Queries 1001 to 2000

GO:0016740

tr|T1EFU2|T1EFU2_HELRO
Uncharacterized protein
Search

MRPL22

0.79	Large subunit ribosomal protein L22

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.34	GO:0043624	cellular protein complex disassembly
0.33	GO:0042254	ribosome biogenesis
0.32	GO:0043039	tRNA aminoacylation

0.64	GO:0003735	structural constituent of ribosome
0.34	GO:0003723	RNA binding
0.33	GO:0004814	arginine-tRNA ligase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.70	GO:0015934	large ribosomal subunit
0.49	GO:0005761	mitochondrial ribosome
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0019866	organelle inner membrane
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:6.1.1.19

GO:0004814

tr|T1EFU3|T1EFU3_HELRO
Uncharacterized protein
Search

tr|T1EFU4|T1EFU4_HELRO
Uncharacterized protein
Search

EIF2D

0.48	Eukaryotic translation initiation factor 2D

0.71	GO:0006413	translational initiation
0.54	GO:0075522	IRES-dependent viral translational initiation
0.53	GO:0002181	cytoplasmic translation
0.52	GO:0032790	ribosome disassembly
0.51	GO:0022618	ribonucleoprotein complex assembly
0.33	GO:0006364	rRNA processing

0.72

GO:0003743

translation initiation factor activity

0.54	GO:0022627	cytosolic small ribosomal subunit
0.49	GO:0016604	nuclear body
0.30	GO:0031224	intrinsic component of membrane

tr|T1EFU5|T1EFU5_HELRO
Uncharacterized protein
Search

0.75	GO:0043087	regulation of GTPase activity
0.72	GO:0051345	positive regulation of hydrolase activity
0.61	GO:0007165	signal transduction
0.50	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
0.48	GO:0016525	negative regulation of angiogenesis
0.47	GO:0008285	negative regulation of cell proliferation
0.46	GO:0043065	positive regulation of apoptotic process
0.37	GO:0046580	negative regulation of Ras protein signal transduction

0.73

GO:0005096

GTPase activator activity

0.37	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane
0.33	GO:0005737	cytoplasm

tr|T1EFU6|T1EFU6_HELRO
Uncharacterized protein
Search

0.40	DEAD box ATP-dependent RNA helicase

0.41	GO:0010501	RNA secondary structure unwinding
0.38	GO:0016071	mRNA metabolic process
0.38	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
0.37	GO:0045893	positive regulation of transcription, DNA-templated
0.36	GO:1990120	messenger ribonucleoprotein complex assembly
0.36	GO:0006401	RNA catabolic process
0.36	GO:0032447	protein urmylation
0.35	GO:0034470	ncRNA processing
0.35	GO:0010629	negative regulation of gene expression
0.35	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA

0.66	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.41	GO:0008186	RNA-dependent ATPase activity
0.37	GO:0140098	catalytic activity, acting on RNA
0.35	GO:0035500	MH2 domain binding
0.35	GO:0070412	R-SMAD binding
0.35	GO:0050681	androgen receptor binding

0.39	GO:0005730	nucleolus
0.35	GO:0071141	SMAD protein complex
0.35	GO:0005737	cytoplasm
0.34	GO:0071013	catalytic step 2 spliceosome
0.30	GO:0016020	membrane

0.34

EC:2.7.7

GO:0016779

tr|T1EFU7|T1EFU7_HELRO
Uncharacterized protein
Search

NNT

0.60	Nadp transhydrogenase

0.60	GO:0015992	proton transport
0.51	GO:0055114	oxidation-reduction process
0.39	GO:0006739	NADP metabolic process
0.32	GO:0098662	inorganic cation transmembrane transport

0.75	GO:0008746	NAD(P)+ transhydrogenase activity
0.38	GO:0050661	NADP binding
0.38	GO:0051287	NAD binding
0.33	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.33	GO:0004497	monooxygenase activity
0.33	GO:0020037	heme binding
0.33	GO:0005506	iron ion binding
0.32	GO:0015078	hydrogen ion transmembrane transporter activity

0.37	GO:0005739	mitochondrion
0.37	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.75	EC:1.6.1	GO:0008746
0.75	KEGG:R00112	GO:0008746

tr|T1EFU8|T1EFU8_HELRO
Uncharacterized protein
Search

TBCK

0.94	TBC domain-containing protein kinase-like protein isoform a

0.62	GO:0006468	protein phosphorylation
0.52	GO:0032006	regulation of TOR signaling
0.52	GO:0008283	cell proliferation
0.49	GO:0030036	actin cytoskeleton organization
0.48	GO:0031338	regulation of vesicle fusion
0.48	GO:0090630	activation of GTPase activity
0.43	GO:0006886	intracellular protein transport

0.63	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0017137	Rab GTPase binding
0.45	GO:0005096	GTPase activator activity

0.53	GO:0030496	midbody
0.52	GO:0072686	mitotic spindle
0.42	GO:0012505	endomembrane system
0.38	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EFU9|T1EFU9_HELRO
Uncharacterized protein
Search

0.78	Dual specificity tyrosine-phosphorylation-regulated kinase

0.71	GO:0046777	protein autophosphorylation
0.58	GO:0018108	peptidyl-tyrosine phosphorylation
0.44	GO:0001706	endoderm formation
0.35	GO:1900244	positive regulation of synaptic vesicle endocytosis
0.35	GO:0035332	positive regulation of hippo signaling
0.35	GO:2000253	positive regulation of feeding behavior
0.35	GO:0045887	positive regulation of synaptic growth at neuromuscular junction
0.35	GO:0008355	olfactory learning
0.34	GO:0007632	visual behavior
0.34	GO:0007623	circadian rhythm

0.72	GO:0004712	protein serine/threonine/tyrosine kinase activity
0.58	GO:0004713	protein tyrosine kinase activity
0.56	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0004252	serine-type endopeptidase activity
0.33	GO:0005515	protein binding
0.32	GO:0008168	methyltransferase activity
0.32	GO:0003723	RNA binding

0.34	GO:0043195	terminal bouton
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.72

EC:2.7.12.1

GO:0004712

tr|T1EFV0|T1EFV0_HELRO
Uncharacterized protein
Search

ASS1

0.45	Argininosuccinate synthetase

0.72	GO:0006526	arginine biosynthetic process
0.60	GO:0000053	argininosuccinate metabolic process
0.58	GO:0000050	urea cycle
0.55	GO:0071499	cellular response to laminar fluid shear stress
0.54	GO:0000052	citrulline metabolic process
0.53	GO:0045429	positive regulation of nitric oxide biosynthetic process
0.52	GO:1903038	negative regulation of leukocyte cell-cell adhesion
0.51	GO:0007623	circadian rhythm
0.51	GO:0006531	aspartate metabolic process
0.36	GO:0071418	cellular response to amine stimulus

0.80	GO:0004055	argininosuccinate synthase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0016597	amino acid binding
0.47	GO:0042802	identical protein binding
0.35	GO:0015643	toxic substance binding
0.34	GO:0005452	inorganic anion exchanger activity
0.34	GO:0003723	RNA binding

0.50	GO:0043209	myelin sheath
0.47	GO:0005829	cytosol
0.42	GO:0005739	mitochondrion
0.36	GO:0070062	extracellular exosome
0.35	GO:0070852	cell body fiber
0.35	GO:0043204	perikaryon
0.34	GO:0005764	lysosome
0.34	GO:0031968	organelle outer membrane
0.34	GO:0005783	endoplasmic reticulum
0.33	GO:0005634	nucleus

0.80

EC:6.3.4.5

GO:0004055

tr|T1EFV1|T1EFV1_HELRO
Uncharacterized protein
Search

0.92	LIM homeobox transcription factor 1-alpha

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:1904948	midbrain dopaminergic neuron differentiation
0.56	GO:0010468	regulation of gene expression
0.56	GO:0021542	dentate gyrus development
0.56	GO:0030902	hindbrain development
0.55	GO:0042048	olfactory behavior
0.54	GO:0007613	memory
0.53	GO:0045665	negative regulation of neuron differentiation
0.53	GO:0007626	locomotory behavior

0.64	GO:0043565	sequence-specific DNA binding
0.53	GO:0046872	metal ion binding
0.52	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.51	GO:0001012	RNA polymerase II regulatory region DNA binding
0.48	GO:0003690	double-stranded DNA binding
0.36	GO:0003707	steroid hormone receptor activity
0.33	GO:0005515	protein binding

0.61

GO:0005634

nucleus

tr|T1EFV2|T1EFV2_HELRO
Uncharacterized protein
Search

0.73

Lamin-C

0.38	GO:0007399	nervous system development
0.38	GO:0048869	cellular developmental process
0.38	GO:0120036	plasma membrane bounded cell projection organization
0.36	GO:0070870	heterochromatin maintenance involved in chromatin silencing
0.36	GO:1905832	positive regulation of spindle assembly
0.36	GO:0007110	meiosis I cytokinesis
0.36	GO:0007430	terminal branching, open tracheal system
0.36	GO:0048137	spermatocyte division
0.36	GO:2000433	positive regulation of cytokinesis, actomyosin contractile ring assembly
0.36	GO:0071763	nuclear membrane organization

0.62	GO:0005198	structural molecule activity
0.37	GO:0019899	enzyme binding
0.34	GO:0005102	receptor binding
0.32	GO:0003677	DNA binding

0.79	GO:0005882	intermediate filament
0.42	GO:0005635	nuclear envelope
0.38	GO:0005652	nuclear lamina
0.36	GO:0070732	spindle envelope
0.36	GO:0016363	nuclear matrix
0.35	GO:0070062	extracellular exosome
0.35	GO:0036338	viral membrane
0.34	GO:0005654	nucleoplasm
0.34	GO:0044444	cytoplasmic part
0.34	GO:0019866	organelle inner membrane

tr|T1EFV3|T1EFV3_HELRO
Uncharacterized protein
Search

CDC16

0.94	Cell division cycle protein 16

0.59	GO:0051301	cell division
0.57	GO:0070979	protein K11-linked ubiquitination
0.44	GO:0000278	mitotic cell cycle
0.36	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:1904667	negative regulation of ubiquitin protein ligase activity
0.35	GO:0031145	anaphase-promoting complex-dependent catabolic process
0.35	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.35	GO:0008283	cell proliferation
0.35	GO:0007088	regulation of mitotic nuclear division
0.34	GO:0022402	cell cycle process

0.34	GO:0005515	protein binding
0.32	GO:0003723	RNA binding

0.54	GO:0005876	spindle microtubule
0.53	GO:0005680	anaphase-promoting complex
0.52	GO:0005813	centrosome
0.39	GO:0005737	cytoplasm
0.34	GO:0005654	nucleoplasm

tr|T1EFV4|T1EFV4_HELRO
Uncharacterized protein
Search

0.70	Prolactin regulatory element binding

0.45	GO:0090113	regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis
0.45	GO:0048209	regulation of vesicle targeting, to, from or within Golgi
0.44	GO:0032527	protein exit from endoplasmic reticulum
0.41	GO:0043547	positive regulation of GTPase activity
0.41	GO:0033043	regulation of organelle organization
0.40	GO:0009306	protein secretion
0.40	GO:0043254	regulation of protein complex assembly

0.49	GO:0005090	Sar guanyl-nucleotide exchange factor activity
0.41	GO:0005096	GTPase activator activity

0.44	GO:0070971	endoplasmic reticulum exit site
0.42	GO:0030176	integral component of endoplasmic reticulum membrane
0.38	GO:0005634	nucleus

tr|T1EFV5|T1EFV5_HELRO
Uncharacterized protein
Search

0.71	Small G protein signaling modulator

0.81	GO:0032483	regulation of Rab protein signal transduction
0.81	GO:0048227	plasma membrane to endosome transport
0.81	GO:0032486	Rap protein signal transduction
0.71	GO:0045732	positive regulation of protein catabolic process
0.71	GO:0043547	positive regulation of GTPase activity
0.62	GO:0031338	regulation of vesicle fusion
0.53	GO:0006886	intracellular protein transport
0.47	GO:0007050	cell cycle arrest
0.43	GO:1902017	regulation of cilium assembly
0.41	GO:0006351	transcription, DNA-templated

0.75	GO:0017137	Rab GTPase binding
0.71	GO:0005096	GTPase activator activity
0.46	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.39	GO:0003676	nucleic acid binding

0.72	GO:0005921	gap junction
0.63	GO:0005829	cytosol
0.51	GO:0012505	endomembrane system
0.30	GO:0016020	membrane

0.46

GO:0003899

tr|T1EFV6|T1EFV6_HELRO
Uncharacterized protein
Search

0.11	Unkempt family zinc finger-like

0.36	GO:0008407	chaeta morphogenesis
0.36	GO:0007476	imaginal disc-derived wing morphogenesis
0.35	GO:0002164	larval development
0.35	GO:0048749	compound eye development
0.35	GO:0050767	regulation of neurogenesis
0.35	GO:0030182	neuron differentiation

0.54	GO:0046872	metal ion binding
0.37	GO:0016874	ligase activity
0.35	GO:0005515	protein binding
0.34	GO:0003723	RNA binding
0.33	GO:0003677	DNA binding

0.32	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.37

GO:0016874

tr|T1EFV7|T1EFV7_HELRO
Uncharacterized protein
Search

0.62	Limb development membrane protein 1

0.42

GO:0006898

receptor-mediated endocytosis

0.40

GO:0004872

receptor activity

0.40

GO:0005887

integral component of plasma membrane

tr|T1EFV8|T1EFV8_HELRO
Uncharacterized protein
Search

0.56	GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
0.52	GO:0061014	positive regulation of mRNA catabolic process
0.51	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
0.50	GO:0006351	transcription, DNA-templated
0.49	GO:0008284	positive regulation of cell proliferation
0.45	GO:0017148	negative regulation of translation
0.37	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
0.35	GO:0031047	gene silencing by RNA
0.35	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
0.34	GO:0016441	posttranscriptional gene silencing

0.56	GO:0004535	poly(A)-specific ribonuclease activity
0.51	GO:0003676	nucleic acid binding
0.34	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding
0.33	GO:0016740	transferase activity
0.33	GO:0003700	DNA binding transcription factor activity

0.54	GO:0030014	CCR4-NOT complex
0.47	GO:0000932	P-body
0.34	GO:0005634	nucleus
0.33	GO:0005829	cytosol

0.56

EC:3.1.13.4

GO:0004535

tr|T1EFV9|T1EFV9_HELRO
DNA ligase
Search

LIG3

0.47	DNA ligase

0.80	GO:0051103	DNA ligation involved in DNA repair
0.67	GO:0071897	DNA biosynthetic process
0.66	GO:0006260	DNA replication
0.65	GO:0006310	DNA recombination
0.58	GO:0090298	negative regulation of mitochondrial DNA replication
0.52	GO:0006302	double-strand break repair
0.49	GO:0006284	base-excision repair
0.47	GO:0022616	DNA strand elongation
0.44	GO:0000726	non-recombinational repair
0.39	GO:0043504	mitochondrial DNA repair

0.79	GO:0003910	DNA ligase (ATP) activity
0.63	GO:0008270	zinc ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.55	GO:0003677	DNA binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding

0.47	GO:0005654	nucleoplasm
0.41	GO:0005739	mitochondrion
0.41	GO:0070421	DNA ligase III-XRCC1 complex
0.37	GO:0000795	synaptonemal complex
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:6.5.1.1

GO:0003910

tr|T1EFW0|T1EFW0_HELRO
Uncharacterized protein
Search

0.51	CCR4-NOT transcription complex subunit 3

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.39	GO:0034249	negative regulation of cellular amide metabolic process
0.39	GO:0006401	RNA catabolic process
0.38	GO:0016071	mRNA metabolic process
0.38	GO:0032269	negative regulation of cellular protein metabolic process
0.38	GO:0010558	negative regulation of macromolecule biosynthetic process
0.38	GO:0031327	negative regulation of cellular biosynthetic process
0.35	GO:0065009	regulation of molecular function

0.37	GO:0005246	calcium channel regulator activity
0.33	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
0.32	GO:0016307	phosphatidylinositol phosphate kinase activity
0.32	GO:0017137	Rab GTPase binding
0.32	GO:0004222	metalloendopeptidase activity
0.32	GO:0005096	GTPase activator activity
0.32	GO:0004527	exonuclease activity
0.32	GO:0008270	zinc ion binding
0.32	GO:0004519	endonuclease activity
0.32	GO:0008168	methyltransferase activity

0.76	GO:0030015	CCR4-NOT core complex
0.61	GO:0005634	nucleus
0.40	GO:0000932	P-body
0.32	GO:0012505	endomembrane system
0.30	GO:0016020	membrane

0.33	EC:3.1.3.36	GO:0004439
0.33	KEGG:R04404	GO:0004439

tr|T1EFW1|T1EFW1_HELRO
Uncharacterized protein
Search

MCF2L

0.47	Guanine nucleotide exchange factor DBS

0.78	GO:0035023	regulation of Rho protein signal transduction
0.66	GO:0065009	regulation of molecular function
0.60	GO:0035556	intracellular signal transduction
0.45	GO:0007412	axon target recognition
0.45	GO:0045887	positive regulation of synaptic growth at neuromuscular junction
0.44	GO:0016319	mushroom body development
0.44	GO:0007480	imaginal disc-derived leg morphogenesis
0.44	GO:0048675	axon extension
0.44	GO:0046579	positive regulation of Ras protein signal transduction
0.43	GO:0071772	response to BMP

0.78	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.35	GO:0005543	phospholipid binding
0.34	GO:0005057	signal transducer activity, downstream of receptor
0.33	GO:0046872	metal ion binding
0.33	GO:0016740	transferase activity

0.44	GO:0005622	intracellular
0.43	GO:0030426	growth cone
0.42	GO:0030424	axon
0.42	GO:0019897	extrinsic component of plasma membrane
0.41	GO:0009898	cytoplasmic side of plasma membrane
0.35	GO:0043233	organelle lumen
0.33	GO:0043227	membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

0.33

GO:0016740

tr|T1EFW2|T1EFW2_HELRO
Uncharacterized protein
Search

0.48	Disintegrin and metalloproteinase domain-containing protein 10

0.64	GO:0007229	integrin-mediated signaling pathway
0.61	GO:0006508	proteolysis
0.44	GO:0035386	regulation of Roundabout signaling pathway
0.43	GO:0061320	pericardial nephrocyte differentiation
0.43	GO:0007400	neuroblast fate determination
0.42	GO:0007220	Notch receptor processing
0.42	GO:0007419	ventral cord development
0.42	GO:0048542	lymph gland development
0.42	GO:0008347	glial cell migration
0.42	GO:0007298	border follicle cell migration

0.70	GO:0004222	metalloendopeptidase activity
0.54	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.40	GO:0098595	perivitelline space
0.36	GO:0030659	cytoplasmic vesicle membrane
0.34	GO:0016323	basolateral plasma membrane
0.30	GO:0016021	integral component of membrane

0.70

GO:0004222

tr|T1EFW3|T1EFW3_HELRO
Uncharacterized protein
Search

IPO7

0.86	Putative nuclear transport receptor ranbp7/ranbp8 importin beta superfamily

0.69	GO:0006886	intracellular protein transport
0.50	GO:0006606	protein import into nucleus
0.45	GO:0045087	innate immune response
0.39	GO:0007165	signal transduction
0.34	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
0.33	GO:0016032	viral process
0.32	GO:0055085	transmembrane transport

0.78	GO:0008536	Ran GTPase binding
0.47	GO:0046332	SMAD binding
0.45	GO:0042393	histone binding
0.42	GO:0008565	protein transporter activity
0.33	GO:0030695	GTPase regulator activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0042626	ATPase activity, coupled to transmembrane movement of substances

0.58	GO:0005634	nucleus
0.45	GO:0005829	cytosol
0.41	GO:0031974	membrane-enclosed lumen
0.41	GO:0012505	endomembrane system
0.41	GO:0044446	intracellular organelle part
0.39	GO:0031975	envelope
0.33	GO:0005887	integral component of plasma membrane
0.32	GO:0043234	protein complex

tr|T1EFW4|T1EFW4_HELRO
Uncharacterized protein
Search

0.74	GO:0016055	Wnt signaling pathway
0.70	GO:0007275	multicellular organism development
0.60	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation
0.60	GO:0030510	regulation of BMP signaling pathway
0.60	GO:0061185	negative regulation of dermatome development
0.59	GO:0035412	regulation of catenin import into nucleus
0.59	GO:0042662	negative regulation of mesodermal cell fate specification
0.59	GO:0043508	negative regulation of JUN kinase activity
0.58	GO:0090178	regulation of establishment of planar polarity involved in neural tube closure
0.58	GO:0071481	cellular response to X-ray

0.59	GO:0017147	Wnt-protein binding
0.57	GO:0061133	endopeptidase activator activity
0.51	GO:0048018	receptor ligand activity
0.49	GO:0042813	Wnt-activated receptor activity
0.44	GO:0004930	G-protein coupled receptor activity
0.37	GO:0001968	fibronectin binding
0.36	GO:0005178	integrin binding
0.36	GO:0005109	frizzled binding
0.35	GO:0008201	heparin binding
0.35	GO:0004197	cysteine-type endopeptidase activity

0.64	GO:0005576	extracellular region
0.35	GO:0009986	cell surface
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.35

EC:3.4.22

GO:0004197

tr|T1EFW5|T1EFW5_HELRO
Uncharacterized protein
Search

0.66	GO:0051492	regulation of stress fiber assembly
0.64	GO:0007015	actin filament organization
0.47	GO:0035070	salivary gland histolysis
0.47	GO:0060439	trachea morphogenesis
0.47	GO:0090505	epiboly involved in wound healing
0.47	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
0.47	GO:0010623	programmed cell death involved in cell development
0.47	GO:0046716	muscle cell cellular homeostasis
0.46	GO:0032233	positive regulation of actin filament bundle assembly
0.46	GO:0007476	imaginal disc-derived wing morphogenesis

0.36

GO:0000062

fatty-acyl-CoA binding

0.44	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0005634	nucleus
0.33	GO:0031974	membrane-enclosed lumen
0.33	GO:0043234	protein complex
0.32	GO:0044446	intracellular organelle part

tr|T1EFW6|T1EFW6_HELRO
Uncharacterized protein
Search

PEBP1

0.58	Phosphatidylethanolamine-binding protein 1

0.54	GO:0007264	small GTPase mediated signal transduction
0.52	GO:0065009	regulation of molecular function
0.46	GO:0045861	negative regulation of proteolysis
0.40	GO:0006413	translational initiation
0.39	GO:0000165	MAPK cascade
0.37	GO:0015074	DNA integration
0.35	GO:0006508	proteolysis

0.66	GO:0019899	enzyme binding
0.54	GO:0098772	molecular function regulator
0.45	GO:0008289	lipid binding
0.40	GO:0003743	translation initiation factor activity
0.40	GO:0032559	adenyl ribonucleotide binding
0.39	GO:0008144	drug binding
0.39	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0070001	aspartic-type peptidase activity
0.36	GO:0004175	endopeptidase activity
0.35	GO:0016887	ATPase activity

0.39	GO:0005622	intracellular
0.39	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.35

GO:0016887

tr|T1EFW7|T1EFW7_HELRO
Uncharacterized protein
Search

tr|T1EFW8|T1EFW8_HELRO
DNA helicase
Search

MCM5

0.43	DNA replication licensing factor MCM5

0.75	GO:0006270	DNA replication initiation
0.70	GO:0032392	DNA geometric change
0.40	GO:0043009	chordate embryonic development
0.40	GO:0007049	cell cycle
0.40	GO:0043066	negative regulation of apoptotic process
0.37	GO:0035825	homologous recombination
0.36	GO:0000280	nuclear division
0.36	GO:0030261	chromosome condensation
0.36	GO:0051301	cell division
0.36	GO:0007059	chromosome segregation

0.78	GO:0003688	DNA replication origin binding
0.77	GO:0003682	chromatin binding
0.70	GO:0003678	DNA helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0004392	heme oxygenase (decyclizing) activity
0.34	GO:0005515	protein binding
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding

0.79	GO:0042555	MCM complex
0.61	GO:0005634	nucleus
0.45	GO:0031974	membrane-enclosed lumen
0.41	GO:0044446	intracellular organelle part
0.35	GO:0005829	cytosol
0.35	GO:0005694	chromosome
0.30	GO:0016020	membrane

0.34

EC:1.14.99.3

GO:0004392

tr|T1EFW9|T1EFW9_HELRO
Uncharacterized protein
Search

tr|T1EFX0|T1EFX0_HELRO
Uncharacterized protein
Search

tr|T1EFX1|T1EFX1_HELRO
Uncharacterized protein
Search

0.39	Glutamyl-tRNA synthetase

0.77	GO:0006424	glutamyl-tRNA aminoacylation
0.47	GO:0032543	mitochondrial translation
0.32	GO:0006508	proteolysis
0.32	GO:0055114	oxidation-reduction process

0.78	GO:0004818	glutamate-tRNA ligase activity
0.67	GO:0000049	tRNA binding
0.63	GO:0008270	zinc ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0004252	serine-type endopeptidase activity
0.32	GO:0016491	oxidoreductase activity

0.49	GO:0005737	cytoplasm
0.39	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016020	membrane

0.78

EC:6.1.1.17

GO:0004818

tr|T1EFX2|T1EFX2_HELRO
Uncharacterized protein
Search

0.46	E3 ubiquitin-protein ligase UHRF2

0.58	GO:0016874	ligase activity
0.53	GO:0046872	metal ion binding

0.61

GO:0005634

nucleus

0.58

GO:0016874

tr|T1EFX3|T1EFX3_HELRO
Uncharacterized protein
Search

0.40	Glucosamine-fructose-6-phosphate aminotransferase

0.60	GO:1901137	carbohydrate derivative biosynthetic process
0.38	GO:0006047	UDP-N-acetylglucosamine metabolic process
0.37	GO:0006002	fructose 6-phosphate metabolic process
0.37	GO:0043413	macromolecule glycosylation
0.37	GO:0009100	glycoprotein metabolic process
0.35	GO:0006464	cellular protein modification process
0.34	GO:1901566	organonitrogen compound biosynthetic process
0.34	GO:0009059	macromolecule biosynthetic process
0.33	GO:0044249	cellular biosynthetic process
0.33	GO:0006886	intracellular protein transport

0.76	GO:0004360	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
0.54	GO:0097367	carbohydrate derivative binding
0.34	GO:0004044	amidophosphoribosyltransferase activity

0.31	GO:0005622	intracellular
0.30	GO:0031224	intrinsic component of membrane

0.76	EC:2.6.1.16	GO:0004360
0.76	KEGG:R00768	GO:0004360

tr|T1EFX4|T1EFX4_HELRO
Uncharacterized protein
Search

0.10	Large neutral amino acids transporter small subunit 1

0.59	GO:0006865	amino acid transport
0.55	GO:0055085	transmembrane transport
0.46	GO:1901998	toxin transport
0.45	GO:0015695	organic cation transport
0.35	GO:0014005	microglia development
0.34	GO:0015837	amine transport
0.34	GO:0050900	leukocyte migration
0.34	GO:0042221	response to chemical
0.33	GO:0055065	metal ion homeostasis
0.33	GO:0006468	protein phosphorylation

0.57	GO:0022857	transmembrane transporter activity
0.38	GO:0042605	peptide antigen binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0005515	protein binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003700	DNA binding transcription factor activity
0.31	GO:0003676	nucleic acid binding

0.43	GO:0005886	plasma membrane
0.40	GO:0005829	cytosol
0.38	GO:0043227	membrane-bounded organelle
0.36	GO:0043229	intracellular organelle
0.35	GO:0043230	extracellular organelle
0.34	GO:0005615	extracellular space
0.34	GO:0045177	apical part of cell
0.30	GO:0016021	integral component of membrane

tr|T1EFX5|T1EFX5_HELRO
Uncharacterized protein
Search

0.88	Prohibitins and stomatins of the pid superfamily

0.35	GO:1990046	stress-induced mitochondrial fusion
0.35	GO:1900210	positive regulation of cardiolipin metabolic process
0.35	GO:0090297	positive regulation of mitochondrial DNA replication
0.35	GO:0032623	interleukin-2 production
0.35	GO:0010918	positive regulation of mitochondrial membrane potential
0.35	GO:0042776	mitochondrial ATP synthesis coupled proton transport
0.35	GO:0006851	mitochondrial calcium ion transmembrane transport
0.35	GO:0035710	CD4-positive, alpha-beta T cell activation
0.34	GO:0050852	T cell receptor signaling pathway
0.34	GO:0034982	mitochondrial protein processing

0.35	GO:1901612	cardiolipin binding
0.34	GO:0051020	GTPase binding

0.36	GO:0005739	mitochondrion
0.35	GO:0042101	T cell receptor complex
0.34	GO:0001772	immunological synapse
0.34	GO:0008180	COP9 signalosome
0.34	GO:0045121	membrane raft
0.34	GO:0031970	organelle envelope lumen
0.34	GO:0019897	extrinsic component of plasma membrane
0.34	GO:0015629	actin cytoskeleton
0.33	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

tr|T1EFX6|T1EFX6_HELRO
Uncharacterized protein
Search

ARRB2

0.66	Nonvisual arrestin

0.61	GO:0007165	signal transduction
0.45	GO:0002031	G-protein coupled receptor internalization
0.45	GO:0002092	positive regulation of receptor internalization
0.45	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin
0.45	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity
0.45	GO:0032226	positive regulation of synaptic transmission, dopaminergic
0.44	GO:0032691	negative regulation of interleukin-1 beta production
0.44	GO:0032695	negative regulation of interleukin-12 production
0.44	GO:2000727	positive regulation of cardiac muscle cell differentiation
0.44	GO:0060765	regulation of androgen receptor signaling pathway

0.45	GO:0031701	angiotensin receptor binding
0.45	GO:0043422	protein kinase B binding
0.42	GO:0032947	protein complex scaffold activity
0.42	GO:0031625	ubiquitin protein ligase binding
0.35	GO:0031859	platelet activating factor receptor binding
0.35	GO:0031691	alpha-1A adrenergic receptor binding
0.35	GO:0031692	alpha-1B adrenergic receptor binding
0.35	GO:0031762	follicle-stimulating hormone receptor binding
0.35	GO:0031826	type 2A serotonin receptor binding
0.35	GO:0031748	D1 dopamine receptor binding

0.43	GO:0030139	endocytic vesicle
0.38	GO:0005634	nucleus
0.37	GO:0005886	plasma membrane
0.37	GO:0005905	clathrin-coated pit
0.35	GO:0030425	dendrite
0.34	GO:0044309	neuron spine
0.34	GO:0043204	perikaryon
0.34	GO:0014069	postsynaptic density
0.33	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

tr|T1EFX7|T1EFX7_HELRO
Uncharacterized protein
Search

DKC1

0.61	rRNA pseudouridine synthase

0.72	GO:0001522	pseudouridine synthesis
0.63	GO:0006396	RNA processing
0.54	GO:0033979	box H/ACA snoRNA metabolic process
0.53	GO:0040031	snRNA modification
0.50	GO:0016556	mRNA modification
0.46	GO:0016072	rRNA metabolic process
0.45	GO:0042254	ribosome biogenesis
0.36	GO:0060216	definitive hemopoiesis
0.34	GO:0006904	vesicle docking involved in exocytosis

0.72	GO:0009982	pseudouridine synthase activity
0.59	GO:0003723	RNA binding
0.32	GO:0016787	hydrolase activity

0.57	GO:0019013	viral nucleocapsid
0.53	GO:0030529	intracellular ribonucleoprotein complex
0.49	GO:0044452	nucleolar part
0.43	GO:1902494	catalytic complex
0.34	GO:0000145	exocyst

0.72

EC:5.4.99.12

GO:0009982

tr|T1EFX8|T1EFX8_HELRO
alpha-1,2-Mannosidase
Search

0.47	alpha-1,2-Mannosidase

0.47	GO:0035977	protein deglycosylation involved in glycoprotein catabolic process
0.46	GO:0097466	ubiquitin-dependent glycoprotein ERAD pathway
0.45	GO:0006491	N-glycan processing
0.43	GO:0036509	trimming of terminal mannose on B branch
0.43	GO:0035010	encapsulation of foreign target

0.82	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
0.70	GO:0005509	calcium ion binding
0.35	GO:0070569	uridylyltransferase activity

0.45	GO:0005783	endoplasmic reticulum
0.42	GO:0000139	Golgi membrane
0.30	GO:0031224	intrinsic component of membrane

0.82	EC:3.2.1.113	GO:0004571
0.82	KEGG:R05982 KEGG:R06722	GO:0004571

tr|T1EFX9|T1EFX9_HELRO
Ubiquitinyl hydrolase 1
Search

USP22

0.58	Ubiquitinyl hydrolase 1

0.73	GO:0016579	protein deubiquitination
0.70	GO:0006511	ubiquitin-dependent protein catabolic process
0.46	GO:0043967	histone H4 acetylation
0.46	GO:0016574	histone ubiquitination
0.45	GO:0045931	positive regulation of mitotic cell cycle
0.43	GO:0045893	positive regulation of transcription, DNA-templated
0.34	GO:2001032	regulation of double-strand break repair via nonhomologous end joining
0.34	GO:0010569	regulation of double-strand break repair via homologous recombination
0.33	GO:0010564	regulation of cell cycle process
0.33	GO:0006412	translation

0.73	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.60	GO:0008270	zinc ion binding
0.47	GO:0010485	H4 histone acetyltransferase activity
0.46	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
0.42	GO:0019899	enzyme binding
0.33	GO:0042393	histone binding
0.33	GO:0003682	chromatin binding
0.33	GO:0003735	structural constituent of ribosome

0.45	GO:0016607	nuclear speck
0.45	GO:0000124	SAGA complex
0.33	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.73

GO:0036459

tr|T1EFY0|T1EFY0_HELRO
Uncharacterized protein
Search

SF3A2

0.47	Splicing factor 3A subunit

0.43	GO:0000245	spliceosomal complex assembly
0.34	GO:0046579	positive regulation of Ras protein signal transduction
0.34	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.33	GO:0043043	peptide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process
0.32	GO:0009059	macromolecule biosynthetic process

0.63	GO:0008270	zinc ion binding
0.51	GO:0003676	nucleic acid binding
0.34	GO:0005199	structural constituent of cell wall
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003735	structural constituent of ribosome

0.61	GO:0005634	nucleus
0.42	GO:0120114	Sm-like protein family complex
0.39	GO:0030529	intracellular ribonucleoprotein complex
0.39	GO:1902494	catalytic complex
0.38	GO:0044446	intracellular organelle part
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.32	GO:0044444	cytoplasmic part

tr|T1EFY1|T1EFY1_HELRO
Uncharacterized protein
Search

0.48	ES1 protein like protein, mitochondrial

0.41	GO:0006541	glutamine metabolic process
0.39	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.37	GO:0006959	humoral immune response
0.36	GO:0006914	autophagy
0.36	GO:0006468	protein phosphorylation
0.35	GO:0006417	regulation of translation
0.33	GO:0055114	oxidation-reduction process

0.51	GO:0016829	lyase activity
0.40	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
0.37	GO:0045182	translation regulator activity
0.37	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003677	DNA binding
0.33	GO:0046872	metal ion binding
0.33	GO:0016491	oxidoreductase activity

0.51	GO:0005739	mitochondrion
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.51

EC:4

GO:0016829

tr|T1EFY2|T1EFY2_HELRO
Uncharacterized protein
Search

0.78	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide

0.81	GO:0048015	phosphatidylinositol-mediated signaling
0.75	GO:0046854	phosphatidylinositol phosphorylation
0.59	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
0.54	GO:0043491	protein kinase B signaling
0.52	GO:1905037	autophagosome organization
0.50	GO:0009267	cellular response to starvation
0.46	GO:0030866	cortical actin cytoskeleton organization
0.44	GO:0016477	cell migration

0.76	GO:0035091	phosphatidylinositol binding
0.60	GO:0016301	kinase activity
0.45	GO:0017137	Rab GTPase binding
0.43	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0016787	hydrolase activity

0.52	GO:0031410	cytoplasmic vesicle
0.47	GO:0005654	nucleoplasm
0.46	GO:0005829	cytosol
0.45	GO:0005942	phosphatidylinositol 3-kinase complex
0.42	GO:0098805	whole membrane
0.42	GO:0098588	bounding membrane of organelle
0.41	GO:0012505	endomembrane system
0.37	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.43

GO:0016773

tr|T1EFY3|T1EFY3_HELRO
Uncharacterized protein
Search

0.10	Erythrocyte membrane protein band 4.1 3

0.71	GO:0007016	cytoskeletal anchoring at plasma membrane
0.67	GO:0001558	regulation of cell growth
0.43	GO:0030866	cortical actin cytoskeleton organization
0.37	GO:0031032	actomyosin structure organization
0.33	GO:0035335	peptidyl-tyrosine dephosphorylation

0.71	GO:0008092	cytoskeletal protein binding
0.56	GO:0005198	structural molecule activity
0.33	GO:0004725	protein tyrosine phosphatase activity

0.69	GO:0005856	cytoskeleton
0.65	GO:0005911	cell-cell junction
0.49	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.33

GO:0004725

tr|T1EFY4|T1EFY4_HELRO
Elongation factor G, mitochondrial
Search

GFM1

0.71	Elongation factor G, mitochondrial

0.81	GO:0070125	mitochondrial translational elongation
0.33	GO:0006468	protein phosphorylation

0.70	GO:0003746	translation elongation factor activity
0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0004672	protein kinase activity
0.33	GO:0005515	protein binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0008144	drug binding

0.58	GO:0005739	mitochondrion
0.38	GO:0005634	nucleus
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part

tr|T1EFY5|T1EFY5_HELRO
Uncharacterized protein
Search

0.10	AAA-domain-containing protein

0.61	GO:1901800	positive regulation of proteasomal protein catabolic process
0.55	GO:0030163	protein catabolic process
0.48	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
0.47	GO:0070651	nonfunctional rRNA decay
0.46	GO:0070682	proteasome regulatory particle assembly
0.46	GO:0043433	negative regulation of DNA binding transcription factor activity
0.46	GO:0051091	positive regulation of DNA binding transcription factor activity
0.45	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
0.44	GO:0006338	chromatin remodeling
0.44	GO:0043632	modification-dependent macromolecule catabolic process

0.62	GO:0036402	proteasome-activating ATPase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0019904	protein domain specific binding
0.41	GO:0008233	peptidase activity
0.37	GO:0017025	TBP-class protein binding
0.34	GO:0003689	DNA clamp loader activity
0.33	GO:0008270	zinc ion binding

0.50	GO:1905369	endopeptidase complex
0.43	GO:0043234	protein complex
0.43	GO:0044445	cytosolic part
0.42	GO:0005634	nucleus
0.40	GO:0030687	preribosome, large subunit precursor
0.38	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part
0.36	GO:0043232	intracellular non-membrane-bounded organelle
0.35	GO:0005739	mitochondrion
0.32	GO:0042579	microbody

0.41

GO:0008233

tr|T1EFY6|T1EFY6_HELRO
Guanylate cyclase
Search

0.57	Guanylate cyclase

0.82	GO:0006182	cGMP biosynthetic process
0.63	GO:0006468	protein phosphorylation
0.63	GO:0035556	intracellular signal transduction
0.43	GO:0060038	cardiac muscle cell proliferation
0.38	GO:0007168	receptor guanylyl cyclase signaling pathway
0.35	GO:0050893	sensory processing
0.35	GO:0018212	peptidyl-tyrosine modification
0.34	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus
0.34	GO:0042048	olfactory behavior
0.34	GO:0042417	dopamine metabolic process

0.82	GO:0004383	guanylate cyclase activity
0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0004016	adenylate cyclase activity
0.38	GO:0016941	natriuretic peptide receptor activity
0.35	GO:0017046	peptide hormone binding
0.33	GO:0019901	protein kinase binding
0.33	GO:0032550	purine ribonucleoside binding

0.45	GO:0005622	intracellular
0.35	GO:0043234	protein complex
0.35	GO:0005886	plasma membrane
0.34	GO:0044297	cell body
0.33	GO:0043005	neuron projection
0.33	GO:0043235	receptor complex
0.30	GO:0016021	integral component of membrane

0.82

EC:4.6.1.2

GO:0004383

tr|T1EFY7|T1EFY7_HELRO
Uncharacterized protein
Search

TMEM259

0.52

Membralin

0.52	GO:1904294	positive regulation of ERAD pathway
0.49	GO:1901215	negative regulation of neuron death
0.48	GO:0034976	response to endoplasmic reticulum stress
0.42	GO:0048190	wing disc dorsal/ventral pattern formation
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression

0.34	GO:0042302	structural constituent of cuticle
0.33	GO:0005515	protein binding

0.45	GO:0005783	endoplasmic reticulum
0.35	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.35	GO:0031984	organelle subcompartment
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

tr|T1EFY8|T1EFY8_HELRO
Innexin
Search

0.37

Innexin

0.59	GO:0006811	ion transport
0.35	GO:0048598	embryonic morphogenesis

0.81	GO:0005921	gap junction
0.56	GO:0005886	plasma membrane
0.32	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

tr|T1EFY9|T1EFY9_HELRO
Uncharacterized protein
Search

0.58	Eukaryotic translation initiation factor 2-alpha kinase 3 (Fragment)

0.70	GO:0006413	translational initiation
0.63	GO:0006468	protein phosphorylation
0.47	GO:0036491	regulation of translation initiation in response to endoplasmic reticulum stress
0.46	GO:0006983	ER overload response
0.46	GO:0010575	positive regulation of vascular endothelial growth factor production
0.46	GO:1902235	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.45	GO:0031018	endocrine pancreas development
0.45	GO:0045943	positive regulation of transcription by RNA polymerase I
0.45	GO:0034198	cellular response to amino acid starvation
0.45	GO:0042149	cellular response to glucose starvation

0.71	GO:0003743	translation initiation factor activity
0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0019903	protein phosphatase binding
0.44	GO:0045182	translation regulator activity
0.42	GO:0042802	identical protein binding
0.39	GO:0003924	GTPase activity
0.39	GO:0032550	purine ribonucleoside binding

0.30

GO:0016020

membrane

tr|T1EFZ0|T1EFZ0_HELRO
Uncharacterized protein
Search

0.48	GO:0006629	lipid metabolic process
0.40	GO:0044248	cellular catabolic process
0.39	GO:1901565	organonitrogen compound catabolic process
0.38	GO:0043603	cellular amide metabolic process
0.38	GO:0030299	intestinal cholesterol absorption
0.36	GO:0018350	protein esterification
0.36	GO:1902652	secondary alcohol metabolic process
0.36	GO:0030157	pancreatic juice secretion
0.36	GO:0046164	alcohol catabolic process
0.36	GO:0097105	presynaptic membrane assembly

0.52	GO:0004104	cholinesterase activity
0.36	GO:0005515	protein binding
0.36	GO:0016298	lipase activity
0.35	GO:0008201	heparin binding
0.34	GO:0005230	extracellular ligand-gated ion channel activity
0.33	GO:0004872	receptor activity

0.36	GO:0005641	nuclear envelope lumen
0.36	GO:0005783	endoplasmic reticulum
0.35	GO:0034719	SMN-Sm protein complex
0.35	GO:0070062	extracellular exosome
0.34	GO:0009986	cell surface
0.34	GO:0045202	synapse
0.34	GO:0005794	Golgi apparatus
0.34	GO:0005887	integral component of plasma membrane

0.52

GO:0004104

tr|T1EFZ1|T1EFZ1_HELRO
Uncharacterized protein
Search

PEX13

0.83	Peroxisomal biogenesis factor 13

0.83	GO:0016560	protein import into peroxisome matrix, docking
0.48	GO:0060152	microtubule-based peroxisome localization
0.47	GO:0001561	fatty acid alpha-oxidation
0.46	GO:0021795	cerebral cortex cell migration
0.45	GO:0001764	neuron migration
0.45	GO:0007626	locomotory behavior
0.39	GO:0007265	Ras protein signal transduction
0.38	GO:0001967	suckling behavior
0.34	GO:0018108	peptidyl-tyrosine phosphorylation
0.34	GO:0040028	regulation of vulval development

0.35	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.34	GO:0005154	epidermal growth factor receptor binding
0.34	GO:0005070	SH3/SH2 adaptor activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.76	GO:0005777	peroxisome
0.44	GO:0031903	microbody membrane
0.43	GO:0031301	integral component of organelle membrane
0.33	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane

0.35

GO:0004715

tr|T1EFZ2|T1EFZ2_HELRO
Uncharacterized protein
Search

FUBP3

0.84	Far upstream element binding protein 3

0.50	GO:0006366	transcription by RNA polymerase II
0.50	GO:0045944	positive regulation of transcription by RNA polymerase II

0.59	GO:0003723	RNA binding
0.53	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.53	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.36	GO:0003697	single-stranded DNA binding
0.33	GO:0005515	protein binding
0.32	GO:0016746	transferase activity, transferring acyl groups
0.31	GO:0016787	hydrolase activity

0.44	GO:0005634	nucleus
0.39	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.32

EC:2.3

GO:0016746

tr|T1EFZ3|T1EFZ3_HELRO
Acyl-coenzyme A oxidase
Search

ACOX1

0.61	Acyl-coenzyme A oxidase

0.75	GO:0006635	fatty acid beta-oxidation
0.48	GO:0006692	prostanoid metabolic process
0.46	GO:0000038	very long-chain fatty acid metabolic process
0.44	GO:0007283	spermatogenesis
0.41	GO:1902884	positive regulation of response to oxidative stress
0.39	GO:0006091	generation of precursor metabolites and energy
0.39	GO:0010942	positive regulation of cell death
0.35	GO:0036109	alpha-linolenic acid metabolic process
0.35	GO:2000189	positive regulation of cholesterol homeostasis
0.34	GO:0016559	peroxisome fission

0.81	GO:0003997	acyl-CoA oxidase activity
0.71	GO:0071949	FAD binding
0.46	GO:0047485	protein N-terminus binding
0.46	GO:0030165	PDZ domain binding
0.45	GO:0005102	receptor binding
0.43	GO:0003995	acyl-CoA dehydrogenase activity
0.43	GO:0033791	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity

0.74	GO:0005777	peroxisome
0.44	GO:0031903	microbody membrane
0.42	GO:0005730	nucleolus
0.42	GO:0005654	nucleoplasm
0.39	GO:0005739	mitochondrion
0.38	GO:0005886	plasma membrane
0.37	GO:0005829	cytosol
0.34	GO:0031907	microbody lumen

0.81

EC:1.3.3.6

GO:0003997

tr|T1EFZ4|T1EFZ4_HELRO
Uncharacterized protein
Search

tr|T1EFZ5|T1EFZ5_HELRO
Uncharacterized protein
Search

0.43	Transcription factor

0.38	GO:0007430	terminal branching, open tracheal system
0.38	GO:0035149	lumen formation, open tracheal system
0.35	GO:0009116	nucleoside metabolic process
0.34	GO:0000086	G2/M transition of mitotic cell cycle
0.34	GO:0009749	response to glucose
0.34	GO:0009267	cellular response to starvation
0.33	GO:0000272	polysaccharide catabolic process

0.63	GO:0008270	zinc ion binding
0.35	GO:0046983	protein dimerization activity
0.35	GO:0061770	translation elongation factor binding
0.34	GO:0031176	endo-1,4-beta-xylanase activity

0.37	GO:0005634	nucleus
0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.34

EC:3.2.1.8

GO:0031176

tr|T1EFZ6|T1EFZ6_HELRO
Presenilin
Search

0.40	Presenilin

0.80	GO:0007219	Notch signaling pathway
0.75	GO:0016485	protein processing
0.58	GO:0042987	amyloid precursor protein catabolic process
0.49	GO:0050435	amyloid-beta metabolic process
0.48	GO:0006509	membrane protein ectodomain proteolysis
0.48	GO:0007220	Notch receptor processing
0.47	GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis
0.47	GO:0021870	Cajal-Retzius cell differentiation
0.47	GO:1904797	negative regulation of core promoter binding
0.47	GO:1905908	positive regulation of amyloid fibril formation

0.70	GO:0004190	aspartic-type endopeptidase activity
0.44	GO:0030165	PDZ domain binding
0.44	GO:0008013	beta-catenin binding
0.44	GO:0045296	cadherin binding
0.43	GO:0005262	calcium channel activity
0.33	GO:0004867	serine-type endopeptidase inhibitor activity

0.72	GO:0000139	Golgi membrane
0.70	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.70	GO:0098827	endoplasmic reticulum subcompartment
0.47	GO:0035253	ciliary rootlet
0.47	GO:0043198	dendritic shaft
0.47	GO:0070765	gamma-secretase complex
0.46	GO:0030426	growth cone
0.46	GO:0005790	smooth endoplasmic reticulum
0.45	GO:0030424	axon
0.45	GO:0016235	aggresome

0.70

GO:0004190

tr|T1EFZ7|T1EFZ7_HELRO
Uncharacterized protein
Search

SLC2A8

0.69	Solute carrier family 2, facilitated glucose transporter member 8

0.66	GO:0008643	carbohydrate transport
0.55	GO:0055085	transmembrane transport
0.54	GO:0008286	insulin receptor signaling pathway
0.52	GO:0001666	response to hypoxia
0.43	GO:0007141	male meiosis I
0.41	GO:0015992	proton transport
0.36	GO:0006006	glucose metabolic process

0.57	GO:0022857	transmembrane transporter activity
0.52	GO:0005536	glucose binding

0.46	GO:0005887	integral component of plasma membrane
0.42	GO:0030659	cytoplasmic vesicle membrane
0.41	GO:0008021	synaptic vesicle
0.39	GO:0005765	lysosomal membrane

tr|T1EFZ8|T1EFZ8_HELRO
Uncharacterized protein
Search

0.71	GO:0007010	cytoskeleton organization
0.42	GO:0007519	skeletal muscle tissue development
0.35	GO:0032467	positive regulation of cytokinesis

0.78	GO:0051015	actin filament binding
0.32	GO:0043022	ribosome binding
0.32	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds

0.43	GO:0043034	costamere
0.39	GO:0015629	actin cytoskeleton
0.38	GO:0005829	cytosol
0.37	GO:0030054	cell junction
0.37	GO:0005634	nucleus
0.36	GO:0005886	plasma membrane
0.35	GO:0036449	microtubule minus-end
0.35	GO:0071437	invadopodium
0.35	GO:0032154	cleavage furrow
0.35	GO:0030496	midbody

0.32

GO:0004553

tr|T1EFZ9|T1EFZ9_HELRO
Uncharacterized protein
Search

SOAT1

0.44	O-acyltransferase

0.63	GO:0034435	cholesterol esterification
0.58	GO:0042632	cholesterol homeostasis
0.53	GO:0008203	cholesterol metabolic process
0.53	GO:0042986	positive regulation of amyloid precursor protein biosynthetic process
0.52	GO:0010878	cholesterol storage
0.52	GO:0034379	very-low-density lipoprotein particle assembly
0.52	GO:0010742	macrophage derived foam cell differentiation
0.51	GO:0033344	cholesterol efflux
0.35	GO:0034383	low-density lipoprotein particle clearance
0.33	GO:0006468	protein phosphorylation

0.74	GO:0008374	O-acyltransferase activity
0.49	GO:0015485	cholesterol binding
0.48	GO:0000062	fatty-acyl-CoA binding
0.34	GO:0005201	extracellular matrix structural constituent
0.33	GO:0005515	protein binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.65	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0005903	brush border
0.30	GO:0031224	intrinsic component of membrane

0.74

GO:0008374

tr|T1EG00|T1EG00_HELRO
Uncharacterized protein
Search

GALNT13

0.62	Polypeptide N-acetylgalactosaminyltransferase

0.71	GO:0006486	protein glycosylation
0.46	GO:0018210	peptidyl-threonine modification
0.45	GO:0018209	peptidyl-serine modification
0.35	GO:0001731	formation of translation preinitiation complex
0.35	GO:0006446	regulation of translational initiation
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:0006468	protein phosphorylation

0.67	GO:0030246	carbohydrate binding
0.63	GO:0016757	transferase activity, transferring glycosyl groups
0.39	GO:0140096	catalytic activity, acting on a protein
0.34	GO:0043022	ribosome binding
0.34	GO:0003743	translation initiation factor activity
0.34	GO:0046872	metal ion binding
0.32	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.32	GO:0016301	kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.71	GO:0000139	Golgi membrane
0.35	GO:0016282	eukaryotic 43S preinitiation complex
0.35	GO:0033290	eukaryotic 48S preinitiation complex
0.35	GO:0005852	eukaryotic translation initiation factor 3 complex
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.63

GO:0016757

tr|T1EG01|T1EG01_HELRO
Uncharacterized protein
Search

0.59	Glucose transporter

0.57	GO:0008643	carbohydrate transport
0.55	GO:0055085	transmembrane transport
0.48	GO:0048085	adult chitin-containing cuticle pigmentation
0.47	GO:0090277	positive regulation of peptide hormone secretion
0.45	GO:0042593	glucose homeostasis
0.37	GO:0048731	system development
0.37	GO:0043066	negative regulation of apoptotic process
0.37	GO:0060322	head development
0.37	GO:1904016	response to Thyroglobulin triiodothyronine
0.36	GO:0070837	dehydroascorbic acid transport

0.57	GO:0022857	transmembrane transporter activity
0.37	GO:0033222	xylose binding
0.37	GO:0016936	galactoside binding
0.35	GO:0005536	glucose binding
0.35	GO:0019900	kinase binding

0.36	GO:0002080	acrosomal membrane
0.36	GO:0030672	synaptic vesicle membrane
0.36	GO:0005901	caveola
0.35	GO:0070062	extracellular exosome
0.34	GO:0005887	integral component of plasma membrane

tr|T1EG02|T1EG02_HELRO
Uncharacterized protein
Search

SLC2A2

0.78	Solute carrier family 2, facilitated glucose transporter member 2

0.57	GO:0008643	carbohydrate transport
0.55	GO:0055085	transmembrane transport
0.43	GO:0070837	dehydroascorbic acid transport
0.42	GO:0015747	urate transport
0.41	GO:0046415	urate metabolic process
0.37	GO:0007420	brain development
0.37	GO:0001889	liver development
0.35	GO:1904016	response to Thyroglobulin triiodothyronine
0.35	GO:0015992	proton transport
0.34	GO:0009749	response to glucose

0.57	GO:0022857	transmembrane transporter activity
0.35	GO:0033222	xylose binding
0.35	GO:0016936	galactoside binding
0.34	GO:0005536	glucose binding
0.34	GO:0019900	kinase binding
0.33	GO:0032440	2-alkenal reductase [NAD(P)] activity

0.40	GO:0016324	apical plasma membrane
0.40	GO:0005903	brush border
0.38	GO:0005911	cell-cell junction
0.36	GO:0002080	acrosomal membrane
0.35	GO:0005887	integral component of plasma membrane
0.35	GO:0005635	nuclear envelope
0.34	GO:0030672	synaptic vesicle membrane
0.34	GO:0005901	caveola
0.34	GO:0070062	extracellular exosome
0.34	GO:0016323	basolateral plasma membrane

0.33

EC:1.3.1.74

GO:0032440

tr|T1EG03|T1EG03_HELRO
Uncharacterized protein
Search

0.43	Kinesin light chain

0.36	GO:0036269	swimming behavior
0.36	GO:0010970	transport along microtubule
0.35	GO:0035617	stress granule disassembly
0.35	GO:0040038	polar body extrusion after meiotic divisions
0.35	GO:0051295	establishment of meiotic spindle localization
0.35	GO:0048675	axon extension
0.35	GO:0002119	nematode larval development
0.35	GO:0007097	nuclear migration
0.34	GO:0097193	intrinsic apoptotic signaling pathway
0.34	GO:0097480	establishment of synaptic vesicle localization

0.75	GO:0003777	microtubule motor activity
0.35	GO:0005515	protein binding
0.34	GO:0004697	protein kinase C activity
0.32	GO:0005524	ATP binding
0.32	GO:0046872	metal ion binding

0.81	GO:0005871	kinesin complex
0.39	GO:0005874	microtubule
0.35	GO:0035253	ciliary rootlet
0.35	GO:0030426	growth cone
0.34	GO:0005737	cytoplasm
0.34	GO:0030424	axon
0.34	GO:0044428	nuclear part
0.34	GO:0045202	synapse
0.34	GO:0097708	intracellular vesicle
0.33	GO:0012505	endomembrane system

0.34

EC:2.7.11.13

GO:0004697

tr|T1EG04|T1EG04_HELRO
Uncharacterized protein
Search

RPL3

0.64	Ribosomal protein L3

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.36	GO:0000027	ribosomal large subunit assembly
0.33	GO:0006508	proteolysis
0.32	GO:0016310	phosphorylation
0.32	GO:0055085	transmembrane transport

0.64	GO:0003735	structural constituent of ribosome
0.34	GO:0000829	inositol heptakisphosphate kinase activity
0.34	GO:0016920	pyroglutamyl-peptidase activity
0.34	GO:0003723	RNA binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0046872	metal ion binding

0.61	GO:0005840	ribosome
0.36	GO:0005829	cytosol
0.34	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.34

EC:3.4.19

GO:0016920

tr|T1EG05|T1EG05_HELRO
Uncharacterized protein
Search

TBCCD1

0.58	TBCC domain-containing protein 1

0.87	GO:0051684	maintenance of Golgi location
0.86	GO:0051661	maintenance of centrosome location
0.77	GO:0030334	regulation of cell migration
0.68	GO:0008360	regulation of cell shape

0.85	GO:0031616	spindle pole centrosome
0.39	GO:0005737	cytoplasm

tr|T1EG06|T1EG06_HELRO
Uncharacterized protein
Search

SLC35E1

0.84	Putative glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter

0.43	GO:0005794	Golgi apparatus
0.30	GO:0044425	membrane part

tr|T1EG07|T1EG07_HELRO
Uncharacterized protein
Search

CNOT3

0.50	CCR4-NOT transcription complex subunit 3

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.45	GO:0034249	negative regulation of cellular amide metabolic process
0.44	GO:0006401	RNA catabolic process
0.44	GO:0032269	negative regulation of cellular protein metabolic process
0.43	GO:0010558	negative regulation of macromolecule biosynthetic process
0.43	GO:0031327	negative regulation of cellular biosynthetic process
0.43	GO:0016071	mRNA metabolic process
0.41	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

0.44	GO:0004535	poly(A)-specific ribonuclease activity
0.33	GO:0005515	protein binding

0.81	GO:0030015	CCR4-NOT core complex
0.61	GO:0005634	nucleus
0.42	GO:0000932	P-body
0.30	GO:0016020	membrane

0.44

EC:3.1.13.4

GO:0004535

tr|T1EG08|T1EG08_HELRO
Uncharacterized protein
Search

DNALI1

0.79	LOW QUALITY PROTEIN: axonemal dynein light intermediate polypeptide 1

0.41	GO:0003341	cilium movement
0.38	GO:0036159	inner dynein arm assembly
0.36	GO:0071897	DNA biosynthetic process
0.35	GO:0006260	DNA replication
0.35	GO:0006281	DNA repair
0.34	GO:0016310	phosphorylation

0.85	GO:0045504	dynein heavy chain binding
0.46	GO:0003774	motor activity
0.39	GO:0050750	low-density lipoprotein particle receptor binding
0.38	GO:0008201	heparin binding
0.36	GO:0003887	DNA-directed DNA polymerase activity
0.35	GO:0008270	zinc ion binding
0.34	GO:0016301	kinase activity
0.34	GO:0003677	DNA binding

0.80	GO:0030175	filopodium
0.78	GO:0005930	axoneme
0.48	GO:0030286	dynein complex
0.38	GO:0008622	epsilon DNA polymerase complex
0.36	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane

0.36

GO:0003887

tr|T1EG09|T1EG09_HELRO
Uncharacterized protein
Search

ACSL6

0.37	Long-chain-fatty-acid--CoA ligase

0.45	GO:0001676	long-chain fatty acid metabolic process
0.45	GO:0007405	neuroblast proliferation
0.35	GO:0010747	positive regulation of plasma membrane long-chain fatty acid transport
0.34	GO:0010867	positive regulation of triglyceride biosynthetic process
0.34	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
0.34	GO:0009629	response to gravity
0.34	GO:0032869	cellular response to insulin stimulus
0.34	GO:0010976	positive regulation of neuron projection development
0.34	GO:0001666	response to hypoxia
0.34	GO:0007584	response to nutrient

0.49	GO:0016874	ligase activity
0.37	GO:0042803	protein homodimerization activity
0.35	GO:0019899	enzyme binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005509	calcium ion binding
0.32	GO:0004359	glutaminase activity

0.38	GO:0005739	mitochondrion
0.36	GO:0031903	microbody membrane
0.36	GO:0044439	peroxisomal part
0.36	GO:0031968	organelle outer membrane
0.35	GO:0005789	endoplasmic reticulum membrane
0.32	GO:0005634	nucleus
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.49

GO:0016874

tr|T1EG10|T1EG10_HELRO
Serine/threonine-protein kinase receptor
Search

0.60	Serine/threonine-protein kinase receptor

0.80	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.66	GO:0023014	signal transduction by protein phosphorylation
0.54	GO:1902731	negative regulation of chondrocyte proliferation
0.53	GO:0002063	chondrocyte development
0.52	GO:0061036	positive regulation of cartilage development
0.52	GO:0060350	endochondral bone morphogenesis
0.51	GO:0030166	proteoglycan biosynthetic process
0.50	GO:0071363	cellular response to growth factor stimulus
0.48	GO:0071495	cellular response to endogenous stimulus
0.46	GO:0071559	response to transforming growth factor beta

0.83	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
0.80	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.43	GO:0046332	SMAD binding
0.43	GO:0046872	metal ion binding
0.34	GO:0050431	transforming growth factor beta binding

0.45	GO:0043235	receptor complex
0.37	GO:0005886	plasma membrane
0.36	GO:0097458	neuron part
0.35	GO:0120025	plasma membrane bounded cell projection
0.35	GO:0044297	cell body
0.34	GO:0044463	cell projection part
0.34	GO:0005771	multivesicular body
0.34	GO:0005769	early endosome
0.33	GO:0044456	synapse part
0.30	GO:0016021	integral component of membrane

0.83

GO:0004675

tr|T1EG11|T1EG11_HELRO
Uncharacterized protein
Search

SIRT4

0.51	NAD-dependent protein deacylase

0.64	GO:0006476	protein deacetylation
0.62	GO:0006471	protein ADP-ribosylation
0.45	GO:0042742	defense response to bacterium
0.43	GO:0031348	negative regulation of defense response
0.40	GO:0016570	histone modification
0.39	GO:0046322	negative regulation of fatty acid oxidation
0.39	GO:1904182	regulation of pyruvate dehydrogenase activity
0.39	GO:0046676	negative regulation of insulin secretion
0.38	GO:0046889	positive regulation of lipid biosynthetic process
0.38	GO:0000820	regulation of glutamine family amino acid metabolic process

0.77	GO:0070403	NAD+ binding
0.65	GO:0034979	NAD-dependent protein deacetylase activity
0.53	GO:0008270	zinc ion binding
0.42	GO:0004407	histone deacetylase activity
0.41	GO:0003950	NAD+ ADP-ribosyltransferase activity
0.40	GO:0061690	lipoamidase activity
0.40	GO:0047708	biotinidase activity
0.33	GO:0036055	protein-succinyllysine desuccinylase activity
0.33	GO:0036054	protein-malonyllysine demalonylase activity

0.57	GO:0005759	mitochondrial matrix
0.40	GO:0005634	nucleus
0.35	GO:0031966	mitochondrial membrane
0.35	GO:0019866	organelle inner membrane
0.30	GO:0031224	intrinsic component of membrane

0.42

EC:3.5.1.98

GO:0004407

tr|T1EG12|T1EG12_HELRO
Uncharacterized protein
Search

HDLBP

0.91	High density lipoprotein binding protein b

0.44	GO:0071391	cellular response to estrogen stimulus
0.38	GO:0008203	cholesterol metabolic process
0.36	GO:0006869	lipid transport
0.36	GO:0034384	high-density lipoprotein particle clearance

0.59	GO:0003723	RNA binding
0.37	GO:0045296	cadherin binding
0.34	GO:0008289	lipid binding

0.48	GO:0005829	cytosol
0.38	GO:0034364	high-density lipoprotein particle
0.35	GO:0005634	nucleus
0.33	GO:0005886	plasma membrane

tr|T1EG13|T1EG13_HELRO
Uncharacterized protein
Search

INSIG1

0.93	Insulin-induced gene protein (Fragment)

0.81	GO:0008203	cholesterol metabolic process
0.60	GO:0060363	cranial suture morphogenesis
0.59	GO:0042474	middle ear morphogenesis
0.58	GO:0010894	negative regulation of steroid biosynthetic process
0.58	GO:0036316	SREBP-SCAP complex retention in endoplasmic reticulum
0.58	GO:1901303	negative regulation of cargo loading into COPII-coated vesicle
0.58	GO:0006991	response to sterol depletion
0.57	GO:0060021	palate development
0.57	GO:0006984	ER-nucleus signaling pathway
0.56	GO:0045717	negative regulation of fatty acid biosynthetic process

0.35

GO:0008134

transcription factor binding

0.64	GO:0005789	endoplasmic reticulum membrane
0.45	GO:0098796	membrane protein complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1EG14|T1EG14_HELRO
Uncharacterized protein
Search

DDX58

0.75	DExD/H-box helicase 58

0.55	GO:0039529	RIG-I signaling pathway
0.54	GO:0035549	positive regulation of interferon-beta secretion
0.54	GO:1904469	positive regulation of tumor necrosis factor secretion
0.54	GO:0009597	detection of virus
0.54	GO:1902741	positive regulation of interferon-alpha secretion
0.53	GO:0071360	cellular response to exogenous dsRNA
0.53	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
0.53	GO:2000778	positive regulation of interleukin-6 secretion
0.53	GO:0002230	positive regulation of defense response to virus by host
0.53	GO:0060760	positive regulation of response to cytokine stimulus

0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.53	GO:0004386	helicase activity
0.51	GO:0003676	nucleic acid binding
0.50	GO:0008270	zinc ion binding
0.49	GO:0031625	ubiquitin protein ligase binding
0.47	GO:0004525	ribonuclease III activity
0.47	GO:0042802	identical protein binding

0.52	GO:0032587	ruffle membrane
0.50	GO:0005923	bicellular tight junction
0.47	GO:0015629	actin cytoskeleton
0.45	GO:0005829	cytosol
0.36	GO:0016442	RISC complex
0.34	GO:0005634	nucleus
0.32	GO:0044430	cytoskeletal part
0.32	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

0.47

EC:3.1.26.3

GO:0004525

tr|T1EG15|T1EG15_HELRO
Isocitrate dehydrogenase [NADP]
Search

IDH2

0.50	Isocitrate dehydrogenase [NADP], mitochondrial

0.81	GO:0006102	isocitrate metabolic process
0.66	GO:0006099	tricarboxylic acid cycle
0.34	GO:0006103	2-oxoglutarate metabolic process
0.34	GO:0006097	glyoxylate cycle
0.34	GO:0030097	hemopoiesis
0.34	GO:0006537	glutamate biosynthetic process

0.79	GO:0004450	isocitrate dehydrogenase (NADP+) activity
0.68	GO:0051287	NAD binding
0.64	GO:0000287	magnesium ion binding

0.38	GO:0005777	peroxisome
0.37	GO:0005829	cytosol
0.37	GO:0005739	mitochondrion
0.36	GO:0019866	organelle inner membrane
0.33	GO:0009295	nucleoid
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

0.79

EC:1.1.1.42

GO:0004450

tr|T1EG16|T1EG16_HELRO
Uncharacterized protein
Search

0.57	NAD-dependent protein deacetylase

0.76	GO:0016575	histone deacetylation
0.45	GO:0034983	peptidyl-lysine deacetylation
0.43	GO:0008340	determination of adult lifespan
0.40	GO:2000757	negative regulation of peptidyl-lysine acetylation
0.38	GO:0009060	aerobic respiration
0.35	GO:2000777	positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
0.35	GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
0.35	GO:0090042	tubulin deacetylation
0.35	GO:0048012	hepatocyte growth factor receptor signaling pathway
0.35	GO:1900425	negative regulation of defense response to bacterium

0.77	GO:0017136	NAD-dependent histone deacetylase activity
0.77	GO:0070403	NAD+ binding
0.60	GO:0008270	zinc ion binding
0.39	GO:0031078	histone deacetylase activity (H3-K14 specific)
0.36	GO:0034739	histone deacetylase activity (H4-K16 specific)
0.35	GO:0042903	tubulin deacetylase activity
0.35	GO:0035035	histone acetyltransferase binding
0.34	GO:0042826	histone deacetylase binding
0.34	GO:0043130	ubiquitin binding
0.34	GO:0003682	chromatin binding

0.38	GO:0005759	mitochondrial matrix
0.36	GO:0031966	mitochondrial membrane
0.36	GO:0019866	organelle inner membrane
0.34	GO:1902377	nuclear rDNA heterochromatin
0.34	GO:0030496	midbody
0.34	GO:1990707	nuclear subtelomeric heterochromatin
0.34	GO:0034507	chromosome, centromeric outer repeat region
0.34	GO:0005814	centriole
0.34	GO:0031934	mating-type region heterochromatin
0.34	GO:0072686	mitotic spindle

0.34

EC:2.4.2.30

GO:0003950

tr|T1EG17|T1EG17_HELRO
GTP:AMP phosphotransferase, mitochondrial
Search

0.56	GTP:AMP phosphotransferase, mitochondrial

0.74	GO:0046041	ITP metabolic process
0.73	GO:0006172	ADP biosynthetic process
0.71	GO:0046033	AMP metabolic process
0.69	GO:0046939	nucleotide phosphorylation
0.67	GO:0046039	GTP metabolic process
0.51	GO:0032261	purine nucleotide salvage
0.46	GO:0046051	UTP metabolic process
0.39	GO:0046034	ATP metabolic process
0.38	GO:0009142	nucleoside triphosphate biosynthetic process
0.37	GO:0001889	liver development

0.78	GO:0004017	adenylate kinase activity
0.76	GO:0046899	nucleoside triphosphate adenylate kinase activity
0.58	GO:0032550	purine ribonucleoside binding
0.58	GO:0019001	guanyl nucleotide binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0008270	zinc ion binding
0.44	GO:0004550	nucleoside diphosphate kinase activity
0.34	GO:0004756	selenide, water dikinase activity

0.66	GO:0005759	mitochondrial matrix
0.36	GO:0031090	organelle membrane
0.36	GO:0005740	mitochondrial envelope
0.34	GO:0044437	vacuolar part
0.34	GO:0070062	extracellular exosome
0.33	GO:0031970	organelle envelope lumen
0.33	GO:0098805	whole membrane
0.33	GO:0005794	Golgi apparatus
0.32	GO:0005634	nucleus

0.78	EC:2.7.4.3	GO:0004017
0.34	KEGG:R03595	GO:0004756

tr|T1EG18|T1EG18_HELRO
Uncharacterized protein
Search

0.49	GO:0006342	chromatin silencing
0.48	GO:0006338	chromatin remodeling
0.38	GO:0070828	heterochromatin organization
0.37	GO:0031497	chromatin assembly
0.36	GO:0009405	pathogenesis
0.36	GO:0006783	heme biosynthetic process

0.47	GO:0000976	transcription regulatory region sequence-specific DNA binding
0.46	GO:0003682	chromatin binding
0.37	GO:0004325	ferrochelatase activity

0.39	GO:0070701	mucus layer
0.38	GO:0005677	chromatin silencing complex
0.36	GO:0000785	chromatin
0.30	GO:0016020	membrane

0.37	EC:4.99.1.1	GO:0004325
0.37	KEGG:R00310	GO:0004325

tr|T1EG19|T1EG19_HELRO
Uncharacterized protein
Search

0.73	Preprotein translocase YidC subunit

0.76	GO:0051205	protein insertion into membrane
0.50	GO:0015031	protein transport
0.36	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly
0.35	GO:0090151	establishment of protein localization to mitochondrial membrane
0.35	GO:0007007	inner mitochondrial membrane organization
0.35	GO:0000002	mitochondrial genome maintenance
0.35	GO:1990542	mitochondrial transmembrane transport
0.34	GO:0046907	intracellular transport
0.33	GO:0034220	ion transmembrane transport

0.36	GO:0097177	mitochondrial ribosome binding
0.36	GO:0032977	membrane insertase activity
0.34	GO:0005216	ion channel activity
0.33	GO:0005525	GTP binding

0.45	GO:0005886	plasma membrane
0.36	GO:0097002	mitochondrial inner boundary membrane
0.36	GO:0030061	mitochondrial crista
0.35	GO:0005762	mitochondrial large ribosomal subunit
0.30	GO:0016021	integral component of membrane

tr|T1EG20|T1EG20_HELRO
Uncharacterized protein
Search

0.45	GO:0030198	extracellular matrix organization
0.43	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
0.42	GO:1902284	neuron projection extension involved in neuron projection guidance
0.41	GO:0048675	axon extension
0.41	GO:0007412	axon target recognition
0.41	GO:0007528	neuromuscular junction development
0.40	GO:0031290	retinal ganglion cell axon guidance
0.39	GO:0048513	animal organ development
0.39	GO:0071230	cellular response to amino acid stimulus
0.38	GO:0072001	renal system development

0.73	GO:0005201	extracellular matrix structural constituent
0.48	GO:0042302	structural constituent of cuticle
0.37	GO:0004867	serine-type endopeptidase inhibitor activity
0.35	GO:0048407	platelet-derived growth factor binding
0.35	GO:0004842	ubiquitin-protein transferase activity
0.33	GO:0008270	zinc ion binding
0.32	GO:0003700	DNA binding transcription factor activity

0.73	GO:0005581	collagen trimer
0.70	GO:0005604	basement membrane
0.46	GO:0098645	collagen network
0.40	GO:0031594	neuromuscular junction
0.37	GO:0005615	extracellular space
0.33	GO:0044204	host cell nuclear matrix
0.33	GO:0019033	viral tegument
0.30	GO:0016020	membrane

0.35

KEGG:R03876

GO:0004842

tr|T1EG21|T1EG21_HELRO
Uncharacterized protein
Search

0.10	Collagen alpha-1(IV) chain

0.48	GO:0030198	extracellular matrix organization
0.45	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
0.45	GO:0007275	multicellular organism development
0.45	GO:0009888	tissue development
0.42	GO:0071230	cellular response to amino acid stimulus
0.42	GO:0007528	neuromuscular junction development
0.42	GO:0061061	muscle structure development
0.42	GO:0009653	anatomical structure morphogenesis
0.40	GO:0060322	head development
0.38	GO:0048588	developmental cell growth

0.75	GO:0005201	extracellular matrix structural constituent
0.43	GO:0048407	platelet-derived growth factor binding
0.37	GO:0030246	carbohydrate binding
0.36	GO:0030169	low-density lipoprotein particle binding
0.36	GO:0008329	signaling pattern recognition receptor activity
0.35	GO:0005178	integrin binding
0.34	GO:0042302	structural constituent of cuticle
0.33	GO:0030674	protein binding, bridging
0.33	GO:0004867	serine-type endopeptidase inhibitor activity
0.32	GO:0046872	metal ion binding

0.75	GO:0005581	collagen trimer
0.74	GO:0005604	basement membrane
0.47	GO:0098645	collagen network
0.40	GO:0005615	extracellular space
0.35	GO:0031594	neuromuscular junction
0.34	GO:0005783	endoplasmic reticulum
0.33	GO:0070013	intracellular organelle lumen
0.32	GO:1903561	extracellular vesicle
0.32	GO:0044446	intracellular organelle part
0.32	GO:0019012	virion

0.32

GO:0016787

tr|T1EG22|T1EG22_HELRO
Uncharacterized protein
Search

0.53	Serine protease inhibitor serpin

0.57	GO:0010951	negative regulation of endopeptidase activity
0.42	GO:0006508	proteolysis
0.41	GO:2000266	regulation of blood coagulation, intrinsic pathway
0.35	GO:0030155	regulation of cell adhesion
0.34	GO:0071391	cellular response to estrogen stimulus
0.34	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

0.59	GO:0004867	serine-type endopeptidase inhibitor activity
0.42	GO:0008233	peptidase activity
0.39	GO:0008201	heparin binding
0.33	GO:0005509	calcium ion binding
0.32	GO:0016740	transferase activity

0.73	GO:0005615	extracellular space
0.38	GO:0060205	cytoplasmic vesicle lumen
0.37	GO:0043025	neuronal cell body
0.36	GO:0030141	secretory granule
0.35	GO:0031012	extracellular matrix
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.42

GO:0008233

tr|T1EG23|T1EG23_HELRO
Uncharacterized protein
Search

0.66	GO:0042254	ribosome biogenesis
0.44	GO:0016072	rRNA metabolic process
0.42	GO:0034470	ncRNA processing
0.35	GO:0009793	embryo development ending in seed dormancy
0.33	GO:0016310	phosphorylation
0.33	GO:0043043	peptide biosynthetic process
0.33	GO:0000966	RNA 5'-end processing
0.33	GO:0044267	cellular protein metabolic process
0.32	GO:0009059	macromolecule biosynthetic process
0.32	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

0.36	GO:0032550	purine ribonucleoside binding
0.36	GO:0019001	guanyl nucleotide binding
0.34	GO:0032555	purine ribonucleotide binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0003723	RNA binding
0.33	GO:0016301	kinase activity
0.33	GO:0003735	structural constituent of ribosome
0.33	GO:0005515	protein binding
0.32	GO:0016491	oxidoreductase activity

0.51	GO:0030692	Noc4p-Nop14p complex
0.50	GO:0005730	nucleolus
0.47	GO:0032040	small-subunit processome
0.40	GO:0031965	nuclear membrane
0.35	GO:0005654	nucleoplasm
0.33	GO:0005840	ribosome
0.32	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016491

tr|T1EG24|T1EG24_HELRO
Uncharacterized protein
Search

0.67	14-3-3 protein zeta (inferred by orthology to a D. melanogaster protein)

0.47	GO:0006713	glucocorticoid catabolic process
0.47	GO:0050774	negative regulation of dendrite morphogenesis
0.46	GO:0051049	regulation of transport
0.46	GO:0042921	glucocorticoid receptor signaling pathway
0.45	GO:0086010	membrane depolarization during action potential
0.44	GO:0040024	dauer larval development
0.44	GO:0051220	cytoplasmic sequestering of protein
0.44	GO:0032409	regulation of transporter activity
0.43	GO:1900181	negative regulation of protein localization to nucleus
0.43	GO:0070201	regulation of establishment of protein localization

0.77	GO:0019904	protein domain specific binding
0.46	GO:0035259	glucocorticoid receptor binding
0.45	GO:0044325	ion channel binding
0.45	GO:0017080	sodium channel regulator activity
0.43	GO:0042802	identical protein binding
0.42	GO:0003779	actin binding
0.42	GO:0046982	protein heterodimerization activity
0.42	GO:0019899	enzyme binding
0.41	GO:0004497	monooxygenase activity
0.35	GO:0051219	phosphoprotein binding

0.39	GO:0005634	nucleus
0.38	GO:0005737	cytoplasm
0.37	GO:0071944	cell periphery
0.36	GO:0014704	intercalated disc
0.35	GO:0031982	vesicle
0.35	GO:0043230	extracellular organelle
0.35	GO:0005615	extracellular space
0.33	GO:0031090	organelle membrane
0.33	GO:0044446	intracellular organelle part
0.32	GO:0043234	protein complex

0.33

GO:0004222

tr|T1EG25|T1EG25_HELRO
Uncharacterized protein
Search

RBM39

0.86	RNA binding motif protein 39

0.70	GO:0006397	mRNA processing
0.34	GO:0008380	RNA splicing
0.32	GO:0006351	transcription, DNA-templated
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.59

GO:0003723

RNA binding

0.61	GO:0005634	nucleus
0.42	GO:0005815	microtubule organizing center
0.41	GO:0031974	membrane-enclosed lumen
0.38	GO:0043234	protein complex

tr|T1EG26|T1EG26_HELRO
Uncharacterized protein
Search

tr|T1EG27|T1EG27_HELRO
Uncharacterized protein
Search

WDR7

0.50	WD repeat domain 7

0.77	GO:0002244	hematopoietic progenitor cell differentiation
0.51	GO:0035149	lumen formation, open tracheal system
0.49	GO:0007035	vacuolar acidification
0.49	GO:0008593	regulation of Notch signaling pathway

0.38

GO:0005515

protein binding

0.45

GO:0008021

synaptic vesicle

tr|T1EG28|T1EG28_HELRO
Kinesin-like protein
Search

0.74

GO:0007018

microtubule-based movement

0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0016887	ATPase activity

0.47	GO:0015630	microtubule cytoskeleton
0.46	GO:0044430	cytoskeletal part
0.44	GO:0099512	supramolecular fiber
0.43	GO:0005829	cytosol
0.39	GO:0005886	plasma membrane
0.39	GO:0043234	protein complex
0.36	GO:0030425	dendrite
0.36	GO:0030424	axon
0.35	GO:0030426	growth cone
0.34	GO:0031410	cytoplasmic vesicle

0.39

GO:0016887

tr|T1EG29|T1EG29_HELRO
DNA topoisomerase
Search

TOP3A

0.47	DNA topoisomerase

0.72	GO:0006265	DNA topological change
0.36	GO:0045892	negative regulation of transcription, DNA-templated

0.77	GO:0003917	DNA topoisomerase type I activity
0.56	GO:0008270	zinc ion binding
0.55	GO:0003677	DNA binding

0.63	GO:0005694	chromosome
0.51	GO:0016605	PML body
0.30	GO:0031224	intrinsic component of membrane

0.77

EC:5.99.1.2

GO:0003917

tr|T1EG30|T1EG30_HELRO
Uncharacterized protein
Search

0.85	Serine/threonine protein kinase gpbp

0.56	GO:0120012	intermembrane sphingolipid transfer
0.55	GO:0035621	ER to Golgi ceramide transport
0.52	GO:0070584	mitochondrion morphogenesis
0.50	GO:0007029	endoplasmic reticulum organization
0.50	GO:0055088	lipid homeostasis
0.50	GO:0006936	muscle contraction
0.50	GO:0003007	heart morphogenesis
0.50	GO:0006672	ceramide metabolic process
0.49	GO:0034976	response to endoplasmic reticulum stress
0.49	GO:0008283	cell proliferation

0.71	GO:0008289	lipid binding
0.56	GO:0120017	intermembrane ceramide transfer activity
0.46	GO:0033218	amide binding
0.44	GO:0016301	kinase activity
0.39	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.38	GO:0140096	catalytic activity, acting on a protein
0.34	GO:0043168	anion binding
0.33	GO:0005515	protein binding

0.62	GO:0005581	collagen trimer
0.48	GO:0048471	perinuclear region of cytoplasm
0.47	GO:0005794	Golgi apparatus
0.45	GO:0005654	nucleoplasm
0.45	GO:0005829	cytosol
0.42	GO:0005739	mitochondrion
0.38	GO:0005783	endoplasmic reticulum
0.33	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.33	GO:0031984	organelle subcompartment
0.30	GO:0031224	intrinsic component of membrane

0.39

GO:0016773

tr|T1EG31|T1EG31_HELRO
Uncharacterized protein
Search

PARL

0.90	Presenilin associated rhomboid like

0.61	GO:0006508	proteolysis
0.52	GO:0090201	negative regulation of release of cytochrome c from mitochondria
0.51	GO:1903146	regulation of autophagy of mitochondrion
0.50	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway
0.39	GO:1903214	regulation of protein targeting to mitochondrion
0.39	GO:2000377	regulation of reactive oxygen species metabolic process
0.37	GO:0030162	regulation of proteolysis
0.35	GO:0006851	mitochondrial calcium ion transmembrane transport
0.34	GO:0046294	formaldehyde catabolic process
0.34	GO:0031667	response to nutrient levels

0.69	GO:0004252	serine-type endopeptidase activity
0.35	GO:0008270	zinc ion binding
0.35	GO:0016790	thiolester hydrolase activity
0.33	GO:0004818	glutamate-tRNA ligase activity
0.33	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0005515	protein binding
0.33	GO:0000049	tRNA binding
0.33	GO:0000287	magnesium ion binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding

0.42	GO:0031966	mitochondrial membrane
0.42	GO:0019866	organelle inner membrane
0.36	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.69

GO:0004252

tr|T1EG32|T1EG32_HELRO
Uncharacterized protein
Search

SMIM4

0.79	Small integral membrane protein 4

0.30

GO:0044425

membrane part

tr|T1EG33|T1EG33_HELRO
Uncharacterized protein
Search

0.37	GO:1903506	regulation of nucleic acid-templated transcription
0.37	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.37	GO:0010468	regulation of gene expression
0.34	GO:0006351	transcription, DNA-templated
0.34	GO:0035282	segmentation

0.51	GO:0003676	nucleic acid binding
0.37	GO:0046872	metal ion binding
0.37	GO:0003700	DNA binding transcription factor activity

0.36	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EG34|T1EG34_HELRO
Uncharacterized protein
Search

0.46	Serine proteinase stubble

0.61	GO:0006508	proteolysis
0.59	GO:0007596	blood coagulation
0.40	GO:0072376	protein activation cascade
0.39	GO:0016310	phosphorylation
0.37	GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway
0.37	GO:0050927	positive regulation of positive chemotaxis
0.37	GO:0051897	positive regulation of protein kinase B signaling
0.37	GO:0002690	positive regulation of leukocyte chemotaxis
0.35	GO:0051604	protein maturation
0.34	GO:0030195	negative regulation of blood coagulation

0.69	GO:0004252	serine-type endopeptidase activity
0.53	GO:0005509	calcium ion binding
0.40	GO:0016301	kinase activity

0.48	GO:0005576	extracellular region
0.37	GO:1905286	serine-type peptidase complex
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.69

GO:0004252

tr|T1EG35|T1EG35_HELRO
Uncharacterized protein
Search

EIF2S1

0.76	Eukaryotic translation initiation factor 2 subunit alpha

0.72	GO:0006413	translational initiation
0.47	GO:0032057	negative regulation of translational initiation in response to stress
0.45	GO:0034198	cellular response to amino acid starvation
0.44	GO:1901216	positive regulation of neuron death
0.44	GO:0034644	cellular response to UV
0.43	GO:0034976	response to endoplasmic reticulum stress
0.43	GO:0046777	protein autophosphorylation
0.35	GO:2000676	positive regulation of type B pancreatic cell apoptotic process
0.35	GO:0071287	cellular response to manganese ion
0.35	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity

0.73	GO:0003743	translation initiation factor activity
0.45	GO:0043022	ribosome binding
0.34	GO:0051082	unfolded protein binding
0.34	GO:0004672	protein kinase activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.50	GO:0005850	eukaryotic translation initiation factor 2 complex
0.49	GO:0005851	eukaryotic translation initiation factor 2B complex
0.45	GO:0043614	multi-eIF complex
0.43	GO:0033290	eukaryotic 48S preinitiation complex
0.43	GO:0010494	cytoplasmic stress granule
0.39	GO:0005840	ribosome
0.38	GO:0005634	nucleus
0.35	GO:0044207	translation initiation ternary complex
0.35	GO:0097451	glial limiting end-foot
0.33	GO:0005829	cytosol

tr|T1EG36|T1EG36_HELRO
Uncharacterized protein
Search

OTOF

0.79	Otoferlin a

0.76	GO:0016079	synaptic vesicle exocytosis
0.44	GO:0010996	response to auditory stimulus
0.43	GO:0050885	neuromuscular process controlling balance
0.37	GO:0007605	sensory perception of sound
0.36	GO:0090102	cochlea development
0.35	GO:0140029	exocytic process
0.34	GO:0043623	cellular protein complex assembly
0.33	GO:0061025	membrane fusion

0.64	GO:0005509	calcium ion binding
0.36	GO:0035612	AP-2 adaptor complex binding
0.34	GO:0003676	nucleic acid binding

0.72	GO:0098793	presynapse
0.39	GO:0099501	exocytic vesicle membrane
0.38	GO:0016323	basolateral plasma membrane
0.37	GO:0030054	cell junction
0.37	GO:0005789	endoplasmic reticulum membrane
0.36	GO:0045178	basal part of cell
0.35	GO:0045177	apical part of cell
0.35	GO:0097060	synaptic membrane
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1EG37|T1EG37_HELRO
Uncharacterized protein
Search

tr|T1EG38|T1EG38_HELRO
Uncharacterized protein
Search

0.76	GO:0034198	cellular response to amino acid starvation
0.75	GO:0032008	positive regulation of TOR signaling
0.74	GO:0034629	cellular protein complex localization
0.48	GO:1903432	regulation of TORC1 signaling
0.35	GO:0005975	carbohydrate metabolic process
0.34	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression

0.36	GO:0017056	structural constituent of nuclear pore
0.36	GO:0003676	nucleic acid binding
0.36	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.35	GO:0003700	DNA binding transcription factor activity
0.35	GO:0005515	protein binding

0.79	GO:0035859	Seh1-associated complex
0.76	GO:0098852	lytic vacuole membrane
0.73	GO:0005764	lysosome
0.67	GO:0030054	cell junction
0.63	GO:0005654	nucleoplasm
0.62	GO:0005829	cytosol
0.49	GO:0000306	extrinsic component of vacuolar membrane
0.46	GO:0000324	fungal-type vacuole
0.36	GO:0005643	nuclear pore
0.30	GO:0016021	integral component of membrane

0.36

GO:0004553

tr|T1EG39|T1EG39_HELRO
Uncharacterized protein
Search

SCAI

0.96	Suppressor of cancer cell invasion

0.72	GO:1903507	negative regulation of nucleic acid-templated transcription
0.58	GO:0006351	transcription, DNA-templated
0.55	GO:0035024	negative regulation of Rho protein signal transduction
0.48	GO:0030336	negative regulation of cell migration
0.40	GO:0006355	regulation of transcription, DNA-templated

0.81	GO:0003714	transcription corepressor activity
0.34	GO:0005515	protein binding

0.47	GO:0031965	nuclear membrane
0.38	GO:0005737	cytoplasm
0.33	GO:0005654	nucleoplasm
0.30	GO:0016021	integral component of membrane

tr|T1EG40|T1EG40_HELRO
Uncharacterized protein
Search

0.86	probable tRNA pseudouridine synthase 2

0.72	GO:0001522	pseudouridine synthesis
0.63	GO:0006396	RNA processing

0.72	GO:0009982	pseudouridine synthase activity
0.59	GO:0003723	RNA binding

0.72

EC:5.4.99.12

GO:0009982

tr|T1EG41|T1EG41_HELRO
Uncharacterized protein
Search

RPA1

0.68	Replication protein A subunit

0.66	GO:0006260	DNA replication
0.65	GO:0006310	DNA recombination
0.65	GO:0006281	DNA repair
0.56	GO:0000723	telomere maintenance
0.52	GO:0051321	meiotic cell cycle
0.52	GO:0030491	heteroduplex formation
0.48	GO:0022402	cell cycle process
0.48	GO:0032392	DNA geometric change
0.48	GO:0034502	protein localization to chromosome
0.47	GO:0000280	nuclear division

0.55	GO:0003697	single-stranded DNA binding
0.54	GO:0046872	metal ion binding
0.47	GO:0043565	sequence-specific DNA binding
0.46	GO:0003690	double-stranded DNA binding
0.44	GO:0003684	damaged DNA binding
0.35	GO:0003682	chromatin binding
0.33	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.33	GO:0004672	protein kinase activity
0.33	GO:0005515	protein binding
0.32	GO:0003735	structural constituent of ribosome

0.63	GO:0005662	DNA replication factor A complex
0.53	GO:0000781	chromosome, telomeric region
0.49	GO:0000794	condensed nuclear chromosome
0.48	GO:0016605	PML body
0.44	GO:0005829	cytosol
0.44	GO:0035861	site of double-strand break
0.42	GO:0000790	nuclear chromatin
0.36	GO:0001673	male germ cell nucleus
0.33	GO:0015934	large ribosomal subunit

0.33

GO:0036459

tr|T1EG42|T1EG42_HELRO
Uncharacterized protein
Search

tr|T1EG43|T1EG43_HELRO
Uncharacterized protein
Search

0.45	Fructose-1,6-bisphosphatase isozyme

0.68	GO:0016311	dephosphorylation
0.60	GO:0005975	carbohydrate metabolic process
0.42	GO:0030388	fructose 1,6-bisphosphate metabolic process
0.42	GO:0006002	fructose 6-phosphate metabolic process
0.37	GO:0044283	small molecule biosynthetic process
0.36	GO:0071286	cellular response to magnesium ion
0.36	GO:0045820	negative regulation of glycolytic process
0.36	GO:0051289	protein homotetramerization
0.36	GO:0006111	regulation of gluconeogenesis
0.36	GO:0046580	negative regulation of Ras protein signal transduction

0.79	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity
0.36	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding
0.36	GO:0032550	purine ribonucleoside binding
0.36	GO:0019001	guanyl nucleotide binding
0.35	GO:0016208	AMP binding
0.35	GO:0042802	identical protein binding
0.34	GO:0003830	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0048029	monosaccharide binding
0.33	GO:0046872	metal ion binding

0.39	GO:0005829	cytosol
0.34	GO:0070062	extracellular exosome
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.79

EC:3.1.3.11

GO:0042132

tr|T1EG44|T1EG44_HELRO
Uncharacterized protein
Search

HERC4

0.89	HECT and RLD domain containing E3 ubiquitin protein ligase 4

0.73	GO:0016567	protein ubiquitination
0.52	GO:0007283	spermatogenesis
0.42	GO:0034126	positive regulation of MyD88-dependent toll-like receptor signaling pathway
0.40	GO:1903078	positive regulation of protein localization to plasma membrane
0.39	GO:0035331	negative regulation of hippo signaling
0.37	GO:0006511	ubiquitin-dependent protein catabolic process
0.36	GO:0030154	cell differentiation
0.34	GO:0016310	phosphorylation

0.74	GO:0004842	ubiquitin-protein transferase activity
0.49	GO:0016874	ligase activity
0.46	GO:0061659	ubiquitin-like protein ligase activity
0.36	GO:0003951	NAD+ kinase activity

0.54	GO:0001650	fibrillar center
0.47	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.49	EC:6	GO:0016874
0.74	KEGG:R03876	GO:0004842

tr|T1EG45|T1EG45_HELRO
Uncharacterized protein
Search

0.78	Polymerase delta-interacting protein 2

0.34	GO:0016579	protein deubiquitination
0.34	GO:0006511	ubiquitin-dependent protein catabolic process
0.34	GO:0045454	cell redox homeostasis

0.55	GO:0003677	DNA binding
0.34	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity

0.30	GO:0031224	intrinsic component of membrane
0.30	GO:0005623	cell

0.34

GO:0036459

tr|T1EG46|T1EG46_HELRO
Uncharacterized protein
Search

TOMM20

0.89	Translocase of outer mitochondrial membrane 20

0.71	GO:0006605	protein targeting
0.53	GO:0016031	tRNA import into mitochondrion
0.52	GO:0070096	mitochondrial outer membrane translocase complex assembly
0.52	GO:0072655	establishment of protein localization to mitochondrion
0.48	GO:0071806	protein transmembrane transport
0.47	GO:0017038	protein import
0.44	GO:1905242	response to 3,3',5-triiodo-L-thyronine
0.42	GO:0014850	response to muscle activity
0.35	GO:0016236	macroautophagy
0.35	GO:0016579	protein deubiquitination

0.53	GO:0030943	mitochondrion targeting sequence binding
0.50	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
0.46	GO:0051082	unfolded protein binding
0.33	GO:0003723	RNA binding
0.32	GO:0003677	DNA binding

0.84	GO:0005742	mitochondrial outer membrane translocase complex
0.51	GO:0044233	ER-mitochondrion membrane contact site
0.49	GO:0031307	integral component of mitochondrial outer membrane
0.37	GO:0031012	extracellular matrix
0.33	GO:0005634	nucleus

tr|T1EG47|T1EG47_HELRO
Phosphodiesterase
Search

0.29	Phosphodiesterase

0.60	GO:0007165	signal transduction
0.52	GO:0050995	negative regulation of lipid catabolic process
0.50	GO:0006198	cAMP catabolic process
0.50	GO:0016525	negative regulation of angiogenesis
0.50	GO:0007162	negative regulation of cell adhesion
0.39	GO:0032869	cellular response to insulin stimulus
0.38	GO:0001525	angiogenesis
0.38	GO:0031018	endocrine pancreas development
0.37	GO:0050796	regulation of insulin secretion
0.37	GO:0042593	glucose homeostasis

0.79	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.54	GO:0046872	metal ion binding
0.40	GO:0043422	protein kinase B binding
0.35	GO:0030552	cAMP binding
0.35	GO:0051219	phosphoprotein binding
0.33	GO:0008144	drug binding

0.51	GO:0032045	guanyl-nucleotide exchange factor complex
0.37	GO:0005794	Golgi apparatus
0.37	GO:0005783	endoplasmic reticulum
0.35	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.79

GO:0004114

tr|T1EG48|T1EG48_HELRO
Uncharacterized protein
Search

0.55	GO:0055085	transmembrane transport
0.50	GO:0046415	urate metabolic process
0.43	GO:0015718	monocarboxylic acid transport
0.34	GO:0007165	signal transduction
0.34	GO:0015850	organic hydroxy compound transport
0.33	GO:0032392	DNA geometric change
0.32	GO:0006508	proteolysis
0.32	GO:0006139	nucleobase-containing compound metabolic process

0.43	GO:0008028	monocarboxylic acid transmembrane transporter activity
0.36	GO:0015293	symporter activity
0.34	GO:1901618	organic hydroxy compound transmembrane transporter activity
0.33	GO:0004003	ATP-dependent DNA helicase activity
0.33	GO:0005515	protein binding
0.32	GO:0004222	metalloendopeptidase activity
0.32	GO:0005509	calcium ion binding
0.32	GO:0008270	zinc ion binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0003677	DNA binding

0.39

GO:0005887

integral component of plasma membrane

0.32

GO:0004222

tr|T1EG49|T1EG49_HELRO
Uncharacterized protein
Search

0.48	Acetyl coenzyme A hydrolase transferase

0.74	GO:0006084	acetyl-CoA metabolic process
0.33	GO:0046938	phytochelatin biosynthetic process
0.32	GO:0010038	response to metal ion

0.44	GO:0016740	transferase activity
0.39	GO:0016787	hydrolase activity
0.32	GO:0140096	catalytic activity, acting on a protein
0.31	GO:0046872	metal ion binding

0.33	GO:0005829	cytosol
0.33	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.44

GO:0016740

tr|T1EG50|T1EG50_HELRO
Uncharacterized protein
Search

0.48	GO:0006260	DNA replication
0.46	GO:0007130	synaptonemal complex assembly
0.41	GO:0035235	ionotropic glutamate receptor signaling pathway

0.41	GO:0004970	ionotropic glutamate receptor activity
0.39	GO:0032550	purine ribonucleoside binding
0.39	GO:0019001	guanyl nucleotide binding
0.39	GO:0005515	protein binding
0.36	GO:0032555	purine ribonucleotide binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding

0.48	GO:0005634	nucleus
0.44	GO:0005737	cytoplasm
0.43	GO:0000793	condensed chromosome
0.41	GO:0044427	chromosomal part
0.40	GO:0031974	membrane-enclosed lumen
0.30	GO:0031224	intrinsic component of membrane

tr|T1EG51|T1EG51_HELRO
Uncharacterized protein
Search

ABHD17B

0.35	Alpha/beta hydrolase

0.58	GO:1902816	regulation of protein localization to microtubule
0.57	GO:1905668	positive regulation of protein localization to endosome
0.57	GO:0098734	macromolecule depalmitoylation
0.57	GO:1902473	regulation of protein localization to synapse
0.57	GO:0018345	protein palmitoylation
0.57	GO:1902950	regulation of dendritic spine maintenance
0.55	GO:0042159	lipoprotein catabolic process
0.54	GO:1903828	negative regulation of cellular protein localization
0.51	GO:0035601	protein deacylation
0.34	GO:0072657	protein localization to membrane

0.57	GO:0008474	palmitoyl-(protein) hydrolase activity
0.35	GO:0008236	serine-type peptidase activity

0.54	GO:0055038	recycling endosome membrane
0.54	GO:0014069	postsynaptic density
0.41	GO:0005886	plasma membrane
0.38	GO:0005576	extracellular region

0.57

EC:3.1.2.22

GO:0008474

tr|T1EG52|T1EG52_HELRO
Uncharacterized protein
Search

FHL2

0.63	Four and a half lim domains

0.41	GO:0050832	defense response to fungus
0.37	GO:0055014	atrial cardiac muscle cell development
0.36	GO:0055015	ventricular cardiac muscle cell development
0.36	GO:0060347	heart trabecula formation
0.36	GO:0001649	osteoblast differentiation
0.35	GO:0043066	negative regulation of apoptotic process
0.35	GO:0000122	negative regulation of transcription by RNA polymerase II
0.35	GO:0009725	response to hormone
0.33	GO:0006811	ion transport
0.32	GO:0006351	transcription, DNA-templated

0.54	GO:0046872	metal ion binding
0.35	GO:0042802	identical protein binding
0.35	GO:0008134	transcription factor binding
0.32	GO:0016740	transferase activity

0.36	GO:0030054	cell junction
0.34	GO:0031430	M band
0.34	GO:0030018	Z disc
0.33	GO:0005634	nucleus
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.32

GO:0016740

tr|T1EG53|T1EG53_HELRO
Uncharacterized protein
Search

ABAT

0.53	Mitochondrial 4-aminobutyrate aminotransferase

0.76	GO:0009448	gamma-aminobutyric acid metabolic process
0.53	GO:0048148	behavioral response to cocaine
0.41	GO:1904448	regulation of aspartate secretion
0.41	GO:0014053	negative regulation of gamma-aminobutyric acid secretion
0.40	GO:1902722	positive regulation of prolactin secretion
0.40	GO:0033602	negative regulation of dopamine secretion
0.40	GO:0070474	positive regulation of uterine smooth muscle contraction
0.40	GO:0097151	positive regulation of inhibitory postsynaptic potential
0.40	GO:0045915	positive regulation of catecholamine metabolic process
0.40	GO:0031652	positive regulation of heat generation

0.78	GO:0003867	4-aminobutyrate transaminase activity
0.67	GO:0030170	pyridoxal phosphate binding
0.47	GO:0042803	protein homodimerization activity
0.42	GO:0047298	(S)-3-amino-2-methylpropionate transaminase activity
0.41	GO:0032145	succinate-semialdehyde dehydrogenase binding
0.36	GO:0051536	iron-sulfur cluster binding
0.34	GO:0046872	metal ion binding

