

0.61

GO:0005634

nucleus

tr|T1FXV3|T1FXV3_HELRO
Uncharacterized protein
Search

0.48	GO:0048255	mRNA stabilization
0.48	GO:0060965	negative regulation of gene silencing by miRNA
0.46	GO:2000036	regulation of stem cell population maintenance
0.45	GO:0036093	germ cell proliferation
0.44	GO:0060856	establishment of blood-brain barrier
0.42	GO:0048477	oogenesis
0.38	GO:0045766	positive regulation of angiogenesis
0.37	GO:0009653	anatomical structure morphogenesis
0.36	GO:0008298	intracellular mRNA localization
0.35	GO:0009790	embryo development

0.59	GO:0003723	RNA binding
0.44	GO:0019901	protein kinase binding
0.44	GO:0042803	protein homodimerization activity
0.35	GO:0004525	ribonuclease III activity
0.32	GO:0016491	oxidoreductase activity

0.42	GO:0005654	nucleoplasm
0.42	GO:0005829	cytosol
0.39	GO:1990904	ribonucleoprotein complex
0.35	GO:0005938	cell cortex
0.33	GO:0019013	viral nucleocapsid
0.30	GO:0031224	intrinsic component of membrane

0.35

EC:3.1.26.3

GO:0004525

tr|T1FXV4|T1FXV4_HELRO
Uncharacterized protein
Search

LITAF

0.76	Lipopolysaccharide-induced tumor necrosis factor-alpha factor

0.32

GO:0046872

metal ion binding

0.34	GO:0031902	late endosome membrane
0.34	GO:0005765	lysosomal membrane
0.30	GO:0044425	membrane part

tr|T1FXV5|T1FXV5_HELRO
Uncharacterized protein
Search

MRPL15

0.91	Mitochondrial ribosomal protein L15

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.48	GO:1990830	cellular response to leukemia inhibitory factor
0.34	GO:0000002	mitochondrial genome maintenance
0.33	GO:0043624	cellular protein complex disassembly

0.64	GO:0003735	structural constituent of ribosome
0.34	GO:0003723	RNA binding
0.33	GO:0005515	protein binding

0.71	GO:0015934	large ribosomal subunit
0.50	GO:0005761	mitochondrial ribosome
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0019866	organelle inner membrane

tr|T1FXV6|T1FXV6_HELRO
Uncharacterized protein
Search

tr|T1FXV7|T1FXV7_HELRO
Uncharacterized protein
Search

DHX9

0.86	LOW QUALITY PROTEIN: ATP-dependent RNA helicase A

0.59	GO:1905698	positive regulation of polysome binding
0.58	GO:1904973	positive regulation of viral translation
0.57	GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
0.57	GO:0046833	positive regulation of RNA export from nucleus
0.57	GO:0039695	DNA-templated viral transcription
0.57	GO:0035549	positive regulation of interferon-beta secretion
0.57	GO:2000767	positive regulation of cytoplasmic translation
0.57	GO:0030423	targeting of mRNA for destruction involved in RNA interference
0.57	GO:1904469	positive regulation of tumor necrosis factor secretion
0.56	GO:0070934	CRD-mediated mRNA stabilization

0.67	GO:0004386	helicase activity
0.59	GO:1905172	RISC complex binding
0.58	GO:1905538	polysome binding
0.58	GO:0001069	regulatory region RNA binding
0.57	GO:0045142	triplex DNA binding
0.57	GO:1990825	sequence-specific mRNA binding
0.57	GO:0061676	importin-alpha family protein binding
0.56	GO:0035613	RNA stem-loop binding
0.55	GO:1990841	promoter-specific chromatin binding
0.55	GO:0035197	siRNA binding

0.57	GO:0005726	perichromatin fibrils
0.57	GO:0097165	nuclear stress granule
0.57	GO:0070937	CRD-mediated mRNA stability complex
0.56	GO:0070578	RISC-loading complex
0.55	GO:0035068	micro-ribonucleoprotein complex
0.54	GO:0042788	polysomal ribosome
0.51	GO:0036464	cytoplasmic ribonucleoprotein granule
0.51	GO:0016604	nuclear body
0.50	GO:0005813	centrosome
0.49	GO:0015629	actin cytoskeleton

0.50

EC:3.6.1.19

GO:0047429

tr|T1FXV8|T1FXV8_HELRO
Uncharacterized protein
Search

DET1

0.97	Abnormal oocyte

0.83	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.71	GO:0016567	protein ubiquitination
0.68	GO:0006461	protein complex assembly

0.87	GO:1990756	protein binding, bridging involved in substrate recognition for ubiquitination
0.78	GO:0031625	ubiquitin protein ligase binding
0.73	GO:0032403	protein complex binding

0.85	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex
0.39	GO:0005634	nucleus

tr|T1FXV9|T1FXV9_HELRO
Uncharacterized protein
Search

0.51	GO:0008049	male courtship behavior
0.49	GO:0050684	regulation of mRNA processing
0.39	GO:0043484	regulation of RNA splicing
0.39	GO:0035150	regulation of tube size
0.39	GO:0002064	epithelial cell development
0.39	GO:0045664	regulation of neuron differentiation
0.38	GO:0043412	macromolecule modification
0.37	GO:0023051	regulation of signaling
0.37	GO:0044267	cellular protein metabolic process
0.37	GO:0008608	attachment of spindle microtubules to kinetochore

0.52	GO:0003723	RNA binding
0.38	GO:0004842	ubiquitin-protein transferase activity
0.37	GO:0016788	hydrolase activity, acting on ester bonds
0.37	GO:0004386	helicase activity
0.37	GO:0005515	protein binding
0.36	GO:0046872	metal ion binding
0.36	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting
0.36	GO:0097367	carbohydrate derivative binding
0.35	GO:0030554	adenyl nucleotide binding
0.35	GO:0004965	G-protein coupled GABA receptor activity

0.39	GO:0016607	nuclear speck
0.38	GO:1990225	rhoptry neck
0.38	GO:0005737	cytoplasm
0.36	GO:0000776	kinetochore
0.36	GO:0070847	core mediator complex
0.36	GO:1990298	bub1-bub3 complex
0.36	GO:0033597	mitotic checkpoint complex
0.35	GO:0016592	mediator complex
0.34	GO:0031968	organelle outer membrane
0.30	GO:0016021	integral component of membrane

0.37	EC:3.1	GO:0016788
0.38	KEGG:R03876	GO:0004842

tr|T1FXW0|T1FXW0_HELRO
Uncharacterized protein
Search

0.61	GO:0006508	proteolysis
0.35	GO:0048856	anatomical structure development
0.35	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing
0.35	GO:1902741	positive regulation of interferon-alpha secretion
0.35	GO:0060340	positive regulation of type I interferon-mediated signaling pathway
0.34	GO:0050691	regulation of defense response to virus by host
0.34	GO:0098586	cellular response to virus
0.34	GO:0032501	multicellular organismal process
0.34	GO:0006606	protein import into nucleus
0.34	GO:0000122	negative regulation of transcription by RNA polymerase II

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.34	GO:0005518	collagen binding
0.34	GO:0001047	core promoter binding
0.33	GO:0005509	calcium ion binding
0.33	GO:0043565	sequence-specific DNA binding

0.74	GO:0031012	extracellular matrix
0.35	GO:0031225	anchored component of membrane
0.34	GO:0005634	nucleus
0.33	GO:0005615	extracellular space
0.33	GO:0005886	plasma membrane
0.32	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.70

GO:0004222

tr|T1FXW1|T1FXW1_HELRO
Sodium channel protein
Search

0.55	Sodium channel protein type 11 subunit alpha

0.76	GO:0034765	regulation of ion transmembrane transport
0.76	GO:0035725	sodium ion transmembrane transport
0.55	GO:0019233	sensory perception of pain
0.45	GO:0001508	action potential
0.45	GO:0035637	multicellular organismal signaling
0.43	GO:0051930	regulation of sensory perception of pain
0.42	GO:0051899	membrane depolarization
0.39	GO:0036269	swimming behavior
0.38	GO:0007267	cell-cell signaling
0.38	GO:0002082	regulation of oxidative phosphorylation

0.84	GO:0005248	voltage-gated sodium channel activity
0.74	GO:0022832	voltage-gated channel activity
0.71	GO:0022839	ion gated channel activity
0.71	GO:0008381	mechanosensitive ion channel activity
0.51	GO:0005509	calcium ion binding
0.37	GO:0044325	ion channel binding
0.33	GO:0005267	potassium channel activity
0.33	GO:0008081	phosphoric diester hydrolase activity

0.82	GO:0001518	voltage-gated sodium channel complex
0.45	GO:0044299	C-fiber
0.36	GO:0070062	extracellular exosome
0.35	GO:0071439	clathrin complex
0.33	GO:0008076	voltage-gated potassium channel complex

0.33

EC:3.1.4

GO:0008081

tr|T1FXW2|T1FXW2_HELRO
Uncharacterized protein
Search

0.11	Putative RNA-binding protein 15B

0.43	GO:0007221	positive regulation of transcription of Notch receptor target
0.42	GO:0060412	ventricular septum morphogenesis
0.42	GO:0001569	branching involved in blood vessel morphogenesis
0.42	GO:0048536	spleen development
0.42	GO:0045638	negative regulation of myeloid cell differentiation
0.40	GO:0000122	negative regulation of transcription by RNA polymerase II
0.40	GO:0060674	placenta blood vessel development
0.39	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.38	GO:0000398	mRNA splicing, via spliceosome
0.35	GO:0009190	cyclic nucleotide biosynthetic process

0.59	GO:0003723	RNA binding
0.35	GO:0016849	phosphorus-oxygen lyase activity
0.34	GO:0005515	protein binding
0.33	GO:0005249	voltage-gated potassium channel activity

0.41	GO:0016607	nuclear speck
0.33	GO:0008076	voltage-gated potassium channel complex
0.33	GO:0016589	NURF complex
0.33	GO:0005730	nucleolus

0.35

EC:4.6

GO:0016849

tr|T1FXW3|T1FXW3_HELRO
Uncharacterized protein
Search

1433E

0.71	Multifunctional chaperone

0.38	GO:0007280	pole cell migration
0.38	GO:0008103	oocyte microtubule cytoskeleton polarization
0.38	GO:0007294	germarium-derived oocyte fate determination
0.38	GO:0048190	wing disc dorsal/ventral pattern formation
0.37	GO:0008340	determination of adult lifespan
0.37	GO:0045927	positive regulation of growth
0.37	GO:0009411	response to UV
0.37	GO:0007411	axon guidance
0.37	GO:0000077	DNA damage checkpoint
0.37	GO:0007088	regulation of mitotic nuclear division

0.77	GO:0019904	protein domain specific binding
0.38	GO:0050815	phosphoserine residue binding
0.36	GO:0046982	protein heterodimerization activity
0.33	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0017171	serine hydrolase activity
0.33	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.33	GO:0016301	kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.38	GO:0045172	germline ring canal
0.35	GO:0005694	chromosome
0.34	GO:0005634	nucleus
0.33	GO:0005737	cytoplasm

0.33

GO:0016773

tr|T1FXW4|T1FXW4_HELRO
Uncharacterized protein
Search

0.57	Dopamine receptor, invertebrate (Fragment)

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.44	GO:0007210	serotonin receptor signaling pathway
0.37	GO:0007610	behavior
0.37	GO:0032417	positive regulation of sodium:proton antiporter activity
0.37	GO:0034776	response to histamine
0.36	GO:0060080	inhibitory postsynaptic potential
0.36	GO:0042053	regulation of dopamine metabolic process
0.36	GO:0001975	response to amphetamine
0.36	GO:1901386	negative regulation of voltage-gated calcium channel activity
0.36	GO:0042220	response to cocaine

0.72	GO:0004930	G-protein coupled receptor activity
0.59	GO:0030594	neurotransmitter receptor activity
0.44	GO:0099589	serotonin receptor activity
0.44	GO:0001653	peptide receptor activity
0.43	GO:0051378	serotonin binding
0.37	GO:0051380	norepinephrine binding
0.37	GO:0051379	epinephrine binding
0.36	GO:0035240	dopamine binding
0.36	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.35	GO:0017124	SH3 domain binding

0.49	GO:0005887	integral component of plasma membrane
0.36	GO:0098794	postsynapse
0.35	GO:0098793	presynapse
0.34	GO:0012506	vesicle membrane
0.34	GO:0044309	neuron spine
0.34	GO:0070382	exocytic vesicle
0.34	GO:0044306	neuron projection terminus
0.33	GO:0033267	axon part
0.33	GO:0097060	synaptic membrane
0.33	GO:0043025	neuronal cell body

0.36

GO:0004715

tr|T1FXW5|T1FXW5_HELRO
Uncharacterized protein
Search

LOC108737224

0.30	Tyrosine-protein phosphatase non-receptor type 9

0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.43	GO:0007298	border follicle cell migration
0.41	GO:0018108	peptidyl-tyrosine phosphorylation
0.34	GO:1903078	positive regulation of protein localization to plasma membrane
0.34	GO:0010977	negative regulation of neuron projection development
0.34	GO:0071345	cellular response to cytokine stimulus

0.74	GO:0004725	protein tyrosine phosphatase activity
0.35	GO:0050254	rhodopsin kinase activity
0.34	GO:0005515	protein binding
0.32	GO:0016779	nucleotidyltransferase activity

0.44	GO:0044306	neuron projection terminus
0.36	GO:0005829	cytosol
0.33	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.74

GO:0004725

tr|T1FXW6|T1FXW6_HELRO
Uncharacterized protein
Search

COPZ1

0.87	Coatomer protein complex subunit zeta

0.65	GO:0015031	protein transport
0.60	GO:0016192	vesicle-mediated transport
0.60	GO:0046907	intracellular transport
0.59	GO:0034613	cellular protein localization
0.46	GO:1901998	toxin transport
0.42	GO:0002088	lens development in camera-type eye
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.33	GO:0043565	sequence-specific DNA binding
0.32	GO:0003723	RNA binding

0.66	GO:0030117	membrane coat
0.50	GO:0030663	COPI-coated vesicle membrane
0.47	GO:0044431	Golgi apparatus part
0.37	GO:0031984	organelle subcompartment
0.36	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
0.35	GO:0030133	transport vesicle
0.35	GO:0005829	cytosol
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.34	GO:0044432	endoplasmic reticulum part
0.34	GO:0005801	cis-Golgi network

tr|T1FXW7|T1FXW7_HELRO
Uncharacterized protein
Search

N6AMT1

0.43	S-adenosyl-L-methionine-dependent methyltransferase

0.71	GO:0008213	protein alkylation
0.65	GO:0043414	macromolecule methylation
0.49	GO:0006417	regulation of translation
0.40	GO:0030307	positive regulation of cell growth
0.34	GO:0006415	translational termination

0.71	GO:0008276	protein methyltransferase activity
0.51	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
0.49	GO:0003676	nucleic acid binding
0.33	GO:0005515	protein binding

0.57	GO:0035657	eRF1 methyltransferase complex
0.36	GO:0005737	cytoplasm
0.36	GO:0043234	protein complex

0.71

GO:0008276

tr|T1FXW8|T1FXW8_HELRO
Uncharacterized protein
Search

TIMM50

0.74	Translocase of inner mitochondrial membrane 50

0.65	GO:0015031	protein transport
0.49	GO:0007005	mitochondrion organization
0.46	GO:0006470	protein dephosphorylation
0.46	GO:0097190	apoptotic signaling pathway
0.45	GO:1990542	mitochondrial transmembrane transport
0.44	GO:0072655	establishment of protein localization to mitochondrion
0.42	GO:0061024	membrane organization
0.42	GO:0046907	intracellular transport
0.33	GO:0007186	G-protein coupled receptor signaling pathway

0.48	GO:0005134	interleukin-2 receptor binding
0.46	GO:0004721	phosphoprotein phosphatase activity
0.43	GO:0043021	ribonucleoprotein complex binding
0.40	GO:0008566	mitochondrial protein-transporting ATPase activity
0.33	GO:0004930	G-protein coupled receptor activity
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0003723	RNA binding
0.32	GO:0032555	purine ribonucleotide binding

0.82	GO:0005744	mitochondrial inner membrane presequence translocase complex
0.45	GO:0016607	nuclear speck
0.30	GO:0031224	intrinsic component of membrane

0.46

GO:0004721

tr|T1FXW9|T1FXW9_HELRO
Uncharacterized protein
Search

tr|T1FXX0|T1FXX0_HELRO
Uncharacterized protein
Search

0.55	Ran-binding protein homolog (Fragment)

0.69	GO:0046907	intracellular transport
0.64	GO:0000413	protein peptidyl-prolyl isomerization
0.57	GO:0006457	protein folding
0.54	GO:0006606	protein import into nucleus
0.54	GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis
0.53	GO:0033133	positive regulation of glucokinase activity
0.51	GO:0046604	positive regulation of mitotic centrosome separation
0.51	GO:0051642	centrosome localization
0.49	GO:0016925	protein sumoylation
0.48	GO:0000082	G1/S transition of mitotic cell cycle

0.64	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.52	GO:0008536	Ran GTPase binding
0.48	GO:0046872	metal ion binding
0.46	GO:0016874	ligase activity
0.46	GO:0005096	GTPase activator activity
0.35	GO:0044877	macromolecular complex binding
0.35	GO:0019789	SUMO transferase activity
0.34	GO:0031490	chromatin DNA binding
0.34	GO:0004930	G-protein coupled receptor activity
0.34	GO:0003723	RNA binding

0.53	GO:0005642	annulate lamellae
0.51	GO:0042405	nuclear inclusion body
0.51	GO:0044614	nuclear pore cytoplasmic filaments
0.51	GO:0044615	nuclear pore nuclear basket
0.48	GO:0031965	nuclear membrane
0.46	GO:0005813	centrosome
0.41	GO:0005739	mitochondrion
0.36	GO:1990723	cytoplasmic periphery of the nuclear pore complex
0.34	GO:0005829	cytosol
0.34	GO:0000785	chromatin

0.64

GO:0003755

tr|T1FXX1|T1FXX1_HELRO
Uncharacterized protein
Search

0.55

GO:0003677

DNA binding

tr|T1FXX2|T1FXX2_HELRO
Uncharacterized protein
Search

0.71	Calcium-activated BK potassium channel alpha subunit

0.73	GO:0071805	potassium ion transmembrane transport
0.44	GO:0043050	pharyngeal pumping
0.43	GO:0048149	behavioral response to ethanol
0.42	GO:0046928	regulation of neurotransmitter secretion
0.42	GO:0045214	sarcomere organization
0.38	GO:0040011	locomotion
0.34	GO:0034765	regulation of ion transmembrane transport

0.85	GO:0060072	large conductance calcium-activated potassium channel activity
0.77	GO:0005249	voltage-gated potassium channel activity
0.36	GO:0005515	protein binding
0.32	GO:0046872	metal ion binding

0.77	GO:0008076	voltage-gated potassium channel complex
0.43	GO:0055120	striated muscle dense body
0.43	GO:0031430	M band
0.40	GO:0045202	synapse
0.34	GO:0030054	cell junction

tr|T1FXX4|T1FXX4_HELRO
Uncharacterized protein
Search

PTRH2

0.62	Mitochondrial peptidyl-tRNA hydrolase 2

0.39	GO:2000210	positive regulation of anoikis
0.38	GO:2000811	negative regulation of anoikis
0.35	GO:0010629	negative regulation of gene expression
0.34	GO:0006915	apoptotic process
0.32	GO:0016310	phosphorylation

0.79	GO:0004045	aminoacyl-tRNA hydrolase activity
0.34	GO:0005515	protein binding
0.32	GO:0016301	kinase activity

0.43	GO:0005739	mitochondrion
0.35	GO:0005829	cytosol
0.30	GO:0044425	membrane part

0.79

EC:3.1.1.29

GO:0004045

tr|T1FXX5|T1FXX5_HELRO
Uncharacterized protein
Search

0.48	Testis-specific kinase 2

0.63	GO:0006468	protein phosphorylation
0.47	GO:0045501	regulation of sevenless signaling pathway
0.47	GO:0045677	negative regulation of R7 cell differentiation
0.45	GO:0010454	negative regulation of cell fate commitment
0.44	GO:0001700	embryonic development via the syncytial blastoderm
0.42	GO:0030036	actin cytoskeleton organization
0.41	GO:0097435	supramolecular fiber organization
0.41	GO:0009968	negative regulation of signal transduction
0.39	GO:0035556	intracellular signal transduction
0.38	GO:0018212	peptidyl-tyrosine modification

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0004871	signal transducer activity
0.39	GO:0046872	metal ion binding
0.34	GO:0030942	endoplasmic reticulum signal peptide binding
0.34	GO:0005047	signal recognition particle binding
0.34	GO:0008312	7S RNA binding
0.32	GO:0099600	transmembrane receptor activity

0.46	GO:0016604	nuclear body
0.43	GO:0045177	apical part of cell
0.37	GO:0005737	cytoplasm
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0016020	membrane

tr|T1FXX6|T1FXX6_HELRO
Succinate dehydrogenase assembly factor 2, mitochondrial
Search

0.74	Succinate dehydrogenase assembly factor 2-A, mitochondrial

0.85	GO:0018293	protein-FAD linkage
0.85	GO:0006121	mitochondrial electron transport, succinate to ubiquinone
0.43	GO:0097032	mitochondrial respiratory chain complex II biogenesis
0.43	GO:0034552	respiratory chain complex II assembly
0.41	GO:0033108	mitochondrial respiratory chain complex assembly
0.39	GO:0006099	tricarboxylic acid cycle
0.37	GO:0017013	protein flavinylation
0.33	GO:0006334	nucleosome assembly

0.32	GO:0016491	oxidoreductase activity
0.32	GO:0003677	DNA binding

0.75	GO:0005759	mitochondrial matrix
0.33	GO:0000786	nucleosome
0.33	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016491

tr|T1FXX7|T1FXX7_HELRO
Uncharacterized protein
Search

0.54	Mitogen-activated protein kinase kinase kinase 13

0.80	GO:0000186	activation of MAPKK activity
0.78	GO:0046777	protein autophosphorylation
0.76	GO:0000165	MAPK cascade
0.67	GO:0031098	stress-activated protein kinase signaling cascade
0.56	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.40	GO:2000672	negative regulation of motor neuron apoptotic process
0.39	GO:0016572	histone phosphorylation
0.39	GO:0018107	peptidyl-threonine phosphorylation
0.38	GO:0018105	peptidyl-serine phosphorylation

0.81	GO:0004709	MAP kinase kinase kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0042803	protein homodimerization activity
0.39	GO:0046872	metal ion binding
0.39	GO:0019901	protein kinase binding

0.54	GO:0008385	IkappaB kinase complex
0.39	GO:0030426	growth cone
0.38	GO:0030424	axon
0.34	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.81

EC:2.7.11 EC:2.7.11.25

GO:0004709

tr|T1FXX8|T1FXX8_HELRO
Uncharacterized protein
Search

SERP2

0.74	stress-associated endoplasmic reticulum protein 2

0.54	GO:0015031	protein transport
0.51	GO:0030968	endoplasmic reticulum unfolded protein response
0.47	GO:0060124	positive regulation of growth hormone secretion
0.45	GO:0046622	positive regulation of organ growth
0.45	GO:0006486	protein glycosylation
0.45	GO:0032024	positive regulation of insulin secretion
0.45	GO:0048644	muscle organ morphogenesis
0.45	GO:0010259	multicellular organism aging
0.44	GO:0001501	skeletal system development
0.43	GO:0009791	post-embryonic development

0.34	GO:0003735	structural constituent of ribosome
0.34	GO:0005515	protein binding

0.70	GO:0005783	endoplasmic reticulum
0.58	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.56	GO:0031984	organelle subcompartment
0.45	GO:0005881	cytoplasmic microtubule
0.34	GO:0015935	small ribosomal subunit
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1FXX9|T1FXX9_HELRO
Uncharacterized protein
Search

LITAF

0.84	Lipopolysaccharide-induced tumor necrosis factor-alpha factor

0.41	GO:0042347	negative regulation of NF-kappaB import into nucleus
0.40	GO:0071222	cellular response to lipopolysaccharide
0.39	GO:0001817	regulation of cytokine production
0.38	GO:0045944	positive regulation of transcription by RNA polymerase II
0.35	GO:0001816	cytokine production
0.34	GO:0006351	transcription, DNA-templated
0.34	GO:0019953	sexual reproduction
0.34	GO:0010469	regulation of receptor activity

0.40	GO:0050699	WW domain binding
0.39	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.38	GO:0008270	zinc ion binding
0.34	GO:0005125	cytokine activity

0.44	GO:0098560	cytoplasmic side of late endosome membrane
0.44	GO:0098559	cytoplasmic side of early endosome membrane
0.44	GO:0098574	cytoplasmic side of lysosomal membrane
0.40	GO:0009898	cytoplasmic side of plasma membrane
0.39	GO:0005794	Golgi apparatus
0.37	GO:0005654	nucleoplasm
0.37	GO:0005829	cytosol
0.35	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

tr|T1FXY0|T1FXY0_HELRO
Uncharacterized protein
Search

0.42	GO:0048916	posterior lateral line development
0.41	GO:0007166	cell surface receptor signaling pathway
0.35	GO:0014005	microglia development
0.35	GO:0014002	astrocyte development
0.35	GO:0048709	oligodendrocyte differentiation
0.35	GO:0042552	myelination
0.34	GO:0006954	inflammatory response
0.34	GO:0061564	axon development
0.34	GO:0007283	spermatogenesis
0.33	GO:0006631	fatty acid metabolic process

0.33	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
0.33	GO:0004152	dihydroorotate dehydrogenase activity

0.40	GO:0005887	integral component of plasma membrane
0.35	GO:0043209	myelin sheath
0.34	GO:0009986	cell surface
0.31	GO:0005737	cytoplasm

0.33	EC:1.1.1.35	GO:0003857
0.33	KEGG:R01868	GO:0004152

tr|T1FXY1|T1FXY1_HELRO
Uncharacterized protein
Search

0.74	Myosin essential light chain, striated adductor muscle

0.70

GO:0005509

calcium ion binding

0.44	GO:0016459	myosin complex
0.37	GO:0036379	myofilament
0.37	GO:0030017	sarcomere
0.30	GO:0031224	intrinsic component of membrane

tr|T1FXY2|T1FXY2_HELRO
Uncharacterized protein
Search

0.86	Beta thymosin

0.75	GO:0007015	actin filament organization
0.35	GO:0007399	nervous system development

0.85

GO:0003785

actin monomer binding

0.34	GO:0005829	cytosol
0.33	GO:0005634	nucleus

tr|T1FXY3|T1FXY3_HELRO
Uncharacterized protein
Search

0.53	Helix-loop-helix protein 13 (inferred by orthology to a C. elegans protein)

0.46	GO:1903204	negative regulation of oxidative stress-induced neuron death
0.46	GO:0045475	locomotor rhythm
0.43	GO:0006979	response to oxidative stress
0.43	GO:0048699	generation of neurons
0.42	GO:0010628	positive regulation of gene expression
0.40	GO:0071981	exit from diapause
0.39	GO:0040024	dauer larval development
0.39	GO:0008286	insulin receptor signaling pathway
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process

0.68	GO:0046983	protein dimerization activity
0.37	GO:0008134	transcription factor binding
0.36	GO:0003677	DNA binding

0.33	GO:0005856	cytoskeleton
0.33	GO:0005634	nucleus
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1FXY4|T1FXY4_HELRO
Uncharacterized protein
Search

0.67	Calcium-binding mitochondrial carrier protein SCaMC-1-A

0.55	GO:0055085	transmembrane transport
0.49	GO:0015867	ATP transport
0.46	GO:0015866	ADP transport
0.46	GO:0006839	mitochondrial transport
0.42	GO:0071277	cellular response to calcium ion
0.39	GO:0034599	cellular response to oxidative stress
0.39	GO:0010941	regulation of cell death
0.37	GO:0032094	response to food
0.37	GO:0002021	response to dietary excess
0.37	GO:0014823	response to activity

0.67	GO:0005509	calcium ion binding
0.49	GO:0005347	ATP transmembrane transporter activity
0.46	GO:0015217	ADP transmembrane transporter activity
0.35	GO:0016746	transferase activity, transferring acyl groups
0.35	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.33	GO:0043565	sequence-specific DNA binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0003700	DNA binding transcription factor activity
0.32	GO:0003723	RNA binding

0.56	GO:0031966	mitochondrial membrane
0.56	GO:0019866	organelle inner membrane
0.34	GO:0070062	extracellular exosome
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.35

GO:0016746

tr|T1FXY5|T1FXY5_HELRO
Uncharacterized protein
Search

0.67	AT-rich interactive domain-containing protein 3A (Fragment)

0.51	GO:0045893	positive regulation of transcription, DNA-templated
0.49	GO:0006366	transcription by RNA polymerase II
0.49	GO:0006357	regulation of transcription by RNA polymerase II
0.40	GO:0045924	regulation of female receptivity
0.40	GO:0008049	male courtship behavior
0.39	GO:0048813	dendrite morphogenesis
0.39	GO:0009880	embryonic pattern specification
0.39	GO:0042063	gliogenesis
0.39	GO:0009952	anterior/posterior pattern specification
0.39	GO:0007517	muscle organ development

0.55	GO:0003677	DNA binding
0.52	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.51	GO:0001067	regulatory region nucleic acid binding
0.49	GO:0003682	chromatin binding
0.46	GO:0042803	protein homodimerization activity
0.39	GO:0070491	repressing transcription factor binding
0.34	GO:0004605	phosphatidate cytidylyltransferase activity
0.33	GO:0004930	G-protein coupled receptor activity

0.61	GO:0005634	nucleus
0.50	GO:0045121	membrane raft
0.44	GO:0005829	cytosol
0.43	GO:0043233	organelle lumen
0.40	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

0.34

EC:2.7.7.41

GO:0004605

tr|T1FXY6|T1FXY6_HELRO
Uncharacterized protein
Search

0.86	Putative vacuolar assembly/sorting protein vps9 (Fragment)

0.75	GO:0043087	regulation of GTPase activity
0.61	GO:0007165	signal transduction

0.35

GO:0046982

protein heterodimerization activity

0.33	GO:0005634	nucleus
0.30	GO:0044425	membrane part

tr|T1FXY7|T1FXY7_HELRO
Uncharacterized protein
Search

0.89	Gonadal protein gdl (Fragment)

tr|T1FXY8|T1FXY8_HELRO
Protein kinase C
Search

0.10	Protein kinase C eta type

0.63	GO:0006468	protein phosphorylation
0.62	GO:0035556	intracellular signal transduction
0.43	GO:0018209	peptidyl-serine modification
0.36	GO:0050893	sensory processing
0.35	GO:1902074	response to salt
0.35	GO:0048009	insulin-like growth factor receptor signaling pathway
0.35	GO:0050975	sensory perception of touch
0.35	GO:0040024	dauer larval development
0.35	GO:0050927	positive regulation of positive chemotaxis
0.35	GO:2001024	negative regulation of response to drug

0.83	GO:0004697	protein kinase C activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0046872	metal ion binding

0.45	GO:0005622	intracellular
0.34	GO:0098793	presynapse
0.30	GO:0016020	membrane

0.83

EC:2.7.11.13

GO:0004697

tr|T1FXY9|T1FXY9_HELRO
Uncharacterized protein
Search

0.50	Potassium voltage-gated channel protein Shaw

0.78	GO:0051260	protein homooligomerization
0.78	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.35	GO:0030431	sleep
0.34	GO:0006379	mRNA cleavage
0.32	GO:0006351	transcription, DNA-templated

0.78	GO:0005249	voltage-gated potassium channel activity
0.35	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.33	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.33	GO:0046872	metal ion binding
0.32	GO:0003676	nucleic acid binding

0.78

GO:0008076

voltage-gated potassium channel complex

0.35

EC:3.1.4.17

GO:0004114

tr|T1FXZ0|T1FXZ0_HELRO
Uncharacterized protein
Search

0.59	Forkhead box protein O6

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.54	GO:0006351	transcription, DNA-templated
0.48	GO:0071455	cellular response to hyperoxia
0.47	GO:0032873	negative regulation of stress-activated MAPK cascade
0.45	GO:0060999	positive regulation of dendritic spine development
0.45	GO:0042981	regulation of apoptotic process
0.45	GO:0045732	positive regulation of protein catabolic process
0.45	GO:0048856	anatomical structure development

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.46	GO:0008013	beta-catenin binding
0.44	GO:0031625	ubiquitin protein ligase binding
0.43	GO:0051721	protein phosphatase 2A binding
0.39	GO:0000989	transcription factor activity, transcription factor binding
0.39	GO:0008134	transcription factor binding
0.36	GO:0044212	transcription regulatory region DNA binding
0.36	GO:0003690	double-stranded DNA binding
0.33	GO:0003682	chromatin binding

0.61	GO:0005634	nucleus
0.38	GO:0005737	cytoplasm
0.34	GO:0070013	intracellular organelle lumen
0.33	GO:0005578	proteinaceous extracellular matrix
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.32	EC:5.3.1.6	GO:0004751
0.32	KEGG:R01056	GO:0004751

tr|T1FXZ1|T1FXZ1_HELRO
Uncharacterized protein
Search

0.59	GO:0007219	Notch signaling pathway
0.53	GO:0030154	cell differentiation
0.52	GO:0007275	multicellular organism development
0.51	GO:0050793	regulation of developmental process
0.44	GO:0007155	cell adhesion
0.38	GO:0060255	regulation of macromolecule metabolic process
0.38	GO:0048589	developmental growth
0.38	GO:0031323	regulation of cellular metabolic process
0.38	GO:0051171	regulation of nitrogen compound metabolic process
0.38	GO:0080090	regulation of primary metabolic process

0.69	GO:0005509	calcium ion binding
0.40	GO:0060089	molecular transducer activity
0.40	GO:0003682	chromatin binding
0.38	GO:0004252	serine-type endopeptidase activity
0.37	GO:0008270	zinc ion binding
0.35	GO:0030234	enzyme regulator activity
0.35	GO:0005515	protein binding
0.35	GO:0030246	carbohydrate binding
0.34	GO:0044877	macromolecular complex binding
0.34	GO:0008201	heparin binding

0.42	GO:0005576	extracellular region
0.37	GO:0009986	cell surface
0.36	GO:0005886	plasma membrane
0.35	GO:0043235	receptor complex
0.34	GO:0120025	plasma membrane bounded cell projection
0.34	GO:0005634	nucleus
0.34	GO:0005912	adherens junction
0.34	GO:0031254	cell trailing edge
0.34	GO:0098552	side of membrane
0.34	GO:0045178	basal part of cell

0.38

GO:0004252

tr|T1FXZ2|T1FXZ2_HELRO
Uncharacterized protein
Search

tr|T1FXZ3|T1FXZ3_HELRO
Uncharacterized protein
Search

0.46	mTERF domain-containing protein 1, mitochondrial

0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:0010468	regulation of gene expression

0.72

GO:0003690

double-stranded DNA binding

0.30

GO:0044425

membrane part

tr|T1FXZ4|T1FXZ4_HELRO
Uncharacterized protein
Search

0.47	GO:0007219	Notch signaling pathway
0.44	GO:0032502	developmental process
0.43	GO:0032501	multicellular organismal process
0.40	GO:0050793	regulation of developmental process
0.38	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.38	GO:0036060	slit diaphragm assembly
0.37	GO:0010951	negative regulation of endopeptidase activity
0.37	GO:0007186	G-protein coupled receptor signaling pathway
0.37	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
0.37	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity

0.70	GO:0005509	calcium ion binding
0.38	GO:0004867	serine-type endopeptidase inhibitor activity
0.37	GO:0004872	receptor activity
0.37	GO:0005112	Notch binding
0.36	GO:0004871	signal transducer activity
0.36	GO:0004623	phospholipase A2 activity
0.36	GO:0005272	sodium channel activity
0.35	GO:0004725	protein tyrosine phosphatase activity
0.34	GO:0030246	carbohydrate binding
0.34	GO:0008233	peptidase activity

0.36	GO:0005576	extracellular region
0.35	GO:0005768	endosome
0.35	GO:0005886	plasma membrane
0.34	GO:0043025	neuronal cell body
0.34	GO:0030425	dendrite
0.34	GO:0043234	protein complex
0.33	GO:0005903	brush border
0.33	GO:0030139	endocytic vesicle
0.33	GO:0005905	clathrin-coated pit
0.33	GO:0045177	apical part of cell

0.36

EC:3.1.1.4

GO:0004623

tr|T1FXZ5|T1FXZ5_HELRO
Uncharacterized protein
Search

MRPS22

0.69	Small subunit ribosomal protein S22

0.37	GO:0032543	mitochondrial translation
0.35	GO:0035335	peptidyl-tyrosine dephosphorylation
0.35	GO:0006506	GPI anchor biosynthetic process

0.48	GO:0016757	transferase activity, transferring glycosyl groups
0.48	GO:0003735	structural constituent of ribosome
0.35	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.35	GO:0004725	protein tyrosine phosphatase activity

0.58	GO:0005763	mitochondrial small ribosomal subunit
0.51	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.48

GO:0016757

tr|T1FXZ6|T1FXZ6_HELRO
Uncharacterized protein
Search

0.59	ATPase H+ transporting lysosomal protein (Fragment)

0.62	GO:0015992	proton transport
0.55	GO:0055085	transmembrane transport
0.42	GO:0036295	cellular response to increased oxygen levels
0.39	GO:0006879	cellular iron ion homeostasis
0.38	GO:0043068	positive regulation of programmed cell death
0.38	GO:0012501	programmed cell death
0.34	GO:0006754	ATP biosynthetic process

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.41	GO:0051117	ATPase binding
0.39	GO:0022853	active ion transmembrane transporter activity
0.38	GO:0015078	hydrogen ion transmembrane transporter activity

0.83	GO:0016471	vacuolar proton-transporting V-type ATPase complex
0.41	GO:0005765	lysosomal membrane
0.38	GO:0005829	cytosol
0.36	GO:0005886	plasma membrane
0.35	GO:0030285	integral component of synaptic vesicle membrane
0.35	GO:0045177	apical part of cell

tr|T1FXZ7|T1FXZ7_HELRO
Uncharacterized protein
Search

0.31	Rhodopsin like gpcr transmembrane domain protein

0.82	GO:0019236	response to pheromone
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.34	GO:0002943	tRNA dihydrouridine synthesis
0.32	GO:0055114	oxidation-reduction process

0.34	GO:0017150	tRNA dihydrouridine synthase activity
0.33	GO:0050660	flavin adenine dinucleotide binding

0.30

GO:0044425

membrane part

tr|T1FXZ8|T1FXZ8_HELRO
Sulfhydryl oxidase
Search

GFER

0.61	FAD-linked sulfhydryl oxidase ALR

0.52	GO:0055114	oxidation-reduction process
0.47	GO:0001889	liver development
0.41	GO:0007507	heart development
0.38	GO:0045041	protein import into mitochondrial intermembrane space
0.36	GO:0006879	cellular iron ion homeostasis
0.36	GO:0034599	cellular response to oxidative stress
0.34	GO:0010469	regulation of receptor activity

0.84	GO:0016972	thiol oxidase activity
0.47	GO:0015035	protein disulfide oxidoreductase activity
0.45	GO:0050660	flavin adenine dinucleotide binding
0.40	GO:0042803	protein homodimerization activity
0.34	GO:0008083	growth factor activity

0.45	GO:0005739	mitochondrion
0.43	GO:0005829	cytosol
0.38	GO:0031970	organelle envelope lumen
0.34	GO:0005576	extracellular region
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.84

EC:1.8.3.2

GO:0016972

tr|T1FXZ9|T1FXZ9_HELRO
Uncharacterized protein
Search

0.61	Putative glycine cleavage system h protein (Fragment)

tr|T1FY00|T1FY00_HELRO
Uncharacterized protein
Search

0.49	GO:0016310	phosphorylation
0.45	GO:0030001	metal ion transport
0.45	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.40	GO:0006471	protein ADP-ribosylation
0.39	GO:0055085	transmembrane transport
0.39	GO:0009116	nucleoside metabolic process
0.37	GO:0072511	divalent inorganic cation transport
0.37	GO:2000031	regulation of salicylic acid mediated signaling pathway
0.37	GO:0071446	cellular response to salicylic acid stimulus
0.37	GO:0031116	positive regulation of microtubule polymerization

0.51	GO:0016301	kinase activity
0.49	GO:0033897	ribonuclease T2 activity
0.44	GO:0046873	metal ion transmembrane transporter activity
0.41	GO:0003723	RNA binding
0.40	GO:0003950	NAD+ ADP-ribosyltransferase activity
0.38	GO:0005261	cation channel activity
0.36	GO:0140096	catalytic activity, acting on a protein
0.35	GO:0046872	metal ion binding
0.35	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.34	GO:0032559	adenyl ribonucleotide binding

0.36	GO:0005838	proteasome regulatory particle
0.36	GO:0000922	spindle pole
0.35	GO:0005829	cytosol
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.49

EC:3.1.27.1

GO:0033897

tr|T1FY01|T1FY01_HELRO
Uncharacterized protein
Search

TIMM13

0.88	Mitochondrial import inner membrane translocase subunit 13

0.65	GO:0015031	protein transport
0.47	GO:0090151	establishment of protein localization to mitochondrial membrane
0.47	GO:0007007	inner mitochondrial membrane organization
0.46	GO:1990542	mitochondrial transmembrane transport
0.42	GO:0046907	intracellular transport
0.34	GO:0007605	sensory perception of sound

0.54	GO:0046872	metal ion binding
0.43	GO:0008565	protein transporter activity
0.33	GO:0005198	structural molecule activity

0.61	GO:0005739	mitochondrion
0.47	GO:0001650	fibrillar center
0.45	GO:0031970	organelle envelope lumen
0.41	GO:1990351	transporter complex
0.41	GO:0019866	organelle inner membrane
0.35	GO:0005882	intermediate filament
0.30	GO:0016021	integral component of membrane

tr|T1FY02|T1FY02_HELRO
Uncharacterized protein
Search

0.53	Metastasis suppressor protein 1

0.82	GO:0007009	plasma membrane organization
0.68	GO:0097178	ruffle assembly
0.38	GO:0036120	cellular response to platelet-derived growth factor stimulus
0.37	GO:0097581	lamellipodium organization
0.37	GO:0090630	activation of GTPase activity
0.36	GO:0030036	actin cytoskeleton organization
0.35	GO:0072160	nephron tubule epithelial cell differentiation
0.35	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis
0.35	GO:0072102	glomerulus morphogenesis
0.35	GO:0071498	cellular response to fluid shear stress

0.74	GO:0003779	actin binding
0.37	GO:0048365	Rac GTPase binding
0.37	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.36	GO:0005096	GTPase activator activity
0.34	GO:0042802	identical protein binding
0.33	GO:0005102	receptor binding

0.37	GO:0032587	ruffle membrane
0.37	GO:0030027	lamellipodium
0.36	GO:0030864	cortical actin cytoskeleton
0.30	GO:0031224	intrinsic component of membrane

tr|T1FY03|T1FY03_HELRO
Uncharacterized protein
Search

0.10	LSM14A mRNA-processing body assembly factor a

0.73	GO:0033962	cytoplasmic mRNA processing body assembly
0.71	GO:0039529	RIG-I signaling pathway
0.69	GO:0060340	positive regulation of type I interferon-mediated signaling pathway
0.51	GO:0006417	regulation of translation
0.50	GO:0007275	multicellular organism development
0.44	GO:0034249	negative regulation of cellular amide metabolic process
0.42	GO:0032269	negative regulation of cellular protein metabolic process
0.42	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
0.41	GO:0010629	negative regulation of gene expression
0.36	GO:0098655	cation transmembrane transport

0.62	GO:0003727	single-stranded RNA binding
0.60	GO:0003725	double-stranded RNA binding
0.57	GO:0003690	double-stranded DNA binding
0.48	GO:0017151	DEAD/H-box RNA helicase binding
0.39	GO:0003713	transcription coactivator activity
0.36	GO:0008324	cation transmembrane transporter activity

0.71	GO:0000932	P-body
0.71	GO:0010494	cytoplasmic stress granule
0.56	GO:0005829	cytosol
0.35	GO:0043234	protein complex
0.30	GO:0016020	membrane

tr|T1FY04|T1FY04_HELRO
Uncharacterized protein
Search

DUSP22

0.86	Dual specificity protein phosphatase 22-A

0.72	GO:0006470	protein dephosphorylation
0.52	GO:0043408	regulation of MAPK cascade
0.49	GO:0070304	positive regulation of stress-activated protein kinase signaling cascade
0.49	GO:0007179	transforming growth factor beta receptor signaling pathway
0.47	GO:0001934	positive regulation of protein phosphorylation
0.47	GO:0009968	negative regulation of signal transduction
0.47	GO:0042127	regulation of cell proliferation
0.46	GO:0051172	negative regulation of nitrogen compound metabolic process
0.46	GO:0031324	negative regulation of cellular metabolic process
0.46	GO:0002710	negative regulation of T cell mediated immunity

0.78	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.61	GO:0004725	protein tyrosine phosphatase activity
0.46	GO:0033549	MAP kinase phosphatase activity
0.34	GO:0044212	transcription regulatory region DNA binding
0.33	GO:0003700	DNA binding transcription factor activity
0.33	GO:0016301	kinase activity
0.33	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.33	GO:0015002	heme-copper terminal oxidase activity
0.32	GO:0015078	hydrogen ion transmembrane transporter activity
0.32	GO:0005515	protein binding

0.35	GO:0005634	nucleus
0.34	GO:0005829	cytosol
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.78

EC:3.1.3

GO:0008138

tr|T1FY05|T1FY05_HELRO
Uncharacterized protein
Search

RAD52

0.81	DNA repair protein RAD52 homolog

0.83	GO:0045002	double-strand break repair via single-strand annealing
0.83	GO:0000730	DNA recombinase assembly
0.54	GO:2000819	regulation of nucleotide-excision repair
0.54	GO:0000729	DNA double-strand break processing
0.50	GO:0051260	protein homooligomerization
0.49	GO:0034599	cellular response to oxidative stress
0.34	GO:0007015	actin filament organization

0.48	GO:0042802	identical protein binding
0.48	GO:0003697	single-stranded DNA binding
0.34	GO:0003785	actin monomer binding
0.33	GO:0005509	calcium ion binding

0.59	GO:0005634	nucleus
0.47	GO:0032993	protein-DNA complex
0.42	GO:0043234	protein complex
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part

tr|T1FY06|T1FY06_HELRO
Uncharacterized protein
Search

tr|T1FY07|T1FY07_HELRO
Eukaryotic translation initiation factor 3 subunit H
Search

EIF3H

0.71	Eukaryotic translation initiation factor 3 subunit H-B

0.71	GO:0006413	translational initiation
0.69	GO:0002181	cytoplasmic translation
0.65	GO:0022618	ribonucleoprotein complex assembly
0.41	GO:0048882	lateral line development
0.40	GO:0007420	brain development
0.40	GO:0072359	circulatory system development
0.39	GO:0006417	regulation of translation

0.72	GO:0003743	translation initiation factor activity
0.34	GO:0005515	protein binding

0.78	GO:0005852	eukaryotic translation initiation factor 3 complex
0.70	GO:0016282	eukaryotic 43S preinitiation complex
0.70	GO:0033290	eukaryotic 48S preinitiation complex
0.36	GO:0070062	extracellular exosome
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

tr|T1FY08|T1FY08_HELRO
Uncharacterized protein
Search

0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.54	GO:0051726	regulation of cell cycle
0.45	GO:0009887	animal organ morphogenesis
0.42	GO:0042023	DNA endoreduplication
0.40	GO:0051053	negative regulation of DNA metabolic process
0.40	GO:0043066	negative regulation of apoptotic process
0.38	GO:0051253	negative regulation of RNA metabolic process

0.66	GO:0046983	protein dimerization activity
0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.46	GO:0008134	transcription factor binding
0.39	GO:0001067	regulatory region nucleic acid binding
0.33	GO:0004089	carbonate dehydratase activity
0.33	GO:0004527	exonuclease activity
0.32	GO:0008270	zinc ion binding

0.75	GO:0005667	transcription factor complex
0.61	GO:0005634	nucleus
0.42	GO:0031523	Myb complex
0.42	GO:0043233	organelle lumen
0.39	GO:0000785	chromatin
0.36	GO:0005737	cytoplasm
0.33	GO:0031248	protein acetyltransferase complex
0.33	GO:0012505	endomembrane system
0.32	GO:0031967	organelle envelope
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:4.2.1.1

GO:0004089

tr|T1FY09|T1FY09_HELRO
Uncharacterized protein
Search

MANBA

0.57	Beta-D-mannosidase

0.59	GO:0005975	carbohydrate metabolic process
0.35	GO:0043312	neutrophil degranulation
0.35	GO:0006516	glycoprotein catabolic process
0.33	GO:0051276	chromosome organization
0.33	GO:0044267	cellular protein metabolic process
0.33	GO:0036211	protein modification process
0.32	GO:0043043	peptide biosynthetic process
0.32	GO:0010467	gene expression
0.32	GO:0009059	macromolecule biosynthetic process

0.65	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.36	GO:0005537	mannose binding
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.40	GO:0043231	intracellular membrane-bounded organelle
0.35	GO:0044444	cytoplasmic part
0.34	GO:0012506	vesicle membrane
0.34	GO:0005615	extracellular space
0.34	GO:0097708	intracellular vesicle
0.34	GO:0098805	whole membrane
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0012505	endomembrane system
0.33	GO:0031974	membrane-enclosed lumen
0.33	GO:0043232	intracellular non-membrane-bounded organelle

0.65

GO:0004553

tr|T1FY10|T1FY10_HELRO
Uncharacterized protein
Search

0.50	High affinity copper uptake protein 1

0.81	GO:0035434	copper ion transmembrane transport
0.50	GO:0006878	cellular copper ion homeostasis
0.49	GO:0015677	copper ion import
0.43	GO:0002027	regulation of heart rate
0.39	GO:0015680	intracellular copper ion transport
0.37	GO:0072719	cellular response to cisplatin
0.37	GO:0042539	hypotonic salinity response
0.37	GO:0071391	cellular response to estrogen stimulus
0.36	GO:0099587	inorganic ion import across plasma membrane
0.36	GO:0010038	response to metal ion

0.82	GO:0005375	copper ion transmembrane transporter activity
0.43	GO:0042802	identical protein binding
0.32	GO:0042626	ATPase activity, coupled to transmembrane movement of substances

0.45	GO:0055037	recycling endosome
0.44	GO:0005770	late endosome
0.38	GO:0000329	fungal-type vacuole membrane
0.37	GO:0005886	plasma membrane
0.36	GO:0043025	neuronal cell body
0.33	GO:0016471	vacuolar proton-transporting V-type ATPase complex
0.30	GO:0016021	integral component of membrane

tr|T1FY11|T1FY11_HELRO
Transcription initiation factor IIA subunit 2
Search

0.47	Transcription initiation factor IIA subunit 2

0.79	GO:0006367	transcription initiation from RNA polymerase II promoter
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.50	GO:0070897	DNA-templated transcriptional preinitiation complex assembly
0.47	GO:1902680	positive regulation of RNA biosynthetic process
0.47	GO:0044093	positive regulation of molecular function

0.53	GO:0001129	RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly
0.51	GO:0017025	TBP-class protein binding
0.50	GO:0003713	transcription coactivator activity

0.83

GO:0005672

transcription factor TFIIA complex

tr|T1FY12|T1FY12_HELRO
Uncharacterized protein
Search

0.85	GO:0060285	cilium-dependent cell motility
0.85	GO:0070286	axonemal dynein complex assembly
0.39	GO:0032526	response to retinoic acid
0.34	GO:0071897	DNA biosynthetic process
0.34	GO:0006260	DNA replication
0.33	GO:0006468	protein phosphorylation
0.33	GO:0000492	box C/D snoRNP assembly
0.32	GO:0006457	protein folding
0.32	GO:0006364	rRNA processing

0.35	GO:0005515	protein binding
0.35	GO:0003887	DNA-directed DNA polymerase activity
0.35	GO:0035091	phosphatidylinositol binding
0.34	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0003677	DNA binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.49	GO:0005737	cytoplasm
0.36	GO:0036064	ciliary basal body
0.33	GO:0097255	R2TP complex
0.33	GO:0005732	small nucleolar ribonucleoprotein complex

0.35

EC:2.7.7.7

GO:0003887

tr|T1FY13|T1FY13_HELRO
Uncharacterized protein
Search

tr|T1FY14|T1FY14_HELRO
Uncharacterized protein
Search

0.73	Sl allatostatin A receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.36	GO:0006468	protein phosphorylation

0.72	GO:0004930	G-protein coupled receptor activity
0.54	GO:0001653	peptide receptor activity
0.40	GO:0050254	rhodopsin kinase activity
0.35	GO:0042923	neuropeptide binding
0.35	GO:0042562	hormone binding

0.43

GO:0005887

integral component of plasma membrane

0.40

GO:0050254

tr|T1FY15|T1FY15_HELRO
Uncharacterized protein
Search

0.82	ADP ribosylation factor interacting protein 2

0.68	GO:0050708	regulation of protein secretion
0.45	GO:0006886	intracellular protein transport
0.44	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation
0.43	GO:0045887	positive regulation of synaptic growth at neuromuscular junction
0.43	GO:0048149	behavioral response to ethanol

0.77	GO:0019904	protein domain specific binding
0.71	GO:0070273	phosphatidylinositol-4-phosphate binding
0.49	GO:0045296	cadherin binding
0.43	GO:0034452	dynactin binding

0.73	GO:0032588	trans-Golgi network membrane
0.44	GO:0005829	cytosol

tr|T1FY16|T1FY16_HELRO
Uncharacterized protein
Search

CLPTM1

0.90	CLPTM1, transmembrane protein

0.75

GO:0033081

regulation of T cell differentiation in thymus

0.69	GO:0009897	external side of plasma membrane
0.48	GO:0005887	integral component of plasma membrane

tr|T1FY17|T1FY17_HELRO
Uncharacterized protein
Search

0.10	Fibropellin-1 (Fragment)

0.56	GO:0007219	Notch signaling pathway
0.50	GO:0030154	cell differentiation
0.50	GO:0007275	multicellular organism development
0.48	GO:0050793	regulation of developmental process
0.47	GO:0045967	negative regulation of growth rate
0.47	GO:2001027	negative regulation of endothelial cell chemotaxis
0.46	GO:0072602	interleukin-4 secretion
0.46	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
0.46	GO:0071372	cellular response to follicle-stimulating hormone stimulus
0.46	GO:0045955	negative regulation of calcium ion-dependent exocytosis

0.70	GO:0005509	calcium ion binding
0.46	GO:0060089	molecular transducer activity
0.46	GO:0005112	Notch binding
0.45	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.44	GO:0031490	chromatin DNA binding
0.44	GO:0001047	core promoter binding
0.42	GO:0004857	enzyme inhibitor activity
0.42	GO:0046982	protein heterodimerization activity
0.42	GO:0019899	enzyme binding
0.39	GO:0043565	sequence-specific DNA binding

0.46	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex
0.44	GO:0043235	receptor complex
0.44	GO:0016324	apical plasma membrane
0.43	GO:0005912	adherens junction
0.42	GO:0009986	cell surface
0.41	GO:0031410	cytoplasmic vesicle
0.41	GO:0005783	endoplasmic reticulum
0.39	GO:0005634	nucleus
0.35	GO:0015629	actin cytoskeleton
0.35	GO:0070013	intracellular organelle lumen

0.34

GO:0004713

tr|T1FY18|T1FY18_HELRO
Uncharacterized protein
Search

tr|T1FY19|T1FY19_HELRO
Uncharacterized protein
Search

TBCB

0.90	Tubulin-specific chaperone B

0.61	GO:0009793	embryo development ending in seed dormancy
0.52	GO:0051301	cell division
0.44	GO:0031122	cytoplasmic microtubule organization
0.42	GO:0007399	nervous system development
0.41	GO:0030154	cell differentiation
0.36	GO:0007023	post-chaperonin tubulin folding pathway
0.34	GO:0006468	protein phosphorylation

0.39	GO:0005515	protein binding
0.34	GO:0008270	zinc ion binding
0.34	GO:0004672	protein kinase activity
0.33	GO:0003676	nucleic acid binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.64	GO:0009524	phragmoplast
0.64	GO:0005829	cytosol
0.48	GO:0005634	nucleus
0.41	GO:0005874	microtubule
0.30	GO:0031224	intrinsic component of membrane

tr|T1FY20|T1FY20_HELRO
Uncharacterized protein
Search

tr|T1FY21|T1FY21_HELRO
Uncharacterized protein
Search

GRIA2

0.63	Glutamate ionotropic receptor AMPA type subunit 2

0.77	GO:0060079	excitatory postsynaptic potential
0.74	GO:0035235	ionotropic glutamate receptor signaling pathway
0.59	GO:0034220	ion transmembrane transport
0.35	GO:0006821	chloride transport
0.35	GO:0060992	response to fungicide
0.35	GO:0010226	response to lithium ion
0.35	GO:0035249	synaptic transmission, glutamatergic
0.35	GO:0001919	regulation of receptor recycling

0.79	GO:0005234	extracellularly glutamate-gated ion channel activity
0.75	GO:0004970	ionotropic glutamate receptor activity
0.46	GO:0099094	ligand-gated cation channel activity
0.37	GO:0001540	amyloid-beta binding
0.36	GO:0016934	extracellularly glycine-gated chloride channel activity
0.34	GO:0030165	PDZ domain binding

0.76	GO:0045211	postsynaptic membrane
0.72	GO:0030054	cell junction
0.48	GO:0032281	AMPA glutamate receptor complex
0.36	GO:0043197	dendritic spine
0.36	GO:0030666	endocytic vesicle membrane
0.35	GO:0098843	postsynaptic endocytic zone
0.35	GO:0106003	amyloid-beta complex
0.35	GO:0060076	excitatory synapse
0.35	GO:0043083	synaptic cleft
0.35	GO:0043198	dendritic shaft

tr|T1FY22|T1FY22_HELRO
Uncharacterized protein
Search

0.10	UPF0029-domain-containing protein (Fragment)

0.84	GO:0060733	regulation of eIF2 alpha phosphorylation by amino acid starvation
0.76	GO:0031333	negative regulation of protein complex assembly
0.75	GO:1901561	response to benomyl
0.75	GO:0071494	cellular response to UV-C
0.74	GO:1990253	cellular response to leucine starvation
0.73	GO:0071264	positive regulation of translational initiation in response to starvation
0.73	GO:0031953	negative regulation of protein autophosphorylation
0.73	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress
0.72	GO:0071468	cellular response to acidic pH
0.70	GO:0070301	cellular response to hydrogen peroxide

0.68	GO:0043022	ribosome binding
0.68	GO:0003779	actin binding
0.60	GO:0004860	protein kinase inhibitor activity
0.44	GO:0004969	histamine receptor activity
0.35	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.34	GO:0008270	zinc ion binding

0.78	GO:0005844	polysome
0.49	GO:0005840	ribosome
0.36	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1FY23|T1FY23_HELRO
Uncharacterized protein
Search

0.55	Putative YRB1-ran-specific GTPase-activating protein (Fragment)

0.69	GO:0046907	intracellular transport
0.58	GO:0000413	protein peptidyl-prolyl isomerization
0.53	GO:0006457	protein folding
0.46	GO:0046604	positive regulation of mitotic centrosome separation
0.44	GO:0006606	protein import into nucleus
0.44	GO:0000082	G1/S transition of mitotic cell cycle
0.43	GO:0007051	spindle organization
0.42	GO:0043085	positive regulation of catalytic activity
0.42	GO:0006405	RNA export from nucleus
0.42	GO:0043087	regulation of GTPase activity

0.58	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.45	GO:0046872	metal ion binding
0.45	GO:0008536	Ran GTPase binding
0.42	GO:0016874	ligase activity
0.42	GO:0005096	GTPase activator activity

0.45	GO:0005622	intracellular
0.40	GO:0005642	annulate lamellae
0.38	GO:0044422	organelle part
0.38	GO:0043227	membrane-bounded organelle
0.38	GO:0043228	non-membrane-bounded organelle
0.36	GO:0031975	envelope
0.36	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

0.58

GO:0003755

tr|T1FY24|T1FY24_HELRO
Uncharacterized protein
Search

ZNFX1

0.72	LOW QUALITY PROTEIN: NFX1-type zinc finger-containing protein 1

0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:2001141	regulation of RNA biosynthetic process
0.55	GO:0010468	regulation of gene expression

0.62	GO:0008270	zinc ion binding
0.60	GO:0003700	DNA binding transcription factor activity
0.35	GO:0030554	adenyl nucleotide binding
0.35	GO:0097367	carbohydrate derivative binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0003723	RNA binding
0.34	GO:0004386	helicase activity

0.60	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

tr|T1FY25|T1FY25_HELRO
Uncharacterized protein
Search

0.68	vacuolar protein sorting-associated protein 13B-like

0.56

GO:0015031

protein transport

0.30

GO:0016021

integral component of membrane

tr|T1FY26|T1FY26_HELRO
Uncharacterized protein
Search

0.74	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.54	GO:0030036	actin cytoskeleton organization
0.50	GO:2001045	negative regulation of integrin-mediated signaling pathway
0.50	GO:0061386	closure of optic fissure
0.48	GO:0048484	enteric nervous system development
0.48	GO:0001755	neural crest cell migration
0.47	GO:0001843	neural tube closure
0.47	GO:0007266	Rho protein signal transduction
0.43	GO:0051726	regulation of cell cycle
0.43	GO:0043085	positive regulation of catalytic activity

0.75	GO:0004864	protein phosphatase inhibitor activity
0.72	GO:0003779	actin binding
0.61	GO:0008157	protein phosphatase 1 binding
0.49	GO:0072542	protein phosphatase activator activity
0.38	GO:0005199	structural constituent of cell wall
0.34	GO:0004252	serine-type endopeptidase activity

0.47	GO:0005829	cytosol
0.46	GO:0030027	lamellipodium
0.44	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.34

GO:0004252

tr|T1FY27|T1FY27_HELRO
Peptidyl-prolyl cis-trans isomerase
Search

PPIH

0.48	Peptidyl-prolyl cis-trans isomerase H

0.72	GO:0000413	protein peptidyl-prolyl isomerization
0.68	GO:0006457	protein folding
0.50	GO:0045070	positive regulation of viral genome replication
0.36	GO:0008380	RNA splicing
0.35	GO:0006397	mRNA processing
0.34	GO:0048478	replication fork protection
0.34	GO:0042149	cellular response to glucose starvation
0.34	GO:0001525	angiogenesis
0.34	GO:0006452	translational frameshifting
0.34	GO:0000054	ribosomal subunit export from nucleus

0.72	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.45	GO:0043021	ribonucleoprotein complex binding
0.38	GO:0003924	GTPase activity
0.37	GO:0032550	purine ribonucleoside binding
0.37	GO:0019001	guanyl nucleotide binding
0.35	GO:0032555	purine ribonucleotide binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0016018	cyclosporin A binding
0.34	GO:0005515	protein binding
0.33	GO:0016887	ATPase activity

0.52	GO:0071001	U4/U6 snRNP
0.48	GO:0046540	U4/U6 x U5 tri-snRNP complex
0.48	GO:0016607	nuclear speck
0.37	GO:0005737	cytoplasm
0.36	GO:0005681	spliceosomal complex
0.34	GO:0005844	polysome
0.34	GO:0035770	ribonucleoprotein granule
0.34	GO:0031514	motile cilium
0.30	GO:0031224	intrinsic component of membrane

0.72

GO:0003755

tr|T1FY28|T1FY28_HELRO
Uncharacterized protein
Search

0.87	Calcineurin B subunit

0.50	GO:0030431	sleep
0.45	GO:0030241	skeletal muscle myosin thick filament assembly
0.45	GO:0051531	NFAT protein import into nucleus
0.44	GO:0033173	calcineurin-NFAT signaling cascade
0.44	GO:0060487	lung epithelial cell differentiation
0.44	GO:0045214	sarcomere organization
0.43	GO:0001569	branching involved in blood vessel morphogenesis
0.43	GO:0022011	myelination in peripheral nervous system
0.43	GO:0001837	epithelial to mesenchymal transition
0.42	GO:0006470	protein dephosphorylation

0.70	GO:0005509	calcium ion binding
0.41	GO:0004721	phosphoprotein phosphatase activity
0.41	GO:0016018	cyclosporin A binding
0.38	GO:0005515	protein binding
0.37	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity
0.34	GO:0003684	damaged DNA binding

0.43	GO:0042383	sarcolemma
0.42	GO:0005955	calcineurin complex
0.36	GO:0005829	cytosol
0.36	GO:0008021	synaptic vesicle
0.34	GO:0005634	nucleus
0.33	GO:0070013	intracellular organelle lumen
0.33	GO:0005739	mitochondrion
0.32	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

0.41

GO:0004721

tr|T1FY29|T1FY29_HELRO
Uncharacterized protein
Search

LOC106780518

0.35	Multidrug MFS transporter

0.40	GO:0051301	cell division
0.40	GO:0043572	plastid fission
0.39	GO:0009658	chloroplast organization

0.60	GO:0050662	coenzyme binding
0.37	GO:0042803	protein homodimerization activity
0.30	GO:0003824	catalytic activity

0.38	GO:0009941	chloroplast envelope
0.30	GO:0016020	membrane

tr|T1FY30|T1FY30_HELRO
Uncharacterized protein
Search

FSN

0.90	F-box/SPRY domain-containing protein 1

0.77	GO:0060386	synapse assembly involved in innervation
0.75	GO:0021957	corticospinal tract morphogenesis
0.74	GO:0021960	anterior commissure morphogenesis
0.74	GO:0021800	cerebral cortex tangential migration
0.72	GO:0021799	cerebral cortex radially oriented cell migration
0.71	GO:0016567	protein ubiquitination
0.69	GO:0001764	neuron migration
0.66	GO:0045886	negative regulation of synaptic growth at neuromuscular junction
0.65	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.64	GO:0007274	neuromuscular synaptic transmission

0.39	GO:0005515	protein binding
0.38	GO:0003735	structural constituent of ribosome
0.37	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.37	GO:0004842	ubiquitin-protein transferase activity
0.37	GO:0001882	nucleoside binding
0.35	GO:0003677	DNA binding

0.73	GO:0045202	synapse
0.63	GO:0097458	neuron part
0.61	GO:0019005	SCF ubiquitin ligase complex
0.61	GO:0045495	pole plasm
0.58	GO:0030054	cell junction
0.55	GO:0005938	cell cortex
0.51	GO:0043226	organelle
0.42	GO:0098590	plasma membrane region
0.38	GO:0044297	cell body
0.37	GO:0030529	intracellular ribonucleoprotein complex

0.37	EC:2.7.7.6	GO:0003899
0.37	KEGG:R03876	GO:0004842

tr|T1FY31|T1FY31_HELRO
Uncharacterized protein
Search

ADPRH

0.96	ADP-ribosylarginine hydrolase

0.84	GO:0051725	protein de-ADP-ribosylation
0.50	GO:0031338	regulation of vesicle fusion
0.50	GO:0090630	activation of GTPase activity
0.44	GO:0006886	intracellular protein transport
0.35	GO:0006629	lipid metabolic process

0.84	GO:0003875	ADP-ribosylarginine hydrolase activity
0.60	GO:0000287	magnesium ion binding
0.48	GO:0017137	Rab GTPase binding
0.48	GO:0030955	potassium ion binding
0.47	GO:0005096	GTPase activator activity
0.36	GO:0052689	carboxylic ester hydrolase activity

0.44	GO:0012505	endomembrane system
0.36	GO:0005622	intracellular
0.35	GO:0005576	extracellular region
0.30	GO:0016020	membrane

0.84	EC:3.2.2.19	GO:0003875
0.36	KEGG:R00630	GO:0052689

tr|T1FY32|T1FY32_HELRO
Uncharacterized protein
Search

0.27	Short-chain dehydrogenase

0.48	GO:0055114	oxidation-reduction process
0.34	GO:0019433	triglyceride catabolic process
0.33	GO:0006654	phosphatidic acid biosynthetic process
0.32	GO:0006633	fatty acid biosynthetic process

0.49	GO:0016491	oxidoreductase activity
0.35	GO:0004312	fatty acid synthase activity
0.34	GO:0003723	RNA binding
0.33	GO:0004806	triglyceride lipase activity
0.32	GO:0051287	NAD binding

0.33	GO:0012505	endomembrane system
0.33	GO:0005811	lipid droplet
0.32	GO:0043231	intracellular membrane-bounded organelle
0.32	GO:0044444	cytoplasmic part
0.32	GO:0005618	cell wall
0.31	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.49

GO:0016491

tr|T1FY33|T1FY33_HELRO
Uncharacterized protein
Search

0.31	Transitional endoplasmic reticulum ATPase

0.44	GO:0051013	microtubule severing
0.43	GO:0051301	cell division
0.38	GO:0030163	protein catabolic process
0.38	GO:0016320	endoplasmic reticulum membrane fusion
0.37	GO:0043632	modification-dependent macromolecule catabolic process
0.37	GO:0006508	proteolysis
0.36	GO:0032270	positive regulation of cellular protein metabolic process
0.36	GO:0007029	endoplasmic reticulum organization
0.36	GO:0016236	macroautophagy
0.36	GO:0045732	positive regulation of protein catabolic process

0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.48	GO:0016787	hydrolase activity
0.38	GO:0140096	catalytic activity, acting on a protein
0.35	GO:0043130	ubiquitin binding
0.34	GO:0019888	protein phosphatase regulator activity
0.34	GO:0060090	molecular adaptor activity
0.34	GO:0042802	identical protein binding

0.37	GO:1905369	endopeptidase complex
0.36	GO:0043234	protein complex
0.36	GO:0012505	endomembrane system
0.35	GO:0044754	autolysosome
0.35	GO:0045169	fusome
0.35	GO:0043186	P granule
0.35	GO:0044428	nuclear part
0.35	GO:1990023	mitotic spindle midzone
0.35	GO:0000153	cytoplasmic ubiquitin ligase complex
0.35	GO:0098805	whole membrane

0.48

GO:0016787

tr|T1FY34|T1FY34_HELRO
Uncharacterized protein
Search

ANKRD49

0.71	ankyrin repeat domain-containing protein 49

0.47	GO:0009083	branched-chain amino acid catabolic process
0.46	GO:0045893	positive regulation of transcription, DNA-templated
0.44	GO:0016310	phosphorylation
0.38	GO:0055114	oxidation-reduction process
0.38	GO:0007283	spermatogenesis
0.37	GO:0036211	protein modification process
0.37	GO:0032502	developmental process
0.36	GO:0044267	cellular protein metabolic process
0.36	GO:0007165	signal transduction
0.35	GO:0051092	positive regulation of NF-kappaB transcription factor activity

0.48	GO:0003826	alpha-ketoacid dehydrogenase activity
0.48	GO:0003863	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
0.45	GO:0016301	kinase activity
0.37	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.37	GO:0140096	catalytic activity, acting on a protein
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0016409	palmitoyltransferase activity
0.34	GO:0016417	S-acyltransferase activity

0.36	GO:0005634	nucleus
0.35	GO:0005829	cytosol
0.35	GO:0008305	integrin complex
0.33	GO:0043034	costamere
0.33	GO:0000151	ubiquitin ligase complex
0.32	GO:0044446	intracellular organelle part

0.48

EC:1.2.4.4

GO:0003863

tr|T1FY35|T1FY35_HELRO
Uncharacterized protein
Search

ADPRH

0.96	ADP-ribosylarginine hydrolase

0.81	GO:0051725	protein de-ADP-ribosylation
0.48	GO:0031338	regulation of vesicle fusion
0.48	GO:0090630	activation of GTPase activity
0.43	GO:0006886	intracellular protein transport
0.33	GO:0006629	lipid metabolic process

0.81	GO:0003875	ADP-ribosylarginine hydrolase activity
0.59	GO:0000287	magnesium ion binding
0.53	GO:0030955	potassium ion binding
0.46	GO:0017137	Rab GTPase binding
0.45	GO:0005096	GTPase activator activity
0.34	GO:0052689	carboxylic ester hydrolase activity

0.42	GO:0012505	endomembrane system
0.35	GO:0005622	intracellular
0.34	GO:0005576	extracellular region
0.30	GO:0016020	membrane

0.81	EC:3.2.2.19	GO:0003875
0.34	KEGG:R00630	GO:0052689

tr|T1FY36|T1FY36_HELRO
Uncharacterized protein
Search

TRAPPC9

0.68	Trafficking protein particle complex subunit 9

0.78	GO:0021987	cerebral cortex development
0.75	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.69	GO:0030182	neuron differentiation
0.40	GO:0048208	COPII vesicle coating
0.39	GO:0000002	mitochondrial genome maintenance
0.38	GO:0000723	telomere maintenance
0.37	GO:0032392	DNA geometric change
0.36	GO:0006310	DNA recombination
0.36	GO:0006281	DNA repair
0.35	GO:0055085	transmembrane transport

0.41	GO:0005515	protein binding
0.39	GO:0043141	ATP-dependent 5'-3' DNA helicase activity
0.37	GO:0098772	molecular function regulator
0.35	GO:0004252	serine-type endopeptidase activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0003677	DNA binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.75	GO:0030008	TRAPP complex
0.60	GO:0005802	trans-Golgi network
0.44	GO:0005783	endoplasmic reticulum
0.42	GO:0005770	late endosome
0.42	GO:0005769	early endosome
0.38	GO:0000139	Golgi membrane
0.37	GO:0005829	cytosol
0.35	GO:0005634	nucleus
0.35	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.39

EC:3.6.1

GO:0043141

tr|T1FY37|T1FY37_HELRO
Gluconokinase
Search

IDNK

0.49	Gluconokinase

0.59	GO:0005975	carbohydrate metabolic process
0.57	GO:0016310	phosphorylation
0.51	GO:0072329	monocarboxylic acid catabolic process

0.80	GO:0046316	gluconokinase activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0032553	ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0016787	hydrolase activity

0.30

GO:0031224

intrinsic component of membrane

0.80	EC:2.7.1.12	GO:0046316
0.80	KEGG:R01737	GO:0046316

tr|T1FY38|T1FY38_HELRO
Uncharacterized protein
Search

tr|T1FY39|T1FY39_HELRO
Polypeptide N-acetylgalactosaminyltransferase
Search

0.54	Polypeptide N-acetylgalactosaminyltransferase

0.73	GO:0006486	protein glycosylation
0.40	GO:0018210	peptidyl-threonine modification
0.38	GO:0032504	multicellular organism reproduction
0.35	GO:0002378	immunoglobulin biosynthetic process
0.34	GO:0018209	peptidyl-serine modification

0.69	GO:0030246	carbohydrate binding
0.64	GO:0016757	transferase activity, transferring glycosyl groups
0.38	GO:0005112	Notch binding
0.36	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0046872	metal ion binding

0.72	GO:0000139	Golgi membrane
0.38	GO:0005795	Golgi stack
0.34	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.64

GO:0016757

tr|T1FY40|T1FY40_HELRO
Uncharacterized protein
Search

0.72	Eukaryotic translation initiation factor 2c

0.79	GO:0031047	gene silencing by RNA
0.42	GO:0090328	regulation of olfactory learning
0.41	GO:0098795	mRNA cleavage involved in gene silencing
0.41	GO:0006413	translational initiation
0.41	GO:0046959	habituation
0.41	GO:0030727	germarium-derived female germ-line cyst formation
0.41	GO:0007294	germarium-derived oocyte fate determination
0.41	GO:0036099	female germ-line stem cell population maintenance
0.41	GO:0007367	segment polarity determination
0.40	GO:0016441	posttranscriptional gene silencing

0.51	GO:0003676	nucleic acid binding
0.38	GO:0019899	enzyme binding
0.33	GO:0004576	oligosaccharyl transferase activity

0.39	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0005634	nucleus
0.36	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0016020	membrane

0.33

GO:0004576

tr|T1FY41|T1FY41_HELRO
Uncharacterized protein
Search

0.79	GO:0045010	actin nucleation
0.50	GO:0072092	ureteric bud invasion
0.48	GO:0051894	positive regulation of focal adhesion assembly
0.48	GO:0035137	hindlimb morphogenesis
0.48	GO:0035136	forelimb morphogenesis
0.47	GO:0051127	positive regulation of actin nucleation
0.47	GO:0048813	dendrite morphogenesis
0.46	GO:0048705	skeletal system morphogenesis
0.41	GO:0007316	pole plasm RNA localization
0.37	GO:0051758	homologous chromosome movement towards spindle pole involved in homologous chromosome segregation

0.74	GO:0008017	microtubule binding
0.45	GO:0017124	SH3 domain binding
0.37	GO:0003779	actin binding
0.32	GO:0017048	Rho GTPase binding

0.82	GO:0005884	actin filament
0.43	GO:0015630	microtubule cytoskeleton
0.40	GO:0005634	nucleus
0.40	GO:0005938	cell cortex
0.36	GO:0005902	microvillus
0.36	GO:0030659	cytoplasmic vesicle membrane
0.35	GO:0005829	cytosol
0.35	GO:0005912	adherens junction
0.35	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0070013	intracellular organelle lumen

tr|T1FY42|T1FY42_HELRO
Uncharacterized protein
Search

FBXL14

0.86	F-box and leucine-rich repeat protein 14

0.68	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.42	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
0.38	GO:0000209	protein polyubiquitination
0.38	GO:0043687	post-translational protein modification

0.65	GO:0004842	ubiquitin-protein transferase activity
0.35	GO:0005515	protein binding

0.65	GO:0019005	SCF ubiquitin ligase complex
0.44	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.65

GO:0004842

tr|T1FY43|T1FY43_HELRO
Polypeptide N-acetylgalactosaminyltransferase
Search

GALNT2

0.65	Polypeptide N-acetylgalactosaminyltransferase

0.72	GO:0006486	protein glycosylation
0.57	GO:0002378	immunoglobulin biosynthetic process
0.52	GO:0018210	peptidyl-threonine modification
0.51	GO:0018209	peptidyl-serine modification

0.68	GO:0030246	carbohydrate binding
0.64	GO:0016757	transferase activity, transferring glycosyl groups
0.47	GO:0030145	manganese ion binding
0.42	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0005515	protein binding

0.72	GO:0000139	Golgi membrane
0.50	GO:0005795	Golgi stack
0.50	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0005615	extracellular space
0.36	GO:1903561	extracellular vesicle
0.35	GO:0005796	Golgi lumen
0.34	GO:0031301	integral component of organelle membrane
0.34	GO:0005789	endoplasmic reticulum membrane

0.64

GO:0016757

tr|T1FY44|T1FY44_HELRO
Uncharacterized protein
Search

0.44	calcineurin B homologous protein 1-like

0.70

GO:0005509

calcium ion binding

tr|T1FY45|T1FY45_HELRO
Methionine aminopeptidase 2
Search

METAP2

0.63	Methionine aminopeptidase 2

0.70	GO:0070084	protein initiator methionine removal
0.61	GO:0006508	proteolysis
0.55	GO:0018206	peptidyl-methionine modification
0.51	GO:0031365	N-terminal protein amino acid modification
0.48	GO:0051604	protein maturation
0.35	GO:0022400	regulation of rhodopsin mediated signaling pathway
0.34	GO:0045766	positive regulation of angiogenesis
0.34	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.34	GO:0043066	negative regulation of apoptotic process
0.32	GO:0006351	transcription, DNA-templated

0.74	GO:0008235	metalloexopeptidase activity
0.71	GO:0004177	aminopeptidase activity
0.54	GO:0046872	metal ion binding
0.33	GO:0003723	RNA binding
0.33	GO:0005515	protein binding
0.33	GO:0003700	DNA binding transcription factor activity
0.32	GO:0003677	DNA binding

0.47	GO:0005829	cytosol
0.41	GO:0005886	plasma membrane
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.71

EC:3.4.11

GO:0004177

tr|T1FY46|T1FY46_HELRO
Uncharacterized protein
Search

tr|T1FY47|T1FY47_HELRO
Uncharacterized protein
Search

0.10	Organic anion transporter, putative (Fragment)

0.54	GO:0055085	transmembrane transport
0.54	GO:0006811	ion transport
0.40	GO:0071702	organic substance transport
0.36	GO:0010876	lipid localization
0.36	GO:0007588	excretion
0.36	GO:1901998	toxin transport
0.35	GO:0070327	thyroid hormone transport
0.34	GO:0042886	amide transport

0.56

GO:0005215

transporter activity

0.51	GO:0005886	plasma membrane
0.33	GO:0043229	intracellular organelle
0.30	GO:0016021	integral component of membrane

tr|T1FY48|T1FY48_HELRO
Uncharacterized protein
Search

YME1

0.86	ATP-dependent Zinc metalloprotease YME1

0.61	GO:0006508	proteolysis
0.37	GO:0051301	cell division
0.34	GO:0051013	microtubule severing

0.70	GO:0004222	metalloendopeptidase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0008568	microtubule-severing ATPase activity
0.33	GO:0046872	metal ion binding
0.32	GO:0003677	DNA binding

0.39	GO:0005739	mitochondrion
0.33	GO:0005634	nucleus
0.33	GO:0019866	organelle inner membrane
0.30	GO:0031224	intrinsic component of membrane

0.70

GO:0004222

tr|T1FY49|T1FY49_HELRO
Uncharacterized protein
Search

0.37	Pkinase-domain-containing protein

0.63	GO:0006468	protein phosphorylation
0.50	GO:0010868	negative regulation of triglyceride biosynthetic process
0.49	GO:0032792	negative regulation of CREB transcription factor activity
0.48	GO:0043276	anoikis
0.48	GO:0043153	entrainment of circadian clock by photoperiod
0.47	GO:0010830	regulation of myotube differentiation
0.47	GO:0045721	negative regulation of gluconeogenesis
0.47	GO:0055007	cardiac muscle cell differentiation
0.44	GO:0035556	intracellular signal transduction
0.44	GO:0007346	regulation of mitotic cell cycle

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0008140	cAMP response element binding protein binding
0.46	GO:0042826	histone deacetylase binding
0.45	GO:0019901	protein kinase binding
0.45	GO:0000287	magnesium ion binding
0.38	GO:0071889	14-3-3 protein binding
0.34	GO:0018024	histone-lysine N-methyltransferase activity

0.42	GO:0005634	nucleus
0.37	GO:0005737	cytoplasm
0.36	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part
0.33	GO:0005694	chromosome
0.33	GO:0005576	extracellular region
0.30	GO:0016020	membrane

0.34

GO:0018024

tr|T1FY50|T1FY50_HELRO
Uncharacterized protein
Search

0.50	DNA-directed RNA polymerase II subunit E

0.58	GO:0006351	transcription, DNA-templated
0.38	GO:0001172	transcription, RNA-templated
0.37	GO:0006399	tRNA metabolic process
0.33	GO:0032049	cardiolipin biosynthetic process
0.33	GO:0001510	RNA methylation
0.32	GO:0034470	ncRNA processing

0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.55	GO:0003677	DNA binding
0.38	GO:0003968	RNA-directed 5'-3' RNA polymerase activity
0.34	GO:0016428	tRNA (cytosine-5-)-methyltransferase activity
0.33	GO:0004605	phosphatidate cytidylyltransferase activity
0.32	GO:0003723	RNA binding

0.61	GO:0005634	nucleus
0.41	GO:0000428	DNA-directed RNA polymerase complex
0.39	GO:0031974	membrane-enclosed lumen
0.37	GO:0043232	intracellular non-membrane-bounded organelle
0.37	GO:0044446	intracellular organelle part

0.70

EC:2.7.7.6

GO:0003899

tr|T1FY51|T1FY51_HELRO
Uncharacterized protein
Search

0.37	Glutamine oxoglutarate aminotransferase

0.77	GO:0006537	glutamate biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.40	GO:0019676	ammonia assimilation cycle
0.40	GO:0097354	prenylation
0.38	GO:0006397	mRNA processing
0.36	GO:0036211	protein modification process
0.35	GO:0044267	cellular protein metabolic process

0.80	GO:0016040	glutamate synthase (NADH) activity
0.65	GO:0010181	FMN binding
0.64	GO:0051536	iron-sulfur cluster binding
0.62	GO:0050660	flavin adenine dinucleotide binding
0.59	GO:0005506	iron ion binding
0.40	GO:0008318	protein prenyltransferase activity
0.34	GO:0004355	glutamate synthase (NADPH) activity
0.33	GO:0008483	transaminase activity

0.36	GO:0005634	nucleus
0.33	GO:0005737	cytoplasm

0.80	EC:1.4.1.14	GO:0016040
0.80	KEGG:R00093	GO:0016040

tr|T1FY52|T1FY52_HELRO
Uncharacterized protein
Search

EFHC1

0.96	EF-hand domain-containing protein 1

0.61	GO:0021795	cerebral cortex cell migration
0.59	GO:0007052	mitotic spindle organization
0.58	GO:0000281	mitotic cytokinesis
0.56	GO:0051302	regulation of cell division
0.34	GO:1990830	cellular response to leukemia inhibitory factor

0.69	GO:0005509	calcium ion binding
0.61	GO:0043014	alpha-tubulin binding
0.40	GO:0008022	protein C-terminus binding

0.58	GO:0072686	mitotic spindle
0.57	GO:0000922	spindle pole
0.56	GO:0005813	centrosome
0.39	GO:0005930	axoneme
0.39	GO:0043025	neuronal cell body
0.30	GO:0031224	intrinsic component of membrane

tr|T1FY53|T1FY53_HELRO
Uncharacterized protein
Search

0.60	GO:0036211	protein modification process
0.56	GO:0070781	response to biotin
0.56	GO:0044267	cellular protein metabolic process
0.50	GO:0008283	cell proliferation
0.48	GO:0016569	covalent chromatin modification
0.34	GO:0006768	biotin metabolic process

0.79	GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity
0.57	GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
0.52	GO:0009374	biotin binding
0.47	GO:0019899	enzyme binding
0.37	GO:0004078	biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
0.37	GO:0004079	biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
0.36	GO:0071734	biotin-[pyruvate-carboxylase] ligase activity
0.36	GO:0042803	protein homodimerization activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding

0.54	GO:0005652	nuclear lamina
0.52	GO:0016363	nuclear matrix
0.47	GO:0000785	chromatin
0.46	GO:0005829	cytosol
0.42	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:6.3.4.15

