Queries 1 to 1000

GO:0004252

sp|Q01622|HLOX2_HELRO
Homeobox protein LOX2 (Fragment)
Search

0.92	Homeobox protein LOX2

0.61	GO:0007275	multicellular organism development
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.52	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
0.51	GO:0009653	anatomical structure morphogenesis
0.51	GO:0002376	immune system process
0.47	GO:0006366	transcription by RNA polymerase II
0.46	GO:0048872	homeostasis of number of cells
0.46	GO:1902680	positive regulation of RNA biosynthetic process

0.63	GO:0043565	sequence-specific DNA binding
0.54	GO:0003700	DNA binding transcription factor activity
0.48	GO:0001012	RNA polymerase II regulatory region DNA binding
0.46	GO:0003690	double-stranded DNA binding
0.33	GO:0005515	protein binding
0.33	GO:0003723	RNA binding
0.33	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.32	GO:0009982	pseudouridine synthase activity
0.32	GO:0003887	DNA-directed DNA polymerase activity
0.32	GO:1901265	nucleoside phosphate binding

0.61	GO:0005634	nucleus
0.44	GO:0005829	cytosol
0.44	GO:0031974	membrane-enclosed lumen
0.40	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:2.7.10.2

GO:0004715

tr|Q25122|Q25122_HELRO
Hro-Cdc25
Search

0.84	GO:1902751	positive regulation of cell cycle G2/M phase transition
0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.51	GO:0045931	positive regulation of mitotic cell cycle
0.50	GO:0007144	female meiosis I
0.50	GO:0001556	oocyte maturation
0.49	GO:0032467	positive regulation of cytokinesis
0.47	GO:0009794	regulation of mitotic cell cycle, embryonic
0.46	GO:0045860	positive regulation of protein kinase activity
0.44	GO:0010256	endomembrane system organization
0.43	GO:0060305	regulation of cell diameter

0.75	GO:0004725	protein tyrosine phosphatase activity
0.47	GO:0019901	protein kinase binding
0.35	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.34	GO:0050699	WW domain binding

0.48	GO:0005819	spindle
0.46	GO:0005813	centrosome
0.44	GO:0005634	nucleus
0.38	GO:0005694	chromosome
0.37	GO:0005737	cytoplasm
0.34	GO:0048475	coated membrane
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0098796	membrane protein complex

0.75

GO:0004725

tr|T1ECX9|T1ECX9_HELRO
Uncharacterized protein
Search

0.11	Protein arginine N-methyltransferase 7

0.73	GO:0008213	protein alkylation
0.67	GO:0043414	macromolecule methylation
0.50	GO:0018195	peptidyl-arginine modification
0.45	GO:0016570	histone modification
0.44	GO:0006349	regulation of gene expression by genetic imprinting
0.42	GO:0000387	spliceosomal snRNP assembly
0.40	GO:0022412	cellular process involved in reproduction in multicellular organism
0.40	GO:0007276	gamete generation
0.39	GO:0006305	DNA alkylation
0.39	GO:0044728	DNA methylation or demethylation

0.63	GO:0008168	methyltransferase activity
0.41	GO:0140096	catalytic activity, acting on a protein
0.39	GO:0043021	ribonucleoprotein complex binding

0.43	GO:0005829	cytosol
0.41	GO:0001650	fibrillar center
0.38	GO:0005654	nucleoplasm

0.63

GO:0008168

tr|T1ECY0|T1ECY0_HELRO
Uncharacterized protein
Search

SF3B3

0.88	Splicing factor 3b subunit 3

0.53	GO:0042177	negative regulation of protein catabolic process
0.42	GO:0000398	mRNA splicing, via spliceosome
0.33	GO:0006461	protein complex assembly

0.50	GO:0003676	nucleic acid binding
0.49	GO:0032403	protein complex binding

0.59	GO:0005634	nucleus
0.46	GO:0031974	membrane-enclosed lumen
0.44	GO:0030529	intracellular ribonucleoprotein complex
0.44	GO:1902494	catalytic complex
0.43	GO:0043232	intracellular non-membrane-bounded organelle
0.42	GO:0044446	intracellular organelle part
0.34	GO:0120114	Sm-like protein family complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1ECY1|T1ECY1_HELRO
Uncharacterized protein
Search

0.69	Vesicle membrane protein v-SNARE with acyltransferase activity

0.68	GO:0016192	vesicle-mediated transport
0.46	GO:0090174	organelle membrane fusion
0.45	GO:0016050	vesicle organization
0.42	GO:0032940	secretion by cell

0.45	GO:0000149	SNARE binding
0.45	GO:0005484	SNAP receptor activity
0.34	GO:0016746	transferase activity, transferring acyl groups

0.46	GO:0031201	SNARE complex
0.30	GO:0031224	intrinsic component of membrane

0.34

EC:2.3

GO:0016746

tr|T1ECY2|T1ECY2_HELRO
Uncharacterized protein
Search

ABCG2

0.89	Placenta-specific ATP-binding cassette transporter

0.49	GO:0046415	urate metabolic process
0.48	GO:0033344	cholesterol efflux
0.48	GO:0055085	transmembrane transport
0.43	GO:0015893	drug transport
0.38	GO:0097744	urate salt excretion
0.37	GO:1904612	response to 2,3,7,8-tetrachlorodibenzodioxine
0.37	GO:0019389	glucuronoside metabolic process
0.37	GO:1904479	negative regulation of intestinal absorption
0.37	GO:0060136	embryonic process involved in female pregnancy
0.37	GO:0051593	response to folic acid

0.61	GO:0016887	ATPase activity
0.55	GO:0015399	primary active transmembrane transporter activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0017127	cholesterol transporter activity
0.45	GO:0042803	protein homodimerization activity
0.37	GO:0042910	xenobiotic transmembrane transporter activity
0.36	GO:0015238	drug transmembrane transporter activity
0.35	GO:0008092	cytoskeletal protein binding

0.46	GO:0016324	apical plasma membrane
0.45	GO:0043235	receptor complex
0.41	GO:0005634	nucleus
0.36	GO:0031966	mitochondrial membrane
0.36	GO:0043190	ATP-binding cassette (ABC) transporter complex

0.61

GO:0016887

tr|T1ECY3|T1ECY3_HELRO
Uncharacterized protein
Search

tr|T1ECY4|T1ECY4_HELRO
Protein-serine/threonine kinase
Search

GRK5

0.70	G protein-coupled receptor kinase

0.63	GO:0006468	protein phosphorylation
0.61	GO:0007165	signal transduction
0.52	GO:0008284	positive regulation of cell proliferation
0.52	GO:0043066	negative regulation of apoptotic process
0.49	GO:0051726	regulation of cell cycle
0.48	GO:0045444	fat cell differentiation
0.38	GO:0006915	apoptotic process
0.38	GO:0198738	cell-cell signaling by wnt
0.37	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.35	GO:0022401	negative adaptation of signaling pathway

0.85	GO:0004703	G-protein coupled receptor kinase activity
0.59	GO:0047696	beta-adrenergic receptor kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0008289	lipid binding
0.35	GO:0005080	protein kinase C binding

0.52	GO:0016607	nuclear speck
0.52	GO:0031965	nuclear membrane
0.47	GO:0005829	cytosol
0.42	GO:0005886	plasma membrane

0.85

EC:2.7.11.16

GO:0004703

tr|T1ECY5|T1ECY5_HELRO
Uncharacterized protein
Search

0.78	BRCA1 associated protein variant (Fragment)

0.51	GO:0007265	Ras protein signal transduction
0.50	GO:0000165	MAPK cascade
0.47	GO:0009968	negative regulation of signal transduction
0.47	GO:0016567	protein ubiquitination

0.63	GO:0008270	zinc ion binding
0.52	GO:0008139	nuclear localization sequence binding
0.49	GO:0061630	ubiquitin protein ligase activity
0.47	GO:0042802	identical protein binding
0.47	GO:0003676	nucleic acid binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.50	GO:0031965	nuclear membrane
0.48	GO:0000151	ubiquitin ligase complex
0.46	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

tr|T1ECY6|T1ECY6_HELRO
Uncharacterized protein
Search

GLUCL

0.71	Glutamate-gated chloride channel protein splice variant BL

0.61	GO:0007165	signal transduction
0.60	GO:0034220	ion transmembrane transport
0.37	GO:0006821	chloride transport
0.36	GO:0060078	regulation of postsynaptic membrane potential
0.36	GO:0007268	chemical synaptic transmission
0.35	GO:0043200	response to amino acid
0.33	GO:0032447	protein urmylation
0.33	GO:0034227	tRNA thio-modification
0.33	GO:0002098	tRNA wobble uridine modification
0.33	GO:0006468	protein phosphorylation

0.75	GO:0005230	extracellular ligand-gated ion channel activity
0.70	GO:0004888	transmembrane signaling receptor activity
0.37	GO:0005254	chloride channel activity
0.37	GO:0016594	glycine binding
0.37	GO:0099095	ligand-gated anion channel activity
0.35	GO:0022835	transmitter-gated channel activity
0.33	GO:0044877	macromolecular complex binding
0.33	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0000049	tRNA binding
0.32	GO:0016779	nucleotidyltransferase activity

0.55	GO:0005886	plasma membrane
0.36	GO:0098794	postsynapse
0.31	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.33

GO:0004674

tr|T1ECY7|T1ECY7_HELRO
Uncharacterized protein
Search

PPAN

0.37	Peter pan homolog (Drosophila)

0.59	GO:0000027	ribosomal large subunit assembly
0.54	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
0.39	GO:0001560	regulation of cell growth by extracellular stimulus
0.32	GO:0055085	transmembrane transport

0.54	GO:0045028	G-protein coupled purinergic nucleotide receptor activity
0.52	GO:0019843	rRNA binding
0.32	GO:0022857	transmembrane transporter activity

0.61	GO:0030687	preribosome, large subunit precursor
0.43	GO:0005634	nucleus
0.39	GO:0031974	membrane-enclosed lumen
0.37	GO:0043232	intracellular non-membrane-bounded organelle
0.37	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

tr|T1ECY8|T1ECY8_HELRO
Uncharacterized protein
Search

PPP1R8

0.93	Nuclear inhibitor of protein phosphatase

0.77	GO:0043666	regulation of phosphoprotein phosphatase activity
0.73	GO:0008283	cell proliferation
0.63	GO:0035308	negative regulation of protein dephosphorylation
0.62	GO:0010923	negative regulation of phosphatase activity
0.42	GO:0008380	RNA splicing
0.41	GO:0006397	mRNA processing
0.39	GO:0006886	intracellular protein transport
0.39	GO:0061025	membrane fusion
0.39	GO:0016192	vesicle-mediated transport
0.38	GO:0006351	transcription, DNA-templated

0.78	GO:0019888	protein phosphatase regulator activity
0.63	GO:0019212	phosphatase inhibitor activity
0.58	GO:0003729	mRNA binding
0.41	GO:0005484	SNAP receptor activity
0.38	GO:0008995	ribonuclease E activity
0.37	GO:0003677	DNA binding
0.36	GO:0004519	endonuclease activity