0.55	GO:0032144	4-aminobutyrate transaminase complex
0.43	GO:0005739	mitochondrion
0.38	GO:0070013	intracellular organelle lumen
0.37	GO:0043005	neuron projection
0.36	GO:0070062	extracellular exosome
0.36	GO:0044446	intracellular organelle part
0.33	GO:0005829	cytosol
0.33	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.78	EC:2.6.1.19	GO:0003867
0.42	KEGG:R04188	GO:0047298

tr|T1EG54|T1EG54_HELRO
Uncharacterized protein
Search

KDELC1

0.94	KDEL motif-containing protein 1

0.57	GO:0006664	glycolipid metabolic process
0.35	GO:0006260	DNA replication
0.35	GO:0006281	DNA repair
0.34	GO:0045454	cell redox homeostasis
0.34	GO:0043043	peptide biosynthetic process
0.34	GO:0044267	cellular protein metabolic process
0.33	GO:0010467	gene expression

0.60	GO:0046527	glucosyltransferase activity
0.36	GO:0008081	phosphoric diester hydrolase activity
0.35	GO:0003735	structural constituent of ribosome

0.78	GO:0005788	endoplasmic reticulum lumen
0.37	GO:0000808	origin recognition complex
0.34	GO:0005840	ribosome
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.60

GO:0046527

tr|T1EG55|T1EG55_HELRO
Uncharacterized protein
Search

0.64	GO:0006898	receptor-mediated endocytosis
0.59	GO:0006508	proteolysis
0.56	GO:0006887	exocytosis
0.50	GO:0051604	protein maturation
0.36	GO:0032501	multicellular organismal process
0.36	GO:1904447	folic acid import across plasma membrane
0.35	GO:0007599	hemostasis
0.35	GO:2000179	positive regulation of neural precursor cell proliferation
0.35	GO:0042060	wound healing
0.35	GO:0030514	negative regulation of BMP signaling pathway

0.71	GO:0005044	scavenger receptor activity
0.67	GO:0004252	serine-type endopeptidase activity
0.43	GO:0005509	calcium ion binding
0.34	GO:0008061	chitin binding

0.58	GO:0030424	axon
0.58	GO:0043083	synaptic cleft
0.56	GO:0043679	axon terminus
0.54	GO:0030425	dendrite
0.50	GO:0031410	cytoplasmic vesicle
0.44	GO:0005886	plasma membrane
0.35	GO:0005794	Golgi apparatus
0.35	GO:0005903	brush border
0.34	GO:0005905	clathrin-coated pit
0.34	GO:0045177	apical part of cell

0.67

GO:0004252

tr|T1EG56|T1EG56_HELRO
Cytochrome b-c1 complex subunit 6
Search

0.67	Cytochrome b-c1 complex subunit 6, mitochondrial

0.74	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c
0.44	GO:0009060	aerobic respiration

0.74	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
0.62	GO:0009055	electron transfer activity

0.61	GO:0005739	mitochondrion
0.60	GO:0070469	respiratory chain
0.60	GO:0019866	organelle inner membrane
0.46	GO:0070069	cytochrome complex
0.46	GO:1990204	oxidoreductase complex
0.43	GO:0098796	membrane protein complex
0.30	GO:0016021	integral component of membrane

0.74

EC:1.10.2

GO:0016681

tr|T1EG57|T1EG57_HELRO
5-demethoxyubiquinone hydroxylase, mitochondrial
Search

COQ7

0.58	5-demethoxyubiquinone hydroxylase, mitochondrial

0.75	GO:0006743	ubiquinone metabolic process
0.73	GO:1901663	quinone biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.34	GO:0006468	protein phosphorylation
0.33	GO:0000278	mitotic cell cycle

0.70	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
0.62	GO:0008682	2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity
0.51	GO:0046872	metal ion binding
0.37	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.34	GO:1901265	nucleoside phosphate binding
0.33	GO:0036094	small molecule binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0008144	drug binding
0.33	GO:0043168	anion binding
0.33	GO:0003723	RNA binding

0.76	GO:0031314	extrinsic component of mitochondrial inner membrane
0.37	GO:0005886	plasma membrane
0.37	GO:0070985	TFIIK complex
0.33	GO:0000775	chromosome, centromeric region
0.30	GO:0031224	intrinsic component of membrane

0.70

EC:1.14.13

GO:0016709

tr|T1EG58|T1EG58_HELRO
Uncharacterized protein
Search

0.73	Ethanolaminephosphotransferase

0.68	GO:0008654	phospholipid biosynthetic process
0.39	GO:1903955	positive regulation of protein targeting to mitochondrion
0.38	GO:0046337	phosphatidylethanolamine metabolic process
0.37	GO:0045017	glycerolipid biosynthetic process
0.34	GO:0046470	phosphatidylcholine metabolic process
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:1901566	organonitrogen compound biosynthetic process
0.32	GO:0006518	peptide metabolic process
0.32	GO:0043604	amide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process

0.72	GO:0016780	phosphotransferase activity, for other substituted phosphate groups
0.33	GO:0004930	G-protein coupled receptor activity
0.33	GO:0003723	RNA binding
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0046872	metal ion binding

0.34	GO:0071203	WASH complex
0.32	GO:0005840	ribosome
0.30	GO:0016020	membrane

0.72

GO:0016780

tr|T1EG59|T1EG59_HELRO
Uncharacterized protein
Search

SCFD1

0.94	Sec1 family domain-containing protein 1 isoform a

0.80	GO:0006904	vesicle docking involved in exocytosis
0.52	GO:1902902	negative regulation of autophagosome assembly
0.48	GO:1901998	toxin transport
0.48	GO:0051223	regulation of protein transport
0.44	GO:0009636	response to toxic substance
0.43	GO:0034436	glycoprotein transport
0.42	GO:0048702	embryonic neurocranium morphogenesis
0.42	GO:0031101	fin regeneration
0.41	GO:0006888	ER to Golgi vesicle-mediated transport
0.41	GO:0051216	cartilage development

0.37	GO:0047485	protein N-terminus binding
0.37	GO:0019905	syntaxin binding
0.34	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.33	GO:0016887	ATPase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.49	GO:0005801	cis-Golgi network
0.37	GO:0017119	Golgi transport complex
0.37	GO:0032580	Golgi cisterna membrane
0.36	GO:0005798	Golgi-associated vesicle
0.36	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0005886	plasma membrane
0.33	GO:0005829	cytosol
0.33	GO:0098533	ATPase dependent transmembrane transport complex
0.33	GO:0098796	membrane protein complex

0.34

GO:0004114

tr|T1EG60|T1EG60_HELRO
Uncharacterized protein
Search

0.57	GO:0016310	phosphorylation
0.49	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
0.47	GO:2000811	negative regulation of anoikis
0.47	GO:0071398	cellular response to fatty acid
0.47	GO:0008286	insulin receptor signaling pathway
0.47	GO:0046320	regulation of fatty acid oxidation
0.47	GO:0045124	regulation of bone resorption
0.46	GO:0042304	regulation of fatty acid biosynthetic process
0.46	GO:0010906	regulation of glucose metabolic process
0.45	GO:0042593	glucose homeostasis

0.59	GO:0016301	kinase activity
0.41	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.40	GO:0140096	catalytic activity, acting on a protein
0.38	GO:0032559	adenyl ribonucleotide binding
0.38	GO:0008144	drug binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding

0.40	GO:0044429	mitochondrial part
0.39	GO:0019866	organelle inner membrane
0.36	GO:0031974	membrane-enclosed lumen
0.36	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.41

GO:0016773

tr|T1EG61|T1EG61_HELRO
Uncharacterized protein
Search

0.57	Phosphatidylinositol glycan anchor biosynthesis class K

0.82	GO:0016255	attachment of GPI anchor to protein
0.61	GO:0006508	proteolysis
0.44	GO:0034394	protein localization to cell surface
0.35	GO:0006030	chitin metabolic process
0.34	GO:0034968	histone lysine methylation
0.33	GO:0006099	tricarboxylic acid cycle
0.33	GO:0034220	ion transmembrane transport

0.85	GO:0003923	GPI-anchor transamidase activity
0.61	GO:0008233	peptidase activity
0.35	GO:0008061	chitin binding
0.34	GO:0004449	isocitrate dehydrogenase (NAD+) activity
0.34	GO:0018024	histone-lysine N-methyltransferase activity
0.33	GO:0005216	ion channel activity
0.33	GO:0051287	NAD binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0000287	magnesium ion binding
0.33	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

0.81	GO:0042765	GPI-anchor transamidase complex
0.34	GO:0005576	extracellular region
0.33	GO:0005694	chromosome
0.33	GO:0005634	nucleus
0.33	GO:0005739	mitochondrion

0.85

GO:0003923

tr|T1EG62|T1EG62_HELRO
Uncharacterized protein
Search

ILK

0.49	Integrin-linked protein kinase

0.65	GO:0007229	integrin-mediated signaling pathway
0.63	GO:0006468	protein phosphorylation
0.46	GO:0007160	cell-matrix adhesion
0.45	GO:0016203	muscle attachment
0.45	GO:0007475	apposition of dorsal and ventral imaginal disc-derived wing surfaces
0.41	GO:0034446	substrate adhesion-dependent cell spreading
0.38	GO:0055002	striated muscle cell development
0.38	GO:1904901	positive regulation of myosin II filament organization
0.38	GO:0048815	hermaphrodite genitalia morphogenesis
0.38	GO:1903356	positive regulation of distal tip cell migration

0.64	GO:0004672	protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.37	GO:0004871	signal transducer activity
0.37	GO:0005178	integrin binding
0.36	GO:0030674	protein binding, bridging
0.34	GO:0102568	phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
0.34	GO:0102567	phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)

0.46	GO:0005925	focal adhesion
0.41	GO:0001725	stress fiber
0.38	GO:0030017	sarcomere
0.37	GO:0055120	striated muscle dense body
0.37	GO:0009925	basal plasma membrane
0.36	GO:0008305	integrin complex
0.36	GO:0042383	sarcolemma
0.35	GO:0005730	nucleolus

0.34

EC:3.1.1.4

GO:0004623

tr|T1EG63|T1EG63_HELRO
Uncharacterized protein
Search

tr|T1EG64|T1EG64_HELRO
Uncharacterized protein
Search

PRPF38B

0.86	Pre-mRNA processing factor 38B

0.53	GO:0008380	RNA splicing
0.51	GO:0006397	mRNA processing

0.41

GO:0003723

RNA binding

0.84	GO:0071011	precatalytic spliceosome
0.30	GO:0031224	intrinsic component of membrane

tr|T1EG65|T1EG65_HELRO
Uncharacterized protein
Search

0.10	Carboxylic ester hydrolase

0.36	GO:0008340	determination of adult lifespan
0.36	GO:0046683	response to organophosphorus
0.36	GO:0019915	lipid storage
0.35	GO:0006581	acetylcholine catabolic process
0.35	GO:0007271	synaptic transmission, cholinergic
0.35	GO:0043043	peptide biosynthetic process
0.34	GO:0044267	cellular protein metabolic process
0.34	GO:0097105	presynaptic membrane assembly
0.34	GO:0097104	postsynaptic membrane assembly
0.34	GO:0007158	neuron cell-cell adhesion

0.48	GO:0016787	hydrolase activity
0.35	GO:0003735	structural constituent of ribosome
0.34	GO:0042803	protein homodimerization activity
0.34	GO:0042043	neurexin family protein binding
0.34	GO:0005549	odorant binding
0.32	GO:0004872	receptor activity
0.32	GO:0008270	zinc ion binding
0.32	GO:0003677	DNA binding

0.35	GO:0005840	ribosome
0.33	GO:0009986	cell surface
0.33	GO:0045202	synapse
0.33	GO:0005576	extracellular region
0.33	GO:0005887	integral component of plasma membrane
0.32	GO:0005634	nucleus

0.48

GO:0016787

tr|T1EG66|T1EG66_HELRO
Uncharacterized protein
Search

0.53	TBC1 domain family member 1

0.67	GO:0043547	positive regulation of GTPase activity
0.49	GO:0031338	regulation of vesicle fusion
0.48	GO:0032869	cellular response to insulin stimulus
0.46	GO:0033627	cell adhesion mediated by integrin
0.43	GO:0006886	intracellular protein transport
0.43	GO:0016192	vesicle-mediated transport
0.37	GO:0051051	negative regulation of transport
0.37	GO:0010639	negative regulation of organelle organization
0.36	GO:0032880	regulation of protein localization
0.35	GO:1902017	regulation of cilium assembly

0.68	GO:0005096	GTPase activator activity
0.52	GO:0017137	Rab GTPase binding
0.45	GO:0005178	integrin binding
0.33	GO:0008237	metallopeptidase activity

0.46	GO:0012505	endomembrane system
0.43	GO:0009986	cell surface
0.43	GO:0005829	cytosol
0.38	GO:0043227	membrane-bounded organelle
0.37	GO:0043229	intracellular organelle
0.36	GO:0043230	extracellular organelle
0.35	GO:0005615	extracellular space
0.32	GO:0044422	organelle part
0.30	GO:0016020	membrane

tr|T1EG67|T1EG67_HELRO
Uncharacterized protein
Search

MAU2

0.91	Cohesin loading complex subunit A

0.82	GO:0007064	mitotic sister chromatid cohesion
0.59	GO:0034086	maintenance of sister chromatid cohesion
0.54	GO:0071921	cohesin loading
0.41	GO:0051301	cell division
0.34	GO:0007411	axon guidance

0.51	GO:0047485	protein N-terminus binding
0.41	GO:0003690	double-stranded DNA binding

0.59	GO:0032116	SMC loading complex
0.50	GO:0000785	chromatin
0.49	GO:0005654	nucleoplasm

tr|T1EG68|T1EG68_HELRO
Coronin
Search

0.68

Coronin

0.72	GO:0030036	actin cytoskeleton organization
0.41	GO:0007527	adult somatic muscle development
0.39	GO:0050832	defense response to fungus

0.76

GO:0051015

actin filament binding

0.72	GO:0015629	actin cytoskeleton
0.30	GO:0016021	integral component of membrane

tr|T1EG69|T1EG69_HELRO
Uncharacterized protein
Search

0.68

Coronin

0.70	GO:0030036	actin cytoskeleton organization
0.59	GO:0001845	phagolysosome assembly
0.57	GO:0060326	cell chemotaxis
0.56	GO:0050900	leukocyte migration
0.52	GO:0061502	early endosome to recycling endosome transport
0.52	GO:0032796	uropod organization
0.52	GO:0051126	negative regulation of actin nucleation
0.51	GO:0043320	natural killer cell degranulation
0.51	GO:0038180	nerve growth factor signaling pathway
0.51	GO:0031339	negative regulation of vesicle fusion

0.77	GO:0051015	actin filament binding
0.51	GO:0032036	myosin heavy chain binding
0.50	GO:0043548	phosphatidylinositol 3-kinase binding
0.49	GO:0003785	actin monomer binding
0.48	GO:0008022	protein C-terminus binding
0.47	GO:0042802	identical protein binding
0.43	GO:0046983	protein dimerization activity
0.41	GO:0071933	Arp2/3 complex binding
0.40	GO:0045296	cadherin binding

0.70	GO:0015629	actin cytoskeleton
0.50	GO:0030027	lamellipodium
0.50	GO:0001891	phagocytic cup
0.49	GO:0001772	immunological synapse
0.48	GO:0045335	phagocytic vesicle
0.47	GO:0030863	cortical cytoskeleton
0.47	GO:0005769	early endosome
0.47	GO:0030424	axon
0.46	GO:0099513	polymeric cytoskeletal fiber
0.46	GO:0005911	cell-cell junction

tr|T1EG70|T1EG70_HELRO
Uncharacterized protein
Search

0.41	GO:0034109	homotypic cell-cell adhesion
0.41	GO:0014841	skeletal muscle satellite cell proliferation
0.41	GO:0014816	skeletal muscle satellite cell differentiation
0.40	GO:0014719	skeletal muscle satellite cell activation
0.40	GO:0055001	muscle cell development
0.39	GO:0048646	anatomical structure formation involved in morphogenesis
0.39	GO:0006909	phagocytosis
0.38	GO:0051451	myoblast migration
0.38	GO:0003407	neural retina development
0.38	GO:0060042	retina morphogenesis in camera-type eye

0.59	GO:0005509	calcium ion binding
0.38	GO:0001849	complement component C1q binding
0.38	GO:0005112	Notch binding
0.37	GO:0005044	scavenger receptor activity
0.34	GO:0004725	protein tyrosine phosphatase activity
0.33	GO:0005201	extracellular matrix structural constituent
0.32	GO:0043237	laminin-1 binding
0.32	GO:0043394	proteoglycan binding
0.32	GO:0005518	collagen binding

0.38	GO:0001891	phagocytic cup
0.35	GO:0005576	extracellular region
0.34	GO:0016323	basolateral plasma membrane
0.30	GO:0016021	integral component of membrane

0.34

GO:0004725

tr|T1EG71|T1EG71_HELRO
Uncharacterized protein
Search

SIRT7

0.96	NAD-dependent deacetylase sirtuin 7

0.71	GO:0007072	positive regulation of transcription involved in exit from mitosis
0.66	GO:0070933	histone H4 deacetylation
0.65	GO:0009303	rRNA transcription
0.62	GO:0070932	histone H3 deacetylation
0.59	GO:0000122	negative regulation of transcription by RNA polymerase II
0.54	GO:0002244	hematopoietic progenitor cell differentiation

0.77	GO:0070403	NAD+ binding
0.71	GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)
0.59	GO:0003682	chromatin binding

0.69

GO:0005731

nucleolus organizer region

tr|T1EG72|T1EG72_HELRO
Uncharacterized protein
Search

CWC22

0.84	CWC22 spliceosome associated protein homolog

0.45	GO:0008380	RNA splicing
0.43	GO:0006397	mRNA processing
0.34	GO:0048024	regulation of mRNA splicing, via spliceosome

0.59	GO:0003723	RNA binding
0.34	GO:0005515	protein binding

0.50	GO:0071013	catalytic step 2 spliceosome
0.50	GO:0005684	U2-type spliceosomal complex
0.48	GO:0071012	catalytic step 1 spliceosome
0.46	GO:0016607	nuclear speck
0.42	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

tr|T1EG73|T1EG73_HELRO
E3 ubiquitin-protein ligase
Search

SMURF2

0.57	SMAD specific E3 ubiquitin protein ligase 2

0.72	GO:0016567	protein ubiquitination
0.71	GO:0006511	ubiquitin-dependent protein catabolic process
0.53	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
0.53	GO:0090288	negative regulation of cellular response to growth factor stimulus
0.53	GO:1901165	positive regulation of trophoblast cell migration
0.52	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.51	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
0.49	GO:0030510	regulation of BMP signaling pathway
0.40	GO:0061753	substrate localization to autophagosome
0.40	GO:0061736	engulfment of target by autophagosome

0.74	GO:0061630	ubiquitin protein ligase activity
0.53	GO:0016874	ligase activity
0.51	GO:0046332	SMAD binding
0.46	GO:0042802	identical protein binding
0.38	GO:0005160	transforming growth factor beta receptor binding
0.34	GO:0061608	nuclear import signal receptor activity
0.33	GO:0008565	protein transporter activity

0.48	GO:0016607	nuclear speck
0.47	GO:0000151	ubiquitin ligase complex
0.39	GO:0098857	membrane microdomain
0.37	GO:0005737	cytoplasm
0.36	GO:0005886	plasma membrane

0.53

GO:0016874

tr|T1EG74|T1EG74_HELRO
Uncharacterized protein
Search

tr|T1EG75|T1EG75_HELRO
Uncharacterized protein
Search

0.57	Partitioning defective 6 like protein gamma

0.78	GO:0007163	establishment or maintenance of cell polarity
0.48	GO:0045216	cell-cell junction organization
0.47	GO:0001933	negative regulation of protein phosphorylation
0.47	GO:1904781	positive regulation of protein localization to centrosome
0.47	GO:0007430	terminal branching, open tracheal system
0.46	GO:0034331	cell junction maintenance
0.46	GO:0010592	positive regulation of lamellipodium assembly
0.46	GO:0055059	asymmetric neuroblast division
0.45	GO:0051491	positive regulation of filopodium assembly
0.45	GO:0007298	border follicle cell migration

0.46	GO:0030742	GTP-dependent protein binding
0.46	GO:0005080	protein kinase C binding
0.43	GO:0017048	Rho GTPase binding
0.35	GO:0005509	calcium ion binding
0.34	GO:0008134	transcription factor binding
0.34	GO:0016780	phosphotransferase activity, for other substituted phosphate groups

0.47	GO:0005938	cell cortex
0.47	GO:0097482	muscle cell postsynaptic specialization
0.46	GO:0034451	centriolar satellite
0.45	GO:0043195	terminal bouton
0.45	GO:0043296	apical junction complex
0.45	GO:0016324	apical plasma membrane
0.44	GO:0070160	occluding junction
0.39	GO:0005634	nucleus
0.38	GO:0043234	protein complex
0.35	GO:0044295	axonal growth cone

0.34

GO:0016780

tr|T1EG76|T1EG76_HELRO
Protein Wnt
Search

tr|T1EG77|T1EG77_HELRO
Uncharacterized protein
Search

RCL1

0.58	RNA 3'terminal phosphate cyclaselike proteinlike [Oreochromis niloticus]

0.67	GO:0042254	ribosome biogenesis
0.63	GO:0006396	RNA processing
0.48	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.47	GO:0016072	rRNA metabolic process
0.36	GO:0043085	positive regulation of catalytic activity
0.35	GO:0006069	ethanol oxidation

0.47	GO:0003963	RNA-3'-phosphate cyclase activity
0.44	GO:0004521	endoribonuclease activity
0.36	GO:0008047	enzyme activator activity
0.35	GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase activity
0.34	GO:0008270	zinc ion binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.73	GO:0005730	nucleolus
0.37	GO:0030686	90S preribosome
0.34	GO:0045335	phagocytic vesicle
0.33	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.47	EC:6.5.1.4	GO:0003963
0.35	KEGG:R06983 KEGG:R07140	GO:0051903

tr|T1EG78|T1EG78_HELRO
Uncharacterized protein
Search

GDPD1

0.93	Glycerophosphodiester phosphodiesterase domain-containing protein 1

0.61	GO:0006629	lipid metabolic process
0.57	GO:0070291	N-acylethanolamine metabolic process
0.42	GO:0019637	organophosphate metabolic process
0.41	GO:0006796	phosphate-containing compound metabolic process
0.37	GO:0007420	brain development

0.70	GO:0008081	phosphoric diester hydrolase activity
0.53	GO:0004622	lysophospholipase activity

0.51	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.70

GO:0008081

tr|T1EG79|T1EG79_HELRO
Uncharacterized protein
Search

0.48	GO:0061008	hepaticobiliary system development
0.37	GO:1904413	negative regulation of cardiac ventricle development
0.36	GO:0007015	actin filament organization
0.35	GO:0050901	leukocyte tethering or rolling
0.35	GO:0032092	positive regulation of protein binding
0.34	GO:0051016	barbed-end actin filament capping
0.34	GO:0030097	hemopoiesis
0.33	GO:0006461	protein complex assembly

0.42	GO:0005198	structural molecule activity
0.35	GO:0003779	actin binding
0.35	GO:0030507	spectrin binding
0.34	GO:0046983	protein dimerization activity
0.34	GO:0019901	protein kinase binding
0.34	GO:0005516	calmodulin binding
0.34	GO:0032403	protein complex binding
0.34	GO:0042802	identical protein binding

0.66	GO:0005856	cytoskeleton
0.49	GO:0014069	postsynaptic density
0.49	GO:0005903	brush border
0.47	GO:0000794	condensed nuclear chromosome
0.46	GO:0005911	cell-cell junction
0.46	GO:0005938	cell cortex
0.44	GO:0005654	nucleoplasm
0.39	GO:0005886	plasma membrane
0.34	GO:0045121	membrane raft
0.34	GO:0031410	cytoplasmic vesicle

tr|T1EG80|T1EG80_HELRO
Uncharacterized protein
Search

ETHE1

0.51	Beta lactamase domain

0.54	GO:0006749	glutathione metabolic process
0.54	GO:0070813	hydrogen sulfide metabolic process
0.47	GO:0055114	oxidation-reduction process

0.63	GO:0050313	sulfur dioxygenase activity
0.47	GO:0005506	iron ion binding
0.43	GO:0004416	hydroxyacylglutathione hydrolase activity
0.37	GO:0008201	heparin binding

0.51	GO:0005654	nucleoplasm
0.46	GO:0005739	mitochondrion
0.30	GO:0044425	membrane part

0.63

EC:1.13.11.18

GO:0050313

tr|T1EG81|T1EG81_HELRO
Uncharacterized protein
Search

0.70	Mitogen inducible protein product

0.80	GO:0007229	integrin-mediated signaling pathway
0.44	GO:0007160	cell-matrix adhesion
0.43	GO:0048856	anatomical structure development
0.43	GO:0033622	integrin activation
0.43	GO:0007045	cell-substrate adherens junction assembly
0.41	GO:0007179	transforming growth factor beta receptor signaling pathway
0.41	GO:1904901	positive regulation of myosin II filament organization
0.41	GO:1903356	positive regulation of distal tip cell migration
0.41	GO:0016055	Wnt signaling pathway
0.41	GO:0032501	multicellular organismal process

0.42	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.39	GO:0043621	protein self-association
0.39	GO:0005178	integrin binding
0.35	GO:0005198	structural molecule activity
0.33	GO:0003779	actin binding
0.33	GO:0005509	calcium ion binding

0.45	GO:0030055	cell-substrate junction
0.42	GO:0005856	cytoskeleton
0.42	GO:0005912	adherens junction
0.42	GO:0099512	supramolecular fiber
0.41	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.40	GO:0014704	intercalated disc
0.39	GO:0005654	nucleoplasm
0.38	GO:0031258	lamellipodium membrane
0.36	GO:0043234	protein complex
0.36	GO:0005938	cell cortex

tr|T1EG82|T1EG82_HELRO
Uncharacterized protein
Search

0.40	Serine/threonine-protein kinase

0.63	GO:0006468	protein phosphorylation
0.61	GO:0035556	intracellular signal transduction
0.40	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
0.40	GO:1901727	positive regulation of histone deacetylase activity
0.39	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway
0.39	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
0.39	GO:0050862	positive regulation of T cell receptor signaling pathway
0.39	GO:0032743	positive regulation of interleukin-2 production
0.39	GO:0032793	positive regulation of CREB transcription factor activity
0.39	GO:0032757	positive regulation of interleukin-8 production

0.84	GO:0004697	protein kinase C activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0046872	metal ion binding
0.39	GO:0005080	protein kinase C binding

0.44	GO:0005622	intracellular
0.36	GO:0031974	membrane-enclosed lumen
0.34	GO:0044422	organelle part
0.34	GO:0043227	membrane-bounded organelle
0.30	GO:0016020	membrane

0.84

EC:2.7.11.13

GO:0004697

tr|T1EG83|T1EG83_HELRO
Uncharacterized protein
Search

ARHGAP39

0.56	Rho GTPase activating protein 39

0.61	GO:0007165	signal transduction
0.34	GO:0051056	regulation of small GTPase mediated signal transduction
0.34	GO:0043547	positive regulation of GTPase activity

0.34

GO:0005096

GTPase activator activity

0.68	GO:0005856	cytoskeleton
0.34	GO:0005829	cytosol
0.33	GO:0005634	nucleus
0.30	GO:0044425	membrane part

tr|T1EG84|T1EG84_HELRO
L-lactate dehydrogenase
Search

LDHA

0.53	L-lactate dehydrogenase A chain

0.60	GO:0005975	carbohydrate metabolic process
0.57	GO:0019752	carboxylic acid metabolic process
0.53	GO:0055114	oxidation-reduction process
0.40	GO:0001666	response to hypoxia
0.37	GO:0030317	flagellated sperm motility
0.36	GO:1901617	organic hydroxy compound biosynthetic process
0.35	GO:0006754	ATP biosynthetic process
0.34	GO:0016053	organic acid biosynthetic process
0.34	GO:0009737	response to abscisic acid
0.34	GO:0009651	response to salt stress

0.81	GO:0004459	L-lactate dehydrogenase activity
0.33	GO:0016757	transferase activity, transferring glycosyl groups

0.49	GO:0005737	cytoplasm
0.36	GO:0031514	motile cilium
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.81

EC:1.1.1.27

GO:0004459

tr|T1EG85|T1EG85_HELRO
Uncharacterized protein
Search

RPS16

0.51	Ribosomal protein rps16

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.43	GO:0042274	ribosomal small subunit biogenesis
0.41	GO:0016072	rRNA metabolic process
0.41	GO:1990830	cellular response to leukemia inhibitory factor
0.35	GO:0097421	liver regeneration
0.34	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0006556	S-adenosylmethionine biosynthetic process

0.64	GO:0003735	structural constituent of ribosome
0.39	GO:0003723	RNA binding
0.34	GO:0004478	methionine adenosyltransferase activity
0.33	GO:0005515	protein binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0046872	metal ion binding

0.61	GO:0005840	ribosome
0.42	GO:0044445	cytosolic part
0.38	GO:0044446	intracellular organelle part
0.34	GO:0005791	rough endoplasmic reticulum
0.34	GO:0005925	focal adhesion
0.34	GO:0070062	extracellular exosome
0.34	GO:0098562	cytoplasmic side of membrane
0.34	GO:0031012	extracellular matrix
0.33	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.33	GO:0098588	bounding membrane of organelle

0.34

EC:2.5.1.6

GO:0004478

tr|T1EG86|T1EG86_HELRO
Uncharacterized protein
Search

0.53	Zinc transporter 1

0.61	GO:0098655	cation transmembrane transport
0.48	GO:0010043	response to zinc ion
0.46	GO:0006829	zinc II ion transport
0.44	GO:0097501	stress response to metal ion
0.44	GO:0006882	cellular zinc ion homeostasis
0.43	GO:0061088	regulation of sequestering of zinc ion
0.40	GO:0098660	inorganic ion transmembrane transport
0.39	GO:0098754	detoxification
0.35	GO:0065009	regulation of molecular function
0.35	GO:0006334	nucleosome assembly

0.61	GO:0008324	cation transmembrane transporter activity
0.40	GO:0015562	efflux transmembrane transporter activity
0.40	GO:0015318	inorganic molecular entity transmembrane transporter activity
0.37	GO:0019855	calcium channel inhibitor activity
0.34	GO:0008083	growth factor activity
0.34	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.33	GO:0008026	ATP-dependent helicase activity
0.33	GO:0008270	zinc ion binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.43	GO:0016323	basolateral plasma membrane
0.42	GO:0016324	apical plasma membrane
0.35	GO:0005794	Golgi apparatus
0.35	GO:0005783	endoplasmic reticulum
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.34

EC:1.3.1.74

GO:0032440

tr|T1EG87|T1EG87_HELRO
Profilin
Search

0.60

Profilin

0.56

GO:0042989

sequestering of actin monomers

0.74

GO:0003779

actin binding

0.52	GO:0005856	cytoskeleton
0.50	GO:0005938	cell cortex

tr|T1EG88|T1EG88_HELRO
Uncharacterized protein
Search

0.56	Major facilitator superfamily domain-containing protein 1

0.55	GO:0055085	transmembrane transport
0.39	GO:0008643	carbohydrate transport
0.33	GO:0055114	oxidation-reduction process
0.33	GO:0009062	fatty acid catabolic process
0.33	GO:0030258	lipid modification

0.33	GO:0016491	oxidoreductase activity
0.33	GO:0004300	enoyl-CoA hydratase activity
0.32	GO:0004386	helicase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.34	GO:0016507	mitochondrial fatty acid beta-oxidation multienzyme complex
0.30	GO:0016020	membrane

0.33

GO:0016491

tr|T1EG89|T1EG89_HELRO
Uncharacterized protein
Search

0.59	U2 snRNP-associated SURP motif-containing protein (Fragment)

0.61	GO:0006396	RNA processing
0.33	GO:0016071	mRNA metabolic process

0.57	GO:0003723	RNA binding
0.34	GO:0008146	sulfotransferase activity
0.33	GO:0005515	protein binding

0.48	GO:0005654	nucleoplasm
0.30	GO:0044425	membrane part

0.34

EC:2.8.2

GO:0008146

tr|T1EG90|T1EG90_HELRO
Uncharacterized protein
Search

PNPT1

0.42	Polyribonucleotide nucleotidyltransferase

0.75	GO:0006402	mRNA catabolic process
0.63	GO:0006396	RNA processing
0.52	GO:0061013	regulation of mRNA catabolic process
0.51	GO:2000625	regulation of miRNA catabolic process
0.51	GO:0000962	positive regulation of mitochondrial RNA catabolic process
0.51	GO:0035928	rRNA import into mitochondrion
0.51	GO:2000630	positive regulation of miRNA metabolic process
0.51	GO:0000957	mitochondrial RNA catabolic process
0.50	GO:0035927	RNA import into mitochondrion
0.50	GO:0035458	cellular response to interferon-beta

0.79	GO:0004654	polyribonucleotide nucleotidyltransferase activity
0.59	GO:0003723	RNA binding
0.47	GO:0000175	3'-5'-exoribonuclease activity
0.34	GO:0016844	strictosidine synthase activity
0.33	GO:0005515	protein binding

0.50	GO:0045025	mitochondrial degradosome
0.47	GO:0005758	mitochondrial intermembrane space
0.43	GO:0005829	cytosol
0.36	GO:0042788	polysomal ribosome
0.35	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.79	EC:2.7.7.8	GO:0004654
0.34	KEGG:R03738	GO:0016844

tr|T1EG91|T1EG91_HELRO
Uncharacterized protein
Search

FDPS

0.46	Mitochondrial farnesyl diphosphate synthase

0.71	GO:0008299	isoprenoid biosynthetic process
0.43	GO:0045338	farnesyl diphosphate metabolic process
0.38	GO:0008654	phospholipid biosynthetic process
0.35	GO:1902653	secondary alcohol biosynthetic process
0.35	GO:0016126	sterol biosynthetic process
0.35	GO:0033383	geranyl diphosphate metabolic process
0.34	GO:0008203	cholesterol metabolic process
0.34	GO:0008204	ergosterol metabolic process
0.34	GO:0044108	cellular alcohol biosynthetic process
0.34	GO:0016129	phytosteroid biosynthetic process

0.50	GO:0016740	transferase activity
0.33	GO:0046872	metal ion binding

0.35	GO:0005737	cytoplasm
0.34	GO:0005654	nucleoplasm
0.33	GO:0012505	endomembrane system
0.30	GO:0031224	intrinsic component of membrane

0.50

GO:0016740

tr|T1EG92|T1EG92_HELRO
Uncharacterized protein
Search

0.71	FYVE, RhoGEF and PH domain-containing protein 4

0.75	GO:0035023	regulation of Rho protein signal transduction
0.64	GO:0065009	regulation of molecular function
0.53	GO:0046847	filopodium assembly
0.47	GO:0030036	actin cytoskeleton organization
0.46	GO:0008360	regulation of cell shape
0.41	GO:0030035	microspike assembly
0.40	GO:0030032	lamellipodium assembly
0.39	GO:0046330	positive regulation of JNK cascade
0.36	GO:0007254	JNK cascade
0.34	GO:0043065	positive regulation of apoptotic process

0.76	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.52	GO:0046872	metal ion binding
0.37	GO:1901981	phosphatidylinositol phosphate binding
0.35	GO:0003779	actin binding
0.34	GO:0032403	protein complex binding

0.52	GO:0031252	cell leading edge
0.49	GO:0120025	plasma membrane bounded cell projection
0.46	GO:0005794	Golgi apparatus
0.37	GO:0005769	early endosome
0.36	GO:0005856	cytoskeleton
0.34	GO:0005634	nucleus
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

tr|T1EG93|T1EG93_HELRO
Uncharacterized protein
Search

UBE3B

0.78	Ubiquitin-protein ligase E3B

0.73	GO:0016567	protein ubiquitination
0.33	GO:0008299	isoprenoid biosynthetic process
0.32	GO:0016310	phosphorylation

0.74	GO:0004842	ubiquitin-protein transferase activity
0.52	GO:0016874	ligase activity
0.42	GO:0061659	ubiquitin-like protein ligase activity
0.34	GO:0004496	mevalonate kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.35	GO:0005737	cytoplasm
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.52	EC:6	GO:0016874
0.74	KEGG:R03876	GO:0004842

tr|T1EG94|T1EG94_HELRO
Uncharacterized protein
Search

RPS27A

0.62	Epididymis luminal protein 112

0.59	GO:0006518	peptide metabolic process
0.59	GO:0043604	amide biosynthetic process
0.55	GO:0044267	cellular protein metabolic process
0.53	GO:1901566	organonitrogen compound biosynthetic process
0.53	GO:0010467	gene expression
0.52	GO:0009059	macromolecule biosynthetic process
0.36	GO:0006301	postreplication repair
0.35	GO:0035635	entry of bacterium into host cell
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0035666	TRIF-dependent toll-like receptor signaling pathway

0.63	GO:0003735	structural constituent of ribosome
0.36	GO:0046872	metal ion binding
0.33	GO:0043546	molybdopterin cofactor binding
0.33	GO:0003723	RNA binding
0.33	GO:0050660	flavin adenine dinucleotide binding
0.33	GO:0005515	protein binding
0.33	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors

0.61	GO:0005840	ribosome
0.49	GO:0043209	myelin sheath
0.45	GO:0044445	cytosolic part
0.40	GO:0044446	intracellular organelle part
0.36	GO:0005634	nucleus
0.36	GO:0070013	intracellular organelle lumen
0.35	GO:0070062	extracellular exosome
0.34	GO:0030139	endocytic vesicle
0.34	GO:0012506	vesicle membrane
0.34	GO:0005768	endosome

0.33

EC:1.1

GO:0016614

tr|T1EG95|T1EG95_HELRO
Uncharacterized protein
Search

MGAT5

0.95	Mannoside acetylglucosaminyltransferase 5

0.80	GO:0006487	protein N-linked glycosylation
0.48	GO:0070658	neuromast hair cell differentiation involved in neuromast regeneration
0.34	GO:0006516	glycoprotein catabolic process
0.33	GO:0045454	cell redox homeostasis

0.86

GO:0030144

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

0.49	GO:0005794	Golgi apparatus
0.36	GO:0098588	bounding membrane of organelle
0.36	GO:0031984	organelle subcompartment
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.86

EC:2.4.1.155

GO:0030144

tr|T1EG96|T1EG96_HELRO
Uncharacterized protein
Search

SHOC2

0.78	Leucine-rich repeat protein SHOC-2

0.83	GO:0046579	positive regulation of Ras protein signal transduction
0.64	GO:0007265	Ras protein signal transduction
0.62	GO:0043666	regulation of phosphoprotein phosphatase activity
0.39	GO:0008543	fibroblast growth factor receptor signaling pathway
0.38	GO:0006470	protein dephosphorylation

0.84	GO:0019903	protein phosphatase binding
0.63	GO:0019888	protein phosphatase regulator activity
0.38	GO:0004721	phosphoprotein phosphatase activity

0.84	GO:0000164	protein phosphatase type 1 complex
0.67	GO:0005654	nucleoplasm
0.65	GO:0005829	cytosol
0.47	GO:0005886	plasma membrane

0.38

EC:3.1.3.16

GO:0004721

tr|T1EG97|T1EG97_HELRO
Uncharacterized protein
Search

0.54	Arrestin N and Arrestin C domain containing prote in

0.61	GO:0007165	signal transduction
0.35	GO:0051260	protein homooligomerization
0.34	GO:0006468	protein phosphorylation

0.34	GO:0004672	protein kinase activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.30

GO:0031224

intrinsic component of membrane

tr|T1EG98|T1EG98_HELRO
Uncharacterized protein
Search

ABHD4

0.88	Abhydrolase domain-containing protein 4

0.41	GO:0070291	N-acylethanolamine metabolic process
0.35	GO:0016042	lipid catabolic process
0.32	GO:0009058	biosynthetic process

0.49	GO:0016787	hydrolase activity
0.42	GO:0016746	transferase activity, transferring acyl groups

0.35	GO:0042579	microbody
0.30	GO:0044425	membrane part

0.49

GO:0016787

tr|T1EG99|T1EG99_HELRO
Uncharacterized protein
Search

0.91	Guanine nucleotide-binding protein subunit beta-5

0.61	GO:0007165	signal transduction
0.42	GO:0007610	behavior
0.40	GO:0060047	heart contraction
0.40	GO:0043051	regulation of pharyngeal pumping
0.40	GO:0032094	response to food
0.40	GO:0046662	regulation of oviposition
0.39	GO:1905145	cellular response to acetylcholine
0.39	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.38	GO:0009416	response to light stimulus
0.38	GO:0040012	regulation of locomotion

0.37	GO:0031682	G-protein gamma-subunit binding
0.35	GO:0004402	histone acetyltransferase activity
0.35	GO:0004871	signal transducer activity
0.35	GO:0051087	chaperone binding
0.35	GO:0005096	GTPase activator activity
0.35	GO:0032794	GTPase activating protein binding

0.39	GO:0044297	cell body
0.39	GO:0097458	neuron part
0.36	GO:0097731	9+0 non-motile cilium
0.36	GO:0043209	myelin sheath
0.35	GO:0044441	ciliary part
0.34	GO:0005829	cytosol
0.34	GO:1905360	GTPase complex
0.34	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.34	GO:0005634	nucleus
0.33	GO:0098797	plasma membrane protein complex

0.35

GO:0004402

tr|T1EGA0|T1EGA0_HELRO
Uncharacterized protein
Search

0.58	ATP binding cassette subfamily C member 3

0.62	GO:0015711	organic anion transport
0.55	GO:0055085	transmembrane transport
0.44	GO:0042908	xenobiotic transport
0.42	GO:0042221	response to chemical
0.40	GO:0055070	copper ion homeostasis
0.40	GO:0099039	sphingolipid translocation
0.39	GO:0071495	cellular response to endogenous stimulus
0.37	GO:0051716	cellular response to stimulus
0.37	GO:0015748	organophosphate ester transport
0.36	GO:0006813	potassium ion transport

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.64	GO:0008514	organic anion transmembrane transporter activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0042910	xenobiotic transmembrane transporter activity
0.42	GO:0015238	drug transmembrane transporter activity
0.40	GO:0046623	sphingolipid-translocating ATPase activity
0.39	GO:0005507	copper ion binding
0.38	GO:0008281	sulfonylurea receptor activity

0.61	GO:0005887	integral component of plasma membrane
0.48	GO:0098590	plasma membrane region
0.42	GO:0045177	apical part of cell
0.41	GO:0046581	intercellular canaliculus
0.38	GO:0009986	cell surface

0.38

EC:3.6.3.1

GO:0004012

tr|T1EGA1|T1EGA1_HELRO
Uncharacterized protein
Search

0.69	Casein kinase I

0.63	GO:0006468	protein phosphorylation
0.42	GO:0018209	peptidyl-serine modification
0.42	GO:2000052	positive regulation of non-canonical Wnt signaling pathway
0.42	GO:0032922	circadian regulation of gene expression
0.42	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.41	GO:0042752	regulation of circadian rhythm
0.41	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.39	GO:0016055	Wnt signaling pathway
0.39	GO:0030178	negative regulation of Wnt signaling pathway
0.38	GO:1903827	regulation of cellular protein localization

0.67	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0045296	cadherin binding
0.35	GO:0050321	tau-protein kinase activity
0.33	GO:0004930	G-protein coupled receptor activity
0.33	GO:0008270	zinc ion binding
0.32	GO:0003676	nucleic acid binding

0.38	GO:0005634	nucleus
0.37	GO:0005794	Golgi apparatus
0.36	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0005819	spindle
0.36	GO:0005815	microtubule organizing center
0.36	GO:0030529	intracellular ribonucleoprotein complex
0.35	GO:0005874	microtubule
0.34	GO:0098588	bounding membrane of organelle
0.34	GO:0030426	growth cone
0.34	GO:0031984	organelle subcompartment

0.67

GO:0004674

tr|T1EGA2|T1EGA2_HELRO
Uncharacterized protein
Search

0.76	UDP-glucose glycoprotein glucosyltransferase 1

0.85	GO:0097359	UDP-glucosylation
0.74	GO:0006486	protein glycosylation
0.46	GO:0071712	ER-associated misfolded protein catabolic process
0.46	GO:0018196	peptidyl-asparagine modification
0.45	GO:0030968	endoplasmic reticulum unfolded protein response
0.45	GO:0051084	'de novo' posttranslational protein folding
0.35	GO:0098655	cation transmembrane transport
0.35	GO:1904380	endoplasmic reticulum mannose trimming
0.32	GO:0016310	phosphorylation

0.85	GO:0003980	UDP-glucose:glycoprotein glucosyltransferase activity
0.45	GO:0051082	unfolded protein binding
0.35	GO:0008324	cation transmembrane transporter activity
0.32	GO:0016301	kinase activity

0.47	GO:0005783	endoplasmic reticulum
0.41	GO:0005635	nuclear envelope
0.39	GO:0043234	protein complex
0.35	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.34	GO:0043233	organelle lumen
0.34	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.85

GO:0003980

tr|T1EGA3|T1EGA3_HELRO
Uncharacterized protein
Search

0.72	Pleckstrin domain-containing protein 2

0.65	GO:0035023	regulation of Rho protein signal transduction
0.57	GO:0065009	regulation of molecular function
0.47	GO:0016601	Rac protein signal transduction
0.45	GO:0033623	regulation of integrin activation
0.45	GO:0071800	podosome assembly
0.44	GO:0016322	neuron remodeling
0.44	GO:0030316	osteoclast differentiation
0.43	GO:0071526	semaphorin-plexin signaling pathway
0.43	GO:0022405	hair cycle process
0.42	GO:0031532	actin cytoskeleton reorganization

0.65	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.64	GO:0008092	cytoskeletal protein binding
0.44	GO:0048365	Rac GTPase binding
0.37	GO:0050811	GABA receptor binding
0.32	GO:0003676	nucleic acid binding

0.69	GO:0005856	cytoskeleton
0.35	GO:0005737	cytoplasm
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1EGA4|T1EGA4_HELRO
Uncharacterized protein
Search

0.79	Putative polyadenylation factor i complex subunit pfs2 (Fragment)

0.65	GO:0006379	mRNA cleavage
0.65	GO:0006378	mRNA polyadenylation
0.39	GO:0007166	cell surface receptor signaling pathway
0.39	GO:0006369	termination of RNA polymerase II transcription
0.39	GO:0006301	postreplication repair
0.38	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.38	GO:0007283	spermatogenesis
0.38	GO:0051028	mRNA transport
0.37	GO:0000398	mRNA splicing, via spliceosome
0.37	GO:0006405	RNA export from nucleus

0.39	GO:0004888	transmembrane signaling receptor activity
0.37	GO:0003723	RNA binding

0.77	GO:0001650	fibrillar center
0.69	GO:0005654	nucleoplasm
0.50	GO:0043234	protein complex
0.30	GO:0016020	membrane

tr|T1EGA5|T1EGA5_HELRO
Uncharacterized protein
Search

0.52	RabGAP domain-containing protein, putative

0.68	GO:0043547	positive regulation of GTPase activity
0.68	GO:0031338	regulation of vesicle fusion
0.58	GO:0046907	intracellular transport
0.56	GO:0034613	cellular protein localization
0.55	GO:0015031	protein transport
0.48	GO:0016192	vesicle-mediated transport
0.46	GO:1902017	regulation of cilium assembly
0.40	GO:0006914	autophagy
0.34	GO:0055085	transmembrane transport

0.73	GO:0017137	Rab GTPase binding
0.69	GO:0005096	GTPase activator activity
0.36	GO:0022803	passive transmembrane transporter activity

0.56	GO:0012505	endomembrane system
0.53	GO:0005576	extracellular region
0.49	GO:0005739	mitochondrion
0.48	GO:0005829	cytosol
0.42	GO:0031982	vesicle
0.41	GO:0005776	autophagosome
0.30	GO:0016020	membrane

tr|T1EGA6|T1EGA6_HELRO
Uncharacterized protein
Search

TLN2

0.82

Talin

0.85	GO:0007016	cytoskeletal anchoring at plasma membrane
0.72	GO:0007155	cell adhesion
0.46	GO:0061386	closure of optic fissure
0.44	GO:0055013	cardiac muscle cell development
0.44	GO:0045214	sarcomere organization

0.78	GO:0051015	actin filament binding
0.77	GO:0005200	structural constituent of cytoskeleton

0.83	GO:0001726	ruffle
0.82	GO:0005925	focal adhesion
0.68	GO:0005856	cytoskeleton
0.36	GO:0005916	fascia adherens
0.35	GO:0031256	leading edge membrane
0.35	GO:0031253	cell projection membrane
0.34	GO:0009986	cell surface
0.34	GO:0045202	synapse
0.34	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

tr|T1EGA7|T1EGA7_HELRO
Uncharacterized protein
Search

FXR1

0.77	Fragile X mental retardation, autosomal homolog 1

0.50	GO:0001756	somitogenesis
0.50	GO:0048747	muscle fiber development
0.49	GO:0007519	skeletal muscle tissue development
0.48	GO:0007507	heart development
0.39	GO:0017148	negative regulation of translation
0.36	GO:0097091	synaptic vesicle clustering
0.36	GO:0070142	synaptic vesicle budding
0.36	GO:0090328	regulation of olfactory learning
0.36	GO:0045571	negative regulation of imaginal disc growth
0.36	GO:0050802	circadian sleep/wake cycle, sleep

0.59	GO:0003723	RNA binding
0.35	GO:0043621	protein self-association
0.35	GO:0045182	translation regulator activity
0.34	GO:0042802	identical protein binding
0.34	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0016301	kinase activity
0.33	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0097367	carbohydrate derivative binding

0.41	GO:0005844	polysome
0.37	GO:0005634	nucleus
0.36	GO:0071598	neuronal ribonucleoprotein granule
0.35	GO:0035068	micro-ribonucleoprotein complex
0.35	GO:0043186	P granule
0.35	GO:0043204	perikaryon
0.35	GO:0016442	RISC complex
0.35	GO:0010494	cytoplasmic stress granule
0.35	GO:0098793	presynapse
0.34	GO:0030054	cell junction

0.33

GO:0016773

tr|T1EGA8|T1EGA8_HELRO
Uncharacterized protein
Search

0.73	GO:0006338	chromatin remodeling
0.65	GO:0032392	DNA geometric change
0.61	GO:0006281	DNA repair
0.39	GO:0034728	nucleosome organization
0.39	GO:0006333	chromatin assembly or disassembly
0.39	GO:0032015	regulation of Ran protein signal transduction
0.37	GO:0070870	heterochromatin maintenance involved in chromatin silencing
0.37	GO:0046579	positive regulation of Ras protein signal transduction
0.37	GO:0006323	DNA packaging
0.36	GO:2000616	negative regulation of histone H3-K9 acetylation

0.67	GO:0004003	ATP-dependent DNA helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0003677	DNA binding
0.37	GO:0003682	chromatin binding
0.36	GO:0046872	metal ion binding
0.36	GO:0042393	histone binding
0.36	GO:0070615	nucleosome-dependent ATPase activity
0.36	GO:0140034	methylation-dependent protein binding

0.46	GO:0005634	nucleus
0.42	GO:0031974	membrane-enclosed lumen
0.41	GO:0005829	cytosol
0.40	GO:0044446	intracellular organelle part
0.38	GO:0005886	plasma membrane
0.37	GO:0005694	chromosome
0.35	GO:0031248	protein acetyltransferase complex
0.35	GO:1905368	peptidase complex
0.33	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

tr|T1EGA9|T1EGA9_HELRO
Uncharacterized protein
Search

0.69	T-complex protein subunit alpha

0.69	GO:0006457	protein folding
0.54	GO:0044053	translocation of peptides or proteins into host cell cytoplasm
0.54	GO:0090666	scaRNA localization to Cajal body
0.53	GO:1904869	regulation of protein localization to Cajal body
0.53	GO:2000109	regulation of macrophage apoptotic process
0.53	GO:1904851	positive regulation of establishment of protein localization to telomere
0.52	GO:1904874	positive regulation of telomerase RNA localization to Cajal body
0.52	GO:0051973	positive regulation of telomerase activity
0.51	GO:0032212	positive regulation of telomere maintenance via telomerase
0.51	GO:0007339	binding of sperm to zona pellucida

0.71	GO:0051082	unfolded protein binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0031625	ubiquitin protein ligase binding
0.47	GO:0044183	protein binding involved in protein folding
0.33	GO:0003723	RNA binding

0.53	GO:0005832	chaperonin-containing T-complex
0.52	GO:0002199	zona pellucida receptor complex
0.51	GO:0000242	pericentriolar material
0.50	GO:0001669	acrosomal vesicle
0.50	GO:0005720	nuclear heterochromatin
0.49	GO:0043209	myelin sheath
0.49	GO:0044297	cell body
0.46	GO:0005874	microtubule
0.45	GO:0005794	Golgi apparatus
0.36	GO:0070062	extracellular exosome

tr|T1EGB0|T1EGB0_HELRO
Uncharacterized protein
Search

0.63	GO:0006357	regulation of transcription by RNA polymerase II
0.62	GO:0051726	regulation of cell cycle
0.56	GO:0071277	cellular response to calcium ion
0.56	GO:0001944	vasculature development
0.56	GO:0002573	myeloid leukocyte differentiation
0.54	GO:0009612	response to mechanical stimulus
0.52	GO:0009888	tissue development
0.52	GO:0045893	positive regulation of transcription, DNA-templated
0.51	GO:0001774	microglial cell activation
0.51	GO:0042127	regulation of cell proliferation

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.52	GO:0003713	transcription coactivator activity
0.50	GO:0070412	R-SMAD binding
0.49	GO:0008134	transcription factor binding
0.49	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.47	GO:0031625	ubiquitin protein ligase binding
0.46	GO:0003682	chromatin binding
0.45	GO:0005096	GTPase activator activity
0.45	GO:0042803	protein homodimerization activity

0.58	GO:0035976	transcription factor AP-1 complex
0.50	GO:0000790	nuclear chromatin
0.48	GO:0000791	euchromatin
0.48	GO:0005654	nucleoplasm
0.47	GO:0017053	transcriptional repressor complex
0.35	GO:0005829	cytosol
0.33	GO:0042025	host cell nucleus
0.30	GO:0016020	membrane

tr|T1EGB1|T1EGB1_HELRO
Uncharacterized protein
Search

TTPAL

0.79	Alpha tocopherol transfer protein like

0.46	GO:0043401	steroid hormone mediated signaling pathway
0.40	GO:0006351	transcription, DNA-templated
0.40	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.40	GO:2001141	regulation of RNA biosynthetic process
0.39	GO:0010468	regulation of gene expression
0.38	GO:0030001	metal ion transport
0.37	GO:0072511	divalent inorganic cation transport
0.37	GO:0016579	protein deubiquitination
0.35	GO:0098662	inorganic cation transmembrane transport

0.42	GO:0043565	sequence-specific DNA binding
0.42	GO:0008270	zinc ion binding
0.41	GO:0003700	DNA binding transcription factor activity
0.39	GO:0046873	metal ion transmembrane transporter activity
0.37	GO:0005261	cation channel activity
0.37	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.36	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.35	GO:0001882	nucleoside binding

0.41	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.37

GO:0036459

tr|T1EGB2|T1EGB2_HELRO
Uncharacterized protein
Search

SCMH1

0.80	Sex comb on midleg like 2 (Drosophila)

0.60	GO:0009952	anterior/posterior pattern specification
0.59	GO:0007283	spermatogenesis
0.58	GO:0006338	chromatin remodeling
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.39	GO:0036353	histone H2A-K119 monoubiquitination
0.37	GO:0006915	apoptotic process
0.36	GO:0034613	cellular protein localization

0.64	GO:0010369	chromocenter
0.61	GO:0005634	nucleus
0.39	GO:0043234	protein complex
0.36	GO:0000785	chromatin
0.36	GO:0031974	membrane-enclosed lumen

tr|T1EGB3|T1EGB3_HELRO
Uncharacterized protein
Search

0.79	Ankyrin repeat domain-containing protein 40-like

0.86

GO:0031432

titin binding

tr|T1EGB4|T1EGB4_HELRO
Uncharacterized protein
Search

0.85	Disulfide-isomerase A5

0.69

GO:0045454

cell redox homeostasis

0.63

GO:0016853

isomerase activity

0.30

GO:0005623

cell

0.63

EC:5

GO:0016853

tr|T1EGB5|T1EGB5_HELRO
Cytochrome c heme lyase
Search

0.65	Cytochrome c-type heme lyase

0.41

GO:0018063

cytochrome c-heme linkage

0.85	GO:0004408	holocytochrome-c synthase activity
0.54	GO:0046872	metal ion binding

0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane

0.85

EC:4.4.1.17

GO:0004408

tr|T1EGB6|T1EGB6_HELRO
Uncharacterized protein
Search

0.56

GO:0042060

wound healing

0.38	GO:0030554	adenyl nucleotide binding
0.38	GO:0097367	carbohydrate derivative binding
0.38	GO:0008144	drug binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding

0.30

GO:0044425

membrane part

tr|T1EGB7|T1EGB7_HELRO
Uncharacterized protein
Search

0.10	Putative nuclear protein zap (Fragment)

0.36	GO:0032204	regulation of telomere maintenance
0.36	GO:0000122	negative regulation of transcription by RNA polymerase II
0.34	GO:0006351	transcription, DNA-templated
0.31	GO:0055085	transmembrane transport

0.39	GO:0008157	protein phosphatase 1 binding
0.36	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.34	GO:0005199	structural constituent of cell wall
0.34	GO:0003723	RNA binding

0.61	GO:0005634	nucleus
0.46	GO:0005829	cytosol
0.46	GO:0031974	membrane-enclosed lumen
0.42	GO:0044446	intracellular organelle part
0.34	GO:0032040	small-subunit processome
0.30	GO:0031224	intrinsic component of membrane

tr|T1EGB8|T1EGB8_HELRO
Uncharacterized protein
Search

tr|T1EGB9|T1EGB9_HELRO
Uncharacterized protein
Search

DGAT2

0.50	Diacylglycerol o-acyltransferase

0.54	GO:0035356	cellular triglyceride homeostasis
0.54	GO:0071400	cellular response to oleic acid
0.53	GO:0060613	fat pad development
0.53	GO:0046339	diacylglycerol metabolic process
0.53	GO:0034383	low-density lipoprotein particle clearance
0.53	GO:0055089	fatty acid homeostasis
0.52	GO:0035336	long-chain fatty-acyl-CoA metabolic process
0.52	GO:0046460	neutral lipid biosynthetic process
0.51	GO:0019915	lipid storage
0.51	GO:0006641	triglyceride metabolic process

0.64	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
0.47	GO:0042803	protein homodimerization activity
0.32	GO:0003676	nucleic acid binding

0.51	GO:0005811	lipid droplet
0.48	GO:0048471	perinuclear region of cytoplasm
0.48	GO:0030176	integral component of endoplasmic reticulum membrane
0.42	GO:0005739	mitochondrion

0.64

GO:0016747

tr|T1EGC0|T1EGC0_HELRO
Uncharacterized protein
Search

RPL32

0.47	Ribosomal protein 49

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process

0.64	GO:0003735	structural constituent of ribosome
0.33	GO:0008270	zinc ion binding
0.32	GO:0003676	nucleic acid binding

0.61	GO:0005840	ribosome
0.43	GO:0000228	nuclear chromosome
0.43	GO:0005730	nucleolus
0.41	GO:0044445	cytosolic part
0.40	GO:0005844	polysome
0.30	GO:0031224	intrinsic component of membrane

tr|T1EGC1|T1EGC1_HELRO
Uncharacterized protein
Search

tr|T1EGC2|T1EGC2_HELRO
Uncharacterized protein
Search

0.61	regulating synaptic membrane exocytosis protein 3-like

0.59	GO:0006887	exocytosis
0.59	GO:0006886	intracellular protein transport
0.54	GO:0070073	clustering of voltage-gated calcium channels
0.51	GO:0007274	neuromuscular synaptic transmission
0.50	GO:0048167	regulation of synaptic plasticity
0.46	GO:0048489	synaptic vesicle transport
0.46	GO:0099504	synaptic vesicle cycle
0.46	GO:0099643	signal release from synapse
0.46	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.44	GO:0006836	neurotransmitter transport

0.75	GO:0017137	Rab GTPase binding
0.50	GO:0046872	metal ion binding
0.36	GO:0044325	ion channel binding
0.34	GO:0004421	hydroxymethylglutaryl-CoA synthase activity

0.65	GO:0048786	presynaptic active zone
0.46	GO:0099569	presynaptic cytoskeleton
0.45	GO:0008021	synaptic vesicle
0.44	GO:0099738	cell cortex region
0.43	GO:0030863	cortical cytoskeleton
0.30	GO:0016020	membrane

0.34	EC:2.3.3.10	GO:0004421
0.34	KEGG:R01978	GO:0004421

tr|T1EGC3|T1EGC3_HELRO
Uncharacterized protein
Search

PGP

0.27	Phosphoglycolate phosphatase

0.53	GO:0016311	dephosphorylation
0.36	GO:0046196	4-nitrophenol catabolic process
0.35	GO:0044262	cellular carbohydrate metabolic process
0.35	GO:0036211	protein modification process
0.34	GO:0044267	cellular protein metabolic process
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:0010468	regulation of gene expression

0.53	GO:0016791	phosphatase activity
0.35	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0046983	protein dimerization activity
0.32	GO:0046872	metal ion binding
0.32	GO:0016740	transferase activity

0.36	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.53

EC:3.1.3 EC:3.1.3.41

GO:0016791

tr|T1EGC4|T1EGC4_HELRO
Uncharacterized protein
Search

0.60	GO:0034063	stress granule assembly
0.40	GO:0045571	negative regulation of imaginal disc growth
0.40	GO:0008069	dorsal/ventral axis specification, ovarian follicular epithelium
0.40	GO:0016318	ommatidial rotation
0.39	GO:0001752	compound eye photoreceptor fate commitment
0.38	GO:0007265	Ras protein signal transduction
0.37	GO:0010628	positive regulation of gene expression

0.59

GO:0003723

RNA binding

0.42	GO:0005829	cytosol
0.40	GO:0030529	intracellular ribonucleoprotein complex

tr|T1EGC5|T1EGC5_HELRO
Uncharacterized protein
Search

0.54	GO:2000786	positive regulation of autophagosome assembly
0.52	GO:0000045	autophagosome assembly
0.50	GO:0009267	cellular response to starvation
0.35	GO:0016310	phosphorylation
0.32	GO:0046513	ceramide biosynthetic process
0.32	GO:0007018	microtubule-based movement
0.31	GO:0065009	regulation of molecular function

0.35	GO:0016301	kinase activity
0.34	GO:0003723	RNA binding
0.32	GO:0047493	ceramide cholinephosphotransferase activity
0.32	GO:0033188	sphingomyelin synthase activity
0.32	GO:0005246	calcium channel regulator activity
0.32	GO:0003777	microtubule motor activity
0.32	GO:0008017	microtubule binding
0.32	GO:0003779	actin binding
0.31	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding

0.50	GO:0005770	late endosome
0.50	GO:0005802	trans-Golgi network
0.50	GO:0005764	lysosome
0.45	GO:0005887	integral component of plasma membrane
0.37	GO:0070062	extracellular exosome
0.35	GO:0098852	lytic vacuole membrane
0.35	GO:0010008	endosome membrane
0.32	GO:0030173	integral component of Golgi membrane
0.32	GO:0030176	integral component of endoplasmic reticulum membrane
0.32	GO:0016459	myosin complex

0.32	EC:2.7.8.3	GO:0047493
0.32	KEGG:R01891	GO:0047493

tr|T1EGC6|T1EGC6_HELRO
Uncharacterized protein
Search

0.77	GO:0006044	N-acetylglucosamine metabolic process
0.54	GO:0005975	carbohydrate metabolic process
0.50	GO:1901072	glucosamine-containing compound catabolic process
0.43	GO:0019262	N-acetylneuraminate catabolic process
0.37	GO:0006048	UDP-N-acetylglucosamine biosynthetic process
0.36	GO:0015991	ATP hydrolysis coupled proton transport

0.79	GO:0008448	N-acetylglucosamine-6-phosphate deacetylase activity
0.51	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding
0.34	GO:0015078	hydrogen ion transmembrane transporter activity

0.43	GO:0005634	nucleus
0.36	GO:0033179	proton-transporting V-type ATPase, V0 domain
0.35	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.79

EC:3.5.1.25

GO:0008448

tr|T1EGC7|T1EGC7_HELRO
Uncharacterized protein
Search

0.61

Cyclin A

0.45	GO:0016572	histone phosphorylation
0.45	GO:0000086	G2/M transition of mitotic cell cycle
0.45	GO:0044843	cell cycle G1/S phase transition
0.44	GO:0007265	Ras protein signal transduction
0.43	GO:0051726	regulation of cell cycle
0.42	GO:0048522	positive regulation of cellular process
0.42	GO:0010557	positive regulation of macromolecule biosynthetic process
0.42	GO:0010628	positive regulation of gene expression
0.41	GO:0051173	positive regulation of nitrogen compound metabolic process
0.41	GO:0060041	retina development in camera-type eye

0.45	GO:0097472	cyclin-dependent protein kinase activity
0.43	GO:0019901	protein kinase binding
0.43	GO:0019904	protein domain specific binding
0.37	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.34	GO:0030246	carbohydrate binding
0.34	GO:0016757	transferase activity, transferring glycosyl groups

0.61	GO:0005634	nucleus
0.47	GO:0097124	cyclin A2-CDK2 complex
0.41	GO:0005829	cytosol
0.40	GO:0031974	membrane-enclosed lumen
0.39	GO:0045170	spectrosome
0.38	GO:0044446	intracellular organelle part
0.37	GO:0097123	cyclin A1-CDK2 complex
0.35	GO:0005794	Golgi apparatus
0.34	GO:0015630	microtubule cytoskeleton
0.30	GO:0016020	membrane

0.37

GO:0016538

tr|T1EGC8|T1EGC8_HELRO
Uncharacterized protein
Search

ILKAP

0.81	Integrin-linked kinase-associated serine/threonine phosphatase

0.72	GO:0006470	protein dephosphorylation
0.61	GO:0007229	integrin-mediated signaling pathway
0.47	GO:0016310	phosphorylation
0.35	GO:0007018	microtubule-based movement
0.35	GO:0033262	regulation of nuclear cell cycle DNA replication
0.34	GO:0000956	nuclear-transcribed mRNA catabolic process
0.34	GO:0009086	methionine biosynthetic process
0.33	GO:0000398	mRNA splicing, via spliceosome
0.33	GO:0032259	methylation
0.32	GO:0006351	transcription, DNA-templated

0.76	GO:0004722	protein serine/threonine phosphatase activity
0.52	GO:0046872	metal ion binding
0.49	GO:0016301	kinase activity
0.36	GO:0005515	protein binding
0.35	GO:0003777	microtubule motor activity
0.34	GO:0008705	methionine synthase activity
0.34	GO:0031419	cobalamin binding
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.46	GO:0005654	nucleoplasm
0.45	GO:0005829	cytosol
0.32	GO:1990904	ribonucleoprotein complex
0.30	GO:0031224	intrinsic component of membrane

0.34	EC:2.1.1.13	GO:0008705
0.34	KEGG:R00946	GO:0008705

tr|T1EGC9|T1EGC9_HELRO
Uncharacterized protein
Search

SLC12A2

0.75	Bumetanide-sensitive sodium-(Potassium)-chloride cotransporter

0.75	GO:1902476	chloride transmembrane transport
0.48	GO:0070634	transepithelial ammonium transport
0.48	GO:0030321	transepithelial chloride transport
0.45	GO:0072488	ammonium transmembrane transport
0.40	GO:0045795	positive regulation of cell volume
0.39	GO:0060763	mammary duct terminal end bud growth
0.39	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
0.39	GO:0060444	branching involved in mammary gland duct morphogenesis
0.38	GO:0007214	gamma-aminobutyric acid signaling pathway
0.38	GO:0035264	multicellular organism growth

0.83	GO:0015377	cation:chloride symporter activity
0.45	GO:0008519	ammonium transmembrane transporter activity
0.44	GO:0019901	protein kinase binding
0.33	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.43	GO:0016324	apical plasma membrane
0.40	GO:0070062	extracellular exosome
0.40	GO:0016323	basolateral plasma membrane
0.30	GO:0016021	integral component of membrane

0.33

GO:0004553

tr|T1EGD0|T1EGD0_HELRO
Uncharacterized protein
Search

0.34	GO:0006397	mRNA processing
0.34	GO:0090501	RNA phosphodiester bond hydrolysis
0.34	GO:0006665	sphingolipid metabolic process
0.34	GO:0006468	protein phosphorylation
0.33	GO:0006869	lipid transport
0.32	GO:0007165	signal transduction

0.42	GO:0008289	lipid binding
0.34	GO:0004540	ribonuclease activity
0.34	GO:0004672	protein kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.42	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane

tr|T1EGD1|T1EGD1_HELRO
Uncharacterized protein
Search

0.67	Nicotinic acetylcholine receptor alpha 3 subunit

0.79	GO:0060079	excitatory postsynaptic potential
0.60	GO:0034220	ion transmembrane transport
0.41	GO:0007271	synaptic transmission, cholinergic
0.40	GO:0006937	regulation of muscle contraction
0.39	GO:0046662	regulation of oviposition
0.39	GO:1902656	calcium ion import into cytosol
0.38	GO:0098739	import across plasma membrane
0.38	GO:0032501	multicellular organismal process
0.37	GO:0051971	positive regulation of transmission of nerve impulse
0.37	GO:0040012	regulation of locomotion

0.82	GO:0022848	acetylcholine-gated cation-selective channel activity
0.70	GO:0099600	transmembrane receptor activity
0.37	GO:0042166	acetylcholine binding
0.35	GO:0046982	protein heterodimerization activity
0.34	GO:0008146	sulfotransferase activity
0.34	GO:0003777	microtubule motor activity
0.34	GO:0008017	microtubule binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.78	GO:0045211	postsynaptic membrane
0.73	GO:0030054	cell junction
0.39	GO:0005892	acetylcholine-gated channel complex
0.38	GO:0031594	neuromuscular junction
0.36	GO:0043005	neuron projection

0.34

EC:2.8.2

GO:0008146

tr|T1EGD2|T1EGD2_HELRO
Uncharacterized protein
Search

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.47	GO:1902679	negative regulation of RNA biosynthetic process

0.51	GO:0003714	transcription corepressor activity
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005634	nucleus
0.47	GO:0000785	chromatin
0.45	GO:0031974	membrane-enclosed lumen
0.43	GO:1902494	catalytic complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1EGD3|T1EGD3_HELRO
Uncharacterized protein
Search

0.63	Breakpoint cluster region protein (Fragment)

0.76	GO:0043547	positive regulation of GTPase activity
0.75	GO:0035023	regulation of Rho protein signal transduction
0.61	GO:0007165	signal transduction
0.53	GO:0006468	protein phosphorylation
0.49	GO:0043314	negative regulation of neutrophil degranulation
0.49	GO:0060313	negative regulation of blood vessel remodeling
0.48	GO:0060268	negative regulation of respiratory burst
0.48	GO:0002692	negative regulation of cellular extravasation
0.47	GO:0043114	regulation of vascular permeability
0.47	GO:0060216	definitive hemopoiesis

0.76	GO:0005096	GTPase activator activity
0.75	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.57	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0004713	protein tyrosine kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0008144	drug binding

0.46	GO:0014069	postsynaptic density
0.43	GO:0005622	intracellular
0.39	GO:0043234	protein complex
0.38	GO:0005886	plasma membrane
0.35	GO:0070062	extracellular exosome
0.34	GO:0030054	cell junction
0.30	GO:0044425	membrane part

0.57

GO:0004674

tr|T1EGD4|T1EGD4_HELRO
DNA (cytosine-5)-methyltransferase
Search

0.41	Eukaryotic translation initiation factor 3 subunit G

0.79	GO:0090116	C-5 methylation of cytosine
0.51	GO:0090309	positive regulation of methylation-dependent chromatin silencing
0.50	GO:0035622	intrahepatic bile duct development
0.50	GO:1901538	changes to DNA methylation involved in embryo development
0.50	GO:0010216	maintenance of DNA methylation
0.50	GO:0051573	negative regulation of histone H3-K9 methylation
0.49	GO:0051567	histone H3-K9 methylation
0.49	GO:0051571	positive regulation of histone H3-K4 methylation
0.49	GO:0031017	exocrine pancreas development
0.49	GO:0044030	regulation of DNA methylation

0.79	GO:0003886	DNA (cytosine-5-)-methyltransferase activity
0.76	GO:0003682	chromatin binding
0.62	GO:0008270	zinc ion binding
0.54	GO:0003677	DNA binding
0.40	GO:0003723	RNA binding
0.37	GO:1901265	nucleoside phosphate binding
0.37	GO:0036094	small molecule binding
0.34	GO:0038036	sphingosine-1-phosphate receptor activity
0.34	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.48	GO:0005721	pericentric heterochromatin
0.44	GO:0005657	replication fork
0.34	GO:0016282	eukaryotic 43S preinitiation complex
0.34	GO:0033290	eukaryotic 48S preinitiation complex
0.34	GO:0005852	eukaryotic translation initiation factor 3 complex
0.34	GO:0070013	intracellular organelle lumen
0.33	GO:0043025	neuronal cell body
0.30	GO:0016020	membrane

0.79

EC:2.1.1.37

GO:0003886

tr|T1EGD5|T1EGD5_HELRO
Uncharacterized protein
Search

POLK

0.66	DNA polymerase kappa

0.67	GO:0071897	DNA biosynthetic process
0.65	GO:0006281	DNA repair
0.52	GO:0034644	cellular response to UV
0.38	GO:0009792	embryo development ending in birth or egg hatching
0.37	GO:0000003	reproduction
0.35	GO:0006260	DNA replication
0.33	GO:0018342	protein prenylation
0.33	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.33	GO:0007165	signal transduction

0.72	GO:0003684	damaged DNA binding
0.70	GO:0003887	DNA-directed DNA polymerase activity
0.33	GO:0008318	protein prenyltransferase activity
0.33	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.52	GO:0090734	site of DNA damage
0.49	GO:0016604	nuclear body
0.30	GO:0031224	intrinsic component of membrane

0.70

GO:0003887

tr|T1EGD6|T1EGD6_HELRO
Uncharacterized protein
Search

0.78	MYC induced nuclear antigen

0.60	GO:0070544	histone H3-K36 demethylation
0.59	GO:0034720	histone H3-K4 demethylation
0.58	GO:0032259	methylation
0.56	GO:0030961	peptidyl-arginine hydroxylation
0.51	GO:0045668	negative regulation of osteoblast differentiation
0.50	GO:0006338	chromatin remodeling
0.50	GO:0045892	negative regulation of transcription, DNA-templated
0.40	GO:0055114	oxidation-reduction process
0.39	GO:0006351	transcription, DNA-templated
0.34	GO:0042254	ribosome biogenesis

0.60	GO:0032453	histone demethylase activity (H3-K4 specific)
0.60	GO:0051864	histone demethylase activity (H3-K36 specific)
0.58	GO:0008168	methyltransferase activity
0.44	GO:0005506	iron ion binding
0.35	GO:0008113	peptide-methionine (S)-S-oxide reductase activity
0.34	GO:0005515	protein binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.48	GO:0005730	nucleolus
0.40	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.60

EC:1.14.11.27

GO:0051864

tr|T1EGD7|T1EGD7_HELRO
Uncharacterized protein
Search

SACM1L

0.87	SAC1 like phosphatidylinositide phosphatase a

0.52	GO:0046856	phosphatidylinositol dephosphorylation
0.37	GO:0046664	dorsal closure, amnioserosa morphology change
0.36	GO:0060074	synapse maturation
0.36	GO:0016199	axon midline choice point recognition
0.36	GO:0046329	negative regulation of JNK cascade
0.36	GO:0008088	axo-dendritic transport
0.36	GO:0031122	cytoplasmic microtubule organization
0.34	GO:0006661	phosphatidylinositol biosynthetic process
0.34	GO:0045892	negative regulation of transcription, DNA-templated

0.68	GO:0042578	phosphoric ester hydrolase activity
0.33	GO:0005515	protein binding
0.32	GO:0046872	metal ion binding

0.54	GO:0032281	AMPA glutamate receptor complex
0.47	GO:0005794	Golgi apparatus
0.39	GO:0005789	endoplasmic reticulum membrane
0.36	GO:0071683	sensory dendrite
0.35	GO:0043025	neuronal cell body
0.35	GO:0030424	axon
0.34	GO:0098588	bounding membrane of organelle

0.68

GO:0042578

tr|T1EGD8|T1EGD8_HELRO
Uncharacterized protein
Search

0.92	Conopressin receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.53	GO:0001992	regulation of systemic arterial blood pressure by vasopressin
0.44	GO:0019098	reproductive behavior
0.44	GO:1901652	response to peptide
0.43	GO:0009725	response to hormone
0.42	GO:0071495	cellular response to endogenous stimulus
0.42	GO:0045907	positive regulation of vasoconstriction
0.42	GO:0071310	cellular response to organic substance
0.40	GO:0019722	calcium-mediated signaling
0.39	GO:0018108	peptidyl-tyrosine phosphorylation

0.84	GO:0005000	vasopressin receptor activity
0.45	GO:0042277	peptide binding
0.42	GO:0016500	protein-hormone receptor activity
0.41	GO:0004997	thyrotropin-releasing hormone receptor activity
0.40	GO:0042562	hormone binding
0.39	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.39	GO:0031894	V1A vasopressin receptor binding
0.37	GO:0004984	olfactory receptor activity
0.36	GO:0004222	metalloendopeptidase activity
0.35	GO:0005080	protein kinase C binding

0.52	GO:0005886	plasma membrane
0.36	GO:0031410	cytoplasmic vesicle
0.34	GO:0012505	endomembrane system
0.30	GO:0016021	integral component of membrane

0.39

GO:0004715

tr|T1EGD9|T1EGD9_HELRO
Uncharacterized protein
Search

0.83	UBA-like domain-containing protein 2

tr|T1EGE0|T1EGE0_HELRO
Uncharacterized protein
Search

0.50	GO:0040034	regulation of development, heterochronic
0.45	GO:0006357	regulation of transcription by RNA polymerase II
0.37	GO:0035282	segmentation
0.34	GO:0044268	multicellular organismal protein metabolic process
0.34	GO:0018991	oviposition
0.34	GO:0002119	nematode larval development
0.33	GO:0009792	embryo development ending in birth or egg hatching
0.33	GO:0045892	negative regulation of transcription, DNA-templated

0.51	GO:0003676	nucleic acid binding
0.46	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.37	GO:0046872	metal ion binding

0.37

GO:0005634

nucleus

tr|T1EGE1|T1EGE1_HELRO
Sortilin
Search

0.40

Sortilin

0.43	GO:0051005	negative regulation of lipoprotein lipase activity
0.43	GO:0038180	nerve growth factor signaling pathway
0.42	GO:0048227	plasma membrane to endosome transport
0.42	GO:0048011	neurotrophin TRK receptor signaling pathway
0.42	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
0.42	GO:0045599	negative regulation of fat cell differentiation
0.42	GO:0046323	glucose import
0.42	GO:0008333	endosome to lysosome transport
0.41	GO:0006895	Golgi to endosome transport
0.41	GO:0014902	myotube differentiation

0.43	GO:0030379	neurotensin receptor activity, non-G-protein coupled
0.43	GO:0010465	nerve growth factor receptor activity
0.43	GO:0048406	nerve growth factor binding
0.38	GO:0019899	enzyme binding
0.38	GO:0003887	DNA-directed DNA polymerase activity
0.35	GO:0003677	DNA binding
0.35	GO:1901265	nucleoside phosphate binding
0.34	GO:0036094	small molecule binding

0.72	GO:0005794	Golgi apparatus
0.41	GO:0030140	trans-Golgi network transport vesicle
0.40	GO:0005905	clathrin-coated pit
0.40	GO:0005769	early endosome
0.40	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0030659	cytoplasmic vesicle membrane
0.39	GO:0009986	cell surface
0.38	GO:0005829	cytosol
0.35	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.38

GO:0003887

tr|T1EGE2|T1EGE2_HELRO
Uncharacterized protein
Search

0.42	GO:1903506	regulation of nucleic acid-templated transcription
0.42	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.42	GO:0010468	regulation of gene expression
0.41	GO:0016573	histone acetylation
0.40	GO:0007018	microtubule-based movement
0.38	GO:0043065	positive regulation of apoptotic process
0.37	GO:1902679	negative regulation of RNA biosynthetic process
0.36	GO:0006629	lipid metabolic process
0.34	GO:0006896	Golgi to vacuole transport
0.34	GO:0032456	endocytic recycling

0.47	GO:0003676	nucleic acid binding
0.41	GO:0004402	histone acetyltransferase activity
0.41	GO:0003777	microtubule motor activity
0.41	GO:0008017	microtubule binding
0.40	GO:0003779	actin binding
0.39	GO:0046872	metal ion binding
0.36	GO:0003700	DNA binding transcription factor activity
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding

0.42	GO:0072487	MSL complex
0.41	GO:0016459	myosin complex
0.34	GO:0000938	GARP complex
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.41	EC:2.3.1.48	GO:0004402
0.33	KEGG:R03876	GO:0004842

tr|T1EGE3|T1EGE3_HELRO
Uncharacterized protein
Search

TBC1D16

0.82	Putative ypt/rab-specific gtpase-activating protein gyp7

0.84	GO:0001919	regulation of receptor recycling
0.76	GO:0043547	positive regulation of GTPase activity
0.66	GO:0031338	regulation of vesicle fusion
0.56	GO:0006886	intracellular protein transport
0.44	GO:1902017	regulation of cilium assembly

0.76	GO:0005096	GTPase activator activity
0.63	GO:0017137	Rab GTPase binding

0.78	GO:0005769	early endosome
0.66	GO:0005829	cytosol

tr|T1EGE4|T1EGE4_HELRO
Uncharacterized protein
Search

TDP2

0.87	Tyrosyl-DNA phosphodiesterase

0.70	GO:0006302	double-strand break repair
0.70	GO:0048666	neuron development
0.48	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.37	GO:1903507	negative regulation of nucleic acid-templated transcription
0.37	GO:0007166	cell surface receptor signaling pathway

0.85	GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity
0.85	GO:0036317	tyrosyl-RNA phosphodiesterase activity
0.68	GO:0003697	single-stranded DNA binding
0.68	GO:0030145	manganese ion binding
0.60	GO:0000287	magnesium ion binding
0.48	GO:0004518	nuclease activity
0.42	GO:0042802	identical protein binding
0.38	GO:0003714	transcription corepressor activity

0.79	GO:0016605	PML body
0.78	GO:0016235	aggresome
0.46	GO:0005737	cytoplasm
0.43	GO:0005730	nucleolus

0.48

GO:0004518

tr|T1EGE5|T1EGE5_HELRO
Uncharacterized protein
Search

MYO1E

0.82	Unconventional myosin-Ie

0.74	GO:0007018	microtubule-based movement
0.52	GO:0003094	glomerular filtration
0.51	GO:0032835	glomerulus development
0.49	GO:0035166	post-embryonic hemopoiesis
0.48	GO:0061318	renal filtration cell differentiation
0.48	GO:0035850	epithelial cell differentiation involved in kidney development
0.48	GO:0048008	platelet-derived growth factor receptor signaling pathway
0.48	GO:0001570	vasculogenesis
0.47	GO:0072009	nephron epithelium development
0.46	GO:0002064	epithelial cell development

0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.74	GO:0003779	actin binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0005516	calmodulin binding
0.44	GO:0035091	phosphatidylinositol binding
0.44	GO:0032403	protein complex binding
0.41	GO:0042623	ATPase activity, coupled

0.77	GO:0016459	myosin complex
0.47	GO:0005903	brush border
0.47	GO:0045334	clathrin-coated endocytic vesicle
0.46	GO:0005912	adherens junction
0.45	GO:0005911	cell-cell junction
0.36	GO:0031528	microvillus membrane
0.36	GO:0031941	filamentous actin
0.35	GO:0030864	cortical actin cytoskeleton
0.34	GO:0070062	extracellular exosome
0.34	GO:0005768	endosome

0.34

GO:0004222

tr|T1EGE6|T1EGE6_HELRO
Uncharacterized protein
Search

0.65	GO:0006417	regulation of translation
0.39	GO:2000196	positive regulation of female gonad development
0.39	GO:2000623	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.39	GO:1905936	regulation of germ cell proliferation
0.39	GO:0060282	positive regulation of oocyte development
0.39	GO:0001709	cell fate determination
0.37	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.37	GO:0034249	negative regulation of cellular amide metabolic process
0.36	GO:0032269	negative regulation of cellular protein metabolic process
0.36	GO:2000113	negative regulation of cellular macromolecule biosynthetic process

0.71	GO:0003727	single-stranded RNA binding
0.39	GO:0003730	mRNA 3'-UTR binding
0.38	GO:0048027	mRNA 5'-UTR binding
0.37	GO:0097157	pre-mRNA intronic binding
0.34	GO:0005515	protein binding
0.33	GO:0003743	translation initiation factor activity
0.32	GO:0016875	ligase activity, forming carbon-oxygen bonds
0.32	GO:0140101	catalytic activity, acting on a tRNA
0.32	GO:0046872	metal ion binding

0.40	GO:0043186	P granule
0.36	GO:0005829	cytosol
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.32

EC:6.1

GO:0016875

tr|T1EGE7|T1EGE7_HELRO
Uncharacterized protein
Search

tr|T1EGE8|T1EGE8_HELRO
Protein Wnt
Search

tr|T1EGE9|T1EGE9_HELRO
Xylose isomerase
Search

0.31	Xylose isomerase

0.79	GO:0042732	D-xylose metabolic process
0.72	GO:0006098	pentose-phosphate shunt
0.34	GO:0050832	defense response to fungus
0.33	GO:0042742	defense response to bacterium

0.82	GO:0009045	xylose isomerase activity
0.53	GO:0046872	metal ion binding

0.42	GO:0005737	cytoplasm
0.37	GO:0098805	whole membrane
0.36	GO:0098588	bounding membrane of organelle
0.36	GO:0012505	endomembrane system
0.34	GO:0044446	intracellular organelle part
0.34	GO:0043231	intracellular membrane-bounded organelle
0.33	GO:0048475	coated membrane
0.32	GO:0098796	membrane protein complex
0.30	GO:0016021	integral component of membrane

0.82

EC:5.3.1.5

GO:0009045

tr|T1EGF0|T1EGF0_HELRO
Uncharacterized protein
Search

GAA

0.88	Lysosomal alpha-glucosidase

0.60	GO:0005975	carbohydrate metabolic process
0.56	GO:0043181	vacuolar sequestering
0.55	GO:0002086	diaphragm contraction
0.53	GO:0050884	neuromuscular process controlling posture
0.53	GO:0002026	regulation of the force of heart contraction
0.52	GO:0046716	muscle cell cellular homeostasis
0.52	GO:0060048	cardiac muscle contraction
0.52	GO:0050885	neuromuscular process controlling balance
0.51	GO:0007040	lysosome organization
0.50	GO:0003007	heart morphogenesis

0.69	GO:0030246	carbohydrate binding
0.66	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.32	GO:0003677	DNA binding
0.32	GO:0046872	metal ion binding

0.50	GO:0005764	lysosome
0.38	GO:0098852	lytic vacuole membrane
0.36	GO:0070062	extracellular exosome
0.35	GO:0101003	ficolin-1-rich granule membrane
0.35	GO:0070821	tertiary granule membrane
0.35	GO:0005775	vacuolar lumen
0.33	GO:0005634	nucleus
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.66

GO:0004553

tr|T1EGF1|T1EGF1_HELRO
Uncharacterized protein
Search

EXOSC2

0.71	Exosome component 2

0.53	GO:0071049	nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription
0.52	GO:0071051	polyadenylation-dependent snoRNA 3'-end processing
0.52	GO:0034475	U4 snRNA 3'-end processing
0.51	GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process
0.51	GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.51	GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process
0.51	GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
0.50	GO:0030307	positive regulation of cell growth
0.48	GO:0071034	CUT catabolic process
0.47	GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

0.59	GO:0003723	RNA binding
0.44	GO:0017057	6-phosphogluconolactonase activity
0.42	GO:0004527	exonuclease activity
0.33	GO:0004540	ribonuclease activity
0.33	GO:0005509	calcium ion binding
0.32	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.31	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.80	GO:0000178	exosome (RNase complex)
0.48	GO:0031981	nuclear lumen
0.41	GO:0043232	intracellular non-membrane-bounded organelle
0.40	GO:0044444	cytoplasmic part
0.30	GO:0031224	intrinsic component of membrane

0.44	EC:3.1.1.31	GO:0017057
0.44	KEGG:R02035	GO:0017057

tr|T1EGF2|T1EGF2_HELRO
Uncharacterized protein
Search

0.71

GO:0007186

G-protein coupled receptor signaling pathway

0.72	GO:0004930	G-protein coupled receptor activity
0.49	GO:0001653	peptide receptor activity
0.32	GO:0003676	nucleic acid binding

0.30

GO:0044425

membrane part

tr|T1EGF3|T1EGF3_HELRO
Uncharacterized protein
Search

CEPT1

0.85	Choline/ethanolamine phosphotransferase 1

0.68	GO:0008654	phospholipid biosynthetic process
0.53	GO:0046470	phosphatidylcholine metabolic process
0.49	GO:0045017	glycerolipid biosynthetic process
0.41	GO:1901566	organonitrogen compound biosynthetic process
0.40	GO:0046337	phosphatidylethanolamine metabolic process
0.39	GO:0046469	platelet activating factor metabolic process
0.34	GO:0010469	regulation of receptor activity

0.72	GO:0016780	phosphotransferase activity, for other substituted phosphate groups
0.35	GO:0046872	metal ion binding
0.34	GO:0005179	hormone activity

0.48	GO:0005789	endoplasmic reticulum membrane
0.40	GO:0031965	nuclear membrane
0.33	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

0.72

GO:0016780

tr|T1EGF4|T1EGF4_HELRO
Uncharacterized protein
Search

tr|T1EGF5|T1EGF5_HELRO
Uncharacterized protein
Search

0.75	GO:0043547	positive regulation of GTPase activity
0.49	GO:0031338	regulation of vesicle fusion
0.46	GO:0046907	intracellular transport
0.46	GO:1902018	negative regulation of cilium assembly
0.43	GO:0034613	cellular protein localization
0.42	GO:0015031	protein transport
0.42	GO:0016192	vesicle-mediated transport
0.35	GO:0006850	mitochondrial pyruvate transmembrane transport
0.34	GO:0007298	border follicle cell migration
0.34	GO:0007049	cell cycle

0.76	GO:0005096	GTPase activator activity
0.54	GO:0017137	Rab GTPase binding
0.32	GO:0008270	zinc ion binding

0.46	GO:0012505	endomembrane system
0.42	GO:0005829	cytosol
0.38	GO:0043231	intracellular membrane-bounded organelle
0.34	GO:0005819	spindle
0.34	GO:0005815	microtubule organizing center
0.33	GO:0031410	cytoplasmic vesicle
0.33	GO:0030915	Smc5-Smc6 complex
0.33	GO:0019866	organelle inner membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1EGF6|T1EGF6_HELRO
Uncharacterized protein
Search

0.63	GO:0007275	multicellular organism development
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.47	GO:0034101	erythrocyte homeostasis
0.46	GO:0009653	anatomical structure morphogenesis
0.38	GO:0030154	cell differentiation
0.38	GO:1902679	negative regulation of RNA biosynthetic process
0.35	GO:0006351	transcription, DNA-templated

0.65	GO:0043565	sequence-specific DNA binding
0.56	GO:0003700	DNA binding transcription factor activity
0.33	GO:0003723	RNA binding
0.33	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.41	GO:0031974	membrane-enclosed lumen
0.38	GO:0005829	cytosol
0.38	GO:0015630	microtubule cytoskeleton
0.38	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

tr|T1EGF7|T1EGF7_HELRO
Uncharacterized protein
Search

FLNA

0.57	FLNA protein (Predicted)

0.48	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
0.48	GO:0051764	actin crosslink formation
0.48	GO:0034394	protein localization to cell surface
0.48	GO:0051220	cytoplasmic sequestering of protein
0.48	GO:0042993	positive regulation of transcription factor import into nucleus
0.48	GO:0043113	receptor clustering
0.47	GO:2001046	positive regulation of integrin-mediated signaling pathway
0.47	GO:0042177	negative regulation of protein catabolic process
0.47	GO:0043433	negative regulation of DNA binding transcription factor activity
0.46	GO:0016479	negative regulation of transcription by RNA polymerase I

0.74	GO:0003779	actin binding
0.69	GO:0032403	protein complex binding
0.48	GO:0034987	immunoglobulin receptor binding
0.47	GO:0048365	Rac GTPase binding
0.46	GO:0017160	Ral GTPase binding
0.46	GO:0015459	potassium channel regulator activity
0.45	GO:0044325	ion channel binding
0.44	GO:0045296	cadherin binding
0.44	GO:0001664	G-protein coupled receptor binding
0.43	GO:0019900	kinase binding

0.47	GO:0031523	Myb complex
0.46	GO:0031941	filamentous actin
0.43	GO:0005911	cell-cell junction
0.42	GO:0005730	nucleolus
0.41	GO:0005829	cytosol
0.38	GO:0005886	plasma membrane
0.35	GO:0097440	apical dendrite
0.35	GO:0030018	Z disc
0.35	GO:0043198	dendritic shaft
0.35	GO:0030426	growth cone

0.33

GO:0004713

tr|T1EGF8|T1EGF8_HELRO
Uncharacterized protein
Search

PDXK

0.54	Pyridoxal kinase

0.82	GO:0009443	pyridoxal 5'-phosphate salvage
0.57	GO:0016310	phosphorylation
0.45	GO:0008283	cell proliferation
0.35	GO:0017085	response to insecticide
0.34	GO:0043312	neutrophil degranulation
0.34	GO:0032094	response to food
0.34	GO:0032570	response to progesterone
0.34	GO:0014075	response to amine
0.34	GO:0010165	response to X-ray
0.34	GO:0043066	negative regulation of apoptotic process

0.82	GO:0008478	pyridoxal kinase activity
0.49	GO:0031403	lithium ion binding
0.45	GO:0031402	sodium ion binding
0.44	GO:0030955	potassium ion binding
0.44	GO:0042803	protein homodimerization activity
0.41	GO:0030170	pyridoxal phosphate binding
0.40	GO:0000287	magnesium ion binding
0.40	GO:0008270	zinc ion binding
0.38	GO:0032559	adenyl ribonucleotide binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding

0.42	GO:0005654	nucleoplasm
0.41	GO:0005829	cytosol
0.35	GO:0070062	extracellular exosome
0.35	GO:0035580	specific granule lumen
0.34	GO:0030688	preribosome, small subunit precursor
0.30	GO:0031224	intrinsic component of membrane

0.82

EC:2.7.1.35

GO:0008478

tr|T1EGF9|T1EGF9_HELRO
Uncharacterized protein
Search

WDFY2

0.91	WD repeat and FYVE domain-containing protein 2

0.57	GO:0045600	positive regulation of fat cell differentiation
0.52	GO:0001934	positive regulation of protein phosphorylation
0.35	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway
0.35	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway

0.52	GO:0046872	metal ion binding
0.35	GO:0005545	1-phosphatidylinositol binding
0.34	GO:0005515	protein binding

0.54	GO:0005769	early endosome
0.33	GO:0005829	cytosol
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EGG0|T1EGG0_HELRO
Protein Wnt
Search

0.77	GO:0016055	Wnt signaling pathway
0.70	GO:0007275	multicellular organism development
0.50	GO:0090090	negative regulation of canonical Wnt signaling pathway
0.50	GO:1904934	negative regulation of cell proliferation in midbrain
0.50	GO:0051885	positive regulation of timing of anagen
0.50	GO:0045598	regulation of fat cell differentiation
0.49	GO:0097325	melanocyte proliferation
0.49	GO:1900020	positive regulation of protein kinase C activity
0.49	GO:0048022	negative regulation of melanin biosynthetic process
0.49	GO:0009888	tissue development

0.73	GO:0005102	receptor binding
0.44	GO:0044212	transcription regulatory region DNA binding
0.44	GO:0019904	protein domain specific binding
0.44	GO:0030545	receptor regulator activity
0.40	GO:0140110	transcription regulator activity
0.34	GO:0017147	Wnt-protein binding
0.33	GO:0003785	actin monomer binding
0.33	GO:0002020	protease binding
0.33	GO:0005543	phospholipid binding

0.75	GO:0005578	proteinaceous extracellular matrix
0.46	GO:0009986	cell surface
0.46	GO:0005615	extracellular space
0.35	GO:0005622	intracellular
0.34	GO:0012505	endomembrane system
0.34	GO:0043233	organelle lumen
0.34	GO:1903561	extracellular vesicle
0.33	GO:0012506	vesicle membrane
0.33	GO:0098805	whole membrane
0.33	GO:0098588	bounding membrane of organelle

tr|T1EGG1|T1EGG1_HELRO
Uncharacterized protein
Search

tr|T1EGG2|T1EGG2_HELRO
Uncharacterized protein
Search

PLD3

0.89	Phospholipase D family member 3

0.39	GO:0016042	lipid catabolic process
0.32	GO:0006468	protein phosphorylation

0.42	GO:0004630	phospholipase D activity
0.41	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0005515	protein binding
0.32	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.39	GO:0005789	endoplasmic reticulum membrane
0.35	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.42

EC:3.1.4.4

GO:0004630

tr|T1EGG3|T1EGG3_HELRO
Uncharacterized protein
Search

0.38	Pantothenate kinase

0.75	GO:0015937	coenzyme A biosynthetic process
0.57	GO:0016310	phosphorylation
0.42	GO:0001878	response to yeast
0.38	GO:0048870	cell motility
0.34	GO:0001944	vasculature development
0.34	GO:0007399	nervous system development

0.79	GO:0004594	pantothenate kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005509	calcium ion binding
0.32	GO:0003723	RNA binding
0.32	GO:0016787	hydrolase activity

0.40	GO:0031514	motile cilium
0.34	GO:0055037	recycling endosome
0.34	GO:0030118	clathrin coat
0.33	GO:0005829	cytosol
0.33	GO:0005576	extracellular region
0.33	GO:0005634	nucleus
0.32	GO:0071944	cell periphery
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:2.7.1.33

GO:0004594

tr|T1EGG4|T1EGG4_HELRO
Uncharacterized protein
Search

0.75	GO:0016579	protein deubiquitination
0.69	GO:0006511	ubiquitin-dependent protein catabolic process
0.49	GO:0016570	histone modification
0.49	GO:1902459	positive regulation of stem cell population maintenance
0.48	GO:1900425	negative regulation of defense response to bacterium
0.48	GO:0030718	germ-line stem cell population maintenance
0.48	GO:0035019	somatic stem cell population maintenance
0.48	GO:0031937	positive regulation of chromatin silencing
0.44	GO:0042981	regulation of apoptotic process
0.43	GO:0045824	negative regulation of innate immune response

0.76	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.34	GO:0005515	protein binding
0.33	GO:0005509	calcium ion binding
0.33	GO:0005044	scavenger receptor activity
0.33	GO:0001871	pattern binding
0.33	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
0.32	GO:0030246	carbohydrate binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding

0.44	GO:0005730	nucleolus
0.34	GO:0070701	mucus layer
0.34	GO:0005654	nucleoplasm
0.33	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex
0.32	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

0.76

GO:0036459

tr|T1EGG5|T1EGG5_HELRO
Uncharacterized protein
Search

NUCB1

0.71	EFhand protein NUCB1 [Nasonia vitripennis]

0.40	GO:0072718	response to cisplatin
0.39	GO:1903533	regulation of protein targeting
0.38	GO:0030216	keratinocyte differentiation
0.36	GO:0043687	post-translational protein modification
0.35	GO:0006508	proteolysis
0.34	GO:0005975	carbohydrate metabolic process
0.33	GO:0007267	cell-cell signaling
0.33	GO:0034765	regulation of ion transmembrane transport
0.33	GO:0070588	calcium ion transmembrane transport
0.33	GO:0007186	G-protein coupled receptor signaling pathway

0.69	GO:0005509	calcium ion binding
0.40	GO:0001965	G-protein alpha-subunit binding
0.36	GO:0004181	metallocarboxypeptidase activity
0.35	GO:0003677	DNA binding
0.34	GO:0008270	zinc ion binding
0.33	GO:0005245	voltage-gated calcium channel activity
0.33	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.32	GO:0004871	signal transducer activity
0.32	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding

0.52	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.42	GO:0098547	lumenal side of Golgi membrane
0.40	GO:0090498	extrinsic component of Golgi membrane
0.39	GO:0005801	cis-Golgi network
0.39	GO:0005791	rough endoplasmic reticulum
0.39	GO:0032580	Golgi cisterna membrane
0.38	GO:0005769	early endosome
0.38	GO:0005802	trans-Golgi network
0.38	GO:0001533	cornified envelope
0.38	GO:0005798	Golgi-associated vesicle

0.36

EC:3.4.17

GO:0004181

tr|T1EGG6|T1EGG6_HELRO
Uncharacterized protein
Search

0.48	Endoplasmic reticulum to nucleus signaling 1

0.70	GO:0006397	mRNA processing
0.69	GO:0090501	RNA phosphodiester bond hydrolysis
0.63	GO:0006468	protein phosphorylation
0.44	GO:0036498	IRE1-mediated unfolded protein response
0.42	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation
0.41	GO:1904576	response to tunicamycin
0.41	GO:0061541	rhabdomere morphogenesis
0.40	GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
0.40	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
0.40	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process

0.70	GO:0004540	ribonuclease activity
0.64	GO:0004672	protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0004588	orotate phosphoribosyltransferase activity
0.41	GO:0004590	orotidine-5'-phosphate decarboxylase activity
0.38	GO:0004519	endonuclease activity
0.34	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)

0.36	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0098796	membrane protein complex
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.41	EC:2.4.2.10	GO:0004588
0.41	KEGG:R00965	GO:0004590

tr|T1EGG7|T1EGG7_HELRO
Uncharacterized protein
Search

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.62	GO:0050852	T cell receptor signaling pathway
0.42	GO:0001915	negative regulation of T cell mediated cytotoxicity
0.41	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway
0.41	GO:0042100	B cell proliferation
0.41	GO:0050853	B cell receptor signaling pathway
0.41	GO:0042102	positive regulation of T cell proliferation
0.40	GO:0006469	negative regulation of protein kinase activity
0.40	GO:0051209	release of sequestered calcium ion into cytosol
0.40	GO:0030217	T cell differentiation

0.75	GO:0004725	protein tyrosine phosphatase activity
0.39	GO:0019901	protein kinase binding
0.39	GO:0019198	transmembrane receptor protein phosphatase activity
0.36	GO:0043395	heparan sulfate proteoglycan binding
0.36	GO:0008201	heparin binding
0.35	GO:0005044	scavenger receptor activity
0.35	GO:0033549	MAP kinase phosphatase activity
0.34	GO:0019887	protein kinase regulator activity