GO:0004077

tr|T1FY54|T1FY54_HELRO
Gamma-tubulin complex component
Search

TUBGCP3

0.64	Gamma-tubulin complex component

0.81	GO:0007020	microtubule nucleation
0.49	GO:0090307	mitotic spindle assembly
0.49	GO:0051298	centrosome duplication
0.49	GO:0031122	cytoplasmic microtubule organization
0.47	GO:0051321	meiotic cell cycle
0.34	GO:0007338	single fertilization

0.81	GO:0043015	gamma-tubulin binding
0.50	GO:0051011	microtubule minus-end binding
0.46	GO:0005200	structural constituent of cytoskeleton

0.79	GO:0000922	spindle pole
0.75	GO:0005815	microtubule organizing center
0.73	GO:0005874	microtubule
0.48	GO:0005737	cytoplasm
0.48	GO:0032155	cell division site part
0.40	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1FY55|T1FY55_HELRO
Uncharacterized protein
Search

0.44	S-adenosyl-L-methionine-dependent methyltransferase (Fragment)

0.75	GO:0009452	7-methylguanosine RNA capping
0.69	GO:0001510	RNA methylation
0.36	GO:0071167	ribonucleoprotein complex import into nucleus
0.35	GO:0006508	proteolysis
0.34	GO:0000387	spliceosomal snRNP assembly
0.34	GO:0019216	regulation of lipid metabolic process
0.34	GO:0006351	transcription, DNA-templated
0.34	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression

0.63	GO:0008168	methyltransferase activity
0.45	GO:0140098	catalytic activity, acting on RNA
0.35	GO:0008233	peptidase activity
0.33	GO:0005515	protein binding

0.46	GO:0005829	cytosol
0.45	GO:0005634	nucleus
0.35	GO:0031974	membrane-enclosed lumen
0.35	GO:0005615	extracellular space
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.34	GO:0120114	Sm-like protein family complex
0.34	GO:0044446	intracellular organelle part
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0016020	membrane

0.63

GO:0008168

tr|T1FY56|T1FY56_HELRO
Uncharacterized protein
Search

TTBK2

0.54	Mitogen-activated protein kinase 3

0.63	GO:0006468	protein phosphorylation
0.50	GO:0061890	positive regulation of astrocyte activation
0.49	GO:1903980	positive regulation of microglial cell activation
0.48	GO:0018209	peptidyl-serine modification
0.47	GO:0032091	negative regulation of protein binding
0.47	GO:1904031	positive regulation of cyclin-dependent protein kinase activity
0.47	GO:2001056	positive regulation of cysteine-type endopeptidase activity
0.47	GO:0018210	peptidyl-threonine modification
0.46	GO:0007611	learning or memory
0.45	GO:0032273	positive regulation of protein polymerization

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding

0.49	GO:0045298	tubulin complex
0.45	GO:0048471	perinuclear region of cytoplasm
0.42	GO:0005654	nucleoplasm
0.42	GO:0005829	cytosol

tr|T1FY57|T1FY57_HELRO
Uncharacterized protein
Search

SRPK3

0.66	SRSF protein kinase 3

0.63	GO:0006468	protein phosphorylation
0.40	GO:0000245	spliceosomal complex assembly
0.39	GO:0050684	regulation of mRNA processing
0.37	GO:0035556	intracellular signal transduction

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.36	GO:0005634	nucleus
0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1FY58|T1FY58_HELRO
Uncharacterized protein
Search

0.85	Suppressor of cytokine signaling (Fragment)

0.78	GO:0040008	regulation of growth
0.72	GO:0016567	protein ubiquitination
0.62	GO:0035556	intracellular signal transduction
0.51	GO:0046426	negative regulation of JAK-STAT cascade
0.48	GO:0050868	negative regulation of T cell activation
0.48	GO:0010498	proteasomal protein catabolic process
0.45	GO:0006469	negative regulation of protein kinase activity
0.45	GO:0019221	cytokine-mediated signaling pathway
0.38	GO:0051128	regulation of cellular component organization
0.36	GO:0001678	cellular glucose homeostasis

0.46	GO:0004860	protein kinase inhibitor activity
0.44	GO:0008269	JAK pathway signal transduction adaptor activity
0.44	GO:0005159	insulin-like growth factor receptor binding

0.52	GO:0001772	immunological synapse
0.45	GO:0005622	intracellular

tr|T1FY59|T1FY59_HELRO
Uncharacterized protein
Search

tr|T1FY60|T1FY60_HELRO
Uncharacterized protein
Search

0.30

GO:0044425

membrane part

tr|T1FY61|T1FY61_HELRO
Uncharacterized protein
Search

0.92	Adrenal 4-binding protein/steroidogenic factor 1 (Fragment)

0.76	GO:0043401	steroid hormone mediated signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.43	GO:1902680	positive regulation of RNA biosynthetic process
0.42	GO:0030522	intracellular receptor signaling pathway
0.42	GO:0009888	tissue development
0.40	GO:0007420	brain development
0.40	GO:0031016	pancreas development

0.74	GO:0003707	steroid hormone receptor activity
0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.41	GO:0044212	transcription regulatory region DNA binding
0.40	GO:0003690	double-stranded DNA binding
0.40	GO:0003682	chromatin binding
0.38	GO:0070016	armadillo repeat domain binding
0.36	GO:0046982	protein heterodimerization activity
0.35	GO:0008134	transcription factor binding

0.61	GO:0005634	nucleus
0.40	GO:0005667	transcription factor complex
0.36	GO:0044446	intracellular organelle part
0.34	GO:0005783	endoplasmic reticulum
0.30	GO:0031224	intrinsic component of membrane

tr|T1FY62|T1FY62_HELRO
Uncharacterized protein
Search

AFG1L

0.67	Lactation elevated protein 1

0.52	GO:0035694	mitochondrial protein catabolic process
0.51	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen
0.34	GO:0003341	cilium movement
0.34	GO:0009264	deoxyribonucleotide catabolic process
0.32	GO:0051301	cell division

0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0004139	deoxyribose-phosphate aldolase activity
0.34	GO:0042302	structural constituent of cuticle
0.33	GO:0003924	GTPase activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0032561	guanyl ribonucleotide binding
0.33	GO:0005515	protein binding

0.42	GO:0031966	mitochondrial membrane
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.34	EC:4.1.2.4	GO:0004139
0.34	KEGG:R01066	GO:0004139

tr|T1FY63|T1FY63_HELRO
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Search

0.48	Histone-lysine N-methyltransferase, H3 lysine-79 specific

0.85	GO:0034729	histone H3-K79 methylation
0.73	GO:0051726	regulation of cell cycle
0.57	GO:0006342	chromatin silencing
0.48	GO:2000677	regulation of transcription regulatory region DNA binding
0.43	GO:0046425	regulation of JAK-STAT cascade
0.42	GO:0008284	positive regulation of cell proliferation
0.41	GO:0045944	positive regulation of transcription by RNA polymerase II
0.38	GO:0006281	DNA repair
0.37	GO:0060729	intestinal epithelial structure maintenance
0.36	GO:0060070	canonical Wnt signaling pathway

0.85	GO:0031151	histone methyltransferase activity (H3-K79 specific)
0.35	GO:0004222	metalloendopeptidase activity
0.34	GO:0008134	transcription factor binding
0.33	GO:0046872	metal ion binding
0.33	GO:0008080	N-acetyltransferase activity
0.32	GO:0003677	DNA binding

0.61	GO:0005634	nucleus
0.41	GO:0000781	chromosome, telomeric region
0.40	GO:0031974	membrane-enclosed lumen
0.37	GO:0043234	protein complex
0.34	GO:0034708	methyltransferase complex
0.30	GO:0016020	membrane

0.35

GO:0004222

tr|T1FY64|T1FY64_HELRO
Uncharacterized protein
Search

0.39	GO:0007219	Notch signaling pathway
0.38	GO:0006289	nucleotide-excision repair
0.38	GO:0051726	regulation of cell cycle
0.38	GO:0030154	cell differentiation
0.37	GO:0032392	DNA geometric change
0.37	GO:0016192	vesicle-mediated transport
0.37	GO:0050793	regulation of developmental process
0.36	GO:0006468	protein phosphorylation
0.36	GO:0006508	proteolysis

0.46	GO:0005509	calcium ion binding
0.40	GO:0004693	cyclin-dependent protein serine/threonine kinase activity
0.39	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.38	GO:0004003	ATP-dependent DNA helicase activity
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0003677	DNA binding

0.38	GO:0005634	nucleus
0.37	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.40

EC:2.7.11.22

GO:0004693

tr|T1FY65|T1FY65_HELRO
Uncharacterized protein
Search

0.50	GO:0007416	synapse assembly
0.44	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.43	GO:0010468	regulation of gene expression
0.43	GO:2001141	regulation of RNA biosynthetic process
0.42	GO:0007018	microtubule-based movement
0.40	GO:0048015	phosphatidylinositol-mediated signaling
0.40	GO:0046854	phosphatidylinositol phosphorylation
0.37	GO:0016569	covalent chromatin modification
0.37	GO:0016070	RNA metabolic process
0.37	GO:0036211	protein modification process

0.45	GO:0003700	DNA binding transcription factor activity
0.43	GO:0003777	microtubule motor activity
0.37	GO:0003676	nucleic acid binding
0.37	GO:0005515	protein binding
0.37	GO:0016301	kinase activity
0.37	GO:0008270	zinc ion binding
0.36	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.36	GO:0140096	catalytic activity, acting on a protein
0.36	GO:0030554	adenyl nucleotide binding
0.36	GO:0097367	carbohydrate derivative binding

0.49	GO:0048786	presynaptic active zone
0.45	GO:0048188	Set1C/COMPASS complex
0.39	GO:0030286	dynein complex
0.36	GO:0061695	transferase complex, transferring phosphorus-containing groups
0.35	GO:0034066	RIC1-RGP1 guanyl-nucleotide exchange factor complex
0.35	GO:0008023	transcription elongation factor complex
0.35	GO:0030015	CCR4-NOT core complex
0.35	GO:0098588	bounding membrane of organelle
0.35	GO:0000932	P-body
0.35	GO:0005829	cytosol

0.36

GO:0016773

tr|T1FY66|T1FY66_HELRO
Uncharacterized protein
Search

tr|T1FY67|T1FY67_HELRO
Uncharacterized protein
Search

0.38	Vesicle-associated membrane protein-associated protein A

0.69	GO:0030968	endoplasmic reticulum unfolded protein response
0.66	GO:0006874	cellular calcium ion homeostasis
0.55	GO:0045070	positive regulation of viral genome replication
0.55	GO:0032075	positive regulation of nuclease activity
0.52	GO:0007029	endoplasmic reticulum organization
0.52	GO:0090114	COPII-coated vesicle budding
0.50	GO:0045860	positive regulation of protein kinase activity
0.47	GO:0070972	protein localization to endoplasmic reticulum
0.46	GO:0019048	modulation by virus of host morphology or physiology
0.42	GO:0072553	terminal button organization

0.64	GO:0033149	FFAT motif binding
0.53	GO:0048487	beta-tubulin binding
0.52	GO:0045296	cadherin binding
0.49	GO:0042803	protein homodimerization activity
0.49	GO:0046982	protein heterodimerization activity
0.49	GO:0008017	microtubule binding
0.48	GO:0019899	enzyme binding

0.72	GO:0005789	endoplasmic reticulum membrane
0.60	GO:0005794	Golgi apparatus
0.47	GO:0098588	bounding membrane of organelle
0.40	GO:0043005	neuron projection
0.39	GO:0005615	extracellular space
0.36	GO:0070971	endoplasmic reticulum exit site
0.36	GO:0045202	synapse
0.35	GO:0005886	plasma membrane
0.35	GO:0070382	exocytic vesicle
0.34	GO:0030054	cell junction

tr|T1FY68|T1FY68_HELRO
Uncharacterized protein
Search

tr|T1FY69|T1FY69_HELRO
Phosphoinositide phospholipase C
Search

PLCL1

0.52	Phosphoinositide phospholipase C

0.83	GO:0032228	regulation of synaptic transmission, GABAergic
0.72	GO:0016042	lipid catabolic process
0.63	GO:0035556	intracellular signal transduction
0.54	GO:1900122	positive regulation of receptor binding
0.52	GO:0007214	gamma-aminobutyric acid signaling pathway
0.51	GO:0033135	regulation of peptidyl-serine phosphorylation
0.45	GO:0002337	B-1a B cell differentiation
0.45	GO:0050859	negative regulation of B cell receptor signaling pathway
0.45	GO:0002322	B cell proliferation involved in immune response
0.44	GO:0007340	acrosome reaction

0.84	GO:0050811	GABA receptor binding
0.82	GO:0070679	inositol 1,4,5 trisphosphate binding
0.82	GO:0004435	phosphatidylinositol phospholipase C activity
0.64	GO:0004871	signal transducer activity
0.47	GO:0005509	calcium ion binding
0.33	GO:0032794	GTPase activating protein binding
0.33	GO:0070300	phosphatidic acid binding
0.33	GO:0001786	phosphatidylserine binding
0.33	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding

0.45	GO:0005622	intracellular
0.38	GO:0005886	plasma membrane
0.32	GO:0012505	endomembrane system
0.31	GO:0031090	organelle membrane
0.31	GO:0031975	envelope
0.30	GO:0031224	intrinsic component of membrane

0.82	EC:3.1.4.11	GO:0004435
0.82	KEGG:R03435	GO:0004435

tr|T1FY70|T1FY70_HELRO
Uncharacterized protein
Search

0.11	Putative carbonic anhydrase ixodes scapularis carbonic anhydrase

0.71	GO:0006730	one-carbon metabolic process
0.51	GO:0036269	swimming behavior
0.49	GO:0021549	cerebellum development
0.47	GO:0043009	chordate embryonic development

0.77	GO:0004089	carbonate dehydratase activity
0.62	GO:0008270	zinc ion binding

0.41	GO:0031225	anchored component of membrane
0.36	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.77

EC:4.2.1.1

GO:0004089

tr|T1FY71|T1FY71_HELRO
Uncharacterized protein
Search

0.51	GO:0007155	cell adhesion
0.44	GO:0006468	protein phosphorylation
0.43	GO:0034769	basement membrane disassembly
0.43	GO:0032501	multicellular organismal process
0.42	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.42	GO:0000904	cell morphogenesis involved in differentiation
0.42	GO:0120036	plasma membrane bounded cell projection organization
0.41	GO:0030335	positive regulation of cell migration
0.40	GO:0035023	regulation of Rho protein signal transduction
0.38	GO:0048010	vascular endothelial growth factor receptor signaling pathway

0.47	GO:0005509	calcium ion binding
0.45	GO:0004672	protein kinase activity
0.41	GO:0030554	adenyl nucleotide binding
0.41	GO:0005201	extracellular matrix structural constituent
0.41	GO:0097367	carbohydrate derivative binding
0.41	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0008144	drug binding
0.40	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.36	GO:0004055	argininosuccinate synthase activity
0.36	GO:0004888	transmembrane signaling receptor activity

0.51	GO:0005604	basement membrane
0.44	GO:0030054	cell junction
0.43	GO:0005938	cell cortex
0.40	GO:0005615	extracellular space
0.37	GO:0036062	presynaptic periactive zone
0.37	GO:0097482	muscle cell postsynaptic specialization
0.37	GO:0061174	type I terminal bouton
0.36	GO:0048786	presynaptic active zone
0.36	GO:0031225	anchored component of membrane
0.36	GO:0045211	postsynaptic membrane

0.36

EC:6.3.4.5

GO:0004055

tr|T1FY72|T1FY72_HELRO
Uncharacterized protein
Search

0.79	GO:0043401	steroid hormone mediated signaling pathway
0.62	GO:0061113	pancreas morphogenesis
0.60	GO:0008206	bile acid metabolic process
0.59	GO:0045070	positive regulation of viral genome replication
0.58	GO:0042632	cholesterol homeostasis
0.58	GO:1990830	cellular response to leukemia inhibitory factor
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:0010468	regulation of gene expression

0.80	GO:0003707	steroid hormone receptor activity
0.63	GO:0043565	sequence-specific DNA binding
0.61	GO:0008270	zinc ion binding
0.60	GO:0003700	DNA binding transcription factor activity
0.58	GO:0035326	enhancer binding
0.56	GO:0003682	chromatin binding
0.55	GO:0001012	RNA polymerase II regulatory region DNA binding
0.52	GO:0005543	phospholipid binding
0.52	GO:0003690	double-stranded DNA binding
0.35	GO:0044877	macromolecular complex binding

0.61	GO:0005634	nucleus
0.54	GO:0005667	transcription factor complex
0.45	GO:0044446	intracellular organelle part
0.39	GO:0005737	cytoplasm
0.35	GO:0005694	chromosome
0.35	GO:0043233	organelle lumen

tr|T1FY73|T1FY73_HELRO
Peroxisome assembly protein 12
Search

PEX12

0.82	Peroxisome assembly protein 12

0.79	GO:0072662	protein localization to peroxisome
0.79	GO:0043574	peroxisomal transport
0.71	GO:0072594	establishment of protein localization to organelle
0.69	GO:0006605	protein targeting
0.53	GO:0017038	protein import
0.52	GO:0065002	intracellular protein transmembrane transport
0.47	GO:0006513	protein monoubiquitination
0.32	GO:0016310	phosphorylation

0.81	GO:0008022	protein C-terminus binding
0.61	GO:0008270	zinc ion binding
0.44	GO:0004842	ubiquitin-protein transferase activity
0.33	GO:0016874	ligase activity
0.32	GO:0016301	kinase activity

0.78	GO:0005779	integral component of peroxisomal membrane
0.48	GO:1990429	peroxisomal importomer complex

0.33	EC:6	GO:0016874
0.44	KEGG:R03876	GO:0004842

tr|T1FY74|T1FY74_HELRO
Uncharacterized protein
Search

0.10	Thyroid adenoma associated (Fragment)

0.78	GO:1990798	pancreas regeneration
0.76	GO:0003323	type B pancreatic cell development
0.66	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
0.60	GO:0055088	lipid homeostasis
0.49	GO:1901895	negative regulation of calcium-transporting ATPase activity
0.48	GO:1990845	adaptive thermogenesis

0.40

GO:0005515

protein binding

0.53	GO:0005783	endoplasmic reticulum
0.44	GO:0098562	cytoplasmic side of membrane
0.42	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.41	GO:0031984	organelle subcompartment
0.30	GO:0031224	intrinsic component of membrane

tr|T1FY75|T1FY75_HELRO
Uncharacterized protein
Search

0.60	Vesicular glutamate transporter

0.55	GO:0055085	transmembrane transport
0.38	GO:0007601	visual perception
0.38	GO:0007268	chemical synaptic transmission
0.36	GO:0015813	L-glutamate transport
0.34	GO:0098700	neurotransmitter loading into synaptic vesicle
0.33	GO:0006914	autophagy
0.33	GO:0006486	protein glycosylation
0.33	GO:0015031	protein transport
0.32	GO:0006508	proteolysis

0.41	GO:0005509	calcium ion binding
0.36	GO:0005313	L-glutamate transmembrane transporter activity
0.34	GO:0016758	transferase activity, transferring hexosyl groups
0.33	GO:0008017	microtubule binding
0.32	GO:0008233	peptidase activity

0.37	GO:0030672	synaptic vesicle membrane
0.32	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.34

GO:0016758

tr|T1FY76|T1FY76_HELRO
Uncharacterized protein
Search

0.37	ATP-dependent RNA helicase vasa

0.43	GO:0010501	RNA secondary structure unwinding
0.42	GO:1990511	piRNA biosynthetic process
0.41	GO:0030317	flagellated sperm motility
0.41	GO:0043046	DNA methylation involved in gamete generation
0.41	GO:0010529	negative regulation of transposition
0.41	GO:0007141	male meiosis I
0.39	GO:0007283	spermatogenesis
0.39	GO:0007275	multicellular organism development
0.39	GO:0031047	gene silencing by RNA
0.39	GO:0030154	cell differentiation

0.65	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.42	GO:0008186	RNA-dependent ATPase activity
0.40	GO:0008270	zinc ion binding
0.38	GO:0140098	catalytic activity, acting on RNA
0.32	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

0.46	GO:0043186	P granule
0.41	GO:0048471	perinuclear region of cytoplasm
0.40	GO:0005730	nucleolus
0.37	GO:0033391	chromatoid body
0.36	GO:0010494	cytoplasmic stress granule
0.33	GO:0005838	proteasome regulatory particle
0.30	GO:0031224	intrinsic component of membrane

0.32

EC:3.5

GO:0016810

tr|T1FY77|T1FY77_HELRO
Uncharacterized protein
Search

0.79	Lysine acetyltransferase 14

0.54	GO:0016573	histone acetylation
0.52	GO:0000086	G2/M transition of mitotic cell cycle
0.43	GO:2000620	positive regulation of histone H4-K16 acetylation
0.42	GO:0036335	intestinal stem cell homeostasis
0.40	GO:0006338	chromatin remodeling
0.34	GO:0034729	histone H3-K79 methylation
0.33	GO:0051726	regulation of cell cycle
0.33	GO:0043504	mitochondrial DNA repair
0.32	GO:0035556	intracellular signal transduction
0.32	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.67	GO:0008080	N-acetyltransferase activity
0.38	GO:0046872	metal ion binding
0.35	GO:0030274	LIM domain binding
0.34	GO:0031151	histone methyltransferase activity (H3-K79 specific)
0.33	GO:0008297	single-stranded DNA exodeoxyribonuclease activity

0.80	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.67

GO:0008080

tr|T1FY78|T1FY78_HELRO
Uncharacterized protein
Search

0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.46	GO:1903898	negative regulation of PERK-mediated unfolded protein response
0.45	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway
0.45	GO:0036498	IRE1-mediated unfolded protein response
0.45	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway
0.45	GO:2000646	positive regulation of receptor catabolic process
0.45	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.45	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
0.45	GO:0007257	activation of JUN kinase activity
0.44	GO:0008286	insulin receptor signaling pathway

0.75	GO:0004725	protein tyrosine phosphatase activity
0.46	GO:0008092	cytoskeletal protein binding
0.43	GO:0046875	ephrin receptor binding
0.43	GO:0030971	receptor tyrosine kinase binding
0.42	GO:0045296	cadherin binding
0.38	GO:0008270	zinc ion binding
0.36	GO:0005158	insulin receptor binding
0.36	GO:0051721	protein phosphatase 2A binding
0.34	GO:0050254	rhodopsin kinase activity
0.34	GO:0005509	calcium ion binding

0.47	GO:0005856	cytoskeleton
0.45	GO:0097443	sorting endosome
0.44	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane
0.43	GO:0005769	early endosome
0.36	GO:0005886	plasma membrane
0.34	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.75

GO:0004725

tr|T1FY79|T1FY79_HELRO
Uncharacterized protein
Search

0.78	Lectin mannose-binding 2

0.50	GO:0050766	positive regulation of phagocytosis
0.48	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.36	GO:0001172	transcription, RNA-templated
0.36	GO:0019079	viral genome replication
0.36	GO:0048881	mechanosensory lateral line system development
0.35	GO:0050790	regulation of catalytic activity
0.35	GO:0015031	protein transport
0.34	GO:0016310	phosphorylation
0.34	GO:0007165	signal transduction
0.33	GO:0036211	protein modification process

0.50	GO:0005537	mannose binding
0.47	GO:0031072	heat shock protein binding
0.36	GO:0003968	RNA-directed 5'-3' RNA polymerase activity
0.36	GO:0004703	G-protein coupled receptor kinase activity
0.36	GO:0030234	enzyme regulator activity
0.33	GO:0046872	metal ion binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003723	RNA binding

0.49	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.46	GO:0009986	cell surface
0.45	GO:0005615	extracellular space
0.45	GO:0005794	Golgi apparatus
0.43	GO:0005887	integral component of plasma membrane
0.35	GO:0031982	vesicle
0.35	GO:0043230	extracellular organelle
0.35	GO:0098588	bounding membrane of organelle
0.35	GO:0031984	organelle subcompartment
0.34	GO:0048471	perinuclear region of cytoplasm

0.36

EC:2.7.7.48

GO:0003968

tr|T1FY80|T1FY80_HELRO
Uncharacterized protein
Search

NOTUM

0.96	NOTUM, palmitoleoyl-protein carboxylesterase

0.80	GO:1990697	protein depalmitoleylation
0.71	GO:0030178	negative regulation of Wnt signaling pathway
0.55	GO:0060828	regulation of canonical Wnt signaling pathway
0.43	GO:0006507	GPI anchor release
0.43	GO:0016055	Wnt signaling pathway
0.38	GO:0007399	nervous system development
0.37	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.37	GO:0000904	cell morphogenesis involved in differentiation
0.37	GO:0009952	anterior/posterior pattern specification
0.37	GO:0120036	plasma membrane bounded cell projection organization

0.81

GO:1990699

palmitoleyl hydrolase activity

0.41	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

tr|T1FY81|T1FY81_HELRO
Uncharacterized protein
Search

tr|T1FY82|T1FY82_HELRO
Uncharacterized protein
Search

0.61	Putative deoxyribonuclease TATDN2

0.59	GO:0006259	DNA metabolic process
0.43	GO:0034655	nucleobase-containing compound catabolic process
0.43	GO:0044265	cellular macromolecule catabolic process
0.35	GO:0036498	IRE1-mediated unfolded protein response
0.33	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.33	GO:0030262	apoptotic nuclear changes
0.33	GO:0006468	protein phosphorylation
0.33	GO:0034599	cellular response to oxidative stress

0.74	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters
0.35	GO:0051536	iron-sulfur cluster binding
0.33	GO:0008296	3'-5'-exodeoxyribonuclease activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0046872	metal ion binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.40	GO:0016607	nuclear speck
0.38	GO:0005829	cytosol

0.74

EC:3.1.21

GO:0016888

tr|T1FY83|T1FY83_HELRO
Uncharacterized protein
Search

CHKA

0.67	Choline kinase alpha

0.58	GO:0006657	CDP-choline pathway
0.55	GO:0016310	phosphorylation
0.53	GO:0006646	phosphatidylethanolamine biosynthetic process
0.41	GO:1904681	response to 3-methylcholanthrene
0.39	GO:0007517	muscle organ development
0.38	GO:0006580	ethanolamine metabolic process
0.38	GO:0019695	choline metabolic process
0.36	GO:0009636	response to toxic substance
0.34	GO:0006869	lipid transport
0.33	GO:0007165	signal transduction

0.60	GO:0004103	choline kinase activity
0.58	GO:0004305	ethanolamine kinase activity
0.53	GO:0004104	cholinesterase activity
0.50	GO:0042803	protein homodimerization activity
0.41	GO:0008144	drug binding
0.38	GO:0033265	choline binding
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0004871	signal transducer activity

0.35

GO:0005829

cytosol

0.60	EC:2.7.1.32	GO:0004103
0.60	KEGG:R01021	GO:0004103

tr|T1FY84|T1FY84_HELRO
Uncharacterized protein
Search

ZCCHC9

0.81	Zinc finger CCHC-type containing 9

0.41

GO:0010923

negative regulation of phosphatase activity

0.63	GO:0008270	zinc ion binding
0.51	GO:0003676	nucleic acid binding

tr|T1FY85|T1FY85_HELRO
Autophagy protein 5
Search

ATG5

0.71	Autophagy protein 5

0.77	GO:0006914	autophagy
0.49	GO:0006501	C-terminal protein lipidation
0.49	GO:0007033	vacuole organization
0.48	GO:0061726	mitochondrion disassembly
0.47	GO:0007507	heart development
0.46	GO:0042594	response to starvation
0.46	GO:0031669	cellular response to nutrient levels
0.46	GO:0070925	organelle assembly
0.46	GO:2000619	negative regulation of histone H4-K16 acetylation
0.45	GO:0071500	cellular response to nitrosative stress

0.46	GO:0019776	Atg8 ligase activity
0.34	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.33	GO:0005515	protein binding

0.84	GO:0034045	phagophore assembly site membrane
0.46	GO:0034274	Atg12-Atg5-Atg16 complex
0.44	GO:0005776	autophagosome
0.43	GO:0044233	ER-mitochondrion membrane contact site
0.43	GO:0005930	axoneme
0.33	GO:0030670	phagocytic vesicle membrane
0.33	GO:0005829	cytosol
0.32	GO:0030424	axon
0.30	GO:0016021	integral component of membrane

tr|T1FY86|T1FY86_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.36	GO:0007399	nervous system development
0.36	GO:0007163	establishment or maintenance of cell polarity
0.35	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
0.35	GO:0007423	sensory organ development
0.35	GO:0035329	hippo signaling
0.35	GO:0072137	condensed mesenchymal cell proliferation
0.35	GO:0007166	cell surface receptor signaling pathway
0.35	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation
0.35	GO:0043931	ossification involved in bone maturation

0.70	GO:0005509	calcium ion binding
0.34	GO:0004930	G-protein coupled receptor activity
0.34	GO:0045296	cadherin binding
0.34	GO:0045295	gamma-catenin binding
0.33	GO:0032794	GTPase activating protein binding
0.33	GO:0030506	ankyrin binding
0.33	GO:0008013	beta-catenin binding
0.33	GO:0042802	identical protein binding

0.56	GO:0005886	plasma membrane
0.38	GO:0005911	cell-cell junction
0.37	GO:0120025	plasma membrane bounded cell projection
0.36	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0031252	cell leading edge
0.36	GO:0097458	neuron part
0.36	GO:0030427	site of polarized growth
0.35	GO:0044463	cell projection part
0.34	GO:0045177	apical part of cell
0.34	GO:0005634	nucleus

tr|T1FY87|T1FY87_HELRO
Uncharacterized protein
Search

0.80	Dynein axonemal heavy chain 7

0.74	GO:0007018	microtubule-based movement
0.52	GO:0036159	inner dynein arm assembly
0.39	GO:0071910	determination of liver left/right asymmetry
0.37	GO:0030705	cytoskeleton-dependent intracellular transport
0.35	GO:0060285	cilium-dependent cell motility
0.35	GO:0061817	endoplasmic reticulum-plasma membrane tethering
0.34	GO:0006869	lipid transport

0.75	GO:0003777	microtubule motor activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0016887	ATPase activity
0.51	GO:0045503	dynein light chain binding
0.51	GO:0051959	dynein light intermediate chain binding
0.51	GO:0045505	dynein intermediate chain binding
0.48	GO:0005509	calcium ion binding
0.34	GO:0008289	lipid binding

0.78	GO:0030286	dynein complex
0.51	GO:0032838	plasma membrane bounded cell projection cytoplasm
0.49	GO:0044441	ciliary part
0.39	GO:0005829	cytosol
0.37	GO:0033267	axon part
0.34	GO:0005874	microtubule
0.30	GO:0031224	intrinsic component of membrane

0.52

GO:0016887

tr|T1FY88|T1FY88_HELRO
Uncharacterized protein
Search

0.44	Plancitoxin-1

0.60	GO:0006259	DNA metabolic process
0.43	GO:0006915	apoptotic process
0.40	GO:0022411	cellular component disassembly
0.39	GO:0034655	nucleobase-containing compound catabolic process
0.39	GO:0010623	programmed cell death involved in cell development
0.39	GO:0044265	cellular macromolecule catabolic process
0.38	GO:0048477	oogenesis
0.38	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.34	GO:0006413	translational initiation
0.33	GO:0007165	signal transduction

0.84	GO:0004531	deoxyribonuclease II activity
0.41	GO:0043022	ribosome binding
0.40	GO:0005509	calcium ion binding
0.34	GO:0003743	translation initiation factor activity

0.38	GO:0005739	mitochondrion
0.34	GO:0005615	extracellular space
0.30	GO:0016020	membrane

0.84

EC:3.1.22.1

GO:0004531

tr|T1FY89|T1FY89_HELRO
Uncharacterized protein
Search

TNPO1

0.81	Putative nuclear transport receptor karyopherin-beta2/transportin importin beta superfamily

0.69	GO:0006886	intracellular protein transport
0.47	GO:0006610	ribosomal protein import into nucleus
0.46	GO:0006607	NLS-bearing protein import into nucleus
0.35	GO:0010469	regulation of receptor activity

0.80	GO:0008536	Ran GTPase binding
0.46	GO:0008139	nuclear localization sequence binding
0.42	GO:0008565	protein transporter activity
0.35	GO:0005179	hormone activity
0.33	GO:0003723	RNA binding

0.58	GO:0005634	nucleus
0.41	GO:0012505	endomembrane system
0.41	GO:0031974	membrane-enclosed lumen
0.39	GO:0031967	organelle envelope
0.39	GO:0031090	organelle membrane
0.36	GO:0005737	cytoplasm
0.35	GO:0005576	extracellular region
0.33	GO:0031982	vesicle
0.30	GO:0031224	intrinsic component of membrane

tr|T1FY90|T1FY90_HELRO
Uncharacterized protein
Search

0.10	Chloride intracellular channel

0.78	GO:0048060	negative gravitaxis
0.73	GO:1902476	chloride transmembrane transport
0.68	GO:0097305	response to alcohol
0.54	GO:0006749	glutathione metabolic process
0.43	GO:0034765	regulation of ion transmembrane transport

0.73	GO:0005254	chloride channel activity
0.61	GO:0008289	lipid binding
0.60	GO:0005509	calcium ion binding
0.56	GO:0004364	glutathione transferase activity
0.43	GO:0022832	voltage-gated channel activity
0.42	GO:0022839	ion gated channel activity
0.42	GO:0008381	mechanosensitive ion channel activity

0.53	GO:0005739	mitochondrion
0.47	GO:0005634	nucleus
0.45	GO:0034707	chloride channel complex
0.41	GO:0005829	cytosol
0.41	GO:0031974	membrane-enclosed lumen
0.38	GO:0044446	intracellular organelle part

0.56

EC:2.5.1.18

GO:0004364

tr|T1FY91|T1FY91_HELRO
Uncharacterized protein
Search

0.10	Ankyrin repeat and sterile alpha motif domain containing 1A (Fragment)

0.86	GO:1901187	regulation of ephrin receptor signaling pathway
0.39	GO:0006929	substrate-dependent cell migration
0.39	GO:0016322	neuron remodeling
0.39	GO:0048013	ephrin receptor signaling pathway
0.38	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.32	GO:0006508	proteolysis
0.32	GO:0016310	phosphorylation

0.84	GO:0046875	ephrin receptor binding
0.32	GO:0070001	aspartic-type peptidase activity
0.32	GO:0004175	endopeptidase activity
0.32	GO:0016301	kinase activity

0.46	GO:0005654	nucleoplasm
0.45	GO:0005829	cytosol
0.38	GO:0043005	neuron projection

tr|T1FY92|T1FY92_HELRO
Uncharacterized protein
Search

tr|T1FY93|T1FY93_HELRO
Uncharacterized protein
Search

0.58	GO:0006508	proteolysis
0.48	GO:0071406	cellular response to methylmercury
0.42	GO:0043632	modification-dependent macromolecule catabolic process
0.42	GO:0044257	cellular protein catabolic process

0.65	GO:0004222	metalloendopeptidase activity
0.59	GO:0008270	zinc ion binding

0.45	GO:0019005	SCF ubiquitin ligase complex
0.30	GO:0031224	intrinsic component of membrane

0.65

GO:0004222

tr|T1FY94|T1FY94_HELRO
Uncharacterized protein
Search

tr|T1FY95|T1FY95_HELRO
Uncharacterized protein
Search

RNPC3

0.67	RNA-binding protein 40

0.49	GO:0000398	mRNA splicing, via spliceosome
0.48	GO:0010229	inflorescence development
0.40	GO:0031016	pancreas development
0.40	GO:0001889	liver development
0.40	GO:0048565	digestive tract development
0.34	GO:0005975	carbohydrate metabolic process
0.33	GO:0007165	signal transduction

0.59	GO:0003723	RNA binding
0.37	GO:0103025	alpha-amylase activity (releasing maltohexaose)
0.37	GO:0004556	alpha-amylase activity
0.33	GO:0043169	cation binding
0.33	GO:0004871	signal transducer activity
0.32	GO:0003677	DNA binding

0.48	GO:0005689	U12-type spliceosomal complex
0.38	GO:0005654	nucleoplasm
0.35	GO:0017053	transcriptional repressor complex
0.30	GO:0031224	intrinsic component of membrane

0.37

EC:3.2.1.1

GO:0004556

tr|T1FY96|T1FY96_HELRO
Uncharacterized protein
Search

0.72	RUN and FYVE domain-containing protein 2

0.50	GO:0030100	regulation of endocytosis
0.43	GO:0015031	protein transport
0.35	GO:0006661	phosphatidylinositol biosynthetic process
0.34	GO:0006897	endocytosis

0.53	GO:0046872	metal ion binding
0.52	GO:0042169	SH2 domain binding
0.50	GO:0017124	SH3 domain binding
0.45	GO:0008565	protein transporter activity
0.34	GO:0008289	lipid binding

0.49	GO:0016607	nuclear speck
0.47	GO:0005768	endosome
0.45	GO:0005829	cytosol
0.34	GO:0044433	cytoplasmic vesicle part
0.34	GO:0098805	whole membrane
0.34	GO:0098588	bounding membrane of organelle
0.30	GO:0031224	intrinsic component of membrane

tr|T1FY97|T1FY97_HELRO
Proteasome subunit beta
Search

0.56	Proteasome subunit beta

0.71	GO:0051603	proteolysis involved in cellular protein catabolic process
0.41	GO:0043248	proteasome assembly
0.39	GO:0043632	modification-dependent macromolecule catabolic process
0.38	GO:0002862	negative regulation of inflammatory response to antigenic stimulus
0.33	GO:0006357	regulation of transcription by RNA polymerase II
0.32	GO:0016310	phosphorylation

0.76	GO:0070003	threonine-type peptidase activity
0.64	GO:0004175	endopeptidase activity
0.37	GO:0001530	lipopolysaccharide binding
0.33	GO:0003951	NAD+ kinase activity
0.32	GO:0003677	DNA binding

0.75	GO:0005839	proteasome core complex
0.60	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.33	EC:2.7.1.23	GO:0003951
0.33	KEGG:R00104	GO:0003951

tr|T1FY98|T1FY98_HELRO
Uncharacterized protein
Search

UBR2

0.59	Ubiquitin protein ligase E3 component n-recognin 2

0.70	GO:0030163	protein catabolic process
0.50	GO:0033522	histone H2A ubiquitination
0.49	GO:0071233	cellular response to leucine
0.48	GO:0010529	negative regulation of transposition
0.48	GO:0007141	male meiosis I
0.48	GO:0006342	chromatin silencing
0.47	GO:0032007	negative regulation of TOR signaling
0.46	GO:0007131	reciprocal meiotic recombination
0.46	GO:0043632	modification-dependent macromolecule catabolic process
0.46	GO:0007283	spermatogenesis

0.63	GO:0008270	zinc ion binding
0.54	GO:0016874	ligase activity
0.50	GO:0070728	leucine binding
0.48	GO:0061630	ubiquitin protein ligase activity
0.33	GO:0005515	protein binding

0.47	GO:0000151	ubiquitin ligase complex
0.43	GO:0000785	chromatin
0.35	GO:0005737	cytoplasm
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.54

GO:0016874

tr|T1FY99|T1FY99_HELRO
Uncharacterized protein
Search

0.72	Piwi like RNA-mediated gene silencing 2

0.78	GO:0031047	gene silencing by RNA
0.44	GO:0007283	spermatogenesis
0.43	GO:0007281	germ cell development
0.41	GO:0010529	negative regulation of transposition
0.39	GO:0006413	translational initiation
0.39	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
0.39	GO:0034587	piRNA metabolic process
0.38	GO:0016441	posttranscriptional gene silencing
0.37	GO:0071442	positive regulation of histone H3-K14 acetylation
0.36	GO:0060903	positive regulation of meiosis I

0.51	GO:0003676	nucleic acid binding
0.35	GO:0004519	endonuclease activity
0.34	GO:0004540	ribonuclease activity
0.34	GO:0005515	protein binding
0.33	GO:0046872	metal ion binding
0.32	GO:0051536	iron-sulfur cluster binding

0.42	GO:0043186	P granule
0.37	GO:0010370	perinucleolar chromocenter
0.37	GO:1990923	PET complex
0.36	GO:0033391	chromatoid body
0.36	GO:0097433	dense body
0.36	GO:0005829	cytosol
0.36	GO:0005844	polysome
0.35	GO:0043227	membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane

tr|T1FYA0|T1FYA0_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.63	GO:0001955	blood vessel maturation
0.54	GO:1901552	positive regulation of endothelial cell development
0.53	GO:1903140	regulation of establishment of endothelial barrier
0.51	GO:0050728	negative regulation of inflammatory response
0.51	GO:0007043	cell-cell junction assembly
0.51	GO:0007179	transforming growth factor beta receptor signaling pathway
0.50	GO:0045766	positive regulation of angiogenesis
0.49	GO:2000114	regulation of establishment of cell polarity
0.49	GO:0008285	negative regulation of cell proliferation

0.70	GO:0005509	calcium ion binding
0.51	GO:0044325	ion channel binding
0.51	GO:0008013	beta-catenin binding
0.50	GO:0019903	protein phosphatase binding
0.47	GO:0005102	receptor binding

0.56	GO:0005886	plasma membrane
0.53	GO:0005913	cell-cell adherens junction
0.49	GO:0005923	bicellular tight junction
0.48	GO:0009986	cell surface
0.47	GO:0098552	side of membrane
0.40	GO:0032420	stereocilium
0.35	GO:0070062	extracellular exosome
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

tr|T1FYA1|T1FYA1_HELRO
Uncharacterized protein
Search

BLCAP

0.96	Bladder cancer-associated protein (Fragment)

0.51	GO:0030262	apoptotic nuclear changes
0.37	GO:0007049	cell cycle

0.32

GO:0005515

protein binding

0.30

GO:0044425

membrane part

tr|T1FYA2|T1FYA2_HELRO
Uncharacterized protein
Search

tr|T1FYA3|T1FYA3_HELRO
Uncharacterized protein
Search

MON1A

0.90	Vacuolar fusion protein MON1 like protein A

0.67	GO:0016192	vesicle-mediated transport
0.57	GO:0009306	protein secretion
0.55	GO:0007041	lysosomal transport
0.52	GO:0016197	endosomal transport
0.49	GO:0007528	neuromuscular junction development
0.40	GO:2000643	positive regulation of early endosome to late endosome transport
0.40	GO:0090382	phagosome maturation
0.39	GO:0002119	nematode larval development
0.39	GO:0010171	body morphogenesis
0.39	GO:0065009	regulation of molecular function

0.42	GO:0005085	guanyl-nucleotide exchange factor activity
0.38	GO:0005216	ion channel activity

0.63	GO:0012505	endomembrane system
0.50	GO:0043083	synaptic cleft
0.45	GO:0005829	cytosol
0.37	GO:0031410	cytoplasmic vesicle
0.30	GO:0016020	membrane

tr|T1FYA4|T1FYA4_HELRO
Uncharacterized protein
Search

QDPR

0.62	Quinoid dihydropteridine reductase a

0.51	GO:0055114	oxidation-reduction process
0.40	GO:0010288	response to lead ion
0.40	GO:0046146	tetrahydrobiopterin metabolic process
0.40	GO:0034312	diol biosynthetic process
0.40	GO:0010044	response to aluminum ion
0.39	GO:0033762	response to glucagon
0.39	GO:0001889	liver development
0.38	GO:0042559	pteridine-containing compound biosynthetic process
0.38	GO:0035690	cellular response to drug
0.38	GO:1902222	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process

0.52	GO:0016491	oxidoreductase activity
0.40	GO:0070404	NADH binding
0.38	GO:0070402	NADPH binding
0.37	GO:0042803	protein homodimerization activity
0.33	GO:0016875	ligase activity, forming carbon-oxygen bonds
0.33	GO:0140101	catalytic activity, acting on a tRNA
0.32	GO:0005524	ATP binding

0.43	GO:0005739	mitochondrion
0.38	GO:0043005	neuron projection
0.36	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome

0.52

GO:0016491

tr|T1FYA5|T1FYA5_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.48	GO:0072137	condensed mesenchymal cell proliferation
0.48	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation
0.48	GO:0060122	inner ear receptor cell stereocilium organization
0.47	GO:0043931	ossification involved in bone maturation
0.47	GO:0001658	branching involved in ureteric bud morphogenesis
0.46	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
0.46	GO:0035329	hippo signaling
0.46	GO:0021987	cerebral cortex development
0.45	GO:0008543	fibroblast growth factor receptor signaling pathway

0.70	GO:0005509	calcium ion binding
0.36	GO:0005515	protein binding
0.33	GO:0004930	G-protein coupled receptor activity

0.56	GO:0005886	plasma membrane
0.45	GO:0045177	apical part of cell
0.36	GO:0032420	stereocilium
0.35	GO:0070062	extracellular exosome
0.35	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

tr|T1FYA6|T1FYA6_HELRO
Receptor expression-enhancing protein
Search

0.49	Receptor expression-enhancing protein (Fragment)

0.53	GO:0007084	mitotic nuclear envelope reassembly
0.43	GO:0032596	protein transport into membrane raft
0.43	GO:0050916	sensory perception of sweet taste
0.43	GO:0071786	endoplasmic reticulum tubular network organization
0.42	GO:0050913	sensory perception of bitter taste
0.41	GO:0032386	regulation of intracellular transport
0.36	GO:0051301	cell division

0.44	GO:0031883	taste receptor binding
0.34	GO:0008017	microtubule binding

0.44	GO:0005783	endoplasmic reticulum
0.41	GO:0005881	cytoplasmic microtubule
0.41	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.40	GO:0031984	organelle subcompartment
0.38	GO:0005887	integral component of plasma membrane
0.34	GO:0070062	extracellular exosome

tr|T1FYA7|T1FYA7_HELRO
Uncharacterized protein
Search

0.39	Likely protein kinase

0.86	GO:0010619	adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway
0.86	GO:1903759	signal transduction involved in regulation of aerobic respiration
0.86	GO:0010515	negative regulation of induction of conjugation with cellular fusion
0.86	GO:0045014	negative regulation of transcription by glucose
0.85	GO:0046827	positive regulation of protein export from nucleus
0.85	GO:0051447	negative regulation of meiotic cell cycle
0.63	GO:0006468	protein phosphorylation

0.85	GO:0004691	cAMP-dependent protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.84	GO:0005952	cAMP-dependent protein kinase complex
0.80	GO:0000324	fungal-type vacuole
0.61	GO:0005634	nucleus

0.85

EC:2.7.11.11

GO:0004691

tr|T1FYA8|T1FYA8_HELRO
Uncharacterized protein
Search

tr|T1FYA9|T1FYA9_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.51	GO:0007416	synapse assembly
0.50	GO:0007267	cell-cell signaling
0.47	GO:0001756	somitogenesis
0.46	GO:0016331	morphogenesis of embryonic epithelium
0.39	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
0.36	GO:0016336	establishment or maintenance of polarity of larval imaginal disc epithelium
0.36	GO:0045317	equator specification
0.36	GO:0090176	microtubule cytoskeleton organization involved in establishment of planar polarity
0.36	GO:0045571	negative regulation of imaginal disc growth

0.70	GO:0005509	calcium ion binding
0.36	GO:0042802	identical protein binding
0.35	GO:0045296	cadherin binding
0.34	GO:0003743	translation initiation factor activity

0.55	GO:0005886	plasma membrane
0.43	GO:0032391	photoreceptor connecting cilium
0.43	GO:0030054	cell junction
0.41	GO:0098794	postsynapse
0.40	GO:0001750	photoreceptor outer segment
0.37	GO:0098588	bounding membrane of organelle
0.37	GO:0030425	dendrite
0.37	GO:0098793	presynapse
0.32	GO:0005622	intracellular
0.30	GO:0031224	intrinsic component of membrane

tr|T1FYB0|T1FYB0_HELRO
Uncharacterized protein
Search

TEKT4

0.86	Tektin-4 isoform B

0.85	GO:0060294	cilium movement involved in cell motility
0.81	GO:0030317	flagellated sperm motility
0.75	GO:0060271	cilium assembly
0.45	GO:0046692	sperm competition
0.43	GO:0007020	microtubule nucleation

0.42	GO:0005200	structural constituent of cytoskeleton
0.40	GO:0005515	protein binding

0.80	GO:0036126	sperm flagellum
0.58	GO:0005634	nucleus
0.53	GO:0015630	microtubule cytoskeleton
0.47	GO:0044430	cytoskeletal part
0.47	GO:0099512	supramolecular fiber
0.39	GO:0005737	cytoplasm
0.36	GO:0043234	protein complex

tr|T1FYB1|T1FYB1_HELRO
Uncharacterized protein
Search

0.47	Amine sulfotransferase

0.53	GO:0042403	thyroid hormone metabolic process
0.52	GO:0051923	sulfation
0.49	GO:0006805	xenobiotic metabolic process
0.44	GO:0006068	ethanol catabolic process
0.44	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
0.43	GO:0009812	flavonoid metabolic process
0.41	GO:0030855	epithelial cell differentiation
0.37	GO:0006584	catecholamine metabolic process
0.37	GO:0008202	steroid metabolic process
0.36	GO:0000103	sulfate assimilation

0.78	GO:0008146	sulfotransferase activity
0.34	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding
0.33	GO:0005515	protein binding

0.34	GO:0005829	cytosol
0.33	GO:0005764	lysosome
0.30	GO:0031224	intrinsic component of membrane

0.78

EC:2.8.2

GO:0008146

tr|T1FYB2|T1FYB2_HELRO
Uncharacterized protein
Search

0.10

Ankyrin-3

0.61	GO:0007165	signal transduction
0.38	GO:0007016	cytoskeletal anchoring at plasma membrane

0.40	GO:0045170	spectrosome
0.34	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

tr|T1FYB3|T1FYB3_HELRO
Uncharacterized protein
Search

SLC35C1

0.87	GDP-fucose transporter

0.85	GO:0036085	GDP-fucose import into Golgi lumen
0.52	GO:0045746	negative regulation of Notch signaling pathway
0.49	GO:0030259	lipid glycosylation
0.37	GO:0008643	carbohydrate transport

0.85	GO:0005457	GDP-fucose transmembrane transporter activity
0.33	GO:0046872	metal ion binding

0.71	GO:0005794	Golgi apparatus
0.37	GO:0098588	bounding membrane of organelle
0.36	GO:0031984	organelle subcompartment
0.34	GO:0031417	NatC complex
0.30	GO:0044425	membrane part

tr|T1FYB4|T1FYB4_HELRO
Uncharacterized protein
Search

tr|T1FYB5|T1FYB5_HELRO
Uncharacterized protein
Search

0.50	GO:0043277	apoptotic cell clearance
0.50	GO:0006910	phagocytosis, recognition
0.49	GO:0050766	positive regulation of phagocytosis
0.49	GO:0006911	phagocytosis, engulfment
0.38	GO:0006508	proteolysis

0.56	GO:0070492	oligosaccharide binding
0.50	GO:0008429	phosphatidylethanolamine binding
0.50	GO:0001786	phosphatidylserine binding
0.49	GO:0005509	calcium ion binding
0.49	GO:0005178	integrin binding
0.40	GO:0070001	aspartic-type peptidase activity
0.39	GO:0004175	endopeptidase activity
0.39	GO:0008270	zinc ion binding
0.36	GO:0003676	nucleic acid binding

0.48	GO:0009897	external side of plasma membrane
0.46	GO:0019897	extrinsic component of plasma membrane
0.45	GO:0031012	extracellular matrix
0.45	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane

tr|T1FYB6|T1FYB6_HELRO
Uncharacterized protein
Search

0.10	Protein IMPACT homolog (inferred by orthology to a C. elegans protein)

0.81	GO:0060733	regulation of eIF2 alpha phosphorylation by amino acid starvation
0.76	GO:1901561	response to benomyl
0.75	GO:0071494	cellular response to UV-C
0.74	GO:1990253	cellular response to leucine starvation
0.73	GO:0071264	positive regulation of translational initiation in response to starvation
0.73	GO:0031333	negative regulation of protein complex assembly
0.73	GO:0031953	negative regulation of protein autophosphorylation
0.73	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress
0.73	GO:0071468	cellular response to acidic pH
0.71	GO:0070301	cellular response to hydrogen peroxide

0.65	GO:0043022	ribosome binding
0.64	GO:0003779	actin binding
0.55	GO:0004860	protein kinase inhibitor activity
0.51	GO:0004969	histamine receptor activity
0.39	GO:0046983	protein dimerization activity
0.37	GO:0008483	transaminase activity
0.36	GO:0030170	pyridoxal phosphate binding

0.75	GO:0005844	polysome
0.45	GO:0005840	ribosome
0.37	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.37

EC:2.6.1

GO:0008483

tr|T1FYB7|T1FYB7_HELRO
Uncharacterized protein
Search

tr|T1FYB8|T1FYB8_HELRO
Uncharacterized protein
Search

0.41	GO:0019722	calcium-mediated signaling
0.41	GO:0009737	response to abscisic acid
0.41	GO:0009414	response to water deprivation
0.41	GO:0009651	response to salt stress
0.39	GO:0005513	detection of calcium ion
0.38	GO:0006468	protein phosphorylation

0.70	GO:0005509	calcium ion binding
0.52	GO:0070855	myosin VI head/neck binding
0.38	GO:0004672	protein kinase activity
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding

0.52	GO:0031476	myosin VI complex
0.51	GO:0070865	investment cone
0.42	GO:0005634	nucleus
0.38	GO:0005829	cytosol

tr|T1FYB9|T1FYB9_HELRO
Uncharacterized protein
Search

0.97	Hepatocyte nuclear factor 6 alpha (Fragment)

0.46	GO:0048536	spleen development
0.46	GO:0031018	endocrine pancreas development
0.45	GO:0030183	B cell differentiation
0.45	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.45	GO:0007492	endoderm development
0.45	GO:0001952	regulation of cell-matrix adhesion
0.45	GO:0001889	liver development
0.44	GO:0007219	Notch signaling pathway
0.44	GO:0002064	epithelial cell development
0.44	GO:0030335	positive regulation of cell migration

0.55	GO:0003677	DNA binding
0.44	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.41	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

0.61	GO:0005634	nucleus
0.37	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part

tr|T1FYC0|T1FYC0_HELRO
Uncharacterized protein
Search

0.61	GO:0035385	Roundabout signaling pathway
0.60	GO:0007411	axon guidance
0.58	GO:0001822	kidney development
0.41	GO:0048646	anatomical structure formation involved in morphogenesis
0.41	GO:0072359	circulatory system development
0.41	GO:0030334	regulation of cell migration
0.41	GO:0048518	positive regulation of biological process
0.40	GO:0030510	regulation of BMP signaling pathway
0.40	GO:0071711	basement membrane organization
0.40	GO:0008038	neuron recognition

0.44	GO:0005509	calcium ion binding
0.38	GO:0004672	protein kinase activity
0.37	GO:0005515	protein binding
0.37	GO:0004872	receptor activity
0.37	GO:0005201	extracellular matrix structural constituent
0.36	GO:0017076	purine nucleotide binding
0.36	GO:0097367	carbohydrate derivative binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0008144	drug binding
0.35	GO:0098772	molecular function regulator

0.61	GO:0030673	axolemma
0.43	GO:0005604	basement membrane
0.42	GO:0005581	collagen trimer
0.38	GO:0005938	cell cortex
0.38	GO:0030054	cell junction
0.37	GO:0005887	integral component of plasma membrane
0.36	GO:0044295	axonal growth cone
0.35	GO:0043025	neuronal cell body
0.35	GO:0030425	dendrite
0.35	GO:0009897	external side of plasma membrane

tr|T1FYC1|T1FYC1_HELRO
Uncharacterized protein
Search

SF3B5

0.86	Splicing factor 3B subunit 5

0.75	GO:0000398	mRNA splicing, via spliceosome
0.41	GO:0007283	spermatogenesis
0.34	GO:0038003	opioid receptor signaling pathway
0.34	GO:0007218	neuropeptide signaling pathway

0.34	GO:0004979	beta-endorphin receptor activity
0.33	GO:0003723	RNA binding

0.52	GO:0005689	U12-type spliceosomal complex
0.48	GO:0005686	U2 snRNP
0.46	GO:0071011	precatalytic spliceosome
0.43	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

tr|T1FYC2|T1FYC2_HELRO
Uncharacterized protein
Search

tr|T1FYC3|T1FYC3_HELRO
Uncharacterized protein
Search

0.58	UDP-glucose:glycoprotein glucosyltransferase

0.61	GO:0098655	cation transmembrane transport
0.44	GO:0010043	response to zinc ion
0.43	GO:0061088	regulation of sequestering of zinc ion
0.42	GO:0006829	zinc II ion transport
0.40	GO:0097359	UDP-glucosylation
0.40	GO:0006882	cellular zinc ion homeostasis
0.38	GO:0098660	inorganic ion transmembrane transport
0.38	GO:0043413	macromolecule glycosylation
0.38	GO:0009101	glycoprotein biosynthetic process
0.37	GO:0097501	stress response to metal ion

0.61	GO:0008324	cation transmembrane transporter activity
0.40	GO:0003980	UDP-glucose:glycoprotein glucosyltransferase activity
0.38	GO:0015318	inorganic molecular entity transmembrane transporter activity
0.37	GO:0031491	nucleosome binding
0.35	GO:0004386	helicase activity
0.35	GO:0004862	cAMP-dependent protein kinase inhibitor activity
0.34	GO:0016887	ATPase activity
0.34	GO:0042803	protein homodimerization activity
0.34	GO:0004930	G-protein coupled receptor activity
0.33	GO:0030554	adenyl nucleotide binding

0.38	GO:0031410	cytoplasmic vesicle
0.37	GO:0016589	NURF complex
0.36	GO:0016323	basolateral plasma membrane
0.36	GO:0012505	endomembrane system
0.30	GO:0016021	integral component of membrane

0.40

GO:0003980

tr|T1FYC4|T1FYC4_HELRO
Uncharacterized protein
Search

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.52	GO:0001712	ectodermal cell fate commitment
0.51	GO:0090009	primitive streak formation
0.51	GO:0007498	mesoderm development
0.46	GO:1902680	positive regulation of RNA biosynthetic process
0.45	GO:1902679	negative regulation of RNA biosynthetic process
0.42	GO:0035779	angioblast cell differentiation
0.41	GO:0030223	neutrophil differentiation

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.47	GO:0001012	RNA polymerase II regulatory region DNA binding
0.47	GO:0019904	protein domain specific binding
0.45	GO:0003690	double-stranded DNA binding
0.38	GO:0035259	glucocorticoid receptor binding

0.61	GO:0005634	nucleus
0.44	GO:0005829	cytosol
0.44	GO:0031974	membrane-enclosed lumen
0.40	GO:0044446	intracellular organelle part
0.39	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1FYC5|T1FYC5_HELRO
Uncharacterized protein
Search

0.10	Transcriptional adapter

0.79	GO:0035065	regulation of histone acetylation
0.67	GO:0006357	regulation of transcription by RNA polymerase II
0.54	GO:0006351	transcription, DNA-templated
0.54	GO:0090043	regulation of tubulin deacetylation
0.52	GO:0031063	regulation of histone deacetylation
0.50	GO:2000758	positive regulation of peptidyl-lysine acetylation
0.49	GO:0031058	positive regulation of histone modification
0.49	GO:0031647	regulation of protein stability
0.47	GO:0000278	mitotic cell cycle
0.47	GO:0016573	histone acetylation

0.75	GO:0003713	transcription coactivator activity
0.55	GO:0003677	DNA binding
0.47	GO:0004402	histone acetyltransferase activity
0.46	GO:0003682	chromatin binding
0.41	GO:0008270	zinc ion binding
0.40	GO:0001786	phosphatidylserine binding
0.40	GO:0003700	DNA binding transcription factor activity
0.36	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.34	GO:0005515	protein binding
0.34	GO:1901265	nucleoside phosphate binding

0.60	GO:0005634	nucleus
0.52	GO:0031248	protein acetyltransferase complex
0.49	GO:0072686	mitotic spindle
0.48	GO:0031974	membrane-enclosed lumen
0.44	GO:0043234	protein complex
0.39	GO:0005694	chromosome
0.38	GO:1905368	peptidase complex
0.30	GO:0016020	membrane

0.47

GO:0004402

tr|T1FYC6|T1FYC6_HELRO
Uncharacterized protein
Search

tr|T1FYC7|T1FYC7_HELRO
Synaptotagmin 45
Search

0.48	Synaptotagmin 1

0.69	GO:0017158	regulation of calcium ion-dependent exocytosis
0.60	GO:0061817	endoplasmic reticulum-plasma membrane tethering
0.54	GO:0006869	lipid transport
0.53	GO:0099643	signal release from synapse
0.53	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.50	GO:0006836	neurotransmitter transport
0.49	GO:0001505	regulation of neurotransmitter levels
0.48	GO:1903307	positive regulation of regulated secretory pathway
0.47	GO:0051649	establishment of localization in cell
0.46	GO:0017156	calcium ion regulated exocytosis

0.59	GO:0008289	lipid binding
0.47	GO:0000149	SNARE binding
0.44	GO:0042803	protein homodimerization activity
0.44	GO:0072341	modified amino acid binding
0.44	GO:0005509	calcium ion binding
0.44	GO:0046982	protein heterodimerization activity
0.43	GO:0030276	clathrin binding
0.41	GO:0043168	anion binding
0.35	GO:0016301	kinase activity
0.34	GO:0017137	Rab GTPase binding

0.54	GO:0070382	exocytic vesicle
0.51	GO:0098793	presynapse
0.38	GO:0030658	transport vesicle membrane
0.37	GO:0005886	plasma membrane
0.33	GO:0005783	endoplasmic reticulum
0.33	GO:0030054	cell junction
0.30	GO:0016021	integral component of membrane

0.33	EC:2.7.1	GO:0016773
0.33	KEGG:R00112	GO:0008746

tr|T1FYC8|T1FYC8_HELRO
Uncharacterized protein
Search

0.71	GO:0034599	cellular response to oxidative stress
0.41	GO:0035023	regulation of Rho protein signal transduction
0.38	GO:0065009	regulation of molecular function

0.41

GO:0005089

Rho guanyl-nucleotide exchange factor activity

0.59

GO:0005739

mitochondrion

tr|T1FYC9|T1FYC9_HELRO
Uncharacterized protein
Search

0.62	Thyrotroph embryonic factor

0.70	GO:0006357	regulation of transcription by RNA polymerase II
0.43	GO:0006366	transcription by RNA polymerase II
0.43	GO:0045893	positive regulation of transcription, DNA-templated
0.42	GO:0007275	multicellular organism development
0.40	GO:0048511	rhythmic process

0.64	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.44	GO:0001012	RNA polymerase II regulatory region DNA binding
0.42	GO:0003690	double-stranded DNA binding
0.37	GO:0005515	protein binding

0.61

GO:0005634

nucleus

tr|T1FYD0|T1FYD0_HELRO
Uncharacterized protein
Search

0.69	Ng-dimethylarginine dimethylaminohydrolase

0.39	GO:0000052	citrulline metabolic process
0.38	GO:0045429	positive regulation of nitric oxide biosynthetic process
0.37	GO:0006527	arginine catabolic process

0.51	GO:0016787	hydrolase activity
0.34	GO:0016740	transferase activity

0.30

GO:0044425

membrane part

0.51

GO:0016787

tr|T1FYD1|T1FYD1_HELRO
Uncharacterized protein
Search

0.77	multidrug resistance protein 1-like

0.55	GO:0055085	transmembrane transport
0.53	GO:1903793	positive regulation of anion transport
0.50	GO:0099040	ceramide translocation
0.50	GO:0045332	phospholipid translocation
0.49	GO:1901557	response to fenofibrate
0.49	GO:1903413	cellular response to bile acid
0.48	GO:0032782	bile acid secretion
0.48	GO:0061091	regulation of phospholipid translocation
0.48	GO:2001225	regulation of chloride transport
0.47	GO:0010359	regulation of anion channel activity

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.56	GO:0090554	phosphatidylcholine-translocating ATPase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.50	GO:0099038	ceramide-translocating ATPase activity
0.49	GO:0090555	phosphatidylethanolamine-translocating ATPase activity
0.44	GO:0042910	xenobiotic transmembrane transporter activity
0.42	GO:0015238	drug transmembrane transporter activity

0.51	GO:0016324	apical plasma membrane
0.49	GO:0046581	intercellular canaliculus
0.44	GO:0005925	focal adhesion
0.43	GO:0009986	cell surface
0.42	GO:0015629	actin cytoskeleton
0.41	GO:0005654	nucleoplasm
0.41	GO:0005829	cytosol
0.39	GO:0031526	brush border membrane
0.39	GO:0070062	extracellular exosome
0.37	GO:0098857	membrane microdomain

0.33

GO:0016757

tr|T1FYD2|T1FYD2_HELRO
Uncharacterized protein
Search

tr|T1FYD3|T1FYD3_HELRO
Uncharacterized protein
Search

0.51	Serine/threonine-protein kinase PAK 3

0.63	GO:0006468	protein phosphorylation
0.41	GO:0042981	regulation of apoptotic process
0.41	GO:0045860	positive regulation of protein kinase activity
0.41	GO:0007266	Rho protein signal transduction
0.40	GO:0043408	regulation of MAPK cascade
0.40	GO:0031098	stress-activated protein kinase signaling cascade
0.40	GO:0007346	regulation of mitotic cell cycle
0.39	GO:0016477	cell migration
0.39	GO:0030036	actin cytoskeleton organization
0.38	GO:1990872	negative regulation of sterol import by negative regulation of transcription from RNA polymerase II promoter

0.65	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0032555	purine ribonucleotide binding
0.42	GO:0048365	Rac GTPase binding
0.37	GO:0019901	protein kinase binding
0.37	GO:0030296	protein tyrosine kinase activator activity
0.36	GO:0005057	signal transducer activity, downstream of receptor
0.36	GO:0035173	histone kinase activity

0.37	GO:0120025	plasma membrane bounded cell projection
0.36	GO:0000131	incipient cellular bud site
0.35	GO:0030427	site of polarized growth
0.35	GO:0044463	cell projection part
0.35	GO:0015629	actin cytoskeleton
0.35	GO:0071521	Cdc42 GTPase complex
0.35	GO:0099513	polymeric cytoskeletal fiber
0.34	GO:0043204	perikaryon
0.34	GO:0005829	cytosol
0.34	GO:0070938	contractile ring

0.65

GO:0004674

tr|T1FYD4|T1FYD4_HELRO
Uncharacterized protein
Search

tr|T1FYD5|T1FYD5_HELRO
Uncharacterized protein
Search

tr|T1FYD6|T1FYD6_HELRO
Bestrophin homolog
Search

0.58	Bestrophin homolog

0.75	GO:1902476	chloride transmembrane transport
0.45	GO:0007601	visual perception
0.35	GO:0009992	cellular water homeostasis
0.34	GO:0006627	protein processing involved in protein targeting to mitochondrion
0.34	GO:0045332	phospholipid translocation

0.75	GO:0005254	chloride channel activity
0.35	GO:0005225	volume-sensitive anion channel activity
0.34	GO:0022839	ion gated channel activity
0.34	GO:0008381	mechanosensitive ion channel activity
0.34	GO:0004012	phospholipid-translocating ATPase activity
0.33	GO:0004222	metalloendopeptidase activity
0.33	GO:0016758	transferase activity, transferring hexosyl groups
0.33	GO:0000287	magnesium ion binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.79	GO:0034707	chloride channel complex
0.54	GO:0005886	plasma membrane
0.33	GO:0005759	mitochondrial matrix

0.34

GO:0004012

tr|T1FYD7|T1FYD7_HELRO
Uncharacterized protein
Search

0.94	Sodium bicarbonate transporter protein 11

0.69	GO:0015698	inorganic anion transport
0.42	GO:0035725	sodium ion transmembrane transport
0.42	GO:0051453	regulation of intracellular pH
0.41	GO:0006855	drug transmembrane transport
0.41	GO:0098656	anion transmembrane transport
0.40	GO:0015701	bicarbonate transport
0.40	GO:0042044	fluid transport
0.36	GO:1902600	hydrogen ion transmembrane transport
0.33	GO:0006526	arginine biosynthetic process
0.32	GO:0016310	phosphorylation

0.83	GO:0005452	inorganic anion exchanger activity
0.42	GO:0046715	active borate transmembrane transporter activity
0.41	GO:0015106	bicarbonate transmembrane transporter activity
0.41	GO:0015252	proton channel activity
0.39	GO:0005272	sodium channel activity
0.37	GO:0046983	protein dimerization activity
0.34	GO:0015301	anion:anion antiporter activity
0.33	GO:0004055	argininosuccinate synthase activity
0.33	GO:0015293	symporter activity
0.32	GO:0016301	kinase activity

0.38	GO:0005887	integral component of plasma membrane
0.34	GO:0016323	basolateral plasma membrane

0.33

EC:6.3.4.5

GO:0004055

tr|T1FYD8|T1FYD8_HELRO
Uncharacterized protein
Search

0.87	Mitochondrial ribosomal protein L13

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.35	GO:0019370	leukotriene biosynthetic process
0.34	GO:0035023	regulation of Rho protein signal transduction
0.34	GO:0006508	proteolysis
0.33	GO:0043624	cellular protein complex disassembly
0.33	GO:0060255	regulation of macromolecule metabolic process
0.33	GO:0031323	regulation of cellular metabolic process

0.64	GO:0003735	structural constituent of ribosome
0.43	GO:0003729	mRNA binding
0.41	GO:0004463	leukotriene-A4 hydrolase activity
0.34	GO:0008237	metallopeptidase activity
0.34	GO:0046872	metal ion binding
0.34	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.34	GO:0043565	sequence-specific DNA binding
0.34	GO:0016301	kinase activity
0.33	GO:0036402	proteasome-activating ATPase activity
0.33	GO:0016773	phosphotransferase activity, alcohol group as acceptor

0.61	GO:0005840	ribosome
0.45	GO:0005759	mitochondrial matrix
0.36	GO:0000324	fungal-type vacuole
0.33	GO:0005634	nucleus
0.33	GO:0031966	mitochondrial membrane
0.33	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.41	EC:3.3.2.6	GO:0004463
0.41	KEGG:R03057	GO:0004463

tr|T1FYD9|T1FYD9_HELRO
Uncharacterized protein
Search

0.48	GO:0006898	receptor-mediated endocytosis
0.42	GO:0007399	nervous system development
0.42	GO:0030154	cell differentiation
0.41	GO:1904447	folic acid import across plasma membrane
0.40	GO:0003223	ventricular compact myocardium morphogenesis
0.40	GO:0060982	coronary artery morphogenesis
0.40	GO:0061156	pulmonary artery morphogenesis
0.40	GO:0003139	secondary heart field specification
0.40	GO:0060068	vagina development
0.40	GO:0003148	outflow tract septum morphogenesis

0.66	GO:0005509	calcium ion binding
0.50	GO:0030228	lipoprotein particle receptor activity
0.36	GO:0004930	G-protein coupled receptor activity
0.35	GO:0004252	serine-type endopeptidase activity
0.35	GO:0005520	insulin-like growth factor binding
0.34	GO:0015248	sterol transporter activity
0.34	GO:0005102	receptor binding
0.34	GO:0017124	SH3 domain binding
0.33	GO:0042954	lipoprotein transporter activity
0.33	GO:0051087	chaperone binding

0.40	GO:0005903	brush border
0.39	GO:0016324	apical plasma membrane
0.39	GO:0030139	endocytic vesicle
0.39	GO:0043235	receptor complex
0.39	GO:0031253	cell projection membrane
0.39	GO:0009897	external side of plasma membrane
0.39	GO:0005905	clathrin-coated pit
0.39	GO:0030425	dendrite
0.39	GO:0030424	axon
0.38	GO:0005768	endosome

0.35

GO:0004252

tr|T1FYE0|T1FYE0_HELRO
Uncharacterized protein
Search

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.47	GO:0007210	serotonin receptor signaling pathway
0.42	GO:0016546	male courtship behavior, proboscis-mediated licking
0.42	GO:0016543	male courtship behavior, orientation prior to leg tapping and wing vibration
0.41	GO:0016545	male courtship behavior, veined wing vibration
0.40	GO:0060180	female mating behavior
0.40	GO:0019933	cAMP-mediated signaling
0.40	GO:0042310	vasoconstriction
0.40	GO:1901699	cellular response to nitrogen compound
0.39	GO:0007267	cell-cell signaling

0.72	GO:0004930	G-protein coupled receptor activity
0.52	GO:0030594	neurotransmitter receptor activity
0.47	GO:0099589	serotonin receptor activity
0.40	GO:0051378	serotonin binding
0.38	GO:0051380	norepinephrine binding
0.38	GO:0051379	epinephrine binding
0.36	GO:0000703	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
0.35	GO:0004844	uracil DNA N-glycosylase activity
0.35	GO:0032795	heterotrimeric G-protein binding
0.35	GO:0004715	non-membrane spanning protein tyrosine kinase activity

0.44	GO:0005887	integral component of plasma membrane
0.35	GO:0030286	dynein complex
0.34	GO:0031981	nuclear lumen
0.31	GO:0005737	cytoplasm

0.35

EC:3.2.2

GO:0004844

tr|T1FYE1|T1FYE1_HELRO
Uncharacterized protein
Search

EAPP

0.96	E2F-associated phosphoprotein isoform X2

0.84	GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter
0.78	GO:0008284	positive regulation of cell proliferation
0.77	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
0.35	GO:0016310	phosphorylation
0.35	GO:0046031	ADP metabolic process
0.35	GO:0006090	pyruvate metabolic process
0.34	GO:0016052	carbohydrate catabolic process
0.34	GO:0019362	pyridine nucleotide metabolic process
0.34	GO:0036211	protein modification process
0.34	GO:0046034	ATP metabolic process

0.36	GO:0004743	pyruvate kinase activity
0.35	GO:0030955	potassium ion binding
0.35	GO:0016301	kinase activity
0.34	GO:0000287	magnesium ion binding
0.34	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005634	nucleus
0.35	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.36

EC:2.7.1.40

GO:0004743

tr|T1FYE2|T1FYE2_HELRO
Uncharacterized protein
Search

0.83	Neuferricinlike [Saccoglossus kowalevskii]

0.59	GO:0016573	histone acetylation
0.50	GO:0007399	nervous system development
0.48	GO:0010720	positive regulation of cell development
0.48	GO:0051962	positive regulation of nervous system development
0.46	GO:1903506	regulation of nucleic acid-templated transcription
0.46	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.46	GO:0010468	regulation of gene expression
0.45	GO:0030154	cell differentiation

0.60	GO:0004402	histone acetyltransferase activity
0.58	GO:0003712	transcription cofactor activity
0.50	GO:0008270	zinc ion binding
0.49	GO:0020037	heme binding

0.49	GO:0005634	nucleus
0.47	GO:0012505	endomembrane system
0.46	GO:0005576	extracellular region
0.30	GO:0016020	membrane

0.60

GO:0004402

tr|T1FYE3|T1FYE3_HELRO
Uncharacterized protein
Search

0.74	Interferon regulatory factor 1

0.71	GO:0008285	negative regulation of cell proliferation
0.70	GO:0006915	apoptotic process
0.65	GO:0050776	regulation of immune response
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.54	GO:0006351	transcription, DNA-templated
0.39	GO:1902037	negative regulation of hematopoietic stem cell differentiation
0.38	GO:0045580	regulation of T cell differentiation
0.37	GO:0009615	response to virus

0.76	GO:0044212	transcription regulatory region DNA binding
0.60	GO:0003700	DNA binding transcription factor activity

0.56

GO:0005634

nucleus

tr|T1FYE4|T1FYE4_HELRO
Uncharacterized protein
Search

0.81	Potassium voltage-gated channel protein Shaker

0.77	GO:0051260	protein homooligomerization
0.77	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.46	GO:0001508	action potential
0.44	GO:0099624	atrial cardiac muscle cell membrane repolarization
0.44	GO:0086028	bundle of His cell to Purkinje myocyte signaling
0.44	GO:0086018	SA node cell to atrial cardiac muscle cell signaling
0.43	GO:0060081	membrane hyperpolarization
0.43	GO:0086026	atrial cardiac muscle cell to AV node cell signaling
0.43	GO:0007637	proboscis extension reflex

0.78	GO:0005249	voltage-gated potassium channel activity
0.43	GO:0019870	potassium channel inhibitor activity
0.43	GO:0051393	alpha-actinin binding
0.43	GO:0097110	scaffold protein binding
0.41	GO:0019901	protein kinase binding
0.39	GO:0030955	potassium ion binding
0.34	GO:0005102	receptor binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.42	GO:0014704	intercalated disc
0.41	GO:0098857	membrane microdomain
0.37	GO:0046691	intracellular canaliculus
0.35	GO:0030018	Z disc
0.35	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0005794	Golgi apparatus
0.34	GO:0005783	endoplasmic reticulum

tr|T1FYE5|T1FYE5_HELRO
Uncharacterized protein
Search

KLHDC4

0.82	Kelch domain-containing protein 4

0.41

GO:0006338

chromatin remodeling

0.49	GO:0005515	protein binding
0.40	GO:0003682	chromatin binding

0.42	GO:0016586	RSC-type complex
0.30	GO:0044425	membrane part

tr|T1FYE6|T1FYE6_HELRO
Uncharacterized protein
Search

tr|T1FYE7|T1FYE7_HELRO
Uncharacterized protein
Search

0.86	V-ets erythroblastosis virus E26 oncoprotein-like protein 1 (Fragment)

0.56	GO:0030578	PML body organization
0.56	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell
0.55	GO:0061614	pri-miRNA transcription by RNA polymerase II
0.55	GO:0045648	positive regulation of erythrocyte differentiation
0.54	GO:2001141	regulation of RNA biosynthetic process
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.54	GO:0043536	positive regulation of blood vessel endothelial cell migration
0.52	GO:0050729	positive regulation of inflammatory response
0.52	GO:0045766	positive regulation of angiogenesis

0.65	GO:0043565	sequence-specific DNA binding
0.58	GO:0003700	DNA binding transcription factor activity
0.50	GO:0001012	RNA polymerase II regulatory region DNA binding
0.48	GO:0042802	identical protein binding
0.48	GO:0003690	double-stranded DNA binding
0.41	GO:0035035	histone acetyltransferase binding
0.34	GO:0008134	transcription factor binding

0.61	GO:0005634	nucleus
0.48	GO:0005667	transcription factor complex
0.45	GO:0043233	organelle lumen
0.41	GO:0044446	intracellular organelle part
0.33	GO:0005737	cytoplasm

tr|T1FYE8|T1FYE8_HELRO
Bestrophin homolog
Search

0.63	Bestrophin

0.75	GO:1902476	chloride transmembrane transport
0.51	GO:0007601	visual perception
0.44	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay
0.44	GO:0070481	nuclear-transcribed mRNA catabolic process, non-stop decay
0.44	GO:0071025	RNA surveillance
0.36	GO:0050962	detection of light stimulus involved in sensory perception
0.36	GO:0051924	regulation of calcium ion transport
0.35	GO:0009584	detection of visible light
0.35	GO:0030321	transepithelial chloride transport
0.33	GO:0000398	mRNA splicing, via spliceosome

0.75	GO:0005254	chloride channel activity
0.34	GO:0042802	identical protein binding
0.32	GO:0016887	ATPase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003723	RNA binding
0.32	GO:0046872	metal ion binding

0.78	GO:0034707	chloride channel complex
0.53	GO:0005886	plasma membrane
0.33	GO:0005634	nucleus
0.32	GO:0043234	protein complex
0.32	GO:0044446	intracellular organelle part

0.32

GO:0016887

tr|T1FYE9|T1FYE9_HELRO
Histone deacetylase
Search

HDAC3

0.51	Histone deacetylase

0.80	GO:0016575	histone deacetylation
0.56	GO:0006351	transcription, DNA-templated
0.55	GO:2001141	regulation of RNA biosynthetic process
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.54	GO:0071498	cellular response to fluid shear stress
0.53	GO:0051253	negative regulation of RNA metabolic process
0.53	GO:0010558	negative regulation of macromolecule biosynthetic process
0.53	GO:0031327	negative regulation of cellular biosynthetic process
0.53	GO:0042993	positive regulation of transcription factor import into nucleus

0.81	GO:0004407	histone deacetylase activity
0.75	GO:0034979	NAD-dependent protein deacetylase activity
0.59	GO:0003714	transcription corepressor activity
0.53	GO:0051059	NF-kappaB binding
0.53	GO:0046872	metal ion binding
0.52	GO:0042826	histone deacetylase binding
0.51	GO:0030332	cyclin binding
0.50	GO:0003682	chromatin binding
0.35	GO:0019904	protein domain specific binding
0.34	GO:0070491	repressing transcription factor binding

0.59	GO:0005634	nucleus
0.51	GO:0017053	transcriptional repressor complex
0.50	GO:0005876	spindle microtubule
0.46	GO:0005794	Golgi apparatus
0.45	GO:0005829	cytosol
0.45	GO:0070013	intracellular organelle lumen
0.40	GO:0005886	plasma membrane
0.34	GO:1902494	catalytic complex
0.33	GO:0000785	chromatin
0.30	GO:0016021	integral component of membrane

0.81

EC:3.5.1.98

GO:0004407

tr|T1FYF0|T1FYF0_HELRO
Uncharacterized protein
Search

WDTC1

0.95	WD and tetratricopeptide repeats protein 1

0.85	GO:0035264	multicellular organism growth
0.84	GO:0045717	negative regulation of fatty acid biosynthetic process
0.84	GO:0032869	cellular response to insulin stimulus
0.82	GO:0008361	regulation of cell size
0.78	GO:0000122	negative regulation of transcription by RNA polymerase II
0.75	GO:0001701	in utero embryonic development
0.73	GO:0055082	cellular chemical homeostasis
0.72	GO:0043086	negative regulation of catalytic activity
0.71	GO:0006006	glucose metabolic process
0.41	GO:0016567	protein ubiquitination

0.84	GO:0042826	histone deacetylase binding
0.80	GO:0042393	histone binding
0.74	GO:0004857	enzyme inhibitor activity
0.33	GO:0003677	DNA binding

0.68	GO:0005829	cytosol
0.61	GO:0005634	nucleus
0.37	GO:0031974	membrane-enclosed lumen
0.35	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

tr|T1FYF1|T1FYF1_HELRO
Uncharacterized protein
Search

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.46	GO:0050775	positive regulation of dendrite morphogenesis
0.44	GO:0016358	dendrite development
0.41	GO:0097150	neuronal stem cell population maintenance
0.41	GO:0048013	ephrin receptor signaling pathway
0.40	GO:1902680	positive regulation of RNA biosynthetic process
0.40	GO:0010628	positive regulation of gene expression
0.39	GO:0000226	microtubule cytoskeleton organization
0.39	GO:0000902	cell morphogenesis
0.38	GO:0042493	response to drug

0.79	GO:0003713	transcription coactivator activity
0.34	GO:0005515	protein binding
0.34	GO:0032550	purine ribonucleoside binding
0.34	GO:0032561	guanyl ribonucleotide binding
0.33	GO:0003924	GTPase activity
0.33	GO:0003700	DNA binding transcription factor activity
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0000287	magnesium ion binding
0.32	GO:0003677	DNA binding

0.45	GO:0070603	SWI/SNF superfamily-type complex
0.45	GO:0097458	neuron part
0.44	GO:0000780	condensed nuclear chromosome, centromeric region
0.43	GO:0000776	kinetochore
0.40	GO:0005881	cytoplasmic microtubule
0.40	GO:0005829	cytosol
0.36	GO:0016604	nuclear body
0.30	GO:0016021	integral component of membrane

tr|T1FYF2|T1FYF2_HELRO
Uncharacterized protein
Search

0.54	GO:0055085	transmembrane transport
0.54	GO:0006811	ion transport
0.40	GO:0071702	organic substance transport
0.36	GO:0007588	excretion
0.36	GO:1901998	toxin transport
0.35	GO:0010876	lipid localization
0.35	GO:0070327	thyroid hormone transport
0.34	GO:0042886	amide transport

0.55

GO:0005215

transporter activity

0.51	GO:0005886	plasma membrane
0.33	GO:0043229	intracellular organelle
0.30	GO:0016021	integral component of membrane

tr|T1FYF3|T1FYF3_HELRO
Uncharacterized protein
Search

tr|T1FYF4|T1FYF4_HELRO
Uncharacterized protein
Search

AADAT

0.67	Aminoadipate aminotransferase

0.50	GO:0097052	L-kynurenine metabolic process
0.50	GO:0006103	2-oxoglutarate metabolic process
0.49	GO:0009058	biosynthetic process
0.47	GO:0006536	glutamate metabolic process
0.35	GO:0033512	L-lysine catabolic process to acetyl-CoA via saccharopine
0.34	GO:0019441	tryptophan catabolic process to kynurenine

0.67	GO:0030170	pyridoxal phosphate binding
0.59	GO:0008483	transaminase activity
0.47	GO:0042803	protein homodimerization activity

0.41	GO:0005739	mitochondrion
0.33	GO:0070013	intracellular organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.59

EC:2.6.1

GO:0008483

tr|T1FYF5|T1FYF5_HELRO
Uncharacterized protein
Search

0.62	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.56	GO:0006913	nucleocytoplasmic transport
0.47	GO:0045727	positive regulation of translation
0.38	GO:0006986	response to unfolded protein
0.34	GO:0051028	mRNA transport

0.51	GO:0003676	nucleic acid binding
0.35	GO:0005487	structural constituent of nuclear pore
0.33	GO:0005515	protein binding
0.30	GO:0003824	catalytic activity

0.50	GO:0035145	exon-exon junction complex
0.44	GO:0005829	cytosol

tr|T1FYF6|T1FYF6_HELRO
Uncharacterized protein
Search

tr|T1FYF7|T1FYF7_HELRO
Uncharacterized protein
Search

0.30	Transmembrane protein 198-B

0.56	GO:0006367	transcription initiation from RNA polymerase II promoter
0.52	GO:0006289	nucleotide-excision repair
0.51	GO:0032392	DNA geometric change
0.36	GO:0006508	proteolysis

0.52	GO:0004003	ATP-dependent DNA helicase activity
0.43	GO:0032559	adenyl ribonucleotide binding
0.43	GO:0003677	DNA binding
0.42	GO:0008144	drug binding
0.42	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0004197	cysteine-type endopeptidase activity

0.30

GO:0016020

membrane

0.39

EC:3.4.22

GO:0004197

tr|T1FYF8|T1FYF8_HELRO
Uncharacterized protein
Search

0.45	GO:0097236	positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation
0.35	GO:0006366	transcription by RNA polymerase II
0.34	GO:0007275	multicellular organism development
0.33	GO:0007165	signal transduction