0.79	GO:0016607	nuclear speck
0.43	GO:0005681	spliceosomal complex
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

tr|T1ECY9|T1ECY9_HELRO
Uncharacterized protein
Search

0.10	Cyclin-dependent kinase 13

0.63	GO:0006468	protein phosphorylation
0.46	GO:2000737	negative regulation of stem cell differentiation
0.46	GO:0000380	alternative mRNA splicing, via spliceosome
0.45	GO:0006357	regulation of transcription by RNA polymerase II
0.44	GO:0006368	transcription elongation from RNA polymerase II promoter
0.43	GO:0030097	hemopoiesis
0.42	GO:0051726	regulation of cell cycle
0.42	GO:0045893	positive regulation of transcription, DNA-templated
0.38	GO:0051301	cell division
0.35	GO:0033043	regulation of organelle organization

0.64	GO:0004672	protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0030332	cyclin binding
0.43	GO:0019901	protein kinase binding
0.42	GO:0044212	transcription regulatory region DNA binding
0.41	GO:0008134	transcription factor binding
0.40	GO:0060089	molecular transducer activity

0.51	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex
0.47	GO:0002945	cyclin K-CDK13 complex
0.44	GO:0031981	nuclear lumen
0.44	GO:0032806	carboxy-terminal domain protein kinase complex
0.42	GO:0005794	Golgi apparatus
0.42	GO:0005694	chromosome
0.41	GO:0005829	cytosol
0.35	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0005615	extracellular space
0.34	GO:0005885	Arp2/3 protein complex

0.33

GO:0016620

tr|T1ECZ0|T1ECZ0_HELRO
Uncharacterized protein
Search

UNC50

0.95	Unc-50 inner nuclear membrane RNA binding protein

0.40	GO:0007179	transforming growth factor beta receptor signaling pathway
0.39	GO:0097120	receptor localization to synapse
0.38	GO:0006937	regulation of muscle contraction
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0010468	regulation of gene expression
0.35	GO:0015031	protein transport

0.36	GO:0003700	DNA binding transcription factor activity
0.35	GO:0003677	DNA binding
0.33	GO:0003723	RNA binding

0.43	GO:0030173	integral component of Golgi membrane
0.39	GO:0005667	transcription factor complex
0.37	GO:0005634	nucleus
0.34	GO:0019866	organelle inner membrane

tr|T1ECZ1|T1ECZ1_HELRO
Tubulin gamma chain
Search

TUBG1

0.70	Tubulin gamma chain

0.84	GO:0031122	cytoplasmic microtubule organization
0.81	GO:0007020	microtubule nucleation
0.46	GO:0000212	meiotic spindle organization
0.37	GO:1903047	mitotic cell cycle process
0.36	GO:0051726	regulation of cell cycle
0.36	GO:0010457	centriole-centriole cohesion
0.35	GO:0051304	chromosome separation
0.35	GO:0097711	ciliary basal body-plasma membrane docking
0.35	GO:0000819	sister chromatid segregation
0.35	GO:0000280	nuclear division

0.68	GO:0003924	GTPase activity
0.65	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0042802	identical protein binding
0.36	GO:0051011	microtubule minus-end binding
0.35	GO:0005200	structural constituent of cytoskeleton

0.83	GO:0000930	gamma-tubulin complex
0.73	GO:0005874	microtubule
0.53	GO:0000242	pericentriolar material
0.49	GO:0005819	spindle
0.46	GO:0055037	recycling endosome
0.45	GO:0036064	ciliary basal body
0.44	GO:0097730	non-motile cilium
0.44	GO:0005814	centriole
0.44	GO:0045177	apical part of cell
0.44	GO:0031252	cell leading edge

tr|T1ECZ2|T1ECZ2_HELRO
Uncharacterized protein
Search

FICD

0.83	FIC domain containing

0.85	GO:1903894	regulation of IRE1-mediated unfolded protein response
0.85	GO:0018117	protein adenylylation
0.77	GO:0034976	response to endoplasmic reticulum stress

0.85	GO:0070733	protein adenylyltransferase activity
0.84	GO:0030544	Hsp70 protein binding
0.74	GO:0051087	chaperone binding
0.73	GO:0042803	protein homodimerization activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding

0.75

GO:0030176

integral component of endoplasmic reticulum membrane

tr|T1ECZ3|T1ECZ3_HELRO
Glycylpeptide N-tetradecanoyltransferase
Search

0.42	Glycylpeptide N-tetradecanoyltransferase

0.85	GO:0006499	N-terminal protein myristoylation
0.55	GO:0018201	peptidyl-glycine modification
0.48	GO:0001701	in utero embryonic development
0.46	GO:0042180	cellular ketone metabolic process
0.35	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
0.35	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
0.35	GO:0022400	regulation of rhodopsin mediated signaling pathway
0.34	GO:1903749	positive regulation of establishment of protein localization to mitochondrion
0.34	GO:1905477	positive regulation of protein localization to membrane

0.85	GO:0004379	glycylpeptide N-tetradecanoyltransferase activity
0.34	GO:0000062	fatty-acyl-CoA binding
0.32	GO:0003677	DNA binding

0.47	GO:0019898	extrinsic component of membrane
0.45	GO:0005829	cytosol
0.40	GO:0005886	plasma membrane
0.33	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

0.85

EC:2.3.1.97

GO:0004379

tr|T1ECZ4|T1ECZ4_HELRO
Elongation factor 1-alpha
Search

0.45	Translation elongation factor EF-1, subunit alpha

0.70	GO:0006414	translational elongation
0.35	GO:0009792	embryo development ending in birth or egg hatching
0.35	GO:0040007	growth
0.33	GO:0030001	metal ion transport
0.33	GO:0032259	methylation
0.32	GO:0055085	transmembrane transport

0.71	GO:0003746	translation elongation factor activity
0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0046873	metal ion transmembrane transporter activity
0.33	GO:0008168	methyltransferase activity
0.33	GO:0016779	nucleotidyltransferase activity

0.48	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.33

GO:0008168

tr|T1ECZ5|T1ECZ5_HELRO
6-phosphogluconate dehydrogenase, decarboxylating
Search

PGD

0.57	6-phosphogluconate dehydrogenase, decarboxylating

0.79	GO:0019521	D-gluconate metabolic process
0.71	GO:0006098	pentose-phosphate shunt
0.52	GO:0055114	oxidation-reduction process
0.49	GO:0019322	pentose biosynthetic process
0.34	GO:0050829	defense response to Gram-negative bacterium
0.34	GO:0042593	glucose homeostasis
0.34	GO:0007018	microtubule-based movement
0.33	GO:0010629	negative regulation of gene expression

0.74	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
0.36	GO:0046982	protein heterodimerization activity
0.35	GO:0008114	phosphogluconate 2-dehydrogenase activity
0.34	GO:0003777	microtubule motor activity
0.33	GO:0031406	carboxylic acid binding
0.33	GO:0030246	carbohydrate binding
0.33	GO:0050661	NADP binding

0.37	GO:0071821	FANCM-MHF complex
0.36	GO:0070062	extracellular exosome
0.33	GO:0005829	cytosol

0.74

EC:1.1.1.44

GO:0004616

tr|T1ECZ6|T1ECZ6_HELRO
Uncharacterized protein
Search

MED6

0.73	Mediator of RNA polymerase II transcription subunit

0.71	GO:0006357	regulation of transcription by RNA polymerase II
0.54	GO:0006351	transcription, DNA-templated
0.42	GO:0065004	protein-DNA complex assembly
0.39	GO:0007406	negative regulation of neuroblast proliferation
0.38	GO:0006825	copper ion transport

0.79	GO:0001104	RNA polymerase II transcription cofactor activity
0.44	GO:0003713	transcription coactivator activity
0.44	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.39	GO:0016531	copper chaperone activity

0.77	GO:0016592	mediator complex
0.44	GO:0070847	core mediator complex
0.38	GO:0005758	mitochondrial intermembrane space
0.35	GO:0042721	mitochondrial inner membrane protein insertion complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1ECZ7|T1ECZ7_HELRO
Uncharacterized protein
Search

LSM8

0.91	Small nuclear ribonucleoprotein (SnRNP) splicing factor

0.75	GO:0000398	mRNA splicing, via spliceosome
0.43	GO:0030217	T cell differentiation
0.32	GO:0008643	carbohydrate transport
0.32	GO:0055085	transmembrane transport

0.40	GO:0016740	transferase activity
0.40	GO:0003723	RNA binding
0.33	GO:0005515	protein binding
0.32	GO:0022857	transmembrane transporter activity

0.84	GO:0005688	U6 snRNP
0.81	GO:0046540	U4/U6 x U5 tri-snRNP complex
0.47	GO:0071011	precatalytic spliceosome
0.40	GO:0019013	viral nucleocapsid
0.33	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.40

GO:0016740

tr|T1ECZ8|T1ECZ8_HELRO
Uncharacterized protein
Search

0.76	Paramyosin

0.41	GO:0007018	microtubule-based movement
0.35	GO:0008654	phospholipid biosynthetic process
0.33	GO:0007049	cell cycle
0.33	GO:0006606	protein import into nucleus
0.32	GO:0071103	DNA conformation change
0.32	GO:0007004	telomere maintenance via telomerase
0.32	GO:0000722	telomere maintenance via recombination
0.32	GO:0016233	telomere capping
0.32	GO:0035825	homologous recombination
0.32	GO:0007059	chromosome segregation

0.72	GO:0003774	motor activity
0.41	GO:0051015	actin filament binding
0.41	GO:0008017	microtubule binding
0.36	GO:0030554	adenyl nucleotide binding
0.36	GO:0032553	ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0016780	phosphotransferase activity, for other substituted phosphate groups
0.32	GO:0051880	G-quadruplex DNA binding
0.32	GO:0003691	double-stranded telomeric DNA binding

0.77	GO:0016459	myosin complex
0.46	GO:0030016	myofibril
0.35	GO:0005576	extracellular region
0.32	GO:0005694	chromosome
0.32	GO:0030870	Mre11 complex
0.32	GO:0031981	nuclear lumen
0.30	GO:0031224	intrinsic component of membrane

0.35

EC:2.7.8

GO:0016780

tr|T1ECZ9|T1ECZ9_HELRO
Uncharacterized protein
Search

SEL1L

0.88	Putative extracellular protein sel-1

0.55	GO:1903513	endoplasmic reticulum to cytosol transport
0.55	GO:0032527	protein exit from endoplasmic reticulum
0.54	GO:0036503	ERAD pathway
0.53	GO:0006641	triglyceride metabolic process
0.48	GO:0009306	protein secretion
0.39	GO:0007219	Notch signaling pathway
0.37	GO:0045746	negative regulation of Notch signaling pathway
0.35	GO:1904380	endoplasmic reticulum mannose trimming
0.34	GO:0050821	protein stabilization
0.34	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

0.34	GO:0005515	protein binding
0.31	GO:0016740	transferase activity

0.55	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex
0.55	GO:0036513	Derlin-1 retrotranslocation complex
0.35	GO:0044322	endoplasmic reticulum quality control compartment
0.35	GO:0031410	cytoplasmic vesicle
0.30	GO:0016021	integral component of membrane

0.31

GO:0016740

tr|T1ED00|T1ED00_HELRO
Uncharacterized protein
Search

ARIH1

0.58	RING-type E3 ubiquitin transferase

0.72	GO:0016567	protein ubiquitination
0.46	GO:0006511	ubiquitin-dependent protein catabolic process
0.43	GO:1901800	positive regulation of proteasomal protein catabolic process
0.43	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
0.42	GO:0007029	endoplasmic reticulum organization
0.41	GO:0048477	oogenesis
0.41	GO:0050769	positive regulation of neurogenesis
0.32	GO:0055085	transmembrane transport