0.40	GO:0005925	focal adhesion
0.38	GO:0005887	integral component of plasma membrane
0.37	GO:0009986	cell surface
0.37	GO:0098857	membrane microdomain
0.36	GO:0098552	side of membrane
0.35	GO:0070062	extracellular exosome
0.34	GO:0030667	secretory granule membrane

0.75

GO:0004725

tr|T1EGG8|T1EGG8_HELRO
Uncharacterized protein
Search

TATDN3

0.94	TatD DNase domain containing 3

0.36

GO:0006259

DNA metabolic process

0.61	GO:0016788	hydrolase activity, acting on ester bonds
0.36	GO:0140097	catalytic activity, acting on DNA

0.61

GO:0016788

tr|T1EGG9|T1EGG9_HELRO
Uncharacterized protein
Search

0.55	Zinc transporter

0.61	GO:0098655	cation transmembrane transport
0.38	GO:0006882	cellular zinc ion homeostasis
0.37	GO:0006829	zinc II ion transport
0.36	GO:0045944	positive regulation of transcription by RNA polymerase II
0.30	GO:0008152	metabolic process

0.61	GO:0008324	cation transmembrane transporter activity
0.38	GO:0016922	ligand-dependent nuclear receptor binding
0.37	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
0.36	GO:0003682	chromatin binding
0.34	GO:0008484	sulfuric ester hydrolase activity

0.36	GO:0031410	cytoplasmic vesicle
0.36	GO:0005783	endoplasmic reticulum
0.35	GO:0005856	cytoskeleton
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.34

EC:3.1.6

GO:0008484

tr|T1EGH0|T1EGH0_HELRO
Uncharacterized protein
Search

0.11	Chromodomain-helicase-DNA-binding protein 8

0.49	GO:0021545	cranial nerve development
0.49	GO:0003226	right ventricular compact myocardium morphogenesis
0.48	GO:0042472	inner ear morphogenesis
0.48	GO:0060041	retina development in camera-type eye
0.47	GO:0060123	regulation of growth hormone secretion
0.47	GO:0036302	atrioventricular canal development
0.47	GO:0007512	adult heart development
0.47	GO:0043584	nose development
0.47	GO:0060872	semicircular canal development
0.47	GO:0003222	ventricular trabecula myocardium morphogenesis

0.57	GO:0004386	helicase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0003677	DNA binding
0.46	GO:1990841	promoter-specific chromatin binding
0.43	GO:0001067	regulatory region nucleic acid binding
0.38	GO:0002039	p53 binding
0.38	GO:0008013	beta-catenin binding

0.59	GO:0005634	nucleus
0.42	GO:0070013	intracellular organelle lumen
0.39	GO:0044446	intracellular organelle part
0.38	GO:0043232	intracellular non-membrane-bounded organelle
0.38	GO:0034708	methyltransferase complex
0.30	GO:0016021	integral component of membrane

tr|T1EGH1|T1EGH1_HELRO
Uncharacterized protein
Search

0.47	TWiK family of potassium channels protein 7

0.68	GO:0071805	potassium ion transmembrane transport
0.44	GO:0030322	stabilization of membrane potential
0.36	GO:0042321	negative regulation of circadian sleep/wake cycle, sleep
0.36	GO:0045837	negative regulation of membrane potential
0.36	GO:1903351	cellular response to dopamine
0.33	GO:0032259	methylation
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.71	GO:0005267	potassium channel activity
0.44	GO:0022842	narrow pore channel activity
0.33	GO:0008168	methyltransferase activity
0.32	GO:0003723	RNA binding

0.39	GO:0005887	integral component of plasma membrane
0.33	GO:0005634	nucleus

0.33

GO:0008168

tr|T1EGH2|T1EGH2_HELRO
Uncharacterized protein
Search

0.47	Programmed cell death protein 6

0.38

GO:0006508

proteolysis

0.70	GO:0005509	calcium ion binding
0.44	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.35	GO:0017056	structural constituent of nuclear pore
0.32	GO:0016874	ligase activity

0.35	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016874

tr|T1EGH3|T1EGH3_HELRO
Uncharacterized protein
Search

0.55	GO:0055085	transmembrane transport
0.40	GO:0032981	mitochondrial respiratory chain complex I assembly

0.30

GO:0044425

membrane part

tr|T1EGH4|T1EGH4_HELRO
Uncharacterized protein
Search

TMTC3

0.86	Transmembrane and tetratricopeptide repeat containing 3

0.53	GO:1901800	positive regulation of proteasomal protein catabolic process
0.53	GO:0034976	response to endoplasmic reticulum stress
0.37	GO:0060447	bud outgrowth involved in lung branching
0.37	GO:0048286	lung alveolus development
0.36	GO:0048747	muscle fiber development
0.36	GO:0009791	post-embryonic development
0.33	GO:0010468	regulation of gene expression

0.34	GO:0016740	transferase activity
0.33	GO:0005515	protein binding
0.31	GO:0140096	catalytic activity, acting on a protein

0.48	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane

0.34

GO:0016740

tr|T1EGH5|T1EGH5_HELRO
Uncharacterized protein
Search

0.52	Fructose-1,6-bisphosphatase (inferred by orthology to a C. elegans protein)

0.68	GO:0016311	dephosphorylation
0.60	GO:0005975	carbohydrate metabolic process
0.42	GO:0030388	fructose 1,6-bisphosphate metabolic process
0.41	GO:0006002	fructose 6-phosphate metabolic process
0.37	GO:0044283	small molecule biosynthetic process
0.36	GO:1901576	organic substance biosynthetic process
0.35	GO:0044249	cellular biosynthetic process
0.34	GO:0043413	macromolecule glycosylation
0.34	GO:0009100	glycoprotein metabolic process
0.33	GO:0072593	reactive oxygen species metabolic process

0.79	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity
0.37	GO:0000287	magnesium ion binding
0.35	GO:0003830	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

0.39	GO:0005829	cytosol
0.33	GO:0042597	periplasmic space
0.30	GO:0016020	membrane

0.79

EC:3.1.3.11

GO:0042132

tr|T1EGH6|T1EGH6_HELRO
Uncharacterized protein
Search

0.69	GO:0045454	cell redox homeostasis
0.41	GO:0034976	response to endoplasmic reticulum stress
0.39	GO:0006457	protein folding
0.37	GO:0043277	apoptotic cell clearance
0.34	GO:0006662	glycerol ether metabolic process
0.34	GO:2000427	positive regulation of apoptotic cell clearance
0.34	GO:0055114	oxidation-reduction process
0.34	GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
0.33	GO:0019511	peptidyl-proline hydroxylation
0.33	GO:0006468	protein phosphorylation

0.57	GO:0016853	isomerase activity
0.42	GO:0140096	catalytic activity, acting on a protein
0.37	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors
0.34	GO:0005509	calcium ion binding
0.33	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
0.33	GO:0020037	heme binding
0.33	GO:0005506	iron ion binding
0.33	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.33	GO:0009055	electron transfer activity
0.32	GO:0016301	kinase activity

0.52	GO:0005783	endoplasmic reticulum
0.39	GO:0043233	organelle lumen
0.37	GO:0044446	intracellular organelle part
0.33	GO:0098805	whole membrane
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0019867	outer membrane
0.33	GO:0005739	mitochondrion
0.32	GO:0031975	envelope
0.30	GO:0016021	integral component of membrane

0.57

EC:5

GO:0016853

tr|T1EGH7|T1EGH7_HELRO
Uncharacterized protein
Search

0.10	glycine receptor subunit alpha-4-like

0.61	GO:0007165	signal transduction
0.60	GO:0034220	ion transmembrane transport
0.52	GO:0006821	chloride transport
0.37	GO:0007268	chemical synaptic transmission
0.36	GO:0043200	response to amino acid
0.35	GO:0060078	regulation of postsynaptic membrane potential
0.34	GO:0071773	cellular response to BMP stimulus
0.34	GO:0060828	regulation of canonical Wnt signaling pathway
0.33	GO:0048513	animal organ development
0.33	GO:0006357	regulation of transcription by RNA polymerase II

0.74	GO:0005230	extracellular ligand-gated ion channel activity
0.72	GO:0004890	GABA-A receptor activity
0.38	GO:0099095	ligand-gated anion channel activity
0.37	GO:0005254	chloride channel activity
0.36	GO:0016594	glycine binding
0.36	GO:0022835	transmitter-gated channel activity
0.34	GO:0008066	glutamate receptor activity
0.33	GO:0044877	macromolecular complex binding
0.33	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0005509	calcium ion binding

0.54	GO:0005886	plasma membrane
0.39	GO:1902711	GABA-A receptor complex
0.35	GO:0098794	postsynapse
0.30	GO:0016021	integral component of membrane

0.33

GO:0004674

tr|T1EGH8|T1EGH8_HELRO
Uncharacterized protein
Search

STOM

0.64	Mechanosensory protein 2

0.39	GO:0097206	nephrocyte filtration
0.35	GO:0051260	protein homooligomerization
0.35	GO:1901585	regulation of acid-sensing ion channel activity
0.34	GO:0044829	positive regulation by host of viral genome replication
0.34	GO:0090314	positive regulation of protein targeting to membrane
0.32	GO:0006508	proteolysis

0.35	GO:0070063	RNA polymerase binding
0.33	GO:0042803	protein homodimerization activity
0.32	GO:0008233	peptidase activity

0.47	GO:0005887	integral component of plasma membrane
0.35	GO:0045121	membrane raft
0.35	GO:0005917	nephrocyte diaphragm
0.34	GO:0005783	endoplasmic reticulum
0.34	GO:0042470	melanosome
0.34	GO:0005856	cytoskeleton
0.34	GO:0048471	perinuclear region of cytoplasm
0.33	GO:0005739	mitochondrion

0.32

GO:0008233

tr|T1EGH9|T1EGH9_HELRO
Uncharacterized protein
Search

0.54	PTPRF interacting protein, binding protein 1 (Liprin beta 1)

0.37

GO:0007155

cell adhesion

0.67	GO:0045296	cadherin binding
0.58	GO:0042802	identical protein binding

0.42	GO:0005925	focal adhesion
0.39	GO:0005829	cytosol
0.37	GO:0005615	extracellular space
0.35	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

tr|T1EGI0|T1EGI0_HELRO
Uncharacterized protein
Search

0.30

GO:0044425

membrane part

tr|T1EGI1|T1EGI1_HELRO
Uncharacterized protein
Search

0.44	GNAT family N-acetyltransferase

0.68

GO:0008080

N-acetyltransferase activity

0.68

GO:0008080

tr|T1EGI2|T1EGI2_HELRO
Uncharacterized protein
Search

0.80	Chloride intracellular channel protein 6

0.68	GO:1902476	chloride transmembrane transport
0.65	GO:0051726	regulation of cell cycle
0.64	GO:0034765	regulation of ion transmembrane transport
0.52	GO:0045669	positive regulation of osteoblast differentiation
0.51	GO:0051881	regulation of mitochondrial membrane potential
0.45	GO:0006749	glutathione metabolic process
0.38	GO:0070527	platelet aggregation
0.37	GO:0006468	protein phosphorylation
0.36	GO:0060255	regulation of macromolecule metabolic process
0.36	GO:0031326	regulation of cellular biosynthetic process

0.69	GO:0005254	chloride channel activity
0.62	GO:0022832	voltage-gated channel activity
0.61	GO:0022839	ion gated channel activity
0.60	GO:0008381	mechanosensitive ion channel activity
0.50	GO:0045296	cadherin binding
0.46	GO:0004364	glutathione transferase activity
0.37	GO:0004674	protein serine/threonine kinase activity
0.37	GO:0140110	transcription regulator activity
0.36	GO:0008270	zinc ion binding
0.35	GO:0051087	chaperone binding

0.67	GO:0034707	chloride channel complex
0.50	GO:0070062	extracellular exosome
0.49	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0005635	nuclear envelope
0.48	GO:0036195	muscle cell projection membrane
0.47	GO:0055120	striated muscle dense body
0.45	GO:0005765	lysosomal membrane
0.45	GO:0016324	apical plasma membrane
0.43	GO:0000139	Golgi membrane
0.42	GO:0005739	mitochondrion

0.46

EC:2.5.1.18

GO:0004364

tr|T1EGI3|T1EGI3_HELRO
Uncharacterized protein
Search

0.66	Golgi apparatus protein 1

0.50	GO:0010955	negative regulation of protein processing
0.50	GO:0032330	regulation of chondrocyte differentiation
0.49	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.49	GO:0060349	bone morphogenesis
0.35	GO:0050900	leukocyte migration
0.34	GO:0016311	dephosphorylation

0.45	GO:0017134	fibroblast growth factor binding
0.34	GO:0005102	receptor binding
0.34	GO:0030246	carbohydrate binding
0.34	GO:0016791	phosphatase activity
0.32	GO:0003676	nucleic acid binding

0.74	GO:0000139	Golgi membrane
0.46	GO:0005578	proteinaceous extracellular matrix
0.35	GO:0070062	extracellular exosome
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.34

EC:3.1.3 EC:3.1.3.41

GO:0016791

tr|T1EGI4|T1EGI4_HELRO
Uncharacterized protein
Search

0.79	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit

0.80	GO:0006487	protein N-linked glycosylation
0.42	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity
0.36	GO:0007568	aging
0.35	GO:0042493	response to drug
0.34	GO:0018196	peptidyl-asparagine modification
0.33	GO:0006413	translational initiation
0.33	GO:0007029	endoplasmic reticulum organization
0.33	GO:0051302	regulation of cell division
0.32	GO:0035725	sodium ion transmembrane transport

0.47	GO:0016740	transferase activity
0.44	GO:0051499	D-aminoacyl-tRNA deacylase activity
0.36	GO:0000049	tRNA binding
0.35	GO:0043022	ribosome binding
0.33	GO:0004004	ATP-dependent RNA helicase activity
0.33	GO:0003735	structural constituent of ribosome
0.33	GO:0003743	translation initiation factor activity
0.32	GO:0005515	protein binding
0.32	GO:0005272	sodium channel activity
0.32	GO:0032559	adenyl ribonucleotide binding

0.83	GO:0008250	oligosaccharyltransferase complex
0.37	GO:0000421	autophagosome membrane
0.36	GO:0005791	rough endoplasmic reticulum
0.30	GO:0031224	intrinsic component of membrane

0.47

GO:0016740

tr|T1EGI5|T1EGI5_HELRO
Uncharacterized protein
Search

0.39	GO:1902625	negative regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter
0.37	GO:0006338	chromatin remodeling
0.37	GO:0000398	mRNA splicing, via spliceosome
0.34	GO:0007525	somatic muscle development
0.34	GO:0007162	negative regulation of cell adhesion
0.34	GO:0006417	regulation of translation
0.33	GO:0045944	positive regulation of transcription by RNA polymerase II
0.33	GO:0046854	phosphatidylinositol phosphorylation
0.32	GO:0022900	electron transport chain
0.32	GO:0005975	carbohydrate metabolic process

0.59	GO:0003723	RNA binding
0.53	GO:0046872	metal ion binding
0.35	GO:0045182	translation regulator activity
0.34	GO:0016307	phosphatidylinositol phosphate kinase activity
0.33	GO:0046983	protein dimerization activity
0.33	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.33	GO:0003700	DNA binding transcription factor activity
0.33	GO:0020037	heme binding
0.32	GO:0009055	electron transfer activity
0.32	GO:0003677	DNA binding

0.38	GO:0000932	P-body
0.38	GO:0010494	cytoplasmic stress granule
0.35	GO:0005634	nucleus
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.34

GO:0016307

tr|T1EGI6|T1EGI6_HELRO
Uncharacterized protein
Search

0.83	Adapter molecule Crk

0.71	GO:0046528	imaginal disc fusion
0.68	GO:0007298	border follicle cell migration
0.68	GO:0006911	phagocytosis, engulfment
0.66	GO:0046330	positive regulation of JNK cascade
0.59	GO:0007520	myoblast fusion
0.55	GO:0071538	SH2 domain-mediated complex assembly
0.55	GO:0048013	ephrin receptor signaling pathway
0.52	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
0.52	GO:0032956	regulation of actin cytoskeleton organization
0.51	GO:0061045	negative regulation of wound healing

0.73	GO:0005070	SH3/SH2 adaptor activity
0.52	GO:0042169	SH2 domain binding
0.52	GO:0001784	phosphotyrosine residue binding
0.52	GO:0046875	ephrin receptor binding
0.51	GO:0043621	protein self-association
0.51	GO:1990782	protein tyrosine kinase binding
0.49	GO:0017124	SH3 domain binding
0.37	GO:0017137	Rab GTPase binding
0.36	GO:0005096	GTPase activator activity

0.41	GO:0043234	protein complex
0.37	GO:0005886	plasma membrane
0.36	GO:0015629	actin cytoskeleton
0.35	GO:0012505	endomembrane system
0.35	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

tr|T1EGI7|T1EGI7_HELRO
Uncharacterized protein
Search

0.66	Ribosomal protein L7, eukaryotic

0.44	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.41	GO:0002181	cytoplasmic translation
0.41	GO:0035073	pupariation
0.41	GO:0000465	exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.34	GO:0051726	regulation of cell cycle
0.34	GO:0007076	mitotic chromosome condensation
0.32	GO:0006351	transcription, DNA-templated

0.38	GO:0003735	structural constituent of ribosome
0.37	GO:0003723	RNA binding
0.33	GO:0046983	protein dimerization activity

0.57	GO:0005840	ribosome
0.40	GO:0044445	cytosolic part
0.39	GO:0030687	preribosome, large subunit precursor
0.38	GO:0005730	nucleolus
0.34	GO:0000796	condensin complex

tr|T1EGI8|T1EGI8_HELRO
Uncharacterized protein
Search

PIGL

0.54	N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

0.37	GO:0006383	transcription by RNA polymerase III
0.35	GO:0006506	GPI anchor biosynthetic process
0.32	GO:0055085	transmembrane transport

0.45	GO:0000225	N-acetylglucosaminylphosphatidylinositol deacetylase activity
0.36	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.34	GO:0003677	DNA binding
0.32	GO:0022857	transmembrane transporter activity

0.37	GO:0005666	DNA-directed RNA polymerase III complex
0.34	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.45

EC:3.5.1.89

GO:0000225

tr|T1EGI9|T1EGI9_HELRO
Uncharacterized protein
Search

FAM20B

0.85	glycosaminoglycan xylosylkinase

0.51	GO:0016310	phosphorylation
0.50	GO:1903955	positive regulation of protein targeting to mitochondrion
0.44	GO:0036211	protein modification process
0.42	GO:0044267	cellular protein metabolic process
0.42	GO:0048701	embryonic cranial skeleton morphogenesis
0.42	GO:0030166	proteoglycan biosynthetic process
0.32	GO:0055085	transmembrane transport

0.53	GO:0016301	kinase activity
0.49	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.43	GO:0140096	catalytic activity, acting on a protein
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding
0.32	GO:0022857	transmembrane transporter activity

0.47	GO:0005794	Golgi apparatus
0.46	GO:0005615	extracellular space
0.45	GO:0005654	nucleoplasm
0.37	GO:0005783	endoplasmic reticulum
0.35	GO:0098588	bounding membrane of organelle
0.35	GO:0031984	organelle subcompartment
0.30	GO:0031224	intrinsic component of membrane

0.49

GO:0016773

tr|T1EGJ0|T1EGJ0_HELRO
Uncharacterized protein
Search

ALG5

0.83	Dolichyl-phosphate beta-glucosyltransferase

0.52	GO:0007368	determination of left/right symmetry
0.47	GO:0006487	protein N-linked glycosylation
0.35	GO:0007509	mesoderm migration involved in gastrulation
0.35	GO:0019991	septate junction assembly
0.35	GO:0001703	gastrulation with mouth forming first
0.34	GO:0040003	chitin-based cuticle development
0.34	GO:0018196	peptidyl-asparagine modification
0.34	GO:0009953	dorsal/ventral pattern formation
0.34	GO:0007029	endoplasmic reticulum organization
0.34	GO:0007030	Golgi organization

0.48	GO:0016740	transferase activity
0.34	GO:0046983	protein dimerization activity
0.33	GO:0140098	catalytic activity, acting on RNA
0.33	GO:0003712	transcription cofactor activity

0.44	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0000124	SAGA complex
0.30	GO:0031224	intrinsic component of membrane

0.48

GO:0016740

tr|T1EGJ1|T1EGJ1_HELRO
Uncharacterized protein
Search

0.73	Lipid phosphate phosphohydrolase

0.54	GO:0016311	dephosphorylation
0.48	GO:0006629	lipid metabolic process
0.46	GO:0035233	germ cell repulsion
0.45	GO:0007280	pole cell migration
0.45	GO:0007277	pole cell development
0.42	GO:0007281	germ cell development
0.42	GO:0030111	regulation of Wnt signaling pathway
0.41	GO:0006869	lipid transport
0.40	GO:0007602	phototransduction
0.39	GO:0019637	organophosphate metabolic process

0.61	GO:0008195	phosphatidate phosphatase activity
0.52	GO:0042577	lipid phosphatase activity
0.41	GO:0005319	lipid transporter activity
0.38	GO:0042392	sphingosine-1-phosphate phosphatase activity
0.37	GO:0005178	integrin binding

0.44	GO:0005886	plasma membrane
0.42	GO:0045177	apical part of cell
0.35	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0070062	extracellular exosome
0.33	GO:0005794	Golgi apparatus
0.30	GO:0016021	integral component of membrane

0.61

EC:3.1.3.4

GO:0008195

tr|T1EGJ2|T1EGJ2_HELRO
Uncharacterized protein
Search

0.75	glycine receptor precursor

0.61	GO:0007165	signal transduction
0.60	GO:0034220	ion transmembrane transport
0.52	GO:0060078	regulation of postsynaptic membrane potential
0.51	GO:0007268	chemical synaptic transmission
0.51	GO:0006821	chloride transport
0.43	GO:0043200	response to amino acid
0.37	GO:0045664	regulation of neuron differentiation
0.36	GO:0007417	central nervous system development
0.35	GO:0071294	cellular response to zinc ion
0.35	GO:0071361	cellular response to ethanol

0.75	GO:0005230	extracellular ligand-gated ion channel activity
0.70	GO:0004888	transmembrane signaling receptor activity
0.62	GO:0016594	glycine binding
0.56	GO:0099095	ligand-gated anion channel activity
0.55	GO:0022835	transmitter-gated channel activity
0.52	GO:0005254	chloride channel activity
0.33	GO:0004190	aspartic-type endopeptidase activity
0.33	GO:0008270	zinc ion binding
0.33	GO:0140110	transcription regulator activity

0.55	GO:0005886	plasma membrane
0.51	GO:0098794	postsynapse
0.36	GO:0043204	perikaryon
0.36	GO:0034707	chloride channel complex
0.36	GO:0030425	dendrite
0.35	GO:0030054	cell junction
0.35	GO:1902711	GABA-A receptor complex
0.32	GO:0016592	mediator complex

0.33

GO:0004190

tr|T1EGJ3|T1EGJ3_HELRO
Uncharacterized protein
Search

KCTD5

0.63	Potassium channel tetramerization domain containing 2

0.78	GO:0051260	protein homooligomerization
0.43	GO:0045187	regulation of circadian sleep/wake cycle, sleep
0.43	GO:0030431	sleep
0.43	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.34	GO:0006468	protein phosphorylation
0.33	GO:0016032	viral process

0.47	GO:0042802	identical protein binding
0.47	GO:0032403	protein complex binding
0.46	GO:0097602	cullin family protein binding
0.43	GO:0017022	myosin binding
0.39	GO:0046983	protein dimerization activity
0.34	GO:0004672	protein kinase activity
0.33	GO:0004252	serine-type endopeptidase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0031463	Cul3-RING ubiquitin ligase complex
0.42	GO:0005829	cytosol
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.33

GO:0004252

tr|T1EGJ4|T1EGJ4_HELRO
Uncharacterized protein
Search

XYLB

0.47	Xylulose kinase

0.60	GO:0005975	carbohydrate metabolic process
0.54	GO:0016310	phosphorylation
0.39	GO:0044281	small molecule metabolic process
0.34	GO:1901159	xylulose 5-phosphate biosynthetic process
0.34	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.33	GO:0044248	cellular catabolic process
0.33	GO:1901575	organic substance catabolic process
0.33	GO:0036211	protein modification process
0.33	GO:0006091	generation of precursor metabolites and energy
0.32	GO:0044267	cellular protein metabolic process

0.62	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.56	GO:0016301	kinase activity
0.35	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005057	signal transducer activity, downstream of receptor
0.33	GO:0004888	transmembrane signaling receptor activity
0.32	GO:0140096	catalytic activity, acting on a protein
0.32	GO:0016887	ATPase activity
0.32	GO:0046872	metal ion binding

0.36	GO:0070062	extracellular exosome
0.35	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.62

GO:0016773

tr|T1EGJ5|T1EGJ5_HELRO
Uncharacterized protein
Search

0.66	GO:0010466	negative regulation of peptidase activity
0.64	GO:0052548	regulation of endopeptidase activity
0.39	GO:1903506	regulation of nucleic acid-templated transcription
0.39	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.39	GO:0010468	regulation of gene expression
0.37	GO:0055016	hypochord development
0.36	GO:0014028	notochord formation
0.36	GO:0007634	optokinetic behavior
0.36	GO:0034633	retinol transport
0.36	GO:0003140	determination of left/right asymmetry in lateral mesoderm

0.67	GO:0030414	peptidase inhibitor activity
0.65	GO:0061135	endopeptidase regulator activity
0.55	GO:0005509	calcium ion binding
0.41	GO:0008270	zinc ion binding
0.41	GO:0003700	DNA binding transcription factor activity
0.36	GO:0034632	retinol transmembrane transporter activity
0.36	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.36	GO:0005501	retinoid binding
0.35	GO:0005201	extracellular matrix structural constituent
0.35	GO:0005044	scavenger receptor activity

0.46	GO:0005576	extracellular region
0.41	GO:0005634	nucleus
0.35	GO:0030687	preribosome, large subunit precursor
0.34	GO:0043233	organelle lumen
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.36

GO:0004715

tr|T1EGJ6|T1EGJ6_HELRO
Uncharacterized protein
Search

LAP3

0.69	Cytosol aminopeptidase

0.61	GO:0006508	proteolysis
0.32	GO:0006898	receptor-mediated endocytosis

0.74	GO:0008235	metalloexopeptidase activity
0.73	GO:0030145	manganese ion binding
0.71	GO:0004177	aminopeptidase activity
0.33	GO:0008410	CoA-transferase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0005044	scavenger receptor activity

0.49	GO:0005737	cytoplasm
0.42	GO:0030496	midbody
0.39	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.71

EC:3.4.11

GO:0004177

tr|T1EGJ7|T1EGJ7_HELRO
Uncharacterized protein
Search

TRIM67

0.82	Tripartite motif containing 9

0.51	GO:0035544	negative regulation of SNARE complex assembly
0.45	GO:0016567	protein ubiquitination
0.44	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.43	GO:0010975	regulation of neuron projection development
0.43	GO:0046580	negative regulation of Ras protein signal transduction
0.42	GO:0031346	positive regulation of cell projection organization
0.42	GO:0045666	positive regulation of neuron differentiation
0.37	GO:0048936	peripheral nervous system neuron axonogenesis
0.37	GO:0090325	regulation of locomotion involved in locomotory behavior
0.37	GO:0016199	axon midline choice point recognition

0.58	GO:0008270	zinc ion binding
0.45	GO:0004842	ubiquitin-protein transferase activity
0.44	GO:0016874	ligase activity
0.36	GO:0019904	protein domain specific binding
0.36	GO:0042803	protein homodimerization activity
0.32	GO:0000149	SNARE binding

0.44	GO:0005622	intracellular
0.38	GO:0043005	neuron projection
0.38	GO:0120038	plasma membrane bounded cell projection part
0.37	GO:0036477	somatodendritic compartment
0.36	GO:0030427	site of polarized growth
0.34	GO:0044297	cell body
0.33	GO:0098793	presynapse
0.33	GO:0030054	cell junction
0.33	GO:0031982	vesicle
0.32	GO:0012505	endomembrane system

0.44	EC:6	GO:0016874
0.45	KEGG:R03876	GO:0004842

tr|T1EGJ8|T1EGJ8_HELRO
Uncharacterized protein
Search

0.49	Phosphatidylinositol 4-kinase alpha

0.79	GO:0048015	phosphatidylinositol-mediated signaling
0.73	GO:0046854	phosphatidylinositol phosphorylation
0.46	GO:0046786	viral replication complex formation and maintenance
0.42	GO:0035118	embryonic pectoral fin morphogenesis
0.42	GO:0030036	actin cytoskeleton organization
0.40	GO:0039694	viral RNA genome replication
0.40	GO:0044803	multi-organism membrane organization
0.34	GO:0006661	phosphatidylinositol biosynthetic process

0.59	GO:0016301	kinase activity
0.43	GO:0045296	cadherin binding
0.39	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.46	GO:0019034	viral replication complex
0.44	GO:0005622	intracellular
0.38	GO:0005886	plasma membrane
0.35	GO:0031982	vesicle
0.35	GO:0098805	whole membrane
0.35	GO:0098588	bounding membrane of organelle
0.34	GO:0005925	focal adhesion
0.34	GO:0043230	extracellular organelle
0.34	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane

0.39

GO:0016773

tr|T1EGJ9|T1EGJ9_HELRO
40S ribosomal protein S26
Search

RPS26

0.67	40S ribosomal protein S26

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.41	GO:0033119	negative regulation of RNA splicing
0.34	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.34	GO:0019083	viral transcription
0.33	GO:0016072	rRNA metabolic process
0.33	GO:0042254	ribosome biogenesis

0.64	GO:0003735	structural constituent of ribosome
0.45	GO:0003729	mRNA binding
0.40	GO:0045296	cadherin binding

0.61	GO:0005840	ribosome
0.46	GO:0044445	cytosolic part
0.43	GO:0005844	polysome
0.43	GO:0098556	cytoplasmic side of rough endoplasmic reticulum membrane
0.36	GO:0070062	extracellular exosome
0.33	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

tr|T1EGK0|T1EGK0_HELRO
Uncharacterized protein
Search

0.85

GO:1901031

regulation of response to reactive oxygen species

0.61	GO:0005634	nucleus
0.30	GO:0044425	membrane part

tr|T1EGK1|T1EGK1_HELRO
Uncharacterized protein
Search

XPR1

0.74	xenotropic and polytropic retrovirus receptor 1 homolog

0.50	GO:0072502	cellular trivalent inorganic anion homeostasis
0.50	GO:0072501	cellular divalent inorganic anion homeostasis
0.50	GO:0030320	cellular monovalent inorganic anion homeostasis
0.50	GO:0055062	phosphate ion homeostasis
0.49	GO:0035435	phosphate ion transmembrane transport
0.47	GO:0009615	response to virus
0.45	GO:0051806	entry into cell of other organism involved in symbiotic interaction
0.45	GO:0044409	entry into host
0.43	GO:0019058	viral life cycle
0.41	GO:0008039	synaptic target recognition

0.54	GO:0000822	inositol hexakisphosphate binding
0.53	GO:0104005	hijacked molecular function
0.50	GO:0015114	phosphate ion transmembrane transporter activity
0.48	GO:0015562	efflux transmembrane transporter activity
0.43	GO:0004872	receptor activity
0.33	GO:0004335	galactokinase activity
0.33	GO:0005534	galactose binding
0.33	GO:0004871	signal transducer activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0031226	intrinsic component of plasma membrane
0.35	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.33	EC:2.7.1.6	GO:0004335
0.33	KEGG:R01092	GO:0004335

tr|T1EGK2|T1EGK2_HELRO
Uncharacterized protein
Search

0.82	GO:0007016	cytoskeletal anchoring at plasma membrane
0.80	GO:0030866	cortical actin cytoskeleton organization
0.77	GO:0001558	regulation of cell growth
0.54	GO:0002175	protein localization to paranode region of axon
0.54	GO:0030913	paranodal junction assembly
0.53	GO:0071205	protein localization to juxtaparanode region of axon
0.53	GO:0043217	myelin maintenance
0.51	GO:0072659	protein localization to plasma membrane
0.49	GO:0048812	neuron projection morphogenesis
0.45	GO:0008360	regulation of cell shape

0.70	GO:0008092	cytoskeletal protein binding
0.59	GO:0005198	structural molecule activity

0.74	GO:0005911	cell-cell junction
0.69	GO:0005856	cytoskeleton
0.54	GO:0005886	plasma membrane
0.54	GO:0044224	juxtaparanode region of axon
0.53	GO:0033270	paranode region of axon
0.51	GO:0014069	postsynaptic density
0.50	GO:0031252	cell leading edge
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1EGK3|T1EGK3_HELRO
Uncharacterized protein
Search

0.68	Neurofibromin truncated

0.75	GO:0043087	regulation of GTPase activity
0.61	GO:0007165	signal transduction
0.53	GO:0045762	positive regulation of adenylate cyclase activity
0.52	GO:0008306	associative learning
0.51	GO:0042063	gliogenesis
0.50	GO:0051961	negative regulation of nervous system development
0.49	GO:1904397	negative regulation of neuromuscular junction development
0.49	GO:0007614	short-term memory
0.49	GO:0046578	regulation of Ras protein signal transduction
0.49	GO:0051345	positive regulation of hydrolase activity

0.49	GO:0005096	GTPase activator activity
0.45	GO:0031210	phosphatidylcholine binding
0.44	GO:0008429	phosphatidylethanolamine binding
0.33	GO:0005515	protein binding
0.31	GO:0097367	carbohydrate derivative binding

0.43	GO:0030425	dendrite
0.43	GO:0030424	axon
0.41	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane
0.41	GO:0098793	presynapse
0.36	GO:0005622	intracellular
0.33	GO:0043233	organelle lumen
0.32	GO:0043228	non-membrane-bounded organelle
0.32	GO:0043227	membrane-bounded organelle
0.31	GO:0014069	postsynaptic density
0.31	GO:0043234	protein complex

tr|T1EGK4|T1EGK4_HELRO
Uncharacterized protein
Search

0.61	Potassium voltage-gated channel subfamily H member 7

0.73	GO:0071805	potassium ion transmembrane transport
0.73	GO:0034765	regulation of ion transmembrane transport
0.42	GO:0042391	regulation of membrane potential
0.38	GO:0044057	regulation of system process
0.37	GO:0046662	regulation of oviposition
0.36	GO:0007617	mating behavior
0.36	GO:0035637	multicellular organismal signaling
0.34	GO:0023014	signal transduction by protein phosphorylation
0.34	GO:0000160	phosphorelay signal transduction system

0.78	GO:0005249	voltage-gated potassium channel activity
0.34	GO:0000155	phosphorelay sensor kinase activity

0.39	GO:0005887	integral component of plasma membrane
0.32	GO:0005622	intracellular

0.34

GO:0000155

tr|T1EGK5|T1EGK5_HELRO
Uncharacterized protein
Search

0.34

GO:0035335

peptidyl-tyrosine dephosphorylation

0.74	GO:0008017	microtubule binding
0.69	GO:0005509	calcium ion binding
0.57	GO:0003779	actin binding
0.39	GO:0002162	dystroglycan binding
0.36	GO:0008093	cytoskeletal adaptor activity
0.34	GO:0004725	protein tyrosine phosphatase activity

0.54	GO:0005856	cytoskeleton
0.30	GO:0044425	membrane part

0.34

GO:0004725

tr|T1EGK6|T1EGK6_HELRO
Uncharacterized protein
Search

0.53	GO:0055114	oxidation-reduction process
0.39	GO:0017085	response to insecticide
0.37	GO:0006710	androgen catabolic process
0.37	GO:2000866	positive regulation of estradiol secretion
0.37	GO:0002677	negative regulation of chronic inflammatory response
0.37	GO:0010760	negative regulation of macrophage chemotaxis
0.37	GO:0061370	testosterone biosynthetic process
0.37	GO:0060736	prostate gland growth
0.37	GO:0030540	female genitalia development
0.37	GO:0060065	uterus development

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.65	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.36	GO:0030342	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
0.34	GO:0010181	FMN binding
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.33	GO:0035299	inositol pentakisphosphate 2-kinase activity

0.35	GO:0031966	mitochondrial membrane
0.35	GO:0005783	endoplasmic reticulum
0.33	GO:0019866	organelle inner membrane
0.32	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.32	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.68	EC:1.14	GO:0016705
0.33	KEGG:R05202	GO:0035299

tr|T1EGK7|T1EGK7_HELRO
Guanylate cyclase
Search

0.46	Guanylate cyclase

0.81	GO:0006182	cGMP biosynthetic process
0.62	GO:0006468	protein phosphorylation
0.62	GO:0035556	intracellular signal transduction
0.38	GO:0007020	microtubule nucleation
0.36	GO:0050908	detection of light stimulus involved in visual perception
0.35	GO:0018212	peptidyl-tyrosine modification
0.34	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0055114	oxidation-reduction process

0.82	GO:0004383	guanylate cyclase activity
0.63	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0004016	adenylate cyclase activity
0.38	GO:0043015	gamma-tubulin binding
0.35	GO:0051287	NAD binding
0.35	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
0.34	GO:0032550	purine ribonucleoside binding

0.45	GO:0005622	intracellular
0.37	GO:0009897	external side of plasma membrane
0.36	GO:0043234	protein complex
0.35	GO:0043228	non-membrane-bounded organelle
0.34	GO:0044422	organelle part
0.30	GO:0016021	integral component of membrane

0.82

EC:4.6.1.2

GO:0004383

tr|T1EGK8|T1EGK8_HELRO
Uncharacterized protein
Search

FANCM

0.45	Fanconi anemia group M protein homolog

0.59	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.56	GO:0000712	resolution of meiotic recombination intermediates
0.55	GO:0031297	replication fork processing
0.36	GO:0006281	DNA repair

0.60	GO:0004518	nuclease activity
0.53	GO:0003677	DNA binding
0.52	GO:0032559	adenyl ribonucleotide binding
0.51	GO:0003682	chromatin binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0004386	helicase activity
0.33	GO:0005515	protein binding
0.33	GO:0140097	catalytic activity, acting on DNA

0.56	GO:0071821	FANCM-MHF complex
0.55	GO:0043240	Fanconi anaemia nuclear complex

0.60

GO:0004518

tr|T1EGK9|T1EGK9_HELRO
Uncharacterized protein
Search

0.52	GO:0051301	cell division
0.52	GO:0007049	cell cycle
0.51	GO:0006260	DNA replication

0.45

GO:0003677

DNA binding

0.61	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

tr|T1EGL0|T1EGL0_HELRO
Uncharacterized protein
Search

ACBD3

0.90	Acyl-Coenzyme A binding domain containing 3

0.34	GO:0006694	steroid biosynthetic process
0.32	GO:0097659	nucleic acid-templated transcription
0.32	GO:0010467	gene expression
0.32	GO:0034645	cellular macromolecule biosynthetic process

0.78	GO:0000062	fatty-acyl-CoA binding
0.51	GO:0034237	protein kinase A regulatory subunit binding

0.46	GO:0000139	Golgi membrane
0.33	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

tr|T1EGL1|T1EGL1_HELRO
Uncharacterized protein
Search

0.32	Phospholipase A2 group VI

0.72	GO:0016042	lipid catabolic process
0.42	GO:0070328	triglyceride homeostasis
0.42	GO:1902884	positive regulation of response to oxidative stress
0.41	GO:0019731	antibacterial humoral response
0.39	GO:0032049	cardiolipin biosynthetic process

0.51	GO:0016787	hydrolase activity
0.36	GO:0019904	protein domain specific binding

0.39	GO:0005815	microtubule organizing center
0.38	GO:0005615	extracellular space
0.37	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.51

GO:0016787

tr|T1EGL2|T1EGL2_HELRO
Uncharacterized protein
Search

tr|T1EGL3|T1EGL3_HELRO
Uncharacterized protein
Search

0.62	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.43	GO:0007018	microtubule-based movement
0.42	GO:0071897	DNA biosynthetic process
0.42	GO:0006260	DNA replication
0.41	GO:0006364	rRNA processing
0.36	GO:0016310	phosphorylation
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:0010468	regulation of gene expression
0.35	GO:0022616	DNA strand elongation

0.57	GO:0005509	calcium ion binding
0.44	GO:0005515	protein binding
0.44	GO:0003777	microtubule motor activity
0.43	GO:0003887	DNA-directed DNA polymerase activity
0.39	GO:0032559	adenyl ribonucleotide binding
0.39	GO:0008144	drug binding
0.39	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0003677	DNA binding
0.37	GO:0016301	kinase activity
0.37	GO:0004075	biotin carboxylase activity

0.47	GO:0005886	plasma membrane
0.43	GO:0032040	small-subunit processome
0.41	GO:0005634	nucleus
0.36	GO:0009343	biotin carboxylase complex
0.35	GO:0043233	organelle lumen
0.35	GO:0044446	intracellular organelle part
0.35	GO:0043232	intracellular non-membrane-bounded organelle
0.35	GO:0020011	apicoplast
0.34	GO:0042575	DNA polymerase complex
0.34	GO:0030137	COPI-coated vesicle

0.43

GO:0003887

tr|T1EGL4|T1EGL4_HELRO
Uncharacterized protein
Search

0.10	Transmembrane protein 57 (Fragment)

0.58	GO:0023041	neuronal signal transduction
0.50	GO:0007420	brain development

0.54	GO:0030867	rough endoplasmic reticulum membrane
0.53	GO:0044306	neuron projection terminus
0.52	GO:0031965	nuclear membrane
0.51	GO:0030424	axon
0.49	GO:0045202	synapse
0.30	GO:0031224	intrinsic component of membrane

tr|T1EGL5|T1EGL5_HELRO
Uncharacterized protein
Search

0.73	Putative rna-binding protein sam68

0.65	GO:0006417	regulation of translation
0.38	GO:2000196	positive regulation of female gonad development
0.38	GO:0001709	cell fate determination
0.38	GO:2000623	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.38	GO:1905936	regulation of germ cell proliferation
0.38	GO:0060282	positive regulation of oocyte development
0.36	GO:0034249	negative regulation of cellular amide metabolic process
0.36	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.35	GO:0032269	negative regulation of cellular protein metabolic process
0.35	GO:2000113	negative regulation of cellular macromolecule biosynthetic process

0.72	GO:0003727	single-stranded RNA binding
0.38	GO:0003730	mRNA 3'-UTR binding
0.38	GO:0046872	metal ion binding
0.37	GO:0048027	mRNA 5'-UTR binding
0.35	GO:0097157	pre-mRNA intronic binding
0.34	GO:0005515	protein binding

0.38	GO:0043186	P granule
0.35	GO:0005829	cytosol
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EGL6|T1EGL6_HELRO
Uncharacterized protein
Search

0.53	GO:2001141	regulation of RNA biosynthetic process
0.53	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:0010468	regulation of gene expression
0.42	GO:0048513	animal organ development
0.41	GO:0035476	angioblast cell migration
0.41	GO:0072554	blood vessel lumenization
0.41	GO:1904888	cranial skeletal system development
0.41	GO:0035907	dorsal aorta development
0.41	GO:0007368	determination of left/right symmetry
0.41	GO:0060841	venous blood vessel development

0.52	GO:0003677	DNA binding
0.37	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.36	GO:0003682	chromatin binding
0.33	GO:0016630	protochlorophyllide reductase activity
0.33	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
0.32	GO:0022857	transmembrane transporter activity

0.57	GO:0005634	nucleus
0.37	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.33

EC:1.3.1.33

GO:0016630

tr|T1EGL7|T1EGL7_HELRO
Uncharacterized protein
Search

0.30

GO:0044425

membrane part

tr|T1EGL8|T1EGL8_HELRO
Uncharacterized protein
Search

0.54	GO:0055085	transmembrane transport
0.40	GO:0006879	cellular iron ion homeostasis
0.36	GO:0010380	regulation of chlorophyll biosynthetic process
0.36	GO:0010288	response to lead ion
0.36	GO:0015691	cadmium ion transport
0.36	GO:0009555	pollen development
0.36	GO:0009658	chloroplast organization
0.36	GO:0046686	response to cadmium ion
0.36	GO:0048364	root development
0.35	GO:0006777	Mo-molybdopterin cofactor biosynthetic process

0.64	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0015434	cadmium-transporting ATPase activity
0.34	GO:0003729	mRNA binding
0.34	GO:0008488	gamma-glutamyl carboxylase activity
0.34	GO:0042910	xenobiotic transmembrane transporter activity
0.33	GO:0015238	drug transmembrane transporter activity
0.33	GO:0005509	calcium ion binding

0.37	GO:0031967	organelle envelope
0.37	GO:0005739	mitochondrion
0.37	GO:0031090	organelle membrane
0.34	GO:0044434	chloroplast part
0.34	GO:0016607	nuclear speck
0.32	GO:0019028	viral capsid
0.30	GO:0031224	intrinsic component of membrane

0.37

EC:3.6.3.46

GO:0015434

tr|T1EGL9|T1EGL9_HELRO
Uncharacterized protein
Search

0.44	Glutamine synthetase 2 cytoplasmic (inferred by orthology to a D. melanogaster protein)

0.75	GO:0006542	glutamine biosynthetic process
0.42	GO:0019676	ammonia assimilation cycle
0.34	GO:0007064	mitotic sister chromatid cohesion
0.33	GO:0006468	protein phosphorylation

0.76	GO:0004356	glutamate-ammonia ligase activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0003723	RNA binding

0.39	GO:0034399	nuclear periphery
0.34	GO:0031390	Ctf18 RFC-like complex
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.76	EC:6.3.1.2	GO:0004356
0.76	KEGG:R00253	GO:0004356

tr|T1EGM0|T1EGM0_HELRO
Uncharacterized protein
Search

0.54	Ribosomal protein L19e

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process

0.64

GO:0003735

structural constituent of ribosome

0.61	GO:0005840	ribosome
0.55	GO:0044445	cytosolic part
0.47	GO:0044446	intracellular organelle part

tr|T1EGM1|T1EGM1_HELRO
Uncharacterized protein
Search

0.61	Putative Ammonium transporter Rh type C (Fragment)

0.77	GO:0072488	ammonium transmembrane transport
0.50	GO:0015670	carbon dioxide transport
0.48	GO:0006873	cellular ion homeostasis
0.48	GO:0060586	multicellular organismal iron ion homeostasis
0.46	GO:0048821	erythrocyte development
0.45	GO:0015695	organic cation transport
0.44	GO:0070634	transepithelial ammonium transport
0.41	GO:0015672	monovalent inorganic cation transport
0.40	GO:0006885	regulation of pH
0.32	GO:0006468	protein phosphorylation

0.77	GO:0008519	ammonium transmembrane transporter activity
0.53	GO:0030506	ankyrin binding
0.50	GO:0022842	narrow pore channel activity
0.39	GO:0042802	identical protein binding
0.33	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.33	GO:0004672	protein kinase activity
0.32	GO:0020037	heme binding
0.32	GO:0005506	iron ion binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding

0.43	GO:0005887	integral component of plasma membrane
0.41	GO:0016323	basolateral plasma membrane
0.41	GO:0016324	apical plasma membrane
0.36	GO:0031410	cytoplasmic vesicle
0.34	GO:0005576	extracellular region
0.34	GO:0014731	spectrin-associated cytoskeleton
0.34	GO:0045178	basal part of cell
0.34	GO:0046658	anchored component of plasma membrane

0.33

GO:0016705

tr|T1EGM2|T1EGM2_HELRO
Sodium channel protein
Search

0.61	Voltage gated sodium channel (Fragment)

0.76	GO:0034765	regulation of ion transmembrane transport
0.76	GO:0035725	sodium ion transmembrane transport
0.46	GO:0019233	sensory perception of pain
0.36	GO:0019228	neuronal action potential
0.36	GO:0086010	membrane depolarization during action potential
0.35	GO:0086043	bundle of His cell action potential
0.35	GO:0086016	AV node cell action potential
0.35	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
0.34	GO:0055117	regulation of cardiac muscle contraction
0.34	GO:0002027	regulation of heart rate

0.83	GO:0005248	voltage-gated sodium channel activity
0.74	GO:0022832	voltage-gated channel activity
0.71	GO:0022839	ion gated channel activity
0.71	GO:0008381	mechanosensitive ion channel activity
0.65	GO:0005509	calcium ion binding
0.34	GO:0044325	ion channel binding
0.33	GO:0008081	phosphoric diester hydrolase activity
0.33	GO:0005267	potassium channel activity

0.82	GO:0001518	voltage-gated sodium channel complex
0.33	GO:0008076	voltage-gated potassium channel complex

0.33

GO:0008081

tr|T1EGM3|T1EGM3_HELRO
Uncharacterized protein
Search

SLO-1

0.75	Calcium-activated BK potassium channel alpha subunit

0.73	GO:0071805	potassium ion transmembrane transport
0.44	GO:0043050	pharyngeal pumping
0.43	GO:0048149	behavioral response to ethanol
0.42	GO:0046928	regulation of neurotransmitter secretion
0.42	GO:0045214	sarcomere organization
0.38	GO:0040011	locomotion

0.85	GO:0060072	large conductance calcium-activated potassium channel activity
0.76	GO:0005249	voltage-gated potassium channel activity
0.36	GO:0005515	protein binding
0.32	GO:0046872	metal ion binding

0.76	GO:0008076	voltage-gated potassium channel complex
0.43	GO:0055120	striated muscle dense body
0.42	GO:0031430	M band
0.40	GO:0045202	synapse

tr|T1EGM4|T1EGM4_HELRO
Uncharacterized protein
Search

CAC

0.45	Voltage-dependent L-type calcium channel subunit alpha

0.77	GO:0070588	calcium ion transmembrane transport
0.77	GO:0034765	regulation of ion transmembrane transport
0.40	GO:0035545	determination of left/right asymmetry in nervous system
0.40	GO:0007626	locomotory behavior
0.39	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.38	GO:0042594	response to starvation
0.38	GO:0086010	membrane depolarization during action potential
0.38	GO:0001505	regulation of neurotransmitter levels
0.38	GO:0009628	response to abiotic stimulus
0.35	GO:0016057	regulation of membrane potential in photoreceptor cell

0.82	GO:0005245	voltage-gated calcium channel activity
0.68	GO:0005509	calcium ion binding

0.81	GO:0005891	voltage-gated calcium channel complex
0.41	GO:0048787	presynaptic active zone membrane
0.34	GO:0031594	neuromuscular junction
0.34	GO:0016323	basolateral plasma membrane
0.34	GO:0016324	apical plasma membrane
0.32	GO:0005622	intracellular

tr|T1EGM5|T1EGM5_HELRO
Uncharacterized protein
Search

EPHA3

0.53	Receptor protein-tyrosine kinase

0.78	GO:0048013	ephrin receptor signaling pathway
0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.51	GO:0071300	cellular response to retinoic acid
0.51	GO:0045806	negative regulation of endocytosis
0.51	GO:0051893	regulation of focal adhesion assembly
0.51	GO:1903078	positive regulation of protein localization to plasma membrane
0.51	GO:0007399	nervous system development
0.49	GO:0031346	positive regulation of cell projection organization
0.49	GO:0010720	positive regulation of cell development
0.49	GO:0051962	positive regulation of nervous system development

0.80	GO:0005003	ephrin receptor activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0004568	chitinase activity
0.34	GO:0005515	protein binding

0.60	GO:0005887	integral component of plasma membrane
0.49	GO:0005769	early endosome
0.34	GO:0005576	extracellular region
0.34	GO:0005912	adherens junction

0.34

EC:3.2.1.14

GO:0004568

tr|T1EGM6|T1EGM6_HELRO
Receptor protein-tyrosine kinase
Search

0.65	Receptor protein-tyrosine kinase

0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.75	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.56	GO:0023014	signal transduction by protein phosphorylation
0.53	GO:0035556	intracellular signal transduction
0.33	GO:0046777	protein autophosphorylation
0.32	GO:0045087	innate immune response
0.32	GO:0016477	cell migration
0.32	GO:0042127	regulation of cell proliferation
0.32	GO:0030154	cell differentiation

0.78	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.71	GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.32	GO:0005102	receptor binding

0.41	GO:0005622	intracellular
0.32	GO:0019897	extrinsic component of plasma membrane
0.32	GO:0009898	cytoplasmic side of plasma membrane
0.30	GO:0016021	integral component of membrane

0.78

EC:2.7.10.1

GO:0004714

tr|T1EGM7|T1EGM7_HELRO
Uncharacterized protein
Search

GATB

0.70	Glutamyl-tRNA amidotransferase subunit B

0.76	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation
0.72	GO:0032543	mitochondrial translation
0.34	GO:0006425	glutaminyl-tRNA aminoacylation
0.33	GO:0006414	translational elongation

0.71	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor
0.59	GO:0140101	catalytic activity, acting on a tRNA
0.50	GO:0032559	adenyl ribonucleotide binding
0.49	GO:0008144	drug binding
0.49	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0016740	transferase activity
0.34	GO:0008135	translation factor activity, RNA binding

0.70	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex
0.55	GO:0005739	mitochondrion
0.34	GO:0005853	eukaryotic translation elongation factor 1 complex
0.30	GO:0016020	membrane

0.71

EC:6.3.5

GO:0016884

tr|T1EGM8|T1EGM8_HELRO
Uncharacterized protein
Search

0.78	Calcium-activated potassium channel

0.73	GO:0071805	potassium ion transmembrane transport
0.41	GO:0022900	electron transport chain
0.35	GO:0016057	regulation of membrane potential in photoreceptor cell
0.33	GO:0007165	signal transduction

0.85	GO:0016286	small conductance calcium-activated potassium channel activity
0.79	GO:0005516	calmodulin binding
0.41	GO:0020037	heme binding
0.41	GO:0009055	electron transfer activity
0.38	GO:0046872	metal ion binding
0.34	GO:0009881	photoreceptor activity

0.36	GO:0043025	neuronal cell body
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1EGM9|T1EGM9_HELRO
Uncharacterized protein
Search

SHKBP1

0.67	SH3KBP1-binding protein 1

0.78	GO:0051260	protein homooligomerization
0.65	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway

0.42

GO:0005515

protein binding

0.56

GO:0005764

lysosome

tr|T1EGN0|T1EGN0_HELRO
Sodium/hydrogen exchanger
Search

SLC9A7

0.57	Sodium/hydrogen exchanger

0.78	GO:0006885	regulation of pH
0.76	GO:0035725	sodium ion transmembrane transport
0.62	GO:1902600	hydrogen ion transmembrane transport
0.47	GO:0099587	inorganic ion import across plasma membrane
0.46	GO:0030004	cellular monovalent inorganic cation homeostasis
0.43	GO:0071805	potassium ion transmembrane transport
0.42	GO:0035335	peptidyl-tyrosine dephosphorylation
0.41	GO:0015689	molybdate ion transport
0.38	GO:0097484	dendrite extension
0.38	GO:0048675	axon extension

0.81	GO:0015385	sodium:proton antiporter activity
0.47	GO:0015386	potassium:proton antiporter activity
0.43	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.42	GO:0015098	molybdate ion transmembrane transporter activity
0.42	GO:0004725	protein tyrosine phosphatase activity
0.33	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.49	GO:0055037	recycling endosome
0.39	GO:0010008	endosome membrane
0.38	GO:0005886	plasma membrane
0.38	GO:0043231	intracellular membrane-bounded organelle
0.38	GO:0005770	late endosome
0.37	GO:0044308	axonal spine
0.37	GO:0005769	early endosome
0.37	GO:0043679	axon terminus
0.36	GO:0030425	dendrite
0.36	GO:0031984	organelle subcompartment

0.43

EC:3.1.3

GO:0008138

tr|T1EGN1|T1EGN1_HELRO
Uncharacterized protein
Search

VARS2

0.43	Valyl-tRNA synthetase/valine-tRNA ligase

0.77	GO:0006438	valyl-tRNA aminoacylation
0.73	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity
0.36	GO:0006289	nucleotide-excision repair
0.35	GO:0032392	DNA geometric change

0.77	GO:0004832	valine-tRNA ligase activity
0.73	GO:0002161	aminoacyl-tRNA editing activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0004003	ATP-dependent DNA helicase activity
0.34	GO:0030246	carbohydrate binding
0.33	GO:0005515	protein binding
0.32	GO:0016757	transferase activity, transferring glycosyl groups

0.42	GO:0005829	cytosol
0.41	GO:0005739	mitochondrion
0.37	GO:0000439	core TFIIH complex

0.77	EC:6.1.1.9	GO:0004832
0.77	KEGG:R03665	GO:0004832

tr|T1EGN2|T1EGN2_HELRO
Uncharacterized protein
Search

0.72	Neuropeptide Y receptor

0.76	GO:0007218	neuropeptide signaling pathway
0.50	GO:2000252	negative regulation of feeding behavior
0.47	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.45	GO:0009755	hormone-mediated signaling pathway
0.36	GO:0007217	tachykinin receptor signaling pathway
0.35	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway
0.35	GO:0086100	endothelin receptor signaling pathway
0.34	GO:0048484	enteric nervous system development
0.34	GO:0006468	protein phosphorylation
0.34	GO:0042310	vasoconstriction

0.79	GO:0004983	neuropeptide Y receptor activity
0.51	GO:0042071	leucokinin receptor activity
0.37	GO:0050254	rhodopsin kinase activity
0.36	GO:0004995	tachykinin receptor activity
0.35	GO:0004935	adrenergic receptor activity
0.35	GO:0004962	endothelin receptor activity
0.33	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.33	GO:0005549	odorant binding
0.33	GO:0004984	olfactory receptor activity
0.32	GO:0004386	helicase activity

0.47	GO:0016323	basolateral plasma membrane
0.33	GO:0005887	integral component of plasma membrane
0.32	GO:0005622	intracellular

0.37

EC:2.7.11.14

GO:0050254

tr|T1EGN3|T1EGN3_HELRO
Uncharacterized protein
Search

0.70	Nucleolysin TIA-1 isoform p40 like protein (Fragment)

0.45	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.32	GO:0055114	oxidation-reduction process

0.59	GO:0003723	RNA binding
0.32	GO:0016491	oxidoreductase activity
0.32	GO:0003677	DNA binding

0.35	GO:0019013	viral nucleocapsid
0.34	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0044425	membrane part

0.32

GO:0016491

tr|T1EGN4|T1EGN4_HELRO
Uncharacterized protein
Search

GAA

0.46	Lysosomal alpha-glucosidase

0.60	GO:0005975	carbohydrate metabolic process
0.56	GO:0043181	vacuolar sequestering
0.55	GO:0002086	diaphragm contraction
0.53	GO:0050884	neuromuscular process controlling posture
0.53	GO:0002026	regulation of the force of heart contraction
0.52	GO:0046716	muscle cell cellular homeostasis
0.52	GO:0060048	cardiac muscle contraction
0.52	GO:0050885	neuromuscular process controlling balance
0.51	GO:0007040	lysosome organization
0.50	GO:0003007	heart morphogenesis

0.69	GO:0030246	carbohydrate binding
0.66	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.35	GO:0051539	4 iron, 4 sulfur cluster binding
0.34	GO:0046872	metal ion binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003677	DNA binding

0.50	GO:0005764	lysosome
0.38	GO:0098852	lytic vacuole membrane
0.36	GO:0070062	extracellular exosome
0.35	GO:0101003	ficolin-1-rich granule membrane
0.35	GO:0070821	tertiary granule membrane
0.35	GO:0005775	vacuolar lumen
0.33	GO:0005634	nucleus
0.32	GO:0005886	plasma membrane
0.32	GO:0045177	apical part of cell
0.30	GO:0016021	integral component of membrane

0.66

GO:0004553

tr|T1EGN5|T1EGN5_HELRO
Uncharacterized protein
Search

PTPN2

0.62	Tyrosine-protein phosphatase non-receptor type

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.56	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway
0.55	GO:1903897	regulation of PERK-mediated unfolded protein response
0.53	GO:1902235	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.53	GO:0061097	regulation of protein tyrosine kinase activity
0.53	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway
0.53	GO:2000646	positive regulation of receptor catabolic process
0.52	GO:0008286	insulin receptor signaling pathway
0.52	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.52	GO:1900102	negative regulation of endoplasmic reticulum unfolded protein response

0.75	GO:0004725	protein tyrosine phosphatase activity
0.53	GO:0030971	receptor tyrosine kinase binding
0.50	GO:0050839	cell adhesion molecule binding
0.50	GO:0046875	ephrin receptor binding
0.42	GO:0008270	zinc ion binding
0.41	GO:0097677	STAT family protein binding
0.41	GO:0032403	protein complex binding
0.40	GO:0019905	syntaxin binding
0.39	GO:0051721	protein phosphatase 2A binding
0.33	GO:0003723	RNA binding

0.52	GO:0097443	sorting endosome
0.51	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane
0.49	GO:0005769	early endosome
0.41	GO:0005886	plasma membrane
0.40	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.40	GO:0005829	cytosol
0.39	GO:0005654	nucleoplasm
0.36	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0031967	organelle envelope
0.34	GO:0044429	mitochondrial part

0.75

GO:0004725

tr|T1EGN6|T1EGN6_HELRO
Uncharacterized protein
Search

AKT3

0.40	Rac serine threonine-protein kinase

0.63	GO:0006468	protein phosphorylation
0.47	GO:1905653	positive regulation of artery morphogenesis
0.46	GO:0045793	positive regulation of cell size
0.46	GO:1905564	positive regulation of vascular endothelial cell proliferation
0.46	GO:0048873	homeostasis of number of cells within a tissue
0.46	GO:2000773	negative regulation of cellular senescence
0.46	GO:0048854	brain morphogenesis
0.46	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis
0.45	GO:0000002	mitochondrial genome maintenance
0.44	GO:0032008	positive regulation of TOR signaling

0.70	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0015035	protein disulfide oxidoreductase activity
0.35	GO:0005080	protein kinase C binding
0.35	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.35	GO:0009055	electron transfer activity
0.35	GO:0005516	calmodulin binding

0.36	GO:0120038	plasma membrane bounded cell projection part
0.35	GO:0031256	leading edge membrane
0.35	GO:0001726	ruffle
0.35	GO:0005829	cytosol
0.35	GO:0043025	neuronal cell body
0.35	GO:0097447	dendritic tree
0.35	GO:0098590	plasma membrane region
0.35	GO:0030424	axon
0.35	GO:0005938	cell cortex
0.34	GO:0005634	nucleus

0.70

GO:0004674

tr|T1EGN7|T1EGN7_HELRO
Uncharacterized protein
Search

0.91	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily H member 5

0.75	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.65	GO:0023014	signal transduction by protein phosphorylation
0.62	GO:0000160	phosphorelay signal transduction system
0.48	GO:0071277	cellular response to calcium ion
0.47	GO:0048015	phosphatidylinositol-mediated signaling
0.46	GO:0021576	hindbrain formation
0.45	GO:0042127	regulation of cell proliferation
0.45	GO:0042391	regulation of membrane potential
0.44	GO:0001756	somitogenesis

0.78	GO:0005249	voltage-gated potassium channel activity
0.65	GO:0000155	phosphorelay sensor kinase activity
0.47	GO:1902936	phosphatidylinositol bisphosphate binding
0.39	GO:0005516	calmodulin binding
0.38	GO:0044325	ion channel binding
0.37	GO:0071889	14-3-3 protein binding
0.37	GO:0030551	cyclic nucleotide binding
0.37	GO:0046982	protein heterodimerization activity
0.36	GO:0019901	protein kinase binding
0.36	GO:0042802	identical protein binding

0.59	GO:0005887	integral component of plasma membrane
0.48	GO:0031901	early endosome membrane
0.45	GO:0034705	potassium channel complex
0.40	GO:0009986	cell surface
0.39	GO:0042734	presynaptic membrane
0.38	GO:0043231	intracellular membrane-bounded organelle
0.38	GO:0043025	neuronal cell body
0.38	GO:0030425	dendrite
0.38	GO:0030424	axon
0.38	GO:0014069	postsynaptic density

0.65

GO:0000155

tr|T1EGN8|T1EGN8_HELRO
Uncharacterized protein
Search

0.42	Potassium voltage-gated channel protein Shab

0.77	GO:0051260	protein homooligomerization
0.76	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.45	GO:1900454	positive regulation of long term synaptic depression
0.45	GO:0090314	positive regulation of protein targeting to membrane
0.44	GO:0046676	negative regulation of insulin secretion
0.44	GO:0098900	regulation of action potential
0.44	GO:0001508	action potential
0.43	GO:0071333	cellular response to glucose stimulus
0.39	GO:0010701	positive regulation of norepinephrine secretion

0.78	GO:0005249	voltage-gated potassium channel activity
0.43	GO:0044325	ion channel binding
0.37	GO:0046982	protein heterodimerization activity
0.34	GO:0042162	telomeric DNA binding
0.33	GO:0042803	protein homodimerization activity

0.78	GO:0008076	voltage-gated potassium channel complex
0.45	GO:0032809	neuronal cell body membrane
0.43	GO:0030425	dendrite
0.39	GO:0043204	perikaryon
0.38	GO:0016328	lateral plasma membrane
0.37	GO:0042383	sarcolemma
0.37	GO:0030424	axon
0.37	GO:0045211	postsynaptic membrane
0.36	GO:0030054	cell junction
0.34	GO:0044214	spanning component of plasma membrane

tr|T1EGN9|T1EGN9_HELRO
Uncharacterized protein
Search

0.49	Chloride anion exchanger

0.75	GO:0008272	sulfate transport
0.72	GO:0098661	inorganic anion transmembrane transport
0.55	GO:0015701	bicarbonate transport
0.55	GO:0006885	regulation of pH
0.54	GO:0030004	cellular monovalent inorganic cation homeostasis
0.53	GO:0007605	sensory perception of sound
0.51	GO:0006821	chloride transport
0.51	GO:0019532	oxalate transport
0.48	GO:0042391	regulation of membrane potential
0.43	GO:0032880	regulation of protein localization

0.78	GO:0008271	secondary active sulfate transmembrane transporter activity
0.58	GO:0015301	anion:anion antiporter activity
0.51	GO:0015106	bicarbonate transmembrane transporter activity
0.51	GO:0019531	oxalate transmembrane transporter activity
0.47	GO:0015108	chloride transmembrane transporter activity
0.46	GO:0005253	anion channel activity
0.40	GO:0004930	G-protein coupled receptor activity
0.40	GO:0005509	calcium ion binding
0.38	GO:0015111	iodide transmembrane transporter activity
0.37	GO:0030507	spectrin binding

0.50	GO:0031526	brush border membrane
0.49	GO:0005887	integral component of plasma membrane
0.48	GO:0016324	apical plasma membrane
0.45	GO:0070062	extracellular exosome
0.41	GO:0016323	basolateral plasma membrane
0.40	GO:0097225	sperm midpiece
0.37	GO:0016328	lateral plasma membrane
0.35	GO:0012506	vesicle membrane
0.34	GO:0005783	endoplasmic reticulum
0.34	GO:0034707	chloride channel complex

tr|T1EGP0|T1EGP0_HELRO
Uncharacterized protein
Search

EXT1

0.85	Exostosin like glycosyltransferase 1

0.75	GO:0015012	heparan sulfate proteoglycan biosynthetic process
0.74	GO:0006486	protein glycosylation
0.54	GO:0072498	embryonic skeletal joint development
0.53	GO:0007411	axon guidance
0.53	GO:0021772	olfactory bulb development
0.52	GO:0007492	endoderm development
0.51	GO:0007498	mesoderm development
0.51	GO:0001503	ossification
0.51	GO:0007369	gastrulation
0.49	GO:0033692	cellular polysaccharide biosynthetic process

0.72	GO:0015020	glucuronosyltransferase activity
0.58	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
0.48	GO:0042803	protein homodimerization activity
0.48	GO:0046982	protein heterodimerization activity
0.43	GO:0004672	protein kinase activity
0.39	GO:0032559	adenyl ribonucleotide binding
0.39	GO:0008144	drug binding
0.39	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0046872	metal ion binding
0.35	GO:0042328	heparan sulfate N-acetylglucosaminyltransferase activity

0.62	GO:0005783	endoplasmic reticulum
0.49	GO:0005794	Golgi apparatus
0.48	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.46	GO:0031984	organelle subcompartment
0.41	GO:0045202	synapse
0.38	GO:0098588	bounding membrane of organelle
0.32	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

0.72

EC:2.4.1.17

GO:0015020

tr|T1EGP1|T1EGP1_HELRO
Uncharacterized protein
Search

0.10	Aminopeptidase

0.61	GO:0006508	proteolysis
0.51	GO:0008217	regulation of blood pressure
0.50	GO:0060177	regulation of angiotensin metabolic process
0.49	GO:0050886	endocrine process
0.46	GO:0042445	hormone metabolic process
0.45	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I
0.44	GO:0051604	protein maturation
0.42	GO:0006518	peptide metabolic process
0.39	GO:1901565	organonitrogen compound catabolic process
0.38	GO:0044248	cellular catabolic process

0.67	GO:0008237	metallopeptidase activity
0.66	GO:0004177	aminopeptidase activity
0.63	GO:0008270	zinc ion binding
0.42	GO:0042277	peptide binding
0.33	GO:0004126	cytidine deaminase activity
0.33	GO:0042802	identical protein binding

0.40	GO:0005783	endoplasmic reticulum
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0044446	intracellular organelle part
0.36	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0031982	vesicle
0.35	GO:0000793	condensed chromosome
0.34	GO:0015630	microtubule cytoskeleton
0.34	GO:0071944	cell periphery
0.34	GO:0031090	organelle membrane
0.33	GO:0043230	extracellular organelle

0.66

EC:3.4.11

GO:0004177

tr|T1EGP2|T1EGP2_HELRO
Uncharacterized protein
Search

PTEN

0.88	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

0.78	GO:0051895	negative regulation of focal adhesion assembly
0.76	GO:0051898	negative regulation of protein kinase B signaling
0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.72	GO:0030336	negative regulation of cell migration
0.71	GO:0046856	phosphatidylinositol dephosphorylation
0.70	GO:0046855	inositol phosphate dephosphorylation
0.70	GO:0008285	negative regulation of cell proliferation
0.70	GO:0031647	regulation of protein stability
0.50	GO:0001568	blood vessel development
0.50	GO:0051093	negative regulation of developmental process

0.80	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
0.80	GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
0.78	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.75	GO:0030165	PDZ domain binding
0.75	GO:0004725	protein tyrosine phosphatase activity
0.58	GO:0000287	magnesium ion binding
0.51	GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
0.48	GO:0004438	phosphatidylinositol-3-phosphatase activity
0.48	GO:1990381	ubiquitin-specific protease binding
0.46	GO:0042577	lipid phosphatase activity

0.48	GO:0035749	myelin sheath adaxonal region
0.48	GO:0043220	Schmidt-Lanterman incisure
0.46	GO:0016324	apical plasma membrane
0.44	GO:0043005	neuron projection
0.44	GO:0009898	cytoplasmic side of plasma membrane
0.43	GO:0005654	nucleoplasm
0.42	GO:0005829	cytosol
0.37	GO:0036477	somatodendritic compartment
0.37	GO:0045211	postsynaptic membrane
0.37	GO:0120038	plasma membrane bounded cell projection part

0.80

EC:3.1.3.67

GO:0016314

tr|T1EGP3|T1EGP3_HELRO
Uncharacterized protein
Search

PPP1R16A

0.71	Alanine aminotransferase 1

0.77	GO:0043666	regulation of phosphoprotein phosphatase activity
0.69	GO:1902309	negative regulation of peptidyl-serine dephosphorylation
0.68	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
0.65	GO:0061028	establishment of endothelial barrier
0.64	GO:0035307	positive regulation of protein dephosphorylation
0.64	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling
0.43	GO:0051489	regulation of filopodium assembly
0.33	GO:0055114	oxidation-reduction process
0.33	GO:0009058	biosynthetic process

0.78	GO:0019888	protein phosphatase regulator activity
0.37	GO:0008113	peptide-methionine (S)-S-oxide reductase activity
0.36	GO:0005515	protein binding
0.35	GO:0070279	vitamin B6 binding
0.34	GO:0050662	coenzyme binding
0.33	GO:0043168	anion binding

0.60	GO:0016607	nuclear speck
0.60	GO:0048471	perinuclear region of cytoplasm
0.53	GO:0042995	cell projection
0.46	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.37

EC:1.8.4 EC:1.8.4.11

GO:0008113

tr|T1EGP4|T1EGP4_HELRO
Uncharacterized protein
Search

0.89	gastrin/cholecystokinin type B receptor-like

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.40	GO:1901652	response to peptide
0.39	GO:0032870	cellular response to hormone stimulus
0.36	GO:0007267	cell-cell signaling
0.36	GO:0007631	feeding behavior
0.35	GO:0007399	nervous system development
0.34	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.34	GO:0060322	head development
0.34	GO:0000904	cell morphogenesis involved in differentiation
0.34	GO:0016477	cell migration

0.72	GO:0004930	G-protein coupled receptor activity
0.64	GO:0001653	peptide receptor activity
0.41	GO:0042277	peptide binding
0.33	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.33	GO:0009881	photoreceptor activity
0.33	GO:0016500	protein-hormone receptor activity

0.39	GO:0005887	integral component of plasma membrane
0.35	GO:0043005	neuron projection
0.31	GO:0005622	intracellular

0.33

GO:0004715

tr|T1EGP5|T1EGP5_HELRO
Uncharacterized protein
Search

0.75	Hyperpolarizaion-activated cyclic nucleotide-gated cation channel

0.66	GO:0071805	potassium ion transmembrane transport
0.58	GO:0034765	regulation of ion transmembrane transport
0.47	GO:0006814	sodium ion transport
0.45	GO:0002027	regulation of heart rate
0.43	GO:0042391	regulation of membrane potential
0.38	GO:0071320	cellular response to cAMP
0.38	GO:0035677	posterior lateral line neuromast hair cell development
0.38	GO:0071321	cellular response to cGMP
0.38	GO:0007270	neuron-neuron synaptic transmission
0.37	GO:0099587	inorganic ion import across plasma membrane

0.70	GO:0005249	voltage-gated potassium channel activity
0.51	GO:0030552	cAMP binding
0.39	GO:0005222	intracellular cAMP activated cation channel activity
0.38	GO:0005248	voltage-gated sodium channel activity
0.36	GO:0042802	identical protein binding
0.35	GO:0004692	cGMP-dependent protein kinase activity
0.34	GO:0030165	PDZ domain binding
0.34	GO:0032947	protein complex scaffold activity
0.34	GO:0032403	protein complex binding
0.32	GO:0003676	nucleic acid binding

0.43	GO:0005887	integral component of plasma membrane
0.37	GO:0034705	potassium channel complex
0.35	GO:0030425	dendrite
0.35	GO:0030424	axon
0.34	GO:0032589	neuron projection membrane
0.34	GO:0043025	neuronal cell body
0.34	GO:0045202	synapse
0.32	GO:0005737	cytoplasm

0.35

EC:2.7.11.12

GO:0004692

tr|T1EGP6|T1EGP6_HELRO
Uncharacterized protein
Search

0.77	Polo like kinase 2

0.63	GO:0006468	protein phosphorylation
0.50	GO:0046599	regulation of centriole replication
0.49	GO:0007613	memory
0.49	GO:0000082	G1/S transition of mitotic cell cycle
0.48	GO:0016525	negative regulation of angiogenesis
0.48	GO:0048167	regulation of synaptic plasticity
0.48	GO:0007052	mitotic spindle organization
0.48	GO:0018209	peptidyl-serine modification
0.48	GO:0045732	positive regulation of protein catabolic process
0.47	GO:0010508	positive regulation of autophagy

0.64	GO:0004672	protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.52	GO:0043008	ATP-dependent protein binding
0.37	GO:0032403	protein complex binding
0.35	GO:0019237	centromeric DNA binding
0.34	GO:0051219	phosphoprotein binding
0.34	GO:0008047	enzyme activator activity

0.48	GO:0005814	centriole
0.47	GO:0005813	centrosome
0.45	GO:0000785	chromatin
0.38	GO:0030425	dendrite
0.35	GO:0097431	mitotic spindle pole
0.35	GO:1990023	mitotic spindle midzone
0.35	GO:0044732	mitotic spindle pole body
0.34	GO:0005935	cellular bud neck
0.33	GO:0005634	nucleus
0.33	GO:0005829	cytosol

tr|T1EGP7|T1EGP7_HELRO
Uncharacterized protein
Search

0.42	GO:0009952	anterior/posterior pattern specification
0.41	GO:0007492	endoderm development
0.40	GO:0006338	chromatin remodeling
0.40	GO:0006357	regulation of transcription by RNA polymerase II
0.40	GO:0007420	brain development
0.39	GO:0045893	positive regulation of transcription, DNA-templated
0.38	GO:0045892	negative regulation of transcription, DNA-templated
0.37	GO:0034728	nucleosome organization
0.37	GO:0060897	neural plate regionalization
0.36	GO:0006351	transcription, DNA-templated

0.78	GO:0140034	methylation-dependent protein binding
0.74	GO:0042393	histone binding
0.54	GO:0046872	metal ion binding
0.39	GO:0008134	transcription factor binding
0.38	GO:0043565	sequence-specific DNA binding
0.38	GO:0008094	DNA-dependent ATPase activity
0.36	GO:0003682	chromatin binding
0.36	GO:0001047	core promoter binding
0.36	GO:0070615	nucleosome-dependent ATPase activity
0.36	GO:0140033	acetylation-dependent protein binding

0.78	GO:0016589	NURF complex
0.40	GO:0048188	Set1C/COMPASS complex
0.33	GO:0000808	origin recognition complex
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.31

GO:0008168

tr|T1EGP8|T1EGP8_HELRO
Uncharacterized protein
Search

0.61	GO:0006359	regulation of transcription by RNA polymerase III
0.60	GO:0006383	transcription by RNA polymerase III
0.48	GO:0006266	DNA ligation
0.44	GO:0071897	DNA biosynthetic process
0.43	GO:0006310	DNA recombination
0.43	GO:0006281	DNA repair
0.39	GO:0009303	rRNA transcription
0.39	GO:0009304	tRNA transcription
0.37	GO:0034729	histone H3-K79 methylation
0.36	GO:0051726	regulation of cell cycle

0.62	GO:0000995	transcription factor activity, core RNA polymerase III binding
0.48	GO:0003910	DNA ligase (ATP) activity
0.40	GO:0003677	DNA binding
0.40	GO:0032559	adenyl ribonucleotide binding
0.39	GO:0008144	drug binding
0.39	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0031151	histone methyltransferase activity (H3-K79 specific)
0.35	GO:0005515	protein binding
0.34	GO:0003964	RNA-directed DNA polymerase activity

0.82	GO:0000127	transcription factor TFIIIC complex
0.70	GO:0031965	nuclear membrane
0.64	GO:0005730	nucleolus
0.36	GO:0005654	nucleoplasm
0.30	GO:0016021	integral component of membrane

0.48

EC:6.5.1.1

GO:0003910

tr|T1EGP9|T1EGP9_HELRO
Uncharacterized protein
Search

0.23	Membrane-bound O-acyltransferase domain-containing protein 2

0.39	GO:0007291	sperm individualization
0.39	GO:0008354	germ cell migration
0.38	GO:0007009	plasma membrane organization
0.36	GO:0030258	lipid modification
0.32	GO:0055085	transmembrane transport

0.48

GO:0016746

transferase activity, transferring acyl groups

0.30

GO:0031224

intrinsic component of membrane

0.48

EC:2.3

GO:0016746

tr|T1EGQ0|T1EGQ0_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.41	GO:0007399	nervous system development
0.39	GO:0007267	cell-cell signaling
0.38	GO:0007605	sensory perception of sound
0.38	GO:0048513	animal organ development
0.37	GO:0007626	locomotory behavior
0.37	GO:0016043	cellular component organization
0.36	GO:0030154	cell differentiation
0.36	GO:0060471	cortical granule exocytosis
0.35	GO:0007163	establishment or maintenance of cell polarity

0.70

GO:0005509

calcium ion binding

0.56	GO:0005886	plasma membrane
0.39	GO:0098858	actin-based cell projection
0.38	GO:0032421	stereocilium bundle
0.37	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0043005	neuron projection
0.36	GO:0005911	cell-cell junction
0.35	GO:0030027	lamellipodium
0.35	GO:0043226	organelle
0.33	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

tr|T1EGQ1|T1EGQ1_HELRO
Uncharacterized protein
Search

MORC2

0.70	MORC family CW-type zinc finger protein 2

0.39	GO:0044026	DNA hypermethylation
0.39	GO:2000143	negative regulation of DNA-templated transcription, initiation
0.38	GO:0043046	DNA methylation involved in gamete generation
0.38	GO:0010529	negative regulation of transposition
0.37	GO:0007283	spermatogenesis
0.37	GO:0040029	regulation of gene expression, epigenetic
0.33	GO:0006631	fatty acid metabolic process
0.33	GO:0030154	cell differentiation
0.33	GO:0007275	multicellular organism development
0.32	GO:0055114	oxidation-reduction process

0.61	GO:0008270	zinc ion binding
0.32	GO:0016491	oxidoreductase activity

0.45	GO:0005829	cytosol
0.44	GO:0005634	nucleus

0.32

GO:0016491

tr|T1EGQ2|T1EGQ2_HELRO
Uncharacterized protein
Search

0.65	Vasoactive intestinal peptide receptor 2 (Fragment)

0.71	GO:0007166	cell surface receptor signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.63	GO:0009755	hormone-mediated signaling pathway
0.37	GO:0007190	activation of adenylate cyclase activity
0.37	GO:0048662	negative regulation of smooth muscle cell proliferation
0.34	GO:0002121	inter-male aggressive behavior
0.33	GO:0007267	cell-cell signaling

0.72	GO:0008036	diuretic hormone receptor activity
0.72	GO:0004930	G-protein coupled receptor activity
0.35	GO:0001653	peptide receptor activity

0.50	GO:0005886	plasma membrane
0.40	GO:0005881	cytoplasmic microtubule
0.36	GO:0043235	receptor complex
0.33	GO:0005929	cilium
0.30	GO:0031224	intrinsic component of membrane

tr|T1EGQ3|T1EGQ3_HELRO
Uncharacterized protein
Search

0.73	GO:0007218	neuropeptide signaling pathway
0.47	GO:1901652	response to peptide
0.45	GO:0071495	cellular response to endogenous stimulus
0.45	GO:0071310	cellular response to organic substance
0.44	GO:0009725	response to hormone
0.44	GO:0002430	complement receptor mediated signaling pathway
0.44	GO:0007631	feeding behavior
0.42	GO:0051480	regulation of cytosolic calcium ion concentration
0.42	GO:0022410	circadian sleep/wake cycle process
0.40	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway

0.75	GO:0008188	neuropeptide receptor activity
0.48	GO:0042277	peptide binding
0.46	GO:0016499	orexin receptor activity
0.44	GO:0004875	complement receptor activity
0.39	GO:0001847	opsonin receptor activity
0.39	GO:0004982	N-formyl peptide receptor activity
0.38	GO:0005124	scavenger receptor binding
0.38	GO:0042562	hormone binding
0.37	GO:0008227	G-protein coupled amine receptor activity
0.36	GO:0015464	acetylcholine receptor activity

0.42	GO:0005887	integral component of plasma membrane
0.33	GO:0005737	cytoplasm

tr|T1EGQ4|T1EGQ4_HELRO
Uncharacterized protein
Search

0.44	Carboxylic ester hydrolase

0.35

GO:0042135

neurotransmitter catabolic process

0.84

GO:0004104

cholinesterase activity

0.35	GO:0045202	synapse
0.35	GO:0030054	cell junction
0.33	GO:0005576	extracellular region
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.84

GO:0004104

tr|T1EGQ5|T1EGQ5_HELRO
Uncharacterized protein
Search

0.59	Solute carrier family 39 (Iron-regulated transporter), member 1

0.78	GO:0034755	iron ion transmembrane transport
0.53	GO:0060345	spleen trabecula formation
0.53	GO:1903414	iron cation export
0.52	GO:0070839	divalent metal ion export
0.51	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron
0.51	GO:0060586	multicellular organismal iron ion homeostasis
0.49	GO:0006879	cellular iron ion homeostasis
0.49	GO:0002260	lymphocyte homeostasis
0.49	GO:0003158	endothelium development
0.48	GO:0140115	export across plasma membrane

0.78	GO:0005381	iron ion transmembrane transporter activity
0.54	GO:0017046	peptide hormone binding
0.47	GO:0072509	divalent inorganic cation transmembrane transporter activity
0.45	GO:0005261	cation channel activity
0.45	GO:0042802	identical protein binding
0.42	GO:0004872	receptor activity
0.34	GO:0008417	fucosyltransferase activity
0.32	GO:0015087	cobalt ion transmembrane transporter activity
0.31	GO:0046872	metal ion binding

0.52	GO:0016323	basolateral plasma membrane
0.48	GO:0008021	synaptic vesicle
0.46	GO:0005654	nucleoplasm
0.46	GO:0005829	cytosol
0.34	GO:0032580	Golgi cisterna membrane
0.33	GO:0005887	integral component of plasma membrane
0.32	GO:0009705	plant-type vacuole membrane

0.34

GO:0008417

tr|T1EGQ6|T1EGQ6_HELRO
Uncharacterized protein
Search

tr|T1EGQ7|T1EGQ7_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.52	GO:0007186	G-protein coupled receptor signaling pathway
0.51	GO:0007166	cell surface receptor signaling pathway
0.38	GO:0072137	condensed mesenchymal cell proliferation
0.37	GO:0048731	system development
0.36	GO:0001736	establishment of planar polarity
0.36	GO:0060269	centripetally migrating follicle cell migration
0.35	GO:1902463	protein localization to cell leading edge
0.35	GO:0035239	tube morphogenesis
0.35	GO:0007163	establishment or maintenance of cell polarity

0.70	GO:0005509	calcium ion binding
0.52	GO:0004930	G-protein coupled receptor activity
0.35	GO:0050839	cell adhesion molecule binding
0.34	GO:0004022	alcohol dehydrogenase (NAD) activity
0.34	GO:0008417	fucosyltransferase activity
0.34	GO:0032403	protein complex binding

0.56	GO:0005886	plasma membrane
0.35	GO:0031254	cell trailing edge
0.35	GO:0045178	basal part of cell
0.35	GO:0032797	SMN complex
0.35	GO:0098858	actin-based cell projection
0.34	GO:0005925	focal adhesion
0.34	GO:0032580	Golgi cisterna membrane
0.30	GO:0016021	integral component of membrane

0.34

EC:1.1.1.1

GO:0004022

tr|T1EGQ8|T1EGQ8_HELRO
Uncharacterized protein
Search

0.48	Disintegrin and metalloproteinase domain-containing protein 12

0.61	GO:0007229	integrin-mediated signaling pathway
0.60	GO:0006508	proteolysis
0.40	GO:0051259	protein oligomerization
0.32	GO:0009405	pathogenesis

0.70	GO:0004222	metalloendopeptidase activity
0.54	GO:0046872	metal ion binding
0.40	GO:0042802	identical protein binding
0.35	GO:0017124	SH3 domain binding
0.32	GO:0090729	toxin activity

0.40	GO:0098595	perivitelline space
0.34	GO:0005794	Golgi apparatus
0.30	GO:0031224	intrinsic component of membrane

0.70

GO:0004222

tr|T1EGQ9|T1EGQ9_HELRO
Uncharacterized protein
Search

CLPX

0.40	Caseinolytic mitochondrial matrix peptidase chaperone subunit b

0.69	GO:0006457	protein folding
0.54	GO:0006508	proteolysis
0.43	GO:0030163	protein catabolic process
0.43	GO:0010952	positive regulation of peptidase activity
0.40	GO:0044265	cellular macromolecule catabolic process
0.38	GO:0046034	ATP metabolic process
0.36	GO:0044267	cellular protein metabolic process
0.35	GO:0048821	erythrocyte development

0.71	GO:0051082	unfolded protein binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008233	peptidase activity
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0016504	peptidase activator activity
0.41	GO:0042623	ATPase activity, coupled
0.36	GO:0046983	protein dimerization activity
0.36	GO:0008270	zinc ion binding
0.34	GO:0017171	serine hydrolase activity

0.46	GO:0009841	mitochondrial endopeptidase Clp complex
0.43	GO:0042645	mitochondrial nucleoid
0.40	GO:0005654	nucleoplasm
0.40	GO:0005829	cytosol
0.38	GO:0031966	mitochondrial membrane
0.38	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.54

GO:0008233

tr|T1EGR0|T1EGR0_HELRO
Uncharacterized protein
Search

0.42	Membrane-bound O-acyltransferase domain-containing protein 2

0.49	GO:0007291	sperm individualization
0.49	GO:0008354	germ cell migration
0.47	GO:0007009	plasma membrane organization
0.44	GO:0030258	lipid modification
0.32	GO:0055085	transmembrane transport

0.48

GO:0016746

transferase activity, transferring acyl groups

0.30

GO:0031224

intrinsic component of membrane

0.48

EC:2.3

GO:0016746

tr|T1EGR1|T1EGR1_HELRO
Uncharacterized protein
Search

0.74	GO:0016055	Wnt signaling pathway
0.69	GO:0007275	multicellular organism development
0.61	GO:1904394	negative regulation of skeletal muscle acetylcholine-gated channel clustering
0.59	GO:1990523	bone regeneration
0.58	GO:0071157	negative regulation of cell cycle arrest
0.57	GO:2000179	positive regulation of neural precursor cell proliferation
0.57	GO:0030501	positive regulation of bone mineralization
0.56	GO:0043524	negative regulation of neuron apoptotic process
0.56	GO:0072089	stem cell proliferation
0.56	GO:0061351	neural precursor cell proliferation

0.68	GO:0004888	transmembrane signaling receptor activity
0.59	GO:0017147	Wnt-protein binding
0.52	GO:0042803	protein homodimerization activity
0.51	GO:0046982	protein heterodimerization activity
0.39	GO:0004252	serine-type endopeptidase activity
0.38	GO:0005044	scavenger receptor activity
0.34	GO:0042393	histone binding
0.33	GO:0016887	ATPase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0008144	drug binding

0.58	GO:0031527	filopodium membrane
0.53	GO:0048471	perinuclear region of cytoplasm
0.52	GO:0009986	cell surface
0.37	GO:0005789	endoplasmic reticulum membrane
0.37	GO:0005794	Golgi apparatus
0.37	GO:0005576	extracellular region
0.36	GO:0031966	mitochondrial membrane
0.36	GO:0031981	nuclear lumen
0.34	GO:0000785	chromatin
0.33	GO:1904949	ATPase complex

0.39

GO:0004252

tr|T1EGR2|T1EGR2_HELRO
Uncharacterized protein
Search

HEXDC

0.41	Hexosaminidase D (inferred by orthology to a human protein)

0.59	GO:0005975	carbohydrate metabolic process
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:0010468	regulation of gene expression

0.66	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.35	GO:0043565	sequence-specific DNA binding
0.34	GO:0003700	DNA binding transcription factor activity

0.34	GO:0005634	nucleus
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.66

GO:0004553

tr|T1EGR3|T1EGR3_HELRO
Uncharacterized protein
Search

0.78	GO:0016573	histone acetylation
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:0007464	R3/R4 cell fate commitment
0.50	GO:0040040	thermosensory behavior
0.50	GO:0045466	R7 cell differentiation
0.49	GO:0045475	locomotor rhythm
0.49	GO:0008347	glial cell migration
0.49	GO:0000076	DNA replication checkpoint

0.80	GO:0004402	histone acetyltransferase activity
0.75	GO:0003712	transcription cofactor activity
0.63	GO:0008270	zinc ion binding
0.51	GO:1990226	histone methyltransferase binding
0.48	GO:0042800	histone methyltransferase activity (H3-K4 specific)
0.45	GO:0008134	transcription factor binding
0.35	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
0.33	GO:0016849	phosphorus-oxygen lyase activity
0.32	GO:1901265	nucleoside phosphate binding
0.32	GO:0036094	small molecule binding

0.66	GO:0000123	histone acetyltransferase complex
0.48	GO:0005700	polytene chromosome
0.46	GO:0035097	histone methyltransferase complex
0.46	GO:0098793	presynapse
0.40	GO:0043234	protein complex
0.34	GO:0005681	spliceosomal complex
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.80

GO:0004402

tr|T1EGR4|T1EGR4_HELRO
Uncharacterized protein
Search

0.79	Potassium voltage-gated channel protein Shaker

0.77	GO:0051260	protein homooligomerization
0.77	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.44	GO:0086052	membrane repolarization during SA node cell action potential
0.44	GO:0086050	membrane repolarization during bundle of His cell action potential
0.44	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential
0.43	GO:0060081	membrane hyperpolarization
0.43	GO:0086091	regulation of heart rate by cardiac conduction
0.42	GO:0043267	negative regulation of potassium ion transport
0.41	GO:0019229	regulation of vasoconstriction

0.78	GO:0005249	voltage-gated potassium channel activity
0.43	GO:0019870	potassium channel inhibitor activity
0.43	GO:0051393	alpha-actinin binding
0.42	GO:0097110	scaffold protein binding
0.41	GO:0019901	protein kinase binding
0.40	GO:0030955	potassium ion binding
0.33	GO:0005102	receptor binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.42	GO:0014704	intercalated disc
0.41	GO:0045121	membrane raft
0.36	GO:0030424	axon
0.36	GO:0120038	plasma membrane bounded cell projection part
0.36	GO:0098889	intrinsic component of presynaptic membrane
0.35	GO:0098936	intrinsic component of postsynaptic membrane
0.35	GO:0099699	integral component of synaptic membrane
0.35	GO:0044309	neuron spine
0.35	GO:0032279	asymmetric synapse

tr|T1EGR5|T1EGR5_HELRO
Uncharacterized protein
Search

tr|T1EGR6|T1EGR6_HELRO
Uncharacterized protein
Search

0.87	INDR type dopamine receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.60	GO:0042310	vasoconstriction
0.60	GO:0007210	serotonin receptor signaling pathway
0.60	GO:0050795	regulation of behavior
0.59	GO:0046883	regulation of hormone secretion
0.57	GO:0008283	cell proliferation
0.48	GO:0014062	regulation of serotonin secretion
0.48	GO:0042053	regulation of dopamine metabolic process
0.47	GO:0042428	serotonin metabolic process
0.47	GO:0035640	exploration behavior

0.72	GO:0004930	G-protein coupled receptor activity
0.60	GO:0099589	serotonin receptor activity
0.60	GO:0030594	neurotransmitter receptor activity
0.48	GO:0090722	receptor-receptor interaction
0.42	GO:0051378	serotonin binding
0.36	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.33	GO:0001965	G-protein alpha-subunit binding
0.33	GO:0035586	purinergic receptor activity
0.32	GO:0008144	drug binding

0.52	GO:0005887	integral component of plasma membrane
0.34	GO:0030285	integral component of synaptic vesicle membrane
0.33	GO:0043203	axon hillock

0.36

GO:0004715

tr|T1EGR7|T1EGR7_HELRO
Uncharacterized protein
Search

0.45	Polypeptide N-acetylgalactosaminyltransferase

0.71	GO:0043413	macromolecule glycosylation
0.71	GO:0009101	glycoprotein biosynthetic process
0.58	GO:0006464	cellular protein modification process
0.39	GO:0009312	oligosaccharide biosynthetic process

0.67	GO:0030246	carbohydrate binding
0.63	GO:0016757	transferase activity, transferring glycosyl groups
0.38	GO:0140096	catalytic activity, acting on a protein
0.35	GO:0005112	Notch binding
0.34	GO:0046872	metal ion binding

0.71	GO:0000139	Golgi membrane
0.35	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0005795	Golgi stack
0.30	GO:0031224	intrinsic component of membrane

0.63

GO:0016757

tr|T1EGR8|T1EGR8_HELRO
Uncharacterized protein
Search

0.59	Polypeptide N-acetylgalactosaminyltransferase

0.73	GO:0006486	protein glycosylation
0.39	GO:0018210	peptidyl-threonine modification
0.36	GO:0007286	spermatid development
0.35	GO:0009312	oligosaccharide biosynthetic process

0.68	GO:0030246	carbohydrate binding
0.64	GO:0016757	transferase activity, transferring glycosyl groups
0.40	GO:0140096	catalytic activity, acting on a protein
0.39	GO:0005112	Notch binding
0.33	GO:0046872	metal ion binding

0.71	GO:0000139	Golgi membrane
0.33	GO:0005795	Golgi stack
0.30	GO:0031224	intrinsic component of membrane

0.64

GO:0016757

tr|T1EGR9|T1EGR9_HELRO
Uncharacterized protein
Search

0.55	N6-adenosine-methyltransferase 70 kDa subunit

0.77	GO:0080009	mRNA methylation
0.56	GO:1990744	primary miRNA methylation
0.53	GO:1903677	regulation of cap-independent translational initiation
0.53	GO:1904690	positive regulation of cytoplasmic translational initiation
0.50	GO:0034644	cellular response to UV
0.48	GO:0000398	mRNA splicing, via spliceosome
0.47	GO:0008593	regulation of Notch signaling pathway
0.46	GO:0030708	germarium-derived female germ-line cyst encapsulation
0.46	GO:0030237	female sex determination
0.45	GO:0007549	dosage compensation

0.85	GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
0.48	GO:1904047	S-adenosyl-L-methionine binding
0.47	GO:0003729	mRNA binding
0.47	GO:0001734	mRNA (N6-adenosine)-methyltransferase activity
0.46	GO:0046982	protein heterodimerization activity
0.34	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
0.34	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.59	GO:0005634	nucleus
0.58	GO:0036396	RNA N6-methyladenosine methyltransferase complex
0.45	GO:0070013	intracellular organelle lumen
0.41	GO:0044446	intracellular organelle part
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.85

EC:2.1.1.62

GO:0016422

tr|T1EGS0|T1EGS0_HELRO
Uncharacterized protein
Search

0.72	Mitochondrial ribosomal protein L3

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process

0.64	GO:0003735	structural constituent of ribosome
0.45	GO:0019843	rRNA binding

0.61	GO:0005840	ribosome
0.37	GO:0005759	mitochondrial matrix
0.30	GO:0016021	integral component of membrane

tr|T1EGS1|T1EGS1_HELRO
Uncharacterized protein
Search

0.60	Ypt/rab specific gtpase activating protein gyp1

0.79	GO:0031338	regulation of vesicle fusion
0.79	GO:0090630	activation of GTPase activity
0.65	GO:0006886	intracellular protein transport
0.45	GO:0033522	histone H2A ubiquitination
0.45	GO:0033523	histone H2B ubiquitination
0.44	GO:0045739	positive regulation of DNA repair
0.44	GO:0010212	response to ionizing radiation
0.43	GO:0080009	mRNA methylation
0.42	GO:0006302	double-strand break repair
0.42	GO:0006370	7-methylguanosine mRNA capping

0.76	GO:0017137	Rab GTPase binding
0.71	GO:0005096	GTPase activator activity
0.57	GO:0071889	14-3-3 protein binding
0.47	GO:0042803	protein homodimerization activity
0.44	GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity
0.43	GO:0043130	ubiquitin binding
0.43	GO:0042393	histone binding
0.42	GO:0003682	chromatin binding
0.41	GO:0004842	ubiquitin-protein transferase activity
0.36	GO:0046872	metal ion binding

0.65	GO:0012505	endomembrane system
0.44	GO:0005622	intracellular
0.44	GO:0030496	midbody
0.43	GO:0043227	membrane-bounded organelle
0.40	GO:1990234	transferase complex
0.38	GO:0043228	non-membrane-bounded organelle
0.37	GO:0044422	organelle part

0.44	EC:2.1.1.57	GO:0004483
0.41	KEGG:R03876	GO:0004842

tr|T1EGS2|T1EGS2_HELRO
Uncharacterized protein
Search

0.56	Two pore potassium channel protein sup-9

0.67	GO:0071805	potassium ion transmembrane transport
0.42	GO:0030322	stabilization of membrane potential
0.39	GO:0042321	negative regulation of circadian sleep/wake cycle, sleep
0.39	GO:0045837	negative regulation of membrane potential
0.39	GO:1903351	cellular response to dopamine
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.70	GO:0005267	potassium channel activity
0.42	GO:0022840	leak channel activity
0.32	GO:0003723	RNA binding

0.38	GO:0005887	integral component of plasma membrane
0.32	GO:0005634	nucleus

tr|T1EGS3|T1EGS3_HELRO
Uncharacterized protein
Search

GABRB1

0.90	Gamma-aminobutyric acid receptor subunit beta-1

0.61	GO:0007165	signal transduction
0.60	GO:0034220	ion transmembrane transport
0.47	GO:0006821	chloride transport
0.40	GO:0071420	cellular response to histamine
0.39	GO:0032570	response to progesterone
0.38	GO:0021954	central nervous system neuron development
0.38	GO:0042698	ovulation cycle
0.36	GO:0009636	response to toxic substance
0.34	GO:0043058	regulation of backward locomotion
0.34	GO:0060012	synaptic transmission, glycinergic

0.76	GO:0005230	extracellular ligand-gated ion channel activity
0.70	GO:0004890	GABA-A receptor activity
0.51	GO:0099095	ligand-gated anion channel activity
0.47	GO:0005254	chloride channel activity
0.47	GO:0022835	transmitter-gated channel activity
0.39	GO:0050811	GABA receptor binding
0.35	GO:0016594	glycine binding
0.33	GO:0044877	macromolecular complex binding
0.32	GO:0004674	protein serine/threonine kinase activity
0.32	GO:0004252	serine-type endopeptidase activity

0.55	GO:0005886	plasma membrane
0.54	GO:1902711	GABA-A receptor complex
0.38	GO:0098794	postsynapse
0.38	GO:0030425	dendrite
0.37	GO:0034707	chloride channel complex
0.37	GO:0005635	nuclear envelope
0.36	GO:0030054	cell junction
0.34	GO:0031594	neuromuscular junction
0.33	GO:0005737	cytoplasm
0.33	GO:0005654	nucleoplasm

0.32

GO:0004674

tr|T1EGS4|T1EGS4_HELRO
Uncharacterized protein
Search

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.42	GO:0095500	acetylcholine receptor signaling pathway
0.39	GO:0019933	cAMP-mediated signaling
0.39	GO:0007210	serotonin receptor signaling pathway
0.36	GO:0007267	cell-cell signaling
0.36	GO:0018108	peptidyl-tyrosine phosphorylation

0.72	GO:0004930	G-protein coupled receptor activity
0.48	GO:0030594	neurotransmitter receptor activity
0.39	GO:0099589	serotonin receptor activity
0.39	GO:0051378	serotonin binding
0.37	GO:0001653	peptide receptor activity
0.36	GO:0004715	non-membrane spanning protein tyrosine kinase activity