0.51	GO:0003676	nucleic acid binding
0.42	GO:0008270	zinc ion binding
0.40	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.34	GO:0030170	pyridoxal phosphate binding

0.41

GO:0005634

nucleus

tr|T1FYF9|T1FYF9_HELRO
Uncharacterized protein
Search

0.53	Carboxyterminal kinesin 2like [Aplysia californica] (Fragment)

0.74	GO:0007018	microtubule-based movement
0.43	GO:0007080	mitotic metaphase plate congression
0.43	GO:0007052	mitotic spindle organization
0.41	GO:0051225	spindle assembly
0.39	GO:0000742	karyogamy involved in conjugation with cellular fusion
0.39	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity
0.39	GO:0051231	spindle elongation
0.39	GO:0030705	cytoskeleton-dependent intracellular transport
0.38	GO:0007097	nuclear migration
0.38	GO:0031122	cytoplasmic microtubule organization

0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0016887	ATPase activity
0.36	GO:0004713	protein tyrosine kinase activity

0.68	GO:0005874	microtubule
0.42	GO:0005871	kinesin complex
0.39	GO:0005819	spindle
0.39	GO:0030981	cortical microtubule cytoskeleton
0.38	GO:0000778	condensed nuclear chromosome kinetochore
0.37	GO:0005769	early endosome
0.36	GO:0005815	microtubule organizing center
0.34	GO:0030496	midbody
0.34	GO:0030139	endocytic vesicle
0.30	GO:0031224	intrinsic component of membrane

0.39

GO:0016887

tr|T1FYG0|T1FYG0_HELRO
Uncharacterized protein
Search

MYORG

0.72	Myogenesis-regulating glycosidase

0.60	GO:0005975	carbohydrate metabolic process
0.49	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
0.48	GO:0048741	skeletal muscle fiber development
0.47	GO:0051897	positive regulation of protein kinase B signaling
0.32	GO:0055114	oxidation-reduction process
0.30	GO:0044237	cellular metabolic process

0.66	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.33	GO:0005515	protein binding
0.32	GO:0016491	oxidoreductase activity

0.45	GO:0031965	nuclear membrane
0.43	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

0.66

GO:0004553

tr|T1FYG1|T1FYG1_HELRO
Uncharacterized protein
Search

0.43	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.43	GO:1903506	regulation of nucleic acid-templated transcription
0.43	GO:0010468	regulation of gene expression

0.47	GO:0043565	sequence-specific DNA binding
0.46	GO:0003700	DNA binding transcription factor activity

0.30

GO:0044425

membrane part

tr|T1FYG2|T1FYG2_HELRO
Uncharacterized protein
Search

0.82	Transcriptional repressor protein YY1

0.42	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II
0.42	GO:0032688	negative regulation of interferon-beta production
0.42	GO:0010225	response to UV-C
0.41	GO:0034644	cellular response to UV
0.41	GO:0048593	camera-type eye morphogenesis
0.40	GO:0010628	positive regulation of gene expression
0.40	GO:0009952	anterior/posterior pattern specification
0.40	GO:0007283	spermatogenesis
0.39	GO:0000724	double-strand break repair via homologous recombination
0.39	GO:0006403	RNA localization

0.51	GO:0003676	nucleic acid binding
0.41	GO:0046332	SMAD binding
0.41	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.36	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.33	GO:0004222	metalloendopeptidase activity

0.40	GO:0031519	PcG protein complex
0.40	GO:0031011	Ino80 complex
0.39	GO:0005667	transcription factor complex
0.30	GO:0016020	membrane

0.36

GO:0036459

tr|T1FYG3|T1FYG3_HELRO
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit
Search

0.43	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit

0.71

GO:0006099

tricarboxylic acid cycle

0.54

GO:0046872

metal ion binding

0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane
0.30	GO:0044425	membrane part

tr|T1FYG4|T1FYG4_HELRO
Uncharacterized protein
Search

0.43	GO:0006357	regulation of transcription by RNA polymerase II
0.41	GO:0008643	carbohydrate transport
0.30	GO:0008152	metabolic process

0.51	GO:0003676	nucleic acid binding
0.36	GO:0000062	fatty-acyl-CoA binding
0.34	GO:0016853	isomerase activity

0.41	GO:0005634	nucleus
0.35	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.34

GO:0016853

tr|T1FYG5|T1FYG5_HELRO
Uncharacterized protein
Search

0.51	Ubiquitin carboxyl-terminal hydrolase CYLD

0.73	GO:0016579	protein deubiquitination
0.52	GO:0006511	ubiquitin-dependent protein catabolic process
0.45	GO:0055090	acylglycerol homeostasis
0.44	GO:0006952	defense response
0.44	GO:0008340	determination of adult lifespan
0.44	GO:0050776	regulation of immune response
0.44	GO:0031098	stress-activated protein kinase signaling cascade
0.44	GO:1901026	ripoptosome assembly involved in necroptotic process
0.43	GO:0042347	negative regulation of NF-kappaB import into nucleus
0.43	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway

0.74	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.49	GO:0061578	Lys63-specific deubiquitinase activity
0.47	GO:0061815	ubiquitinyl hydrolase activity, acting on linear ubiquitin
0.43	GO:0070064	proline-rich region binding
0.42	GO:1990380	Lys48-specific deubiquitinase activity
0.41	GO:0019901	protein kinase binding
0.38	GO:0003735	structural constituent of ribosome
0.37	GO:0008270	zinc ion binding
0.34	GO:0004435	phosphatidylinositol phospholipase C activity
0.33	GO:0005509	calcium ion binding

0.43	GO:0097542	ciliary tip
0.42	GO:0005881	cytoplasmic microtubule
0.42	GO:0030496	midbody
0.41	GO:0036064	ciliary basal body
0.41	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.41	GO:0005829	cytosol
0.41	GO:0005813	centrosome
0.40	GO:0005819	spindle
0.37	GO:0005840	ribosome
0.36	GO:0005680	anaphase-promoting complex

0.74	EC:3.4.19.12	GO:0036459
0.34	KEGG:R03435	GO:0004435

tr|T1FYG6|T1FYG6_HELRO
Uncharacterized protein
Search

0.85	Chronic lymphocytic leukemia deletion region gene 6 protein homolog [Bombus terrestris]

tr|T1FYG7|T1FYG7_HELRO
Uncharacterized protein
Search

RWDD4

0.96	RWD domain-containing protein 4

0.39	GO:0032559	adenyl ribonucleotide binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0008144	drug binding

tr|T1FYG8|T1FYG8_HELRO
Uncharacterized protein
Search

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:0030097	hemopoiesis
0.45	GO:1903706	regulation of hemopoiesis
0.43	GO:0045597	positive regulation of cell differentiation
0.43	GO:0051240	positive regulation of multicellular organismal process
0.43	GO:0002684	positive regulation of immune system process
0.42	GO:0034101	erythrocyte homeostasis
0.42	GO:0030154	cell differentiation

0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.46	GO:0044212	transcription regulatory region DNA binding
0.44	GO:0003690	double-stranded DNA binding
0.43	GO:0001085	RNA polymerase II transcription factor binding
0.41	GO:0003682	chromatin binding
0.38	GO:0070742	C2H2 zinc finger domain binding
0.35	GO:0008301	DNA binding, bending
0.35	GO:0002039	p53 binding

0.45	GO:0005634	nucleus
0.41	GO:0005667	transcription factor complex
0.37	GO:0017053	transcriptional repressor complex
0.35	GO:0032993	protein-DNA complex
0.30	GO:0044425	membrane part

tr|T1FYG9|T1FYG9_HELRO
Uncharacterized protein
Search

0.59

GO:0003723

RNA binding

0.34

GO:0005737

cytoplasm

tr|T1FYH0|T1FYH0_HELRO
Uncharacterized protein
Search

0.62	Survival of motor neuron-related-splicing factor 30

0.70

GO:0006397

mRNA processing

0.59

GO:0003723

RNA binding

0.61	GO:0005634	nucleus
0.49	GO:0005737	cytoplasm

tr|T1FYH1|T1FYH1_HELRO
Uncharacterized protein
Search

SLC47A1

0.55	Multidrug and toxin extrusion protein 1

0.72	GO:0006855	drug transmembrane transport
0.43	GO:0015695	organic cation transport
0.39	GO:1902600	hydrogen ion transmembrane transport
0.35	GO:0046618	drug export

0.72	GO:0015238	drug transmembrane transporter activity
0.72	GO:0015297	antiporter activity
0.39	GO:0015078	hydrogen ion transmembrane transporter activity
0.33	GO:0016846	carbon-sulfur lyase activity

0.42	GO:0031982	vesicle
0.35	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

0.33

EC:4.4

GO:0016846

tr|T1FYH2|T1FYH2_HELRO
Uncharacterized protein
Search

0.37	Short transient receptor potential channel 3

0.77	GO:0070588	calcium ion transmembrane transport
0.46	GO:1903244	positive regulation of cardiac muscle hypertrophy in response to stress
0.45	GO:0051480	regulation of cytosolic calcium ion concentration
0.44	GO:0033198	response to ATP
0.44	GO:0051928	positive regulation of calcium ion transport
0.44	GO:0051592	response to calcium ion
0.44	GO:0010522	regulation of calcium ion transport into cytosol
0.43	GO:0032846	positive regulation of homeostatic process
0.42	GO:0006828	manganese ion transport
0.41	GO:0007338	single fertilization

0.80	GO:0005262	calcium channel activity
0.44	GO:0070679	inositol 1,4,5 trisphosphate binding
0.33	GO:0046983	protein dimerization activity
0.33	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.41

GO:0005887

integral component of plasma membrane

tr|T1FYH3|T1FYH3_HELRO
POU domain protein
Search

0.60	Class IV POU domain protein 1 (Fragment)

0.57	GO:0006351	transcription, DNA-templated
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.52	GO:0007605	sensory perception of sound
0.51	GO:0048513	animal organ development
0.50	GO:1902870	negative regulation of amacrine cell differentiation
0.49	GO:0090259	regulation of retinal ganglion cell axon guidance
0.49	GO:0031290	retinal ganglion cell axon guidance
0.48	GO:0050885	neuromuscular process controlling balance

0.64	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.47	GO:1990841	promoter-specific chromatin binding
0.46	GO:0001012	RNA polymerase II regulatory region DNA binding
0.46	GO:0003714	transcription corepressor activity
0.44	GO:0003690	double-stranded DNA binding
0.36	GO:0003713	transcription coactivator activity
0.32	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.42	GO:0070013	intracellular organelle lumen
0.39	GO:0044446	intracellular organelle part
0.36	GO:0005737	cytoplasm
0.33	GO:0005886	plasma membrane

tr|T1FYH4|T1FYH4_HELRO
Uncharacterized protein
Search

0.72	GO:0060693	regulation of branching involved in salivary gland morphogenesis
0.40	GO:0016573	histone acetylation
0.38	GO:0007275	multicellular organism development
0.37	GO:0006289	nucleotide-excision repair

0.41	GO:0004402	histone acetyltransferase activity
0.37	GO:0003684	damaged DNA binding
0.35	GO:0046872	metal ion binding

0.52	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.41

GO:0004402

tr|T1FYH5|T1FYH5_HELRO
Uncharacterized protein
Search

0.58	GO:0006508	proteolysis
0.37	GO:0071432	peptide mating pheromone maturation involved in conjugation with cellular fusion

0.66	GO:0004222	metalloendopeptidase activity
0.54	GO:0046872	metal ion binding

0.35

GO:0019898

extrinsic component of membrane

0.66

GO:0004222

tr|T1FYH6|T1FYH6_HELRO
Adenylyl cyclase-associated protein
Search

CAP1

0.74	Adenylyl cyclase-associated protein 1

0.71	GO:0007010	cytoskeleton organization
0.61	GO:0030029	actin filament-based process
0.48	GO:0001667	ameboidal-type cell migration
0.48	GO:0000902	cell morphogenesis
0.46	GO:0045761	regulation of adenylate cyclase activity
0.45	GO:0007163	establishment or maintenance of cell polarity
0.44	GO:0006898	receptor-mediated endocytosis
0.43	GO:0097435	supramolecular fiber organization
0.39	GO:0007165	signal transduction
0.36	GO:0001756	somitogenesis

0.74	GO:0003779	actin binding
0.48	GO:0008179	adenylate cyclase binding
0.35	GO:0042802	identical protein binding
0.33	GO:0003735	structural constituent of ribosome

0.51	GO:0030864	cortical actin cytoskeleton
0.45	GO:0005615	extracellular space
0.36	GO:0014069	postsynaptic density
0.35	GO:0005925	focal adhesion
0.35	GO:1903561	extracellular vesicle
0.35	GO:0005886	plasma membrane
0.35	GO:0035578	azurophil granule lumen
0.33	GO:0015934	large ribosomal subunit
0.33	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

tr|T1FYH7|T1FYH7_HELRO
Uncharacterized protein
Search

0.95	Ankyrin repeat and death domain containing 1B

0.59	GO:0007165	signal transduction
0.36	GO:0050960	detection of temperature stimulus involved in thermoception
0.35	GO:0050974	detection of mechanical stimulus involved in sensory perception
0.35	GO:0070542	response to fatty acid
0.34	GO:0009116	nucleoside metabolic process
0.34	GO:0009593	detection of chemical stimulus
0.34	GO:0006508	proteolysis
0.33	GO:0034220	ion transmembrane transport
0.33	GO:2000031	regulation of salicylic acid mediated signaling pathway
0.33	GO:0071446	cellular response to salicylic acid stimulus

0.35	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.34	GO:0015276	ligand-gated ion channel activity
0.34	GO:0004175	endopeptidase activity
0.34	GO:0017171	serine hydrolase activity
0.33	GO:0003950	NAD+ ADP-ribosyltransferase activity
0.32	GO:0070001	aspartic-type peptidase activity

0.30

GO:0016020

membrane

0.35

EC:1.3.1.74

GO:0032440

tr|T1FYH8|T1FYH8_HELRO
Uncharacterized protein
Search

0.82	Neural-specific syntaxin-binding protein 1

0.80	GO:0006904	vesicle docking involved in exocytosis
0.43	GO:0007317	regulation of pole plasm oskar mRNA localization
0.42	GO:1900006	positive regulation of dendrite development
0.42	GO:0030707	ovarian follicle cell development
0.41	GO:0099643	signal release from synapse
0.41	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.41	GO:0000281	mitotic cytokinesis
0.40	GO:0009416	response to light stimulus
0.40	GO:0006836	neurotransmitter transport
0.39	GO:0001505	regulation of neurotransmitter levels

0.34	GO:0000149	SNARE binding
0.34	GO:0004055	argininosuccinate synthase activity
0.33	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003723	RNA binding

0.42	GO:0043195	terminal bouton
0.40	GO:0019898	extrinsic component of membrane
0.39	GO:0005829	cytosol
0.33	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.34

EC:6.3.4.5

GO:0004055

tr|T1FYH9|T1FYH9_HELRO
Uncharacterized protein
Search

HTATIP2

0.94	HIV-1 Tat interactive protein 2

0.70	GO:0045765	regulation of angiogenesis
0.65	GO:0051170	nuclear import
0.45	GO:0055114	oxidation-reduction process

0.56	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.55	GO:0051287	NAD binding

0.66	GO:0005635	nuclear envelope
0.60	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.56

EC:1.2.1

GO:0016620

tr|T1FYI0|T1FYI0_HELRO
Uncharacterized protein
Search

tr|T1FYI1|T1FYI1_HELRO
Uncharacterized protein
Search

RPUSD1

0.91	RNA pseudouridylate synthase domain-containing protein 1

0.72	GO:0001522	pseudouridine synthesis
0.41	GO:0000154	rRNA modification
0.40	GO:0006400	tRNA modification

0.72	GO:0009982	pseudouridine synthase activity
0.59	GO:0003723	RNA binding
0.42	GO:0019239	deaminase activity

0.30

GO:0031224

intrinsic component of membrane

0.72

EC:5.4.99.12

GO:0009982

tr|T1FYI2|T1FYI2_HELRO
Uncharacterized protein
Search

TIMM44

0.75	Mitochondrial import inner membrane translocase subunit TIM44

0.80	GO:0030150	protein import into mitochondrial matrix
0.37	GO:0071456	cellular response to hypoxia
0.36	GO:1905242	response to 3,3',5-triiodo-L-thyronine
0.35	GO:0055007	cardiac muscle cell differentiation
0.34	GO:0016567	protein ubiquitination
0.33	GO:0006417	regulation of translation
0.33	GO:0006897	endocytosis

0.76	GO:0051087	chaperone binding
0.34	GO:0043130	ubiquitin binding
0.34	GO:0004842	ubiquitin-protein transferase activity
0.33	GO:0035091	phosphatidylinositol binding
0.33	GO:0003723	RNA binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0016874	ligase activity

0.57	GO:0031966	mitochondrial membrane
0.57	GO:0019866	organelle inner membrane
0.38	GO:0005759	mitochondrial matrix
0.34	GO:0030904	retromer complex
0.30	GO:0031224	intrinsic component of membrane

0.33	EC:6	GO:0016874
0.34	KEGG:R03876	GO:0004842

tr|T1FYI3|T1FYI3_HELRO
Uncharacterized protein
Search

0.82	GO:0030010	establishment of cell polarity
0.76	GO:0000226	microtubule cytoskeleton organization
0.63	GO:0006468	protein phosphorylation
0.44	GO:0035330	regulation of hippo signaling
0.44	GO:0030860	regulation of polarized epithelial cell differentiation
0.44	GO:0030709	border follicle cell delamination
0.43	GO:0007318	pole plasm protein localization
0.43	GO:0001737	establishment of imaginal disc-derived wing hair orientation
0.43	GO:0007317	regulation of pole plasm oskar mRNA localization
0.43	GO:0007294	germarium-derived oocyte fate determination

0.70	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.44	GO:0050321	tau-protein kinase activity
0.34	GO:0070300	phosphatidic acid binding
0.34	GO:0001786	phosphatidylserine binding
0.34	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.34	GO:0003723	RNA binding

0.43	GO:0045172	germline ring canal
0.43	GO:0061174	type I terminal bouton
0.43	GO:0045169	fusome
0.42	GO:0031594	neuromuscular junction
0.41	GO:0016323	basolateral plasma membrane
0.40	GO:0005938	cell cortex
0.34	GO:0070062	extracellular exosome
0.33	GO:0015630	microtubule cytoskeleton
0.33	GO:0005829	cytosol
0.33	GO:0005694	chromosome

0.70

GO:0004674

tr|T1FYI4|T1FYI4_HELRO
Uncharacterized protein
Search

0.11	Notch homolog (Fragment)

0.58	GO:0007219	Notch signaling pathway
0.52	GO:0007275	multicellular organism development
0.51	GO:0030154	cell differentiation
0.49	GO:0050793	regulation of developmental process
0.44	GO:0035633	maintenance of permeability of blood-brain barrier
0.43	GO:0097150	neuronal stem cell population maintenance
0.43	GO:0048859	formation of anatomical boundary
0.42	GO:0060322	head development
0.42	GO:0043114	regulation of vascular permeability
0.42	GO:2001141	regulation of RNA biosynthetic process

0.69	GO:0005509	calcium ion binding
0.46	GO:0004872	receptor activity
0.36	GO:0005112	Notch binding
0.35	GO:0004252	serine-type endopeptidase activity
0.35	GO:0005201	extracellular matrix structural constituent
0.34	GO:0043236	laminin binding
0.34	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.34	GO:0004857	enzyme inhibitor activity
0.34	GO:0008061	chitin binding
0.33	GO:0061134	peptidase regulator activity

0.42	GO:0005576	extracellular region
0.33	GO:0005791	rough endoplasmic reticulum
0.33	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex
0.33	GO:0001669	acrosomal vesicle
0.33	GO:0001726	ruffle
0.33	GO:0030027	lamellipodium
0.33	GO:0016324	apical plasma membrane
0.33	GO:0005912	adherens junction
0.33	GO:0005634	nucleus
0.33	GO:0043235	receptor complex

0.35

GO:0004252

tr|T1FYI5|T1FYI5_HELRO
Uncharacterized protein
Search

0.58	Zinc finger MYM-type protein 1

0.36	GO:0006357	regulation of transcription by RNA polymerase II
0.35	GO:0007275	multicellular organism development
0.34	GO:0006796	phosphate-containing compound metabolic process
0.33	GO:0008299	isoprenoid biosynthetic process
0.33	GO:0072527	pyrimidine-containing compound metabolic process
0.33	GO:0006313	transposition, DNA-mediated
0.32	GO:0055086	nucleobase-containing small molecule metabolic process
0.32	GO:0019637	organophosphate metabolic process
0.32	GO:1901135	carbohydrate derivative metabolic process

0.68	GO:0046983	protein dimerization activity
0.37	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.34	GO:0003677	DNA binding
0.34	GO:0016301	kinase activity
0.34	GO:0019901	protein kinase binding
0.34	GO:0004170	dUTP diphosphatase activity
0.33	GO:0004803	transposase activity
0.33	GO:0008270	zinc ion binding

0.36	GO:0005654	nucleoplasm
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.34	EC:3.6.1.23	GO:0004170
0.34	KEGG:R02100	GO:0004170

tr|T1FYI6|T1FYI6_HELRO
Uncharacterized protein
Search

CG14806

0.84	Apoptogenic protein 1, mitochondrial

0.84	GO:0097193	intrinsic apoptotic signaling pathway
0.43	GO:0090200	positive regulation of release of cytochrome c from mitochondria
0.42	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.37	GO:0006400	tRNA modification

0.38	GO:0016763	transferase activity, transferring pentosyl groups
0.36	GO:0003777	microtubule motor activity

0.45	GO:0005622	intracellular
0.36	GO:0043227	membrane-bounded organelle
0.34	GO:0043234	protein complex
0.34	GO:0043228	non-membrane-bounded organelle
0.34	GO:0044422	organelle part

0.38

EC:2.4.2

GO:0016763

tr|T1FYI7|T1FYI7_HELRO
Probable methylthioribulose-1-phosphate dehydratase
Search

APIP

0.62	Methylthioribulose-1-phosphate dehydratase

0.77	GO:0019509	L-methionine salvage from methylthioadenosine
0.71	GO:0019284	L-methionine salvage from S-adenosylmethionine
0.58	GO:0006915	apoptotic process
0.55	GO:0070269	pyroptosis
0.52	GO:0051289	protein homotetramerization
0.50	GO:0070372	regulation of ERK1 and ERK2 cascade
0.49	GO:0043066	negative regulation of apoptotic process
0.33	GO:0006468	protein phosphorylation

0.78	GO:0046570	methylthioribulose 1-phosphate dehydratase activity
0.59	GO:0008270	zinc ion binding
0.47	GO:0042802	identical protein binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.49

GO:0005737

cytoplasm

0.78	EC:4.2.1.109	GO:0046570
0.78	KEGG:R07392	GO:0046570

tr|T1FYI8|T1FYI8_HELRO
Uncharacterized protein
Search

0.61	Potassium channel kcnq

0.73	GO:0071805	potassium ion transmembrane transport
0.49	GO:0060048	cardiac muscle contraction
0.49	GO:0001700	embryonic development via the syncytial blastoderm
0.49	GO:0002027	regulation of heart rate
0.33	GO:0045892	negative regulation of transcription, DNA-templated

0.78

GO:0005249

voltage-gated potassium channel activity

0.78	GO:0008076	voltage-gated potassium channel complex
0.33	GO:0005634	nucleus

tr|T1FYI9|T1FYI9_HELRO
Uncharacterized protein
Search

0.94	WD repeat-containing protein 25

0.53

GO:0005515

protein binding

tr|T1FYJ0|T1FYJ0_HELRO
Uncharacterized protein
Search

0.59	GO:0032259	methylation
0.50	GO:0033169	histone H3-K9 demethylation
0.39	GO:1903506	regulation of nucleic acid-templated transcription
0.39	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.39	GO:0010468	regulation of gene expression

0.59	GO:0008168	methyltransferase activity
0.50	GO:0032454	histone demethylase activity (H3-K9 specific)
0.48	GO:0031490	chromatin DNA binding
0.45	GO:0000976	transcription regulatory region sequence-specific DNA binding
0.38	GO:0008270	zinc ion binding

0.44	GO:0000785	chromatin
0.43	GO:0005634	nucleus
0.39	GO:0043233	organelle lumen

0.59

GO:0008168

tr|T1FYJ1|T1FYJ1_HELRO
Uncharacterized protein
Search

0.61	Rho GTPase activating protein 9

0.66	GO:0043547	positive regulation of GTPase activity
0.57	GO:0007165	signal transduction
0.46	GO:0006911	phagocytosis, engulfment
0.46	GO:0002011	morphogenesis of an epithelial sheet
0.46	GO:0051058	negative regulation of small GTPase mediated signal transduction
0.43	GO:0007015	actin filament organization
0.33	GO:0006898	receptor-mediated endocytosis

0.66	GO:0005096	GTPase activator activity
0.45	GO:0005543	phospholipid binding
0.34	GO:0017124	SH3 domain binding

0.47	GO:0001891	phagocytic cup
0.38	GO:0005829	cytosol
0.38	GO:0005654	nucleoplasm

tr|T1FYJ2|T1FYJ2_HELRO
Uncharacterized protein
Search

ICA1

0.69	Islet cell autoantigen 1

0.77	GO:0050796	regulation of insulin secretion
0.37	GO:0006836	neurotransmitter transport
0.35	GO:0043496	regulation of protein homodimerization activity
0.35	GO:0046928	regulation of neurotransmitter secretion

0.74

GO:0019904

protein domain specific binding

0.78	GO:0030667	secretory granule membrane
0.68	GO:0000139	Golgi membrane
0.54	GO:0030672	synaptic vesicle membrane
0.47	GO:0005829	cytosol
0.36	GO:0030054	cell junction
0.34	GO:0030425	dendrite
0.34	GO:0005795	Golgi stack
0.34	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0016021	integral component of membrane

tr|T1FYJ3|T1FYJ3_HELRO
Uncharacterized protein
Search

SELENBP1

0.77	Selenium-binding protein 1

0.38	GO:0015031	protein transport
0.36	GO:0050873	brown fat cell differentiation
0.34	GO:0007165	signal transduction

0.85	GO:0008430	selenium binding
0.34	GO:0005515	protein binding

0.50	GO:0001650	fibrillar center
0.39	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

tr|T1FYJ4|T1FYJ4_HELRO
Uncharacterized protein
Search

DYNLRB2

0.81	Dynein light chain roadblock

0.73	GO:0007018	microtubule-based movement
0.35	GO:0031503	protein complex localization
0.35	GO:0030705	cytoskeleton-dependent intracellular transport
0.35	GO:0060271	cilium assembly
0.34	GO:0006886	intracellular protein transport
0.34	GO:0007632	visual behavior

0.76	GO:0045505	dynein intermediate chain binding
0.64	GO:0003774	motor activity
0.32	GO:0003676	nucleic acid binding

0.82	GO:0005868	cytoplasmic dynein complex
0.65	GO:0005874	microtubule
0.50	GO:0036157	outer dynein arm
0.40	GO:0005813	centrosome
0.36	GO:0097542	ciliary tip
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

tr|T1FYJ5|T1FYJ5_HELRO
Uncharacterized protein
Search

RSPH1

0.55	Radial spoke head 1

0.45	GO:0035082	axoneme assembly
0.45	GO:0007283	spermatogenesis
0.44	GO:0007281	germ cell development
0.43	GO:0016310	phosphorylation
0.40	GO:0034968	histone lysine methylation
0.37	GO:0046488	phosphatidylinositol metabolic process
0.37	GO:0030258	lipid modification
0.36	GO:0051321	meiotic cell cycle
0.35	GO:0007275	multicellular organism development
0.35	GO:0007018	microtubule-based movement

0.44	GO:0016301	kinase activity
0.40	GO:0018024	histone-lysine N-methyltransferase activity
0.36	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0003777	microtubule motor activity
0.35	GO:0008017	microtubule binding
0.34	GO:0070001	aspartic-type peptidase activity
0.33	GO:0046914	transition metal ion binding

0.46	GO:0072687	meiotic spindle
0.45	GO:0031514	motile cilium
0.44	GO:0097223	sperm part
0.43	GO:0000794	condensed nuclear chromosome
0.38	GO:0044441	ciliary part
0.37	GO:0099513	polymeric cytoskeletal fiber
0.36	GO:0005737	cytoplasm
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0031224	intrinsic component of membrane

0.40

GO:0018024

tr|T1FYJ6|T1FYJ6_HELRO
Uncharacterized protein
Search

0.49	GO:0038084	vascular endothelial growth factor signaling pathway
0.48	GO:0071526	semaphorin-plexin signaling pathway
0.48	GO:0001525	angiogenesis
0.47	GO:0007411	axon guidance
0.45	GO:0006468	protein phosphorylation
0.44	GO:0007186	G-protein coupled receptor signaling pathway
0.43	GO:0006508	proteolysis

0.68	GO:0070492	oligosaccharide binding
0.49	GO:0005021	vascular endothelial growth factor-activated receptor activity
0.48	GO:0017154	semaphorin receptor activity
0.47	GO:0070001	aspartic-type peptidase activity
0.45	GO:0004175	endopeptidase activity
0.44	GO:0004930	G-protein coupled receptor activity
0.44	GO:0008270	zinc ion binding
0.41	GO:0032559	adenyl ribonucleotide binding
0.41	GO:0003676	nucleic acid binding
0.41	GO:0008144	drug binding

0.30

GO:0016020

membrane

tr|T1FYJ7|T1FYJ7_HELRO
Uncharacterized protein
Search

0.83

GO:0033227

dsRNA transport

0.35	GO:0005743	mitochondrial inner membrane
0.30	GO:0044425	membrane part

tr|T1FYJ8|T1FYJ8_HELRO
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Search

HIBCH

0.75	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

0.80	GO:0006574	valine catabolic process
0.35	GO:1903818	positive regulation of voltage-gated potassium channel activity
0.35	GO:0032222	regulation of synaptic transmission, cholinergic
0.34	GO:0045187	regulation of circadian sleep/wake cycle, sleep
0.34	GO:0030431	sleep
0.34	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly
0.34	GO:0048511	rhythmic process

0.81	GO:0003860	3-hydroxyisobutyryl-CoA hydrolase activity
0.35	GO:0034235	GPI anchor binding
0.34	GO:0016853	isomerase activity

0.59	GO:0005739	mitochondrion
0.36	GO:0070062	extracellular exosome
0.34	GO:0031225	anchored component of membrane
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.81

EC:3.1.2.4

GO:0003860

tr|T1FYJ9|T1FYJ9_HELRO
Uncharacterized protein
Search

0.81	GO:2000393	negative regulation of lamellipodium morphogenesis
0.79	GO:1900028	negative regulation of ruffle assembly
0.77	GO:0035413	positive regulation of catenin import into nucleus
0.76	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
0.76	GO:0035024	negative regulation of Rho protein signal transduction
0.75	GO:0046627	negative regulation of insulin receptor signaling pathway
0.74	GO:0090303	positive regulation of wound healing
0.73	GO:0010977	negative regulation of neuron projection development
0.72	GO:0030177	positive regulation of Wnt signaling pathway
0.71	GO:0030336	negative regulation of cell migration

0.72	GO:0008013	beta-catenin binding
0.39	GO:0031418	L-ascorbic acid binding
0.38	GO:0005085	guanyl-nucleotide exchange factor activity
0.38	GO:0003777	microtubule motor activity
0.38	GO:0008017	microtubule binding
0.38	GO:0003779	actin binding
0.37	GO:0016491	oxidoreductase activity
0.37	GO:0008270	zinc ion binding
0.36	GO:0005506	iron ion binding
0.35	GO:0003676	nucleic acid binding

0.73	GO:0032587	ruffle membrane
0.42	GO:0005634	nucleus
0.39	GO:0005737	cytoplasm
0.38	GO:0016459	myosin complex
0.35	GO:0000151	ubiquitin ligase complex
0.35	GO:0097708	intracellular vesicle
0.34	GO:0012505	endomembrane system
0.30	GO:0016021	integral component of membrane

0.37

GO:0016491

tr|T1FYK0|T1FYK0_HELRO
Uncharacterized protein
Search

0.52	Voltage-dependent T-type calcium channel subunit alpha

0.68	GO:0070588	calcium ion transmembrane transport
0.66	GO:0034765	regulation of ion transmembrane transport
0.62	GO:0051899	membrane depolarization
0.60	GO:0045760	positive regulation of action potential
0.60	GO:0043051	regulation of pharyngeal pumping
0.49	GO:0019228	neuronal action potential
0.46	GO:0070509	calcium ion import
0.45	GO:0035725	sodium ion transmembrane transport

0.72	GO:0005245	voltage-gated calcium channel activity
0.48	GO:0005248	voltage-gated sodium channel activity

0.71

GO:0005891

voltage-gated calcium channel complex

tr|T1FYK1|T1FYK1_HELRO
Uncharacterized protein
Search

0.56	GO:0019372	lipoxygenase pathway
0.55	GO:0035963	cellular response to interleukin-13
0.54	GO:0019369	arachidonic acid metabolic process
0.54	GO:2001303	lipoxin A4 biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.52	GO:0071277	cellular response to calcium ion
0.52	GO:1901074	regulation of engulfment of apoptotic cell
0.52	GO:0010811	positive regulation of cell-substrate adhesion
0.51	GO:0035358	regulation of peroxisome proliferator activated receptor signaling pathway
0.51	GO:0070374	positive regulation of ERK1 and ERK2 cascade

0.75	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
0.60	GO:0005506	iron ion binding
0.52	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.49	GO:0004096	catalase activity
0.44	GO:0047977	hepoxilin-epoxide hydrolase activity
0.43	GO:0020037	heme binding
0.43	GO:0051120	hepoxilin A3 synthase activity
0.37	GO:0097260	eoxin A4 synthase activity
0.36	GO:0019870	potassium channel inhibitor activity
0.34	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)

0.50	GO:0005811	lipid droplet
0.50	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.46	GO:0005829	cytosol
0.38	GO:0042383	sarcolemma
0.33	GO:0005634	nucleus

0.75

EC:1.13.11

GO:0016702

tr|T1FYK2|T1FYK2_HELRO
Uncharacterized protein
Search

0.82	Tubulin polyglutamylase ttll6

0.60	GO:0036211	protein modification process
0.56	GO:0044267	cellular protein metabolic process
0.49	GO:0003353	positive regulation of cilium movement
0.46	GO:0001578	microtubule bundle formation
0.46	GO:0051013	microtubule severing
0.35	GO:0006904	vesicle docking involved in exocytosis
0.34	GO:0003341	cilium movement
0.34	GO:0060271	cilium assembly
0.32	GO:0055114	oxidation-reduction process

0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0070739	protein-glutamic acid ligase activity
0.43	GO:0015631	tubulin binding
0.34	GO:0003884	D-amino-acid oxidase activity
0.33	GO:0005509	calcium ion binding

0.46	GO:0036064	ciliary basal body
0.36	GO:0005874	microtubule
0.34	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.48

EC:6.3.2

GO:0070739

tr|T1FYK3|T1FYK3_HELRO
Uncharacterized protein
Search

NOX3

0.66	NADPH oxidase 3

0.76	GO:0050665	hydrogen peroxide biosynthetic process
0.62	GO:0006979	response to oxidative stress
0.60	GO:0098869	cellular oxidant detoxification
0.59	GO:0042554	superoxide anion generation
0.57	GO:0048839	inner ear development
0.55	GO:0009590	detection of gravity
0.53	GO:0001659	temperature homeostasis
0.53	GO:0055114	oxidation-reduction process
0.52	GO:0051591	response to cAMP
0.51	GO:0048855	adenohypophysis morphogenesis

0.81	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
0.63	GO:0004601	peroxidase activity
0.62	GO:0005509	calcium ion binding
0.56	GO:0020037	heme binding

0.52	GO:0043020	NADPH oxidase complex
0.38	GO:0005737	cytoplasm
0.37	GO:0070062	extracellular exosome
0.37	GO:0016324	apical plasma membrane
0.35	GO:0030054	cell junction

0.81	EC:1.6.3	GO:0050664
0.63	KEGG:R03532	GO:0004601

tr|T1FYK4|T1FYK4_HELRO
Uncharacterized protein
Search

CAPN6

0.67	Calpain family cysteine protease

0.61	GO:0006508	proteolysis
0.58	GO:0051493	regulation of cytoskeleton organization
0.39	GO:0001578	microtubule bundle formation
0.38	GO:0010940	positive regulation of necrotic cell death
0.38	GO:0071230	cellular response to amino acid stimulus
0.38	GO:0051146	striated muscle cell differentiation
0.37	GO:0000768	syncytium formation by plasma membrane fusion
0.37	GO:0001824	blastocyst development
0.36	GO:0007586	digestion
0.36	GO:0044257	cellular protein catabolic process

0.82	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.57	GO:0005509	calcium ion binding
0.37	GO:0008092	cytoskeletal protein binding
0.34	GO:0046982	protein heterodimerization activity
0.33	GO:0008270	zinc ion binding
0.33	GO:0003676	nucleic acid binding

0.45	GO:0005622	intracellular
0.39	GO:0099512	supramolecular fiber
0.38	GO:0031143	pseudopodium
0.37	GO:0043228	non-membrane-bounded organelle
0.37	GO:0044422	organelle part
0.37	GO:0045121	membrane raft
0.35	GO:0030425	dendrite
0.35	GO:0012505	endomembrane system
0.34	GO:0005925	focal adhesion
0.34	GO:0070062	extracellular exosome

tr|T1FYK5|T1FYK5_HELRO
Uncharacterized protein
Search

0.10	Aryl hydrocarbon receptor (Fragment)

0.56	GO:0006351	transcription, DNA-templated
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.47	GO:0009410	response to xenobiotic stimulus
0.47	GO:0048800	antennal morphogenesis
0.47	GO:0045676	regulation of R7 cell differentiation
0.46	GO:0036011	imaginal disc-derived leg segmentation
0.46	GO:0010092	specification of animal organ identity
0.46	GO:0008049	male courtship behavior

0.68	GO:0046983	protein dimerization activity
0.48	GO:0004874	aryl hydrocarbon receptor activity
0.46	GO:0003677	DNA binding
0.45	GO:0003700	DNA binding transcription factor activity
0.36	GO:0003989	acetyl-CoA carboxylase activity

0.60	GO:0005634	nucleus
0.50	GO:0034751	aryl hydrocarbon receptor complex
0.42	GO:0005667	transcription factor complex
0.36	GO:0005737	cytoplasm
0.35	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.36

EC:6.4.1.2

GO:0003989

tr|T1FYK6|T1FYK6_HELRO
Uncharacterized protein
Search

PIGF

0.74	Phosphatidylinositol glycan anchor biosynthesis class F

0.78	GO:0006506	GPI anchor biosynthetic process
0.34	GO:0010466	negative regulation of peptidase activity
0.34	GO:0006606	protein import into nucleus
0.32	GO:0016310	phosphorylation
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.37	GO:0004307	ethanolaminephosphotransferase activity
0.34	GO:0030414	peptidase inhibitor activity
0.34	GO:0061608	nuclear import signal receptor activity
0.33	GO:0008565	protein transporter activity
0.32	GO:0016301	kinase activity
0.32	GO:0003700	DNA binding transcription factor activity
0.32	GO:0003677	DNA binding

0.72	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0005576	extracellular region
0.32	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.37

EC:2.7.8.1

GO:0004307

tr|T1FYK7|T1FYK7_HELRO
Uncharacterized protein
Search

MKLN1

0.94	Muskelin 1, intracellular mediator containing kelch motifs

0.82	GO:0007160	cell-matrix adhesion
0.77	GO:0031532	actin cytoskeleton reorganization
0.69	GO:0008360	regulation of cell shape
0.36	GO:0007165	signal transduction

0.73

GO:0042802

identical protein binding

0.83	GO:0001726	ruffle
0.76	GO:0005938	cell cortex
0.69	GO:0005829	cytosol

tr|T1FYK8|T1FYK8_HELRO
Uncharacterized protein
Search

TRABD

0.90	TraB domain containing

0.37	GO:0006811	ion transport
0.37	GO:0006508	proteolysis

0.38	GO:0008237	metallopeptidase activity
0.36	GO:0003723	RNA binding

0.43	GO:0005921	gap junction
0.37	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1FYK9|T1FYK9_HELRO
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
Search

0.77	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

0.74	GO:0006486	protein glycosylation
0.51	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process
0.46	GO:0030204	chondroitin sulfate metabolic process
0.46	GO:0015012	heparan sulfate proteoglycan biosynthetic process
0.44	GO:0051216	cartilage development
0.43	GO:0030198	extracellular matrix organization
0.39	GO:0005975	carbohydrate metabolic process
0.35	GO:0050651	dermatan sulfate proteoglycan biosynthetic process
0.34	GO:0090316	positive regulation of intracellular protein transport
0.34	GO:0043666	regulation of phosphoprotein phosphatase activity

0.85	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
0.54	GO:0046872	metal ion binding
0.37	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
0.35	GO:0072542	protein phosphatase activator activity

0.74	GO:0000139	Golgi membrane
0.34	GO:0005801	cis-Golgi network
0.34	GO:0031305	integral component of mitochondrial inner membrane

0.85

EC:2.4.1.135

GO:0015018

tr|T1FYL0|T1FYL0_HELRO
Uncharacterized protein
Search

CISD2

0.84	CDGSH iron sulfur domain-containing protein 2

0.48	GO:0007568	aging
0.44	GO:0043457	regulation of cellular respiration
0.44	GO:0007275	multicellular organism development
0.43	GO:0061726	mitochondrion disassembly
0.42	GO:0010506	regulation of autophagy
0.42	GO:0055072	iron ion homeostasis
0.42	GO:0006914	autophagy
0.41	GO:0072593	reactive oxygen species metabolic process

0.71	GO:0051537	2 iron, 2 sulfur cluster binding
0.48	GO:0042802	identical protein binding
0.41	GO:0046983	protein dimerization activity
0.35	GO:0046872	metal ion binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.56	GO:0043231	intracellular membrane-bounded organelle
0.46	GO:0031968	organelle outer membrane
0.42	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.42	GO:0044444	cytoplasmic part
0.41	GO:0031984	organelle subcompartment
0.38	GO:0043234	protein complex
0.35	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

tr|T1FYL1|T1FYL1_HELRO
Uncharacterized protein
Search

0.47	GO:1903288	positive regulation of potassium ion import
0.45	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.45	GO:0035220	wing disc development
0.44	GO:0006325	chromatin organization
0.44	GO:0046777	protein autophosphorylation
0.44	GO:0007411	axon guidance
0.44	GO:0018393	internal peptidyl-lysine acetylation
0.42	GO:2001141	regulation of RNA biosynthetic process
0.41	GO:0044109	cellular alcohol catabolic process
0.41	GO:1900189	positive regulation of cell adhesion involved in single-species biofilm formation

0.54	GO:0008270	zinc ion binding
0.48	GO:0003712	transcription cofactor activity
0.48	GO:0003677	DNA binding
0.44	GO:0004402	histone acetyltransferase activity
0.41	GO:0003682	chromatin binding
0.41	GO:0004674	protein serine/threonine kinase activity
0.40	GO:0015616	DNA translocase activity
0.40	GO:0001102	RNA polymerase II activating transcription factor binding
0.40	GO:0070577	lysine-acetylated histone binding
0.40	GO:0017076	purine nucleotide binding

0.59	GO:0005634	nucleus
0.51	GO:0070013	intracellular organelle lumen
0.46	GO:0043234	protein complex
0.46	GO:0044446	intracellular organelle part
0.43	GO:0031248	protein acetyltransferase complex
0.42	GO:1905368	peptidase complex
0.37	GO:0005694	chromosome
0.36	GO:1904949	ATPase complex
0.30	GO:0016020	membrane

0.44

GO:0004402

tr|T1FYL2|T1FYL2_HELRO
Uncharacterized protein
Search

AGPAT3

0.87	LOW QUALITY PROTEIN: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

0.36	GO:0016024	CDP-diacylglycerol biosynthetic process
0.34	GO:0006654	phosphatidic acid biosynthetic process

0.63

GO:0016746

transferase activity, transferring acyl groups

0.44	GO:0005783	endoplasmic reticulum
0.35	GO:0005635	nuclear envelope
0.35	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.34	GO:0031984	organelle subcompartment
0.33	GO:0044431	Golgi apparatus part
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

0.63

GO:0016746

tr|T1FYL3|T1FYL3_HELRO
Uncharacterized protein
Search

CCDC124

0.64	Coiled-coil domain-containing protein 124-A

0.42	GO:0051301	cell division
0.42	GO:0007049	cell cycle

0.48	GO:0003677	DNA binding
0.36	GO:0003723	RNA binding

0.57	GO:0005829	cytosol
0.52	GO:0005634	nucleus
0.48	GO:0005886	plasma membrane
0.46	GO:0030496	midbody
0.44	GO:0005815	microtubule organizing center
0.30	GO:0031224	intrinsic component of membrane

tr|T1FYL4|T1FYL4_HELRO
Uncharacterized protein
Search

STK26

0.54	Serine/threonine-protein kinase 25

0.63	GO:0006468	protein phosphorylation
0.45	GO:0060439	trachea morphogenesis
0.45	GO:0019991	septate junction assembly
0.39	GO:0030033	microvillus assembly
0.39	GO:1903205	regulation of hydrogen peroxide-induced cell death
0.39	GO:0042981	regulation of apoptotic process
0.38	GO:0042542	response to hydrogen peroxide
0.38	GO:0030336	negative regulation of cell migration
0.38	GO:0009267	cellular response to starvation
0.37	GO:0000185	activation of MAPKKK activity

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0042803	protein homodimerization activity
0.37	GO:0005057	signal transducer activity, downstream of receptor
0.36	GO:0000287	magnesium ion binding

0.38	GO:0016324	apical plasma membrane
0.38	GO:0005794	Golgi apparatus
0.38	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0005798	Golgi-associated vesicle
0.36	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

tr|T1FYL5|T1FYL5_HELRO
Uncharacterized protein
Search

0.60	GO:0005975	carbohydrate metabolic process
0.41	GO:0009057	macromolecule catabolic process
0.40	GO:0044248	cellular catabolic process
0.38	GO:0000226	microtubule cytoskeleton organization
0.36	GO:0044260	cellular macromolecule metabolic process
0.34	GO:0007064	mitotic sister chromatid cohesion
0.33	GO:0006518	peptide metabolic process
0.33	GO:0043604	amide biosynthetic process
0.32	GO:1901566	organonitrogen compound biosynthetic process
0.32	GO:0010467	gene expression

0.66	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.34	GO:0030246	carbohydrate binding
0.33	GO:0003735	structural constituent of ribosome

0.37	GO:0015630	microtubule cytoskeleton
0.34	GO:0031390	Ctf18 RFC-like complex
0.33	GO:0005840	ribosome
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.66

GO:0004553

tr|T1FYL6|T1FYL6_HELRO
Uncharacterized protein
Search

0.54	Mitogen-activated protein kinase kinase kinase 9

0.63	GO:0006468	protein phosphorylation
0.59	GO:0043507	positive regulation of JUN kinase activity
0.59	GO:0000186	activation of MAPKK activity
0.58	GO:0031098	stress-activated protein kinase signaling cascade
0.51	GO:0000187	activation of MAPK activity
0.48	GO:0008283	cell proliferation
0.45	GO:0007017	microtubule-based process
0.42	GO:0043065	positive regulation of apoptotic process
0.38	GO:1901216	positive regulation of neuron death
0.38	GO:0043523	regulation of neuron apoptotic process

0.64	GO:0004672	protein kinase activity
0.56	GO:0005057	signal transducer activity, downstream of receptor
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0031435	mitogen-activated protein kinase kinase kinase binding
0.46	GO:0042803	protein homodimerization activity
0.39	GO:0031434	mitogen-activated protein kinase kinase binding
0.38	GO:0048365	Rac GTPase binding
0.33	GO:0005509	calcium ion binding

0.48	GO:0005813	centrosome
0.45	GO:0005874	microtubule
0.35	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1FYL7|T1FYL7_HELRO
Uncharacterized protein
Search

0.11	Putative syntaxin-binding protein 2 (Fragment)

0.42	GO:1902476	chloride transmembrane transport
0.41	GO:0018193	peptidyl-amino acid modification
0.38	GO:0007186	G-protein coupled receptor signaling pathway
0.38	GO:0006887	exocytosis
0.36	GO:0038007	netrin-activated signaling pathway
0.36	GO:0051601	exocyst localization
0.36	GO:0032501	multicellular organismal process
0.35	GO:0009593	detection of chemical stimulus
0.35	GO:0019343	cysteine biosynthetic process via cystathionine
0.35	GO:0009190	cyclic nucleotide biosynthetic process

0.43	GO:0005247	voltage-gated chloride channel activity
0.38	GO:0008484	sulfuric ester hydrolase activity
0.37	GO:0004871	signal transducer activity
0.36	GO:0005515	protein binding
0.36	GO:0099600	transmembrane receptor activity
0.36	GO:0016829	lyase activity
0.35	GO:0098772	molecular function regulator
0.35	GO:1901265	nucleoside phosphate binding
0.34	GO:0036094	small molecule binding
0.34	GO:0004731	purine-nucleoside phosphorylase activity

0.39	GO:0000145	exocyst
0.37	GO:0005834	heterotrimeric G-protein complex
0.36	GO:0030425	dendrite
0.35	GO:0005576	extracellular region
0.34	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.38

EC:3.1.6

GO:0008484

tr|T1FYL8|T1FYL8_HELRO
Uncharacterized protein
Search

WDR70

0.95	WD repeat domain-containing protein 70

0.71

GO:0019899

enzyme binding

tr|T1FYL9|T1FYL9_HELRO
Uncharacterized protein
Search

SLC12A6

0.59	Potassium-chloride cotransporter-1

0.85	GO:0071477	cellular hypotonic salinity response
0.77	GO:1902476	chloride transmembrane transport
0.44	GO:0007638	mechanosensory behavior
0.40	GO:0006884	cell volume homeostasis
0.39	GO:0007268	chemical synaptic transmission
0.38	GO:0071805	potassium ion transmembrane transport
0.37	GO:0003333	amino acid transmembrane transport
0.35	GO:0034975	protein folding in endoplasmic reticulum

0.85	GO:0015379	potassium:chloride symporter activity
0.39	GO:0022820	potassium ion symporter activity
0.37	GO:0015171	amino acid transmembrane transporter activity

0.67	GO:0005887	integral component of plasma membrane
0.42	GO:0043025	neuronal cell body
0.42	GO:0030424	axon
0.34	GO:0072546	ER membrane protein complex

tr|T1FYM0|T1FYM0_HELRO
Uncharacterized protein
Search

tr|T1FYM1|T1FYM1_HELRO
Uncharacterized protein
Search

0.41	Fatty acid desaturase

0.83	GO:0030148	sphingolipid biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.45	GO:0006672	ceramide metabolic process
0.41	GO:0007053	spindle assembly involved in male meiosis
0.38	GO:0043604	amide biosynthetic process
0.38	GO:0006633	fatty acid biosynthetic process
0.35	GO:0043065	positive regulation of apoptotic process
0.34	GO:0043312	neutrophil degranulation
0.34	GO:0033559	unsaturated fatty acid metabolic process
0.33	GO:0007186	G-protein coupled receptor signaling pathway

0.85	GO:0042284	sphingolipid delta-4 desaturase activity
0.34	GO:0016503	pheromone receptor activity
0.33	GO:0008080	N-acetyltransferase activity
0.33	GO:0009055	electron transfer activity

0.43	GO:0005739	mitochondrion
0.40	GO:0070938	contractile ring
0.38	GO:0005789	endoplasmic reticulum membrane
0.35	GO:0035579	specific granule membrane
0.33	GO:0005887	integral component of plasma membrane

0.33

GO:0008080

tr|T1FYM2|T1FYM2_HELRO
Uncharacterized protein
Search

0.49	Arachidonate 5-lipoxygenase

0.59	GO:0098869	cellular oxidant detoxification
0.53	GO:0055114	oxidation-reduction process
0.37	GO:0019372	lipoxygenase pathway
0.37	GO:0019369	arachidonic acid metabolic process
0.34	GO:0016042	lipid catabolic process
0.34	GO:0016926	protein desumoylation
0.33	GO:0007166	cell surface receptor signaling pathway
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0031408	oxylipin biosynthetic process

0.75	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
0.66	GO:0004096	catalase activity
0.55	GO:0020037	heme binding
0.54	GO:0046872	metal ion binding
0.33	GO:0004930	G-protein coupled receptor activity
0.33	GO:0008234	cysteine-type peptidase activity
0.32	GO:0016853	isomerase activity

0.37	GO:0005634	nucleus
0.33	GO:0034708	methyltransferase complex
0.32	GO:0043233	organelle lumen
0.32	GO:0005737	cytoplasm
0.32	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.75

EC:1.13.11

GO:0016702

tr|T1FYM3|T1FYM3_HELRO
Uncharacterized protein
Search

DDX49

0.95	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49

0.54

GO:0010501

RNA secondary structure unwinding

0.66	GO:0004386	helicase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0008186	RNA-dependent ATPase activity
0.51	GO:0003676	nucleic acid binding
0.45	GO:0140098	catalytic activity, acting on RNA

0.50	GO:0005730	nucleolus
0.39	GO:0005737	cytoplasm

tr|T1FYM4|T1FYM4_HELRO
Uncharacterized protein
Search

tr|T1FYM5|T1FYM5_HELRO
SAGA-associated factor 11
Search

SGF11

0.61	SAGA-associated factor 11

0.77	GO:0016578	histone deubiquitination
0.68	GO:0045893	positive regulation of transcription, DNA-templated
0.55	GO:0006351	transcription, DNA-templated
0.42	GO:0051028	mRNA transport
0.39	GO:0015031	protein transport
0.36	GO:0071166	ribonucleoprotein complex localization
0.36	GO:0051169	nuclear transport
0.35	GO:0006405	RNA export from nucleus
0.35	GO:0003341	cilium movement
0.35	GO:0034613	cellular protein localization

0.72	GO:0003713	transcription coactivator activity
0.58	GO:0008270	zinc ion binding
0.34	GO:0005215	transporter activity
0.34	GO:0003777	microtubule motor activity
0.33	GO:0016887	ATPase activity
0.33	GO:0003677	DNA binding
0.33	GO:0016757	transferase activity, transferring glycosyl groups
0.32	GO:0005515	protein binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding

0.79	GO:0071819	DUBm complex
0.74	GO:0000124	SAGA complex
0.42	GO:0005643	nuclear pore
0.35	GO:0005737	cytoplasm
0.34	GO:0030286	dynein complex
0.34	GO:0044441	ciliary part
0.30	GO:0016020	membrane

0.33

GO:0016887

tr|T1FYM6|T1FYM6_HELRO
Uncharacterized protein
Search

0.56	GO:0007015	actin filament organization
0.55	GO:0007155	cell adhesion
0.54	GO:0035023	regulation of Rho protein signal transduction
0.48	GO:0065009	regulation of molecular function
0.46	GO:0035556	intracellular signal transduction
0.41	GO:0055114	oxidation-reduction process

0.54	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.47	GO:0005509	calcium ion binding
0.42	GO:0016491	oxidoreductase activity

0.38	GO:0005622	intracellular
0.30	GO:0044425	membrane part

0.42

GO:0016491

tr|T1FYM7|T1FYM7_HELRO
Flap endonuclease 1
Search

FEN1

0.64	Flap endonuclease 1

0.82	GO:0043137	DNA replication, removal of RNA primer
0.69	GO:0006284	base-excision repair
0.64	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.55	GO:0045876	positive regulation of sister chromatid cohesion
0.38	GO:0007613	memory
0.36	GO:0030262	apoptotic nuclear changes
0.36	GO:0033260	nuclear DNA replication
0.35	GO:0009411	response to UV
0.35	GO:0006302	double-strand break repair
0.35	GO:0006308	DNA catabolic process

0.79	GO:0048256	flap endonuclease activity
0.74	GO:0008409	5'-3' exonuclease activity
0.72	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters
0.62	GO:0000287	magnesium ion binding
0.55	GO:0003677	DNA binding
0.48	GO:0004523	RNA-DNA hybrid ribonuclease activity
0.36	GO:0008309	double-stranded DNA exodeoxyribonuclease activity
0.35	GO:0030145	manganese ion binding
0.34	GO:0008297	single-stranded DNA exodeoxyribonuclease activity
0.33	GO:0005515	protein binding

0.72	GO:0005730	nucleolus
0.68	GO:0005654	nucleoplasm
0.60	GO:0005739	mitochondrion
0.51	GO:0000784	nuclear chromosome, telomeric region
0.42	GO:0043234	protein complex
0.34	GO:0035861	site of double-strand break
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.72

EC:3.1.21

GO:0016888

tr|T1FYM8|T1FYM8_HELRO
Uncharacterized protein
Search

tr|T1FYM9|T1FYM9_HELRO
Uncharacterized protein
Search

CCDC94

0.89	Coiled-coil domain-containing protein 94

0.77	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
0.73	GO:0043524	negative regulation of neuron apoptotic process
0.47	GO:0019221	cytokine-mediated signaling pathway
0.46	GO:0000349	generation of catalytic spliceosome for first transesterification step

0.47	GO:0004896	cytokine receptor activity
0.46	GO:0000384	first spliceosomal transesterification activity
0.38	GO:0005515	protein binding

0.47	GO:0005684	U2-type spliceosomal complex
0.45	GO:0071012	catalytic step 1 spliceosome
0.30	GO:0016020	membrane

tr|T1FYN0|T1FYN0_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.52	GO:0060269	centripetally migrating follicle cell migration
0.52	GO:0042247	establishment of planar polarity of follicular epithelium
0.52	GO:1902463	protein localization to cell leading edge
0.52	GO:0007295	growth of a germarium-derived egg chamber
0.51	GO:0007440	foregut morphogenesis
0.50	GO:0007442	hindgut morphogenesis
0.50	GO:0051491	positive regulation of filopodium assembly
0.49	GO:0030950	establishment or maintenance of actin cytoskeleton polarity
0.49	GO:0007431	salivary gland development

0.70	GO:0005509	calcium ion binding
0.47	GO:0050839	cell adhesion molecule binding
0.46	GO:0032403	protein complex binding
0.37	GO:0004872	receptor activity
0.35	GO:0004871	signal transducer activity

0.55	GO:0005886	plasma membrane
0.51	GO:0098858	actin-based cell projection
0.51	GO:0031254	cell trailing edge
0.49	GO:0045178	basal part of cell
0.48	GO:0005925	focal adhesion
0.41	GO:0032421	stereocilium bundle
0.39	GO:0043005	neuron projection
0.36	GO:0044422	organelle part
0.30	GO:0016021	integral component of membrane

tr|T1FYN1|T1FYN1_HELRO
Uncharacterized protein
Search

tr|T1FYN2|T1FYN2_HELRO
Synaptotagmin 7a
Search

SYT7

0.89	Synaptotagmin VIIb

0.76	GO:0006887	exocytosis
0.53	GO:0099643	signal release from synapse
0.53	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.51	GO:0017158	regulation of calcium ion-dependent exocytosis
0.51	GO:0090119	vesicle-mediated cholesterol transport
0.50	GO:1990926	short-term synaptic potentiation
0.50	GO:0048489	synaptic vesicle transport
0.50	GO:0099504	synaptic vesicle cycle
0.50	GO:0070092	regulation of glucagon secretion
0.50	GO:0006836	neurotransmitter transport

0.81	GO:0005544	calcium-dependent phospholipid binding
0.50	GO:0000149	SNARE binding
0.48	GO:0001786	phosphatidylserine binding
0.48	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.46	GO:0005516	calmodulin binding
0.44	GO:0030276	clathrin binding
0.41	GO:0005509	calcium ion binding

0.51	GO:0098793	presynapse
0.49	GO:0032009	early phagosome
0.48	GO:0070382	exocytic vesicle
0.47	GO:0044306	neuron projection terminus
0.47	GO:0005764	lysosome
0.46	GO:0043025	neuronal cell body
0.46	GO:0030425	dendrite
0.46	GO:0097060	synaptic membrane
0.45	GO:0005777	peroxisome
0.42	GO:0005829	cytosol

tr|T1FYN3|T1FYN3_HELRO
Uncharacterized protein
Search

0.50	Serine/threonine-protein kinase svkA

0.63	GO:0006468	protein phosphorylation
0.44	GO:0060439	trachea morphogenesis
0.44	GO:0019991	septate junction assembly
0.42	GO:0032147	activation of protein kinase activity
0.42	GO:0031098	stress-activated protein kinase signaling cascade
0.41	GO:0043410	positive regulation of MAPK cascade
0.41	GO:0043405	regulation of MAP kinase activity
0.41	GO:0071902	positive regulation of protein serine/threonine kinase activity
0.40	GO:0042981	regulation of apoptotic process
0.40	GO:0007346	regulation of mitotic cell cycle

0.64	GO:0004672	protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0005057	signal transducer activity, downstream of receptor
0.36	GO:0042803	protein homodimerization activity
0.34	GO:0003839	gamma-glutamylcyclotransferase activity
0.33	GO:0003779	actin binding
0.33	GO:0000287	magnesium ion binding

0.37	GO:0097610	cell surface furrow
0.36	GO:0032155	cell division site part
0.36	GO:0005794	Golgi apparatus
0.36	GO:0005813	centrosome
0.35	GO:0015629	actin cytoskeleton
0.34	GO:0005829	cytosol
0.34	GO:0016324	apical plasma membrane
0.34	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0005819	spindle
0.33	GO:0005798	Golgi-associated vesicle

0.34

EC:2.3.2.4

GO:0003839

tr|T1FYN4|T1FYN4_HELRO
Uncharacterized protein
Search

SPTLC2

0.84	Serine palmitoyltransferase long chain base subunit 2

0.57	GO:0046511	sphinganine biosynthetic process
0.56	GO:0006686	sphingomyelin biosynthetic process
0.56	GO:1904502	regulation of lipophagy
0.55	GO:0046512	sphingosine biosynthetic process
0.54	GO:0046513	ceramide biosynthetic process
0.53	GO:0016239	positive regulation of macroautophagy

0.67	GO:0030170	pyridoxal phosphate binding
0.55	GO:0004758	serine C-palmitoyltransferase activity

0.55	GO:0017059	serine C-palmitoyltransferase complex
0.43	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.55	EC:2.3.1.50	GO:0004758
0.55	KEGG:R01281	GO:0004758

tr|T1FYN5|T1FYN5_HELRO
Uncharacterized protein
Search

0.45	Gamma-glutamyl transpeptidase

0.78	GO:0006751	glutathione catabolic process
0.61	GO:0006508	proteolysis
0.36	GO:0006805	xenobiotic metabolic process
0.36	GO:0009416	response to light stimulus
0.34	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0006352	DNA-templated transcription, initiation
0.33	GO:0071897	DNA biosynthetic process
0.33	GO:0006260	DNA replication
0.33	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.80	GO:0036374	glutathione hydrolase activity
0.39	GO:0103068	leukotriene C4 gamma-glutamyl transferase activity
0.39	GO:0102953	hypoglycin A gamma-glutamyl transpeptidase activity
0.34	GO:0004930	G-protein coupled receptor activity
0.34	GO:0008408	3'-5' exonuclease activity
0.34	GO:0003887	DNA-directed DNA polymerase activity
0.33	GO:0001882	nucleoside binding
0.32	GO:0003677	DNA binding
0.32	GO:1901265	nucleoside phosphate binding

0.36	GO:0000324	fungal-type vacuole
0.36	GO:0005615	extracellular space
0.34	GO:0005669	transcription factor TFIID complex
0.30	GO:0016020	membrane

0.80	EC:3.4.19.13	GO:0036374
0.80	KEGG:R00494	GO:0036374

tr|T1FYN6|T1FYN6_HELRO
Transmembrane 9 superfamily member
Search

TM9SF4

0.54	Transmembrane 9 superfamily member

0.53	GO:0070863	positive regulation of protein exit from endoplasmic reticulum
0.53	GO:2000010	positive regulation of protein localization to cell surface
0.51	GO:0006909	phagocytosis
0.51	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly
0.51	GO:0051453	regulation of intracellular pH
0.50	GO:0001666	response to hypoxia
0.46	GO:0007155	cell adhesion
0.36	GO:0006265	DNA topological change
0.35	GO:0061060	negative regulation of peptidoglycan recognition protein signaling pathway
0.35	GO:0035010	encapsulation of foreign target

0.37	GO:0003917	DNA topoisomerase type I activity
0.34	GO:0003677	DNA binding
0.33	GO:0005515	protein binding
0.33	GO:0008270	zinc ion binding

0.49	GO:0005769	early endosome
0.46	GO:0005794	Golgi apparatus
0.34	GO:0005694	chromosome
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.37

EC:5.99.1.2

GO:0003917

tr|T1FYN7|T1FYN7_HELRO
Proline iminopeptidase
Search

PIP

0.52	Proline iminopeptidase

0.57

GO:0006508

proteolysis

0.67	GO:0004177	aminopeptidase activity
0.32	GO:0016746	transferase activity, transferring acyl groups

0.47	GO:0005737	cytoplasm
0.33	GO:0005615	extracellular space

0.67

EC:3.4.11

GO:0004177

tr|T1FYN8|T1FYN8_HELRO
Uncharacterized protein
Search

GPR108

0.88	Lung seven transmembrane receptor

0.43

GO:0072583

clathrin-dependent endocytosis

0.48	GO:0032050	clathrin heavy chain binding
0.33	GO:0005509	calcium ion binding

0.45	GO:0005769	early endosome
0.45	GO:0030136	clathrin-coated vesicle
0.42	GO:0005794	Golgi apparatus
0.42	GO:0005654	nucleoplasm
0.30	GO:0044425	membrane part

tr|T1FYN9|T1FYN9_HELRO
Uncharacterized protein
Search

0.44	Potassium voltage-gated channel protein Shab

0.75	GO:0051260	protein homooligomerization
0.75	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport

0.78

GO:0005249

voltage-gated potassium channel activity

0.78

GO:0008076

voltage-gated potassium channel complex

tr|T1FYP0|T1FYP0_HELRO
Uncharacterized protein
Search

EIF2S2

0.82	Eukaryotic translation initiation factor

0.72	GO:0006413	translational initiation
0.48	GO:0002176	male germ cell proliferation
0.45	GO:0008584	male gonad development
0.43	GO:0001701	in utero embryonic development
0.36	GO:0016199	axon midline choice point recognition
0.36	GO:0016567	protein ubiquitination
0.35	GO:0034976	response to endoplasmic reticulum stress
0.34	GO:0002181	cytoplasmic translation
0.33	GO:0022618	ribonucleoprotein complex assembly
0.33	GO:0001522	pseudouridine synthesis

0.73	GO:0003743	translation initiation factor activity
0.36	GO:0004842	ubiquitin-protein transferase activity
0.34	GO:0005515	protein binding
0.34	GO:0046872	metal ion binding
0.33	GO:0009982	pseudouridine synthase activity

0.50	GO:0005850	eukaryotic translation initiation factor 2 complex
0.34	GO:0043614	multi-eIF complex
0.34	GO:0005829	cytosol
0.34	GO:0016282	eukaryotic 43S preinitiation complex
0.34	GO:0005634	nucleus
0.33	GO:0019013	viral nucleocapsid
0.30	GO:0016020	membrane

0.33	EC:5.4.99.12	GO:0009982
0.36	KEGG:R03876	GO:0004842

tr|T1FYP1|T1FYP1_HELRO
Uncharacterized protein
Search

0.37	GO:0010019	chloroplast-nucleus signaling pathway
0.37	GO:0030097	hemopoiesis
0.36	GO:0006959	humoral immune response
0.36	GO:0045893	positive regulation of transcription, DNA-templated
0.36	GO:0002458	peripheral T cell tolerance induction
0.36	GO:0002509	central tolerance induction to self antigen
0.36	GO:0016567	protein ubiquitination
0.36	GO:0033333	fin development
0.36	GO:0097536	thymus epithelium morphogenesis
0.36	GO:2000410	regulation of thymocyte migration

0.58	GO:0008270	zinc ion binding
0.42	GO:0016874	ligase activity
0.39	GO:0042393	histone binding
0.38	GO:0140030	modification-dependent protein binding
0.37	GO:0045182	translation regulator activity
0.36	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.36	GO:0003682	chromatin binding
0.36	GO:0002039	p53 binding
0.35	GO:0003712	transcription cofactor activity
0.35	GO:0000987	proximal promoter sequence-specific DNA binding

0.43	GO:0016235	aggresome
0.41	GO:0005654	nucleoplasm
0.37	GO:0009707	chloroplast outer membrane
0.34	GO:0000783	nuclear telomere cap complex
0.33	GO:0090575	RNA polymerase II transcription factor complex
0.33	GO:0055029	nuclear DNA-directed RNA polymerase complex
0.30	GO:0031224	intrinsic component of membrane

0.42	EC:6	GO:0016874
0.34	KEGG:R03876	GO:0004842

tr|T1FYP2|T1FYP2_HELRO
Uncharacterized protein
Search

0.43	GO:0070896	positive regulation of transposon integration
0.42	GO:0016348	imaginal disc-derived leg joint morphogenesis
0.42	GO:0018992	germ-line sex determination
0.42	GO:0035017	cuticle pattern formation
0.42	GO:0048067	cuticle pigmentation
0.42	GO:0035316	non-sensory hair organization
0.42	GO:0008343	adult feeding behavior
0.40	GO:0000122	negative regulation of transcription by RNA polymerase II
0.39	GO:0045944	positive regulation of transcription by RNA polymerase II
0.38	GO:0007010	cytoskeleton organization

0.51	GO:0003676	nucleic acid binding
0.35	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.33	GO:0046872	metal ion binding

0.38	GO:0005634	nucleus
0.33	GO:0043233	organelle lumen
0.32	GO:0044446	intracellular organelle part
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1FYP3|T1FYP3_HELRO
Uncharacterized protein
Search

0.63	GO:0006629	lipid metabolic process
0.53	GO:0055114	oxidation-reduction process
0.41	GO:0007124	pseudohyphal growth
0.39	GO:0046165	alcohol biosynthetic process
0.38	GO:0046164	alcohol catabolic process
0.38	GO:1901360	organic cyclic compound metabolic process
0.36	GO:0044248	cellular catabolic process
0.36	GO:1901137	carbohydrate derivative biosynthetic process
0.34	GO:0044249	cellular biosynthetic process

0.68	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
0.51	GO:0016229	steroid dehydrogenase activity

0.49	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

0.68

EC:1.3

GO:0016627

tr|T1FYP4|T1FYP4_HELRO
Uncharacterized protein
Search

NEMF

0.92	Nuclear export mediator factor Nemf

0.75

GO:0051168

nuclear export

0.39

GO:0005634

nucleus

tr|T1FYP5|T1FYP5_HELRO
Uncharacterized protein
Search

TRMU

0.58	Mitochondrial tRNA-specific 2-thiouridylase

0.66	GO:0008033	tRNA processing
0.54	GO:0009451	RNA modification
0.44	GO:0032259	methylation
0.41	GO:0000963	mitochondrial RNA processing
0.39	GO:0070525	tRNA threonylcarbamoyladenosine metabolic process
0.34	GO:0032981	mitochondrial respiratory chain complex I assembly
0.32	GO:0044260	cellular macromolecule metabolic process

0.72	GO:0016783	sulfurtransferase activity
0.56	GO:0000049	tRNA binding
0.46	GO:0032559	adenyl ribonucleotide binding
0.46	GO:0008144	drug binding
0.46	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0008168	methyltransferase activity
0.34	GO:0140101	catalytic activity, acting on a tRNA

0.44	GO:0005737	cytoplasm
0.41	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.72

EC:2.8.1

GO:0016783

tr|T1FYP6|T1FYP6_HELRO
Uncharacterized protein
Search

0.48	FMRFamide receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.54	GO:0008344	adult locomotory behavior
0.49	GO:0008345	larval locomotory behavior
0.49	GO:0002209	behavioral defense response

0.78	GO:0008528	G-protein coupled peptide receptor activity
0.33	GO:0050660	flavin adenine dinucleotide binding
0.30	GO:0003824	catalytic activity

0.46

GO:0005887

integral component of plasma membrane

tr|T1FYP7|T1FYP7_HELRO
Uncharacterized protein
Search

MAP2K4

0.90	Dual specificity mitogen-activated protein kinase kinase 4

0.63	GO:0006468	protein phosphorylation
0.52	GO:2000672	negative regulation of motor neuron apoptotic process
0.51	GO:0034393	positive regulation of smooth muscle cell apoptotic process
0.50	GO:0071260	cellular response to mechanical stimulus
0.50	GO:0031098	stress-activated protein kinase signaling cascade
0.49	GO:0032147	activation of protein kinase activity
0.47	GO:0009611	response to wounding
0.46	GO:0043507	positive regulation of JUN kinase activity
0.45	GO:0048082	regulation of adult chitin-containing cuticle pigmentation
0.43	GO:0007346	regulation of mitotic cell cycle

0.67	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0004708	MAP kinase kinase activity
0.40	GO:0031435	mitogen-activated protein kinase kinase kinase binding
0.36	GO:0005057	signal transducer activity, downstream of receptor
0.35	GO:0004713	protein tyrosine kinase activity
0.32	GO:0003723	RNA binding

0.44	GO:0030424	axon
0.40	GO:0032839	dendrite cytoplasm
0.39	GO:0043204	perikaryon
0.36	GO:0005829	cytosol
0.35	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.67

GO:0004674

tr|T1FYP8|T1FYP8_HELRO
Uncharacterized protein
Search

TRPGAMMA

0.86	Transient receptor potential channel gamma

0.77	GO:0070588	calcium ion transmembrane transport
0.39	GO:0006828	manganese ion transport
0.39	GO:0051480	regulation of cytosolic calcium ion concentration
0.35	GO:0050884	neuromuscular process controlling posture
0.35	GO:0050908	detection of light stimulus involved in visual perception
0.35	GO:0007628	adult walking behavior

0.80	GO:0005262	calcium channel activity
0.34	GO:0008381	mechanosensitive ion channel activity
0.33	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.33	GO:0005515	protein binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0016740	transferase activity

0.37	GO:0005887	integral component of plasma membrane
0.36	GO:1990635	proximal dendrite
0.35	GO:0016028	rhabdomere
0.35	GO:0043025	neuronal cell body
0.34	GO:0034703	cation channel complex

0.32

GO:0016740

tr|T1FYP9|T1FYP9_HELRO
Uncharacterized protein
Search

0.81	ER-derived vesicles protein, putative

0.69	GO:0016192	vesicle-mediated transport
0.34	GO:0070084	protein initiator methionine removal
0.34	GO:0046907	intracellular transport
0.33	GO:0006508	proteolysis
0.33	GO:0015031	protein transport
0.33	GO:0000398	mRNA splicing, via spliceosome

0.34	GO:0070006	metalloaminopeptidase activity
0.32	GO:0046872	metal ion binding

0.35	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.34	GO:0005783	endoplasmic reticulum
0.33	GO:0005838	proteasome regulatory particle
0.33	GO:0071013	catalytic step 2 spliceosome
0.30	GO:0016020	membrane

tr|T1FYQ0|T1FYQ0_HELRO
Uncharacterized protein
Search

0.40	NAD-dependent protein deacetylase

0.51	GO:0006471	protein ADP-ribosylation
0.50	GO:0006476	protein deacetylation
0.35	GO:0006397	mRNA processing
0.34	GO:0006468	protein phosphorylation
0.33	GO:0006782	protoporphyrinogen IX biosynthetic process
0.32	GO:0032259	methylation
0.32	GO:0055114	oxidation-reduction process

0.77	GO:0070403	NAD+ binding
0.51	GO:0034979	NAD-dependent protein deacetylase activity
0.44	GO:0008270	zinc ion binding
0.34	GO:0016740	transferase activity
0.34	GO:0003723	RNA binding
0.33	GO:0004853	uroporphyrinogen decarboxylase activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0032553	ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.48	GO:0005759	mitochondrial matrix
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0016740

tr|T1FYQ1|T1FYQ1_HELRO
Uncharacterized protein
Search

SLC35F1

0.83	Solute carrier family 35 member F1

0.55	GO:0055085	transmembrane transport
0.35	GO:0043547	positive regulation of GTPase activity

0.57	GO:0022857	transmembrane transporter activity
0.35	GO:0005096	GTPase activator activity

0.30

GO:0016020

membrane

tr|T1FYQ2|T1FYQ2_HELRO
Uncharacterized protein
Search

0.71	Adiponectin receptor

0.44	GO:0036099	female germ-line stem cell population maintenance
0.44	GO:0009755	hormone-mediated signaling pathway
0.43	GO:0070328	triglyceride homeostasis
0.43	GO:0032024	positive regulation of insulin secretion
0.42	GO:0042593	glucose homeostasis
0.39	GO:0019221	cytokine-mediated signaling pathway
0.36	GO:0046321	positive regulation of fatty acid oxidation
0.34	GO:0019395	fatty acid oxidation

0.40	GO:0042562	hormone binding
0.37	GO:0004872	receptor activity
0.33	GO:0046872	metal ion binding
0.30	GO:0003824	catalytic activity

0.35	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1FYQ3|T1FYQ3_HELRO
Uncharacterized protein
Search

tr|T1FYQ4|T1FYQ4_HELRO
Uncharacterized protein
Search

0.50	TNF receptor-associated factor 3

0.80	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.79	GO:0008063	Toll signaling pathway
0.78	GO:0032088	negative regulation of NF-kappaB transcription factor activity
0.78	GO:0050688	regulation of defense response to virus
0.73	GO:0001817	regulation of cytokine production
0.72	GO:0045087	innate immune response
0.71	GO:0042981	regulation of apoptotic process
0.51	GO:0002224	toll-like receptor signaling pathway
0.48	GO:0030162	regulation of proteolysis
0.42	GO:0007250	activation of NF-kappaB-inducing kinase activity

0.79	GO:0005164	tumor necrosis factor receptor binding
0.61	GO:0008270	zinc ion binding
0.55	GO:0031996	thioesterase binding
0.51	GO:0019903	protein phosphatase binding
0.50	GO:0031625	ubiquitin protein ligase binding
0.49	GO:0019901	protein kinase binding
0.40	GO:0004842	ubiquitin-protein transferase activity
0.34	GO:0042802	identical protein binding
0.33	GO:0004871	signal transducer activity

0.54	GO:0035631	CD40 receptor complex
0.48	GO:0009898	cytoplasmic side of plasma membrane
0.35	GO:0005768	endosome
0.33	GO:0005829	cytosol
0.33	GO:0005739	mitochondrion

0.40

GO:0004842

tr|T1FYQ5|T1FYQ5_HELRO
Uncharacterized protein
Search

RASEF

0.62	RAS and EF-hand domain containing

0.47

GO:0051260

protein homooligomerization

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.59	GO:0005509	calcium ion binding
0.54	GO:0032553	ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0042802	identical protein binding

0.48	GO:0048471	perinuclear region of cytoplasm
0.44	GO:0005829	cytosol

tr|T1FYQ6|T1FYQ6_HELRO
Uncharacterized protein
Search

0.63	GO:0006468	protein phosphorylation
0.42	GO:0045850	positive regulation of nurse cell apoptotic process
0.42	GO:0045476	nurse cell apoptotic process
0.42	GO:0045819	positive regulation of glycogen catabolic process
0.42	GO:0061723	glycophagy
0.41	GO:0035096	larval midgut cell programmed cell death
0.41	GO:2000331	regulation of terminal button organization
0.41	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
0.41	GO:0051124	synaptic growth at neuromuscular junction
0.41	GO:0008088	axo-dendritic transport

0.67	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0032182	ubiquitin-like protein binding

0.40	GO:1990316	Atg1/ULK1 kinase complex
0.40	GO:0043005	neuron projection
0.34	GO:0043025	neuronal cell body
0.30	GO:0016020	membrane

0.67

GO:0004674

tr|T1FYQ7|T1FYQ7_HELRO
Uncharacterized protein
Search

tr|T1FYQ8|T1FYQ8_HELRO
POU domain protein
Search

0.52	POU domain protein (Fragment)

0.58	GO:0007420	brain development
0.57	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.38	GO:0030154	cell differentiation
0.37	GO:0007588	excretion
0.36	GO:0030104	water homeostasis
0.35	GO:0072227	metanephric macula densa development
0.35	GO:0043066	negative regulation of apoptotic process

0.63	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.35	GO:0001012	RNA polymerase II regulatory region DNA binding
0.35	GO:0071837	HMG box domain binding
0.35	GO:0003690	double-stranded DNA binding
0.34	GO:0035326	enhancer binding

0.61	GO:0005634	nucleus
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

tr|T1FYQ9|T1FYQ9_HELRO
Uncharacterized protein
Search

tr|T1FYR0|T1FYR0_HELRO
Tyrosine-protein kinase
Search

0.48	Tyrosine-protein kinase Fps85D

0.77

GO:0018108

peptidyl-tyrosine phosphorylation

0.77	GO:0004713	protein tyrosine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.77

GO:0004713

tr|T1FYR1|T1FYR1_HELRO
Uncharacterized protein
Search

0.72	GO:0016579	protein deubiquitination
0.44	GO:0055090	acylglycerol homeostasis
0.43	GO:0008340	determination of adult lifespan
0.43	GO:0031098	stress-activated protein kinase signaling cascade
0.42	GO:0042742	defense response to bacterium
0.40	GO:0045088	regulation of innate immune response
0.40	GO:0006979	response to oxidative stress
0.38	GO:0002181	cytoplasmic translation
0.34	GO:0030071	regulation of mitotic metaphase/anaphase transition
0.33	GO:0006511	ubiquitin-dependent protein catabolic process

0.72	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.46	GO:0061815	ubiquitinyl hydrolase activity, acting on linear ubiquitin
0.44	GO:0061578	Lys63-specific deubiquitinase activity
0.36	GO:0003735	structural constituent of ribosome
0.32	GO:0016740	transferase activity

0.38	GO:0005840	ribosome
0.37	GO:0005829	cytosol
0.34	GO:0005680	anaphase-promoting complex
0.30	GO:0016021	integral component of membrane

0.72

GO:0036459

tr|T1FYR2|T1FYR2_HELRO
Uncharacterized protein
Search

DYM

0.83	Reprolysin

0.80	GO:0007030	Golgi organization
0.75	GO:0060348	bone development

0.64

GO:0019899

enzyme binding

0.70	GO:0005794	Golgi apparatus
0.30	GO:0044425	membrane part

tr|T1FYR3|T1FYR3_HELRO
Uncharacterized protein
Search

tr|T1FYR4|T1FYR4_HELRO
LIM domain-containing protein
Search

0.79	LIM and senescent cell antigen-containing domain protein 1

0.42	GO:0043043	peptide biosynthetic process
0.40	GO:0044267	cellular protein metabolic process
0.39	GO:0010467	gene expression
0.39	GO:0097659	nucleic acid-templated transcription
0.39	GO:2001141	regulation of RNA biosynthetic process
0.39	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.39	GO:0010468	regulation of gene expression
0.39	GO:0034645	cellular macromolecule biosynthetic process
0.38	GO:0060047	heart contraction
0.37	GO:0051896	regulation of protein kinase B signaling

0.53	GO:0046872	metal ion binding
0.43	GO:0003735	structural constituent of ribosome
0.43	GO:0046983	protein dimerization activity
0.38	GO:0003677	DNA binding
0.34	GO:0019901	protein kinase binding

0.42	GO:0005840	ribosome
0.40	GO:0005634	nucleus
0.38	GO:0014704	intercalated disc
0.37	GO:0030018	Z disc
0.34	GO:0005925	focal adhesion
0.34	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0016020	membrane

tr|T1FYR5|T1FYR5_HELRO
Uncharacterized protein
Search

tr|T1FYR6|T1FYR6_HELRO
Uncharacterized protein
Search

0.65	Prolactin-releasing peptide receptor

0.79	GO:0007218	neuropeptide signaling pathway
0.44	GO:0043408	regulation of MAPK cascade
0.43	GO:2000479	regulation of cAMP-dependent protein kinase activity
0.42	GO:0045761	regulation of adenylate cyclase activity
0.41	GO:2000253	positive regulation of feeding behavior
0.41	GO:0040018	positive regulation of multicellular organism growth
0.39	GO:0001934	positive regulation of protein phosphorylation
0.39	GO:1902533	positive regulation of intracellular signal transduction
0.36	GO:0003214	cardiac left ventricle morphogenesis
0.35	GO:0003151	outflow tract morphogenesis

0.82	GO:0004983	neuropeptide Y receptor activity
0.43	GO:0031628	opioid receptor binding
0.43	GO:0036400	short neuropeptide F receptor activity
0.37	GO:0050254	rhodopsin kinase activity
0.34	GO:0042277	peptide binding
0.34	GO:0004950	chemokine receptor activity
0.33	GO:0019956	chemokine binding
0.33	GO:0004985	opioid receptor activity
0.33	GO:0070915	lysophosphatidic acid receptor activity
0.33	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity

0.38	GO:0005887	integral component of plasma membrane
0.35	GO:0097730	non-motile cilium
0.34	GO:0015629	actin cytoskeleton
0.32	GO:0009897	external side of plasma membrane

0.37	EC:2.7.11.14	GO:0050254
0.33	KEGG:R05802	GO:0000285

tr|T1FYR7|T1FYR7_HELRO
Uncharacterized protein
Search

C1GALT1

0.72	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase

0.84	GO:0016266	O-glycan processing
0.43	GO:1902037	negative regulation of hematopoietic stem cell differentiation
0.42	GO:0021551	central nervous system morphogenesis
0.41	GO:0051489	regulation of filopodium assembly
0.41	GO:0048468	cell development
0.41	GO:0007528	neuromuscular junction development
0.40	GO:0042692	muscle cell differentiation
0.39	GO:0001525	angiogenesis
0.39	GO:0060575	intestinal epithelial cell differentiation
0.39	GO:0001822	kidney development

0.84	GO:0048531	beta-1,3-galactosyltransferase activity
0.79	GO:0140103	catalytic activity, acting on a glycoprotein
0.38	GO:0046872	metal ion binding
0.34	GO:0008146	sulfotransferase activity
0.33	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.37	GO:0005797	Golgi medial cisterna
0.30	GO:0016020	membrane