0.73	GO:0004842	ubiquitin-protein transferase activity
0.54	GO:0046872	metal ion binding
0.51	GO:0031624	ubiquitin conjugating enzyme binding
0.49	GO:0016874	ligase activity
0.45	GO:0061659	ubiquitin-like protein ligase activity
0.43	GO:0031625	ubiquitin protein ligase binding
0.38	GO:0046983	protein dimerization activity
0.36	GO:0036402	proteasome-activating ATPase activity
0.33	GO:0004252	serine-type endopeptidase activity
0.33	GO:0030554	adenyl nucleotide binding

0.47	GO:0097413	Lewy body
0.46	GO:0031462	Cul2-RING ubiquitin ligase complex
0.46	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex
0.45	GO:0019005	SCF ubiquitin ligase complex
0.45	GO:0031463	Cul3-RING ubiquitin ligase complex
0.43	GO:0016604	nuclear body
0.37	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.49	EC:6	GO:0016874
0.73	KEGG:R03876	GO:0004842

tr|T1ED01|T1ED01_HELRO
Uncharacterized protein
Search

0.10	Coiled-coil domain-containing protein 186 (Fragment)

0.36	GO:1990502	dense core granule maturation
0.36	GO:0090325	regulation of locomotion involved in locomotory behavior
0.34	GO:0007165	signal transduction

0.50	GO:0017137	Rab GTPase binding
0.34	GO:0004871	signal transducer activity

0.49	GO:0005802	trans-Golgi network
0.35	GO:0043025	neuronal cell body
0.35	GO:0030424	axon
0.35	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0044425	membrane part

tr|T1ED02|T1ED02_HELRO
Uncharacterized protein
Search

0.56	GO:0031018	endocrine pancreas development
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.55	GO:0001889	liver development
0.54	GO:0048565	digestive tract development
0.54	GO:2000675	negative regulation of type B pancreatic cell apoptotic process
0.54	GO:0007263	nitric oxide mediated signal transduction
0.53	GO:0042593	glucose homeostasis
0.53	GO:0035883	enteroendocrine cell differentiation

0.64	GO:0043565	sequence-specific DNA binding
0.55	GO:0003700	DNA binding transcription factor activity
0.48	GO:0001012	RNA polymerase II regulatory region DNA binding
0.48	GO:0003682	chromatin binding
0.46	GO:0003690	double-stranded DNA binding
0.35	GO:0032403	protein complex binding
0.35	GO:0046982	protein heterodimerization activity
0.35	GO:0008134	transcription factor binding

0.61	GO:0005634	nucleus
0.45	GO:0070013	intracellular organelle lumen
0.41	GO:0044446	intracellular organelle part
0.38	GO:0005829	cytosol
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016020	membrane

tr|T1ED03|T1ED03_HELRO
Uncharacterized protein
Search

0.61	GO:0006508	proteolysis
0.42	GO:0007341	penetration of zona pellucida
0.42	GO:0007190	activation of adenylate cyclase activity
0.41	GO:0050878	regulation of body fluid levels
0.41	GO:2000097	regulation of smooth muscle cell-matrix adhesion
0.41	GO:0007340	acrosome reaction
0.41	GO:0007339	binding of sperm to zona pellucida
0.41	GO:0014909	smooth muscle cell migration
0.40	GO:2000331	regulation of terminal button organization
0.40	GO:0014910	regulation of smooth muscle cell migration

0.69	GO:0004252	serine-type endopeptidase activity
0.41	GO:0005537	mannose binding
0.37	GO:0005044	scavenger receptor activity
0.36	GO:0005509	calcium ion binding
0.36	GO:0005515	protein binding
0.36	GO:0016301	kinase activity
0.35	GO:0090729	toxin activity
0.35	GO:0042806	fucose binding
0.34	GO:0030545	receptor regulator activity
0.34	GO:0004040	amidase activity

0.45	GO:0030141	secretory granule
0.44	GO:0097223	sperm part
0.41	GO:0005576	extracellular region
0.38	GO:0009986	cell surface
0.36	GO:0044437	vacuolar part
0.36	GO:0043234	protein complex
0.36	GO:0044433	cytoplasmic vesicle part
0.35	GO:0005783	endoplasmic reticulum
0.34	GO:0005798	Golgi-associated vesicle
0.34	GO:0005766	primary lysosome

0.69

GO:0004252

tr|T1ED04|T1ED04_HELRO
Uncharacterized protein
Search

SUMF1

0.71	Sulfatase-modifying factor 1

0.39	GO:0006687	glycosphingolipid metabolic process
0.38	GO:0043687	post-translational protein modification
0.38	GO:0055114	oxidation-reduction process
0.35	GO:0016310	phosphorylation

0.66	GO:0042803	protein homodimerization activity
0.38	GO:0046872	metal ion binding
0.38	GO:0016491	oxidoreductase activity
0.35	GO:0016301	kinase activity

0.66	GO:0005783	endoplasmic reticulum
0.40	GO:0043233	organelle lumen
0.38	GO:0044446	intracellular organelle part
0.30	GO:0044425	membrane part

0.38

GO:0016491

tr|T1ED05|T1ED05_HELRO
Uncharacterized protein
Search

0.58	GO:0006397	mRNA processing
0.45	GO:0009725	response to hormone
0.45	GO:2001141	regulation of RNA biosynthetic process
0.44	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.44	GO:0071396	cellular response to lipid
0.44	GO:0010468	regulation of gene expression
0.44	GO:0071407	cellular response to organic cyclic compound
0.43	GO:0006351	transcription, DNA-templated
0.43	GO:0071495	cellular response to endogenous stimulus
0.41	GO:0048856	anatomical structure development

0.47	GO:0003723	RNA binding
0.47	GO:0046872	metal ion binding
0.45	GO:0140110	transcription regulator activity
0.45	GO:0003707	steroid hormone receptor activity
0.42	GO:0043565	sequence-specific DNA binding
0.37	GO:0005086	ARF guanyl-nucleotide exchange factor activity
0.37	GO:0044212	transcription regulatory region DNA binding
0.36	GO:0008134	transcription factor binding
0.36	GO:0003924	GTPase activity
0.36	GO:0030371	translation repressor activity

0.46	GO:0005634	nucleus
0.39	GO:0070013	intracellular organelle lumen
0.39	GO:0005856	cytoskeleton
0.39	GO:0043234	protein complex
0.38	GO:0044446	intracellular organelle part
0.37	GO:0031248	protein acetyltransferase complex
0.37	GO:1905368	peptidase complex
0.36	GO:0045180	basal cortex
0.36	GO:0045179	apical cortex
0.35	GO:0005886	plasma membrane

tr|T1ED06|T1ED06_HELRO
Uncharacterized protein
Search

0.61	Neurohemerythrin

0.39	GO:0015671	oxygen transport
0.34	GO:0046686	response to cadmium ion
0.34	GO:0035940	negative regulation of peptidase activity in other organism
0.33	GO:0035899	negative regulation of blood coagulation in other organism
0.33	GO:0007596	blood coagulation
0.32	GO:0007165	signal transduction

0.62	GO:0005506	iron ion binding
0.39	GO:0005344	oxygen carrier activity
0.32	GO:0030414	peptidase inhibitor activity
0.32	GO:0004871	signal transducer activity

0.32	GO:0005576	extracellular region
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1ED07|T1ED07_HELRO
Uncharacterized protein
Search

0.73	Sterile alpha motif SAM domain containing protein

0.46	GO:0046513	ceramide biosynthetic process
0.43	GO:2000303	regulation of ceramide biosynthetic process
0.42	GO:0060305	regulation of cell diameter
0.40	GO:0007030	Golgi organization
0.37	GO:1905371	ceramide phosphoethanolamine metabolic process
0.37	GO:0006686	sphingomyelin biosynthetic process

0.48	GO:0047493	ceramide cholinephosphotransferase activity
0.47	GO:0033188	sphingomyelin synthase activity
0.37	GO:0002950	ceramide phosphoethanolamine synthase activity

0.44	GO:0030176	integral component of endoplasmic reticulum membrane
0.41	GO:0030173	integral component of Golgi membrane
0.38	GO:0005887	integral component of plasma membrane
0.34	GO:0005829	cytosol

0.48	EC:2.7.8.3	GO:0047493
0.48	KEGG:R01891	GO:0047493

tr|T1ED08|T1ED08_HELRO
Uncharacterized protein
Search

0.67	LOW QUALITY PROTEIN: splicing factor 3B subunit 2

0.43	GO:0000398	mRNA splicing, via spliceosome
0.33	GO:0000413	protein peptidyl-prolyl isomerization
0.33	GO:0016032	viral process

0.37	GO:0005515	protein binding
0.34	GO:0003723	RNA binding
0.33	GO:0003755	peptidyl-prolyl cis-trans isomerase activity

0.61	GO:0005634	nucleus
0.44	GO:0120114	Sm-like protein family complex
0.43	GO:0070013	intracellular organelle lumen
0.43	GO:1902494	catalytic complex
0.42	GO:1990904	ribonucleoprotein complex
0.41	GO:0044446	intracellular organelle part

0.33

GO:0003755

tr|T1ED09|T1ED09_HELRO
Innexin
Search

INX

0.53

Innexin

0.59	GO:0006811	ion transport
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.32	GO:0006468	protein phosphorylation

0.33	GO:0004930	G-protein coupled receptor activity
0.32	GO:0004672	protein kinase activity
0.31	GO:0030554	adenyl nucleotide binding
0.31	GO:0097367	carbohydrate derivative binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.81	GO:0005921	gap junction
0.55	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

tr|T1ED10|T1ED10_HELRO
Uncharacterized protein
Search

CHD4

0.77	Chromodomain-helicase-DNA-binding protein Mi-2

0.55	GO:0007098	centrosome cycle
0.54	GO:0007051	spindle organization
0.51	GO:0006325	chromatin organization
0.37	GO:0032502	developmental process
0.36	GO:0032501	multicellular organismal process
0.36	GO:0040007	growth
0.35	GO:0018022	peptidyl-lysine methylation
0.34	GO:0006357	regulation of transcription by RNA polymerase II
0.33	GO:0006364	rRNA processing
0.33	GO:0016567	protein ubiquitination

0.57	GO:0004386	helicase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0046872	metal ion binding
0.48	GO:0003677	DNA binding
0.46	GO:0001103	RNA polymerase II repressing transcription factor binding
0.46	GO:0042826	histone deacetylase binding
0.36	GO:0061628	H3K27me3 modified histone binding

0.61	GO:0090545	CHD-type complex
0.60	GO:0090568	nuclear transcriptional repressor complex
0.58	GO:0000118	histone deacetylase complex
0.44	GO:0005813	centrosome
0.42	GO:0032993	protein-DNA complex
0.38	GO:0043234	protein complex
0.36	GO:0005737	cytoplasm
0.35	GO:0016607	nuclear speck
0.34	GO:0005730	nucleolus
0.30	GO:0016020	membrane