0.44	GO:0005887	integral component of plasma membrane
0.33	GO:0005622	intracellular

0.36

GO:0004715

tr|T1EGS5|T1EGS5_HELRO
Uncharacterized protein
Search

TACR3

0.60	Urechistachykinin receptor

0.85	GO:0007217	tachykinin receptor signaling pathway
0.53	GO:1902093	positive regulation of flagellated sperm motility
0.39	GO:0042220	response to cocaine
0.39	GO:0007218	neuropeptide signaling pathway
0.38	GO:0045987	positive regulation of smooth muscle contraction
0.38	GO:0070472	regulation of uterine smooth muscle contraction
0.38	GO:0043278	response to morphine
0.38	GO:0042053	regulation of dopamine metabolic process
0.38	GO:0010460	positive regulation of heart rate
0.38	GO:0045777	positive regulation of blood pressure

0.85	GO:0004995	tachykinin receptor activity
0.37	GO:0050254	rhodopsin kinase activity
0.35	GO:0004983	neuropeptide Y receptor activity
0.33	GO:0005515	protein binding

0.55	GO:0005886	plasma membrane
0.52	GO:0097225	sperm midpiece
0.37	GO:0043025	neuronal cell body
0.37	GO:0030425	dendrite
0.36	GO:0031252	cell leading edge
0.34	GO:0005634	nucleus
0.33	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.37

EC:2.7.11.14

GO:0050254

tr|T1EGS6|T1EGS6_HELRO
Uncharacterized protein
Search

0.51	Preprotein translocase subunit YidC

0.76	GO:0051205	protein insertion into membrane
0.49	GO:0015031	protein transport
0.36	GO:0008535	respiratory chain complex IV assembly
0.35	GO:0090151	establishment of protein localization to mitochondrial membrane
0.35	GO:0007007	inner mitochondrial membrane organization
0.34	GO:1990542	mitochondrial transmembrane transport
0.34	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly
0.33	GO:0097034	mitochondrial respiratory chain complex IV biogenesis
0.33	GO:0046907	intracellular transport
0.33	GO:0033108	mitochondrial respiratory chain complex assembly

0.34	GO:0097177	mitochondrial ribosome binding
0.34	GO:0032977	membrane insertase activity
0.33	GO:0005216	ion channel activity
0.32	GO:0003677	DNA binding

0.44	GO:0005886	plasma membrane
0.35	GO:0005739	mitochondrion
0.35	GO:0031967	organelle envelope
0.34	GO:0031090	organelle membrane
0.34	GO:0098805	whole membrane
0.34	GO:0019867	outer membrane
0.33	GO:0000315	organellar large ribosomal subunit
0.32	GO:0031974	membrane-enclosed lumen
0.30	GO:0031224	intrinsic component of membrane

tr|T1EGS7|T1EGS7_HELRO
Uncharacterized protein
Search

0.10	Dopamine receptor 1 (Fragment)

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.37	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration
0.36	GO:0090328	regulation of olfactory learning
0.36	GO:1990834	response to odorant
0.36	GO:0071329	cellular response to sucrose stimulus
0.36	GO:0043052	thermotaxis
0.36	GO:0040040	thermosensory behavior
0.36	GO:0008355	olfactory learning
0.36	GO:0008542	visual learning
0.35	GO:0007613	memory

0.72	GO:0004930	G-protein coupled receptor activity
0.58	GO:0030594	neurotransmitter receptor activity
0.35	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.34	GO:0001653	peptide receptor activity

0.52	GO:0005887	integral component of plasma membrane
0.35	GO:0098793	presynapse
0.32	GO:0005622	intracellular

0.35

GO:0004715

tr|T1EGS8|T1EGS8_HELRO
Uncharacterized protein
Search

CA10

0.68	Carbonic anhydrase 2

0.57	GO:0006730	one-carbon metabolic process
0.35	GO:0015701	bicarbonate transport
0.34	GO:0007420	brain development
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression
0.33	GO:0015671	oxygen transport

0.67	GO:0004089	carbonate dehydratase activity
0.51	GO:0008270	zinc ion binding
0.34	GO:0003700	DNA binding transcription factor activity
0.33	GO:0005344	oxygen carrier activity
0.33	GO:0019825	oxygen binding
0.32	GO:0020037	heme binding

0.49	GO:0016323	basolateral plasma membrane
0.37	GO:0005576	extracellular region
0.33	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.67

EC:4.2.1.1

GO:0004089

tr|T1EGS9|T1EGS9_HELRO
Uncharacterized protein
Search

0.85	GO:0051694	pointed-end actin filament capping
0.84	GO:0030239	myofibril assembly
0.82	GO:0006936	muscle contraction
0.74	GO:0007015	actin filament organization

0.85	GO:0005523	tropomyosin binding
0.73	GO:0003779	actin binding

0.83

GO:0005865

striated muscle thin filament

tr|T1EGT0|T1EGT0_HELRO
Uncharacterized protein
Search

COQ6

0.77	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

0.75	GO:0006744	ubiquinone biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.34	GO:0006468	protein phosphorylation
0.32	GO:0006351	transcription, DNA-templated
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.75	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
0.73	GO:0071949	FAD binding
0.69	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
0.34	GO:0004672	protein kinase activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003677	DNA binding

0.70	GO:0031314	extrinsic component of mitochondrial inner membrane
0.57	GO:0005794	Golgi apparatus
0.55	GO:0042995	cell projection
0.32	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.75

EC:1.14.13

GO:0016709

tr|T1EGT1|T1EGT1_HELRO
Uncharacterized protein
Search

0.11

CCAP

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.49	GO:0007600	sensory perception
0.48	GO:0009593	detection of chemical stimulus
0.44	GO:1901652	response to peptide
0.43	GO:0032870	cellular response to hormone stimulus
0.40	GO:1901699	cellular response to nitrogen compound
0.39	GO:1901701	cellular response to oxygen-containing compound
0.37	GO:2000479	regulation of cAMP-dependent protein kinase activity
0.36	GO:0007610	behavior
0.36	GO:0045761	regulation of adenylate cyclase activity

0.72	GO:0004930	G-protein coupled receptor activity
0.59	GO:0016500	protein-hormone receptor activity
0.52	GO:0001653	peptide receptor activity
0.48	GO:0004984	olfactory receptor activity
0.43	GO:0042277	peptide binding
0.37	GO:0031628	opioid receptor binding
0.37	GO:0030594	neurotransmitter receptor activity
0.36	GO:0104005	hijacked molecular function
0.36	GO:0015026	coreceptor activity
0.34	GO:0004715	non-membrane spanning protein tyrosine kinase activity

0.44	GO:0005886	plasma membrane
0.35	GO:0005768	endosome
0.34	GO:0043005	neuron projection
0.34	GO:0015629	actin cytoskeleton
0.34	GO:0005829	cytosol
0.33	GO:0005634	nucleus
0.33	GO:0033179	proton-transporting V-type ATPase, V0 domain
0.30	GO:0016021	integral component of membrane

0.34

GO:0004715

tr|T1EGT2|T1EGT2_HELRO
Uncharacterized protein
Search

GCNT7

0.83	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

0.36	GO:0036438	maintenance of lens transparency
0.35	GO:0034116	positive regulation of heterotypic cell-cell adhesion
0.35	GO:0010718	positive regulation of epithelial to mesenchymal transition
0.35	GO:0010812	negative regulation of cell-substrate adhesion
0.35	GO:0051897	positive regulation of protein kinase B signaling
0.35	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.35	GO:0007179	transforming growth factor beta receptor signaling pathway
0.35	GO:0030335	positive regulation of cell migration
0.34	GO:0006486	protein glycosylation
0.34	GO:0010608	posttranscriptional regulation of gene expression

0.77	GO:0008375	acetylglucosaminyltransferase activity
0.37	GO:0140103	catalytic activity, acting on a glycoprotein

0.34	GO:0005794	Golgi apparatus
0.30	GO:0016020	membrane

0.77

GO:0008375

tr|T1EGT3|T1EGT3_HELRO
Uncharacterized protein
Search

tr|T1EGT4|T1EGT4_HELRO
Uncharacterized protein
Search

ENPP4

0.49	Ectonucleotide pyrophosphatase/phosphodiesterase 4

0.51	GO:0030194	positive regulation of blood coagulation
0.43	GO:0046130	purine ribonucleoside catabolic process
0.37	GO:0006685	sphingomyelin catabolic process
0.36	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.34	GO:0006955	immune response
0.34	GO:0006898	receptor-mediated endocytosis

0.51	GO:0047710	bis(5'-adenosyl)-triphosphatase activity
0.41	GO:0035529	NADH pyrophosphatase activity
0.40	GO:0004528	phosphodiesterase I activity
0.36	GO:0004767	sphingomyelin phosphodiesterase activity
0.35	GO:0046872	metal ion binding
0.34	GO:0003676	nucleic acid binding
0.34	GO:0005044	scavenger receptor activity
0.34	GO:0001871	pattern binding
0.34	GO:0030246	carbohydrate binding
0.32	GO:0016740	transferase activity

0.37	GO:0070062	extracellular exosome
0.34	GO:0005773	vacuole
0.30	GO:0016020	membrane

0.51	EC:3.6.1.29	GO:0047710
0.51	KEGG:R00187	GO:0047710

tr|T1EGT5|T1EGT5_HELRO
Uncharacterized protein
Search

0.53	GO:0055114	oxidation-reduction process
0.50	GO:0042448	progesterone metabolic process
0.46	GO:0006704	glucocorticoid biosynthetic process
0.38	GO:0019373	epoxygenase P450 pathway
0.34	GO:0006702	androgen biosynthetic process
0.34	GO:0009410	response to xenobiotic stimulus
0.34	GO:0042572	retinol metabolic process
0.34	GO:0007548	sex differentiation
0.33	GO:0016125	sterol metabolic process
0.33	GO:0044550	secondary metabolite biosynthetic process

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.66	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.51	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity
0.33	GO:0019825	oxygen binding

0.43	GO:0043025	neuronal cell body
0.43	GO:0030424	axon
0.38	GO:0005739	mitochondrion
0.33	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.68

GO:0016705

tr|T1EGT6|T1EGT6_HELRO
Uncharacterized protein
Search

LMAN1

0.96	Mannose-binding endoplasmic reticulum-golgi intermediate compartment lectin

0.77	GO:0006888	ER to Golgi vesicle-mediated transport
0.52	GO:0007029	endoplasmic reticulum organization
0.51	GO:0007030	Golgi organization
0.49	GO:0010638	positive regulation of organelle organization
0.43	GO:0071391	cellular response to estrogen stimulus
0.36	GO:0034498	early endosome to Golgi transport
0.36	GO:0032527	protein exit from endoplasmic reticulum
0.34	GO:0006901	vesicle coating
0.34	GO:0018279	protein N-linked glycosylation via asparagine
0.34	GO:0048199	vesicle targeting, to, from or within Golgi

0.85	GO:0005537	mannose binding
0.34	GO:0043023	ribosomal large subunit binding
0.34	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding
0.34	GO:0043022	ribosome binding
0.33	GO:0003743	translation initiation factor activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0032561	guanyl ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.53	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.51	GO:0044220	host cell perinuclear region of cytoplasm
0.51	GO:0030017	sarcomere
0.50	GO:0030134	COPII-coated ER to Golgi transport vesicle
0.47	GO:0005794	Golgi apparatus
0.36	GO:0005789	endoplasmic reticulum membrane
0.36	GO:0098588	bounding membrane of organelle
0.36	GO:0070062	extracellular exosome
0.35	GO:0005730	nucleolus
0.34	GO:0030133	transport vesicle

tr|T1EGT7|T1EGT7_HELRO
Innexin
Search

0.40

Innexin

0.59

GO:0006811

ion transport

0.81	GO:0005921	gap junction
0.56	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1EGT8|T1EGT8_HELRO
Uncharacterized protein
Search

IRK-1

0.80	G-protein coupled inwardly rectifying potassium channel-B

0.78	GO:0034765	regulation of ion transmembrane transport
0.71	GO:0006813	potassium ion transport
0.61	GO:0098655	cation transmembrane transport
0.39	GO:0098660	inorganic ion transmembrane transport
0.37	GO:0098739	import across plasma membrane
0.35	GO:0046662	regulation of oviposition
0.35	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.34	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential
0.34	GO:0043330	response to exogenous dsRNA
0.34	GO:0032496	response to lipopolysaccharide

0.84	GO:0005242	inward rectifier potassium channel activity
0.34	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
0.34	GO:0005328	neurotransmitter:sodium symporter activity
0.32	GO:0005515	protein binding

0.41	GO:0005887	integral component of plasma membrane
0.35	GO:0034705	potassium channel complex
0.35	GO:0016323	basolateral plasma membrane
0.35	GO:0043025	neuronal cell body
0.34	GO:0043005	neuron projection
0.34	GO:0030016	myofibril

tr|T1EGT9|T1EGT9_HELRO
Uncharacterized protein
Search

0.55	G protein-coupled receptor

0.71

GO:0007186

G-protein coupled receptor signaling pathway

0.78

GO:0008528

G-protein coupled peptide receptor activity

0.30

GO:0044425

membrane part

tr|T1EGU0|T1EGU0_HELRO
Uncharacterized protein
Search

0.74	Potassium voltage-gated channel subfamily C member

0.73	GO:0071805	potassium ion transmembrane transport
0.73	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0051260	protein homooligomerization
0.34	GO:0030431	sleep
0.34	GO:0006379	mRNA cleavage
0.32	GO:0006351	transcription, DNA-templated

0.78	GO:0005249	voltage-gated potassium channel activity
0.35	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.33	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.33	GO:0046872	metal ion binding
0.32	GO:0003676	nucleic acid binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.34	GO:0032809	neuronal cell body membrane
0.34	GO:0032590	dendrite membrane
0.34	GO:0030673	axolemma

0.35

GO:0004114

tr|T1EGU1|T1EGU1_HELRO
Uncharacterized protein
Search

0.10	NAD kinase domain-containing protein 1 (Fragment)

0.78	GO:0006741	NADP biosynthetic process
0.68	GO:0019674	NAD metabolic process
0.57	GO:0016310	phosphorylation
0.32	GO:0006364	rRNA processing
0.32	GO:0032259	methylation

0.76	GO:0003951	NAD+ kinase activity
0.57	GO:0042803	protein homodimerization activity
0.45	GO:0032559	adenyl ribonucleotide binding
0.44	GO:0008144	drug binding
0.44	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0035299	inositol pentakisphosphate 2-kinase activity
0.35	GO:0042736	NADH kinase activity
0.34	GO:0046982	protein heterodimerization activity
0.33	GO:0003676	nucleic acid binding
0.32	GO:0008168	methyltransferase activity

0.48	GO:0005739	mitochondrion
0.34	GO:0000786	nucleosome
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.76	EC:2.7.1.23	GO:0003951
0.76	KEGG:R00104	GO:0003951

tr|T1EGU2|T1EGU2_HELRO
Uncharacterized protein
Search

0.63	Tyrosine kinase, non-receptor, 2 (Fragment)

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.49	GO:2000369	regulation of clathrin-dependent endocytosis
0.49	GO:0007165	signal transduction
0.47	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
0.42	GO:0046777	protein autophosphorylation
0.42	GO:0045087	innate immune response
0.42	GO:0016477	cell migration
0.41	GO:0042127	regulation of cell proliferation
0.40	GO:0030154	cell differentiation
0.35	GO:0006897	endocytosis

0.77	GO:0004713	protein tyrosine kinase activity
0.62	GO:0004712	protein serine/threonine/tyrosine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0005154	epidermal growth factor receptor binding
0.46	GO:0031625	ubiquitin protein ligase binding
0.44	GO:0042802	identical protein binding
0.37	GO:0050699	WW domain binding
0.35	GO:0004674	protein serine/threonine kinase activity

0.50	GO:0070436	Grb2-EGFR complex
0.46	GO:0005905	clathrin-coated pit
0.46	GO:0030136	clathrin-coated vesicle
0.42	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.40	GO:0005634	nucleus
0.36	GO:0005912	adherens junction
0.36	GO:0030659	cytoplasmic vesicle membrane
0.36	GO:0005768	endosome
0.36	GO:0030426	growth cone
0.35	GO:0043025	neuronal cell body

0.77

GO:0004713

tr|T1EGU3|T1EGU3_HELRO
Uncharacterized protein
Search

0.72	ATP-sensitive inward rectifier potassium channel

0.78	GO:0034765	regulation of ion transmembrane transport
0.71	GO:0006813	potassium ion transport
0.61	GO:0098655	cation transmembrane transport
0.46	GO:0090099	negative regulation of decapentaplegic signaling pathway
0.44	GO:0035220	wing disc development
0.42	GO:0042391	regulation of membrane potential
0.36	GO:0098660	inorganic ion transmembrane transport
0.33	GO:0006468	protein phosphorylation

0.84	GO:0005242	inward rectifier potassium channel activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.37	GO:0005887	integral component of plasma membrane
0.33	GO:0005840	ribosome

tr|T1EGU4|T1EGU4_HELRO
Uncharacterized protein
Search

0.75	Orphan G-protein coupled receptor 4

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.44	GO:0071310	cellular response to organic substance
0.43	GO:0009725	response to hormone
0.43	GO:0071495	cellular response to endogenous stimulus
0.39	GO:0034097	response to cytokine
0.38	GO:0007166	cell surface receptor signaling pathway
0.38	GO:0006935	chemotaxis
0.38	GO:0090026	positive regulation of monocyte chemotaxis
0.38	GO:0006954	inflammatory response
0.37	GO:0002376	immune system process

0.72	GO:0004930	G-protein coupled receptor activity
0.67	GO:0001653	peptide receptor activity
0.39	GO:0004896	cytokine receptor activity
0.38	GO:0019956	chemokine binding
0.36	GO:0005044	scavenger receptor activity
0.35	GO:0042277	peptide binding
0.34	GO:0004435	phosphatidylinositol phospholipase C activity
0.33	GO:0004875	complement receptor activity
0.33	GO:0042562	hormone binding
0.33	GO:0031628	opioid receptor binding

0.44	GO:0005887	integral component of plasma membrane
0.40	GO:0009986	cell surface
0.34	GO:0043025	neuronal cell body
0.34	GO:0043231	intracellular membrane-bounded organelle
0.34	GO:0098552	side of membrane
0.33	GO:0005737	cytoplasm

0.34	EC:3.1.4.11	GO:0004435
0.34	KEGG:R03435	GO:0004435

tr|T1EGU5|T1EGU5_HELRO
Uncharacterized protein
Search

CALR

0.77	Calreticulin

0.69	GO:0006457	protein folding
0.50	GO:0002502	peptide antigen assembly with MHC class I protein complex
0.49	GO:1901164	negative regulation of trophoblast cell migration
0.49	GO:2000510	positive regulation of dendritic cell chemotaxis
0.49	GO:0048387	negative regulation of retinoic acid receptor signaling pathway
0.48	GO:0090398	cellular senescence
0.48	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
0.48	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway
0.48	GO:0071157	negative regulation of cell cycle arrest
0.48	GO:0050766	positive regulation of phagocytosis

0.71	GO:0051082	unfolded protein binding
0.70	GO:0005509	calcium ion binding
0.48	GO:0050681	androgen receptor binding
0.47	GO:0005178	integrin binding
0.45	GO:0031625	ubiquitin protein ligase binding
0.44	GO:0003729	mRNA binding
0.44	GO:0030246	carbohydrate binding
0.37	GO:0042562	hormone binding
0.36	GO:0042277	peptide binding
0.34	GO:0005506	iron ion binding

0.70	GO:0005783	endoplasmic reticulum
0.46	GO:0005844	polysome
0.46	GO:0009897	external side of plasma membrane
0.45	GO:0048471	perinuclear region of cytoplasm
0.44	GO:0005635	nuclear envelope
0.44	GO:0005615	extracellular space
0.43	GO:0070013	intracellular organelle lumen
0.43	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.42	GO:0005829	cytosol
0.42	GO:0031984	organelle subcompartment

0.32

GO:0016740

tr|T1EGU6|T1EGU6_HELRO
Uncharacterized protein
Search

0.59	Potassium sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

0.67	GO:0071805	potassium ion transmembrane transport
0.56	GO:0034765	regulation of ion transmembrane transport
0.52	GO:0002027	regulation of heart rate
0.48	GO:0086046	membrane depolarization during SA node cell action potential
0.47	GO:0006814	sodium ion transport
0.47	GO:0098909	regulation of cardiac muscle cell action potential involved in regulation of contraction
0.47	GO:0071321	cellular response to cGMP
0.46	GO:0071320	cellular response to cAMP
0.46	GO:0003254	regulation of membrane depolarization
0.45	GO:0098659	inorganic cation import across plasma membrane

0.71	GO:0005249	voltage-gated potassium channel activity
0.52	GO:0030552	cAMP binding
0.48	GO:0005222	intracellular cAMP activated cation channel activity
0.45	GO:0005248	voltage-gated sodium channel activity
0.42	GO:0042802	identical protein binding
0.35	GO:0004692	cGMP-dependent protein kinase activity

0.47	GO:0098855	HCN channel complex
0.44	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0043195	terminal bouton
0.34	GO:0016323	basolateral plasma membrane
0.34	GO:0043025	neuronal cell body

0.35

EC:2.7.11.12

GO:0004692

tr|T1EGU7|T1EGU7_HELRO
Uncharacterized protein
Search

tr|T1EGU8|T1EGU8_HELRO
Uncharacterized protein
Search

0.61	Potassium voltage-gated channel protein Shaker

0.74	GO:0051260	protein homooligomerization
0.74	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.39	GO:0035235	ionotropic glutamate receptor signaling pathway
0.33	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
0.32	GO:0035556	intracellular signal transduction
0.32	GO:0016310	phosphorylation

0.77	GO:0005249	voltage-gated potassium channel activity
0.39	GO:0004970	ionotropic glutamate receptor activity
0.33	GO:0004143	diacylglycerol kinase activity
0.33	GO:0003951	NAD+ kinase activity
0.32	GO:0005509	calcium ion binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.32	GO:0005578	proteinaceous extracellular matrix
0.31	GO:0005622	intracellular

0.33	EC:2.7.1.107	GO:0004143
0.33	KEGG:R00104	GO:0003951

tr|T1EGU9|T1EGU9_HELRO
Uncharacterized protein
Search

0.74	Inward rectifier potassium channel

0.78	GO:0034765	regulation of ion transmembrane transport
0.71	GO:0006813	potassium ion transport
0.61	GO:0098655	cation transmembrane transport
0.49	GO:0099587	inorganic ion import across plasma membrane
0.38	GO:0051602	response to electrical stimulus
0.34	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential
0.34	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential
0.34	GO:0086091	regulation of heart rate by cardiac conduction

0.84	GO:0005242	inward rectifier potassium channel activity
0.35	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
0.34	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
0.34	GO:0005515	protein binding

0.46	GO:0008076	voltage-gated potassium channel complex
0.38	GO:0030315	T-tubule
0.37	GO:0009897	external side of plasma membrane

tr|T1EGV0|T1EGV0_HELRO
Uncharacterized protein
Search

IST1

0.74	Increased sodium tolerance 1 homolog

0.65	GO:0015031	protein transport
0.52	GO:0046745	viral capsid secondary envelopment
0.50	GO:0009838	abscission
0.50	GO:0048672	positive regulation of collateral sprouting
0.47	GO:0061640	cytoskeleton-dependent cytokinesis
0.46	GO:0045862	positive regulation of proteolysis
0.44	GO:0019076	viral release from host cell
0.41	GO:0007032	endosome organization
0.41	GO:0048675	axon extension
0.38	GO:0032509	endosome transport via multivesicular body sorting pathway

0.51	GO:0090541	MIT domain binding
0.47	GO:0045296	cadherin binding
0.45	GO:0032403	protein complex binding
0.35	GO:0042802	identical protein binding
0.33	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
0.33	GO:0030246	carbohydrate binding
0.33	GO:0008234	cysteine-type peptidase activity

0.49	GO:0090543	Flemming body
0.48	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.46	GO:0005813	centrosome
0.44	GO:0000785	chromatin
0.43	GO:0005829	cytosol
0.39	GO:0031410	cytoplasmic vesicle
0.38	GO:0012505	endomembrane system
0.36	GO:0070062	extracellular exosome
0.35	GO:0044428	nuclear part
0.35	GO:0031967	organelle envelope

0.33

EC:1.13.11

GO:0016702

tr|T1EGV1|T1EGV1_HELRO
Uncharacterized protein
Search

B4GALT4

0.80	N-acetyllactosaminide 3-alpha-galactosyltransferase

0.60	GO:0005975	carbohydrate metabolic process
0.35	GO:0048570	notochord morphogenesis
0.35	GO:0042074	cell migration involved in gastrulation
0.35	GO:0006364	rRNA processing
0.35	GO:0043413	macromolecule glycosylation
0.35	GO:0009101	glycoprotein biosynthetic process
0.34	GO:0032259	methylation
0.34	GO:0018146	keratan sulfate biosynthetic process
0.33	GO:0006464	cellular protein modification process
0.33	GO:0042128	nitrate assimilation

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.35	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
0.34	GO:0003723	RNA binding
0.33	GO:0030151	molybdenum ion binding
0.32	GO:0020037	heme binding
0.32	GO:0016491	oxidoreductase activity

0.43	GO:0005794	Golgi apparatus
0.34	GO:0098588	bounding membrane of organelle
0.34	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.65

GO:0016757

tr|T1EGV2|T1EGV2_HELRO
Uncharacterized protein
Search

0.70	GO:0042051	compound eye photoreceptor development
0.49	GO:0032259	methylation

0.49	GO:0008168	methyltransferase activity
0.44	GO:0046872	metal ion binding

0.52	GO:0005634	nucleus
0.43	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.49

GO:0008168

tr|T1EGV3|T1EGV3_HELRO
Uncharacterized protein
Search

KCNA7

0.70	Potassium voltage-gated channel subfamily A member 1

0.75	GO:0051260	protein homooligomerization
0.74	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.37	GO:0086052	membrane repolarization during SA node cell action potential
0.37	GO:0086050	membrane repolarization during bundle of His cell action potential
0.37	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential
0.36	GO:0060081	membrane hyperpolarization
0.36	GO:0086091	regulation of heart rate by cardiac conduction
0.36	GO:0043266	regulation of potassium ion transport
0.35	GO:0019229	regulation of vasoconstriction

0.78	GO:0005249	voltage-gated potassium channel activity
0.36	GO:0051393	alpha-actinin binding
0.36	GO:0097110	scaffold protein binding
0.36	GO:0019870	potassium channel inhibitor activity
0.35	GO:0019901	protein kinase binding
0.34	GO:0030955	potassium ion binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.36	GO:0014704	intercalated disc
0.35	GO:0045121	membrane raft

tr|T1EGV4|T1EGV4_HELRO
Uncharacterized protein
Search

0.67	sex peptide receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.53	GO:0048042	regulation of post-mating oviposition
0.53	GO:0045434	negative regulation of female receptivity, post-mating

0.75

GO:0008528

G-protein coupled peptide receptor activity

0.39	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

tr|T1EGV5|T1EGV5_HELRO
Uncharacterized protein
Search

0.51	B-type allatostatin receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.51	GO:0048042	regulation of post-mating oviposition
0.51	GO:0045434	negative regulation of female receptivity, post-mating

0.78

GO:0008528

G-protein coupled peptide receptor activity

0.39	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

tr|T1EGV6|T1EGV6_HELRO
Uncharacterized protein
Search

FAM46C

0.95	BMA-PQN-44

0.48	GO:0030193	regulation of blood coagulation
0.46	GO:0016539	intein-mediated protein splicing
0.39	GO:0007165	signal transduction
0.39	GO:0034220	ion transmembrane transport
0.39	GO:0060255	regulation of macromolecule metabolic process

0.48	GO:0016779	nucleotidyltransferase activity
0.43	GO:0003723	RNA binding
0.43	GO:0005230	extracellular ligand-gated ion channel activity
0.42	GO:0004888	transmembrane signaling receptor activity
0.41	GO:0005515	protein binding

0.43	GO:0005654	nucleoplasm
0.43	GO:0005829	cytosol
0.38	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.48

EC:2.7.7

GO:0016779

tr|T1EGV7|T1EGV7_HELRO
Uncharacterized protein
Search

0.54	M-phase inducer phosphatase

0.84	GO:1902751	positive regulation of cell cycle G2/M phase transition
0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.48	GO:0009794	regulation of mitotic cell cycle, embryonic
0.45	GO:0044839	cell cycle G2/M phase transition
0.45	GO:0010256	endomembrane system organization
0.44	GO:0060305	regulation of cell diameter
0.44	GO:0007488	histoblast morphogenesis
0.44	GO:0044772	mitotic cell cycle phase transition
0.43	GO:0045792	negative regulation of cell size
0.43	GO:0040019	positive regulation of embryonic development

0.75	GO:0004725	protein tyrosine phosphatase activity
0.38	GO:0050699	WW domain binding
0.37	GO:0019901	protein kinase binding
0.35	GO:0008138	protein tyrosine/serine/threonine phosphatase activity

0.45	GO:0005622	intracellular
0.39	GO:0043227	membrane-bounded organelle
0.39	GO:0043228	non-membrane-bounded organelle
0.37	GO:0044422	organelle part
0.35	GO:0031974	membrane-enclosed lumen
0.30	GO:0031224	intrinsic component of membrane

0.75

GO:0004725

tr|T1EGV8|T1EGV8_HELRO
Uncharacterized protein
Search

0.57	NLI interacting factor

0.68

GO:0016311

dephosphorylation

0.69

GO:0016791

phosphatase activity

0.69

EC:3.1.3 EC:3.1.3.41

GO:0016791

tr|T1EGV9|T1EGV9_HELRO
Uncharacterized protein
Search

0.72	GO:0045165	cell fate commitment
0.70	GO:0009792	embryo development ending in birth or egg hatching

0.41

GO:0005634

nucleus

tr|T1EGW0|T1EGW0_HELRO
Uncharacterized protein
Search

0.18	Solute carrier family 35 member D3

0.50	GO:0005794	Golgi apparatus
0.30	GO:0044425	membrane part

tr|T1EGW1|T1EGW1_HELRO
Uncharacterized protein
Search

SGPP1

0.84	Sphingosine-1-phosphate phosphatase 1

0.55	GO:0006668	sphinganine-1-phosphate metabolic process
0.54	GO:0006670	sphingosine metabolic process
0.51	GO:0097191	extrinsic apoptotic signaling pathway
0.50	GO:0097193	intrinsic apoptotic signaling pathway
0.45	GO:0016311	dephosphorylation
0.34	GO:0030148	sphingolipid biosynthetic process

0.55	GO:0042392	sphingosine-1-phosphate phosphatase activity
0.36	GO:0070780	dihydrosphingosine-1-phosphate phosphatase activity

0.46	GO:0005783	endoplasmic reticulum
0.45	GO:0005654	nucleoplasm
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.35	GO:0031984	organelle subcompartment
0.35	GO:0015629	actin cytoskeleton
0.35	GO:0005794	Golgi apparatus
0.34	GO:0005886	plasma membrane
0.34	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

tr|T1EGW2|T1EGW2_HELRO
Uncharacterized protein
Search

tr|T1EGW3|T1EGW3_HELRO
Uncharacterized protein
Search

0.43	Small GTPase

0.75	GO:0007264	small GTPase mediated signal transduction
0.43	GO:0071896	protein localization to adherens junction
0.43	GO:0055113	epiboly involved in gastrulation with mouth forming second
0.37	GO:0051301	cell division
0.36	GO:0033043	regulation of organelle organization
0.36	GO:0007163	establishment or maintenance of cell polarity
0.36	GO:0051050	positive regulation of transport
0.36	GO:0019953	sexual reproduction
0.36	GO:0031384	regulation of initiation of mating projection growth
0.36	GO:0048522	positive regulation of cellular process

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0004767	sphingomyelin phosphodiesterase activity
0.33	GO:0005515	protein binding

0.45	GO:0005622	intracellular
0.35	GO:0120025	plasma membrane bounded cell projection
0.35	GO:0005934	cellular bud tip
0.35	GO:0005935	cellular bud neck
0.34	GO:0005886	plasma membrane
0.34	GO:0098805	whole membrane
0.34	GO:0098588	bounding membrane of organelle
0.34	GO:0044463	cell projection part
0.34	GO:0031982	vesicle
0.34	GO:0012505	endomembrane system

0.37	EC:3.1.4.12	GO:0004767
0.37	KEGG:R02541	GO:0004767

tr|T1EGW4|T1EGW4_HELRO
Uncharacterized protein
Search

0.38	GO:0097264	self proteolysis
0.34	GO:0006468	protein phosphorylation

0.34	GO:0004672	protein kinase activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.36	GO:0005643	nuclear pore
0.30	GO:0031224	intrinsic component of membrane

tr|T1EGW5|T1EGW5_HELRO
Uncharacterized protein
Search

ARID3B

0.73	AT-rich interactive domain-containing protein 3A-like protein

0.39	GO:0006366	transcription by RNA polymerase II
0.39	GO:0045944	positive regulation of transcription by RNA polymerase II
0.34	GO:0007275	multicellular organism development

0.53	GO:0003677	DNA binding
0.40	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.40	GO:0001067	regulatory region nucleic acid binding
0.39	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.38	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.33	GO:0005515	protein binding

0.59	GO:0005634	nucleus
0.36	GO:0043233	organelle lumen
0.35	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

tr|T1EGW6|T1EGW6_HELRO
Uncharacterized protein
Search

0.10	Inositol 1,4,5-trisphosphate receptor type 1 (Fragment)

0.82	GO:0048016	inositol phosphate-mediated signaling
0.75	GO:0070588	calcium ion transmembrane transport
0.56	GO:0051283	negative regulation of sequestering of calcium ion
0.56	GO:0060402	calcium ion transport into cytosol
0.49	GO:0050917	sensory perception of umami taste
0.49	GO:0071361	cellular response to ethanol
0.49	GO:0050916	sensory perception of sweet taste
0.48	GO:0071320	cellular response to cAMP
0.48	GO:0001666	response to hypoxia
0.48	GO:0050913	sensory perception of bitter taste

0.83	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
0.82	GO:0070679	inositol 1,4,5 trisphosphate binding
0.51	GO:0035091	phosphatidylinositol binding
0.49	GO:0097110	scaffold protein binding
0.43	GO:0005509	calcium ion binding
0.37	GO:0019855	calcium channel inhibitor activity
0.36	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding
0.36	GO:0000822	inositol hexakisphosphate binding
0.33	GO:0051287	NAD binding
0.33	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

0.67	GO:0005783	endoplasmic reticulum
0.52	GO:0043235	receptor complex
0.50	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.49	GO:0016528	sarcoplasm
0.48	GO:0031984	organelle subcompartment
0.45	GO:0098588	bounding membrane of organelle
0.44	GO:0005730	nucleolus
0.44	GO:0005938	cell cortex
0.43	GO:0005654	nucleoplasm
0.42	GO:0005886	plasma membrane

0.33

EC:1.1.1

GO:0016616

tr|T1EGW7|T1EGW7_HELRO
Uncharacterized protein
Search

0.63

GO:0006468

protein phosphorylation

0.63	GO:0004672	protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

tr|T1EGW8|T1EGW8_HELRO
Uncharacterized protein
Search

0.10	Large neutral amino acids transporter small subunit 1 (Fragment)

0.65	GO:0006865	amino acid transport
0.55	GO:0055085	transmembrane transport
0.44	GO:0007399	nervous system development
0.43	GO:0030154	cell differentiation
0.39	GO:0050900	leukocyte migration
0.35	GO:0006812	cation transport
0.35	GO:0006520	cellular amino acid metabolic process

0.57	GO:0022857	transmembrane transporter activity
0.46	GO:0042605	peptide antigen binding
0.35	GO:0005515	protein binding

0.48	GO:0005829	cytosol
0.46	GO:0016324	apical plasma membrane
0.42	GO:0005887	integral component of plasma membrane
0.42	GO:0043231	intracellular membrane-bounded organelle
0.41	GO:0070062	extracellular exosome

tr|T1EGW9|T1EGW9_HELRO
Uncharacterized protein
Search

0.38	Zinc carboxypeptidase

0.61	GO:0006508	proteolysis
0.33	GO:0006030	chitin metabolic process
0.33	GO:0006836	neurotransmitter transport
0.32	GO:0055085	transmembrane transport

0.78	GO:0004181	metallocarboxypeptidase activity
0.63	GO:0008270	zinc ion binding
0.34	GO:0004252	serine-type endopeptidase activity
0.34	GO:0000062	fatty-acyl-CoA binding
0.33	GO:0008061	chitin binding
0.33	GO:0005328	neurotransmitter:sodium symporter activity
0.33	GO:0005509	calcium ion binding

0.37	GO:0046658	anchored component of plasma membrane
0.37	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane

0.78

EC:3.4.17

GO:0004181

tr|T1EGX0|T1EGX0_HELRO
Uncharacterized protein
Search

tr|T1EGX1|T1EGX1_HELRO
Uncharacterized protein
Search

0.66	Alkylated DNA repair protein alkB

0.64	GO:0006281	DNA repair
0.53	GO:0055114	oxidation-reduction process
0.39	GO:0032259	methylation
0.38	GO:0080111	DNA demethylation
0.37	GO:0042245	RNA repair
0.35	GO:0055085	transmembrane transport
0.34	GO:0006370	7-methylguanosine mRNA capping
0.34	GO:0035335	peptidyl-tyrosine dephosphorylation
0.33	GO:0006508	proteolysis

0.52	GO:0016491	oxidoreductase activity
0.39	GO:0008168	methyltransferase activity
0.37	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.37	GO:0008198	ferrous iron binding
0.34	GO:0004484	mRNA guanylyltransferase activity
0.34	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.34	GO:0004725	protein tyrosine phosphatase activity
0.34	GO:0004222	metalloendopeptidase activity
0.33	GO:0016746	transferase activity, transferring acyl groups
0.32	GO:0003677	DNA binding

0.38	GO:0005719	nuclear euchromatin
0.35	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

0.52

GO:0016491

tr|T1EGX2|T1EGX2_HELRO
Uncharacterized protein
Search

FUCTA

0.66	glycoprotein 3-alpha-L-fucosyltransferase A

0.81	GO:0036065	fucosylation
0.74	GO:0006486	protein glycosylation
0.45	GO:0007399	nervous system development
0.32	GO:0006468	protein phosphorylation

0.81	GO:0008417	fucosyltransferase activity
0.54	GO:0033932	1,3-alpha-L-fucosidase activity
0.50	GO:0140103	catalytic activity, acting on a glycoprotein
0.32	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.81	GO:0032580	Golgi cisterna membrane
0.50	GO:0005797	Golgi medial cisterna
0.30	GO:0031224	intrinsic component of membrane

0.81

GO:0008417

tr|T1EGX3|T1EGX3_HELRO
Uncharacterized protein
Search

0.42	Two pore potassium channel protein sup-9

0.73	GO:0071805	potassium ion transmembrane transport
0.39	GO:0006937	regulation of muscle contraction
0.39	GO:0030322	stabilization of membrane potential
0.39	GO:0010469	regulation of receptor activity
0.38	GO:0060047	heart contraction
0.35	GO:0060964	regulation of gene silencing by miRNA
0.34	GO:0006879	cellular iron ion homeostasis
0.33	GO:0007017	microtubule-based process
0.33	GO:0007010	cytoskeleton organization

0.76	GO:0005267	potassium channel activity
0.40	GO:0046982	protein heterodimerization activity
0.39	GO:0022840	leak channel activity
0.39	GO:0008083	growth factor activity
0.38	GO:0022843	voltage-gated cation channel activity
0.34	GO:0044548	S100 protein binding
0.34	GO:0005200	structural constituent of cytoskeleton
0.34	GO:0008199	ferric iron binding
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding

0.40	GO:0036195	muscle cell projection membrane
0.40	GO:0055120	striated muscle dense body
0.38	GO:0005615	extracellular space
0.37	GO:0005887	integral component of plasma membrane
0.33	GO:0005874	microtubule

tr|T1EGX4|T1EGX4_HELRO
Uncharacterized protein
Search

PCMTD2

0.62	protein-L-isoaspartate O-methyltransferase domain-containing protein 2

0.73	GO:0008213	protein alkylation
0.67	GO:0043414	macromolecule methylation
0.33	GO:0035556	intracellular signal transduction

0.79	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
0.33	GO:0005515	protein binding

0.36	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:2.1.1.77

GO:0004719

tr|T1EGX5|T1EGX5_HELRO
Uncharacterized protein
Search

tr|T1EGX6|T1EGX6_HELRO
Uncharacterized protein
Search

tr|T1EGX7|T1EGX7_HELRO
Uncharacterized protein
Search

0.43	GO:0071711	basement membrane organization
0.42	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
0.42	GO:0007528	neuromuscular junction development
0.42	GO:0061304	retinal blood vessel morphogenesis
0.41	GO:0001569	branching involved in blood vessel morphogenesis
0.40	GO:0061333	renal tubule morphogenesis
0.40	GO:0071230	cellular response to amino acid stimulus
0.40	GO:0007399	nervous system development
0.39	GO:0060322	head development
0.38	GO:0048589	developmental growth

0.55	GO:0005201	extracellular matrix structural constituent
0.41	GO:0048407	platelet-derived growth factor binding
0.39	GO:0042302	structural constituent of cuticle
0.38	GO:0005518	collagen binding
0.34	GO:0004672	protein kinase activity
0.34	GO:0046872	metal ion binding
0.34	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor
0.34	GO:0038023	signaling receptor activity
0.34	GO:0016788	hydrolase activity, acting on ester bonds
0.34	GO:0003723	RNA binding

0.69	GO:0005581	collagen trimer
0.54	GO:0044420	extracellular matrix component
0.51	GO:0005578	proteinaceous extracellular matrix
0.40	GO:0099081	supramolecular polymer
0.38	GO:0005615	extracellular space
0.37	GO:0031594	neuromuscular junction
0.36	GO:0005618	cell wall
0.35	GO:0030056	hemidesmosome
0.34	GO:0036338	viral membrane
0.33	GO:0019867	outer membrane

0.34

GO:0016775

tr|T1EGX8|T1EGX8_HELRO
Uncharacterized protein
Search

ZCCHC24

0.89	Zinc finger CCHC domain-containing protein 24

0.34

GO:0010469

regulation of receptor activity

0.61	GO:0008270	zinc ion binding
0.50	GO:0003676	nucleic acid binding
0.34	GO:0008083	growth factor activity

0.33	GO:0005576	extracellular region
0.30	GO:0044425	membrane part

tr|T1EGX9|T1EGX9_HELRO
Uncharacterized protein
Search

tr|T1EGY0|T1EGY0_HELRO
Uncharacterized protein
Search

SKOR2

0.76	SKI family transcriptional corepressor 2

0.79	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
0.78	GO:0090288	negative regulation of cellular response to growth factor stimulus
0.70	GO:0030510	regulation of BMP signaling pathway
0.67	GO:1903507	negative regulation of nucleic acid-templated transcription
0.66	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
0.50	GO:0030182	neuron differentiation
0.49	GO:0045595	regulation of cell differentiation
0.49	GO:0048468	cell development
0.47	GO:0021936	regulation of cerebellar granule cell precursor proliferation
0.47	GO:0051093	negative regulation of developmental process

0.85	GO:0046332	SMAD binding
0.76	GO:0003714	transcription corepressor activity
0.46	GO:0042826	histone deacetylase binding
0.43	GO:0003682	chromatin binding
0.36	GO:0003677	DNA binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.51	GO:0005634	nucleus
0.42	GO:0005737	cytoplasm
0.42	GO:0043025	neuronal cell body
0.42	GO:0030425	dendrite
0.40	GO:0005667	transcription factor complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1EGY1|T1EGY1_HELRO
Uncharacterized protein
Search

tr|T1EGY2|T1EGY2_HELRO
Hexosyltransferase
Search

0.44	Hexosyltransferase

0.74

GO:0006486

protein glycosylation

0.81

GO:0008378

galactosyltransferase activity

0.74	GO:0000139	Golgi membrane
0.30	GO:0031224	intrinsic component of membrane

0.81

GO:0008378

tr|T1EGY3|T1EGY3_HELRO
Uncharacterized protein
Search

0.66	Solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein), member 17

0.52	GO:0035352	NAD transmembrane transport
0.52	GO:0080121	AMP transport
0.51	GO:0035350	FAD transmembrane transport
0.51	GO:0071106	adenosine 3',5'-bisphosphate transmembrane transport
0.51	GO:0015880	coenzyme A transport
0.49	GO:0015866	ADP transport
0.49	GO:0015867	ATP transport
0.45	GO:0006839	mitochondrial transport
0.43	GO:0015908	fatty acid transport
0.43	GO:0015858	nucleoside transport

0.52	GO:0044610	FMN transmembrane transporter activity
0.52	GO:0051724	NAD transmembrane transporter activity
0.52	GO:0080122	AMP transmembrane transporter activity
0.51	GO:0015230	FAD transmembrane transporter activity
0.51	GO:0071077	adenosine 3',5'-bisphosphate transmembrane transporter activity
0.49	GO:0015217	ADP transmembrane transporter activity
0.49	GO:0005347	ATP transmembrane transporter activity
0.42	GO:0051087	chaperone binding
0.32	GO:0016779	nucleotidyltransferase activity

0.48	GO:0005779	integral component of peroxisomal membrane
0.42	GO:0005739	mitochondrion
0.40	GO:0031967	organelle envelope

0.32

EC:2.7.7

GO:0016779

tr|T1EGY4|T1EGY4_HELRO
Uncharacterized protein
Search

0.47	GO:0050808	synapse organization
0.44	GO:0048488	synaptic vesicle endocytosis
0.42	GO:0050804	modulation of chemical synaptic transmission
0.42	GO:0007155	cell adhesion
0.38	GO:0071709	membrane assembly
0.38	GO:0007399	nervous system development
0.35	GO:1902474	positive regulation of protein localization to synapse
0.34	GO:0032024	positive regulation of insulin secretion
0.33	GO:0006629	lipid metabolic process
0.33	GO:0072330	monocarboxylic acid biosynthetic process

0.51	GO:0042043	neurexin family protein binding
0.48	GO:0016787	hydrolase activity
0.36	GO:0004872	receptor activity
0.33	GO:0003779	actin binding
0.32	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.32	GO:0003735	structural constituent of ribosome
0.32	GO:0020037	heme binding
0.32	GO:0005506	iron ion binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding

0.45	GO:0045202	synapse
0.40	GO:0005887	integral component of plasma membrane
0.38	GO:0009986	cell surface
0.32	GO:0005840	ribosome

0.48

GO:0016787

tr|T1EGY5|T1EGY5_HELRO
Uncharacterized protein
Search

0.80	Post-GPI attachment to proteins factor

0.39	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
0.39	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.38	GO:0042770	signal transduction in response to DNA damage
0.35	GO:0043043	peptide biosynthetic process
0.35	GO:0044267	cellular protein metabolic process
0.34	GO:0010467	gene expression
0.34	GO:0009059	macromolecule biosynthetic process

0.36

GO:0003735

structural constituent of ribosome

0.36	GO:0005840	ribosome
0.35	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EGY6|T1EGY6_HELRO
Hexosyltransferase
Search

0.24	Hexosyltransferase

0.74	GO:0006486	protein glycosylation
0.36	GO:0015991	ATP hydrolysis coupled proton transport

0.81	GO:0008378	galactosyltransferase activity
0.36	GO:0046961	proton-transporting ATPase activity, rotational mechanism
0.35	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism

0.74	GO:0000139	Golgi membrane
0.36	GO:0033180	proton-transporting V-type ATPase, V1 domain
0.30	GO:0031224	intrinsic component of membrane

0.81

GO:0008378

tr|T1EGY7|T1EGY7_HELRO
Uncharacterized protein
Search

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:0042472	inner ear morphogenesis
0.52	GO:0070172	positive regulation of tooth mineralization
0.51	GO:0060041	retina development in camera-type eye
0.50	GO:0071281	cellular response to iron ion
0.50	GO:2000378	negative regulation of reactive oxygen species metabolic process
0.50	GO:0030501	positive regulation of bone mineralization
0.50	GO:0060021	palate development

0.61	GO:0003700	DNA binding transcription factor activity
0.51	GO:0044212	transcription regulatory region DNA binding
0.49	GO:1990837	sequence-specific double-stranded DNA binding
0.47	GO:0003713	transcription coactivator activity
0.45	GO:0046983	protein dimerization activity
0.36	GO:0003682	chromatin binding
0.34	GO:0001106	RNA polymerase II transcription corepressor activity
0.34	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.33	GO:0042802	identical protein binding
0.33	GO:0008134	transcription factor binding

0.61	GO:0005634	nucleus
0.46	GO:0005813	centrosome
0.45	GO:0043233	organelle lumen
0.44	GO:0005794	Golgi apparatus
0.43	GO:0005829	cytosol
0.37	GO:0005739	mitochondrion
0.33	GO:0005840	ribosome

tr|T1EGY8|T1EGY8_HELRO
Uncharacterized protein
Search

0.10	Phd finger protein 12 (Fragment)

0.35	GO:0065007	biological regulation
0.35	GO:0023052	signaling
0.35	GO:0007154	cell communication
0.34	GO:0051716	cellular response to stimulus

0.53	GO:0046872	metal ion binding
0.38	GO:0042393	histone binding
0.38	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.38	GO:0003682	chromatin binding
0.37	GO:0003712	transcription cofactor activity
0.35	GO:0008080	N-acetyltransferase activity

0.40	GO:0070822	Sin3-type complex
0.30	GO:0031224	intrinsic component of membrane

0.35

GO:0008080

tr|T1EGY9|T1EGY9_HELRO
Uncharacterized protein
Search

0.48	Putative HAT, C-terminal dimerization domain-containing protein

0.51	GO:0006357	regulation of transcription by RNA polymerase II
0.50	GO:0007275	multicellular organism development

0.68	GO:0046983	protein dimerization activity
0.52	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.43	GO:0003677	DNA binding

0.50	GO:0005654	nucleoplasm
0.40	GO:0005737	cytoplasm

tr|T1EGZ0|T1EGZ0_HELRO
Uncharacterized protein
Search

0.49	Voltage-sensitive sodium channel alpha subunit (Fragment)

0.75	GO:0035725	sodium ion transmembrane transport
0.73	GO:0034765	regulation of ion transmembrane transport
0.49	GO:0019233	sensory perception of pain
0.44	GO:0019228	neuronal action potential
0.44	GO:0086010	membrane depolarization during action potential
0.39	GO:0051930	regulation of sensory perception of pain
0.34	GO:0001947	heart looping
0.34	GO:0008016	regulation of heart contraction
0.34	GO:0071805	potassium ion transmembrane transport

0.83	GO:0005248	voltage-gated sodium channel activity
0.70	GO:0022832	voltage-gated channel activity
0.68	GO:0022839	ion gated channel activity
0.68	GO:0008381	mechanosensitive ion channel activity
0.44	GO:0005509	calcium ion binding
0.35	GO:0008081	phosphoric diester hydrolase activity
0.34	GO:0005267	potassium channel activity
0.34	GO:0005515	protein binding

0.81	GO:0001518	voltage-gated sodium channel complex
0.40	GO:0044299	C-fiber
0.34	GO:0008076	voltage-gated potassium channel complex
0.34	GO:0070062	extracellular exosome

0.35

GO:0008081

tr|T1EGZ1|T1EGZ1_HELRO
Uncharacterized protein
Search

STUB1

0.87	E3 ubiquitin-protein ligase CHIP

0.73	GO:0016567	protein ubiquitination
0.47	GO:0017062	respiratory chain complex III assembly
0.47	GO:0097033	mitochondrial respiratory chain complex III biogenesis
0.46	GO:0033108	mitochondrial respiratory chain complex assembly
0.44	GO:0046627	negative regulation of insulin receptor signaling pathway
0.43	GO:0030579	ubiquitin-dependent SMAD protein catabolic process
0.43	GO:0031943	regulation of glucocorticoid metabolic process
0.43	GO:0030001	metal ion transport
0.42	GO:0090035	positive regulation of chaperone-mediated protein complex assembly
0.42	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process

0.73	GO:0004842	ubiquitin-protein transferase activity
0.44	GO:0061659	ubiquitin-like protein ligase activity
0.44	GO:0046873	metal ion transmembrane transporter activity
0.43	GO:0030911	TPR domain binding
0.43	GO:0016874	ligase activity
0.42	GO:0051879	Hsp90 protein binding
0.42	GO:0030544	Hsp70 protein binding
0.42	GO:0046332	SMAD binding
0.42	GO:0046983	protein dimerization activity
0.41	GO:0051787	misfolded protein binding

0.48	GO:0000813	ESCRT I complex
0.46	GO:0030018	Z disc
0.41	GO:0042405	nuclear inclusion body
0.40	GO:0005739	mitochondrion
0.39	GO:0000151	ubiquitin ligase complex
0.38	GO:0005783	endoplasmic reticulum
0.38	GO:0005654	nucleoplasm
0.38	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.43	EC:6	GO:0016874
0.73	KEGG:R03876	GO:0004842

tr|T1EGZ2|T1EGZ2_HELRO
Uncharacterized protein
Search

0.42	GO:0016310	phosphorylation
0.38	GO:0006464	cellular protein modification process

0.43	GO:0016301	kinase activity
0.38	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.37	GO:0140096	catalytic activity, acting on a protein
0.36	GO:0030554	adenyl nucleotide binding
0.36	GO:0097367	carbohydrate derivative binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding

0.30

GO:0031224

intrinsic component of membrane

0.38

GO:0016773

tr|T1EGZ3|T1EGZ3_HELRO
Uncharacterized protein
Search

0.53	GO:0007165	signal transduction
0.49	GO:0072659	protein localization to plasma membrane
0.47	GO:0006888	ER to Golgi vesicle-mediated transport
0.38	GO:0050790	regulation of catalytic activity
0.38	GO:2000031	regulation of salicylic acid mediated signaling pathway
0.37	GO:0071446	cellular response to salicylic acid stimulus
0.37	GO:0006468	protein phosphorylation
0.37	GO:0044093	positive regulation of molecular function
0.36	GO:0001933	negative regulation of protein phosphorylation
0.36	GO:0008643	carbohydrate transport

0.50	GO:0008093	cytoskeletal adaptor activity
0.50	GO:0051117	ATPase binding
0.50	GO:0030507	spectrin binding
0.43	GO:0003723	RNA binding
0.38	GO:0030234	enzyme regulator activity
0.37	GO:0008270	zinc ion binding
0.37	GO:0140096	catalytic activity, acting on a protein
0.37	GO:0005216	ion channel activity
0.36	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.36	GO:0008081	phosphoric diester hydrolase activity

0.52	GO:0014731	spectrin-associated cytoskeleton
0.39	GO:0005886	plasma membrane
0.37	GO:0005737	cytoplasm
0.35	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.36

GO:0016773

tr|T1EGZ4|T1EGZ4_HELRO
Elongation factor Ts, mitochondrial
Search

TSFM

0.71	Elongation factor Ts, mitochondrial

0.70	GO:0006414	translational elongation
0.41	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.41	GO:0032543	mitochondrial translation
0.40	GO:0070129	regulation of mitochondrial translation
0.34	GO:0042246	tissue regeneration
0.34	GO:0032784	regulation of DNA-templated transcription, elongation
0.33	GO:0007155	cell adhesion

0.71	GO:0003746	translation elongation factor activity
0.41	GO:0004521	endoribonuclease activity
0.33	GO:0005515	protein binding

0.56	GO:0005739	mitochondrion
0.38	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part
0.36	GO:0005634	nucleus
0.34	GO:0009536	plastid
0.30	GO:0016020	membrane

tr|T1EGZ5|T1EGZ5_HELRO
Uncharacterized protein
Search

TNNC2

0.81	Troponin C, skeletal muscle

0.59	GO:0003009	skeletal muscle contraction
0.49	GO:0006937	regulation of muscle contraction
0.38	GO:0006468	protein phosphorylation
0.38	GO:0030049	muscle filament sliding
0.36	GO:0009738	abscisic acid-activated signaling pathway
0.36	GO:0018209	peptidyl-serine modification
0.35	GO:0042554	superoxide anion generation
0.35	GO:1990823	response to leukemia inhibitory factor
0.34	GO:0055114	oxidation-reduction process
0.34	GO:0071345	cellular response to cytokine stimulus

0.70	GO:0005509	calcium ion binding
0.51	GO:0003779	actin binding
0.50	GO:0048306	calcium-dependent protein binding
0.46	GO:0032403	protein complex binding
0.38	GO:0004672	protein kinase activity
0.38	GO:0031014	troponin T binding
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005516	calmodulin binding

0.56	GO:0005861	troponin complex
0.35	GO:0005829	cytosol
0.34	GO:0070062	extracellular exosome
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.35

EC:1.6.3

GO:0016175

tr|T1EGZ6|T1EGZ6_HELRO
UDP-glucuronosyltransferase
Search

0.28	UDP-glucuronosyltransferase

0.36	GO:0016999	antibiotic metabolic process
0.33	GO:0022900	electron transport chain
0.33	GO:0030259	lipid glycosylation
0.32	GO:0005975	carbohydrate metabolic process

0.70	GO:0015020	glucuronosyltransferase activity
0.34	GO:0051537	2 iron, 2 sulfur cluster binding
0.33	GO:0050660	flavin adenine dinucleotide binding
0.33	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
0.33	GO:0009055	electron transfer activity
0.32	GO:0046872	metal ion binding

0.33	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0044425	membrane part

0.70

EC:2.4.1.17

GO:0015020

tr|T1EGZ7|T1EGZ7_HELRO
Uncharacterized protein
Search

SKIA

0.91	Sno oncogene (inferred by orthology to a D. melanogaster protein)

0.55	GO:0006351	transcription, DNA-templated
0.54	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.52	GO:0010626	negative regulation of Schwann cell proliferation
0.52	GO:0030514	negative regulation of BMP signaling pathway
0.51	GO:0032926	negative regulation of activin receptor signaling pathway
0.50	GO:0045668	negative regulation of osteoblast differentiation
0.50	GO:0070207	protein homotrimerization
0.50	GO:0043388	positive regulation of DNA binding
0.50	GO:0060395	SMAD protein signal transduction
0.49	GO:0000122	negative regulation of transcription by RNA polymerase II

0.85	GO:0046332	SMAD binding
0.50	GO:0070491	repressing transcription factor binding
0.48	GO:0003714	transcription corepressor activity
0.47	GO:0031625	ubiquitin protein ligase binding
0.47	GO:0019901	protein kinase binding
0.46	GO:0019904	protein domain specific binding
0.42	GO:0008270	zinc ion binding
0.40	GO:0046811	histone deacetylase inhibitor activity
0.36	GO:0003682	chromatin binding
0.36	GO:0042803	protein homodimerization activity

0.49	GO:0016605	PML body
0.46	GO:0005813	centrosome
0.40	GO:0043234	protein complex
0.38	GO:0017053	transcriptional repressor complex
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EGZ8|T1EGZ8_HELRO
Uncharacterized protein
Search

ADPRM

0.76	Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase

0.37	GO:0006468	protein phosphorylation
0.32	GO:0055114	oxidation-reduction process

0.51	GO:0016787	hydrolase activity
0.37	GO:0004672	protein kinase activity
0.35	GO:0030554	adenyl nucleotide binding
0.35	GO:0097367	carbohydrate derivative binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0046872	metal ion binding
0.32	GO:0020037	heme binding
0.32	GO:0016491	oxidoreductase activity

0.30

GO:0031224

intrinsic component of membrane

0.51

GO:0016787

tr|T1EGZ9|T1EGZ9_HELRO
Uncharacterized protein
Search

0.85	Sine oculis Homeobox like 1

0.59	GO:0008283	cell proliferation
0.59	GO:0048513	animal organ development
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0006915	apoptotic process
0.56	GO:0010468	regulation of gene expression
0.49	GO:0060788	ectodermal placode formation
0.49	GO:0016477	cell migration
0.48	GO:0090189	regulation of branching involved in ureteric bud morphogenesis
0.48	GO:0035270	endocrine system development

0.64	GO:0043565	sequence-specific DNA binding
0.50	GO:0003700	DNA binding transcription factor activity
0.44	GO:0008134	transcription factor binding
0.44	GO:0001012	RNA polymerase II regulatory region DNA binding
0.42	GO:0003690	double-stranded DNA binding
0.40	GO:0032403	protein complex binding
0.39	GO:0003682	chromatin binding

0.61	GO:0005634	nucleus
0.40	GO:0005667	transcription factor complex
0.38	GO:0070013	intracellular organelle lumen
0.36	GO:0043232	intracellular non-membrane-bounded organelle
0.36	GO:0044446	intracellular organelle part
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EH00|T1EH00_HELRO
Metalloendopeptidase
Search

0.41	Metalloendopeptidase

0.69	GO:0018996	molting cycle, collagen and cuticulin-based cuticle
0.60	GO:0006508	proteolysis
0.39	GO:0040002	collagen and cuticulin-based cuticle development
0.34	GO:0022404	molting cycle process
0.33	GO:0010951	negative regulation of endopeptidase activity
0.32	GO:0051716	cellular response to stimulus
0.32	GO:0034220	ion transmembrane transport
0.32	GO:0023052	signaling
0.32	GO:0007154	cell communication
0.32	GO:0006950	response to stress

0.69	GO:0004222	metalloendopeptidase activity
0.62	GO:0008270	zinc ion binding
0.35	GO:0005509	calcium ion binding
0.34	GO:0070492	oligosaccharide binding
0.33	GO:0004867	serine-type endopeptidase inhibitor activity
0.33	GO:0005230	extracellular ligand-gated ion channel activity
0.33	GO:0004888	transmembrane signaling receptor activity
0.31	GO:0016491	oxidoreductase activity

0.46	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0004222

tr|T1EH01|T1EH01_HELRO
Uncharacterized protein
Search

tr|T1EH02|T1EH02_HELRO
Uncharacterized protein
Search

0.62	G/T mismatch-specific thymine DNA glycosylase

0.65	GO:0006281	DNA repair
0.38	GO:1902544	regulation of DNA N-glycosylase activity
0.38	GO:0035562	negative regulation of chromatin binding
0.37	GO:0032091	negative regulation of protein binding
0.37	GO:0080111	DNA demethylation
0.36	GO:0040029	regulation of gene expression, epigenetic
0.36	GO:0000122	negative regulation of transcription by RNA polymerase II
0.36	GO:0009790	embryo development
0.33	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation

0.74	GO:0019104	DNA N-glycosylase activity
0.46	GO:0003677	DNA binding
0.37	GO:0031404	chloride ion binding
0.37	GO:0032183	SUMO binding
0.37	GO:0005080	protein kinase C binding
0.37	GO:0043621	protein self-association
0.36	GO:0031402	sodium ion binding
0.36	GO:0001104	RNA polymerase II transcription cofactor activity
0.36	GO:0042803	protein homodimerization activity
0.34	GO:0000287	magnesium ion binding

0.37	GO:0005634	nucleus
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part
0.33	GO:0005886	plasma membrane
0.33	GO:0072669	tRNA-splicing ligase complex
0.30	GO:0016021	integral component of membrane

0.74

EC:3.2.2

GO:0019104

tr|T1EH03|T1EH03_HELRO
Uncharacterized protein
Search

0.59	DnaJ like protein subfamily C member 17

0.62	GO:0034975	protein folding in endoplasmic reticulum
0.55	GO:0045454	cell redox homeostasis
0.50	GO:0030433	ubiquitin-dependent ERAD pathway
0.48	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
0.45	GO:0032781	positive regulation of ATPase activity
0.44	GO:0001933	negative regulation of protein phosphorylation
0.43	GO:0055114	oxidation-reduction process
0.39	GO:0009408	response to heat
0.37	GO:0065002	intracellular protein transmembrane transport
0.36	GO:0072594	establishment of protein localization to organelle

0.53	GO:0015036	disulfide oxidoreductase activity
0.50	GO:0051082	unfolded protein binding
0.48	GO:0030544	Hsp70 protein binding
0.48	GO:0051787	misfolded protein binding
0.48	GO:0051117	ATPase binding
0.47	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
0.45	GO:0001671	ATPase activator activity
0.45	GO:0051087	chaperone binding
0.37	GO:0008270	zinc ion binding
0.36	GO:0003676	nucleic acid binding

0.53	GO:0005783	endoplasmic reticulum
0.45	GO:0043233	organelle lumen
0.41	GO:0044446	intracellular organelle part
0.39	GO:0043234	protein complex
0.35	GO:0005829	cytosol
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.47

EC:1.8.4

GO:0016671

tr|T1EH04|T1EH04_HELRO
Uncharacterized protein
Search

RAB40C

0.57	SOCS box-containing protein RAR3 (Fragment)

0.61	GO:0035556	intracellular signal transduction
0.61	GO:0016567	protein ubiquitination
0.44	GO:0072659	protein localization to plasma membrane
0.44	GO:0017157	regulation of exocytosis
0.44	GO:0006904	vesicle docking involved in exocytosis
0.41	GO:0009306	protein secretion
0.35	GO:0001881	receptor recycling
0.34	GO:0042552	myelination
0.34	GO:0010951	negative regulation of endopeptidase activity

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0004867	serine-type endopeptidase inhibitor activity
0.33	GO:0005515	protein binding

0.45	GO:0030667	secretory granule membrane
0.44	GO:0008021	synaptic vesicle
0.42	GO:0005768	endosome
0.37	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0005886	plasma membrane
0.33	GO:0005576	extracellular region

tr|T1EH05|T1EH05_HELRO
Uncharacterized protein
Search

0.85	Suppressor of cytokine signaling (Fragment)

0.78	GO:0040008	regulation of growth
0.72	GO:0016567	protein ubiquitination
0.62	GO:0035556	intracellular signal transduction
0.51	GO:0046426	negative regulation of JAK-STAT cascade
0.48	GO:0050868	negative regulation of T cell activation
0.47	GO:0010498	proteasomal protein catabolic process
0.45	GO:0006469	negative regulation of protein kinase activity
0.45	GO:0019221	cytokine-mediated signaling pathway
0.38	GO:0051128	regulation of cellular component organization
0.36	GO:0001678	cellular glucose homeostasis

0.46	GO:0004860	protein kinase inhibitor activity
0.44	GO:0008269	JAK pathway signal transduction adaptor activity
0.43	GO:0005159	insulin-like growth factor receptor binding

0.51	GO:0001772	immunological synapse
0.45	GO:0005622	intracellular

tr|T1EH06|T1EH06_HELRO
Uncharacterized protein
Search

SCO1

0.95	Synthesis of cytochrome c oxidase

0.72	GO:0008535	respiratory chain complex IV assembly
0.71	GO:0006878	cellular copper ion homeostasis
0.67	GO:0006825	copper ion transport
0.57	GO:0045454	cell redox homeostasis
0.51	GO:1901799	negative regulation of proteasomal protein catabolic process
0.50	GO:0097034	mitochondrial respiratory chain complex IV biogenesis
0.49	GO:0033108	mitochondrial respiratory chain complex assembly
0.40	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
0.40	GO:0006367	transcription initiation from RNA polymerase II promoter
0.34	GO:0007018	microtubule-based movement

0.63	GO:0005507	copper ion binding
0.36	GO:0005515	protein binding
0.35	GO:0003677	DNA binding
0.34	GO:0003777	microtubule motor activity
0.34	GO:0044877	macromolecular complex binding
0.34	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.33	GO:0052689	carboxylic ester hydrolase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.55	GO:0072492	host cell mitochondrial intermembrane space
0.55	GO:0031966	mitochondrial membrane
0.55	GO:0019866	organelle inner membrane
0.49	GO:0030016	myofibril
0.36	GO:0005634	nucleus
0.34	GO:0043234	protein complex
0.34	GO:0015629	actin cytoskeleton
0.34	GO:0044430	cytoskeletal part
0.33	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.34	EC:2.7.7.6	GO:0003899
0.33	KEGG:R00630	GO:0052689

tr|T1EH07|T1EH07_HELRO
Uncharacterized protein
Search

0.44	GO:1903506	regulation of nucleic acid-templated transcription
0.44	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.44	GO:0010468	regulation of gene expression
0.36	GO:0045196	establishment or maintenance of neuroblast polarity
0.36	GO:0035167	larval lymph gland hemopoiesis
0.34	GO:1902679	negative regulation of RNA biosynthetic process
0.34	GO:0006915	apoptotic process
0.34	GO:0007186	G-protein coupled receptor signaling pathway
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.33	GO:0006351	transcription, DNA-templated

0.51	GO:0003676	nucleic acid binding
0.45	GO:0046872	metal ion binding
0.37	GO:0003700	DNA binding transcription factor activity
0.34	GO:0004930	G-protein coupled receptor activity

0.44	GO:0005634	nucleus
0.38	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part
0.34	GO:0048500	signal recognition particle
0.30	GO:0016020	membrane

tr|T1EH08|T1EH08_HELRO
Uncharacterized protein
Search

0.43	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.39	GO:0007089	traversing start control point of mitotic cell cycle
0.39	GO:0048478	replication fork protection
0.38	GO:0000076	DNA replication checkpoint
0.38	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
0.38	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
0.38	GO:0006368	transcription elongation from RNA polymerase II promoter

0.82	GO:0008190	eukaryotic initiation factor 4E binding
0.72	GO:0019904	protein domain specific binding
0.45	GO:0004527	exonuclease activity
0.43	GO:0004519	endonuclease activity
0.41	GO:0004540	ribonuclease activity
0.32	GO:0046872	metal ion binding

0.77	GO:0005801	cis-Golgi network
0.74	GO:0048471	perinuclear region of cytoplasm
0.66	GO:0005783	endoplasmic reticulum
0.64	GO:0005829	cytosol
0.58	GO:0005634	nucleus
0.38	GO:0030015	CCR4-NOT core complex
0.38	GO:0000932	P-body
0.37	GO:0000428	DNA-directed RNA polymerase complex
0.36	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part

tr|T1EH09|T1EH09_HELRO
Uncharacterized protein
Search

0.77	GO:0007264	small GTPase mediated signal transduction
0.66	GO:0065009	regulation of molecular function
0.61	GO:0042127	regulation of cell proliferation
0.36	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.35	GO:0018108	peptidyl-tyrosine phosphorylation
0.35	GO:2000670	positive regulation of dendritic cell apoptotic process
0.35	GO:0048022	negative regulation of melanin biosynthetic process
0.34	GO:0071321	cellular response to cGMP
0.34	GO:0038180	nerve growth factor signaling pathway
0.34	GO:2001214	positive regulation of vasculogenesis

0.75	GO:0005085	guanyl-nucleotide exchange factor activity
0.61	GO:0005096	GTPase activator activity
0.61	GO:0017016	Ras GTPase binding
0.35	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.35	GO:0031697	beta-1 adrenergic receptor binding
0.34	GO:0070300	phosphatidic acid binding
0.34	GO:0050699	WW domain binding
0.34	GO:0030165	PDZ domain binding
0.34	GO:0030552	cAMP binding
0.33	GO:0004003	ATP-dependent DNA helicase activity

0.45	GO:0005622	intracellular
0.34	GO:0016324	apical plasma membrane
0.34	GO:0043025	neuronal cell body
0.34	GO:0005923	bicellular tight junction
0.34	GO:0043005	neuron projection
0.33	GO:0045202	synapse
0.33	GO:0031982	vesicle
0.33	GO:0043234	protein complex
0.33	GO:0012505	endomembrane system
0.32	GO:0044422	organelle part

0.35

EC:2.7.10.1

GO:0004714

tr|T1EH10|T1EH10_HELRO
Tetraspanin
Search

0.40	Tetraspanin

0.40	GO:0007166	cell surface receptor signaling pathway
0.40	GO:0042338	cuticle development involved in collagen and cuticulin-based cuticle molting cycle
0.39	GO:0098773	skin epidermis development
0.36	GO:0046777	protein autophosphorylation
0.36	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

0.36	GO:0004712	protein serine/threonine/tyrosine kinase activity
0.36	GO:0004416	hydroxyacylglutathione hydrolase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.39

GO:0005887

integral component of plasma membrane

0.36

EC:2.7.12.1

GO:0004712

tr|T1EH11|T1EH11_HELRO
Uncharacterized protein
Search

tr|T1EH12|T1EH12_HELRO
Uncharacterized protein
Search

0.63	GO:0006468	protein phosphorylation
0.52	GO:0032147	activation of protein kinase activity
0.49	GO:0043406	positive regulation of MAP kinase activity
0.46	GO:0031098	stress-activated protein kinase signaling cascade
0.45	GO:0010311	lateral root formation
0.45	GO:0007112	male meiosis cytokinesis
0.44	GO:0007346	regulation of mitotic cell cycle
0.42	GO:0050850	positive regulation of calcium-mediated signaling
0.42	GO:0018212	peptidyl-tyrosine modification
0.41	GO:0042981	regulation of apoptotic process

0.64	GO:0004672	protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0004871	signal transducer activity
0.39	GO:0005078	MAP-kinase scaffold activity
0.38	GO:0004596	peptide alpha-N-acetyltransferase activity
0.34	GO:0043130	ubiquitin binding
0.33	GO:0003729	mRNA binding

0.45	GO:0009524	phragmoplast
0.42	GO:0000935	division septum
0.40	GO:1990315	Mcs4 RR-MAPKKK complex
0.39	GO:0031416	NatB complex
0.38	GO:0005934	cellular bud tip
0.38	GO:0005935	cellular bud neck
0.38	GO:0010494	cytoplasmic stress granule
0.37	GO:0005634	nucleus
0.34	GO:0031252	cell leading edge
0.34	GO:0005829	cytosol

0.38

EC:2.3.1.88

GO:0004596

tr|T1EH13|T1EH13_HELRO
Uncharacterized protein
Search

0.47	Hydroxypyruvate isomerase

0.33	GO:0008033	tRNA processing
0.33	GO:0032259	methylation
0.32	GO:0005975	carbohydrate metabolic process

0.63	GO:0008903	hydroxypyruvate isomerase activity
0.33	GO:0008168	methyltransferase activity
0.32	GO:0046872	metal ion binding

0.30

GO:0031224

intrinsic component of membrane

0.63	EC:5.3.1.22	GO:0008903
0.63	KEGG:R01394	GO:0008903

tr|T1EH14|T1EH14_HELRO
Uncharacterized protein
Search

TMEM45A

0.79	Transmembrane protein 45B

0.30

GO:0044425

membrane part

tr|T1EH15|T1EH15_HELRO
Uncharacterized protein
Search

0.64	GO:0007219	Notch signaling pathway
0.57	GO:0030154	cell differentiation
0.56	GO:0007275	multicellular organism development
0.54	GO:0050793	regulation of developmental process
0.47	GO:0045967	negative regulation of growth rate
0.45	GO:0046579	positive regulation of Ras protein signal transduction
0.44	GO:0006355	regulation of transcription, DNA-templated
0.44	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.44	GO:0007050	cell cycle arrest
0.44	GO:0009653	anatomical structure morphogenesis

0.70	GO:0005509	calcium ion binding
0.49	GO:0060089	molecular transducer activity
0.43	GO:0005112	Notch binding
0.40	GO:0003682	chromatin binding
0.40	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.39	GO:0001047	core promoter binding
0.38	GO:0004857	enzyme inhibitor activity
0.38	GO:0046982	protein heterodimerization activity
0.37	GO:0019899	enzyme binding
0.36	GO:0043565	sequence-specific DNA binding

0.43	GO:0043235	receptor complex
0.43	GO:0009986	cell surface
0.41	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex
0.40	GO:0005912	adherens junction
0.39	GO:0044459	plasma membrane part
0.39	GO:0005634	nucleus
0.39	GO:0045177	apical part of cell
0.38	GO:0070013	intracellular organelle lumen
0.38	GO:0031410	cytoplasmic vesicle
0.37	GO:0005783	endoplasmic reticulum

0.34

GO:0004252

tr|T1EH16|T1EH16_HELRO
Uncharacterized protein
Search

0.55	GO:0055085	transmembrane transport
0.39	GO:0009624	response to nematode
0.37	GO:0006820	anion transport
0.37	GO:0009416	response to light stimulus

0.38

GO:0005315

inorganic phosphate transmembrane transporter activity

0.37	GO:0009536	plastid
0.36	GO:0042651	thylakoid membrane
0.36	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

tr|T1EH17|T1EH17_HELRO
Uncharacterized protein
Search

0.61	CCR4-NOT transcription complex subunit 3

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.44	GO:0034249	negative regulation of cellular amide metabolic process
0.44	GO:2000036	regulation of stem cell population maintenance
0.43	GO:0006401	RNA catabolic process
0.43	GO:0001829	trophectodermal cell differentiation
0.43	GO:0032269	negative regulation of cellular protein metabolic process
0.42	GO:0010558	negative regulation of macromolecule biosynthetic process
0.42	GO:0031327	negative regulation of cellular biosynthetic process

0.43	GO:0004535	poly(A)-specific ribonuclease activity
0.36	GO:0005246	calcium channel regulator activity
0.34	GO:0005515	protein binding

0.82	GO:0030015	CCR4-NOT core complex
0.61	GO:0005634	nucleus
0.44	GO:0000932	P-body
0.33	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.43

EC:3.1.13.4

GO:0004535

tr|T1EH18|T1EH18_HELRO
Uncharacterized protein
Search

0.75	Paired box 2

0.70	GO:0007275	multicellular organism development
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:0006355	regulation of transcription, DNA-templated
0.52	GO:0045918	negative regulation of cytolysis
0.50	GO:2000378	negative regulation of reactive oxygen species metabolic process
0.49	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.49	GO:0002009	morphogenesis of an epithelium
0.48	GO:0001763	morphogenesis of a branching structure
0.48	GO:0050679	positive regulation of epithelial cell proliferation
0.46	GO:0090066	regulation of anatomical structure size

0.55	GO:0003677	DNA binding
0.47	GO:0001067	regulatory region nucleic acid binding
0.45	GO:0008134	transcription factor binding
0.40	GO:0016175	superoxide-generating NADPH oxidase activity
0.38	GO:0070742	C2H2 zinc finger domain binding
0.37	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.50	GO:0034451	centriolar satellite
0.45	GO:0005794	Golgi apparatus
0.43	GO:0070013	intracellular organelle lumen
0.37	GO:0005764	lysosome
0.37	GO:0032993	protein-DNA complex
0.35	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.40

EC:1.6.3

GO:0016175

tr|T1EH19|T1EH19_HELRO
Uncharacterized protein
Search

0.44	Putative conserved plasma membrane protein (Fragment)

0.30

GO:0044425

membrane part

tr|T1EH20|T1EH20_HELRO
Uncharacterized protein
Search

0.50	2-aminoethanethiol dioxygenase

0.53	GO:0055114	oxidation-reduction process
0.36	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.36	GO:0006754	ATP biosynthetic process
0.36	GO:0042254	ribosome biogenesis

0.75	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
0.36	GO:0008375	acetylglucosaminyltransferase activity
0.35	GO:0004386	helicase activity
0.35	GO:0015078	hydrogen ion transmembrane transporter activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003676	nucleic acid binding

0.37	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
0.35	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.75

EC:1.13.11

GO:0016702

tr|T1EH21|T1EH21_HELRO
Uncharacterized protein
Search

0.42	GO:0000492	box C/D snoRNP assembly
0.40	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.38	GO:0022008	neurogenesis
0.34	GO:0055085	transmembrane transport

0.54	GO:0046872	metal ion binding
0.34	GO:0022857	transmembrane transporter activity
0.33	GO:0003676	nucleic acid binding

0.34	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

tr|T1EH22|T1EH22_HELRO
Uncharacterized protein
Search

RASD2

0.57	GTP-binding protein Rhes

0.56	GO:0007165	signal transduction
0.44	GO:0001963	synaptic transmission, dopaminergic
0.42	GO:0007626	locomotory behavior
0.37	GO:0033235	positive regulation of protein sumoylation
0.37	GO:0036258	multivesicular body assembly
0.37	GO:0043949	regulation of cAMP-mediated signaling
0.37	GO:0036010	protein localization to endosome
0.36	GO:0051897	positive regulation of protein kinase B signaling
0.36	GO:0031397	negative regulation of protein ubiquitination
0.36	GO:0006895	Golgi to endosome transport

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.51	GO:0031681	G-protein beta-subunit binding
0.37	GO:0043548	phosphatidylinositol 3-kinase binding
0.36	GO:0031624	ubiquitin conjugating enzyme binding
0.34	GO:0004767	sphingomyelin phosphodiesterase activity
0.33	GO:0003688	DNA replication origin binding
0.33	GO:0003682	chromatin binding
0.33	GO:0003678	DNA helicase activity
0.33	GO:0043022	ribosome binding

0.42	GO:0016529	sarcoplasmic reticulum
0.36	GO:0005768	endosome
0.35	GO:0005829	cytosol
0.35	GO:0030139	endocytic vesicle
0.34	GO:0005886	plasma membrane
0.34	GO:0005794	Golgi apparatus
0.34	GO:0098588	bounding membrane of organelle
0.33	GO:0048471	perinuclear region of cytoplasm
0.33	GO:0005634	nucleus
0.33	GO:0042555	MCM complex

0.34	EC:3.1.4.12	GO:0004767
0.34	KEGG:R02541	GO:0004767

tr|T1EH23|T1EH23_HELRO
Uncharacterized protein
Search

0.74	GO:0046710	GDP metabolic process
0.71	GO:0046037	GMP metabolic process
0.51	GO:0097120	receptor localization to synapse
0.51	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
0.51	GO:0043113	receptor clustering
0.50	GO:0030710	regulation of border follicle cell delamination
0.49	GO:0030714	anterior/posterior axis specification, follicular epithelium
0.49	GO:0016310	phosphorylation
0.48	GO:0016336	establishment or maintenance of polarity of larval imaginal disc epithelium
0.48	GO:0016332	establishment or maintenance of polarity of embryonic epithelium

0.74	GO:0004385	guanylate kinase activity
0.52	GO:0035255	ionotropic glutamate receptor binding
0.46	GO:0005154	epidermal growth factor receptor binding
0.39	GO:0004871	signal transducer activity
0.39	GO:0030554	adenyl nucleotide binding
0.39	GO:0097367	carbohydrate derivative binding
0.39	GO:0008144	drug binding
0.39	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0005198	structural molecule activity

0.49	GO:0016323	basolateral plasma membrane
0.48	GO:0045211	postsynaptic membrane
0.47	GO:0005920	smooth septate junction
0.47	GO:0061176	type Ib terminal bouton
0.47	GO:0071212	subsynaptic reticulum
0.46	GO:0061689	tricellular tight junction
0.46	GO:0016327	apicolateral plasma membrane
0.46	GO:0045179	apical cortex
0.45	GO:0042734	presynaptic membrane
0.45	GO:0008328	ionotropic glutamate receptor complex

0.74

EC:2.7.4.8

GO:0004385

tr|T1EH24|T1EH24_HELRO
Uncharacterized protein
Search

0.81	Calcium release-activated calcium channel protein 1

0.41	GO:0002115	store-operated calcium entry
0.39	GO:0070588	calcium ion transmembrane transport
0.36	GO:0051533	positive regulation of NFAT protein import into nucleus
0.35	GO:0051928	positive regulation of calcium ion transport
0.34	GO:0007399	nervous system development
0.32	GO:0055114	oxidation-reduction process

0.41	GO:0015279	store-operated calcium channel activity
0.34	GO:0042802	identical protein binding
0.33	GO:0016787	hydrolase activity
0.32	GO:0016491	oxidoreductase activity

0.33

GO:0005887

integral component of plasma membrane

0.33

GO:0016787

tr|T1EH25|T1EH25_HELRO
Uncharacterized protein
Search

0.86	Mps one binder kinase activator

0.56	GO:0016310	phosphorylation
0.37	GO:0000902	cell morphogenesis
0.37	GO:0042052	rhabdomere development
0.37	GO:0045886	negative regulation of synaptic growth at neuromuscular junction
0.37	GO:0007616	long-term memory
0.36	GO:0031031	positive regulation of septation initiation signaling
0.35	GO:0032147	activation of protein kinase activity
0.34	GO:0034613	cellular protein localization
0.33	GO:0036211	protein modification process
0.33	GO:0044267	cellular protein metabolic process

0.59	GO:0016301	kinase activity
0.36	GO:0019901	protein kinase binding
0.35	GO:0030295	protein kinase activator activity
0.35	GO:0046872	metal ion binding

0.38	GO:0009524	phragmoplast
0.38	GO:0070451	cell hair
0.37	GO:0016028	rhabdomere
0.37	GO:0005856	cytoskeleton
0.36	GO:0034973	Sid2-Mob1 complex
0.36	GO:0031097	medial cortex
0.35	GO:0005935	cellular bud neck
0.35	GO:0005634	nucleus
0.33	GO:0005886	plasma membrane
0.33	GO:0044446	intracellular organelle part

tr|T1EH26|T1EH26_HELRO
Uncharacterized protein
Search

ZFAND2A

0.50	Zinc finger AN1-type containing 2A

0.38	GO:0071243	cellular response to arsenic-containing substance
0.37	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.33	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

0.63	GO:0008270	zinc ion binding
0.33	GO:0004523	RNA-DNA hybrid ribonuclease activity
0.32	GO:0003676	nucleic acid binding

0.36	GO:1905369	endopeptidase complex
0.34	GO:0043234	protein complex
0.34	GO:0005634	nucleus
0.32	GO:0005737	cytoplasm

0.33

EC:3.1.26.4

GO:0004523

tr|T1EH27|T1EH27_HELRO
Uncharacterized protein
Search

0.49	GO:0007165	signal transduction
0.48	GO:0001558	regulation of cell growth
0.47	GO:0045762	positive regulation of adenylate cyclase activity
0.47	GO:0097271	protein localization to bud neck
0.47	GO:0000411	positive regulation of transcription by galactose
0.47	GO:0007190	activation of adenylate cyclase activity
0.47	GO:0070786	positive regulation of growth of unicellular organism as a thread of attached cells
0.47	GO:0060284	regulation of cell development
0.46	GO:0010603	regulation of cytoplasmic mRNA processing body assembly
0.46	GO:0032258	protein localization by the Cvt pathway

0.67	GO:0003924	GTPase activity
0.65	GO:0005525	GTP binding
0.49	GO:0019003	GDP binding
0.46	GO:0002135	CTP binding
0.45	GO:0002134	UTP binding
0.42	GO:0005044	scavenger receptor activity
0.39	GO:0004252	serine-type endopeptidase activity
0.38	GO:0004767	sphingomyelin phosphodiesterase activity
0.35	GO:0005515	protein binding

0.46	GO:0032155	cell division site part
0.46	GO:0098559	cytoplasmic side of early endosome membrane
0.45	GO:0005789	endoplasmic reticulum membrane
0.44	GO:1904115	axon cytoplasm
0.43	GO:0030428	cell septum
0.43	GO:0032580	Golgi cisterna membrane
0.42	GO:0005802	trans-Golgi network
0.42	GO:0035974	meiotic spindle pole body
0.41	GO:0009898	cytoplasmic side of plasma membrane
0.41	GO:0012506	vesicle membrane

0.39	EC:3.4.21	GO:0004252
0.38	KEGG:R02541	GO:0004767

tr|T1EH28|T1EH28_HELRO
Uncharacterized protein
Search

0.55	GO:0016567	protein ubiquitination
0.43	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.43	GO:1903506	regulation of nucleic acid-templated transcription
0.43	GO:0010468	regulation of gene expression

0.55	GO:0004842	ubiquitin-protein transferase activity
0.44	GO:0046872	metal ion binding
0.42	GO:0003700	DNA binding transcription factor activity

0.40	GO:0005634	nucleus
0.30	GO:0044425	membrane part

0.55

KEGG:R03876

GO:0004842

tr|T1EH29|T1EH29_HELRO
Uncharacterized protein
Search

tr|T1EH30|T1EH30_HELRO
Uncharacterized protein
Search

tr|T1EH31|T1EH31_HELRO
Uncharacterized protein
Search

RCAN2

0.82	Calcineurin inhibitory protein ZAKI-4 beta

0.84	GO:0019722	calcium-mediated signaling
0.48	GO:0048016	inositol phosphate-mediated signaling
0.44	GO:0070884	regulation of calcineurin-NFAT signaling cascade
0.41	GO:0043666	regulation of phosphoprotein phosphatase activity
0.37	GO:0031987	locomotion involved in locomotory behavior
0.37	GO:0007614	short-term memory
0.36	GO:0007219	Notch signaling pathway
0.35	GO:0000056	ribosomal small subunit export from nucleus
0.35	GO:0000055	ribosomal large subunit export from nucleus
0.35	GO:0006979	response to oxidative stress

0.51	GO:0003676	nucleic acid binding
0.45	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity
0.35	GO:0017056	structural constituent of nuclear pore

0.45	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

tr|T1EH32|T1EH32_HELRO
Uncharacterized protein
Search

tr|T1EH33|T1EH33_HELRO
Uncharacterized protein
Search

0.52	GO:0050982	detection of mechanical stimulus
0.48	GO:0070588	calcium ion transmembrane transport
0.48	GO:0001822	kidney development
0.45	GO:0098869	cellular oxidant detoxification
0.39	GO:0050915	sensory perception of sour taste
0.39	GO:0055114	oxidation-reduction process
0.36	GO:0060046	regulation of acrosome reaction
0.36	GO:0032259	methylation
0.34	GO:0042981	regulation of apoptotic process
0.33	GO:0015074	DNA integration

0.57	GO:0005509	calcium ion binding
0.49	GO:0005262	calcium channel activity
0.49	GO:0004096	catalase activity
0.43	GO:0020037	heme binding
0.36	GO:0008168	methyltransferase activity
0.35	GO:0030246	carbohydrate binding
0.34	GO:0003676	nucleic acid binding

0.35	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.49

EC:1.11.1.6

GO:0004096

tr|T1EH34|T1EH34_HELRO
Uncharacterized protein
Search

tr|T1EH35|T1EH35_HELRO
Uncharacterized protein
Search

0.62	Inner nuclear membrane protein Man1

0.74	GO:0006997	nucleus organization
0.73	GO:0001525	angiogenesis
0.66	GO:1902531	regulation of intracellular signal transduction
0.50	GO:0030514	negative regulation of BMP signaling pathway
0.48	GO:0032926	negative regulation of activin receptor signaling pathway
0.47	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.46	GO:0070197	meiotic attachment of telomere to nuclear envelope
0.43	GO:0010256	endomembrane system organization
0.40	GO:0061024	membrane organization
0.36	GO:0043534	blood vessel endothelial cell migration

0.51	GO:0003676	nucleic acid binding
0.43	GO:0003682	chromatin binding
0.33	GO:0005515	protein binding

0.83	GO:0031229	intrinsic component of nuclear inner membrane
0.76	GO:0031301	integral component of organelle membrane
0.32	GO:0005739	mitochondrion

tr|T1EH36|T1EH36_HELRO
Uncharacterized protein
Search

0.65	Voltage-sensitive sodium channel (Fragment)

0.75	GO:0035725	sodium ion transmembrane transport
0.73	GO:0034765	regulation of ion transmembrane transport
0.43	GO:0019233	sensory perception of pain
0.40	GO:0019228	neuronal action potential
0.40	GO:0086010	membrane depolarization during action potential
0.35	GO:0045433	male courtship behavior, veined wing generated song production
0.35	GO:0007638	mechanosensory behavior
0.34	GO:0001666	response to hypoxia
0.34	GO:0060078	regulation of postsynaptic membrane potential
0.33	GO:0071804	cellular potassium ion transport

0.82	GO:0005248	voltage-gated sodium channel activity
0.70	GO:0022832	voltage-gated channel activity
0.68	GO:0022839	ion gated channel activity
0.68	GO:0008381	mechanosensitive ion channel activity
0.63	GO:0005509	calcium ion binding
0.35	GO:0008081	phosphoric diester hydrolase activity
0.34	GO:0005267	potassium channel activity

0.81	GO:0001518	voltage-gated sodium channel complex
0.34	GO:0008076	voltage-gated potassium channel complex

0.35

GO:0008081

tr|T1EH37|T1EH37_HELRO
Uncharacterized protein
Search

N4BP2L1

0.56	NEDD4 binding protein 2 like 1

0.57	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.52	GO:0016310	phosphorylation
0.45	GO:0000122	negative regulation of transcription by RNA polymerase II

0.79	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
0.59	GO:0004519	endonuclease activity
0.50	GO:0032559	adenyl ribonucleotide binding
0.49	GO:0008144	drug binding
0.49	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0001106	RNA polymerase II transcription corepressor activity
0.37	GO:0005515	protein binding

0.61	GO:0005829	cytosol
0.47	GO:0042721	mitochondrial inner membrane protein insertion complex
0.40	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.79	EC:2.7.1.78	GO:0046404
0.79	KEGG:R03840	GO:0046404

tr|T1EH38|T1EH38_HELRO
Uncharacterized protein
Search

tr|T1EH39|T1EH39_HELRO
Uncharacterized protein
Search

tr|T1EH40|T1EH40_HELRO
Uncharacterized protein
Search

0.56	GO:0007219	Notch signaling pathway
0.51	GO:0030154	cell differentiation
0.51	GO:0007275	multicellular organism development
0.49	GO:0050793	regulation of developmental process
0.45	GO:0035172	hemocyte proliferation
0.45	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin
0.45	GO:0060250	germ-line stem-cell niche homeostasis
0.45	GO:0002213	defense response to insect
0.45	GO:0009608	response to symbiont
0.45	GO:0050673	epithelial cell proliferation

0.69	GO:0005509	calcium ion binding
0.41	GO:0003682	chromatin binding
0.40	GO:0004872	receptor activity
0.37	GO:0005515	protein binding
0.36	GO:0030247	polysaccharide binding
0.35	GO:0004252	serine-type endopeptidase activity
0.34	GO:0004871	signal transducer activity
0.33	GO:0008270	zinc ion binding
0.33	GO:0005201	extracellular matrix structural constituent
0.33	GO:0008061	chitin binding

0.46	GO:0035003	subapical complex
0.43	GO:0030139	endocytic vesicle
0.43	GO:0005912	adherens junction
0.43	GO:0009986	cell surface
0.42	GO:0005770	late endosome
0.42	GO:0005764	lysosome
0.39	GO:0005576	extracellular region
0.39	GO:0005634	nucleus
0.38	GO:0043234	protein complex
0.38	GO:0016324	apical plasma membrane

0.35

GO:0004252

tr|T1EH41|T1EH41_HELRO
Uncharacterized protein
Search

0.60	Runt-related transcription factor (Fragment)

0.59	GO:0045893	positive regulation of transcription, DNA-templated
0.52	GO:0002062	chondrocyte differentiation
0.49	GO:0006351	transcription, DNA-templated
0.48	GO:0002051	osteoblast fate commitment
0.47	GO:0032332	positive regulation of chondrocyte differentiation
0.47	GO:0042487	regulation of odontogenesis of dentin-containing tooth
0.47	GO:0002076	osteoblast development
0.46	GO:0001958	endochondral ossification
0.46	GO:0035115	embryonic forelimb morphogenesis
0.46	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.46	GO:0043425	bHLH transcription factor binding
0.46	GO:0070491	repressing transcription factor binding
0.44	GO:0001067	regulatory region nucleic acid binding
0.43	GO:0042809	vitamin D receptor binding

0.61	GO:0005634	nucleus
0.43	GO:0000785	chromatin
0.43	GO:0005667	transcription factor complex
0.42	GO:0070013	intracellular organelle lumen
0.36	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EH42|T1EH42_HELRO
Uncharacterized protein
Search

0.68	39S ribosomal protein L47, mitochondrial (inferred by orthology to a human protein)

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.34	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.34	GO:0006754	ATP biosynthetic process
0.33	GO:0043624	cellular protein complex disassembly
0.33	GO:0055114	oxidation-reduction process

0.64	GO:0003735	structural constituent of ribosome
0.33	GO:0015078	hydrogen ion transmembrane transporter activity
0.33	GO:0016491	oxidoreductase activity

0.79	GO:0005761	mitochondrial ribosome
0.48	GO:0000315	organellar large ribosomal subunit
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0019866	organelle inner membrane
0.34	GO:0098798	mitochondrial protein complex
0.34	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)
0.30	GO:0016021	integral component of membrane

0.33

GO:0016491

tr|T1EH43|T1EH43_HELRO
Uncharacterized protein
Search

SOX4

0.54	Sex-determining region Y protein (Fragment)

0.82	GO:0030238	male sex determination
0.77	GO:0007548	sex differentiation
0.68	GO:0030154	cell differentiation
0.55	GO:0006351	transcription, DNA-templated
0.55	GO:2001141	regulation of RNA biosynthetic process
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.38	GO:2000020	positive regulation of male gonad development
0.35	GO:0051254	positive regulation of RNA metabolic process
0.35	GO:0010557	positive regulation of macromolecule biosynthetic process

0.75	GO:0005516	calmodulin binding
0.59	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.35	GO:0008134	transcription factor binding

0.75	GO:0016607	nuclear speck
0.34	GO:0005737	cytoplasm

tr|T1EH44|T1EH44_HELRO
Uncharacterized protein
Search

0.54	GO:0050982	detection of mechanical stimulus
0.50	GO:0070588	calcium ion transmembrane transport
0.47	GO:0001822	kidney development
0.45	GO:0098869	cellular oxidant detoxification
0.39	GO:0055114	oxidation-reduction process
0.35	GO:0032259	methylation
0.34	GO:0006898	receptor-mediated endocytosis

0.57	GO:0005509	calcium ion binding
0.51	GO:0005262	calcium channel activity
0.48	GO:0004096	catalase activity
0.43	GO:0020037	heme binding
0.35	GO:0005044	scavenger receptor activity
0.35	GO:0008168	methyltransferase activity
0.33	GO:0003676	nucleic acid binding

0.30

GO:0031224

intrinsic component of membrane

0.48

EC:1.11.1.6

GO:0004096

tr|T1EH45|T1EH45_HELRO
Uncharacterized protein
Search

tr|T1EH46|T1EH46_HELRO
Uncharacterized protein
Search

0.75	LIM domain only protein 4

0.46	GO:0035483	gastric emptying
0.45	GO:0036011	imaginal disc-derived leg segmentation
0.44	GO:0042220	response to cocaine
0.44	GO:0022416	chaeta development
0.44	GO:0045475	locomotor rhythm
0.43	GO:0007476	imaginal disc-derived wing morphogenesis
0.43	GO:0008593	regulation of Notch signaling pathway
0.41	GO:1903508	positive regulation of nucleic acid-templated transcription
0.40	GO:0010628	positive regulation of gene expression
0.40	GO:0022414	reproductive process

0.54	GO:0046872	metal ion binding
0.36	GO:0005515	protein binding
0.32	GO:0016740	transferase activity

0.35	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.32

GO:0016740

tr|T1EH47|T1EH47_HELRO
Uncharacterized protein
Search

tr|T1EH48|T1EH48_HELRO
Uncharacterized protein
Search

0.45	Polyadenylate-binding protein 2

0.83	GO:1904247	positive regulation of polynucleotide adenylyltransferase activity
0.36	GO:0071222	cellular response to lipopolysaccharide
0.35	GO:0006378	mRNA polyadenylation
0.35	GO:0042981	regulation of apoptotic process
0.35	GO:0000165	MAPK cascade
0.35	GO:0006915	apoptotic process
0.34	GO:0043069	negative regulation of programmed cell death
0.33	GO:0043043	peptide biosynthetic process
0.33	GO:0032259	methylation
0.33	GO:0009059	macromolecule biosynthetic process

0.59	GO:0003723	RNA binding
0.35	GO:0070063	RNA polymerase binding
0.34	GO:0097718	disordered domain specific binding
0.34	GO:0003735	structural constituent of ribosome
0.33	GO:0046982	protein heterodimerization activity
0.33	GO:0042802	identical protein binding
0.33	GO:0008168	methyltransferase activity

0.38	GO:1990251	Mmi1 nuclear focus
0.37	GO:0005844	polysome
0.36	GO:0000790	nuclear chromatin
0.36	GO:0042405	nuclear inclusion body
0.36	GO:0005730	nucleolus
0.34	GO:0097136	Bcl-2 family protein complex
0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.33

GO:0008168

tr|T1EH49|T1EH49_HELRO
Uncharacterized protein
Search

0.60	GO:0070213	protein auto-ADP-ribosylation
0.58	GO:0070198	protein localization to chromosome, telomeric region
0.58	GO:1904355	positive regulation of telomere capping
0.57	GO:1904357	negative regulation of telomere maintenance via telomere lengthening
0.56	GO:0035264	multicellular organism growth
0.56	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.56	GO:0040014	regulation of multicellular organism growth
0.55	GO:0000209	protein polyubiquitination
0.45	GO:0009116	nucleoside metabolic process
0.39	GO:0007165	signal transduction

0.67	GO:0003950	NAD+ ADP-ribosyltransferase activity
0.50	GO:0019899	enzyme binding
0.43	GO:0000062	fatty-acyl-CoA binding
0.39	GO:0005216	ion channel activity
0.38	GO:0002039	p53 binding
0.37	GO:0140096	catalytic activity, acting on a protein
0.37	GO:0016278	lysine N-methyltransferase activity
0.36	GO:0043531	ADP binding
0.36	GO:0004563	beta-N-acetylhexosaminidase activity
0.36	GO:0008270	zinc ion binding

0.58	GO:0000242	pericentriolar material
0.53	GO:0048471	perinuclear region of cytoplasm
0.52	GO:0005635	nuclear envelope
0.36	GO:0000784	nuclear chromosome, telomeric region
0.36	GO:0005871	kinesin complex
0.36	GO:0030529	intracellular ribonucleoprotein complex
0.36	GO:0000139	Golgi membrane
0.35	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.67

EC:2.4.2.30

GO:0003950

tr|T1EH50|T1EH50_HELRO
Uncharacterized protein
Search

0.46

Tenascin

0.75	GO:0051005	negative regulation of lipoprotein lipase activity
0.73	GO:0010519	negative regulation of phospholipase activity
0.72	GO:0048514	blood vessel morphogenesis
0.72	GO:0055091	phospholipid homeostasis
0.70	GO:0070328	triglyceride homeostasis
0.70	GO:0050996	positive regulation of lipid catabolic process
0.68	GO:0060840	artery development
0.68	GO:0042632	cholesterol homeostasis
0.67	GO:0045766	positive regulation of angiogenesis
0.67	GO:0019915	lipid storage

0.70	GO:0004859	phospholipase inhibitor activity
0.68	GO:0005178	integrin binding
0.63	GO:0008083	growth factor activity
0.40	GO:0008201	heparin binding
0.38	GO:0042802	identical protein binding
0.37	GO:0001104	RNA polymerase II transcription cofactor activity
0.36	GO:0005509	calcium ion binding
0.35	GO:0003723	RNA binding

0.66	GO:0005615	extracellular space
0.65	GO:0005769	early endosome
0.62	GO:0009986	cell surface
0.59	GO:0005794	Golgi apparatus
0.42	GO:0031012	extracellular matrix
0.40	GO:0030027	lamellipodium
0.37	GO:0016592	mediator complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1EH51|T1EH51_HELRO
Uncharacterized protein
Search

tr|T1EH52|T1EH52_HELRO
Uncharacterized protein
Search

0.85	Zinc finger Ran-binding domain-containing protein 2

0.43	GO:0042742	defense response to bacterium
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0006621	protein retention in ER lumen
0.32	GO:0015031	protein transport