0.34

EC:2.8.2

GO:0008146

tr|T1FYR8|T1FYR8_HELRO
Uncharacterized protein
Search

WDR3

0.67	WD repeat-containing protein 3

0.75	GO:0030490	maturation of SSU-rRNA
0.61	GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.60	GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.59	GO:0000967	rRNA 5'-end processing
0.46	GO:0051209	release of sequestered calcium ion into cytosol
0.37	GO:0000132	establishment of mitotic spindle orientation
0.35	GO:0051301	cell division
0.35	GO:0006468	protein phosphorylation

0.80	GO:0030515	snoRNA binding
0.47	GO:0005219	ryanodine-sensitive calcium-release channel activity
0.37	GO:0070840	dynein complex binding
0.35	GO:0016905	myosin heavy chain kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.84	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome
0.76	GO:0032040	small-subunit processome
0.44	GO:0031965	nuclear membrane
0.36	GO:0005875	microtubule associated complex
0.36	GO:0005815	microtubule organizing center
0.36	GO:0005874	microtubule
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.35

EC:2.7.11.7

GO:0016905

tr|T1FYR9|T1FYR9_HELRO
Uncharacterized protein
Search

BCKDK

0.86	Branched chain alpha-ketoacid dehydrogenase kinase

0.57	GO:0016310	phosphorylation
0.39	GO:0006464	cellular protein modification process

0.57	GO:0016772	transferase activity, transferring phosphorus-containing groups
0.38	GO:0140096	catalytic activity, acting on a protein

0.39	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.57

EC:2.7

GO:0016772

tr|T1FYS0|T1FYS0_HELRO
Uncharacterized protein
Search

tr|T1FYS1|T1FYS1_HELRO
Uncharacterized protein
Search

0.46	Thyrotropin-releasing hormone receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.46	GO:0046662	regulation of oviposition
0.44	GO:0045434	negative regulation of female receptivity, post-mating
0.39	GO:0048521	negative regulation of behavior
0.38	GO:2000242	negative regulation of reproductive process
0.37	GO:0051241	negative regulation of multicellular organismal process
0.33	GO:0035556	intracellular signal transduction

0.78

GO:0008528

G-protein coupled peptide receptor activity

0.36	GO:0005886	plasma membrane
0.31	GO:0005622	intracellular
0.30	GO:0044425	membrane part

tr|T1FYS2|T1FYS2_HELRO
Uncharacterized protein
Search

DNAL1

0.81	Outer arm dynein light chain 2

0.78	GO:0036158	outer dynein arm assembly
0.39	GO:0007165	signal transduction
0.39	GO:0043666	regulation of phosphoprotein phosphatase activity
0.38	GO:0035383	thioester metabolic process
0.37	GO:0006631	fatty acid metabolic process
0.36	GO:0006732	coenzyme metabolic process
0.35	GO:0006793	phosphorus metabolic process
0.34	GO:0055114	oxidation-reduction process

0.78	GO:0045504	dynein heavy chain binding
0.77	GO:0043014	alpha-tubulin binding
0.48	GO:0003774	motor activity
0.40	GO:0047617	acyl-CoA hydrolase activity
0.39	GO:0003924	GTPase activity
0.39	GO:0019888	protein phosphatase regulator activity
0.39	GO:0032550	purine ribonucleoside binding
0.39	GO:0019001	guanyl nucleotide binding
0.38	GO:0030246	carbohydrate binding
0.36	GO:0032555	purine ribonucleotide binding

0.50	GO:0030286	dynein complex
0.48	GO:0005874	microtubule
0.47	GO:0042995	cell projection
0.39	GO:0000159	protein phosphatase type 2A complex
0.39	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.40

EC:3.1.2 EC:3.1.2.20

GO:0047617

tr|T1FYS3|T1FYS3_HELRO
Uncharacterized protein
Search

0.74	Mitochondrial succinate dehydrogenase assembly factor 1

tr|T1FYS4|T1FYS4_HELRO
Uncharacterized protein
Search

0.66	GO:0061098	positive regulation of protein tyrosine kinase activity
0.58	GO:0006897	endocytosis
0.57	GO:0007015	actin filament organization
0.48	GO:0009651	response to salt stress
0.47	GO:0030838	positive regulation of actin filament polymerization
0.39	GO:0035023	regulation of Rho protein signal transduction
0.39	GO:0007264	small GTPase mediated signal transduction
0.38	GO:0007155	cell adhesion
0.37	GO:0006468	protein phosphorylation

0.68	GO:0030296	protein tyrosine kinase activator activity
0.54	GO:0043130	ubiquitin binding
0.53	GO:0030674	protein binding, bridging
0.51	GO:0008092	cytoskeletal protein binding
0.50	GO:0042802	identical protein binding
0.39	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.37	GO:0004672	protein kinase activity
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding

0.62	GO:0005912	adherens junction
0.48	GO:0030479	actin cortical patch
0.39	GO:0005886	plasma membrane

tr|T1FYS5|T1FYS5_HELRO
Uncharacterized protein
Search

0.76	NAD-dependent protein deacetylase sirtuin-1 (Fragment)

0.57	GO:2000654	regulation of cellular response to testosterone stimulus
0.56	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair
0.56	GO:0010934	macrophage cytokine production
0.56	GO:2000111	positive regulation of macrophage apoptotic process
0.56	GO:0031393	negative regulation of prostaglandin biosynthetic process
0.56	GO:1904177	regulation of adipose tissue development
0.56	GO:2000481	positive regulation of cAMP-dependent protein kinase activity
0.56	GO:2000619	negative regulation of histone H4-K16 acetylation
0.55	GO:1900113	negative regulation of histone H3-K9 trimethylation
0.55	GO:0042595	behavioral response to starvation

0.77	GO:0070403	NAD+ binding
0.56	GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
0.56	GO:0043398	HLH domain binding
0.55	GO:1990254	keratin filament binding
0.54	GO:0051019	mitogen-activated protein kinase binding
0.54	GO:0043425	bHLH transcription factor binding
0.53	GO:0002039	p53 binding
0.52	GO:0035257	nuclear hormone receptor binding
0.52	GO:0001046	core promoter sequence-specific DNA binding
0.51	GO:0008022	protein C-terminus binding

0.54	GO:0005677	chromatin silencing complex
0.53	GO:0033553	rDNA heterochromatin
0.52	GO:0005719	nuclear euchromatin
0.52	GO:0016605	PML body
0.52	GO:0005720	nuclear heterochromatin
0.52	GO:0035098	ESC/E(Z) complex
0.51	GO:0005637	nuclear inner membrane
0.47	GO:0005730	nucleolus
0.46	GO:0005829	cytosol
0.43	GO:0005739	mitochondrion

0.34

EC:2.4.2.30

GO:0003950

tr|T1FYS6|T1FYS6_HELRO
Uncharacterized protein
Search

0.60	Stromal membrane-associated protein 1

0.76	GO:0043547	positive regulation of GTPase activity
0.42	GO:2000369	regulation of clathrin-dependent endocytosis
0.42	GO:0045648	positive regulation of erythrocyte differentiation
0.37	GO:0031532	actin cytoskeleton reorganization

0.76	GO:0005096	GTPase activator activity
0.52	GO:0046872	metal ion binding
0.40	GO:0030276	clathrin binding

0.35	GO:0005886	plasma membrane
0.34	GO:0005737	cytoplasm

tr|T1FYS7|T1FYS7_HELRO
Uncharacterized protein
Search

CPEB1

0.94	Cytoplasmic polyadenylation element-binding protein 1-B

0.72	GO:0006417	regulation of translation
0.45	GO:0034249	negative regulation of cellular amide metabolic process
0.44	GO:0032269	negative regulation of cellular protein metabolic process
0.44	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
0.43	GO:0010629	negative regulation of gene expression
0.41	GO:0071456	cellular response to hypoxia
0.41	GO:0071230	cellular response to amino acid stimulus
0.41	GO:0032869	cellular response to insulin stimulus
0.39	GO:0006518	peptide metabolic process
0.39	GO:0043604	amide biosynthetic process

0.84	GO:0003730	mRNA 3'-UTR binding
0.83	GO:0045182	translation regulator activity
0.43	GO:0043022	ribosome binding
0.42	GO:0017091	AU-rich element binding
0.41	GO:0008135	translation factor activity, RNA binding
0.35	GO:0046872	metal ion binding
0.35	GO:0005515	protein binding
0.33	GO:0003735	structural constituent of ribosome

0.48	GO:1990124	messenger ribonucleoprotein complex
0.45	GO:0043005	neuron projection
0.44	GO:0045202	synapse
0.41	GO:0005634	nucleus
0.38	GO:0036464	cytoplasmic ribonucleoprotein granule
0.38	GO:0120038	plasma membrane bounded cell projection part
0.37	GO:0036477	somatodendritic compartment
0.37	GO:0030054	cell junction
0.37	GO:0005819	spindle
0.37	GO:0098590	plasma membrane region

tr|T1FYS8|T1FYS8_HELRO
Uncharacterized protein
Search

0.60	GO:0010951	negative regulation of endopeptidase activity
0.37	GO:0006508	proteolysis
0.36	GO:0042176	regulation of protein catabolic process

0.62	GO:0004867	serine-type endopeptidase inhibitor activity
0.41	GO:0005518	collagen binding
0.38	GO:0008233	peptidase activity

0.73	GO:0005615	extracellular space
0.40	GO:0031012	extracellular matrix
0.35	GO:1903561	extracellular vesicle
0.33	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

0.38

GO:0008233

tr|T1FYS9|T1FYS9_HELRO
Uncharacterized protein
Search

JOSD2

0.87	Josephin domain-containing 2

0.76	GO:0016579	protein deubiquitination
0.46	GO:1904888	cranial skeletal system development
0.42	GO:0021551	central nervous system morphogenesis
0.34	GO:0051965	positive regulation of synapse assembly
0.34	GO:0006742	NADP catabolic process
0.33	GO:0019363	pyridine nucleotide biosynthetic process
0.32	GO:0055114	oxidation-reduction process

0.80	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.33	GO:0050661	NADP binding
0.32	GO:0005515	protein binding
0.32	GO:0016491	oxidoreductase activity

0.34	GO:0005886	plasma membrane
0.33	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.32

GO:0016491

tr|T1FYT0|T1FYT0_HELRO
Uncharacterized protein
Search

0.58	Homeobox protein ceh-23 (inferred by orthology to a C. elegans protein)

0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.50	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
0.49	GO:0021527	spinal cord association neuron differentiation
0.49	GO:2000744	positive regulation of anterior head development
0.49	GO:0021702	cerebellar Purkinje cell differentiation
0.49	GO:0097477	lateral motor column neuron migration
0.49	GO:2000768	positive regulation of nephron tubule epithelial cell differentiation
0.49	GO:0061205	paramesonephric duct development

0.64	GO:0043565	sequence-specific DNA binding
0.45	GO:0046872	metal ion binding
0.40	GO:0003714	transcription corepressor activity
0.40	GO:0003700	DNA binding transcription factor activity
0.33	GO:0035326	enhancer binding
0.33	GO:0005515	protein binding
0.33	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.39	GO:0043234	protein complex
0.30	GO:0016020	membrane

tr|T1FYT1|T1FYT1_HELRO
Uncharacterized protein
Search

tr|T1FYT2|T1FYT2_HELRO
Uncharacterized protein
Search

CSK

0.27	Tyrosine-protein kinase

0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.55	GO:0042997	negative regulation of Golgi to plasma membrane protein transport
0.53	GO:0042127	regulation of cell proliferation
0.50	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.49	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway
0.46	GO:0007275	multicellular organism development
0.46	GO:0034332	adherens junction organization
0.46	GO:0046777	protein autophosphorylation
0.45	GO:0001817	regulation of cytokine production
0.44	GO:0044344	cellular response to fibroblast growth factor stimulus

0.76	GO:0004713	protein tyrosine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0034236	protein kinase A catalytic subunit binding
0.48	GO:0019199	transmembrane receptor protein kinase activity
0.47	GO:0042802	identical protein binding
0.43	GO:0005102	receptor binding
0.39	GO:0019903	protein phosphatase binding

0.48	GO:0005911	cell-cell junction
0.45	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.38	GO:0098857	membrane microdomain
0.38	GO:0035230	cytoneme
0.37	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome
0.35	GO:0005634	nucleus
0.34	GO:0030027	lamellipodium
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0030133	transport vesicle

0.76

GO:0004713

tr|T1FYT3|T1FYT3_HELRO
Uncharacterized protein
Search

0.57	GO:0019857	5-methylcytosine metabolic process
0.55	GO:0030099	myeloid cell differentiation
0.55	GO:0080182	histone H3-K4 trimethylation
0.54	GO:0070988	demethylation
0.52	GO:0006493	protein O-linked glycosylation
0.50	GO:0035510	DNA dealkylation
0.50	GO:0055114	oxidation-reduction process
0.50	GO:0072529	pyrimidine-containing compound catabolic process
0.49	GO:0045944	positive regulation of transcription by RNA polymerase II
0.48	GO:0044728	DNA methylation or demethylation

0.65	GO:0051213	dioxygenase activity
0.50	GO:0008198	ferrous iron binding
0.46	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.46	GO:0008270	zinc ion binding
0.37	GO:0003677	DNA binding
0.35	GO:0005515	protein binding

0.35	GO:0001940	male pronucleus
0.34	GO:0005654	nucleoplasm
0.33	GO:0005694	chromosome
0.32	GO:0005737	cytoplasm

0.46

GO:0016705

tr|T1FYT4|T1FYT4_HELRO
Mitogen-activated protein kinase
Search

0.51	Mitogen-activated protein kinase

0.78	GO:0000165	MAPK cascade
0.38	GO:1904355	positive regulation of telomere capping
0.37	GO:0051973	positive regulation of telomerase activity
0.37	GO:0032212	positive regulation of telomere maintenance via telomerase
0.37	GO:0010468	regulation of gene expression
0.37	GO:0046777	protein autophosphorylation

0.80	GO:0004707	MAP kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0005622	intracellular
0.37	GO:0043227	membrane-bounded organelle
0.30	GO:0016020	membrane

0.80	EC:2.7.11.24	GO:0004707
0.80	KEGG:R00162	GO:0004707

tr|T1FYT5|T1FYT5_HELRO
Uncharacterized protein
Search

0.44	GO:0070896	positive regulation of transposon integration
0.44	GO:0016348	imaginal disc-derived leg joint morphogenesis
0.43	GO:0018992	germ-line sex determination
0.43	GO:0035017	cuticle pattern formation
0.43	GO:0048067	cuticle pigmentation
0.43	GO:0035316	non-sensory hair organization
0.43	GO:0008343	adult feeding behavior
0.41	GO:0000122	negative regulation of transcription by RNA polymerase II
0.40	GO:0045944	positive regulation of transcription by RNA polymerase II
0.39	GO:0007010	cytoskeleton organization

0.51	GO:0003676	nucleic acid binding
0.36	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.33	GO:0046872	metal ion binding

0.38	GO:0005634	nucleus
0.33	GO:0043233	organelle lumen
0.32	GO:0044446	intracellular organelle part
0.32	GO:0005737	cytoplasm

tr|T1FYT6|T1FYT6_HELRO
Uncharacterized protein
Search

0.86	Tyrosine hydroxylase

0.81	GO:0042423	catecholamine biosynthetic process
0.69	GO:0009072	aromatic amino acid family metabolic process
0.58	GO:0007617	mating behavior
0.58	GO:0042417	dopamine metabolic process
0.54	GO:0042414	epinephrine metabolic process
0.53	GO:0035176	social behavior
0.53	GO:0007625	grooming behavior
0.53	GO:0055114	oxidation-reduction process
0.53	GO:0071625	vocalization behavior
0.52	GO:0001963	synaptic transmission, dopaminergic

0.84	GO:0004511	tyrosine 3-monooxygenase activity
0.63	GO:0005506	iron ion binding
0.45	GO:0019899	enzyme binding
0.42	GO:0004510	tryptophan 5-monooxygenase activity
0.39	GO:0034617	tetrahydrobiopterin binding
0.38	GO:0035240	dopamine binding
0.37	GO:0019825	oxygen binding
0.36	GO:0019904	protein domain specific binding
0.36	GO:0016597	amino acid binding
0.34	GO:0005179	hormone activity

0.52	GO:0033162	melanosome membrane
0.52	GO:0005790	smooth endoplasmic reticulum
0.51	GO:0043204	perikaryon
0.49	GO:0030424	axon
0.47	GO:0009898	cytoplasmic side of plasma membrane
0.42	GO:0005634	nucleus
0.37	GO:0043679	axon terminus
0.37	GO:0008021	synaptic vesicle
0.37	GO:0030425	dendrite
0.35	GO:0005829	cytosol

0.84

EC:1.14.16.2

GO:0004511

tr|T1FYT7|T1FYT7_HELRO
Uncharacterized protein
Search

0.13	DNA mismatch repair protein MutT

0.43

GO:0009132

nucleoside diphosphate metabolic process

0.51	GO:0016787	hydrolase activity
0.44	GO:0030145	manganese ion binding
0.41	GO:0000287	magnesium ion binding

0.51

GO:0016787

tr|T1FYT8|T1FYT8_HELRO
Uncharacterized protein
Search

tr|T1FYT9|T1FYT9_HELRO
Uncharacterized protein
Search

0.18	Kv channel-interacting protein 4-like

0.70

GO:0005509

calcium ion binding

tr|T1FYU0|T1FYU0_HELRO
Uncharacterized protein
Search

0.59	Putative molecular chaperone

tr|T1FYU1|T1FYU1_HELRO
Uncharacterized protein
Search

tr|T1FYU2|T1FYU2_HELRO
Uncharacterized protein
Search

tr|T1FYU3|T1FYU3_HELRO
Uncharacterized protein
Search

0.41	GO:0006397	mRNA processing
0.41	GO:0006379	mRNA cleavage
0.40	GO:0043631	RNA polyadenylation
0.40	GO:0031123	RNA 3'-end processing
0.39	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
0.39	GO:0006413	translational initiation

0.41	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
0.41	GO:0004386	helicase activity
0.39	GO:0003743	translation initiation factor activity
0.39	GO:0005509	calcium ion binding
0.37	GO:0030554	adenyl nucleotide binding
0.37	GO:0032555	purine ribonucleotide binding
0.37	GO:0008144	drug binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding

0.42	GO:0044451	nucleoplasm part
0.40	GO:0090575	RNA polymerase II transcription factor complex
0.39	GO:0055029	nuclear DNA-directed RNA polymerase complex
0.30	GO:0016020	membrane

0.41	EC:3.2.1.113	GO:0004571
0.41	KEGG:R05982 KEGG:R06722	GO:0004571

tr|T1FYU4|T1FYU4_HELRO
Uncharacterized protein
Search

0.52	GO:0007016	cytoskeletal anchoring at plasma membrane
0.50	GO:0001558	regulation of cell growth
0.44	GO:0031032	actomyosin structure organization
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression
0.32	GO:0042981	regulation of apoptotic process
0.32	GO:0007165	signal transduction

0.68	GO:0008092	cytoskeletal protein binding
0.51	GO:0005198	structural molecule activity
0.32	GO:0003677	DNA binding
0.32	GO:0008270	zinc ion binding

0.69	GO:0005856	cytoskeleton
0.49	GO:0005911	cell-cell junction
0.42	GO:0005886	plasma membrane
0.34	GO:0005912	adherens junction
0.30	GO:0016021	integral component of membrane

tr|T1FYU5|T1FYU5_HELRO
Uncharacterized protein
Search

0.39	Serine/threonine kinase

0.63	GO:0006468	protein phosphorylation
0.59	GO:0016049	cell growth
0.57	GO:0006915	apoptotic process
0.54	GO:0007010	cytoskeleton organization
0.49	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
0.49	GO:0007613	memory
0.48	GO:0007612	learning
0.48	GO:0007626	locomotory behavior
0.45	GO:0007266	Rho protein signal transduction
0.44	GO:0032147	activation of protein kinase activity

0.66	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0017048	Rho GTPase binding
0.36	GO:0035173	histone kinase activity
0.36	GO:0005057	signal transducer activity, downstream of receptor
0.35	GO:0098641	cadherin binding involved in cell-cell adhesion
0.32	GO:0008270	zinc ion binding

0.44	GO:0005654	nucleoplasm
0.41	GO:0005913	cell-cell adherens junction
0.40	GO:0005739	mitochondrion
0.36	GO:0000131	incipient cellular bud site
0.36	GO:0043332	mating projection tip
0.35	GO:0071944	cell periphery
0.34	GO:0071521	Cdc42 GTPase complex
0.34	GO:0070938	contractile ring
0.34	GO:0051286	cell tip
0.33	GO:0005876	spindle microtubule

0.66

GO:0004674

tr|T1FYU6|T1FYU6_HELRO
Uncharacterized protein
Search

0.48	FMRFamide receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.54	GO:0008344	adult locomotory behavior
0.49	GO:0008345	larval locomotory behavior
0.49	GO:0002209	behavioral defense response

0.78	GO:0008528	G-protein coupled peptide receptor activity
0.33	GO:0050660	flavin adenine dinucleotide binding
0.30	GO:0003824	catalytic activity

0.46

GO:0005887

integral component of plasma membrane

tr|T1FYU7|T1FYU7_HELRO
Uncharacterized protein
Search

0.40	Transketolase b

0.40	GO:0031935	regulation of chromatin silencing
0.30	GO:0008152	metabolic process

0.38

GO:0004802

transketolase activity

0.34

GO:0005829

cytosol

0.38

EC:2.2.1.1

GO:0004802

tr|T1FYU8|T1FYU8_HELRO
Uncharacterized protein
Search

DYNC2H1

0.88	LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1

0.74	GO:0007018	microtubule-based movement
0.55	GO:0045880	positive regulation of smoothened signaling pathway
0.55	GO:0060976	coronary vasculature development
0.54	GO:0021522	spinal cord motor neuron differentiation
0.54	GO:0061512	protein localization to cilium
0.53	GO:1905515	non-motile cilium assembly
0.53	GO:0031503	protein complex localization
0.53	GO:0030326	embryonic limb morphogenesis
0.53	GO:0030705	cytoskeleton-dependent intracellular transport
0.53	GO:0007368	determination of left/right symmetry

0.75	GO:0003777	microtubule motor activity
0.61	GO:0016887	ATPase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0045503	dynein light chain binding
0.49	GO:0051959	dynein light intermediate chain binding
0.49	GO:0045505	dynein intermediate chain binding
0.32	GO:0015369	calcium:proton antiporter activity

0.77	GO:0030286	dynein complex
0.53	GO:0005930	axoneme
0.53	GO:0031514	motile cilium
0.52	GO:0045177	apical part of cell
0.40	GO:0005874	microtubule
0.39	GO:0005794	Golgi apparatus
0.36	GO:0070062	extracellular exosome
0.36	GO:0005886	plasma membrane
0.32	GO:0097730	non-motile cilium
0.31	GO:0098588	bounding membrane of organelle

0.61

GO:0016887

tr|T1FYU9|T1FYU9_HELRO
Uncharacterized protein
Search

0.64	Sterol regulatory element binding protein 1 (Fragment)

0.52	GO:0003062	regulation of heart rate by chemical signal
0.52	GO:0045542	positive regulation of cholesterol biosynthetic process
0.52	GO:0010867	positive regulation of triglyceride biosynthetic process
0.51	GO:0031065	positive regulation of histone deacetylation
0.51	GO:0042789	mRNA transcription by RNA polymerase II
0.50	GO:0046676	negative regulation of insulin secretion
0.50	GO:0008286	insulin receptor signaling pathway
0.49	GO:0045444	fat cell differentiation
0.49	GO:1903146	regulation of autophagy of mitochondrion
0.49	GO:0009749	response to glucose

0.68	GO:0046983	protein dimerization activity
0.52	GO:0032810	sterol response element binding
0.48	GO:0004879	nuclear receptor activity
0.48	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.47	GO:0019901	protein kinase binding
0.46	GO:0003682	chromatin binding
0.36	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.36	GO:0032403	protein complex binding

0.42	GO:0005634	nucleus
0.38	GO:0012507	ER to Golgi transport vesicle membrane
0.37	GO:0000139	Golgi membrane
0.37	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0070013	intracellular organelle lumen
0.34	GO:0043234	protein complex
0.33	GO:0005829	cytosol
0.33	GO:0031967	organelle envelope
0.30	GO:0016021	integral component of membrane

tr|T1FYV0|T1FYV0_HELRO
Uncharacterized protein
Search

WASF2

0.62	Wiskott-Aldrich syndrome protein family member 3

0.74	GO:0030036	actin cytoskeleton organization
0.49	GO:0051497	negative regulation of stress fiber assembly
0.49	GO:0010592	positive regulation of lamellipodium assembly
0.49	GO:0072673	lamellipodium morphogenesis
0.48	GO:0030032	lamellipodium assembly
0.48	GO:0035855	megakaryocyte development
0.48	GO:0016601	Rac protein signal transduction
0.47	GO:0030048	actin filament-based movement
0.46	GO:0001667	ameboidal-type cell migration
0.46	GO:0001525	angiogenesis

0.67	GO:0003779	actin binding
0.47	GO:0051018	protein kinase A binding
0.46	GO:0045296	cadherin binding
0.46	GO:0017124	SH3 domain binding
0.44	GO:0032403	protein complex binding

0.69	GO:0005856	cytoskeleton
0.48	GO:0031209	SCAR complex
0.47	GO:0030027	lamellipodium
0.46	GO:0001726	ruffle
0.45	GO:0005769	early endosome
0.44	GO:0005911	cell-cell junction
0.33	GO:0070062	extracellular exosome
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

tr|T1FYV1|T1FYV1_HELRO
Uncharacterized protein
Search

RNFT2

0.66	RING finger and transmembrane domain-containing protein 2

0.33	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.33	GO:0000209	protein polyubiquitination
0.33	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

0.37	GO:0046872	metal ion binding
0.36	GO:0016874	ligase activity
0.33	GO:0061630	ubiquitin protein ligase activity
0.32	GO:0035091	phosphatidylinositol binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.30

GO:0031224

intrinsic component of membrane

0.36

GO:0016874

tr|T1FYV2|T1FYV2_HELRO
Uncharacterized protein
Search

0.64	Potassium voltage-gated channel protein Shaker

0.76	GO:0051260	protein homooligomerization
0.75	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.34	GO:0007166	cell surface receptor signaling pathway
0.34	GO:0086052	membrane repolarization during SA node cell action potential
0.34	GO:0086050	membrane repolarization during bundle of His cell action potential
0.33	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential
0.33	GO:0060081	membrane hyperpolarization
0.33	GO:0043267	negative regulation of potassium ion transport
0.33	GO:0086091	regulation of heart rate by cardiac conduction

0.78	GO:0005249	voltage-gated potassium channel activity
0.34	GO:0004970	ionotropic glutamate receptor activity
0.33	GO:0019870	potassium channel inhibitor activity
0.33	GO:0051393	alpha-actinin binding
0.33	GO:0097110	scaffold protein binding
0.33	GO:0019901	protein kinase binding
0.31	GO:0005509	calcium ion binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.33	GO:0014704	intercalated disc
0.33	GO:0045121	membrane raft
0.33	GO:0030424	axon
0.32	GO:0005578	proteinaceous extracellular matrix

tr|T1FYV3|T1FYV3_HELRO
Uncharacterized protein
Search

0.90	Apoptosis-inducing factor

0.53

GO:0055114

oxidation-reduction process

0.68	GO:0046983	protein dimerization activity
0.66	GO:0050660	flavin adenine dinucleotide binding
0.54	GO:0016491	oxidoreductase activity

0.30

GO:0031224

intrinsic component of membrane

0.54

GO:0016491

tr|T1FYV4|T1FYV4_HELRO
Uncharacterized protein
Search

0.71	GO:0007166	cell surface receptor signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.67	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.53	GO:0036515	serotonergic neuron axon guidance
0.53	GO:0036514	dopaminergic neuron axon guidance
0.52	GO:0007413	axonal fasciculation
0.51	GO:0090175	regulation of establishment of planar polarity
0.50	GO:0001764	neuron migration
0.48	GO:0060271	cilium assembly
0.48	GO:0198738	cell-cell signaling by wnt

0.72	GO:0004930	G-protein coupled receptor activity
0.62	GO:0005509	calcium ion binding
0.40	GO:0030246	carbohydrate binding
0.40	GO:0015116	sulfate transmembrane transporter activity
0.38	GO:0015291	secondary active transmembrane transporter activity
0.36	GO:0005044	scavenger receptor activity
0.35	GO:0004175	endopeptidase activity
0.35	GO:0003993	acid phosphatase activity
0.34	GO:0001871	pattern binding
0.33	GO:0005515	protein binding

0.49	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.35

EC:3.1.3.2

GO:0003993

tr|T1FYV5|T1FYV5_HELRO
Uncharacterized protein
Search

0.67	DENN domain-containing protein 1B

0.75	GO:0032483	regulation of Rab protein signal transduction
0.72	GO:0048488	synaptic vesicle endocytosis
0.71	GO:0032456	endocytic recycling
0.64	GO:0043547	positive regulation of GTPase activity
0.41	GO:0035745	T-helper 2 cell cytokine production
0.41	GO:0015031	protein transport
0.40	GO:0050852	T cell receptor signaling pathway
0.38	GO:0042450	arginine biosynthetic process via ornithine
0.37	GO:0006090	pyruvate metabolic process
0.36	GO:0006629	lipid metabolic process

0.72	GO:0017112	Rab guanyl-nucleotide exchange factor activity
0.70	GO:0032266	phosphatidylinositol-3-phosphate binding
0.67	GO:0017124	SH3 domain binding
0.39	GO:0102965	alcohol-forming fatty acyl-CoA reductase activity
0.39	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity
0.39	GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity
0.38	GO:0004056	argininosuccinate lyase activity

0.69	GO:0030665	clathrin-coated vesicle membrane
0.67	GO:0043025	neuronal cell body
0.67	GO:0030425	dendrite
0.64	GO:0045202	synapse
0.59	GO:0005654	nucleoplasm
0.58	GO:0005829	cytosol
0.45	GO:0098590	plasma membrane region
0.44	GO:0030054	cell junction
0.39	GO:0045254	pyruvate dehydrogenase complex
0.38	GO:0005759	mitochondrial matrix

0.39

EC:2.3.1.12

GO:0004742

tr|T1FYV6|T1FYV6_HELRO
Uncharacterized protein
Search

0.47	Neuropeptide Y receptor type

0.77	GO:0007218	neuropeptide signaling pathway
0.37	GO:0045761	regulation of adenylate cyclase activity
0.36	GO:0030536	larval feeding behavior
0.36	GO:0030818	negative regulation of cAMP biosynthetic process
0.36	GO:0031280	negative regulation of cyclase activity
0.36	GO:0051350	negative regulation of lyase activity
0.35	GO:2000479	regulation of cAMP-dependent protein kinase activity
0.34	GO:0032870	cellular response to hormone stimulus
0.34	GO:0043408	regulation of MAPK cascade
0.34	GO:1901652	response to peptide

0.80	GO:0004983	neuropeptide Y receptor activity
0.37	GO:0042263	neuropeptide F receptor activity
0.35	GO:0050254	rhodopsin kinase activity
0.35	GO:0031628	opioid receptor binding
0.34	GO:0004994	somatostatin receptor activity
0.33	GO:0042277	peptide binding

0.35

GO:0005887

integral component of plasma membrane

0.35

GO:0050254

tr|T1FYV7|T1FYV7_HELRO
Uncharacterized protein
Search

0.48	GO:0071897	DNA biosynthetic process
0.46	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.40	GO:0006749	glutathione metabolic process
0.40	GO:0051716	cellular response to stimulus
0.39	GO:0007155	cell adhesion
0.39	GO:0045454	cell redox homeostasis
0.39	GO:0098754	detoxification
0.39	GO:0023052	signaling
0.38	GO:0007154	cell communication
0.36	GO:0006351	transcription, DNA-templated

0.48	GO:0034061	DNA polymerase activity
0.47	GO:0004519	endonuclease activity
0.42	GO:0004527	exonuclease activity
0.42	GO:0005509	calcium ion binding
0.42	GO:0004362	glutathione-disulfide reductase activity
0.41	GO:0003861	3-isopropylmalate dehydratase activity
0.41	GO:0043531	ADP binding
0.39	GO:0046983	protein dimerization activity
0.39	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.39	GO:0050661	NADP binding

0.37	GO:0005634	nucleus
0.36	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.42

EC:1.8.1.7

GO:0004362

tr|T1FYV8|T1FYV8_HELRO
Uncharacterized protein
Search

SIK1

0.39	Serine-threonine protein kinase (Fragment)

0.63	GO:0006468	protein phosphorylation
0.46	GO:0035556	intracellular signal transduction
0.44	GO:0032870	cellular response to hormone stimulus
0.43	GO:0010868	negative regulation of triglyceride biosynthetic process
0.43	GO:0032792	negative regulation of CREB transcription factor activity
0.43	GO:0043276	anoikis
0.42	GO:0043153	entrainment of circadian clock by photoperiod
0.42	GO:0010830	regulation of myotube differentiation
0.42	GO:0045721	negative regulation of gluconeogenesis
0.42	GO:0055007	cardiac muscle cell differentiation

0.69	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0000287	magnesium ion binding
0.42	GO:0008140	cAMP response element binding protein binding
0.41	GO:0042826	histone deacetylase binding
0.40	GO:0019901	protein kinase binding

0.41	GO:0005634	nucleus
0.37	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.69

GO:0004674

tr|T1FYV9|T1FYV9_HELRO
Uncharacterized protein
Search

0.82	Potassium voltage-gated channel, subfamily F, member 1b

0.74	GO:0051260	protein homooligomerization
0.73	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.39	GO:0035235	ionotropic glutamate receptor signaling pathway

0.77	GO:0005249	voltage-gated potassium channel activity
0.39	GO:0004970	ionotropic glutamate receptor activity
0.32	GO:0005509	calcium ion binding

0.77	GO:0008076	voltage-gated potassium channel complex
0.32	GO:0005578	proteinaceous extracellular matrix

tr|T1FYW0|T1FYW0_HELRO
Uncharacterized protein
Search

GPN2

0.76	P-loop containing nucleoside triphosphate hydrolases superfamily protein

0.75	GO:1902182	shoot apical meristem development
0.72	GO:1990022	RNA polymerase III complex localization to nucleus
0.72	GO:0044376	RNA polymerase II complex import to nucleus
0.67	GO:0009658	chloroplast organization
0.67	GO:0009793	embryo development ending in seed dormancy
0.55	GO:0051301	cell division
0.37	GO:0045454	cell redox homeostasis

0.56	GO:0003924	GTPase activity
0.42	GO:0032550	purine ribonucleoside binding
0.42	GO:0019001	guanyl nucleotide binding
0.38	GO:0032555	purine ribonucleotide binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0016853	isomerase activity

0.60	GO:0005874	microtubule
0.43	GO:0005737	cytoplasm
0.37	GO:0012505	endomembrane system
0.35	GO:0043231	intracellular membrane-bounded organelle

0.36

GO:0016853

tr|T1FYW1|T1FYW1_HELRO
Uncharacterized protein
Search

PRRX2

0.89	Paired mesoderm homeobox protein 2 (Fragment)

0.65	GO:0007275	multicellular organism development
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.49	GO:0007601	visual perception
0.48	GO:0006366	transcription by RNA polymerase II
0.39	GO:1904888	cranial skeletal system development
0.37	GO:0009888	tissue development
0.36	GO:0002053	positive regulation of mesenchymal cell proliferation
0.36	GO:0045880	positive regulation of smoothened signaling pathway

0.64	GO:0043565	sequence-specific DNA binding
0.43	GO:0003700	DNA binding transcription factor activity
0.37	GO:0071837	HMG box domain binding
0.35	GO:0001012	RNA polymerase II regulatory region DNA binding
0.35	GO:0003690	double-stranded DNA binding

0.61

GO:0005634

nucleus

tr|T1FYW2|T1FYW2_HELRO
Poly [ADP-ribose] polymerase
Search

PARP16

0.57	Poly [ADP-ribose] polymerase

0.59	GO:0070213	protein auto-ADP-ribosylation
0.58	GO:0006987	activation of signaling protein activity involved in unfolded protein response
0.55	GO:1990830	cellular response to leukemia inhibitory factor
0.53	GO:0071902	positive regulation of protein serine/threonine kinase activity
0.52	GO:0060548	negative regulation of cell death
0.35	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway
0.33	GO:0015986	ATP synthesis coupled proton transport
0.33	GO:0006396	RNA processing

0.82	GO:0003950	NAD+ ADP-ribosyltransferase activity
0.55	GO:0043539	protein serine/threonine kinase activator activity
0.52	GO:0019900	kinase binding
0.33	GO:0015078	hydrogen ion transmembrane transporter activity

0.56	GO:0071782	endoplasmic reticulum tubular network
0.51	GO:0005635	nuclear envelope
0.36	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
0.33	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.82

EC:2.4.2.30

GO:0003950

tr|T1FYW3|T1FYW3_HELRO
Uncharacterized protein
Search

0.56	Dynein heavy chain axonemal

0.74	GO:0007018	microtubule-based movement
0.39	GO:0001539	cilium or flagellum-dependent cell motility
0.37	GO:1902358	sulfate transmembrane transport
0.34	GO:0016310	phosphorylation

0.75	GO:0003777	microtubule motor activity
0.53	GO:0016887	ATPase activity
0.52	GO:0032559	adenyl ribonucleotide binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0045503	dynein light chain binding
0.47	GO:0051959	dynein light intermediate chain binding
0.47	GO:0045505	dynein intermediate chain binding
0.37	GO:0003951	NAD+ kinase activity
0.37	GO:0015116	sulfate transmembrane transporter activity

0.79	GO:0030286	dynein complex
0.49	GO:0005929	cilium
0.44	GO:0032838	plasma membrane bounded cell projection cytoplasm
0.30	GO:0016020	membrane

0.53	EC:3.6.1.3	GO:0016887
0.37	KEGG:R00104	GO:0003951

tr|T1FYW4|T1FYW4_HELRO
Uncharacterized protein
Search

PIH1D3

0.95	PIH1 domain containing 3

tr|T1FYW5|T1FYW5_HELRO
Uncharacterized protein
Search

0.67	Held out wings

0.64	GO:0006417	regulation of translation
0.35	GO:0060538	skeletal muscle organ development
0.35	GO:0007438	oenocyte development
0.35	GO:0007284	spermatogonial cell division
0.35	GO:0007521	muscle cell fate determination
0.35	GO:1903311	regulation of mRNA metabolic process
0.35	GO:0009888	tissue development
0.34	GO:0008078	mesodermal cell migration
0.34	GO:0007525	somatic muscle development
0.34	GO:0030718	germ-line stem cell population maintenance

0.71	GO:0003727	single-stranded RNA binding
0.34	GO:0003730	mRNA 3'-UTR binding
0.34	GO:0017124	SH3 domain binding
0.33	GO:0004713	protein tyrosine kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.34	GO:0005634	nucleus
0.32	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.33

GO:0004713

tr|T1FYW6|T1FYW6_HELRO
Uncharacterized protein
Search

tr|T1FYW7|T1FYW7_HELRO
Uncharacterized protein
Search

0.49	Syntaxin 6

0.72	GO:0048193	Golgi vesicle transport
0.62	GO:0006886	intracellular protein transport
0.62	GO:0061025	membrane fusion
0.49	GO:0090161	Golgi ribbon formation
0.49	GO:0048284	organelle fusion
0.48	GO:0016050	vesicle organization
0.47	GO:0032456	endocytic recycling
0.46	GO:0042147	retrograde transport, endosome to Golgi
0.45	GO:0048278	vesicle docking
0.44	GO:1903827	regulation of cellular protein localization

0.72	GO:0005484	SNAP receptor activity
0.49	GO:0000149	SNARE binding

0.49	GO:0031201	SNARE complex
0.48	GO:0032588	trans-Golgi network membrane
0.47	GO:0045335	phagocytic vesicle
0.46	GO:0005769	early endosome
0.46	GO:0048471	perinuclear region of cytoplasm
0.43	GO:0005654	nucleoplasm
0.42	GO:0005829	cytosol
0.38	GO:0098793	presynapse
0.35	GO:0099501	exocytic vesicle membrane
0.35	GO:0044306	neuron projection terminus

tr|T1FYW8|T1FYW8_HELRO
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
Search

0.71	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

0.69	GO:0006633	fatty acid biosynthetic process
0.46	GO:0000038	very long-chain fatty acid metabolic process
0.45	GO:0030148	sphingolipid biosynthetic process
0.33	GO:0043043	peptide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process
0.32	GO:0010467	gene expression
0.32	GO:0009059	macromolecule biosynthetic process

0.85	GO:0102158	very-long-chain 3-hydroxyacyl-CoA dehydratase activity
0.85	GO:0102343	3-hydroxy-arachidoyl-CoA dehydratase activity
0.85	GO:0102345	3-hydroxy-lignoceroyl-CoA dehydratase activity
0.85	GO:0102344	3-hydroxy-behenoyl-CoA dehydratase activity
0.48	GO:0018812	3-hydroxyacyl-CoA dehydratase activity
0.38	GO:0080023	3R-hydroxyacyl-CoA dehydratase activity
0.36	GO:0019899	enzyme binding
0.34	GO:0004725	protein tyrosine phosphatase activity
0.33	GO:0003735	structural constituent of ribosome

0.71	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

0.85

EC:4.2.1.134

GO:0102343

tr|T1FYW9|T1FYW9_HELRO
Uncharacterized protein
Search

0.44	GO:0070896	positive regulation of transposon integration
0.44	GO:0016348	imaginal disc-derived leg joint morphogenesis
0.43	GO:0018992	germ-line sex determination
0.43	GO:0035017	cuticle pattern formation
0.43	GO:0048067	cuticle pigmentation
0.43	GO:0035316	non-sensory hair organization
0.43	GO:0008343	adult feeding behavior
0.41	GO:0000122	negative regulation of transcription by RNA polymerase II
0.40	GO:0045944	positive regulation of transcription by RNA polymerase II
0.39	GO:0007010	cytoskeleton organization

0.51	GO:0003676	nucleic acid binding
0.36	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.33	GO:0046872	metal ion binding

0.38	GO:0005634	nucleus
0.33	GO:0043233	organelle lumen
0.32	GO:0044446	intracellular organelle part
0.32	GO:0005737	cytoplasm

tr|T1FYX0|T1FYX0_HELRO
Uncharacterized protein
Search

0.11	Putative syntaxin-binding protein 2 (Fragment)

0.37	GO:0006904	vesicle docking involved in exocytosis
0.35	GO:0070647	protein modification by small protein conjugation or removal
0.34	GO:0002084	protein depalmitoylation
0.34	GO:0006270	DNA replication initiation
0.34	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0007018	microtubule-based movement
0.33	GO:0006633	fatty acid biosynthetic process
0.33	GO:0006508	proteolysis
0.32	GO:0006351	transcription, DNA-templated
0.32	GO:0006355	regulation of transcription, DNA-templated

0.34	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.34	GO:0005515	protein binding
0.34	GO:0008474	palmitoyl-(protein) hydrolase activity
0.34	GO:0004842	ubiquitin-protein transferase activity
0.34	GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity
0.34	GO:0102336	3-oxo-arachidoyl-CoA synthase activity
0.34	GO:0102338	3-oxo-lignoceronyl-CoA synthase activity
0.34	GO:0102337	3-oxo-cerotoyl-CoA synthase activity
0.34	GO:0044877	macromolecular complex binding
0.33	GO:0017076	purine nucleotide binding

0.34	GO:0005764	lysosome
0.34	GO:0030008	TRAPP complex
0.33	GO:0005874	microtubule
0.33	GO:0009507	chloroplast
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.34	EC:3.1.2.22	GO:0008474
0.34	KEGG:R03876	GO:0004842

tr|T1FYX1|T1FYX1_HELRO
Uncharacterized protein
Search

0.89	Potassium voltage-gated channel interacting protein 4

0.47	GO:0045163	clustering of voltage-gated potassium channels
0.46	GO:0097623	potassium ion export across plasma membrane
0.45	GO:0086009	membrane repolarization
0.41	GO:0031018	endocrine pancreas development
0.39	GO:0065009	regulation of molecular function
0.34	GO:0005513	detection of calcium ion
0.34	GO:0086001	cardiac muscle cell action potential
0.34	GO:0061337	cardiac conduction
0.34	GO:1901379	regulation of potassium ion transmembrane transport
0.34	GO:0006936	muscle contraction

0.70	GO:0005509	calcium ion binding
0.46	GO:0005250	A-type (transient outward) potassium channel activity
0.45	GO:0015459	potassium channel regulator activity
0.44	GO:0047485	protein N-terminus binding
0.44	GO:0044325	ion channel binding
0.34	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
0.34	GO:0046923	ER retention sequence binding
0.33	GO:0042802	identical protein binding

0.42	GO:0008076	voltage-gated potassium channel complex
0.35	GO:0005737	cytoplasm

tr|T1FYX2|T1FYX2_HELRO
Uncharacterized protein
Search

TRMT12

0.81	tRNA wybutosine-synthesizing protein 2

0.61	GO:0008033	tRNA processing
0.37	GO:0032259	methylation
0.37	GO:0031590	wybutosine metabolic process
0.35	GO:1901659	glycosyl compound biosynthetic process
0.34	GO:0009451	RNA modification
0.33	GO:1901566	organonitrogen compound biosynthetic process
0.31	GO:0044260	cellular macromolecule metabolic process

0.51	GO:0016740	transferase activity
0.40	GO:0140101	catalytic activity, acting on a tRNA
0.34	GO:0005515	protein binding

0.32	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.51

GO:0016740

tr|T1FYX3|T1FYX3_HELRO
Uncharacterized protein
Search

tr|T1FYX4|T1FYX4_HELRO
Uncharacterized protein
Search

0.56	Double zinc ribbon and ankyrin repeat domains 1

0.70	GO:0042462	eye photoreceptor cell development
0.38	GO:0016567	protein ubiquitination

0.49	GO:0005544	calcium-dependent phospholipid binding
0.45	GO:0005509	calcium ion binding
0.38	GO:0004842	ubiquitin-protein transferase activity

0.37	GO:0005829	cytosol
0.36	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.38

GO:0004842

tr|T1FYX5|T1FYX5_HELRO
Uncharacterized protein
Search

RIT2

0.68	GTP-binding protein RAD

0.70	GO:1901841	regulation of high voltage-gated calcium channel activity
0.63	GO:1901386	negative regulation of voltage-gated calcium channel activity
0.58	GO:0007165	signal transduction
0.39	GO:0032489	regulation of Cdc42 protein signal transduction
0.38	GO:0010976	positive regulation of neuron projection development
0.38	GO:0030100	regulation of endocytosis
0.38	GO:0010977	negative regulation of neuron projection development
0.38	GO:0032507	maintenance of protein location in cell
0.36	GO:0045944	positive regulation of transcription by RNA polymerase II
0.36	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0005246	calcium channel regulator activity
0.39	GO:0030215	semaphorin receptor binding
0.39	GO:0005516	calmodulin binding
0.37	GO:0003682	chromatin binding
0.35	GO:0005509	calcium ion binding

0.38	GO:0045121	membrane raft
0.37	GO:0043005	neuron projection
0.37	GO:0044297	cell body
0.37	GO:0036477	somatodendritic compartment
0.36	GO:0043231	intracellular membrane-bounded organelle
0.35	GO:0005886	plasma membrane
0.35	GO:0005829	cytosol
0.35	GO:0012505	endomembrane system
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0031301	integral component of organelle membrane

tr|T1FYX6|T1FYX6_HELRO
Uncharacterized protein
Search

MGST3

0.88	Microsomal glutathione S-transferase

0.53	GO:0019370	leukotriene biosynthetic process
0.46	GO:0098869	cellular oxidant detoxification
0.43	GO:0006629	lipid metabolic process
0.37	GO:0010243	response to organonitrogen compound
0.35	GO:1901685	glutathione derivative metabolic process
0.34	GO:0006805	xenobiotic metabolic process
0.33	GO:0044272	sulfur compound biosynthetic process
0.32	GO:1901566	organonitrogen compound biosynthetic process

0.54	GO:0004464	leukotriene-C4 synthase activity
0.50	GO:0004602	glutathione peroxidase activity
0.48	GO:0016740	transferase activity
0.33	GO:0005515	protein binding

0.42	GO:0005635	nuclear envelope
0.40	GO:0005783	endoplasmic reticulum
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0070062	extracellular exosome
0.35	GO:0031984	organelle subcompartment
0.34	GO:0031090	organelle membrane
0.30	GO:0016021	integral component of membrane

0.54	EC:4.4.1.20	GO:0004464
0.54	KEGG:R03059	GO:0004464

tr|T1FYX7|T1FYX7_HELRO
Uncharacterized protein
Search

0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:0010468	regulation of gene expression
0.40	GO:0010906	regulation of glucose metabolic process
0.40	GO:0043467	regulation of generation of precursor metabolites and energy
0.39	GO:0032501	multicellular organismal process
0.37	GO:0006629	lipid metabolic process
0.36	GO:0048856	anatomical structure development

0.63	GO:0043565	sequence-specific DNA binding
0.34	GO:0004000	adenosine deaminase activity
0.33	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.34

EC:3.5.4.4

GO:0004000

tr|T1FYX8|T1FYX8_HELRO
Uncharacterized protein
Search

0.60

GO:0005975

carbohydrate metabolic process

0.66	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.36	GO:0030246	carbohydrate binding

0.30

GO:0031224

intrinsic component of membrane

0.66

GO:0004553

tr|T1FYX9|T1FYX9_HELRO
Uncharacterized protein
Search

0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.55	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
0.53	GO:0060271	cilium assembly
0.52	GO:0030334	regulation of cell migration
0.45	GO:1903387	positive regulation of homophilic cell adhesion
0.44	GO:0061357	positive regulation of Wnt protein secretion
0.44	GO:2000643	positive regulation of early endosome to late endosome transport
0.43	GO:1903393	positive regulation of adherens junction organization
0.43	GO:0045022	early endosome to late endosome transport
0.42	GO:0032456	endocytic recycling

0.75	GO:0004725	protein tyrosine phosphatase activity
0.43	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding
0.41	GO:0019901	protein kinase binding
0.34	GO:0030507	spectrin binding
0.33	GO:0044389	ubiquitin-like protein ligase binding
0.33	GO:0019198	transmembrane receptor protein phosphatase activity
0.33	GO:0008134	transcription factor binding
0.33	GO:0050254	rhodopsin kinase activity

0.50	GO:0005856	cytoskeleton
0.43	GO:0120025	plasma membrane bounded cell projection
0.41	GO:0005769	early endosome
0.41	GO:0031252	cell leading edge
0.40	GO:0016604	nuclear body
0.39	GO:0044463	cell projection part
0.39	GO:0005829	cytosol
0.36	GO:0005886	plasma membrane
0.34	GO:0070062	extracellular exosome
0.34	GO:0043235	receptor complex

0.75

GO:0004725

tr|T1FYY0|T1FYY0_HELRO
Uncharacterized protein
Search

0.86	GO:0051106	positive regulation of DNA ligation
0.84	GO:0000012	single strand break repair
0.72	GO:0006302	double-strand break repair
0.63	GO:0045191	regulation of isotype switching
0.61	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.36	GO:0007165	signal transduction
0.36	GO:1903506	regulation of nucleic acid-templated transcription
0.36	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.36	GO:0034220	ion transmembrane transport
0.36	GO:0010468	regulation of gene expression

0.73	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
0.69	GO:0004520	endodeoxyribonuclease activity
0.69	GO:0008408	3'-5' exonuclease activity
0.51	GO:0000166	nucleotide binding
0.39	GO:0005230	extracellular ligand-gated ion channel activity
0.38	GO:0004888	transmembrane signaling receptor activity
0.36	GO:0046872	metal ion binding
0.36	GO:0005515	protein binding
0.36	GO:0008081	phosphoric diester hydrolase activity
0.35	GO:0003677	DNA binding

0.79	GO:0035861	site of double-strand break
0.66	GO:0005654	nucleoplasm
0.40	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.73

EC:4.2.99.18

GO:0003906

tr|T1FYY1|T1FYY1_HELRO
Uncharacterized protein
Search

0.69	Fucose-1-phosphate guanylyltransferase

0.34	GO:0006979	response to oxidative stress
0.34	GO:0016310	phosphorylation
0.34	GO:0098869	cellular oxidant detoxification
0.34	GO:1903779	regulation of cardiac conduction
0.34	GO:0002027	regulation of heart rate
0.33	GO:0036211	protein modification process
0.33	GO:0055114	oxidation-reduction process
0.33	GO:0044267	cellular protein metabolic process
0.32	GO:0035556	intracellular signal transduction

0.57	GO:0016772	transferase activity, transferring phosphorus-containing groups
0.34	GO:0032550	purine ribonucleoside binding
0.34	GO:0032561	guanyl ribonucleotide binding
0.34	GO:0004601	peroxidase activity
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0020037	heme binding
0.33	GO:0140096	catalytic activity, acting on a protein
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0004871	signal transducer activity
0.32	GO:0008144	drug binding

0.33	GO:0005737	cytoplasm
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.32	GO:0005634	nucleus

0.57	EC:2.7	GO:0016772
0.34	KEGG:R03532	GO:0004601

tr|T1FYY2|T1FYY2_HELRO
Uncharacterized protein
Search

PLAA

0.65	Ubiquitin homeostasis protein lub1

0.77	GO:0010992	ubiquitin recycling
0.68	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.57	GO:0016236	macroautophagy
0.55	GO:0032430	positive regulation of phospholipase A2 activity
0.55	GO:1900045	negative regulation of protein K63-linked ubiquitination
0.55	GO:1903423	positive regulation of synaptic vesicle recycling
0.54	GO:2001224	positive regulation of neuron migration
0.53	GO:1903861	positive regulation of dendrite extension
0.52	GO:0006692	prostanoid metabolic process
0.51	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

0.71	GO:0043130	ubiquitin binding
0.49	GO:0016005	phospholipase A2 activator activity
0.45	GO:0008235	metalloexopeptidase activity
0.45	GO:0030145	manganese ion binding
0.44	GO:0004177	aminopeptidase activity
0.44	GO:0016905	myosin heavy chain kinase activity
0.41	GO:0000906	6,7-dimethyl-8-ribityllumazine synthase activity
0.41	GO:0004665	prephenate dehydrogenase (NADP+) activity
0.41	GO:0008977	prephenate dehydrogenase (NAD+) activity

0.56	GO:0005634	nucleus
0.48	GO:0045202	synapse
0.47	GO:0005737	cytoplasm
0.44	GO:0070062	extracellular exosome
0.43	GO:0030054	cell junction
0.40	GO:0009349	riboflavin synthase complex
0.30	GO:0016020	membrane

0.44	EC:3.4.11	GO:0004177
0.41	KEGG:R01730	GO:0004665

tr|T1FYY3|T1FYY3_HELRO
Uncharacterized protein
Search

MRPS35

0.80	Mitochondrial ribosomal protein S35

0.36	GO:0007018	microtubule-based movement
0.36	GO:0006302	double-strand break repair
0.35	GO:0032543	mitochondrial translation
0.35	GO:0006310	DNA recombination
0.34	GO:0006289	nucleotide-excision repair
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression

0.38	GO:0003735	structural constituent of ribosome
0.36	GO:0003777	microtubule motor activity
0.36	GO:0008017	microtubule binding
0.34	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0003677	DNA binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003700	DNA binding transcription factor activity

0.59	GO:0005840	ribosome
0.40	GO:0005759	mitochondrial matrix
0.35	GO:0005634	nucleus
0.33	GO:0043234	protein complex
0.30	GO:0016020	membrane

tr|T1FYY4|T1FYY4_HELRO
Uncharacterized protein
Search

KL-2

0.97	1-beta dynein heavy-chain (Fragment)

0.74	GO:0007018	microtubule-based movement
0.38	GO:0001539	cilium or flagellum-dependent cell motility
0.37	GO:0036159	inner dynein arm assembly
0.37	GO:0007605	sensory perception of sound
0.33	GO:0048013	ephrin receptor signaling pathway

0.75	GO:0003777	microtubule motor activity
0.54	GO:0016887	ATPase activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0045503	dynein light chain binding
0.50	GO:0051959	dynein light intermediate chain binding
0.50	GO:0045505	dynein intermediate chain binding
0.34	GO:0046875	ephrin receptor binding

0.71	GO:0030286	dynein complex
0.50	GO:0005929	cilium
0.45	GO:0032838	plasma membrane bounded cell projection cytoplasm
0.36	GO:0005874	microtubule
0.30	GO:0031224	intrinsic component of membrane

0.54

GO:0016887

tr|T1FYY5|T1FYY5_HELRO
Uncharacterized protein
Search

LSM7

0.86	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated

0.78	GO:0000956	nuclear-transcribed mRNA catabolic process
0.75	GO:0000398	mRNA splicing, via spliceosome

0.39	GO:0003723	RNA binding
0.34	GO:0005515	protein binding

0.57	GO:0030529	intracellular ribonucleoprotein complex
0.47	GO:1990726	Lsm1-7-Pat1 complex
0.41	GO:0044428	nuclear part
0.40	GO:1902494	catalytic complex
0.35	GO:0019013	viral nucleocapsid
0.33	GO:0005829	cytosol
0.33	GO:0031974	membrane-enclosed lumen

tr|T1FYY6|T1FYY6_HELRO
Uncharacterized protein
Search

0.74	GO:0007018	microtubule-based movement
0.49	GO:0001539	cilium or flagellum-dependent cell motility
0.38	GO:0060271	cilium assembly
0.35	GO:0007605	sensory perception of sound
0.34	GO:0048013	ephrin receptor signaling pathway
0.34	GO:0061371	determination of heart left/right asymmetry
0.33	GO:0001578	microtubule bundle formation
0.32	GO:0043623	cellular protein complex assembly

0.75	GO:0003777	microtubule motor activity
0.57	GO:0016887	ATPase activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0045503	dynein light chain binding
0.51	GO:0051959	dynein light intermediate chain binding
0.51	GO:0045505	dynein intermediate chain binding
0.35	GO:0046875	ephrin receptor binding
0.32	GO:0005509	calcium ion binding

0.76	GO:0030286	dynein complex
0.56	GO:0005929	cilium
0.54	GO:0032838	plasma membrane bounded cell projection cytoplasm
0.35	GO:0005874	microtubule
0.30	GO:0031224	intrinsic component of membrane

0.57

GO:0016887

tr|T1FYY7|T1FYY7_HELRO
Serine/threonine-protein phosphatase
Search

PPP3CB

0.48	Serine/threonine-protein phosphatase

0.72	GO:0006470	protein dephosphorylation
0.56	GO:0097720	calcineurin-mediated signaling
0.52	GO:0001915	negative regulation of T cell mediated cytotoxicity
0.52	GO:0032844	regulation of homeostatic process
0.52	GO:0031987	locomotion involved in locomotory behavior
0.51	GO:0035690	cellular response to drug
0.51	GO:0001946	lymphangiogenesis
0.50	GO:0043029	T cell homeostasis
0.50	GO:0060341	regulation of cellular localization
0.50	GO:0035176	social behavior

0.72	GO:0004721	phosphoprotein phosphatase activity
0.56	GO:0030346	protein phosphatase 2B binding
0.51	GO:0005516	calmodulin binding
0.47	GO:0005509	calcium ion binding
0.44	GO:0046983	protein dimerization activity
0.40	GO:0008144	drug binding
0.34	GO:0019855	calcium channel inhibitor activity

0.56	GO:0005955	calcineurin complex
0.50	GO:0030315	T-tubule
0.49	GO:0030018	Z disc
0.46	GO:0120105	actomyosin contractile ring, intermediate layer
0.35	GO:0005829	cytosol
0.34	GO:0043204	perikaryon
0.34	GO:0030424	axon
0.33	GO:0005654	nucleoplasm
0.32	GO:0043234	protein complex

0.72

GO:0004721

tr|T1FYY8|T1FYY8_HELRO
Uncharacterized protein
Search

TMEM41A

0.63	Transmembrane protein 41A (inferred by orthology to a human protein)

0.36	GO:0007399	nervous system development
0.34	GO:0006597	spermine biosynthetic process
0.34	GO:0032224	positive regulation of synaptic transmission, cholinergic
0.34	GO:0008295	spermidine biosynthetic process
0.34	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.34	GO:0000904	cell morphogenesis involved in differentiation
0.33	GO:0120036	plasma membrane bounded cell projection organization
0.33	GO:0006935	chemotaxis
0.33	GO:0006928	movement of cell or subcellular component
0.32	GO:0006351	transcription, DNA-templated

0.34	GO:0004014	adenosylmethionine decarboxylase activity
0.32	GO:0003676	nucleic acid binding

0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.34	EC:4.1.1.50	GO:0004014
0.34	KEGG:R00178	GO:0004014

tr|T1FYY9|T1FYY9_HELRO
Uncharacterized protein
Search

0.57	Zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2

0.75	GO:0000398	mRNA splicing, via spliceosome
0.34	GO:0036444	mitochondrial calcium uptake
0.34	GO:0051560	mitochondrial calcium ion homeostasis

0.59	GO:0003723	RNA binding
0.54	GO:0046872	metal ion binding

0.84	GO:0089701	U2AF
0.54	GO:0019013	viral nucleocapsid
0.49	GO:0030529	intracellular ribonucleoprotein complex
0.34	GO:1990246	uniplex complex

tr|T1FYZ0|T1FYZ0_HELRO
Uncharacterized protein
Search

RSPH3

0.95	Flagellar radial spoke protein 3

0.42

GO:0005515

protein binding

0.68	GO:0042995	cell projection
0.58	GO:0005856	cytoskeleton
0.44	GO:0005737	cytoplasm

tr|T1FYZ1|T1FYZ1_HELRO
Uncharacterized protein
Search

0.81	Proto-oncogene tyrosine-protein kinase Src

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.58	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.53	GO:0042997	negative regulation of Golgi to plasma membrane protein transport
0.51	GO:0042127	regulation of cell proliferation
0.48	GO:0071310	cellular response to organic substance
0.47	GO:0007275	multicellular organism development
0.47	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway
0.47	GO:0070848	response to growth factor
0.47	GO:0046777	protein autophosphorylation
0.46	GO:0030154	cell differentiation

0.77	GO:0004713	protein tyrosine kinase activity
0.58	GO:0019199	transmembrane receptor protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0034236	protein kinase A catalytic subunit binding
0.46	GO:0042802	identical protein binding
0.42	GO:0005102	receptor binding
0.41	GO:0048407	platelet-derived growth factor binding

0.46	GO:0030054	cell junction
0.44	GO:0098552	side of membrane
0.44	GO:0005886	plasma membrane
0.42	GO:0019898	extrinsic component of membrane
0.40	GO:0005902	microvillus
0.39	GO:0009986	cell surface
0.37	GO:0035230	cytoneme
0.37	GO:0098857	membrane microdomain
0.36	GO:0005634	nucleus
0.35	GO:0005737	cytoplasm

0.77

GO:0004713

tr|T1FYZ2|T1FYZ2_HELRO
Uncharacterized protein
Search

CCDC103

0.78	Coiled-coil domain-containing protein 103

0.81	GO:0070286	axonemal dynein complex assembly
0.81	GO:0001947	heart looping
0.79	GO:0003341	cilium movement
0.71	GO:0003146	heart jogging
0.69	GO:0071907	determination of digestive tract left/right asymmetry

0.59

GO:0042803

protein homodimerization activity

0.74	GO:0005929	cilium
0.69	GO:0032838	plasma membrane bounded cell projection cytoplasm
0.60	GO:0044430	cytoskeletal part

tr|T1FYZ3|T1FYZ3_HELRO
Uncharacterized protein
Search

SKP1

0.85	S-phase kinase-associated protein 1

0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.51	GO:0016310	phosphorylation
0.45	GO:0010498	proteasomal protein catabolic process
0.41	GO:0035518	histone H2A monoubiquitination
0.40	GO:0051457	maintenance of protein location in nucleus
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0010265	SCF complex assembly
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:0070498	interleukin-1-mediated signaling pathway

0.53	GO:0016301	kinase activity
0.41	GO:0097602	cullin family protein binding
0.40	GO:0008013	beta-catenin binding
0.38	GO:0019904	protein domain specific binding
0.38	GO:0061630	ubiquitin protein ligase activity
0.35	GO:0004806	triglyceride lipase activity
0.35	GO:0016874	ligase activity
0.33	GO:0004721	phosphoprotein phosphatase activity

0.51	GO:0031467	Cul7-RING ubiquitin ligase complex
0.48	GO:0019005	SCF ubiquitin ligase complex
0.43	GO:0005813	centrosome
0.42	GO:0005829	cytosol
0.40	GO:0031519	PcG protein complex
0.36	GO:0070062	extracellular exosome
0.34	GO:0005654	nucleoplasm
0.30	GO:0016021	integral component of membrane

0.35

EC:3.1.1.3

GO:0004806

tr|T1FYZ4|T1FYZ4_HELRO
Uncharacterized protein
Search

0.38	GO:0006508	proteolysis
0.34	GO:0061061	muscle structure development
0.34	GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.33	GO:0006355	regulation of transcription, DNA-templated

0.52	GO:0046872	metal ion binding
0.38	GO:0008233	peptidase activity
0.33	GO:0005515	protein binding

0.45	GO:0032154	cleavage furrow
0.42	GO:0005938	cell cortex
0.38	GO:0005911	cell-cell junction
0.35	GO:0055120	striated muscle dense body
0.34	GO:0030686	90S preribosome
0.33	GO:0005730	nucleolus
0.30	GO:0031224	intrinsic component of membrane

0.38

GO:0008233

tr|T1FYZ5|T1FYZ5_HELRO
Derlin
Search

DERL1

0.67

Derlin

0.54	GO:0031648	protein destabilization
0.54	GO:0071712	ER-associated misfolded protein catabolic process
0.53	GO:1903513	endoplasmic reticulum to cytosol transport
0.53	GO:0032527	protein exit from endoplasmic reticulum
0.53	GO:0006986	response to unfolded protein
0.53	GO:0032092	positive regulation of protein binding
0.51	GO:0030433	ubiquitin-dependent ERAD pathway
0.51	GO:0031398	positive regulation of protein ubiquitination
0.50	GO:0051260	protein homooligomerization
0.43	GO:0007165	signal transduction

0.55	GO:0042288	MHC class I protein binding
0.54	GO:1990381	ubiquitin-specific protease binding
0.53	GO:0051117	ATPase binding
0.50	GO:0031625	ubiquitin protein ligase binding
0.34	GO:0003735	structural constituent of ribosome
0.33	GO:0004872	receptor activity

0.72	GO:0005789	endoplasmic reticulum membrane
0.52	GO:0005791	rough endoplasmic reticulum
0.51	GO:0005769	early endosome
0.50	GO:0005770	late endosome
0.50	GO:0048500	signal recognition particle
0.47	GO:0098588	bounding membrane of organelle
0.44	GO:0098796	membrane protein complex
0.36	GO:0097038	perinuclear endoplasmic reticulum
0.34	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

tr|T1FYZ6|T1FYZ6_HELRO
Uncharacterized protein
Search

tr|T1FYZ7|T1FYZ7_HELRO
Uncharacterized protein
Search

0.63	Putative 52 kDa repressor of the inhibitor of the protein kinase (Fragment)

0.57

GO:0016310

phosphorylation

0.68	GO:0046983	protein dimerization activity
0.59	GO:0016301	kinase activity

tr|T1FYZ8|T1FYZ8_HELRO
Uncharacterized protein
Search

0.44	Formate acetyltransferase

0.69	GO:0098869	cellular oxidant detoxification
0.53	GO:0055114	oxidation-reduction process
0.38	GO:0044341	sodium-dependent phosphate transport
0.34	GO:0032259	methylation
0.33	GO:0043043	peptide biosynthetic process
0.33	GO:0010467	gene expression
0.33	GO:0044267	cellular protein metabolic process
0.32	GO:0009451	RNA modification
0.32	GO:0009059	macromolecule biosynthetic process

0.72	GO:0004601	peroxidase activity
0.63	GO:0020037	heme binding
0.38	GO:0015321	sodium-dependent phosphate transmembrane transporter activity
0.34	GO:0008168	methyltransferase activity
0.32	GO:0140098	catalytic activity, acting on RNA

0.30

GO:0016020

membrane

0.72	EC:1.11.1.7	GO:0004601
0.72	KEGG:R03532	GO:0004601

tr|T1FYZ9|T1FYZ9_HELRO
Uncharacterized protein
Search

0.78

GO:0051568

histone H3-K4 methylation

0.75	GO:0018024	histone-lysine N-methyltransferase activity
0.54	GO:0003723	RNA binding

0.75	GO:0048188	Set1C/COMPASS complex
0.43	GO:0005829	cytosol

0.75

GO:0018024

tr|T1FZ00|T1FZ00_HELRO
Uncharacterized protein
Search

0.75	Patatin like phospholipase domain containing 6

0.77	GO:0046470	phosphatidylcholine metabolic process
0.72	GO:0016042	lipid catabolic process
0.43	GO:0032502	developmental process
0.40	GO:0034349	glial cell apoptotic process
0.39	GO:0032501	multicellular organismal process
0.39	GO:2000480	negative regulation of cAMP-dependent protein kinase activity
0.39	GO:0051402	neuron apoptotic process
0.37	GO:0060249	anatomical structure homeostasis
0.37	GO:0006643	membrane lipid metabolic process
0.37	GO:0072657	protein localization to membrane

0.80	GO:0004622	lysophospholipase activity
0.39	GO:0034236	protein kinase A catalytic subunit binding
0.34	GO:0030507	spectrin binding
0.34	GO:0005516	calmodulin binding
0.33	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.33	GO:0008017	microtubule binding

0.46	GO:0005783	endoplasmic reticulum
0.39	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.38	GO:0031984	organelle subcompartment
0.35	GO:0005765	lysosomal membrane
0.35	GO:0031965	nuclear membrane
0.34	GO:0005886	plasma membrane
0.34	GO:0031966	mitochondrial membrane
0.33	GO:0005874	microtubule
0.30	GO:0016021	integral component of membrane

0.80

EC:3.1.1.5

GO:0004622

tr|T1FZ01|T1FZ01_HELRO
Uncharacterized protein
Search

0.59	Dynein heavy chain axonemal

0.74	GO:0007018	microtubule-based movement
0.36	GO:0048013	ephrin receptor signaling pathway
0.36	GO:0007605	sensory perception of sound
0.35	GO:0036159	inner dynein arm assembly
0.35	GO:1902358	sulfate transmembrane transport
0.35	GO:0001539	cilium or flagellum-dependent cell motility
0.33	GO:0016310	phosphorylation

0.75	GO:0003777	microtubule motor activity
0.56	GO:0016887	ATPase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0045503	dynein light chain binding
0.47	GO:0051959	dynein light intermediate chain binding
0.47	GO:0045505	dynein intermediate chain binding
0.37	GO:0046875	ephrin receptor binding
0.35	GO:0003951	NAD+ kinase activity

0.77	GO:0030286	dynein complex
0.45	GO:0005929	cilium
0.40	GO:0032838	plasma membrane bounded cell projection cytoplasm
0.35	GO:0005874	microtubule
0.30	GO:0031224	intrinsic component of membrane

0.56	EC:3.6.1.3	GO:0016887
0.35	KEGG:R00104	GO:0003951

tr|T1FZ02|T1FZ02_HELRO
Uncharacterized protein
Search

RALGAPA2

0.61	Ral GTPase activating protein catalytic alpha subunit 2

0.76	GO:0051056	regulation of small GTPase mediated signal transduction
0.76	GO:0043547	positive regulation of GTPase activity
0.37	GO:0032484	Ral protein signal transduction
0.36	GO:0007420	brain development
0.36	GO:0060178	regulation of exocyst localization
0.33	GO:0008340	determination of adult lifespan
0.33	GO:2001141	regulation of RNA biosynthetic process
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression

0.76	GO:0005096	GTPase activator activity
0.35	GO:0046982	protein heterodimerization activity

0.61	GO:0005634	nucleus
0.41	GO:0005829	cytosol
0.38	GO:0005886	plasma membrane
0.34	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane

tr|T1FZ03|T1FZ03_HELRO
Uncharacterized protein
Search

0.77	GO:0097178	ruffle assembly
0.74	GO:0007416	synapse assembly
0.70	GO:0048812	neuron projection morphogenesis
0.68	GO:0006897	endocytosis

0.69	GO:0051015	actin filament binding
0.35	GO:0046872	metal ion binding

0.42	GO:0005622	intracellular
0.30	GO:0044425	membrane part

tr|T1FZ04|T1FZ04_HELRO
Uncharacterized protein
Search

tr|T1FZ05|T1FZ05_HELRO
Uncharacterized protein
Search

HNF4A

0.87	Hepatocyte nuclear factor 4-alpha

0.79	GO:0043401	steroid hormone mediated signaling pathway
0.67	GO:0030522	intracellular receptor signaling pathway
0.58	GO:0097659	nucleic acid-templated transcription
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:2000189	positive regulation of cholesterol homeostasis
0.54	GO:0055091	phospholipid homeostasis
0.54	GO:0010467	gene expression
0.53	GO:0070328	triglyceride homeostasis

0.80	GO:0003707	steroid hormone receptor activity
0.69	GO:0004879	nuclear receptor activity
0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.53	GO:0005504	fatty acid binding
0.53	GO:0001102	RNA polymerase II activating transcription factor binding
0.52	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.50	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.50	GO:0001012	RNA polymerase II regulatory region DNA binding
0.48	GO:0042803	protein homodimerization activity

0.61	GO:0005634	nucleus
0.45	GO:0070013	intracellular organelle lumen
0.41	GO:0044446	intracellular organelle part
0.38	GO:0005737	cytoplasm

0.35

EC:3.1.2.2

GO:0016290

tr|T1FZ06|T1FZ06_HELRO
Uncharacterized protein
Search

0.67	Tyrosine-protein phosphatase non-receptor type 23 (Fragment)

0.72	GO:0035335	peptidyl-tyrosine dephosphorylation
0.66	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
0.63	GO:0060271	cilium assembly
0.62	GO:0030334	regulation of cell migration
0.57	GO:0061357	positive regulation of Wnt protein secretion
0.57	GO:1903387	positive regulation of homophilic cell adhesion
0.56	GO:0045022	early endosome to late endosome transport
0.55	GO:2000643	positive regulation of early endosome to late endosome transport
0.54	GO:0032456	endocytic recycling
0.54	GO:1903393	positive regulation of adherens junction organization

0.73	GO:0004725	protein tyrosine phosphatase activity
0.50	GO:0019901	protein kinase binding
0.35	GO:0050254	rhodopsin kinase activity
0.34	GO:0003779	actin binding

0.51	GO:0036064	ciliary basal body
0.50	GO:0005769	early endosome
0.49	GO:0016604	nuclear body
0.47	GO:0005829	cytosol
0.34	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.73

GO:0004725

tr|T1FZ07|T1FZ07_HELRO
Uncharacterized protein
Search

0.70	Biogenesis of lysosome-related organelles complex 1 subunit 2

tr|T1FZ08|T1FZ08_HELRO
DNA helicase
Search

MCM4

0.43	DNA helicase

0.75	GO:0006270	DNA replication initiation
0.69	GO:0032392	DNA geometric change
0.44	GO:0001878	response to yeast

0.70	GO:0003678	DNA helicase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0003677	DNA binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0070035	purine NTP-dependent helicase activity
0.46	GO:0008094	DNA-dependent ATPase activity
0.41	GO:0003682	chromatin binding

0.79	GO:0042555	MCM complex
0.61	GO:0005634	nucleus
0.45	GO:0031974	membrane-enclosed lumen
0.41	GO:0044446	intracellular organelle part
0.33	GO:0005694	chromosome
0.30	GO:0016020	membrane

tr|T1FZ09|T1FZ09_HELRO
Uncharacterized protein
Search

USP6NL

0.81	Putative ubiquitin carboxyl-terminal hydrolase 6

0.69	GO:0035526	retrograde transport, plasma membrane to Golgi
0.67	GO:0048227	plasma membrane to endosome transport
0.67	GO:1903358	regulation of Golgi organization
0.66	GO:0043547	positive regulation of GTPase activity
0.65	GO:0031338	regulation of vesicle fusion
0.62	GO:0007030	Golgi organization
0.55	GO:0006886	intracellular protein transport
0.55	GO:0019068	virion assembly

0.71	GO:0017137	Rab GTPase binding
0.67	GO:0005096	GTPase activator activity
0.42	GO:0016787	hydrolase activity
0.35	GO:0003723	RNA binding

0.56	GO:0031410	cytoplasmic vesicle
0.54	GO:0012505	endomembrane system
0.45	GO:0005886	plasma membrane
0.35	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

0.42

GO:0016787

tr|T1FZ10|T1FZ10_HELRO
Uncharacterized protein
Search

0.10	Intersectin-1 (Fragment)

0.70	GO:0035023	regulation of Rho protein signal transduction
0.61	GO:0065009	regulation of molecular function
0.56	GO:0035556	intracellular signal transduction
0.50	GO:0051897	positive regulation of protein kinase B signaling
0.50	GO:0043524	negative regulation of neuron apoptotic process
0.47	GO:0042327	positive regulation of phosphorylation
0.40	GO:0006897	endocytosis
0.37	GO:2001288	positive regulation of caveolin-mediated endocytosis
0.36	GO:0060124	positive regulation of growth hormone secretion
0.36	GO:0060999	positive regulation of dendritic spine development

0.71	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.68	GO:0005509	calcium ion binding
0.53	GO:0070064	proline-rich region binding
0.50	GO:0032947	protein complex scaffold activity
0.49	GO:0019209	kinase activator activity

0.50	GO:0005905	clathrin-coated pit
0.49	GO:0030027	lamellipodium
0.49	GO:0030139	endocytic vesicle
0.40	GO:0005886	plasma membrane
0.38	GO:0043005	neuron projection
0.38	GO:0045202	synapse
0.38	GO:0030054	cell junction
0.35	GO:0005829	cytosol
0.35	GO:0043025	neuronal cell body
0.35	GO:0120038	plasma membrane bounded cell projection part

tr|T1FZ11|T1FZ11_HELRO
Uncharacterized protein
Search

AGBL2

0.57	Cytosolic carboxypeptidase 3

0.61	GO:0006508	proteolysis
0.61	GO:0035610	protein side chain deglutamylation
0.35	GO:0006936	muscle contraction
0.32	GO:0006468	protein phosphorylation

0.78	GO:0004181	metallocarboxypeptidase activity
0.63	GO:0008270	zinc ion binding
0.36	GO:0017022	myosin binding
0.35	GO:0005516	calmodulin binding
0.35	GO:0003779	actin binding
0.34	GO:0031492	nucleosomal DNA binding
0.32	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding

0.48	GO:0036064	ciliary basal body
0.48	GO:0005814	centriole
0.45	GO:0005829	cytosol
0.35	GO:0031514	motile cilium
0.33	GO:0000785	chromatin
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.78

EC:3.4.17

GO:0004181

tr|T1FZ12|T1FZ12_HELRO
Uncharacterized protein
Search

0.95	Nuclear receptor subfamily 1 group D variant 2 (Fragment)

0.78	GO:0043401	steroid hormone mediated signaling pathway
0.75	GO:0030522	intracellular receptor signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.37	GO:0007553	regulation of ecdysteroid metabolic process
0.37	GO:0018990	ecdysis, chitin-based cuticle
0.36	GO:0035075	response to ecdysone
0.36	GO:0019730	antimicrobial humoral response

0.81	GO:0004887	thyroid hormone receptor activity
0.79	GO:0003707	steroid hormone receptor activity
0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.34	GO:0020037	heme binding

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1FZ13|T1FZ13_HELRO
Uncharacterized protein
Search

tr|T1FZ14|T1FZ14_HELRO
Uncharacterized protein
Search

0.64	GO:0043401	steroid hormone mediated signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.47	GO:0030522	intracellular receptor signaling pathway
0.41	GO:1902680	positive regulation of RNA biosynthetic process
0.41	GO:1902679	negative regulation of RNA biosynthetic process
0.36	GO:0042738	exogenous drug catabolic process
0.36	GO:0071305	cellular response to vitamin D

0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.58	GO:0003707	steroid hormone receptor activity
0.42	GO:0001012	RNA polymerase II regulatory region DNA binding
0.41	GO:0003690	double-stranded DNA binding
0.35	GO:0005496	steroid binding
0.34	GO:0038186	lithocholic acid receptor activity
0.33	GO:0003713	transcription coactivator activity
0.33	GO:0046965	retinoid X receptor binding

0.61	GO:0005634	nucleus
0.40	GO:0043233	organelle lumen
0.39	GO:0005829	cytosol
0.37	GO:0044446	intracellular organelle part
0.37	GO:0005856	cytoskeleton
0.33	GO:0043235	receptor complex
0.33	GO:0005667	transcription factor complex
0.30	GO:0016020	membrane

0.33

EC:1.97.1

GO:0051353

tr|T1FZ15|T1FZ15_HELRO
Uncharacterized protein
Search

0.61	Voltage-dependent calcium channel subunit alpha-2/delta-4

0.78	GO:0050908	detection of light stimulus involved in visual perception
0.69	GO:0070588	calcium ion transmembrane transport
0.45	GO:0034765	regulation of ion transmembrane transport
0.40	GO:0061337	cardiac conduction
0.37	GO:0065009	regulation of molecular function

0.73	GO:0005245	voltage-gated calcium channel activity
0.40	GO:0005246	calcium channel regulator activity
0.38	GO:0046872	metal ion binding

0.73

GO:0005891

voltage-gated calcium channel complex

tr|T1FZ16|T1FZ16_HELRO
Uncharacterized protein
Search

0.65	GO:0007275	multicellular organism development
0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.51	GO:2000648	positive regulation of stem cell proliferation
0.51	GO:2000179	positive regulation of neural precursor cell proliferation
0.50	GO:0060322	head development
0.48	GO:0010720	positive regulation of cell development
0.48	GO:0051962	positive regulation of nervous system development
0.47	GO:0030154	cell differentiation

0.62

GO:0043565

sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1FZ17|T1FZ17_HELRO
Uncharacterized protein
Search

BPTF

0.68	Bromodomain PHD finger transcription factor

0.45	GO:0006325	chromatin organization
0.44	GO:0045893	positive regulation of transcription, DNA-templated
0.44	GO:0009952	anterior/posterior pattern specification
0.44	GO:0007420	brain development
0.43	GO:0048568	embryonic organ development
0.43	GO:0043009	chordate embryonic development
0.43	GO:0061187	regulation of chromatin silencing at rDNA
0.42	GO:0006482	protein demethylation
0.42	GO:0007492	endoderm development
0.42	GO:0045815	positive regulation of gene expression, epigenetic

0.75	GO:0140034	methylation-dependent protein binding
0.71	GO:0042393	histone binding
0.53	GO:0046872	metal ion binding
0.44	GO:0045322	unmethylated CpG binding
0.44	GO:0051864	histone demethylase activity (H3-K36 specific)
0.44	GO:0035575	histone demethylase activity (H4-K20 specific)
0.43	GO:0032454	histone demethylase activity (H3-K9 specific)
0.42	GO:0071558	histone demethylase activity (H3-K27 specific)
0.41	GO:0008168	methyltransferase activity
0.40	GO:0003682	chromatin binding

0.73	GO:0016589	NURF complex
0.47	GO:0048188	Set1C/COMPASS complex
0.40	GO:0031965	nuclear membrane
0.39	GO:0005730	nucleolus
0.36	GO:0070062	extracellular exosome
0.36	GO:0030425	dendrite
0.36	GO:0044297	cell body
0.36	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0016021	integral component of membrane

0.44

EC:1.14.11.27

GO:0051864

tr|T1FZ18|T1FZ18_HELRO
Uncharacterized protein
Search

0.52	LIM homeobox 5

0.65	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
0.64	GO:0021527	spinal cord association neuron differentiation
0.64	GO:0021702	cerebellar Purkinje cell differentiation
0.59	GO:0030900	forebrain development
0.57	GO:2000744	positive regulation of anterior head development
0.57	GO:0097477	lateral motor column neuron migration
0.57	GO:2000768	positive regulation of nephron tubule epithelial cell differentiation
0.57	GO:0061205	paramesonephric duct development
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process

0.65	GO:0043565	sequence-specific DNA binding
0.53	GO:0046872	metal ion binding
0.43	GO:0003700	DNA binding transcription factor activity
0.43	GO:0003714	transcription corepressor activity
0.35	GO:0005515	protein binding
0.34	GO:0035326	enhancer binding
0.33	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.43	GO:0043234	protein complex
0.30	GO:0016020	membrane

tr|T1FZ19|T1FZ19_HELRO
Uncharacterized protein
Search

ABHD18

0.90	Abhydrolase domain containing 18

0.47	GO:0050909	sensory perception of taste
0.44	GO:0007186	G-protein coupled receptor signaling pathway

0.44

GO:0004930

G-protein coupled receptor activity

0.53	GO:0005576	extracellular region
0.30	GO:0044425	membrane part

tr|T1FZ20|T1FZ20_HELRO
Uncharacterized protein
Search

0.92	E3 ubiquitin-protein ligase DTX1 (Fragment)

0.50	GO:0007219	Notch signaling pathway
0.37	GO:0045581	negative regulation of T cell differentiation
0.37	GO:0008593	regulation of Notch signaling pathway
0.37	GO:0045665	negative regulation of neuron differentiation
0.37	GO:1990823	response to leukemia inhibitory factor
0.37	GO:0010001	glial cell differentiation
0.36	GO:0071345	cellular response to cytokine stimulus
0.34	GO:0016567	protein ubiquitination

0.60	GO:0008270	zinc ion binding
0.50	GO:0016874	ligase activity
0.37	GO:0005112	Notch binding
0.37	GO:0031625	ubiquitin protein ligase binding
0.32	GO:0016740	transferase activity

0.47	GO:0031965	nuclear membrane
0.44	GO:0005654	nucleoplasm
0.35	GO:0005829	cytosol
0.34	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

0.50

GO:0016874

tr|T1FZ21|T1FZ21_HELRO
Uncharacterized protein
Search

SHOX2

0.90	Short stature homeobox transcript variant SHOXa

0.64	GO:0007275	multicellular organism development
0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.52	GO:2000172	regulation of branching morphogenesis of a nerve
0.52	GO:0048743	positive regulation of skeletal muscle fiber development
0.51	GO:0002053	positive regulation of mesenchymal cell proliferation
0.50	GO:0045880	positive regulation of smoothened signaling pathway
0.50	GO:0032330	regulation of chondrocyte differentiation
0.50	GO:0001649	osteoblast differentiation