0.33	EC:3.6.1.3	GO:0016887
0.33	KEGG:R03876	GO:0004842

tr|T1ED11|T1ED11_HELRO
3-hydroxy-3-methylglutaryl coenzyme A reductase
Search

HMGCR

0.55	3-hydroxy-3-methylglutaryl coenzyme A reductase

0.74	GO:0015936	coenzyme A metabolic process
0.71	GO:0008299	isoprenoid biosynthetic process
0.55	GO:0006695	cholesterol biosynthetic process
0.53	GO:0008542	visual learning
0.53	GO:0055114	oxidation-reduction process
0.52	GO:0043407	negative regulation of MAP kinase activity
0.51	GO:0051262	protein tetramerization
0.40	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
0.40	GO:0010666	positive regulation of cardiac muscle cell apoptotic process
0.39	GO:0010664	negative regulation of striated muscle cell apoptotic process

0.82	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity
0.70	GO:0050661	NADP binding
0.53	GO:0042282	hydroxymethylglutaryl-CoA reductase activity
0.39	GO:0043168	anion binding
0.39	GO:0051721	protein phosphatase 2A binding
0.37	GO:0042803	protein homodimerization activity

0.72	GO:0005789	endoplasmic reticulum membrane
0.52	GO:0031903	microbody membrane
0.52	GO:0044439	peroxisomal part
0.30	GO:0016021	integral component of membrane

0.82	EC:1.1.1.34	GO:0004420
0.82	KEGG:R02082	GO:0004420

tr|T1ED12|T1ED12_HELRO
Uncharacterized protein
Search

KTI12

0.92	Cyclohex-1-ene-1-carboxyl-coa hydratase

0.64	GO:0002098	tRNA wobble uridine modification
0.60	GO:0006357	regulation of transcription by RNA polymerase II
0.43	GO:0006470	protein dephosphorylation
0.40	GO:0006508	proteolysis

0.65	GO:0003682	chromatin binding
0.43	GO:0004721	phosphoprotein phosphatase activity
0.42	GO:0004252	serine-type endopeptidase activity
0.40	GO:0032559	adenyl ribonucleotide binding
0.39	GO:0008144	drug binding
0.39	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0004222	metalloendopeptidase activity
0.38	GO:0008270	zinc ion binding
0.37	GO:0005515	protein binding
0.36	GO:0003676	nucleic acid binding

0.53	GO:0005634	nucleus
0.44	GO:0005737	cytoplasm
0.38	GO:0005576	extracellular region
0.30	GO:0016020	membrane

0.43

EC:3.1.3.16

GO:0004721

tr|T1ED13|T1ED13_HELRO
Uncharacterized protein
Search

0.39	MFS membrane transporter

0.37	GO:0055085	transmembrane transport
0.35	GO:0060079	excitatory postsynaptic potential
0.34	GO:0035235	ionotropic glutamate receptor signaling pathway
0.33	GO:0006811	ion transport

0.35	GO:0005234	extracellularly glutamate-gated ion channel activity
0.34	GO:0004970	ionotropic glutamate receptor activity

0.35	GO:0098794	postsynapse
0.30	GO:0044425	membrane part

tr|T1ED14|T1ED14_HELRO
Uncharacterized protein
Search

XAB2

0.45	XPA binding protein 2

0.63	GO:0006396	RNA processing
0.49	GO:0016071	mRNA metabolic process
0.45	GO:0007510	cardioblast cell fate determination
0.44	GO:0007443	Malpighian tubule morphogenesis
0.38	GO:0022618	ribonucleoprotein complex assembly
0.34	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.34	GO:0006283	transcription-coupled nucleotide-excision repair
0.33	GO:0016310	phosphorylation
0.33	GO:0006351	transcription, DNA-templated

0.36

GO:0000829

inositol heptakisphosphate kinase activity

0.46	GO:0000974	Prp19 complex
0.45	GO:0005634	nucleus
0.36	GO:1902494	catalytic complex
0.36	GO:0030529	intracellular ribonucleoprotein complex
0.35	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

tr|T1ED15|T1ED15_HELRO
DNA-directed RNA polymerase
Search

0.47	DNA-directed RNA polymerase

0.58	GO:0006351	transcription, DNA-templated
0.46	GO:0000959	mitochondrial RNA metabolic process
0.46	GO:0140053	mitochondrial gene expression
0.34	GO:0007005	mitochondrion organization
0.33	GO:0035556	intracellular signal transduction

0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.55	GO:0003677	DNA binding
0.33	GO:0003723	RNA binding
0.33	GO:0005515	protein binding

0.45	GO:0034245	mitochondrial DNA-directed RNA polymerase complex
0.43	GO:0042645	mitochondrial nucleoid
0.30	GO:0031224	intrinsic component of membrane

0.70

GO:0003899

tr|T1ED16|T1ED16_HELRO
Uncharacterized protein
Search

0.65	GO:0006281	DNA repair
0.62	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.68	GO:0008833	deoxyribonuclease IV (phage-T4-induced) activity
0.63	GO:0008270	zinc ion binding
0.55	GO:0003677	DNA binding
0.44	GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity
0.44	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
0.44	GO:0008311	double-stranded DNA 3'-5' exodeoxyribonuclease activity
0.34	GO:0016853	isomerase activity

0.37	GO:0005634	nucleus
0.37	GO:0005739	mitochondrion

0.68

EC:3.1.21.2

GO:0008833

tr|T1ED17|T1ED17_HELRO
Uncharacterized protein
Search

ANAPC11

0.78	Anaphase-promoting complex subunit

0.73	GO:0016567	protein ubiquitination
0.48	GO:0045842	positive regulation of mitotic metaphase/anaphase transition
0.44	GO:0006511	ubiquitin-dependent protein catabolic process
0.36	GO:0051301	cell division
0.36	GO:0007049	cell cycle
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.34	GO:1904667	negative regulation of ubiquitin protein ligase activity
0.34	GO:0010498	proteasomal protein catabolic process

0.74	GO:0004842	ubiquitin-protein transferase activity
0.49	GO:0097602	cullin family protein binding
0.45	GO:0061659	ubiquitin-like protein ligase activity
0.34	GO:0046872	metal ion binding
0.34	GO:0001664	G-protein coupled receptor binding
0.33	GO:0016874	ligase activity

0.80	GO:0005680	anaphase-promoting complex
0.35	GO:0005730	nucleolus
0.34	GO:0005654	nucleoplasm
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.33	EC:6	GO:0016874
0.74	KEGG:R03876	GO:0004842

tr|T1ED18|T1ED18_HELRO
Uncharacterized protein
Search

0.62	Neurohemerythrin

0.40	GO:0015671	oxygen transport
0.34	GO:0046686	response to cadmium ion
0.33	GO:0007165	signal transduction

0.63	GO:0005506	iron ion binding
0.40	GO:0005344	oxygen carrier activity
0.33	GO:0004871	signal transducer activity

0.32	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

tr|T1ED19|T1ED19_HELRO
Uncharacterized protein
Search

0.82	RNA-binding protein with serine-rich domain

0.41	GO:0006397	mRNA processing
0.40	GO:0008380	RNA splicing
0.39	GO:0000335	negative regulation of transposition, DNA-mediated
0.34	GO:0060079	excitatory postsynaptic potential
0.34	GO:0035235	ionotropic glutamate receptor signaling pathway
0.33	GO:0000055	ribosomal large subunit export from nucleus
0.33	GO:0034220	ion transmembrane transport
0.32	GO:0042273	ribosomal large subunit biogenesis
0.32	GO:0030036	actin cytoskeleton organization
0.32	GO:0006468	protein phosphorylation

0.58	GO:0003723	RNA binding
0.35	GO:0019706	protein-cysteine S-palmitoyltransferase activity
0.34	GO:0005234	extracellularly glutamate-gated ion channel activity
0.34	GO:0004970	ionotropic glutamate receptor activity
0.33	GO:0004499	N,N-dimethylaniline monooxygenase activity
0.33	GO:0046872	metal ion binding
0.32	GO:0050661	NADP binding
0.32	GO:0004672	protein kinase activity
0.32	GO:0004527	exonuclease activity
0.32	GO:0050660	flavin adenine dinucleotide binding

0.39	GO:0016607	nuclear speck
0.34	GO:0098794	postsynapse
0.34	GO:0005737	cytoplasm
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.35

GO:0019706

tr|T1ED20|T1ED20_HELRO
Uncharacterized protein
Search

TMEM145

0.47	Transmembrane protein 145

0.81	GO:0019236	response to pheromone
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.35	GO:0008203	cholesterol metabolic process
0.34	GO:0016042	lipid catabolic process
0.31	GO:1903506	regulation of nucleic acid-templated transcription
0.31	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.31	GO:0010468	regulation of gene expression

0.34	GO:0016298	lipase activity
0.33	GO:0008270	zinc ion binding
0.31	GO:0003700	DNA binding transcription factor activity

0.30

GO:0031224

intrinsic component of membrane

0.34

EC:3.1.1

GO:0016298

tr|T1ED21|T1ED21_HELRO
V-type proton ATPase subunit a
Search

0.39	V-type proton ATPase subunit a

0.75	GO:0015991	ATP hydrolysis coupled proton transport
0.47	GO:0006885	regulation of pH
0.47	GO:0007588	excretion
0.45	GO:0001503	ossification
0.45	GO:0007605	sensory perception of sound
0.43	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly
0.43	GO:0030004	cellular monovalent inorganic cation homeostasis
0.40	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.40	GO:0006754	ATP biosynthetic process
0.36	GO:0016236	macroautophagy

0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.49	GO:0051117	ATPase binding
0.42	GO:0036442	proton-exporting ATPase activity
0.40	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
0.34	GO:0051539	4 iron, 4 sulfur cluster binding
0.34	GO:0016651	oxidoreductase activity, acting on NAD(P)H
0.33	GO:0004820	glycine-tRNA ligase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.81	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain
0.48	GO:0016471	vacuolar proton-transporting V-type ATPase complex
0.46	GO:0016324	apical plasma membrane
0.46	GO:0031526	brush border membrane
0.43	GO:0005768	endosome
0.35	GO:0030659	cytoplasmic vesicle membrane
0.35	GO:0042470	melanosome
0.34	GO:0045335	phagocytic vesicle
0.34	GO:0005765	lysosomal membrane
0.33	GO:0070062	extracellular exosome

0.34

EC:1.6

GO:0016651

tr|T1ED22|T1ED22_HELRO
Uncharacterized protein
Search

SUN3

0.63	SUN domain-containing protein 1

0.52	GO:0007097	nuclear migration
0.48	GO:0006998	nuclear envelope organization
0.48	GO:0021815	modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration
0.47	GO:0090286	cytoskeletal anchoring at nuclear membrane
0.47	GO:0090292	nuclear matrix anchoring at nuclear membrane
0.46	GO:0070197	meiotic attachment of telomere to nuclear envelope
0.46	GO:0051642	centrosome localization
0.45	GO:0007129	synapsis
0.45	GO:0072384	organelle transport along microtubule
0.43	GO:0000724	double-strand break repair via homologous recombination