0.53	GO:0046872	metal ion binding
0.53	GO:0003723	RNA binding
0.47	GO:0030882	lipid antigen binding
0.44	GO:0001530	lipopolysaccharide binding
0.35	GO:0004960	thromboxane receptor activity
0.35	GO:0004957	prostaglandin E receptor activity
0.33	GO:0046923	ER retention sequence binding

0.55	GO:0005634	nucleus
0.37	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part
0.33	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.32	GO:0005783	endoplasmic reticulum
0.30	GO:0016021	integral component of membrane

tr|T1EH53|T1EH53_HELRO
Uncharacterized protein
Search

PABPN1

0.66	Polyadenylate-binding protein 2

0.85	GO:1904247	positive regulation of polynucleotide adenylyltransferase activity
0.42	GO:0060050	positive regulation of protein glycosylation
0.42	GO:0071222	cellular response to lipopolysaccharide
0.41	GO:0031124	mRNA 3'-end processing
0.41	GO:0042981	regulation of apoptotic process
0.41	GO:0043631	RNA polyadenylation
0.41	GO:0006915	apoptotic process
0.41	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
0.41	GO:0000165	MAPK cascade
0.41	GO:0016973	poly(A)+ mRNA export from nucleus

0.59	GO:0003723	RNA binding
0.40	GO:0070063	RNA polymerase binding
0.40	GO:0097718	disordered domain specific binding
0.38	GO:0046982	protein heterodimerization activity
0.38	GO:0042802	identical protein binding
0.35	GO:0043621	protein self-association
0.34	GO:0005509	calcium ion binding
0.33	GO:0000384	first spliceosomal transesterification activity
0.33	GO:0008378	galactosyltransferase activity
0.32	GO:0003735	structural constituent of ribosome

0.43	GO:0042405	nuclear inclusion body
0.40	GO:0097136	Bcl-2 family protein complex
0.38	GO:0030529	intracellular ribonucleoprotein complex
0.37	GO:0016604	nuclear body
0.35	GO:0005737	cytoplasm
0.35	GO:0005730	nucleolus
0.34	GO:0000790	nuclear chromatin
0.34	GO:0031968	organelle outer membrane
0.33	GO:0005886	plasma membrane
0.33	GO:0070274	RES complex

0.33

GO:0008378

tr|T1EH54|T1EH54_HELRO
Uncharacterized protein
Search

0.46	GO:0006355	regulation of transcription, DNA-templated
0.35	GO:0006621	protein retention in ER lumen
0.35	GO:0043484	regulation of RNA splicing
0.34	GO:0006351	transcription, DNA-templated
0.34	GO:0051726	regulation of cell cycle
0.34	GO:0015031	protein transport
0.33	GO:0006508	proteolysis

0.51	GO:0003676	nucleic acid binding
0.46	GO:0046872	metal ion binding
0.39	GO:0003700	DNA binding transcription factor activity
0.36	GO:0046923	ER retention sequence binding
0.34	GO:0004180	carboxypeptidase activity
0.34	GO:0005515	protein binding

0.45	GO:0005634	nucleus
0.34	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

tr|T1EH55|T1EH55_HELRO
Uncharacterized protein
Search

0.52	GO:1901187	regulation of ephrin receptor signaling pathway
0.36	GO:0007165	signal transduction

0.64	GO:0042802	identical protein binding
0.50	GO:0046875	ephrin receptor binding

0.42	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

tr|T1EH56|T1EH56_HELRO
Uncharacterized protein
Search

0.10	Chorion-specific transcription factor GCMb (Fragment)

0.70	GO:0007275	multicellular organism development
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.55	GO:0055074	calcium ion homeostasis
0.51	GO:0072503	cellular divalent inorganic cation homeostasis
0.51	GO:0072502	cellular trivalent inorganic anion homeostasis
0.51	GO:0072501	cellular divalent inorganic anion homeostasis
0.51	GO:0030320	cellular monovalent inorganic anion homeostasis

0.55	GO:0003677	DNA binding
0.51	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.38	GO:0001067	regulatory region nucleic acid binding
0.38	GO:0042826	histone deacetylase binding
0.36	GO:0008134	transcription factor binding
0.35	GO:0008270	zinc ion binding
0.33	GO:0003777	microtubule motor activity
0.33	GO:0008017	microtubule binding
0.33	GO:0003779	actin binding
0.33	GO:0030554	adenyl nucleotide binding

0.61	GO:0005634	nucleus
0.37	GO:0005667	transcription factor complex
0.34	GO:0016459	myosin complex

tr|T1EH57|T1EH57_HELRO
Uncharacterized protein
Search

0.44	GO:0031589	cell-substrate adhesion
0.41	GO:1900141	regulation of oligodendrocyte apoptotic process
0.41	GO:0097241	hematopoietic stem cell migration to bone marrow
0.41	GO:0010934	macrophage cytokine production
0.41	GO:0071307	cellular response to vitamin K
0.41	GO:0033159	negative regulation of protein import into nucleus, translocation
0.40	GO:2000669	negative regulation of dendritic cell apoptotic process
0.40	GO:0035754	B cell chemotaxis
0.40	GO:1900165	negative regulation of interleukin-6 secretion
0.40	GO:0032825	positive regulation of natural killer cell differentiation

0.70	GO:0005509	calcium ion binding
0.52	GO:0005201	extracellular matrix structural constituent
0.42	GO:0030247	polysaccharide binding
0.40	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.40	GO:0030296	protein tyrosine kinase activator activity
0.40	GO:0001786	phosphatidylserine binding
0.39	GO:0030971	receptor tyrosine kinase binding
0.39	GO:0004672	protein kinase activity
0.39	GO:0005245	voltage-gated calcium channel activity
0.38	GO:0060090	molecular adaptor activity

0.51	GO:0005576	extracellular region
0.34	GO:0005581	collagen trimer
0.33	GO:0005737	cytoplasm
0.33	GO:0005886	plasma membrane
0.32	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

tr|T1EH58|T1EH58_HELRO
Uncharacterized protein
Search

0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:0010468	regulation of gene expression
0.33	GO:0097659	nucleic acid-templated transcription
0.33	GO:0010467	gene expression
0.33	GO:0016567	protein ubiquitination
0.33	GO:0034645	cellular macromolecule biosynthetic process

0.64	GO:0043565	sequence-specific DNA binding
0.60	GO:0008270	zinc ion binding
0.33	GO:0004842	ubiquitin-protein transferase activity
0.32	GO:0016874	ligase activity

0.61

GO:0005634

nucleus

0.32	EC:6	GO:0016874
0.33	KEGG:R03876	GO:0004842

tr|T1EH59|T1EH59_HELRO
UDP-glucuronosyltransferase
Search

0.32	UDP-glucuronosyltransferase

0.43	GO:0016999	antibiotic metabolic process
0.33	GO:0055114	oxidation-reduction process

0.69	GO:0016758	transferase activity, transferring hexosyl groups
0.62	GO:0008194	UDP-glycosyltransferase activity
0.33	GO:0016491	oxidoreductase activity

0.39	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0044425	membrane part

0.69

GO:0016758

tr|T1EH60|T1EH60_HELRO
Uncharacterized protein
Search

NUDT14

0.39	Uridine diphosphate glucose pyrophosphatase

0.33	GO:0007219	Notch signaling pathway
0.33	GO:0007275	multicellular organism development

0.56	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
0.52	GO:0046872	metal ion binding
0.36	GO:0042802	identical protein binding
0.35	GO:0042302	structural constituent of cuticle
0.34	GO:0005112	Notch binding

0.30

GO:0031224

intrinsic component of membrane

0.56

EC:3.6.1

GO:0016818

tr|T1EH61|T1EH61_HELRO
Uncharacterized protein
Search

tr|T1EH62|T1EH62_HELRO
Uncharacterized protein
Search

0.74	GO:0006869	lipid transport
0.38	GO:0010886	positive regulation of cholesterol storage
0.38	GO:0034374	low-density lipoprotein particle remodeling
0.38	GO:0034383	low-density lipoprotein particle clearance
0.38	GO:0010744	positive regulation of macrophage derived foam cell differentiation
0.38	GO:0045540	regulation of cholesterol biosynthetic process
0.38	GO:0006642	triglyceride mobilization
0.38	GO:0019433	triglyceride catabolic process
0.38	GO:0048844	artery morphogenesis
0.38	GO:0042159	lipoprotein catabolic process

0.77	GO:0005319	lipid transporter activity
0.38	GO:0035473	lipase binding
0.38	GO:0050750	low-density lipoprotein particle receptor binding
0.37	GO:0008201	heparin binding
0.36	GO:0005543	phospholipid binding
0.35	GO:0045735	nutrient reservoir activity

0.39	GO:0034359	mature chylomicron
0.38	GO:0034363	intermediate-density lipoprotein particle
0.38	GO:0034362	low-density lipoprotein particle
0.38	GO:0070971	endoplasmic reticulum exit site
0.38	GO:0034361	very-low-density lipoprotein particle
0.37	GO:0043025	neuronal cell body
0.35	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1EH63|T1EH63_HELRO
Uncharacterized protein
Search

0.49	PR domain containing 13 (Fragment)

0.45	GO:0000122	negative regulation of transcription by RNA polymerase II
0.45	GO:0016571	histone methylation
0.44	GO:0022008	neurogenesis
0.35	GO:0070932	histone H3 deacetylation
0.34	GO:0006351	transcription, DNA-templated
0.33	GO:0006468	protein phosphorylation
0.33	GO:0035556	intracellular signal transduction

0.51	GO:0003676	nucleic acid binding
0.45	GO:0042054	histone methyltransferase activity
0.45	GO:0003682	chromatin binding
0.36	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
0.34	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.41	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.36

EC:3.5.1.98

GO:0032041

tr|T1EH64|T1EH64_HELRO
Uncharacterized protein
Search

0.72	pre-rRNA-processing protein esf2-like

0.43	GO:0034462	small-subunit processome assembly
0.42	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.42	GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.42	GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.36	GO:0032781	positive regulation of ATPase activity
0.35	GO:0006771	riboflavin metabolic process
0.35	GO:0042727	flavin-containing compound biosynthetic process
0.34	GO:0042364	water-soluble vitamin biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.36	GO:0001671	ATPase activator activity
0.36	GO:0000906	6,7-dimethyl-8-ribityllumazine synthase activity

0.39	GO:0005730	nucleolus
0.36	GO:0030686	90S preribosome
0.36	GO:0009349	riboflavin synthase complex

0.36

EC:5.4

GO:0000906

tr|T1EH65|T1EH65_HELRO
Uncharacterized protein
Search

tr|T1EH66|T1EH66_HELRO
Uncharacterized protein
Search

0.49	GO:0030238	male sex determination
0.39	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.39	GO:1903506	regulation of nucleic acid-templated transcription
0.39	GO:0010468	regulation of gene expression

0.55	GO:0003677	DNA binding
0.41	GO:0003700	DNA binding transcription factor activity

0.61

GO:0005634

nucleus

tr|T1EH67|T1EH67_HELRO
Uncharacterized protein
Search

0.86	General transcription factor ii-i repeat domain-containing protein 2-like protein (Fragment)

0.65

GO:0046983

protein dimerization activity

0.30

GO:0044425

membrane part

tr|T1EH68|T1EH68_HELRO
Uncharacterized protein
Search

tr|T1EH69|T1EH69_HELRO
Uncharacterized protein
Search

0.81	Neuronal calcium sensor

0.34	GO:0050665	hydrogen peroxide biosynthetic process
0.33	GO:0006979	response to oxidative stress
0.33	GO:0098869	cellular oxidant detoxification
0.32	GO:0055114	oxidation-reduction process

0.70	GO:0005509	calcium ion binding
0.34	GO:0016174	NAD(P)H oxidase activity
0.33	GO:0004601	peroxidase activity
0.33	GO:0020037	heme binding

0.30

GO:0031224

intrinsic component of membrane

0.34	EC:1.6.3.1	GO:0016174
0.33	KEGG:R03532	GO:0004601

tr|T1EH70|T1EH70_HELRO
Uncharacterized protein
Search

0.47	GO:1903506	regulation of nucleic acid-templated transcription
0.47	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.46	GO:0010468	regulation of gene expression
0.39	GO:0006351	transcription, DNA-templated
0.35	GO:0071310	cellular response to organic substance
0.35	GO:1902679	negative regulation of RNA biosynthetic process
0.34	GO:0071772	response to BMP
0.34	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.34	GO:0071219	cellular response to molecule of bacterial origin
0.34	GO:0032496	response to lipopolysaccharide

0.51	GO:0003676	nucleic acid binding
0.46	GO:0046872	metal ion binding
0.40	GO:0140110	transcription regulator activity
0.34	GO:0005515	protein binding

0.42	GO:0005634	nucleus
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1EH71|T1EH71_HELRO
Uncharacterized protein
Search

tr|T1EH72|T1EH72_HELRO
Uncharacterized protein
Search

tr|T1EH73|T1EH73_HELRO
Uncharacterized protein
Search

tr|T1EH74|T1EH74_HELRO
Uncharacterized protein
Search

0.62	Fas apoptotic inhibitory molecule 2

0.36	GO:0030968	endoplasmic reticulum unfolded protein response
0.36	GO:0019722	calcium-mediated signaling
0.36	GO:0006108	malate metabolic process
0.36	GO:0006915	apoptotic process
0.35	GO:0006099	tricarboxylic acid cycle
0.34	GO:0005975	carbohydrate metabolic process
0.33	GO:0055085	transmembrane transport

0.36	GO:0030060	L-malate dehydrogenase activity
0.33	GO:0022857	transmembrane transporter activity

0.36	GO:0000324	fungal-type vacuole
0.35	GO:0005783	endoplasmic reticulum
0.34	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.36

EC:1.1.1.37

GO:0030060

tr|T1EH75|T1EH75_HELRO
Uncharacterized protein
Search

0.37	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.37	GO:1903506	regulation of nucleic acid-templated transcription
0.37	GO:0010468	regulation of gene expression
0.33	GO:0032259	methylation

0.51	GO:0003676	nucleic acid binding
0.42	GO:0008270	zinc ion binding
0.35	GO:0003700	DNA binding transcription factor activity
0.33	GO:0008168	methyltransferase activity

0.38

GO:0005634

nucleus

0.33

GO:0008168

tr|T1EH76|T1EH76_HELRO
Uncharacterized protein
Search

tr|T1EH77|T1EH77_HELRO
Uncharacterized protein
Search

0.40	GO:0006581	acetylcholine catabolic process
0.40	GO:0007271	synaptic transmission, cholinergic
0.38	GO:0040012	regulation of locomotion
0.36	GO:0097112	gamma-aminobutyric acid receptor clustering

0.54	GO:0004104	cholinesterase activity
0.38	GO:0042803	protein homodimerization activity

0.36	GO:0045202	synapse
0.35	GO:0030425	dendrite
0.35	GO:0030424	axon
0.33	GO:0005576	extracellular region
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.54

GO:0004104

tr|T1EH78|T1EH78_HELRO
Uncharacterized protein
Search

0.60	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.51	GO:0006357	regulation of transcription by RNA polymerase II
0.45	GO:0070301	cellular response to hydrogen peroxide
0.44	GO:0071356	cellular response to tumor necrosis factor
0.44	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.43	GO:0008284	positive regulation of cell proliferation
0.43	GO:0043066	negative regulation of apoptotic process
0.42	GO:0071224	cellular response to peptidoglycan
0.42	GO:0071316	cellular response to nicotine
0.42	GO:0045084	positive regulation of interleukin-12 biosynthetic process

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.42	GO:0071532	ankyrin repeat binding
0.41	GO:0051059	NF-kappaB binding
0.41	GO:0070491	repressing transcription factor binding
0.41	GO:0047485	protein N-terminus binding
0.41	GO:0033613	activating transcription factor binding
0.41	GO:0042826	histone deacetylase binding
0.40	GO:0042805	actinin binding
0.39	GO:0031625	ubiquitin protein ligase binding

0.64	GO:0071159	NF-kappaB complex
0.61	GO:0005634	nucleus
0.49	GO:0005737	cytoplasm
0.39	GO:0005667	transcription factor complex
0.38	GO:0000785	chromatin
0.37	GO:0070013	intracellular organelle lumen

tr|T1EH79|T1EH79_HELRO
Uncharacterized protein
Search

0.18	Hsp20/alpha crystallin family protein (Fragment)

0.85

GO:0005212

structural constituent of eye lens

tr|T1EH80|T1EH80_HELRO
Uncharacterized protein
Search

tr|T1EH81|T1EH81_HELRO
Uncharacterized protein
Search

0.95	Ecdysteroid-regulated protein (Fragment)

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.45	GO:0035071	salivary gland cell autophagic cell death
0.42	GO:0006914	autophagy
0.41	GO:1902680	positive regulation of RNA biosynthetic process
0.41	GO:0006366	transcription by RNA polymerase II
0.36	GO:0040034	regulation of development, heterochronic
0.36	GO:0001787	natural killer cell proliferation
0.36	GO:0001866	NK T cell proliferation

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity

0.61

GO:0005634

nucleus

tr|T1EH82|T1EH82_HELRO
Uncharacterized protein
Search

TRA2A

0.94	Transformer-2 protein like protein alpha

0.48	GO:0000398	mRNA splicing, via spliceosome
0.40	GO:0006413	translational initiation
0.39	GO:0002181	cytoplasmic translation
0.39	GO:0006446	regulation of translational initiation
0.38	GO:0022618	ribonucleoprotein complex assembly
0.36	GO:0048026	positive regulation of mRNA splicing, via spliceosome
0.34	GO:0006368	transcription elongation from RNA polymerase II promoter
0.34	GO:0016570	histone modification
0.33	GO:0016579	protein deubiquitination
0.33	GO:0006511	ubiquitin-dependent protein catabolic process

0.59	GO:0003723	RNA binding
0.35	GO:0042802	identical protein binding
0.33	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.32	GO:0008168	methyltransferase activity
0.32	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.31	GO:0046872	metal ion binding

0.47	GO:0005730	nucleolus
0.40	GO:0005852	eukaryotic translation initiation factor 3 complex
0.39	GO:0016282	eukaryotic 43S preinitiation complex
0.39	GO:0033290	eukaryotic 48S preinitiation complex
0.35	GO:0016593	Cdc73/Paf1 complex
0.33	GO:0019013	viral nucleocapsid
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0036459

tr|T1EH83|T1EH83_HELRO
Uncharacterized protein
Search

0.64	Solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 (Fragment)

0.35	GO:0097291	renal phosphate ion absorption
0.35	GO:0032416	negative regulation of sodium:proton antiporter activity
0.35	GO:0032782	bile acid secretion
0.35	GO:0003096	renal sodium ion transport
0.35	GO:0051683	establishment of Golgi localization
0.35	GO:0030033	microvillus assembly
0.35	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
0.35	GO:0035414	negative regulation of catenin import into nucleus
0.35	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
0.35	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway

0.77	GO:0032947	protein complex scaffold activity
0.38	GO:0008013	beta-catenin binding
0.38	GO:0019902	phosphatase binding
0.37	GO:0008022	protein C-terminus binding
0.37	GO:0045296	cadherin binding
0.37	GO:0005102	receptor binding
0.35	GO:0017081	chloride channel regulator activity
0.34	GO:0043621	protein self-association
0.34	GO:0030165	PDZ domain binding
0.33	GO:0035091	phosphatidylinositol binding

0.35	GO:0012505	endomembrane system
0.34	GO:0032426	stereocilium tip
0.34	GO:0097225	sperm midpiece
0.34	GO:0031526	brush border membrane
0.34	GO:0005902	microvillus
0.34	GO:0016324	apical plasma membrane
0.34	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0016021	integral component of membrane

tr|T1EH84|T1EH84_HELRO
Uncharacterized protein
Search

tr|T1EH85|T1EH85_HELRO
Uncharacterized protein
Search

0.24	RNA-binding proteins

0.77	GO:1904247	positive regulation of polynucleotide adenylyltransferase activity
0.42	GO:0042981	regulation of apoptotic process
0.42	GO:0071222	cellular response to lipopolysaccharide
0.42	GO:0006915	apoptotic process
0.41	GO:0000165	MAPK cascade
0.41	GO:0016973	poly(A)+ mRNA export from nucleus
0.39	GO:0043069	negative regulation of programmed cell death
0.37	GO:0016071	mRNA metabolic process
0.36	GO:0031123	RNA 3'-end processing
0.36	GO:0043631	RNA polyadenylation

0.59	GO:0003723	RNA binding
0.41	GO:0070063	RNA polymerase binding
0.40	GO:0097718	disordered domain specific binding
0.39	GO:0046982	protein heterodimerization activity
0.39	GO:0042802	identical protein binding
0.35	GO:0043621	protein self-association
0.35	GO:0005509	calcium ion binding
0.33	GO:0004016	adenylate cyclase activity
0.33	GO:0000384	first spliceosomal transesterification activity
0.33	GO:0004930	G-protein coupled receptor activity

0.43	GO:0042405	nuclear inclusion body
0.41	GO:0097136	Bcl-2 family protein complex
0.39	GO:0016604	nuclear body
0.38	GO:0030529	intracellular ribonucleoprotein complex
0.36	GO:0000790	nuclear chromatin
0.36	GO:0005730	nucleolus
0.35	GO:0005741	mitochondrial outer membrane
0.34	GO:0005886	plasma membrane
0.33	GO:0070274	RES complex
0.32	GO:0120114	Sm-like protein family complex

0.33

EC:4.6.1.1

GO:0004016

tr|T1EH86|T1EH86_HELRO
Uncharacterized protein
Search

0.55	Calcineurin regulatory subunit CalB

0.44	GO:0000754	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
0.43	GO:0031505	fungal-type cell wall organization
0.41	GO:0006873	cellular ion homeostasis
0.40	GO:0006470	protein dephosphorylation
0.37	GO:0043666	regulation of phosphoprotein phosphatase activity
0.35	GO:0030447	filamentous growth
0.35	GO:0035690	cellular response to drug
0.34	GO:1990954	establishment of protein localization to meiotic spindle pole body
0.34	GO:0055080	cation homeostasis
0.34	GO:0009405	pathogenesis

0.70	GO:0005509	calcium ion binding
0.44	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity
0.39	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity
0.31	GO:0016740	transferase activity

0.45	GO:0005955	calcineurin complex
0.37	GO:0032153	cell division site
0.34	GO:0035840	old growing cell tip
0.34	GO:0035841	new growing cell tip
0.34	GO:0035974	meiotic spindle pole body
0.34	GO:0044732	mitotic spindle pole body
0.34	GO:0030428	cell septum
0.34	GO:0043332	mating projection tip
0.33	GO:0005773	vacuole
0.33	GO:0005829	cytosol

0.31

GO:0016740

tr|T1EH87|T1EH87_HELRO
Uncharacterized protein
Search

0.45	GO:0048082	regulation of adult chitin-containing cuticle pigmentation
0.44	GO:0040003	chitin-based cuticle development
0.42	GO:0030100	regulation of endocytosis
0.40	GO:0006508	proteolysis
0.35	GO:0070858	negative regulation of bile acid biosynthetic process
0.34	GO:0042632	cholesterol homeostasis

0.66	GO:0005509	calcium ion binding
0.42	GO:0004252	serine-type endopeptidase activity
0.33	GO:0005515	protein binding

0.42	GO:0016324	apical plasma membrane
0.38	GO:0005794	Golgi apparatus
0.35	GO:0005829	cytosol
0.33	GO:0030659	cytoplasmic vesicle membrane
0.30	GO:0016021	integral component of membrane

0.42

GO:0004252

tr|T1EH88|T1EH88_HELRO
Uncharacterized protein
Search

PABPN1

0.58	Polyadenylate-binding protein 2

0.84	GO:1904247	positive regulation of polynucleotide adenylyltransferase activity
0.44	GO:0042981	regulation of apoptotic process
0.44	GO:0071222	cellular response to lipopolysaccharide
0.43	GO:0006915	apoptotic process
0.43	GO:0016973	poly(A)+ mRNA export from nucleus
0.43	GO:0000165	MAPK cascade
0.41	GO:0043069	negative regulation of programmed cell death
0.37	GO:0031124	mRNA 3'-end processing
0.36	GO:0043631	RNA polyadenylation
0.36	GO:0038034	signal transduction in absence of ligand

0.59	GO:0003723	RNA binding
0.42	GO:0097718	disordered domain specific binding
0.42	GO:0070063	RNA polymerase binding
0.40	GO:0046982	protein heterodimerization activity
0.40	GO:0042802	identical protein binding
0.36	GO:0043621	protein self-association
0.35	GO:0005509	calcium ion binding

0.45	GO:0042405	nuclear inclusion body
0.43	GO:0097136	Bcl-2 family protein complex
0.39	GO:0016604	nuclear body
0.39	GO:0030529	intracellular ribonucleoprotein complex
0.37	GO:0000790	nuclear chromatin
0.36	GO:0005730	nucleolus
0.35	GO:0005741	mitochondrial outer membrane
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1EH89|T1EH89_HELRO
Uncharacterized protein
Search

0.60	Sex combs reduced homeobox protein (Fragment)

0.65	GO:0007275	multicellular organism development
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.50	GO:0045617	negative regulation of keratinocyte differentiation
0.50	GO:0045656	negative regulation of monocyte differentiation
0.49	GO:0002686	negative regulation of leukocyte migration
0.49	GO:0001953	negative regulation of cell-matrix adhesion
0.47	GO:0048863	stem cell differentiation
0.45	GO:0006366	transcription by RNA polymerase II

0.64	GO:0043565	sequence-specific DNA binding
0.58	GO:0003700	DNA binding transcription factor activity
0.45	GO:0001012	RNA polymerase II regulatory region DNA binding
0.44	GO:0008134	transcription factor binding
0.44	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.44	GO:0031974	membrane-enclosed lumen
0.42	GO:0012505	endomembrane system
0.40	GO:0044446	intracellular organelle part
0.40	GO:0031090	organelle membrane
0.40	GO:0031975	envelope
0.38	GO:0030054	cell junction

tr|T1EH90|T1EH90_HELRO
Uncharacterized protein
Search

0.54	Krueppel factor 4/sw-like protein (Fragment)

0.52	GO:0032534	regulation of microvillus assembly
0.51	GO:0060576	intestinal epithelial cell development
0.51	GO:0030033	microvillus assembly
0.50	GO:0045600	positive regulation of fat cell differentiation
0.50	GO:0035914	skeletal muscle cell differentiation
0.49	GO:1990823	response to leukemia inhibitory factor
0.49	GO:1903506	regulation of nucleic acid-templated transcription
0.49	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.49	GO:0010468	regulation of gene expression
0.48	GO:0001525	angiogenesis

0.52	GO:0003700	DNA binding transcription factor activity
0.51	GO:0003676	nucleic acid binding
0.37	GO:0008134	transcription factor binding
0.34	GO:0046872	metal ion binding

0.44	GO:0005794	Golgi apparatus
0.44	GO:0005654	nucleoplasm
0.33	GO:0000790	nuclear chromatin
0.30	GO:0031224	intrinsic component of membrane

tr|T1EH91|T1EH91_HELRO
Uncharacterized protein
Search

0.10	Phosphotyrosine interaction domain protein

0.73	GO:0036445	neuronal stem cell division
0.72	GO:0007405	neuroblast proliferation
0.67	GO:0048513	animal organ development
0.66	GO:0050767	regulation of neurogenesis
0.63	GO:0048468	cell development
0.61	GO:0061320	pericardial nephrocyte differentiation
0.61	GO:0042694	muscle cell fate specification
0.61	GO:0007389	pattern specification process
0.61	GO:0009653	anatomical structure morphogenesis
0.61	GO:0009786	regulation of asymmetric cell division

0.46	GO:0051117	ATPase binding
0.38	GO:0003924	GTPase activity
0.38	GO:0005525	GTP binding
0.38	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
0.37	GO:0005112	Notch binding
0.37	GO:0005080	protein kinase C binding
0.36	GO:0019904	protein domain specific binding
0.36	GO:0004725	protein tyrosine phosphatase activity
0.36	GO:0005230	extracellular ligand-gated ion channel activity
0.34	GO:0003735	structural constituent of ribosome

0.54	GO:0005938	cell cortex
0.45	GO:0016323	basolateral plasma membrane
0.37	GO:0045178	basal part of cell
0.35	GO:0043229	intracellular organelle
0.35	GO:0043228	non-membrane-bounded organelle
0.35	GO:0005887	integral component of plasma membrane
0.34	GO:0043227	membrane-bounded organelle
0.34	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0044422	organelle part

0.36

GO:0004725

tr|T1EH92|T1EH92_HELRO
Uncharacterized protein
Search

tr|T1EH93|T1EH93_HELRO
Sodium channel protein
Search

0.37	Sodium channel protein

0.78	GO:0034765	regulation of ion transmembrane transport
0.77	GO:0035725	sodium ion transmembrane transport
0.48	GO:0019233	sensory perception of pain
0.46	GO:0019228	neuronal action potential
0.45	GO:0086010	membrane depolarization during action potential
0.45	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress
0.43	GO:0051402	neuron apoptotic process
0.41	GO:0007399	nervous system development
0.36	GO:0048266	behavioral response to pain
0.35	GO:0006954	inflammatory response

0.84	GO:0005248	voltage-gated sodium channel activity
0.75	GO:0022832	voltage-gated channel activity
0.72	GO:0022839	ion gated channel activity
0.72	GO:0008381	mechanosensitive ion channel activity
0.36	GO:0005509	calcium ion binding
0.34	GO:0044325	ion channel binding
0.34	GO:0031402	sodium ion binding
0.34	GO:0005516	calmodulin binding

0.83	GO:0001518	voltage-gated sodium channel complex
0.44	GO:0033270	paranode region of axon
0.44	GO:0030315	T-tubule
0.43	GO:0014704	intercalated disc
0.35	GO:0005622	intracellular
0.34	GO:0033268	node of Ranvier
0.34	GO:0043025	neuronal cell body

tr|T1EH94|T1EH94_HELRO
Uncharacterized protein
Search

0.57	AT-rich interactive domain-containing protein 3A (Fragment)

0.49	GO:0045944	positive regulation of transcription by RNA polymerase II
0.49	GO:0006366	transcription by RNA polymerase II
0.36	GO:0007275	multicellular organism development
0.35	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
0.34	GO:0045165	cell fate commitment
0.34	GO:0016024	CDP-diacylglycerol biosynthetic process
0.34	GO:0000122	negative regulation of transcription by RNA polymerase II
0.33	GO:0007186	G-protein coupled receptor signaling pathway

0.55	GO:0003677	DNA binding
0.51	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.49	GO:0001067	regulatory region nucleic acid binding
0.46	GO:0003682	chromatin binding
0.46	GO:0042803	protein homodimerization activity
0.34	GO:0004605	phosphatidate cytidylyltransferase activity
0.33	GO:0004930	G-protein coupled receptor activity

0.61	GO:0005634	nucleus
0.47	GO:0045121	membrane raft
0.43	GO:0005829	cytosol
0.43	GO:0043233	organelle lumen
0.40	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

0.34

EC:2.7.7.41

GO:0004605

tr|T1EH95|T1EH95_HELRO
Uncharacterized protein
Search

MRPS28

0.74	28S ribosomal protein S28, mitochondrial

0.39	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine
0.35	GO:0070126	mitochondrial translational termination
0.35	GO:0070125	mitochondrial translational elongation
0.35	GO:0006457	protein folding
0.34	GO:0010466	negative regulation of peptidase activity
0.34	GO:0030183	B cell differentiation
0.33	GO:0097428	protein maturation by iron-sulfur cluster transfer

0.34	GO:0003723	RNA binding
0.34	GO:0030414	peptidase inhibitor activity
0.33	GO:0042803	protein homodimerization activity
0.33	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
0.33	GO:0046982	protein heterodimerization activity
0.33	GO:0005509	calcium ion binding
0.32	GO:0051536	iron-sulfur cluster binding
0.32	GO:0005198	structural molecule activity

0.55	GO:0005840	ribosome
0.45	GO:0005759	mitochondrial matrix
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0019866	organelle inner membrane
0.33	GO:0048471	perinuclear region of cytoplasm
0.33	GO:0005576	extracellular region
0.33	GO:0005783	endoplasmic reticulum
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0016747

tr|T1EH96|T1EH96_HELRO
Uncharacterized protein
Search

SP6

0.69	Transcription factor Sp6

0.48	GO:0042481	regulation of odontogenesis
0.45	GO:0008284	positive regulation of cell proliferation
0.43	GO:0006357	regulation of transcription by RNA polymerase II
0.42	GO:0009887	animal organ morphogenesis
0.41	GO:0036342	post-anal tail morphogenesis
0.40	GO:0035218	leg disc development
0.40	GO:0060348	bone development
0.40	GO:0035107	appendage morphogenesis
0.39	GO:0048737	imaginal disc-derived appendage development
0.39	GO:0048707	instar larval or pupal morphogenesis

0.51	GO:0003676	nucleic acid binding
0.43	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.33	GO:0046872	metal ion binding
0.33	GO:0016805	dipeptidase activity
0.32	GO:0016301	kinase activity

0.42	GO:0005634	nucleus
0.35	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.33

EC:3.4.13

GO:0016805

tr|T1EH97|T1EH97_HELRO
Uncharacterized protein
Search

SRP19

0.44	Signal recognition particle

0.74	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.43	GO:0065002	intracellular protein transmembrane transport
0.42	GO:0043623	cellular protein complex assembly
0.40	GO:0042493	response to drug

0.77	GO:0008312	7S RNA binding
0.41	GO:0043022	ribosome binding
0.34	GO:0005515	protein binding
0.32	GO:0016787	hydrolase activity

0.76	GO:0048500	signal recognition particle
0.41	GO:0005730	nucleolus
0.34	GO:0005829	cytosol

0.32

GO:0016787

tr|T1EH98|T1EH98_HELRO
Uncharacterized protein
Search

0.63	Disks large 1 tumor suppressor protein (Fragment)

0.65	GO:0046710	GDP metabolic process
0.62	GO:0046037	GMP metabolic process
0.59	GO:0097120	receptor localization to synapse
0.59	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
0.59	GO:0043113	receptor clustering
0.54	GO:0007268	chemical synaptic transmission
0.52	GO:0007399	nervous system development
0.51	GO:0030710	regulation of border follicle cell delamination
0.51	GO:0030714	anterior/posterior axis specification, follicular epithelium
0.50	GO:0016336	establishment or maintenance of polarity of larval imaginal disc epithelium

0.65	GO:0004385	guanylate kinase activity
0.60	GO:0035255	ionotropic glutamate receptor binding
0.47	GO:0005154	epidermal growth factor receptor binding
0.40	GO:0004871	signal transducer activity
0.40	GO:0005198	structural molecule activity

0.58	GO:0008328	ionotropic glutamate receptor complex
0.57	GO:0014069	postsynaptic density
0.56	GO:0016323	basolateral plasma membrane
0.55	GO:0045211	postsynaptic membrane
0.49	GO:0005920	smooth septate junction
0.49	GO:0061176	type Ib terminal bouton
0.49	GO:0071212	subsynaptic reticulum
0.48	GO:0061689	tricellular tight junction
0.47	GO:0016327	apicolateral plasma membrane
0.47	GO:0045179	apical cortex

0.65

EC:2.7.4.8

GO:0004385

tr|T1EH99|T1EH99_HELRO
Uncharacterized protein
Search

RPS10

0.63	Small subunit ribosomal protein S10e

0.43	GO:0000028	ribosomal small subunit assembly
0.35	GO:0002181	cytoplasmic translation
0.33	GO:0006278	RNA-dependent DNA biosynthetic process
0.33	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.38	GO:0003735	structural constituent of ribosome
0.37	GO:0003723	RNA binding
0.33	GO:0003964	RNA-directed DNA polymerase activity
0.33	GO:0004519	endonuclease activity
0.33	GO:0005515	protein binding
0.32	GO:0046872	metal ion binding

0.58	GO:0005840	ribosome
0.40	GO:0044445	cytosolic part
0.37	GO:0044446	intracellular organelle part
0.33	GO:0005634	nucleus

0.33

GO:0003964

tr|T1EHA0|T1EHA0_HELRO
Uncharacterized protein
Search

0.51	Sesquipedalian-1

0.80	GO:0007032	endosome organization
0.79	GO:0001881	receptor recycling
0.72	GO:0042147	retrograde transport, endosome to Golgi
0.45	GO:0032012	regulation of ARF protein signal transduction
0.41	GO:0065009	regulation of molecular function
0.39	GO:0006869	lipid transport
0.38	GO:0006468	protein phosphorylation

0.54	GO:0042803	protein homodimerization activity
0.45	GO:0005086	ARF guanyl-nucleotide exchange factor activity
0.38	GO:0004672	protein kinase activity
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding

0.78	GO:0055037	recycling endosome
0.72	GO:0005769	early endosome
0.71	GO:0005802	trans-Golgi network
0.62	GO:0005829	cytosol

tr|T1EHA1|T1EHA1_HELRO
Uncharacterized protein
Search

0.72	GO:0006470	protein dephosphorylation
0.37	GO:0016310	phosphorylation

0.79	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.57	GO:0004725	protein tyrosine phosphatase activity
0.37	GO:0016301	kinase activity

0.79

EC:3.1.3

GO:0008138

tr|T1EHA2|T1EHA2_HELRO
Uncharacterized protein
Search

tr|T1EHA3|T1EHA3_HELRO
Uncharacterized protein
Search

MRPL20

0.43	Mitochondrial ribosomal protein L20

0.60	GO:0043043	peptide biosynthetic process
0.58	GO:0000027	ribosomal large subunit assembly
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.36	GO:0043624	cellular protein complex disassembly

0.66	GO:0019843	rRNA binding
0.64	GO:0003735	structural constituent of ribosome
0.34	GO:0005515	protein binding

0.61	GO:0005840	ribosome
0.58	GO:0005759	mitochondrial matrix
0.36	GO:0031966	mitochondrial membrane
0.36	GO:0019866	organelle inner membrane

tr|T1EHA4|T1EHA4_HELRO
Uncharacterized protein
Search

tr|T1EHA5|T1EHA5_HELRO
Uncharacterized protein
Search

0.97	Pax-beta paired domain protein (Fragment)

0.70	GO:0007275	multicellular organism development
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.39	GO:1902680	positive regulation of RNA biosynthetic process
0.33	GO:0006030	chitin metabolic process

0.57	GO:0043565	sequence-specific DNA binding
0.43	GO:0008270	zinc ion binding
0.41	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.40	GO:0001012	RNA polymerase II regulatory region DNA binding
0.39	GO:0003690	double-stranded DNA binding
0.33	GO:0008061	chitin binding

0.61	GO:0005634	nucleus
0.33	GO:0005576	extracellular region

tr|T1EHA6|T1EHA6_HELRO
Uncharacterized protein
Search

0.82	GO:0007616	long-term memory
0.69	GO:0051259	protein oligomerization
0.47	GO:1903507	negative regulation of nucleic acid-templated transcription
0.43	GO:0023052	signaling
0.41	GO:0010468	regulation of gene expression

0.52	GO:0003714	transcription corepressor activity
0.44	GO:0005515	protein binding
0.40	GO:0032559	adenyl ribonucleotide binding
0.40	GO:0008144	drug binding
0.40	GO:0035639	purine ribonucleoside triphosphate binding

0.76	GO:0044297	cell body
0.75	GO:0097060	synaptic membrane
0.48	GO:0005634	nucleus
0.38	GO:0005737	cytoplasm

tr|T1EHA7|T1EHA7_HELRO
Uncharacterized protein
Search

tr|T1EHA8|T1EHA8_HELRO
Uncharacterized protein
Search

0.10	Dopamine D2 receptor (Fragment)

0.75	GO:0007212	dopamine receptor signaling pathway
0.72	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.53	GO:0051967	negative regulation of synaptic transmission, glutamatergic
0.53	GO:0060359	response to ammonium ion
0.53	GO:0014059	regulation of dopamine secretion
0.52	GO:0048149	behavioral response to ethanol
0.52	GO:0072347	response to anesthetic
0.52	GO:0060160	negative regulation of dopamine receptor signaling pathway
0.51	GO:0043279	response to alkaloid
0.51	GO:0051944	positive regulation of catecholamine uptake involved in synaptic transmission

0.76	GO:0004952	dopamine neurotransmitter receptor activity
0.53	GO:0035240	dopamine binding
0.48	GO:0008227	G-protein coupled amine receptor activity
0.45	GO:0042802	identical protein binding
0.43	GO:0099528	G-protein coupled neurotransmitter receptor activity
0.41	GO:0015464	acetylcholine receptor activity
0.38	GO:0035255	ionotropic glutamate receptor binding
0.37	GO:0051378	serotonin binding
0.36	GO:0099589	serotonin receptor activity
0.36	GO:0046982	protein heterodimerization activity

0.60	GO:0005887	integral component of plasma membrane
0.49	GO:0060170	ciliary membrane
0.47	GO:0097730	non-motile cilium
0.47	GO:0097458	neuron part
0.43	GO:0099501	exocytic vesicle membrane
0.41	GO:0044456	synapse part
0.37	GO:0016328	lateral plasma membrane
0.37	GO:0036126	sperm flagellum
0.37	GO:0001669	acrosomal vesicle
0.37	GO:0032279	asymmetric synapse

0.34

GO:0004715

tr|T1EHA9|T1EHA9_HELRO
Uncharacterized protein
Search

0.10	Fer3-like bHLH transcription factor

0.59	GO:0035881	amacrine cell differentiation
0.56	GO:0031016	pancreas development
0.53	GO:0061074	regulation of neural retina development
0.53	GO:0048384	retinoic acid receptor signaling pathway
0.52	GO:0010842	retina layer formation
0.52	GO:0030902	hindbrain development
0.51	GO:0009888	tissue development
0.51	GO:0048663	neuron fate commitment
0.50	GO:0045893	positive regulation of transcription, DNA-templated
0.48	GO:0035272	exocrine system development

0.68	GO:0046983	protein dimerization activity
0.52	GO:0070888	E-box binding
0.50	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.48	GO:0003682	chromatin binding
0.39	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.35	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.35	GO:0042802	identical protein binding

0.48	GO:0005667	transcription factor complex
0.38	GO:0005634	nucleus
0.34	GO:0005737	cytoplasm
0.33	GO:0005856	cytoskeleton
0.33	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part

tr|T1EHB0|T1EHB0_HELRO
Uncharacterized protein
Search

tr|T1EHB1|T1EHB1_HELRO
Uncharacterized protein
Search

TRAPPC2L

0.93	Trafficking protein particle complex 2 like

0.78	GO:0006888	ER to Golgi vesicle-mediated transport
0.36	GO:0051259	protein oligomerization
0.34	GO:0006901	vesicle coating
0.34	GO:0048199	vesicle targeting, to, from or within Golgi
0.34	GO:0048194	Golgi vesicle budding
0.33	GO:0065009	regulation of molecular function

0.34

GO:0017112

Rab guanyl-nucleotide exchange factor activity

0.49	GO:0005737	cytoplasm
0.42	GO:0030008	TRAPP complex
0.40	GO:0043231	intracellular membrane-bounded organelle
0.38	GO:0012505	endomembrane system
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0031984	organelle subcompartment
0.30	GO:0031224	intrinsic component of membrane

tr|T1EHB2|T1EHB2_HELRO
Uncharacterized protein
Search

0.82	F-type H+-transporting ATPase subunit f

0.30

GO:0044425

membrane part

tr|T1EHB3|T1EHB3_HELRO
Uncharacterized protein
Search

tr|T1EHB4|T1EHB4_HELRO
Uncharacterized protein
Search

tr|T1EHB5|T1EHB5_HELRO
Uncharacterized protein
Search

0.50	GO:0032509	endosome transport via multivesicular body sorting pathway
0.48	GO:0035335	peptidyl-tyrosine dephosphorylation
0.43	GO:0015031	protein transport

0.48

GO:0004725

protein tyrosine phosphatase activity

0.50	GO:0000813	ESCRT I complex
0.30	GO:0016021	integral component of membrane

0.48

GO:0004725

tr|T1EHB6|T1EHB6_HELRO
Uncharacterized protein
Search

0.11	E3 ubiquitin-protein ligase hrd-1

0.45	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.45	GO:0036503	ERAD pathway
0.44	GO:0016567	protein ubiquitination
0.37	GO:0042981	regulation of apoptotic process
0.33	GO:0055114	oxidation-reduction process

0.56	GO:0016874	ligase activity
0.45	GO:0061630	ubiquitin protein ligase activity
0.45	GO:0008270	zinc ion binding
0.35	GO:0050660	flavin adenine dinucleotide binding
0.35	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors

0.46	GO:0000836	Hrd1p ubiquitin ligase complex
0.30	GO:0016021	integral component of membrane

0.56

GO:0016874

tr|T1EHB7|T1EHB7_HELRO
Uncharacterized protein
Search

0.10	Zinc-finger transcription factor (Fragment)

0.48	GO:0035155	negative regulation of terminal cell fate specification, open tracheal system
0.47	GO:0035310	notum cell fate specification
0.47	GO:0048098	antennal joint development
0.47	GO:0007438	oenocyte development
0.47	GO:0045465	R8 cell differentiation
0.46	GO:0035277	spiracle morphogenesis, open tracheal system
0.46	GO:0045466	R7 cell differentiation
0.45	GO:0030539	male genitalia development
0.45	GO:0007525	somatic muscle development
0.45	GO:0048644	muscle organ morphogenesis

0.51	GO:0003676	nucleic acid binding
0.35	GO:0003700	DNA binding transcription factor activity
0.34	GO:0046872	metal ion binding
0.32	GO:0005515	protein binding

0.40

GO:0005634

nucleus

tr|T1EHB8|T1EHB8_HELRO
Histone H2A
Search

tr|T1EHB9|T1EHB9_HELRO
Uncharacterized protein
Search

0.10	Zinc-finger transcription factor (Fragment)

0.47	GO:0035107	appendage morphogenesis
0.46	GO:0035155	negative regulation of terminal cell fate specification, open tracheal system
0.46	GO:0035310	notum cell fate specification
0.45	GO:0007438	oenocyte development
0.45	GO:0045465	R8 cell differentiation
0.45	GO:0035277	spiracle morphogenesis, open tracheal system
0.45	GO:0045466	R7 cell differentiation
0.44	GO:0035214	eye-antennal disc development
0.44	GO:0030539	male genitalia development
0.44	GO:0007525	somatic muscle development

0.51	GO:0003676	nucleic acid binding
0.40	GO:0003682	chromatin binding
0.36	GO:0003700	DNA binding transcription factor activity
0.34	GO:0046872	metal ion binding
0.32	GO:0005515	protein binding

0.40

GO:0005634

nucleus

tr|T1EHC0|T1EHC0_HELRO
Uncharacterized protein
Search

tr|T1EHC1|T1EHC1_HELRO
Uncharacterized protein
Search

0.80	Negative cofactor 2 transcriptional co-repressor (Fragment)

0.46	GO:0051123	RNA polymerase II transcriptional preinitiation complex assembly
0.45	GO:0000122	negative regulation of transcription by RNA polymerase II
0.43	GO:0045944	positive regulation of transcription by RNA polymerase II

0.74	GO:0046982	protein heterodimerization activity
0.47	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
0.46	GO:0042802	identical protein binding
0.43	GO:0008134	transcription factor binding
0.37	GO:0003714	transcription corepressor activity
0.34	GO:0003677	DNA binding
0.33	GO:0003899	DNA-directed 5'-3' RNA polymerase activity

0.59

GO:0005634

nucleus

0.33

GO:0003899

tr|T1EHC2|T1EHC2_HELRO
Uncharacterized protein
Search

0.69	Lbx homeobox transcription factor (Fragment)

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.49	GO:0051450	myoblast proliferation
0.49	GO:0048856	anatomical structure development
0.47	GO:0030154	cell differentiation
0.47	GO:0042659	regulation of cell fate specification
0.47	GO:0032501	multicellular organismal process
0.47	GO:0051960	regulation of nervous system development
0.47	GO:0060284	regulation of cell development

0.64	GO:0043565	sequence-specific DNA binding
0.41	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.39	GO:0047485	protein N-terminus binding
0.39	GO:0008022	protein C-terminus binding
0.39	GO:0001012	RNA polymerase II regulatory region DNA binding
0.38	GO:0003682	chromatin binding
0.38	GO:0003690	double-stranded DNA binding
0.33	GO:0017137	Rab GTPase binding
0.33	GO:0004000	adenosine deaminase activity
0.32	GO:0008134	transcription factor binding

0.61	GO:0005634	nucleus
0.39	GO:0005667	transcription factor complex
0.30	GO:0016021	integral component of membrane

0.33

GO:0004000

tr|T1EHC3|T1EHC3_HELRO
Uncharacterized protein
Search

tr|T1EHC4|T1EHC4_HELRO
Uncharacterized protein
Search

tr|T1EHC5|T1EHC5_HELRO
Uncharacterized protein
Search

0.68	GO:0006278	RNA-dependent DNA biosynthetic process
0.37	GO:0035335	peptidyl-tyrosine dephosphorylation
0.36	GO:0042981	regulation of apoptotic process
0.35	GO:1902600	hydrogen ion transmembrane transport
0.35	GO:0022900	electron transport chain
0.35	GO:0006508	proteolysis
0.34	GO:0007165	signal transduction

0.69	GO:0003964	RNA-directed DNA polymerase activity
0.37	GO:0004725	protein tyrosine phosphatase activity
0.36	GO:0004252	serine-type endopeptidase activity
0.36	GO:0005509	calcium ion binding
0.35	GO:0004888	transmembrane signaling receptor activity
0.35	GO:0015002	heme-copper terminal oxidase activity
0.35	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.35	GO:0015078	hydrogen ion transmembrane transporter activity
0.35	GO:0008270	zinc ion binding
0.35	GO:0009055	electron transfer activity

0.35	GO:0005887	integral component of plasma membrane
0.35	GO:0005740	mitochondrial envelope

0.69

GO:0003964

tr|T1EHC6|T1EHC6_HELRO
Uncharacterized protein
Search

tr|T1EHC7|T1EHC7_HELRO
Uncharacterized protein
Search

0.52	Zinc finger protein 92 (Fragment)

0.43	GO:1903506	regulation of nucleic acid-templated transcription
0.43	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.43	GO:0010468	regulation of gene expression
0.38	GO:0040034	regulation of development, heterochronic
0.35	GO:1902679	negative regulation of RNA biosynthetic process
0.34	GO:0006351	transcription, DNA-templated
0.33	GO:0032259	methylation

0.51	GO:0003676	nucleic acid binding
0.40	GO:0046872	metal ion binding
0.38	GO:0003700	DNA binding transcription factor activity
0.33	GO:0008168	methyltransferase activity

0.39	GO:0005634	nucleus
0.33	GO:0015630	microtubule cytoskeleton
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0019013	viral nucleocapsid
0.32	GO:0044446	intracellular organelle part
0.32	GO:0030529	intracellular ribonucleoprotein complex

0.33

GO:0008168

tr|T1EHC8|T1EHC8_HELRO
Uncharacterized protein
Search

tr|T1EHC9|T1EHC9_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.45	GO:0048513	animal organ development
0.44	GO:0060322	head development
0.43	GO:0007417	central nervous system development
0.39	GO:0007166	cell surface receptor signaling pathway
0.39	GO:0048598	embryonic morphogenesis
0.38	GO:0060429	epithelium development
0.38	GO:0007600	sensory perception
0.37	GO:0022405	hair cycle process
0.37	GO:0030154	cell differentiation

0.70	GO:0005509	calcium ion binding
0.37	GO:0004930	G-protein coupled receptor activity
0.36	GO:0042803	protein homodimerization activity

0.55	GO:0005886	plasma membrane
0.37	GO:0030057	desmosome
0.37	GO:0032420	stereocilium
0.30	GO:0016021	integral component of membrane

tr|T1EHD0|T1EHD0_HELRO
Uncharacterized protein
Search

0.66	40S ribosomal protein S24

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.40	GO:0060215	primitive hemopoiesis
0.40	GO:0060216	definitive hemopoiesis
0.39	GO:0042274	ribosomal small subunit biogenesis
0.38	GO:0016072	rRNA metabolic process

0.64

GO:0003735

structural constituent of ribosome

0.61	GO:0005840	ribosome
0.38	GO:0044445	cytosolic part
0.36	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

tr|T1EHD1|T1EHD1_HELRO
Uncharacterized protein
Search

0.77	GO:0070588	calcium ion transmembrane transport
0.45	GO:0006828	manganese ion transport
0.45	GO:0051480	regulation of cytosolic calcium ion concentration
0.38	GO:0007338	single fertilization

0.80

GO:0005262

calcium channel activity

0.41

GO:0005887

integral component of plasma membrane

tr|T1EHD2|T1EHD2_HELRO
Uncharacterized protein
Search

0.65	GO:0006278	RNA-dependent DNA biosynthetic process
0.37	GO:0035335	peptidyl-tyrosine dephosphorylation
0.36	GO:0006898	receptor-mediated endocytosis
0.36	GO:0006508	proteolysis
0.36	GO:0015074	DNA integration
0.34	GO:1902600	hydrogen ion transmembrane transport
0.34	GO:0022900	electron transport chain

0.66	GO:0003964	RNA-directed DNA polymerase activity
0.37	GO:0005044	scavenger receptor activity
0.37	GO:0005201	extracellular matrix structural constituent
0.37	GO:0004252	serine-type endopeptidase activity
0.37	GO:0004725	protein tyrosine phosphatase activity
0.35	GO:0046983	protein dimerization activity
0.35	GO:0015002	heme-copper terminal oxidase activity
0.35	GO:0016675	oxidoreductase activity, acting on a heme group of donors
0.35	GO:0016874	ligase activity
0.34	GO:0015078	hydrogen ion transmembrane transporter activity

0.34	GO:0005740	mitochondrial envelope
0.30	GO:0016020	membrane

0.66

GO:0003964

tr|T1EHD3|T1EHD3_HELRO
Uncharacterized protein
Search

tr|T1EHD4|T1EHD4_HELRO
Uncharacterized protein
Search

0.63	GO:0006468	protein phosphorylation
0.45	GO:0035329	hippo signaling
0.42	GO:0000278	mitotic cell cycle
0.38	GO:0042149	cellular response to glucose starvation
0.37	GO:0032007	negative regulation of TOR signaling
0.37	GO:0018209	peptidyl-serine modification
0.36	GO:0031098	stress-activated protein kinase signaling cascade
0.36	GO:0016570	histone modification
0.36	GO:0032147	activation of protein kinase activity
0.35	GO:0007346	regulation of mitotic cell cycle

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0005509	calcium ion binding
0.36	GO:0060089	molecular transducer activity
0.35	GO:0005216	ion channel activity
0.35	GO:0004356	glutamate-ammonia ligase activity
0.34	GO:0034450	ubiquitin-ubiquitin ligase activity
0.34	GO:0008234	cysteine-type peptidase activity

0.38	GO:0031588	nucleotide-activated protein kinase complex
0.37	GO:0005634	nucleus
0.35	GO:0005737	cytoplasm
0.34	GO:0098794	postsynapse
0.34	GO:0000151	ubiquitin ligase complex
0.33	GO:0031982	vesicle
0.33	GO:0099512	supramolecular fiber
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.32	GO:0005886	plasma membrane
0.32	GO:0044422	organelle part

0.35	EC:6.3.1.2	GO:0004356
0.35	KEGG:R00253	GO:0004356

tr|T1EHD5|T1EHD5_HELRO
Uncharacterized protein
Search

tr|T1EHD6|T1EHD6_HELRO
Uncharacterized protein
Search

0.71	GO:0060079	excitatory postsynaptic potential
0.60	GO:0034220	ion transmembrane transport
0.45	GO:0006511	ubiquitin-dependent protein catabolic process
0.32	GO:0006812	cation transport

0.76	GO:0005230	extracellular ligand-gated ion channel activity
0.74	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
0.70	GO:0004888	transmembrane signaling receptor activity
0.69	GO:0022835	transmitter-gated channel activity
0.68	GO:0140135	mechanosensitive cation channel activity
0.47	GO:0031625	ubiquitin protein ligase binding
0.44	GO:0005509	calcium ion binding

0.71	GO:0045211	postsynaptic membrane
0.67	GO:0030054	cell junction
0.40	GO:0031461	cullin-RING ubiquitin ligase complex
0.30	GO:0016021	integral component of membrane

tr|T1EHD7|T1EHD7_HELRO
Uncharacterized protein
Search

0.10	Putative enspm-2 hm 1p hydra transposon (Fragment)

0.48	GO:0048478	replication fork protection
0.46	GO:0006915	apoptotic process
0.42	GO:0007049	cell cycle
0.42	GO:0006974	cellular response to DNA damage stimulus

0.39	GO:0008270	zinc ion binding
0.36	GO:0003676	nucleic acid binding

0.40	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EHD8|T1EHD8_HELRO
Uncharacterized protein
Search

ODSH

0.74	Homeobox protein unc-4 like protein (Fragment)

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:0007275	multicellular organism development
0.44	GO:0030154	cell differentiation
0.42	GO:0007601	visual perception
0.42	GO:0009653	anatomical structure morphogenesis
0.42	GO:0071695	anatomical structure maturation
0.42	GO:0035726	common myeloid progenitor cell proliferation
0.41	GO:0098743	cell aggregation

0.64	GO:0043565	sequence-specific DNA binding
0.38	GO:0003682	chromatin binding
0.38	GO:0044212	transcription regulatory region DNA binding
0.35	GO:0003700	DNA binding transcription factor activity
0.33	GO:0016208	AMP binding
0.33	GO:0003987	acetate-CoA ligase activity
0.32	GO:0005524	ATP binding

0.61	GO:0005634	nucleus
0.36	GO:0030424	axon
0.36	GO:0045202	synapse
0.30	GO:0016020	membrane

0.33

EC:6.2.1.1

GO:0003987

tr|T1EHD9|T1EHD9_HELRO
Uncharacterized protein
Search

0.72	GO:0071875	adrenergic receptor signaling pathway
0.47	GO:0007218	neuropeptide signaling pathway
0.38	GO:1901652	response to peptide
0.38	GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
0.37	GO:0032870	cellular response to hormone stimulus
0.37	GO:0045907	positive regulation of vasoconstriction
0.37	GO:0045987	positive regulation of smooth muscle contraction
0.37	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
0.37	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.36	GO:0007204	positive regulation of cytosolic calcium ion concentration

0.74	GO:0004937	alpha1-adrenergic receptor activity
0.47	GO:0008188	neuropeptide receptor activity
0.47	GO:0004997	thyrotropin-releasing hormone receptor activity
0.38	GO:0042277	peptide binding

0.49	GO:0005886	plasma membrane
0.32	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

tr|T1EHE0|T1EHE0_HELRO
Uncharacterized protein
Search

tr|T1EHE1|T1EHE1_HELRO
Uncharacterized protein
Search

tr|T1EHE2|T1EHE2_HELRO
Uncharacterized protein
Search

0.66	Interferon regulatory factor protein 4a

0.57	GO:0006351	transcription, DNA-templated
0.56	GO:0045368	positive regulation of interleukin-13 biosynthetic process
0.56	GO:0006355	regulation of transcription, DNA-templated
0.56	GO:0045404	positive regulation of interleukin-4 biosynthetic process
0.56	GO:0045082	positive regulation of interleukin-10 biosynthetic process
0.54	GO:0045086	positive regulation of interleukin-2 biosynthetic process
0.54	GO:0072540	T-helper 17 cell lineage commitment
0.53	GO:0043011	myeloid dendritic cell differentiation
0.53	GO:0042832	defense response to protozoan
0.53	GO:0034122	negative regulation of toll-like receptor signaling pathway

0.75	GO:0044212	transcription regulatory region DNA binding
0.60	GO:0003700	DNA binding transcription factor activity
0.49	GO:0016279	protein-lysine N-methyltransferase activity
0.48	GO:1990837	sequence-specific double-stranded DNA binding
0.34	GO:0005515	protein binding
0.33	GO:0003735	structural constituent of ribosome

0.60	GO:0005634	nucleus
0.48	GO:0000785	chromatin
0.47	GO:0044815	DNA packaging complex
0.46	GO:0032993	protein-DNA complex
0.45	GO:0070013	intracellular organelle lumen
0.34	GO:0005829	cytosol
0.32	GO:0005840	ribosome
0.30	GO:0016020	membrane

0.49

GO:0016279

tr|T1EHE3|T1EHE3_HELRO
Uncharacterized protein
Search

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.35	GO:0007521	muscle cell fate determination
0.35	GO:0007501	mesodermal cell fate specification
0.34	GO:0007517	muscle organ development
0.33	GO:1902679	negative regulation of RNA biosynthetic process

0.65	GO:0043565	sequence-specific DNA binding
0.34	GO:0004000	adenosine deaminase activity

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.34

GO:0004000

tr|T1EHE4|T1EHE4_HELRO
Uncharacterized protein
Search

0.72	GO:0043401	steroid hormone mediated signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.55	GO:0030522	intracellular receptor signaling pathway
0.40	GO:0007553	regulation of ecdysteroid metabolic process
0.40	GO:0035075	response to ecdysone
0.40	GO:0018990	ecdysis, chitin-based cuticle
0.39	GO:0019730	antimicrobial humoral response

0.70	GO:0003707	steroid hormone receptor activity
0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.39	GO:0005496	steroid binding
0.35	GO:0020037	heme binding
0.33	GO:0004386	helicase activity
0.32	GO:0005515	protein binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.61	GO:0005634	nucleus
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EHE5|T1EHE5_HELRO
Homeobox protein engrailed-like
Search

0.56	Homeobox protein engrailed-1

0.69	GO:0007275	multicellular organism development
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.52	GO:1901215	negative regulation of neuron death
0.52	GO:0043523	regulation of neuron apoptotic process
0.50	GO:0060322	head development
0.50	GO:0043066	negative regulation of apoptotic process
0.49	GO:0051254	positive regulation of RNA metabolic process
0.49	GO:0030154	cell differentiation

0.65	GO:0043565	sequence-specific DNA binding
0.42	GO:0035326	enhancer binding
0.42	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.41	GO:0001012	RNA polymerase II regulatory region DNA binding
0.40	GO:0008094	DNA-dependent ATPase activity
0.39	GO:0003690	double-stranded DNA binding
0.36	GO:0030554	adenyl nucleotide binding
0.36	GO:0097367	carbohydrate derivative binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0008144	drug binding

0.61	GO:0005634	nucleus
0.43	GO:0070013	intracellular organelle lumen
0.40	GO:0043232	intracellular non-membrane-bounded organelle
0.39	GO:0044446	intracellular organelle part
0.34	GO:0030175	filopodium
0.34	GO:0030426	growth cone
0.34	GO:0030027	lamellipodium
0.30	GO:0016020	membrane

tr|T1EHE6|T1EHE6_HELRO
Uncharacterized protein
Search

0.10	Neuroligin-1

0.76	GO:0050808	synapse organization
0.76	GO:0050804	modulation of chemical synaptic transmission
0.68	GO:0007155	cell adhesion
0.58	GO:2000969	positive regulation of AMPA receptor activity
0.58	GO:0061002	negative regulation of dendritic spine morphogenesis
0.58	GO:2000809	positive regulation of synaptic vesicle clustering
0.57	GO:0060080	inhibitory postsynaptic potential
0.57	GO:0002087	regulation of respiratory gaseous exchange by neurological system process
0.57	GO:2000331	regulation of terminal button organization
0.57	GO:2000310	regulation of NMDA receptor activity

0.84	GO:0042043	neurexin family protein binding
0.54	GO:0097110	scaffold protein binding
0.45	GO:0052689	carboxylic ester hydrolase activity
0.42	GO:0004872	receptor activity
0.38	GO:0050839	cell adhesion molecule binding
0.37	GO:0008013	beta-catenin binding
0.37	GO:0001104	RNA polymerase II transcription cofactor activity

0.71	GO:0045202	synapse
0.63	GO:0005887	integral component of plasma membrane
0.52	GO:0009986	cell surface
0.39	GO:0030139	endocytic vesicle
0.38	GO:0098590	plasma membrane region
0.37	GO:0030054	cell junction
0.37	GO:0016592	mediator complex
0.36	GO:0089717	spanning component of membrane
0.35	GO:0043025	neuronal cell body
0.35	GO:0030425	dendrite

0.45	EC:3.1.1 EC:3.1.1.1	GO:0052689
0.45	KEGG:R00630	GO:0052689

tr|T1EHE7|T1EHE7_HELRO
Uncharacterized protein
Search

0.85	Mitochondrial ATP synthase-coupling factor 6

0.70	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.70	GO:0006754	ATP biosynthetic process

0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.34	GO:0016887	ATPase activity

0.78

GO:0000276

mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

0.34

GO:0016887

tr|T1EHE8|T1EHE8_HELRO
Uncharacterized protein
Search

0.11	Rna-directed dna polymerase from mobile element jockey-like protein (Fragment)

0.70	GO:0006278	RNA-dependent DNA biosynthetic process
0.45	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

0.70	GO:0003964	RNA-directed DNA polymerase activity
0.46	GO:0004523	RNA-DNA hybrid ribonuclease activity
0.38	GO:0003676	nucleic acid binding

0.30

GO:0031224

intrinsic component of membrane

0.70

GO:0003964

tr|T1EHE9|T1EHE9_HELRO
Uncharacterized protein
Search

0.70	GO:0007275	multicellular organism development
0.70	GO:0009966	regulation of signal transduction
0.46	GO:0071901	negative regulation of protein serine/threonine kinase activity
0.44	GO:0023057	negative regulation of signaling
0.44	GO:0010648	negative regulation of cell communication
0.43	GO:0090311	regulation of protein deacetylation
0.43	GO:0048585	negative regulation of response to stimulus
0.43	GO:2001022	positive regulation of response to DNA damage stimulus
0.42	GO:0010801	negative regulation of peptidyl-threonine phosphorylation
0.41	GO:0090287	regulation of cellular response to growth factor stimulus

0.49	GO:0005173	stem cell factor receptor binding
0.43	GO:0030291	protein serine/threonine kinase inhibitor activity
0.41	GO:0019901	protein kinase binding
0.37	GO:0019902	phosphatase binding

0.40	GO:0031410	cytoplasmic vesicle
0.38	GO:0005886	plasma membrane
0.35	GO:0005829	cytosol
0.34	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

tr|T1EHF0|T1EHF0_HELRO
Uncharacterized protein
Search

0.74	GO:0043401	steroid hormone mediated signaling pathway
0.62	GO:0030522	intracellular receptor signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.49	GO:0042738	exogenous drug catabolic process
0.47	GO:0046618	drug export
0.45	GO:0042908	xenobiotic transport
0.45	GO:0051254	positive regulation of RNA metabolic process

0.71	GO:0003707	steroid hormone receptor activity
0.65	GO:0043565	sequence-specific DNA binding
0.64	GO:0004879	nuclear receptor activity
0.63	GO:0008270	zinc ion binding
0.47	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.46	GO:0001012	RNA polymerase II regulatory region DNA binding
0.45	GO:0003690	double-stranded DNA binding
0.37	GO:0008144	drug binding
0.37	GO:0046965	retinoid X receptor binding
0.35	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.45	GO:0045111	intermediate filament cytoskeleton
0.43	GO:0070013	intracellular organelle lumen
0.40	GO:0044446	intracellular organelle part
0.36	GO:0005667	transcription factor complex
0.35	GO:0005829	cytosol
0.33	GO:0005694	chromosome
0.30	GO:0016021	integral component of membrane

tr|T1EHF2|T1EHF2_HELRO
Uncharacterized protein
Search

tr|T1EHF3|T1EHF3_HELRO
Uncharacterized protein
Search

tr|T1EHF4|T1EHF4_HELRO
Uncharacterized protein
Search

tr|T1EHF5|T1EHF5_HELRO
Uncharacterized protein
Search

tr|T1EHF6|T1EHF6_HELRO
Uncharacterized protein
Search

0.63	GO:0006468	protein phosphorylation
0.54	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.54	GO:0007143	female meiotic nuclear division
0.52	GO:0051441	positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle
0.50	GO:0000086	G2/M transition of mitotic cell cycle
0.50	GO:0007135	meiosis II
0.47	GO:0051726	regulation of cell cycle
0.45	GO:0018209	peptidyl-serine modification
0.43	GO:2000241	regulation of reproductive process
0.42	GO:0051783	regulation of nuclear division

0.69	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0071889	14-3-3 protein binding
0.41	GO:0051721	protein phosphatase 2A binding
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0048037	cofactor binding

0.50	GO:0097610	cell surface furrow
0.49	GO:0032155	cell division site part
0.47	GO:0005813	centrosome
0.45	GO:0044428	nuclear part
0.43	GO:0031974	membrane-enclosed lumen
0.39	GO:0012505	endomembrane system
0.38	GO:0031967	organelle envelope
0.36	GO:0005737	cytoplasm
0.34	GO:0072687	meiotic spindle
0.33	GO:0030529	intracellular ribonucleoprotein complex

0.69

GO:0004674

tr|T1EHF7|T1EHF7_HELRO
Uncharacterized protein
Search

0.72	GO:0043401	steroid hormone mediated signaling pathway
0.59	GO:0030522	intracellular receptor signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.49	GO:0042738	exogenous drug catabolic process
0.47	GO:0046618	drug export
0.45	GO:0042908	xenobiotic transport
0.45	GO:0051254	positive regulation of RNA metabolic process

0.69	GO:0003707	steroid hormone receptor activity
0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.46	GO:0001012	RNA polymerase II regulatory region DNA binding
0.44	GO:0003690	double-stranded DNA binding
0.37	GO:0008144	drug binding
0.37	GO:0046965	retinoid X receptor binding
0.35	GO:0034191	apolipoprotein A-I receptor binding
0.34	GO:0051117	ATPase binding

0.61	GO:0005634	nucleus
0.45	GO:0045111	intermediate filament cytoskeleton
0.43	GO:0070013	intracellular organelle lumen
0.40	GO:0044446	intracellular organelle part
0.36	GO:0005667	transcription factor complex
0.35	GO:0005829	cytosol
0.33	GO:0005694	chromosome
0.30	GO:0016021	integral component of membrane

tr|T1EHF8|T1EHF8_HELRO
Uncharacterized protein
Search

0.10	Thyroid transcription factor 1 (Fragment)

0.57	GO:0021536	diencephalon development
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0021761	limbic system development
0.56	GO:0010468	regulation of gene expression
0.51	GO:0030878	thyroid gland development
0.51	GO:0060486	Clara cell differentiation
0.51	GO:0010719	negative regulation of epithelial to mesenchymal transition
0.51	GO:0060441	epithelial tube branching involved in lung morphogenesis
0.51	GO:0060510	Type II pneumocyte differentiation

0.64	GO:0043565	sequence-specific DNA binding
0.52	GO:0044213	intronic transcription regulatory region DNA binding
0.48	GO:0001047	core promoter binding
0.48	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.47	GO:0001012	RNA polymerase II regulatory region DNA binding
0.46	GO:0003690	double-stranded DNA binding
0.45	GO:0019899	enzyme binding
0.35	GO:0008134	transcription factor binding
0.34	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.34	GO:0042803	protein homodimerization activity

0.61	GO:0005634	nucleus
0.45	GO:0005667	transcription factor complex
0.37	GO:0070013	intracellular organelle lumen
0.35	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

tr|T1EHF9|T1EHF9_HELRO
Uncharacterized protein
Search

0.96	Iroquois-class homeodomain protein IRX-1 (Fragment)

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.55	GO:0009790	embryo development
0.52	GO:0048731	system development
0.51	GO:0009653	anatomical structure morphogenesis
0.47	GO:1904888	cranial skeletal system development
0.46	GO:0030154	cell differentiation
0.46	GO:0002027	regulation of heart rate
0.46	GO:0045137	development of primary sexual characteristics

0.65	GO:0043565	sequence-specific DNA binding
0.35	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.34	GO:0044212	transcription regulatory region DNA binding
0.34	GO:0005499	vitamin D binding
0.33	GO:0003723	RNA binding
0.33	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EHG0|T1EHG0_HELRO
Uncharacterized protein
Search

LAB

0.58	Labial homeodomain protein (Fragment)

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.46	GO:0035283	central nervous system segmentation
0.46	GO:0090098	positive regulation of decapentaplegic signaling pathway
0.44	GO:0060323	head morphogenesis
0.43	GO:0007420	brain development
0.41	GO:0051254	positive regulation of RNA metabolic process
0.41	GO:0010557	positive regulation of macromolecule biosynthetic process
0.41	GO:0031328	positive regulation of cellular biosynthetic process

0.64	GO:0043565	sequence-specific DNA binding
0.44	GO:0035326	enhancer binding
0.44	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.41	GO:0046982	protein heterodimerization activity
0.34	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.34	GO:0004000	adenosine deaminase activity
0.34	GO:0001012	RNA polymerase II regulatory region DNA binding
0.34	GO:0019904	protein domain specific binding
0.33	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part

0.34

GO:0004000

tr|T1EHG1|T1EHG1_HELRO
Uncharacterized protein
Search

0.10	Krueppel-like factor 8

0.45	GO:0045893	positive regulation of transcription, DNA-templated
0.45	GO:0006366	transcription by RNA polymerase II
0.45	GO:0006357	regulation of transcription by RNA polymerase II
0.40	GO:0021634	optic nerve formation
0.39	GO:0043249	erythrocyte maturation
0.39	GO:0045892	negative regulation of transcription, DNA-templated
0.38	GO:0035265	organ growth
0.38	GO:0031016	pancreas development
0.38	GO:0001889	liver development
0.38	GO:1901654	response to ketone

0.51	GO:0003676	nucleic acid binding
0.47	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.40	GO:0003682	chromatin binding
0.38	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.35	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.47	GO:0001650	fibrillar center
0.43	GO:0005829	cytosol
0.38	GO:0005700	polytene chromosome
0.36	GO:0000785	chromatin
0.32	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1EHG2|T1EHG2_HELRO
Uncharacterized protein
Search

0.71	DNA-binding protein D-ETS-4

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.52	GO:0060480	lung goblet cell differentiation
0.51	GO:0060576	intestinal epithelial cell development
0.51	GO:0010455	positive regulation of cell fate commitment
0.50	GO:0010454	negative regulation of cell fate commitment
0.48	GO:0043065	positive regulation of apoptotic process
0.45	GO:1902680	positive regulation of RNA biosynthetic process
0.45	GO:1902679	negative regulation of RNA biosynthetic process

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity

0.61

GO:0005634

nucleus

tr|T1EHG3|T1EHG3_HELRO
Uncharacterized protein
Search

0.10	Carboxylic ester hydrolase (Fragment)

0.43	GO:0006629	lipid metabolic process
0.38	GO:0097105	presynaptic membrane assembly
0.38	GO:0097104	postsynaptic membrane assembly
0.38	GO:0007158	neuron cell-cell adhesion
0.37	GO:0048488	synaptic vesicle endocytosis
0.37	GO:0044248	cellular catabolic process
0.37	GO:0050804	modulation of chemical synaptic transmission
0.37	GO:0043603	cellular amide metabolic process
0.36	GO:1901565	organonitrogen compound catabolic process
0.35	GO:0030299	intestinal cholesterol absorption

0.46	GO:0016787	hydrolase activity
0.37	GO:0042043	neurexin family protein binding
0.35	GO:0004872	receptor activity
0.35	GO:0003735	structural constituent of ribosome
0.33	GO:0008201	heparin binding
0.33	GO:0005230	extracellular ligand-gated ion channel activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0008144	drug binding

0.37	GO:0034719	SMN-Sm protein complex
0.36	GO:0009986	cell surface
0.36	GO:0045202	synapse
0.35	GO:0005887	integral component of plasma membrane
0.34	GO:0005840	ribosome
0.33	GO:0070062	extracellular exosome
0.33	GO:0005794	Golgi apparatus
0.33	GO:0005783	endoplasmic reticulum

0.46

GO:0016787

tr|T1EHG4|T1EHG4_HELRO
Uncharacterized protein
Search

0.30

GO:0008152

metabolic process

0.53

GO:0004104

cholinesterase activity

0.30

GO:0044425

membrane part

0.53

GO:0004104

tr|T1EHG5|T1EHG5_HELRO
Uncharacterized protein
Search

tr|T1EHG6|T1EHG6_HELRO
Uncharacterized protein
Search

0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:0003327	type B pancreatic cell fate commitment
0.53	GO:0060580	ventral spinal cord interneuron fate determination
0.53	GO:0021530	spinal cord oligodendrocyte cell fate specification
0.53	GO:0003326	pancreatic A cell fate commitment
0.53	GO:0003329	pancreatic PP cell fate commitment
0.51	GO:0048714	positive regulation of oligodendrocyte differentiation
0.51	GO:0003323	type B pancreatic cell development

0.64	GO:0043565	sequence-specific DNA binding
0.47	GO:0003713	transcription coactivator activity
0.47	GO:0044212	transcription regulatory region DNA binding
0.47	GO:0003682	chromatin binding
0.45	GO:0003690	double-stranded DNA binding
0.45	GO:0008134	transcription factor binding
0.42	GO:0003700	DNA binding transcription factor activity
0.34	GO:0004000	adenosine deaminase activity

0.61	GO:0005634	nucleus
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part

0.34

GO:0004000

tr|T1EHG7|T1EHG7_HELRO
Uncharacterized protein
Search

0.97	Homeodmain protein (Fragment)

0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.53	GO:0060526	prostate glandular acinus morphogenesis
0.53	GO:0060687	regulation of branching involved in prostate gland morphogenesis
0.52	GO:0060442	branching involved in prostate gland morphogenesis
0.52	GO:0060602	branch elongation of an epithelium
0.52	GO:0060571	morphogenesis of an epithelial fold
0.51	GO:0030539	male genitalia development
0.51	GO:0042733	embryonic digit morphogenesis

0.63	GO:0043565	sequence-specific DNA binding
0.50	GO:0035326	enhancer binding
0.49	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.48	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.48	GO:0001012	RNA polymerase II regulatory region DNA binding
0.47	GO:0003682	chromatin binding
0.45	GO:0003690	double-stranded DNA binding
0.40	GO:0008289	lipid binding

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EHG8|T1EHG8_HELRO
Uncharacterized protein
Search

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.42	GO:0060756	foraging behavior
0.42	GO:0061038	uterus morphogenesis
0.42	GO:0030421	defecation
0.40	GO:0030182	neuron differentiation
0.39	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.39	GO:0000904	cell morphogenesis involved in differentiation
0.39	GO:0120036	plasma membrane bounded cell projection organization

0.63	GO:0043565	sequence-specific DNA binding
0.51	GO:0046872	metal ion binding
0.34	GO:0003700	DNA binding transcription factor activity
0.33	GO:0030246	carbohydrate binding
0.32	GO:0016740	transferase activity

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.32

GO:0016740

tr|T1EHG9|T1EHG9_HELRO
Uncharacterized protein
Search

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.41	GO:0060756	foraging behavior
0.40	GO:0061038	uterus morphogenesis
0.40	GO:0030421	defecation
0.39	GO:0030182	neuron differentiation
0.38	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.38	GO:0000904	cell morphogenesis involved in differentiation
0.38	GO:0120036	plasma membrane bounded cell projection organization

0.63	GO:0043565	sequence-specific DNA binding
0.51	GO:0046872	metal ion binding
0.34	GO:0003700	DNA binding transcription factor activity
0.33	GO:0030246	carbohydrate binding

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EHH0|T1EHH0_HELRO
Uncharacterized protein
Search

0.57	Putative ccaat enhancer binding protein (C ebp) gamma (Fragment)

0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:0010468	regulation of gene expression

0.61

GO:0003700

DNA binding transcription factor activity

tr|T1EHH1|T1EHH1_HELRO
Uncharacterized protein
Search

0.40	Tetratricopeptide repeat protein (Fragment)

0.77	GO:0051085	chaperone cofactor-dependent protein refolding
0.41	GO:0009408	response to heat
0.40	GO:1900034	regulation of cellular response to heat
0.39	GO:0032781	positive regulation of ATPase activity
0.39	GO:0006260	DNA replication

0.74	GO:0031072	heat shock protein binding
0.47	GO:0051082	unfolded protein binding
0.39	GO:0001671	ATPase activator activity
0.38	GO:0008270	zinc ion binding
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003677	DNA binding

0.64	GO:0005654	nucleoplasm
0.63	GO:0005829	cytosol
0.47	GO:0070062	extracellular exosome
0.40	GO:0005856	cytoskeleton
0.35	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

tr|T1EHH2|T1EHH2_HELRO
Uncharacterized protein
Search

0.67	GO:0006886	intracellular protein transport
0.57	GO:0006887	exocytosis
0.40	GO:0048489	synaptic vesicle transport
0.40	GO:0099504	synaptic vesicle cycle
0.40	GO:0099643	signal release from synapse
0.40	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.40	GO:0050804	modulation of chemical synaptic transmission
0.40	GO:0030421	defecation
0.40	GO:0043051	regulation of pharyngeal pumping
0.39	GO:0048639	positive regulation of developmental growth

0.78	GO:0017137	Rab GTPase binding
0.51	GO:0046872	metal ion binding
0.38	GO:0008022	protein C-terminus binding
0.36	GO:0044325	ion channel binding

0.60	GO:0048786	presynaptic active zone
0.44	GO:0005622	intracellular
0.38	GO:0030424	axon
0.34	GO:0030054	cell junction
0.30	GO:0016020	membrane

tr|T1EHH3|T1EHH3_HELRO
Uncharacterized protein
Search

0.74	GO:0043401	steroid hormone mediated signaling pathway
0.61	GO:0030522	intracellular receptor signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.49	GO:0042738	exogenous drug catabolic process
0.47	GO:0046618	drug export
0.45	GO:0042908	xenobiotic transport
0.45	GO:0051254	positive regulation of RNA metabolic process

0.70	GO:0003707	steroid hormone receptor activity
0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.63	GO:0004879	nuclear receptor activity
0.47	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.47	GO:0001012	RNA polymerase II regulatory region DNA binding
0.45	GO:0003690	double-stranded DNA binding
0.38	GO:0008144	drug binding
0.37	GO:0046965	retinoid X receptor binding
0.35	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.45	GO:0045111	intermediate filament cytoskeleton
0.43	GO:0070013	intracellular organelle lumen
0.40	GO:0044446	intracellular organelle part
0.36	GO:0005667	transcription factor complex
0.35	GO:0005829	cytosol
0.33	GO:0005694	chromosome
0.30	GO:0016021	integral component of membrane

tr|T1EHH4|T1EHH4_HELRO
Uncharacterized protein
Search

tr|T1EHH5|T1EHH5_HELRO
Uncharacterized protein
Search

POST2

0.66	Hox class homeodomain-containing protein Post2 (Fragment)

0.59	GO:0007275	multicellular organism development
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.46	GO:0048857	neural nucleus development
0.46	GO:0048532	anatomical structure arrangement
0.46	GO:0002011	morphogenesis of an epithelial sheet
0.44	GO:0060322	head development
0.42	GO:1902680	positive regulation of RNA biosynthetic process
0.34	GO:0006351	transcription, DNA-templated

0.65	GO:0043565	sequence-specific DNA binding
0.53	GO:0003700	DNA binding transcription factor activity

0.61	GO:0005634	nucleus
0.41	GO:0005829	cytosol
0.40	GO:0043233	organelle lumen
0.38	GO:0044446	intracellular organelle part

tr|T1EHH6|T1EHH6_HELRO
Uncharacterized protein
Search

0.41	GO:1903506	regulation of nucleic acid-templated transcription
0.41	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.41	GO:0010468	regulation of gene expression
0.41	GO:0040034	regulation of development, heterochronic
0.36	GO:1902679	negative regulation of RNA biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.41	GO:0046872	metal ion binding
0.39	GO:0003700	DNA binding transcription factor activity
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0019001	guanyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.37	GO:0005634	nucleus
0.35	GO:0012505	endomembrane system
0.34	GO:0031967	organelle envelope
0.34	GO:0031090	organelle membrane

tr|T1EHH7|T1EHH7_HELRO
Uncharacterized protein
Search

SNRPE

0.83	Small nuclear ribonucleoprotein polypeptide E

0.75	GO:0000398	mRNA splicing, via spliceosome
0.45	GO:0022618	ribonucleoprotein complex assembly
0.42	GO:0042633	hair cycle
0.35	GO:0008334	histone mRNA metabolic process
0.34	GO:0006369	termination of RNA polymerase II transcription
0.34	GO:0051170	nuclear import
0.34	GO:0016255	attachment of GPI anchor to protein
0.33	GO:0070588	calcium ion transmembrane transport
0.33	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.33	GO:2001141	regulation of RNA biosynthetic process

0.36	GO:0003723	RNA binding
0.35	GO:1990446	U1 snRNP binding
0.34	GO:0003923	GPI-anchor transamidase activity
0.34	GO:0005388	calcium-transporting ATPase activity
0.33	GO:0005515	protein binding
0.33	GO:0043565	sequence-specific DNA binding
0.32	GO:0008233	peptidase activity
0.32	GO:0003700	DNA binding transcription factor activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.76	GO:0005681	spliceosomal complex
0.57	GO:0019013	viral nucleocapsid
0.50	GO:0005687	U4 snRNP
0.48	GO:0005685	U1 snRNP
0.48	GO:0005682	U5 snRNP
0.47	GO:0005686	U2 snRNP
0.47	GO:0046540	U4/U6 x U5 tri-snRNP complex
0.44	GO:0034709	methylosome
0.44	GO:0034715	pICln-Sm protein complex
0.44	GO:0034719	SMN-Sm protein complex

0.34

GO:0003923

tr|T1EHH8|T1EHH8_HELRO
Uncharacterized protein
Search

0.37	GO:0050808	synapse organization
0.37	GO:0050804	modulation of chemical synaptic transmission
0.36	GO:0007155	cell adhesion
0.35	GO:0048488	synaptic vesicle endocytosis
0.34	GO:0071709	membrane assembly
0.34	GO:0007399	nervous system development
0.33	GO:0055085	transmembrane transport
0.30	GO:0008152	metabolic process

0.61	GO:0042043	neurexin family protein binding
0.46	GO:0016787	hydrolase activity
0.34	GO:0015399	primary active transmembrane transporter activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0004872	receptor activity
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.37	GO:0045202	synapse
0.35	GO:0005887	integral component of plasma membrane
0.34	GO:0009986	cell surface

0.46

GO:0016787

tr|T1EHH9|T1EHH9_HELRO
Uncharacterized protein
Search

0.55	Erythroid Kruppel-like factor 1 variant (Fragment)

0.46	GO:1903861	positive regulation of dendrite extension
0.46	GO:0050775	positive regulation of dendrite morphogenesis
0.45	GO:0007026	negative regulation of microtubule depolymerization
0.44	GO:0045944	positive regulation of transcription by RNA polymerase II
0.43	GO:0000122	negative regulation of transcription by RNA polymerase II
0.39	GO:0048813	dendrite morphogenesis
0.38	GO:0007411	axon guidance
0.37	GO:0006366	transcription by RNA polymerase II
0.33	GO:0006629	lipid metabolic process

0.51	GO:0003676	nucleic acid binding
0.38	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.33	GO:0052689	carboxylic ester hydrolase activity
0.32	GO:0046872	metal ion binding

0.39	GO:0005634	nucleus
0.33	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.33	EC:3.1.1 EC:3.1.1.1	GO:0052689
0.33	KEGG:R00630	GO:0052689

tr|T1EHI0|T1EHI0_HELRO
Uncharacterized protein
Search

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:0061011	hepatic duct development
0.53	GO:0060431	primary lung bud formation
0.53	GO:0061017	hepatoblast differentiation
0.53	GO:0061010	gall bladder development
0.52	GO:0022027	interkinetic nuclear migration
0.52	GO:0070365	hepatocyte differentiation
0.52	GO:0090009	primitive streak formation

0.65	GO:0043565	sequence-specific DNA binding
0.52	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.51	GO:0071837	HMG box domain binding
0.51	GO:0008190	eukaryotic initiation factor 4E binding
0.50	GO:0008301	DNA binding, bending
0.50	GO:0070491	repressing transcription factor binding
0.50	GO:0044212	transcription regulatory region DNA binding
0.48	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.48	GO:0003682	chromatin binding
0.47	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.45	GO:0032993	protein-DNA complex
0.38	GO:0005737	cytoplasm
0.37	GO:0042995	cell projection
0.34	GO:0097458	neuron part
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016020	membrane

tr|T1EHI1|T1EHI1_HELRO
Uncharacterized protein
Search

0.10	Voltage-dependent T-type calcium channel subunit alpha-1H (Fragment)

0.70	GO:0070588	calcium ion transmembrane transport
0.54	GO:0034765	regulation of ion transmembrane transport
0.45	GO:0070509	calcium ion import
0.38	GO:0019228	neuronal action potential
0.38	GO:0086010	membrane depolarization during action potential
0.37	GO:0035725	sodium ion transmembrane transport
0.36	GO:0030488	tRNA methylation

0.75	GO:0005245	voltage-gated calcium channel activity
0.38	GO:0005248	voltage-gated sodium channel activity
0.37	GO:0016428	tRNA (cytosine-5-)-methyltransferase activity
0.34	GO:0003723	RNA binding

0.73	GO:0005891	voltage-gated calcium channel complex
0.33	GO:0005887	integral component of plasma membrane

0.37

GO:0016428

tr|T1EHI2|T1EHI2_HELRO
Uncharacterized protein
Search

0.95	NK protein (Fragment)

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.35	GO:0007521	muscle cell fate determination
0.35	GO:0007501	mesodermal cell fate specification
0.34	GO:0007517	muscle organ development
0.33	GO:1902679	negative regulation of RNA biosynthetic process

0.65	GO:0043565	sequence-specific DNA binding
0.34	GO:0004000	adenosine deaminase activity

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.34

GO:0004000

tr|T1EHI3|T1EHI3_HELRO
Uncharacterized protein
Search

0.64	Tyramine/octopamine receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.54	GO:0007210	serotonin receptor signaling pathway
0.53	GO:0006939	smooth muscle contraction
0.53	GO:0042310	vasoconstriction
0.52	GO:0007623	circadian rhythm
0.51	GO:0007268	chemical synaptic transmission
0.45	GO:0019933	cAMP-mediated signaling
0.42	GO:0045887	positive regulation of synaptic growth at neuromuscular junction
0.42	GO:0030728	ovulation
0.41	GO:0009566	fertilization

0.72	GO:0004930	G-protein coupled receptor activity
0.61	GO:0030594	neurotransmitter receptor activity
0.54	GO:0099589	serotonin receptor activity
0.38	GO:0001653	peptide receptor activity
0.37	GO:0051380	norepinephrine binding
0.37	GO:0051379	epinephrine binding
0.37	GO:0035240	dopamine binding
0.36	GO:0017124	SH3 domain binding
0.35	GO:0042802	identical protein binding
0.35	GO:0003700	DNA binding transcription factor activity

0.48	GO:0005887	integral component of plasma membrane
0.36	GO:0098794	postsynapse
0.34	GO:0005622	intracellular

0.35

GO:0004715

tr|T1EHI4|T1EHI4_HELRO
Uncharacterized protein
Search

0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.47	GO:0021984	adenohypophysis development
0.47	GO:0048850	hypophysis morphogenesis
0.46	GO:0021979	hypothalamus cell differentiation
0.44	GO:0006366	transcription by RNA polymerase II
0.44	GO:0060070	canonical Wnt signaling pathway
0.44	GO:0009953	dorsal/ventral pattern formation
0.44	GO:0045935	positive regulation of nucleobase-containing compound metabolic process

0.63	GO:0043565	sequence-specific DNA binding
0.46	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
0.46	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
0.45	GO:0001012	RNA polymerase II regulatory region DNA binding
0.45	GO:0035326	enhancer binding
0.44	GO:0008013	beta-catenin binding
0.44	GO:0008022	protein C-terminus binding
0.43	GO:0003690	double-stranded DNA binding
0.43	GO:0003682	chromatin binding
0.38	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.42	GO:0005667	transcription factor complex
0.36	GO:0005829	cytosol
0.33	GO:0000785	chromatin
0.33	GO:0070013	intracellular organelle lumen
0.30	GO:0016020	membrane

0.34

GO:0004000

tr|T1EHI5|T1EHI5_HELRO
Uncharacterized protein
Search

0.59	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.57	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.57	GO:0031398	positive regulation of protein ubiquitination
0.41	GO:0051865	protein autoubiquitination
0.37	GO:0070987	error-free translesion synthesis
0.37	GO:0045471	response to ethanol
0.37	GO:0000921	septin ring assembly
0.36	GO:0036297	interstrand cross-link repair
0.36	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

0.60	GO:0008270	zinc ion binding
0.59	GO:0002039	p53 binding
0.54	GO:0004842	ubiquitin-protein transferase activity
0.54	GO:0042803	protein homodimerization activity
0.38	GO:0005102	receptor binding
0.36	GO:0061659	ubiquitin-like protein ligase activity
0.34	GO:0004386	helicase activity
0.34	GO:0003723	RNA binding
0.34	GO:0016874	ligase activity
0.33	GO:0005524	ATP binding

0.54	GO:0000151	ubiquitin ligase complex
0.51	GO:0005654	nucleoplasm
0.50	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.34	EC:6	GO:0016874
0.54	KEGG:R03876	GO:0004842

tr|T1EHI6|T1EHI6_HELRO
Uncharacterized protein
Search

0.60	GO:0030433	ubiquitin-dependent ERAD pathway
0.56	GO:0016567	protein ubiquitination
0.40	GO:0036297	interstrand cross-link repair
0.39	GO:0007034	vacuolar transport
0.38	GO:1904380	endoplasmic reticulum mannose trimming
0.36	GO:0007417	central nervous system development

0.57	GO:0004842	ubiquitin-protein transferase activity
0.45	GO:0016874	ligase activity
0.39	GO:0046872	metal ion binding
0.39	GO:0061659	ubiquitin-like protein ligase activity
0.36	GO:0035091	phosphatidylinositol binding
0.35	GO:0030976	thiamine pyrophosphate binding
0.34	GO:0005515	protein binding
0.34	GO:0004386	helicase activity
0.33	GO:0005524	ATP binding

0.53	GO:0005783	endoplasmic reticulum
0.39	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.38	GO:0031984	organelle subcompartment
0.36	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.45	EC:6	GO:0016874
0.57	KEGG:R03876	GO:0004842

tr|T1EHI7|T1EHI7_HELRO
Uncharacterized protein
Search

POLE4

0.68	DNA polymerase epsilon subunit 4

0.74	GO:0046982	protein heterodimerization activity
0.36	GO:0003677	DNA binding

0.58

GO:0005634

nucleus

tr|T1EHI8|T1EHI8_HELRO
Uncharacterized protein
Search

0.40	Putative syntaxin-binding protein 2 (Fragment)

0.37	GO:0070647	protein modification by small protein conjugation or removal
0.35	GO:0007165	signal transduction
0.35	GO:0042073	intraciliary transport
0.35	GO:0006270	DNA replication initiation
0.34	GO:0060271	cilium assembly
0.34	GO:0009190	cyclic nucleotide biosynthetic process
0.34	GO:0006508	proteolysis
0.34	GO:1990823	response to leukemia inhibitory factor
0.34	GO:0043966	histone H3 acetylation
0.33	GO:0060078	regulation of postsynaptic membrane potential

0.36	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.35	GO:0032403	protein complex binding
0.35	GO:0004842	ubiquitin-protein transferase activity
0.35	GO:0004871	signal transducer activity
0.34	GO:0016849	phosphorus-oxygen lyase activity
0.34	GO:0003677	DNA binding
0.34	GO:0015631	tubulin binding
0.34	GO:0099600	transmembrane receptor activity
0.34	GO:0003924	GTPase activity
0.34	GO:0019001	guanyl nucleotide binding

0.35	GO:0030992	intraciliary transport particle B
0.34	GO:0031514	motile cilium
0.34	GO:0070776	MOZ/MORF histone acetyltransferase complex
0.33	GO:0045211	postsynaptic membrane
0.33	GO:0030054	cell junction
0.33	GO:0000786	nucleosome
0.30	GO:0016021	integral component of membrane

0.34	EC:4.6	GO:0016849
0.35	KEGG:R03876	GO:0004842

tr|T1EHI9|T1EHI9_HELRO
Uncharacterized protein
Search

0.90	Iroquois-class homeodomain protein IRX-4 (Fragment)

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.48	GO:0009954	proximal/distal pattern formation
0.46	GO:0061004	pattern specification involved in kidney development
0.46	GO:0072070	loop of Henle development
0.46	GO:0072079	nephron tubule formation
0.45	GO:0007379	segment specification
0.45	GO:0001656	metanephros development
0.43	GO:0045665	negative regulation of neuron differentiation

0.65	GO:0043565	sequence-specific DNA binding
0.39	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.36	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.39	GO:0030424	axon
0.33	GO:0005737	cytoplasm

tr|T1EHJ0|T1EHJ0_HELRO
Uncharacterized protein
Search

0.84	Transcriptional regulator Erg (Fragment)

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.47	GO:0048665	neuron fate specification
0.47	GO:0042551	neuron maturation
0.43	GO:0010604	positive regulation of macromolecule metabolic process
0.37	GO:0071542	dopaminergic neuron differentiation
0.37	GO:0045935	positive regulation of nucleobase-containing compound metabolic process
0.37	GO:0031328	positive regulation of cellular biosynthetic process
0.36	GO:0006366	transcription by RNA polymerase II

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.36	GO:0044212	transcription regulatory region DNA binding
0.35	GO:0003690	double-stranded DNA binding
0.34	GO:0005509	calcium ion binding
0.34	GO:0003714	transcription corepressor activity
0.34	GO:0140096	catalytic activity, acting on a protein
0.34	GO:0003682	chromatin binding
0.33	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.33	GO:0016301	kinase activity

0.61	GO:0005634	nucleus
0.41	GO:0043233	organelle lumen
0.38	GO:0044446	intracellular organelle part
0.34	GO:0043025	neuronal cell body
0.34	GO:0019773	proteasome core complex, alpha-subunit complex
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.33

GO:0016773

tr|T1EHJ1|T1EHJ1_HELRO
Uncharacterized protein
Search

0.76	GO:0007163	establishment or maintenance of cell polarity
0.49	GO:0045216	cell-cell junction organization
0.46	GO:0034329	cell junction assembly
0.45	GO:0007430	terminal branching, open tracheal system
0.45	GO:0010592	positive regulation of lamellipodium assembly
0.45	GO:0055059	asymmetric neuroblast division
0.44	GO:0051491	positive regulation of filopodium assembly
0.44	GO:0001933	negative regulation of protein phosphorylation
0.44	GO:0007298	border follicle cell migration
0.44	GO:0007416	synapse assembly

0.42	GO:0030742	GTP-dependent protein binding
0.41	GO:0005080	protein kinase C binding
0.39	GO:0017048	Rho GTPase binding
0.34	GO:0005509	calcium ion binding
0.33	GO:0016780	phosphotransferase activity, for other substituted phosphate groups
0.33	GO:0004252	serine-type endopeptidase activity

0.46	GO:0016324	apical plasma membrane
0.45	GO:0097482	muscle cell postsynaptic specialization
0.44	GO:0005938	cell cortex
0.44	GO:0043195	terminal bouton
0.42	GO:0034451	centriolar satellite
0.41	GO:0043296	apical junction complex
0.40	GO:0070160	occluding junction
0.36	GO:0005634	nucleus
0.36	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

0.33

GO:0016780

tr|T1EHJ2|T1EHJ2_HELRO
Uncharacterized protein
Search

tr|T1EHJ3|T1EHJ3_HELRO
Uncharacterized protein
Search

tr|T1EHJ4|T1EHJ4_HELRO
Uncharacterized protein
Search

tr|T1EHJ5|T1EHJ5_HELRO
Uncharacterized protein
Search

SPCS1

0.94	Signal peptidase complex subunit 1

0.80	GO:0006465	signal peptide processing
0.45	GO:0045047	protein targeting to ER
0.35	GO:1902358	sulfate transmembrane transport

0.61	GO:0008233	peptidase activity
0.46	GO:0043022	ribosome binding
0.35	GO:0008271	secondary active sulfate transmembrane transporter activity
0.33	GO:0005515	protein binding

0.82	GO:0005787	signal peptidase complex
0.45	GO:0030176	integral component of endoplasmic reticulum membrane
0.35	GO:0031090	organelle membrane

0.61

GO:0008233

tr|T1EHJ6|T1EHJ6_HELRO
Uncharacterized protein
Search

tr|T1EHJ8|T1EHJ8_HELRO
Uncharacterized protein
Search

0.55	GO:0071712	ER-associated misfolded protein catabolic process
0.54	GO:2000785	regulation of autophagosome assembly
0.54	GO:0031648	protein destabilization
0.54	GO:0070534	protein K63-linked ubiquitination
0.54	GO:0070936	protein K48-linked ubiquitination
0.50	GO:0009617	response to bacterium
0.49	GO:0010507	negative regulation of autophagy
0.46	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.46	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.36	GO:1904380	endoplasmic reticulum mannose trimming

0.50	GO:0004842	ubiquitin-protein transferase activity
0.48	GO:0042802	identical protein binding
0.47	GO:0044390	ubiquitin-like protein conjugating enzyme binding
0.46	GO:0061659	ubiquitin-like protein ligase activity
0.43	GO:0016874	ligase activity
0.39	GO:0046872	metal ion binding
0.36	GO:0004540	ribonuclease activity
0.34	GO:0003723	RNA binding

0.56	GO:0036513	Derlin-1 retrotranslocation complex
0.36	GO:0044322	endoplasmic reticulum quality control compartment
0.35	GO:0031966	mitochondrial membrane
0.30	GO:0016021	integral component of membrane

0.43	EC:6	GO:0016874
0.50	KEGG:R03876	GO:0004842

tr|T1EHJ9|T1EHJ9_HELRO
Uncharacterized protein
Search

0.59	GO:0007165	signal transduction
0.39	GO:0006508	proteolysis
0.38	GO:0048790	maintenance of presynaptic active zone structure
0.38	GO:0048789	cytoskeletal matrix organization at active zone
0.38	GO:0045467	R7 cell development
0.38	GO:0051640	organelle localization
0.38	GO:1902284	neuron projection extension involved in neuron projection guidance
0.37	GO:0048675	axon extension
0.37	GO:0009949	polarity specification of anterior/posterior axis
0.36	GO:0007411	axon guidance

0.41	GO:0004252	serine-type endopeptidase activity
0.37	GO:0005080	protein kinase C binding
0.35	GO:0017048	Rho GTPase binding
0.34	GO:0004672	protein kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.37	GO:0048786	presynaptic active zone
0.35	GO:0005938	cell cortex
0.30	GO:0016020	membrane

0.41

GO:0004252

tr|T1EHK0|T1EHK0_HELRO
Uncharacterized protein
Search

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.49	GO:0007567	parturition
0.47	GO:0009790	embryo development
0.46	GO:0007626	locomotory behavior
0.43	GO:0009653	anatomical structure morphogenesis
0.41	GO:0048477	oogenesis
0.36	GO:0006351	transcription, DNA-templated