0.63	GO:0043565	sequence-specific DNA binding
0.34	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.33	GO:0043233	organelle lumen
0.32	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

tr|T1FZ22|T1FZ22_HELRO
Uncharacterized protein
Search

0.72	membrane-associated phosphatidylinositol transfer protein 1

0.79	GO:0015914	phospholipid transport
0.45	GO:0048015	phosphatidylinositol-mediated signaling
0.33	GO:0006661	phosphatidylinositol biosynthetic process
0.33	GO:0006508	proteolysis

0.80	GO:0005548	phospholipid transporter activity
0.53	GO:0030971	receptor tyrosine kinase binding
0.53	GO:0046872	metal ion binding
0.48	GO:0031210	phosphatidylcholine binding
0.48	GO:0070300	phosphatidic acid binding
0.44	GO:0035091	phosphatidylinositol binding
0.35	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.32	GO:0003676	nucleic acid binding
0.32	GO:0016740	transferase activity

0.45	GO:0005622	intracellular
0.39	GO:1990904	ribonucleoprotein complex
0.39	GO:0043228	non-membrane-bounded organelle
0.38	GO:0044422	organelle part
0.36	GO:0044297	cell body
0.34	GO:0012505	endomembrane system
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016740

tr|T1FZ23|T1FZ23_HELRO
Uncharacterized protein
Search

PSKH1

0.68	Serine/threonine-protein kinase H1

0.63	GO:0006468	protein phosphorylation
0.54	GO:0007368	determination of left/right symmetry
0.52	GO:0007507	heart development
0.49	GO:0018210	peptidyl-threonine modification
0.48	GO:0018209	peptidyl-serine modification
0.42	GO:0035556	intracellular signal transduction

0.67	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding

0.48	GO:0005654	nucleoplasm
0.36	GO:0005815	microtubule organizing center
0.36	GO:0005789	endoplasmic reticulum membrane
0.36	GO:0005794	Golgi apparatus
0.34	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.67

GO:0004674

tr|T1FZ24|T1FZ24_HELRO
Uncharacterized protein
Search

0.37	Putative syntaxin-binding protein 2 (Fragment)

0.36	GO:0070647	protein modification by small protein conjugation or removal
0.35	GO:0070143	mitochondrial alanyl-tRNA aminoacylation
0.34	GO:0009190	cyclic nucleotide biosynthetic process
0.34	GO:0006508	proteolysis
0.34	GO:0007165	signal transduction
0.33	GO:0060078	regulation of postsynaptic membrane potential
0.33	GO:0006355	regulation of transcription, DNA-templated
0.33	GO:0007268	chemical synaptic transmission
0.33	GO:0006351	transcription, DNA-templated
0.32	GO:0007275	multicellular organism development

0.35	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.35	GO:0017056	structural constituent of nuclear pore
0.34	GO:0004842	ubiquitin-protein transferase activity
0.34	GO:0008270	zinc ion binding
0.34	GO:0004813	alanine-tRNA ligase activity
0.34	GO:0016849	phosphorus-oxygen lyase activity
0.34	GO:0004983	neuropeptide Y receptor activity
0.34	GO:0008080	N-acetyltransferase activity
0.33	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor
0.33	GO:0022848	acetylcholine-gated cation-selective channel activity

0.35	GO:0005643	nuclear pore
0.33	GO:0044444	cytoplasmic part
0.33	GO:0045211	postsynaptic membrane
0.33	GO:0030054	cell junction
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane

0.34	EC:6.1.1.7	GO:0004813
0.34	KEGG:R03876	GO:0004842

tr|T1FZ25|T1FZ25_HELRO
Uncharacterized protein
Search

0.84	Zinc finger protein sens

0.58	GO:0051569	regulation of histone H3-K4 methylation
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0030097	hemopoiesis
0.46	GO:0016360	sensory organ precursor cell fate determination
0.45	GO:0008594	photoreceptor cell morphogenesis
0.45	GO:0008407	chaeta morphogenesis
0.45	GO:0042051	compound eye photoreceptor development
0.44	GO:0007422	peripheral nervous system development

0.51	GO:0003676	nucleic acid binding
0.45	GO:0043425	bHLH transcription factor binding
0.44	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.43	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.36	GO:0008013	beta-catenin binding
0.34	GO:0001085	RNA polymerase II transcription factor binding
0.33	GO:0003707	steroid hormone receptor activity
0.33	GO:0046872	metal ion binding

0.44	GO:0005700	polytene chromosome
0.39	GO:0005634	nucleus
0.34	GO:0005667	transcription factor complex
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZ26|T1FZ26_HELRO
Uncharacterized protein
Search

0.44	Putative conserved plasma membrane protein (Fragment)

0.30

GO:0044425

membrane part

tr|T1FZ27|T1FZ27_HELRO
Uncharacterized protein
Search

DCAF1

0.87	DDB1 and CUL4 associated factor 1

0.76	GO:1990245	histone H2A-T120 phosphorylation
0.73	GO:0035212	cell competition in a multicellular organism
0.73	GO:0016567	protein ubiquitination
0.67	GO:0030183	B cell differentiation
0.63	GO:0000122	negative regulation of transcription by RNA polymerase II
0.62	GO:0033151	V(D)J recombination

0.76	GO:1990244	histone kinase activity (H2A-T120 specific)
0.71	GO:0030331	estrogen receptor binding

0.68	GO:0080008	Cul4-RING E3 ubiquitin ligase complex
0.67	GO:0001650	fibrillar center
0.66	GO:0008180	COP9 signalosome
0.30	GO:0016020	membrane

tr|T1FZ28|T1FZ28_HELRO
Uncharacterized protein
Search

0.80	GO:0001558	regulation of cell growth
0.52	GO:0035988	chondrocyte proliferation
0.52	GO:0001502	cartilage condensation
0.52	GO:0061035	regulation of cartilage development
0.51	GO:0051496	positive regulation of stress fiber assembly
0.50	GO:0001503	ossification
0.50	GO:0001525	angiogenesis
0.50	GO:0070372	regulation of ERK1 and ERK2 cascade
0.50	GO:0007155	cell adhesion
0.50	GO:0030324	lung development

0.84	GO:0005520	insulin-like growth factor binding
0.56	GO:0005178	integrin binding
0.54	GO:0008201	heparin binding
0.49	GO:0008022	protein C-terminus binding
0.39	GO:0008083	growth factor activity
0.38	GO:0001968	fibronectin binding
0.37	GO:0050840	extracellular matrix binding
0.35	GO:0005112	Notch binding
0.34	GO:0019904	protein domain specific binding

0.66	GO:0005576	extracellular region
0.37	GO:0005801	cis-Golgi network
0.36	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0005938	cell cortex
0.35	GO:0005829	cytosol
0.35	GO:0031982	vesicle
0.34	GO:0005921	gap junction
0.34	GO:0009986	cell surface
0.33	GO:0005886	plasma membrane

tr|T1FZ29|T1FZ29_HELRO
Uncharacterized protein
Search

0.58	ADP-ribosylation factor

0.35	GO:0051489	regulation of filopodium assembly
0.35	GO:0000281	mitotic cytokinesis
0.34	GO:0016192	vesicle-mediated transport
0.34	GO:0015031	protein transport
0.34	GO:0006471	protein ADP-ribosylation
0.33	GO:0007281	germ cell development
0.33	GO:0009792	embryo development ending in birth or egg hatching
0.32	GO:0055085	transmembrane transport

0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0005515	protein binding
0.32	GO:0022803	passive transmembrane transporter activity
0.32	GO:0003677	DNA binding

0.45	GO:0005622	intracellular
0.35	GO:0012505	endomembrane system
0.34	GO:0043227	membrane-bounded organelle
0.34	GO:0032154	cleavage furrow
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1FZ30|T1FZ30_HELRO
Uncharacterized protein
Search

0.63	GO:0006813	potassium ion transport
0.55	GO:0055085	transmembrane transport
0.54	GO:0007165	signal transduction
0.43	GO:0006820	anion transport
0.42	GO:0042493	response to drug
0.40	GO:0071702	organic substance transport
0.40	GO:0007565	female pregnancy
0.40	GO:1905604	negative regulation of maintenance of permeability of blood-brain barrier
0.40	GO:0061855	negative regulation of neuroblast migration
0.40	GO:1900719	regulation of uterine smooth muscle relaxation

0.77	GO:0008281	sulfonylurea receptor activity
0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.50	GO:0044325	ion channel binding
0.49	GO:0005267	potassium channel activity
0.43	GO:0008509	anion transmembrane transporter activity
0.37	GO:0019905	syntaxin binding

0.54	GO:0008282	inward rectifying potassium channel
0.45	GO:0042383	sarcolemma
0.43	GO:0046581	intercellular canaliculus
0.42	GO:0008076	voltage-gated potassium channel complex
0.41	GO:0016324	apical plasma membrane
0.40	GO:0009986	cell surface
0.38	GO:0030672	synaptic vesicle membrane
0.36	GO:0031526	brush border membrane
0.35	GO:0016323	basolateral plasma membrane
0.35	GO:0031088	platelet dense granule membrane

tr|T1FZ31|T1FZ31_HELRO
Uncharacterized protein
Search

0.49	casein kinase I

0.63	GO:0006468	protein phosphorylation
0.49	GO:0016318	ommatidial rotation
0.49	GO:2001135	regulation of endocytic recycling
0.49	GO:0008355	olfactory learning
0.49	GO:0007291	sperm individualization
0.48	GO:0008347	glial cell migration
0.48	GO:0051126	negative regulation of actin nucleation
0.48	GO:0090175	regulation of establishment of planar polarity
0.43	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.43	GO:0009612	response to mechanical stimulus

0.69	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding

0.50	GO:0070864	sperm individualization complex
0.41	GO:0005634	nucleus
0.39	GO:0005886	plasma membrane
0.36	GO:0005829	cytosol
0.35	GO:0005818	aster
0.34	GO:0005938	cell cortex
0.30	GO:0016021	integral component of membrane

0.69

GO:0004674

tr|T1FZ32|T1FZ32_HELRO
Uncharacterized protein
Search

0.63	GO:0006468	protein phosphorylation
0.37	GO:0071688	striated muscle myosin thick filament assembly
0.37	GO:0045214	sarcomere organization
0.37	GO:0006941	striated muscle contraction
0.36	GO:0007015	actin filament organization
0.35	GO:0048769	sarcomerogenesis
0.35	GO:0060298	positive regulation of sarcomere organization
0.35	GO:0035095	behavioral response to nicotine
0.35	GO:0045989	positive regulation of striated muscle contraction
0.35	GO:0060047	heart contraction

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0097493	structural molecule activity conferring elasticity
0.37	GO:0051371	muscle alpha-actinin binding
0.37	GO:0008307	structural constituent of muscle
0.36	GO:0051015	actin filament binding
0.34	GO:0019901	protein kinase binding

0.38	GO:0031672	A band
0.37	GO:0005859	muscle myosin complex
0.37	GO:0030018	Z disc
0.30	GO:0016020	membrane

tr|T1FZ33|T1FZ33_HELRO
Uncharacterized protein
Search

0.73	GO:0048863	stem cell differentiation
0.70	GO:0008284	positive regulation of cell proliferation
0.60	GO:0035556	intracellular signal transduction
0.51	GO:0006915	apoptotic process
0.45	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.43	GO:0060255	regulation of macromolecule metabolic process
0.40	GO:0033674	positive regulation of kinase activity
0.40	GO:1902533	positive regulation of intracellular signal transduction
0.40	GO:0048856	anatomical structure development
0.38	GO:0051173	positive regulation of nitrogen compound metabolic process

0.78	GO:0030971	receptor tyrosine kinase binding
0.50	GO:0019904	protein domain specific binding
0.36	GO:0001784	phosphotyrosine residue binding
0.33	GO:0003682	chromatin binding
0.32	GO:0016301	kinase activity
0.32	GO:0036094	small molecule binding

0.44	GO:0005622	intracellular
0.38	GO:0005886	plasma membrane
0.36	GO:0098794	postsynapse
0.35	GO:0030054	cell junction
0.34	GO:0043228	non-membrane-bounded organelle
0.33	GO:0044422	organelle part
0.30	GO:0016021	integral component of membrane

tr|T1FZ34|T1FZ34_HELRO
Uncharacterized protein
Search

0.87	Putative phospholipid-transporting ATPase IM

0.80	GO:0045332	phospholipid translocation
0.46	GO:0007030	Golgi organization
0.34	GO:0006833	water transport
0.34	GO:0019221	cytokine-mediated signaling pathway
0.34	GO:0055085	transmembrane transport

0.80	GO:0004012	phospholipid-translocating ATPase activity
0.64	GO:0000287	magnesium ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0022803	passive transmembrane transporter activity
0.34	GO:0004896	cytokine receptor activity
0.33	GO:0005515	protein binding

0.49	GO:0005794	Golgi apparatus
0.42	GO:0005886	plasma membrane
0.35	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.80

GO:0004012

tr|T1FZ35|T1FZ35_HELRO
Uncharacterized protein
Search

0.62	Glucose-dependent insulinotropic receptor

0.36	GO:0070647	protein modification by small protein conjugation or removal
0.34	GO:0042073	intraciliary transport
0.33	GO:0060271	cilium assembly
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0006508	proteolysis
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:0006313	transposition, DNA-mediated
0.33	GO:0015074	DNA integration
0.33	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.32	GO:0006355	regulation of transcription, DNA-templated

0.35	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.34	GO:0031683	G-protein beta/gamma-subunit complex binding
0.34	GO:0004842	ubiquitin-protein transferase activity
0.33	GO:0003924	GTPase activity
0.33	GO:0043565	sequence-specific DNA binding
0.33	GO:0015631	tubulin binding
0.33	GO:0019001	guanyl nucleotide binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0004871	signal transducer activity
0.33	GO:0003700	DNA binding transcription factor activity

0.34	GO:0030992	intraciliary transport particle B
0.33	GO:0031514	motile cilium
0.33	GO:0043231	intracellular membrane-bounded organelle
0.32	GO:0044444	cytoplasmic part
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.33	EC:3.6.1.31	GO:0004636
0.34	KEGG:R03876	GO:0004842

tr|T1FZ36|T1FZ36_HELRO
Uncharacterized protein
Search

tr|T1FZ37|T1FZ37_HELRO
Uncharacterized protein
Search

SNRNP25

0.94	Small nuclear ribonucleoprotein 25

0.40	GO:0008380	RNA splicing
0.40	GO:0006397	mRNA processing

0.35

GO:0005515

protein binding

0.66	GO:0005689	U12-type spliceosomal complex
0.65	GO:0045171	intercellular bridge
0.62	GO:0019013	viral nucleocapsid
0.55	GO:0005654	nucleoplasm
0.54	GO:0005829	cytosol

tr|T1FZ38|T1FZ38_HELRO
Uncharacterized protein
Search

0.76	GO:0042273	ribosomal large subunit biogenesis
0.44	GO:0035067	negative regulation of histone acetylation
0.41	GO:0000122	negative regulation of transcription by RNA polymerase II

0.43	GO:0070491	repressing transcription factor binding
0.42	GO:0003714	transcription corepressor activity
0.42	GO:0042393	histone binding

0.86	GO:0030691	Noc2p-Noc3p complex
0.86	GO:0030690	Noc1p-Noc2p complex
0.48	GO:0005730	nucleolus
0.46	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZ39|T1FZ39_HELRO
Uncharacterized protein
Search

tr|T1FZ40|T1FZ40_HELRO
Uncharacterized protein
Search

0.60	cAMP-dependent protein kinase catalytic subunit alpha

0.63	GO:0006468	protein phosphorylation
0.41	GO:0008359	regulation of bicoid mRNA localization
0.41	GO:0048682	sprouting of injured axon
0.41	GO:0007615	anesthesia-resistant memory
0.41	GO:0007228	positive regulation of hh target transcription factor activity
0.40	GO:0007448	anterior/posterior pattern specification, imaginal disc
0.40	GO:0008103	oocyte microtubule cytoskeleton polarization
0.40	GO:0045879	negative regulation of smoothened signaling pathway
0.40	GO:0007317	regulation of pole plasm oskar mRNA localization
0.40	GO:0040040	thermosensory behavior

0.70	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.36	GO:0060089	molecular transducer activity
0.34	GO:0034237	protein kinase A regulatory subunit binding
0.34	GO:0004712	protein serine/threonine/tyrosine kinase activity
0.34	GO:0031625	ubiquitin protein ligase binding
0.34	GO:0019901	protein kinase binding

0.39	GO:0030425	dendrite
0.39	GO:0044297	cell body
0.35	GO:0005952	cAMP-dependent protein kinase complex
0.35	GO:0045171	intercellular bridge
0.35	GO:0005886	plasma membrane
0.34	GO:0005829	cytosol
0.34	GO:0097546	ciliary base
0.34	GO:0044309	neuron spine
0.34	GO:0031594	neuromuscular junction
0.34	GO:0036126	sperm flagellum

0.70

GO:0004674

tr|T1FZ41|T1FZ41_HELRO
Uncharacterized protein
Search

ARL6

0.90	ADP-ribosylation factor-like protein 6

0.44	GO:0060271	cilium assembly
0.42	GO:1903445	protein transport from ciliary membrane to plasma membrane
0.42	GO:0061512	protein localization to cilium
0.41	GO:0032402	melanosome transport
0.41	GO:0010842	retina layer formation
0.41	GO:0008589	regulation of smoothened signaling pathway
0.41	GO:0045444	fat cell differentiation
0.41	GO:0007368	determination of left/right symmetry
0.40	GO:0033339	pectoral fin development
0.40	GO:0070121	Kupffer's vesicle development

0.62	GO:0032550	purine ribonucleoside binding
0.62	GO:0019001	guanyl nucleotide binding
0.51	GO:0032555	purine ribonucleotide binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0005543	phospholipid binding
0.35	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding
0.33	GO:0003924	GTPase activity

0.43	GO:0005622	intracellular
0.42	GO:0005929	cilium
0.40	GO:0120038	plasma membrane bounded cell projection part
0.38	GO:0098590	plasma membrane region
0.38	GO:0048475	coated membrane
0.38	GO:0099512	supramolecular fiber
0.37	GO:0098588	bounding membrane of organelle
0.37	GO:0070062	extracellular exosome
0.36	GO:0043228	non-membrane-bounded organelle
0.36	GO:0098796	membrane protein complex

tr|T1FZ42|T1FZ42_HELRO
Uncharacterized protein
Search

UBIAD1

0.45	UbiA prenyltransferase domain-containing protein 1

0.52	GO:0042371	vitamin K biosynthetic process
0.49	GO:0032194	ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate
0.47	GO:0009234	menaquinone biosynthetic process
0.45	GO:0001885	endothelial cell development
0.44	GO:0071498	cellular response to fluid shear stress
0.43	GO:0098869	cellular oxidant detoxification
0.43	GO:0072358	cardiovascular system development
0.37	GO:0035207	negative regulation of hemocyte proliferation
0.37	GO:0045614	negative regulation of plasmatocyte differentiation
0.37	GO:0035203	regulation of lamellocyte differentiation

0.70	GO:0004659	prenyltransferase activity
0.43	GO:0016209	antioxidant activity
0.43	GO:0004517	nitric-oxide synthase activity
0.33	GO:0043565	sequence-specific DNA binding
0.32	GO:0003700	DNA binding transcription factor activity

0.48	GO:0030173	integral component of Golgi membrane
0.42	GO:0005783	endoplasmic reticulum
0.37	GO:0005634	nucleus
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.35	GO:0005739	mitochondrion

0.70

EC:2.5.1

GO:0004659

tr|T1FZ43|T1FZ43_HELRO
Uncharacterized protein
Search

0.53	GO:0055114	oxidation-reduction process
0.37	GO:0010268	brassinosteroid homeostasis
0.37	GO:0016131	brassinosteroid metabolic process
0.33	GO:0007018	microtubule-based movement
0.33	GO:0032259	methylation

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.66	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.33	GO:0033608	formyl-CoA transferase activity
0.33	GO:0003777	microtubule motor activity
0.33	GO:0008017	microtubule binding
0.33	GO:0008168	methyltransferase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0008144	drug binding

0.30

GO:0031224

intrinsic component of membrane

0.68	EC:1.14	GO:0016705
0.33	KEGG:R07290	GO:0033608

tr|T1FZ44|T1FZ44_HELRO
Uncharacterized protein
Search

0.39	Natural killer cell enhancement factor

0.69	GO:0098869	cellular oxidant detoxification
0.69	GO:0045454	cell redox homeostasis
0.53	GO:0055114	oxidation-reduction process
0.41	GO:0072593	reactive oxygen species metabolic process
0.41	GO:0000302	response to reactive oxygen species
0.40	GO:0010035	response to inorganic substance
0.40	GO:0008340	determination of adult lifespan
0.39	GO:0010286	heat acclimation
0.38	GO:0034599	cellular response to oxidative stress
0.38	GO:0042981	regulation of apoptotic process

0.74	GO:0051920	peroxiredoxin activity
0.51	GO:0004601	peroxidase activity
0.34	GO:0000033	alpha-1,3-mannosyltransferase activity
0.33	GO:0004930	G-protein coupled receptor activity
0.33	GO:0043565	sequence-specific DNA binding
0.33	GO:0003700	DNA binding transcription factor activity

0.34	GO:0005737	cytoplasm
0.33	GO:1905369	endopeptidase complex
0.33	GO:0005634	nucleus
0.33	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.74	EC:1.11.1.15	GO:0051920
0.51	KEGG:R03532	GO:0004601

tr|T1FZ45|T1FZ45_HELRO
Uncharacterized protein
Search

CYB5D1

0.88	Cytochrome b5 domain-containing protein 1

0.42

GO:0090090

negative regulation of canonical Wnt signaling pathway

0.52

GO:0046872

metal ion binding

0.48	GO:0031514	motile cilium
0.30	GO:0044425	membrane part

tr|T1FZ46|T1FZ46_HELRO
Uncharacterized protein
Search

0.85	Glutamate receptor, ionotropic, AMPA 1

0.79	GO:0060079	excitatory postsynaptic potential
0.77	GO:0035235	ionotropic glutamate receptor signaling pathway
0.59	GO:0034220	ion transmembrane transport
0.47	GO:0048899	anterior lateral line development
0.46	GO:0048915	posterior lateral line system development
0.45	GO:0014032	neural crest cell development
0.45	GO:0048701	embryonic cranial skeleton morphogenesis
0.42	GO:0007399	nervous system development

0.82	GO:0005234	extracellularly glutamate-gated ion channel activity
0.77	GO:0004970	ionotropic glutamate receptor activity
0.44	GO:0099094	ligand-gated cation channel activity

0.78	GO:0045211	postsynaptic membrane
0.74	GO:0030054	cell junction
0.46	GO:0032281	AMPA glutamate receptor complex
0.37	GO:0043025	neuronal cell body
0.37	GO:0030425	dendrite

tr|T1FZ47|T1FZ47_HELRO
Uncharacterized protein
Search

tr|T1FZ48|T1FZ48_HELRO
Uncharacterized protein
Search

INPP5A

0.56	Inositol polyphosphate-5-phosphatase A

0.81	GO:0046856	phosphatidylinositol dephosphorylation
0.46	GO:0046855	inositol phosphate dephosphorylation
0.44	GO:0048016	inositol phosphate-mediated signaling

0.51	GO:0016787	hydrolase activity
0.49	GO:0042731	PH domain binding

0.35	GO:0070062	extracellular exosome
0.34	GO:0005622	intracellular
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.51

GO:0016787

tr|T1FZ49|T1FZ49_HELRO
Uncharacterized protein
Search

0.64	GO:0015711	organic anion transport
0.54	GO:0055085	transmembrane transport
0.35	GO:0042908	xenobiotic transport
0.34	GO:0042221	response to chemical
0.34	GO:0042144	vacuole fusion, non-autophagic
0.33	GO:0006749	glutathione metabolic process
0.33	GO:0006633	fatty acid biosynthetic process
0.33	GO:0015849	organic acid transport
0.33	GO:0045454	cell redox homeostasis
0.32	GO:0071705	nitrogen compound transport

0.66	GO:0008514	organic anion transmembrane transporter activity
0.65	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0042910	xenobiotic transmembrane transporter activity
0.34	GO:0015238	drug transmembrane transporter activity
0.34	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.34	GO:0004075	biotin carboxylase activity
0.33	GO:0003989	acetyl-CoA carboxylase activity

0.63	GO:0005887	integral component of plasma membrane
0.34	GO:0016323	basolateral plasma membrane
0.34	GO:0000329	fungal-type vacuole membrane

0.34

EC:1.3.1.74

GO:0032440

tr|T1FZ50|T1FZ50_HELRO
Uncharacterized protein
Search

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.41	GO:0001525	angiogenesis
0.41	GO:0007124	pseudohyphal growth
0.41	GO:0001403	invasive growth in response to glucose limitation
0.37	GO:0019221	cytokine-mediated signaling pathway
0.35	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
0.35	GO:0035096	larval midgut cell programmed cell death
0.35	GO:0035075	response to ecdysone
0.35	GO:0008045	motor neuron axon guidance
0.34	GO:0007018	microtubule-based movement

0.75	GO:0004725	protein tyrosine phosphatase activity
0.38	GO:0019198	transmembrane receptor protein phosphatase activity
0.37	GO:0004896	cytokine receptor activity
0.35	GO:0050254	rhodopsin kinase activity
0.34	GO:0003777	microtubule motor activity
0.34	GO:0008017	microtubule binding
0.33	GO:0003743	translation initiation factor activity
0.33	GO:0071949	FAD binding
0.33	GO:0004497	monooxygenase activity
0.32	GO:0032559	adenyl ribonucleotide binding

0.40	GO:0043235	receptor complex
0.33	GO:0005887	integral component of plasma membrane
0.32	GO:0005737	cytoplasm

0.75

GO:0004725

tr|T1FZ51|T1FZ51_HELRO
Uncharacterized protein
Search

0.64	GTP binding protein alpha subunit Go

0.82	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
0.47	GO:0014045	establishment of endothelial blood-brain barrier
0.47	GO:0042595	behavioral response to starvation
0.47	GO:0060857	establishment of glial blood-brain barrier
0.47	GO:0061343	cell adhesion involved in heart morphogenesis
0.47	GO:0001737	establishment of imaginal disc-derived wing hair orientation
0.46	GO:0019991	septate junction assembly
0.46	GO:0007419	ventral cord development
0.46	GO:0032291	axon ensheathment in central nervous system
0.46	GO:0045886	negative regulation of synaptic growth at neuromuscular junction

0.81	GO:0031683	G-protein beta/gamma-subunit complex binding
0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.64	GO:0004871	signal transducer activity
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0001664	G-protein coupled receptor binding
0.37	GO:0043495	protein membrane anchor
0.35	GO:0019901	protein kinase binding

0.45	GO:1905360	GTPase complex
0.45	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.41	GO:0098797	plasma membrane protein complex
0.35	GO:0005938	cell cortex
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZ52|T1FZ52_HELRO
Uncharacterized protein
Search

PHF10

0.94	PHD finger protein 10

0.39	GO:0006338	chromatin remodeling
0.38	GO:0007399	nervous system development
0.36	GO:1903506	regulation of nucleic acid-templated transcription
0.36	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.36	GO:0010468	regulation of gene expression
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:1990403	embryonic brain development
0.34	GO:0016570	histone modification
0.34	GO:0018205	peptidyl-lysine modification
0.33	GO:0006475	internal protein amino acid acetylation

0.53	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding
0.34	GO:0004402	histone acetyltransferase activity
0.33	GO:0003676	nucleic acid binding
0.32	GO:0042800	histone methyltransferase activity (H3-K4 specific)

0.82	GO:0071564	npBAF complex
0.34	GO:0031010	ISWI-type complex
0.32	GO:0044666	MLL3/4 complex
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0004402

tr|T1FZ53|T1FZ53_HELRO
Uncharacterized protein
Search

tr|T1FZ54|T1FZ54_HELRO
Uncharacterized protein
Search

SMARCD1

0.88	brahma-associated protein of 60 kDa

0.46	GO:0048096	chromatin-mediated maintenance of transcription
0.45	GO:0031498	chromatin disassembly
0.45	GO:0032986	protein-DNA complex disassembly
0.43	GO:0034728	nucleosome organization
0.41	GO:0060216	definitive hemopoiesis
0.41	GO:0021510	spinal cord development
0.41	GO:0002244	hematopoietic progenitor cell differentiation
0.41	GO:0061053	somite development
0.36	GO:0071398	cellular response to fatty acid
0.34	GO:0035725	sodium ion transmembrane transport

0.44	GO:0032947	protein complex scaffold activity
0.35	GO:0003682	chromatin binding
0.35	GO:0005102	receptor binding
0.34	GO:0005272	sodium channel activity
0.34	GO:0003713	transcription coactivator activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.84	GO:0071565	nBAF complex
0.84	GO:0071564	npBAF complex
0.82	GO:0016514	SWI/SNF complex
0.41	GO:0005654	nucleoplasm
0.34	GO:0030131	clathrin adaptor complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZ55|T1FZ55_HELRO
Uncharacterized protein
Search

NAMPT

0.41	Nicotinamide phosphoribosyltransferase b

0.73	GO:0009435	NAD biosynthetic process
0.41	GO:0006415	translational termination
0.35	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
0.34	GO:0032922	circadian regulation of gene expression
0.34	GO:0032259	methylation
0.34	GO:0006771	riboflavin metabolic process
0.33	GO:0042727	flavin-containing compound biosynthetic process
0.33	GO:0045944	positive regulation of transcription by RNA polymerase II
0.33	GO:0042364	water-soluble vitamin biosynthetic process
0.32	GO:0016310	phosphorylation

0.77	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity
0.43	GO:0047280	nicotinamide phosphoribosyltransferase activity
0.42	GO:0003747	translation release factor activity
0.36	GO:0004516	nicotinate phosphoribosyltransferase activity
0.34	GO:0008531	riboflavin kinase activity
0.34	GO:0008168	methyltransferase activity
0.33	GO:0042802	identical protein binding

0.34	GO:0016607	nuclear speck
0.33	GO:0030054	cell junction
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.77	EC:2.4.2.19	GO:0004514
0.77	KEGG:R03348	GO:0004514

tr|T1FZ56|T1FZ56_HELRO
Synaptotagmin 46
Search

0.58	Synaptotagmin XII

0.81	GO:0060291	long-term synaptic potentiation
0.81	GO:0046928	regulation of neurotransmitter secretion
0.54	GO:0006887	exocytosis
0.49	GO:0017158	regulation of calcium ion-dependent exocytosis
0.48	GO:0048489	synaptic vesicle transport
0.48	GO:0099504	synaptic vesicle cycle
0.48	GO:0099643	signal release from synapse
0.48	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.48	GO:0006906	vesicle fusion
0.46	GO:0006836	neurotransmitter transport

0.56	GO:0005544	calcium-dependent phospholipid binding
0.48	GO:0019905	syntaxin binding
0.47	GO:0030276	clathrin binding
0.43	GO:0005509	calcium ion binding
0.33	GO:0043565	sequence-specific DNA binding

0.47	GO:0098793	presynapse
0.39	GO:0005886	plasma membrane
0.37	GO:0099501	exocytic vesicle membrane
0.36	GO:0030054	cell junction
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

tr|T1FZ57|T1FZ57_HELRO
Uncharacterized protein
Search

PIH1D1

0.67	PIH1 domain-containing protein 1

0.86	GO:0000492	box C/D snoRNP assembly
0.65	GO:0006364	rRNA processing
0.53	GO:1900110	negative regulation of histone H3-K9 dimethylation
0.53	GO:1902661	positive regulation of glucose mediated signaling pathway
0.52	GO:2000619	negative regulation of histone H4-K16 acetylation
0.52	GO:1900113	negative regulation of histone H3-K9 trimethylation
0.52	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
0.52	GO:0090240	positive regulation of histone H4 acetylation
0.52	GO:0048254	snoRNA localization
0.52	GO:0071169	establishment of protein localization to chromatin

0.50	GO:0001164	RNA polymerase I CORE element sequence-specific DNA binding
0.50	GO:0051117	ATPase binding
0.49	GO:0051219	phosphoprotein binding
0.48	GO:0042393	histone binding
0.47	GO:0019901	protein kinase binding

0.82	GO:0097255	R2TP complex
0.60	GO:0030529	intracellular ribonucleoprotein complex
0.47	GO:0005737	cytoplasm
0.45	GO:0005730	nucleolus

tr|T1FZ58|T1FZ58_HELRO
Uncharacterized protein
Search

tr|T1FZ59|T1FZ59_HELRO
Uncharacterized protein
Search

tr|T1FZ60|T1FZ60_HELRO
60S ribosomal protein L36
Search

0.64	Ribosomal protein L36

0.59	GO:0043043	peptide biosynthetic process
0.55	GO:0044267	cellular protein metabolic process
0.53	GO:0010467	gene expression
0.52	GO:0009059	macromolecule biosynthetic process
0.34	GO:0006637	acyl-CoA metabolic process

0.63	GO:0003735	structural constituent of ribosome
0.38	GO:0003723	RNA binding
0.34	GO:0047617	acyl-CoA hydrolase activity

0.61	GO:0005840	ribosome
0.41	GO:0044445	cytosolic part
0.37	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.34

EC:3.1.2 EC:3.1.2.20

GO:0047617

tr|T1FZ61|T1FZ61_HELRO
Uncharacterized protein
Search

0.48	GO:0030198	extracellular matrix organization
0.47	GO:0031104	dendrite regeneration
0.45	GO:0048678	response to axon injury
0.45	GO:0008347	glial cell migration
0.44	GO:0001764	neuron migration
0.44	GO:0010952	positive regulation of peptidase activity
0.43	GO:0007411	axon guidance
0.39	GO:0007155	cell adhesion
0.39	GO:0006030	chitin metabolic process
0.37	GO:0048050	post-embryonic eye morphogenesis

0.70	GO:0005509	calcium ion binding
0.50	GO:0005201	extracellular matrix structural constituent
0.45	GO:0016504	peptidase activator activity
0.38	GO:0008061	chitin binding
0.37	GO:0004872	receptor activity
0.36	GO:0004871	signal transducer activity
0.36	GO:0004713	protein tyrosine kinase activity
0.35	GO:0005102	receptor binding
0.35	GO:0032403	protein complex binding
0.35	GO:0008201	heparin binding

0.55	GO:0031012	extracellular matrix
0.42	GO:0005615	extracellular space
0.34	GO:0099512	supramolecular fiber
0.33	GO:0005634	nucleus
0.33	GO:0043234	protein complex
0.32	GO:0043235	receptor complex
0.32	GO:0005886	plasma membrane
0.31	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.36

GO:0004713

tr|T1FZ62|T1FZ62_HELRO
Uncharacterized protein
Search

0.63	GO:0006468	protein phosphorylation
0.46	GO:0007099	centriole replication
0.37	GO:0035556	intracellular signal transduction
0.36	GO:0006744	ubiquinone biosynthetic process
0.35	GO:0046601	positive regulation of centriole replication
0.35	GO:0009753	response to jasmonic acid
0.35	GO:0097742	de novo centriole assembly
0.35	GO:1903251	multi-ciliated epithelial cell differentiation
0.35	GO:0009611	response to wounding
0.34	GO:0006182	cGMP biosynthetic process

0.64	GO:0004672	protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
0.36	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
0.36	GO:0071949	FAD binding
0.35	GO:0046872	metal ion binding
0.34	GO:0004871	signal transducer activity

0.45	GO:0005814	centriole
0.37	GO:0031314	extrinsic component of mitochondrial inner membrane
0.35	GO:0098536	deuterosome
0.34	GO:0016459	myosin complex
0.34	GO:0005813	centrosome
0.34	GO:0055044	symplast
0.34	GO:0005730	nucleolus
0.34	GO:0005911	cell-cell junction
0.34	GO:0000922	spindle pole
0.33	GO:0005886	plasma membrane

0.37

EC:1.14.14

GO:0016712

tr|T1FZ63|T1FZ63_HELRO
Uncharacterized protein
Search

0.47	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.44	GO:0006621	protein retention in ER lumen
0.42	GO:0006888	ER to Golgi vesicle-mediated transport

0.43	GO:0030137	COPI-coated vesicle
0.43	GO:0000324	fungal-type vacuole
0.43	GO:0030134	COPII-coated ER to Golgi transport vesicle
0.41	GO:0005794	Golgi apparatus
0.40	GO:0005783	endoplasmic reticulum
0.30	GO:0044425	membrane part

tr|T1FZ64|T1FZ64_HELRO
Uncharacterized protein
Search

0.60	G-protein coupled receptor 142

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.38	GO:0008344	adult locomotory behavior
0.37	GO:0008345	larval locomotory behavior
0.37	GO:0002209	behavioral defense response
0.34	GO:0016998	cell wall macromolecule catabolic process
0.34	GO:0009253	peptidoglycan catabolic process

0.78	GO:0008528	G-protein coupled peptide receptor activity
0.34	GO:0003796	lysozyme activity

0.36

GO:0005887

integral component of plasma membrane

0.34

EC:3.2.1.17

GO:0003796

tr|T1FZ65|T1FZ65_HELRO
Uncharacterized protein
Search

0.44	GO:0007166	cell surface receptor signaling pathway
0.44	GO:0007186	G-protein coupled receptor signaling pathway
0.44	GO:0061036	positive regulation of cartilage development
0.41	GO:0006508	proteolysis
0.41	GO:0007155	cell adhesion
0.40	GO:0060958	endocardial cell development
0.40	GO:0003250	regulation of cell proliferation involved in heart valve morphogenesis
0.39	GO:0003160	endocardium morphogenesis
0.39	GO:0048570	notochord morphogenesis
0.39	GO:0001570	vasculogenesis

0.70	GO:0005509	calcium ion binding
0.56	GO:0005201	extracellular matrix structural constituent
0.45	GO:0004222	metalloendopeptidase activity
0.44	GO:0004930	G-protein coupled receptor activity
0.41	GO:0008270	zinc ion binding
0.40	GO:0042802	identical protein binding
0.34	GO:0005102	receptor binding
0.34	GO:0030247	polysaccharide binding
0.34	GO:0001540	amyloid-beta binding
0.33	GO:0030545	receptor regulator activity

0.54	GO:0044421	extracellular region part
0.36	GO:0009986	cell surface
0.34	GO:0031982	vesicle
0.34	GO:0012505	endomembrane system
0.34	GO:0031526	brush border membrane
0.33	GO:0016324	apical plasma membrane
0.33	GO:0030425	dendrite
0.33	GO:0030424	axon
0.33	GO:0098589	membrane region
0.33	GO:0098552	side of membrane

0.45

GO:0004222

tr|T1FZ66|T1FZ66_HELRO
Uncharacterized protein
Search

TSPAN31

0.85	Tetraspannin

0.43	GO:0007166	cell surface receptor signaling pathway
0.43	GO:1903169	regulation of calcium ion transmembrane transport
0.39	GO:0065009	regulation of molecular function
0.34	GO:0008284	positive regulation of cell proliferation

0.44	GO:0005246	calcium channel regulator activity
0.32	GO:0005515	protein binding

0.42

GO:0005887

integral component of plasma membrane

tr|T1FZ67|T1FZ67_HELRO
Uncharacterized protein
Search

CAMKK2

0.90	Calcium/calmodulin-dependent protein kinase kinase 2 beta

0.62	GO:0006468	protein phosphorylation
0.54	GO:0061762	CAMKK-AMPK signaling cascade
0.49	GO:0001934	positive regulation of protein phosphorylation
0.43	GO:0018210	peptidyl-threonine modification
0.43	GO:0018209	peptidyl-serine modification
0.42	GO:0033674	positive regulation of kinase activity
0.41	GO:0045859	regulation of protein kinase activity
0.35	GO:1903599	positive regulation of autophagy of mitochondrion
0.34	GO:0018212	peptidyl-tyrosine modification
0.34	GO:0034614	cellular response to reactive oxygen species

0.63	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0005509	calcium ion binding
0.42	GO:0005516	calmodulin binding
0.34	GO:0030295	protein kinase activator activity

0.45	GO:0005829	cytosol
0.38	GO:0005634	nucleus
0.35	GO:0042995	cell projection

tr|T1FZ68|T1FZ68_HELRO
Uncharacterized protein
Search

0.59	Allatostatin-A receptor

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.53	GO:1904325	positive regulation of inhibitory G-protein coupled receptor phosphorylation
0.51	GO:0043951	negative regulation of cAMP-mediated signaling
0.51	GO:0048514	blood vessel morphogenesis
0.51	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
0.51	GO:0007507	heart development
0.51	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
0.48	GO:0030154	cell differentiation
0.45	GO:0007369	gastrulation
0.45	GO:1900107	regulation of nodal signaling pathway

0.71	GO:0004930	G-protein coupled receptor activity
0.60	GO:0001653	peptide receptor activity
0.39	GO:0042923	neuropeptide binding
0.34	GO:0004931	extracellularly ATP-gated cation channel activity
0.34	GO:0001614	purinergic nucleotide receptor activity
0.33	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.33	GO:0001618	virus receptor activity
0.33	GO:0015026	coreceptor activity
0.33	GO:0005515	protein binding
0.33	GO:0030246	carbohydrate binding

0.40	GO:0005886	plasma membrane
0.37	GO:0043005	neuron projection
0.33	GO:0098794	postsynapse
0.33	GO:0070701	mucus layer
0.33	GO:0005768	endosome
0.32	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.33

GO:0004553

tr|T1FZ69|T1FZ69_HELRO
Uncharacterized protein
Search

DNAH10

0.88	Axonemal inner arm dynein heavy chain 7

0.74	GO:0007018	microtubule-based movement
0.34	GO:0099518	vesicle cytoskeletal trafficking
0.34	GO:0031122	cytoplasmic microtubule organization
0.33	GO:0060271	cilium assembly
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.32	GO:0006508	proteolysis
0.31	GO:0015991	ATP hydrolysis coupled proton transport
0.31	GO:0006289	nucleotide-excision repair
0.31	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.31	GO:1903506	regulation of nucleic acid-templated transcription

0.75	GO:0003777	microtubule motor activity
0.59	GO:0016887	ATPase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0045503	dynein light chain binding
0.52	GO:0051959	dynein light intermediate chain binding
0.52	GO:0045505	dynein intermediate chain binding
0.33	GO:0004930	G-protein coupled receptor activity
0.32	GO:0070001	aspartic-type peptidase activity

0.77	GO:0030286	dynein complex
0.41	GO:0005929	cilium
0.38	GO:0032838	plasma membrane bounded cell projection cytoplasm
0.35	GO:0005874	microtubule
0.31	GO:0000439	core TFIIH complex
0.31	GO:0033179	proton-transporting V-type ATPase, V0 domain
0.30	GO:0031224	intrinsic component of membrane

0.59

GO:0016887

tr|T1FZ70|T1FZ70_HELRO
Uncharacterized protein
Search

0.89	Intraflagellar transport protein 81-like protein (Fragment)

0.84	GO:0042073	intraciliary transport
0.80	GO:0060271	cilium assembly
0.56	GO:0007283	spermatogenesis
0.53	GO:0048793	pronephros development
0.50	GO:0032006	regulation of TOR signaling

0.74

GO:0015631

tubulin binding

0.85	GO:0030992	intraciliary transport particle B
0.77	GO:0005929	cilium
0.57	GO:0097223	sperm part
0.56	GO:0005813	centrosome
0.53	GO:0120038	plasma membrane bounded cell projection part

tr|T1FZ71|T1FZ71_HELRO
Uncharacterized protein
Search

tr|T1FZ72|T1FZ72_HELRO
Uncharacterized protein
Search

0.10	Formin homology 2 domain containing 3 (Fragment)

0.65	GO:0007015	actin filament organization
0.53	GO:0110053	regulation of actin filament organization
0.52	GO:0110020	regulation of actomyosin structure organization
0.48	GO:0044087	regulation of cellular component biogenesis
0.46	GO:0009888	tissue development
0.46	GO:0048468	cell development
0.46	GO:0035070	salivary gland histolysis
0.46	GO:0060439	trachea morphogenesis
0.45	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
0.45	GO:0046716	muscle cell cellular homeostasis

0.39

GO:0003779

actin binding

0.43	GO:0030017	sarcomere
0.43	GO:0048471	perinuclear region of cytoplasm
0.38	GO:0005634	nucleus
0.35	GO:0036379	myofilament
0.34	GO:0015629	actin cytoskeleton
0.34	GO:0044430	cytoskeletal part
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZ73|T1FZ73_HELRO
Uncharacterized protein
Search

0.46	Sodium-independent sulfate anion transporter

0.75	GO:1902358	sulfate transmembrane transport
0.40	GO:0015701	bicarbonate transport
0.40	GO:0019532	oxalate transport
0.40	GO:0051453	regulation of intracellular pH
0.39	GO:0042391	regulation of membrane potential
0.38	GO:1902476	chloride transmembrane transport

0.78	GO:0008271	secondary active sulfate transmembrane transporter activity
0.41	GO:0015106	bicarbonate transmembrane transporter activity
0.40	GO:0019531	oxalate transmembrane transporter activity
0.40	GO:0015301	anion:anion antiporter activity
0.39	GO:0005254	chloride channel activity
0.33	GO:0008270	zinc ion binding
0.32	GO:0003676	nucleic acid binding

0.37	GO:0005887	integral component of plasma membrane
0.33	GO:0005634	nucleus

tr|T1FZ74|T1FZ74_HELRO
Uncharacterized protein
Search

GATA3

0.63	Glucocorticoid receptor-like (DNA-binding domain) (Fragment)

0.60	GO:0030221	basophil differentiation
0.60	GO:0030222	eosinophil differentiation
0.58	GO:0030219	megakaryocyte differentiation
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:0048821	erythrocyte development
0.56	GO:0010468	regulation of gene expression
0.52	GO:0010724	regulation of definitive erythrocyte differentiation
0.52	GO:0010725	regulation of primitive erythrocyte differentiation
0.51	GO:0090202	gene looping

0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.51	GO:0070742	C2H2 zinc finger domain binding
0.49	GO:0001085	RNA polymerase II transcription factor binding
0.49	GO:0044212	transcription regulatory region DNA binding
0.49	GO:0008301	DNA binding, bending
0.49	GO:0002039	p53 binding
0.48	GO:0031490	chromatin DNA binding
0.47	GO:0003690	double-stranded DNA binding

0.47	GO:0017053	transcriptional repressor complex
0.47	GO:0005634	nucleus
0.46	GO:0005667	transcription factor complex
0.44	GO:0032993	protein-DNA complex
0.33	GO:0070013	intracellular organelle lumen
0.32	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.34

EC:3.5.1.98

GO:0032041

tr|T1FZ75|T1FZ75_HELRO
Uncharacterized protein
Search

tr|T1FZ76|T1FZ76_HELRO
Uncharacterized protein
Search

B9D2

0.93	Transforming growth factor beta 1

0.76	GO:0060271	cilium assembly
0.63	GO:0036372	opsin transport
0.58	GO:0001736	establishment of planar polarity
0.55	GO:0007163	establishment or maintenance of cell polarity
0.45	GO:1900126	negative regulation of hyaluronan biosynthetic process
0.44	GO:1901664	regulation of NAD+ ADP-ribosyltransferase activity
0.44	GO:0043932	ossification involved in bone remodeling
0.44	GO:0048298	positive regulation of isotype switching to IgA isotypes
0.44	GO:0007182	common-partner SMAD protein phosphorylation
0.44	GO:0010936	negative regulation of macrophage cytokine production

0.71	GO:0043015	gamma-tubulin binding
0.44	GO:0034714	type III transforming growth factor beta receptor binding
0.44	GO:0005114	type II transforming growth factor beta receptor binding
0.44	GO:0034713	type I transforming growth factor beta receptor binding
0.43	GO:0003823	antigen binding
0.42	GO:0008083	growth factor activity
0.36	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.34	GO:0004190	aspartic-type endopeptidase activity
0.33	GO:0046872	metal ion binding

0.75	GO:0036038	MKS complex
0.73	GO:0036064	ciliary basal body
0.68	GO:0005813	centrosome
0.43	GO:0072562	blood microparticle
0.42	GO:0005634	nucleus
0.40	GO:0009986	cell surface
0.38	GO:0005737	cytoplasm
0.38	GO:0044292	dendrite terminus
0.30	GO:0016020	membrane

0.34

EC:3.4.23

GO:0004190

tr|T1FZ77|T1FZ77_HELRO
Uncharacterized protein
Search

RSPH1

0.58	Radial spoke head 1

0.75	GO:0035082	axoneme assembly
0.74	GO:0007286	spermatid development
0.50	GO:0046854	phosphatidylinositol phosphorylation
0.41	GO:0051321	meiotic cell cycle
0.38	GO:0032259	methylation
0.35	GO:0016570	histone modification
0.35	GO:0018205	peptidyl-lysine modification
0.35	GO:0008213	protein alkylation

0.54	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity
0.41	GO:0032559	adenyl ribonucleotide binding
0.41	GO:0008144	drug binding
0.41	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0008168	methyltransferase activity
0.35	GO:0005515	protein binding
0.33	GO:0140096	catalytic activity, acting on a protein

0.79	GO:0001520	outer dense fiber
0.78	GO:0072687	meiotic spindle
0.71	GO:0000794	condensed nuclear chromosome
0.46	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.54	EC:2.7.1.68	GO:0016308
0.54	KEGG:R03469	GO:0016308

tr|T1FZ78|T1FZ78_HELRO
Uncharacterized protein
Search

RFK

0.66	Riboflavin kinase

0.73	GO:0006771	riboflavin metabolic process
0.73	GO:0042727	flavin-containing compound biosynthetic process
0.67	GO:0042364	water-soluble vitamin biosynthetic process
0.57	GO:0016310	phosphorylation
0.51	GO:0033864	positive regulation of NAD(P)H oxidase activity
0.45	GO:0006915	apoptotic process
0.45	GO:0046444	FMN metabolic process
0.43	GO:0072593	reactive oxygen species metabolic process
0.42	GO:0046443	FAD metabolic process
0.41	GO:0009156	ribonucleoside monophosphate biosynthetic process

0.79	GO:0008531	riboflavin kinase activity
0.43	GO:0003919	FMN adenylyltransferase activity
0.37	GO:0032559	adenyl ribonucleotide binding
0.37	GO:0008144	drug binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding
0.34	GO:0046872	metal ion binding

0.40	GO:0005739	mitochondrion
0.34	GO:0019866	organelle inner membrane
0.34	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.79	EC:2.7.1.26	GO:0008531
0.79	KEGG:R00549	GO:0008531

tr|T1FZ79|T1FZ79_HELRO
Uncharacterized protein
Search

0.81	Mitochondrial tricarboxylate/dicarboxylate carrier

0.45	GO:0006843	mitochondrial citrate transport
0.44	GO:0055085	transmembrane transport
0.36	GO:0048268	clathrin coat assembly
0.36	GO:0010821	regulation of mitochondrion organization
0.35	GO:0046326	positive regulation of glucose import
0.34	GO:0006886	intracellular protein transport
0.34	GO:0016192	vesicle-mediated transport
0.34	GO:0016482	cytosolic transport
0.34	GO:0016197	endosomal transport
0.34	GO:0000278	mitotic cell cycle

0.43	GO:0015137	citrate transmembrane transporter activity
0.36	GO:0032051	clathrin light chain binding
0.34	GO:0005198	structural molecule activity

0.39	GO:0031090	organelle membrane
0.38	GO:0044429	mitochondrial part
0.38	GO:0031967	organelle envelope
0.36	GO:0071439	clathrin complex
0.36	GO:0030140	trans-Golgi network transport vesicle
0.36	GO:0030132	clathrin coat of coated pit
0.35	GO:0044433	cytoplasmic vesicle part
0.35	GO:0097443	sorting endosome
0.35	GO:0044431	Golgi apparatus part
0.34	GO:0005770	late endosome

tr|T1FZ80|T1FZ80_HELRO
Uncharacterized protein
Search

0.70	Huntingtin-interacting protein HYPK

0.30

GO:0044425

membrane part

tr|T1FZ81|T1FZ81_HELRO
Uncharacterized protein
Search

INPP5B

0.82	Oculocerebrorenal syndrome of Lowe

0.81	GO:0046856	phosphatidylinositol dephosphorylation
0.60	GO:0007165	signal transduction
0.52	GO:0043009	chordate embryonic development
0.51	GO:0060271	cilium assembly
0.48	GO:0043547	positive regulation of GTPase activity
0.44	GO:0030317	flagellated sperm motility
0.44	GO:0070613	regulation of protein processing
0.43	GO:0007283	spermatogenesis
0.41	GO:0071871	response to epinephrine
0.41	GO:0032402	melanosome transport

0.80	GO:0052745	inositol phosphate phosphatase activity
0.59	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
0.52	GO:0048365	Rac GTPase binding
0.48	GO:0005096	GTPase activator activity
0.35	GO:0043813	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
0.34	GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity

0.51	GO:0001750	photoreceptor outer segment
0.50	GO:0005769	early endosome
0.49	GO:0005802	trans-Golgi network
0.49	GO:0030136	clathrin-coated vesicle
0.42	GO:0005634	nucleus
0.40	GO:0005829	cytosol
0.40	GO:0005886	plasma membrane
0.37	GO:0030670	phagocytic vesicle membrane
0.37	GO:0005905	clathrin-coated pit
0.36	GO:0010008	endosome membrane

0.80	EC:3.1.3	GO:0052745
0.59	KEGG:R04404	GO:0004439

tr|T1FZ82|T1FZ82_HELRO
Protein kinase C
Search

0.52	Protein kinase C delta type

0.63	GO:0006468	protein phosphorylation
0.62	GO:0035556	intracellular signal transduction
0.54	GO:0010744	positive regulation of macrophage derived foam cell differentiation
0.54	GO:0045618	positive regulation of keratinocyte differentiation
0.54	GO:0034351	negative regulation of glial cell apoptotic process
0.54	GO:0060252	positive regulation of glial cell proliferation
0.54	GO:0050861	positive regulation of B cell receptor signaling pathway
0.53	GO:2000810	regulation of bicellular tight junction assembly
0.51	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.47	GO:0018209	peptidyl-serine modification

0.83	GO:0004697	protein kinase C activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0046872	metal ion binding
0.53	GO:0017160	Ral GTPase binding
0.34	GO:0004713	protein tyrosine kinase activity

0.48	GO:0005911	cell-cell junction
0.45	GO:0005829	cytosol
0.40	GO:0005886	plasma membrane
0.37	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0070062	extracellular exosome
0.34	GO:0005634	nucleus

0.83

EC:2.7.11.13

GO:0004697

tr|T1FZ83|T1FZ83_HELRO
Uncharacterized protein
Search

RHOA

0.78	Ras homolog gene family, member Aa

0.79	GO:1902766	skeletal muscle satellite cell migration
0.77	GO:0007264	small GTPase mediated signal transduction
0.76	GO:0090505	epiboly involved in wound healing
0.72	GO:1903673	mitotic cleavage furrow formation
0.71	GO:0097498	endothelial tube lumen extension
0.70	GO:0043149	stress fiber assembly
0.70	GO:0038027	apolipoprotein A-I-mediated signaling pathway
0.69	GO:1990868	response to chemokine
0.68	GO:0043297	apical junction assembly
0.68	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.65	GO:0017022	myosin binding
0.45	GO:0051022	Rho GDP-dissociation inhibitor binding
0.43	GO:0019003	GDP binding
0.41	GO:0019904	protein domain specific binding

0.66	GO:0097610	cell surface furrow
0.65	GO:0043197	dendritic spine
0.64	GO:0032155	cell division site part
0.62	GO:0043296	apical junction complex
0.61	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.59	GO:0032587	ruffle membrane
0.59	GO:0005938	cell cortex
0.59	GO:0005768	endosome
0.58	GO:0030027	lamellipodium
0.56	GO:0005829	cytosol

tr|T1FZ84|T1FZ84_HELRO
Uncharacterized protein
Search

tr|T1FZ85|T1FZ85_HELRO
Uncharacterized protein
Search

0.70	GO:0034968	histone lysine methylation
0.54	GO:0001501	skeletal system development
0.52	GO:0061448	connective tissue development
0.51	GO:0048513	animal organ development
0.51	GO:0043009	chordate embryonic development
0.46	GO:0048298	positive regulation of isotype switching to IgA isotypes
0.45	GO:2001032	regulation of double-strand break repair via nonhomologous end joining
0.42	GO:0072359	circulatory system development
0.42	GO:0070201	regulation of establishment of protein localization
0.42	GO:0000122	negative regulation of transcription by RNA polymerase II

0.68	GO:0018024	histone-lysine N-methyltransferase activity
0.51	GO:0046872	metal ion binding
0.46	GO:0003677	DNA binding
0.42	GO:0003682	chromatin binding
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0008144	drug binding
0.35	GO:0016301	kinase activity

0.56

GO:0005634

nucleus

0.68

GO:0018024

tr|T1FZ86|T1FZ86_HELRO
Uncharacterized protein
Search

0.61	GO:0006508	proteolysis
0.37	GO:0006954	inflammatory response
0.36	GO:0042756	drinking behavior
0.36	GO:0007275	multicellular organism development
0.34	GO:0048864	stem cell development
0.34	GO:0001667	ameboidal-type cell migration
0.33	GO:0009888	tissue development
0.33	GO:0000272	polysaccharide catabolic process
0.32	GO:0055114	oxidation-reduction process

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.33	GO:0030246	carbohydrate binding
0.32	GO:0003677	DNA binding
0.32	GO:0016491	oxidoreductase activity

0.74	GO:0031012	extracellular matrix
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.70

GO:0004222

tr|T1FZ87|T1FZ87_HELRO
Uncharacterized protein
Search

0.11

Sorcin

0.40	GO:0051260	protein homooligomerization
0.36	GO:0006030	chitin metabolic process
0.35	GO:0019538	protein metabolic process
0.35	GO:0046907	intracellular transport
0.35	GO:1902045	negative regulation of Fas signaling pathway
0.35	GO:0070727	cellular macromolecule localization
0.34	GO:0006950	response to stress
0.34	GO:1903077	negative regulation of protein localization to plasma membrane
0.34	GO:0015031	protein transport
0.34	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

0.46	GO:0005509	calcium ion binding
0.44	GO:0005544	calcium-dependent phospholipid binding
0.37	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.36	GO:0008061	chitin binding
0.35	GO:0003723	RNA binding
0.35	GO:0003697	single-stranded DNA binding
0.35	GO:0004859	phospholipase inhibitor activity
0.34	GO:0005123	death receptor binding
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0004672	protein kinase activity

0.35	GO:0031410	cytoplasmic vesicle
0.35	GO:0098805	whole membrane
0.35	GO:0012505	endomembrane system
0.35	GO:0005576	extracellular region
0.35	GO:0098588	bounding membrane of organelle
0.34	GO:0012506	vesicle membrane
0.34	GO:0030117	membrane coat
0.34	GO:0009279	cell outer membrane
0.34	GO:0005764	lysosome
0.34	GO:0044446	intracellular organelle part

0.34

GO:0004252

tr|T1FZ88|T1FZ88_HELRO
Uncharacterized protein
Search

GCLM

0.75	Glutamate--cysteine ligase regulatory subunit

0.78	GO:0006750	glutathione biosynthetic process
0.45	GO:0035227	regulation of glutamate-cysteine ligase activity
0.44	GO:0051351	positive regulation of ligase activity
0.37	GO:0051900	regulation of mitochondrial depolarization
0.36	GO:0008637	apoptotic mitochondrial changes
0.36	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
0.36	GO:1990830	cellular response to leukemia inhibitory factor
0.36	GO:0050880	regulation of blood vessel size
0.35	GO:0006536	glutamate metabolic process
0.35	GO:0006534	cysteine metabolic process

0.86	GO:0035226	glutamate-cysteine ligase catalytic subunit binding
0.51	GO:0016874	ligase activity
0.39	GO:0030234	enzyme regulator activity
0.35	GO:0046982	protein heterodimerization activity
0.34	GO:0009982	pseudouridine synthase activity
0.33	GO:0003723	RNA binding
0.32	GO:0016491	oxidoreductase activity

0.44

GO:0017109

glutamate-cysteine ligase complex

0.51

GO:0016874

tr|T1FZ89|T1FZ89_HELRO
Uncharacterized protein
Search

VAMP1

0.71	Sodium channel epithelial 1 alpha subunit

0.69	GO:0016192	vesicle-mediated transport
0.47	GO:0090174	organelle membrane fusion
0.46	GO:0016050	vesicle organization
0.41	GO:0032940	secretion by cell
0.40	GO:0043623	cellular protein complex assembly
0.36	GO:0001921	positive regulation of receptor recycling
0.36	GO:0034446	substrate adhesion-dependent cell spreading
0.36	GO:0061951	establishment of protein localization to plasma membrane
0.36	GO:0071346	cellular response to interferon-gamma
0.36	GO:1903531	negative regulation of secretion by cell

0.43	GO:0000149	SNARE binding
0.42	GO:0005484	SNAP receptor activity
0.35	GO:0015280	ligand-gated sodium channel activity
0.35	GO:0050699	WW domain binding

0.44	GO:0031201	SNARE complex
0.43	GO:0035579	specific granule membrane
0.43	GO:0070821	tertiary granule membrane
0.43	GO:0009986	cell surface
0.39	GO:0030672	synaptic vesicle membrane
0.38	GO:0032155	cell division site part
0.38	GO:0120025	plasma membrane bounded cell projection
0.37	GO:0030054	cell junction
0.37	GO:0005739	mitochondrion
0.36	GO:0045335	phagocytic vesicle

tr|T1FZ90|T1FZ90_HELRO
Uncharacterized protein
Search

ALPL

0.47	Intestinal-type alkaline phosphatase

0.68	GO:0016311	dephosphorylation
0.50	GO:0001958	endochondral ossification
0.50	GO:0033280	response to vitamin D
0.47	GO:0071407	cellular response to organic cyclic compound
0.46	GO:0003006	developmental process involved in reproduction
0.45	GO:0046677	response to antibiotic
0.39	GO:0071529	cementum mineralization
0.38	GO:0051384	response to glucocorticoid
0.37	GO:0009612	response to mechanical stimulus
0.37	GO:0032496	response to lipopolysaccharide

0.80	GO:0004035	alkaline phosphatase activity
0.40	GO:0016462	pyrophosphatase activity
0.36	GO:0002020	protease binding
0.35	GO:0046872	metal ion binding

0.51	GO:0065010	extracellular membrane-bounded organelle
0.46	GO:0005578	proteinaceous extracellular matrix
0.40	GO:0005886	plasma membrane
0.39	GO:0031225	anchored component of membrane
0.36	GO:0005615	extracellular space
0.34	GO:1903561	extracellular vesicle
0.30	GO:0016021	integral component of membrane

0.80

EC:3.1.3.1

GO:0004035

tr|T1FZ91|T1FZ91_HELRO
Uncharacterized protein
Search

DSCR3

0.91	Down syndrome critical region protein A

0.61	GO:0007165	signal transduction
0.43	GO:0006886	intracellular protein transport

0.43

GO:0008565

protein transporter activity

0.45	GO:0005768	endosome
0.34	GO:0005634	nucleus

tr|T1FZ92|T1FZ92_HELRO
Ubiquitin-like protein ATG12
Search

0.79	Ubiquitin-like protein ATG12

0.83	GO:0000045	autophagosome assembly
0.41	GO:0006501	C-terminal protein lipidation
0.40	GO:0044804	autophagy of nucleus
0.40	GO:0000422	autophagy of mitochondrion
0.34	GO:0015031	protein transport

0.41

GO:0019776

Atg8 ligase activity

0.49	GO:0005737	cytoplasm
0.39	GO:0098805	whole membrane
0.37	GO:1990234	transferase complex
0.36	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZ93|T1FZ93_HELRO
Uncharacterized protein
Search

CHORDC1

0.89	Cysteine and histidine-rich domain-containing protein 1

0.57	GO:2000299	negative regulation of Rho-dependent protein serine/threonine kinase activity
0.55	GO:0010824	regulation of centrosome duplication
0.53	GO:1900034	regulation of cellular response to heat
0.53	GO:0007229	integrin-mediated signaling pathway
0.49	GO:0061077	chaperone-mediated protein folding

0.65	GO:0051879	Hsp90 protein binding
0.52	GO:0008270	zinc ion binding
0.51	GO:0005509	calcium ion binding
0.48	GO:0043531	ADP binding
0.42	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0003924	GTPase activity
0.41	GO:0032550	purine ribonucleoside binding
0.41	GO:0019001	guanyl nucleotide binding
0.40	GO:0008144	drug binding

0.59

GO:0030018

Z disc

tr|T1FZ94|T1FZ94_HELRO
Uncharacterized protein
Search

tr|T1FZ95|T1FZ95_HELRO
Uncharacterized protein
Search

0.68	Putative rna methylase spou family (Fragment)

0.69	GO:0001510	RNA methylation
0.63	GO:0006396	RNA processing
0.39	GO:0016072	rRNA metabolic process
0.39	GO:0042254	ribosome biogenesis
0.38	GO:0006399	tRNA metabolic process
0.34	GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine
0.34	GO:0006836	neurotransmitter transport
0.33	GO:0098869	cellular oxidant detoxification
0.32	GO:0055085	transmembrane transport
0.32	GO:0055114	oxidation-reduction process

0.69	GO:0008173	RNA methyltransferase activity
0.59	GO:0003723	RNA binding
0.40	GO:0008171	O-methyltransferase activity
0.40	GO:0140102	catalytic activity, acting on a rRNA
0.39	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
0.38	GO:0140101	catalytic activity, acting on a tRNA
0.34	GO:0005328	neurotransmitter:sodium symporter activity
0.34	GO:0004601	peroxidase activity

0.30

GO:0016020

membrane

0.69	EC:2.1.1	GO:0008173
0.34	KEGG:R03532	GO:0004601

tr|T1FZ96|T1FZ96_HELRO
Phospholipid-transporting ATPase
Search

0.59	Phospholipid-transporting ATPase

0.80	GO:0045332	phospholipid translocation
0.36	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.36	GO:0032880	regulation of protein localization
0.36	GO:0007030	Golgi organization

0.81	GO:0004012	phospholipid-translocating ATPase activity
0.64	GO:0000287	magnesium ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.38	GO:0071683	sensory dendrite
0.36	GO:0005929	cilium
0.35	GO:0005794	Golgi apparatus
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.81

GO:0004012

tr|T1FZ97|T1FZ97_HELRO
Uncharacterized protein
Search

DENND4B

0.54	DENN domain-containing protein 4B

0.64	GO:0032483	regulation of Rab protein signal transduction
0.58	GO:0065009	regulation of molecular function

0.73

GO:0017112

Rab guanyl-nucleotide exchange factor activity

0.54	GO:0012505	endomembrane system
0.47	GO:0005634	nucleus
0.46	GO:0044444	cytoplasmic part
0.44	GO:0097708	intracellular vesicle
0.44	GO:0098805	whole membrane
0.43	GO:0098588	bounding membrane of organelle
0.41	GO:0098796	membrane protein complex
0.39	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZ98|T1FZ98_HELRO
Uncharacterized protein
Search

tr|T1FZ99|T1FZ99_HELRO
Uncharacterized protein
Search

0.57	Sodium/potassium-transporting ATPase subunit beta

0.73	GO:0006814	sodium ion transport
0.71	GO:0006813	potassium ion transport
0.54	GO:0035158	regulation of tube diameter, open tracheal system
0.53	GO:0060857	establishment of glial blood-brain barrier
0.53	GO:0061343	cell adhesion involved in heart morphogenesis
0.53	GO:0019991	septate junction assembly
0.52	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
0.50	GO:0007605	sensory perception of sound
0.49	GO:0090662	ATP hydrolysis coupled transmembrane transport
0.42	GO:0098655	cation transmembrane transport

0.52	GO:0005391	sodium:potassium-exchanging ATPase activity
0.36	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
0.35	GO:0005509	calcium ion binding

0.85	GO:0005890	sodium:potassium-exchanging ATPase complex
0.52	GO:0005918	septate junction
0.49	GO:0030424	axon

0.52	EC:3.6.3.9	GO:0005391
0.36	KEGG:R05982 KEGG:R06722	GO:0004571

tr|T1FZA0|T1FZA0_HELRO
Kinesin-like protein
Search

0.10	Kinesin family member 11 (Fragment)

0.74	GO:0007018	microtubule-based movement
0.55	GO:0090307	mitotic spindle assembly
0.54	GO:0046602	regulation of mitotic centrosome separation
0.53	GO:0007100	mitotic centrosome separation
0.44	GO:0007059	chromosome segregation
0.41	GO:0001525	angiogenesis
0.39	GO:0022008	neurogenesis
0.36	GO:0051301	cell division
0.35	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.34	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER

0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0019901	protein kinase binding
0.48	GO:0032403	protein complex binding
0.41	GO:0042623	ATPase activity, coupled
0.33	GO:0005509	calcium ion binding
0.33	GO:0003677	DNA binding

0.57	GO:0005874	microtubule
0.50	GO:0000922	spindle pole
0.50	GO:0072686	mitotic spindle
0.47	GO:0005871	kinesin complex
0.45	GO:0005829	cytosol
0.35	GO:0005813	centrosome
0.33	GO:0005634	nucleus
0.33	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZA1|T1FZA1_HELRO
Uncharacterized protein
Search

GLRA1

0.68	Glycine receptor subunit alpha-1

0.61	GO:0007165	signal transduction
0.60	GO:0034220	ion transmembrane transport
0.60	GO:0060078	regulation of postsynaptic membrane potential
0.59	GO:0007268	chemical synaptic transmission
0.58	GO:0006821	chloride transport
0.54	GO:0051970	negative regulation of transmission of nerve impulse
0.53	GO:0071294	cellular response to zinc ion
0.53	GO:2000344	positive regulation of acrosome reaction
0.53	GO:0060013	righting reflex
0.53	GO:0002087	regulation of respiratory gaseous exchange by neurological system process

0.75	GO:0005230	extracellular ligand-gated ion channel activity
0.70	GO:0004888	transmembrane signaling receptor activity
0.68	GO:0016594	glycine binding
0.65	GO:0099095	ligand-gated anion channel activity
0.61	GO:0022835	transmitter-gated channel activity
0.59	GO:0005254	chloride channel activity
0.55	GO:0043210	alkanesulfonate binding
0.43	GO:0008270	zinc ion binding
0.35	GO:0042802	identical protein binding
0.33	GO:0004190	aspartic-type endopeptidase activity

0.60	GO:0045211	postsynaptic membrane
0.54	GO:0005887	integral component of plasma membrane
0.52	GO:0060077	inhibitory synapse
0.50	GO:0009897	external side of plasma membrane
0.49	GO:0043025	neuronal cell body
0.48	GO:0043005	neuron projection
0.40	GO:0043231	intracellular membrane-bounded organelle
0.37	GO:0034707	chloride channel complex
0.36	GO:0120038	plasma membrane bounded cell projection part
0.36	GO:0030054	cell junction

0.33

EC:3.4.23

GO:0004190

tr|T1FZA2|T1FZA2_HELRO
Uncharacterized protein
Search

0.57

Septin

0.38	GO:0051301	cell division
0.38	GO:0030382	sperm mitochondrion organization
0.38	GO:0017157	regulation of exocytosis
0.37	GO:0048240	sperm capacitation
0.37	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
0.37	GO:0007049	cell cycle
0.37	GO:0031398	positive regulation of protein ubiquitination
0.36	GO:0007420	brain development
0.36	GO:0051260	protein homooligomerization
0.36	GO:0016311	dephosphorylation

0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity
0.37	GO:0003924	GTPase activity
0.36	GO:0042803	protein homodimerization activity
0.35	GO:0000287	magnesium ion binding
0.34	GO:0061711	N(6)-L-threonylcarbamoyladenine synthase
0.33	GO:0004222	metalloendopeptidase activity

0.39	GO:0032156	septin cytoskeleton
0.38	GO:0044448	cell cortex part
0.38	GO:0097227	sperm annulus
0.38	GO:0008021	synaptic vesicle
0.37	GO:0044430	cytoskeletal part
0.37	GO:0043209	myelin sheath
0.35	GO:0005739	mitochondrion
0.34	GO:0005654	nucleoplasm
0.34	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.37

EC:3.1.3.11

GO:0042132

tr|T1FZA3|T1FZA3_HELRO
Uncharacterized protein
Search

0.48	Water-specific aquaporin

0.55	GO:0055085	transmembrane transport
0.45	GO:0006833	water transport
0.40	GO:0050891	multicellular organismal water homeostasis
0.39	GO:0072230	metanephric proximal straight tubule development
0.39	GO:0072232	metanephric proximal convoluted tubule segment 2 development
0.39	GO:0072220	metanephric descending thin limb development
0.39	GO:0085018	maintenance of symbiont-containing vacuole by host
0.39	GO:0003014	renal system process
0.39	GO:0051458	corticotropin secretion
0.39	GO:0007586	digestion

0.69	GO:0022803	passive transmembrane transporter activity
0.45	GO:0005372	water transmembrane transporter activity
0.38	GO:0046875	ephrin receptor binding
0.37	GO:0035379	carbon dioxide transmembrane transporter activity
0.37	GO:0015168	glycerol transmembrane transporter activity
0.36	GO:0015079	potassium ion transmembrane transporter activity
0.36	GO:0030184	nitric oxide transmembrane transporter activity
0.35	GO:0008519	ammonium transmembrane transporter activity
0.34	GO:0042802	identical protein binding
0.34	GO:0046983	protein dimerization activity

0.41	GO:0016324	apical plasma membrane
0.40	GO:0009925	basal plasma membrane
0.38	GO:0020003	symbiont-containing vacuole
0.38	GO:0098805	whole membrane
0.38	GO:0070062	extracellular exosome
0.38	GO:0042807	central vacuole
0.38	GO:0005887	integral component of plasma membrane
0.37	GO:0005903	brush border
0.37	GO:0120025	plasma membrane bounded cell projection
0.37	GO:0044437	vacuolar part

tr|T1FZA4|T1FZA4_HELRO
Uncharacterized protein
Search

0.84	Thyrotropin-releasing hormone receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.40	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.34	GO:0018108	peptidyl-tyrosine phosphorylation
0.33	GO:0001505	regulation of neurotransmitter levels
0.33	GO:0043043	peptide biosynthetic process
0.32	GO:0010467	gene expression
0.32	GO:0009059	macromolecule biosynthetic process
0.32	GO:0007268	chemical synaptic transmission

0.85	GO:0004997	thyrotropin-releasing hormone receptor activity
0.41	GO:0004984	olfactory receptor activity
0.40	GO:0008188	neuropeptide receptor activity
0.34	GO:0004969	histamine receptor activity
0.34	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.33	GO:0003735	structural constituent of ribosome
0.33	GO:0005515	protein binding
0.32	GO:0042923	neuropeptide binding
0.32	GO:0005509	calcium ion binding
0.32	GO:0005549	odorant binding

0.36	GO:0005886	plasma membrane
0.34	GO:0043025	neuronal cell body
0.33	GO:0005840	ribosome
0.32	GO:0043005	neuron projection
0.30	GO:0016021	integral component of membrane

0.34

GO:0004715

tr|T1FZA5|T1FZA5_HELRO
Uncharacterized protein
Search

0.36	GO:0036297	interstrand cross-link repair
0.35	GO:0016567	protein ubiquitination
0.35	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.33	GO:0055114	oxidation-reduction process

0.37	GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds
0.36	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
0.36	GO:0008408	3'-5' exonuclease activity
0.35	GO:0004842	ubiquitin-protein transferase activity
0.34	GO:0016874	ligase activity
0.33	GO:0046872	metal ion binding
0.33	GO:0003676	nucleic acid binding

0.35	GO:0005783	endoplasmic reticulum
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.37	EC:5.3.4	GO:0016864
0.35	KEGG:R03876	GO:0004842

tr|T1FZA6|T1FZA6_HELRO
Uncharacterized protein
Search

0.78	Guanine nucleotide binding protein, alpha stimulating activity polypeptide

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.46	GO:0010353	response to trehalose
0.46	GO:2000253	positive regulation of feeding behavior
0.45	GO:0050916	sensory perception of sweet taste
0.45	GO:0007528	neuromuscular junction development
0.45	GO:0009886	post-embryonic animal morphogenesis
0.44	GO:0035114	imaginal disc-derived appendage morphogenesis
0.44	GO:0035220	wing disc development
0.44	GO:0007552	metamorphosis
0.44	GO:0002165	instar larval or pupal development

0.81	GO:0031683	G-protein beta/gamma-subunit complex binding
0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.64	GO:0004871	signal transducer activity
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0001664	G-protein coupled receptor binding
0.38	GO:0035255	ionotropic glutamate receptor binding
0.38	GO:0051428	peptide hormone receptor binding

0.47	GO:1905360	GTPase complex
0.47	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.43	GO:0005604	basement membrane
0.42	GO:0098797	plasma membrane protein complex
0.34	GO:0005829	cytosol
0.34	GO:0030425	dendrite
0.30	GO:0016021	integral component of membrane

tr|T1FZA7|T1FZA7_HELRO
Uncharacterized protein
Search

0.41	Dual specificity tyrosine-phosphorylation-regulated kinase

0.72	GO:0046777	protein autophosphorylation
0.50	GO:0018108	peptidyl-tyrosine phosphorylation
0.39	GO:0033120	positive regulation of RNA splicing
0.37	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
0.37	GO:0048025	negative regulation of mRNA splicing, via spliceosome
0.37	GO:0090312	positive regulation of protein deacetylation
0.37	GO:0001706	endoderm formation
0.37	GO:0018107	peptidyl-threonine phosphorylation
0.36	GO:0007623	circadian rhythm
0.36	GO:0018105	peptidyl-serine phosphorylation

0.73	GO:0004712	protein serine/threonine/tyrosine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0004674	protein serine/threonine kinase activity
0.50	GO:0004713	protein tyrosine kinase activity
0.38	GO:0048156	tau protein binding
0.37	GO:0043621	protein self-association
0.35	GO:0042802	identical protein binding
0.33	GO:0004252	serine-type endopeptidase activity

0.36	GO:0030425	dendrite
0.36	GO:0030424	axon
0.36	GO:0005856	cytoskeleton
0.36	GO:0005634	nucleus
0.34	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.73

EC:2.7.12.1

GO:0004712

tr|T1FZA8|T1FZA8_HELRO
Uncharacterized protein
Search

0.63	Kunitz-type serine protease inhibitor microlepidin-3

0.76	GO:0010951	negative regulation of endopeptidase activity
0.50	GO:0007596	blood coagulation
0.44	GO:0006508	proteolysis
0.40	GO:0006030	chitin metabolic process
0.37	GO:1900116	extracellular negative regulation of signal transduction
0.36	GO:0043392	negative regulation of DNA binding
0.36	GO:0048869	cellular developmental process
0.36	GO:0060021	palate development
0.36	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.36	GO:0032091	negative regulation of protein binding

0.79	GO:0004867	serine-type endopeptidase inhibitor activity
0.45	GO:0008233	peptidase activity
0.40	GO:0008061	chitin binding
0.37	GO:0050431	transforming growth factor beta binding
0.37	GO:0048019	receptor antagonist activity
0.35	GO:0005516	calmodulin binding
0.35	GO:0008191	metalloendopeptidase inhibitor activity
0.34	GO:0005201	extracellular matrix structural constituent
0.34	GO:0090729	toxin activity
0.33	GO:0017171	serine hydrolase activity

0.54	GO:0005576	extracellular region
0.37	GO:0005581	collagen trimer
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.45

GO:0008233

tr|T1FZA9|T1FZA9_HELRO
Uncharacterized protein
Search

0.81	Suppressor of lurcher protein 1 (Fragment)

0.49	GO:0006508	proteolysis
0.41	GO:0043632	modification-dependent macromolecule catabolic process
0.41	GO:0044257	cellular protein catabolic process
0.40	GO:0006481	C-terminal protein methylation
0.37	GO:0016310	phosphorylation
0.37	GO:0055114	oxidation-reduction process

0.52	GO:0004222	metalloendopeptidase activity
0.50	GO:0005201	extracellular matrix structural constituent
0.50	GO:0005509	calcium ion binding
0.48	GO:0008270	zinc ion binding
0.44	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity
0.41	GO:0051287	NAD binding
0.40	GO:0004671	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
0.38	GO:0016301	kinase activity

0.38	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

0.52	EC:3.4.24	GO:0004222
0.44	KEGG:R00214	GO:0004471

tr|T1FZB0|T1FZB0_HELRO
Uncharacterized protein
Search

0.65	GO:0006936	muscle contraction
0.61	GO:0071688	striated muscle myosin thick filament assembly
0.58	GO:0045214	sarcomere organization
0.56	GO:0006468	protein phosphorylation
0.53	GO:0007015	actin filament organization
0.48	GO:1903955	positive regulation of protein targeting to mitochondrion
0.46	GO:0035023	regulation of Rho protein signal transduction
0.43	GO:0065009	regulation of molecular function
0.43	GO:0033275	actin-myosin filament sliding
0.41	GO:0007155	cell adhesion

0.61	GO:0097493	structural molecule activity conferring elasticity
0.61	GO:0051371	muscle alpha-actinin binding
0.59	GO:0008307	structural constituent of muscle
0.56	GO:0004672	protein kinase activity
0.54	GO:0051015	actin filament binding
0.49	GO:0032559	adenyl ribonucleotide binding
0.48	GO:0008144	drug binding
0.48	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.41	GO:0005200	structural constituent of cytoskeleton

0.60	GO:0005859	muscle myosin complex
0.59	GO:0031430	M band
0.57	GO:0030018	Z disc
0.41	GO:0032982	myosin filament
0.38	GO:0005865	striated muscle thin filament
0.38	GO:0070062	extracellular exosome
0.38	GO:0005829	cytosol
0.38	GO:0000794	condensed nuclear chromosome
0.30	GO:0016020	membrane

tr|T1FZB1|T1FZB1_HELRO
Uncharacterized protein
Search

0.83	OTU domain-containing protein 5-A

0.73	GO:0016579	protein deubiquitination
0.49	GO:0032496	response to lipopolysaccharide
0.38	GO:0072607	interleukin-9 secretion
0.37	GO:1905077	negative regulation of interleukin-17 secretion
0.37	GO:0072619	interleukin-21 secretion
0.37	GO:0072540	T-helper 17 cell lineage commitment
0.37	GO:0006468	protein phosphorylation
0.37	GO:0043374	CD8-positive, alpha-beta T cell differentiation
0.37	GO:2000316	regulation of T-helper 17 type immune response
0.36	GO:0006289	nucleotide-excision repair

0.76	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.49	GO:0061578	Lys63-specific deubiquitinase activity
0.48	GO:1990380	Lys48-specific deubiquitinase activity
0.37	GO:0004672	protein kinase activity
0.36	GO:0003684	damaged DNA binding
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0047750	cholestenol delta-isomerase activity
0.34	GO:0005249	voltage-gated potassium channel activity

0.35	GO:0005634	nucleus
0.34	GO:0008076	voltage-gated potassium channel complex
0.33	GO:0005829	cytosol

0.35

EC:5.3.3.5

GO:0047750

tr|T1FZB2|T1FZB2_HELRO
Uncharacterized protein
Search

tr|T1FZB3|T1FZB3_HELRO
Uncharacterized protein
Search

tr|T1FZB4|T1FZB4_HELRO
Uncharacterized protein
Search

CDK5

0.85	Cyclin-dependent protein kinase 5

0.63	GO:0006468	protein phosphorylation
0.55	GO:0021954	central nervous system neuron development
0.55	GO:0007422	peripheral nervous system development
0.54	GO:1901214	regulation of neuron death
0.54	GO:0031914	negative regulation of synaptic plasticity
0.54	GO:0051402	neuron apoptotic process
0.53	GO:0046826	negative regulation of protein export from nucleus
0.53	GO:0022038	corpus callosum development
0.53	GO:0021819	layer formation in cerebral cortex
0.52	GO:0001963	synaptic transmission, dopaminergic

0.69	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030549	acetylcholine receptor activator activity
0.55	GO:0030554	adenyl nucleotide binding
0.55	GO:0043125	ErbB-3 class receptor binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.53	GO:0005176	ErbB-2 class receptor binding
0.52	GO:0097472	cyclin-dependent protein kinase activity
0.51	GO:0002039	p53 binding

0.51	GO:0030175	filopodium
0.50	GO:0030027	lamellipodium
0.49	GO:0045202	synapse
0.49	GO:0030424	axon
0.47	GO:0030054	cell junction
0.46	GO:0005829	cytosol
0.43	GO:0005634	nucleus
0.41	GO:0030426	growth cone
0.40	GO:0043025	neuronal cell body
0.40	GO:0030425	dendrite

0.69

GO:0004674

tr|T1FZB5|T1FZB5_HELRO
Uncharacterized protein
Search

tr|T1FZB6|T1FZB6_HELRO
Uncharacterized protein
Search

0.40	GO:0032501	multicellular organismal process
0.39	GO:1903506	regulation of nucleic acid-templated transcription
0.39	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.39	GO:0010468	regulation of gene expression
0.39	GO:0035725	sodium ion transmembrane transport
0.38	GO:0048856	anatomical structure development
0.38	GO:0006106	fumarate metabolic process
0.38	GO:0120036	plasma membrane bounded cell projection organization
0.37	GO:0000226	microtubule cytoskeleton organization
0.37	GO:0035335	peptidyl-tyrosine dephosphorylation

0.40	GO:0005248	voltage-gated sodium channel activity
0.38	GO:0003700	DNA binding transcription factor activity
0.38	GO:0004333	fumarate hydratase activity
0.37	GO:0004725	protein tyrosine phosphatase activity
0.37	GO:0003924	GTPase activity
0.37	GO:0070569	uridylyltransferase activity
0.37	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.37	GO:0032550	purine ribonucleoside binding
0.37	GO:0019001	guanyl nucleotide binding
0.36	GO:0046872	metal ion binding

0.40	GO:0001518	voltage-gated sodium channel complex
0.38	GO:0045239	tricarboxylic acid cycle enzyme complex
0.37	GO:0015630	microtubule cytoskeleton
0.35	GO:0005634	nucleus

0.38	EC:4.2.1.2	GO:0004333
0.38	KEGG:R01082	GO:0004333

tr|T1FZB7|T1FZB7_HELRO
Uncharacterized protein
Search

0.72	GO:0045892	negative regulation of transcription, DNA-templated
0.36	GO:0031424	keratinization
0.33	GO:0006351	transcription, DNA-templated