0.47	GO:0005521	lamin binding
0.44	GO:0043495	protein membrane anchor
0.33	GO:0008094	DNA-dependent ATPase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0003677	DNA binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.72	GO:0106094	nuclear membrane microtubule tethering complex
0.72	GO:0034992	microtubule organizing center attachment site
0.71	GO:0031229	intrinsic component of nuclear inner membrane
0.65	GO:0031301	integral component of organelle membrane
0.46	GO:0002080	acrosomal membrane
0.44	GO:0034399	nuclear periphery
0.44	GO:0048471	perinuclear region of cytoplasm

tr|T1ED23|T1ED23_HELRO
Uncharacterized protein
Search

AARS

0.67	LOW QUALITY PROTEIN: alanine--tRNA ligase, cytoplasmic

0.78	GO:0006419	alanyl-tRNA aminoacylation
0.50	GO:0021680	cerebellar Purkinje cell layer development
0.50	GO:0050885	neuromuscular process controlling balance
0.49	GO:0043524	negative regulation of neuron apoptotic process
0.47	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity
0.45	GO:0006400	tRNA modification
0.35	GO:0140018	regulation of cytoplasmic translational fidelity
0.35	GO:0006413	translational initiation
0.33	GO:0006414	translational elongation

0.78	GO:0004813	alanine-tRNA ligase activity
0.67	GO:0000049	tRNA binding
0.61	GO:0008270	zinc ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0002161	aminoacyl-tRNA editing activity
0.42	GO:0016597	amino acid binding
0.35	GO:0008135	translation factor activity, RNA binding
0.34	GO:0032550	purine ribonucleoside binding

0.49	GO:0005737	cytoplasm
0.37	GO:0043231	intracellular membrane-bounded organelle
0.36	GO:0070062	extracellular exosome
0.33	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.78

EC:6.1.1.7

GO:0004813

tr|T1ED24|T1ED24_HELRO
Uncharacterized protein
Search

0.76	GO:0000226	microtubule cytoskeleton organization
0.55	GO:0008355	olfactory learning
0.55	GO:0060052	neurofilament cytoskeleton organization
0.54	GO:0008582	regulation of synaptic growth at neuromuscular junction
0.54	GO:0008088	axo-dendritic transport
0.53	GO:0048813	dendrite morphogenesis
0.53	GO:0043524	negative regulation of neuron apoptotic process
0.51	GO:0007409	axonogenesis
0.37	GO:0007528	neuromuscular junction development
0.37	GO:0048749	compound eye development

0.74	GO:0008017	microtubule binding
0.50	GO:0019900	kinase binding

0.73	GO:0005874	microtubule
0.51	GO:0043025	neuronal cell body
0.51	GO:0030425	dendrite
0.51	GO:0030424	axon
0.49	GO:0005875	microtubule associated complex
0.33	GO:0005737	cytoplasm

tr|T1ED25|T1ED25_HELRO
Uncharacterized protein
Search

0.97	Mitochondrial calcium uniporter regulator 1

0.85	GO:0006851	mitochondrial calcium ion transmembrane transport
0.61	GO:0051561	positive regulation of mitochondrial calcium ion concentration
0.58	GO:0070509	calcium ion import
0.55	GO:0060401	cytosolic calcium ion transport

0.33

GO:0005515

protein binding

0.56

GO:0031305

integral component of mitochondrial inner membrane

tr|T1ED26|T1ED26_HELRO
Uncharacterized protein
Search

OAT

0.53	'Ornithine aminotransferase, mitochondrial '

0.42	GO:0034214	protein hexamerization
0.36	GO:0055129	L-proline biosynthetic process
0.34	GO:0006591	ornithine metabolic process
0.33	GO:0006468	protein phosphorylation

0.83	GO:0004587	ornithine-oxo-acid transaminase activity
0.67	GO:0030170	pyridoxal phosphate binding
0.40	GO:0042802	identical protein binding
0.35	GO:0008289	lipid binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0005524	ATP binding

0.39	GO:0070013	intracellular organelle lumen
0.38	GO:0005739	mitochondrion
0.37	GO:0044428	nuclear part
0.30	GO:0031224	intrinsic component of membrane

0.83

EC:2.6.1.13

GO:0004587

tr|T1ED27|T1ED27_HELRO
Uncharacterized protein
Search

CLK4

0.47	Serine/threonine-protein kinase Doa

0.63	GO:0006468	protein phosphorylation
0.47	GO:0034125	negative regulation of MyD88-dependent toll-like receptor signaling pathway
0.47	GO:2000255	negative regulation of male germ cell proliferation
0.46	GO:0030717	karyosome formation
0.45	GO:0042051	compound eye photoreceptor development
0.45	GO:0007350	blastoderm segmentation
0.44	GO:0007548	sex differentiation
0.43	GO:0043484	regulation of RNA splicing
0.41	GO:0009306	protein secretion
0.40	GO:0018212	peptidyl-tyrosine modification

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003676	nucleic acid binding

0.41	GO:0005783	endoplasmic reticulum
0.40	GO:0005634	nucleus
0.33	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

tr|T1ED28|T1ED28_HELRO
Uncharacterized protein
Search

USP15

0.77	Ubiquitin carboxyl-terminal hydrolase 4

0.76	GO:0016579	protein deubiquitination
0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.53	GO:0060389	pathway-restricted SMAD protein phosphorylation
0.51	GO:0030509	BMP signaling pathway
0.51	GO:0007179	transforming growth factor beta receptor signaling pathway
0.47	GO:0016570	histone modification
0.36	GO:0034122	negative regulation of toll-like receptor signaling pathway

0.77	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.54	GO:0061649	ubiquitin modification-dependent histone binding
0.52	GO:0005160	transforming growth factor beta receptor binding
0.51	GO:0046332	SMAD binding
0.48	GO:0004197	cysteine-type endopeptidase activity
0.47	GO:0042802	identical protein binding
0.32	GO:0004252	serine-type endopeptidase activity

0.45	GO:0005829	cytosol
0.43	GO:0005634	nucleus
0.36	GO:0005739	mitochondrion

0.77

GO:0036459

tr|T1ED29|T1ED29_HELRO
Uncharacterized protein
Search

RPL23A

0.85	Ribosomal protein L23A, pseudogene 3

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.44	GO:0000027	ribosomal large subunit assembly
0.42	GO:0031016	pancreas development
0.39	GO:0051726	regulation of cell cycle
0.36	GO:0009644	response to high light intensity
0.35	GO:0009409	response to cold
0.35	GO:0006979	response to oxidative stress

0.64	GO:0003735	structural constituent of ribosome
0.39	GO:0003723	RNA binding
0.35	GO:0003935	GTP cyclohydrolase II activity
0.34	GO:0008686	3,4-dihydroxy-2-butanone-4-phosphate synthase activity
0.34	GO:0045296	cadherin binding
0.32	GO:0016491	oxidoreductase activity

0.61	GO:0005840	ribosome
0.43	GO:0044445	cytosolic part
0.38	GO:0044446	intracellular organelle part
0.35	GO:0005844	polysome
0.34	GO:0005794	Golgi apparatus
0.34	GO:0005634	nucleus
0.34	GO:0031932	TORC2 complex
0.33	GO:0055044	symplast
0.33	GO:0005911	cell-cell junction
0.33	GO:0005618	cell wall

0.35	EC:3.5.4.25	GO:0003935
0.35	KEGG:R00425	GO:0003935

tr|T1ED30|T1ED30_HELRO
Uncharacterized protein
Search

0.67	Autophagy-related protein 2-like protein B

0.77	GO:0006914	autophagy
0.46	GO:0061726	mitochondrion disassembly
0.45	GO:0007033	vacuole organization
0.42	GO:0070925	organelle assembly
0.32	GO:0006508	proteolysis
0.32	GO:0055085	transmembrane transport

0.33	GO:0070001	aspartic-type peptidase activity
0.32	GO:0004175	endopeptidase activity

0.45	GO:0000407	phagophore assembly site
0.45	GO:0005654	nucleoplasm
0.43	GO:0019898	extrinsic component of membrane
0.35	GO:0005811	lipid droplet
0.34	GO:0098805	whole membrane
0.33	GO:0005829	cytosol
0.33	GO:0005764	lysosome
0.30	GO:0031224	intrinsic component of membrane

tr|T1ED31|T1ED31_HELRO
Uncharacterized protein
Search

0.87	Membrane-associated protein Hem

0.66	GO:0016601	Rac protein signal transduction
0.66	GO:0010592	positive regulation of lamellipodium assembly
0.64	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation
0.64	GO:0008407	chaeta morphogenesis
0.63	GO:0033627	cell adhesion mediated by integrin
0.62	GO:0007520	myoblast fusion
0.61	GO:0007528	neuromuscular junction development
0.60	GO:0001764	neuron migration
0.60	GO:0030866	cortical actin cytoskeleton organization
0.58	GO:0007417	central nervous system development

0.64	GO:0048365	Rac GTPase binding
0.57	GO:0032403	protein complex binding
0.44	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.43	GO:0032559	adenyl ribonucleotide binding
0.42	GO:0008144	drug binding
0.42	GO:0035639	purine ribonucleoside triphosphate binding

0.77	GO:0031209	SCAR complex
0.48	GO:0031258	lamellipodium membrane
0.44	GO:0031941	filamentous actin
0.43	GO:0001726	ruffle
0.43	GO:0005925	focal adhesion
0.43	GO:0070062	extracellular exosome
0.37	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.44

GO:0032440

tr|T1ED32|T1ED32_HELRO
Uncharacterized protein
Search

0.74	Putative mitochondrial polypeptide chain release factor

0.74	GO:0006415	translational termination
0.47	GO:0072344	rescue of stalled ribosome
0.46	GO:0032543	mitochondrial translation
0.33	GO:0009435	NAD biosynthetic process

0.75	GO:0003747	translation release factor activity
0.45	GO:0004045	aminoacyl-tRNA hydrolase activity
0.33	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity

0.46

GO:0005762

mitochondrial large ribosomal subunit

0.45	EC:3.1.1.29	GO:0004045
0.33	KEGG:R03348	GO:0004514

tr|T1ED33|T1ED33_HELRO
Coatomer subunit beta
Search

COPB1

0.62	Coatomer subunit beta

0.68	GO:0006886	intracellular protein transport
0.68	GO:0016192	vesicle-mediated transport
0.45	GO:0030903	notochord development
0.44	GO:0061053	somite development
0.35	GO:0002283	neutrophil activation involved in immune response
0.35	GO:0002446	neutrophil mediated immunity
0.33	GO:0032940	secretion by cell
0.33	GO:0016032	viral process
0.33	GO:0007165	signal transduction

0.61	GO:0005198	structural molecule activity
0.34	GO:0005515	protein binding
0.33	GO:0003924	GTPase activity
0.33	GO:0005525	GTP binding

0.80	GO:0030126	COPI vesicle coat
0.72	GO:0000139	Golgi membrane
0.47	GO:0005829	cytosol
0.40	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.35	GO:0101003	ficolin-1-rich granule membrane
0.35	GO:0070821	tertiary granule membrane
0.35	GO:0005886	plasma membrane
0.35	GO:0005783	endoplasmic reticulum
0.34	GO:0030133	transport vesicle
0.33	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network

tr|T1ED34|T1ED34_HELRO
Uncharacterized protein
Search

0.36	GO:0042254	ribosome biogenesis
0.35	GO:0006269	DNA replication, synthesis of RNA primer
0.34	GO:0006511	ubiquitin-dependent protein catabolic process
0.34	GO:0006265	DNA topological change
0.34	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression

0.65	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0035091	phosphatidylinositol binding
0.36	GO:0003924	GTPase activity
0.35	GO:0003896	DNA primase activity
0.35	GO:0003700	DNA binding transcription factor activity
0.34	GO:0061505	DNA topoisomerase II activity
0.34	GO:0003779	actin binding

0.35	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

0.35

GO:0003896

tr|T1ED35|T1ED35_HELRO
Spectrin beta chain
Search

0.75	Spectrin beta chain

0.79	GO:0051693	actin filament capping
0.71	GO:0007010	cytoskeleton organization

0.77	GO:0005200	structural constituent of cytoskeleton
0.73	GO:0003779	actin binding
0.56	GO:0005543	phospholipid binding
0.32	GO:0016787	hydrolase activity

0.85	GO:0008091	spectrin
0.30	GO:0044425	membrane part

0.32

GO:0016787

tr|T1ED36|T1ED36_HELRO
Uncharacterized protein
Search

tr|T1ED38|T1ED38_HELRO
Uncharacterized protein
Search

0.54	Ring finger protein 44

0.62	GO:0016567	protein ubiquitination
0.61	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.40	GO:0008584	male gonad development
0.38	GO:0001578	microtubule bundle formation
0.37	GO:0007286	spermatid development
0.36	GO:0000910	cytokinesis

0.63	GO:0004842	ubiquitin-protein transferase activity
0.60	GO:0061659	ubiquitin-like protein ligase activity
0.50	GO:0016874	ligase activity
0.37	GO:0046872	metal ion binding
0.37	GO:0005515	protein binding

0.49	GO:0005654	nucleoplasm
0.40	GO:0036126	sperm flagellum
0.36	GO:0005856	cytoskeleton
0.30	GO:0031224	intrinsic component of membrane

0.50	EC:6	GO:0016874
0.63	KEGG:R03876	GO:0004842

tr|T1ED39|T1ED39_HELRO
Protein CLP1 homolog
Search

CLP1

0.97	Polyribonucleotide 5'-hydroxyl-kinase Clp1

0.79	GO:0031124	mRNA 3'-end processing
0.71	GO:0035087	siRNA loading onto RISC involved in RNA interference
0.67	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation
0.52	GO:0030423	targeting of mRNA for destruction involved in RNA interference
0.51	GO:0007420	brain development
0.51	GO:0016310	phosphorylation
0.46	GO:0006379	mRNA cleavage
0.46	GO:0043631	RNA polyadenylation
0.43	GO:0021522	spinal cord motor neuron differentiation
0.34	GO:0006369	termination of RNA polymerase II transcription

0.73	GO:0051736	ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
0.71	GO:0051733	polydeoxyribonucleotide kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003995	acyl-CoA dehydrogenase activity
0.33	GO:0050660	flavin adenine dinucleotide binding

0.79	GO:0005849	mRNA cleavage factor complex
0.69	GO:0000214	tRNA-intron endonuclease complex
0.44	GO:0005829	cytosol

0.33

EC:1.3.99.3

GO:0003995

tr|T1ED40|T1ED40_HELRO
Uncharacterized protein
Search

CPSF3

0.82	Cleavage and polyadenylation specificity factor subunit

0.86	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage
0.69	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.40	GO:0006369	termination of RNA polymerase II transcription
0.39	GO:0006379	mRNA cleavage
0.39	GO:0006378	mRNA polyadenylation
0.39	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.38	GO:0051028	mRNA transport
0.38	GO:0000398	mRNA splicing, via spliceosome
0.38	GO:0006405	RNA export from nucleus
0.38	GO:0043547	positive regulation of GTPase activity

0.76	GO:0008409	5'-3' exonuclease activity
0.70	GO:0004521	endoribonuclease activity
0.58	GO:0003723	RNA binding
0.38	GO:0005515	protein binding
0.38	GO:0005096	GTPase activator activity
0.37	GO:0046872	metal ion binding

0.81	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
0.40	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0016020	membrane

tr|T1ED41|T1ED41_HELRO
Uncharacterized protein
Search

0.41	Gdp-mannose-dehydratase

0.79	GO:0019673	GDP-mannose metabolic process
0.38	GO:2000035	regulation of stem cell division
0.37	GO:0042350	GDP-L-fucose biosynthetic process
0.37	GO:0007219	Notch signaling pathway
0.37	GO:0048477	oogenesis

0.81	GO:0008446	GDP-mannose 4,6-dehydratase activity
0.51	GO:0070401	NADP+ binding
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.33	GO:0016853	isomerase activity
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.30

GO:0016020

membrane

0.81	EC:4.2.1.47	GO:0008446
0.81	KEGG:R00888	GO:0008446

tr|T1ED42|T1ED42_HELRO
Uncharacterized protein
Search

LOC106176764

0.63	Disks large 1 tumor suppressor protein

0.59	GO:0046710	GDP metabolic process
0.58	GO:0097120	receptor localization to synapse
0.58	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
0.58	GO:0043113	receptor clustering
0.57	GO:0046037	GMP metabolic process
0.56	GO:0007268	chemical synaptic transmission
0.52	GO:0007399	nervous system development
0.49	GO:0019233	sensory perception of pain
0.48	GO:0043297	apical junction assembly
0.48	GO:0016310	phosphorylation

0.59	GO:0035255	ionotropic glutamate receptor binding
0.59	GO:0004385	guanylate kinase activity
0.49	GO:0019900	kinase binding
0.48	GO:0008022	protein C-terminus binding
0.47	GO:0019902	phosphatase binding
0.45	GO:0019904	protein domain specific binding
0.44	GO:0015459	potassium channel regulator activity
0.43	GO:0005154	epidermal growth factor receptor binding
0.43	GO:0044325	ion channel binding
0.42	GO:0045296	cadherin binding

0.59	GO:0014069	postsynaptic density
0.58	GO:0008328	ionotropic glutamate receptor complex
0.57	GO:0045211	postsynaptic membrane
0.56	GO:0016323	basolateral plasma membrane
0.54	GO:0033267	axon part
0.51	GO:0030054	cell junction
0.48	GO:0016328	lateral plasma membrane
0.48	GO:0031594	neuromuscular junction
0.46	GO:0048471	perinuclear region of cytoplasm
0.45	GO:0043219	lateral loop

0.59

EC:2.7.4.8

GO:0004385

tr|T1ED43|T1ED43_HELRO
Uncharacterized protein
Search

0.46	GO:0035634	response to stilbenoid
0.46	GO:0045087	innate immune response
0.45	GO:0060612	adipose tissue development
0.45	GO:1905240	negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation
0.44	GO:0033689	negative regulation of osteoblast proliferation
0.44	GO:0008203	cholesterol metabolic process
0.44	GO:0010906	regulation of glucose metabolic process
0.44	GO:0002076	osteoblast development
0.43	GO:0006956	complement activation
0.42	GO:0006898	receptor-mediated endocytosis

0.45	GO:0005044	scavenger receptor activity
0.43	GO:0140096	catalytic activity, acting on a protein
0.43	GO:0030246	carbohydrate binding
0.43	GO:0005178	integrin binding
0.40	GO:0042802	identical protein binding
0.40	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.40	GO:0046872	metal ion binding
0.39	GO:0016301	kinase activity
0.38	GO:0016787	hydrolase activity
0.36	GO:0032559	adenyl ribonucleotide binding

0.50	GO:0005581	collagen trimer
0.49	GO:0005576	extracellular region
0.45	GO:1990026	hippocampal mossy fiber expansion
0.44	GO:0097442	CA3 pyramidal cell dendrite
0.42	GO:0043025	neuronal cell body
0.41	GO:0031982	vesicle
0.40	GO:0009986	cell surface
0.30	GO:0016020	membrane

0.40

GO:0016773

tr|T1ED44|T1ED44_HELRO
Uncharacterized protein
Search

tr|T1ED45|T1ED45_HELRO
Uncharacterized protein
Search

KPNB1

0.93	Karyopherin (importin) beta 1

0.69

GO:0006886

intracellular protein transport

0.80

GO:0008536

Ran GTPase binding

0.45

GO:0005622

intracellular

tr|T1ED46|T1ED46_HELRO
Dihydroorotate dehydrogenase (quinone), mitochondrial
Search

DHODH

0.49	Dihydroorotate dehydrogenase (quinone), mitochondrial

0.74	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
0.70	GO:0006222	UMP biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.37	GO:1903576	response to L-arginine
0.37	GO:0031000	response to caffeine
0.37	GO:0007595	lactation
0.37	GO:0090140	regulation of mitochondrial fission
0.36	GO:0007565	female pregnancy
0.36	GO:0043065	positive regulation of apoptotic process
0.36	GO:0042594	response to starvation

0.79	GO:0004152	dihydroorotate dehydrogenase activity
0.37	GO:0048039	ubiquinone binding
0.35	GO:0010181	FMN binding
0.34	GO:0004325	ferrochelatase activity
0.33	GO:0004252	serine-type endopeptidase activity
0.33	GO:0003924	GTPase activity
0.33	GO:0005525	GTP binding
0.33	GO:0008144	drug binding
0.33	GO:0008270	zinc ion binding

0.59	GO:0031966	mitochondrial membrane
0.59	GO:0019866	organelle inner membrane
0.41	GO:0005654	nucleoplasm
0.41	GO:0005829	cytosol
0.36	GO:0043025	neuronal cell body
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.79	EC:1.3.5.2	GO:0004152
0.79	KEGG:R01868	GO:0004152

tr|T1ED47|T1ED47_HELRO
Uncharacterized protein
Search

0.79	Catenin alpha

0.72	GO:0007155	cell adhesion
0.53	GO:0060322	head development
0.50	GO:0009653	anatomical structure morphogenesis
0.49	GO:0007417	central nervous system development
0.47	GO:0048513	animal organ development
0.45	GO:0030029	actin filament-based process
0.45	GO:0034333	adherens junction assembly
0.45	GO:0001700	embryonic development via the syncytial blastoderm
0.43	GO:0002064	epithelial cell development
0.41	GO:0097435	supramolecular fiber organization

0.82	GO:0045296	cadherin binding
0.78	GO:0051015	actin filament binding
0.57	GO:0005198	structural molecule activity
0.43	GO:0008013	beta-catenin binding
0.42	GO:0042802	identical protein binding

0.67	GO:0015629	actin cytoskeleton
0.56	GO:0005912	adherens junction
0.52	GO:0005911	cell-cell junction
0.45	GO:0016342	catenin complex
0.39	GO:0005829	cytosol
0.33	GO:0030424	axon
0.32	GO:0005634	nucleus
0.32	GO:0014069	postsynaptic density
0.32	GO:0030027	lamellipodium
0.32	GO:0016323	basolateral plasma membrane

tr|T1ED48|T1ED48_HELRO
Uncharacterized protein
Search

ALG1

0.85	Chitobiosyldiphosphodolichol beta-mannosyltransferase

0.42	GO:0097502	mannosylation
0.41	GO:0006486	protein glycosylation
0.35	GO:0006488	dolichol-linked oligosaccharide biosynthetic process
0.33	GO:0006098	pentose-phosphate shunt
0.33	GO:0033014	tetrapyrrole biosynthetic process
0.32	GO:0005975	carbohydrate metabolic process
0.32	GO:0015801	aromatic amino acid transport
0.32	GO:0003333	amino acid transmembrane transport