0.64	GO:0043565	sequence-specific DNA binding
0.35	GO:0003700	DNA binding transcription factor activity

0.61

GO:0005634

nucleus

tr|T1EHK1|T1EHK1_HELRO
Uncharacterized protein
Search

tr|T1EHK2|T1EHK2_HELRO
Uncharacterized protein
Search

tr|T1EHK3|T1EHK3_HELRO
Uncharacterized protein
Search

KXD1

0.73	KxDL motif-containing protein 1 (Fragment)

0.70	GO:0032418	lysosome localization
0.60	GO:0016192	vesicle-mediated transport
0.44	GO:0043043	peptide biosynthetic process
0.42	GO:0044267	cellular protein metabolic process
0.41	GO:0010467	gene expression
0.41	GO:0009059	macromolecule biosynthetic process
0.36	GO:0045892	negative regulation of transcription, DNA-templated
0.36	GO:0055085	transmembrane transport
0.36	GO:0006812	cation transport

0.46	GO:0003735	structural constituent of ribosome
0.38	GO:0005515	protein binding
0.38	GO:0003714	transcription corepressor activity
0.36	GO:0003723	RNA binding
0.36	GO:0008324	cation transmembrane transporter activity
0.35	GO:0003700	DNA binding transcription factor activity

0.73	GO:0099078	BORC complex
0.72	GO:0031083	BLOC-1 complex
0.49	GO:0005765	lysosomal membrane
0.45	GO:0005840	ribosome
0.39	GO:0032021	NELF complex
0.30	GO:0016021	integral component of membrane

tr|T1EHK4|T1EHK4_HELRO
Uncharacterized protein
Search

0.75	GO:1902358	sulfate transmembrane transport
0.54	GO:0015701	bicarbonate transport
0.50	GO:0006821	chloride transport
0.46	GO:0051453	regulation of intracellular pH
0.45	GO:0007605	sensory perception of sound
0.45	GO:0045852	pH elevation
0.44	GO:0019532	oxalate transport
0.43	GO:0042391	regulation of membrane potential
0.40	GO:0048240	sperm capacitation
0.40	GO:0071320	cellular response to cAMP

0.78	GO:0008271	secondary active sulfate transmembrane transporter activity
0.54	GO:0015301	anion:anion antiporter activity
0.46	GO:0015106	bicarbonate transmembrane transporter activity
0.44	GO:0019531	oxalate transmembrane transporter activity
0.42	GO:0015108	chloride transmembrane transporter activity
0.41	GO:0005253	anion channel activity
0.35	GO:0015296	anion:cation symporter activity
0.35	GO:0015081	sodium ion transmembrane transporter activity
0.32	GO:0003700	DNA binding transcription factor activity

0.46	GO:0005887	integral component of plasma membrane
0.40	GO:0097225	sperm midpiece
0.36	GO:0016323	basolateral plasma membrane
0.34	GO:0031526	brush border membrane
0.33	GO:0016324	apical plasma membrane
0.32	GO:0005737	cytoplasm

tr|T1EHK5|T1EHK5_HELRO
Uncharacterized protein
Search

0.78	GO:0006030	chitin metabolic process
0.46	GO:0005975	carbohydrate metabolic process

0.77	GO:0008061	chitin binding
0.50	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds

0.66	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.50

GO:0004553

tr|T1EHK6|T1EHK6_HELRO
Uncharacterized protein
Search

0.90	Chorion b-ZIP transcription factor (Fragment)

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.44	GO:0006366	transcription by RNA polymerase II
0.43	GO:0007623	circadian rhythm
0.41	GO:0006955	immune response
0.39	GO:0032502	developmental process
0.38	GO:1902680	positive regulation of RNA biosynthetic process
0.38	GO:0032501	multicellular organismal process
0.35	GO:0040015	negative regulation of multicellular organism growth

0.61	GO:0003700	DNA binding transcription factor activity
0.40	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.35	GO:0001158	enhancer sequence-specific DNA binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.41

GO:0005634

nucleus

tr|T1EHK7|T1EHK7_HELRO
Uncharacterized protein
Search

0.70	5-hydroxytryptamine receptor 1A (Fragment)

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.66	GO:0007210	serotonin receptor signaling pathway
0.63	GO:0042310	vasoconstriction
0.62	GO:0050795	regulation of behavior
0.61	GO:0046883	regulation of hormone secretion
0.60	GO:0008283	cell proliferation
0.55	GO:0014062	regulation of serotonin secretion
0.54	GO:0042053	regulation of dopamine metabolic process
0.53	GO:0042428	serotonin metabolic process
0.53	GO:0035640	exploration behavior

0.72	GO:0004930	G-protein coupled receptor activity
0.66	GO:0099589	serotonin receptor activity
0.65	GO:0030594	neurotransmitter receptor activity
0.54	GO:0090722	receptor-receptor interaction
0.47	GO:0051378	serotonin binding
0.35	GO:0035240	dopamine binding
0.34	GO:0001965	G-protein alpha-subunit binding

0.57	GO:0005887	integral component of plasma membrane
0.35	GO:0043203	axon hillock
0.34	GO:0030672	synaptic vesicle membrane
0.34	GO:0031526	brush border membrane
0.34	GO:0060170	ciliary membrane
0.33	GO:0097730	non-motile cilium

tr|T1EHK8|T1EHK8_HELRO
Uncharacterized protein
Search

0.50	Zinc finger protein 39 (Fragment)

0.39	GO:0006357	regulation of transcription by RNA polymerase II
0.35	GO:0007283	spermatogenesis
0.34	GO:0030154	cell differentiation
0.34	GO:0007275	multicellular organism development
0.33	GO:0030042	actin filament depolymerization
0.33	GO:0006351	transcription, DNA-templated

0.51	GO:0003676	nucleic acid binding
0.40	GO:0008134	transcription factor binding
0.37	GO:0003700	DNA binding transcription factor activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003779	actin binding
0.33	GO:0046872	metal ion binding

0.56	GO:0005634	nucleus
0.41	GO:0031974	membrane-enclosed lumen
0.40	GO:0005667	transcription factor complex
0.40	GO:1902494	catalytic complex
0.39	GO:0044446	intracellular organelle part
0.33	GO:0015629	actin cytoskeleton
0.30	GO:0016020	membrane

tr|T1EHK9|T1EHK9_HELRO
Uncharacterized protein
Search

0.84	Protein phosphatase 2A regulatory B subunit (Fragment)

0.79	GO:0043666	regulation of phosphoprotein phosphatase activity
0.61	GO:0007165	signal transduction
0.39	GO:1903863	P granule assembly
0.37	GO:0070328	triglyceride homeostasis
0.37	GO:0007274	neuromuscular synaptic transmission
0.37	GO:0007528	neuromuscular junction development
0.37	GO:0097479	synaptic vesicle localization
0.36	GO:0006914	autophagy
0.33	GO:0006099	tricarboxylic acid cycle

0.80	GO:0019888	protein phosphatase regulator activity
0.33	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity
0.33	GO:0030976	thiamine pyrophosphate binding
0.33	GO:0005515	protein binding
0.33	GO:0008270	zinc ion binding
0.32	GO:0003676	nucleic acid binding

0.81	GO:0000159	protein phosphatase type 2A complex
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.33

EC:1.2.4.2

GO:0004591

tr|T1EHL0|T1EHL0_HELRO
Uncharacterized protein
Search

0.10	Polyhomeotic homolog 1 (Fragment)

0.35	GO:0007275	multicellular organism development
0.35	GO:0070317	negative regulation of G0 to G1 transition
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:2001141	regulation of RNA biosynthetic process
0.33	GO:0010468	regulation of gene expression

0.61	GO:0008270	zinc ion binding
0.34	GO:0003677	DNA binding
0.33	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.46	GO:0000151	ubiquitin ligase complex
0.41	GO:0043234	protein complex
0.40	GO:0044446	intracellular organelle part
0.33	GO:0031974	membrane-enclosed lumen

tr|T1EHL1|T1EHL1_HELRO
Uncharacterized protein
Search

0.62	GO:0030198	extracellular matrix organization
0.54	GO:0007155	cell adhesion
0.45	GO:0007219	Notch signaling pathway
0.43	GO:0007275	multicellular organism development
0.40	GO:0030154	cell differentiation
0.40	GO:0061430	bone trabecula morphogenesis
0.40	GO:0003416	endochondral bone growth
0.39	GO:1900004	negative regulation of serine-type endopeptidase activity
0.39	GO:0050793	regulation of developmental process
0.39	GO:0071695	anatomical structure maturation

0.70	GO:0005509	calcium ion binding
0.51	GO:0008201	heparin binding
0.46	GO:0005201	extracellular matrix structural constituent
0.41	GO:0005540	hyaluronic acid binding
0.37	GO:0004867	serine-type endopeptidase inhibitor activity

0.61	GO:0031012	extracellular matrix
0.38	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0005615	extracellular space
0.30	GO:0016020	membrane

tr|T1EHL2|T1EHL2_HELRO
Uncharacterized protein
Search

tr|T1EHL3|T1EHL3_HELRO
Uncharacterized protein
Search

tr|T1EHL4|T1EHL4_HELRO
Uncharacterized protein
Search

tr|T1EHL5|T1EHL5_HELRO
Uncharacterized protein
Search

0.47	GO:1903861	positive regulation of dendrite extension
0.47	GO:0050775	positive regulation of dendrite morphogenesis
0.46	GO:0007026	negative regulation of microtubule depolymerization
0.43	GO:0000122	negative regulation of transcription by RNA polymerase II
0.43	GO:0045893	positive regulation of transcription, DNA-templated
0.37	GO:0048785	hatching gland development
0.36	GO:0035188	hatching
0.36	GO:0040025	vulval development
0.36	GO:0030218	erythrocyte differentiation
0.33	GO:0006468	protein phosphorylation

0.51	GO:0003676	nucleic acid binding
0.33	GO:0004672	protein kinase activity
0.33	GO:0046872	metal ion binding
0.33	GO:0052689	carboxylic ester hydrolase activity
0.33	GO:0003700	DNA binding transcription factor activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0008168	methyltransferase activity

0.40	GO:0005634	nucleus
0.33	GO:0005576	extracellular region
0.31	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.33	EC:3.1.1 EC:3.1.1.1	GO:0052689
0.33	KEGG:R00630	GO:0052689

tr|T1EHL6|T1EHL6_HELRO
Uncharacterized protein
Search

0.73	GO:0071805	potassium ion transmembrane transport
0.71	GO:0051260	protein homooligomerization
0.70	GO:0034765	regulation of ion transmembrane transport
0.34	GO:0006379	mRNA cleavage
0.33	GO:0006817	phosphate ion transport
0.32	GO:0006351	transcription, DNA-templated

0.78	GO:0005249	voltage-gated potassium channel activity
0.34	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.33	GO:0005315	inorganic phosphate transmembrane transporter activity
0.33	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.33	GO:0046872	metal ion binding
0.32	GO:0003676	nucleic acid binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.37	GO:0032809	neuronal cell body membrane
0.37	GO:0032590	dendrite membrane
0.37	GO:0030673	axolemma

0.34

GO:0004114

tr|T1EHL7|T1EHL7_HELRO
Uncharacterized protein
Search

0.73	GO:0043401	steroid hormone mediated signaling pathway
0.61	GO:0030522	intracellular receptor signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.43	GO:0042738	exogenous drug catabolic process
0.41	GO:0046618	drug export
0.41	GO:1902680	positive regulation of RNA biosynthetic process
0.40	GO:0042908	xenobiotic transport

0.71	GO:0003707	steroid hormone receptor activity
0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.63	GO:0004879	nuclear receptor activity
0.41	GO:0001012	RNA polymerase II regulatory region DNA binding
0.40	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.40	GO:0003690	double-stranded DNA binding
0.35	GO:0008144	drug binding
0.35	GO:0020037	heme binding
0.33	GO:0003713	transcription coactivator activity

0.61	GO:0005634	nucleus
0.40	GO:0045111	intermediate filament cytoskeleton
0.38	GO:0043233	organelle lumen
0.36	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

tr|T1EHL8|T1EHL8_HELRO
Uncharacterized protein
Search

0.80	DNL zinc finger-domain-containing protein (Fragment)

0.42	GO:0006744	ubiquinone biosynthetic process
0.38	GO:0030150	protein import into mitochondrial matrix
0.38	GO:0050821	protein stabilization
0.36	GO:0006457	protein folding
0.35	GO:0042981	regulation of apoptotic process
0.35	GO:0009301	snRNA transcription
0.34	GO:0071722	detoxification of arsenic-containing substance
0.34	GO:1901684	arsenate ion transmembrane transport
0.34	GO:0099133	ATP hydrolysis coupled anion transmembrane transport
0.33	GO:0099132	ATP hydrolysis coupled cation transmembrane transport

0.63	GO:0008270	zinc ion binding
0.37	GO:0051087	chaperone binding
0.34	GO:0015446	ATPase-coupled arsenite transmembrane transporter activity
0.32	GO:0003677	DNA binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.42	GO:0031314	extrinsic component of mitochondrial inner membrane
0.37	GO:0044428	nuclear part
0.37	GO:0031974	membrane-enclosed lumen
0.34	GO:0009570	chloroplast stroma
0.34	GO:0005667	transcription factor complex
0.30	GO:0016021	integral component of membrane

0.34

EC:3.6.3.16

GO:0015446

tr|T1EHL9|T1EHL9_HELRO
Uncharacterized protein
Search

0.60	GO:0015074	DNA integration
0.44	GO:0006278	RNA-dependent DNA biosynthetic process
0.44	GO:0006508	proteolysis
0.36	GO:0006811	ion transport
0.35	GO:0061615	glycolytic process through fructose-6-phosphate
0.34	GO:0007165	signal transduction
0.34	GO:0055085	transmembrane transport
0.33	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.32	GO:0055114	oxidation-reduction process

0.49	GO:0008270	zinc ion binding
0.48	GO:0003676	nucleic acid binding
0.48	GO:0070001	aspartic-type peptidase activity
0.46	GO:0004175	endopeptidase activity
0.44	GO:0003964	RNA-directed DNA polymerase activity
0.36	GO:0005216	ion channel activity
0.36	GO:0004888	transmembrane signaling receptor activity
0.35	GO:0003872	6-phosphofructokinase activity
0.34	GO:0004519	endonuclease activity
0.33	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

0.40	GO:0005634	nucleus
0.38	GO:0019013	viral nucleocapsid
0.30	GO:0016020	membrane

0.44

GO:0003964

tr|T1EHM0|T1EHM0_HELRO
Uncharacterized protein
Search

0.92	Disintegrin trigramin-gamma

0.60	GO:0006508	proteolysis
0.50	GO:0007229	integrin-mediated signaling pathway
0.46	GO:0009405	pathogenesis
0.41	GO:0006915	apoptotic process
0.40	GO:0007338	single fertilization
0.37	GO:0007155	cell adhesion
0.36	GO:0010604	positive regulation of macromolecule metabolic process
0.36	GO:0034241	positive regulation of macrophage fusion
0.36	GO:0042117	monocyte activation
0.36	GO:0010042	response to manganese ion

0.69	GO:0004222	metalloendopeptidase activity
0.51	GO:0046872	metal ion binding
0.48	GO:0090729	toxin activity
0.38	GO:0052689	carboxylic ester hydrolase activity
0.35	GO:0043236	laminin binding
0.35	GO:0016504	peptidase activator activity
0.35	GO:0005178	integrin binding
0.35	GO:0005518	collagen binding
0.35	GO:0017124	SH3 domain binding

0.44	GO:0005576	extracellular region
0.36	GO:0005739	mitochondrion
0.35	GO:0005886	plasma membrane
0.34	GO:0009986	cell surface
0.33	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

0.69	EC:3.4.24	GO:0004222
0.38	KEGG:R00630	GO:0052689

tr|T1EHM1|T1EHM1_HELRO
Uncharacterized protein
Search

tr|T1EHM2|T1EHM2_HELRO
Uncharacterized protein
Search

0.38	PQ loop repeat containing 1

0.34	GO:0035307	positive regulation of protein dephosphorylation
0.33	GO:0006526	arginine biosynthetic process
0.33	GO:0006886	intracellular protein transport
0.33	GO:0016192	vesicle-mediated transport
0.33	GO:0006979	response to oxidative stress
0.33	GO:0098869	cellular oxidant detoxification
0.32	GO:0055085	transmembrane transport
0.32	GO:0055114	oxidation-reduction process

0.33	GO:0004055	argininosuccinate synthase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.33	GO:0004601	peroxidase activity
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0005198	structural molecule activity
0.32	GO:0020037	heme binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0008144	drug binding

0.35	GO:0071595	Nem1-Spo7 phosphatase complex
0.34	GO:0030130	clathrin coat of trans-Golgi network vesicle
0.34	GO:0030132	clathrin coat of coated pit
0.33	GO:0005730	nucleolus
0.30	GO:0031224	intrinsic component of membrane

0.33	EC:6.3.4.5	GO:0004055
0.33	KEGG:R03532	GO:0004601

tr|T1EHM3|T1EHM3_HELRO
Uncharacterized protein
Search

0.84	DMBXa-paired class homeobox protein (Fragment)

0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.46	GO:0007275	multicellular organism development
0.40	GO:0040040	thermosensory behavior
0.40	GO:0006366	transcription by RNA polymerase II
0.39	GO:0007623	circadian rhythm
0.39	GO:0007601	visual perception
0.38	GO:0032534	regulation of microvillus assembly
0.38	GO:1902855	regulation of non-motile cilium assembly

0.63	GO:0043565	sequence-specific DNA binding
0.43	GO:0003700	DNA binding transcription factor activity
0.38	GO:0001012	RNA polymerase II regulatory region DNA binding
0.37	GO:0003690	double-stranded DNA binding
0.34	GO:1904929	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
0.33	GO:0061630	ubiquitin protein ligase activity
0.33	GO:0005515	protein binding
0.33	GO:0003743	translation initiation factor activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding

0.61	GO:0005634	nucleus
0.33	GO:0030426	growth cone
0.33	GO:0005887	integral component of plasma membrane
0.32	GO:0043234	protein complex

tr|T1EHM4|T1EHM4_HELRO
Uncharacterized protein
Search

tr|T1EHM5|T1EHM5_HELRO
Uncharacterized protein
Search

tr|T1EHM6|T1EHM6_HELRO
Uncharacterized protein
Search

0.70	Homeodomain-like DNA binding domain-containing transcription factor (Fragment)

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.45	GO:0007626	locomotory behavior
0.45	GO:0007275	multicellular organism development
0.45	GO:0009653	anatomical structure morphogenesis
0.44	GO:0019230	proprioception
0.42	GO:0030534	adult behavior
0.42	GO:0030154	cell differentiation
0.42	GO:0007567	parturition

0.64	GO:0043565	sequence-specific DNA binding
0.41	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.40	GO:0001012	RNA polymerase II regulatory region DNA binding
0.39	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
0.39	GO:0001103	RNA polymerase II repressing transcription factor binding
0.39	GO:0003690	double-stranded DNA binding
0.39	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.39	GO:0035326	enhancer binding
0.37	GO:0042803	protein homodimerization activity
0.33	GO:0017056	structural constituent of nuclear pore

0.61	GO:0005634	nucleus
0.37	GO:0000785	chromatin
0.36	GO:0043233	organelle lumen
0.35	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

tr|T1EHM7|T1EHM7_HELRO
Uncharacterized protein
Search

0.46	GO:0016571	histone methylation
0.46	GO:0000122	negative regulation of transcription by RNA polymerase II
0.45	GO:0022008	neurogenesis
0.34	GO:0006351	transcription, DNA-templated

0.51	GO:0003676	nucleic acid binding
0.46	GO:0042054	histone methyltransferase activity
0.46	GO:0003682	chromatin binding
0.36	GO:0046872	metal ion binding
0.34	GO:0003700	DNA binding transcription factor activity
0.33	GO:0005515	protein binding

0.41	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EHM8|T1EHM8_HELRO
Uncharacterized protein
Search

tr|T1EHM9|T1EHM9_HELRO
Uncharacterized protein
Search

0.44	GO:0030198	extracellular matrix organization
0.43	GO:0007275	multicellular organism development
0.43	GO:0071230	cellular response to amino acid stimulus
0.42	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
0.41	GO:0009653	anatomical structure morphogenesis
0.41	GO:0007160	cell-matrix adhesion
0.41	GO:0009888	tissue development
0.40	GO:0070208	protein heterotrimerization
0.40	GO:0030154	cell differentiation
0.39	GO:0048519	negative regulation of biological process

0.72	GO:0005201	extracellular matrix structural constituent
0.43	GO:0048407	platelet-derived growth factor binding
0.40	GO:0008201	heparin binding
0.40	GO:0002020	protease binding
0.39	GO:0004867	serine-type endopeptidase inhibitor activity
0.38	GO:0042802	identical protein binding
0.37	GO:0046332	SMAD binding
0.36	GO:0030674	protein binding, bridging
0.36	GO:0005178	integrin binding
0.34	GO:0008061	chitin binding

0.69	GO:0005581	collagen trimer
0.61	GO:0044420	extracellular matrix component
0.59	GO:0005578	proteinaceous extracellular matrix
0.44	GO:0099081	supramolecular polymer
0.40	GO:0005615	extracellular space
0.37	GO:0005783	endoplasmic reticulum
0.36	GO:0031594	neuromuscular junction
0.34	GO:0031982	vesicle
0.34	GO:0019867	outer membrane
0.33	GO:0043230	extracellular organelle

0.33

GO:0004222

tr|T1EHN0|T1EHN0_HELRO
Uncharacterized protein
Search

0.40	RNA-directed DNA polymerase from mobile element jockey (Fragment)

0.70	GO:0006278	RNA-dependent DNA biosynthetic process
0.50	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

0.70	GO:0003964	RNA-directed DNA polymerase activity
0.52	GO:0004523	RNA-DNA hybrid ribonuclease activity
0.40	GO:0003676	nucleic acid binding

0.30

GO:0031224

intrinsic component of membrane

0.70

GO:0003964

tr|T1EHN1|T1EHN1_HELRO
Uncharacterized protein
Search

tr|T1EHN2|T1EHN2_HELRO
Uncharacterized protein
Search

0.61	GATA-domain-containing protein (Fragment)

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.40	GO:0048522	positive regulation of cellular process
0.40	GO:0010557	positive regulation of macromolecule biosynthetic process
0.39	GO:0051173	positive regulation of nitrogen compound metabolic process
0.38	GO:0032502	developmental process
0.37	GO:0045580	regulation of T cell differentiation
0.37	GO:1903708	positive regulation of hemopoiesis
0.37	GO:0032501	multicellular organismal process

0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.39	GO:0044212	transcription regulatory region DNA binding
0.37	GO:0003690	double-stranded DNA binding
0.37	GO:0008134	transcription factor binding
0.36	GO:0070410	co-SMAD binding
0.35	GO:0003682	chromatin binding
0.35	GO:0003713	transcription coactivator activity
0.35	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding

0.40	GO:0005634	nucleus
0.37	GO:0005667	transcription factor complex
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

tr|T1EHN3|T1EHN3_HELRO
Uncharacterized protein
Search

0.56	GO:0040034	regulation of development, heterochronic
0.50	GO:0006357	regulation of transcription by RNA polymerase II
0.40	GO:0044268	multicellular organismal protein metabolic process
0.39	GO:0018991	oviposition
0.39	GO:0002119	nematode larval development
0.38	GO:0035282	segmentation
0.38	GO:0009792	embryo development ending in birth or egg hatching
0.37	GO:0045892	negative regulation of transcription, DNA-templated
0.34	GO:0043413	macromolecule glycosylation
0.34	GO:0009101	glycoprotein biosynthetic process

0.51	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.50	GO:0003676	nucleic acid binding
0.36	GO:0046872	metal ion binding
0.33	GO:0030246	carbohydrate binding
0.33	GO:0016757	transferase activity, transferring glycosyl groups

0.38	GO:0005634	nucleus
0.33	GO:0005794	Golgi apparatus
0.30	GO:0016020	membrane

0.33

GO:0016757

tr|T1EHN4|T1EHN4_HELRO
Uncharacterized protein
Search

0.51	GO:0040034	regulation of development, heterochronic
0.45	GO:0006357	regulation of transcription by RNA polymerase II

0.51	GO:0003676	nucleic acid binding
0.46	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding

tr|T1EHN5|T1EHN5_HELRO
Uncharacterized protein
Search

0.50	GO:0040034	regulation of development, heterochronic
0.45	GO:0006357	regulation of transcription by RNA polymerase II
0.43	GO:0035282	segmentation
0.35	GO:0006281	DNA repair
0.34	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.33	GO:0006351	transcription, DNA-templated

0.51	GO:0003676	nucleic acid binding
0.45	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.39	GO:0046872	metal ion binding
0.37	GO:0035312	5'-3' exodeoxyribonuclease activity

0.41	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EHN6|T1EHN6_HELRO
Uncharacterized protein
Search

0.56	GO:0040034	regulation of development, heterochronic
0.50	GO:0006357	regulation of transcription by RNA polymerase II
0.40	GO:0044268	multicellular organismal protein metabolic process
0.39	GO:0018991	oviposition
0.39	GO:0002119	nematode larval development
0.38	GO:0035282	segmentation
0.38	GO:0009792	embryo development ending in birth or egg hatching
0.37	GO:0045892	negative regulation of transcription, DNA-templated
0.34	GO:0043413	macromolecule glycosylation
0.34	GO:0009101	glycoprotein biosynthetic process

0.51	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.50	GO:0003676	nucleic acid binding
0.36	GO:0046872	metal ion binding
0.33	GO:0030246	carbohydrate binding
0.33	GO:0016757	transferase activity, transferring glycosyl groups

0.38	GO:0005634	nucleus
0.33	GO:0005794	Golgi apparatus
0.30	GO:0016020	membrane

0.33

GO:0016757

tr|T1EHN7|T1EHN7_HELRO
Uncharacterized protein
Search

0.10	Zinc finger protein 177 (Fragment)

0.43	GO:0035075	response to ecdysone
0.43	GO:0031936	negative regulation of chromatin silencing
0.39	GO:0045892	negative regulation of transcription, DNA-templated
0.37	GO:0006351	transcription, DNA-templated
0.35	GO:0043046	DNA methylation involved in gamete generation
0.35	GO:0006349	regulation of gene expression by genetic imprinting
0.35	GO:0006357	regulation of transcription by RNA polymerase II
0.35	GO:0051569	regulation of histone H3-K4 methylation
0.35	GO:0016569	covalent chromatin modification
0.34	GO:0008213	protein alkylation

0.51	GO:0003676	nucleic acid binding
0.41	GO:0003682	chromatin binding
0.36	GO:0046872	metal ion binding
0.36	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.35	GO:0042393	histone binding
0.33	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.33	GO:0016746	transferase activity, transferring acyl groups
0.33	GO:0020037	heme binding

0.42	GO:0005700	polytene chromosome
0.40	GO:0000785	chromatin
0.39	GO:0005634	nucleus
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.33

GO:0016705

tr|T1EHN8|T1EHN8_HELRO
Uncharacterized protein
Search

0.48	GO:0040034	regulation of development, heterochronic
0.44	GO:0006357	regulation of transcription by RNA polymerase II
0.42	GO:0035282	segmentation
0.34	GO:0010469	regulation of receptor activity
0.34	GO:0045892	negative regulation of transcription, DNA-templated
0.33	GO:0032259	methylation
0.33	GO:0098655	cation transmembrane transport
0.33	GO:0006351	transcription, DNA-templated

0.51	GO:0003676	nucleic acid binding
0.44	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.38	GO:0046872	metal ion binding
0.34	GO:0008083	growth factor activity
0.34	GO:0005261	cation channel activity
0.33	GO:0008168	methyltransferase activity

0.39	GO:0005634	nucleus
0.33	GO:0005576	extracellular region
0.30	GO:0016020	membrane

0.33

GO:0008168

tr|T1EHN9|T1EHN9_HELRO
Uncharacterized protein
Search

0.10	Class E basic helix-loop-helix protein 22 (Fragment)

0.62	GO:0030154	cell differentiation
0.60	GO:0048856	anatomical structure development
0.56	GO:0006357	regulation of transcription by RNA polymerase II
0.55	GO:0032501	multicellular organismal process
0.46	GO:0046671	negative regulation of retinal cell programmed cell death
0.41	GO:0045893	positive regulation of transcription, DNA-templated
0.37	GO:0120036	plasma membrane bounded cell projection organization
0.36	GO:0006351	transcription, DNA-templated
0.35	GO:0045892	negative regulation of transcription, DNA-templated
0.35	GO:0006935	chemotaxis

0.68	GO:0046983	protein dimerization activity
0.55	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.35	GO:0003682	chromatin binding
0.35	GO:0042802	identical protein binding
0.33	GO:0003677	DNA binding

0.37

GO:0005634

nucleus

tr|T1EHP0|T1EHP0_HELRO
Uncharacterized protein
Search

COA4

0.70	Cytochrome c oxidase assembly factor 4 homolog, mitochondrial

0.57

GO:0033617

mitochondrial respiratory chain complex IV assembly

0.61	GO:0005739	mitochondrion
0.55	GO:0031970	organelle envelope lumen

tr|T1EHP1|T1EHP1_HELRO
Uncharacterized protein
Search

0.79	GO:0060079	excitatory postsynaptic potential
0.60	GO:0034220	ion transmembrane transport
0.43	GO:0035094	response to nicotine
0.42	GO:0006874	cellular calcium ion homeostasis
0.41	GO:0051239	regulation of multicellular organismal process
0.41	GO:0006816	calcium ion transport
0.40	GO:0098739	import across plasma membrane
0.40	GO:0050890	cognition
0.39	GO:0043410	positive regulation of MAPK cascade
0.39	GO:1905920	positive regulation of CoA-transferase activity

0.83	GO:0022848	acetylcholine-gated cation-selective channel activity
0.70	GO:0004888	transmembrane signaling receptor activity
0.40	GO:0042166	acetylcholine binding
0.39	GO:0017081	chloride channel regulator activity
0.39	GO:0001540	amyloid-beta binding
0.38	GO:0015643	toxic substance binding
0.37	GO:0042803	protein homodimerization activity
0.34	GO:0005262	calcium channel activity

0.79	GO:0045211	postsynaptic membrane
0.71	GO:0030054	cell junction
0.52	GO:0043204	perikaryon
0.50	GO:0030424	axon
0.50	GO:0030425	dendrite
0.41	GO:0005892	acetylcholine-gated channel complex
0.37	GO:0005737	cytoplasm
0.36	GO:0032589	neuron projection membrane
0.36	GO:0009897	external side of plasma membrane
0.36	GO:0016324	apical plasma membrane

tr|T1EHP2|T1EHP2_HELRO
Uncharacterized protein
Search

0.59	Neuronal acetylcholine receptor subunit alpha-7

0.79	GO:0060079	excitatory postsynaptic potential
0.60	GO:0034220	ion transmembrane transport
0.44	GO:0017085	response to insecticide
0.44	GO:0007271	synaptic transmission, cholinergic
0.43	GO:0046716	muscle cell cellular homeostasis
0.38	GO:0006812	cation transport
0.35	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.34	GO:0035094	response to nicotine
0.34	GO:0007274	neuromuscular synaptic transmission
0.34	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound

0.82	GO:0022848	acetylcholine-gated cation-selective channel activity
0.70	GO:0099600	transmembrane receptor activity
0.34	GO:0042166	acetylcholine binding

0.78	GO:0045211	postsynaptic membrane
0.71	GO:0030054	cell junction
0.44	GO:0005892	acetylcholine-gated channel complex

tr|T1EHP3|T1EHP3_HELRO
Uncharacterized protein
Search

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.45	GO:0007210	serotonin receptor signaling pathway
0.43	GO:0019933	cAMP-mediated signaling
0.42	GO:0032870	cellular response to hormone stimulus
0.42	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
0.42	GO:0035624	receptor transactivation
0.42	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
0.41	GO:0051044	positive regulation of membrane protein ectodomain proteolysis
0.41	GO:0050995	negative regulation of lipid catabolic process
0.41	GO:0032148	activation of protein kinase B activity

0.72	GO:0004930	G-protein coupled receptor activity
0.53	GO:0030594	neurotransmitter receptor activity
0.45	GO:0099589	serotonin receptor activity
0.42	GO:0031696	alpha-2C adrenergic receptor binding
0.42	GO:0032795	heterotrimeric G-protein binding
0.42	GO:0051380	norepinephrine binding
0.42	GO:0051379	epinephrine binding
0.42	GO:0031996	thioesterase binding
0.39	GO:0019901	protein kinase binding
0.39	GO:0042803	protein homodimerization activity

0.49	GO:0005887	integral component of plasma membrane
0.39	GO:0043235	receptor complex
0.34	GO:0005622	intracellular

tr|T1EHP4|T1EHP4_HELRO
Uncharacterized protein
Search

tr|T1EHP5|T1EHP5_HELRO
Histone H2A
Search

0.41	GO:0007526	larval somatic muscle development
0.39	GO:0006325	chromatin organization
0.38	GO:0045814	negative regulation of gene expression, epigenetic
0.38	GO:0016458	gene silencing
0.37	GO:0045892	negative regulation of transcription, DNA-templated
0.37	GO:0065004	protein-DNA complex assembly
0.37	GO:0006323	DNA packaging
0.34	GO:0042742	defense response to bacterium
0.33	GO:0006352	DNA-templated transcription, initiation
0.32	GO:0055114	oxidation-reduction process

0.74	GO:0046982	protein heterodimerization activity
0.55	GO:0003677	DNA binding
0.33	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.33	GO:0004497	monooxygenase activity
0.33	GO:0020037	heme binding
0.33	GO:0005506	iron ion binding

0.75	GO:0000786	nucleosome
0.61	GO:0005634	nucleus
0.41	GO:0005704	polytene chromosome band
0.36	GO:0031974	membrane-enclosed lumen
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0016705

tr|T1EHP6|T1EHP6_HELRO
Histone H2A
Search

tr|T1EHP7|T1EHP7_HELRO
Uncharacterized protein
Search

0.97	myeloma-overexpressed gene 2 protein homolog

0.80	GO:0034644	cellular response to UV
0.75	GO:0008284	positive regulation of cell proliferation
0.67	GO:2000435	negative regulation of protein neddylation
0.63	GO:0051220	cytoplasmic sequestering of protein
0.42	GO:0060326	cell chemotaxis
0.40	GO:0006955	immune response

0.43	GO:0005515	protein binding
0.43	GO:0031409	pigment binding
0.40	GO:0030545	receptor regulator activity

0.77	GO:0008180	COP9 signalosome
0.72	GO:0000790	nuclear chromatin
0.67	GO:0005654	nucleoplasm
0.47	GO:0005737	cytoplasm
0.38	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

tr|T1EHP8|T1EHP8_HELRO
Uncharacterized protein
Search

0.38	GO:0045662	negative regulation of myoblast differentiation
0.37	GO:0043484	regulation of RNA splicing

0.54

GO:0046872

metal ion binding

0.30

GO:0044425

membrane part

tr|T1EHP9|T1EHP9_HELRO
Histone H2A
Search

tr|T1EHQ0|T1EHQ0_HELRO
Uncharacterized protein
Search

tr|T1EHQ1|T1EHQ1_HELRO
Uncharacterized protein
Search

0.74	Even-skipped (Fragment)

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.46	GO:0007376	cephalic furrow formation
0.45	GO:0009997	negative regulation of cardioblast cell fate specification
0.45	GO:0007377	germ-band extension
0.45	GO:0007512	adult heart development
0.44	GO:1901739	regulation of myoblast fusion
0.44	GO:0008045	motor neuron axon guidance
0.43	GO:0050770	regulation of axonogenesis

0.64	GO:0043565	sequence-specific DNA binding
0.43	GO:0035326	enhancer binding
0.43	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.42	GO:0001012	RNA polymerase II regulatory region DNA binding
0.40	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EHQ2|T1EHQ2_HELRO
Uncharacterized protein
Search

0.75	GO:0000723	telomere maintenance
0.67	GO:0032392	DNA geometric change
0.62	GO:0006281	DNA repair
0.58	GO:0006310	DNA recombination
0.35	GO:0006511	ubiquitin-dependent protein catabolic process

0.67	GO:0003678	DNA helicase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003676	nucleic acid binding

0.33

GO:0005856

cytoskeleton

tr|T1EHQ3|T1EHQ3_HELRO
Uncharacterized protein
Search

tr|T1EHQ4|T1EHQ4_HELRO
Uncharacterized protein
Search

0.58	Homeobox protein abdominal-B (inferred by orthology to a D. melanogaster protein)

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.54	GO:0007275	multicellular organism development
0.47	GO:0006351	transcription, DNA-templated
0.39	GO:0003006	developmental process involved in reproduction
0.39	GO:1902680	positive regulation of RNA biosynthetic process
0.38	GO:1902679	negative regulation of RNA biosynthetic process
0.37	GO:0030154	cell differentiation
0.37	GO:0009653	anatomical structure morphogenesis

0.63	GO:0043565	sequence-specific DNA binding
0.40	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.40	GO:0001012	RNA polymerase II regulatory region DNA binding
0.39	GO:0003690	double-stranded DNA binding
0.33	GO:0005515	protein binding

0.61

GO:0005634

nucleus

tr|T1EHQ5|T1EHQ5_HELRO
Uncharacterized protein
Search

0.67	GO:0006278	RNA-dependent DNA biosynthetic process
0.44	GO:0016266	O-glycan processing
0.43	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.38	GO:0007018	microtubule-based movement
0.37	GO:0015074	DNA integration

0.67	GO:0003964	RNA-directed DNA polymerase activity
0.44	GO:0004519	endonuclease activity
0.44	GO:0016263	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity
0.39	GO:0003777	microtubule motor activity
0.39	GO:0008017	microtubule binding
0.38	GO:0003779	actin binding
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0003676	nucleic acid binding

0.39	GO:0016459	myosin complex
0.30	GO:0016020	membrane

0.67

GO:0003964

tr|T1EHQ6|T1EHQ6_HELRO
Histone H2A
Search

tr|T1EHQ7|T1EHQ7_HELRO
Uncharacterized protein
Search

0.65	Tyramine/octopamine receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.52	GO:0034776	response to histamine
0.52	GO:0048148	behavioral response to cocaine
0.52	GO:0001975	response to amphetamine
0.50	GO:0046717	acid secretion
0.50	GO:0050883	musculoskeletal movement, spinal reflex action
0.50	GO:0050709	negative regulation of protein secretion
0.50	GO:0060160	negative regulation of dopamine receptor signaling pathway
0.49	GO:0002016	regulation of blood volume by renin-angiotensin
0.49	GO:0007626	locomotory behavior

0.72	GO:0004930	G-protein coupled receptor activity
0.67	GO:0030594	neurotransmitter receptor activity
0.46	GO:0035240	dopamine binding
0.43	GO:0051380	norepinephrine binding
0.43	GO:0051379	epinephrine binding
0.42	GO:0019904	protein domain specific binding
0.39	GO:0042802	identical protein binding
0.39	GO:0031748	D1 dopamine receptor binding
0.35	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.35	GO:0001653	peptide receptor activity

0.56	GO:0005887	integral component of plasma membrane
0.40	GO:0098794	postsynapse
0.37	GO:0030139	endocytic vesicle
0.37	GO:0045177	apical part of cell
0.36	GO:0042995	cell projection

0.35

GO:0004715

tr|T1EHQ8|T1EHQ8_HELRO
Uncharacterized protein
Search

0.10	50S ribosome-binding GTPase (Fragment)

0.51	GO:0042254	ribosome biogenesis
0.36	GO:0044065	regulation of respiratory system process
0.36	GO:0070129	regulation of mitochondrial translation

0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.63	GO:0003924	GTPase activity
0.60	GO:0000287	magnesium ion binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003723	RNA binding

0.41	GO:0005737	cytoplasm
0.34	GO:0031974	membrane-enclosed lumen
0.34	GO:0019866	organelle inner membrane
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane

tr|T1EHQ9|T1EHQ9_HELRO
Uncharacterized protein
Search

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.45	GO:0048518	positive regulation of biological process
0.44	GO:0030154	cell differentiation
0.43	GO:0060159	regulation of dopamine receptor signaling pathway
0.43	GO:0001964	startle response
0.43	GO:0045187	regulation of circadian sleep/wake cycle, sleep
0.41	GO:0042594	response to starvation
0.40	GO:0048793	pronephros development

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.46	GO:0001012	RNA polymerase II regulatory region DNA binding
0.44	GO:0003690	double-stranded DNA binding
0.33	GO:0005515	protein binding
0.33	GO:0051920	peroxiredoxin activity

0.61	GO:0005634	nucleus
0.43	GO:0031974	membrane-enclosed lumen
0.40	GO:0043232	intracellular non-membrane-bounded organelle
0.39	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:1.11.1.15

GO:0051920

tr|T1EHR0|T1EHR0_HELRO
Diacylglycerol kinase
Search

DGKD

0.49	Diacylglycerol kinase delta

0.83	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
0.62	GO:0035556	intracellular signal transduction
0.57	GO:0016310	phosphorylation
0.50	GO:0051259	protein oligomerization
0.46	GO:0010033	response to organic substance
0.45	GO:0046473	phosphatidic acid metabolic process
0.41	GO:0046339	diacylglycerol metabolic process
0.37	GO:0030168	platelet activation
0.35	GO:0007173	epidermal growth factor receptor signaling pathway
0.35	GO:0016049	cell growth

0.80	GO:0004143	diacylglycerol kinase activity
0.76	GO:0003951	NAD+ kinase activity
0.63	GO:0042803	protein homodimerization activity
0.62	GO:0046982	protein heterodimerization activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0019992	diacylglycerol binding
0.33	GO:0046872	metal ion binding

0.45	GO:0005622	intracellular
0.44	GO:0031982	vesicle
0.41	GO:0012505	endomembrane system
0.40	GO:0005886	plasma membrane

0.80	EC:2.7.1.107	GO:0004143
0.76	KEGG:R00104	GO:0003951

tr|T1EHR1|T1EHR1_HELRO
Uncharacterized protein
Search

0.62	Voltage dependent L type calcium channel subunit

0.77	GO:0070588	calcium ion transmembrane transport
0.76	GO:0034765	regulation of ion transmembrane transport
0.44	GO:0035545	determination of left/right asymmetry in nervous system
0.42	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.41	GO:0007626	locomotory behavior
0.41	GO:0042594	response to starvation
0.40	GO:0009408	response to heat
0.39	GO:0001505	regulation of neurotransmitter levels
0.37	GO:0086010	membrane depolarization during action potential

0.82	GO:0005245	voltage-gated calcium channel activity
0.66	GO:0005509	calcium ion binding

0.81	GO:0005891	voltage-gated calcium channel complex
0.44	GO:0048787	presynaptic active zone membrane

tr|T1EHR2|T1EHR2_HELRO
Uncharacterized protein
Search

KCNH8

0.86	potassium voltage-gated channel subfamily H member 8

0.75	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.66	GO:0023014	signal transduction by protein phosphorylation
0.63	GO:0000160	phosphorelay signal transduction system
0.45	GO:0042391	regulation of membrane potential
0.34	GO:0043066	negative regulation of apoptotic process
0.34	GO:0006357	regulation of transcription by RNA polymerase II

0.78	GO:0005249	voltage-gated potassium channel activity
0.66	GO:0000155	phosphorelay sensor kinase activity
0.37	GO:0043855	cyclic nucleotide-gated ion channel activity
0.36	GO:0042802	identical protein binding
0.35	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.35	GO:0003924	GTPase activity
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0019001	guanyl nucleotide binding
0.33	GO:0030551	cyclic nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding

0.45	GO:0005622	intracellular
0.42	GO:0005887	integral component of plasma membrane
0.36	GO:0034705	potassium channel complex

0.66

GO:0000155

tr|T1EHR3|T1EHR3_HELRO
Voltage-dependent L-type calcium channel subunit alpha
Search

CACNA1C

0.62	Voltage-dependent L-type calcium channel subunit alpha

0.75	GO:0034765	regulation of ion transmembrane transport
0.75	GO:0070588	calcium ion transmembrane transport
0.39	GO:0086010	membrane depolarization during action potential
0.36	GO:0086016	AV node cell action potential
0.36	GO:0086014	atrial cardiac muscle cell action potential
0.36	GO:0098911	regulation of ventricular cardiac muscle cell action potential
0.36	GO:0035115	embryonic forelimb morphogenesis
0.36	GO:0086091	regulation of heart rate by cardiac conduction
0.35	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.35	GO:0043010	camera-type eye development

0.79	GO:0005245	voltage-gated calcium channel activity
0.37	GO:0005509	calcium ion binding
0.36	GO:0051393	alpha-actinin binding
0.35	GO:0005516	calmodulin binding

0.78	GO:0005891	voltage-gated calcium channel complex
0.36	GO:0030315	T-tubule
0.35	GO:0014069	postsynaptic density
0.32	GO:0005737	cytoplasm

tr|T1EHR4|T1EHR4_HELRO
Uncharacterized protein
Search

0.44	GO:0007218	neuropeptide signaling pathway
0.42	GO:0007229	integrin-mediated signaling pathway
0.36	GO:0010646	regulation of cell communication
0.36	GO:0023051	regulation of signaling
0.35	GO:0070932	histone H3 deacetylation
0.35	GO:0060255	regulation of macromolecule metabolic process
0.35	GO:0048583	regulation of response to stimulus
0.35	GO:0042127	regulation of cell proliferation
0.35	GO:0065009	regulation of molecular function
0.35	GO:0080090	regulation of primary metabolic process

0.39	GO:0016630	protochlorophyllide reductase activity
0.37	GO:0019899	enzyme binding
0.35	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
0.35	GO:0098772	molecular function regulator
0.35	GO:0004523	RNA-DNA hybrid ribonuclease activity
0.34	GO:0003779	actin binding
0.34	GO:0003700	DNA binding transcription factor activity
0.34	GO:0003676	nucleic acid binding
0.33	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
0.33	GO:0022857	transmembrane transporter activity

0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.39

EC:1.3.1.33

GO:0016630

tr|T1EHR5|T1EHR5_HELRO
Uncharacterized protein
Search

tr|T1EHR6|T1EHR6_HELRO
Uncharacterized protein
Search

0.33	Calcium-transporting ATPase

0.72	GO:0070588	calcium ion transmembrane transport
0.65	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.39	GO:0006874	cellular calcium ion homeostasis
0.36	GO:0070574	cadmium ion transmembrane transport
0.36	GO:0060003	copper ion export
0.36	GO:0071577	zinc II ion transmembrane transport
0.36	GO:0034505	tooth mineralization
0.36	GO:0048919	posterior lateral line neuromast development
0.36	GO:0048840	otolith development
0.35	GO:0030282	bone mineralization

0.75	GO:0005388	calcium-transporting ATPase activity
0.52	GO:1901265	nucleoside phosphate binding
0.51	GO:0097367	carbohydrate derivative binding
0.51	GO:0008144	drug binding
0.51	GO:0036094	small molecule binding
0.50	GO:0043168	anion binding
0.36	GO:0016463	zinc-exporting ATPase activity
0.36	GO:0008551	cadmium-exporting ATPase activity
0.36	GO:0004008	copper-exporting ATPase activity
0.35	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding

0.38	GO:0005887	integral component of plasma membrane
0.36	GO:0043231	intracellular membrane-bounded organelle

0.75

EC:3.6.3.8

GO:0005388

tr|T1EHR7|T1EHR7_HELRO
Uncharacterized protein
Search

0.64	Cholecystokinin receptor type A

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.39	GO:0007610	behavior
0.37	GO:0032501	multicellular organismal process
0.37	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.36	GO:0007528	neuromuscular junction development
0.36	GO:0046883	regulation of hormone secretion
0.36	GO:1901652	response to peptide
0.36	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.36	GO:0060322	head development
0.36	GO:0000904	cell morphogenesis involved in differentiation

0.73	GO:0015054	gastrin receptor activity
0.44	GO:0004983	neuropeptide Y receptor activity
0.37	GO:0004951	cholecystokinin receptor activity
0.37	GO:0050254	rhodopsin kinase activity
0.36	GO:0042277	peptide binding
0.36	GO:0004715	non-membrane spanning protein tyrosine kinase activity

0.37	GO:0005887	integral component of plasma membrane
0.36	GO:0043195	terminal bouton
0.36	GO:0043025	neuronal cell body

0.37

EC:2.7.11.14

GO:0050254

tr|T1EHR8|T1EHR8_HELRO
Uncharacterized protein
Search

0.45	T. brucei spp.-specific protein

0.34	GO:0051640	organelle localization
0.34	GO:0008214	protein dealkylation
0.34	GO:0070988	demethylation
0.34	GO:0140029	exocytic process
0.34	GO:0022406	membrane docking
0.34	GO:0006741	NADP biosynthetic process
0.34	GO:0060729	intestinal epithelial structure maintenance
0.34	GO:0043249	erythrocyte maturation
0.33	GO:0090304	nucleic acid metabolic process
0.33	GO:0007571	age-dependent general metabolic decline

0.34	GO:0005509	calcium ion binding
0.34	GO:0004004	ATP-dependent RNA helicase activity
0.34	GO:0051723	protein methylesterase activity
0.34	GO:0097367	carbohydrate derivative binding
0.33	GO:0003951	NAD+ kinase activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0043168	anion binding
0.33	GO:0003721	telomerase RNA reverse transcriptase activity
0.33	GO:0008144	drug binding
0.33	GO:0003676	nucleic acid binding

0.33	GO:0045095	keratin filament
0.33	GO:0043231	intracellular membrane-bounded organelle
0.32	GO:0044444	cytoplasmic part
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.33	EC:2.7.1.23	GO:0003951
0.33	KEGG:R00104	GO:0003951

tr|T1EHR9|T1EHR9_HELRO
Uncharacterized protein
Search

0.62	GO:0006468	protein phosphorylation
0.46	GO:0045214	sarcomere organization
0.46	GO:0071688	striated muscle myosin thick filament assembly
0.43	GO:0006941	striated muscle contraction
0.42	GO:0007015	actin filament organization
0.40	GO:0048769	sarcomerogenesis
0.39	GO:0009888	tissue development
0.38	GO:0060047	heart contraction
0.38	GO:0060538	skeletal muscle organ development
0.38	GO:0007507	heart development

0.63	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0008307	structural constituent of muscle
0.44	GO:0097493	structural molecule activity conferring elasticity
0.44	GO:0051371	muscle alpha-actinin binding
0.41	GO:0051015	actin filament binding
0.35	GO:0005089	Rho guanyl-nucleotide exchange factor activity

0.44	GO:0030018	Z disc
0.44	GO:0005859	muscle myosin complex
0.43	GO:0031430	M band
0.30	GO:0016020	membrane

tr|T1EHS0|T1EHS0_HELRO
Uncharacterized protein
Search

0.40	Putative syntaxin-binding protein 2 (Fragment)

0.80

GO:0006904

vesicle docking involved in exocytosis

0.30

GO:0031224

intrinsic component of membrane

tr|T1EHS1|T1EHS1_HELRO
Uncharacterized protein
Search

0.10	ATP synthase subunit a

0.70	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.70	GO:0006754	ATP biosynthetic process

0.63

GO:0015078

hydrogen ion transmembrane transporter activity

0.72	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)
0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

tr|T1EHS2|T1EHS2_HELRO
Uncharacterized protein
Search

0.68	Octopamine receptor beta-3R

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.50	GO:0019933	cAMP-mediated signaling
0.46	GO:0008582	regulation of synaptic growth at neuromuscular junction
0.42	GO:1904398	positive regulation of neuromuscular junction development
0.42	GO:0030728	ovulation
0.42	GO:1904397	negative regulation of neuromuscular junction development
0.42	GO:0051964	negative regulation of synapse assembly
0.41	GO:0051965	positive regulation of synapse assembly
0.41	GO:0048639	positive regulation of developmental growth
0.41	GO:0048640	negative regulation of developmental growth

0.72	GO:0004930	G-protein coupled receptor activity
0.51	GO:0030594	neurotransmitter receptor activity
0.36	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.35	GO:0003700	DNA binding transcription factor activity
0.35	GO:0099589	serotonin receptor activity
0.32	GO:0008144	drug binding

0.46	GO:0005887	integral component of plasma membrane
0.36	GO:0005622	intracellular

0.36

GO:0004715

tr|T1EHS3|T1EHS3_HELRO
Uncharacterized protein
Search

0.59	Rhabdomeric opsin

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.67	GO:0018298	protein-chromophore linkage
0.64	GO:0007602	phototransduction
0.64	GO:0007601	visual perception
0.42	GO:0009584	detection of visible light
0.39	GO:0042752	regulation of circadian rhythm
0.38	GO:0071482	cellular response to light stimulus
0.37	GO:0042221	response to chemical
0.36	GO:0007608	sensory perception of smell
0.36	GO:0050906	detection of stimulus involved in sensory perception

0.72	GO:0004930	G-protein coupled receptor activity
0.71	GO:0009881	photoreceptor activity
0.42	GO:0016500	protein-hormone receptor activity
0.40	GO:0005502	11-cis retinal binding
0.38	GO:0001653	peptide receptor activity
0.37	GO:0015464	acetylcholine receptor activity
0.36	GO:0004984	olfactory receptor activity
0.36	GO:0004744	retinal isomerase activity
0.34	GO:0004896	cytokine receptor activity
0.34	GO:0005549	odorant binding

0.36	GO:0005886	plasma membrane
0.34	GO:0097730	non-motile cilium
0.33	GO:0044441	ciliary part
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0043005	neuron projection
0.30	GO:0016021	integral component of membrane

0.36

KEGG:R02126

GO:0004744

tr|T1EHS4|T1EHS4_HELRO
Uncharacterized protein
Search

HINFP

0.94	Histone H4 transcription factor

0.56	GO:0045445	myoblast differentiation
0.55	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
0.52	GO:0000077	DNA damage checkpoint
0.51	GO:0001701	in utero embryonic development
0.51	GO:0000122	negative regulation of transcription by RNA polymerase II
0.49	GO:0045893	positive regulation of transcription, DNA-templated
0.46	GO:0045184	establishment of protein localization
0.45	GO:0006281	DNA repair
0.43	GO:0006351	transcription, DNA-templated

0.54	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.52	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.52	GO:0042393	histone binding
0.52	GO:0003713	transcription coactivator activity
0.51	GO:0003682	chromatin binding
0.48	GO:0019899	enzyme binding
0.37	GO:0046872	metal ion binding
0.33	GO:0016887	ATPase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding

0.55	GO:0015030	Cajal body
0.36	GO:0005730	nucleolus

0.33

GO:0016887

tr|T1EHS5|T1EHS5_HELRO
Uncharacterized protein
Search

0.24	Zinc finger protein

0.51	GO:1903506	regulation of nucleic acid-templated transcription
0.51	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.50	GO:0010468	regulation of gene expression
0.39	GO:0070895	negative regulation of transposon integration
0.37	GO:0040034	regulation of development, heterochronic
0.35	GO:1902679	negative regulation of RNA biosynthetic process
0.35	GO:0006351	transcription, DNA-templated

0.51	GO:0003676	nucleic acid binding
0.48	GO:0046872	metal ion binding
0.44	GO:0003700	DNA binding transcription factor activity

0.42	GO:0005622	intracellular
0.37	GO:0043227	membrane-bounded organelle

tr|T1EHS6|T1EHS6_HELRO
Uncharacterized protein
Search

MHC

0.46	Myosin heavy chain

0.74	GO:0007018	microtubule-based movement
0.40	GO:0060279	positive regulation of ovulation
0.38	GO:0007626	locomotory behavior
0.35	GO:0048193	Golgi vesicle transport
0.34	GO:0007155	cell adhesion

0.76	GO:0051015	actin filament binding
0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005516	calmodulin binding

0.77	GO:0016459	myosin complex
0.39	GO:0030016	myofibril
0.38	GO:0044449	contractile fiber part
0.30	GO:0016020	membrane

tr|T1EHS7|T1EHS7_HELRO
Uncharacterized protein
Search

DCKL1B

0.89	Doublecortin-like kinase 1b

0.63	GO:0006468	protein phosphorylation
0.56	GO:0035556	intracellular signal transduction
0.53	GO:0018209	peptidyl-serine modification
0.52	GO:1900181	negative regulation of protein localization to nucleus
0.48	GO:0018210	peptidyl-threonine modification
0.42	GO:0021860	pyramidal neuron development
0.41	GO:0021766	hippocampus development
0.40	GO:0000226	microtubule cytoskeleton organization

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.43	GO:0005622	intracellular
0.39	GO:0043226	organelle
0.38	GO:0099512	supramolecular fiber
0.30	GO:0031224	intrinsic component of membrane

tr|T1EHS8|T1EHS8_HELRO
Uncharacterized protein
Search

NEK8

0.91	NIMA (Never in mitosis gene a)-related kinase 8

0.66	GO:0035330	regulation of hippo signaling
0.63	GO:0006468	protein phosphorylation
0.62	GO:0007368	determination of left/right symmetry
0.60	GO:0007507	heart development
0.59	GO:0009887	animal organ morphogenesis

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.68	GO:0097543	ciliary inversin compartment
0.64	GO:0097546	ciliary base
0.30	GO:0031224	intrinsic component of membrane

tr|T1EHS9|T1EHS9_HELRO
Uncharacterized protein
Search

MORC2

0.72	MORC family CW-type zinc finger protein 2

0.42	GO:0044026	DNA hypermethylation
0.42	GO:2000143	negative regulation of DNA-templated transcription, initiation
0.41	GO:0043046	DNA methylation involved in gamete generation
0.41	GO:0010529	negative regulation of transposition
0.40	GO:0007283	spermatogenesis
0.39	GO:0040029	regulation of gene expression, epigenetic
0.33	GO:0006631	fatty acid metabolic process
0.33	GO:0030154	cell differentiation
0.33	GO:0007275	multicellular organism development
0.32	GO:0055114	oxidation-reduction process

0.61	GO:0008270	zinc ion binding
0.32	GO:0016491	oxidoreductase activity

0.45	GO:0005634	nucleus
0.45	GO:0005829	cytosol

0.32

GO:0016491

tr|T1EHT0|T1EHT0_HELRO
Uncharacterized protein
Search

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.43	GO:0009298	GDP-mannose biosynthetic process
0.43	GO:0035434	copper ion transmembrane transport
0.41	GO:0006402	mRNA catabolic process
0.40	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.38	GO:0006396	RNA processing
0.38	GO:0006508	proteolysis
0.37	GO:0005975	carbohydrate metabolic process
0.37	GO:0006518	peptide metabolic process
0.37	GO:0043604	amide biosynthetic process

0.72	GO:0004930	G-protein coupled receptor activity
0.51	GO:0001653	peptide receptor activity
0.43	GO:0005375	copper ion transmembrane transporter activity
0.42	GO:0004476	mannose-6-phosphate isomerase activity
0.42	GO:0004654	polyribonucleotide nucleotidyltransferase activity
0.40	GO:0004222	metalloendopeptidase activity
0.40	GO:0004984	olfactory receptor activity
0.39	GO:0042923	neuropeptide binding
0.39	GO:0019956	chemokine binding
0.38	GO:0003735	structural constituent of ribosome

0.39	GO:0005576	extracellular region
0.38	GO:0005840	ribosome
0.37	GO:0043005	neuron projection
0.37	GO:0005886	plasma membrane
0.36	GO:0042719	mitochondrial intermembrane space protein transporter complex
0.36	GO:0042721	mitochondrial inner membrane protein insertion complex
0.30	GO:0016021	integral component of membrane

0.42

EC:5.3.1.8

GO:0004476

tr|T1EHT1|T1EHT1_HELRO
Uncharacterized protein
Search

0.51	Glibenclamide-sensitive voltage-gated potassium channel

0.78	GO:0051260	protein homooligomerization
0.77	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.39	GO:0001508	action potential
0.38	GO:0007637	proboscis extension reflex
0.38	GO:0048047	mating behavior, sex discrimination
0.38	GO:0010960	magnesium ion homeostasis
0.38	GO:0009582	detection of abiotic stimulus
0.38	GO:0009581	detection of external stimulus
0.38	GO:0060025	regulation of synaptic activity

0.78	GO:0005249	voltage-gated potassium channel activity
0.36	GO:0097718	disordered domain specific binding
0.35	GO:0030955	potassium ion binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.38	GO:0030424	axon
0.38	GO:0043679	axon terminus
0.36	GO:0043025	neuronal cell body
0.36	GO:0030425	dendrite
0.35	GO:0009986	cell surface
0.35	GO:0030054	cell junction

tr|T1EHT2|T1EHT2_HELRO
Uncharacterized protein
Search

0.82	Putative syntaxin-binding protein 2 (Fragment)

0.34	GO:0006904	vesicle docking involved in exocytosis
0.33	GO:0042073	intraciliary transport
0.33	GO:0021628	olfactory nerve formation
0.33	GO:0071699	olfactory placode morphogenesis
0.33	GO:0006106	fumarate metabolic process
0.33	GO:0060271	cilium assembly
0.33	GO:0006511	ubiquitin-dependent protein catabolic process
0.33	GO:0016567	protein ubiquitination
0.33	GO:0010951	negative regulation of endopeptidase activity
0.33	GO:0006099	tricarboxylic acid cycle

0.33	GO:0061630	ubiquitin protein ligase activity
0.33	GO:0004867	serine-type endopeptidase inhibitor activity
0.33	GO:0004333	fumarate hydratase activity
0.33	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity
0.33	GO:0015631	tubulin binding
0.33	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0008271	secondary active sulfate transmembrane transporter activity
0.33	GO:0003676	nucleic acid binding
0.32	GO:0005509	calcium ion binding
0.32	GO:0003700	DNA binding transcription factor activity

0.33	GO:0030992	intraciliary transport particle B
0.33	GO:0031514	motile cilium
0.33	GO:0045239	tricarboxylic acid cycle enzyme complex
0.33	GO:0009331	glycerol-3-phosphate dehydrogenase complex
0.32	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016020	membrane

0.33	EC:4.2.1.2	GO:0004333
0.33	KEGG:R01082	GO:0004333

tr|T1EHT3|T1EHT3_HELRO
Uncharacterized protein
Search

TRPC4

0.95	Short transient receptor potential channel 4

0.77	GO:0070588	calcium ion transmembrane transport
0.52	GO:0014051	gamma-aminobutyric acid secretion
0.51	GO:0070509	calcium ion import
0.49	GO:0048709	oligodendrocyte differentiation
0.45	GO:0006828	manganese ion transport
0.45	GO:0051480	regulation of cytosolic calcium ion concentration
0.39	GO:0007338	single fertilization
0.35	GO:0051924	regulation of calcium ion transport
0.32	GO:0043043	peptide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process

0.80	GO:0005262	calcium channel activity
0.51	GO:0008013	beta-catenin binding
0.50	GO:0045296	cadherin binding
0.49	GO:0070679	inositol 1,4,5 trisphosphate binding
0.33	GO:0005509	calcium ion binding
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0003723	RNA binding

0.50	GO:0016323	basolateral plasma membrane
0.49	GO:0034704	calcium channel complex
0.49	GO:0030863	cortical cytoskeleton
0.49	GO:0005901	caveola
0.48	GO:0005911	cell-cell junction
0.48	GO:0009986	cell surface
0.41	GO:0005887	integral component of plasma membrane
0.40	GO:0043234	protein complex
0.32	GO:0005840	ribosome

tr|T1EHT4|T1EHT4_HELRO
Uncharacterized protein
Search

LETM1

0.88	Leucine zipper and EF-hand containing transmembrane protein 1

0.50	GO:0099093	mitochondrial calcium release
0.50	GO:0006851	mitochondrial calcium ion transmembrane transport
0.48	GO:0051560	mitochondrial calcium ion homeostasis
0.47	GO:0034214	protein hexamerization
0.45	GO:0042407	cristae formation
0.44	GO:0051260	protein homooligomerization
0.39	GO:0070584	mitochondrion morphogenesis
0.38	GO:0071456	cellular response to hypoxia
0.38	GO:0099643	signal release from synapse
0.38	GO:0099531	presynaptic process involved in chemical synaptic transmission

0.74	GO:0043022	ribosome binding
0.67	GO:0005509	calcium ion binding
0.48	GO:0015368	calcium:cation antiporter activity
0.46	GO:0051139	metal ion:proton antiporter activity
0.42	GO:0004531	deoxyribonuclease II activity
0.38	GO:0015386	potassium:proton antiporter activity
0.37	GO:0015081	sodium ion transmembrane transporter activity
0.33	GO:0005515	protein binding
0.33	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

0.60	GO:0005739	mitochondrion
0.43	GO:0031967	organelle envelope
0.43	GO:0031090	organelle membrane
0.37	GO:0098793	presynapse
0.30	GO:0016021	integral component of membrane

0.42

EC:3.1.22.1

GO:0004531

tr|T1EHT5|T1EHT5_HELRO
Uncharacterized protein
Search

tr|T1EHT6|T1EHT6_HELRO
Uncharacterized protein
Search

PRICKLE3

0.67	Prickle planar cell polarity protein 3

0.44	GO:0007275	multicellular organism development
0.43	GO:0030154	cell differentiation
0.42	GO:0002009	morphogenesis of an epithelium
0.41	GO:0060322	head development
0.40	GO:0016477	cell migration
0.40	GO:0008037	cell recognition
0.40	GO:0070121	Kupffer's vesicle development
0.39	GO:0030010	establishment of cell polarity
0.39	GO:0040001	establishment of mitotic spindle localization
0.39	GO:0030030	cell projection organization

0.63	GO:0008270	zinc ion binding
0.36	GO:0005515	protein binding
0.33	GO:0004222	metalloendopeptidase activity

0.46	GO:0005813	centrosome
0.41	GO:0005634	nucleus
0.36	GO:0012505	endomembrane system
0.35	GO:0005886	plasma membrane
0.34	GO:0031967	organelle envelope
0.34	GO:0005829	cytosol
0.34	GO:0031090	organelle membrane
0.34	GO:0099503	secretory vesicle
0.34	GO:0098793	presynapse
0.30	GO:0016021	integral component of membrane

0.33

GO:0004222

tr|T1EHT7|T1EHT7_HELRO
Uncharacterized protein
Search

0.78	GO:0016573	histone acetylation
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.49	GO:0018076	N-terminal peptidyl-lysine acetylation
0.48	GO:0140066	peptidyl-lysine crotonylation
0.48	GO:0140067	peptidyl-lysine butyrylation
0.48	GO:0061921	peptidyl-lysine propionylation
0.47	GO:0031648	protein destabilization
0.47	GO:0010742	macrophage derived foam cell differentiation

0.80	GO:0004402	histone acetyltransferase activity
0.75	GO:0003712	transcription cofactor activity
0.63	GO:0008270	zinc ion binding
0.48	GO:0140064	peptide crotonyltransferase activity
0.48	GO:0140065	peptide butyryltransferase activity
0.48	GO:0061920	protein propionyltransferase activity
0.47	GO:0097677	STAT family protein binding
0.47	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
0.46	GO:0001085	RNA polymerase II transcription factor binding
0.46	GO:0050681	androgen receptor binding

0.71	GO:0000123	histone acetyltransferase complex
0.40	GO:0005829	cytosol
0.40	GO:0005667	transcription factor complex
0.36	GO:0016604	nuclear body
0.36	GO:0000790	nuclear chromatin
0.34	GO:0045211	postsynaptic membrane
0.34	GO:0005852	eukaryotic translation initiation factor 3 complex
0.34	GO:0030054	cell junction
0.33	GO:0032993	protein-DNA complex
0.30	GO:0016021	integral component of membrane

0.80

GO:0004402

tr|T1EHT8|T1EHT8_HELRO
Uncharacterized protein
Search

0.44	Sulfate permease pediculus us corporis sulfate permease

0.75	GO:1902358	sulfate transmembrane transport
0.46	GO:0015701	bicarbonate transport
0.46	GO:0019532	oxalate transport
0.45	GO:0051453	regulation of intracellular pH
0.44	GO:0042391	regulation of membrane potential
0.43	GO:1902476	chloride transmembrane transport
0.35	GO:0045434	negative regulation of female receptivity, post-mating
0.33	GO:0016567	protein ubiquitination
0.32	GO:0055114	oxidation-reduction process

0.78	GO:0008271	secondary active sulfate transmembrane transporter activity
0.47	GO:0015106	bicarbonate transmembrane transporter activity
0.46	GO:0019531	oxalate transmembrane transporter activity
0.45	GO:0015301	anion:anion antiporter activity
0.44	GO:0005254	chloride channel activity
0.33	GO:0061630	ubiquitin protein ligase activity
0.33	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.33	GO:0020037	heme binding
0.33	GO:0005506	iron ion binding

0.41	GO:0005887	integral component of plasma membrane
0.38	GO:0005765	lysosomal membrane
0.36	GO:0005794	Golgi apparatus
0.36	GO:0005783	endoplasmic reticulum
0.36	GO:0005654	nucleoplasm

0.33

GO:0016705

tr|T1EHT9|T1EHT9_HELRO
Uncharacterized protein
Search

0.77	Synapsin IIa

0.82	GO:0099643	signal release from synapse
0.82	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.76	GO:0006836	neurotransmitter transport
0.72	GO:0001505	regulation of neurotransmitter levels
0.69	GO:0051649	establishment of localization in cell
0.48	GO:0097479	synaptic vesicle localization
0.37	GO:0099177	regulation of trans-synaptic signaling
0.35	GO:0071632	optomotor response
0.35	GO:1902803	regulation of synaptic vesicle transport
0.35	GO:0072553	terminal button organization

0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0019901	protein kinase binding
0.38	GO:0048306	calcium-dependent protein binding
0.37	GO:0046872	metal ion binding
0.37	GO:0003779	actin binding
0.33	GO:0046983	protein dimerization activity
0.32	GO:0005215	transporter activity

0.82	GO:0008021	synaptic vesicle
0.55	GO:0099501	exocytic vesicle membrane
0.54	GO:0014069	postsynaptic density
0.50	GO:0043209	myelin sheath
0.48	GO:0000795	synaptonemal complex
0.47	GO:0048786	presynaptic active zone
0.47	GO:0030424	axon
0.43	GO:0005856	cytoskeleton
0.40	GO:0031201	SNARE complex
0.39	GO:0030054	cell junction

tr|T1EHU0|T1EHU0_HELRO
Uncharacterized protein
Search

LOC108734332

0.65	Calcium-activated potassium channel subunit alpha-1

0.73	GO:0071804	cellular potassium ion transport
0.62	GO:0098662	inorganic cation transmembrane transport
0.34	GO:1900074	negative regulation of neuromuscular synaptic transmission
0.34	GO:0045433	male courtship behavior, veined wing generated song production
0.34	GO:0008582	regulation of synaptic growth at neuromuscular junction
0.34	GO:0048512	circadian behavior
0.33	GO:0034765	regulation of ion transmembrane transport
0.33	GO:0042493	response to drug

0.85	GO:0060072	large conductance calcium-activated potassium channel activity
0.77	GO:0005249	voltage-gated potassium channel activity
0.32	GO:0005515	protein binding
0.32	GO:0046872	metal ion binding

0.77	GO:0008076	voltage-gated potassium channel complex
0.34	GO:0043025	neuronal cell body
0.33	GO:0043005	neuron projection

tr|T1EHU1|T1EHU1_HELRO
Uncharacterized protein
Search

0.51	Calcium-activated potassium channel subunit alpha-1

0.73	GO:0071805	potassium ion transmembrane transport
0.47	GO:0034465	response to carbon monoxide
0.47	GO:0060083	smooth muscle contraction involved in micturition
0.46	GO:0045794	negative regulation of cell volume
0.45	GO:0030007	cellular potassium ion homeostasis
0.45	GO:0051592	response to calcium ion
0.44	GO:0001666	response to hypoxia
0.43	GO:0042391	regulation of membrane potential
0.43	GO:0006970	response to osmotic stress
0.43	GO:0043065	positive regulation of apoptotic process

0.85	GO:0060072	large conductance calcium-activated potassium channel activity
0.74	GO:0005249	voltage-gated potassium channel activity
0.42	GO:0003779	actin binding
0.35	GO:0004674	protein serine/threonine kinase activity
0.35	GO:0042802	identical protein binding
0.34	GO:0046872	metal ion binding
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.74	GO:0008076	voltage-gated potassium channel complex
0.45	GO:0016324	apical plasma membrane
0.44	GO:0005901	caveola
0.36	GO:0043195	terminal bouton
0.35	GO:0009897	external side of plasma membrane
0.35	GO:0070062	extracellular exosome
0.35	GO:0045211	postsynaptic membrane
0.35	GO:0005783	endoplasmic reticulum
0.33	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.33	GO:0031984	organelle subcompartment

0.35

GO:0004674

tr|T1EHU2|T1EHU2_HELRO
Uncharacterized protein
Search

0.10	Phosphatidylinositol glycan anchor biosynthesis class O

0.78	GO:0006506	GPI anchor biosynthetic process
0.34	GO:0032259	methylation
0.34	GO:0071555	cell wall organization

0.84	GO:0051377	mannose-ethanolamine phosphotransferase activity
0.34	GO:0008168	methyltransferase activity
0.34	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
0.32	GO:0016787	hydrolase activity

0.40	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0008168

tr|T1EHU3|T1EHU3_HELRO
Uncharacterized protein
Search

0.79	Glycine receptor subunit alpha-4

0.58	GO:0060079	excitatory postsynaptic potential
0.57	GO:0034220	ion transmembrane transport
0.57	GO:0006821	chloride transport
0.53	GO:0043200	response to amino acid
0.47	GO:0060012	synaptic transmission, glycinergic
0.44	GO:0007218	neuropeptide signaling pathway
0.37	GO:0045664	regulation of neuron differentiation
0.37	GO:0007417	central nervous system development
0.35	GO:0071294	cellular response to zinc ion
0.35	GO:0071361	cellular response to ethanol

0.77	GO:0016594	glycine binding
0.71	GO:0005230	extracellular ligand-gated ion channel activity
0.68	GO:0022835	transmitter-gated channel activity
0.66	GO:0004888	transmembrane signaling receptor activity
0.63	GO:0099095	ligand-gated anion channel activity
0.57	GO:0005254	chloride channel activity
0.33	GO:0008270	zinc ion binding

0.59	GO:0005887	integral component of plasma membrane
0.57	GO:0098794	postsynapse
0.50	GO:0097060	synaptic membrane
0.36	GO:0043204	perikaryon
0.36	GO:0034707	chloride channel complex
0.36	GO:0030425	dendrite
0.35	GO:0030054	cell junction

tr|T1EHU4|T1EHU4_HELRO
Uncharacterized protein
Search

SLC26A11

0.74	Sodium-independent sulfate anion transporter

0.75	GO:1902358	sulfate transmembrane transport
0.46	GO:0015701	bicarbonate transport
0.46	GO:0019532	oxalate transport
0.45	GO:0051453	regulation of intracellular pH
0.43	GO:0042391	regulation of membrane potential
0.43	GO:1902476	chloride transmembrane transport

0.78	GO:0008271	secondary active sulfate transmembrane transporter activity
0.46	GO:0015106	bicarbonate transmembrane transporter activity
0.46	GO:0019531	oxalate transmembrane transporter activity
0.45	GO:0015301	anion:anion antiporter activity
0.43	GO:0005254	chloride channel activity

0.50	GO:0005765	lysosomal membrane
0.46	GO:0005794	Golgi apparatus
0.45	GO:0005783	endoplasmic reticulum
0.45	GO:0005654	nucleoplasm
0.41	GO:0005886	plasma membrane
0.37	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

tr|T1EHU5|T1EHU5_HELRO
Uncharacterized protein
Search

0.29	Serine/threonine-protein kinase SRPK2

0.63	GO:0006468	protein phosphorylation
0.50	GO:0048026	positive regulation of mRNA splicing, via spliceosome
0.49	GO:0031658	negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
0.48	GO:0045014	negative regulation of transcription by glucose
0.48	GO:0000920	cell separation after cytokinesis
0.44	GO:0034599	cellular response to oxidative stress
0.43	GO:0000245	spliceosomal complex assembly
0.38	GO:0035556	intracellular signal transduction
0.38	GO:0051457	maintenance of protein location in nucleus
0.37	GO:0046827	positive regulation of protein export from nucleus

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0050265	RNA uridylyltransferase activity
0.35	GO:0005057	signal transducer activity, downstream of receptor
0.33	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor
0.32	GO:0038023	signaling receptor activity

0.43	GO:0005634	nucleus
0.36	GO:0032153	cell division site
0.35	GO:0005737	cytoplasm
0.33	GO:0000775	chromosome, centromeric region

0.38

EC:2.7.7.52

GO:0050265

tr|T1EHU6|T1EHU6_HELRO
Uncharacterized protein
Search

0.12	Putative e3 ubiquitin-protein ligase trim33 (Fragment)

0.63	GO:0008270	zinc ion binding
0.62	GO:0016874	ligase activity

0.45

GO:0005622

intracellular

0.62

GO:0016874

tr|T1EHU7|T1EHU7_HELRO
Uncharacterized protein
Search

tr|T1EHU8|T1EHU8_HELRO
Uncharacterized protein
Search

0.11	Putative gtp-binding protein mmr1

0.49	GO:0051168	nuclear export
0.44	GO:0042254	ribosome biogenesis
0.42	GO:0033750	ribosome localization
0.42	GO:0071428	rRNA-containing ribonucleoprotein complex export from nucleus
0.41	GO:0030437	ascospore formation
0.41	GO:0051656	establishment of organelle localization
0.41	GO:0000747	conjugation with cellular fusion
0.39	GO:0022618	ribonucleoprotein complex assembly
0.38	GO:0070925	organelle assembly
0.36	GO:0046626	regulation of insulin receptor signaling pathway

0.65	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0003924	GTPase activity
0.36	GO:0003735	structural constituent of ribosome
0.34	GO:0035091	phosphatidylinositol binding

0.54	GO:0015030	Cajal body
0.49	GO:0005829	cytosol
0.47	GO:0005783	endoplasmic reticulum
0.38	GO:0015934	large ribosomal subunit
0.30	GO:0016020	membrane

tr|T1EHU9|T1EHU9_HELRO
Uncharacterized protein
Search

DCAF5

0.75	Putative wd-repeat proteinwd-repeat protein (Fragment)

0.42	GO:0007229	integrin-mediated signaling pathway
0.41	GO:0016567	protein ubiquitination
0.41	GO:0051764	actin crosslink formation
0.40	GO:0007155	cell adhesion
0.40	GO:0043687	post-translational protein modification
0.40	GO:0051017	actin filament bundle assembly
0.37	GO:0016310	phosphorylation
0.35	GO:0016573	histone acetylation

0.39	GO:0051015	actin filament binding
0.37	GO:0016301	kinase activity
0.37	GO:0005509	calcium ion binding
0.35	GO:0004402	histone acetyltransferase activity
0.34	GO:0016787	hydrolase activity
0.34	GO:0003676	nucleic acid binding

0.77	GO:0080008	Cul4-RING E3 ubiquitin ligase complex
0.56	GO:0005739	mitochondrion
0.42	GO:0008305	integrin complex
0.38	GO:0005654	nucleoplasm

0.35

GO:0004402

tr|T1EHV0|T1EHV0_HELRO
Uncharacterized protein
Search

0.11	Serine/threonine-protein kinase SIK3 (Fragment)

0.63	GO:0006468	protein phosphorylation
0.39	GO:0042157	lipoprotein metabolic process
0.39	GO:0006869	lipid transport
0.37	GO:0001958	endochondral ossification
0.37	GO:0060351	cartilage development involved in endochondral bone morphogenesis
0.37	GO:0035264	multicellular organism growth
0.37	GO:0035108	limb morphogenesis
0.36	GO:0032880	regulation of protein localization

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0008289	lipid binding
0.37	GO:0000287	magnesium ion binding
0.36	GO:0005515	protein binding

0.43	GO:0005654	nucleoplasm
0.37	GO:0005576	extracellular region
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

tr|T1EHV1|T1EHV1_HELRO
Uncharacterized protein
Search

0.88	Glycine receptor subunit alpha-4

0.61	GO:0007165	signal transduction
0.60	GO:0034220	ion transmembrane transport
0.50	GO:0043200	response to amino acid
0.49	GO:0060078	regulation of postsynaptic membrane potential
0.48	GO:0006821	chloride transport
0.48	GO:0007268	chemical synaptic transmission
0.40	GO:0045664	regulation of neuron differentiation
0.40	GO:0007417	central nervous system development
0.34	GO:0031987	locomotion involved in locomotory behavior
0.34	GO:0060384	innervation

0.75	GO:0005230	extracellular ligand-gated ion channel activity
0.70	GO:0004888	transmembrane signaling receptor activity
0.69	GO:0016594	glycine binding
0.62	GO:0022835	transmitter-gated channel activity
0.52	GO:0099095	ligand-gated anion channel activity
0.48	GO:0005254	chloride channel activity

0.55	GO:0005887	integral component of plasma membrane
0.48	GO:0098794	postsynapse
0.38	GO:1902711	GABA-A receptor complex
0.36	GO:0097060	synaptic membrane
0.34	GO:0043204	perikaryon
0.34	GO:0034707	chloride channel complex
0.34	GO:0030425	dendrite
0.33	GO:0030054	cell junction

tr|T1EHV2|T1EHV2_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.61	GO:0007399	nervous system development
0.47	GO:0060322	head development
0.47	GO:0007267	cell-cell signaling
0.46	GO:0048513	animal organ development
0.44	GO:0050808	synapse organization
0.40	GO:0022607	cellular component assembly
0.39	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
0.38	GO:0009653	anatomical structure morphogenesis
0.37	GO:0030154	cell differentiation

0.70	GO:0005509	calcium ion binding
0.36	GO:0005515	protein binding
0.34	GO:0004930	G-protein coupled receptor activity
0.32	GO:0003700	DNA binding transcription factor activity

0.56	GO:0005886	plasma membrane
0.34	GO:0030424	axon
0.34	GO:0005911	cell-cell junction
0.34	GO:0070161	anchoring junction
0.33	GO:0070062	extracellular exosome
0.32	GO:0098562	cytoplasmic side of membrane
0.30	GO:0016021	integral component of membrane

tr|T1EHV3|T1EHV3_HELRO
Uncharacterized protein
Search

0.92	Chloride channel, voltage-sensitive 2a

0.75	GO:1902476	chloride transmembrane transport
0.39	GO:0035377	transepithelial water transport
0.39	GO:0003097	renal water transport
0.39	GO:0030321	transepithelial chloride transport

0.76	GO:0005247	voltage-gated chloride channel activity
0.33	GO:0005515	protein binding

0.39	GO:0030054	cell junction
0.38	GO:0009925	basal plasma membrane
0.37	GO:0016324	apical plasma membrane
0.35	GO:0005887	integral component of plasma membrane
0.33	GO:0005622	intracellular

tr|T1EHV4|T1EHV4_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.45	GO:0007275	multicellular organism development
0.40	GO:0016477	cell migration
0.40	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
0.40	GO:0002009	morphogenesis of an epithelium
0.40	GO:0007267	cell-cell signaling
0.39	GO:0048468	cell development
0.39	GO:0072137	condensed mesenchymal cell proliferation
0.38	GO:0120036	plasma membrane bounded cell projection organization
0.38	GO:0007605	sensory perception of sound

0.70	GO:0005509	calcium ion binding
0.35	GO:0004930	G-protein coupled receptor activity
0.35	GO:0004022	alcohol dehydrogenase (NAD) activity
0.34	GO:0050839	cell adhesion molecule binding
0.33	GO:0032403	protein complex binding

0.56	GO:0005886	plasma membrane
0.38	GO:0098858	actin-based cell projection
0.38	GO:0043005	neuron projection
0.38	GO:0032421	stereocilium bundle
0.37	GO:0045177	apical part of cell
0.36	GO:0070062	extracellular exosome
0.35	GO:0005912	adherens junction
0.35	GO:0036477	somatodendritic compartment
0.34	GO:0120038	plasma membrane bounded cell projection part
0.34	GO:0031254	cell trailing edge

0.35

EC:1.1.1.1

GO:0004022

tr|T1EHV5|T1EHV5_HELRO
One cut domain family member
Search

0.47	One cut domain family member

0.54	GO:0006351	transcription, DNA-templated
0.53	GO:1903506	regulation of nucleic acid-templated transcription
0.53	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.52	GO:0010468	regulation of gene expression
0.47	GO:0001889	liver development
0.45	GO:1902680	positive regulation of RNA biosynthetic process
0.44	GO:0030154	cell differentiation
0.40	GO:0061009	common bile duct development
0.40	GO:0031018	endocrine pancreas development
0.40	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway

0.55	GO:0003677	DNA binding
0.48	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.46	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.42	GO:0001067	regulatory region nucleic acid binding

0.58	GO:0005634	nucleus
0.39	GO:0005667	transcription factor complex
0.38	GO:0015629	actin cytoskeleton
0.37	GO:0043233	organelle lumen
0.35	GO:0044446	intracellular organelle part

tr|T1EHV6|T1EHV6_HELRO
Uncharacterized protein
Search

FGFR2

0.73	Fibroblast growth factor receptor 2 (Fragment)

0.78	GO:0008543	fibroblast growth factor receptor signaling pathway
0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.74	GO:0008284	positive regulation of cell proliferation
0.37	GO:0006915	apoptotic process
0.37	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
0.37	GO:0010518	positive regulation of phospholipase activity
0.36	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
0.36	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.36	GO:0046777	protein autophosphorylation

0.82	GO:0005007	fibroblast growth factor-activated receptor activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0017134	fibroblast growth factor binding
0.35	GO:0042802	identical protein binding
0.34	GO:0008270	zinc ion binding

0.35	GO:0030133	transport vesicle
0.35	GO:0005794	Golgi apparatus
0.35	GO:0005783	endoplasmic reticulum
0.34	GO:0005887	integral component of plasma membrane

tr|T1EHV7|T1EHV7_HELRO
Uncharacterized protein
Search

0.42	Pumilio domain containing protein

0.37	GO:0008298	intracellular mRNA localization
0.36	GO:0051646	mitochondrion localization
0.36	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
0.36	GO:0007140	male meiotic nuclear division
0.36	GO:0007005	mitochondrion organization
0.35	GO:0043409	negative regulation of MAPK cascade
0.35	GO:0007283	spermatogenesis
0.34	GO:0009060	aerobic respiration
0.33	GO:0007018	microtubule-based movement

0.59	GO:0003723	RNA binding
0.34	GO:0003777	microtubule motor activity
0.34	GO:0008017	microtubule binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.38	GO:0032473	cytoplasmic side of mitochondrial outer membrane
0.36	GO:0043186	P granule
0.35	GO:0034399	nuclear periphery
0.32	GO:0005829	cytosol

tr|T1EHV8|T1EHV8_HELRO
Uncharacterized protein
Search

PIAS1

0.92	Cell proliferation-inducing protein 23

0.59	GO:0016925	protein sumoylation
0.54	GO:0033235	positive regulation of protein sumoylation
0.51	GO:0045444	fat cell differentiation
0.51	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.49	GO:0000122	negative regulation of transcription by RNA polymerase II
0.48	GO:0042127	regulation of cell proliferation
0.40	GO:0051152	positive regulation of smooth muscle cell differentiation
0.39	GO:0008542	visual learning
0.39	GO:0000082	G1/S transition of mitotic cell cycle
0.38	GO:0007283	spermatogenesis

0.63	GO:0008270	zinc ion binding
0.60	GO:0019789	SUMO transferase activity
0.50	GO:0016874	ligase activity
0.49	GO:0031625	ubiquitin protein ligase binding
0.48	GO:0061659	ubiquitin-like protein ligase activity
0.47	GO:0008134	transcription factor binding
0.39	GO:0008022	protein C-terminus binding
0.38	GO:0019904	protein domain specific binding
0.35	GO:0003714	transcription corepressor activity
0.34	GO:0051427	hormone receptor binding

0.52	GO:0016605	PML body
0.35	GO:0016607	nuclear speck
0.30	GO:0016020	membrane

0.50

GO:0016874

tr|T1EHV9|T1EHV9_HELRO
Uncharacterized protein
Search

0.60	Cytosolic poly(ADP-ribose) glycohydrolase

0.60	GO:0005975	carbohydrate metabolic process
0.51	GO:1990966	ATP generation from poly-ADP-D-ribose
0.42	GO:0036099	female germ-line stem cell population maintenance
0.41	GO:0030576	Cajal body organization
0.41	GO:0051457	maintenance of protein location in nucleus
0.40	GO:0035065	regulation of histone acetylation
0.40	GO:0043484	regulation of RNA splicing
0.40	GO:0006342	chromatin silencing
0.39	GO:0009408	response to heat
0.36	GO:0016045	detection of bacterium

0.85	GO:0004649	poly(ADP-ribose) glycohydrolase activity
0.35	GO:0046872	metal ion binding
0.34	GO:0003682	chromatin binding

0.45	GO:0005654	nucleoplasm
0.43	GO:0005829	cytosol
0.33	GO:0000785	chromatin
0.30	GO:0016020	membrane

0.85

EC:3.2.1.143

GO:0004649

tr|T1EHW0|T1EHW0_HELRO
Uncharacterized protein
Search

0.63	GO:0006468	protein phosphorylation
0.41	GO:0071688	striated muscle myosin thick filament assembly
0.40	GO:0045214	sarcomere organization
0.40	GO:0006941	striated muscle contraction
0.38	GO:0007015	actin filament organization
0.37	GO:0043056	forward locomotion
0.37	GO:1901897	regulation of relaxation of cardiac muscle
0.37	GO:0048769	sarcomerogenesis
0.37	GO:0035995	detection of muscle stretch
0.36	GO:0048739	cardiac muscle fiber development

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0097493	structural molecule activity conferring elasticity
0.41	GO:0051371	muscle alpha-actinin binding
0.40	GO:0008307	structural constituent of muscle
0.39	GO:0051015	actin filament binding
0.37	GO:0031433	telethonin binding
0.36	GO:0030506	ankyrin binding

0.41	GO:0005859	muscle myosin complex
0.40	GO:0031430	M band
0.40	GO:0030018	Z disc
0.36	GO:0005865	striated muscle thin filament
0.35	GO:0000794	condensed nuclear chromosome
0.30	GO:0016020	membrane

tr|T1EHW1|T1EHW1_HELRO
Uncharacterized protein
Search

DYRK2

0.55	Dual specificity tyrosine-phosphorylation-regulated kinase 2

0.63	GO:0006468	protein phosphorylation
0.49	GO:0051534	negative regulation of NFAT protein import into nucleus
0.49	GO:0045725	positive regulation of glycogen biosynthetic process
0.48	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.46	GO:0007224	smoothened signaling pathway
0.44	GO:0018212	peptidyl-tyrosine modification
0.40	GO:0035617	stress granule disassembly
0.40	GO:1901796	regulation of signal transduction by p53 class mediator
0.39	GO:2001021	negative regulation of response to DNA damage stimulus
0.39	GO:0030218	erythrocyte differentiation

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0030145	manganese ion binding
0.42	GO:0000287	magnesium ion binding
0.33	GO:0005515	protein binding

0.44	GO:0000151	ubiquitin ligase complex
0.44	GO:0005654	nucleoplasm
0.43	GO:0005829	cytosol
0.40	GO:0030529	intracellular ribonucleoprotein complex
0.35	GO:0043232	intracellular non-membrane-bounded organelle

tr|T1EHW2|T1EHW2_HELRO
Uncharacterized protein
Search

0.66	Serine/threonine-protein kinase 10 (Fragment)

0.63	GO:0006468	protein phosphorylation
0.48	GO:0007091	metaphase/anaphase transition of mitotic cell cycle
0.47	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
0.46	GO:0000132	establishment of mitotic spindle orientation
0.45	GO:0030866	cortical actin cytoskeleton organization
0.45	GO:0007052	mitotic spindle organization
0.45	GO:0000281	mitotic cytokinesis
0.45	GO:0008283	cell proliferation
0.43	GO:0000902	cell morphogenesis
0.42	GO:0032879	regulation of localization

0.69	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0005057	signal transducer activity, downstream of receptor
0.34	GO:0016907	G-protein coupled acetylcholine receptor activity
0.34	GO:0004499	N,N-dimethylaniline monooxygenase activity
0.34	GO:0003735	structural constituent of ribosome
0.33	GO:0050662	coenzyme binding
0.33	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

0.46	GO:0032154	cleavage furrow
0.46	GO:1990023	mitotic spindle midzone
0.43	GO:0005938	cell cortex
0.35	GO:0015934	large ribosomal subunit
0.33	GO:0005887	integral component of plasma membrane

0.69

GO:0004674

tr|T1EHW3|T1EHW3_HELRO
Uncharacterized protein
Search

CERS5

0.83	Ceramide synthase 5

0.53

GO:0046513

ceramide biosynthetic process

0.55	GO:0050291	sphingosine N-acyltransferase activity
0.53	GO:0003677	DNA binding

0.59	GO:0005634	nucleus
0.47	GO:0005783	endoplasmic reticulum
0.35	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.35	GO:0031984	organelle subcompartment
0.34	GO:0031967	organelle envelope
0.34	GO:0031090	organelle membrane
0.30	GO:0044425	membrane part

0.55

EC:2.3.1.24

GO:0050291

tr|T1EHW4|T1EHW4_HELRO
Uncharacterized protein
Search

0.55	Cyclin dependent kinase like 2

0.63	GO:0006468	protein phosphorylation
0.46	GO:0051726	regulation of cell cycle
0.34	GO:1903955	positive regulation of protein targeting to mitochondrion
0.34	GO:0007548	sex differentiation
0.33	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
0.33	GO:0044205	'de novo' UMP biosynthetic process
0.33	GO:0007165	signal transduction
0.33	GO:0043043	peptide biosynthetic process
0.32	GO:0010467	gene expression
0.32	GO:0009059	macromolecule biosynthetic process

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0060089	molecular transducer activity
0.34	GO:0004588	orotate phosphoribosyltransferase activity
0.34	GO:0004590	orotidine-5'-phosphate decarboxylase activity
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0003677	DNA binding

0.48	GO:0005813	centrosome
0.45	GO:0005634	nucleus
0.34	GO:0005737	cytoplasm
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0016020	membrane

0.34	EC:2.4.2.10	GO:0004588
0.34	KEGG:R00965	GO:0004590

tr|T1EHW5|T1EHW5_HELRO
Uncharacterized protein
Search

0.61	GO:0007165	signal transduction
0.60	GO:0034220	ion transmembrane transport
0.59	GO:0060078	regulation of postsynaptic membrane potential
0.58	GO:0007268	chemical synaptic transmission
0.37	GO:1902656	calcium ion import into cytosol
0.37	GO:0098739	import across plasma membrane
0.36	GO:0006937	regulation of muscle contraction

0.76	GO:0005230	extracellular ligand-gated ion channel activity
0.70	GO:0004888	transmembrane signaling receptor activity
0.61	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
0.57	GO:0022835	transmitter-gated channel activity
0.56	GO:0140135	mechanosensitive cation channel activity
0.38	GO:0005509	calcium ion binding
0.35	GO:0042302	structural constituent of cuticle

0.59	GO:0045211	postsynaptic membrane
0.55	GO:0030054	cell junction
0.30	GO:0016021	integral component of membrane

tr|T1EHW6|T1EHW6_HELRO
Uncharacterized protein
Search

SUV39H2

0.44	Histone-lysine N-methyltransferase

0.79	GO:0034968	histone lysine methylation
0.49	GO:0061647	histone H3-K9 modification
0.45	GO:0006333	chromatin assembly or disassembly
0.44	GO:0006338	chromatin remodeling
0.44	GO:0045892	negative regulation of transcription, DNA-templated
0.43	GO:2001229	negative regulation of response to gamma radiation
0.43	GO:0034401	chromatin organization involved in regulation of transcription
0.43	GO:0070828	heterochromatin organization
0.43	GO:0048132	female germ-line stem cell asymmetric division
0.42	GO:0071456	cellular response to hypoxia

0.79	GO:0018024	histone-lysine N-methyltransferase activity
0.63	GO:0008270	zinc ion binding
0.44	GO:0003924	GTPase activity
0.43	GO:0032550	purine ribonucleoside binding
0.43	GO:0032561	guanyl ribonucleotide binding
0.41	GO:1904047	S-adenosyl-L-methionine binding
0.39	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0003743	translation initiation factor activity
0.36	GO:0035064	methylated histone binding
0.35	GO:0003727	single-stranded RNA binding

0.67	GO:0005694	chromosome
0.61	GO:0005634	nucleus
0.39	GO:0044446	intracellular organelle part
0.36	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex
0.35	GO:0034708	methyltransferase complex
0.34	GO:0043233	organelle lumen
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:2.1.1.43

GO:0018024

tr|T1EHW7|T1EHW7_HELRO
Uncharacterized protein
Search

tr|T1EHW8|T1EHW8_HELRO
Uncharacterized protein
Search

0.76	GO:0051056	regulation of small GTPase mediated signal transduction
0.76	GO:0043547	positive regulation of GTPase activity
0.45	GO:0008361	regulation of cell size
0.44	GO:0010977	negative regulation of neuron projection development
0.34	GO:0048814	regulation of dendrite morphogenesis
0.33	GO:0031532	actin cytoskeleton reorganization
0.32	GO:0035556	intracellular signal transduction

0.76	GO:0005096	GTPase activator activity
0.33	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.45	GO:0031965	nuclear membrane
0.44	GO:0005813	centrosome
0.42	GO:0043005	neuron projection
0.42	GO:0005829	cytosol
0.38	GO:0005886	plasma membrane
0.34	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0031224	intrinsic component of membrane

tr|T1EHW9|T1EHW9_HELRO
Uncharacterized protein
Search

MCRS1

0.89	Microspherule protein 1

0.57	GO:1904751	positive regulation of protein localization to nucleolus
0.56	GO:0043982	histone H4-K8 acetylation
0.56	GO:0043981	histone H4-K5 acetylation
0.55	GO:0043984	histone H4-K16 acetylation
0.42	GO:0010842	retina layer formation
0.41	GO:0070925	organelle assembly
0.41	GO:0044782	cilium organization
0.41	GO:0120031	plasma membrane bounded cell projection assembly
0.40	GO:0051974	negative regulation of telomerase activity
0.40	GO:1904357	negative regulation of telomere maintenance via telomere lengthening

0.85	GO:0002151	G-quadruplex RNA binding
0.56	GO:0034046	poly(G) binding
0.56	GO:0043996	histone acetyltransferase activity (H4-K8 specific)
0.56	GO:0046972	histone acetyltransferase activity (H4-K16 specific)
0.56	GO:0043995	histone acetyltransferase activity (H4-K5 specific)
0.54	GO:0008266	poly(U) RNA binding
0.40	GO:0010521	telomerase inhibitor activity
0.34	GO:0005515	protein binding
0.34	GO:0005543	phospholipid binding
0.33	GO:0050660	flavin adenine dinucleotide binding

0.82	GO:0071339	MLL1 complex
0.79	GO:0031011	Ino80 complex
0.51	GO:0000123	histone acetyltransferase complex
0.49	GO:0005730	nucleolus
0.39	GO:0005705	polytene chromosome interband
0.39	GO:0005844	polysome
0.39	GO:0030425	dendrite
0.39	GO:0043204	perikaryon
0.38	GO:0005737	cytoplasm
0.37	GO:0012505	endomembrane system

0.33

EC:1.1

GO:0016614

tr|T1EHX0|T1EHX0_HELRO
Uncharacterized protein
Search

0.86	Musashi RNA-binding protein 2a

0.39	GO:0048576	positive regulation of short-day photoperiodism, flowering
0.38	GO:0048578	positive regulation of long-day photoperiodism, flowering
0.37	GO:0006378	mRNA polyadenylation
0.34	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.34	GO:0006754	ATP biosynthetic process
0.34	GO:0006338	chromatin remodeling
0.34	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.33	GO:0006030	chitin metabolic process
0.32	GO:0005975	carbohydrate metabolic process

0.59	GO:0003723	RNA binding
0.34	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
0.33	GO:0008061	chitin binding
0.33	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
0.33	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.32	GO:0003677	DNA binding
0.32	GO:0046872	metal ion binding

0.49	GO:0019013	viral nucleocapsid
0.44	GO:0030529	intracellular ribonucleoprotein complex
0.35	GO:0005829	cytosol
0.34	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)
0.34	GO:0070603	SWI/SNF superfamily-type complex
0.33	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

0.33

EC:3.5

GO:0016810

tr|T1EHX1|T1EHX1_HELRO
Uncharacterized protein
Search

0.37	Serine/threonine protein kinase

0.63	GO:0006468	protein phosphorylation
0.48	GO:0030252	growth hormone secretion
0.47	GO:0002168	instar larval development
0.47	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
0.46	GO:0001700	embryonic development via the syncytial blastoderm
0.46	GO:0051726	regulation of cell cycle
0.46	GO:0007552	metamorphosis
0.45	GO:0048589	developmental growth
0.45	GO:0031175	neuron projection development
0.44	GO:0002009	morphogenesis of an epithelium

0.64	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0097472	cyclin-dependent protein kinase activity
0.50	GO:0020037	heme binding
0.49	GO:0030332	cyclin binding
0.34	GO:0042813	Wnt-activated receptor activity
0.32	GO:0046872	metal ion binding

0.46	GO:0005829	cytosol
0.46	GO:0008021	synaptic vesicle
0.45	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.43	GO:0015630	microtubule cytoskeleton
0.41	GO:0000308	cytoplasmic cyclin-dependent protein kinase holoenzyme complex
0.40	GO:0005634	nucleus
0.33	GO:0043005	neuron projection
0.33	GO:0030054	cell junction
0.30	GO:0016021	integral component of membrane

0.64

GO:0004674

tr|T1EHX2|T1EHX2_HELRO
Uncharacterized protein
Search

0.53	GO:0055114	oxidation-reduction process
0.44	GO:0008202	steroid metabolic process
0.43	GO:0010817	regulation of hormone levels
0.40	GO:0042180	cellular ketone metabolic process
0.39	GO:0008610	lipid biosynthetic process
0.38	GO:0001523	retinoid metabolic process
0.38	GO:0009410	response to xenobiotic stimulus
0.37	GO:0034308	primary alcohol metabolic process
0.37	GO:0017144	drug metabolic process
0.36	GO:1901362	organic cyclic compound biosynthetic process

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.65	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.44	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity
0.36	GO:0005496	steroid binding
0.34	GO:0019825	oxygen binding
0.33	GO:0004866	endopeptidase inhibitor activity
0.32	GO:0003924	GTPase activity
0.32	GO:0005525	GTP binding

0.41	GO:0043025	neuronal cell body
0.40	GO:0030424	axon
0.37	GO:0043231	intracellular membrane-bounded organelle
0.36	GO:0044444	cytoplasmic part
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0031984	organelle subcompartment
0.34	GO:0031090	organelle membrane
0.33	GO:0005901	caveola
0.33	GO:0009986	cell surface
0.33	GO:0005615	extracellular space