0.36	GO:0003723	RNA binding
0.32	GO:0005515	protein binding

0.44	GO:0005794	Golgi apparatus
0.44	GO:0005654	nucleoplasm
0.43	GO:0005829	cytosol
0.34	GO:0005694	chromosome
0.30	GO:0016020	membrane

tr|T1FZB8|T1FZB8_HELRO
Uncharacterized protein
Search

0.85	Suppressor of cytokine signaling (Fragment)

0.77	GO:0040008	regulation of growth
0.70	GO:0016567	protein ubiquitination
0.62	GO:0035556	intracellular signal transduction
0.52	GO:0046426	negative regulation of JAK-STAT cascade
0.48	GO:0050868	negative regulation of T cell activation
0.48	GO:0010498	proteasomal protein catabolic process
0.47	GO:0006469	negative regulation of protein kinase activity
0.46	GO:0019221	cytokine-mediated signaling pathway
0.39	GO:0051128	regulation of cellular component organization
0.36	GO:0001678	cellular glucose homeostasis

0.47	GO:0004860	protein kinase inhibitor activity
0.45	GO:0008269	JAK pathway signal transduction adaptor activity
0.44	GO:0005159	insulin-like growth factor receptor binding

0.52	GO:0001772	immunological synapse
0.45	GO:0005622	intracellular

tr|T1FZB9|T1FZB9_HELRO
Uncharacterized protein
Search

tr|T1FZC0|T1FZC0_HELRO
Uncharacterized protein
Search

0.34	Serine/threonine-protein kinase PAK mbt (Fragment)

0.63	GO:0006468	protein phosphorylation
0.60	GO:0016049	cell growth
0.58	GO:0006915	apoptotic process
0.55	GO:0007010	cytoskeleton organization
0.45	GO:0045315	positive regulation of compound eye photoreceptor development
0.44	GO:0007266	Rho protein signal transduction
0.44	GO:0031098	stress-activated protein kinase signaling cascade
0.44	GO:2000047	regulation of cell-cell adhesion mediated by cadherin
0.43	GO:0042981	regulation of apoptotic process
0.43	GO:0045792	negative regulation of cell size

0.66	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0017048	Rho GTPase binding
0.34	GO:0005057	signal transducer activity, downstream of receptor
0.33	GO:0003700	DNA binding transcription factor activity
0.32	GO:0003676	nucleic acid binding

0.42	GO:0005913	cell-cell adherens junction
0.39	GO:0005654	nucleoplasm
0.37	GO:0005739	mitochondrion
0.36	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.66

GO:0004674

tr|T1FZC1|T1FZC1_HELRO
Uncharacterized protein
Search

tr|T1FZC2|T1FZC2_HELRO
Annexin
Search

0.61

Annexin

0.41	GO:0009992	cellular water homeostasis
0.41	GO:0006874	cellular calcium ion homeostasis
0.40	GO:0035176	social behavior
0.40	GO:0009651	response to salt stress
0.39	GO:0007599	hemostasis
0.39	GO:0008283	cell proliferation
0.39	GO:0030855	epithelial cell differentiation
0.39	GO:0006914	autophagy
0.38	GO:0048519	negative regulation of biological process
0.37	GO:0051239	regulation of multicellular organismal process

0.81	GO:0005544	calcium-dependent phospholipid binding
0.70	GO:0005509	calcium ion binding
0.43	GO:0048306	calcium-dependent protein binding
0.40	GO:0005178	integrin binding
0.38	GO:0004859	phospholipase inhibitor activity
0.37	GO:0015485	cholesterol binding
0.36	GO:0015276	ligand-gated ion channel activity
0.36	GO:0042803	protein homodimerization activity
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0019001	guanyl nucleotide binding

0.41	GO:0042584	chromaffin granule membrane
0.39	GO:0005635	nuclear envelope
0.38	GO:0005789	endoplasmic reticulum membrane
0.38	GO:0005829	cytosol
0.37	GO:0005764	lysosome
0.37	GO:0031902	late endosome membrane
0.37	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0098852	lytic vacuole membrane
0.35	GO:0005886	plasma membrane
0.34	GO:0042581	specific granule

tr|T1FZC3|T1FZC3_HELRO
Uncharacterized protein
Search

MVB12B

0.95	Multivesicular body subunit 12B

0.62	GO:0019075	virus maturation
0.60	GO:0042058	regulation of epidermal growth factor receptor signaling pathway
0.57	GO:0048524	positive regulation of viral process
0.36	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
0.36	GO:0015031	protein transport
0.36	GO:0016197	endosomal transport
0.35	GO:0075733	intracellular transport of virus

0.53	GO:0008289	lipid binding
0.38	GO:0043130	ubiquitin binding

0.83	GO:0000813	ESCRT I complex
0.57	GO:0005770	late endosome
0.57	GO:0005769	early endosome
0.51	GO:0005829	cytosol
0.47	GO:0005634	nucleus
0.44	GO:0005886	plasma membrane
0.38	GO:0070062	extracellular exosome
0.34	GO:0044215	other organism

tr|T1FZC4|T1FZC4_HELRO
Uncharacterized protein
Search

tr|T1FZC5|T1FZC5_HELRO
Uncharacterized protein
Search

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.50	GO:0038128	ERBB2 signaling pathway
0.48	GO:0010633	negative regulation of epithelial cell migration
0.48	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.47	GO:0001701	in utero embryonic development
0.35	GO:1903385	regulation of homophilic cell adhesion
0.34	GO:0030182	neuron differentiation

0.75	GO:0004725	protein tyrosine phosphatase activity
0.46	GO:0019901	protein kinase binding
0.38	GO:0001784	phosphotyrosine residue binding

0.44	GO:0030054	cell junction
0.42	GO:0005829	cytosol
0.38	GO:0005886	plasma membrane
0.33	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane

0.75

GO:0004725

tr|T1FZC6|T1FZC6_HELRO
Uncharacterized protein
Search

tr|T1FZC7|T1FZC7_HELRO
Uncharacterized protein
Search

CLIP1

0.44	CAP-Gly domain-containing linker protein 1

0.86	GO:0044861	protein transport into plasma membrane raft
0.85	GO:0031116	positive regulation of microtubule polymerization
0.79	GO:0001578	microtubule bundle formation
0.41	GO:1900006	positive regulation of dendrite development
0.39	GO:0007062	sister chromatid cohesion
0.39	GO:0000278	mitotic cell cycle

0.81	GO:0051010	microtubule plus-end binding
0.60	GO:0008270	zinc ion binding
0.44	GO:0042802	identical protein binding
0.40	GO:0046983	protein dimerization activity

0.85	GO:0044354	macropinosome
0.82	GO:0035371	microtubule plus-end
0.79	GO:0005881	cytoplasmic microtubule
0.74	GO:0005813	centrosome
0.72	GO:0005635	nuclear envelope
0.47	GO:0001726	ruffle
0.45	GO:0030659	cytoplasmic vesicle membrane
0.39	GO:0005882	intermediate filament
0.39	GO:0000776	kinetochore
0.37	GO:0005829	cytosol

tr|T1FZC8|T1FZC8_HELRO
Uncharacterized protein
Search

DYNLL2

0.71	Dynein light chain 1 cytoplasmic

0.72	GO:0007017	microtubule-based process
0.50	GO:2000582	positive regulation of ATP-dependent microtubule motor activity, plus-end-directed
0.48	GO:0030705	cytoskeleton-dependent intracellular transport
0.48	GO:0060271	cilium assembly
0.44	GO:0006928	movement of cell or subcellular component
0.41	GO:1902857	positive regulation of non-motile cilium assembly
0.40	GO:0031503	protein complex localization
0.39	GO:0042326	negative regulation of phosphorylation
0.38	GO:0006886	intracellular protein transport
0.37	GO:1904951	positive regulation of establishment of protein localization

0.50	GO:0045505	dynein intermediate chain binding
0.49	GO:0051959	dynein light intermediate chain binding
0.49	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed
0.44	GO:0008092	cytoskeletal protein binding
0.39	GO:0008022	protein C-terminus binding
0.39	GO:0097110	scaffold protein binding
0.38	GO:0019904	protein domain specific binding
0.38	GO:0030235	nitric-oxide synthase regulator activity
0.37	GO:0042803	protein homodimerization activity
0.37	GO:0046982	protein heterodimerization activity

0.79	GO:0030286	dynein complex
0.46	GO:0031475	myosin V complex
0.46	GO:0005813	centrosome
0.42	GO:0005929	cilium
0.40	GO:0072686	mitotic spindle
0.40	GO:0000776	kinetochore
0.40	GO:0008180	COP9 signalosome
0.39	GO:0005874	microtubule
0.38	GO:0120038	plasma membrane bounded cell projection part
0.37	GO:0005829	cytosol

0.49

EC:3.6.4.4

GO:0008574

tr|T1FZC9|T1FZC9_HELRO
Uncharacterized protein
Search

FDFT1

0.71	Farnesyl-diphosphate farnesyltransferase 1

0.80	GO:0006696	ergosterol biosynthetic process
0.48	GO:0045338	farnesyl diphosphate metabolic process
0.48	GO:0006695	cholesterol biosynthetic process
0.38	GO:0008299	isoprenoid biosynthetic process
0.35	GO:0045540	regulation of cholesterol biosynthetic process
0.34	GO:0055114	oxidation-reduction process
0.33	GO:0006289	nucleotide-excision repair

0.81	GO:0004310	farnesyl-diphosphate farnesyltransferase activity
0.81	GO:0051996	squalene synthase activity
0.35	GO:0004452	isopentenyl-diphosphate delta-isomerase activity
0.34	GO:0016491	oxidoreductase activity
0.34	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
0.33	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds
0.33	GO:0003684	damaged DNA binding
0.33	GO:0005515	protein binding
0.33	GO:0008270	zinc ion binding

0.49	GO:0005783	endoplasmic reticulum
0.44	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.43	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.81	EC:2.5.1.21	GO:0004310
0.35	KEGG:R01123	GO:0004452

tr|T1FZD0|T1FZD0_HELRO
Uncharacterized protein
Search

GRIP1

0.53	Glutamate receptor-interacting protein 2

0.81	GO:0016358	dendrite development
0.41	GO:0014824	artery smooth muscle contraction
0.41	GO:0045777	positive regulation of blood pressure
0.41	GO:0008104	protein localization
0.40	GO:0007219	Notch signaling pathway
0.35	GO:0042886	amide transport
0.34	GO:0071702	organic substance transport

0.85	GO:0030159	receptor signaling complex scaffold activity
0.46	GO:0035259	glucocorticoid receptor binding
0.45	GO:0008022	protein C-terminus binding
0.38	GO:0035254	glutamate receptor binding

0.45	GO:0030425	dendrite
0.44	GO:0045121	membrane raft
0.44	GO:0055037	recycling endosome
0.38	GO:0005886	plasma membrane
0.37	GO:0014069	postsynaptic density
0.36	GO:0044309	neuron spine
0.35	GO:0030054	cell junction
0.34	GO:0005783	endoplasmic reticulum
0.34	GO:0005856	cytoskeleton

tr|T1FZD1|T1FZD1_HELRO
Uncharacterized protein
Search

0.56	AP complex subunit sigma

0.69	GO:0006886	intracellular protein transport
0.68	GO:0016192	vesicle-mediated transport
0.40	GO:0042051	compound eye photoreceptor development
0.39	GO:0007411	axon guidance
0.34	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.34	GO:0045176	apical protein localization
0.34	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.33	GO:0050690	regulation of defense response to virus by virus

0.70	GO:0008565	protein transporter activity
0.35	GO:0030276	clathrin binding
0.33	GO:0005509	calcium ion binding

0.75	GO:0030117	membrane coat
0.39	GO:0012510	trans-Golgi network transport vesicle membrane
0.38	GO:0043231	intracellular membrane-bounded organelle
0.34	GO:0005905	clathrin-coated pit
0.33	GO:0005829	cytosol
0.33	GO:0031984	organelle subcompartment
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1FZD2|T1FZD2_HELRO
Uncharacterized protein
Search

tr|T1FZD3|T1FZD3_HELRO
Uncharacterized protein
Search

0.62	Sodium-dependent multivitamin transporter

0.55	GO:0055085	transmembrane transport
0.35	GO:0006814	sodium ion transport
0.35	GO:0051182	coenzyme transport
0.35	GO:0072337	modified amino acid transport
0.34	GO:0051180	vitamin transport
0.34	GO:0015718	monocarboxylic acid transport
0.34	GO:0008643	carbohydrate transport
0.33	GO:0042886	amide transport
0.32	GO:0015992	proton transport

0.57	GO:0022857	transmembrane transporter activity
0.35	GO:0031402	sodium ion binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.34	GO:0005887	integral component of plasma membrane
0.33	GO:0005634	nucleus

tr|T1FZD4|T1FZD4_HELRO
Protein arginine N-methyltransferase
Search

PRMT5

0.71	Protein arginine N-methyltransferase

0.84	GO:0035246	peptidyl-arginine N-methylation
0.76	GO:0034969	histone arginine methylation
0.53	GO:1904990	regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
0.53	GO:0090161	Golgi ribbon formation
0.52	GO:0042118	endothelial cell activation
0.52	GO:0060161	positive regulation of dopamine receptor signaling pathway
0.49	GO:0000387	spliceosomal snRNP assembly
0.46	GO:0006353	DNA-templated transcription, termination
0.45	GO:0048742	regulation of skeletal muscle fiber development
0.40	GO:0032922	circadian regulation of gene expression

0.76	GO:0008469	histone-arginine N-methyltransferase activity
0.53	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity
0.52	GO:0008327	methyl-CpG binding
0.46	GO:0046982	protein heterodimerization activity
0.45	GO:0042802	identical protein binding
0.45	GO:0043021	ribonucleoprotein complex binding
0.40	GO:0001046	core promoter sequence-specific DNA binding
0.39	GO:0003714	transcription corepressor activity
0.35	GO:0032403	protein complex binding
0.34	GO:0003682	chromatin binding

0.60	GO:0005829	cytosol
0.55	GO:0005634	nucleus
0.52	GO:0034709	methylosome
0.46	GO:0005794	Golgi apparatus
0.43	GO:0070013	intracellular organelle lumen
0.40	GO:0044446	intracellular organelle part
0.38	GO:1990463	lateral cortical node
0.38	GO:0071521	Cdc42 GTPase complex
0.37	GO:0051286	cell tip
0.34	GO:0005960	glycine cleavage complex

tr|T1FZD5|T1FZD5_HELRO
Uncharacterized protein
Search

tr|T1FZD6|T1FZD6_HELRO
Uncharacterized protein
Search

DUT

0.42	deoxyuridine 5'-triphosphate nucleotidohydrolase

0.78	GO:0046080	dUTP metabolic process
0.48	GO:0009213	pyrimidine deoxyribonucleoside triphosphate catabolic process
0.48	GO:0009223	pyrimidine deoxyribonucleotide catabolic process
0.45	GO:0006226	dUMP biosynthetic process
0.36	GO:0043497	regulation of protein heterodimerization activity
0.36	GO:0070207	protein homotrimerization
0.36	GO:2000272	negative regulation of receptor activity
0.36	GO:0001889	liver development
0.35	GO:0014070	response to organic cyclic compound
0.35	GO:0015949	nucleobase-containing small molecule interconversion

0.80	GO:0004170	dUTP diphosphatase activity
0.40	GO:0000287	magnesium ion binding
0.37	GO:0032556	pyrimidine deoxyribonucleotide binding
0.37	GO:0042975	peroxisome proliferator activated receptor binding
0.36	GO:0030547	receptor inhibitor activity
0.34	GO:0035870	dITP diphosphatase activity
0.34	GO:0015377	cation:chloride symporter activity
0.33	GO:0003723	RNA binding

0.45	GO:0005654	nucleoplasm
0.41	GO:0005739	mitochondrion
0.35	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.80	EC:3.6.1.23	GO:0004170
0.80	KEGG:R02100	GO:0004170

tr|T1FZD7|T1FZD7_HELRO
Uncharacterized protein
Search

0.22	Receptor-type tyrosine-protein phosphatase H

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.43	GO:0097155	fasciculation of sensory neuron axon
0.42	GO:0007415	defasciculation of motor neuron axon
0.41	GO:0008045	motor neuron axon guidance
0.41	GO:0048813	dendrite morphogenesis
0.38	GO:0045332	phospholipid translocation
0.33	GO:0019221	cytokine-mediated signaling pathway
0.33	GO:0006915	apoptotic process
0.33	GO:0007155	cell adhesion
0.32	GO:0006468	protein phosphorylation

0.75	GO:0004725	protein tyrosine phosphatase activity
0.57	GO:0019198	transmembrane receptor protein phosphatase activity
0.38	GO:0004012	phospholipid-translocating ATPase activity
0.36	GO:0000287	magnesium ion binding
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0050254	rhodopsin kinase activity
0.34	GO:0004896	cytokine receptor activity
0.33	GO:0005515	protein binding

0.43	GO:0120025	plasma membrane bounded cell projection
0.39	GO:0097458	neuron part
0.35	GO:0016324	apical plasma membrane
0.34	GO:0044463	cell projection part
0.33	GO:0005887	integral component of plasma membrane
0.32	GO:0005737	cytoplasm

0.75

GO:0004725

tr|T1FZD8|T1FZD8_HELRO
Uncharacterized protein
Search

LZTFL1

0.95	Leucine zipper transcription factor like 1

0.87	GO:1903565	negative regulation of protein localization to cilium
0.87	GO:1903567	regulation of protein localization to ciliary membrane
0.85	GO:1904376	negative regulation of protein localization to cell periphery
0.85	GO:1905476	negative regulation of protein localization to membrane

0.73	GO:0032403	protein complex binding
0.72	GO:0042802	identical protein binding

0.67

GO:0005829

cytosol

tr|T1FZD9|T1FZD9_HELRO
Uncharacterized protein
Search

0.48	Serine/arginine repetitive matrix protein 2

0.73	GO:0006887	exocytosis
0.46	GO:0000398	mRNA splicing, via spliceosome

0.75	GO:0000145	exocyst
0.48	GO:0071011	precatalytic spliceosome
0.47	GO:0071013	catalytic step 2 spliceosome
0.36	GO:0005684	U2-type spliceosomal complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZE0|T1FZE0_HELRO
Uncharacterized protein
Search

SF3A3

0.82	Splicesome-associated factor 61

0.75	GO:0000398	mRNA splicing, via spliceosome
0.46	GO:0060218	hematopoietic stem cell differentiation
0.36	GO:0046856	phosphatidylinositol dephosphorylation
0.36	GO:0009566	fertilization
0.34	GO:0022618	ribonucleoprotein complex assembly
0.34	GO:0007165	signal transduction

0.63	GO:0008270	zinc ion binding
0.59	GO:0003723	RNA binding
0.35	GO:0052745	inositol phosphate phosphatase activity
0.34	GO:0008970	phosphatidylcholine 1-acylhydrolase activity
0.33	GO:0005515	protein binding

0.76	GO:0005681	spliceosomal complex
0.45	GO:0005654	nucleoplasm
0.42	GO:1902494	catalytic complex
0.33	GO:0005576	extracellular region

0.35

EC:3.1.3

GO:0052745

tr|T1FZE1|T1FZE1_HELRO
Uncharacterized protein
Search

0.59	SH3 and multiple ankyrin repeat domains protein 3

0.85	GO:0048854	brain morphogenesis
0.84	GO:0097117	guanylate kinase-associated protein clustering
0.83	GO:1904717	regulation of AMPA glutamate receptor clustering
0.82	GO:0021773	striatal medium spiny neuron differentiation
0.82	GO:0051835	positive regulation of synapse structural plasticity
0.82	GO:0097114	NMDA glutamate receptor clustering
0.82	GO:0048170	positive regulation of long-term neuronal synaptic plasticity
0.82	GO:0098698	postsynaptic specialization assembly
0.82	GO:0097113	AMPA glutamate receptor clustering
0.81	GO:2000969	positive regulation of AMPA receptor activity

0.79	GO:0035255	ionotropic glutamate receptor binding
0.77	GO:0097110	scaffold protein binding
0.73	GO:0008022	protein C-terminus binding
0.53	GO:0030160	GKAP/Homer scaffold activity
0.49	GO:0043621	protein self-association
0.47	GO:0017124	SH3 domain binding
0.45	GO:0003779	actin binding
0.44	GO:0098919	structural constituent of postsynaptic density
0.42	GO:0008270	zinc ion binding
0.39	GO:0042802	identical protein binding

0.75	GO:0044309	neuron spine
0.51	GO:0005886	plasma membrane
0.49	GO:0014069	postsynaptic density
0.48	GO:0030425	dendrite
0.47	GO:0044441	ciliary part
0.46	GO:0030054	cell junction
0.44	GO:0098588	bounding membrane of organelle
0.42	GO:0005622	intracellular
0.42	GO:0060076	excitatory synapse
0.30	GO:0044425	membrane part

tr|T1FZE2|T1FZE2_HELRO
Uncharacterized protein
Search

0.83	GO:0071526	semaphorin-plexin signaling pathway
0.54	GO:0050772	positive regulation of axonogenesis
0.54	GO:0033689	negative regulation of osteoblast proliferation
0.53	GO:0061430	bone trabecula morphogenesis
0.53	GO:0043931	ossification involved in bone maturation
0.53	GO:0007162	negative regulation of cell adhesion
0.53	GO:0048812	neuron projection morphogenesis
0.52	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
0.49	GO:0048588	developmental cell growth
0.49	GO:0043087	regulation of GTPase activity

0.84	GO:0017154	semaphorin receptor activity
0.53	GO:0032794	GTPase activating protein binding
0.35	GO:0030215	semaphorin receptor binding
0.34	GO:0005096	GTPase activator activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.56	GO:0002116	semaphorin receptor complex
0.45	GO:0005887	integral component of plasma membrane
0.33	GO:0005576	extracellular region
0.32	GO:0005622	intracellular

tr|T1FZE3|T1FZE3_HELRO
Uncharacterized protein
Search

BRIS-1

0.66	IQ motif and SEC7 domain-containing protein 1-like

0.81	GO:0032012	regulation of ARF protein signal transduction
0.66	GO:0065009	regulation of molecular function
0.43	GO:0007520	myoblast fusion
0.41	GO:0030036	actin cytoskeleton organization
0.41	GO:0007417	central nervous system development
0.38	GO:0046579	positive regulation of Ras protein signal transduction
0.33	GO:0016192	vesicle-mediated transport
0.32	GO:0008654	phospholipid biosynthetic process
0.32	GO:0006468	protein phosphorylation

0.82	GO:0005086	ARF guanyl-nucleotide exchange factor activity
0.41	GO:0045296	cadherin binding
0.32	GO:0016780	phosphotransferase activity, for other substituted phosphate groups
0.32	GO:0004672	protein kinase activity
0.31	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.37	GO:0098791	Golgi subcompartment
0.36	GO:0098588	bounding membrane of organelle
0.30	GO:0031224	intrinsic component of membrane

0.32

EC:2.7.8

GO:0016780

tr|T1FZE4|T1FZE4_HELRO
Uncharacterized protein
Search

0.55	GO:0006508	proteolysis
0.43	GO:0043043	peptide biosynthetic process
0.41	GO:0044267	cellular protein metabolic process
0.40	GO:0010467	gene expression
0.40	GO:0009059	macromolecule biosynthetic process

0.56	GO:0008233	peptidase activity
0.50	GO:0030554	adenyl nucleotide binding
0.49	GO:0097367	carbohydrate derivative binding
0.49	GO:0008144	drug binding
0.49	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0003735	structural constituent of ribosome
0.40	GO:0046872	metal ion binding

0.43	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.56

GO:0008233

tr|T1FZE5|T1FZE5_HELRO
Uncharacterized protein
Search

0.50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

0.60	GO:0050662	coenzyme binding
0.33	GO:0016740	transferase activity

0.33

GO:0016740

tr|T1FZE6|T1FZE6_HELRO
Uncharacterized protein
Search

0.82	Cyclin D3 (Predicted)

0.64	GO:0007049	cell cycle
0.52	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
0.52	GO:0042098	T cell proliferation
0.51	GO:0046626	regulation of insulin receptor signaling pathway
0.49	GO:0042127	regulation of cell proliferation
0.49	GO:0000122	negative regulation of transcription by RNA polymerase II
0.42	GO:0051716	cellular response to stimulus
0.42	GO:0023052	signaling
0.42	GO:0007154	cell communication
0.41	GO:0061074	regulation of neural retina development

0.51	GO:0004693	cyclin-dependent protein serine/threonine kinase activity
0.50	GO:0019901	protein kinase binding
0.34	GO:0003714	transcription corepressor activity
0.34	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity

0.60	GO:0005634	nucleus
0.52	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
0.38	GO:0005737	cytoplasm
0.37	GO:0000785	chromatin
0.37	GO:0070013	intracellular organelle lumen
0.37	GO:0012505	endomembrane system
0.36	GO:0031967	organelle envelope
0.36	GO:0031090	organelle membrane
0.34	GO:0017053	transcriptional repressor complex
0.30	GO:0016021	integral component of membrane

0.51

EC:2.7.11.22

GO:0004693

tr|T1FZE7|T1FZE7_HELRO
Uncharacterized protein
Search

0.37	Carbonic anhydrase

0.62	GO:0036269	swimming behavior
0.55	GO:0006730	one-carbon metabolic process

0.61	GO:0004089	carbonate dehydratase activity
0.49	GO:0008270	zinc ion binding

0.39	GO:0005576	extracellular region
0.34	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.61

EC:4.2.1.1

GO:0004089

tr|T1FZE8|T1FZE8_HELRO
Uncharacterized protein
Search

0.44	Tyrosine-protein kinase transmembrane receptor Ror

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.76	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.66	GO:0038179	neurotrophin signaling pathway
0.53	GO:0061368	behavioral response to formalin induced pain
0.52	GO:0060385	axonogenesis involved in innervation
0.52	GO:1990090	cellular response to nerve growth factor stimulus
0.51	GO:0048485	sympathetic nervous system development
0.51	GO:0046579	positive regulation of Ras protein signal transduction
0.50	GO:0010976	positive regulation of neuron projection development
0.50	GO:0051092	positive regulation of NF-kappaB transcription factor activity

0.78	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.68	GO:0005030	neurotrophin receptor activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.53	GO:0043121	neurotrophin binding
0.47	GO:0042803	protein homodimerization activity
0.38	GO:0005166	neurotrophin p75 receptor binding
0.36	GO:0019900	kinase binding

0.61	GO:0005887	integral component of plasma membrane
0.48	GO:0005769	early endosome
0.48	GO:0005770	late endosome
0.48	GO:0030424	axon
0.48	GO:0043235	receptor complex
0.46	GO:0009986	cell surface
0.37	GO:0010008	endosome membrane
0.37	GO:0120038	plasma membrane bounded cell projection part
0.36	GO:0043025	neuronal cell body
0.36	GO:0097447	dendritic tree

0.78

EC:2.7.10.1

GO:0004714

tr|T1FZE9|T1FZE9_HELRO
DNA topoisomerase 2
Search

TOP2A

0.64	DNA topoisomerase 2-alpha

0.72	GO:0006265	DNA topological change
0.51	GO:0045870	positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
0.50	GO:0030263	apoptotic chromosome condensation
0.50	GO:1905463	negative regulation of DNA duplex unwinding
0.49	GO:0040016	embryonic cleavage
0.47	GO:0002244	hematopoietic progenitor cell differentiation
0.47	GO:0007059	chromosome segregation
0.47	GO:0042752	regulation of circadian rhythm
0.46	GO:0043065	positive regulation of apoptotic process
0.45	GO:0006266	DNA ligation

0.74	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity
0.55	GO:0030554	adenyl nucleotide binding
0.55	GO:0003677	DNA binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0005080	protein kinase C binding
0.47	GO:0042826	histone deacetylase binding
0.47	GO:0008022	protein C-terminus binding
0.46	GO:0043130	ubiquitin binding

0.49	GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)
0.47	GO:0005814	centriole
0.46	GO:0000793	condensed chromosome
0.44	GO:0000228	nuclear chromosome
0.44	GO:0005730	nucleolus
0.43	GO:0005654	nucleoplasm
0.40	GO:0030529	intracellular ribonucleoprotein complex
0.36	GO:0019035	viral integration complex
0.35	GO:0000785	chromatin
0.34	GO:1904949	ATPase complex

0.74

EC:5.99.1.3

GO:0003918

tr|T1FZF0|T1FZF0_HELRO
Uncharacterized protein
Search

0.63	Acyl-CoA-binding domain-containing protein 6

0.40	GO:0071805	potassium ion transmembrane transport
0.39	GO:0006471	protein ADP-ribosylation
0.39	GO:0034765	regulation of ion transmembrane transport
0.37	GO:0016567	protein ubiquitination
0.37	GO:0050968	detection of chemical stimulus involved in sensory perception of pain
0.37	GO:0050955	thermoception
0.37	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
0.36	GO:0048265	response to pain
0.36	GO:0016573	histone acetylation
0.36	GO:0051289	protein homotetramerization

0.72	GO:0000062	fatty-acyl-CoA binding
0.43	GO:0005216	ion channel activity
0.41	GO:0003950	NAD+ ADP-ribosyltransferase activity
0.41	GO:0022836	gated channel activity
0.40	GO:0015079	potassium ion transmembrane transporter activity
0.38	GO:0003723	RNA binding
0.37	GO:0004842	ubiquitin-protein transferase activity
0.37	GO:0004622	lysophospholipase activity
0.36	GO:0004402	histone acetyltransferase activity
0.35	GO:0043531	ADP binding

0.36	GO:0032421	stereocilium bundle
0.35	GO:0005887	integral component of plasma membrane
0.33	GO:0005634	nucleus

0.41	EC:2.4.2.30	GO:0003950
0.37	KEGG:R03876	GO:0004842

tr|T1FZF1|T1FZF1_HELRO
Uncharacterized protein
Search

0.58	Glucocorticoid receptor-like (DNA-binding domain) (Fragment)

0.60	GO:0030221	basophil differentiation
0.60	GO:0030222	eosinophil differentiation
0.58	GO:0030219	megakaryocyte differentiation
0.57	GO:0048821	erythrocyte development
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.52	GO:0010724	regulation of definitive erythrocyte differentiation
0.52	GO:0010725	regulation of primitive erythrocyte differentiation
0.51	GO:0090202	gene looping

0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.51	GO:0070742	C2H2 zinc finger domain binding
0.50	GO:0001085	RNA polymerase II transcription factor binding
0.49	GO:0044212	transcription regulatory region DNA binding
0.49	GO:0008301	DNA binding, bending
0.49	GO:0002039	p53 binding
0.48	GO:0031490	chromatin DNA binding
0.47	GO:0003690	double-stranded DNA binding

0.47	GO:0017053	transcriptional repressor complex
0.47	GO:0005634	nucleus
0.46	GO:0005667	transcription factor complex
0.44	GO:0032993	protein-DNA complex
0.33	GO:0070013	intracellular organelle lumen
0.32	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.34

EC:3.5.1.98

GO:0032041

tr|T1FZF2|T1FZF2_HELRO
Uncharacterized protein
Search

MUS1

0.94	Putative muscarinic acetylcholine receptor (Fragment)

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.66	GO:0095500	acetylcholine receptor signaling pathway
0.41	GO:0007271	synaptic transmission, cholinergic
0.37	GO:0046541	saliva secretion
0.35	GO:0045987	positive regulation of smooth muscle contraction
0.35	GO:0018108	peptidyl-tyrosine phosphorylation
0.35	GO:0050890	cognition
0.35	GO:0006939	smooth muscle contraction
0.34	GO:0097746	regulation of blood vessel diameter
0.34	GO:0040012	regulation of locomotion

0.72	GO:0004930	G-protein coupled receptor activity
0.66	GO:0015464	acetylcholine receptor activity
0.37	GO:0001653	peptide receptor activity
0.35	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.33	GO:0099589	serotonin receptor activity

0.52	GO:0005887	integral component of plasma membrane
0.35	GO:0045202	synapse
0.34	GO:0098590	plasma membrane region
0.34	GO:0030054	cell junction

0.35

GO:0004715

tr|T1FZF3|T1FZF3_HELRO
Uncharacterized protein
Search

tr|T1FZF4|T1FZF4_HELRO
Uncharacterized protein
Search

NECAP1

0.82	Adaptin ear-binding coat-associated protein 1

0.71	GO:0006897	endocytosis
0.37	GO:0015031	protein transport
0.35	GO:0007098	centrosome cycle
0.34	GO:0061024	membrane organization
0.34	GO:1904263	positive regulation of TORC1 signaling
0.34	GO:0016050	vesicle organization
0.34	GO:0006888	ER to Golgi vesicle-mediated transport

0.34	GO:0005515	protein binding
0.32	GO:0005198	structural molecule activity
0.32	GO:0016787	hydrolase activity

0.52	GO:0030665	clathrin-coated vesicle membrane
0.51	GO:0030118	clathrin coat
0.51	GO:0030120	vesicle coat
0.46	GO:0005905	clathrin-coated pit
0.36	GO:0035253	ciliary rootlet
0.35	GO:0005886	plasma membrane
0.34	GO:0008023	transcription elongation factor complex
0.34	GO:0012507	ER to Golgi transport vesicle membrane
0.33	GO:0000139	Golgi membrane
0.33	GO:0005829	cytosol

0.32

GO:0016787

tr|T1FZF5|T1FZF5_HELRO
Uncharacterized protein
Search

tr|T1FZF6|T1FZF6_HELRO
Uncharacterized protein
Search

0.71	LSM domain-containing protein 1-A

0.50

GO:0043066

negative regulation of apoptotic process

0.39	GO:0016740	transferase activity
0.33	GO:0005515	protein binding

0.85	GO:0031417	NatC complex
0.52	GO:0005844	polysome
0.44	GO:0005634	nucleus

0.39

GO:0016740

tr|T1FZF7|T1FZF7_HELRO
Mannosyltransferase
Search

ALG9

0.58	Mannosyltransferase

0.43	GO:0097502	mannosylation
0.34	GO:0006506	GPI anchor biosynthetic process
0.33	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.33	GO:0008408	3'-5' exonuclease activity
0.32	GO:1901265	nucleoside phosphate binding
0.32	GO:0036094	small molecule binding
0.32	GO:0003676	nucleic acid binding

0.72	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.65

GO:0016757

tr|T1FZF8|T1FZF8_HELRO
Uncharacterized protein
Search

0.51	tRNA methyltransferase

0.73	GO:0030488	tRNA methylation
0.46	GO:0007614	short-term memory
0.46	GO:0033313	meiotic cell cycle checkpoint
0.45	GO:0007286	spermatid development
0.45	GO:0070301	cellular response to hydrogen peroxide
0.44	GO:0002101	tRNA wobble cytosine modification
0.43	GO:0048820	hair follicle maturation
0.36	GO:0034220	ion transmembrane transport
0.34	GO:0016573	histone acetylation
0.34	GO:0016567	protein ubiquitination

0.85	GO:0016428	tRNA (cytosine-5-)-methyltransferase activity
0.59	GO:0003723	RNA binding
0.38	GO:0005216	ion channel activity
0.34	GO:0004402	histone acetyltransferase activity
0.34	GO:0004842	ubiquitin-protein transferase activity
0.33	GO:0004386	helicase activity
0.32	GO:0008270	zinc ion binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0003677	DNA binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.47	GO:0033391	chromatoid body
0.46	GO:0005634	nucleus
0.42	GO:0031974	membrane-enclosed lumen
0.39	GO:0044446	intracellular organelle part
0.33	GO:0015630	microtubule cytoskeleton
0.30	GO:0016020	membrane

0.85	EC:2.1.1	GO:0016428
0.34	KEGG:R03876	GO:0004842

tr|T1FZF9|T1FZF9_HELRO
Uncharacterized protein
Search

tr|T1FZG0|T1FZG0_HELRO
Uncharacterized protein
Search

0.19	Carboxylic ester hydrolase

0.35	GO:0097105	presynaptic membrane assembly
0.35	GO:0097104	postsynaptic membrane assembly
0.35	GO:0007158	neuron cell-cell adhesion
0.35	GO:0048488	synaptic vesicle endocytosis
0.34	GO:0050804	modulation of chemical synaptic transmission
0.34	GO:0060179	male mating behavior
0.33	GO:0043043	peptide biosynthetic process
0.33	GO:0044267	cellular protein metabolic process
0.33	GO:0010467	gene expression
0.33	GO:0009059	macromolecule biosynthetic process

0.47	GO:0004104	cholinesterase activity
0.35	GO:0042043	neurexin family protein binding
0.34	GO:0003735	structural constituent of ribosome
0.33	GO:0004872	receptor activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0008270	zinc ion binding
0.32	GO:0022857	transmembrane transporter activity

0.34	GO:0009986	cell surface
0.34	GO:0045202	synapse
0.34	GO:0005840	ribosome
0.33	GO:0005887	integral component of plasma membrane

0.47

EC:3.1.1.8

GO:0004104

tr|T1FZG1|T1FZG1_HELRO
Uncharacterized protein
Search

TSSK1B

0.87	Testis-specific serine/threonine-protein kinase

0.63	GO:0006468	protein phosphorylation
0.46	GO:0007286	spermatid development
0.41	GO:0035556	intracellular signal transduction
0.36	GO:0043066	negative regulation of apoptotic process
0.36	GO:0007275	multicellular organism development
0.34	GO:0007528	neuromuscular junction development
0.32	GO:0006808	regulation of nitrogen utilization
0.32	GO:0015696	ammonium transport
0.32	GO:0006351	transcription, DNA-templated

0.65	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0000287	magnesium ion binding
0.35	GO:0005515	protein binding
0.33	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.32	GO:0003677	DNA binding
0.31	GO:0016787	hydrolase activity

0.42	GO:0031514	motile cilium
0.41	GO:0001669	acrosomal vesicle
0.41	GO:0005634	nucleus
0.39	GO:0005814	centriole
0.30	GO:0031224	intrinsic component of membrane

0.65

GO:0004674

tr|T1FZG2|T1FZG2_HELRO
Uncharacterized protein
Search

0.48	GO:1903506	regulation of nucleic acid-templated transcription
0.48	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.47	GO:0010468	regulation of gene expression
0.36	GO:0043046	DNA methylation involved in gamete generation
0.36	GO:0071514	genetic imprinting
0.36	GO:0051569	regulation of histone H3-K4 methylation
0.36	GO:0006351	transcription, DNA-templated
0.35	GO:0016571	histone methylation
0.35	GO:1902680	positive regulation of RNA biosynthetic process
0.34	GO:0071222	cellular response to lipopolysaccharide

0.51	GO:0003676	nucleic acid binding
0.47	GO:0046872	metal ion binding
0.38	GO:0003700	DNA binding transcription factor activity
0.35	GO:0042393	histone binding
0.33	GO:0046983	protein dimerization activity
0.32	GO:0016874	ligase activity

0.41	GO:0005634	nucleus
0.38	GO:0005829	cytosol
0.38	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016874

tr|T1FZG3|T1FZG3_HELRO
Uncharacterized protein
Search

tr|T1FZG4|T1FZG4_HELRO
Uncharacterized protein
Search

0.46	GO:0007166	cell surface receptor signaling pathway
0.44	GO:0007186	G-protein coupled receptor signaling pathway
0.43	GO:0061036	positive regulation of cartilage development
0.42	GO:0032502	developmental process
0.41	GO:0032501	multicellular organismal process
0.41	GO:0006508	proteolysis
0.41	GO:0007155	cell adhesion
0.39	GO:0003250	regulation of cell proliferation involved in heart valve morphogenesis
0.36	GO:0006030	chitin metabolic process
0.36	GO:0030198	extracellular matrix organization

0.70	GO:0005509	calcium ion binding
0.54	GO:0005201	extracellular matrix structural constituent
0.44	GO:0004930	G-protein coupled receptor activity
0.44	GO:0004222	metalloendopeptidase activity
0.41	GO:0008270	zinc ion binding
0.40	GO:0042802	identical protein binding
0.38	GO:0050436	microfibril binding
0.36	GO:0050431	transforming growth factor beta binding
0.36	GO:0008061	chitin binding
0.34	GO:0098772	molecular function regulator

0.52	GO:0044421	extracellular region part
0.36	GO:0009986	cell surface
0.35	GO:0099512	supramolecular fiber
0.34	GO:0043234	protein complex
0.34	GO:0031982	vesicle
0.33	GO:0005794	Golgi apparatus
0.33	GO:0005886	plasma membrane
0.32	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.44

GO:0004222

tr|T1FZG5|T1FZG5_HELRO
Uncharacterized protein
Search

KLHDC3

0.51	Kelch domain-containing protein 3

0.56	GO:0000469	cleavage involved in rRNA processing
0.39	GO:0051321	meiotic cell cycle
0.36	GO:0036498	IRE1-mediated unfolded protein response
0.35	GO:0035825	homologous recombination
0.35	GO:0000280	nuclear division
0.34	GO:0022402	cell cycle process
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression

0.62	GO:0003682	chromatin binding
0.35	GO:0005515	protein binding

0.60	GO:0000790	nuclear chromatin
0.56	GO:0005654	nucleoplasm
0.50	GO:0005730	nucleolus
0.43	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1FZG6|T1FZG6_HELRO
Uncharacterized protein
Search

tr|T1FZG7|T1FZG7_HELRO
Uncharacterized protein
Search

NME7

0.41	Nucleoside diphosphate kinase

0.75	GO:0006228	UTP biosynthetic process
0.75	GO:0006183	GTP biosynthetic process
0.72	GO:0046036	CTP metabolic process
0.70	GO:0006165	nucleoside diphosphate phosphorylation
0.38	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway
0.37	GO:0003351	epithelial cilium movement
0.37	GO:0060972	left/right pattern formation
0.37	GO:1990823	response to leukemia inhibitory factor
0.37	GO:0042073	intraciliary transport
0.37	GO:0007368	determination of left/right symmetry

0.79	GO:0004550	nucleoside diphosphate kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding
0.32	GO:0003777	microtubule motor activity
0.32	GO:0016887	ATPase activity

0.51	GO:0005813	centrosome
0.37	GO:0036064	ciliary basal body
0.34	GO:0005829	cytosol
0.33	GO:0005858	axonemal dynein complex
0.30	GO:0016020	membrane

0.79

EC:2.7.4.6

GO:0004550

tr|T1FZG8|T1FZG8_HELRO
Uncharacterized protein
Search

tr|T1FZG9|T1FZG9_HELRO
Uncharacterized protein
Search

tr|T1FZH0|T1FZH0_HELRO
Uncharacterized protein
Search

tr|T1FZH1|T1FZH1_HELRO
Uncharacterized protein
Search

0.59	GO:0036023	embryonic skeletal limb joint morphogenesis
0.58	GO:0048389	intermediate mesoderm development
0.58	GO:0001822	kidney development
0.57	GO:0042474	middle ear morphogenesis
0.57	GO:0035116	embryonic hindlimb morphogenesis
0.57	GO:0035115	embryonic forelimb morphogenesis
0.56	GO:0010470	regulation of gastrulation
0.56	GO:0030501	positive regulation of bone mineralization
0.56	GO:1905407	regulation of creatine transmembrane transporter activity
0.56	GO:0072183	negative regulation of nephron tubule epithelial cell differentiation

0.51	GO:0003676	nucleic acid binding
0.50	GO:0019901	protein kinase binding
0.46	GO:0004674	protein serine/threonine kinase activity
0.43	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.42	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.36	GO:0046872	metal ion binding

0.46	GO:0005634	nucleus
0.36	GO:0019898	extrinsic component of membrane
0.35	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.46

GO:0004674

tr|T1FZH2|T1FZH2_HELRO
Uncharacterized protein
Search

DROSHA

0.37	Drosha ribonuclease III

0.76	GO:0016075	rRNA catabolic process
0.70	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.63	GO:0006396	RNA processing
0.52	GO:0071359	cellular response to dsRNA
0.52	GO:0035195	gene silencing by miRNA
0.46	GO:0030727	germarium-derived female germ-line cyst formation
0.46	GO:0007294	germarium-derived oocyte fate determination
0.46	GO:0035070	salivary gland histolysis
0.46	GO:0016319	mushroom body development
0.45	GO:2000628	regulation of miRNA metabolic process

0.78	GO:0032296	double-stranded RNA-specific ribonuclease activity
0.72	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters
0.58	GO:0003723	RNA binding
0.45	GO:0017151	DEAD/H-box RNA helicase binding
0.45	GO:0070412	R-SMAD binding
0.43	GO:0001530	lipopolysaccharide binding
0.41	GO:0042803	protein homodimerization activity
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding

0.53	GO:0070877	microprocessor complex
0.44	GO:0014069	postsynaptic density
0.35	GO:0005730	nucleolus
0.33	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.72

EC:3.1.26

GO:0016891

tr|T1FZH3|T1FZH3_HELRO
Uncharacterized protein
Search

0.37	Mitochondrial methionyl-tRNA formyltransferase

0.74	GO:0071951	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA
0.67	GO:0006413	translational initiation
0.33	GO:0006189	'de novo' IMP biosynthetic process

0.74	GO:0004479	methionyl-tRNA formyltransferase activity
0.34	GO:0004644	phosphoribosylglycinamide formyltransferase activity

0.74

EC:2.1.2.9

GO:0004479

tr|T1FZH4|T1FZH4_HELRO
Uncharacterized protein
Search

0.25	Mediator of RNA polymerase II transcription subunit 11

0.70	GO:0006357	regulation of transcription by RNA polymerase II
0.58	GO:0006351	transcription, DNA-templated

0.79

GO:0001104

RNA polymerase II transcription cofactor activity

0.77

GO:0016592

mediator complex

tr|T1FZH5|T1FZH5_HELRO
Uncharacterized protein
Search

0.54	Branched-chain-amino-acid aminotransferase

0.70	GO:0009081	branched-chain amino acid metabolic process
0.62	GO:0008652	cellular amino acid biosynthetic process
0.38	GO:1901605	alpha-amino acid metabolic process
0.33	GO:0016192	vesicle-mediated transport

0.79	GO:0052654	L-leucine transaminase activity
0.79	GO:0052655	L-valine transaminase activity
0.79	GO:0052656	L-isoleucine transaminase activity

0.38	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.79	EC:2.6.1.42	GO:0052654
0.79	KEGG:R01090	GO:0052654

tr|T1FZH6|T1FZH6_HELRO
Uncharacterized protein
Search

DROSHA

0.52	Drosha ribonucleaseIII (Fragment)

0.77	GO:0016075	rRNA catabolic process
0.70	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.63	GO:0006396	RNA processing
0.55	GO:0071359	cellular response to dsRNA
0.55	GO:0035195	gene silencing by miRNA
0.54	GO:2000628	regulation of miRNA metabolic process
0.53	GO:0045589	regulation of regulatory T cell differentiation
0.53	GO:0010586	miRNA metabolic process
0.52	GO:0050830	defense response to Gram-positive bacterium
0.51	GO:0050829	defense response to Gram-negative bacterium

0.78	GO:0032296	double-stranded RNA-specific ribonuclease activity
0.72	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters
0.59	GO:0003723	RNA binding
0.54	GO:0017151	DEAD/H-box RNA helicase binding
0.53	GO:0070412	R-SMAD binding
0.51	GO:0001530	lipopolysaccharide binding
0.48	GO:0042803	protein homodimerization activity
0.33	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.33	GO:0046872	metal ion binding

0.55	GO:0070877	microprocessor complex
0.51	GO:0014069	postsynaptic density
0.35	GO:0005730	nucleolus
0.33	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.72

EC:3.1.26

GO:0016891

tr|T1FZH7|T1FZH7_HELRO
Uncharacterized protein
Search

tr|T1FZH8|T1FZH8_HELRO
Uncharacterized protein
Search

0.86	VHSV-induced protein (Fragment)

0.53	GO:2001141	regulation of RNA biosynthetic process
0.43	GO:0051254	positive regulation of RNA metabolic process
0.43	GO:0010557	positive regulation of macromolecule biosynthetic process
0.43	GO:0031328	positive regulation of cellular biosynthetic process
0.43	GO:0010628	positive regulation of gene expression
0.40	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0019216	regulation of lipid metabolic process
0.34	GO:0033567	DNA replication, Okazaki fragment processing
0.34	GO:0043244	regulation of protein complex disassembly
0.33	GO:0034248	regulation of cellular amide metabolic process

0.77	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
0.51	GO:0004386	helicase activity
0.41	GO:0046872	metal ion binding
0.39	GO:0003676	nucleic acid binding
0.36	GO:0003700	DNA binding transcription factor activity
0.34	GO:0004519	endonuclease activity
0.34	GO:0043142	single-stranded DNA-dependent ATPase activity
0.34	GO:0140097	catalytic activity, acting on DNA
0.33	GO:0047750	cholestenol delta-isomerase activity
0.33	GO:0005515	protein binding

0.37	GO:0005634	nucleus
0.35	GO:0036464	cytoplasmic ribonucleoprotein granule
0.34	GO:0005844	polysome
0.33	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.32	GO:0005829	cytosol
0.32	GO:0097014	ciliary plasm
0.32	GO:0005856	cytoskeleton
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.33	EC:5.3.3.5	GO:0047750
0.33	KEGG:R07290	GO:0033608

tr|T1FZH9|T1FZH9_HELRO
Uncharacterized protein
Search

0.78	Glycogen synthase kinase

0.63	GO:0006468	protein phosphorylation
0.50	GO:0071109	superior temporal gyrus development
0.49	GO:0051534	negative regulation of NFAT protein import into nucleus
0.49	GO:1904781	positive regulation of protein localization to centrosome
0.49	GO:0006983	ER overload response
0.48	GO:0010822	positive regulation of mitochondrion organization
0.48	GO:0001954	positive regulation of cell-matrix adhesion
0.48	GO:0046827	positive regulation of protein export from nucleus
0.48	GO:1901216	positive regulation of neuron death
0.48	GO:0009888	tissue development

0.68	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.49	GO:0034452	dynactin binding
0.49	GO:0050321	tau-protein kinase activity
0.48	GO:0051059	NF-kappaB binding
0.48	GO:0034236	protein kinase A catalytic subunit binding
0.47	GO:0002039	p53 binding

0.48	GO:0030877	beta-catenin destruction complex
0.45	GO:0005813	centrosome
0.40	GO:0005634	nucleus
0.38	GO:0005886	plasma membrane
0.37	GO:1990909	Wnt signalosome
0.36	GO:0043198	dendritic shaft
0.36	GO:0030426	growth cone
0.36	GO:0014069	postsynaptic density
0.35	GO:0043025	neuronal cell body
0.35	GO:0005739	mitochondrion

0.68

GO:0004674

tr|T1FZI0|T1FZI0_HELRO
Uncharacterized protein
Search

0.38	Pre-mRNA branch site protein p14

0.50	GO:0001825	blastocyst formation
0.49	GO:0000398	mRNA splicing, via spliceosome
0.44	GO:0006030	chitin metabolic process
0.33	GO:0006414	translational elongation

0.59	GO:0003723	RNA binding
0.44	GO:0008061	chitin binding
0.34	GO:0004045	aminoacyl-tRNA hydrolase activity
0.33	GO:0005515	protein binding

0.53	GO:0005689	U12-type spliceosomal complex
0.46	GO:0071011	precatalytic spliceosome
0.45	GO:0005686	U2 snRNP
0.45	GO:0071013	catalytic step 2 spliceosome
0.45	GO:0005684	U2-type spliceosomal complex
0.41	GO:0005576	extracellular region
0.34	GO:0005853	eukaryotic translation elongation factor 1 complex
0.33	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.34

EC:3.1.1.29

GO:0004045

tr|T1FZI1|T1FZI1_HELRO
Uncharacterized protein
Search

tr|T1FZI2|T1FZI2_HELRO
Uncharacterized protein
Search

HECTD2

0.92	HECT domain containing 2

0.73

GO:0016567

protein ubiquitination

0.74	GO:0004842	ubiquitin-protein transferase activity
0.51	GO:0061659	ubiquitin-like protein ligase activity

0.39	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.74

GO:0004842

tr|T1FZI3|T1FZI3_HELRO
Uncharacterized protein
Search

0.46	Glucosamine-phosphate N-acetyltransferase

0.42	GO:0006048	UDP-N-acetylglucosamine biosynthetic process
0.37	GO:0030148	sphingolipid biosynthetic process
0.36	GO:0006397	mRNA processing
0.33	GO:0055114	oxidation-reduction process

0.68	GO:0008080	N-acetyltransferase activity
0.37	GO:0042284	sphingolipid delta-4 desaturase activity
0.34	GO:0003723	RNA binding

0.35	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.68

GO:0008080

tr|T1FZI4|T1FZI4_HELRO
Uncharacterized protein
Search

MAB21L1

0.95	Mab-21 like 1

0.81	GO:0043010	camera-type eye development
0.79	GO:0008284	positive regulation of cell proliferation
0.42	GO:0010172	embryonic body morphogenesis

0.61	GO:0005634	nucleus
0.34	GO:0005737	cytoplasm

tr|T1FZI5|T1FZI5_HELRO
Kinesin-like protein
Search

0.40	Kinesin-II 95 kDa subunit

0.81	GO:0030705	cytoskeleton-dependent intracellular transport
0.74	GO:0007018	microtubule-based movement

0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.61	GO:0016887	ATPase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.81	GO:0005871	kinesin complex
0.73	GO:0005874	microtubule
0.49	GO:0005737	cytoplasm

0.61

GO:0016887

tr|T1FZI6|T1FZI6_HELRO
Uncharacterized protein
Search

tr|T1FZI7|T1FZI7_HELRO
Uncharacterized protein
Search

RNF146

0.40	Zinc finger protein (Fragment)

0.77	GO:0016055	Wnt signaling pathway
0.73	GO:0016567	protein ubiquitination
0.55	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.50	GO:0006511	ubiquitin-dependent protein catabolic process
0.41	GO:0031648	protein destabilization
0.34	GO:0016579	protein deubiquitination
0.33	GO:0006281	DNA repair
0.32	GO:0006355	regulation of transcription, DNA-templated

0.86	GO:0072572	poly-ADP-D-ribose binding
0.76	GO:0061630	ubiquitin protein ligase activity
0.63	GO:0008270	zinc ion binding
0.51	GO:0016874	ligase activity
0.34	GO:0005515	protein binding
0.33	GO:0003700	DNA binding transcription factor activity

0.48	GO:0005829	cytosol
0.46	GO:0005654	nucleoplasm
0.40	GO:0005886	plasma membrane
0.33	GO:0042025	host cell nucleus
0.30	GO:0031224	intrinsic component of membrane

0.51

GO:0016874

tr|T1FZI8|T1FZI8_HELRO
Uridine kinase
Search

0.51	Uridine-cytidine kinase

0.80	GO:0044211	CTP salvage
0.76	GO:0044206	UMP salvage
0.57	GO:0016310	phosphorylation
0.40	GO:0006206	pyrimidine nucleobase metabolic process

0.80	GO:0004849	uridine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003676	nucleic acid binding

0.39	GO:0005829	cytosol
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.80

EC:2.7.1.48

GO:0004849

tr|T1FZI9|T1FZI9_HELRO
Uncharacterized protein
Search

tr|T1FZJ0|T1FZJ0_HELRO
Uncharacterized protein
Search

ABCG4

0.81	ATP-binding cassette sub-family G member 1

0.61	GO:0030301	cholesterol transport
0.58	GO:0032366	intracellular sterol transport
0.52	GO:1990823	response to leukemia inhibitory factor
0.51	GO:0034436	glycoprotein transport
0.50	GO:0033700	phospholipid efflux
0.50	GO:0071403	cellular response to high density lipoprotein particle stimulus
0.50	GO:0055091	phospholipid homeostasis
0.50	GO:0042987	amyloid precursor protein catabolic process
0.49	GO:0071345	cellular response to cytokine stimulus
0.49	GO:0010874	regulation of cholesterol efflux

0.63	GO:0017127	cholesterol transporter activity
0.60	GO:0016887	ATPase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0042803	protein homodimerization activity
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0046982	protein heterodimerization activity
0.52	GO:1901618	organic hydroxy compound transmembrane transporter activity
0.51	GO:0034437	glycoprotein transporter activity
0.47	GO:0019534	toxin transmembrane transporter activity

0.47	GO:0009897	external side of plasma membrane
0.46	GO:0055037	recycling endosome
0.40	GO:0005739	mitochondrion
0.35	GO:0005794	Golgi apparatus
0.30	GO:0016021	integral component of membrane

0.60

GO:0016887

tr|T1FZJ1|T1FZJ1_HELRO
Uncharacterized protein
Search

0.36	GO:0070647	protein modification by small protein conjugation or removal
0.35	GO:0007186	G-protein coupled receptor signaling pathway
0.34	GO:0006270	DNA replication initiation
0.33	GO:0006508	proteolysis
0.33	GO:0016192	vesicle-mediated transport
0.33	GO:0006351	transcription, DNA-templated
0.32	GO:0006355	regulation of transcription, DNA-templated
0.32	GO:0055085	transmembrane transport

0.35	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.34	GO:0031683	G-protein beta/gamma-subunit complex binding
0.34	GO:0004842	ubiquitin-protein transferase activity
0.34	GO:0004983	neuropeptide Y receptor activity
0.33	GO:0017076	purine nucleotide binding
0.33	GO:0003924	GTPase activity
0.33	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor
0.33	GO:0003677	DNA binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0003700	DNA binding transcription factor activity

0.34	GO:0000325	plant-type vacuole
0.34	GO:0030008	TRAPP complex
0.33	GO:0005774	vacuolar membrane
0.33	GO:0009507	chloroplast
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.33	EC:6.3.5	GO:0016884
0.34	KEGG:R03876	GO:0004842

tr|T1FZJ2|T1FZJ2_HELRO
Uncharacterized protein
Search

tr|T1FZJ3|T1FZJ3_HELRO
Uncharacterized protein
Search

0.53	GO:0006364	rRNA processing
0.39	GO:0042274	ribosomal small subunit biogenesis
0.37	GO:0006468	protein phosphorylation
0.37	GO:0032259	methylation

0.49	GO:0003723	RNA binding
0.43	GO:0032559	adenyl ribonucleotide binding
0.42	GO:0043168	anion binding
0.42	GO:0008144	drug binding
0.37	GO:0004672	protein kinase activity
0.37	GO:0043565	sequence-specific DNA binding
0.37	GO:0008168	methyltransferase activity
0.36	GO:0016874	ligase activity

0.60	GO:0032040	small-subunit processome
0.42	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome
0.38	GO:0019013	viral nucleocapsid
0.30	GO:0016020	membrane

0.37

GO:0008168

tr|T1FZJ4|T1FZJ4_HELRO
Uncharacterized protein
Search

MAD2L1

0.86	Spindle assembly checkpoint component

0.83	GO:0007094	mitotic spindle assembly checkpoint
0.50	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint
0.50	GO:1904667	negative regulation of ubiquitin protein ligase activity
0.49	GO:0051312	chromosome decondensation
0.49	GO:1905318	meiosis I spindle assembly checkpoint
0.49	GO:1990492	mitotic cell cycle checkpoint inhibiting CAR assembly
0.49	GO:0072416	signal transduction involved in spindle checkpoint
0.48	GO:0042177	negative regulation of protein catabolic process
0.48	GO:0072413	signal transduction involved in mitotic cell cycle checkpoint
0.47	GO:0044774	mitotic DNA integrity checkpoint

0.47	GO:0010997	anaphase-promoting complex binding
0.45	GO:0042803	protein homodimerization activity
0.34	GO:0003677	DNA binding

0.53	GO:0072686	mitotic spindle
0.53	GO:0000776	kinetochore
0.52	GO:0005643	nuclear pore
0.49	GO:0033597	mitotic checkpoint complex
0.48	GO:0031981	nuclear lumen
0.47	GO:0000779	condensed chromosome, centromeric region
0.47	GO:0044732	mitotic spindle pole body
0.47	GO:0048471	perinuclear region of cytoplasm
0.46	GO:0005876	spindle microtubule
0.43	GO:0000785	chromatin

tr|T1FZJ5|T1FZJ5_HELRO
Palmitoyltransferase
Search

0.55	Palmitoyltransferase

0.40	GO:0018345	protein palmitoylation
0.35	GO:1903830	magnesium ion transmembrane transport
0.34	GO:0006506	GPI anchor biosynthetic process
0.34	GO:0097502	mannosylation
0.33	GO:0016079	synaptic vesicle exocytosis
0.33	GO:0050714	positive regulation of protein secretion
0.33	GO:0007283	spermatogenesis

0.76	GO:0019706	protein-cysteine S-palmitoyltransferase activity
0.35	GO:0015095	magnesium ion transmembrane transporter activity
0.34	GO:0000030	mannosyltransferase activity

0.38	GO:0005783	endoplasmic reticulum
0.35	GO:0031501	mannosyltransferase complex
0.34	GO:0031984	organelle subcompartment
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.33	GO:0042734	presynaptic membrane
0.33	GO:0008021	synaptic vesicle
0.32	GO:0030054	cell junction
0.32	GO:0044431	Golgi apparatus part
0.32	GO:0098588	bounding membrane of organelle
0.30	GO:0031224	intrinsic component of membrane

0.76

EC:2.3.1.225

GO:0019706

tr|T1FZJ6|T1FZJ6_HELRO
Uncharacterized protein
Search

0.86	Ret proto-oncoprotein (Fragment)

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.51	GO:0061146	Peyer's patch morphogenesis
0.51	GO:0035799	ureter maturation
0.51	GO:0072300	positive regulation of metanephric glomerulus development
0.51	GO:0098609	cell-cell adhesion
0.50	GO:0048484	enteric nervous system development
0.50	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
0.50	GO:0001755	neural crest cell migration
0.49	GO:0033630	positive regulation of cell adhesion mediated by integrin
0.49	GO:0048265	response to pain

0.77	GO:0004713	protein tyrosine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0019199	transmembrane receptor protein kinase activity
0.50	GO:0005509	calcium ion binding
0.39	GO:0005515	protein binding
0.38	GO:0003777	microtubule motor activity
0.35	GO:0008376	acetylgalactosaminyltransferase activity

0.51	GO:0098857	membrane microdomain
0.46	GO:0043235	receptor complex
0.46	GO:0010008	endosome membrane
0.43	GO:0005829	cytosol
0.43	GO:0044459	plasma membrane part
0.41	GO:0098796	membrane protein complex
0.39	GO:0098562	cytoplasmic side of membrane
0.39	GO:0019898	extrinsic component of membrane
0.39	GO:0043231	intracellular membrane-bounded organelle
0.36	GO:0043025	neuronal cell body

0.77

GO:0004713

tr|T1FZJ7|T1FZJ7_HELRO
Uncharacterized protein
Search

0.65	Voltage-dependent calcium channel type A subunit alpha-1

0.77	GO:0070588	calcium ion transmembrane transport
0.74	GO:0034765	regulation of ion transmembrane transport
0.47	GO:0035545	determination of left/right asymmetry in nervous system
0.45	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.44	GO:0007626	locomotory behavior
0.43	GO:0042594	response to starvation
0.42	GO:0009408	response to heat
0.41	GO:0001505	regulation of neurotransmitter levels
0.40	GO:0086010	membrane depolarization during action potential

0.82	GO:0005245	voltage-gated calcium channel activity
0.66	GO:0005509	calcium ion binding

0.81	GO:0005891	voltage-gated calcium channel complex
0.47	GO:0048787	presynaptic active zone membrane

tr|T1FZJ8|T1FZJ8_HELRO
Uncharacterized protein
Search

MTG2

0.42	Mitochondrial ribosome-associated GTPase

0.49	GO:0044065	regulation of respiratory system process
0.48	GO:0070129	regulation of mitochondrial translation
0.38	GO:0042254	ribosome biogenesis
0.32	GO:1903506	regulation of nucleic acid-templated transcription

0.66	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.63	GO:0000287	magnesium ion binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0003713	transcription coactivator activity
0.33	GO:0003723	RNA binding

0.45	GO:0005761	mitochondrial ribosome
0.40	GO:0031966	mitochondrial membrane
0.40	GO:0019866	organelle inner membrane
0.35	GO:0005680	anaphase-promoting complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZJ9|T1FZJ9_HELRO
Uncharacterized protein
Search

SCRT1

0.58	Transcriptional repressor scratch 1

0.36

GO:0000122

negative regulation of transcription by RNA polymerase II

0.51	GO:0003676	nucleic acid binding
0.37	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.35	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding

0.42	GO:0000228	nuclear chromosome
0.35	GO:0005667	transcription factor complex
0.34	GO:0016604	nuclear body
0.30	GO:0016020	membrane

tr|T1FZK0|T1FZK0_HELRO
Uncharacterized protein
Search

0.72	Putative 52 kDa repressor of the inhibitor of the protein kinase (Fragment)

0.57

GO:0016310

phosphorylation

0.67	GO:0046983	protein dimerization activity
0.60	GO:0016301	kinase activity

tr|T1FZK1|T1FZK1_HELRO
Uncharacterized protein
Search

tr|T1FZK2|T1FZK2_HELRO
Uncharacterized protein
Search

RPL7A

0.72	Ribosomal protein L7a

0.64	GO:0042254	ribosome biogenesis
0.41	GO:0016072	rRNA metabolic process
0.40	GO:0034470	ncRNA processing
0.39	GO:0043043	peptide biosynthetic process
0.38	GO:0044267	cellular protein metabolic process
0.37	GO:0009059	macromolecule biosynthetic process
0.36	GO:1904401	cellular response to Thyroid stimulating hormone
0.34	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.34	GO:0019083	viral transcription

0.42	GO:0045296	cadherin binding
0.39	GO:0003723	RNA binding
0.34	GO:0003735	structural constituent of ribosome

0.61	GO:0030529	intracellular ribonucleoprotein complex
0.55	GO:0043232	intracellular non-membrane-bounded organelle
0.51	GO:0044444	cytoplasmic part
0.38	GO:0044446	intracellular organelle part
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.34	GO:0031974	membrane-enclosed lumen
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZK3|T1FZK3_HELRO
Uncharacterized protein
Search

0.55	Phosphodiesterase

0.61	GO:0007165	signal transduction
0.40	GO:0007608	sensory perception of smell
0.38	GO:0046069	cGMP catabolic process
0.37	GO:0010754	negative regulation of cGMP-mediated signaling
0.36	GO:0010035	response to inorganic substance
0.36	GO:0090038	negative regulation of protein kinase C signaling
0.36	GO:0032528	microvillus organization
0.36	GO:0010446	response to alkaline pH
0.36	GO:0007635	chemosensory behavior
0.36	GO:0008340	determination of adult lifespan

0.80	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.54	GO:0046872	metal ion binding
0.37	GO:0005516	calmodulin binding
0.34	GO:0030552	cAMP binding

0.40	GO:0005929	cilium
0.34	GO:0043025	neuronal cell body
0.30	GO:0016020	membrane

0.80

EC:3.1.4.17

GO:0004114

tr|T1FZK4|T1FZK4_HELRO
Arginase
Search

ARG2

0.57	Ureohydrolase

0.71	GO:0006525	arginine metabolic process
0.68	GO:0000050	urea cycle
0.52	GO:0071643	regulation of chemokine (C-C motif) ligand 4 production
0.52	GO:1905403	negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
0.52	GO:1905077	negative regulation of interleukin-17 secretion
0.52	GO:0071641	negative regulation of macrophage inflammatory protein 1 alpha production
0.52	GO:2000666	negative regulation of interleukin-13 secretion
0.52	GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production
0.52	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation
0.51	GO:1904468	negative regulation of tumor necrosis factor secretion

0.83	GO:0004053	arginase activity
0.54	GO:0046872	metal ion binding
0.35	GO:0090369	ornithine carbamoyltransferase inhibitor activity
0.33	GO:0004003	ATP-dependent DNA helicase activity
0.33	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
0.33	GO:0050660	flavin adenine dinucleotide binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0003677	DNA binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.41	GO:0005739	mitochondrion
0.34	GO:0043025	neuronal cell body
0.34	GO:0070062	extracellular exosome
0.34	GO:0043005	neuron projection
0.34	GO:0031968	organelle outer membrane
0.34	GO:0005634	nucleus
0.33	GO:0005829	cytosol

0.83

EC:3.5.3.1

GO:0004053

tr|T1FZK5|T1FZK5_HELRO
Uncharacterized protein
Search

ELMOD1

0.87	Engulfment and cell motility

0.68	GO:0043547	positive regulation of GTPase activity
0.42	GO:0090175	regulation of establishment of planar polarity
0.41	GO:0000281	mitotic cytokinesis
0.40	GO:1903955	positive regulation of protein targeting to mitochondrion
0.39	GO:0031647	regulation of protein stability
0.35	GO:0050688	regulation of defense response to virus

0.68	GO:0005096	GTPase activator activity
0.34	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
0.32	GO:0008270	zinc ion binding

0.38	GO:0005654	nucleoplasm
0.37	GO:0005829	cytosol
0.33	GO:0008250	oligosaccharyltransferase complex
0.30	GO:0031224	intrinsic component of membrane

0.34

EC:2.4.1.119

GO:0004579

tr|T1FZK6|T1FZK6_HELRO
Uncharacterized protein
Search

0.50	GO:0006468	protein phosphorylation
0.41	GO:0007411	axon guidance
0.41	GO:0009966	regulation of signal transduction
0.40	GO:0045663	positive regulation of myoblast differentiation
0.40	GO:0007155	cell adhesion
0.40	GO:0007166	cell surface receptor signaling pathway
0.38	GO:0065009	regulation of molecular function
0.38	GO:0023056	positive regulation of signaling
0.38	GO:0010647	positive regulation of cell communication
0.37	GO:0048584	positive regulation of response to stimulus

0.50	GO:0004672	protein kinase activity
0.48	GO:0005509	calcium ion binding
0.45	GO:0030554	adenyl nucleotide binding
0.44	GO:0097367	carbohydrate derivative binding
0.44	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0008144	drug binding
0.38	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.36	GO:0004860	protein kinase inhibitor activity
0.36	GO:0004872	receptor activity
0.36	GO:0005178	integrin binding

0.47	GO:0005604	basement membrane
0.45	GO:0005938	cell cortex
0.44	GO:0030054	cell junction
0.39	GO:0005887	integral component of plasma membrane
0.35	GO:0098857	membrane microdomain
0.35	GO:0016604	nuclear body
0.35	GO:0005768	endosome
0.34	GO:0005794	Golgi apparatus
0.34	GO:0005783	endoplasmic reticulum
0.34	GO:0005829	cytosol

tr|T1FZK7|T1FZK7_HELRO
Uncharacterized protein
Search

0.53	Zinc finger MYM-type protein 1

0.68

GO:0046983

protein dimerization activity

0.30

GO:0044425

membrane part

tr|T1FZK8|T1FZK8_HELRO
Uncharacterized protein
Search

SCPEP1

0.52	Retinoid-inducible serine carboxypeptidase

0.60	GO:0006508	proteolysis
0.43	GO:0045776	negative regulation of blood pressure
0.42	GO:0097755	positive regulation of blood vessel diameter
0.41	GO:0044257	cellular protein catabolic process
0.38	GO:0042573	retinoic acid metabolic process
0.33	GO:0006915	apoptotic process
0.33	GO:0007034	vacuolar transport
0.32	GO:0006310	DNA recombination
0.32	GO:0006281	DNA repair

0.73

GO:0004185

serine-type carboxypeptidase activity

0.35	GO:0005829	cytosol
0.35	GO:0005576	extracellular region
0.34	GO:0031982	vesicle
0.33	GO:0005794	Golgi apparatus
0.30	GO:0016020	membrane

0.73

EC:3.4.16

GO:0004185

tr|T1FZK9|T1FZK9_HELRO
Uncharacterized protein
Search

0.77	GO:0016055	Wnt signaling pathway
0.55	GO:0006357	regulation of transcription by RNA polymerase II
0.34	GO:0035462	determination of left/right asymmetry in diencephalon
0.34	GO:0021986	habenula development
0.34	GO:0060729	intestinal epithelial structure maintenance
0.34	GO:0010226	response to lithium ion
0.34	GO:0002681	somatic recombination of T cell receptor gene segments
0.34	GO:0071353	cellular response to interleukin-4
0.34	GO:0048546	digestive tract morphogenesis
0.33	GO:0033151	V(D)J recombination

0.63	GO:0008013	beta-catenin binding
0.55	GO:0003677	DNA binding
0.36	GO:0001067	regulatory region nucleic acid binding

0.61	GO:0005634	nucleus
0.36	GO:0005667	transcription factor complex
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

tr|T1FZL0|T1FZL0_HELRO
Uncharacterized protein
Search

0.37	ATP-dependent DNA helicase

0.68	GO:0032392	DNA geometric change
0.65	GO:0006310	DNA recombination
0.64	GO:0006260	DNA replication
0.63	GO:0006281	DNA repair
0.46	GO:1901291	negative regulation of double-strand break repair via single-strand annealing
0.43	GO:0007127	meiosis I
0.39	GO:0071897	DNA biosynthetic process
0.37	GO:0045950	negative regulation of mitotic recombination
0.34	GO:0009432	SOS response
0.34	GO:0006421	asparaginyl-tRNA aminoacylation

0.77	GO:0043140	ATP-dependent 3'-5' DNA helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.39	GO:0009378	four-way junction helicase activity
0.34	GO:0004816	asparagine-tRNA ligase activity
0.33	GO:0008234	cysteine-type peptidase activity
0.32	GO:0046872	metal ion binding

0.48	GO:0005634	nucleus
0.37	GO:0005694	chromosome
0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.34	EC:6.1.1.22	GO:0004816
0.34	KEGG:R03648	GO:0004816

tr|T1FZL1|T1FZL1_HELRO
Uncharacterized protein
Search

0.59	Acidic repeat-containing protein (Fragment)

0.65	GO:0080111	DNA demethylation
0.41	GO:0007218	neuropeptide signaling pathway
0.40	GO:0045132	meiotic chromosome segregation

0.43	GO:0003677	DNA binding
0.39	GO:0004930	G-protein coupled receptor activity

0.50	GO:0005634	nucleus
0.39	GO:0000793	condensed chromosome
0.30	GO:0044425	membrane part

tr|T1FZL2|T1FZL2_HELRO
Uncharacterized protein
Search

0.49	Zinc finger MYM-type protein 1

0.68

GO:0046983

protein dimerization activity

tr|T1FZL3|T1FZL3_HELRO
Uncharacterized protein
Search

tr|T1FZL4|T1FZL4_HELRO
Uncharacterized protein
Search

0.83	Hepatocyte nuclear factor 4-alpha

0.79	GO:0043401	steroid hormone mediated signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0030522	intracellular receptor signaling pathway
0.44	GO:0051254	positive regulation of RNA metabolic process
0.44	GO:0010557	positive regulation of macromolecule biosynthetic process
0.44	GO:0031328	positive regulation of cellular biosynthetic process
0.38	GO:2000189	positive regulation of cholesterol homeostasis

0.80	GO:0003707	steroid hormone receptor activity
0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.46	GO:0001012	RNA polymerase II regulatory region DNA binding
0.44	GO:0003690	double-stranded DNA binding
0.37	GO:0005504	fatty acid binding
0.37	GO:0001102	RNA polymerase II activating transcription factor binding
0.36	GO:1990841	promoter-specific chromatin binding
0.36	GO:0042803	protein homodimerization activity

0.61	GO:0005634	nucleus
0.35	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part
0.33	GO:0005667	transcription factor complex
0.33	GO:0005829	cytosol

tr|T1FZL5|T1FZL5_HELRO
Uncharacterized protein
Search

tr|T1FZL6|T1FZL6_HELRO
Uncharacterized protein
Search

tr|T1FZL7|T1FZL7_HELRO
Uncharacterized protein
Search

TPK1

0.39	Thiamine pyrophosphokinase

0.75	GO:0042357	thiamine diphosphate metabolic process
0.73	GO:0006772	thiamine metabolic process
0.68	GO:0072528	pyrimidine-containing compound biosynthetic process
0.67	GO:0044272	sulfur compound biosynthetic process
0.65	GO:0009108	coenzyme biosynthetic process
0.61	GO:0090407	organophosphate biosynthetic process
0.54	GO:0019438	aromatic compound biosynthetic process
0.48	GO:0016310	phosphorylation
0.38	GO:0006421	asparaginyl-tRNA aminoacylation
0.36	GO:0000413	protein peptidyl-prolyl isomerization

0.81	GO:0004788	thiamine diphosphokinase activity
0.81	GO:0030975	thiamine binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0016301	kinase activity
0.38	GO:0004816	asparagine-tRNA ligase activity
0.36	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.33	GO:0003676	nucleic acid binding

0.33

GO:0005737

cytoplasm

0.81	EC:2.7.6.2	GO:0004788
0.38	KEGG:R03648	GO:0004816

tr|T1FZL8|T1FZL8_HELRO
Uncharacterized protein
Search

PSMD9

0.83	26S proteasome non-ATPase regulatory subunit 9

0.84	GO:0070682	proteasome regulatory particle assembly
0.38	GO:0046676	negative regulation of insulin secretion
0.38	GO:0032024	positive regulation of insulin secretion
0.36	GO:0045893	positive regulation of transcription, DNA-templated
0.35	GO:0097050	type B pancreatic cell apoptotic process
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.35	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway

0.38	GO:0043425	bHLH transcription factor binding
0.37	GO:0003713	transcription coactivator activity
0.34	GO:0008022	protein C-terminus binding
0.33	GO:0004252	serine-type endopeptidase activity

0.61	GO:1905369	endopeptidase complex
0.52	GO:0043234	protein complex
0.41	GO:0005622	intracellular
0.39	GO:0043227	membrane-bounded organelle
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044422	organelle part

0.33

GO:0004252

tr|T1FZL9|T1FZL9_HELRO
Adenylate kinase isoenzyme 6 homolog
Search

AK6

0.71	Adenylate kinase isoenzyme 6

0.69	GO:0046939	nucleotide phosphorylation
0.40	GO:0006364	rRNA processing
0.38	GO:1903506	regulation of nucleic acid-templated transcription
0.38	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.37	GO:0010468	regulation of gene expression
0.37	GO:0006351	transcription, DNA-templated
0.36	GO:0043486	histone exchange
0.36	GO:0034599	cellular response to oxidative stress
0.36	GO:0042274	ribosomal small subunit biogenesis
0.34	GO:2000145	regulation of cell motility

0.78	GO:0004017	adenylate kinase activity
0.58	GO:0016887	ATPase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0009982	pseudouridine synthase activity
0.32	GO:0003723	RNA binding

0.59	GO:0005634	nucleus
0.49	GO:0031974	membrane-enclosed lumen
0.44	GO:0044446	intracellular organelle part
0.37	GO:0005737	cytoplasm
0.36	GO:0035770	ribonucleoprotein granule
0.30	GO:0016020	membrane

0.78

EC:2.7.4.3

GO:0004017

tr|T1FZM0|T1FZM0_HELRO
Uncharacterized protein
Search

0.45	RING finger and CHY zinc finger domain-containing protein 1

0.63

GO:0008270

zinc ion binding

tr|T1FZM1|T1FZM1_HELRO
Uncharacterized protein
Search

NCKIPSD

0.53	NCK interacting protein with SH3 domain

0.70	GO:0010976	positive regulation of neuron projection development
0.49	GO:0006413	translational initiation

0.49	GO:0017022	myosin binding
0.49	GO:0003743	translation initiation factor activity

0.68	GO:0008180	COP9 signalosome
0.30	GO:0016020	membrane

tr|T1FZM2|T1FZM2_HELRO
Uncharacterized protein
Search

0.10	Chloride channel protein

0.77	GO:1902476	chloride transmembrane transport
0.36	GO:0034765	regulation of ion transmembrane transport
0.36	GO:0030321	transepithelial chloride transport
0.34	GO:0030071	regulation of mitotic metaphase/anaphase transition
0.33	GO:0009081	branched-chain amino acid metabolic process
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.32	GO:0006813	potassium ion transport
0.32	GO:0042254	ribosome biogenesis
0.32	GO:0098655	cation transmembrane transport

0.78	GO:0005247	voltage-gated chloride channel activity
0.35	GO:0042802	identical protein binding
0.34	GO:0046872	metal ion binding
0.33	GO:0004084	branched-chain-amino-acid transaminase activity
0.33	GO:0004930	G-protein coupled receptor activity
0.32	GO:0003677	DNA binding
0.32	GO:0008324	cation transmembrane transporter activity

0.39	GO:0030054	cell junction
0.37	GO:0034707	chloride channel complex
0.35	GO:0005886	plasma membrane
0.35	GO:0005794	Golgi apparatus
0.34	GO:0045177	apical part of cell
0.34	GO:0098588	bounding membrane of organelle
0.34	GO:0005680	anaphase-promoting complex
0.34	GO:0031984	organelle subcompartment
0.33	GO:0005829	cytosol

0.33

EC:2.6.1.42

GO:0004084

tr|T1FZM3|T1FZM3_HELRO
Uncharacterized protein
Search

0.45	GO:0006086	acetyl-CoA biosynthetic process from pyruvate
0.41	GO:0006757	ATP generation from ADP
0.40	GO:0016052	carbohydrate catabolic process
0.40	GO:0019362	pyridine nucleotide metabolic process
0.37	GO:0055114	oxidation-reduction process
0.33	GO:0045454	cell redox homeostasis

0.61	GO:0016746	transferase activity, transferring acyl groups
0.44	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity
0.37	GO:0140096	catalytic activity, acting on a protein
0.34	GO:0004148	dihydrolipoyl dehydrogenase activity
0.33	GO:0050660	flavin adenine dinucleotide binding
0.33	GO:0009055	electron transfer activity

0.42	GO:0045254	pyruvate dehydrogenase complex
0.36	GO:0005759	mitochondrial matrix
0.30	GO:0031224	intrinsic component of membrane

0.61

GO:0016746

tr|T1FZM4|T1FZM4_HELRO
Uncharacterized protein
Search

0.76	GO:0016055	Wnt signaling pathway
0.52	GO:0006357	regulation of transcription by RNA polymerase II
0.39	GO:0002681	somatic recombination of T cell receptor gene segments
0.37	GO:0033151	V(D)J recombination
0.37	GO:0048319	axial mesoderm morphogenesis
0.36	GO:2000036	regulation of stem cell population maintenance
0.36	GO:0035019	somatic stem cell population maintenance
0.36	GO:0007351	tripartite regional subdivision
0.36	GO:0000578	embryonic axis specification
0.36	GO:0009948	anterior/posterior axis specification

0.59	GO:0008013	beta-catenin binding
0.55	GO:0003677	DNA binding
0.42	GO:0001067	regulatory region nucleic acid binding
0.37	GO:0016757	transferase activity, transferring glycosyl groups
0.35	GO:0003682	chromatin binding
0.34	GO:0003700	DNA binding transcription factor activity

0.61	GO:0005634	nucleus
0.42	GO:0005829	cytosol
0.42	GO:0005667	transcription factor complex
0.42	GO:0031974	membrane-enclosed lumen
0.39	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

0.37

GO:0016757

tr|T1FZM5|T1FZM5_HELRO
Uncharacterized protein
Search

tr|T1FZM6|T1FZM6_HELRO
Uncharacterized protein
Search

FARS2

0.68	Phenylalanyl-tRNA synthetase alpha chain

0.76	GO:0006432	phenylalanyl-tRNA aminoacylation
0.43	GO:0008033	tRNA processing
0.41	GO:0032259	methylation
0.35	GO:0019464	glycine decarboxylation via glycine cleavage system
0.35	GO:0045454	cell redox homeostasis
0.34	GO:0022904	respiratory electron transport chain

0.76	GO:0004826	phenylalanine-tRNA ligase activity
0.69	GO:0000049	tRNA binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0008168	methyltransferase activity
0.37	GO:0016972	thiol oxidase activity
0.34	GO:0016651	oxidoreductase activity, acting on NAD(P)H
0.33	GO:0005515	protein binding

0.49	GO:0005737	cytoplasm
0.41	GO:0043231	intracellular membrane-bounded organelle
0.35	GO:0031974	membrane-enclosed lumen
0.35	GO:0044446	intracellular organelle part
0.34	GO:1990204	oxidoreductase complex
0.33	GO:0031090	organelle membrane
0.33	GO:0031975	envelope
0.30	GO:0016021	integral component of membrane

0.76

EC:6.1.1.20

GO:0004826

tr|T1FZM7|T1FZM7_HELRO
Uncharacterized protein
Search

CCNK

0.86

Cyclin-K

0.55	GO:1901409	positive regulation of phosphorylation of RNA polymerase II C-terminal domain
0.54	GO:0044828	negative regulation by host of viral genome replication
0.53	GO:2001163	regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
0.52	GO:0071157	negative regulation of cell cycle arrest
0.47	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
0.44	GO:0045944	positive regulation of transcription by RNA polymerase II
0.43	GO:0006974	cellular response to DNA damage stimulus
0.43	GO:0006468	protein phosphorylation
0.37	GO:2000737	negative regulation of stem cell differentiation
0.37	GO:0001701	in utero embryonic development

0.51	GO:0004693	cyclin-dependent protein serine/threonine kinase activity
0.51	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.49	GO:0019901	protein kinase binding
0.46	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.34	GO:0046982	protein heterodimerization activity

0.60	GO:0005634	nucleus
0.55	GO:0002944	cyclin K-CDK12 complex
0.55	GO:0002945	cyclin K-CDK13 complex
0.45	GO:0043233	organelle lumen
0.41	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.51

EC:2.7.11.22

GO:0004693

tr|T1FZM8|T1FZM8_HELRO
Uncharacterized protein
Search

tr|T1FZM9|T1FZM9_HELRO
Uncharacterized protein
Search

0.44	GO:0007409	axonogenesis
0.40	GO:0046426	negative regulation of JAK-STAT cascade
0.40	GO:0097485	neuron projection guidance
0.40	GO:0007166	cell surface receptor signaling pathway
0.39	GO:0006469	negative regulation of protein kinase activity
0.39	GO:0010033	response to organic substance
0.37	GO:0070887	cellular response to chemical stimulus
0.37	GO:0007601	visual perception
0.37	GO:0007186	G-protein coupled receptor signaling pathway
0.36	GO:0021537	telencephalon development

0.41	GO:0005509	calcium ion binding
0.39	GO:0004860	protein kinase inhibitor activity
0.37	GO:0004930	G-protein coupled receptor activity
0.36	GO:0004180	carboxypeptidase activity
0.35	GO:0035374	chondroitin sulfate binding
0.35	GO:0001968	fibronectin binding
0.35	GO:0043236	laminin binding
0.35	GO:0005518	collagen binding
0.34	GO:0008201	heparin binding
0.34	GO:0001653	peptide receptor activity