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.34	GO:0017057	6-phosphogluconolactonase activity
0.34	GO:0004418	hydroxymethylbilane synthase activity
0.32	GO:0015173	aromatic amino acid transmembrane transporter activity

0.40	GO:0005783	endoplasmic reticulum
0.37	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0031984	organelle subcompartment
0.32	GO:0005887	integral component of plasma membrane

0.65	EC:2.4	GO:0016757
0.34	KEGG:R02035	GO:0017057

tr|T1ED49|T1ED49_HELRO
Coatomer subunit alpha
Search

COPA

0.73	Coatomer subunit alpha

0.69	GO:0006886	intracellular protein transport
0.68	GO:0016192	vesicle-mediated transport
0.56	GO:0030157	pancreatic juice secretion
0.46	GO:1905345	protein localization to cleavage furrow
0.46	GO:0030903	notochord development
0.45	GO:0061053	somite development
0.44	GO:0007112	male meiosis cytokinesis
0.43	GO:0010883	regulation of lipid storage
0.41	GO:0000902	cell morphogenesis
0.36	GO:0010469	regulation of receptor activity

0.61	GO:0005198	structural molecule activity
0.37	GO:0005179	hormone activity
0.32	GO:0016740	transferase activity

0.80	GO:0030126	COPI vesicle coat
0.73	GO:0000139	Golgi membrane
0.48	GO:0005615	extracellular space
0.43	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.36	GO:1903561	extracellular vesicle
0.35	GO:0030133	transport vesicle
0.34	GO:0099503	secretory vesicle
0.34	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0005829	cytosol
0.33	GO:0019028	viral capsid

0.32

GO:0016740

tr|T1ED50|T1ED50_HELRO
Uncharacterized protein
Search

0.70	Serine/threonine-protein phosphatase 4 regulatory subunit 1 (Fragment)

0.77	GO:0043666	regulation of phosphoprotein phosphatase activity
0.59	GO:0007165	signal transduction
0.34	GO:0006470	protein dephosphorylation
0.34	GO:0006468	protein phosphorylation

0.78	GO:0019888	protein phosphatase regulator activity
0.35	GO:0005515	protein binding
0.34	GO:0004721	phosphoprotein phosphatase activity

0.83

GO:0030289

protein phosphatase 4 complex

0.34

EC:3.1.3.16

GO:0004721

tr|T1ED51|T1ED51_HELRO
Uncharacterized protein
Search

0.61	SEC24 homolog B, COPII coat complex component

0.78	GO:0006888	ER to Golgi vesicle-mediated transport
0.69	GO:0006886	intracellular protein transport
0.35	GO:1901301	regulation of cargo loading into COPII-coated vesicle
0.35	GO:0021747	cochlear nucleus development
0.35	GO:0060463	lung lobe morphogenesis
0.35	GO:0060982	coronary artery morphogenesis
0.35	GO:0061156	pulmonary artery morphogenesis
0.35	GO:0090178	regulation of establishment of planar polarity involved in neural tube closure
0.35	GO:0060088	auditory receptor cell stereocilium organization
0.35	GO:0035459	cargo loading into vesicle

0.62	GO:0008270	zinc ion binding
0.30	GO:0003824	catalytic activity

0.80	GO:0030127	COPII vesicle coat
0.34	GO:0000139	Golgi membrane
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1ED52|T1ED52_HELRO
Uncharacterized protein
Search

TMEM104

0.47	General transcription factor IIE TFIIE subunit (Fragment)

0.34	GO:0006662	glycerol ether metabolic process
0.33	GO:0045454	cell redox homeostasis
0.32	GO:0055114	oxidation-reduction process
0.32	GO:0006468	protein phosphorylation

0.33	GO:0015035	protein disulfide oxidoreductase activity
0.32	GO:0004672	protein kinase activity
0.31	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.30	GO:0016021	integral component of membrane
0.30	GO:0005623	cell

tr|T1ED53|T1ED53_HELRO
Uncharacterized protein
Search

CRIP1

0.82	Cysteine-rich intestinal protein 1

0.48	GO:0071236	cellular response to antibiotic
0.48	GO:0071493	cellular response to UV-B
0.47	GO:0010043	response to zinc ion
0.47	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
0.40	GO:0060047	heart contraction
0.39	GO:0007507	heart development

0.54	GO:0046872	metal ion binding
0.47	GO:0003680	AT DNA binding
0.47	GO:0008301	DNA binding, bending
0.45	GO:0042277	peptide binding

0.36	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

tr|T1ED54|T1ED54_HELRO
Uncharacterized protein
Search

0.67	GO:0045454	cell redox homeostasis
0.44	GO:0034976	response to endoplasmic reticulum stress
0.40	GO:0006457	protein folding
0.36	GO:0010243	response to organonitrogen compound
0.36	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.36	GO:0055114	oxidation-reduction process
0.36	GO:0006621	protein retention in ER lumen
0.35	GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
0.35	GO:0036508	protein alpha-1,2-demannosylation
0.35	GO:0035977	protein deglycosylation involved in glycoprotein catabolic process

0.53	GO:0003756	protein disulfide isomerase activity
0.40	GO:0015037	peptide disulfide oxidoreductase activity
0.36	GO:0019153	protein-disulfide reductase (glutathione) activity
0.36	GO:0051082	unfolded protein binding
0.35	GO:0016971	flavin-linked sulfhydryl oxidase activity
0.35	GO:0031545	peptidyl-proline 4-dioxygenase activity
0.34	GO:0001026	TFIIIB-type transcription factor activity
0.34	GO:0017025	TBP-class protein binding
0.34	GO:0015035	protein disulfide oxidoreductase activity
0.34	GO:0005230	extracellular ligand-gated ion channel activity

0.49	GO:0005783	endoplasmic reticulum
0.40	GO:0043233	organelle lumen
0.39	GO:0005615	extracellular space
0.39	GO:0044446	intracellular organelle part
0.39	GO:0009986	cell surface
0.35	GO:0042470	melanosome
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.34	GO:0031301	integral component of organelle membrane
0.34	GO:0005667	transcription factor complex
0.34	GO:0005794	Golgi apparatus

0.53

EC:5.3.4.1

GO:0003756

tr|T1ED55|T1ED55_HELRO
Uncharacterized protein
Search

tr|T1ED56|T1ED56_HELRO
Uncharacterized protein
Search

tr|T1ED57|T1ED57_HELRO
Uncharacterized protein
Search

0.66	Enah/vasp like a

0.48	GO:0030036	actin cytoskeleton organization
0.46	GO:0097435	supramolecular fiber organization
0.45	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.44	GO:0046907	intracellular transport
0.40	GO:0030838	positive regulation of actin filament polymerization
0.38	GO:1904171	negative regulation of bleb assembly
0.38	GO:0007049	cell cycle
0.37	GO:0051289	protein homotetramerization
0.36	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation
0.36	GO:0030865	cortical cytoskeleton organization

0.49	GO:0003779	actin binding
0.45	GO:0004864	protein phosphatase inhibitor activity
0.44	GO:0017048	Rho GTPase binding
0.37	GO:0017124	SH3 domain binding
0.36	GO:0035091	phosphatidylinositol binding
0.35	GO:0032403	protein complex binding
0.35	GO:0008017	microtubule binding
0.34	GO:0003743	translation initiation factor activity
0.34	GO:0017111	nucleoside-triphosphatase activity
0.34	GO:0032550	purine ribonucleoside binding

0.37	GO:0031254	cell trailing edge
0.37	GO:0005622	intracellular
0.37	GO:0032154	cleavage furrow
0.35	GO:0042995	cell projection
0.35	GO:0043228	non-membrane-bounded organelle
0.35	GO:0005925	focal adhesion
0.35	GO:0099512	supramolecular fiber
0.34	GO:0071944	cell periphery
0.33	GO:0044422	organelle part
0.30	GO:0016020	membrane

0.34

EC:3.6.1.15

GO:0017111

tr|T1ED58|T1ED58_HELRO
Uncharacterized protein
Search

0.54	Aromatic-L-amino-acid decarboxylase

0.60	GO:0006520	cellular amino acid metabolic process
0.46	GO:0048148	behavioral response to cocaine
0.46	GO:0018991	oviposition
0.45	GO:0045475	locomotor rhythm
0.42	GO:0006589	octopamine biosynthetic process
0.34	GO:0007420	brain development

0.68	GO:0016831	carboxy-lyase activity
0.67	GO:0030170	pyridoxal phosphate binding

0.40	GO:0043025	neuronal cell body
0.40	GO:0030424	axon
0.32	GO:0005737	cytoplasm

0.68

EC:4.1.1

GO:0016831

tr|T1ED59|T1ED59_HELRO
Uncharacterized protein
Search

tr|T1ED60|T1ED60_HELRO
Uncharacterized protein
Search

0.77	GO:0016180	snRNA processing
0.61	GO:0043628	ncRNA 3'-end processing
0.45	GO:0006886	intracellular protein transport
0.45	GO:0016192	vesicle-mediated transport
0.44	GO:0042795	snRNA transcription by RNA polymerase II
0.38	GO:0035235	ionotropic glutamate receptor signaling pathway
0.34	GO:0055114	oxidation-reduction process

0.38	GO:0004970	ionotropic glutamate receptor activity
0.38	GO:0005515	protein binding
0.37	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.36	GO:0020037	heme binding
0.36	GO:0005506	iron ion binding

0.65	GO:0032039	integrator complex
0.48	GO:0030117	membrane coat
0.30	GO:0031224	intrinsic component of membrane

0.37

GO:0016705

tr|T1ED61|T1ED61_HELRO
Uncharacterized protein
Search

HBS1L

0.71	HBS1 like translational GTPase

0.43	GO:0006414	translational elongation
0.35	GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
0.33	GO:0055114	oxidation-reduction process
0.33	GO:0007165	signal transduction

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0003746	translation elongation factor activity
0.34	GO:0004781	sulfate adenylyltransferase (ATP) activity
0.34	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.34	GO:0005515	protein binding

0.36	GO:0070062	extracellular exosome
0.35	GO:0005622	intracellular
0.30	GO:0016020	membrane

0.34

EC:2.7.7.4

GO:0004781

tr|T1ED62|T1ED62_HELRO
Uncharacterized protein
Search

0.91	Acyl-CoA synthetase bubblegum family member 2

0.48

GO:0001676

long-chain fatty acid metabolic process

0.48	GO:0047617	acyl-CoA hydrolase activity
0.48	GO:0004467	long-chain fatty acid-CoA ligase activity

0.44	GO:0005829	cytosol
0.41	GO:0005739	mitochondrion

0.48

EC:3.1.2 EC:3.1.2.20

GO:0047617

tr|T1ED63|T1ED63_HELRO
Uncharacterized protein
Search

HECW2

0.69	Hect type E3 ubiquitin ligase

0.73	GO:0016567	protein ubiquitination
0.46	GO:0030071	regulation of mitotic metaphase/anaphase transition
0.46	GO:0006511	ubiquitin-dependent protein catabolic process
0.44	GO:0010498	proteasomal protein catabolic process

0.74	GO:0004842	ubiquitin-protein transferase activity
0.52	GO:0016874	ligase activity
0.48	GO:0061659	ubiquitin-like protein ligase activity
0.33	GO:0005515	protein binding