0.68

GO:0016705

tr|T1EHX3|T1EHX3_HELRO
Uncharacterized protein
Search

0.12	Putative helicase MOV-10

0.41

GO:0035279

mRNA cleavage involved in gene silencing by miRNA

0.65	GO:0004386	helicase activity
0.35	GO:0008270	zinc ion binding
0.35	GO:0003676	nucleic acid binding

0.39	GO:0000932	P-body
0.37	GO:0005829	cytosol

tr|T1EHX4|T1EHX4_HELRO
Uncharacterized protein
Search

0.70	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
0.54	GO:0006396	RNA processing
0.53	GO:1901409	positive regulation of phosphorylation of RNA polymerase II C-terminal domain
0.51	GO:1904031	positive regulation of cyclin-dependent protein kinase activity
0.49	GO:0071902	positive regulation of protein serine/threonine kinase activity
0.49	GO:0045787	positive regulation of cell cycle
0.47	GO:0045944	positive regulation of transcription by RNA polymerase II
0.36	GO:0006351	transcription, DNA-templated
0.34	GO:0045862	positive regulation of proteolysis
0.33	GO:0043043	peptide biosynthetic process

0.50	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.36	GO:0005515	protein binding
0.33	GO:0003735	structural constituent of ribosome

0.60	GO:0005634	nucleus
0.51	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
0.45	GO:0043233	organelle lumen
0.41	GO:0044446	intracellular organelle part
0.33	GO:0044444	cytoplasmic part
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0043232	intracellular non-membrane-bounded organelle

0.50

GO:0016538

tr|T1EHX5|T1EHX5_HELRO
Uncharacterized protein
Search

MANEA

0.94	Mannosidase endo-alpha like

0.30

GO:0008152

metabolic process

0.66	GO:0016798	hydrolase activity, acting on glycosyl bonds
0.32	GO:0003676	nucleic acid binding

0.48	GO:0005794	Golgi apparatus
0.38	GO:0098588	bounding membrane of organelle
0.37	GO:0031984	organelle subcompartment
0.30	GO:0044425	membrane part

0.66

EC:3.2

GO:0016798

tr|T1EHX6|T1EHX6_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.42	GO:0007399	nervous system development
0.41	GO:0007267	cell-cell signaling
0.37	GO:0050808	synapse organization
0.36	GO:0060322	head development
0.36	GO:0048513	animal organ development
0.35	GO:0001838	embryonic epithelial tube formation
0.35	GO:0007600	sensory perception
0.35	GO:0022607	cellular component assembly
0.35	GO:0043009	chordate embryonic development

0.70	GO:0005509	calcium ion binding
0.34	GO:0042803	protein homodimerization activity
0.34	GO:0060089	molecular transducer activity
0.34	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.33	GO:0004022	alcohol dehydrogenase (NAD) activity
0.33	GO:0004871	signal transducer activity
0.33	GO:0004725	protein tyrosine phosphatase activity
0.33	GO:0008233	peptidase activity
0.33	GO:0004867	serine-type endopeptidase inhibitor activity

0.56	GO:0005886	plasma membrane
0.34	GO:0005615	extracellular space
0.33	GO:0032420	stereocilium
0.30	GO:0016021	integral component of membrane

0.34

EC:2.7.11.23

GO:0008353

tr|T1EHX7|T1EHX7_HELRO
Uncharacterized protein
Search

0.10	ATP-dependent RNA helicase DDX42-like protein (Fragment)

0.49	GO:0042981	regulation of apoptotic process
0.46	GO:0010501	RNA secondary structure unwinding
0.45	GO:0008104	protein localization
0.34	GO:0000398	mRNA splicing, via spliceosome

0.61	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.44	GO:0008186	RNA-dependent ATPase activity
0.40	GO:0140098	catalytic activity, acting on RNA
0.33	GO:0005515	protein binding

0.51	GO:0016607	nuclear speck
0.46	GO:0005829	cytosol
0.43	GO:0005730	nucleolus
0.37	GO:0015030	Cajal body
0.30	GO:0016020	membrane

tr|T1EHX8|T1EHX8_HELRO
Uncharacterized protein
Search

0.43	Muscarinic acetylcholine receptor

0.83	GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
0.66	GO:0046541	saliva secretion
0.57	GO:0050890	cognition
0.54	GO:0040012	regulation of locomotion
0.49	GO:0045987	positive regulation of smooth muscle contraction
0.44	GO:0003056	regulation of vascular smooth muscle contraction
0.44	GO:0001696	gastric acid secretion
0.43	GO:0007271	synaptic transmission, cholinergic
0.43	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.43	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway

0.84

GO:0016907

G-protein coupled acetylcholine receptor activity

0.65	GO:0005887	integral component of plasma membrane
0.53	GO:0045211	postsynaptic membrane
0.51	GO:0030054	cell junction

tr|T1EHX9|T1EHX9_HELRO
Uncharacterized protein
Search

0.68	Histone acetyltransferase MYST3 (Fragment)

0.35	GO:0070647	protein modification by small protein conjugation or removal
0.34	GO:0007186	G-protein coupled receptor signaling pathway
0.34	GO:0036159	inner dynein arm assembly
0.34	GO:0006270	DNA replication initiation
0.34	GO:0003341	cilium movement
0.33	GO:0048208	COPII vesicle coating
0.33	GO:0006508	proteolysis
0.33	GO:0006030	chitin metabolic process
0.33	GO:0006313	transposition, DNA-mediated
0.33	GO:0015074	DNA integration

0.34	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.34	GO:0045503	dynein light chain binding
0.34	GO:0004842	ubiquitin-protein transferase activity
0.34	GO:0017076	purine nucleotide binding
0.34	GO:0031683	G-protein beta/gamma-subunit complex binding
0.34	GO:0051959	dynein light intermediate chain binding
0.34	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed
0.34	GO:0045505	dynein intermediate chain binding
0.34	GO:0097367	carbohydrate derivative binding
0.34	GO:0008144	drug binding

0.34	GO:0036156	inner dynein arm
0.33	GO:0043231	intracellular membrane-bounded organelle
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0030008	TRAPP complex
0.32	GO:0031984	organelle subcompartment
0.32	GO:0012505	endomembrane system
0.32	GO:0098805	whole membrane
0.32	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

0.34	EC:3.6.4.5	GO:0008569
0.34	KEGG:R03876	GO:0004842

tr|T1EHY0|T1EHY0_HELRO
Uncharacterized protein
Search

KDM4A

0.80	JmjC domain-containing histone demethylation protein 3C

0.47	GO:0032259	methylation
0.47	GO:0070544	histone H3-K36 demethylation
0.46	GO:0033169	histone H3-K9 demethylation
0.40	GO:0010628	positive regulation of gene expression
0.36	GO:0048514	blood vessel morphogenesis
0.34	GO:0006508	proteolysis
0.34	GO:0045892	negative regulation of transcription, DNA-templated
0.34	GO:0046856	phosphatidylinositol dephosphorylation
0.34	GO:0055114	oxidation-reduction process
0.33	GO:0006351	transcription, DNA-templated

0.48	GO:0008168	methyltransferase activity
0.47	GO:0051864	histone demethylase activity (H3-K36 specific)
0.46	GO:0032454	histone demethylase activity (H3-K9 specific)
0.44	GO:0046872	metal ion binding
0.37	GO:0003676	nucleic acid binding
0.37	GO:0004181	metallocarboxypeptidase activity
0.34	GO:0019706	protein-cysteine S-palmitoyltransferase activity

0.61	GO:0005634	nucleus
0.42	GO:0000792	heterochromatin
0.30	GO:0016020	membrane

0.48

GO:0008168

tr|T1EHY1|T1EHY1_HELRO
Uncharacterized protein
Search

NIM1K

0.96	Serine/threonine-protein kinase NIM1

0.63	GO:0006468	protein phosphorylation
0.42	GO:0035556	intracellular signal transduction
0.39	GO:0030010	establishment of cell polarity
0.38	GO:0000226	microtubule cytoskeleton organization
0.33	GO:0071805	potassium ion transmembrane transport

0.67	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0000287	magnesium ion binding
0.34	GO:0060072	large conductance calcium-activated potassium channel activity

0.41	GO:0005634	nucleus
0.37	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.67

GO:0004674

tr|T1EHY2|T1EHY2_HELRO
Uncharacterized protein
Search

0.50	Rhabdomeric opsin

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.70	GO:0007602	phototransduction
0.68	GO:0007601	visual perception
0.65	GO:0018298	protein-chromophore linkage
0.38	GO:0009584	detection of visible light
0.36	GO:0006937	regulation of muscle contraction
0.35	GO:0095500	acetylcholine receptor signaling pathway
0.32	GO:0072321	chaperone-mediated protein transport
0.32	GO:0045039	protein import into mitochondrial inner membrane
0.32	GO:0006508	proteolysis

0.72	GO:0004930	G-protein coupled receptor activity
0.69	GO:0009881	photoreceptor activity
0.42	GO:0001653	peptide receptor activity
0.35	GO:0015464	acetylcholine receptor activity
0.34	GO:0016500	protein-hormone receptor activity
0.32	GO:0004252	serine-type endopeptidase activity
0.32	GO:0008565	protein transporter activity

0.34	GO:0005887	integral component of plasma membrane
0.34	GO:0001750	photoreceptor outer segment
0.32	GO:0042719	mitochondrial intermembrane space protein transporter complex
0.32	GO:0042721	mitochondrial inner membrane protein insertion complex

0.32

GO:0004252

tr|T1EHY3|T1EHY3_HELRO
Uncharacterized protein
Search

CYTH3

0.80	GTP exchange factor for ARFs 1 (inferred by orthology to a C. elegans protein)

0.81	GO:0032012	regulation of ARF protein signal transduction
0.66	GO:0065009	regulation of molecular function
0.46	GO:0090162	establishment of epithelial cell polarity
0.45	GO:0048193	Golgi vesicle transport
0.43	GO:0030155	regulation of cell adhesion
0.41	GO:0048518	positive regulation of biological process
0.41	GO:0000045	autophagosome assembly
0.38	GO:0046907	intracellular transport
0.33	GO:0050482	arachidonic acid secretion
0.33	GO:0016042	lipid catabolic process

0.82	GO:0005086	ARF guanyl-nucleotide exchange factor activity
0.46	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.33	GO:0005230	extracellular ligand-gated ion channel activity
0.33	GO:0004623	phospholipase A2 activity
0.33	GO:0004888	transmembrane signaling receptor activity
0.32	GO:0005509	calcium ion binding

0.45	GO:0001726	ruffle
0.44	GO:0005923	bicellular tight junction
0.44	GO:0005912	adherens junction
0.43	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.43	GO:0005829	cytosol
0.41	GO:0005802	trans-Golgi network
0.41	GO:0005654	nucleoplasm
0.40	GO:0005770	late endosome
0.40	GO:0005798	Golgi-associated vesicle
0.34	GO:0000139	Golgi membrane

0.33

EC:3.1.1.4

GO:0004623

tr|T1EHY4|T1EHY4_HELRO
Uncharacterized protein
Search

0.80

GO:0046580

negative regulation of Ras protein signal transduction

0.30

GO:0031224

intrinsic component of membrane

tr|T1EHY5|T1EHY5_HELRO
Uncharacterized protein
Search

tr|T1EHY6|T1EHY6_HELRO
Uncharacterized protein
Search

TRMT11

0.75	tRNA methyltransferase 11 homolog

0.63	GO:0032259	methylation
0.37	GO:0008033	tRNA processing
0.35	GO:0009451	RNA modification
0.33	GO:0006511	ubiquitin-dependent protein catabolic process
0.33	GO:0007275	multicellular organism development

0.63	GO:0008168	methyltransferase activity
0.51	GO:0003676	nucleic acid binding
0.35	GO:0140101	catalytic activity, acting on a tRNA
0.32	GO:0046872	metal ion binding
0.32	GO:0016787	hydrolase activity

0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.63

GO:0008168

tr|T1EHY7|T1EHY7_HELRO
Uncharacterized protein
Search

0.91	Beta-site APP cleaving enzyme (Fragment)

0.61	GO:0006508	proteolysis
0.60	GO:0050435	amyloid-beta metabolic process
0.54	GO:0050804	modulation of chemical synaptic transmission
0.44	GO:0030163	protein catabolic process
0.35	GO:0031643	positive regulation of myelination
0.35	GO:0022011	myelination in peripheral nervous system
0.35	GO:0007613	memory
0.33	GO:0065008	regulation of biological quality
0.32	GO:0044267	cellular protein metabolic process

0.70	GO:0070001	aspartic-type peptidase activity
0.65	GO:0004175	endopeptidase activity
0.58	GO:0001540	amyloid-beta binding
0.50	GO:0019899	enzyme binding
0.35	GO:0008798	beta-aspartyl-peptidase activity

0.57	GO:0005771	multivesicular body
0.54	GO:0005769	early endosome
0.54	GO:0005802	trans-Golgi network
0.54	GO:0030424	axon
0.48	GO:0005887	integral component of plasma membrane
0.39	GO:0045121	membrane raft
0.38	GO:0030659	cytoplasmic vesicle membrane
0.38	GO:0009986	cell surface
0.37	GO:0005783	endoplasmic reticulum
0.36	GO:0070931	Golgi-associated vesicle lumen

0.35

EC:3.4.19.5

GO:0008798

tr|T1EHY8|T1EHY8_HELRO
Uncharacterized protein
Search

EXOSC9

0.83	Exosome component 9

0.62	GO:0006396	RNA processing
0.58	GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process
0.54	GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
0.54	GO:0071028	nuclear mRNA surveillance
0.52	GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process
0.51	GO:0030307	positive regulation of cell growth
0.50	GO:0016073	snRNA metabolic process
0.48	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
0.47	GO:0071047	polyadenylation-dependent mRNA catabolic process
0.46	GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'

0.54	GO:0017091	AU-rich element binding
0.44	GO:0004527	exonuclease activity
0.36	GO:0001102	RNA polymerase II activating transcription factor binding
0.33	GO:0004540	ribonuclease activity

0.79	GO:0000178	exosome (RNase complex)
0.51	GO:0005730	nucleolus
0.47	GO:0000228	nuclear chromosome
0.46	GO:0005654	nucleoplasm
0.40	GO:0044444	cytoplasmic part
0.34	GO:0070062	extracellular exosome
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1EHY9|T1EHY9_HELRO
Uncharacterized protein
Search

0.93	Conopressin receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.53	GO:0048016	inositol phosphate-mediated signaling
0.52	GO:0019722	calcium-mediated signaling
0.43	GO:0008217	regulation of blood pressure
0.42	GO:0045907	positive regulation of vasoconstriction
0.42	GO:1901652	response to peptide
0.41	GO:0050886	endocrine process
0.41	GO:0032870	cellular response to hormone stimulus
0.36	GO:0048848	neurohypophysis morphogenesis
0.34	GO:0046887	positive regulation of hormone secretion

0.85	GO:0005000	vasopressin receptor activity
0.71	GO:0004990	oxytocin receptor activity
0.53	GO:0017046	peptide hormone binding
0.37	GO:0016500	protein-hormone receptor activity
0.33	GO:0016907	G-protein coupled acetylcholine receptor activity

0.50	GO:0005886	plasma membrane
0.36	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

tr|T1EHZ0|T1EHZ0_HELRO
Uncharacterized protein
Search

0.38	GO:0048699	generation of neurons
0.38	GO:0051247	positive regulation of protein metabolic process
0.38	GO:0043408	regulation of MAPK cascade
0.38	GO:0051347	positive regulation of transferase activity
0.37	GO:0045859	regulation of protein kinase activity
0.37	GO:0016192	vesicle-mediated transport
0.37	GO:0048522	positive regulation of cellular process
0.37	GO:0048584	positive regulation of response to stimulus
0.37	GO:0098657	import into cell
0.37	GO:2000026	regulation of multicellular organismal development

0.65	GO:0005509	calcium ion binding
0.39	GO:0030229	very-low-density lipoprotein particle receptor activity
0.38	GO:0005201	extracellular matrix structural constituent
0.37	GO:0004252	serine-type endopeptidase activity
0.37	GO:0001540	amyloid-beta binding
0.37	GO:0030169	low-density lipoprotein particle binding
0.37	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.35	GO:0030306	ADP-ribosylation factor binding
0.35	GO:0005041	low-density lipoprotein receptor activity
0.34	GO:0002020	protease binding

0.40	GO:0043235	receptor complex
0.39	GO:0044421	extracellular region part
0.37	GO:0031410	cytoplasmic vesicle
0.36	GO:0098589	membrane region
0.36	GO:0012505	endomembrane system
0.36	GO:0098590	plasma membrane region
0.35	GO:0097458	neuron part
0.35	GO:1990666	PCSK9-LDLR complex
0.35	GO:0009897	external side of plasma membrane
0.35	GO:0045177	apical part of cell

0.37

GO:0004252

tr|T1EHZ1|T1EHZ1_HELRO
Uncharacterized protein
Search

0.52	GO:0055114	oxidation-reduction process
0.36	GO:0006633	fatty acid biosynthetic process
0.33	GO:1901440	poly(hydroxyalkanoate) metabolic process

0.53	GO:0016491	oxidoreductase activity
0.38	GO:0004312	fatty acid synthase activity
0.35	GO:0051287	NAD binding

0.31	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

0.53

GO:0016491

tr|T1EHZ2|T1EHZ2_HELRO
Uncharacterized protein
Search

0.51	ATP-binding cassette sub-family A member 3

0.54	GO:0055085	transmembrane transport
0.49	GO:0060155	platelet dense granule organization
0.48	GO:0038027	apolipoprotein A-I-mediated signaling pathway
0.48	GO:0050702	interleukin-1 beta secretion
0.48	GO:0032489	regulation of Cdc42 protein signal transduction
0.48	GO:0034380	high-density lipoprotein particle assembly
0.48	GO:0034616	response to laminar fluid shear stress
0.48	GO:0033700	phospholipid efflux
0.47	GO:0055091	phospholipid homeostasis
0.47	GO:0010875	positive regulation of cholesterol efflux

0.64	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0090556	phosphatidylserine-translocating ATPase activity
0.49	GO:0034188	apolipoprotein A-I receptor activity
0.48	GO:0090554	phosphatidylcholine-translocating ATPase activity
0.48	GO:0034186	apolipoprotein A-I binding
0.47	GO:0017127	cholesterol transporter activity

0.46	GO:0045335	phagocytic vesicle
0.45	GO:0009897	external side of plasma membrane
0.45	GO:0098857	membrane microdomain
0.44	GO:0048471	perinuclear region of cytoplasm
0.42	GO:0005794	Golgi apparatus
0.41	GO:0005887	integral component of plasma membrane
0.36	GO:0034364	high-density lipoprotein particle
0.35	GO:0005783	endoplasmic reticulum
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.34	GO:0031984	organelle subcompartment

tr|T1EHZ3|T1EHZ3_HELRO
Uncharacterized protein
Search

tr|T1EHZ4|T1EHZ4_HELRO
Uncharacterized protein
Search

0.81	GO:0060038	cardiac muscle cell proliferation
0.77	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling
0.39	GO:0048199	vesicle targeting, to, from or within Golgi

0.74	GO:0030137	COPI-coated vesicle
0.70	GO:0030120	vesicle coat
0.70	GO:0030660	Golgi-associated vesicle membrane
0.67	GO:0005615	extracellular space
0.66	GO:0044431	Golgi apparatus part
0.60	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

tr|T1EHZ5|T1EHZ5_HELRO
Innexin
Search

INX

0.44

Innexin

0.58	GO:0006811	ion transport
0.37	GO:0048598	embryonic morphogenesis
0.35	GO:0010644	cell communication by electrical coupling
0.34	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0055085	transmembrane transport
0.32	GO:0033674	positive regulation of kinase activity
0.32	GO:0045859	regulation of protein kinase activity
0.32	GO:0006417	regulation of translation
0.32	GO:0033554	cellular response to stress

0.37	GO:0005243	gap junction channel activity
0.34	GO:0004930	G-protein coupled receptor activity
0.33	GO:0019887	protein kinase regulator activity
0.33	GO:0019901	protein kinase binding
0.32	GO:0043022	ribosome binding

0.81	GO:0005921	gap junction
0.55	GO:0005886	plasma membrane
0.34	GO:0045202	synapse
0.33	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

tr|T1EHZ6|T1EHZ6_HELRO
Innexin
Search

INX

0.48	Innexin unc-9

0.59	GO:0006811	ion transport
0.36	GO:0048598	embryonic morphogenesis
0.35	GO:0010644	cell communication by electrical coupling
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.32	GO:0055085	transmembrane transport

0.35	GO:0005243	gap junction channel activity
0.34	GO:0004930	G-protein coupled receptor activity

0.81	GO:0005921	gap junction
0.56	GO:0005886	plasma membrane
0.34	GO:0045202	synapse
0.33	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

tr|T1EHZ7|T1EHZ7_HELRO
Palmitoyltransferase
Search

0.37	Palmitoyltransferase

0.57	GO:0018345	protein palmitoylation
0.35	GO:1903146	regulation of autophagy of mitochondrion
0.35	GO:1903955	positive regulation of protein targeting to mitochondrion

0.80	GO:0019707	protein-cysteine S-acyltransferase activity
0.79	GO:0016409	palmitoyltransferase activity
0.33	GO:0005515	protein binding

0.50	GO:0030425	dendrite
0.41	GO:0005886	plasma membrane
0.36	GO:0005737	cytoplasm
0.35	GO:0012505	endomembrane system
0.34	GO:0043227	membrane-bounded organelle
0.33	GO:0043229	intracellular organelle
0.30	GO:0016021	integral component of membrane

0.80

GO:0019707

tr|T1EHZ8|T1EHZ8_HELRO
Uncharacterized protein
Search

0.54	pleckstrin homology-like domain family B member 1

0.87	GO:1904261	positive regulation of basement membrane assembly involved in embryonic body morphogenesis
0.85	GO:0010470	regulation of gastrulation
0.84	GO:0010717	regulation of epithelial to mesenchymal transition
0.79	GO:0070507	regulation of microtubule cytoskeleton organization
0.38	GO:0015031	protein transport

0.86	GO:0045180	basal cortex
0.30	GO:0016020	membrane

tr|T1EHZ9|T1EHZ9_HELRO
Uncharacterized protein
Search

tr|T1EI00|T1EI00_HELRO
Uncharacterized protein
Search

tr|T1EI01|T1EI01_HELRO
Kinesin-like protein
Search

0.74	GO:0007018	microtubule-based movement
0.44	GO:1903047	mitotic cell cycle process
0.43	GO:0051310	metaphase plate congression
0.43	GO:0000280	nuclear division
0.42	GO:0051726	regulation of cell cycle
0.41	GO:0000819	sister chromatid segregation
0.39	GO:0051983	regulation of chromosome segregation
0.39	GO:0051783	regulation of nuclear division
0.39	GO:0010245	radial microtubular system formation
0.39	GO:0033044	regulation of chromosome organization

0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0016887	ATPase activity
0.37	GO:0043515	kinetochore binding
0.35	GO:0015299	solute:proton antiporter activity
0.33	GO:0004871	signal transducer activity
0.33	GO:0016874	ligase activity

0.54	GO:0015630	microtubule cytoskeleton
0.53	GO:0044430	cytoskeletal part
0.53	GO:0099512	supramolecular fiber
0.42	GO:0000776	kinetochore
0.40	GO:0000779	condensed chromosome, centromeric region
0.37	GO:0055044	symplast
0.37	GO:0005911	cell-cell junction
0.36	GO:0030496	midbody
0.35	GO:0005654	nucleoplasm
0.35	GO:0005829	cytosol

0.40

GO:0016887

tr|T1EI02|T1EI02_HELRO
Uncharacterized protein
Search

0.54	GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation
0.53	GO:2000320	negative regulation of T-helper 17 cell differentiation
0.47	GO:0010628	positive regulation of gene expression
0.47	GO:0006366	transcription by RNA polymerase II
0.47	GO:0051254	positive regulation of RNA metabolic process
0.46	GO:0010557	positive regulation of macromolecule biosynthetic process
0.46	GO:0031328	positive regulation of cellular biosynthetic process
0.45	GO:0006357	regulation of transcription by RNA polymerase II
0.44	GO:0010629	negative regulation of gene expression
0.37	GO:0007275	multicellular organism development

0.51	GO:0003676	nucleic acid binding
0.49	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.47	GO:0042803	protein homodimerization activity
0.38	GO:0046872	metal ion binding
0.35	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0004609	phosphatidylserine decarboxylase activity

0.45	GO:0005654	nucleoplasm
0.35	GO:0031305	integral component of mitochondrial inner membrane

0.35	EC:4.1.1.65	GO:0004609
0.35	KEGG:R02055	GO:0004609

tr|T1EI03|T1EI03_HELRO
Uncharacterized protein
Search

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.41	GO:0007600	sensory perception
0.41	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.41	GO:2000252	negative regulation of feeding behavior
0.40	GO:0009593	detection of chemical stimulus
0.39	GO:0018108	peptidyl-tyrosine phosphorylation
0.38	GO:0009755	hormone-mediated signaling pathway
0.36	GO:0008340	determination of adult lifespan
0.36	GO:0007268	chemical synaptic transmission

0.72	GO:0004930	G-protein coupled receptor activity
0.68	GO:0001653	peptide receptor activity
0.42	GO:0042071	leucokinin receptor activity
0.41	GO:0004984	olfactory receptor activity
0.39	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.38	GO:0050254	rhodopsin kinase activity
0.37	GO:0042923	neuropeptide binding

0.39	GO:0016323	basolateral plasma membrane
0.36	GO:0043005	neuron projection
0.35	GO:0005887	integral component of plasma membrane

0.39

GO:0004715

tr|T1EI04|T1EI04_HELRO
Uncharacterized protein
Search

0.70	GO:0007219	Notch signaling pathway
0.61	GO:0030154	cell differentiation
0.61	GO:0007275	multicellular organism development
0.59	GO:0050793	regulation of developmental process
0.46	GO:0045967	negative regulation of growth rate
0.44	GO:0046849	bone remodeling
0.44	GO:0046579	positive regulation of Ras protein signal transduction
0.43	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.43	GO:0007050	cell cycle arrest
0.43	GO:0009653	anatomical structure morphogenesis

0.69	GO:0005509	calcium ion binding
0.46	GO:0004872	receptor activity
0.40	GO:0008270	zinc ion binding
0.36	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.35	GO:0004713	protein tyrosine kinase activity
0.34	GO:0004871	signal transducer activity
0.32	GO:0016787	hydrolase activity

0.42	GO:0043235	receptor complex
0.41	GO:0009986	cell surface
0.41	GO:0005654	nucleoplasm
0.39	GO:0005887	integral component of plasma membrane

0.36

EC:1.3.1.74

GO:0032440

tr|T1EI05|T1EI05_HELRO
Uncharacterized protein
Search

0.49	GO:0045087	innate immune response
0.46	GO:0002755	MyD88-dependent toll-like receptor signaling pathway
0.46	GO:0050707	regulation of cytokine secretion
0.46	GO:0034134	toll-like receptor 2 signaling pathway
0.45	GO:0002237	response to molecule of bacterial origin
0.44	GO:0050729	positive regulation of inflammatory response
0.44	GO:0006954	inflammatory response
0.43	GO:0006468	protein phosphorylation
0.36	GO:0098542	defense response to other organism
0.36	GO:0034142	toll-like receptor 4 signaling pathway

0.43	GO:0016301	kinase activity
0.42	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.41	GO:0140096	catalytic activity, acting on a protein
0.40	GO:0030554	adenyl nucleotide binding
0.40	GO:0097367	carbohydrate derivative binding
0.39	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0008144	drug binding
0.36	GO:0001875	lipopolysaccharide receptor activity
0.36	GO:0005520	insulin-like growth factor binding
0.35	GO:0032440	2-alkenal reductase [NAD(P)] activity

0.36	GO:0042567	insulin-like growth factor ternary complex
0.36	GO:0046696	lipopolysaccharide receptor complex
0.36	GO:0044459	plasma membrane part
0.35	GO:0055044	symplast
0.35	GO:0005578	proteinaceous extracellular matrix
0.34	GO:0005911	cell-cell junction
0.34	GO:0005654	nucleoplasm
0.34	GO:0009986	cell surface
0.34	GO:0098552	side of membrane
0.34	GO:0005618	cell wall

0.42

GO:0016773

tr|T1EI06|T1EI06_HELRO
Uncharacterized protein
Search

0.39	GO:1903506	regulation of nucleic acid-templated transcription
0.39	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.39	GO:0010468	regulation of gene expression
0.38	GO:0051254	positive regulation of RNA metabolic process
0.37	GO:0010557	positive regulation of macromolecule biosynthetic process
0.37	GO:0031328	positive regulation of cellular biosynthetic process
0.37	GO:1902679	negative regulation of RNA biosynthetic process
0.37	GO:1900436	positive regulation of filamentous growth of a population of unicellular organisms in response to starvation
0.36	GO:0006366	transcription by RNA polymerase II
0.36	GO:0031670	cellular response to nutrient

0.51	GO:0003676	nucleic acid binding
0.39	GO:0046872	metal ion binding
0.39	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.37	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.35	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.33	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.33	GO:0005515	protein binding
0.33	GO:0008168	methyltransferase activity

0.40	GO:0005634	nucleus
0.37	GO:0045111	intermediate filament cytoskeleton
0.35	GO:0005829	cytosol
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part
0.33	GO:0005739	mitochondrion
0.33	GO:0032126	eisosome

0.33

EC:5.2.1.8

GO:0003755

tr|T1EI07|T1EI07_HELRO
Uncharacterized protein
Search

0.46	Tyrosine-protein kinase CSK

0.77

GO:0018108

peptidyl-tyrosine phosphorylation

0.77	GO:0004713	protein tyrosine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.77

GO:0004713

tr|T1EI08|T1EI08_HELRO
Uncharacterized protein
Search

0.34	Cold-shock DNA-binding domain protein (Fragment)

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.34	GO:0048599	oocyte development
0.34	GO:0051260	protein homooligomerization
0.33	GO:0007018	microtubule-based movement
0.33	GO:0018108	peptidyl-tyrosine phosphorylation
0.33	GO:0006351	transcription, DNA-templated

0.55	GO:0003677	DNA binding
0.34	GO:0005509	calcium ion binding
0.33	GO:0003777	microtubule motor activity
0.33	GO:0008017	microtubule binding
0.33	GO:0003779	actin binding
0.33	GO:0004713	protein tyrosine kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003723	RNA binding

0.42	GO:0001650	fibrillar center
0.33	GO:0016459	myosin complex
0.33	GO:0005783	endoplasmic reticulum
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0004713

tr|T1EI09|T1EI09_HELRO
Uncharacterized protein
Search

tr|T1EI10|T1EI10_HELRO
Uncharacterized protein
Search

ENTPD6

0.63	Ectonucleoside triphosphate diphosphohydrolase 5

0.42	GO:0030282	bone mineralization
0.40	GO:0055062	phosphate ion homeostasis
0.37	GO:0032026	response to magnesium ion
0.36	GO:0051592	response to calcium ion

0.51

GO:0016787

hydrolase activity

0.42	GO:0005794	Golgi apparatus
0.35	GO:0009986	cell surface
0.35	GO:0005615	extracellular space
0.34	GO:1903561	extracellular vesicle
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0031984	organelle subcompartment
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.51

GO:0016787

tr|T1EI11|T1EI11_HELRO
Uncharacterized protein
Search

0.42	Tyrosine-protein kinase receptor

0.76	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.75	GO:0018108	peptidyl-tyrosine phosphorylation
0.60	GO:0071469	cellular response to alkaline pH
0.56	GO:0046777	protein autophosphorylation
0.44	GO:0030238	male sex determination
0.42	GO:0060267	positive regulation of respiratory burst
0.42	GO:0045821	positive regulation of glycolytic process
0.42	GO:2000194	regulation of female gonad development
0.42	GO:0045725	positive regulation of glycogen biosynthetic process
0.41	GO:0031017	exocrine pancreas development

0.78	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.60	GO:0043560	insulin receptor substrate binding
0.59	GO:0043548	phosphatidylinositol 3-kinase binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0051425	PTB domain binding
0.42	GO:0043559	insulin binding
0.42	GO:0031995	insulin-like growth factor II binding

0.50	GO:0005887	integral component of plasma membrane
0.43	GO:0043235	receptor complex
0.42	GO:0106003	amyloid-beta complex
0.40	GO:0005901	caveola
0.40	GO:1902911	protein kinase complex
0.39	GO:0005635	nuclear envelope
0.37	GO:0031981	nuclear lumen
0.35	GO:0032809	neuronal cell body membrane
0.35	GO:0032590	dendrite membrane
0.34	GO:0009897	external side of plasma membrane

0.78

EC:2.7.10.1

GO:0004714

tr|T1EI12|T1EI12_HELRO
Uncharacterized protein
Search

0.11

Tensin

0.61	GO:0035556	intracellular signal transduction
0.46	GO:0035335	peptidyl-tyrosine dephosphorylation
0.42	GO:0010761	fibroblast migration
0.42	GO:0007044	cell-substrate junction assembly
0.39	GO:0008104	protein localization

0.49	GO:0046872	metal ion binding
0.46	GO:0004725	protein tyrosine phosphatase activity

0.48	GO:0005925	focal adhesion
0.44	GO:0005622	intracellular
0.30	GO:0044425	membrane part

0.46

GO:0004725

tr|T1EI13|T1EI13_HELRO
Uncharacterized protein
Search

UTP23

0.84	rRNA-processing protein UTP23 homolog (inferred by orthology to a human protein)

0.49	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.46	GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.39	GO:0009793	embryo development ending in seed dormancy
0.34	GO:0007031	peroxisome organization
0.33	GO:0098655	cation transmembrane transport
0.33	GO:0034654	nucleobase-containing compound biosynthetic process
0.33	GO:0006260	DNA replication
0.32	GO:0006281	DNA repair

0.46	GO:0003730	mRNA 3'-UTR binding
0.46	GO:0070181	small ribosomal subunit rRNA binding
0.46	GO:0048027	mRNA 5'-UTR binding
0.33	GO:0008324	cation transmembrane transporter activity
0.33	GO:0005515	protein binding
0.33	GO:0008408	3'-5' exonuclease activity
0.33	GO:0003887	DNA-directed DNA polymerase activity
0.32	GO:0008270	zinc ion binding
0.32	GO:0003677	DNA binding
0.32	GO:1901265	nucleoside phosphate binding

0.79	GO:0032040	small-subunit processome
0.44	GO:0005730	nucleolus
0.34	GO:0005779	integral component of peroxisomal membrane
0.34	GO:0008622	epsilon DNA polymerase complex

0.33

GO:0003887

tr|T1EI14|T1EI14_HELRO
Uncharacterized protein
Search

0.10	membrane progestin receptor beta-like

0.49	GO:0043401	steroid hormone mediated signaling pathway
0.39	GO:0048477	oogenesis
0.38	GO:0072383	plus-end-directed vesicle transport along microtubule
0.38	GO:0044837	actomyosin contractile ring organization
0.38	GO:0000912	assembly of actomyosin apparatus involved in cytokinesis
0.37	GO:0007275	multicellular organism development

0.51	GO:0005496	steroid binding
0.50	GO:0003707	steroid hormone receptor activity
0.36	GO:0003777	microtubule motor activity
0.36	GO:0008017	microtubule binding
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.40	GO:0005886	plasma membrane
0.32	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

tr|T1EI15|T1EI15_HELRO
Uncharacterized protein
Search

0.42	Tyrosine-protein kinase receptor (Fragment)

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.73	GO:0006182	cGMP biosynthetic process
0.53	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.47	GO:0071469	cellular response to alkaline pH
0.45	GO:0007186	G-protein coupled receptor signaling pathway
0.43	GO:0007285	primary spermatocyte growth
0.43	GO:0042321	negative regulation of circadian sleep/wake cycle, sleep
0.43	GO:0007446	imaginal disc growth
0.43	GO:0060250	germ-line stem-cell niche homeostasis
0.43	GO:2000252	negative regulation of feeding behavior

0.77	GO:0004713	protein tyrosine kinase activity
0.73	GO:0004383	guanylate cyclase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.54	GO:0019199	transmembrane receptor protein kinase activity
0.50	GO:0004965	G-protein coupled GABA receptor activity
0.41	GO:0016500	protein-hormone receptor activity
0.39	GO:0042802	identical protein binding

0.43	GO:0005899	insulin receptor complex
0.39	GO:0005911	cell-cell junction
0.35	GO:0098533	ATPase dependent transmembrane transport complex
0.35	GO:0098797	plasma membrane protein complex
0.35	GO:0038039	G-protein coupled receptor heterodimeric complex
0.35	GO:0061177	type Is terminal bouton
0.35	GO:0061176	type Ib terminal bouton
0.35	GO:0071212	subsynaptic reticulum

0.77

GO:0004713

tr|T1EI16|T1EI16_HELRO
Uncharacterized protein
Search

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.43	GO:0007631	feeding behavior
0.42	GO:0008015	blood circulation
0.41	GO:1901652	response to peptide
0.40	GO:0007268	chemical synaptic transmission
0.40	GO:0032870	cellular response to hormone stimulus
0.40	GO:0035296	regulation of tube diameter
0.39	GO:0003018	vascular process in circulatory system
0.39	GO:0044057	regulation of system process
0.38	GO:0071417	cellular response to organonitrogen compound

0.75	GO:0008188	neuropeptide receptor activity
0.40	GO:0004945	angiotensin type II receptor activity
0.40	GO:0016499	orexin receptor activity
0.38	GO:0042277	peptide binding
0.38	GO:0004875	complement receptor activity
0.36	GO:0004974	leukotriene receptor activity
0.36	GO:0001847	opsonin receptor activity
0.35	GO:0004962	endothelin receptor activity

0.41	GO:0005886	plasma membrane
0.36	GO:0061827	sperm head
0.36	GO:0120025	plasma membrane bounded cell projection
0.35	GO:0097458	neuron part
0.34	GO:0044463	cell projection part
0.33	GO:0044422	organelle part
0.30	GO:0031224	intrinsic component of membrane

tr|T1EI17|T1EI17_HELRO
Uncharacterized protein
Search

0.56	hepatocyte growth factor receptor-like

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.62	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.58	GO:2001028	positive regulation of endothelial cell chemotaxis
0.56	GO:0050918	positive chemotaxis
0.55	GO:0071526	semaphorin-plexin signaling pathway
0.52	GO:0070495	negative regulation of thrombin-activated receptor signaling pathway
0.52	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity
0.51	GO:0050878	regulation of body fluid levels
0.51	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
0.51	GO:0001886	endothelial cell morphogenesis

0.77	GO:0004713	protein tyrosine kinase activity
0.66	GO:0019199	transmembrane receptor protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0019903	protein phosphatase binding
0.47	GO:0043548	phosphatidylinositol 3-kinase binding
0.45	GO:0042802	identical protein binding
0.41	GO:0046982	protein heterodimerization activity

0.50	GO:0009925	basal plasma membrane
0.39	GO:0005635	nuclear envelope
0.38	GO:0005789	endoplasmic reticulum membrane
0.35	GO:0098794	postsynapse
0.35	GO:0005887	integral component of plasma membrane
0.35	GO:0009986	cell surface
0.34	GO:0060076	excitatory synapse
0.34	GO:0036126	sperm flagellum
0.34	GO:0032279	asymmetric synapse
0.34	GO:0005576	extracellular region

0.77	EC:2.7.10	GO:0004713
0.35	KEGG:R04545	GO:0046934

tr|T1EI18|T1EI18_HELRO
Uncharacterized protein
Search

0.84	Xylosylprotein 4-beta-galactosyltransferase

0.60	GO:0005975	carbohydrate metabolic process
0.49	GO:0006029	proteoglycan metabolic process
0.45	GO:0006491	N-glycan processing
0.45	GO:0009101	glycoprotein biosynthetic process
0.42	GO:0048147	negative regulation of fibroblast proliferation
0.40	GO:0006024	glycosaminoglycan biosynthetic process
0.39	GO:0097435	supramolecular fiber organization
0.38	GO:0043413	macromolecule glycosylation
0.38	GO:1903510	mucopolysaccharide metabolic process
0.36	GO:0036211	protein modification process

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.49	GO:0140103	catalytic activity, acting on a glycoprotein
0.38	GO:0030145	manganese ion binding
0.34	GO:1901265	nucleoside phosphate binding
0.34	GO:0097367	carbohydrate derivative binding
0.34	GO:0036402	proteasome-activating ATPase activity
0.34	GO:0036094	small molecule binding
0.34	GO:0043168	anion binding
0.33	GO:0008144	drug binding
0.33	GO:0005515	protein binding

0.44	GO:0005794	Golgi apparatus
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0031984	organelle subcompartment
0.30	GO:0031224	intrinsic component of membrane

0.65

GO:0016757

tr|T1EI19|T1EI19_HELRO
Uncharacterized protein
Search

0.68	Hepatocyte growth factor receptor (Fragment)

0.71	GO:0018108	peptidyl-tyrosine phosphorylation
0.69	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.64	GO:2001028	positive regulation of endothelial cell chemotaxis
0.61	GO:0050918	positive chemotaxis
0.59	GO:0071526	semaphorin-plexin signaling pathway
0.51	GO:0070495	negative regulation of thrombin-activated receptor signaling pathway
0.51	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity
0.51	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
0.50	GO:0001886	endothelial cell morphogenesis
0.50	GO:0051497	negative regulation of stress fiber assembly

0.71	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.52	GO:0030554	adenyl nucleotide binding
0.51	GO:0097367	carbohydrate derivative binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0019903	protein phosphatase binding
0.45	GO:0042802	identical protein binding
0.36	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.35	GO:0043274	phospholipase binding
0.35	GO:0043548	phosphatidylinositol 3-kinase binding

0.49	GO:0009925	basal plasma membrane
0.36	GO:0098794	postsynapse
0.36	GO:0009986	cell surface
0.35	GO:0060076	excitatory synapse
0.35	GO:0036126	sperm flagellum
0.35	GO:0032279	asymmetric synapse
0.35	GO:0005576	extracellular region
0.35	GO:0043025	neuronal cell body
0.35	GO:0030425	dendrite
0.34	GO:0097060	synaptic membrane

0.71	EC:2.7.10.1	GO:0004714
0.36	KEGG:R04545	GO:0046934

tr|T1EI20|T1EI20_HELRO
Uncharacterized protein
Search

0.76	Glutamate receptor 1-like

0.75	GO:0060079	excitatory postsynaptic potential
0.73	GO:0035235	ionotropic glutamate receptor signaling pathway
0.57	GO:0034220	ion transmembrane transport
0.36	GO:0060992	response to fungicide
0.36	GO:0010226	response to lithium ion
0.35	GO:0035249	synaptic transmission, glutamatergic
0.35	GO:0001919	regulation of receptor recycling

0.77	GO:0005234	extracellularly glutamate-gated ion channel activity
0.73	GO:0004970	ionotropic glutamate receptor activity
0.38	GO:0099094	ligand-gated cation channel activity
0.37	GO:0001540	amyloid-beta binding
0.35	GO:0030165	PDZ domain binding

0.74	GO:0045211	postsynaptic membrane
0.70	GO:0030054	cell junction
0.39	GO:0032281	AMPA glutamate receptor complex
0.37	GO:0043197	dendritic spine
0.36	GO:0098843	postsynaptic endocytic zone
0.36	GO:0106003	amyloid-beta complex
0.35	GO:0043083	synaptic cleft
0.35	GO:0060076	excitatory synapse
0.35	GO:0043198	dendritic shaft
0.35	GO:0043204	perikaryon

tr|T1EI21|T1EI21_HELRO
Uncharacterized protein
Search

0.10	Putative tyrosine kinase receptor (Fragment)

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.68	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.58	GO:0048484	enteric nervous system development
0.57	GO:0001755	neural crest cell migration
0.57	GO:0061146	Peyer's patch morphogenesis
0.56	GO:0035799	ureter maturation
0.56	GO:0072300	positive regulation of metanephric glomerulus development
0.55	GO:0071300	cellular response to retinoic acid
0.55	GO:0007158	neuron cell-cell adhesion
0.55	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein

0.77	GO:0004713	protein tyrosine kinase activity
0.64	GO:0019199	transmembrane receptor protein kinase activity
0.63	GO:0005509	calcium ion binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0005515	protein binding
0.40	GO:0003777	microtubule motor activity
0.36	GO:0008376	acetylgalactosaminyltransferase activity

0.64	GO:0098857	membrane microdomain
0.50	GO:0043235	receptor complex
0.50	GO:0010008	endosome membrane
0.48	GO:0005886	plasma membrane
0.47	GO:0005829	cytosol
0.43	GO:0098796	membrane protein complex
0.42	GO:0043231	intracellular membrane-bounded organelle
0.39	GO:0120025	plasma membrane bounded cell projection
0.38	GO:0031252	cell leading edge
0.37	GO:0043025	neuronal cell body

0.77

GO:0004713

tr|T1EI22|T1EI22_HELRO
Uncharacterized protein
Search

VASH2

0.62	Vasohibin 2

0.82	GO:0045765	regulation of angiogenesis
0.62	GO:0001937	negative regulation of endothelial cell proliferation
0.60	GO:2000181	negative regulation of blood vessel morphogenesis

0.49	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

tr|T1EI23|T1EI23_HELRO
Uncharacterized protein
Search

tr|T1EI24|T1EI24_HELRO
Uncharacterized protein
Search

0.42	GO:0006468	protein phosphorylation
0.41	GO:0007165	signal transduction
0.39	GO:0048813	dendrite morphogenesis
0.39	GO:0001701	in utero embryonic development
0.38	GO:0050728	negative regulation of inflammatory response
0.38	GO:1901222	regulation of NIK/NF-kappaB signaling
0.38	GO:0061399	positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion
0.38	GO:0009116	nucleoside metabolic process
0.38	GO:0036083	positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
0.37	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

0.43	GO:0004672	protein kinase activity
0.40	GO:0031867	EP4 subtype prostaglandin E2 receptor binding
0.39	GO:0030554	adenyl nucleotide binding
0.39	GO:0046872	metal ion binding
0.39	GO:0097367	carbohydrate derivative binding
0.39	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0008144	drug binding
0.36	GO:0005216	ion channel activity
0.36	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
0.35	GO:0022835	transmitter-gated channel activity

0.36	GO:0045170	spectrosome
0.36	GO:0045211	postsynaptic membrane
0.35	GO:0030176	integral component of endoplasmic reticulum membrane
0.35	GO:0030054	cell junction
0.35	GO:0005634	nucleus
0.34	GO:0005815	microtubule organizing center
0.34	GO:1905369	endopeptidase complex
0.34	GO:0005615	extracellular space
0.33	GO:0005694	chromosome
0.33	GO:0005829	cytosol

0.35	EC:2.4.2.30	GO:0003950
0.33	KEGG:R03876	GO:0004842

tr|T1EI25|T1EI25_HELRO
Uncharacterized protein
Search

0.61	GO:0006278	RNA-dependent DNA biosynthetic process
0.56	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.53	GO:0101030	tRNA-guanine transglycosylation

0.61	GO:0003964	RNA-directed DNA polymerase activity
0.58	GO:0004519	endonuclease activity
0.53	GO:0008479	queuine tRNA-ribosyltransferase activity
0.47	GO:0046983	protein dimerization activity
0.41	GO:0046872	metal ion binding

0.39	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.61

GO:0003964

tr|T1EI26|T1EI26_HELRO
Uncharacterized protein
Search

0.56	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

0.50	GO:0019878	lysine biosynthetic process via aminoadipic acid
0.49	GO:0006633	fatty acid biosynthetic process

0.78	GO:0008897	holo-[acyl-carrier-protein] synthase activity
0.64	GO:0000287	magnesium ion binding

0.78

EC:2.7.8.7

GO:0008897

tr|T1EI27|T1EI27_HELRO
Uncharacterized protein
Search

0.71	Phosphatidate phosphatase LPIN3 (Fragment)

0.72	GO:0007474	imaginal disc-derived wing vein specification
0.71	GO:0019432	triglyceride biosynthetic process
0.70	GO:0030514	negative regulation of BMP signaling pathway
0.68	GO:0019217	regulation of fatty acid metabolic process
0.68	GO:0055088	lipid homeostasis
0.64	GO:0042594	response to starvation
0.53	GO:0016311	dephosphorylation
0.47	GO:0009062	fatty acid catabolic process
0.47	GO:0045944	positive regulation of transcription by RNA polymerase II
0.45	GO:0007078	lamin depolymerization

0.63	GO:0008195	phosphatidate phosphatase activity
0.59	GO:0003713	transcription coactivator activity

0.77	GO:0035183	female germline ring canal inner rim
0.55	GO:0005634	nucleus
0.44	GO:0005737	cytoplasm
0.38	GO:0012505	endomembrane system
0.38	GO:0043233	organelle lumen
0.37	GO:0031967	organelle envelope
0.30	GO:0016021	integral component of membrane

0.63

EC:3.1.3.4

GO:0008195

tr|T1EI28|T1EI28_HELRO
Uncharacterized protein
Search

0.56	GO:0060255	regulation of macromolecule metabolic process
0.52	GO:0007143	female meiotic nuclear division
0.50	GO:0048477	oogenesis
0.50	GO:0010923	negative regulation of phosphatase activity
0.47	GO:0006302	double-strand break repair

0.56	GO:0003723	RNA binding
0.33	GO:0046872	metal ion binding

0.76	GO:0005777	peroxisome
0.45	GO:0005794	Golgi apparatus
0.34	GO:0005578	proteinaceous extracellular matrix
0.30	GO:0016020	membrane

tr|T1EI29|T1EI29_HELRO
Uncharacterized protein
Search

tr|T1EI30|T1EI30_HELRO
Uncharacterized protein
Search

0.57	Transmembrane protein 164

0.30

GO:0044425

membrane part

tr|T1EI31|T1EI31_HELRO
Uncharacterized protein
Search

0.10	Receptor-type tyrosine-protein phosphatase N2 (Fragment)

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.44	GO:0048513	animal organ development
0.43	GO:0045859	regulation of protein kinase activity
0.43	GO:0033277	abortive mitotic cell cycle
0.42	GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin
0.42	GO:0050859	negative regulation of B cell receptor signaling pathway
0.42	GO:0050860	negative regulation of T cell receptor signaling pathway
0.42	GO:0042267	natural killer cell mediated cytotoxicity
0.42	GO:0036344	platelet morphogenesis
0.42	GO:0033630	positive regulation of cell adhesion mediated by integrin

0.75	GO:0004725	protein tyrosine phosphatase activity
0.45	GO:0019198	transmembrane receptor protein phosphatase activity
0.43	GO:0140031	phosphorylation-dependent protein binding
0.41	GO:0042169	SH2 domain binding
0.41	GO:0001784	phosphotyrosine residue binding
0.40	GO:0050839	cell adhesion molecule binding
0.40	GO:0019901	protein kinase binding
0.40	GO:0017124	SH3 domain binding
0.39	GO:0035374	chondroitin sulfate binding
0.38	GO:0008201	heparin binding

0.42	GO:0042105	alpha-beta T cell receptor complex
0.39	GO:0005911	cell-cell junction
0.39	GO:0005730	nucleolus
0.37	GO:0005737	cytoplasm
0.36	GO:0043234	protein complex
0.33	GO:0005576	extracellular region
0.33	GO:0031982	vesicle
0.30	GO:0016021	integral component of membrane

0.75

GO:0004725

tr|T1EI32|T1EI32_HELRO
Uncharacterized protein
Search

0.56	Microfibril-associated glycoprotein 4

0.68	GO:0007596	blood coagulation
0.60	GO:0001775	cell activation
0.59	GO:0051258	protein polymerization
0.56	GO:0042127	regulation of cell proliferation
0.54	GO:0007155	cell adhesion
0.50	GO:0023052	signaling
0.50	GO:0007154	cell communication
0.48	GO:0051716	cellular response to stimulus
0.42	GO:0060740	prostate gland epithelium morphogenesis
0.42	GO:0048678	response to axon injury

0.61	GO:0030674	protein binding, bridging
0.56	GO:0005102	receptor binding
0.43	GO:0045545	syndecan binding
0.38	GO:0004857	enzyme inhibitor activity
0.36	GO:0050839	cell adhesion molecule binding
0.36	GO:0042802	identical protein binding
0.36	GO:0030545	receptor regulator activity
0.35	GO:0032403	protein complex binding
0.33	GO:0046872	metal ion binding

0.65	GO:0005577	fibrinogen complex
0.55	GO:0031012	extracellular matrix
0.36	GO:0005769	early endosome
0.36	GO:0009986	cell surface
0.35	GO:0005794	Golgi apparatus

tr|T1EI33|T1EI33_HELRO
Uncharacterized protein
Search

0.60	GO:0036211	protein modification process
0.56	GO:0044267	cellular protein metabolic process
0.45	GO:0060271	cilium assembly
0.34	GO:0001578	microtubule bundle formation
0.32	GO:0006259	DNA metabolic process

0.57	GO:0070735	protein-glycine ligase activity
0.39	GO:0032559	adenyl ribonucleotide binding
0.39	GO:0008144	drug binding
0.39	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0004835	tubulin-tyrosine ligase activity
0.33	GO:0008854	exodeoxyribonuclease V activity
0.32	GO:0046872	metal ion binding

0.46	GO:0015630	microtubule cytoskeleton
0.46	GO:0005930	axoneme
0.36	GO:0099513	polymeric cytoskeletal fiber
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.57

EC:6.3.2

GO:0070735

tr|T1EI34|T1EI34_HELRO
Uncharacterized protein
Search

tr|T1EI35|T1EI35_HELRO
Uncharacterized protein
Search

0.69	Radial spoke head protein 4 A (Fragment)

0.67	GO:0035082	axoneme assembly
0.66	GO:0003341	cilium movement

0.36

GO:0046872

metal ion binding

0.65	GO:0005930	axoneme
0.59	GO:0005730	nucleolus
0.56	GO:0005654	nucleoplasm
0.38	GO:0031514	motile cilium
0.36	GO:0043234	protein complex

tr|T1EI36|T1EI36_HELRO
Uncharacterized protein
Search

0.60	Translation initiation factor 4F ribosome/mRNA-bridging subunit (Fragment)

0.71	GO:0006413	translational initiation
0.36	GO:0060903	positive regulation of meiosis I
0.35	GO:0007283	spermatogenesis
0.35	GO:0045727	positive regulation of translation
0.35	GO:0001934	positive regulation of protein phosphorylation
0.33	GO:0010507	negative regulation of autophagy
0.32	GO:0006508	proteolysis

0.72	GO:0003743	translation initiation factor activity
0.66	GO:0000339	RNA cap binding
0.62	GO:0003729	mRNA binding
0.33	GO:0004222	metalloendopeptidase activity
0.33	GO:0005515	protein binding

0.30

GO:0031224

intrinsic component of membrane

0.33

GO:0004222

tr|T1EI37|T1EI37_HELRO
One cut domain family member
Search

0.49	One cut domain family member

0.56	GO:0006351	transcription, DNA-templated
0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.51	GO:0048536	spleen development
0.50	GO:0031018	endocrine pancreas development
0.50	GO:0030183	B cell differentiation
0.50	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.50	GO:0007492	endoderm development
0.50	GO:0001889	liver development

0.53	GO:0003677	DNA binding
0.51	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.44	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding

0.59	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

tr|T1EI38|T1EI38_HELRO
Uncharacterized protein
Search

0.63	GO:0006468	protein phosphorylation
0.61	GO:0018212	peptidyl-tyrosine modification
0.52	GO:0060071	Wnt signaling pathway, planar cell polarity pathway
0.52	GO:0060026	convergent extension
0.51	GO:0001736	establishment of planar polarity
0.47	GO:0009558	embryo sac cellularization
0.46	GO:0007112	male meiosis cytokinesis
0.46	GO:0000911	cytokinesis by cell plate formation
0.43	GO:0090660	cerebrospinal fluid circulation
0.42	GO:2000040	regulation of planar cell polarity pathway involved in axis elongation

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:1904929	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
0.45	GO:0019894	kinesin binding
0.35	GO:0005102	receptor binding
0.35	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.35	GO:0008270	zinc ion binding

0.46	GO:0009524	phragmoplast
0.44	GO:0005887	integral component of plasma membrane
0.38	GO:0070985	TFIIK complex
0.36	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane

0.35

GO:0004553

tr|T1EI39|T1EI39_HELRO
Uncharacterized protein
Search

tr|T1EI40|T1EI40_HELRO
Hexosyltransferase
Search

0.44	Hexosyltransferase

0.74

GO:0006486

protein glycosylation

0.81

GO:0008378

galactosyltransferase activity

0.74	GO:0000139	Golgi membrane
0.30	GO:0031224	intrinsic component of membrane

0.81

GO:0008378

tr|T1EI41|T1EI41_HELRO
Uncharacterized protein
Search

0.53	T-box transcription factor TBX20

0.58	GO:0035050	embryonic heart tube development
0.58	GO:0006351	transcription, DNA-templated
0.58	GO:0060577	pulmonary vein morphogenesis
0.58	GO:0035922	foramen ovale closure
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:0003180	aortic valve morphogenesis
0.56	GO:0003193	pulmonary valve formation
0.56	GO:0010468	regulation of gene expression
0.56	GO:0021524	visceral motor neuron differentiation

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.54	GO:0001105	RNA polymerase II transcription coactivator activity
0.53	GO:0001102	RNA polymerase II activating transcription factor binding
0.50	GO:0001067	regulatory region nucleic acid binding

0.61	GO:0005634	nucleus
0.38	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EI42|T1EI42_HELRO
Uncharacterized protein
Search

0.77	GO:0006171	cAMP biosynthetic process
0.63	GO:0035556	intracellular signal transduction
0.50	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
0.46	GO:0006182	cGMP biosynthetic process
0.39	GO:1904321	response to forskolin
0.39	GO:0008355	olfactory learning
0.38	GO:0007340	acrosome reaction
0.38	GO:0030317	flagellated sperm motility
0.38	GO:1901655	cellular response to ketone
0.37	GO:0035690	cellular response to drug

0.78	GO:0004016	adenylate cyclase activity
0.52	GO:1901265	nucleoside phosphate binding
0.51	GO:0005080	protein kinase C binding
0.50	GO:0036094	small molecule binding
0.49	GO:0097367	carbohydrate derivative binding
0.49	GO:0008144	drug binding
0.48	GO:0043168	anion binding
0.46	GO:0004383	guanylate cyclase activity
0.35	GO:0004672	protein kinase activity
0.34	GO:0031683	G-protein beta/gamma-subunit complex binding

0.54	GO:0005886	plasma membrane
0.48	GO:0030425	dendrite
0.46	GO:0008074	guanylate cyclase complex, soluble
0.37	GO:0005929	cilium
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.78

EC:4.6.1.1

GO:0004016

tr|T1EI43|T1EI43_HELRO
Chloride channel protein
Search

0.29	Chloride channel protein (Fragment)

0.76	GO:1902476	chloride transmembrane transport
0.38	GO:0050975	sensory perception of touch
0.34	GO:0035235	ionotropic glutamate receptor signaling pathway
0.33	GO:0034765	regulation of ion transmembrane transport

0.77	GO:0005247	voltage-gated chloride channel activity
0.34	GO:0004970	ionotropic glutamate receptor activity

0.41	GO:0005654	nucleoplasm
0.37	GO:0005770	late endosome
0.37	GO:0005764	lysosome
0.34	GO:0034707	chloride channel complex
0.33	GO:0005887	integral component of plasma membrane

tr|T1EI44|T1EI44_HELRO
Uncharacterized protein
Search

0.52	Transcriptional activator Myb (Fragment)

0.51	GO:0090307	mitotic spindle assembly
0.50	GO:1990830	cellular response to leukemia inhibitory factor
0.47	GO:0006357	regulation of transcription by RNA polymerase II
0.47	GO:0006366	transcription by RNA polymerase II
0.47	GO:0045893	positive regulation of transcription, DNA-templated
0.43	GO:0030154	cell differentiation
0.37	GO:0043525	positive regulation of neuron apoptotic process
0.34	GO:0009753	response to jasmonic acid
0.34	GO:0009723	response to ethylene
0.34	GO:0009751	response to salicylic acid

0.55	GO:0003677	DNA binding
0.50	GO:0001067	regulatory region nucleic acid binding
0.49	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.48	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting
0.36	GO:0005515	protein binding
0.33	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0008270	zinc ion binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0016491	oxidoreductase activity
0.32	GO:0032555	purine ribonucleotide binding

0.52	GO:0031523	Myb complex
0.45	GO:0005654	nucleoplasm
0.30	GO:0016021	integral component of membrane

0.33

GO:0004674

tr|T1EI45|T1EI45_HELRO
Uncharacterized protein
Search

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.38	GO:0010942	positive regulation of cell death
0.35	GO:0031581	hemidesmosome assembly
0.34	GO:0007160	cell-matrix adhesion
0.34	GO:0007229	integrin-mediated signaling pathway
0.34	GO:0006419	alanyl-tRNA aminoacylation
0.33	GO:0048870	cell motility
0.33	GO:0015671	oxygen transport

0.34	GO:0004813	alanine-tRNA ligase activity
0.34	GO:0004197	cysteine-type endopeptidase activity
0.33	GO:0003676	nucleic acid binding
0.33	GO:0005344	oxygen carrier activity
0.33	GO:0004872	receptor activity
0.33	GO:0008270	zinc ion binding
0.33	GO:0016301	kinase activity
0.32	GO:0020037	heme binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.38	GO:0045111	intermediate filament cytoskeleton
0.37	GO:0005634	nucleus
0.36	GO:0031974	membrane-enclosed lumen
0.35	GO:0044446	intracellular organelle part
0.34	GO:0008305	integrin complex
0.32	GO:0005737	cytoplasm

0.34

EC:6.1.1.7

GO:0004813

tr|T1EI46|T1EI46_HELRO
Uncharacterized protein
Search

0.30

GO:0044425

membrane part

tr|T1EI47|T1EI47_HELRO
Uncharacterized protein
Search

0.10	Triple functional domain protein isoform x1 (Fragment)

0.78	GO:0035023	regulation of Rho protein signal transduction
0.66	GO:0065009	regulation of molecular function
0.50	GO:0035556	intracellular signal transduction
0.50	GO:0006468	protein phosphorylation
0.40	GO:0043652	engulfment of apoptotic cell
0.40	GO:0048808	male genitalia morphogenesis
0.39	GO:0045773	positive regulation of axon extension
0.39	GO:0035022	positive regulation of Rac protein signal transduction
0.39	GO:0001764	neuron migration
0.39	GO:0008078	mesodermal cell migration

0.78	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.53	GO:0004674	protein serine/threonine kinase activity
0.42	GO:0032559	adenyl ribonucleotide binding
0.41	GO:0008144	drug binding
0.41	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0048365	Rac GTPase binding
0.32	GO:0003676	nucleic acid binding

0.40	GO:0036194	muscle cell projection
0.39	GO:0005622	intracellular
0.38	GO:0030424	axon
0.30	GO:0016020	membrane

0.53

GO:0004674

tr|T1EI48|T1EI48_HELRO
Uncharacterized protein
Search

0.10	Eukaryotic translation initiation factor 4 gamma 1

0.70	GO:0006413	translational initiation
0.53	GO:1905537	positive regulation of eukaryotic translation initiation factor 4F complex assembly
0.53	GO:1905610	regulation of mRNA cap binding
0.52	GO:1905618	positive regulation of miRNA mediated inhibition of translation
0.52	GO:1905696	regulation of polysome binding
0.52	GO:1905606	regulation of presynapse assembly
0.52	GO:2000507	positive regulation of energy homeostasis
0.51	GO:1902416	positive regulation of mRNA binding
0.50	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
0.50	GO:0001662	behavioral fear response

0.70	GO:0003743	translation initiation factor activity
0.70	GO:0003729	mRNA binding
0.60	GO:0008190	eukaryotic initiation factor 4E binding
0.48	GO:0045296	cadherin binding
0.48	GO:0000339	RNA cap binding
0.45	GO:0042802	identical protein binding
0.39	GO:0032559	adenyl ribonucleotide binding
0.38	GO:0008144	drug binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0032947	protein complex scaffold activity

0.51	GO:0016281	eukaryotic translation initiation factor 4F complex
0.48	GO:0005844	polysome
0.44	GO:0005829	cytosol
0.41	GO:0005634	nucleus
0.34	GO:0015935	small ribosomal subunit
0.30	GO:0016020	membrane

tr|T1EI49|T1EI49_HELRO
Uncharacterized protein
Search

0.40	Ubiquitin carboxyl-terminal hydrolase 31

0.76	GO:0016579	protein deubiquitination
0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.39	GO:0006644	phospholipid metabolic process
0.32	GO:0055114	oxidation-reduction process

0.77	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.38	GO:0016746	transferase activity, transferring acyl groups
0.34	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.31	GO:0046872	metal ion binding

0.37	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.77

GO:0036459

tr|T1EI50|T1EI50_HELRO
Uncharacterized protein
Search

tr|T1EI51|T1EI51_HELRO
Uncharacterized protein
Search

0.96	Putative transcriptional activator of the jun family

0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:0010468	regulation of gene expression

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding

tr|T1EI52|T1EI52_HELRO
Uncharacterized protein
Search

0.84	metalloendoproteinase 4-MMP

0.61	GO:0006508	proteolysis
0.41	GO:1900056	negative regulation of leaf senescence
0.40	GO:0080186	developmental vegetative growth
0.40	GO:2000028	regulation of photoperiodism, flowering
0.39	GO:0009753	response to jasmonic acid
0.39	GO:0046686	response to cadmium ion
0.39	GO:0009651	response to salt stress
0.37	GO:0007275	multicellular organism development

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding

0.74	GO:0031012	extracellular matrix
0.46	GO:0031225	anchored component of membrane
0.40	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.70

GO:0004222

tr|T1EI53|T1EI53_HELRO
Uncharacterized protein
Search

MMP7

0.47	Matrix metalloproteinase

0.61	GO:0006508	proteolysis
0.36	GO:0032501	multicellular organismal process
0.36	GO:0006954	inflammatory response
0.35	GO:0042756	drinking behavior
0.35	GO:0048856	anatomical structure development
0.34	GO:0030334	regulation of cell migration
0.34	GO:0042221	response to chemical
0.34	GO:0120036	plasma membrane bounded cell projection organization
0.34	GO:0051606	detection of stimulus
0.34	GO:0030154	cell differentiation

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.34	GO:0004984	olfactory receptor activity
0.33	GO:0004930	G-protein coupled receptor activity
0.33	GO:0030246	carbohydrate binding

0.74	GO:0031012	extracellular matrix
0.34	GO:0031225	anchored component of membrane
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.70

GO:0004222

tr|T1EI54|T1EI54_HELRO
Uncharacterized protein
Search

0.69	Zinc finger MYM-type protein (Fragment)

0.51	GO:0006697	ecdysone biosynthetic process
0.48	GO:0016233	telomere capping
0.47	GO:0006357	regulation of transcription by RNA polymerase II
0.46	GO:0007010	cytoskeleton organization
0.45	GO:0022604	regulation of cell morphogenesis

0.61	GO:0008270	zinc ion binding
0.45	GO:0003682	chromatin binding
0.42	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.38	GO:0005515	protein binding
0.37	GO:0003677	DNA binding

0.50	GO:0035012	polytene chromosome, telomeric region
0.49	GO:0005705	polytene chromosome interband
0.48	GO:0000791	euchromatin
0.47	GO:0000792	heterochromatin
0.46	GO:0005654	nucleoplasm
0.40	GO:0043234	protein complex
0.35	GO:0005737	cytoplasm

tr|T1EI55|T1EI55_HELRO
Uncharacterized protein
Search

0.69	GO:0006915	apoptotic process
0.61	GO:0006508	proteolysis
0.53	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
0.53	GO:0035234	ectopic germ cell programmed cell death
0.52	GO:0038034	signal transduction in absence of ligand
0.51	GO:0071260	cellular response to mechanical stimulus
0.50	GO:0042981	regulation of apoptotic process
0.48	GO:0043068	positive regulation of programmed cell death
0.47	GO:0009967	positive regulation of signal transduction
0.46	GO:0051604	protein maturation

0.75	GO:0004197	cysteine-type endopeptidase activity
0.48	GO:0019904	protein domain specific binding
0.47	GO:0042802	identical protein binding

0.42	GO:0005634	nucleus
0.37	GO:0005737	cytoplasm

0.75

EC:3.4.22

GO:0004197

tr|T1EI56|T1EI56_HELRO
Uncharacterized protein
Search

0.61	GO:0007165	signal transduction
0.59	GO:0043547	positive regulation of GTPase activity
0.50	GO:0007015	actin filament organization
0.46	GO:2001136	negative regulation of endocytic recycling
0.46	GO:0051497	negative regulation of stress fiber assembly
0.45	GO:0007370	ventral furrow formation
0.45	GO:0045887	positive regulation of synaptic growth at neuromuscular junction
0.45	GO:0007480	imaginal disc-derived leg morphogenesis
0.41	GO:0007018	microtubule-based movement
0.36	GO:0051895	negative regulation of focal adhesion assembly

0.59	GO:0005096	GTPase activator activity
0.43	GO:0017137	Rab GTPase binding
0.41	GO:0003777	microtubule motor activity
0.41	GO:0008017	microtubule binding
0.41	GO:0003779	actin binding
0.41	GO:0046872	metal ion binding
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0048365	Rac GTPase binding

0.43	GO:0055037	recycling endosome
0.43	GO:0005769	early endosome
0.42	GO:0016459	myosin complex

0.33

GO:0016740

tr|T1EI57|T1EI57_HELRO
Uncharacterized protein
Search

0.43	GO:0048172	regulation of short-term neuronal synaptic plasticity
0.43	GO:0008586	imaginal disc-derived wing vein morphogenesis
0.43	GO:0007474	imaginal disc-derived wing vein specification
0.43	GO:0046716	muscle cell cellular homeostasis
0.43	GO:0007274	neuromuscular synaptic transmission
0.43	GO:0046928	regulation of neurotransmitter secretion
0.42	GO:0030010	establishment of cell polarity
0.37	GO:0007517	muscle organ development
0.32	GO:0005975	carbohydrate metabolic process
0.32	GO:0055114	oxidation-reduction process

0.63	GO:0008270	zinc ion binding
0.58	GO:0003779	actin binding
0.43	GO:0050699	WW domain binding
0.38	GO:0008307	structural constituent of muscle
0.32	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

0.42	GO:0016010	dystrophin-associated glycoprotein complex
0.40	GO:0045202	synapse
0.39	GO:0005856	cytoskeleton
0.38	GO:0042383	sarcolemma
0.37	GO:0005938	cell cortex

0.32

EC:1.1.1

GO:0016616

tr|T1EI58|T1EI58_HELRO
Uncharacterized protein
Search

0.55	Zinc finger protein 362

0.46	GO:0048699	generation of neurons
0.45	GO:0045925	positive regulation of female receptivity
0.44	GO:0051961	negative regulation of nervous system development
0.44	GO:0010721	negative regulation of cell development
0.44	GO:0016319	mushroom body development
0.43	GO:0043065	positive regulation of apoptotic process
0.43	GO:0006357	regulation of transcription by RNA polymerase II
0.43	GO:0008344	adult locomotory behavior
0.41	GO:0120036	plasma membrane bounded cell projection organization
0.41	GO:0048468	cell development

0.51	GO:0003676	nucleic acid binding
0.44	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.39	GO:0046872	metal ion binding
0.36	GO:0015271	outward rectifier potassium channel activity
0.34	GO:0008134	transcription factor binding
0.33	GO:0005319	lipid transporter activity
0.33	GO:0003682	chromatin binding
0.33	GO:0005044	scavenger receptor activity
0.33	GO:0003777	microtubule motor activity
0.33	GO:0008017	microtubule binding

0.42	GO:0005634	nucleus
0.37	GO:0070013	intracellular organelle lumen
0.36	GO:0043232	intracellular non-membrane-bounded organelle
0.35	GO:0044446	intracellular organelle part
0.35	GO:0017053	transcriptional repressor complex
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

tr|T1EI59|T1EI59_HELRO
Uncharacterized protein
Search

0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:0010468	regulation of gene expression
0.44	GO:0021862	early neuron differentiation in forebrain
0.42	GO:0021952	central nervous system projection neuron axonogenesis
0.41	GO:0021537	telencephalon development

0.65

GO:0043565

sequence-specific DNA binding

0.61

GO:0005634

nucleus

tr|T1EI60|T1EI60_HELRO
Uncharacterized protein
Search

TTLL11

0.91	Tubulin tyrosine ligase like 11

0.60	GO:0036211	protein modification process
0.56	GO:0044267	cellular protein metabolic process
0.50	GO:0051013	microtubule severing
0.32	GO:0055085	transmembrane transport

0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0016874	ligase activity
0.33	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0005509	calcium ion binding

0.35	GO:0005929	cilium
0.35	GO:0005874	microtubule
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.41

GO:0016874

tr|T1EI61|T1EI61_HELRO
Uncharacterized protein
Search

EMC7

0.95	ER membrane protein complex subunit 7

0.34	GO:0030041	actin filament polymerization
0.34	GO:0034314	Arp2/3 complex-mediated actin nucleation
0.34	GO:0071477	cellular hypotonic salinity response
0.33	GO:1902476	chloride transmembrane transport
0.33	GO:0007165	signal transduction

0.63	GO:0030246	carbohydrate binding
0.34	GO:0015379	potassium:chloride symporter activity

0.51	GO:0072546	ER membrane protein complex
0.34	GO:0005885	Arp2/3 protein complex
0.33	GO:0005887	integral component of plasma membrane
0.32	GO:0005840	ribosome

tr|T1EI62|T1EI62_HELRO
Uncharacterized protein
Search

0.46	Remodeling and spacing factor 1

0.64	GO:0016584	nucleosome positioning
0.63	GO:0043392	negative regulation of DNA binding
0.60	GO:0050434	positive regulation of viral transcription
0.59	GO:0006334	nucleosome assembly
0.58	GO:0006338	chromatin remodeling
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:1902680	positive regulation of RNA biosynthetic process
0.55	GO:1902679	negative regulation of RNA biosynthetic process

0.59	GO:0042393	histone binding
0.53	GO:0046872	metal ion binding
0.36	GO:0016887	ATPase activity

0.86	GO:0031213	RSF complex
0.54	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.36

GO:0016887

tr|T1EI63|T1EI63_HELRO
Uncharacterized protein
Search

0.96	Center divider

0.63	GO:0006468	protein phosphorylation
0.41	GO:0035556	intracellular signal transduction
0.40	GO:0018212	peptidyl-tyrosine modification
0.39	GO:0007283	spermatogenesis
0.39	GO:0048041	focal adhesion assembly
0.37	GO:0030036	actin cytoskeleton organization
0.36	GO:0031953	negative regulation of protein autophosphorylation
0.36	GO:0051496	positive regulation of stress fiber assembly
0.35	GO:0071901	negative regulation of protein serine/threonine kinase activity
0.35	GO:0032880	regulation of protein localization

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0046872	metal ion binding
0.41	GO:0004871	signal transducer activity
0.35	GO:0008022	protein C-terminus binding
0.35	GO:0019901	protein kinase binding
0.34	GO:0030942	endoplasmic reticulum signal peptide binding
0.34	GO:0005047	signal recognition particle binding

0.50	GO:0016604	nuclear body
0.36	GO:0005737	cytoplasm
0.34	GO:0097708	intracellular vesicle
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1EI64|T1EI64_HELRO
Uncharacterized protein
Search

0.47	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.47	GO:1903506	regulation of nucleic acid-templated transcription
0.46	GO:0010468	regulation of gene expression
0.36	GO:0097659	nucleic acid-templated transcription
0.35	GO:0010467	gene expression
0.35	GO:0034645	cellular macromolecule biosynthetic process
0.33	GO:0032259	methylation

0.51	GO:0003676	nucleic acid binding
0.46	GO:0046872	metal ion binding
0.40	GO:0003700	DNA binding transcription factor activity
0.33	GO:0005515	protein binding
0.33	GO:0008168	methyltransferase activity

0.41

GO:0005634

nucleus

0.33

GO:0008168

tr|T1EI65|T1EI65_HELRO
Uncharacterized protein
Search

0.10	La ribonucleoprotein domain family, member 1B

0.36	GO:0006396	RNA processing
0.35	GO:0072752	cellular response to rapamycin
0.35	GO:1990928	response to amino acid starvation
0.35	GO:0038202	TORC1 signaling
0.35	GO:0045070	positive regulation of viral genome replication
0.35	GO:0048255	mRNA stabilization
0.35	GO:0016239	positive regulation of macroautophagy
0.34	GO:0008283	cell proliferation
0.34	GO:0045727	positive regulation of translation
0.34	GO:0017148	negative regulation of translation

0.58	GO:0003723	RNA binding
0.35	GO:0008494	translation activator activity
0.35	GO:0008190	eukaryotic initiation factor 4E binding
0.34	GO:0045296	cadherin binding
0.34	GO:0008270	zinc ion binding

0.46	GO:0019013	viral nucleocapsid
0.43	GO:0030529	intracellular ribonucleoprotein complex
0.36	GO:0005634	nucleus
0.34	GO:0031931	TORC1 complex
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.32	GO:0044444	cytoplasmic part
0.30	GO:0016021	integral component of membrane

tr|T1EI66|T1EI66_HELRO
Uncharacterized protein
Search

HDHD2

0.79	Haloacid dehalogenase like hydrolase domain containing 2

0.43	GO:0016311	dephosphorylation
0.33	GO:0006468	protein phosphorylation

0.48	GO:0016787	hydrolase activity
0.45	GO:0019899	enzyme binding
0.35	GO:0046872	metal ion binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.48

GO:0016787

tr|T1EI67|T1EI67_HELRO
Uncharacterized protein
Search

0.58	Endoplasmic Reticulum Oxidoreductin 1

0.53	GO:0055114	oxidation-reduction process
0.41	GO:0034975	protein folding in endoplasmic reticulum
0.36	GO:0036211	protein modification process
0.35	GO:0044267	cellular protein metabolic process
0.35	GO:0030070	insulin processing
0.35	GO:0022417	protein maturation by protein folding
0.35	GO:0019471	4-hydroxyproline metabolic process
0.34	GO:0042593	glucose homeostasis
0.34	GO:0030198	extracellular matrix organization
0.34	GO:0034477	U6 snRNA 3'-end processing

0.83	GO:0003756	protein disulfide isomerase activity
0.76	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
0.38	GO:0015035	protein disulfide oxidoreductase activity
0.34	GO:0016972	thiol oxidase activity
0.34	GO:0070003	threonine-type peptidase activity
0.34	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.33	GO:0004175	endopeptidase activity
0.33	GO:0004518	nuclease activity

0.70	GO:0005783	endoplasmic reticulum
0.38	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.37	GO:0031984	organelle subcompartment
0.34	GO:0019773	proteasome core complex, alpha-subunit complex
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.83

EC:5.3.4.1

GO:0003756

tr|T1EI68|T1EI68_HELRO
Uncharacterized protein
Search

0.83	polycomb group RING finger protein 6-like

0.72	GO:0036353	histone H2A-K119 monoubiquitination
0.59	GO:0045892	negative regulation of transcription, DNA-templated
0.39	GO:0006351	transcription, DNA-templated
0.39	GO:0007568	aging
0.36	GO:0048589	developmental growth
0.35	GO:0006357	regulation of transcription by RNA polymerase II

0.64	GO:0008022	protein C-terminus binding
0.39	GO:0046872	metal ion binding
0.36	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.36	GO:0003677	DNA binding
0.36	GO:0016874	ligase activity
0.35	GO:0001067	regulatory region nucleic acid binding

0.81	GO:0031519	PcG protein complex
0.64	GO:0000152	nuclear ubiquitin ligase complex
0.55	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.36

GO:0016874

tr|T1EI69|T1EI69_HELRO
Uncharacterized protein
Search

HSCB

0.85	HscB mitochondrial iron-sulfur cluster cochaperone

0.81	GO:0032781	positive regulation of ATPase activity
0.78	GO:0097428	protein maturation by iron-sulfur cluster transfer
0.73	GO:0051259	protein oligomerization
0.38	GO:0006508	proteolysis
0.36	GO:0031163	metallo-sulfur cluster assembly
0.35	GO:0006790	sulfur compound metabolic process
0.35	GO:0051188	cofactor biosynthetic process

0.82	GO:0001671	ATPase activator activity
0.77	GO:0051087	chaperone binding
0.41	GO:0004252	serine-type endopeptidase activity
0.36	GO:0042802	identical protein binding

0.39	GO:0005739	mitochondrion
0.36	GO:0005829	cytosol
0.35	GO:0005634	nucleus

0.41

GO:0004252

tr|T1EI70|T1EI70_HELRO
Uncharacterized protein
Search

METTL26

0.30	SAM-dependent methyltransferase

0.63

GO:0032259

methylation

0.63

GO:0008168

methyltransferase activity

0.63

GO:0008168

tr|T1EI71|T1EI71_HELRO
Uncharacterized protein
Search

0.68	Phytanoyl-CoA hydroxylase-interacting protein (Fragment)

0.56

GO:0042450

arginine biosynthetic process via ornithine

0.58	GO:0004056	argininosuccinate lyase activity
0.50	GO:0005515	protein binding
0.49	GO:0008270	zinc ion binding

0.39

GO:0005622

intracellular

0.58

EC:4.3.2.1

GO:0004056

tr|T1EI72|T1EI72_HELRO
Uncharacterized protein
Search

RTFDC1

0.97	Replication termination factor 2 domain containing 1

0.85	GO:1902317	nuclear DNA replication termination
0.83	GO:1902969	mitotic DNA replication
0.50	GO:0071171	site-specific DNA replication termination at RTS1 barrier
0.33	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.33

GO:0004519

endonuclease activity

0.61

GO:0005634

nucleus

tr|T1EI73|T1EI73_HELRO
Uncharacterized protein
Search

0.58	ADP ribosylation factor

0.52	GO:0090383	phagosome acidification
0.52	GO:0090385	phagosome-lysosome fusion
0.37	GO:0032482	Rab protein signal transduction
0.35	GO:0006914	autophagy
0.34	GO:0015031	protein transport
0.33	GO:0006511	ubiquitin-dependent protein catabolic process
0.33	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.33	GO:0006891	intra-Golgi vesicle-mediated transport
0.33	GO:0042147	retrograde transport, endosome to Golgi

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0005515	protein binding
0.33	GO:0005509	calcium ion binding

0.49	GO:0045335	phagocytic vesicle
0.45	GO:0005794	Golgi apparatus
0.42	GO:0043025	neuronal cell body
0.41	GO:0045202	synapse
0.36	GO:0030666	endocytic vesicle membrane
0.35	GO:0005770	late endosome
0.35	GO:0005764	lysosome
0.34	GO:0005829	cytosol
0.33	GO:0005886	plasma membrane
0.33	GO:0005739	mitochondrion

tr|T1EI74|T1EI74_HELRO
Uncharacterized protein
Search

tr|T1EI75|T1EI75_HELRO
Uncharacterized protein
Search

tr|T1EI76|T1EI76_HELRO
Uncharacterized protein
Search

0.70

GO:0005654

nucleoplasm

tr|T1EI77|T1EI77_HELRO
Uncharacterized protein
Search

0.49	Fibrinogen C domain-containing protein 1

0.68	GO:0001525	angiogenesis
0.66	GO:0043066	negative regulation of apoptotic process
0.57	GO:0007596	blood coagulation
0.51	GO:0001775	cell activation
0.51	GO:0051005	negative regulation of lipoprotein lipase activity
0.50	GO:0051258	protein polymerization
0.49	GO:2000351	regulation of endothelial cell apoptotic process
0.49	GO:0070328	triglyceride homeostasis
0.44	GO:0007154	cell communication
0.44	GO:0023052	signaling

0.51	GO:0030674	protein binding, bridging
0.49	GO:0005102	receptor binding
0.46	GO:0004857	enzyme inhibitor activity
0.44	GO:0042802	identical protein binding
0.39	GO:0050839	cell adhesion molecule binding
0.38	GO:0015081	sodium ion transmembrane transporter activity
0.37	GO:0005326	neurotransmitter transporter activity
0.36	GO:0015294	solute:cation symporter activity
0.36	GO:0030545	receptor regulator activity
0.36	GO:0032403	protein complex binding

0.67	GO:0005615	extracellular space
0.43	GO:0043234	protein complex
0.39	GO:0005578	proteinaceous extracellular matrix
0.38	GO:0009986	cell surface
0.38	GO:0031091	platelet alpha granule
0.36	GO:0005769	early endosome
0.36	GO:0005938	cell cortex
0.36	GO:0098552	side of membrane
0.35	GO:0005794	Golgi apparatus
0.35	GO:0044459	plasma membrane part

0.36

GO:0004190

tr|T1EI78|T1EI78_HELRO
Uncharacterized protein
Search

tr|T1EI79|T1EI79_HELRO
Uncharacterized protein
Search

0.62	Nucleic acid binding protein 2

0.67	GO:0070200	establishment of protein localization to telomere
0.65	GO:1904355	positive regulation of telomere capping
0.65	GO:0010212	response to ionizing radiation
0.63	GO:0007093	mitotic cell cycle checkpoint
0.61	GO:0000724	double-strand break repair via homologous recombination
0.39	GO:0030001	metal ion transport
0.36	GO:0055085	transmembrane transport
0.34	GO:0051301	cell division

0.66	GO:0098505	G-rich strand telomeric DNA binding
0.65	GO:0070182	DNA polymerase binding
0.40	GO:0046873	metal ion transmembrane transporter activity
0.37	GO:0003723	RNA binding

0.69	GO:0070876	SOSS complex
0.63	GO:0000784	nuclear chromosome, telomeric region
0.55	GO:0005654	nucleoplasm
0.55	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1EI80|T1EI80_HELRO
Uncharacterized protein
Search

0.52	GO:0016477	cell migration
0.51	GO:0043547	positive regulation of GTPase activity
0.50	GO:0009116	nucleoside metabolic process
0.37	GO:0007165	signal transduction

0.52	GO:0005096	GTPase activator activity
0.39	GO:0046872	metal ion binding
0.37	GO:0003723	RNA binding
0.37	GO:0016740	transferase activity

0.54	GO:0005925	focal adhesion
0.44	GO:1905369	endopeptidase complex
0.43	GO:0005618	cell wall
0.40	GO:0043234	protein complex
0.35	GO:0044424	intracellular part
0.30	GO:0044425	membrane part

0.37

GO:0016740

tr|T1EI81|T1EI81_HELRO
Uncharacterized protein
Search

0.50

Tenascin

0.76	GO:0001525	angiogenesis
0.73	GO:0043066	negative regulation of apoptotic process
0.55	GO:0051005	negative regulation of lipoprotein lipase activity
0.53	GO:0070328	triglyceride homeostasis
0.51	GO:2000351	regulation of endothelial cell apoptotic process
0.45	GO:0007596	blood coagulation
0.43	GO:0019216	regulation of lipid metabolic process
0.42	GO:0007155	cell adhesion
0.41	GO:0001666	response to hypoxia
0.40	GO:0051260	protein homooligomerization

0.49	GO:0004857	enzyme inhibitor activity
0.46	GO:0042802	identical protein binding
0.40	GO:0005509	calcium ion binding
0.38	GO:0005102	receptor binding
0.38	GO:0050839	cell adhesion molecule binding
0.37	GO:0042302	structural constituent of cuticle
0.37	GO:0030545	receptor regulator activity
0.37	GO:0032403	protein complex binding
0.37	GO:0030674	protein binding, bridging
0.35	GO:0003723	RNA binding

0.69	GO:0005615	extracellular space
0.40	GO:0005578	proteinaceous extracellular matrix
0.38	GO:0005769	early endosome
0.37	GO:0009986	cell surface
0.36	GO:0005794	Golgi apparatus
0.34	GO:0043234	protein complex
0.30	GO:0016020	membrane

tr|T1EI82|T1EI82_HELRO
POU domain protein
Search

0.53	Octamer-binding transcription factor 3 alternative variant (Fragment)

0.57	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.46	GO:0001711	endodermal cell fate commitment
0.46	GO:0009786	regulation of asymmetric cell division
0.45	GO:0001712	ectodermal cell fate commitment
0.45	GO:0045955	negative regulation of calcium ion-dependent exocytosis
0.45	GO:0001829	trophectodermal cell differentiation
0.45	GO:0001832	blastocyst growth

0.62	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.48	GO:0035326	enhancer binding
0.48	GO:0019955	cytokine binding
0.45	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding
0.44	GO:0003690	double-stranded DNA binding
0.43	GO:0031490	chromatin DNA binding
0.43	GO:0031625	ubiquitin protein ligase binding
0.43	GO:0003714	transcription corepressor activity
0.42	GO:0001012	RNA polymerase II regulatory region DNA binding

0.61	GO:0005634	nucleus
0.44	GO:0000785	chromatin
0.43	GO:0070013	intracellular organelle lumen
0.43	GO:0017053	transcriptional repressor complex
0.41	GO:0005667	transcription factor complex
0.39	GO:0005829	cytosol
0.36	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

tr|T1EI84|T1EI84_HELRO
Uncharacterized protein
Search

0.10	Methyltransferase domain containing protein

0.38	GO:0032259	methylation
0.34	GO:0016570	histone modification
0.34	GO:0018205	peptidyl-lysine modification
0.34	GO:0008213	protein alkylation
0.33	GO:0071586	CAAX-box protein processing

0.38	GO:0008168	methyltransferase activity
0.34	GO:0047429	nucleoside-triphosphate diphosphatase activity
0.33	GO:0140096	catalytic activity, acting on a protein

0.33	GO:0005634	nucleus
0.32	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.38

GO:0008168

tr|T1EI85|T1EI85_HELRO
Receptor expression-enhancing protein
Search

0.39	Receptor expression-enhancing protein (Fragment)

0.30

GO:0044425

membrane part

tr|T1EI86|T1EI86_HELRO
Uncharacterized protein
Search

0.84	Tubulin polymerization-promoting protein family member 2

0.63	GO:0001578	microtubule bundle formation
0.61	GO:0046785	microtubule polymerization

0.61	GO:0015631	tubulin binding
0.60	GO:0005509	calcium ion binding

0.44

GO:0005829

cytosol

tr|T1EI87|T1EI87_HELRO
Uncharacterized protein
Search

0.86	M-phase inducer phosphatase 2 (Fragment)

0.84	GO:1902751	positive regulation of cell cycle G2/M phase transition
0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.52	GO:0007144	female meiosis I
0.51	GO:0001556	oocyte maturation
0.50	GO:0032467	positive regulation of cytokinesis
0.49	GO:0045931	positive regulation of mitotic cell cycle
0.47	GO:0045860	positive regulation of protein kinase activity
0.42	GO:0006468	protein phosphorylation
0.41	GO:0000086	G2/M transition of mitotic cell cycle
0.40	GO:0051078	meiotic nuclear envelope disassembly

0.75	GO:0004725	protein tyrosine phosphatase activity
0.49	GO:0019901	protein kinase binding
0.40	GO:0050699	WW domain binding

0.48	GO:0005819	spindle
0.47	GO:0005813	centrosome
0.44	GO:0005634	nucleus
0.38	GO:0005737	cytoplasm
0.37	GO:0043233	organelle lumen
0.35	GO:0048475	coated membrane
0.34	GO:0098796	membrane protein complex

0.75

GO:0004725

tr|T1EI88|T1EI88_HELRO
UDP-glucuronosyltransferase
Search

0.28	UDP-glucuronosyltransferase

0.34	GO:0007369	gastrulation
0.34	GO:0006986	response to unfolded protein
0.34	GO:0006635	fatty acid beta-oxidation
0.34	GO:0006979	response to oxidative stress
0.33	GO:0098869	cellular oxidant detoxification
0.33	GO:0016999	antibiotic metabolic process

0.69	GO:0016758	transferase activity, transferring hexosyl groups
0.59	GO:0008194	UDP-glycosyltransferase activity
0.34	GO:0003997	acyl-CoA oxidase activity
0.34	GO:0004601	peroxidase activity
0.33	GO:0020037	heme binding

0.36	GO:0043231	intracellular membrane-bounded organelle
0.32	GO:0044444	cytoplasmic part
0.30	GO:0016020	membrane

0.69	EC:2.4.1	GO:0016758
0.34	KEGG:R03532	GO:0004601

tr|T1EI89|T1EI89_HELRO
Uncharacterized protein
Search

tr|T1EI91|T1EI91_HELRO
Uncharacterized protein
Search

0.86	Hepatocellular carcinoma-associated antigen 90 (Fragment)

0.84	GO:0060236	regulation of mitotic spindle organization
0.80	GO:0032147	activation of protein kinase activity
0.66	GO:0090307	mitotic spindle assembly
0.41	GO:0006915	apoptotic process
0.38	GO:0051301	cell division
0.38	GO:1901796	regulation of signal transduction by p53 class mediator
0.37	GO:0010389	regulation of G2/M transition of mitotic cell cycle
0.37	GO:0008283	cell proliferation
0.36	GO:0006468	protein phosphorylation

0.70	GO:0061676	importin-alpha family protein binding
0.60	GO:0019901	protein kinase binding
0.36	GO:0004672	protein kinase activity
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0032561	guanyl ribonucleotide binding

0.76	GO:0005819	spindle
0.73	GO:0005874	microtubule
0.68	GO:0043203	axon hillock
0.65	GO:0045171	intercellular bridge
0.58	GO:0005815	microtubule organizing center
0.55	GO:0005654	nucleoplasm
0.35	GO:0005829	cytosol

tr|T1EI92|T1EI92_HELRO
Uncharacterized protein
Search

0.10	Putative carboxylesterase (Fragment)

0.60	GO:0050808	synapse organization
0.54	GO:0050804	modulation of chemical synaptic transmission
0.54	GO:0007155	cell adhesion
0.43	GO:0099504	synaptic vesicle cycle
0.43	GO:0099003	vesicle-mediated transport in synapse
0.42	GO:1902805	positive regulation of synaptic vesicle transport
0.42	GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness
0.42	GO:0007399	nervous system development
0.42	GO:0071709	membrane assembly
0.41	GO:1900244	positive regulation of synaptic vesicle endocytosis

0.69	GO:0042043	neurexin family protein binding
0.40	GO:0097110	scaffold protein binding
0.40	GO:0030165	PDZ domain binding
0.40	GO:0052689	carboxylic ester hydrolase activity
0.38	GO:0004872	receptor activity
0.35	GO:0050839	cell adhesion molecule binding
0.34	GO:0046983	protein dimerization activity
0.34	GO:0001540	amyloid-beta binding
0.33	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.33	GO:0020037	heme binding

0.56	GO:0045202	synapse
0.51	GO:0005887	integral component of plasma membrane
0.42	GO:0009986	cell surface
0.38	GO:0097458	neuron part
0.38	GO:0098552	side of membrane
0.36	GO:0032433	filopodium tip
0.36	GO:0098878	neurotransmitter receptor complex
0.36	GO:0098590	plasma membrane region
0.35	GO:0034703	cation channel complex
0.35	GO:0030054	cell junction

0.40	EC:3.1.1 EC:3.1.1.1	GO:0052689
0.40	KEGG:R00630	GO:0052689

tr|T1EI93|T1EI93_HELRO
Uncharacterized protein
Search

0.11	Hypoxia-inducible factor 1-alpha (Fragment)

0.57	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.41	GO:0035225	determination of genital disc primordium
0.41	GO:0007418	ventral midline development
0.41	GO:1902680	positive regulation of RNA biosynthetic process
0.41	GO:0007419	ventral cord development
0.40	GO:0007628	adult walking behavior
0.39	GO:0007411	axon guidance

0.68	GO:0046983	protein dimerization activity
0.57	GO:0003700	DNA binding transcription factor activity
0.44	GO:0003677	DNA binding
0.38	GO:0001067	regulatory region nucleic acid binding
0.34	GO:0003714	transcription corepressor activity
0.34	GO:0003713	transcription coactivator activity
0.34	GO:0003989	acetyl-CoA carboxylase activity

0.67	GO:0005667	transcription factor complex
0.61	GO:0005634	nucleus
0.46	GO:0005737	cytoplasm
0.37	GO:0043233	organelle lumen
0.35	GO:0044446	intracellular organelle part
0.35	GO:0005886	plasma membrane
0.34	GO:0034751	aryl hydrocarbon receptor complex
0.30	GO:0016021	integral component of membrane

0.34

EC:6.4.1.2

GO:0003989

tr|T1EI94|T1EI94_HELRO
Uncharacterized protein
Search

HMG-1.2

0.91	High mobility group protein 1.2

0.55

GO:0003677

DNA binding

0.61	GO:0005634	nucleus
0.30	GO:0044425	membrane part

tr|T1EI95|T1EI95_HELRO
Uncharacterized protein
Search

0.49

GO:0016192

vesicle-mediated transport

0.49	GO:0005576	extracellular region
0.47	GO:0005654	nucleoplasm
0.30	GO:0044425	membrane part

tr|T1EI96|T1EI96_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.42	GO:0007267	cell-cell signaling
0.42	GO:0007399	nervous system development
0.36	GO:0072137	condensed mesenchymal cell proliferation
0.35	GO:0072006	nephron development

0.70

GO:0005509

calcium ion binding

0.56	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

tr|T1EI97|T1EI97_HELRO
Uncharacterized protein
Search

0.85	GO:0071494	cellular response to UV-C
0.85	GO:1901561	response to benomyl
0.85	GO:1990253	cellular response to leucine starvation
0.85	GO:0071264	positive regulation of translational initiation in response to starvation
0.85	GO:0031953	negative regulation of protein autophosphorylation
0.85	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress
0.85	GO:0060733	regulation of eIF2 alpha phosphorylation by amino acid starvation
0.83	GO:0071468	cellular response to acidic pH
0.81	GO:0070301	cellular response to hydrogen peroxide
0.81	GO:1990138	neuron projection extension

0.68	GO:0043022	ribosome binding
0.68	GO:0003779	actin binding
0.49	GO:0004969	histamine receptor activity
0.39	GO:0004860	protein kinase inhibitor activity
0.36	GO:0004799	thymidylate synthase activity

0.79	GO:0005844	polysome
0.40	GO:0005737	cytoplasm
0.35	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016020	membrane

0.36	EC:2.1.1.45	GO:0004799
0.36	KEGG:R02101	GO:0004799

tr|T1EI98|T1EI98_HELRO
Uncharacterized protein
Search

tr|T1EI99|T1EI99_HELRO
Uncharacterized protein
Search

tr|T1EIA0|T1EIA0_HELRO
Uncharacterized protein
Search

tr|T1EIA1|T1EIA1_HELRO
Uncharacterized protein
Search

0.64	Potassium voltage-gated channel subfamily KQT member 5-like (Fragment)

0.73	GO:0071805	potassium ion transmembrane transport
0.52	GO:0060081	membrane hyperpolarization
0.41	GO:0071242	cellular response to ammonium ion
0.40	GO:1905144	response to acetylcholine
0.40	GO:0035690	cellular response to drug
0.39	GO:0032870	cellular response to hormone stimulus
0.38	GO:1901701	cellular response to oxygen-containing compound
0.38	GO:0007186	G-protein coupled receptor signaling pathway
0.36	GO:0034765	regulation of ion transmembrane transport
0.36	GO:0035556	intracellular signal transduction

0.78	GO:0005249	voltage-gated potassium channel activity
0.47	GO:0005516	calmodulin binding
0.34	GO:0044325	ion channel binding
0.34	GO:0031625	ubiquitin protein ligase binding
0.34	GO:0019901	protein kinase binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.52	GO:0043194	axon initial segment
0.51	GO:0033268	node of Ranvier
0.46	GO:0009986	cell surface
0.34	GO:0043025	neuronal cell body
0.34	GO:0030425	dendrite
0.34	GO:0045121	membrane raft
0.33	GO:0005622	intracellular
0.32	GO:0043227	membrane-bounded organelle

tr|T1EIA2|T1EIA2_HELRO
Uncharacterized protein
Search

0.50

Ficolin-1

0.75	GO:0001525	angiogenesis
0.72	GO:0043066	negative regulation of apoptotic process
0.54	GO:0051005	negative regulation of lipoprotein lipase activity
0.52	GO:0070328	triglyceride homeostasis
0.50	GO:2000351	regulation of endothelial cell apoptotic process
0.47	GO:0007596	blood coagulation
0.43	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.43	GO:0019216	regulation of lipid metabolic process
0.41	GO:0006461	protein complex assembly
0.41	GO:0001666	response to hypoxia

0.48	GO:0004857	enzyme inhibitor activity
0.46	GO:0042802	identical protein binding
0.41	GO:0005102	receptor binding
0.41	GO:0005509	calcium ion binding
0.40	GO:0030674	protein binding, bridging
0.38	GO:0050839	cell adhesion molecule binding
0.37	GO:0042302	structural constituent of cuticle
0.37	GO:0030545	receptor regulator activity
0.37	GO:0032403	protein complex binding
0.35	GO:0003723	RNA binding

0.69	GO:0005615	extracellular space
0.40	GO:0005578	proteinaceous extracellular matrix
0.38	GO:0005769	early endosome
0.37	GO:0009986	cell surface
0.36	GO:0005794	Golgi apparatus
0.36	GO:0043234	protein complex
0.30	GO:0016020	membrane

tr|T1EIA3|T1EIA3_HELRO
Uncharacterized protein
Search

0.80	Negative cofactor 2 transcriptional co-repressor (Fragment)

0.46	GO:0051123	RNA polymerase II transcriptional preinitiation complex assembly
0.45	GO:0000122	negative regulation of transcription by RNA polymerase II
0.43	GO:0045944	positive regulation of transcription by RNA polymerase II

0.74	GO:0046982	protein heterodimerization activity
0.47	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
0.46	GO:0042802	identical protein binding
0.43	GO:0008134	transcription factor binding
0.37	GO:0003714	transcription corepressor activity
0.34	GO:0003677	DNA binding
0.33	GO:0003899	DNA-directed 5'-3' RNA polymerase activity

0.59

GO:0005634

nucleus

0.33

GO:0003899

tr|T1EIA4|T1EIA4_HELRO
Uncharacterized protein
Search

0.84	M-phase inducer phosphatase (Fragment)

0.84	GO:1902751	positive regulation of cell cycle G2/M phase transition
0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.49	GO:0007346	regulation of mitotic cell cycle
0.49	GO:0007144	female meiosis I
0.48	GO:0001556	oocyte maturation
0.47	GO:0032467	positive regulation of cytokinesis
0.45	GO:0045995	regulation of embryonic development
0.45	GO:0045860	positive regulation of protein kinase activity
0.43	GO:0010256	endomembrane system organization
0.42	GO:0060305	regulation of cell diameter

0.75	GO:0004725	protein tyrosine phosphatase activity
0.45	GO:0019901	protein kinase binding
0.34	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.34	GO:0050699	WW domain binding
0.33	GO:0004792	thiosulfate sulfurtransferase activity

0.47	GO:0005819	spindle
0.45	GO:0005813	centrosome
0.43	GO:0005634	nucleus
0.37	GO:0005694	chromosome
0.36	GO:0005737	cytoplasm
0.34	GO:0048475	coated membrane
0.34	GO:0043233	organelle lumen
0.33	GO:0098796	membrane protein complex
0.30	GO:0016021	integral component of membrane