0.40	GO:0005576	extracellular region
0.34	GO:0046658	anchored component of plasma membrane
0.34	GO:0009986	cell surface
0.34	GO:0005622	intracellular
0.33	GO:0005887	integral component of plasma membrane
0.32	GO:0043233	organelle lumen
0.32	GO:0043234	protein complex
0.32	GO:0043227	membrane-bounded organelle

0.34

GO:0016705

tr|T1FZN0|T1FZN0_HELRO
Uncharacterized protein
Search

tr|T1FZN1|T1FZN1_HELRO
Uncharacterized protein
Search

0.73	N6-adenosine-methyltransferase subunit METTL3

0.78	GO:0080009	mRNA methylation
0.58	GO:1990729	primary miRNA modification
0.55	GO:1903679	positive regulation of cap-independent translational initiation
0.51	GO:0034644	cellular response to UV
0.50	GO:0000398	mRNA splicing, via spliceosome
0.47	GO:0098508	endothelial to hematopoietic transition
0.46	GO:1902036	regulation of hematopoietic stem cell differentiation
0.45	GO:0045746	negative regulation of Notch signaling pathway
0.44	GO:0006974	cellular response to DNA damage stimulus
0.41	GO:0042981	regulation of apoptotic process

0.85	GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
0.49	GO:1904047	S-adenosyl-L-methionine binding
0.48	GO:0003729	mRNA binding
0.47	GO:0046982	protein heterodimerization activity
0.35	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity
0.34	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
0.34	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.60	GO:0005634	nucleus
0.56	GO:0036396	RNA N6-methyladenosine methyltransferase complex
0.46	GO:0031974	membrane-enclosed lumen
0.42	GO:0044446	intracellular organelle part
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.85

EC:2.1.1.62

GO:0016422

tr|T1FZN2|T1FZN2_HELRO
Uncharacterized protein
Search

0.73	Rac small GTPase

0.77	GO:0007264	small GTPase mediated signal transduction
0.41	GO:0010769	regulation of cell morphogenesis involved in differentiation
0.40	GO:0045664	regulation of neuron differentiation
0.40	GO:0120036	plasma membrane bounded cell projection organization
0.40	GO:0030036	actin cytoskeleton organization
0.39	GO:0007394	dorsal closure, elongation of leading edge cells
0.39	GO:0048468	cell development
0.39	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
0.39	GO:0035099	hemocyte migration
0.39	GO:0007426	tracheal outgrowth, open tracheal system

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.38	GO:0048306	calcium-dependent protein binding
0.38	GO:0019901	protein kinase binding
0.35	GO:0051022	Rho GDP-dissociation inhibitor binding
0.34	GO:0051117	ATPase binding
0.34	GO:0042826	histone deacetylase binding
0.34	GO:0004402	histone acetyltransferase activity
0.34	GO:0017137	Rab GTPase binding

0.45	GO:0005622	intracellular
0.38	GO:0036477	somatodendritic compartment
0.38	GO:0030426	growth cone
0.38	GO:0044297	cell body
0.36	GO:0099512	supramolecular fiber
0.36	GO:0012505	endomembrane system
0.35	GO:0044422	organelle part
0.35	GO:0043234	protein complex
0.34	GO:0043228	non-membrane-bounded organelle
0.34	GO:0044309	neuron spine

0.34

GO:0004402

tr|T1FZN3|T1FZN3_HELRO
Uncharacterized protein
Search

MRPS7

0.84	Mitochondrial ribosomal protein S7

0.60	GO:0043043	peptide biosynthetic process
0.55	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.52	GO:0009059	macromolecule biosynthetic process
0.41	GO:0000028	ribosomal small subunit assembly
0.33	GO:0006886	intracellular protein transport

0.44	GO:0003735	structural constituent of ribosome
0.42	GO:0003723	RNA binding
0.32	GO:0016787	hydrolase activity

0.51	GO:0005840	ribosome
0.42	GO:0005759	mitochondrial matrix
0.30	GO:0016020	membrane

0.32

GO:0016787

tr|T1FZN4|T1FZN4_HELRO
Ferrochelatase
Search

FECH

0.54	Ferrochelatase

0.71	GO:0006783	heme biosynthetic process
0.47	GO:0046501	protoporphyrinogen IX metabolic process
0.39	GO:0030218	erythrocyte differentiation
0.38	GO:0061515	myeloid cell development
0.38	GO:0070541	response to platinum ion
0.37	GO:0071695	anatomical structure maturation
0.37	GO:0048469	cell maturation
0.37	GO:0010288	response to lead ion
0.37	GO:0051597	response to methylmercury
0.37	GO:0017085	response to insecticide

0.77	GO:0004325	ferrochelatase activity
0.35	GO:0030350	iron-responsive element binding
0.33	GO:0051537	2 iron, 2 sulfur cluster binding
0.33	GO:0020037	heme binding
0.33	GO:0005506	iron ion binding
0.32	GO:0005524	ATP binding

0.39	GO:0005739	mitochondrion
0.33	GO:0019866	organelle inner membrane
0.30	GO:0031224	intrinsic component of membrane

0.77	EC:4.99.1.1	GO:0004325
0.77	KEGG:R00310	GO:0004325

tr|T1FZN5|T1FZN5_HELRO
Uncharacterized protein
Search

tr|T1FZN6|T1FZN6_HELRO
Uncharacterized protein
Search

RCOR3

0.92	REST corepressor 3

0.46	GO:0000122	negative regulation of transcription by RNA polymerase II
0.38	GO:0070933	histone H4 deacetylation
0.35	GO:1900052	regulation of retinoic acid biosynthetic process
0.34	GO:0006351	transcription, DNA-templated
0.34	GO:0030097	hemopoiesis

0.54	GO:0003677	DNA binding
0.47	GO:0003714	transcription corepressor activity
0.45	GO:0001067	regulatory region nucleic acid binding
0.44	GO:0008134	transcription factor binding
0.40	GO:0003700	DNA binding transcription factor activity
0.37	GO:0019899	enzyme binding

0.60	GO:0005634	nucleus
0.47	GO:0017053	transcriptional repressor complex
0.44	GO:0005667	transcription factor complex
0.36	GO:1990391	DNA repair complex

tr|T1FZN7|T1FZN7_HELRO
Uncharacterized protein
Search

0.51	52 kDa repressor of the inhibitor of the protein kinase

0.56

GO:0016310

phosphorylation

0.68	GO:0046983	protein dimerization activity
0.59	GO:0016301	kinase activity

tr|T1FZN8|T1FZN8_HELRO
Uncharacterized protein
Search

tr|T1FZN9|T1FZN9_HELRO
Uncharacterized protein
Search

tr|T1FZP0|T1FZP0_HELRO
Uncharacterized protein
Search

0.64	Homeobox protein prospero

0.55	GO:0070309	lens fiber cell morphogenesis
0.54	GO:0060836	lymphatic endothelial cell differentiation
0.54	GO:0001946	lymphangiogenesis
0.53	GO:1904252	negative regulation of bile acid metabolic process
0.53	GO:2000979	positive regulation of forebrain neuron differentiation
0.53	GO:0090425	acinar cell differentiation
0.53	GO:0002194	hepatocyte cell migration
0.53	GO:0070365	hepatocyte differentiation
0.53	GO:0060839	endothelial cell fate commitment
0.53	GO:0061114	branching involved in pancreas morphogenesis

0.55	GO:0003677	DNA binding
0.54	GO:0050692	DBD domain binding
0.53	GO:0050693	LBD domain binding
0.52	GO:0016922	ligand-dependent nuclear receptor binding
0.50	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.49	GO:0003714	transcription corepressor activity
0.47	GO:0001067	regulatory region nucleic acid binding
0.46	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding

0.47	GO:0005634	nucleus
0.37	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1FZP1|T1FZP1_HELRO
Uncharacterized protein
Search

0.73	GO:0000122	negative regulation of transcription by RNA polymerase II
0.47	GO:0045010	actin nucleation
0.43	GO:0016192	vesicle-mediated transport

0.58	GO:0003700	DNA binding transcription factor activity
0.45	GO:0003779	actin binding

0.58	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1FZP4|T1FZP4_HELRO
Uncharacterized protein
Search

tr|T1FZP5|T1FZP5_HELRO
Uncharacterized protein
Search

0.95	NK protein (Fragment)

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.36	GO:0007275	multicellular organism development
0.35	GO:0007521	muscle cell fate determination
0.34	GO:0048332	mesoderm morphogenesis
0.34	GO:0001708	cell fate specification
0.34	GO:0048646	anatomical structure formation involved in morphogenesis
0.33	GO:1902679	negative regulation of RNA biosynthetic process

0.65	GO:0043565	sequence-specific DNA binding
0.34	GO:0004000	adenosine deaminase activity
0.33	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.34

EC:3.5.4.4

GO:0004000

tr|T1FZP6|T1FZP6_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.42	GO:0048731	system development
0.39	GO:0007163	establishment or maintenance of cell polarity
0.39	GO:0007605	sensory perception of sound
0.39	GO:0007626	locomotory behavior
0.39	GO:0007186	G-protein coupled receptor signaling pathway
0.39	GO:0016043	cellular component organization
0.39	GO:0048468	cell development
0.38	GO:0030029	actin filament-based process
0.38	GO:0007166	cell surface receptor signaling pathway

0.70	GO:0005509	calcium ion binding
0.39	GO:0004930	G-protein coupled receptor activity

0.56	GO:0005886	plasma membrane
0.43	GO:0098858	actin-based cell projection
0.43	GO:0048471	perinuclear region of cytoplasm
0.42	GO:0005911	cell-cell junction
0.40	GO:0030027	lamellipodium
0.40	GO:0032421	stereocilium bundle
0.39	GO:0043005	neuron projection
0.38	GO:0005634	nucleus
0.35	GO:0044422	organelle part
0.34	GO:0036477	somatodendritic compartment

tr|T1FZP7|T1FZP7_HELRO
Uncharacterized protein
Search

0.66	Transcription initiation factor TFIID subunit

0.66	GO:0006352	DNA-templated transcription, initiation
0.58	GO:0006413	translational initiation
0.50	GO:0070365	hepatocyte differentiation
0.50	GO:2001141	regulation of RNA biosynthetic process
0.50	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.50	GO:0010468	regulation of gene expression
0.48	GO:0035264	multicellular organism growth
0.48	GO:0043966	histone H3 acetylation
0.48	GO:0016578	histone deubiquitination
0.48	GO:0051101	regulation of DNA binding

0.59	GO:0003743	translation initiation factor activity
0.49	GO:0030331	estrogen receptor binding
0.46	GO:0004402	histone acetyltransferase activity
0.46	GO:0003713	transcription coactivator activity
0.46	GO:0070063	RNA polymerase binding
0.43	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
0.38	GO:0003677	DNA binding
0.37	GO:0046982	protein heterodimerization activity
0.34	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity

0.59	GO:0005634	nucleus
0.48	GO:0000428	DNA-directed RNA polymerase complex
0.47	GO:0005667	transcription factor complex
0.46	GO:0048471	perinuclear region of cytoplasm
0.45	GO:0031248	protein acetyltransferase complex
0.45	GO:0031974	membrane-enclosed lumen
0.41	GO:0044446	intracellular organelle part

0.46

GO:0004402

tr|T1FZP8|T1FZP8_HELRO
Uncharacterized protein
Search

0.70	RNA-binding protein orb2

0.72	GO:0006417	regulation of translation
0.44	GO:0007017	microtubule-based process

0.84	GO:0003730	mRNA 3'-UTR binding
0.83	GO:0045182	translation regulator activity
0.43	GO:0003924	GTPase activity
0.42	GO:0032550	purine ribonucleoside binding
0.42	GO:0019001	guanyl nucleotide binding
0.41	GO:0016740	transferase activity
0.38	GO:0032555	purine ribonucleotide binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding

0.45

GO:0005874

microtubule

0.41

GO:0016740

tr|T1FZP9|T1FZP9_HELRO
Uncharacterized protein
Search

0.44	Calmodulin (Fragment)

0.70

GO:0005509

calcium ion binding

tr|T1FZQ0|T1FZQ0_HELRO
Uncharacterized protein
Search

ALKBH8

0.37	Alkylated DNA repair protein alkB like protein 8

0.73	GO:0002098	tRNA wobble uridine modification
0.70	GO:0030488	tRNA methylation
0.51	GO:0055114	oxidation-reduction process
0.41	GO:0006974	cellular response to DNA damage stimulus

0.77	GO:0016300	tRNA (uracil) methyltransferase activity
0.58	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
0.49	GO:0003676	nucleic acid binding
0.45	GO:0008198	ferrous iron binding
0.41	GO:0008270	zinc ion binding
0.37	GO:0030797	24-methylenesterol C-methyltransferase activity
0.34	GO:0030246	carbohydrate binding
0.33	GO:0005515	protein binding

0.45	GO:0016604	nuclear body
0.43	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.77	EC:2.1.1	GO:0016300
0.37	KEGG:R05776	GO:0030797

tr|T1FZQ1|T1FZQ1_HELRO
Uncharacterized protein
Search

tr|T1FZQ2|T1FZQ2_HELRO
Uncharacterized protein
Search

0.76

GO:0010951

negative regulation of endopeptidase activity

0.79

GO:0004867

serine-type endopeptidase inhibitor activity

0.63	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZQ3|T1FZQ3_HELRO
Uncharacterized protein
Search

ARIH2

0.58	RING-type E3 ubiquitin transferase

0.73	GO:0016567	protein ubiquitination
0.52	GO:0071425	hematopoietic stem cell proliferation
0.50	GO:1903955	positive regulation of protein targeting to mitochondrion
0.50	GO:0048588	developmental cell growth
0.48	GO:0006511	ubiquitin-dependent protein catabolic process
0.46	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.33	GO:0055114	oxidation-reduction process

0.73	GO:0004842	ubiquitin-protein transferase activity
0.54	GO:0046872	metal ion binding
0.54	GO:0031624	ubiquitin conjugating enzyme binding
0.48	GO:0016874	ligase activity
0.43	GO:0061659	ubiquitin-like protein ligase activity
0.35	GO:0031418	L-ascorbic acid binding
0.34	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.33	GO:0003676	nucleic acid binding

0.52	GO:0031466	Cul5-RING ubiquitin ligase complex
0.45	GO:0005654	nucleoplasm
0.38	GO:0005737	cytoplasm

0.48	EC:6	GO:0016874
0.73	KEGG:R03876	GO:0004842

tr|T1FZQ4|T1FZQ4_HELRO
Uncharacterized protein
Search

VPS72

0.90	Vacuolar protein sorting-associated protein 72

0.84	GO:0043486	histone exchange
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:0035019	somatic stem cell population maintenance
0.44	GO:0016569	covalent chromatin modification
0.43	GO:0018393	internal peptidyl-lysine acetylation
0.40	GO:0010605	negative regulation of macromolecule metabolic process
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:0006511	ubiquitin-dependent protein catabolic process

0.50	GO:0042393	histone binding
0.43	GO:0004402	histone acetyltransferase activity
0.35	GO:0031625	ubiquitin protein ligase binding
0.35	GO:0003677	DNA binding
0.35	GO:0016651	oxidoreductase activity, acting on NAD(P)H
0.35	GO:0004017	adenylate kinase activity
0.33	GO:0016887	ATPase activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0008144	drug binding

0.61	GO:0005634	nucleus
0.47	GO:0031974	membrane-enclosed lumen
0.44	GO:0043234	protein complex
0.43	GO:0044446	intracellular organelle part
0.42	GO:0031248	protein acetyltransferase complex

0.43

GO:0004402

tr|T1FZQ5|T1FZQ5_HELRO
Uncharacterized protein
Search

0.61	GO:0006508	proteolysis
0.40	GO:0044257	cellular protein catabolic process
0.34	GO:0007034	vacuolar transport
0.34	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.34	GO:0018108	peptidyl-tyrosine phosphorylation
0.34	GO:0010951	negative regulation of endopeptidase activity

0.75	GO:0004185	serine-type carboxypeptidase activity
0.34	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.34	GO:0004867	serine-type endopeptidase inhibitor activity
0.34	GO:0070003	threonine-type peptidase activity
0.33	GO:0004175	endopeptidase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.34	GO:0005839	proteasome core complex
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.75

EC:3.4.16

GO:0004185

tr|T1FZQ6|T1FZQ6_HELRO
Uncharacterized protein
Search

0.40	transmembrane protein 39A-like

0.30

GO:0044425

membrane part

tr|T1FZQ7|T1FZQ7_HELRO
Uncharacterized protein
Search

0.88	N-acylsphingosine amidohydrolase

0.62	GO:0006629	lipid metabolic process
0.56	GO:0048668	collateral sprouting

0.61

GO:0017040

ceramidase activity

0.78	GO:0005764	lysosome
0.47	GO:0005615	extracellular space
0.30	GO:0031224	intrinsic component of membrane

0.61

EC:3.5.1.23

GO:0017040

tr|T1FZQ8|T1FZQ8_HELRO
Uncharacterized protein
Search

DNAL1

0.94	Dynein axonemal light chain 1

0.84

GO:0036158

outer dynein arm assembly

0.85	GO:0045504	dynein heavy chain binding
0.83	GO:0043014	alpha-tubulin binding
0.51	GO:0003774	motor activity

0.54	GO:0030286	dynein complex
0.51	GO:0005874	microtubule
0.49	GO:0042995	cell projection
0.41	GO:0099568	cytoplasmic region
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZQ9|T1FZQ9_HELRO
Uncharacterized protein
Search

tr|T1FZR0|T1FZR0_HELRO
Uncharacterized protein
Search

0.85	Paraplegin

0.61	GO:0006508	proteolysis
0.40	GO:0060013	righting reflex
0.40	GO:0036444	mitochondrial calcium uptake
0.40	GO:0051560	mitochondrial calcium ion homeostasis
0.39	GO:0021675	nerve development
0.39	GO:0048747	muscle fiber development
0.39	GO:0007528	neuromuscular junction development
0.39	GO:0008053	mitochondrial fusion
0.39	GO:0042407	cristae formation
0.39	GO:0040014	regulation of multicellular organism growth

0.70	GO:0004222	metalloendopeptidase activity
0.60	GO:0008270	zinc ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003899	DNA-directed 5'-3' RNA polymerase activity

0.40

GO:0005745

m-AAA complex

0.70

GO:0004222

tr|T1FZR1|T1FZR1_HELRO
Uncharacterized protein
Search

tr|T1FZR2|T1FZR2_HELRO
Uncharacterized protein
Search

0.43	Trifunctional nucleotide phosphoesterase protein YfkN

0.75	GO:0009166	nucleotide catabolic process
0.40	GO:0016311	dephosphorylation
0.33	GO:0043173	nucleotide salvage

0.51	GO:0016787	hydrolase activity
0.51	GO:0000166	nucleotide binding

0.30

GO:0031224

intrinsic component of membrane

0.51

GO:0016787

tr|T1FZR3|T1FZR3_HELRO
Uncharacterized protein
Search

tr|T1FZR4|T1FZR4_HELRO
Uncharacterized protein
Search

0.67	SCP small domain phosphatase

0.68	GO:0016311	dephosphorylation
0.47	GO:0046827	positive regulation of protein export from nucleus
0.46	GO:0030514	negative regulation of BMP signaling pathway
0.41	GO:0036211	protein modification process
0.40	GO:0044267	cellular protein metabolic process
0.34	GO:0043043	peptide biosynthetic process
0.34	GO:0000077	DNA damage checkpoint
0.34	GO:0040012	regulation of locomotion
0.34	GO:0006446	regulation of translational initiation
0.33	GO:0022618	ribonucleoprotein complex assembly

0.69	GO:0016791	phosphatase activity
0.40	GO:0140096	catalytic activity, acting on a protein
0.34	GO:0003743	translation initiation factor activity
0.34	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0003735	structural constituent of ribosome
0.33	GO:0016779	nucleotidyltransferase activity

0.43	GO:0005654	nucleoplasm
0.35	GO:0005852	eukaryotic translation initiation factor 3 complex
0.34	GO:0030896	checkpoint clamp complex
0.34	GO:0016282	eukaryotic 43S preinitiation complex
0.34	GO:0033290	eukaryotic 48S preinitiation complex
0.33	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.69	EC:3.1.3 EC:3.1.3.41	GO:0016791
0.34	KEGG:R05982 KEGG:R06722	GO:0004571

tr|T1FZR5|T1FZR5_HELRO
Uncharacterized protein
Search

0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.73	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.57	GO:0023014	signal transduction by protein phosphorylation
0.55	GO:0035556	intracellular signal transduction
0.49	GO:0055025	positive regulation of cardiac muscle tissue development
0.48	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
0.47	GO:0060485	mesenchyme development
0.47	GO:0061026	cardiac muscle tissue regeneration
0.47	GO:2000366	positive regulation of STAT protein import into nucleus
0.46	GO:0007507	heart development

0.76	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.74	GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.45	GO:0005154	epidermal growth factor receptor binding
0.45	GO:0042802	identical protein binding
0.43	GO:0046983	protein dimerization activity
0.43	GO:0038132	neuregulin binding

0.47	GO:0016323	basolateral plasma membrane
0.46	GO:0043235	receptor complex
0.42	GO:0005622	intracellular
0.41	GO:0016328	lateral plasma membrane
0.40	GO:0016324	apical plasma membrane
0.39	GO:0005615	extracellular space
0.37	GO:0043227	membrane-bounded organelle
0.33	GO:0045211	postsynaptic membrane
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:1990904	ribonucleoprotein complex

0.76	EC:2.7.10.1	GO:0004714
0.34	KEGG:R04545	GO:0046934

tr|T1FZR6|T1FZR6_HELRO
Uncharacterized protein
Search

0.52	GO:0030168	platelet activation
0.40	GO:0050982	detection of mechanical stimulus
0.39	GO:0007155	cell adhesion
0.39	GO:0055114	oxidation-reduction process
0.39	GO:0006898	receptor-mediated endocytosis
0.39	GO:0006508	proteolysis
0.39	GO:0030001	metal ion transport
0.38	GO:0072511	divalent inorganic cation transport
0.38	GO:0098662	inorganic cation transmembrane transport
0.36	GO:0018108	peptidyl-tyrosine phosphorylation

0.52	GO:0070492	oligosaccharide binding
0.47	GO:0005507	copper ion binding
0.42	GO:0005509	calcium ion binding
0.41	GO:0005044	scavenger receptor activity
0.41	GO:0005261	cation channel activity
0.40	GO:0070001	aspartic-type peptidase activity
0.40	GO:0016491	oxidoreductase activity
0.39	GO:0046873	metal ion transmembrane transporter activity
0.39	GO:0005540	hyaluronic acid binding
0.39	GO:0004175	endopeptidase activity

0.43	GO:0005747	mitochondrial respiratory chain complex I
0.38	GO:0005581	collagen trimer
0.30	GO:0031224	intrinsic component of membrane

0.40

GO:0016491

tr|T1FZR7|T1FZR7_HELRO
Uncharacterized protein
Search

0.59	GO:0016226	iron-sulfur cluster assembly
0.56	GO:0007059	chromosome segregation
0.54	GO:0045893	positive regulation of transcription, DNA-templated
0.53	GO:0006281	DNA repair
0.48	GO:0008643	carbohydrate transport
0.46	GO:0055085	transmembrane transport
0.46	GO:0015992	proton transport
0.37	GO:0006351	transcription, DNA-templated

0.63	GO:0030331	estrogen receptor binding
0.57	GO:0003713	transcription coactivator activity
0.53	GO:0005351	sugar:proton symporter activity
0.53	GO:0019899	enzyme binding

0.67	GO:0097361	CIA complex
0.64	GO:0071817	MMXD complex
0.52	GO:0005654	nucleoplasm
0.51	GO:0000139	Golgi membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZR8|T1FZR8_HELRO
Uncharacterized protein
Search

WDR83OS

0.97	WD repeat domain 83 opposite strand

0.37	GO:0008033	tRNA processing
0.34	GO:0006013	mannose metabolic process
0.34	GO:0006915	apoptotic process
0.34	GO:0042981	regulation of apoptotic process
0.33	GO:0006508	proteolysis

0.34	GO:0004559	alpha-mannosidase activity
0.34	GO:0004197	cysteine-type endopeptidase activity
0.34	GO:0030246	carbohydrate binding
0.32	GO:0046872	metal ion binding

0.30

GO:0031224

intrinsic component of membrane

0.34

EC:3.2.1.24

GO:0004559

tr|T1FZR9|T1FZR9_HELRO
Uncharacterized protein
Search

tr|T1FZS0|T1FZS0_HELRO
Uncharacterized protein
Search

tr|T1FZS1|T1FZS1_HELRO
Uncharacterized protein
Search

LYN

0.55	Tyrosine-protein kinase Lyn

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.51	GO:0070667	negative regulation of mast cell proliferation
0.50	GO:0002688	regulation of leukocyte chemotaxis
0.50	GO:2000670	positive regulation of dendritic cell apoptotic process
0.50	GO:0006182	cGMP biosynthetic process
0.50	GO:0002513	tolerance induction to self antigen
0.49	GO:0002431	Fc receptor mediated stimulatory signaling pathway
0.49	GO:0002576	platelet degranulation
0.49	GO:0002774	Fc receptor mediated inhibitory signaling pathway
0.49	GO:0030889	negative regulation of B cell proliferation

0.77	GO:0004713	protein tyrosine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0004383	guanylate cyclase activity
0.48	GO:0140031	phosphorylation-dependent protein binding
0.46	GO:0046875	ephrin receptor binding
0.45	GO:0044325	ion channel binding
0.44	GO:0017124	SH3 domain binding

0.44	GO:0045121	membrane raft
0.44	GO:0048471	perinuclear region of cytoplasm
0.42	GO:0005794	Golgi apparatus
0.40	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.39	GO:0005634	nucleus
0.37	GO:0034666	integrin alpha2-beta1 complex
0.37	GO:0042629	mast cell granule
0.37	GO:0030061	mitochondrial crista
0.36	GO:0014069	postsynaptic density
0.36	GO:0005913	cell-cell adherens junction

0.77

GO:0004713

tr|T1FZS2|T1FZS2_HELRO
Uncharacterized protein
Search

CASK

0.49	Peripheral plasma membrane protein CASK

0.62	GO:0006468	protein phosphorylation
0.39	GO:0018212	peptidyl-tyrosine modification
0.36	GO:0097112	gamma-aminobutyric acid receptor clustering
0.36	GO:1903361	protein localization to basolateral plasma membrane
0.36	GO:0040026	positive regulation of vulval development
0.36	GO:0018991	oviposition
0.35	GO:0009791	post-embryonic development

0.63	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0005159	insulin-like growth factor receptor binding
0.33	GO:0005516	calmodulin binding

0.34	GO:0030054	cell junction
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1FZS3|T1FZS3_HELRO
Uncharacterized protein
Search

0.45	RAS like proto-oncogene A

0.80	GO:0007265	Ras protein signal transduction
0.52	GO:0071360	cellular response to exogenous dsRNA
0.52	GO:2000786	positive regulation of autophagosome assembly
0.50	GO:0032092	positive regulation of protein binding
0.50	GO:0032091	negative regulation of protein binding
0.48	GO:0071902	positive regulation of protein serine/threonine kinase activity
0.48	GO:0009267	cellular response to starvation
0.47	GO:0051665	membrane raft localization
0.47	GO:0017157	regulation of exocytosis
0.46	GO:0051491	positive regulation of filopodium assembly

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.55	GO:0051117	ATPase binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0031625	ubiquitin protein ligase binding
0.48	GO:0031755	Edg-2 lysophosphatidic acid receptor binding
0.45	GO:0017022	myosin binding
0.34	GO:0004713	protein tyrosine kinase activity

0.54	GO:0005886	plasma membrane
0.51	GO:0030496	midbody
0.50	GO:0005776	autophagosome
0.48	GO:0000145	exocyst
0.45	GO:0097610	cell surface furrow
0.44	GO:0032155	cell division site part
0.44	GO:0030139	endocytic vesicle
0.43	GO:0043209	myelin sheath
0.37	GO:0070062	extracellular exosome
0.34	GO:0005925	focal adhesion

0.34

GO:0004713

tr|T1FZS4|T1FZS4_HELRO
Uncharacterized protein
Search

0.67	Lysine-specific demethylase lid

0.51	GO:0032259	methylation
0.48	GO:0034720	histone H3-K4 demethylation
0.46	GO:0036098	male germ-line stem cell population maintenance
0.46	GO:0043970	histone H3-K9 acetylation
0.46	GO:0030717	karyosome formation
0.46	GO:0007526	larval somatic muscle development
0.45	GO:2000737	negative regulation of stem cell differentiation
0.45	GO:0032922	circadian regulation of gene expression
0.45	GO:0045475	locomotor rhythm
0.45	GO:0070193	synaptonemal complex organization

0.54	GO:0046872	metal ion binding
0.53	GO:0003677	DNA binding
0.51	GO:0008168	methyltransferase activity
0.49	GO:0032453	histone demethylase activity (H3-K4 specific)
0.46	GO:0043992	histone acetyltransferase activity (H3-K9 specific)
0.37	GO:0051213	dioxygenase activity
0.36	GO:0050681	androgen receptor binding
0.36	GO:0140034	methylation-dependent protein binding
0.36	GO:0042393	histone binding
0.35	GO:0001067	regulatory region nucleic acid binding

0.61	GO:0005634	nucleus
0.41	GO:0031974	membrane-enclosed lumen
0.41	GO:0000785	chromatin
0.39	GO:1902494	catalytic complex
0.36	GO:0150005	enzyme activator complex
0.34	GO:0032993	protein-DNA complex
0.34	GO:0043234	protein complex
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.51

GO:0008168

tr|T1FZS5|T1FZS5_HELRO
Anion exchange protein
Search

0.64	Anion exchange protein (Fragment)

0.68	GO:0015698	inorganic anion transport
0.68	GO:0098656	anion transmembrane transport
0.43	GO:0007271	synaptic transmission, cholinergic
0.43	GO:0032228	regulation of synaptic transmission, GABAergic
0.42	GO:0015701	bicarbonate transport
0.42	GO:0046685	response to arsenic-containing substance
0.40	GO:0051453	regulation of intracellular pH
0.40	GO:0035725	sodium ion transmembrane transport
0.38	GO:0033326	cerebrospinal fluid secretion
0.37	GO:0003014	renal system process

0.82	GO:0005452	inorganic anion exchanger activity
0.43	GO:0015301	anion:anion antiporter activity
0.43	GO:0008510	sodium:bicarbonate symporter activity
0.41	GO:0015108	chloride transmembrane transporter activity

0.38

GO:0005887

integral component of plasma membrane

tr|T1FZS6|T1FZS6_HELRO
Uncharacterized protein
Search

tr|T1FZS7|T1FZS7_HELRO
Uncharacterized protein
Search

NUDT21

0.73	Cleavage and polyadenylation specificity factor subunit

0.81	GO:0006378	mRNA polyadenylation
0.42	GO:0031439	positive regulation of mRNA cleavage
0.42	GO:1900365	positive regulation of mRNA polyadenylation
0.41	GO:0051290	protein heterotetramerization
0.40	GO:0098789	pre-mRNA cleavage required for polyadenylation
0.38	GO:1901800	positive regulation of proteasomal protein catabolic process
0.36	GO:0030163	protein catabolic process
0.35	GO:0000398	mRNA splicing, via spliceosome
0.35	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.34	GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

0.76	GO:0003729	mRNA binding
0.51	GO:0016787	hydrolase activity
0.40	GO:0017091	AU-rich element binding
0.40	GO:0042826	histone deacetylase binding
0.40	GO:0003682	chromatin binding
0.39	GO:0042802	identical protein binding
0.37	GO:0046983	protein dimerization activity
0.34	GO:0005524	ATP binding
0.34	GO:0043021	ribonucleoprotein complex binding
0.33	GO:0016874	ligase activity

0.81	GO:0005849	mRNA cleavage factor complex
0.41	GO:0042382	paraspeckles
0.39	GO:0005813	centrosome
0.35	GO:0005737	cytoplasm
0.34	GO:0036038	MKS complex
0.34	GO:0030687	preribosome, large subunit precursor
0.34	GO:0005730	nucleolus
0.30	GO:0031224	intrinsic component of membrane

0.51

GO:0016787

tr|T1FZS8|T1FZS8_HELRO
Uncharacterized protein
Search

0.67	GO:0006278	RNA-dependent DNA biosynthetic process
0.44	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.36	GO:0006310	DNA recombination
0.35	GO:0006508	proteolysis
0.35	GO:0045666	positive regulation of neuron differentiation
0.35	GO:0006302	double-strand break repair
0.35	GO:0032196	transposition
0.35	GO:0035023	regulation of Rho protein signal transduction
0.35	GO:0016070	RNA metabolic process
0.34	GO:0043547	positive regulation of GTPase activity

0.67	GO:0003964	RNA-directed DNA polymerase activity
0.45	GO:0004519	endonuclease activity
0.37	GO:0004197	cysteine-type endopeptidase activity
0.36	GO:0004540	ribonuclease activity
0.35	GO:0008270	zinc ion binding
0.35	GO:0005515	protein binding
0.35	GO:0004803	transposase activity
0.35	GO:0003676	nucleic acid binding
0.35	GO:0005096	GTPase activator activity
0.34	GO:0004527	exonuclease activity

0.36	GO:0005581	collagen trimer
0.35	GO:0005634	nucleus
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.67

EC:2.7.7.49

GO:0003964

tr|T1FZS9|T1FZS9_HELRO
Uncharacterized protein
Search

0.49	Thioredoxin domain-containing

0.64	GO:0045454	cell redox homeostasis
0.40	GO:0043277	apoptotic cell clearance
0.40	GO:0034976	response to endoplasmic reticulum stress
0.38	GO:0006457	protein folding
0.35	GO:0035725	sodium ion transmembrane transport
0.35	GO:0007017	microtubule-based process
0.33	GO:0022900	electron transport chain

0.44	GO:0016853	isomerase activity
0.36	GO:0003676	nucleic acid binding
0.36	GO:0140096	catalytic activity, acting on a protein
0.35	GO:0005248	voltage-gated sodium channel activity
0.33	GO:0009055	electron transfer activity

0.39	GO:0012505	endomembrane system
0.37	GO:0043231	intracellular membrane-bounded organelle
0.37	GO:0044444	cytoplasmic part
0.37	GO:0019866	organelle inner membrane
0.36	GO:0005869	dynactin complex
0.35	GO:0001518	voltage-gated sodium channel complex

0.44

GO:0016853

tr|T1FZT0|T1FZT0_HELRO
Uncharacterized protein
Search

0.73	Allergen tropomyosin

0.71	GO:0006936	muscle contraction
0.65	GO:0007015	actin filament organization
0.61	GO:0034609	spicule insertion
0.53	GO:0043393	regulation of protein binding
0.53	GO:0030835	negative regulation of actin filament depolymerization
0.51	GO:0009792	embryo development ending in birth or egg hatching
0.51	GO:0030833	regulation of actin filament polymerization
0.46	GO:0040011	locomotion
0.44	GO:0006260	DNA replication
0.41	GO:0006351	transcription, DNA-templated

0.76	GO:0008307	structural constituent of muscle
0.68	GO:0051015	actin filament binding
0.42	GO:0003700	DNA binding transcription factor activity
0.40	GO:0003677	DNA binding

0.79	GO:0005862	muscle thin filament tropomyosin
0.71	GO:0005884	actin filament
0.42	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZT1|T1FZT1_HELRO
Uncharacterized protein
Search

0.84	Nicotinic acetylcholine receptor subunit type E

0.79	GO:0060079	excitatory postsynaptic potential
0.60	GO:0034220	ion transmembrane transport
0.39	GO:0046662	regulation of oviposition
0.38	GO:1902656	calcium ion import into cytosol
0.38	GO:0007271	synaptic transmission, cholinergic
0.38	GO:0098739	import across plasma membrane
0.38	GO:0006937	regulation of muscle contraction
0.37	GO:0009791	post-embryonic development
0.37	GO:0040012	regulation of locomotion
0.35	GO:0040011	locomotion

0.82	GO:0022848	acetylcholine-gated cation-selective channel activity
0.70	GO:0099600	transmembrane receptor activity
0.33	GO:0003777	microtubule motor activity
0.33	GO:0008017	microtubule binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.78	GO:0045211	postsynaptic membrane
0.73	GO:0030054	cell junction
0.38	GO:0031594	neuromuscular junction
0.30	GO:0016021	integral component of membrane

tr|T1FZT2|T1FZT2_HELRO
Uncharacterized protein
Search

tr|T1FZT3|T1FZT3_HELRO
Uncharacterized protein
Search

AP3S2

0.50	Clathrin adaptor complex small subunit

0.69	GO:0006886	intracellular protein transport
0.69	GO:0016192	vesicle-mediated transport
0.50	GO:0008089	anterograde axonal transport
0.49	GO:0047496	vesicle transport along microtubule
0.48	GO:0097480	establishment of synaptic vesicle localization
0.38	GO:0048072	compound eye pigmentation
0.38	GO:0033060	ocellus pigmentation
0.38	GO:0006726	eye pigment biosynthetic process
0.36	GO:0044550	secondary metabolite biosynthetic process
0.34	GO:0008286	insulin receptor signaling pathway

0.49	GO:0008565	protein transporter activity
0.34	GO:0005515	protein binding
0.33	GO:0003774	motor activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.75	GO:0030117	membrane coat
0.49	GO:1904115	axon cytoplasm
0.39	GO:0030659	cytoplasmic vesicle membrane
0.38	GO:0043231	intracellular membrane-bounded organelle
0.37	GO:0012505	endomembrane system
0.34	GO:0031984	organelle subcompartment
0.34	GO:0016459	myosin complex
0.30	GO:0016021	integral component of membrane

tr|T1FZT4|T1FZT4_HELRO
Uncharacterized protein
Search

0.42	SNF-related serine/threonine-protein kinase

0.63	GO:0006468	protein phosphorylation
0.40	GO:0035556	intracellular signal transduction
0.37	GO:0060217	hemangioblast cell differentiation
0.35	GO:0042981	regulation of apoptotic process
0.34	GO:0030099	myeloid cell differentiation
0.34	GO:1901214	regulation of neuron death
0.34	GO:0006885	regulation of pH
0.34	GO:0043069	negative regulation of programmed cell death
0.34	GO:0035725	sodium ion transmembrane transport
0.33	GO:1902600	hydrogen ion transmembrane transport

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0000287	magnesium ion binding
0.34	GO:0015385	sodium:proton antiporter activity

0.40	GO:0005634	nucleus
0.36	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1FZT5|T1FZT5_HELRO
Uncharacterized protein
Search

PDK2

0.88	Pyruvate dehydrogenase kinase isozyme 4

0.68	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
0.64	GO:0008286	insulin receptor signaling pathway
0.62	GO:0010906	regulation of glucose metabolic process
0.61	GO:0042593	glucose homeostasis
0.60	GO:0006885	regulation of pH
0.59	GO:0031669	cellular response to nutrient levels
0.56	GO:0016310	phosphorylation
0.55	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
0.54	GO:0043255	regulation of carbohydrate biosynthetic process
0.54	GO:0046320	regulation of fatty acid oxidation

0.59	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity
0.50	GO:0042803	protein homodimerization activity
0.45	GO:0032559	adenyl ribonucleotide binding
0.44	GO:0008144	drug binding
0.44	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0032403	protein complex binding
0.34	GO:0046982	protein heterodimerization activity
0.34	GO:0004674	protein serine/threonine kinase activity

0.56	GO:0005967	mitochondrial pyruvate dehydrogenase complex
0.48	GO:0005654	nucleoplasm
0.47	GO:0005829	cytosol
0.43	GO:0031966	mitochondrial membrane
0.43	GO:0019866	organelle inner membrane

0.59

EC:2.7.11.2

GO:0004740

tr|T1FZT6|T1FZT6_HELRO
Polyadenylate-binding protein
Search

0.62	Polyadenylate-binding protein 1-B

0.48	GO:2000623	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.46	GO:0048096	chromatin-mediated maintenance of transcription
0.46	GO:0001556	oocyte maturation
0.46	GO:0045070	positive regulation of viral genome replication
0.45	GO:0051647	nucleus localization
0.45	GO:0006378	mRNA polyadenylation
0.42	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
0.40	GO:0031047	gene silencing by RNA
0.40	GO:0043488	regulation of mRNA stability
0.40	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

0.59	GO:0003723	RNA binding
0.45	GO:0008022	protein C-terminus binding
0.35	GO:0031370	eukaryotic initiation factor 4G binding
0.35	GO:0008494	translation activator activity
0.35	GO:0043621	protein self-association
0.32	GO:0016491	oxidoreductase activity

0.48	GO:0005737	cytoplasm
0.45	GO:0035770	ribonucleoprotein granule
0.44	GO:0071013	catalytic step 2 spliceosome
0.37	GO:0070062	extracellular exosome
0.37	GO:1990124	messenger ribonucleoprotein complex
0.36	GO:0005925	focal adhesion
0.36	GO:0030425	dendrite
0.34	GO:0005844	polysome
0.30	GO:0016020	membrane

0.32

GO:0016491

tr|T1FZT7|T1FZT7_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.38	GO:0060219	camera-type eye photoreceptor cell differentiation
0.35	GO:0034332	adherens junction organization
0.35	GO:0033626	positive regulation of integrin activation by cell surface receptor linked signal transduction
0.35	GO:0002314	germinal center B cell differentiation
0.35	GO:0002315	marginal zone B cell differentiation
0.35	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
0.35	GO:0048536	spleen development
0.35	GO:0007186	G-protein coupled receptor signaling pathway
0.34	GO:0035672	oligopeptide transmembrane transport

0.70	GO:0005509	calcium ion binding
0.35	GO:0005427	proton-dependent oligopeptide secondary active transmembrane transporter activity
0.35	GO:0004930	G-protein coupled receptor activity
0.34	GO:0005178	integrin binding

0.56	GO:0005886	plasma membrane
0.34	GO:0009986	cell surface
0.34	GO:0030054	cell junction
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

tr|T1FZT8|T1FZT8_HELRO
Clathrin light chain
Search

0.52	Clathrin light chain

0.69	GO:0006886	intracellular protein transport
0.69	GO:0016192	vesicle-mediated transport
0.40	GO:0048268	clathrin coat assembly
0.37	GO:0098657	import into cell
0.33	GO:0051301	cell division
0.33	GO:0007049	cell cycle

0.62	GO:0005198	structural molecule activity
0.44	GO:0032050	clathrin heavy chain binding

0.83	GO:0030130	clathrin coat of trans-Golgi network vesicle
0.82	GO:0030132	clathrin coat of coated pit
0.42	GO:0019028	viral capsid
0.41	GO:0071439	clathrin complex
0.36	GO:0099631	postsynaptic endocytic zone cytoplasmic component
0.34	GO:0005819	spindle
0.30	GO:0031224	intrinsic component of membrane

tr|T1FZT9|T1FZT9_HELRO
Uncharacterized protein
Search

0.10	Mitogen-activated protein kinase kinase kinase 7

0.84	GO:0000186	activation of MAPKK activity
0.80	GO:0000165	MAPK cascade
0.65	GO:0007252	I-kappaB phosphorylation
0.63	GO:0043507	positive regulation of JUN kinase activity
0.54	GO:0002726	positive regulation of T cell cytokine production
0.53	GO:0007250	activation of NF-kappaB-inducing kinase activity
0.53	GO:0032743	positive regulation of interleukin-2 production
0.52	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.52	GO:0000187	activation of MAPK activity
0.52	GO:0043966	histone H3 acetylation

0.85	GO:0004709	MAP kinase kinase kinase activity
0.64	GO:0000287	magnesium ion binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.53	GO:0097110	scaffold protein binding
0.47	GO:0042802	identical protein binding
0.36	GO:0004708	MAP kinase kinase activity

0.54	GO:0008385	IkappaB kinase complex
0.52	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
0.44	GO:0005886	plasma membrane
0.36	GO:0014069	postsynaptic density
0.34	GO:0010008	endosome membrane

0.85

EC:2.7.11 EC:2.7.11.25

GO:0004709

tr|T1FZU0|T1FZU0_HELRO
Uncharacterized protein
Search

0.83	Tubulin tyrosine ligase like 8

0.73	GO:0018094	protein polyglycylation
0.49	GO:0060271	cilium assembly
0.41	GO:0030041	actin filament polymerization
0.41	GO:0034314	Arp2/3 complex-mediated actin nucleation
0.38	GO:0001578	microtubule bundle formation
0.35	GO:0003341	cilium movement

0.73	GO:0070735	protein-glycine ligase activity
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding

0.50	GO:0005930	axoneme
0.49	GO:0015630	microtubule cytoskeleton
0.40	GO:0005885	Arp2/3 protein complex
0.37	GO:0099513	polymeric cytoskeletal fiber
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.73

EC:6.3.2

GO:0070735

tr|T1FZU1|T1FZU1_HELRO
Kinesin-like protein
Search

0.74	GO:0007018	microtubule-based movement
0.42	GO:0030705	cytoskeleton-dependent intracellular transport
0.38	GO:0051656	establishment of organelle localization
0.37	GO:0097479	synaptic vesicle localization
0.37	GO:0099003	vesicle-mediated transport in synapse
0.35	GO:0007270	neuron-neuron synaptic transmission
0.35	GO:0021846	cell proliferation in forebrain
0.35	GO:0048917	posterior lateral line ganglion development
0.35	GO:0007274	neuromuscular synaptic transmission
0.34	GO:0051647	nucleus localization

0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0042802	identical protein binding
0.37	GO:0016887	ATPase activity
0.33	GO:0004721	phosphoprotein phosphatase activity
0.33	GO:0046983	protein dimerization activity
0.32	GO:0046872	metal ion binding

0.46	GO:0015630	microtubule cytoskeleton
0.46	GO:0044430	cytoskeletal part
0.45	GO:0099512	supramolecular fiber
0.37	GO:0043234	protein complex
0.37	GO:0045202	synapse
0.36	GO:1904115	axon cytoplasm
0.35	GO:0031410	cytoplasmic vesicle
0.34	GO:0043025	neuronal cell body
0.34	GO:0030425	dendrite
0.34	GO:0012506	vesicle membrane

0.37

GO:0016887

tr|T1FZU2|T1FZU2_HELRO
Uncharacterized protein
Search

0.50	Heparan SulphoTransferase

0.40	GO:0055003	cardiac myofibril assembly
0.39	GO:0045214	sarcomere organization
0.39	GO:0060047	heart contraction
0.38	GO:0015012	heparan sulfate proteoglycan biosynthetic process
0.34	GO:0006477	protein sulfation
0.34	GO:0006024	glycosaminoglycan biosynthetic process
0.33	GO:0060271	cilium assembly
0.33	GO:0006313	transposition, DNA-mediated
0.33	GO:0015074	DNA integration

0.78	GO:0008146	sulfotransferase activity
0.32	GO:0003677	DNA binding
0.31	GO:0016787	hydrolase activity

0.38	GO:0005796	Golgi lumen
0.34	GO:0000139	Golgi membrane
0.33	GO:0005887	integral component of plasma membrane

0.78

EC:2.8.2

GO:0008146

tr|T1FZU3|T1FZU3_HELRO
Uncharacterized protein
Search

0.78	Mitochondrial calcium uptake 1

0.50	GO:0006851	mitochondrial calcium ion transmembrane transport
0.49	GO:0070509	calcium ion import
0.48	GO:0051561	positive regulation of mitochondrial calcium ion concentration
0.47	GO:0060401	cytosolic calcium ion transport
0.43	GO:0051260	protein homooligomerization
0.42	GO:0007615	anesthesia-resistant memory
0.42	GO:0072375	medium-term memory

0.70	GO:0005509	calcium ion binding
0.42	GO:0046982	protein heterodimerization activity
0.42	GO:0042802	identical protein binding

0.48	GO:1990246	uniplex complex
0.45	GO:0005758	mitochondrial intermembrane space
0.44	GO:0032592	integral component of mitochondrial membrane

tr|T1FZU4|T1FZU4_HELRO
E3 ubiquitin-protein ligase
Search

SIAH2

0.56	E3 ubiquitin-protein ligase

0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.72	GO:0016567	protein ubiquitination
0.70	GO:0007275	multicellular organism development
0.51	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
0.51	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.50	GO:0090090	negative regulation of canonical Wnt signaling pathway
0.38	GO:0031396	regulation of protein ubiquitination
0.36	GO:0006915	apoptotic process
0.36	GO:0007049	cell cycle
0.34	GO:0120039	plasma membrane bounded cell projection morphogenesis

0.63	GO:0008270	zinc ion binding
0.50	GO:0016874	ligase activity
0.39	GO:0031624	ubiquitin conjugating enzyme binding
0.36	GO:0004842	ubiquitin-protein transferase activity
0.34	GO:0003714	transcription corepressor activity
0.34	GO:0005272	sodium channel activity
0.33	GO:0003676	nucleic acid binding

0.61	GO:0005634	nucleus
0.44	GO:0005829	cytosol
0.44	GO:0031974	membrane-enclosed lumen
0.40	GO:0044446	intracellular organelle part
0.38	GO:0043025	neuronal cell body
0.38	GO:0005769	early endosome
0.37	GO:0043005	neuron projection
0.30	GO:0031224	intrinsic component of membrane

0.50	EC:6	GO:0016874
0.36	KEGG:R03876	GO:0004842

tr|T1FZU5|T1FZU5_HELRO
Uncharacterized protein
Search

0.33

GO:0055114

oxidation-reduction process

0.36	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
0.35	GO:0008270	zinc ion binding
0.34	GO:0016887	ATPase activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0016740	transferase activity

0.30

GO:0031224

intrinsic component of membrane

0.36

EC:1.2.4

GO:0016624

tr|T1FZU6|T1FZU6_HELRO
Uncharacterized protein
Search

USO1

0.91	USO1 vesicle transport factor

0.85	GO:0048280	vesicle fusion with Golgi apparatus
0.69	GO:0006886	intracellular protein transport
0.54	GO:0007030	Golgi organization
0.52	GO:0048211	Golgi vesicle docking
0.52	GO:0045056	transcytosis
0.48	GO:0006888	ER to Golgi vesicle-mediated transport

0.67	GO:0008565	protein transporter activity
0.56	GO:0045296	cadherin binding

0.74	GO:0000139	Golgi membrane
0.57	GO:0001650	fibrillar center
0.52	GO:0048471	perinuclear region of cytoplasm
0.48	GO:0012507	ER to Golgi transport vesicle membrane
0.48	GO:0005795	Golgi stack
0.47	GO:0005829	cytosol
0.45	GO:0005783	endoplasmic reticulum
0.36	GO:0070382	exocytic vesicle
0.30	GO:0016021	integral component of membrane

tr|T1FZU7|T1FZU7_HELRO
Uncharacterized protein
Search

0.62	Methyltransferase like 4

0.59	GO:0032259	methylation
0.43	GO:0006305	DNA alkylation
0.43	GO:0044728	DNA methylation or demethylation

0.59	GO:0008168	methyltransferase activity
0.48	GO:0003676	nucleic acid binding
0.40	GO:0140097	catalytic activity, acting on DNA

0.39	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.59

GO:0008168

tr|T1FZU8|T1FZU8_HELRO
Uncharacterized protein
Search

PRELID3B

0.96	PRELI domain containing 3

0.45

GO:0015914

phospholipid transport

0.48

GO:1990050

phosphatidic acid transporter activity

0.79

GO:0005758

mitochondrial intermembrane space

tr|T1FZU9|T1FZU9_HELRO
Uncharacterized protein
Search

0.78	GO:0007281	germ cell development
0.41	GO:0045727	positive regulation of translation
0.40	GO:0006446	regulation of translational initiation
0.39	GO:0070935	3'-UTR-mediated mRNA stabilization
0.37	GO:0051321	meiotic cell cycle
0.36	GO:0032447	protein urmylation
0.35	GO:0034227	tRNA thio-modification
0.35	GO:0002098	tRNA wobble uridine modification

0.74	GO:0003729	mRNA binding
0.44	GO:0008494	translation activator activity
0.34	GO:0000049	tRNA binding
0.34	GO:0016779	nucleotidyltransferase activity

0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.34

EC:2.7.7

GO:0016779

tr|T1FZV0|T1FZV0_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.45	GO:0007166	cell surface receptor signaling pathway
0.44	GO:0060429	epithelium development
0.43	GO:0022405	hair cycle process
0.43	GO:0007186	G-protein coupled receptor signaling pathway
0.43	GO:0008544	epidermis development
0.43	GO:0043588	skin development
0.43	GO:0007267	cell-cell signaling
0.42	GO:0030154	cell differentiation
0.42	GO:1902910	positive regulation of melanosome transport

0.70	GO:0005509	calcium ion binding
0.43	GO:0004930	G-protein coupled receptor activity
0.37	GO:0042802	identical protein binding
0.36	GO:0046983	protein dimerization activity
0.33	GO:0004867	serine-type endopeptidase inhibitor activity

0.56	GO:0005886	plasma membrane
0.39	GO:0045177	apical part of cell
0.38	GO:0005913	cell-cell adherens junction
0.38	GO:0005902	microvillus
0.36	GO:0005654	nucleoplasm
0.34	GO:0045202	synapse
0.33	GO:0005783	endoplasmic reticulum
0.33	GO:0032391	photoreceptor connecting cilium
0.30	GO:0016021	integral component of membrane

tr|T1FZV1|T1FZV1_HELRO
Uncharacterized protein
Search

tr|T1FZV2|T1FZV2_HELRO
Uncharacterized protein
Search

0.43	Dynein heavy chain

0.74	GO:0007018	microtubule-based movement
0.56	GO:0036159	inner dynein arm assembly
0.41	GO:0071910	determination of liver left/right asymmetry
0.39	GO:0001539	cilium or flagellum-dependent cell motility
0.35	GO:0006508	proteolysis
0.33	GO:0016567	protein ubiquitination

0.75	GO:0003777	microtubule motor activity
0.53	GO:0005509	calcium ion binding
0.52	GO:0045503	dynein light chain binding
0.52	GO:0030554	adenyl nucleotide binding
0.52	GO:0051959	dynein light intermediate chain binding
0.52	GO:0045505	dynein intermediate chain binding
0.51	GO:0032555	purine ribonucleotide binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0016887	ATPase activity

0.79	GO:0030286	dynein complex
0.57	GO:0044447	axoneme part
0.43	GO:0005829	cytosol
0.36	GO:0005874	microtubule
0.30	GO:0031224	intrinsic component of membrane

0.46

GO:0016887

tr|T1FZV3|T1FZV3_HELRO
Uncharacterized protein
Search

0.45	Matrix metalloproteinase-9

0.61	GO:0006508	proteolysis
0.52	GO:0006954	inflammatory response
0.49	GO:0060022	hard palate development
0.37	GO:0097186	amelogenesis
0.37	GO:0022617	extracellular matrix disassembly
0.36	GO:0006955	immune response
0.35	GO:0030163	protein catabolic process
0.34	GO:0002446	neutrophil mediated immunity
0.34	GO:0043299	leukocyte degranulation
0.34	GO:0042119	neutrophil activation

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.37	GO:0016758	transferase activity, transferring hexosyl groups
0.34	GO:0016504	peptidase activator activity
0.34	GO:0004252	serine-type endopeptidase activity
0.32	GO:0003676	nucleic acid binding

0.74	GO:0031012	extracellular matrix
0.38	GO:0005886	plasma membrane
0.38	GO:0005789	endoplasmic reticulum membrane
0.35	GO:0031225	anchored component of membrane
0.35	GO:0035579	specific granule membrane
0.34	GO:0009986	cell surface
0.30	GO:0016021	integral component of membrane

0.70

GO:0004222

tr|T1FZV4|T1FZV4_HELRO
Proteasome endopeptidase complex
Search

PSMA3

0.49	Proteasome endopeptidase complex

0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.44	GO:0052548	regulation of endopeptidase activity
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.35	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:1902036	regulation of hematopoietic stem cell differentiation
0.35	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
0.35	GO:0070498	interleukin-1-mediated signaling pathway

0.77	GO:0070003	threonine-type peptidase activity
0.65	GO:0004175	endopeptidase activity
0.34	GO:0005515	protein binding
0.33	GO:0004930	G-protein coupled receptor activity
0.33	GO:0016758	transferase activity, transferring hexosyl groups
0.32	GO:0003677	DNA binding

0.79	GO:0019773	proteasome core complex, alpha-subunit complex
0.61	GO:0005634	nucleus
0.49	GO:0005737	cytoplasm
0.38	GO:0045202	synapse
0.36	GO:0070062	extracellular exosome
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

0.33

GO:0016758

tr|T1FZV5|T1FZV5_HELRO
Uncharacterized protein
Search

tr|T1FZV6|T1FZV6_HELRO
Uncharacterized protein
Search

0.67	Nascent polypeptide-associated complex subunit alpha

0.40	GO:0015031	protein transport
0.39	GO:0051083	'de novo' cotranslational protein folding
0.37	GO:0072599	establishment of protein localization to endoplasmic reticulum
0.37	GO:0090150	establishment of protein localization to membrane
0.36	GO:0046907	intracellular transport

0.39	GO:0070300	phosphatidic acid binding
0.39	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding
0.38	GO:0070273	phosphatidylinositol-4-phosphate binding
0.38	GO:0032266	phosphatidylinositol-3-phosphate binding
0.38	GO:0005515	protein binding

0.84	GO:0005854	nascent polypeptide-associated complex
0.39	GO:0042788	polysomal ribosome

tr|T1FZV7|T1FZV7_HELRO
Uncharacterized protein
Search

0.72	Inhibitor of trypsin and hageman factor

0.79	GO:0009611	response to wounding
0.76	GO:0010951	negative regulation of endopeptidase activity
0.35	GO:0006508	proteolysis

0.79	GO:0004867	serine-type endopeptidase inhibitor activity
0.35	GO:0008233	peptidase activity

0.35	GO:0005576	extracellular region
0.30	GO:0044425	membrane part

0.35

GO:0008233

tr|T1FZV8|T1FZV8_HELRO
Uncharacterized protein
Search

tr|T1FZV9|T1FZV9_HELRO
Uncharacterized protein
Search

REL

0.75	Embryonic polarity protein dorsal

0.63	GO:0007249	I-kappaB kinase/NF-kappaB signaling
0.58	GO:0048518	positive regulation of biological process
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.50	GO:0032688	negative regulation of interferon-beta production
0.48	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
0.48	GO:0044093	positive regulation of molecular function
0.47	GO:0006366	transcription by RNA polymerase II
0.46	GO:0045087	innate immune response

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.49	GO:0001067	regulatory region nucleic acid binding
0.44	GO:0070379	high mobility group box 1 binding
0.43	GO:0003682	chromatin binding
0.41	GO:0070491	repressing transcription factor binding
0.39	GO:0042802	identical protein binding
0.36	GO:0046982	protein heterodimerization activity

0.61	GO:0005634	nucleus
0.55	GO:0071159	NF-kappaB complex
0.49	GO:0005737	cytoplasm
0.47	GO:0033256	I-kappaB/NF-kappaB complex
0.42	GO:0061174	type I terminal bouton
0.41	GO:0031594	neuromuscular junction
0.36	GO:0005667	transcription factor complex
0.34	GO:0070013	intracellular organelle lumen
0.33	GO:0044446	intracellular organelle part

tr|T1FZW0|T1FZW0_HELRO
Uncharacterized protein
Search

ZNF330

0.37	Zinc finger protein 330

0.38

GO:0035167

larval lymph gland hemopoiesis

0.63	GO:0008270	zinc ion binding
0.33	GO:0005515	protein binding
0.33	GO:0016874	ligase activity
0.32	GO:0003677	DNA binding

0.61	GO:0005634	nucleus
0.49	GO:0030496	midbody
0.47	GO:0000775	chromosome, centromeric region
0.44	GO:0031974	membrane-enclosed lumen
0.30	GO:0044425	membrane part

0.33

GO:0016874

tr|T1FZW1|T1FZW1_HELRO
General transcription factor IIH subunit 4
Search

GTF2H4

0.84	General transcription factor IIH subunit 4

0.73	GO:0006289	nucleotide-excision repair
0.70	GO:0032392	DNA geometric change
0.57	GO:0006351	transcription, DNA-templated
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.45	GO:0006468	protein phosphorylation
0.43	GO:0010224	response to UV-B
0.42	GO:0032781	positive regulation of ATPase activity
0.37	GO:0006438	valyl-tRNA aminoacylation

0.72	GO:0004003	ATP-dependent DNA helicase activity
0.55	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.44	GO:0003690	double-stranded DNA binding
0.42	GO:0001671	ATPase activator activity
0.41	GO:0140110	transcription regulator activity
0.38	GO:0004832	valine-tRNA ligase activity
0.37	GO:0002161	aminoacyl-tRNA editing activity
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0032555	purine ribonucleotide binding
0.34	GO:0008144	drug binding

0.81	GO:0000439	core TFIIH complex
0.56	GO:0005675	holo TFIIH complex
0.50	GO:0016607	nuclear speck
0.49	GO:0005669	transcription factor TFIID complex
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.55	EC:2.7.11.23	GO:0008353
0.38	KEGG:R03665	GO:0004832

tr|T1FZW2|T1FZW2_HELRO
Uncharacterized protein
Search

DEF8

0.96	Differentially expressed in FDCP 8

0.62	GO:0035556	intracellular signal transduction
0.42	GO:1900029	positive regulation of ruffle assembly
0.42	GO:0046852	positive regulation of bone remodeling
0.42	GO:0045124	regulation of bone resorption
0.41	GO:0032418	lysosome localization
0.41	GO:0032846	positive regulation of homeostatic process
0.36	GO:0007017	microtubule-based process
0.36	GO:0007010	cytoskeleton organization
0.34	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.34	GO:0007186	G-protein coupled receptor signaling pathway

0.50	GO:0046872	metal ion binding
0.37	GO:0005200	structural constituent of cytoskeleton
0.35	GO:0003924	GTPase activity
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0019001	guanyl nucleotide binding
0.35	GO:0004980	melanocyte-stimulating hormone receptor activity
0.35	GO:0004527	exonuclease activity
0.34	GO:0032555	purine ribonucleotide binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0004222	metalloendopeptidase activity

0.45	GO:0005622	intracellular
0.36	GO:0099512	supramolecular fiber
0.34	GO:0043228	non-membrane-bounded organelle
0.34	GO:0044422	organelle part
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0004222

tr|T1FZW3|T1FZW3_HELRO
Uncharacterized protein
Search

0.60	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

0.42	GO:0006506	GPI anchor biosynthetic process
0.35	GO:0043486	histone exchange
0.35	GO:0055085	transmembrane transport
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression

0.45	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity
0.35	GO:0005215	transporter activity

0.35	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.45

EC:2.4.1.198

GO:0017176

tr|T1FZW4|T1FZW4_HELRO
Uncharacterized protein
Search

0.57	GO:0045892	negative regulation of transcription, DNA-templated
0.40	GO:0035186	syncytial blastoderm mitotic cell cycle
0.38	GO:0007411	axon guidance
0.38	GO:0045814	negative regulation of gene expression, epigenetic
0.37	GO:0016458	gene silencing
0.37	GO:0006338	chromatin remodeling
0.34	GO:0055114	oxidation-reduction process

0.47	GO:0046872	metal ion binding
0.39	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.37	GO:0003682	chromatin binding
0.36	GO:0003677	DNA binding

0.68	GO:0035102	PRC1 complex
0.39	GO:0005704	polytene chromosome band
0.30	GO:0031224	intrinsic component of membrane

0.39

EC:1.3.1.74

GO:0032440

tr|T1FZW5|T1FZW5_HELRO
Uncharacterized protein
Search

0.30	Nudix (Nucleoside diphosphate linked moiety X)-type motif 16

0.51

GO:0016787

hydrolase activity

0.51

GO:0016787

tr|T1FZW6|T1FZW6_HELRO
Uncharacterized protein
Search

0.58	Putative guanine nucleotide exchange factor for rho and rac gtpase (Fragment)

0.78	GO:0035023	regulation of Rho protein signal transduction
0.66	GO:0065009	regulation of molecular function
0.57	GO:0006468	protein phosphorylation
0.47	GO:0045599	negative regulation of fat cell differentiation
0.44	GO:0035556	intracellular signal transduction
0.35	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway
0.34	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0043065	positive regulation of apoptotic process

0.78	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.60	GO:0004674	protein serine/threonine kinase activity
0.48	GO:0032559	adenyl ribonucleotide binding
0.47	GO:0008144	drug binding
0.47	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003676	nucleic acid binding

0.37	GO:0005622	intracellular
0.34	GO:0099512	supramolecular fiber
0.33	GO:0043228	non-membrane-bounded organelle
0.33	GO:0044422	organelle part
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.60

GO:0004674

tr|T1FZW7|T1FZW7_HELRO
Uncharacterized protein
Search

NLE1

0.93	Notchless protein like protein 1

0.53	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
0.53	GO:0001826	inner cell mass cell differentiation
0.53	GO:0061484	hematopoietic stem cell homeostasis
0.53	GO:0007219	Notch signaling pathway
0.51	GO:0042273	ribosomal large subunit biogenesis
0.51	GO:0001756	somitogenesis
0.50	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.50	GO:0048705	skeletal system morphogenesis
0.49	GO:0001822	kidney development
0.48	GO:0045930	negative regulation of mitotic cell cycle

0.36	GO:0051018	protein kinase A binding
0.34	GO:0004402	histone acetyltransferase activity
0.33	GO:0003743	translation initiation factor activity
0.33	GO:0016757	transferase activity, transferring glycosyl groups
0.33	GO:0016301	kinase activity

0.71	GO:0005730	nucleolus
0.41	GO:0005840	ribosome

0.34

GO:0004402

tr|T1FZW8|T1FZW8_HELRO
5-formyltetrahydrofolate cyclo-ligase
Search

MTHFS

0.42	5-formyltetrahydrofolate cyclo-ligase

0.39	GO:0006511	ubiquitin-dependent protein catabolic process
0.39	GO:0035999	tetrahydrofolate interconversion
0.38	GO:0009396	folic acid-containing compound biosynthetic process
0.36	GO:0046657	folic acid catabolic process
0.34	GO:0006536	glutamate metabolic process
0.33	GO:0015942	formate metabolic process
0.33	GO:0008616	queuosine biosynthetic process
0.33	GO:0034470	ncRNA processing
0.32	GO:0006399	tRNA metabolic process
0.32	GO:0009408	response to heat

0.77	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0046872	metal ion binding
0.39	GO:0070003	threonine-type peptidase activity
0.37	GO:0004175	endopeptidase activity
0.34	GO:0072341	modified amino acid binding
0.34	GO:0031406	carboxylic acid binding
0.34	GO:0033218	amide binding

0.40	GO:0019773	proteasome core complex, alpha-subunit complex
0.37	GO:0043231	intracellular membrane-bounded organelle
0.35	GO:0005737	cytoplasm
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.77	EC:6.3.3.2	GO:0030272
0.77	KEGG:R02301	GO:0030272

tr|T1FZW9|T1FZW9_HELRO
Uncharacterized protein
Search

SDCBP

0.94	Putative pdz domain containing protein found in a variety of eumetazoan signaling molecules

0.77	GO:0007268	chemical synaptic transmission
0.73	GO:0030036	actin cytoskeleton organization
0.62	GO:0035556	intracellular signal transduction
0.50	GO:0030307	positive regulation of cell growth
0.49	GO:0030335	positive regulation of cell migration
0.48	GO:0008284	positive regulation of cell proliferation
0.38	GO:1903553	positive regulation of extracellular exosome assembly
0.38	GO:0002091	negative regulation of receptor internalization
0.38	GO:1903543	positive regulation of exosomal secretion
0.38	GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus

0.53	GO:0005137	interleukin-5 receptor binding
0.41	GO:0045545	syndecan binding
0.38	GO:0050839	cell adhesion molecule binding
0.38	GO:0005109	frizzled binding
0.38	GO:0042043	neurexin family protein binding
0.38	GO:0046875	ephrin receptor binding
0.37	GO:0047485	protein N-terminus binding
0.37	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.37	GO:0008022	protein C-terminus binding
0.37	GO:0019838	growth factor binding

0.54	GO:0005895	interleukin-5 receptor complex
0.49	GO:0031965	nuclear membrane
0.45	GO:0005654	nucleoplasm
0.45	GO:0005829	cytosol
0.37	GO:0042470	melanosome
0.37	GO:0005925	focal adhesion
0.37	GO:0070062	extracellular exosome
0.37	GO:0045121	membrane raft
0.36	GO:0072562	blood microparticle
0.36	GO:0005789	endoplasmic reticulum membrane

tr|T1FZX0|T1FZX0_HELRO
Uncharacterized protein
Search

0.10	Sushi, nidogen and EGF-like domains 1 (Fragment)

0.66	GO:0007219	Notch signaling pathway
0.62	GO:0007275	multicellular organism development
0.52	GO:0097150	neuronal stem cell population maintenance
0.52	GO:0002085	inhibition of neuroepithelial cell differentiation
0.51	GO:0060847	endothelial cell fate specification
0.51	GO:0014807	regulation of somitogenesis
0.51	GO:0046331	lateral inhibition
0.51	GO:0048633	positive regulation of skeletal muscle tissue growth
0.51	GO:0045747	positive regulation of Notch signaling pathway
0.51	GO:0045605	negative regulation of epidermal cell differentiation

0.70	GO:0005509	calcium ion binding
0.57	GO:0005112	Notch binding
0.51	GO:0030957	Tat protein binding
0.49	GO:0097110	scaffold protein binding
0.38	GO:0003682	chromatin binding
0.38	GO:0004872	receptor activity
0.36	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.36	GO:0098772	molecular function regulator
0.35	GO:0001047	core promoter binding
0.35	GO:0004871	signal transducer activity

0.48	GO:0005912	adherens junction
0.48	GO:0016324	apical plasma membrane
0.47	GO:0098857	membrane microdomain
0.46	GO:0031410	cytoplasmic vesicle
0.39	GO:0035003	subapical complex
0.38	GO:0009986	cell surface
0.37	GO:0005764	lysosome
0.37	GO:0005576	extracellular region
0.37	GO:0012505	endomembrane system
0.36	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex

0.34

EC:3.1.1.4

GO:0004623

tr|T1FZX1|T1FZX1_HELRO
Uncharacterized protein
Search

PPP3R1

0.93	Calcineurin B regulatory subunit

0.46	GO:0051531	NFAT protein import into nucleus
0.45	GO:0033173	calcineurin-NFAT signaling cascade
0.44	GO:0060487	lung epithelial cell differentiation
0.44	GO:0001569	branching involved in blood vessel morphogenesis
0.44	GO:0022011	myelination in peripheral nervous system
0.44	GO:0001837	epithelial to mesenchymal transition
0.42	GO:0007507	heart development
0.41	GO:0006470	protein dephosphorylation
0.39	GO:0006529	asparagine biosynthetic process
0.38	GO:0045944	positive regulation of transcription by RNA polymerase II

0.70	GO:0005509	calcium ion binding
0.42	GO:0016018	cyclosporin A binding
0.41	GO:0004721	phosphoprotein phosphatase activity
0.39	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity
0.39	GO:0019904	protein domain specific binding
0.38	GO:0043130	ubiquitin binding
0.35	GO:0019899	enzyme binding
0.34	GO:0005516	calmodulin binding

0.43	GO:0042383	sarcolemma
0.41	GO:0005955	calcineurin complex
0.36	GO:0005829	cytosol
0.33	GO:0005654	nucleoplasm
0.33	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.41

GO:0004721

tr|T1FZX2|T1FZX2_HELRO
Serine/threonine-protein kinase PLK
Search

PLK1

0.70	Serine/threonine-protein kinase polo

0.63	GO:0006468	protein phosphorylation
0.57	GO:0051081	nuclear envelope disassembly
0.57	GO:0072425	signal transduction involved in G2 DNA damage checkpoint
0.56	GO:0070194	synaptonemal complex disassembly
0.56	GO:0071168	protein localization to chromatin
0.56	GO:0090435	protein localization to nuclear envelope
0.56	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
0.55	GO:0016321	female meiosis chromosome segregation
0.55	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
0.55	GO:1901673	regulation of mitotic spindle assembly

0.65	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.53	GO:0010997	anaphase-promoting complex binding
0.51	GO:0019901	protein kinase binding
0.50	GO:0008017	microtubule binding
0.49	GO:0042802	identical protein binding
0.45	GO:0000287	magnesium ion binding

0.54	GO:0051233	spindle midzone
0.54	GO:0030496	midbody
0.53	GO:0000795	synaptonemal complex
0.53	GO:0005876	spindle microtubule
0.53	GO:0000942	condensed nuclear chromosome outer kinetochore
0.52	GO:0005815	microtubule organizing center
0.52	GO:0000922	spindle pole
0.48	GO:0000785	chromatin
0.35	GO:0005737	cytoplasm
0.34	GO:0005654	nucleoplasm

0.65

GO:0004674

tr|T1FZX3|T1FZX3_HELRO
Uncharacterized protein
Search

WDR66

0.78	WD repeat-containing protein 66

0.87	GO:0002574	thrombocyte differentiation
0.87	GO:0030223	neutrophil differentiation

tr|T1FZX5|T1FZX5_HELRO
Uncharacterized protein
Search

0.71	Candidate serotonin receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.54	GO:0007210	serotonin receptor signaling pathway
0.46	GO:0007615	anesthesia-resistant memory
0.46	GO:0002121	inter-male aggressive behavior
0.45	GO:0050795	regulation of behavior
0.45	GO:0008049	male courtship behavior
0.44	GO:0042752	regulation of circadian rhythm
0.42	GO:0051239	regulation of multicellular organismal process
0.41	GO:0095500	acetylcholine receptor signaling pathway
0.37	GO:0097746	regulation of blood vessel diameter

0.72	GO:0004930	G-protein coupled receptor activity
0.54	GO:0099589	serotonin receptor activity
0.52	GO:0030594	neurotransmitter receptor activity
0.37	GO:0051378	serotonin binding
0.33	GO:0004222	metalloendopeptidase activity
0.32	GO:0005178	integrin binding
0.32	GO:0001664	G-protein coupled receptor binding
0.32	GO:0003677	DNA binding

0.44	GO:0005887	integral component of plasma membrane
0.32	GO:0005634	nucleus

0.33

GO:0004222

tr|T1FZX6|T1FZX6_HELRO
Uncharacterized protein
Search

0.39	Voltage and ligand gated potassium channel

0.73	GO:0071805	potassium ion transmembrane transport
0.72	GO:0034765	regulation of ion transmembrane transport
0.41	GO:0007605	sensory perception of sound
0.39	GO:0007018	microtubule-based movement
0.39	GO:0042391	regulation of membrane potential
0.38	GO:0044837	actomyosin contractile ring organization
0.38	GO:0000912	assembly of actomyosin apparatus involved in cytokinesis
0.38	GO:0099518	vesicle cytoskeletal trafficking
0.35	GO:0046662	regulation of oviposition
0.34	GO:0007617	mating behavior

0.78	GO:0005249	voltage-gated potassium channel activity
0.40	GO:0005230	extracellular ligand-gated ion channel activity
0.40	GO:0003777	microtubule motor activity
0.40	GO:0008017	microtubule binding
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0000155	phosphorelay sensor kinase activity
0.34	GO:0003779	actin binding
0.33	GO:0003755	peptidyl-prolyl cis-trans isomerase activity

0.37	GO:0005887	integral component of plasma membrane
0.34	GO:0016459	myosin complex
0.34	GO:0034705	potassium channel complex

0.34

EC:2.7.3

GO:0000155

tr|T1FZX7|T1FZX7_HELRO
Uncharacterized protein
Search

tr|T1FZX8|T1FZX8_HELRO
Uncharacterized protein
Search

0.50	Alpha-globin transcription factor CP2

0.70	GO:0006366	transcription by RNA polymerase II
0.70	GO:0045944	positive regulation of transcription by RNA polymerase II
0.64	GO:0009299	mRNA transcription
0.36	GO:0001525	angiogenesis
0.34	GO:0016310	phosphorylation

0.76	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.59	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.55	GO:0008134	transcription factor binding
0.43	GO:0008022	protein C-terminus binding
0.34	GO:0016301	kinase activity

0.54	GO:0005654	nucleoplasm
0.53	GO:0005829	cytosol
0.47	GO:0043234	protein complex
0.30	GO:0016020	membrane

tr|T1FZX9|T1FZX9_HELRO
Uncharacterized protein
Search

CANT1

0.84	Soluble calcium-activated nucleotidase 1

0.52	GO:0030166	proteoglycan biosynthetic process
0.39	GO:0009191	ribonucleoside diphosphate catabolic process
0.39	GO:0009140	pyrimidine nucleoside diphosphate catabolic process
0.39	GO:0046048	UDP metabolic process
0.39	GO:0009222	pyrimidine ribonucleotide catabolic process
0.38	GO:0009137	purine nucleoside diphosphate catabolic process
0.38	GO:0060465	pharynx development
0.38	GO:0040009	regulation of growth rate
0.38	GO:1901069	guanosine-containing compound catabolic process
0.37	GO:0008340	determination of adult lifespan

0.84	GO:0017110	nucleoside-diphosphatase activity
0.70	GO:0005509	calcium ion binding
0.45	GO:0042803	protein homodimerization activity
0.35	GO:0016491	oxidoreductase activity
0.34	GO:0003677	DNA binding
0.34	GO:0005044	scavenger receptor activity
0.33	GO:0004871	signal transducer activity

0.36	GO:0005789	endoplasmic reticulum membrane
0.36	GO:0032580	Golgi cisterna membrane
0.35	GO:1904724	tertiary granule lumen
0.35	GO:0035580	specific granule lumen
0.35	GO:1904813	ficolin-1-rich granule lumen
0.34	GO:0070062	extracellular exosome
0.33	GO:0005634	nucleus
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.84

EC:3.6.1.6

GO:0017110

tr|T1FZY0|T1FZY0_HELRO
Uncharacterized protein
Search

0.40	Leishmanolysin peptidase

0.72	GO:0007155	cell adhesion
0.61	GO:0006508	proteolysis
0.39	GO:1902769	regulation of choline O-acetyltransferase activity
0.38	GO:0007100	mitotic centrosome separation
0.38	GO:0008354	germ cell migration
0.38	GO:0045842	positive regulation of mitotic metaphase/anaphase transition
0.37	GO:0051298	centrosome duplication
0.37	GO:0019915	lipid storage
0.37	GO:0007052	mitotic spindle organization
0.37	GO:0007444	imaginal disc development

0.70	GO:0004222	metalloendopeptidase activity
0.35	GO:0004082	bisphosphoglycerate mutase activity
0.34	GO:0004619	phosphoglycerate mutase activity
0.34	GO:0030276	clathrin binding
0.33	GO:0005543	phospholipid binding
0.33	GO:0046872	metal ion binding
0.32	GO:0003677	DNA binding

0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.70

GO:0004222

tr|T1FZY2|T1FZY2_HELRO
Palmitoyltransferase
Search

ZDHHC7

0.51	Palmitoyltransferase

0.43	GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
0.42	GO:0018345	protein palmitoylation
0.42	GO:0046854	phosphatidylinositol phosphorylation
0.34	GO:0006508	proteolysis

0.79	GO:0019706	protein-cysteine S-palmitoyltransferase activity
0.35	GO:0004252	serine-type endopeptidase activity

0.39	GO:0005794	Golgi apparatus
0.34	GO:0042765	GPI-anchor transamidase complex
0.33	GO:0005774	vacuolar membrane

0.79

EC:2.3.1.225

GO:0019706

tr|T1FZY3|T1FZY3_HELRO
Uncharacterized protein
Search

0.66	Solute carrier family 18 (Vesicular monoamine), member 2 (Fragment)

0.66	GO:0042493	response to drug
0.63	GO:0007626	locomotory behavior
0.62	GO:0014075	response to amine
0.58	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle
0.57	GO:0006837	serotonin transport
0.57	GO:0009791	post-embryonic development
0.56	GO:0009410	response to xenobiotic stimulus
0.55	GO:0055085	transmembrane transport
0.51	GO:0009636	response to toxic substance

0.64	GO:0015238	drug transmembrane transporter activity
0.58	GO:0015222	serotonin transmembrane transporter activity

0.52	GO:0098793	presynapse
0.46	GO:0005887	integral component of plasma membrane

tr|T1FZY4|T1FZY4_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.49	GO:0048057	R3/R4 development
0.47	GO:0007186	G-protein coupled receptor signaling pathway
0.47	GO:0007166	cell surface receptor signaling pathway
0.47	GO:0070593	dendrite self-avoidance
0.47	GO:0016318	ommatidial rotation
0.47	GO:1902669	positive regulation of axon guidance
0.46	GO:0007424	open tracheal system development
0.46	GO:0007367	segment polarity determination
0.46	GO:0016319	mushroom body development

0.70	GO:0005509	calcium ion binding
0.48	GO:0004930	G-protein coupled receptor activity
0.43	GO:0005057	signal transducer activity, downstream of receptor
0.37	GO:0050839	cell adhesion molecule binding
0.35	GO:0032403	protein complex binding
0.34	GO:0008233	peptidase activity
0.33	GO:0004867	serine-type endopeptidase inhibitor activity

0.56	GO:0005886	plasma membrane
0.43	GO:0030054	cell junction
0.37	GO:0098858	actin-based cell projection
0.37	GO:0031254	cell trailing edge
0.37	GO:0045178	basal part of cell
0.35	GO:0005615	extracellular space
0.34	GO:0032421	stereocilium bundle
0.34	GO:0043005	neuron projection
0.32	GO:0044422	organelle part
0.30	GO:0016021	integral component of membrane

0.34

GO:0008233

tr|T1FZY5|T1FZY5_HELRO
Uncharacterized protein
Search

tr|T1FZY6|T1FZY6_HELRO
Uncharacterized protein
Search

0.74	GO:0007018	microtubule-based movement
0.53	GO:0007270	neuron-neuron synaptic transmission
0.52	GO:0051654	establishment of mitochondrion localization
0.52	GO:0007274	neuromuscular synaptic transmission
0.50	GO:0030705	cytoskeleton-dependent intracellular transport
0.39	GO:0048917	posterior lateral line ganglion development
0.39	GO:1904647	response to rotenone
0.39	GO:0048918	posterior lateral line nerve development
0.38	GO:1990535	neuron projection maintenance
0.38	GO:0030225	macrophage differentiation

0.74	GO:0003777	microtubule motor activity
0.70	GO:0008017	microtubule binding
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0016887	ATPase activity
0.38	GO:0097110	scaffold protein binding
0.36	GO:0019900	kinase binding
0.35	GO:0019894	kinesin binding
0.34	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity

0.52	GO:1904115	axon cytoplasm
0.48	GO:0005875	microtubule associated complex
0.48	GO:0030659	cytoplasmic vesicle membrane
0.42	GO:0005739	mitochondrion
0.36	GO:0005874	microtubule
0.30	GO:0031224	intrinsic component of membrane

0.42

GO:0016887

tr|T1FZY7|T1FZY7_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.47	GO:0007399	nervous system development
0.45	GO:0048513	animal organ development
0.44	GO:0003002	regionalization
0.43	GO:0009653	anatomical structure morphogenesis
0.43	GO:0060429	epithelium development
0.43	GO:0007498	mesoderm development
0.43	GO:0009790	embryo development
0.42	GO:0060322	head development
0.41	GO:0120036	plasma membrane bounded cell projection organization

0.70	GO:0005509	calcium ion binding
0.40	GO:0004930	G-protein coupled receptor activity
0.37	GO:0045296	cadherin binding
0.33	GO:0004835	tubulin-tyrosine ligase activity
0.32	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0003723	RNA binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0008144	drug binding

0.55	GO:0005886	plasma membrane
0.41	GO:0043005	neuron projection
0.41	GO:0032421	stereocilium bundle
0.40	GO:0098858	actin-based cell projection
0.37	GO:0044291	cell-cell contact zone
0.36	GO:0030427	site of polarized growth
0.36	GO:0120038	plasma membrane bounded cell projection part
0.36	GO:0044422	organelle part
0.32	GO:0005783	endoplasmic reticulum
0.32	GO:0048471	perinuclear region of cytoplasm

0.33

EC:6.3.2.25

GO:0004835

tr|T1FZY8|T1FZY8_HELRO
Uncharacterized protein
Search

0.34	Lactadherin (Fragment)

0.30

GO:0044425

membrane part

tr|T1FZY9|T1FZY9_HELRO
Uncharacterized protein
Search

0.67	Sjogren syndrome antigen B

0.63	GO:0006396	RNA processing
0.45	GO:0071045	nuclear histone mRNA catabolic process
0.44	GO:1903608	protein localization to cytoplasmic stress granule
0.43	GO:0075522	IRES-dependent viral translational initiation
0.43	GO:0071431	tRNA-containing ribonucleoprotein complex export from nucleus
0.43	GO:0051031	tRNA transport
0.42	GO:0097064	ncRNA export from nucleus
0.37	GO:0006399	tRNA metabolic process

0.59	GO:0003723	RNA binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0003677	DNA binding

0.61	GO:0005634	nucleus
0.61	GO:0030529	intracellular ribonucleoprotein complex
0.41	GO:0000791	euchromatin
0.35	GO:0005737	cytoplasm
0.33	GO:0019013	viral nucleocapsid

tr|T1FZZ0|T1FZZ0_HELRO
Uncharacterized protein
Search

tr|T1FZZ1|T1FZZ1_HELRO
Uncharacterized protein
Search

0.53	GO:0055114	oxidation-reduction process
0.33	GO:0007608	sensory perception of smell
0.33	GO:0035023	regulation of Rho protein signal transduction
0.32	GO:0065009	regulation of molecular function
0.32	GO:0071897	DNA biosynthetic process
0.32	GO:0006260	DNA replication

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.67	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.35	GO:0003958	NADPH-hemoprotein reductase activity
0.34	GO:0010181	FMN binding
0.33	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.32	GO:0003887	DNA-directed DNA polymerase activity
0.32	GO:0003677	DNA binding

0.34	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0031090	organelle membrane
0.30	GO:0031224	intrinsic component of membrane

0.68

GO:0016705

tr|T1FZZ2|T1FZZ2_HELRO
Uncharacterized protein
Search

DPYD

0.88	Suppressor-of-rudimentary dihydropyrimidine dehydrogenase mutant

0.86	GO:0019483	beta-alanine biosynthetic process
0.58	GO:0006206	pyrimidine nucleobase metabolic process
0.57	GO:0006214	thymidine catabolic process
0.53	GO:0055114	oxidation-reduction process
0.52	GO:0046112	nucleobase biosynthetic process
0.50	GO:0072528	pyrimidine-containing compound biosynthetic process
0.50	GO:0046113	nucleobase catabolic process
0.48	GO:0072523	purine-containing compound catabolic process
0.47	GO:0006144	purine nucleobase metabolic process
0.47	GO:0042737	drug catabolic process

0.85	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity
0.66	GO:0051539	4 iron, 4 sulfur cluster binding
0.56	GO:0004152	dihydroorotate dehydrogenase activity
0.48	GO:0042803	protein homodimerization activity
0.36	GO:0050661	NADP binding
0.35	GO:0002058	uracil binding
0.35	GO:0046872	metal ion binding
0.35	GO:0050660	flavin adenine dinucleotide binding
0.35	GO:0004159	dihydrouracil dehydrogenase (NAD+) activity
0.33	GO:0010181	FMN binding

0.49	GO:0005737	cytoplasm
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.85	EC:1.3.1.2	GO:0017113
0.56	KEGG:R01868	GO:0004152

tr|T1FZZ3|T1FZZ3_HELRO
Uncharacterized protein
Search

DNAH7

0.88	Dynein axonemal heavy chain 7

0.74	GO:0007018	microtubule-based movement
0.57	GO:0036159	inner dynein arm assembly
0.44	GO:0071910	determination of liver left/right asymmetry
0.44	GO:0006072	glycerol-3-phosphate metabolic process
0.43	GO:0007605	sensory perception of sound
0.37	GO:0055114	oxidation-reduction process
0.36	GO:0006508	proteolysis
0.35	GO:0060285	cilium-dependent cell motility
0.34	GO:0061817	endoplasmic reticulum-plasma membrane tethering
0.33	GO:0006869	lipid transport

0.75	GO:0003777	microtubule motor activity
0.59	GO:0005509	calcium ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0045503	dynein light chain binding
0.51	GO:0051959	dynein light intermediate chain binding
0.50	GO:0045505	dynein intermediate chain binding
0.45	GO:0004368	glycerol-3-phosphate dehydrogenase activity
0.45	GO:0016887	ATPase activity

0.78	GO:0030286	dynein complex
0.55	GO:0044447	axoneme part
0.46	GO:0005829	cytosol
0.44	GO:0009331	glycerol-3-phosphate dehydrogenase complex
0.35	GO:0005874	microtubule
0.30	GO:0016021	integral component of membrane

0.45

EC:1.1.5.3

GO:0004368

tr|T1FZZ4|T1FZZ4_HELRO
Uncharacterized protein
Search

SEC24A

0.69	SEC24 homolog B, COPII coat complex component

0.78	GO:0006888	ER to Golgi vesicle-mediated transport
0.69	GO:0006886	intracellular protein transport
0.50	GO:0035459	cargo loading into vesicle
0.49	GO:0051668	localization within membrane
0.48	GO:0048194	Golgi vesicle budding
0.46	GO:2000189	positive regulation of cholesterol homeostasis
0.46	GO:0045714	regulation of low-density lipoprotein particle receptor biosynthetic process
0.43	GO:0050714	positive regulation of protein secretion
0.37	GO:1901301	regulation of cargo loading into COPII-coated vesicle
0.37	GO:0021747	cochlear nucleus development

0.63	GO:0008270	zinc ion binding
0.34	GO:0004831	tyrosine-tRNA ligase activity
0.33	GO:0005515	protein binding
0.32	GO:0003723	RNA binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.80	GO:0030127	COPII vesicle coat
0.45	GO:0000139	Golgi membrane
0.35	GO:0005829	cytosol
0.33	GO:0005789	endoplasmic reticulum membrane

0.34	EC:6.1.1.1	GO:0004831
0.34	KEGG:R02918	GO:0004831

tr|T1FZZ5|T1FZZ5_HELRO
Uncharacterized protein
Search

0.80	Putative HAT, C-terminal dimerization domain-containing protein

0.68

GO:0046983

protein dimerization activity

tr|T1FZZ6|T1FZZ6_HELRO
Uncharacterized protein
Search

0.58	GO:0006855	drug transmembrane transport
0.46	GO:0015844	monoamine transport
0.44	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle
0.43	GO:0015696	ammonium transport
0.43	GO:0015850	organic hydroxy compound transport
0.41	GO:0042417	dopamine metabolic process
0.41	GO:0007631	feeding behavior
0.38	GO:1901374	acetate ester transport
0.37	GO:1904647	response to rotenone
0.37	GO:1904340	positive regulation of dopaminergic neuron differentiation

0.58	GO:0015238	drug transmembrane transporter activity
0.46	GO:0008504	monoamine transmembrane transporter activity
0.43	GO:0005326	neurotransmitter transporter activity
0.43	GO:0008519	ammonium transmembrane transporter activity
0.42	GO:1901618	organic hydroxy compound transmembrane transporter activity
0.38	GO:1901375	acetate ester transmembrane transporter activity
0.38	GO:0042166	acetylcholine binding
0.37	GO:0015101	organic cation transmembrane transporter activity
0.34	GO:0005549	odorant binding
0.34	GO:0004984	olfactory receptor activity

0.43	GO:0098793	presynapse
0.42	GO:0030133	transport vesicle
0.41	GO:0099503	secretory vesicle
0.39	GO:0005887	integral component of plasma membrane
0.37	GO:0030122	AP-2 adaptor complex
0.36	GO:0030660	Golgi-associated vesicle membrane
0.36	GO:0031594	neuromuscular junction
0.36	GO:0044431	Golgi apparatus part

0.32

GO:0016746

tr|T1FZZ7|T1FZZ7_HELRO
Polypeptide N-acetylgalactosaminyltransferase
Search

0.65	Polypeptide N-acetylgalactosaminyltransferase

0.73	GO:0043413	macromolecule glycosylation
0.73	GO:0009101	glycoprotein biosynthetic process
0.59	GO:0006464	cellular protein modification process
0.43	GO:0032504	multicellular organism reproduction

0.69	GO:0030246	carbohydrate binding
0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.34	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0046872	metal ion binding

0.72	GO:0000139	Golgi membrane
0.43	GO:0031985	Golgi cisterna
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.65

GO:0016757

tr|T1FZZ8|T1FZZ8_HELRO
Uncharacterized protein
Search

tr|T1FZZ9|T1FZZ9_HELRO
Uncharacterized protein
Search

0.73	JNK-interacting protein 3-like

0.58	GO:0007257	activation of JUN kinase activity
0.55	GO:0016192	vesicle-mediated transport
0.51	GO:0030421	defecation
0.50	GO:0018991	oviposition
0.48	GO:0097480	establishment of synaptic vesicle localization
0.43	GO:0046907	intracellular transport
0.43	GO:0040011	locomotion

0.67	GO:0030159	receptor signaling complex scaffold activity
0.63	GO:0005078	MAP-kinase scaffold activity
0.61	GO:0019894	kinesin binding
0.59	GO:0008432	JUN kinase binding
0.48	GO:0016301	kinase activity

0.51	GO:0043194	axon initial segment
0.47	GO:0043025	neuronal cell body
0.45	GO:0045202	synapse
0.41	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1G000|T1G000_HELRO
Uncharacterized protein
Search

0.56	Cytoplasmic tyrosine-protein kinase BMX (Fragment)

0.77

GO:0018108

peptidyl-tyrosine phosphorylation

0.81	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.81

GO:0004715

tr|T1G001|T1G001_HELRO
Uncharacterized protein
Search

0.54	Mitochondrial cytochrome c oxidase subunit IV

0.63	GO:1902600	hydrogen ion transmembrane transport
0.61	GO:0022900	electron transport chain
0.41	GO:0007406	negative regulation of neuroblast proliferation
0.40	GO:0007030	Golgi organization
0.40	GO:0008283	cell proliferation
0.39	GO:0000278	mitotic cell cycle
0.35	GO:0006508	proteolysis
0.34	GO:0006119	oxidative phosphorylation
0.34	GO:0009060	aerobic respiration
0.33	GO:0006564	L-serine biosynthetic process

0.65	GO:0015002	heme-copper terminal oxidase activity
0.65	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.62	GO:0009055	electron transfer activity
0.36	GO:0004252	serine-type endopeptidase activity
0.33	GO:0004648	O-phospho-L-serine:2-oxoglutarate aminotransferase activity
0.33	GO:0016874	ligase activity

0.37	GO:0005739	mitochondrion
0.36	GO:0045277	respiratory chain complex IV
0.34	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.65

EC:1.9.3

GO:0016676

tr|T1G002|T1G002_HELRO
Uncharacterized protein
Search

NAA20

0.30	N-terminal acetyltransferase B complex catalytic subunit

0.48	GO:0017196	N-terminal peptidyl-methionine acetylation
0.40	GO:0043524	negative regulation of neuron apoptotic process
0.40	GO:0016573	histone acetylation
0.34	GO:0000001	mitochondrion inheritance
0.34	GO:0030433	ubiquitin-dependent ERAD pathway
0.33	GO:0046177	D-gluconate catabolic process
0.33	GO:0032956	regulation of actin cytoskeleton organization
0.32	GO:0016310	phosphorylation

0.68	GO:0008080	N-acetyltransferase activity
0.33	GO:0046316	gluconokinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.51	GO:0031416	NatB complex
0.43	GO:0005829	cytosol
0.42	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.68	EC:2.3.1	GO:0008080
0.33	KEGG:R01737	GO:0046316

tr|T1G003|T1G003_HELRO
Uncharacterized protein
Search

0.69	GO:0006633	fatty acid biosynthetic process
0.46	GO:0071329	cellular response to sucrose stimulus
0.43	GO:0019432	triglyceride biosynthetic process
0.42	GO:0005977	glycogen metabolic process
0.41	GO:0000902	cell morphogenesis
0.40	GO:0031999	negative regulation of fatty acid beta-oxidation
0.40	GO:0051289	protein homotetramerization
0.40	GO:0097009	energy homeostasis
0.40	GO:0010884	positive regulation of lipid storage
0.39	GO:0060421	positive regulation of heart growth

0.76	GO:0004075	biotin carboxylase activity
0.75	GO:0003989	acetyl-CoA carboxylase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0046872	metal ion binding
0.38	GO:0042802	identical protein binding
0.33	GO:0046983	protein dimerization activity

0.36	GO:0005634	nucleus
0.36	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.76

EC:6.3.4.14

GO:0004075

tr|T1G004|T1G004_HELRO
Uncharacterized protein
Search

0.61	Putative Gtp-binding protein parf partner of arf

0.35	GO:0006480	N-terminal protein amino acid methylation
0.35	GO:0006614	SRP-dependent cotranslational protein targeting to membrane

0.65	GO:0003924	GTPase activity
0.64	GO:0032550	purine ribonucleoside binding
0.64	GO:0019001	guanyl nucleotide binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0008312	7S RNA binding
0.34	GO:0046872	metal ion binding
0.33	GO:0008168	methyltransferase activity

0.38	GO:0005813	centrosome
0.37	GO:0005829	cytosol
0.35	GO:0005634	nucleus
0.35	GO:0048500	signal recognition particle
0.30	GO:0016020	membrane

0.33

GO:0008168

tr|T1G005|T1G005_HELRO
Uncharacterized protein
Search

0.76	StAR related lipid transfer domain containing 5

0.86	GO:0032052	bile acid binding
0.72	GO:0008289	lipid binding

tr|T1G006|T1G006_HELRO
Uncharacterized protein
Search

TMED2

0.84	Transmembrane emp24 domain trafficking protein 2

0.51	GO:0032525	somite rostral/caudal axis specification
0.50	GO:0036342	post-anal tail morphogenesis
0.50	GO:0034260	negative regulation of GTPase activity
0.49	GO:0001947	heart looping
0.49	GO:0001843	neural tube closure
0.49	GO:0035264	multicellular organism growth
0.48	GO:0072659	protein localization to plasma membrane
0.48	GO:0007030	Golgi organization
0.47	GO:0060716	labyrinthine layer blood vessel development
0.47	GO:0001893	maternal placenta development

0.34	GO:0004386	helicase activity
0.34	GO:0005515	protein binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008168	methyltransferase activity
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0008144	drug binding
0.33	GO:0003676	nucleic acid binding

0.49	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.44	GO:0005794	Golgi apparatus
0.44	GO:0005783	endoplasmic reticulum
0.40	GO:0042589	zymogen granule membrane
0.40	GO:0030137	COPI-coated vesicle
0.37	GO:0030660	Golgi-associated vesicle membrane
0.37	GO:0030662	coated vesicle membrane
0.37	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0031984	organelle subcompartment
0.34	GO:0030134	COPII-coated ER to Golgi transport vesicle

0.33

GO:0008168

tr|T1G007|T1G007_HELRO
Uncharacterized protein
Search

tr|T1G008|T1G008_HELRO
Uncharacterized protein
Search

DTD2

0.77	D-tyrosyl-tRNA deacylase 2

0.73	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity
0.44	GO:0015914	phospholipid transport

0.80	GO:0051499	D-aminoacyl-tRNA deacylase activity
0.44	GO:0005548	phospholipid transporter activity

0.49

GO:0005737

cytoplasm

tr|T1G009|T1G009_HELRO
Uncharacterized protein
Search

0.59	GO:0016567	protein ubiquitination
0.54	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.47	GO:0048149	behavioral response to ethanol
0.47	GO:0007616	long-term memory
0.43	GO:0008584	male gonad development
0.39	GO:0007286	spermatid development
0.36	GO:0001578	microtubule bundle formation
0.35	GO:0000910	cytokinesis

0.60	GO:0004842	ubiquitin-protein transferase activity
0.53	GO:0061659	ubiquitin-like protein ligase activity
0.50	GO:0016874	ligase activity
0.38	GO:0001871	pattern binding
0.37	GO:0030246	carbohydrate binding
0.37	GO:0005515	protein binding
0.36	GO:0008270	zinc ion binding
0.34	GO:0003723	RNA binding

0.53	GO:0005654	nucleoplasm
0.43	GO:0036126	sperm flagellum
0.35	GO:0005856	cytoskeleton
0.30	GO:0031224	intrinsic component of membrane

0.50	EC:6	GO:0016874
0.60	KEGG:R03876	GO:0004842

tr|T1G010|T1G010_HELRO
Uncharacterized protein
Search

0.55	Glucose-dependent insulinotropic receptor

0.35	GO:0070647	protein modification by small protein conjugation or removal
0.34	GO:0042073	intraciliary transport
0.33	GO:0006508	proteolysis
0.33	GO:0060271	cilium assembly
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:0006313	transposition, DNA-mediated
0.33	GO:0015074	DNA integration
0.32	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.32	GO:0007186	G-protein coupled receptor signaling pathway
0.32	GO:0006355	regulation of transcription, DNA-templated

0.35	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.34	GO:0004842	ubiquitin-protein transferase activity
0.33	GO:0031683	G-protein beta/gamma-subunit complex binding
0.33	GO:0043565	sequence-specific DNA binding
0.33	GO:0015631	tubulin binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0003700	DNA binding transcription factor activity
0.33	GO:0004636	phosphoribosyl-ATP diphosphatase activity
0.32	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor
0.32	GO:0017076	purine nucleotide binding

0.34	GO:0030992	intraciliary transport particle B
0.33	GO:0031514	motile cilium
0.33	GO:0043231	intracellular membrane-bounded organelle
0.32	GO:0044444	cytoplasmic part
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.33	EC:3.6.1.31	GO:0004636
0.34	KEGG:R03876	GO:0004842

tr|T1G011|T1G011_HELRO
Uncharacterized protein
Search

ARMC7

0.63	Armadillo repeat-containing protein 7

0.41	GO:0060052	neurofilament cytoskeleton organization
0.41	GO:0007100	mitotic centrosome separation
0.40	GO:2000574	regulation of microtubule motor activity
0.38	GO:0007399	nervous system development
0.38	GO:0006281	DNA repair
0.37	GO:0006783	heme biosynthetic process
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression

0.77	GO:0045294	alpha-catenin binding
0.73	GO:0019903	protein phosphatase binding
0.71	GO:0045296	cadherin binding
0.38	GO:0004325	ferrochelatase activity
0.36	GO:0003676	nucleic acid binding

0.76	GO:0016342	catenin complex
0.59	GO:0005634	nucleus
0.47	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.38	EC:4.99.1.1	GO:0004325
0.38	KEGG:R00310	GO:0004325

tr|T1G012|T1G012_HELRO
Uncharacterized protein
Search

GPN1

0.90	XPA binding protein 1, GTPase

0.51	GO:1990022	RNA polymerase III complex localization to nucleus
0.51	GO:0044376	RNA polymerase II complex import to nucleus
0.39	GO:0007064	mitotic sister chromatid cohesion
0.38	GO:0006606	protein import into nucleus

0.68	GO:0003924	GTPase activity
0.35	GO:0016887	ATPase activity
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0019001	guanyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding

0.46	GO:0005654	nucleoplasm
0.45	GO:0005829	cytosol
0.42	GO:0005739	mitochondrion
0.37	GO:0055029	nuclear DNA-directed RNA polymerase complex

0.35

GO:0016887

tr|T1G013|T1G013_HELRO
Uncharacterized protein
Search

0.51	Zinc finger MYM-type protein 1

0.68	GO:0046983	protein dimerization activity
0.38	GO:0008270	zinc ion binding

tr|T1G014|T1G014_HELRO
Uncharacterized protein
Search

RAB34

0.91	RAB34, member RAS oncogene family b

0.39	GO:0090385	phagosome-lysosome fusion
0.37	GO:0032418	lysosome localization
0.37	GO:0043001	Golgi to plasma membrane protein transport
0.37	GO:1905171	positive regulation of protein localization to phagocytic vesicle
0.36	GO:0044351	macropinocytosis
0.36	GO:1900426	positive regulation of defense response to bacterium
0.36	GO:0019882	antigen processing and presentation
0.36	GO:0007041	lysosomal transport
0.34	GO:0071333	cellular response to glucose stimulus
0.34	GO:0050714	positive regulation of protein secretion

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032553	ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0030742	GTP-dependent protein binding
0.37	GO:0017160	Ral GTPase binding
0.34	GO:0003958	NADPH-hemoprotein reductase activity
0.34	GO:0004623	phospholipase A2 activity
0.33	GO:0050661	NADP binding

0.39	GO:0045202	synapse
0.38	GO:0030670	phagocytic vesicle membrane
0.37	GO:0001726	ruffle
0.36	GO:0031985	Golgi cisterna
0.36	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0031256	leading edge membrane
0.35	GO:0031253	cell projection membrane
0.35	GO:0070062	extracellular exosome
0.35	GO:0005770	late endosome
0.35	GO:0005769	early endosome

0.34

EC:1.6.2.4

GO:0003958

tr|T1G015|T1G015_HELRO
Uncharacterized protein
Search

0.25	AMPdependent synthetase and ligase

0.46	GO:0001676	long-chain fatty acid metabolic process
0.43	GO:0008218	bioluminescence
0.33	GO:0046677	response to antibiotic
0.33	GO:0055114	oxidation-reduction process

0.52	GO:0016874	ligase activity
0.35	GO:0004497	monooxygenase activity
0.34	GO:0051087	chaperone binding
0.33	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0008144	drug binding
0.33	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.32	GO:0046872	metal ion binding

0.34	GO:0042579	microbody
0.30	GO:0031224	intrinsic component of membrane

0.52

GO:0016874

tr|T1G016|T1G016_HELRO
Uncharacterized protein
Search

tr|T1G017|T1G017_HELRO
Uncharacterized protein
Search

PGAM5

0.71	Serine/threonine-protein phosphatase Pgam5, mitochondrial

0.78	GO:0090141	positive regulation of mitochondrial fission
0.56	GO:0035970	peptidyl-threonine dephosphorylation
0.55	GO:0072347	response to anesthetic
0.52	GO:0071902	positive regulation of protein serine/threonine kinase activity
0.50	GO:0009408	response to heat
0.36	GO:0019319	hexose biosynthetic process
0.36	GO:0006006	glucose metabolic process
0.36	GO:0006757	ATP generation from ADP
0.35	GO:0006090	pyruvate metabolic process
0.35	GO:0016052	carbohydrate catabolic process

0.54	GO:0043539	protein serine/threonine kinase activator activity
0.52	GO:0004721	phosphoprotein phosphatase activity
0.51	GO:0019900	kinase binding
0.37	GO:0046538	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity

0.51	GO:0005741	mitochondrial outer membrane
0.30	GO:0016021	integral component of membrane

0.52

GO:0004721

tr|T1G018|T1G018_HELRO
Mannosyltransferase
Search

ALG12

0.58	Mannosyltransferase

0.47	GO:0006488	dolichol-linked oligosaccharide biosynthetic process
0.43	GO:0006487	protein N-linked glycosylation
0.43	GO:0097502	mannosylation
0.34	GO:0006438	valyl-tRNA aminoacylation
0.34	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity
0.34	GO:0019236	response to pheromone
0.33	GO:0006457	protein folding
0.33	GO:0007186	G-protein coupled receptor signaling pathway

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.34	GO:0004832	valine-tRNA ligase activity
0.34	GO:0002161	aminoacyl-tRNA editing activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.72	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.65	EC:2.4	GO:0016757
0.34	KEGG:R03665	GO:0004832

tr|T1G019|T1G019_HELRO
Uncharacterized protein
Search

0.72	Putative 52 kDa repressor of the inhibitor of the protein kinase (Fragment)

0.57

GO:0016310

phosphorylation

0.66	GO:0046983	protein dimerization activity
0.60	GO:0016301	kinase activity

tr|T1G020|T1G020_HELRO
Uncharacterized protein
Search

tr|T1G021|T1G021_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.44	GO:0048731	system development
0.42	GO:0007267	cell-cell signaling
0.41	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
0.40	GO:0090176	microtubule cytoskeleton organization involved in establishment of planar polarity
0.40	GO:0045571	negative regulation of imaginal disc growth
0.40	GO:0048105	establishment of body hair planar orientation
0.40	GO:0035209	pupal development
0.40	GO:0044331	cell-cell adhesion mediated by cadherin
0.40	GO:0090251	protein localization involved in establishment of planar polarity

0.70	GO:0005509	calcium ion binding
0.38	GO:0045296	cadherin binding
0.37	GO:0004930	G-protein coupled receptor activity
0.35	GO:0042802	identical protein binding
0.33	GO:0030246	carbohydrate binding
0.33	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds

0.56	GO:0005886	plasma membrane
0.34	GO:0005615	extracellular space
0.33	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

0.33

GO:0004553

tr|T1G022|T1G022_HELRO
Uncharacterized protein
Search

0.63	GO:0006468	protein phosphorylation
0.43	GO:0035556	intracellular signal transduction
0.38	GO:0010825	positive regulation of centrosome duplication
0.37	GO:0006939	smooth muscle contraction
0.36	GO:0032956	regulation of actin cytoskeleton organization
0.36	GO:0018209	peptidyl-serine modification
0.36	GO:1905905	pharyngeal gland morphogenesis
0.36	GO:0016477	cell migration
0.36	GO:0060465	pharynx development
0.35	GO:0010172	embryonic body morphogenesis

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0046872	metal ion binding
0.36	GO:0017048	Rho GTPase binding
0.35	GO:0016849	phosphorus-oxygen lyase activity
0.33	GO:0004497	monooxygenase activity
0.33	GO:0004871	signal transducer activity
0.33	GO:0060089	molecular transducer activity

0.36	GO:0005622	intracellular
0.35	GO:0097610	cell surface furrow
0.35	GO:0005913	cell-cell adherens junction
0.35	GO:0032155	cell division site part
0.34	GO:0099512	supramolecular fiber
0.34	GO:0043227	membrane-bounded organelle
0.33	GO:0043228	non-membrane-bounded organelle
0.30	GO:0016020	membrane

0.35

EC:4.6

GO:0016849

tr|T1G023|T1G023_HELRO
Uncharacterized protein
Search

0.55	Actin-related protein 5

0.72	GO:0006338	chromatin remodeling
0.61	GO:0060303	regulation of nucleosome density
0.54	GO:0032392	DNA geometric change
0.49	GO:0006351	transcription, DNA-templated
0.49	GO:1903506	regulation of nucleic acid-templated transcription
0.49	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.48	GO:0010468	regulation of gene expression
0.43	GO:0006974	cellular response to DNA damage stimulus
0.42	GO:0006310	DNA recombination
0.37	GO:0006397	mRNA processing

0.59	GO:0043140	ATP-dependent 3'-5' DNA helicase activity
0.51	GO:0000062	fatty-acyl-CoA binding
0.39	GO:0003676	nucleic acid binding
0.38	GO:0008234	cysteine-type peptidase activity

0.73	GO:0031011	Ino80 complex
0.35	GO:0005829	cytosol
0.34	GO:0042729	DASH complex
0.34	GO:0072686	mitotic spindle
0.30	GO:0016020	membrane

0.38

GO:0008234

tr|T1G024|T1G024_HELRO
Uncharacterized protein
Search

0.50	Nucleolysin TIAR

0.45	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.32	GO:0055114	oxidation-reduction process

0.59	GO:0003723	RNA binding
0.33	GO:0003677	DNA binding
0.32	GO:0016491	oxidoreductase activity

0.34	GO:0019013	viral nucleocapsid
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0044425	membrane part

0.32

GO:0016491

tr|T1G025|T1G025_HELRO
Sodium/hydrogen exchanger
Search

0.42	Sodium/hydrogen exchanger

0.79	GO:0006885	regulation of pH
0.77	GO:0035725	sodium ion transmembrane transport
0.62	GO:1902600	hydrogen ion transmembrane transport
0.41	GO:0099587	inorganic ion import across plasma membrane
0.37	GO:0030004	cellular monovalent inorganic cation homeostasis
0.36	GO:0071805	potassium ion transmembrane transport

0.81	GO:0015385	sodium:proton antiporter activity
0.39	GO:0030165	PDZ domain binding
0.37	GO:0015386	potassium:proton antiporter activity

0.39	GO:0031526	brush border membrane
0.39	GO:0016324	apical plasma membrane
0.38	GO:0070062	extracellular exosome
0.33	GO:0009986	cell surface
0.30	GO:0016021	integral component of membrane

tr|T1G026|T1G026_HELRO
Uncharacterized protein
Search

ZFPL1

0.88	Zinc finger protein like 1

0.44	GO:0033227	dsRNA transport
0.37	GO:0016192	vesicle-mediated transport
0.34	GO:0032367	intracellular cholesterol transport
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:0010468	regulation of gene expression
0.32	GO:0055114	oxidation-reduction process

0.38	GO:0046872	metal ion binding
0.36	GO:0016874	ligase activity
0.33	GO:0008080	N-acetyltransferase activity
0.33	GO:0005515	protein binding
0.32	GO:0003677	DNA binding
0.32	GO:0016491	oxidoreductase activity

0.49	GO:0005794	Golgi apparatus
0.33	GO:0005634	nucleus
0.30	GO:0044425	membrane part

0.36

GO:0016874

tr|T1G027|T1G027_HELRO
Uncharacterized protein
Search

0.68	GO:0060285	cilium-dependent cell motility
0.36	GO:0023014	signal transduction by protein phosphorylation
0.35	GO:0000160	phosphorelay signal transduction system
0.34	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression

0.36

GO:0000155

phosphorelay sensor kinase activity

0.62	GO:0031514	motile cilium
0.33	GO:0005622	intracellular
0.30	GO:0044425	membrane part

0.36

EC:2.7.3

GO:0000155

tr|T1G028|T1G028_HELRO
Uncharacterized protein
Search

0.90	Tyrosine-protein kinase ZAP-70 TZK

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.54	GO:0007165	signal transduction
0.49	GO:0032502	developmental process
0.49	GO:0046777	protein autophosphorylation
0.48	GO:0032501	multicellular organismal process
0.47	GO:0002376	immune system process
0.46	GO:0016477	cell migration
0.46	GO:0042127	regulation of cell proliferation
0.46	GO:0001775	cell activation
0.46	GO:0051239	regulation of multicellular organismal process

0.77	GO:0004713	protein tyrosine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0019199	transmembrane receptor protein kinase activity
0.44	GO:0048407	platelet-derived growth factor binding
0.43	GO:0005102	receptor binding
0.42	GO:0032403	protein complex binding
0.41	GO:0038085	vascular endothelial growth factor binding

0.46	GO:0042101	T cell receptor complex
0.45	GO:0098552	side of membrane
0.43	GO:0005737	cytoplasm
0.42	GO:0005902	microvillus
0.42	GO:0019897	extrinsic component of plasma membrane
0.42	GO:0098857	membrane microdomain
0.41	GO:0030054	cell junction
0.41	GO:0001772	immunological synapse
0.40	GO:0009986	cell surface
0.39	GO:0019815	B cell receptor complex

0.77	EC:2.7.10	GO:0004713
0.33	KEGG:R04545	GO:0046934

tr|T1G029|T1G029_HELRO
Uncharacterized protein
Search

tr|T1G030|T1G030_HELRO
Uncharacterized protein
Search

0.30	52 kDa repressor of the inhibitor of the protein kinase (Fragment)

0.57

GO:0016310

phosphorylation

0.68	GO:0046983	protein dimerization activity
0.60	GO:0016301	kinase activity

tr|T1G031|T1G031_HELRO
Uncharacterized protein
Search

0.48	craniofacial development protein 2-like

tr|T1G032|T1G032_HELRO
Uncharacterized protein
Search

LOC106173137

0.86	neuronal acetylcholine receptor subunit alpha-10-like isoform X2

0.73	GO:0060079	excitatory postsynaptic potential
0.60	GO:0034220	ion transmembrane transport
0.40	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
0.40	GO:0007271	synaptic transmission, cholinergic
0.39	GO:0042472	inner ear morphogenesis
0.39	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.38	GO:0007018	microtubule-based movement
0.38	GO:0006816	calcium ion transport
0.38	GO:0042127	regulation of cell proliferation

0.76	GO:0005230	extracellular ligand-gated ion channel activity
0.76	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
0.70	GO:0022835	transmitter-gated channel activity
0.70	GO:0099600	transmembrane receptor activity
0.69	GO:0140135	mechanosensitive cation channel activity
0.38	GO:0005262	calcium channel activity
0.38	GO:0005515	protein binding
0.38	GO:0003777	microtubule motor activity
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008270	zinc ion binding

0.73	GO:0045211	postsynaptic membrane
0.69	GO:0030054	cell junction
0.40	GO:0043204	perikaryon
0.40	GO:0005892	acetylcholine-gated channel complex
0.39	GO:0030424	axon
0.38	GO:0016459	myosin complex

tr|T1G033|T1G033_HELRO
Uncharacterized protein
Search

0.96	Putative integral membrane protein s linking to the trans golgi network

0.74	GO:0000139	Golgi membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1G034|T1G034_HELRO
Uncharacterized protein
Search

0.62	Phosphopantothenoylcysteine decarboxylase

0.37	GO:0009651	response to salt stress
0.36	GO:0070207	protein homotrimerization
0.36	GO:0040008	regulation of growth
0.34	GO:0006972	hyperosmotic response
0.34	GO:0051128	regulation of cellular component organization
0.34	GO:0015937	coenzyme A biosynthetic process
0.33	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.33	GO:0030004	cellular monovalent inorganic cation homeostasis
0.33	GO:0007034	vacuolar transport

0.42	GO:0004633	phosphopantothenoylcysteine decarboxylase activity
0.35	GO:0010181	FMN binding
0.34	GO:0005509	calcium ion binding
0.33	GO:0004864	protein phosphatase inhibitor activity
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.33	GO:0042802	identical protein binding
0.32	GO:0003676	nucleic acid binding
0.32	GO:0032555	purine ribonucleotide binding

0.34	GO:0071513	phosphopantothenoylcysteine decarboxylase complex
0.34	GO:1990143	CoA-synthesizing protein complex
0.32	GO:0005634	nucleus

0.42	EC:4.1.1.36	GO:0004633
0.42	KEGG:R03269	GO:0004633

tr|T1G035|T1G035_HELRO
Uncharacterized protein
Search

0.49	Mitochondrial carrier protein Rim2

0.64	GO:0006839	mitochondrial transport
0.51	GO:0006862	nucleotide transport
0.47	GO:0055085	transmembrane transport
0.47	GO:0007005	mitochondrion organization
0.45	GO:0051881	regulation of mitochondrial membrane potential
0.45	GO:0006390	mitochondrial transcription
0.44	GO:0051646	mitochondrion localization
0.41	GO:1901264	carbohydrate derivative transport
0.40	GO:0040011	locomotion
0.38	GO:0045333	cellular respiration

0.48

GO:0015218

pyrimidine nucleotide transmembrane transporter activity

0.53	GO:0031966	mitochondrial membrane
0.38	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

tr|T1G036|T1G036_HELRO
Uncharacterized protein
Search

ACACA

0.53	Acetyl-Coenzyme A carboxylase alpha

0.70	GO:0006633	fatty acid biosynthetic process
0.58	GO:0044268	multicellular organismal protein metabolic process
0.56	GO:0071380	cellular response to prostaglandin E stimulus
0.55	GO:0051289	protein homotetramerization
0.53	GO:0001894	tissue homeostasis
0.53	GO:0055088	lipid homeostasis
0.50	GO:0006084	acetyl-CoA metabolic process
0.40	GO:2001295	malonyl-CoA biosynthetic process
0.38	GO:0009743	response to carbohydrate
0.36	GO:0019432	triglyceride biosynthetic process

0.76	GO:0004075	biotin carboxylase activity
0.76	GO:0003989	acetyl-CoA carboxylase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0046872	metal ion binding
0.50	GO:0042802	identical protein binding
0.36	GO:0032810	sterol response element binding
0.36	GO:0050692	DBD domain binding

0.54	GO:0001650	fibrillar center
0.50	GO:0015629	actin cytoskeleton
0.48	GO:0005829	cytosol
0.44	GO:0005739	mitochondrion
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.76

EC:6.3.4.14

GO:0004075

tr|T1G037|T1G037_HELRO
Uncharacterized protein
Search

0.10	Glutamate dehydrogenase (Fragment)

0.59	GO:0006520	cellular amino acid metabolic process
0.52	GO:0055114	oxidation-reduction process
0.48	GO:0032024	positive regulation of insulin secretion
0.43	GO:0072350	tricarboxylic acid metabolic process
0.39	GO:0043649	dicarboxylic acid catabolic process
0.37	GO:0021762	substantia nigra development
0.37	GO:0043650	dicarboxylic acid biosynthetic process
0.37	GO:0010044	response to aluminum ion
0.37	GO:0007616	long-term memory
0.37	GO:1901565	organonitrogen compound catabolic process

0.74	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
0.41	GO:0070728	leucine binding
0.38	GO:0043531	ADP binding
0.38	GO:0070403	NAD+ binding
0.37	GO:0032550	purine ribonucleoside binding
0.37	GO:0019001	guanyl nucleotide binding
0.35	GO:0019899	enzyme binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0008144	drug binding
0.34	GO:0042802	identical protein binding

0.45	GO:0005759	mitochondrial matrix
0.39	GO:0031966	mitochondrial membrane
0.39	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.74

EC:1.4.1

GO:0016639

tr|T1G038|T1G038_HELRO
Uncharacterized protein
Search

0.79	GO:0046426	negative regulation of JAK-STAT cascade
0.66	GO:0016567	protein ubiquitination
0.64	GO:0001558	regulation of cell growth
0.61	GO:0035556	intracellular signal transduction
0.59	GO:0060330	regulation of response to interferon-gamma
0.56	GO:0060749	mammary gland alveolus development
0.56	GO:0040015	negative regulation of multicellular organism growth
0.55	GO:0060396	growth hormone receptor signaling pathway
0.55	GO:0007595	lactation
0.55	GO:0032355	response to estradiol

0.72	GO:0008269	JAK pathway signal transduction adaptor activity
0.72	GO:0005159	insulin-like growth factor receptor binding
0.55	GO:0005131	growth hormone receptor binding
0.49	GO:0019210	kinase inhibitor activity
0.46	GO:0019887	protein kinase regulator activity
0.42	GO:0001784	phosphotyrosine residue binding
0.38	GO:0019901	protein kinase binding
0.35	GO:0005070	SH3/SH2 adaptor activity
0.34	GO:0004402	histone acetyltransferase activity
0.34	GO:0003743	translation initiation factor activity

0.46	GO:0005737	cytoplasm
0.38	GO:0035770	ribonucleoprotein granule
0.37	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.34

GO:0004402

tr|T1G039|T1G039_HELRO
Uncharacterized protein
Search

0.39	tyrosine-protein kinase Fer

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.49	GO:0042058	regulation of epidermal growth factor receptor signaling pathway
0.49	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.48	GO:0030036	actin cytoskeleton organization
0.48	GO:0030335	positive regulation of cell migration
0.47	GO:0008283	cell proliferation
0.45	GO:0046664	dorsal closure, amnioserosa morphology change
0.45	GO:0007394	dorsal closure, elongation of leading edge cells
0.45	GO:0000904	cell morphogenesis involved in differentiation
0.44	GO:0006928	movement of cell or subcellular component

0.77	GO:0004713	protein tyrosine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0005154	epidermal growth factor receptor binding
0.41	GO:0008157	protein phosphatase 1 binding
0.39	GO:0008289	lipid binding
0.34	GO:0008270	zinc ion binding
0.34	GO:0019135	deoxyhypusine monooxygenase activity

0.45	GO:0019898	extrinsic component of membrane
0.44	GO:0030054	cell junction
0.43	GO:0005856	cytoskeleton
0.42	GO:0009898	cytoplasmic side of plasma membrane
0.41	GO:0030027	lamellipodium
0.39	GO:0000790	nuclear chromatin
0.38	GO:0005829	cytosol
0.34	GO:0005938	cell cortex

0.77

GO:0004713

tr|T1G040|T1G040_HELRO
Uncharacterized protein
Search

CREM

0.65	cAMP responsive element modulator b

0.47	GO:2001141	regulation of RNA biosynthetic process
0.47	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.46	GO:0010468	regulation of gene expression
0.44	GO:0060509	Type I pneumocyte differentiation
0.44	GO:0060430	lung saccule development
0.44	GO:0071294	cellular response to zinc ion
0.44	GO:0035729	cellular response to hepatocyte growth factor stimulus
0.43	GO:0033762	response to glucagon
0.43	GO:0045672	positive regulation of osteoclast differentiation
0.43	GO:0033363	secretory granule organization

0.49	GO:0003700	DNA binding transcription factor activity
0.45	GO:0003677	DNA binding
0.42	GO:0001102	RNA polymerase II activating transcription factor binding
0.42	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.42	GO:0001067	regulatory region nucleic acid binding
0.40	GO:0042802	identical protein binding
0.39	GO:0019899	enzyme binding
0.34	GO:0001225	RNA polymerase II transcription coactivator binding
0.34	GO:1990763	arrestin family protein binding
0.34	GO:0030544	Hsp70 protein binding

0.49	GO:0005634	nucleus
0.42	GO:0000791	euchromatin
0.41	GO:0005667	transcription factor complex
0.38	GO:0070013	intracellular organelle lumen
0.33	GO:0030424	axon
0.32	GO:0044429	mitochondrial part

tr|T1G041|T1G041_HELRO
Uncharacterized protein
Search

tr|T1G042|T1G042_HELRO
Uncharacterized protein
Search

0.79	Mitochondrial cytochrome c oxidase subunit Va

0.63	GO:1902600	hydrogen ion transmembrane transport
0.61	GO:0022900	electron transport chain
0.46	GO:0007406	negative regulation of neuroblast proliferation
0.43	GO:0045787	positive regulation of cell cycle
0.37	GO:0006119	oxidative phosphorylation
0.37	GO:0009060	aerobic respiration
0.37	GO:0021522	spinal cord motor neuron differentiation
0.36	GO:0048568	embryonic organ development
0.35	GO:0019264	glycine biosynthetic process from serine
0.34	GO:0035999	tetrahydrofolate interconversion

0.65	GO:0015002	heme-copper terminal oxidase activity
0.65	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.62	GO:0009055	electron transfer activity
0.35	GO:0004372	glycine hydroxymethyltransferase activity
0.34	GO:0046872	metal ion binding
0.34	GO:0030170	pyridoxal phosphate binding
0.33	GO:0004386	helicase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane
0.39	GO:0045277	respiratory chain complex IV
0.39	GO:0098798	mitochondrial protein complex
0.35	GO:0043209	myelin sheath
0.30	GO:0031224	intrinsic component of membrane

0.65

EC:1.9.3

GO:0016676

tr|T1G043|T1G043_HELRO
Uncharacterized protein
Search

CADPS

0.69	Calcium-dependent secretion activator

0.85	GO:1990504	dense core granule exocytosis
0.84	GO:0016079	synaptic vesicle exocytosis
0.42	GO:0045921	positive regulation of exocytosis
0.40	GO:0140029	exocytic process
0.40	GO:0009267	cellular response to starvation
0.38	GO:0043623	cellular protein complex assembly
0.36	GO:0006629	lipid metabolic process
0.36	GO:0035556	intracellular signal transduction
0.35	GO:0035249	synaptic transmission, glutamatergic
0.35	GO:0017158	regulation of calcium ion-dependent exocytosis

0.40	GO:0004435	phosphatidylinositol phospholipase C activity
0.36	GO:0004871	signal transducer activity
0.34	GO:0008289	lipid binding
0.33	GO:0005509	calcium ion binding

0.79	GO:0098793	presynapse
0.40	GO:0045211	postsynaptic membrane
0.39	GO:0031410	cytoplasmic vesicle
0.38	GO:0005654	nucleoplasm
0.34	GO:0012506	vesicle membrane
0.34	GO:0030054	cell junction
0.33	GO:0012505	endomembrane system
0.30	GO:0016021	integral component of membrane

0.40	EC:3.1.4.11	GO:0004435
0.40	KEGG:R03435	GO:0004435

tr|T1G044|T1G044_HELRO
Uncharacterized protein
Search

0.84	Metal tolerance protein 7

0.61	GO:0098655	cation transmembrane transport
0.37	GO:0006828	manganese ion transport
0.35	GO:0098660	inorganic ion transmembrane transport

0.61	GO:0008324	cation transmembrane transporter activity
0.34	GO:0015318	inorganic molecular entity transmembrane transporter activity

0.41	GO:0005774	vacuolar membrane
0.39	GO:0035618	root hair
0.38	GO:0000325	plant-type vacuole
0.30	GO:0031224	intrinsic component of membrane

tr|T1G045|T1G045_HELRO
Uncharacterized protein
Search

LOC100184611

0.68	Heterogeneous nuclear ribonucleoprotein F

0.44	GO:0006396	RNA processing
0.35	GO:1904973	positive regulation of viral translation
0.35	GO:1905698	positive regulation of polysome binding
0.34	GO:0039695	DNA-templated viral transcription
0.34	GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
0.34	GO:0035549	positive regulation of interferon-beta secretion
0.34	GO:0070934	CRD-mediated mRNA stabilization
0.34	GO:0046833	positive regulation of RNA export from nucleus
0.34	GO:1903608	protein localization to cytoplasmic stress granule
0.34	GO:1904469	positive regulation of tumor necrosis factor secretion

0.57	GO:0003723	RNA binding
0.35	GO:0033681	ATP-dependent 3'-5' DNA/RNA helicase activity
0.35	GO:1905172	RISC complex binding
0.34	GO:0005267	potassium channel activity
0.34	GO:1905538	polysome binding
0.34	GO:0045142	triplex DNA binding
0.34	GO:0061676	importin-alpha family protein binding
0.34	GO:1990518	single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity
0.34	GO:1990841	promoter-specific chromatin binding
0.34	GO:0001105	RNA polymerase II transcription coactivator activity

0.47	GO:0019013	viral nucleocapsid
0.43	GO:0030529	intracellular ribonucleoprotein complex
0.34	GO:0005726	perichromatin fibrils
0.34	GO:0070937	CRD-mediated mRNA stability complex
0.34	GO:0070578	RISC-loading complex
0.33	GO:0005813	centrosome
0.33	GO:0016604	nuclear body
0.33	GO:0015629	actin cytoskeleton
0.33	GO:0042597	periplasmic space
0.30	GO:0016020	membrane

0.33

EC:3.6.1.19

GO:0047429

tr|T1G046|T1G046_HELRO
Uncharacterized protein
Search

0.30	Transmembrane protein 136a

0.30

GO:0044425

membrane part

tr|T1G047|T1G047_HELRO
Uncharacterized protein
Search

0.81	gonadotropin-releasing hormone II receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.49	GO:0035690	cellular response to drug
0.48	GO:1901701	cellular response to oxygen-containing compound
0.48	GO:0071310	cellular response to organic substance
0.48	GO:1901699	cellular response to nitrogen compound
0.47	GO:1905144	response to acetylcholine
0.46	GO:0071495	cellular response to endogenous stimulus
0.43	GO:0070328	triglyceride homeostasis
0.43	GO:0006117	acetaldehyde metabolic process
0.42	GO:0033500	carbohydrate homeostasis

0.72	GO:0004930	G-protein coupled receptor activity
0.64	GO:0016500	protein-hormone receptor activity
0.59	GO:0001653	peptide receptor activity
0.47	GO:0015464	acetylcholine receptor activity
0.46	GO:0097004	adipokinetic hormone binding
0.34	GO:0050254	rhodopsin kinase activity
0.33	GO:0005515	protein binding
0.33	GO:0005509	calcium ion binding
0.33	GO:0042923	neuropeptide binding
0.31	GO:0003723	RNA binding

0.46	GO:0045211	postsynaptic membrane
0.45	GO:0005887	integral component of plasma membrane
0.44	GO:0030054	cell junction
0.32	GO:0043005	neuron projection
0.32	GO:0005654	nucleoplasm

0.34

GO:0050254

tr|T1G048|T1G048_HELRO
Uncharacterized protein
Search

tr|T1G049|T1G049_HELRO
Uncharacterized protein
Search

0.17	RNA-binding protein

0.37	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
0.36	GO:0046686	response to cadmium ion
0.36	GO:0000380	alternative mRNA splicing, via spliceosome
0.36	GO:0002218	activation of innate immune response
0.35	GO:0000122	negative regulation of transcription by RNA polymerase II
0.35	GO:0000724	double-strand break repair via homologous recombination
0.35	GO:0045944	positive regulation of transcription by RNA polymerase II

0.54	GO:0003723	RNA binding
0.36	GO:0042826	histone deacetylase binding
0.35	GO:0044212	transcription regulatory region DNA binding
0.35	GO:0042803	protein homodimerization activity

0.43	GO:0005737	cytoplasm
0.37	GO:0042382	paraspeckles
0.36	GO:0016363	nuclear matrix
0.35	GO:0000785	chromatin
0.30	GO:0016020	membrane

tr|T1G050|T1G050_HELRO
Uncharacterized protein
Search

TEKT5

0.85	Putative cystoskeletal protein tektin

0.70	GO:0060294	cilium movement involved in cell motility
0.70	GO:0030317	flagellated sperm motility
0.66	GO:0060271	cilium assembly
0.48	GO:0080154	regulation of fertilization
0.42	GO:0046692	sperm competition
0.40	GO:0007020	microtubule nucleation
0.35	GO:0007165	signal transduction
0.33	GO:0006508	proteolysis

0.39	GO:0005200	structural constituent of cytoskeleton
0.36	GO:0003924	GTPase activity
0.36	GO:0032550	purine ribonucleoside binding
0.36	GO:0019001	guanyl nucleotide binding
0.35	GO:0005515	protein binding
0.34	GO:0032555	purine ribonucleotide binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0004252	serine-type endopeptidase activity

0.75	GO:0036126	sperm flagellum
0.50	GO:0005634	nucleus
0.42	GO:0015630	microtubule cytoskeleton
0.37	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.34

GO:0004252

tr|T1G051|T1G051_HELRO
Uncharacterized protein
Search

0.54	Zinc finger MYM-type protein 1

0.36	GO:0006357	regulation of transcription by RNA polymerase II
0.35	GO:0007275	multicellular organism development
0.33	GO:0016310	phosphorylation

0.68	GO:0046983	protein dimerization activity
0.36	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.35	GO:0003677	DNA binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0016301	kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.36	GO:0005654	nucleoplasm
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

tr|T1G052|T1G052_HELRO
Uncharacterized protein
Search

tr|T1G053|T1G053_HELRO
Uncharacterized protein
Search

0.85

Complexin

0.76	GO:0006836	neurotransmitter transport
0.36	GO:0006887	exocytosis
0.35	GO:0046929	negative regulation of neurotransmitter secretion
0.35	GO:0051124	synaptic growth at neuromuscular junction
0.35	GO:0007274	neuromuscular synaptic transmission
0.34	GO:0048489	synaptic vesicle transport
0.34	GO:0099504	synaptic vesicle cycle
0.34	GO:0099643	signal release from synapse
0.34	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.33	GO:0070489	T cell aggregation

0.83	GO:0019905	syntaxin binding
0.34	GO:0005326	neurotransmitter transporter activity
0.33	GO:0030674	protein binding, bridging
0.33	GO:0050839	cell adhesion molecule binding
0.33	GO:0045735	nutrient reservoir activity
0.33	GO:0019901	protein kinase binding
0.33	GO:0003725	double-stranded RNA binding
0.32	GO:0003779	actin binding
0.32	GO:0005102	receptor binding
0.32	GO:0003677	DNA binding

0.35	GO:0043195	terminal bouton
0.34	GO:0031594	neuromuscular junction
0.34	GO:0048786	presynaptic active zone
0.33	GO:0005829	cytosol
0.33	GO:0001931	uropod
0.33	GO:0031528	microvillus membrane
0.33	GO:0031527	filopodium membrane
0.33	GO:0071437	invadopodium
0.33	GO:0031143	pseudopodium
0.33	GO:0030315	T-tubule

tr|T1G054|T1G054_HELRO
Uncharacterized protein
Search

0.76	GO:0043113	receptor clustering
0.73	GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
0.45	GO:0006898	receptor-mediated endocytosis
0.40	GO:0045995	regulation of embryonic development
0.39	GO:0030154	cell differentiation
0.39	GO:0030334	regulation of cell migration
0.39	GO:0007275	multicellular organism development
0.38	GO:0030155	regulation of cell adhesion
0.38	GO:0009653	anatomical structure morphogenesis
0.38	GO:0007155	cell adhesion

0.76	GO:0043236	laminin binding
0.67	GO:0005509	calcium ion binding
0.48	GO:0005044	scavenger receptor activity
0.38	GO:0005102	receptor binding
0.36	GO:0035374	chondroitin sulfate binding
0.36	GO:0033691	sialic acid binding
0.35	GO:0002162	dystroglycan binding
0.35	GO:0043395	heparan sulfate proteoglycan binding
0.35	GO:0008061	chitin binding
0.34	GO:0005200	structural constituent of cytoskeleton

0.51	GO:0005886	plasma membrane
0.50	GO:0005605	basal lamina
0.42	GO:0005829	cytosol
0.36	GO:0012505	endomembrane system
0.35	GO:0043202	lysosomal lumen
0.35	GO:0070062	extracellular exosome
0.34	GO:0045202	synapse
0.34	GO:0030054	cell junction
0.34	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

0.33

GO:0008233

tr|T1G055|T1G055_HELRO
Protein kinase C
Search

PRKCZ

0.91	Protein kinase C zeta type

0.63	GO:0006468	protein phosphorylation
0.60	GO:0035556	intracellular signal transduction
0.58	GO:0007163	establishment or maintenance of cell polarity
0.57	GO:2001181	positive regulation of interleukin-10 secretion
0.57	GO:2000667	positive regulation of interleukin-13 secretion
0.57	GO:0045630	positive regulation of T-helper 2 cell differentiation
0.57	GO:2000664	positive regulation of interleukin-5 secretion
0.57	GO:2000553	positive regulation of T-helper 2 cell cytokine production
0.55	GO:0032753	positive regulation of interleukin-4 production
0.54	GO:0046627	negative regulation of insulin receptor signaling pathway

0.80	GO:0004697	protein kinase C activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0046872	metal ion binding
0.39	GO:0043274	phospholipase binding
0.39	GO:0071889	14-3-3 protein binding
0.39	GO:0019904	protein domain specific binding
0.39	GO:0015459	potassium channel regulator activity

0.56	GO:0035748	myelin sheath abaxonal region
0.56	GO:0043203	axon hillock
0.54	GO:0045179	apical cortex
0.53	GO:0016363	nuclear matrix
0.52	GO:0016324	apical plasma membrane
0.52	GO:0043296	apical junction complex
0.51	GO:0070160	occluding junction
0.49	GO:0005635	nuclear envelope
0.49	GO:0005815	microtubule organizing center
0.48	GO:0031982	vesicle

0.80

EC:2.7.11.13

GO:0004697

tr|T1G056|T1G056_HELRO
Uncharacterized protein
Search

0.20	ATP-dependent DNA helicase

0.79	GO:0000723	telomere maintenance
0.70	GO:0032392	DNA geometric change
0.65	GO:0006310	DNA recombination
0.65	GO:0006281	DNA repair
0.36	GO:0006413	translational initiation

0.71	GO:0003678	DNA helicase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0003743	translation initiation factor activity

tr|T1G057|T1G057_HELRO
Uncharacterized protein
Search

TXN2

0.31	Thioredoxin, mitochondrial

0.74	GO:0006662	glycerol ether metabolic process
0.69	GO:0045454	cell redox homeostasis
0.52	GO:0055114	oxidation-reduction process
0.39	GO:0034599	cellular response to oxidative stress
0.39	GO:0080058	protein deglutathionylation
0.38	GO:0000011	vacuole inheritance
0.37	GO:0042144	vacuole fusion, non-autophagic
0.37	GO:0098869	cellular oxidant detoxification
0.37	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.36	GO:0006888	ER to Golgi vesicle-mediated transport

0.71	GO:0015035	protein disulfide oxidoreductase activity
0.39	GO:0047134	protein-disulfide reductase activity
0.39	GO:0004791	thioredoxin-disulfide reductase activity
0.38	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
0.34	GO:0008047	enzyme activator activity
0.33	GO:0046872	metal ion binding

0.37	GO:0005739	mitochondrion
0.37	GO:0000324	fungal-type vacuole
0.36	GO:0031970	organelle envelope lumen
0.36	GO:0005829	cytosol
0.34	GO:0009570	chloroplast stroma
0.33	GO:0031984	organelle subcompartment
0.33	GO:0034399	nuclear periphery
0.33	GO:0044431	Golgi apparatus part
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0009579	thylakoid

0.39	EC:1.8.1.8	GO:0047134
0.39	KEGG:R02016	GO:0004791

tr|T1G058|T1G058_HELRO
Protein disulfide-isomerase
Search

PDIA3

0.48	Protein disulfide-isomerase

0.67	GO:0045454	cell redox homeostasis
0.41	GO:0034976	response to endoplasmic reticulum stress
0.39	GO:0006457	protein folding
0.38	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
0.35	GO:0090597	nematode male tail mating organ morphogenesis
0.35	GO:0080058	protein deglutathionylation
0.35	GO:0040002	collagen and cuticulin-based cuticle development
0.35	GO:0045138	nematode male tail tip morphogenesis
0.35	GO:0018991	oviposition
0.35	GO:0040019	positive regulation of embryonic development

0.80	GO:0003756	protein disulfide isomerase activity
0.37	GO:0015037	peptide disulfide oxidoreductase activity
0.36	GO:0042802	identical protein binding
0.34	GO:0003810	protein-glutamine gamma-glutamyltransferase activity
0.33	GO:0016757	transferase activity, transferring glycosyl groups
0.32	GO:0003676	nucleic acid binding

0.68	GO:0005783	endoplasmic reticulum
0.38	GO:0009986	cell surface
0.37	GO:0043209	myelin sheath
0.36	GO:0043233	organelle lumen
0.36	GO:0005615	extracellular space
0.35	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.80

EC:5.3.4.1

GO:0003756

tr|T1G059|T1G059_HELRO
Uncharacterized protein
Search

0.10	RAN binding protein 9 (Fragment)

0.54	GO:0007010	cytoskeleton organization
0.48	GO:0007017	microtubule-based process
0.48	GO:0030029	actin filament-based process
0.48	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.46	GO:0022604	regulation of cell morphogenesis
0.46	GO:0060041	retina development in camera-type eye
0.46	GO:0065009	regulation of molecular function

0.58	GO:0019899	enzyme binding
0.54	GO:0008092	cytoskeletal protein binding
0.47	GO:0098772	molecular function regulator
0.39	GO:0003723	RNA binding

0.54	GO:0005634	nucleus
0.53	GO:0005881	cytoplasmic microtubule
0.30	GO:0031224	intrinsic component of membrane

tr|T1G060|T1G060_HELRO
Uncharacterized protein
Search

0.74	RFX-like transcription factor daf-19 (inferred by orthology to a C. elegans protein)

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.45	GO:0007605	sensory perception of sound
0.43	GO:0007399	nervous system development
0.41	GO:0016358	dendrite development
0.40	GO:0120036	plasma membrane bounded cell projection organization
0.40	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.40	GO:0000904	cell morphogenesis involved in differentiation
0.35	GO:0001675	acrosome assembly

0.54	GO:0003677	DNA binding
0.39	GO:0001067	regulatory region nucleic acid binding
0.36	GO:0003700	DNA binding transcription factor activity

0.39	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1G061|T1G061_HELRO
Uncharacterized protein
Search

0.73	Glutamate dehydrogenase 1, mitochondrial (Fragment)

0.57	GO:0006520	cellular amino acid metabolic process
0.51	GO:0055114	oxidation-reduction process
0.46	GO:0032024	positive regulation of insulin secretion
0.42	GO:0072350	tricarboxylic acid metabolic process
0.41	GO:0032094	response to food
0.40	GO:0043649	dicarboxylic acid catabolic process
0.38	GO:0043650	dicarboxylic acid biosynthetic process
0.38	GO:1901565	organonitrogen compound catabolic process
0.37	GO:0021762	substantia nigra development
0.37	GO:0010044	response to aluminum ion

0.71	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
0.42	GO:0070728	leucine binding
0.39	GO:0043531	ADP binding
0.38	GO:0032550	purine ribonucleoside binding
0.38	GO:0019001	guanyl nucleotide binding
0.37	GO:0070403	NAD+ binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005515	protein binding
0.34	GO:0008144	drug binding

0.45	GO:0005759	mitochondrial matrix
0.39	GO:0031966	mitochondrial membrane
0.39	GO:0019866	organelle inner membrane

0.71

EC:1.4.1

GO:0016639

tr|T1G062|T1G062_HELRO
Uncharacterized protein
Search

tr|T1G063|T1G063_HELRO
Uncharacterized protein
Search

PTDSS1

0.57	Phosphatidylserine synthase

0.85	GO:0006659	phosphatidylserine biosynthetic process
0.41	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation
0.39	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.34	GO:0006397	mRNA processing
0.33	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.32	GO:0006468	protein phosphorylation

0.42	GO:0000213	tRNA-intron endonuclease activity
0.35	GO:0003676	nucleic acid binding
0.34	GO:0016740	transferase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0004888	transmembrane signaling receptor activity
0.32	GO:0140096	catalytic activity, acting on a protein

0.42	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.42

EC:3.1.27.9

GO:0000213

tr|T1G064|T1G064_HELRO
Uncharacterized protein
Search

TEKT4

0.78	Tektin-4 isoform B

0.76	GO:0060294	cilium movement involved in cell motility
0.72	GO:0060271	cilium assembly
0.72	GO:0030317	flagellated sperm motility
0.39	GO:0080154	regulation of fertilization
0.35	GO:0007165	signal transduction
0.33	GO:0006508	proteolysis

0.37	GO:0005515	protein binding
0.36	GO:0003924	GTPase activity
0.36	GO:0032550	purine ribonucleoside binding
0.36	GO:0019001	guanyl nucleotide binding
0.34	GO:0032555	purine ribonucleotide binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0004252	serine-type endopeptidase activity

0.78	GO:0036126	sperm flagellum
0.54	GO:0005634	nucleus
0.39	GO:0015630	microtubule cytoskeleton
0.39	GO:0044430	cytoskeletal part
0.38	GO:0099512	supramolecular fiber
0.35	GO:0005737	cytoplasm
0.34	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.34

GO:0004252

tr|T1G065|T1G065_HELRO
Innexin
Search

INX

0.56

Innexin

0.58	GO:0006811	ion transport
0.36	GO:0048598	embryonic morphogenesis
0.35	GO:0007186	G-protein coupled receptor signaling pathway
0.35	GO:0006367	transcription initiation from RNA polymerase II promoter
0.34	GO:0010644	cell communication by electrical coupling
0.33	GO:0055085	transmembrane transport
0.33	GO:1900194	negative regulation of oocyte maturation

0.36	GO:0005243	gap junction channel activity
0.35	GO:0004930	G-protein coupled receptor activity

0.80	GO:0005921	gap junction
0.55	GO:0005886	plasma membrane
0.35	GO:0005669	transcription factor TFIID complex
0.33	GO:0045202	synapse
0.33	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

tr|T1G066|T1G066_HELRO
Uncharacterized protein
Search

0.88	Immediate early response 3-interacting protein 1

0.40	GO:0006888	ER to Golgi vesicle-mediated transport
0.36	GO:2000269	regulation of fibroblast apoptotic process
0.34	GO:0045721	negative regulation of gluconeogenesis
0.33	GO:0032502	developmental process
0.33	GO:0006886	intracellular protein transport

0.34

GO:0019899

enzyme binding

0.41	GO:0030173	integral component of Golgi membrane
0.40	GO:0030134	COPII-coated ER to Golgi transport vesicle
0.39	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0030123	AP-3 adaptor complex

tr|T1G067|T1G067_HELRO
Uncharacterized protein
Search

0.51	Neuronal calcium sensor

0.33	GO:0006508	proteolysis
0.33	GO:0005975	carbohydrate metabolic process

0.70	GO:0005509	calcium ion binding
0.34	GO:0008061	chitin binding
0.33	GO:0004252	serine-type endopeptidase activity

0.30

GO:0031224

intrinsic component of membrane

0.33

GO:0004252

tr|T1G068|T1G068_HELRO
Uncharacterized protein
Search

tr|T1G069|T1G069_HELRO
Uncharacterized protein
Search

0.79	GO:0008543	fibroblast growth factor receptor signaling pathway
0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.75	GO:0008284	positive regulation of cell proliferation
0.45	GO:2000830	positive regulation of parathyroid hormone secretion
0.44	GO:0021769	orbitofrontal cortex development
0.44	GO:0048378	regulation of lateral mesodermal cell fate specification
0.44	GO:0021847	ventricular zone neuroblast division
0.44	GO:1903465	positive regulation of mitotic cell cycle DNA replication
0.44	GO:1904849	positive regulation of cell chemotaxis to fibroblast growth factor
0.44	GO:0090272	negative regulation of fibroblast growth factor production

0.83	GO:0005007	fibroblast growth factor-activated receptor activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0090722	receptor-receptor interaction
0.44	GO:0017134	fibroblast growth factor binding
0.40	GO:0042803	protein homodimerization activity
0.40	GO:1901681	sulfur compound binding
0.33	GO:0008270	zinc ion binding

0.41	GO:0043235	receptor complex
0.40	GO:0005730	nucleolus
0.37	GO:0005886	plasma membrane
0.35	GO:0031410	cytoplasmic vesicle
0.34	GO:0005783	endoplasmic reticulum
0.34	GO:0005911	cell-cell junction
0.33	GO:0005794	Golgi apparatus
0.33	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

tr|T1G070|T1G070_HELRO
Uncharacterized protein
Search

0.69	GO:0071526	semaphorin-plexin signaling pathway
0.59	GO:0006893	Golgi to plasma membrane transport
0.56	GO:0033689	negative regulation of osteoblast proliferation
0.56	GO:0061430	bone trabecula morphogenesis
0.56	GO:0043931	ossification involved in bone maturation
0.54	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
0.54	GO:0050772	positive regulation of axonogenesis
0.51	GO:0048812	neuron projection morphogenesis
0.50	GO:0043547	positive regulation of GTPase activity
0.47	GO:0008360	regulation of cell shape

0.69	GO:0017154	semaphorin receptor activity
0.56	GO:0032794	GTPase activating protein binding
0.30	GO:0003824	catalytic activity

0.56	GO:0000145	exocyst
0.30	GO:0016020	membrane

tr|T1G071|T1G071_HELRO
Uncharacterized protein
Search

0.76

GO:0010951

negative regulation of endopeptidase activity

0.83

GO:0004869

cysteine-type endopeptidase inhibitor activity

0.45

GO:0005622

intracellular

tr|T1G072|T1G072_HELRO
Uncharacterized protein
Search

0.37	GO:0036211	protein modification process
0.37	GO:0000724	double-strand break repair via homologous recombination
0.36	GO:1902975	mitotic DNA replication initiation
0.36	GO:0044267	cellular protein metabolic process
0.36	GO:0006741	NADP biosynthetic process
0.36	GO:0032508	DNA duplex unwinding
0.36	GO:0016310	phosphorylation
0.35	GO:0065007	biological regulation
0.35	GO:0019674	NAD metabolic process
0.35	GO:0023052	signaling

0.37	GO:0043138	3'-5' DNA helicase activity
0.36	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.36	GO:0140096	catalytic activity, acting on a protein
0.36	GO:0016301	kinase activity
0.36	GO:0097367	carbohydrate derivative binding
0.36	GO:0017076	purine nucleotide binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0008144	drug binding
0.35	GO:0005515	protein binding
0.35	GO:0003700	DNA binding transcription factor activity

0.36	GO:0005634	nucleus
0.35	GO:0005694	chromosome
0.35	GO:0043234	protein complex
0.35	GO:0032993	protein-DNA complex
0.34	GO:0000159	protein phosphatase type 2A complex
0.34	GO:0070013	intracellular organelle lumen
0.34	GO:0005576	extracellular region
0.34	GO:0099023	tethering complex
0.34	GO:0005737	cytoplasm
0.33	GO:0048475	coated membrane

0.36

GO:0016773

tr|T1G073|T1G073_HELRO
Uncharacterized protein
Search

DYNLRB1

0.82	Dynein light chain roadblock

0.71	GO:0007018	microtubule-based movement
0.43	GO:0016319	mushroom body development
0.42	GO:0048813	dendrite morphogenesis
0.38	GO:0007632	visual behavior
0.36	GO:0030705	cytoskeleton-dependent intracellular transport
0.35	GO:0007179	transforming growth factor beta receptor signaling pathway
0.34	GO:0031503	protein complex localization
0.34	GO:0060285	cilium-dependent cell motility
0.34	GO:0060271	cilium assembly
0.34	GO:0006914	autophagy

0.81	GO:0045505	dynein intermediate chain binding
0.68	GO:0003774	motor activity
0.35	GO:0042802	identical protein binding
0.33	GO:0042623	ATPase activity, coupled

0.79	GO:0005868	cytoplasmic dynein complex
0.69	GO:0005874	microtubule
0.51	GO:0005929	cilium
0.49	GO:0032838	plasma membrane bounded cell projection cytoplasm
0.45	GO:0005813	centrosome
0.34	GO:0033267	axon part
0.30	GO:0016020	membrane

tr|T1G074|T1G074_HELRO
Uncharacterized protein
Search

tr|T1G075|T1G075_HELRO
Uncharacterized protein
Search

tr|T1G076|T1G076_HELRO
Uncharacterized protein
Search

LHX1

0.93	LIM homeobox protein 5

0.66	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
0.65	GO:0021527	spinal cord association neuron differentiation
0.65	GO:0021702	cerebellar Purkinje cell differentiation
0.61	GO:0030900	forebrain development
0.58	GO:2000744	positive regulation of anterior head development
0.58	GO:0097477	lateral motor column neuron migration
0.58	GO:2000768	positive regulation of nephron tubule epithelial cell differentiation
0.58	GO:0061205	paramesonephric duct development
0.57	GO:0072049	comma-shaped body morphogenesis
0.57	GO:0035847	uterine epithelium development

0.65	GO:0043565	sequence-specific DNA binding
0.54	GO:0046872	metal ion binding
0.44	GO:0003700	DNA binding transcription factor activity
0.43	GO:0003714	transcription corepressor activity
0.35	GO:0005515	protein binding
0.35	GO:0035326	enhancer binding
0.34	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.43	GO:0043234	protein complex
0.30	GO:0016020	membrane

tr|T1G077|T1G077_HELRO
Uncharacterized protein
Search

0.76	GO:0043401	steroid hormone mediated signaling pathway
0.70	GO:0030522	intracellular receptor signaling pathway
0.56	GO:0006351	transcription, DNA-templated
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:2001141	regulation of RNA biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.37	GO:0034772	histone H4-K20 dimethylation
0.36	GO:0034773	histone H4-K20 trimethylation
0.35	GO:0032012	regulation of ARF protein signal transduction
0.34	GO:0009190	cyclic nucleotide biosynthetic process

0.77	GO:0003707	steroid hormone receptor activity
0.75	GO:0004887	thyroid hormone receptor activity
0.58	GO:0043565	sequence-specific DNA binding
0.58	GO:0008270	zinc ion binding
0.36	GO:0042799	histone methyltransferase activity (H4-K20 specific)
0.35	GO:0005086	ARF guanyl-nucleotide exchange factor activity
0.35	GO:0008528	G-protein coupled peptide receptor activity
0.34	GO:0005543	phospholipid binding
0.34	GO:0016849	phosphorus-oxygen lyase activity
0.33	GO:0004672	protein kinase activity

0.60	GO:0005634	nucleus
0.36	GO:0005700	polytene chromosome
0.35	GO:0000792	heterochromatin
0.34	GO:0043233	organelle lumen
0.30	GO:0016020	membrane

0.34

EC:4.6

GO:0016849

tr|T1G078|T1G078_HELRO
Uncharacterized protein
Search

0.46	GO:1903506	regulation of nucleic acid-templated transcription
0.46	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.45	GO:0010468	regulation of gene expression
0.42	GO:1902679	negative regulation of RNA biosynthetic process
0.41	GO:0006351	transcription, DNA-templated

0.51	GO:0003676	nucleic acid binding
0.45	GO:0046872	metal ion binding
0.43	GO:0003700	DNA binding transcription factor activity
0.33	GO:0005515	protein binding

0.43

GO:0005634

nucleus

tr|T1G079|T1G079_HELRO
Uncharacterized protein
Search

0.57	GO:0007275	multicellular organism development
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.43	GO:0007601	visual perception
0.43	GO:0009653	anatomical structure morphogenesis
0.42	GO:0048468	cell development
0.42	GO:0071695	anatomical structure maturation
0.42	GO:0060021	palate development
0.41	GO:0006366	transcription by RNA polymerase II

0.64	GO:0043565	sequence-specific DNA binding
0.44	GO:0003700	DNA binding transcription factor activity
0.43	GO:0071837	HMG box domain binding
0.42	GO:0044212	transcription regulatory region DNA binding
0.39	GO:0046982	protein heterodimerization activity
0.39	GO:0003690	double-stranded DNA binding
0.38	GO:0003682	chromatin binding
0.33	GO:0016208	AMP binding
0.33	GO:0003987	acetate-CoA ligase activity
0.32	GO:0005524	ATP binding

0.61	GO:0005634	nucleus
0.39	GO:0005667	transcription factor complex
0.36	GO:0030424	axon
0.35	GO:0045202	synapse
0.30	GO:0016020	membrane

0.33

EC:6.2.1.1

GO:0003987

tr|T1G080|T1G080_HELRO
Uncharacterized protein
Search

DCPS

0.88	Scavenger mRNA-decapping enzyme DcpS

0.84	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA
0.41	GO:0036245	cellular response to menadione
0.39	GO:0045292	mRNA cis splicing, via spliceosome
0.39	GO:0043069	negative regulation of programmed cell death
0.36	GO:0009408	response to heat
0.35	GO:0006379	mRNA cleavage
0.34	GO:0006790	sulfur compound metabolic process
0.33	GO:0006163	purine nucleotide metabolic process
0.33	GO:0009259	ribonucleotide metabolic process
0.33	GO:0045454	cell redox homeostasis

0.51	GO:0016787	hydrolase activity
0.50	GO:0000340	RNA 7-methylguanosine cap binding
0.37	GO:0004780	sulfate adenylyltransferase (ADP) activity
0.34	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.34	GO:0008270	zinc ion binding
0.32	GO:0003677	DNA binding

0.44	GO:0000932	P-body
0.41	GO:0005634	nucleus
0.37	GO:0005829	cytosol
0.37	GO:0031974	membrane-enclosed lumen
0.36	GO:0005739	mitochondrion
0.35	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.51	EC:3	GO:0016787
0.37	KEGG:R00530	GO:0004780

tr|T1G081|T1G081_HELRO
Uncharacterized protein
Search

0.54	GO:0032259	methylation
0.52	GO:0031056	regulation of histone modification
0.50	GO:0008345	larval locomotory behavior
0.49	GO:0048513	animal organ development
0.48	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
0.47	GO:1905269	positive regulation of chromatin organization
0.47	GO:0002446	neutrophil mediated immunity
0.46	GO:0042119	neutrophil activation
0.46	GO:0072359	circulatory system development
0.46	GO:0034101	erythrocyte homeostasis

0.52	GO:0008168	methyltransferase activity
0.49	GO:0046872	metal ion binding
0.47	GO:0035064	methylated histone binding
0.43	GO:0019899	enzyme binding

0.47	GO:0035327	transcriptionally active chromatin
0.45	GO:0016593	Cdc73/Paf1 complex
0.30	GO:0016020	membrane

0.52

GO:0008168

tr|T1G082|T1G082_HELRO
Uncharacterized protein
Search

0.62	GO:0007219	Notch signaling pathway
0.59	GO:0007275	multicellular organism development
0.57	GO:0030154	cell differentiation
0.51	GO:0007220	Notch receptor processing
0.51	GO:0009888	tissue development
0.50	GO:0050793	regulation of developmental process
0.48	GO:0061061	muscle structure development
0.48	GO:0097150	neuronal stem cell population maintenance
0.47	GO:0032495	response to muramyl dipeptide
0.47	GO:0002456	T cell mediated immunity

0.70	GO:0005509	calcium ion binding
0.60	GO:0005112	Notch binding
0.43	GO:0005543	phospholipid binding
0.42	GO:0004872	receptor activity
0.35	GO:0098772	molecular function regulator
0.35	GO:0019899	enzyme binding
0.34	GO:0030276	clathrin binding
0.34	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.34	GO:0045296	cadherin binding
0.34	GO:0031490	chromatin DNA binding

0.48	GO:0043025	neuronal cell body
0.48	GO:0030425	dendrite
0.47	GO:0005769	early endosome
0.45	GO:0016324	apical plasma membrane
0.45	GO:0005912	adherens junction
0.36	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex
0.36	GO:0043235	receptor complex
0.34	GO:0005634	nucleus
0.34	GO:0005902	microvillus
0.34	GO:0005576	extracellular region

0.33

GO:0004713

tr|T1G083|T1G083_HELRO
Uncharacterized protein
Search

0.78	GO:0070098	chemokine-mediated signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.67	GO:0006935	chemotaxis
0.52	GO:0007155	cell adhesion
0.42	GO:0002282	microglial cell activation involved in immune response
0.41	GO:1905517	macrophage migration
0.41	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
0.41	GO:0021795	cerebral cortex cell migration
0.40	GO:0016525	negative regulation of angiogenesis
0.37	GO:0009612	response to mechanical stimulus

0.79	GO:0004950	chemokine receptor activity
0.51	GO:0019960	C-X3-C chemokine binding
0.43	GO:0004983	neuropeptide Y receptor activity
0.38	GO:0004947	bradykinin receptor activity
0.35	GO:0005044	scavenger receptor activity
0.34	GO:0070001	aspartic-type peptidase activity
0.34	GO:0004175	endopeptidase activity
0.33	GO:0003676	nucleic acid binding

0.43	GO:0005654	nucleoplasm
0.36	GO:0032809	neuronal cell body membrane
0.35	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0043005	neuron projection
0.34	GO:0005887	integral component of plasma membrane

tr|T1G084|T1G084_HELRO
Uncharacterized protein
Search

0.51	GO:0010991	negative regulation of SMAD protein complex assembly
0.51	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
0.50	GO:0010719	negative regulation of epithelial to mesenchymal transition
0.49	GO:0090288	negative regulation of cellular response to growth factor stimulus
0.48	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
0.48	GO:0030336	negative regulation of cell migration
0.39	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation
0.39	GO:0140058	neuron projection arborization
0.39	GO:1904447	folic acid import across plasma membrane
0.39	GO:0006898	receptor-mediated endocytosis

0.56	GO:0005509	calcium ion binding
0.50	GO:0070412	R-SMAD binding
0.38	GO:0030229	very-low-density lipoprotein particle receptor activity
0.37	GO:0004252	serine-type endopeptidase activity
0.33	GO:0004672	protein kinase activity

0.48	GO:0005794	Golgi apparatus
0.44	GO:0005654	nucleoplasm
0.39	GO:0043235	receptor complex
0.38	GO:0005768	endosome
0.38	GO:0031526	brush border membrane
0.37	GO:0098805	whole membrane
0.37	GO:0009897	external side of plasma membrane
0.37	GO:0016324	apical plasma membrane
0.37	GO:0030139	endocytic vesicle
0.37	GO:0030425	dendrite

0.37

GO:0004252

tr|T1G085|T1G085_HELRO
Uncharacterized protein
Search

CNOT9

0.82	Cell differentiation protein RCD1

0.75	GO:0006402	mRNA catabolic process
0.55	GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
0.53	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
0.51	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
0.50	GO:0033138	positive regulation of peptidyl-serine phosphorylation
0.47	GO:0019221	cytokine-mediated signaling pathway
0.44	GO:0017148	negative regulation of translation
0.41	GO:0031047	gene silencing by RNA
0.36	GO:0006351	transcription, DNA-templated
0.36	GO:0007340	acrosome reaction

0.51	GO:0005154	epidermal growth factor receptor binding
0.47	GO:0019900	kinase binding
0.47	GO:0019904	protein domain specific binding
0.46	GO:0042803	protein homodimerization activity
0.36	GO:0004435	phosphatidylinositol phospholipase C activity
0.34	GO:0005509	calcium ion binding
0.34	GO:0004871	signal transducer activity

0.82	GO:0030014	CCR4-NOT complex
0.52	GO:0000932	P-body
0.37	GO:0005634	nucleus
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.36	EC:3.1.4.11	GO:0004435
0.36	KEGG:R03435	GO:0004435

tr|T1G086|T1G086_HELRO
Uncharacterized protein
Search

MYD88

0.58	Myeloid differentiation primary response protein MyD88

0.63	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.63	GO:0002755	MyD88-dependent toll-like receptor signaling pathway
0.61	GO:0006954	inflammatory response

0.69

GO:0070976

TIR domain binding

0.42	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1G087|T1G087_HELRO
Uncharacterized protein
Search

0.79	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.46	GO:0007010	cytoskeleton organization
0.44	GO:0007299	ovarian follicle cell-cell adhesion
0.44	GO:0032989	cellular component morphogenesis
0.44	GO:0060250	germ-line stem-cell niche homeostasis
0.44	GO:0030536	larval feeding behavior
0.43	GO:0007017	microtubule-based process
0.43	GO:0007304	chorion-containing eggshell formation
0.42	GO:0007259	JAK-STAT cascade
0.42	GO:0007162	negative regulation of cell adhesion

0.69	GO:0019899	enzyme binding
0.42	GO:0098772	molecular function regulator
0.42	GO:0048487	beta-tubulin binding

0.61	GO:0005634	nucleus
0.49	GO:0005737	cytoplasm
0.46	GO:0015630	microtubule cytoskeleton
0.45	GO:0044430	cytoskeletal part
0.39	GO:0099512	supramolecular fiber
0.37	GO:0043234	protein complex
0.36	GO:0005886	plasma membrane

tr|T1G088|T1G088_HELRO
Uncharacterized protein
Search

0.10	Putative Segment polarity protein dishevelled DVL-3 (Fragment)

0.77	GO:0016055	Wnt signaling pathway
0.62	GO:0035556	intracellular signal transduction
0.46	GO:0090163	establishment of epithelial cell planar polarity
0.45	GO:0048076	regulation of compound eye pigmentation
0.45	GO:0016201	synaptic target inhibition
0.45	GO:0035309	wing and notum subfield formation
0.45	GO:0016348	imaginal disc-derived leg joint morphogenesis
0.44	GO:0001737	establishment of imaginal disc-derived wing hair orientation
0.44	GO:1902669	positive regulation of axon guidance
0.44	GO:0035159	regulation of tube length, open tracheal system

0.44	GO:0070300	phosphatidic acid binding
0.44	GO:0030159	receptor signaling complex scaffold activity
0.44	GO:0005112	Notch binding
0.41	GO:0019904	protein domain specific binding
0.37	GO:0005109	frizzled binding

0.45	GO:0005622	intracellular
0.42	GO:0045177	apical part of cell
0.36	GO:0005886	plasma membrane
0.35	GO:0005576	extracellular region
0.32	GO:0043227	membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

tr|T1G089|T1G089_HELRO
Uncharacterized protein
Search

tr|T1G090|T1G090_HELRO
Uncharacterized protein
Search

RPL37A

0.61	Ribosomal protein rpl37a

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.36	GO:0000733	DNA strand renaturation
0.34	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0006334	nucleosome assembly
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.33	GO:0006281	DNA repair
0.33	GO:0019083	viral transcription

0.64	GO:0003735	structural constituent of ribosome
0.36	GO:0036310	annealing helicase activity
0.35	GO:0046872	metal ion binding
0.33	GO:0070180	large ribosomal subunit rRNA binding
0.33	GO:0005515	protein binding
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003677	DNA binding

0.61	GO:0005840	ribosome
0.35	GO:0005925	focal adhesion
0.35	GO:0070062	extracellular exosome
0.34	GO:0044445	cytosolic part
0.34	GO:0044446	intracellular organelle part
0.34	GO:0044815	DNA packaging complex
0.33	GO:0032993	protein-DNA complex
0.33	GO:0005634	nucleus
0.33	GO:0005694	chromosome

tr|T1G091|T1G091_HELRO
Uncharacterized protein
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ZNF593

0.50	Zinc finger domain-containing protein (Fragment)

0.50	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
0.46	GO:0000055	ribosomal large subunit export from nucleus
0.46	GO:0045944	positive regulation of transcription by RNA polymerase II
0.43	GO:0009245	lipid A biosynthetic process
0.33	GO:0006351	transcription, DNA-templated

0.60	GO:0008270	zinc ion binding
0.50	GO:0003676	nucleic acid binding
0.49	GO:0000035	acyl binding
0.45	GO:0000036	acyl carrier activity
0.45	GO:0043023	ribosomal large subunit binding
0.44	GO:0031177	phosphopantetheine binding
0.33	GO:0005515	protein binding

0.46	GO:0030687	preribosome, large subunit precursor
0.45	GO:0005730	nucleolus
0.42	GO:0005829	cytosol

tr|T1G092|T1G092_HELRO
Uncharacterized protein
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0.11	Sodium/hydrogen exchanger (Fragment)

0.79	GO:0006885	regulation of pH
0.77	GO:0035725	sodium ion transmembrane transport
0.62	GO:1902600	hydrogen ion transmembrane transport
0.38	GO:1904480	positive regulation of intestinal absorption
0.37	GO:0010877	lipid transport involved in lipid storage
0.37	GO:0030004	cellular monovalent inorganic cation homeostasis
0.37	GO:0030421	defecation
0.37	GO:1904729	regulation of intestinal lipid absorption
0.37	GO:0045989	positive regulation of striated muscle contraction
0.37	GO:0032370	positive regulation of lipid transport

0.81	GO:0015385	sodium:proton antiporter activity
0.36	GO:0015386	potassium:proton antiporter activity

0.36	GO:0016323	basolateral plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1G093|T1G093_HELRO
Uncharacterized protein
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0.51	Junctophilin-1

0.50	GO:0007517	muscle organ development
0.40	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
0.39	GO:0060402	calcium ion transport into cytosol
0.39	GO:0051050	positive regulation of transport
0.38	GO:1901074	regulation of engulfment of apoptotic cell
0.38	GO:1905155	positive regulation of membrane invagination
0.38	GO:0050850	positive regulation of calcium-mediated signaling
0.37	GO:0055024	regulation of cardiac muscle tissue development
0.37	GO:0051283	negative regulation of sequestering of calcium ion
0.37	GO:0032846	positive regulation of homeostatic process

0.52	GO:0008307	structural constituent of muscle
0.38	GO:0010314	phosphatidylinositol-5-phosphate binding
0.38	GO:0070300	phosphatidic acid binding
0.38	GO:0001786	phosphatidylserine binding
0.38	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.37	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding
0.37	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.37	GO:0015278	calcium-release channel activity
0.37	GO:0070273	phosphatidylinositol-4-phosphate binding
0.37	GO:0032266	phosphatidylinositol-3-phosphate binding

0.78	GO:0030314	junctional membrane complex
0.55	GO:0014701	junctional sarcoplasmic reticulum membrane
0.52	GO:0030018	Z disc
0.45	GO:0005654	nucleoplasm
0.40	GO:0005886	plasma membrane
0.33	GO:0034708	methyltransferase complex
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0036459

tr|T1G094|T1G094_HELRO
Uncharacterized protein
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PRKX

0.70	cAMP-dependent protein kinase catalytic subunit alpha

0.63	GO:0006468	protein phosphorylation
0.47	GO:0060562	epithelial tube morphogenesis
0.47	GO:0001935	endothelial cell proliferation
0.47	GO:2000696	regulation of epithelial cell differentiation involved in kidney development
0.46	GO:0009887	animal organ morphogenesis
0.46	GO:0043542	endothelial cell migration
0.45	GO:0001525	angiogenesis
0.45	GO:0030099	myeloid cell differentiation
0.45	GO:0018209	peptidyl-serine modification
0.45	GO:0001822	kidney development

0.67	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0060089	molecular transducer activity
0.33	GO:0004828	serine-tRNA ligase activity
0.33	GO:0005515	protein binding
0.32	GO:0005057	signal transducer activity, downstream of receptor
0.32	GO:0008374	O-acyltransferase activity

0.39	GO:0005634	nucleus
0.36	GO:0005737	cytoplasm
0.34	GO:0005952	cAMP-dependent protein kinase complex
0.32	GO:0072686	mitotic spindle
0.31	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.67