0.75	EC:3.1.3.48	GO:0004725
0.33	KEGG:R01931	GO:0004792

tr|T1EIA5|T1EIA5_HELRO
Uncharacterized protein
Search

tr|T1EIA6|T1EIA6_HELRO
Uncharacterized protein
Search

0.46	GO:1903506	regulation of nucleic acid-templated transcription
0.46	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.45	GO:0010468	regulation of gene expression
0.40	GO:0060216	definitive hemopoiesis
0.36	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage

0.51	GO:0003676	nucleic acid binding
0.45	GO:0046872	metal ion binding
0.37	GO:0003700	DNA binding transcription factor activity

0.40	GO:0005634	nucleus
0.34	GO:0012505	endomembrane system
0.34	GO:0044446	intracellular organelle part
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0031090	organelle membrane
0.33	GO:0031975	envelope

tr|T1EIA7|T1EIA7_HELRO
Uncharacterized protein
Search

0.61	GO:0007165	signal transduction
0.60	GO:0034220	ion transmembrane transport
0.43	GO:0006821	chloride transport
0.36	GO:0060012	synaptic transmission, glycinergic
0.35	GO:0043200	response to amino acid
0.35	GO:0060078	regulation of postsynaptic membrane potential
0.34	GO:0071773	cellular response to BMP stimulus
0.34	GO:0060828	regulation of canonical Wnt signaling pathway
0.33	GO:0048513	animal organ development
0.33	GO:0006357	regulation of transcription by RNA polymerase II

0.76	GO:0004890	GABA-A receptor activity
0.74	GO:0005230	extracellular ligand-gated ion channel activity
0.43	GO:0099095	ligand-gated anion channel activity
0.41	GO:0005254	chloride channel activity
0.39	GO:0022835	transmitter-gated channel activity
0.36	GO:0016594	glycine binding
0.34	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
0.33	GO:0044877	macromolecular complex binding
0.33	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0005507	copper ion binding

0.54	GO:0005886	plasma membrane
0.42	GO:1902711	GABA-A receptor complex
0.37	GO:0098794	postsynapse
0.36	GO:0034707	chloride channel complex
0.35	GO:0030054	cell junction

0.34

EC:1.14.17

GO:0016715

tr|T1EIA8|T1EIA8_HELRO
Uncharacterized protein
Search

MRPS10

0.88	Mitochondrial ribosomal protein S10

0.50	GO:0043043	peptide biosynthetic process
0.47	GO:0044267	cellular protein metabolic process
0.46	GO:0010467	gene expression
0.45	GO:0009059	macromolecule biosynthetic process
0.34	GO:0043624	cellular protein complex disassembly

0.53	GO:0003735	structural constituent of ribosome
0.33	GO:0003723	RNA binding
0.32	GO:0016787	hydrolase activity

0.59	GO:0005840	ribosome
0.50	GO:0005759	mitochondrial matrix
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0019866	organelle inner membrane

0.32

GO:0016787

tr|T1EIA9|T1EIA9_HELRO
Uncharacterized protein
Search

0.10	ATPase, Na+/K+ transporting, alpha 1b polypeptide (Fragment)

0.83	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
0.74	GO:0090662	ATP hydrolysis coupled transmembrane transport
0.71	GO:0006814	sodium ion transport
0.70	GO:0006813	potassium ion transport
0.43	GO:0030317	flagellated sperm motility
0.43	GO:0030641	regulation of cellular pH
0.42	GO:0009566	fertilization
0.42	GO:0007283	spermatogenesis
0.41	GO:0042391	regulation of membrane potential
0.38	GO:0010084	specification of animal organ axis polarity

0.83	GO:0005391	sodium:potassium-exchanging ATPase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0046872	metal ion binding
0.34	GO:0005388	calcium-transporting ATPase activity
0.32	GO:0016301	kinase activity

0.34	GO:0042383	sarcolemma
0.34	GO:0005890	sodium:potassium-exchanging ATPase complex
0.32	GO:0043227	membrane-bounded organelle
0.32	GO:0043229	intracellular organelle

0.83

EC:3.6.3.9

GO:0005391

tr|T1EIB0|T1EIB0_HELRO
Uncharacterized protein
Search

0.10	Parathyroid hormone receptor (Fragment)

0.71	GO:0007166	cell surface receptor signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.55	GO:0009755	hormone-mediated signaling pathway
0.42	GO:0009651	response to salt stress
0.35	GO:0071377	cellular response to glucagon stimulus
0.34	GO:0008284	positive regulation of cell proliferation
0.32	GO:0006508	proteolysis

0.72	GO:0004930	G-protein coupled receptor activity
0.62	GO:0008036	diuretic hormone receptor activity
0.40	GO:0001653	peptide receptor activity
0.32	GO:0004222	metalloendopeptidase activity

0.50	GO:0005886	plasma membrane
0.36	GO:0005881	cytoplasmic microtubule
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0004222

tr|T1EIB1|T1EIB1_HELRO
Uncharacterized protein
Search

PTK2

0.67	Protein-tyrosine kinase 2-beta (Fragment)

0.86	GO:0007172	signal complex assembly
0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.72	GO:0030278	regulation of ossification
0.68	GO:0030334	regulation of cell migration
0.68	GO:2000249	regulation of actin cytoskeleton reorganization
0.67	GO:0070167	regulation of biomineral tissue development
0.67	GO:0042127	regulation of cell proliferation
0.67	GO:0030155	regulation of cell adhesion
0.65	GO:0045765	regulation of angiogenesis
0.65	GO:0050920	regulation of chemotaxis

0.77	GO:0004713	protein tyrosine kinase activity
0.64	GO:0004871	signal transducer activity
0.56	GO:0008432	JUN kinase binding
0.54	GO:0042169	SH2 domain binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0008022	protein C-terminus binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0003779	actin binding

0.82	GO:0005925	focal adhesion
0.66	GO:0005856	cytoskeleton
0.65	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.61	GO:0030027	lamellipodium
0.51	GO:0048471	perinuclear region of cytoplasm
0.50	GO:0016324	apical plasma membrane
0.49	GO:0005634	nucleus
0.47	GO:0005829	cytosol
0.44	GO:0097440	apical dendrite
0.43	GO:0017146	NMDA selective glutamate receptor complex

0.77

GO:0004713

tr|T1EIB2|T1EIB2_HELRO
Uncharacterized protein
Search

0.81	Pangolin isoform B (Fragment)

0.76	GO:0016055	Wnt signaling pathway
0.51	GO:0006357	regulation of transcription by RNA polymerase II
0.40	GO:0002681	somatic recombination of T cell receptor gene segments
0.38	GO:0033151	V(D)J recombination
0.35	GO:1904837	beta-catenin-TCF complex assembly
0.35	GO:0009790	embryo development
0.35	GO:0009888	tissue development
0.34	GO:0035112	genitalia morphogenesis
0.34	GO:0071353	cellular response to interleukin-4
0.34	GO:2000036	regulation of stem cell population maintenance

0.58	GO:0008013	beta-catenin binding
0.55	GO:0003677	DNA binding
0.42	GO:0001067	regulatory region nucleic acid binding
0.37	GO:0016757	transferase activity, transferring glycosyl groups
0.34	GO:0003700	DNA binding transcription factor activity
0.34	GO:0003682	chromatin binding

0.61	GO:0005634	nucleus
0.42	GO:0005667	transcription factor complex
0.41	GO:0005829	cytosol
0.41	GO:0043233	organelle lumen
0.38	GO:0044446	intracellular organelle part
0.33	GO:0005694	chromosome
0.30	GO:0031224	intrinsic component of membrane

0.37

GO:0016757

tr|T1EIB3|T1EIB3_HELRO
Uncharacterized protein
Search

0.50

Tenascin

0.75	GO:0001525	angiogenesis
0.72	GO:0043066	negative regulation of apoptotic process
0.54	GO:0051005	negative regulation of lipoprotein lipase activity
0.52	GO:0070328	triglyceride homeostasis
0.51	GO:2000351	regulation of endothelial cell apoptotic process
0.47	GO:0007596	blood coagulation
0.43	GO:0019216	regulation of lipid metabolic process
0.42	GO:0007155	cell adhesion
0.41	GO:0006461	protein complex assembly
0.41	GO:0001666	response to hypoxia

0.48	GO:0004857	enzyme inhibitor activity
0.46	GO:0042802	identical protein binding
0.40	GO:0005102	receptor binding
0.40	GO:0030674	protein binding, bridging
0.40	GO:0005509	calcium ion binding
0.38	GO:0050839	cell adhesion molecule binding
0.37	GO:0001104	RNA polymerase II transcription cofactor activity
0.37	GO:0030545	receptor regulator activity
0.37	GO:0032403	protein complex binding
0.35	GO:0003723	RNA binding

0.69	GO:0005615	extracellular space
0.40	GO:0005578	proteinaceous extracellular matrix
0.38	GO:0005769	early endosome
0.37	GO:0043234	protein complex
0.37	GO:0009986	cell surface
0.36	GO:0005794	Golgi apparatus
0.36	GO:0044451	nucleoplasm part
0.30	GO:0016020	membrane

tr|T1EIB4|T1EIB4_HELRO
Uncharacterized protein
Search

0.90	Homeobox protein Nkx-6.1 (Fragment)

0.71	GO:0002067	glandular epithelial cell differentiation
0.66	GO:0031018	endocrine pancreas development
0.64	GO:0030516	regulation of axon extension
0.64	GO:0001764	neuron migration
0.64	GO:0050796	regulation of insulin secretion
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:0045165	cell fate commitment
0.56	GO:0010468	regulation of gene expression
0.54	GO:0021522	spinal cord motor neuron differentiation

0.64	GO:0043565	sequence-specific DNA binding
0.50	GO:0003700	DNA binding transcription factor activity
0.36	GO:0001012	RNA polymerase II regulatory region DNA binding
0.36	GO:0003682	chromatin binding
0.36	GO:0003690	double-stranded DNA binding
0.33	GO:0003924	GTPase activity
0.33	GO:0005525	GTP binding

0.61	GO:0005634	nucleus
0.36	GO:0070062	extracellular exosome
0.34	GO:0005874	microtubule
0.33	GO:0005829	cytosol

tr|T1EIB5|T1EIB5_HELRO
Superoxide dismutase [Cu-Zn]
Search

0.30	Superoxide dismutase [Cu-Zn]

0.74	GO:0006801	superoxide metabolic process
0.74	GO:0071450	cellular response to oxygen radical
0.74	GO:0000303	response to superoxide
0.68	GO:0098869	cellular oxidant detoxification
0.52	GO:0055114	oxidation-reduction process
0.41	GO:0071457	cellular response to ozone
0.41	GO:0071484	cellular response to light intensity
0.40	GO:0071493	cellular response to UV-B
0.40	GO:0006882	cellular zinc ion homeostasis
0.40	GO:0071472	cellular response to salt stress

0.76	GO:0004784	superoxide dismutase activity
0.53	GO:0046872	metal ion binding
0.34	GO:0003735	structural constituent of ribosome
0.34	GO:0004601	peroxidase activity

0.40	GO:0005615	extracellular space
0.39	GO:0009536	plastid
0.38	GO:0005758	mitochondrial intermembrane space
0.37	GO:0048046	apoplast
0.36	GO:0005829	cytosol
0.35	GO:0042579	microbody
0.35	GO:0009579	thylakoid
0.35	GO:0005773	vacuole
0.35	GO:0005634	nucleus
0.35	GO:0015934	large ribosomal subunit

0.76	EC:1.15.1.1	GO:0004784
0.34	KEGG:R03532	GO:0004601

tr|T1EIB6|T1EIB6_HELRO
Uncharacterized protein
Search

0.75	GO:0051260	protein homooligomerization
0.75	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.54	GO:0086052	membrane repolarization during SA node cell action potential
0.54	GO:0086050	membrane repolarization during bundle of His cell action potential
0.53	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential
0.52	GO:0060081	membrane hyperpolarization
0.51	GO:0086091	regulation of heart rate by cardiac conduction
0.50	GO:0043267	negative regulation of potassium ion transport
0.49	GO:0019229	regulation of vasoconstriction

0.78	GO:0005249	voltage-gated potassium channel activity
0.51	GO:0019870	potassium channel inhibitor activity
0.51	GO:0051393	alpha-actinin binding
0.51	GO:0097110	scaffold protein binding
0.47	GO:0019901	protein kinase binding
0.36	GO:0005102	receptor binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.50	GO:0014704	intercalated disc
0.48	GO:0045121	membrane raft
0.39	GO:0046691	intracellular canaliculus
0.37	GO:0030018	Z disc
0.36	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0005794	Golgi apparatus
0.35	GO:0005783	endoplasmic reticulum

tr|T1EIB7|T1EIB7_HELRO
Uncharacterized protein
Search

YMDB

0.44	Macro domain-containing protein LIC

0.48	GO:0006470	protein dephosphorylation
0.43	GO:0080009	mRNA methylation
0.43	GO:0060701	negative regulation of ribonuclease activity
0.40	GO:0001172	transcription, RNA-templated
0.40	GO:0039694	viral RNA genome replication
0.40	GO:0060332	positive regulation of response to interferon-gamma
0.40	GO:0035563	positive regulation of chromatin binding
0.40	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining
0.40	GO:0060334	regulation of interferon-gamma-mediated signaling pathway
0.40	GO:0006396	RNA processing

0.51	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.49	GO:0003950	NAD+ ADP-ribosyltransferase activity
0.43	GO:0004857	enzyme inhibitor activity
0.43	GO:0003723	RNA binding
0.43	GO:0008174	mRNA methyltransferase activity
0.41	GO:0072570	ADP-D-ribose binding
0.41	GO:0008234	cysteine-type peptidase activity
0.41	GO:0019213	deacetylase activity
0.41	GO:0003968	RNA-directed 5'-3' RNA polymerase activity
0.40	GO:0097677	STAT family protein binding

0.40	GO:0033644	host cell membrane
0.39	GO:0090734	site of DNA damage
0.38	GO:0000808	origin recognition complex
0.37	GO:0005634	nucleus
0.36	GO:0005829	cytosol
0.36	GO:0070013	intracellular organelle lumen
0.35	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

0.51

EC:3.1.3

GO:0008138

tr|T1EIB8|T1EIB8_HELRO
Uncharacterized protein
Search

0.80	Putative rna-binding protein etr-3 rrm superfamily (Fragment)

0.47	GO:0040018	positive regulation of multicellular organism growth
0.46	GO:0006376	mRNA splice site selection
0.46	GO:0007286	spermatid development
0.37	GO:0046835	carbohydrate phosphorylation
0.37	GO:0043484	regulation of RNA splicing
0.37	GO:0017148	negative regulation of translation
0.35	GO:0006413	translational initiation
0.35	GO:0050684	regulation of mRNA processing

0.59	GO:0003723	RNA binding
0.46	GO:0031369	translation initiation factor binding
0.38	GO:0004747	ribokinase activity

0.42	GO:0005654	nucleoplasm
0.36	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.38

EC:2.7.1.15

GO:0004747

tr|T1EIB9|T1EIB9_HELRO
POU domain protein
Search

0.51	POU domain protein (Fragment)

0.58	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.43	GO:0014019	neuroblast development
0.43	GO:0007398	ectoderm development
0.41	GO:0007417	central nervous system development
0.40	GO:1902680	positive regulation of RNA biosynthetic process
0.35	GO:0002806	negative regulation of antimicrobial peptide biosynthetic process
0.35	GO:0002787	negative regulation of antibacterial peptide production

0.63	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.34	GO:0044212	transcription regulatory region DNA binding
0.33	GO:0003690	double-stranded DNA binding

0.61

GO:0005634

nucleus

tr|T1EIC0|T1EIC0_HELRO
Uncharacterized protein
Search

tr|T1EIC1|T1EIC1_HELRO
Uncharacterized protein
Search

0.55	Myeloid/lymphoid or mixed-lineage leukemia (Fragment)

0.79	GO:0051568	histone H3-K4 methylation
0.56	GO:1901674	regulation of histone H3-K27 acetylation
0.55	GO:2001040	positive regulation of cellular response to drug
0.54	GO:0018023	peptidyl-lysine trimethylation
0.54	GO:0048172	regulation of short-term neuronal synaptic plasticity
0.54	GO:0051569	regulation of histone H3-K4 methylation
0.54	GO:2001141	regulation of RNA biosynthetic process
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0043984	histone H4-K16 acetylation
0.54	GO:0071440	regulation of histone H3-K14 acetylation

0.81	GO:0042800	histone methyltransferase activity (H3-K4 specific)
0.61	GO:0008270	zinc ion binding
0.54	GO:0045322	unmethylated CpG binding
0.53	GO:0070577	lysine-acetylated histone binding
0.52	GO:0001046	core promoter sequence-specific DNA binding
0.49	GO:0003682	chromatin binding
0.48	GO:0042803	protein homodimerization activity
0.38	GO:0003700	DNA binding transcription factor activity
0.35	GO:0003680	AT DNA binding
0.35	GO:0034450	ubiquitin-ubiquitin ligase activity

0.78	GO:0071339	MLL1 complex
0.46	GO:0005829	cytosol
0.36	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
0.34	GO:0000151	ubiquitin ligase complex

0.33

GO:0003899

tr|T1EIC2|T1EIC2_HELRO
Uncharacterized protein
Search

tr|T1EIC3|T1EIC3_HELRO
Uncharacterized protein
Search

0.44	PR domain zinc finger protein 14 (Fragment)

0.54	GO:0034972	histone H3-R26 methylation
0.52	GO:1902459	positive regulation of stem cell population maintenance
0.52	GO:0060817	inactivation of paternal X chromosome
0.52	GO:1902093	positive regulation of flagellated sperm motility
0.52	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
0.51	GO:0044030	regulation of DNA methylation
0.51	GO:0048873	homeostasis of number of cells within a tissue
0.51	GO:0030718	germ-line stem cell population maintenance
0.50	GO:0001827	inner cell mass cell fate commitment
0.50	GO:0048468	cell development

0.51	GO:0003676	nucleic acid binding
0.47	GO:0003682	chromatin binding
0.35	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
0.35	GO:0035257	nuclear hormone receptor binding
0.34	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.34	GO:0008168	methyltransferase activity
0.34	GO:0046872	metal ion binding
0.33	GO:0046983	protein dimerization activity
0.32	GO:0005215	transporter activity

0.45	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0008168

tr|T1EIC4|T1EIC4_HELRO
Uncharacterized protein
Search

0.45

Tenascin

0.75	GO:0001525	angiogenesis
0.72	GO:0043066	negative regulation of apoptotic process
0.52	GO:0051005	negative regulation of lipoprotein lipase activity
0.51	GO:2000351	regulation of endothelial cell apoptotic process
0.51	GO:0070328	triglyceride homeostasis
0.47	GO:0007596	blood coagulation
0.43	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.42	GO:0006461	protein complex assembly
0.41	GO:0001666	response to hypoxia
0.41	GO:0019216	regulation of lipid metabolic process

0.47	GO:0004857	enzyme inhibitor activity
0.46	GO:0042802	identical protein binding
0.41	GO:0005509	calcium ion binding
0.40	GO:0030674	protein binding, bridging
0.39	GO:0005102	receptor binding
0.38	GO:0001104	RNA polymerase II transcription cofactor activity
0.35	GO:0003723	RNA binding

0.69	GO:0005615	extracellular space
0.40	GO:0005578	proteinaceous extracellular matrix
0.38	GO:0043234	protein complex
0.37	GO:0044451	nucleoplasm part
0.30	GO:0016020	membrane

tr|T1EIC5|T1EIC5_HELRO
Uncharacterized protein
Search

0.71	GO:0031338	regulation of vesicle fusion
0.71	GO:0090630	activation of GTPase activity
0.60	GO:0006886	intracellular protein transport
0.44	GO:0035526	retrograde transport, plasma membrane to Golgi
0.43	GO:0007049	cell cycle
0.43	GO:0048227	plasma membrane to endosome transport
0.43	GO:1903358	regulation of Golgi organization
0.41	GO:0007030	Golgi organization
0.39	GO:0019068	virion assembly

0.68	GO:0017137	Rab GTPase binding
0.68	GO:0005096	GTPase activator activity
0.42	GO:0016787	hydrolase activity

0.58	GO:0012505	endomembrane system
0.41	GO:0005622	intracellular
0.39	GO:0031982	vesicle
0.36	GO:0005886	plasma membrane

0.42

GO:0016787

tr|T1EIC6|T1EIC6_HELRO
Uncharacterized protein
Search

0.10	Voltage-dependent calcium channel subunit alpha-2/delta-3 (Fragment)

0.75	GO:0050965	detection of temperature stimulus involved in sensory perception of pain
0.74	GO:0045886	negative regulation of synaptic growth at neuromuscular junction
0.72	GO:0097352	autophagosome maturation
0.72	GO:0048488	synaptic vesicle endocytosis
0.72	GO:0007274	neuromuscular synaptic transmission
0.71	GO:0007528	neuromuscular junction development
0.40	GO:0070588	calcium ion transmembrane transport

0.41

GO:0005245

voltage-gated calcium channel activity

0.69	GO:0048786	presynaptic active zone
0.30	GO:0016020	membrane

tr|T1EIC7|T1EIC7_HELRO
Uncharacterized protein
Search

0.86	RNA binding protein fox-1-like protein (Fragment)

0.49	GO:0030706	germarium-derived oocyte differentiation
0.49	GO:0007474	imaginal disc-derived wing vein specification
0.47	GO:0007613	memory
0.45	GO:0017148	negative regulation of translation
0.44	GO:0007399	nervous system development
0.44	GO:0045893	positive regulation of transcription, DNA-templated
0.40	GO:0043484	regulation of RNA splicing
0.36	GO:0008380	RNA splicing
0.35	GO:0006397	mRNA processing
0.35	GO:0050684	regulation of mRNA processing

0.59	GO:0003723	RNA binding
0.45	GO:0044212	transcription regulatory region DNA binding
0.44	GO:0008134	transcription factor binding

0.41	GO:0005634	nucleus
0.39	GO:0043233	organelle lumen
0.36	GO:0044446	intracellular organelle part
0.36	GO:0005737	cytoplasm

tr|T1EIC8|T1EIC8_HELRO
Uncharacterized protein
Search

0.62	V-erb-a erythroblastic leukemia viral oncogene homolog 4 (Avian) (Fragment)

0.77	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.59	GO:0023014	signal transduction by protein phosphorylation
0.56	GO:0035556	intracellular signal transduction
0.49	GO:0055025	positive regulation of cardiac muscle tissue development
0.48	GO:0060485	mesenchyme development
0.47	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
0.47	GO:0061026	cardiac muscle tissue regeneration
0.47	GO:2000366	positive regulation of STAT protein import into nucleus
0.47	GO:2001223	negative regulation of neuron migration

0.79	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.77	GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0008144	drug binding
0.46	GO:0005154	epidermal growth factor receptor binding
0.44	GO:0042802	identical protein binding
0.43	GO:0044212	transcription regulatory region DNA binding
0.43	GO:0046983	protein dimerization activity

0.47	GO:0016323	basolateral plasma membrane
0.46	GO:0043235	receptor complex
0.42	GO:0005622	intracellular
0.41	GO:0016328	lateral plasma membrane
0.40	GO:0016324	apical plasma membrane
0.38	GO:0005615	extracellular space
0.37	GO:0043227	membrane-bounded organelle
0.34	GO:0005887	integral component of plasma membrane
0.34	GO:0005901	caveola
0.33	GO:0014069	postsynaptic density

0.79	EC:2.7.10.1	GO:0004714
0.34	KEGG:R04545	GO:0046934

tr|T1EIC9|T1EIC9_HELRO
Uncharacterized protein
Search

0.74	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
0.38	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.38	GO:0006401	RNA catabolic process
0.37	GO:0006364	rRNA processing
0.36	GO:1903506	regulation of nucleic acid-templated transcription

0.77	GO:0008859	exoribonuclease II activity
0.54	GO:0003723	RNA binding
0.41	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
0.40	GO:0004519	endonuclease activity
0.39	GO:0000175	3'-5'-exoribonuclease activity
0.37	GO:0004386	helicase activity
0.35	GO:0046872	metal ion binding

0.45	GO:0005737	cytoplasm
0.39	GO:0000178	exosome (RNase complex)

0.77

EC:3.1.13.1

GO:0008859

tr|T1EID0|T1EID0_HELRO
Uncharacterized protein
Search

0.72	GO:0045892	negative regulation of transcription, DNA-templated
0.51	GO:0045820	negative regulation of glycolytic process
0.50	GO:1903715	regulation of aerobic respiration
0.50	GO:0030851	granulocyte differentiation
0.48	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.48	GO:0001666	response to hypoxia
0.47	GO:0008285	negative regulation of cell proliferation
0.38	GO:0045599	negative regulation of fat cell differentiation
0.37	GO:0045444	fat cell differentiation
0.37	GO:0051101	regulation of DNA binding

0.81	GO:0003714	transcription corepressor activity
0.61	GO:0003700	DNA binding transcription factor activity
0.36	GO:0003682	chromatin binding
0.36	GO:0005515	protein binding
0.34	GO:0003677	DNA binding
0.34	GO:0046872	metal ion binding

0.47	GO:0005654	nucleoplasm
0.38	GO:0016363	nuclear matrix
0.35	GO:0000139	Golgi membrane
0.35	GO:0005730	nucleolus
0.34	GO:0017053	transcriptional repressor complex

tr|T1EID1|T1EID1_HELRO
Uncharacterized protein
Search

tr|T1EID2|T1EID2_HELRO
Uncharacterized protein
Search

0.38

GO:0042758

long-chain fatty acid catabolic process

0.33

GO:0016787

hydrolase activity

0.35	GO:0012505	endomembrane system
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0016787

tr|T1EID3|T1EID3_HELRO
Uncharacterized protein
Search

0.37	Voltage-gated potassium channel

0.78	GO:0051260	protein homooligomerization
0.75	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.35	GO:0030431	sleep
0.34	GO:0006379	mRNA cleavage
0.32	GO:0006351	transcription, DNA-templated

0.78	GO:0005249	voltage-gated potassium channel activity
0.35	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.33	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.33	GO:0046872	metal ion binding
0.32	GO:0003676	nucleic acid binding

0.78

GO:0008076

voltage-gated potassium channel complex

0.35

GO:0004114

tr|T1EID4|T1EID4_HELRO
Uncharacterized protein
Search

TIGD6

0.50	Tigger transposable element-derived protein 6

0.34	GO:2001154	regulation of glycolytic fermentation to ethanol
0.34	GO:0090180	positive regulation of thiamine biosynthetic process
0.33	GO:0051197	positive regulation of coenzyme metabolic process
0.33	GO:1903580	positive regulation of ATP metabolic process
0.33	GO:0015074	DNA integration
0.33	GO:0010907	positive regulation of glucose metabolic process
0.33	GO:0045944	positive regulation of transcription by RNA polymerase II
0.32	GO:0055085	transmembrane transport

0.52	GO:0003677	DNA binding
0.33	GO:0003682	chromatin binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0001067	regulatory region nucleic acid binding
0.30	GO:0003824	catalytic activity

0.40	GO:0005634	nucleus
0.34	GO:0005721	pericentric heterochromatin
0.34	GO:0000779	condensed chromosome, centromeric region
0.33	GO:0031974	membrane-enclosed lumen

tr|T1EID5|T1EID5_HELRO
Uncharacterized protein
Search

0.54	GO:0035583	sequestering of TGFbeta in extracellular matrix
0.52	GO:0060346	bone trabecula formation
0.51	GO:0048048	embryonic eye morphogenesis
0.51	GO:0030501	positive regulation of bone mineralization
0.50	GO:0045669	positive regulation of osteoblast differentiation
0.50	GO:0030326	embryonic limb morphogenesis
0.50	GO:0043010	camera-type eye development
0.45	GO:0030198	extracellular matrix organization
0.40	GO:0007219	Notch signaling pathway
0.39	GO:0007155	cell adhesion

0.70	GO:0005509	calcium ion binding
0.66	GO:0005201	extracellular matrix structural constituent
0.39	GO:0005102	receptor binding
0.38	GO:0008201	heparin binding
0.37	GO:0050839	cell adhesion molecule binding
0.37	GO:0098772	molecular function regulator
0.37	GO:0008022	protein C-terminus binding
0.37	GO:0032403	protein complex binding
0.36	GO:0042802	identical protein binding
0.36	GO:0017147	Wnt-protein binding

0.63	GO:0031012	extracellular matrix
0.46	GO:0099512	supramolecular fiber
0.42	GO:0005615	extracellular space
0.38	GO:0005927	muscle tendon junction
0.36	GO:0005737	cytoplasm
0.36	GO:0043235	receptor complex
0.35	GO:0043234	protein complex
0.34	GO:1903561	extracellular vesicle
0.33	GO:0098805	whole membrane
0.33	GO:0098588	bounding membrane of organelle

0.35

GO:0004190

tr|T1EID6|T1EID6_HELRO
Uncharacterized protein
Search

0.70	Transcription factor Sp5 (Fragment)

0.49	GO:0048332	mesoderm morphogenesis
0.45	GO:0036342	post-anal tail morphogenesis
0.44	GO:0030903	notochord development
0.44	GO:0006357	regulation of transcription by RNA polymerase II
0.44	GO:0048598	embryonic morphogenesis
0.44	GO:0003002	regionalization
0.43	GO:0030902	hindbrain development
0.42	GO:0016055	Wnt signaling pathway
0.41	GO:0048646	anatomical structure formation involved in morphogenesis
0.38	GO:0035108	limb morphogenesis

0.51	GO:0003676	nucleic acid binding
0.45	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.32	GO:0046872	metal ion binding

0.41	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EID7|T1EID7_HELRO
Uncharacterized protein
Search

0.46	Collagen, type VIII, alpha 1b (Fragment)

0.53	GO:0009888	tissue development
0.53	GO:0060538	skeletal muscle organ development
0.53	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
0.52	GO:0007626	locomotory behavior
0.51	GO:0071560	cellular response to transforming growth factor beta stimulus
0.47	GO:0014823	response to activity
0.45	GO:0001704	formation of primary germ layer
0.45	GO:0016525	negative regulation of angiogenesis
0.44	GO:0007568	aging
0.42	GO:0030154	cell differentiation

0.60

GO:0005201

extracellular matrix structural constituent

0.69	GO:0005581	collagen trimer
0.54	GO:0098645	collagen network
0.51	GO:0005604	basement membrane
0.47	GO:0005615	extracellular space

tr|T1EID8|T1EID8_HELRO
Uncharacterized protein
Search

BTG1

0.93	B-cell translocation protein 1, anti-proliferative

0.75	GO:0008285	negative regulation of cell proliferation
0.55	GO:2000271	positive regulation of fibroblast apoptotic process
0.54	GO:0045603	positive regulation of endothelial cell differentiation
0.53	GO:0045663	positive regulation of myoblast differentiation
0.52	GO:0045766	positive regulation of angiogenesis
0.45	GO:0007611	learning or memory
0.43	GO:0008213	protein alkylation
0.43	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
0.42	GO:0021542	dentate gyrus development
0.42	GO:0035914	skeletal muscle cell differentiation

0.47	GO:0019899	enzyme binding
0.35	GO:0003712	transcription cofactor activity
0.34	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding

0.43	GO:0005634	nucleus
0.40	GO:0044297	cell body
0.40	GO:0097060	synaptic membrane
0.38	GO:0005737	cytoplasm
0.34	GO:0070062	extracellular exosome

tr|T1EID9|T1EID9_HELRO
Uncharacterized protein
Search

0.50	Muscarinic acetylcholine receptor (Fragment)

0.84	GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
0.80	GO:0046541	saliva secretion
0.77	GO:0045987	positive regulation of smooth muscle contraction
0.50	GO:0001696	gastric acid secretion
0.49	GO:0003056	regulation of vascular smooth muscle contraction
0.49	GO:0007271	synaptic transmission, cholinergic
0.48	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.48	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
0.47	GO:0006939	smooth muscle contraction
0.43	GO:0050877	nervous system process

0.85	GO:0016907	G-protein coupled acetylcholine receptor activity
0.43	GO:0042166	acetylcholine binding
0.34	GO:0005515	protein binding
0.34	GO:0004435	phosphatidylinositol phospholipase C activity
0.33	GO:0098772	molecular function regulator

0.78	GO:0045211	postsynaptic membrane
0.74	GO:0030054	cell junction
0.66	GO:0005887	integral component of plasma membrane
0.41	GO:0016323	basolateral plasma membrane
0.39	GO:0043679	axon terminus
0.39	GO:0032279	asymmetric synapse
0.38	GO:0030425	dendrite

0.34	EC:3.1.4.11	GO:0004435
0.34	KEGG:R03435	GO:0004435

tr|T1EIE0|T1EIE0_HELRO
Uncharacterized protein
Search

0.69	Transcription factor Sp9 (Fragment)

0.52	GO:0001649	osteoblast differentiation
0.49	GO:2000738	positive regulation of stem cell differentiation
0.49	GO:0060218	hematopoietic stem cell differentiation
0.46	GO:0006357	regulation of transcription by RNA polymerase II
0.45	GO:0006366	transcription by RNA polymerase II
0.45	GO:0060363	cranial suture morphogenesis
0.44	GO:0033688	regulation of osteoblast proliferation
0.44	GO:0045893	positive regulation of transcription, DNA-templated
0.36	GO:0036342	post-anal tail morphogenesis
0.35	GO:0071407	cellular response to organic cyclic compound

0.51	GO:0003676	nucleic acid binding
0.50	GO:0017151	DEAD/H-box RNA helicase binding
0.47	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.33	GO:0046872	metal ion binding

0.42	GO:0005634	nucleus
0.36	GO:0005737	cytoplasm
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part

tr|T1EIE1|T1EIE1_HELRO
Uncharacterized protein
Search

0.55	GO:0043484	regulation of RNA splicing
0.46	GO:0008380	RNA splicing
0.44	GO:0006397	mRNA processing
0.39	GO:0050684	regulation of mRNA processing
0.38	GO:0007399	nervous system development
0.33	GO:0060047	heart contraction
0.33	GO:0060322	head development
0.33	GO:0048513	animal organ development
0.32	GO:0032259	methylation

0.59	GO:0003723	RNA binding
0.32	GO:0008168	methyltransferase activity
0.32	GO:0005515	protein binding
0.32	GO:0003677	DNA binding

0.43	GO:0005634	nucleus
0.36	GO:0043186	P granule
0.34	GO:0043204	perikaryon
0.30	GO:0016020	membrane

0.32

GO:0008168

tr|T1EIE2|T1EIE2_HELRO
Uncharacterized protein
Search

tr|T1EIE3|T1EIE3_HELRO
Uncharacterized protein
Search

0.76	GO:0006915	apoptotic process
0.67	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.66	GO:0019051	induction by virus of host apoptotic process
0.61	GO:0006508	proteolysis
0.47	GO:0030225	macrophage differentiation
0.42	GO:0007166	cell surface receptor signaling pathway

0.75

GO:0004197

cysteine-type endopeptidase activity

0.36

GO:0005737

cytoplasm

0.75

EC:3.4.22

GO:0004197

tr|T1EIE4|T1EIE4_HELRO
Uncharacterized protein
Search

0.78	heart- and neural crest derivatives-expressed protein 1

0.57	GO:0003219	cardiac right ventricle formation
0.56	GO:0003218	cardiac left ventricle formation
0.55	GO:0003144	embryonic heart tube formation
0.55	GO:0060536	cartilage morphogenesis
0.54	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
0.53	GO:0001829	trophectodermal cell differentiation
0.53	GO:0055010	ventricular cardiac muscle tissue morphogenesis
0.53	GO:0001947	heart looping
0.53	GO:0043433	negative regulation of DNA binding transcription factor activity
0.53	GO:0060411	cardiac septum morphogenesis

0.68	GO:0046983	protein dimerization activity
0.54	GO:0043425	bHLH transcription factor binding
0.52	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.51	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.50	GO:0003713	transcription coactivator activity
0.48	GO:0042802	identical protein binding
0.46	GO:0019899	enzyme binding
0.38	GO:0003680	AT DNA binding
0.37	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0033613	activating transcription factor binding

0.49	GO:0005667	transcription factor complex
0.47	GO:0005730	nucleolus
0.46	GO:0005654	nucleoplasm
0.38	GO:0005737	cytoplasm
0.36	GO:0000790	nuclear chromatin

tr|T1EIE5|T1EIE5_HELRO
Uncharacterized protein
Search

0.10	Forkhead box protein O (Fragment)

0.57	GO:0006355	regulation of transcription, DNA-templated
0.51	GO:0006351	transcription, DNA-templated
0.45	GO:0042127	regulation of cell proliferation
0.44	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
0.44	GO:0032873	negative regulation of stress-activated MAPK cascade
0.44	GO:0030154	cell differentiation
0.44	GO:2000781	positive regulation of double-strand break repair
0.44	GO:0090344	negative regulation of cell aging
0.43	GO:0071156	regulation of cell cycle arrest
0.43	GO:0000086	G2/M transition of mitotic cell cycle

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.41	GO:0019901	protein kinase binding
0.41	GO:0001012	RNA polymerase II regulatory region DNA binding
0.40	GO:0003690	double-stranded DNA binding
0.35	GO:0008013	beta-catenin binding
0.34	GO:0031490	chromatin DNA binding
0.34	GO:0031625	ubiquitin protein ligase binding
0.33	GO:0042802	identical protein binding
0.33	GO:0008134	transcription factor binding

0.61	GO:0005634	nucleus
0.34	GO:0005737	cytoplasm
0.33	GO:0070013	intracellular organelle lumen
0.33	GO:0044446	intracellular organelle part

0.33

EC:3.2.1.51

GO:0004560

tr|T1EIE6|T1EIE6_HELRO
Uncharacterized protein
Search

0.85	paired box protein Pax-2 isoform X5

0.69	GO:0007275	multicellular organism development
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:0006355	regulation of transcription, DNA-templated
0.37	GO:0002009	morphogenesis of an epithelium
0.37	GO:0045918	negative regulation of cytolysis
0.36	GO:0060788	ectodermal placode formation
0.36	GO:2000378	negative regulation of reactive oxygen species metabolic process
0.36	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.36	GO:0050679	positive regulation of epithelial cell proliferation
0.36	GO:0001763	morphogenesis of a branching structure

0.55	GO:0003677	DNA binding
0.37	GO:0001067	regulatory region nucleic acid binding
0.35	GO:0008134	transcription factor binding
0.34	GO:0005272	sodium channel activity
0.33	GO:0003700	DNA binding transcription factor activity
0.33	GO:0016301	kinase activity

0.61	GO:0005634	nucleus
0.36	GO:0005794	Golgi apparatus
0.36	GO:0034451	centriolar satellite
0.36	GO:0070013	intracellular organelle lumen
0.30	GO:0016020	membrane

tr|T1EIE7|T1EIE7_HELRO
Uncharacterized protein
Search

0.57	GO:0006355	regulation of transcription, DNA-templated
0.55	GO:0006351	transcription, DNA-templated
0.54	GO:0008286	insulin receptor signaling pathway
0.51	GO:0051151	negative regulation of smooth muscle cell differentiation
0.51	GO:0070317	negative regulation of G0 to G1 transition
0.51	GO:0042127	regulation of cell proliferation
0.50	GO:0030154	cell differentiation
0.50	GO:0071158	positive regulation of cell cycle arrest
0.50	GO:0007095	mitotic G2 DNA damage checkpoint
0.49	GO:0016525	negative regulation of angiogenesis

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.53	GO:0008013	beta-catenin binding
0.48	GO:0019899	enzyme binding
0.47	GO:0008134	transcription factor binding
0.45	GO:0042802	identical protein binding
0.39	GO:0000989	transcription factor activity, transcription factor binding
0.39	GO:1990841	promoter-specific chromatin binding
0.34	GO:0031490	chromatin DNA binding

0.61	GO:0005634	nucleus
0.44	GO:0005829	cytosol
0.43	GO:0070013	intracellular organelle lumen
0.40	GO:0044446	intracellular organelle part
0.32	GO:0005739	mitochondrion
0.32	GO:0043234	protein complex

tr|T1EIE8|T1EIE8_HELRO
Uncharacterized protein
Search

0.10	RING finger protein 38

0.59	GO:0016567	protein ubiquitination
0.54	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.52	GO:0048149	behavioral response to ethanol
0.52	GO:0007616	long-term memory
0.44	GO:0008584	male gonad development
0.40	GO:0007286	spermatid development
0.37	GO:0001578	microtubule bundle formation
0.36	GO:0000910	cytokinesis

0.60	GO:0004842	ubiquitin-protein transferase activity
0.53	GO:0061659	ubiquitin-like protein ligase activity
0.50	GO:0016874	ligase activity
0.38	GO:0005515	protein binding
0.36	GO:0046872	metal ion binding
0.34	GO:0003723	RNA binding

0.53	GO:0005654	nucleoplasm
0.44	GO:0036126	sperm flagellum
0.35	GO:0005856	cytoskeleton
0.30	GO:0031224	intrinsic component of membrane

0.50	EC:6	GO:0016874
0.60	KEGG:R03876	GO:0004842

tr|T1EIE9|T1EIE9_HELRO
Uncharacterized protein
Search

0.47	GO:1903506	regulation of nucleic acid-templated transcription
0.47	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.47	GO:0010468	regulation of gene expression
0.45	GO:0045773	positive regulation of axon extension
0.43	GO:0007411	axon guidance
0.36	GO:0043044	ATP-dependent chromatin remodeling
0.34	GO:1902679	negative regulation of RNA biosynthetic process
0.34	GO:0006397	mRNA processing
0.33	GO:0006351	transcription, DNA-templated

0.53	GO:0003677	DNA binding
0.33	GO:0046872	metal ion binding

0.59	GO:0005634	nucleus
0.35	GO:0000785	chromatin
0.35	GO:0043233	organelle lumen
0.34	GO:1904949	ATPase complex
0.30	GO:0016020	membrane

tr|T1EIF0|T1EIF0_HELRO
Uncharacterized protein
Search

0.74	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.49	GO:0031532	actin cytoskeleton reorganization
0.34	GO:0006508	proteolysis

0.75	GO:0004864	protein phosphatase inhibitor activity
0.71	GO:0003779	actin binding
0.35	GO:0004252	serine-type endopeptidase activity

0.45	GO:0005829	cytosol
0.43	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.35

GO:0004252

tr|T1EIF1|T1EIF1_HELRO
Uncharacterized protein
Search

0.70	transcription factor MafK

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0006351	transcription, DNA-templated
0.45	GO:1902680	positive regulation of RNA biosynthetic process
0.42	GO:0060322	head development
0.37	GO:1902679	negative regulation of RNA biosynthetic process

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.46	GO:0046982	protein heterodimerization activity
0.41	GO:0001067	regulatory region nucleic acid binding
0.35	GO:0042803	protein homodimerization activity
0.33	GO:0004386	helicase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005634	nucleus
0.41	GO:0005667	transcription factor complex
0.36	GO:0031974	membrane-enclosed lumen
0.35	GO:0044446	intracellular organelle part
0.33	GO:0019013	viral nucleocapsid
0.33	GO:0030529	intracellular ribonucleoprotein complex

tr|T1EIF2|T1EIF2_HELRO
Uncharacterized protein
Search

0.33	GO:0000398	mRNA splicing, via spliceosome
0.33	GO:0008610	lipid biosynthetic process
0.32	GO:0055114	oxidation-reduction process

0.59	GO:0003723	RNA binding
0.33	GO:0005506	iron ion binding
0.32	GO:0016491	oxidoreductase activity

0.65	GO:0005686	U2 snRNP
0.30	GO:0044425	membrane part

0.32

GO:0016491

tr|T1EIF3|T1EIF3_HELRO
Cytidine deaminase
Search

0.48	Cytidine/deoxycytidine deaminase

0.80	GO:0009972	cytidine deamination
0.37	GO:0006217	deoxycytidine catabolic process
0.35	GO:0008655	pyrimidine-containing compound salvage
0.35	GO:0009264	deoxyribonucleotide catabolic process
0.34	GO:0016311	dephosphorylation

0.80	GO:0004126	cytidine deaminase activity
0.63	GO:0008270	zinc ion binding
0.35	GO:0008253	5'-nucleotidase activity
0.34	GO:0042802	identical protein binding
0.33	GO:0048037	cofactor binding

0.38	GO:0005829	cytosol
0.34	GO:0005634	nucleus

0.80

EC:3.5.4.5

GO:0004126

tr|T1EIF4|T1EIF4_HELRO
Uncharacterized protein
Search

tr|T1EIF5|T1EIF5_HELRO
Uncharacterized protein
Search

0.72	GO:0045892	negative regulation of transcription, DNA-templated
0.47	GO:0060575	intestinal epithelial cell differentiation
0.46	GO:0010976	positive regulation of neuron projection development
0.46	GO:0045746	negative regulation of Notch signaling pathway
0.42	GO:0006357	regulation of transcription by RNA polymerase II
0.37	GO:0045820	negative regulation of glycolytic process
0.37	GO:1903715	regulation of aerobic respiration
0.37	GO:0030851	granulocyte differentiation
0.36	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.36	GO:0001666	response to hypoxia

0.81	GO:0003714	transcription corepressor activity
0.59	GO:0003700	DNA binding transcription factor activity
0.33	GO:0003682	chromatin binding
0.33	GO:0005515	protein binding
0.33	GO:0046872	metal ion binding
0.32	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.32	GO:0020037	heme binding

0.42	GO:0005634	nucleus
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016705

tr|T1EIF6|T1EIF6_HELRO
Uncharacterized protein
Search

0.45	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.36	GO:0000398	mRNA splicing, via spliceosome
0.33	GO:0006357	regulation of transcription by RNA polymerase II
0.32	GO:0055085	transmembrane transport

0.67	GO:0004386	helicase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0003676	nucleic acid binding
0.41	GO:0140098	catalytic activity, acting on RNA
0.39	GO:0008186	RNA-dependent ATPase activity
0.36	GO:0042802	identical protein binding
0.33	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.32	GO:0008270	zinc ion binding

0.43	GO:0005730	nucleolus
0.43	GO:0032040	small-subunit processome
0.36	GO:0005681	spliceosomal complex
0.34	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

tr|T1EIF7|T1EIF7_HELRO
Uncharacterized protein
Search

0.75	GO:0032456	endocytic recycling
0.45	GO:0008154	actin polymerization or depolymerization
0.44	GO:1903955	positive regulation of protein targeting to mitochondrion
0.43	GO:0070830	bicellular tight junction assembly
0.43	GO:0034446	substrate adhesion-dependent cell spreading
0.41	GO:0031175	neuron projection development
0.41	GO:0071822	protein complex subunit organization
0.41	GO:0031532	actin cytoskeleton reorganization
0.39	GO:0034622	cellular macromolecular complex assembly
0.39	GO:0070271	protein complex biogenesis

0.72	GO:0017137	Rab GTPase binding
0.51	GO:0046872	metal ion binding
0.49	GO:0071949	FAD binding
0.44	GO:0031005	filamin binding
0.43	GO:0003779	actin binding
0.42	GO:0042805	actinin binding
0.40	GO:0032403	protein complex binding
0.34	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
0.33	GO:0070300	phosphatidic acid binding
0.33	GO:0003677	DNA binding

0.43	GO:0097517	contractile actin filament bundle
0.43	GO:0042641	actomyosin
0.42	GO:0055037	recycling endosome
0.42	GO:0005923	bicellular tight junction
0.38	GO:0005829	cytosol
0.38	GO:0005654	nucleoplasm
0.38	GO:0005886	plasma membrane
0.35	GO:0042995	cell projection
0.35	GO:0030496	midbody
0.35	GO:0097458	neuron part

0.34

EC:1.14.13

GO:0016709

tr|T1EIF8|T1EIF8_HELRO
Uncharacterized protein
Search

RGS8

0.72	Regulator of G-protein signaling 8

0.76	GO:0043547	positive regulation of GTPase activity
0.71	GO:0007186	G-protein coupled receptor signaling pathway

0.76

GO:0005096

GTPase activator activity

tr|T1EIF9|T1EIF9_HELRO
Uncharacterized protein
Search

0.76	GO:0016579	protein deubiquitination
0.71	GO:0006511	ubiquitin-dependent protein catabolic process
0.34	GO:0016570	histone modification

0.77	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.43	GO:0005509	calcium ion binding
0.34	GO:0008270	zinc ion binding

0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.77

GO:0036459

tr|T1EIG0|T1EIG0_HELRO
Uncharacterized protein
Search

0.58	Cyclin-dependent kinase 5 activator

0.80	GO:0071902	positive regulation of protein serine/threonine kinase activity
0.46	GO:0016310	phosphorylation
0.45	GO:0035011	melanotic encapsulation of foreign target
0.44	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
0.44	GO:0008045	motor neuron axon guidance
0.44	GO:0008340	determination of adult lifespan
0.44	GO:0008344	adult locomotory behavior
0.35	GO:0021722	superior olivary nucleus maturation
0.35	GO:1904809	regulation of dense core granule transport
0.35	GO:0021819	layer formation in cerebral cortex

0.86	GO:0016534	cyclin-dependent protein kinase 5 activator activity
0.48	GO:0016301	kinase activity
0.34	GO:0019901	protein kinase binding
0.33	GO:0030246	carbohydrate binding

0.86	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex
0.44	GO:0030426	growth cone
0.43	GO:0030425	dendrite
0.43	GO:0030424	axon
0.43	GO:0043025	neuronal cell body
0.34	GO:0005622	intracellular
0.33	GO:0045202	synapse
0.33	GO:0043233	organelle lumen
0.32	GO:0043227	membrane-bounded organelle
0.30	GO:0016020	membrane

tr|T1EIG1|T1EIG1_HELRO
Uncharacterized protein
Search

0.59	GO:0006030	chitin metabolic process
0.56	GO:0006898	receptor-mediated endocytosis
0.42	GO:0055114	oxidation-reduction process

0.61	GO:0005044	scavenger receptor activity
0.58	GO:0008061	chitin binding

0.52	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

tr|T1EIG2|T1EIG2_HELRO
Uncharacterized protein
Search

tr|T1EIG3|T1EIG3_HELRO
Uncharacterized protein
Search

tr|T1EIG4|T1EIG4_HELRO
Uncharacterized protein
Search

TMEM18

0.74	Transmembrane protein 18

0.51	GO:0016477	cell migration
0.39	GO:0097659	nucleic acid-templated transcription
0.37	GO:0010467	gene expression
0.37	GO:0034645	cellular macromolecule biosynthetic process

0.38

GO:0003677

DNA binding

0.52	GO:0031965	nuclear membrane
0.36	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

tr|T1EIG5|T1EIG5_HELRO
Uncharacterized protein
Search

0.10	HMG-CoA synthase (inferred by orthology to a S. mansoni protein)

0.60	GO:0046907	intracellular transport
0.59	GO:0034613	cellular protein localization
0.57	GO:0015031	protein transport
0.50	GO:0006887	exocytosis
0.42	GO:0097480	establishment of synaptic vesicle localization
0.42	GO:0099504	synaptic vesicle cycle
0.42	GO:0099003	vesicle-mediated transport in synapse
0.42	GO:0099643	signal release from synapse
0.42	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.41	GO:0032224	positive regulation of synaptic transmission, cholinergic

0.71	GO:0017137	Rab GTPase binding
0.48	GO:0046872	metal ion binding
0.39	GO:0008022	protein C-terminus binding
0.37	GO:0008289	lipid binding
0.33	GO:0016301	kinase activity
0.33	GO:0043168	anion binding

0.51	GO:0048786	presynaptic active zone
0.41	GO:0005622	intracellular
0.39	GO:0030424	axon
0.34	GO:0030054	cell junction
0.30	GO:0016020	membrane

tr|T1EIG6|T1EIG6_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.48	GO:0007399	nervous system development
0.44	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
0.43	GO:0120036	plasma membrane bounded cell projection organization
0.43	GO:0030154	cell differentiation
0.43	GO:0009653	anatomical structure morphogenesis
0.43	GO:0007423	sensory organ development
0.42	GO:0007267	cell-cell signaling
0.41	GO:0035159	regulation of tube length, open tracheal system
0.41	GO:0007389	pattern specification process

0.70	GO:0005509	calcium ion binding
0.39	GO:0050839	cell adhesion molecule binding
0.35	GO:0004022	alcohol dehydrogenase (NAD) activity
0.35	GO:0015322	secondary active oligopeptide transmembrane transporter activity
0.35	GO:0005057	signal transducer activity, downstream of receptor
0.35	GO:0004872	receptor activity
0.34	GO:0032403	protein complex binding
0.34	GO:0005102	receptor binding
0.33	GO:0003723	RNA binding

0.55	GO:0005886	plasma membrane
0.37	GO:0030054	cell junction
0.37	GO:0045177	apical part of cell
0.35	GO:0032391	photoreceptor connecting cilium
0.34	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0043231	intracellular membrane-bounded organelle
0.34	GO:0009986	cell surface
0.30	GO:0016021	integral component of membrane

0.35

EC:1.1.1.1

GO:0004022

tr|T1EIG7|T1EIG7_HELRO
Uncharacterized protein
Search

tr|T1EIG8|T1EIG8_HELRO
Uncharacterized protein
Search

0.85	GO:0043551	regulation of phosphatidylinositol 3-kinase activity
0.58	GO:2001275	positive regulation of glucose import in response to insulin stimulus
0.51	GO:0016310	phosphorylation
0.47	GO:0007165	signal transduction
0.46	GO:0032869	cellular response to insulin stimulus
0.42	GO:0046488	phosphatidylinositol metabolic process
0.42	GO:0030258	lipid modification
0.35	GO:0040008	regulation of growth
0.34	GO:0016567	protein ubiquitination
0.33	GO:0046474	glycerophospholipid biosynthetic process

0.85	GO:0035014	phosphatidylinositol 3-kinase regulator activity
0.52	GO:0016301	kinase activity
0.40	GO:0001784	phosphotyrosine residue binding
0.35	GO:0046872	metal ion binding
0.33	GO:0016773	phosphotransferase activity, alcohol group as acceptor

0.83	GO:0005942	phosphatidylinositol 3-kinase complex
0.34	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

0.33

GO:0016773

tr|T1EIG9|T1EIG9_HELRO
Uncharacterized protein
Search

0.43	GO:1903506	regulation of nucleic acid-templated transcription
0.43	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.42	GO:0010468	regulation of gene expression
0.38	GO:0006351	transcription, DNA-templated
0.32	GO:0032259	methylation
0.32	GO:0006508	proteolysis

0.51	GO:0003676	nucleic acid binding
0.43	GO:0046872	metal ion binding
0.41	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.32	GO:0004222	metalloendopeptidase activity
0.32	GO:0005515	protein binding
0.32	GO:0008168	methyltransferase activity

0.41	GO:0005634	nucleus
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0005829	cytosol
0.33	GO:0044446	intracellular organelle part
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0004222

tr|T1EIH0|T1EIH0_HELRO
Uncharacterized protein
Search

0.59

GO:0003723

RNA binding

tr|T1EIH1|T1EIH1_HELRO
Uncharacterized protein
Search

0.10	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

0.62	GO:0071805	potassium ion transmembrane transport
0.56	GO:0043269	regulation of ion transport
0.56	GO:0034762	regulation of transmembrane transport
0.47	GO:0016057	regulation of membrane potential in photoreceptor cell
0.47	GO:0007637	proboscis extension reflex
0.47	GO:0071632	optomotor response
0.47	GO:0050802	circadian sleep/wake cycle, sleep
0.46	GO:0071484	cellular response to light intensity
0.46	GO:0045938	positive regulation of circadian sleep/wake cycle, sleep
0.46	GO:0050433	regulation of catecholamine secretion

0.69	GO:0005216	ion channel activity
0.63	GO:0022832	voltage-gated channel activity
0.62	GO:0015079	potassium ion transmembrane transporter activity

0.35

GO:0005887

integral component of plasma membrane

tr|T1EIH2|T1EIH2_HELRO
Uncharacterized protein
Search

tr|T1EIH3|T1EIH3_HELRO
Uncharacterized protein
Search

0.47	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
0.44	GO:0007528	neuromuscular junction development
0.43	GO:0030198	extracellular matrix organization
0.40	GO:0048731	system development
0.39	GO:0071230	cellular response to amino acid stimulus
0.38	GO:0009653	anatomical structure morphogenesis
0.38	GO:0007155	cell adhesion
0.38	GO:0009888	tissue development
0.37	GO:0030154	cell differentiation
0.37	GO:0052547	regulation of peptidase activity

0.72	GO:0005201	extracellular matrix structural constituent
0.38	GO:0042302	structural constituent of cuticle
0.38	GO:0048407	platelet-derived growth factor binding
0.37	GO:0030414	peptidase inhibitor activity
0.35	GO:0008201	heparin binding
0.35	GO:0061135	endopeptidase regulator activity
0.34	GO:0005178	integrin binding
0.34	GO:0005044	scavenger receptor activity
0.33	GO:0046332	SMAD binding
0.33	GO:0002020	protease binding

0.75	GO:0005581	collagen trimer
0.70	GO:0044420	extracellular matrix component
0.66	GO:0005578	proteinaceous extracellular matrix
0.44	GO:0099081	supramolecular polymer
0.43	GO:0031594	neuromuscular junction
0.37	GO:0005615	extracellular space
0.34	GO:0005788	endoplasmic reticulum lumen
0.30	GO:0016020	membrane

0.32

GO:0016787

tr|T1EIH4|T1EIH4_HELRO
Uncharacterized protein
Search

0.10	polyadenylate-binding protein 1-like

0.70	GO:1904247	positive regulation of polynucleotide adenylyltransferase activity
0.40	GO:0042981	regulation of apoptotic process
0.40	GO:0071222	cellular response to lipopolysaccharide
0.40	GO:0006915	apoptotic process
0.40	GO:0016973	poly(A)+ mRNA export from nucleus
0.39	GO:0000165	MAPK cascade
0.38	GO:0043069	negative regulation of programmed cell death
0.35	GO:0006397	mRNA processing
0.35	GO:0038034	signal transduction in absence of ligand
0.35	GO:0031123	RNA 3'-end processing

0.59	GO:0003723	RNA binding
0.39	GO:0005515	protein binding
0.33	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

0.41	GO:0042405	nuclear inclusion body
0.40	GO:0097136	Bcl-2 family protein complex
0.38	GO:0016607	nuclear speck
0.36	GO:0030529	intracellular ribonucleoprotein complex
0.35	GO:0098805	whole membrane
0.35	GO:0098588	bounding membrane of organelle
0.34	GO:0044437	vacuolar part
0.33	GO:0005829	cytosol
0.33	GO:0019867	outer membrane
0.33	GO:0031966	mitochondrial membrane

0.33

EC:1.4.1

GO:0016639

tr|T1EIH6|T1EIH6_HELRO
Uncharacterized protein
Search

tr|T1EIH7|T1EIH7_HELRO
Uncharacterized protein
Search

0.34	PDZ/DHR/GLGF domain protein

0.59

GO:0006886

intracellular protein transport

0.68	GO:0017137	Rab GTPase binding
0.48	GO:0046872	metal ion binding

0.41	GO:0005622	intracellular
0.30	GO:0016020	membrane

tr|T1EIH8|T1EIH8_HELRO
Uncharacterized protein
Search

0.11

Tenascin

0.74	GO:0001525	angiogenesis
0.71	GO:0043066	negative regulation of apoptotic process
0.53	GO:0051005	negative regulation of lipoprotein lipase activity
0.51	GO:0070328	triglyceride homeostasis
0.50	GO:2000351	regulation of endothelial cell apoptotic process
0.48	GO:0007596	blood coagulation
0.43	GO:0007155	cell adhesion
0.43	GO:0019216	regulation of lipid metabolic process
0.41	GO:0001666	response to hypoxia
0.40	GO:0051260	protein homooligomerization

0.48	GO:0004857	enzyme inhibitor activity
0.45	GO:0042802	identical protein binding
0.40	GO:0005509	calcium ion binding
0.39	GO:0005178	integrin binding
0.38	GO:0042302	structural constituent of cuticle
0.38	GO:0008083	growth factor activity
0.36	GO:0030674	protein binding, bridging
0.35	GO:0003723	RNA binding

0.68	GO:0005615	extracellular space
0.39	GO:0005578	proteinaceous extracellular matrix
0.38	GO:0005769	early endosome
0.37	GO:0009986	cell surface
0.37	GO:0005794	Golgi apparatus
0.34	GO:0043234	protein complex
0.30	GO:0016020	membrane

tr|T1EIH9|T1EIH9_HELRO
Uncharacterized protein
Search

0.44	GO:1903506	regulation of nucleic acid-templated transcription
0.44	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.43	GO:0010468	regulation of gene expression
0.38	GO:1902679	negative regulation of RNA biosynthetic process
0.38	GO:0070895	negative regulation of transposon integration
0.36	GO:0001658	branching involved in ureteric bud morphogenesis
0.35	GO:0040034	regulation of development, heterochronic
0.35	GO:0006351	transcription, DNA-templated
0.34	GO:0034224	cellular response to zinc ion starvation
0.33	GO:1902680	positive regulation of RNA biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.42	GO:0046872	metal ion binding
0.38	GO:0003700	DNA binding transcription factor activity
0.36	GO:0030674	protein binding, bridging

0.39	GO:0005634	nucleus
0.34	GO:0043233	organelle lumen
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

tr|T1EII0|T1EII0_HELRO
Uncharacterized protein
Search

0.63	GO:0009301	snRNA transcription
0.59	GO:0033566	gamma-tubulin complex localization
0.56	GO:0006366	transcription by RNA polymerase II
0.47	GO:0006364	rRNA processing

0.44

GO:0003677

DNA binding

0.59	GO:0008274	gamma-tubulin ring complex
0.58	GO:0016604	nuclear body
0.55	GO:0005730	nucleolus
0.54	GO:0030688	preribosome, small subunit precursor

tr|T1EII1|T1EII1_HELRO
Uncharacterized protein
Search

0.10	EH domain-binding protein 1

0.64	GO:0045035	sensory organ precursor cell division
0.60	GO:0110010	basolateral protein secretion
0.60	GO:0045747	positive regulation of Notch signaling pathway
0.59	GO:0061864	basement membrane constituent secretion
0.58	GO:0110011	regulation of basement membrane organization
0.56	GO:0032456	endocytic recycling
0.39	GO:0035335	peptidyl-tyrosine dephosphorylation
0.38	GO:0006897	endocytosis

0.54	GO:0017137	Rab GTPase binding
0.44	GO:0003779	actin binding
0.39	GO:0004725	protein tyrosine phosphatase activity
0.39	GO:0046872	metal ion binding

0.60	GO:0031941	filamentous actin
0.56	GO:0005829	cytosol
0.54	GO:0005938	cell cortex
0.48	GO:0005886	plasma membrane
0.39	GO:0005768	endosome

0.39

GO:0004725

tr|T1EII2|T1EII2_HELRO
Uncharacterized protein
Search

0.11

Tenascin

0.74	GO:0001525	angiogenesis
0.71	GO:0043066	negative regulation of apoptotic process
0.52	GO:0051005	negative regulation of lipoprotein lipase activity
0.50	GO:2000351	regulation of endothelial cell apoptotic process
0.50	GO:0070328	triglyceride homeostasis
0.47	GO:0007596	blood coagulation
0.43	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.41	GO:0006461	protein complex assembly
0.41	GO:0001666	response to hypoxia
0.41	GO:0001775	cell activation

0.47	GO:0004857	enzyme inhibitor activity
0.45	GO:0042802	identical protein binding
0.41	GO:0030674	protein binding, bridging
0.41	GO:0005509	calcium ion binding
0.39	GO:0005102	receptor binding
0.38	GO:0001104	RNA polymerase II transcription cofactor activity
0.35	GO:0003723	RNA binding

0.68	GO:0005615	extracellular space
0.39	GO:0005578	proteinaceous extracellular matrix
0.38	GO:0043234	protein complex
0.37	GO:0044451	nucleoplasm part
0.30	GO:0016020	membrane

tr|T1EII3|T1EII3_HELRO
Uncharacterized protein
Search

0.41	GO:0052548	regulation of endopeptidase activity
0.41	GO:0010466	negative regulation of peptidase activity
0.40	GO:0035987	endodermal cell differentiation
0.39	GO:0030198	extracellular matrix organization
0.38	GO:0048513	animal organ development
0.38	GO:0007160	cell-matrix adhesion
0.37	GO:0072001	renal system development
0.36	GO:0071230	cellular response to amino acid stimulus
0.36	GO:1903225	negative regulation of endodermal cell differentiation
0.36	GO:0006030	chitin metabolic process

0.54	GO:0005201	extracellular matrix structural constituent
0.41	GO:0004867	serine-type endopeptidase inhibitor activity
0.40	GO:0042302	structural constituent of cuticle
0.38	GO:0042802	identical protein binding
0.38	GO:0008201	heparin binding
0.36	GO:0008061	chitin binding
0.35	GO:0046332	SMAD binding
0.34	GO:0005044	scavenger receptor activity
0.34	GO:0048407	platelet-derived growth factor binding
0.34	GO:0032403	protein complex binding

0.57	GO:0005581	collagen trimer
0.52	GO:0044420	extracellular matrix component
0.50	GO:0005578	proteinaceous extracellular matrix
0.39	GO:0099081	supramolecular polymer
0.36	GO:0005615	extracellular space
0.34	GO:0005788	endoplasmic reticulum lumen
0.33	GO:1903561	extracellular vesicle
0.32	GO:0030127	COPII vesicle coat
0.30	GO:0016021	integral component of membrane

0.33

GO:0008234

tr|T1EII4|T1EII4_HELRO
Uncharacterized protein
Search

0.71	GO:0035335	peptidyl-tyrosine dephosphorylation
0.61	GO:0034164	negative regulation of toll-like receptor 9 signaling pathway
0.61	GO:0032687	negative regulation of interferon-alpha production
0.59	GO:0032688	negative regulation of interferon-beta production
0.59	GO:0048671	negative regulation of collateral sprouting
0.59	GO:0090557	establishment of endothelial intestinal barrier
0.59	GO:0061000	negative regulation of dendritic spine development
0.58	GO:0022038	corpus callosum development
0.58	GO:0048681	negative regulation of axon regeneration
0.57	GO:0030517	negative regulation of axon extension

0.72	GO:0004725	protein tyrosine phosphatase activity
0.59	GO:0035374	chondroitin sulfate binding
0.55	GO:0008201	heparin binding
0.43	GO:0043395	heparan sulfate proteoglycan binding
0.39	GO:0004896	cytokine receptor activity

0.44	GO:0099061	integral component of postsynaptic density membrane
0.43	GO:0030285	integral component of synaptic vesicle membrane
0.42	GO:0043204	perikaryon
0.41	GO:0030424	axon
0.40	GO:0030054	cell junction
0.39	GO:0070062	extracellular exosome

0.72

GO:0004725

tr|T1EII5|T1EII5_HELRO
Uncharacterized protein
Search

0.76	GO:0006338	chromatin remodeling
0.33	GO:2001141	regulation of RNA biosynthetic process
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression

0.55

GO:0003677

DNA binding

0.75

GO:0070603

SWI/SNF superfamily-type complex

tr|T1EII6|T1EII6_HELRO
Uncharacterized protein
Search

0.68	GO:0016573	histone acetylation
0.53	GO:1903506	regulation of nucleic acid-templated transcription
0.53	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:0010468	regulation of gene expression
0.38	GO:0010030	positive regulation of seed germination
0.36	GO:1902680	positive regulation of RNA biosynthetic process
0.34	GO:0006338	chromatin remodeling
0.33	GO:0007010	cytoskeleton organization
0.32	GO:0008360	regulation of cell shape

0.69	GO:0004402	histone acetyltransferase activity
0.65	GO:0003712	transcription cofactor activity
0.55	GO:0008270	zinc ion binding

0.57	GO:0005634	nucleus
0.49	GO:0031248	protein acetyltransferase complex
0.46	GO:0031974	membrane-enclosed lumen
0.42	GO:0044446	intracellular organelle part
0.34	GO:0000428	DNA-directed RNA polymerase complex
0.34	GO:0005667	transcription factor complex
0.33	GO:0005694	chromosome
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0004402

tr|T1EII7|T1EII7_HELRO
Uncharacterized protein
Search

tr|T1EII8|T1EII8_HELRO
Uncharacterized protein
Search

tr|T1EII9|T1EII9_HELRO
Uncharacterized protein
Search

tr|T1EIJ0|T1EIJ0_HELRO
Uncharacterized protein
Search

0.76	GO:0006836	neurotransmitter transport
0.55	GO:0055085	transmembrane transport
0.50	GO:0015849	organic acid transport
0.50	GO:0015711	organic anion transport
0.47	GO:0071705	nitrogen compound transport
0.44	GO:0042908	xenobiotic transport
0.42	GO:0072348	sulfur compound transport
0.41	GO:0006812	cation transport
0.36	GO:0015893	drug transport
0.35	GO:0015850	organic hydroxy compound transport

0.79	GO:0005328	neurotransmitter:sodium symporter activity
0.51	GO:0005342	organic acid transmembrane transporter activity
0.51	GO:0008514	organic anion transmembrane transporter activity
0.49	GO:0015296	anion:cation symporter activity
0.45	GO:0015238	drug transmembrane transporter activity
0.44	GO:0042910	xenobiotic transmembrane transporter activity
0.42	GO:1901682	sulfur compound transmembrane transporter activity
0.36	GO:0008504	monoamine transmembrane transporter activity
0.35	GO:0072349	modified amino acid transmembrane transporter activity
0.35	GO:0051184	cofactor transmembrane transporter activity

0.49	GO:0005887	integral component of plasma membrane
0.33	GO:0098793	presynapse
0.33	GO:0043005	neuron projection

tr|T1EIJ1|T1EIJ1_HELRO
Uncharacterized protein
Search

0.66	Tyrosine-protein phosphatase non-receptor type 11 (Fragment)

0.74

GO:0035335

peptidyl-tyrosine dephosphorylation

0.75

GO:0004725

protein tyrosine phosphatase activity

0.42

GO:0005737

cytoplasm

0.75

GO:0004725

tr|T1EIJ2|T1EIJ2_HELRO
Uncharacterized protein
Search

0.76	GO:0035725	sodium ion transmembrane transport
0.73	GO:0034765	regulation of ion transmembrane transport
0.49	GO:0019233	sensory perception of pain

0.83	GO:0005248	voltage-gated sodium channel activity
0.71	GO:0022832	voltage-gated channel activity
0.69	GO:0022839	ion gated channel activity
0.68	GO:0008381	mechanosensitive ion channel activity
0.63	GO:0005509	calcium ion binding

0.82

GO:0001518

voltage-gated sodium channel complex

tr|T1EIJ3|T1EIJ3_HELRO
Uncharacterized protein
Search

tr|T1EIJ4|T1EIJ4_HELRO
Uncharacterized protein
Search

0.58	RNA-directed DNA polymerase from mobile element jockey (Fragment)

0.68	GO:0006278	RNA-dependent DNA biosynthetic process
0.38	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.35	GO:0035335	peptidyl-tyrosine dephosphorylation
0.35	GO:0007018	microtubule-based movement
0.34	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression

0.69	GO:0003964	RNA-directed DNA polymerase activity
0.39	GO:0004519	endonuclease activity
0.36	GO:0004386	helicase activity
0.35	GO:0004725	protein tyrosine phosphatase activity
0.35	GO:0003777	microtubule motor activity
0.35	GO:0008017	microtubule binding
0.35	GO:0003779	actin binding
0.35	GO:0046872	metal ion binding
0.34	GO:0043565	sequence-specific DNA binding
0.34	GO:0004527	exonuclease activity

0.35	GO:0016459	myosin complex
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.69

GO:0003964

tr|T1EIJ5|T1EIJ5_HELRO
Uncharacterized protein
Search

0.86	Serine/threonine-protein kinase par-1 (Fragment)

0.80	GO:0030010	establishment of cell polarity
0.75	GO:0000226	microtubule cytoskeleton organization
0.63	GO:0006468	protein phosphorylation
0.48	GO:0030860	regulation of polarized epithelial cell differentiation
0.48	GO:0030709	border follicle cell delamination
0.48	GO:0007318	pole plasm protein localization
0.47	GO:0035332	positive regulation of hippo signaling
0.47	GO:0001737	establishment of imaginal disc-derived wing hair orientation
0.47	GO:0007317	regulation of pole plasm oskar mRNA localization
0.47	GO:0007294	germarium-derived oocyte fate determination

0.70	GO:0004674	protein serine/threonine kinase activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0008144	drug binding
0.47	GO:0050321	tau-protein kinase activity
0.33	GO:0003676	nucleic acid binding
0.33	GO:0004518	nuclease activity
0.32	GO:0046872	metal ion binding

0.47	GO:0045172	germline ring canal
0.47	GO:0061174	type I terminal bouton
0.47	GO:0045169	fusome
0.46	GO:0031594	neuromuscular junction
0.45	GO:0016323	basolateral plasma membrane
0.44	GO:0005938	cell cortex
0.33	GO:0005829	cytosol
0.33	GO:0005694	chromosome
0.30	GO:0016021	integral component of membrane

0.70

GO:0004674

tr|T1EIJ6|T1EIJ6_HELRO
Uncharacterized protein
Search

0.57	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.37	GO:0023014	signal transduction by protein phosphorylation
0.36	GO:0000160	phosphorelay signal transduction system
0.35	GO:1902680	positive regulation of RNA biosynthetic process
0.34	GO:0018106	peptidyl-histidine phosphorylation
0.33	GO:0071555	cell wall organization

0.67	GO:0046983	protein dimerization activity
0.55	GO:0003700	DNA binding transcription factor activity
0.39	GO:0003677	DNA binding
0.37	GO:0000155	phosphorelay sensor kinase activity
0.34	GO:0071111	cyclic-guanylate-specific phosphodiesterase activity
0.33	GO:0046872	metal ion binding

0.66	GO:0005667	transcription factor complex
0.61	GO:0005634	nucleus
0.45	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.37	EC:2.7.3	GO:0000155
0.34	KEGG:R08991	GO:0071111

tr|T1EIJ7|T1EIJ7_HELRO
Uncharacterized protein
Search

0.57	Nephrocystin-3 (Fragment)

0.84	GO:0060026	convergent extension
0.84	GO:0071909	determination of stomach left/right asymmetry
0.83	GO:0071908	determination of intestine left/right asymmetry
0.83	GO:0003143	embryonic heart tube morphogenesis
0.83	GO:0061371	determination of heart left/right asymmetry
0.80	GO:0048496	maintenance of animal organ identity
0.80	GO:0001822	kidney development
0.79	GO:0035469	determination of pancreatic left/right asymmetry
0.79	GO:0071910	determination of liver left/right asymmetry
0.79	GO:0072189	ureter development

0.39	GO:0003777	microtubule motor activity
0.36	GO:0005515	protein binding

0.71	GO:0097543	ciliary inversin compartment
0.67	GO:0097546	ciliary base
0.40	GO:0005871	kinesin complex
0.37	GO:0005829	cytosol

tr|T1EIJ8|T1EIJ8_HELRO
Uncharacterized protein
Search

0.61	GO:0006508	proteolysis
0.43	GO:0051493	regulation of cytoskeleton organization
0.36	GO:0032501	multicellular organismal process
0.35	GO:0060014	granulosa cell differentiation
0.34	GO:0007165	signal transduction
0.34	GO:0006672	ceramide metabolic process
0.34	GO:0007548	sex differentiation
0.34	GO:0048511	rhythmic process
0.34	GO:0043413	macromolecule glycosylation
0.34	GO:0009101	glycoprotein biosynthetic process

0.82	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.54	GO:0005509	calcium ion binding
0.34	GO:0008378	galactosyltransferase activity
0.34	GO:0004871	signal transducer activity
0.33	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

0.46	GO:0009986	cell surface
0.45	GO:0005622	intracellular
0.36	GO:0005925	focal adhesion
0.35	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.34

GO:0008378

tr|T1EIJ9|T1EIJ9_HELRO
Uncharacterized protein
Search

0.83	Fibroblast growth factor receptor substrate 2 (Fragment)

0.85	GO:0046619	optic placode formation involved in camera-type eye formation
0.85	GO:0060526	prostate glandular acinus morphogenesis
0.84	GO:0060442	branching involved in prostate gland morphogenesis
0.84	GO:2000726	negative regulation of cardiac muscle cell differentiation
0.83	GO:0070307	lens fiber cell development
0.82	GO:0001759	organ induction
0.82	GO:0008543	fibroblast growth factor receptor signaling pathway
0.81	GO:0001702	gastrulation with mouth forming second
0.80	GO:0007405	neuroblast proliferation
0.80	GO:0003281	ventricular septum development

0.85	GO:0005168	neurotrophin TRKA receptor binding
0.85	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
0.83	GO:0005104	fibroblast growth factor receptor binding
0.46	GO:0042802	identical protein binding
0.41	GO:0051082	unfolded protein binding
0.41	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.40	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.39	GO:0016303	1-phosphatidylinositol-3-kinase activity
0.39	GO:0019211	phosphatase activator activity
0.37	GO:0030554	adenyl nucleotide binding

0.77	GO:0005913	cell-cell adherens junction
0.53	GO:0005886	plasma membrane
0.47	GO:0005737	cytoplasm
0.37	GO:0097708	intracellular vesicle
0.36	GO:0012505	endomembrane system
0.30	GO:0016021	integral component of membrane

0.40	EC:2.7.1.153	GO:0046934
0.40	KEGG:R04545	GO:0046934

tr|T1EIK0|T1EIK0_HELRO
Uncharacterized protein
Search

0.59	GO:0006278	RNA-dependent DNA biosynthetic process
0.52	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.60	GO:0003964	RNA-directed DNA polymerase activity
0.53	GO:0004519	endonuclease activity

0.30

GO:0031224

intrinsic component of membrane

0.60

GO:0003964

tr|T1EIK1|T1EIK1_HELRO
Uncharacterized protein
Search

0.70	LIM domain-containing protein jub-like

0.45	GO:0045572	positive regulation of imaginal disc growth
0.44	GO:0035329	hippo signaling
0.44	GO:0071539	protein localization to centrosome
0.43	GO:0030707	ovarian follicle cell development
0.41	GO:0000278	mitotic cell cycle
0.38	GO:0035331	negative regulation of hippo signaling
0.38	GO:2000637	positive regulation of gene silencing by miRNA
0.37	GO:0001666	response to hypoxia
0.36	GO:1903507	negative regulation of nucleic acid-templated transcription
0.35	GO:0007010	cytoskeleton organization

0.54	GO:0046872	metal ion binding
0.37	GO:0003714	transcription corepressor activity
0.34	GO:0003779	actin binding
0.32	GO:0016740	transferase activity

0.44	GO:0045179	apical cortex
0.44	GO:0000242	pericentriolar material
0.43	GO:0005912	adherens junction
0.42	GO:0005911	cell-cell junction
0.37	GO:0000932	P-body
0.36	GO:0005667	transcription factor complex
0.34	GO:0005634	nucleus
0.34	GO:0002102	podosome
0.33	GO:0030055	cell-substrate junction

0.32

GO:0016740

tr|T1EIK2|T1EIK2_HELRO
Uncharacterized protein
Search

0.60	GO:0048513	animal organ development
0.58	GO:0009653	anatomical structure morphogenesis
0.58	GO:0061564	axon development
0.58	GO:0060322	head development
0.57	GO:0007417	central nervous system development
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.52	GO:0007601	visual perception
0.52	GO:0009790	embryo development

0.65	GO:0043565	sequence-specific DNA binding
0.52	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding
0.51	GO:0003700	DNA binding transcription factor activity
0.49	GO:0031490	chromatin DNA binding
0.47	GO:0001012	RNA polymerase II regulatory region DNA binding
0.45	GO:0003690	double-stranded DNA binding
0.32	GO:0046872	metal ion binding

0.61	GO:0005634	nucleus
0.35	GO:0005737	cytoplasm

tr|T1EIK3|T1EIK3_HELRO
Uncharacterized protein
Search

tr|T1EIK4|T1EIK4_HELRO
Uncharacterized protein
Search

0.38	Collagen alpha-1(IX) chain

0.46	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
0.44	GO:0030198	extracellular matrix organization
0.43	GO:0007275	multicellular organism development
0.43	GO:0071495	cellular response to endogenous stimulus
0.42	GO:0071310	cellular response to organic substance
0.42	GO:0009653	anatomical structure morphogenesis
0.42	GO:0071559	response to transforming growth factor beta
0.41	GO:0016525	negative regulation of angiogenesis
0.41	GO:0009888	tissue development
0.41	GO:0030154	cell differentiation

0.72	GO:0005201	extracellular matrix structural constituent
0.43	GO:0042302	structural constituent of cuticle
0.38	GO:0048407	platelet-derived growth factor binding
0.37	GO:0005178	integrin binding
0.37	GO:0004867	serine-type endopeptidase inhibitor activity
0.36	GO:0002020	protease binding
0.36	GO:0046332	SMAD binding
0.33	GO:0042289	MHC class II protein binding
0.33	GO:0008201	heparin binding
0.33	GO:0042802	identical protein binding

0.70	GO:0005581	collagen trimer
0.63	GO:0044420	extracellular matrix component
0.60	GO:0005578	proteinaceous extracellular matrix
0.44	GO:0099081	supramolecular polymer
0.41	GO:0005615	extracellular space
0.37	GO:0031594	neuromuscular junction
0.34	GO:0005783	endoplasmic reticulum
0.33	GO:1903561	extracellular vesicle
0.33	GO:0030054	cell junction
0.32	GO:0070013	intracellular organelle lumen

0.32

GO:0004252

tr|T1EIK5|T1EIK5_HELRO
Uncharacterized protein
Search

0.11	Hemicentin 1 (Fragment)

0.50	GO:0030198	extracellular matrix organization
0.46	GO:0016525	negative regulation of angiogenesis
0.45	GO:0033334	fin morphogenesis
0.44	GO:0006956	complement activation
0.43	GO:0007155	cell adhesion
0.43	GO:0006954	inflammatory response
0.42	GO:0006508	proteolysis
0.42	GO:0038007	netrin-activated signaling pathway
0.41	GO:0007399	nervous system development
0.40	GO:0030154	cell differentiation

0.61	GO:0005509	calcium ion binding
0.46	GO:0008201	heparin binding
0.44	GO:0050840	extracellular matrix binding
0.44	GO:0008237	metallopeptidase activity
0.42	GO:0005042	netrin receptor activity
0.38	GO:0004930	G-protein coupled receptor activity
0.37	GO:0004175	endopeptidase activity
0.36	GO:0017171	serine hydrolase activity
0.36	GO:0008061	chitin binding
0.35	GO:0004096	catalase activity

0.47	GO:0031012	extracellular matrix
0.45	GO:0005579	membrane attack complex
0.42	GO:0005615	extracellular space
0.36	GO:0005938	cell cortex
0.36	GO:0030054	cell junction

0.35

EC:1.11.1.6

GO:0004096

tr|T1EIK6|T1EIK6_HELRO
Uncharacterized protein
Search

0.65	GO:0051693	actin filament capping
0.61	GO:0007010	cytoskeleton organization
0.57	GO:0032456	endocytic recycling
0.42	GO:1903955	positive regulation of protein targeting to mitochondrion
0.41	GO:0070830	bicellular tight junction assembly
0.41	GO:0034446	substrate adhesion-dependent cell spreading
0.41	GO:0031175	neuron projection development
0.39	GO:0051258	protein polymerization
0.39	GO:0097435	supramolecular fiber organization
0.39	GO:0030029	actin filament-based process

0.69	GO:0003779	actin binding
0.65	GO:0005200	structural constituent of cytoskeleton
0.55	GO:0017137	Rab GTPase binding
0.46	GO:0005543	phospholipid binding
0.43	GO:0031005	filamin binding
0.42	GO:0046872	metal ion binding
0.41	GO:0042805	actinin binding
0.39	GO:0032403	protein complex binding
0.36	GO:0002162	dystroglycan binding
0.35	GO:0045296	cadherin binding

0.72	GO:0008091	spectrin
0.42	GO:0055037	recycling endosome
0.41	GO:0097517	contractile actin filament bundle
0.41	GO:0042641	actomyosin
0.40	GO:0005923	bicellular tight junction
0.36	GO:0005886	plasma membrane
0.35	GO:0005770	late endosome
0.35	GO:0010008	endosome membrane
0.35	GO:0120025	plasma membrane bounded cell projection
0.35	GO:0019898	extrinsic component of membrane

0.34

GO:0004725

tr|T1EIK7|T1EIK7_HELRO
Uncharacterized protein
Search

tr|T1EIK8|T1EIK8_HELRO
Uncharacterized protein
Search

0.44	Dynactin subunit 1

0.81	GO:0010970	transport along microtubule
0.45	GO:0099519	dense core granule cytoskeletal transport
0.45	GO:0061670	evoked neurotransmitter secretion
0.44	GO:0016330	second mitotic wave involved in compound eye morphogenesis
0.44	GO:0051256	mitotic spindle midzone assembly
0.44	GO:0035011	melanotic encapsulation of foreign target
0.43	GO:0042052	rhabdomere development
0.43	GO:0099514	synaptic vesicle cytoskeletal transport
0.43	GO:0045198	establishment of epithelial cell apical/basal polarity
0.43	GO:0051299	centrosome separation

0.84	GO:0070840	dynein complex binding
0.43	GO:0045505	dynein intermediate chain binding
0.41	GO:0004386	helicase activity
0.40	GO:0008017	microtubule binding
0.40	GO:0008270	zinc ion binding
0.38	GO:0030554	adenyl nucleotide binding
0.37	GO:0097367	carbohydrate derivative binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0008144	drug binding
0.37	GO:0003676	nucleic acid binding

0.81	GO:0005869	dynactin complex
0.44	GO:0061176	type Ib terminal bouton
0.43	GO:0031616	spindle pole centrosome
0.43	GO:0005818	aster
0.43	GO:1904115	axon cytoplasm
0.42	GO:0005828	kinetochore microtubule
0.42	GO:0030496	midbody
0.41	GO:0000776	kinetochore
0.36	GO:0005740	mitochondrial envelope
0.34	GO:0030286	dynein complex

0.36

EC:1.9.3

GO:0016676

tr|T1EIK9|T1EIK9_HELRO
Uncharacterized protein
Search

0.10	Molecular chaperone DnaJ (Fragment)

0.68	GO:0006457	protein folding
0.59	GO:0009408	response to heat
0.51	GO:0006260	DNA replication
0.41	GO:0060250	germ-line stem-cell niche homeostasis
0.41	GO:0036098	male germ-line stem cell population maintenance
0.41	GO:0090129	positive regulation of synapse maturation
0.41	GO:2001046	positive regulation of integrin-mediated signaling pathway
0.34	GO:0007155	cell adhesion
0.33	GO:0031204	posttranslational protein targeting to membrane, translocation
0.32	GO:0022900	electron transport chain

0.70	GO:0051082	unfolded protein binding
0.61	GO:0031072	heat shock protein binding
0.51	GO:0008270	zinc ion binding
0.46	GO:0032559	adenyl ribonucleotide binding
0.45	GO:0008144	drug binding
0.45	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0005178	integrin binding
0.33	GO:0003676	nucleic acid binding
0.32	GO:0005198	structural molecule activity
0.32	GO:0020037	heme binding

0.42	GO:0005737	cytoplasm
0.40	GO:0031594	neuromuscular junction
0.38	GO:0044421	extracellular region part
0.33	GO:0005581	collagen trimer
0.33	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.32	GO:0031984	organelle subcompartment
0.32	GO:0043231	intracellular membrane-bounded organelle
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1EIL0|T1EIL0_HELRO
Uncharacterized protein
Search

0.48	GO:0007166	cell surface receptor signaling pathway
0.44	GO:0032501	multicellular organismal process
0.44	GO:0007186	G-protein coupled receptor signaling pathway
0.43	GO:0032502	developmental process
0.42	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.41	GO:0050793	regulation of developmental process
0.39	GO:0006508	proteolysis
0.39	GO:0048523	negative regulation of cellular process
0.39	GO:0042060	wound healing
0.38	GO:0052548	regulation of endopeptidase activity

0.67	GO:0005509	calcium ion binding
0.44	GO:0004930	G-protein coupled receptor activity
0.41	GO:0004252	serine-type endopeptidase activity
0.39	GO:0004867	serine-type endopeptidase inhibitor activity
0.38	GO:0005201	extracellular matrix structural constituent
0.38	GO:0008897	holo-[acyl-carrier-protein] synthase activity
0.36	GO:0000287	magnesium ion binding
0.35	GO:0005044	scavenger receptor activity
0.35	GO:0004623	phospholipase A2 activity
0.34	GO:0030246	carbohydrate binding

0.44	GO:0005576	extracellular region
0.39	GO:0005791	rough endoplasmic reticulum
0.35	GO:0005886	plasma membrane
0.34	GO:0043234	protein complex
0.33	GO:0043186	P granule
0.32	GO:0005829	cytosol
0.32	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.41

GO:0004252

tr|T1EIL1|T1EIL1_HELRO
Uncharacterized protein
Search

0.76	GO:0010469	regulation of receptor activity
0.62	GO:0060389	pathway-restricted SMAD protein phosphorylation
0.62	GO:0060298	positive regulation of sarcomere organization
0.62	GO:1903242	regulation of cardiac muscle hypertrophy in response to stress
0.61	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.61	GO:0032924	activin receptor signaling pathway
0.61	GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis
0.61	GO:0055009	atrial cardiac muscle tissue morphogenesis
0.60	GO:0010613	positive regulation of cardiac muscle hypertrophy
0.60	GO:0010596	negative regulation of endothelial cell migration

0.78	GO:0008083	growth factor activity
0.62	GO:0031433	telethonin binding
0.60	GO:0033612	receptor serine/threonine kinase binding
0.55	GO:0005179	hormone activity
0.49	GO:0005160	transforming growth factor beta receptor binding
0.47	GO:0005125	cytokine activity
0.35	GO:0005501	retinoid binding
0.33	GO:0008236	serine-type peptidase activity

0.66	GO:0005576	extracellular region
0.58	GO:0030018	Z disc
0.53	GO:0009986	cell surface
0.30	GO:0016020	membrane

tr|T1EIL2|T1EIL2_HELRO
Uncharacterized protein
Search

0.62	GO:0018108	peptidyl-tyrosine phosphorylation
0.58	GO:0043137	DNA replication, removal of RNA primer
0.52	GO:0006284	base-excision repair
0.48	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.45	GO:0048856	anatomical structure development
0.43	GO:0032501	multicellular organismal process
0.39	GO:0060071	Wnt signaling pathway, planar cell polarity pathway
0.38	GO:0035023	regulation of Rho protein signal transduction
0.36	GO:0065009	regulation of molecular function
0.35	GO:0006351	transcription, DNA-templated

0.62	GO:0004713	protein tyrosine kinase activity
0.57	GO:0017108	5'-flap endonuclease activity
0.54	GO:0008409	5'-3' exonuclease activity
0.50	GO:0032559	adenyl ribonucleotide binding
0.49	GO:0008144	drug binding
0.49	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0000287	magnesium ion binding
0.44	GO:0003677	DNA binding
0.42	GO:0005509	calcium ion binding
0.39	GO:1904929	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway

0.52	GO:0005730	nucleolus
0.51	GO:0005654	nucleoplasm
0.46	GO:0005739	mitochondrion
0.36	GO:0005887	integral component of plasma membrane

0.62

GO:0004713

tr|T1EIL3|T1EIL3_HELRO
Uncharacterized protein
Search

0.70	GO:0043401	steroid hormone mediated signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.47	GO:0030522	intracellular receptor signaling pathway
0.36	GO:0061066	positive regulation of dauer larval development
0.36	GO:0070781	response to biotin
0.36	GO:0043051	regulation of pharyngeal pumping
0.36	GO:0043327	chemotaxis to cAMP

0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.60	GO:0003707	steroid hormone receptor activity
0.33	GO:0005515	protein binding
0.32	GO:0004672	protein kinase activity

0.61	GO:0005634	nucleus
0.33	GO:0005615	extracellular space
0.32	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

tr|T1EIL4|T1EIL4_HELRO
Uncharacterized protein
Search

0.61	GO:0006508	proteolysis
0.52	GO:0007229	integrin-mediated signaling pathway
0.44	GO:0009405	pathogenesis
0.36	GO:0006281	DNA repair
0.33	GO:0019427	acetyl-CoA biosynthetic process from acetate
0.32	GO:0009116	nucleoside metabolic process

0.70	GO:0004222	metalloendopeptidase activity
0.53	GO:0046872	metal ion binding
0.46	GO:0090729	toxin activity
0.38	GO:0003684	damaged DNA binding
0.34	GO:0017124	SH3 domain binding
0.33	GO:0016208	AMP binding
0.33	GO:0003987	acetate-CoA ligase activity
0.32	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

0.35	GO:0005576	extracellular region
0.33	GO:0005794	Golgi apparatus
0.32	GO:0005739	mitochondrion
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.70

GO:0004222

tr|T1EIL5|T1EIL5_HELRO
Uncharacterized protein
Search

0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.53	GO:0035295	tube development
0.52	GO:0030182	neuron differentiation
0.51	GO:0048513	animal organ development
0.51	GO:0048468	cell development
0.50	GO:0051254	positive regulation of RNA metabolic process
0.50	GO:0021778	oligodendrocyte cell fate specification
0.50	GO:0010557	positive regulation of macromolecule biosynthetic process

0.63	GO:0043565	sequence-specific DNA binding
0.51	GO:0044212	transcription regulatory region DNA binding
0.50	GO:0003690	double-stranded DNA binding
0.48	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.47	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.46	GO:0003713	transcription coactivator activity
0.45	GO:0003682	chromatin binding
0.44	GO:0008134	transcription factor binding
0.35	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.34	GO:0004000	adenosine deaminase activity

0.61	GO:0005634	nucleus
0.34	GO:0070013	intracellular organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.34

GO:0004000

tr|T1EIL6|T1EIL6_HELRO
Uncharacterized protein
Search

tr|T1EIL7|T1EIL7_HELRO
Uncharacterized protein
Search

0.11	Posterior sex combs (Fragment)

0.52	GO:0016567	protein ubiquitination
0.48	GO:0033151	V(D)J recombination
0.43	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.42	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.39	GO:0006281	DNA repair
0.37	GO:0006351	transcription, DNA-templated
0.37	GO:0006355	regulation of transcription, DNA-templated

0.51	GO:0061630	ubiquitin protein ligase activity
0.49	GO:0046872	metal ion binding
0.47	GO:0042803	protein homodimerization activity
0.43	GO:0004519	endonuclease activity
0.43	GO:0043565	sequence-specific DNA binding
0.39	GO:0032559	adenyl ribonucleotide binding
0.39	GO:0008144	drug binding
0.39	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0003700	DNA binding transcription factor activity

0.44	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EIL8|T1EIL8_HELRO
Uncharacterized protein
Search

0.80	Zinc metalloproteinase/disintegrin (Fragment)

0.61	GO:0006508	proteolysis
0.54	GO:0007229	integrin-mediated signaling pathway
0.45	GO:0009405	pathogenesis
0.35	GO:0010952	positive regulation of peptidase activity
0.35	GO:0019953	sexual reproduction
0.34	GO:1990830	cellular response to leukemia inhibitory factor
0.34	GO:0042244	spore wall assembly
0.34	GO:0071940	fungal-type cell wall assembly
0.34	GO:0022413	reproductive process in single-celled organism
0.34	GO:0006281	DNA repair

0.70	GO:0004222	metalloendopeptidase activity
0.52	GO:0046872	metal ion binding
0.47	GO:0090729	toxin activity
0.36	GO:0016504	peptidase activator activity
0.34	GO:0003684	damaged DNA binding
0.33	GO:0004749	ribose phosphate diphosphokinase activity
0.33	GO:0016491	oxidoreductase activity

0.35	GO:0005576	extracellular region
0.34	GO:0005619	ascospore wall
0.33	GO:0005739	mitochondrion
0.33	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.70	EC:3.4.24	GO:0004222
0.33	KEGG:R01049	GO:0004749

tr|T1EIL9|T1EIL9_HELRO
Uncharacterized protein
Search

0.77	GO:0043401	steroid hormone mediated signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.44	GO:1902680	positive regulation of RNA biosynthetic process
0.43	GO:1902679	negative regulation of RNA biosynthetic process
0.39	GO:1900078	positive regulation of cellular response to insulin stimulus
0.38	GO:0032355	response to estradiol
0.38	GO:0045670	regulation of osteoclast differentiation

0.78	GO:0003707	steroid hormone receptor activity
0.74	GO:0005496	steroid binding
0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.46	GO:0019904	protein domain specific binding
0.45	GO:0001012	RNA polymerase II regulatory region DNA binding
0.43	GO:0003690	double-stranded DNA binding
0.32	GO:0016491	oxidoreductase activity

0.61	GO:0005634	nucleus
0.50	GO:0045171	intercellular bridge
0.45	GO:0015630	microtubule cytoskeleton
0.43	GO:0043233	organelle lumen
0.40	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.32

GO:0016491

tr|T1EIM0|T1EIM0_HELRO
Uncharacterized protein
Search

0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.54	GO:0006351	transcription, DNA-templated
0.41	GO:0048193	Golgi vesicle transport
0.37	GO:1902679	negative regulation of RNA biosynthetic process
0.37	GO:0007275	multicellular organism development
0.35	GO:0030713	ovarian follicle cell stalk formation
0.35	GO:0060572	morphogenesis of an epithelial bud
0.35	GO:0048859	formation of anatomical boundary

0.62	GO:0043565	sequence-specific DNA binding
0.38	GO:0001012	RNA polymerase II regulatory region DNA binding
0.37	GO:0003690	double-stranded DNA binding

0.59	GO:0005634	nucleus
0.41	GO:0000139	Golgi membrane
0.39	GO:0031301	integral component of organelle membrane
0.34	GO:0031974	membrane-enclosed lumen
0.34	GO:0000428	DNA-directed RNA polymerase complex
0.34	GO:0005667	transcription factor complex
0.34	GO:0000793	condensed chromosome
0.33	GO:0044427	chromosomal part

tr|T1EIM1|T1EIM1_HELRO
Uncharacterized protein
Search

PIK3R1

0.68	Phosphatidylinositol 3-kinase regulatory subunit alpha (Fragment)

0.84	GO:0043551	regulation of phosphatidylinositol 3-kinase activity
0.57	GO:1900076	regulation of cellular response to insulin stimulus
0.56	GO:0051531	NFAT protein import into nucleus
0.56	GO:0007165	signal transduction
0.55	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response
0.55	GO:0046326	positive regulation of glucose import
0.54	GO:0032869	cellular response to insulin stimulus
0.54	GO:0033120	positive regulation of RNA splicing
0.54	GO:0045671	negative regulation of osteoclast differentiation
0.54	GO:0042993	positive regulation of transcription factor import into nucleus

0.85	GO:0035014	phosphatidylinositol 3-kinase regulator activity
0.56	GO:0043125	ErbB-3 class receptor binding
0.56	GO:0043559	insulin binding
0.56	GO:0005168	neurotrophin TRKA receptor binding
0.55	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding
0.54	GO:0005159	insulin-like growth factor receptor binding
0.54	GO:0043560	insulin receptor substrate binding
0.54	GO:0005158	insulin receptor binding
0.53	GO:0001784	phosphotyrosine residue binding
0.52	GO:0016301	kinase activity

0.82	GO:0005942	phosphatidylinositol 3-kinase complex
0.56	GO:1990578	perinuclear endoplasmic reticulum membrane
0.51	GO:0005801	cis-Golgi network
0.49	GO:0005911	cell-cell junction
0.46	GO:0005829	cytosol
0.43	GO:0005634	nucleus
0.42	GO:0043234	protein complex
0.34	GO:0043005	neuron projection
0.32	GO:0005886	plasma membrane

0.36

GO:0016773

tr|T1EIM2|T1EIM2_HELRO
Uncharacterized protein
Search

0.70	GO:0043401	steroid hormone mediated signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.47	GO:0030522	intracellular receptor signaling pathway
0.36	GO:0061066	positive regulation of dauer larval development
0.36	GO:0070781	response to biotin
0.36	GO:0043051	regulation of pharyngeal pumping
0.36	GO:0043327	chemotaxis to cAMP

0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.60	GO:0003707	steroid hormone receptor activity
0.33	GO:0008168	methyltransferase activity
0.33	GO:0005515	protein binding
0.32	GO:0004672	protein kinase activity

0.61	GO:0005634	nucleus
0.33	GO:0005615	extracellular space
0.30	GO:0016020	membrane

0.33

GO:0008168

tr|T1EIM3|T1EIM3_HELRO
Uncharacterized protein
Search

0.51	GO:0090336	positive regulation of brown fat cell differentiation
0.51	GO:0050872	white fat cell differentiation
0.51	GO:2001141	regulation of RNA biosynthetic process
0.51	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.50	GO:0043586	tongue development
0.50	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.50	GO:0010468	regulation of gene expression
0.49	GO:0043457	regulation of cellular respiration
0.49	GO:0035019	somatic stem cell population maintenance
0.49	GO:0060021	palate development

0.51	GO:0003676	nucleic acid binding
0.50	GO:0033613	activating transcription factor binding
0.49	GO:0046332	SMAD binding
0.47	GO:0003713	transcription coactivator activity
0.34	GO:0018024	histone-lysine N-methyltransferase activity
0.34	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.33	GO:0046872	metal ion binding
0.32	GO:0003700	DNA binding transcription factor activity

0.51	GO:0016235	aggresome
0.47	GO:0017053	transcriptional repressor complex
0.45	GO:0005654	nucleoplasm
0.44	GO:0005829	cytosol

0.34

EC:2.1.1.43

GO:0018024

tr|T1EIM4|T1EIM4_HELRO
Uncharacterized protein
Search

tr|T1EIM5|T1EIM5_HELRO
Uncharacterized protein
Search

0.61	GO:0006509	membrane protein ectodomain proteolysis
0.61	GO:0007229	integrin-mediated signaling pathway
0.46	GO:0045766	positive regulation of angiogenesis
0.45	GO:0007507	heart development
0.39	GO:0009405	pathogenesis
0.34	GO:0030198	extracellular matrix organization
0.34	GO:0035893	negative regulation of platelet aggregation in other organism
0.34	GO:0048646	anatomical structure formation involved in morphogenesis
0.34	GO:0007155	cell adhesion
0.34	GO:0030154	cell differentiation

0.69	GO:0004222	metalloendopeptidase activity
0.60	GO:0017124	SH3 domain binding
0.53	GO:0046872	metal ion binding
0.40	GO:0090729	toxin activity
0.33	GO:0016504	peptidase activator activity

0.52	GO:0005794	Golgi apparatus
0.43	GO:0005615	extracellular space
0.42	GO:0005654	nucleoplasm
0.38	GO:0005886	plasma membrane
0.34	GO:0005619	ascospore wall
0.33	GO:0009986	cell surface
0.33	GO:0098552	side of membrane
0.33	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.69