0.46	GO:0072686	mitotic spindle
0.37	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.52	EC:6	GO:0016874
0.74	KEGG:R03876	GO:0004842

tr|T1ED64|T1ED64_HELRO
Uncharacterized protein
Search

0.43	NADH-dependent fumarate reductase

0.53	GO:0017013	protein flavinylation
0.52	GO:0055114	oxidation-reduction process
0.52	GO:0006379	mRNA cleavage
0.51	GO:0006378	mRNA polyadenylation
0.39	GO:0071454	cellular response to anoxia
0.35	GO:0006888	ER to Golgi vesicle-mediated transport
0.34	GO:0034975	protein folding in endoplasmic reticulum
0.34	GO:0046443	FAD metabolic process
0.32	GO:0055085	transmembrane transport

0.76	GO:0000104	succinate dehydrogenase activity
0.53	GO:0016156	fumarate reductase (NADH) activity
0.33	GO:0016746	transferase activity, transferring acyl groups

0.52	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
0.36	GO:0005829	cytosol
0.35	GO:0020015	glycosome
0.33	GO:0005783	endoplasmic reticulum
0.33	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

0.76	EC:1.3.99.1	GO:0000104
0.53	KEGG:R00402	GO:0016156

tr|T1ED65|T1ED65_HELRO
Uncharacterized protein
Search

MRPL4

0.79	39S ribosomal protein L4, mitochondrial

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.38	GO:0043624	cellular protein complex disassembly

0.64	GO:0003735	structural constituent of ribosome
0.47	GO:0003743	translation initiation factor activity
0.36	GO:0005515	protein binding

0.61	GO:0005840	ribosome
0.41	GO:0005759	mitochondrial matrix
0.37	GO:0044445	cytosolic part
0.36	GO:0031966	mitochondrial membrane
0.36	GO:0019866	organelle inner membrane

tr|T1ED66|T1ED66_HELRO
Uncharacterized protein
Search

SMARCA5

0.90	Chromatin-remodeling complex ATPase chain Iswi

0.81	GO:0043044	ATP-dependent chromatin remodeling
0.74	GO:0016569	covalent chromatin modification
0.46	GO:0016584	nucleosome positioning
0.45	GO:0000183	chromatin silencing at rDNA
0.44	GO:1990823	response to leukemia inhibitory factor
0.44	GO:0006334	nucleosome assembly
0.43	GO:0003231	cardiac ventricle development
0.43	GO:0060041	retina development in camera-type eye
0.43	GO:0071345	cellular response to cytokine stimulus
0.42	GO:0045893	positive regulation of transcription, DNA-templated

0.83	GO:0031491	nucleosome binding
0.67	GO:0004386	helicase activity
0.61	GO:0016887	ATPase activity
0.55	GO:0030554	adenyl nucleotide binding
0.55	GO:0003677	DNA binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0042393	histone binding
0.34	GO:0008081	phosphoric diester hydrolase activity

0.84	GO:0016589	NURF complex
0.46	GO:0031213	RSF complex
0.45	GO:0005677	chromatin silencing complex
0.44	GO:0001650	fibrillar center
0.44	GO:0043596	nuclear replication fork
0.42	GO:0000793	condensed chromosome
0.36	GO:0016590	ACF complex
0.36	GO:0008623	CHRAC
0.35	GO:0005700	polytene chromosome
0.34	GO:0005667	transcription factor complex

0.61

GO:0016887

tr|T1ED67|T1ED67_HELRO
Uncharacterized protein
Search

0.63	Speckle type BTB/POZ protein like

0.82	GO:1901044	protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
0.76	GO:0007367	segment polarity determination
0.76	GO:0042067	establishment of ommatidial planar polarity
0.75	GO:0045879	negative regulation of smoothened signaling pathway
0.74	GO:0031648	protein destabilization
0.74	GO:0042308	negative regulation of protein import into nucleus
0.73	GO:0051865	protein autoubiquitination
0.72	GO:0046330	positive regulation of JNK cascade
0.70	GO:0030162	regulation of proteolysis
0.68	GO:0043065	positive regulation of apoptotic process

0.65	GO:0042803	protein homodimerization activity
0.56	GO:0031625	ubiquitin protein ligase binding
0.36	GO:0016491	oxidoreductase activity
0.35	GO:0003676	nucleic acid binding

0.59	GO:0005634	nucleus
0.58	GO:0019005	SCF ubiquitin ligase complex
0.46	GO:0031463	Cul3-RING ubiquitin ligase complex
0.42	GO:0000808	origin recognition complex
0.40	GO:0005737	cytoplasm
0.38	GO:0043233	organelle lumen

0.36

GO:0016491

tr|T1ED68|T1ED68_HELRO
Uncharacterized protein
Search

CUL3

0.72	Putative e3 ubiquitin ligase cullin 2 component

0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.42	GO:0044346	fibroblast apoptotic process
0.41	GO:0072576	liver morphogenesis
0.41	GO:0001831	trophectodermal cellular morphogenesis
0.41	GO:0040016	embryonic cleavage
0.41	GO:0071218	cellular response to misfolded protein
0.41	GO:0043149	stress fiber assembly
0.40	GO:0035024	negative regulation of Rho protein signal transduction
0.40	GO:0000209	protein polyubiquitination
0.40	GO:0017145	stem cell division

0.79	GO:0031625	ubiquitin protein ligase binding
0.41	GO:0031208	POZ domain binding
0.40	GO:0004842	ubiquitin-protein transferase activity
0.40	GO:0005112	Notch binding
0.40	GO:0030332	cyclin binding
0.38	GO:0061659	ubiquitin-like protein ligase activity
0.38	GO:0042803	protein homodimerization activity
0.38	GO:0046982	protein heterodimerization activity
0.35	GO:0016874	ligase activity

0.69	GO:0031461	cullin-RING ubiquitin ligase complex
0.41	GO:0005827	polar microtubule
0.38	GO:0000139	Golgi membrane
0.36	GO:0005634	nucleus
0.35	GO:0035324	female germline ring canal
0.32	GO:0070062	extracellular exosome
0.32	GO:0005829	cytosol
0.32	GO:0070013	intracellular organelle lumen
0.30	GO:0016021	integral component of membrane

0.35	EC:6	GO:0016874
0.40	KEGG:R03876	GO:0004842

tr|T1ED69|T1ED69_HELRO
Uncharacterized protein
Search

0.78	Golgi pH regulator B

0.50	GO:0043588	skin development
0.49	GO:0051452	intracellular pH reduction
0.43	GO:0098656	anion transmembrane transport
0.40	GO:0034765	regulation of ion transmembrane transport
0.38	GO:0015031	protein transport
0.36	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.34	GO:0007154	cell communication
0.34	GO:0023052	signaling
0.33	GO:0051716	cellular response to stimulus
0.30	GO:0008152	metabolic process

0.46	GO:0008308	voltage-gated anion channel activity
0.34	GO:0004871	signal transducer activity
0.30	GO:0003824	catalytic activity

0.47	GO:0032580	Golgi cisterna membrane
0.38	GO:0030660	Golgi-associated vesicle membrane
0.34	GO:0005922	connexin complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1ED70|T1ED70_HELRO
Uncharacterized protein
Search

0.59	Zinc finger C4H2 domain-containing protein (Fragment)

0.82	GO:0045666	positive regulation of neuron differentiation
0.64	GO:0021522	spinal cord motor neuron differentiation
0.63	GO:0007528	neuromuscular junction development
0.61	GO:0048665	neuron fate specification
0.56	GO:0048666	neuron development

0.37	GO:0046872	metal ion binding
0.36	GO:0005515	protein binding

0.72	GO:0045211	postsynaptic membrane
0.61	GO:0005634	nucleus
0.46	GO:0005737	cytoplasm
0.43	GO:0030054	cell junction
0.30	GO:0031224	intrinsic component of membrane

tr|T1ED71|T1ED71_HELRO
Uncharacterized protein
Search

TBRG1

0.75	Transforming growth factor beta regulator

0.61	GO:1990173	protein localization to nucleoplasm
0.56	GO:0007050	cell cycle arrest
0.54	GO:0050821	protein stabilization
0.54	GO:0008285	negative regulation of cell proliferation
0.47	GO:0006260	DNA replication
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0010468	regulation of gene expression
0.34	GO:0035385	Roundabout signaling pathway

0.33

GO:0005515

protein binding

0.61	GO:0005634	nucleus
0.33	GO:0030424	axon

tr|T1ED72|T1ED72_HELRO
Uncharacterized protein
Search

MAP2K4

0.90	Dual specificity mitogen-activated protein kinase kinase 4

0.63	GO:0006468	protein phosphorylation
0.53	GO:2000672	negative regulation of motor neuron apoptotic process
0.52	GO:0071260	cellular response to mechanical stimulus
0.52	GO:0034393	positive regulation of smooth muscle cell apoptotic process
0.48	GO:0031098	stress-activated protein kinase signaling cascade
0.48	GO:0009611	response to wounding
0.47	GO:0032147	activation of protein kinase activity
0.45	GO:0043507	positive regulation of JUN kinase activity
0.43	GO:0007346	regulation of mitotic cell cycle
0.42	GO:0007275	multicellular organism development

0.67	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0004708	MAP kinase kinase activity
0.40	GO:0031435	mitogen-activated protein kinase kinase kinase binding
0.36	GO:0004713	protein tyrosine kinase activity
0.36	GO:0005057	signal transducer activity, downstream of receptor
0.33	GO:0003723	RNA binding
0.32	GO:0016787	hydrolase activity

0.43	GO:0030424	axon
0.40	GO:0032839	dendrite cytoplasm
0.39	GO:0043204	perikaryon
0.37	GO:0005829	cytosol
0.35	GO:0005634	nucleus

0.67

GO:0004674

tr|T1ED73|T1ED73_HELRO
Uncharacterized protein
Search

0.54	Putative the phosphoinositide binding phox similarity domain of sorting nexin 3

0.46	GO:0061357	positive regulation of Wnt protein secretion
0.44	GO:0032456	endocytic recycling
0.44	GO:0035220	wing disc development
0.43	GO:0016050	vesicle organization
0.43	GO:0050821	protein stabilization
0.40	GO:0006897	endocytosis
0.33	GO:0008213	protein alkylation
0.33	GO:0043414	macromolecule methylation
0.33	GO:0006508	proteolysis

0.76	GO:0035091	phosphatidylinositol binding
0.33	GO:0070001	aspartic-type peptidase activity
0.33	GO:0004175	endopeptidase activity
0.33	GO:0008168	methyltransferase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.47	GO:0005768	endosome
0.43	GO:0030904	retromer complex
0.42	GO:0019898	extrinsic component of membrane
0.30	GO:0016021	integral component of membrane

0.33

GO:0008168

tr|T1ED74|T1ED74_HELRO
Uncharacterized protein
Search

ETFB

0.44	Electron-transfer-flavoprotein beta polypeptide

0.61	GO:0022900	electron transport chain
0.41	GO:0007406	negative regulation of neuroblast proliferation
0.38	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
0.36	GO:0000338	protein deneddylation
0.34	GO:0006119	oxidative phosphorylation
0.34	GO:0007034	vacuolar transport

0.62

GO:0009055

electron transfer activity

0.38	GO:0005829	cytosol
0.37	GO:0005759	mitochondrial matrix
0.37	GO:0045251	electron transfer flavoprotein complex
0.36	GO:0008180	COP9 signalosome
0.35	GO:0098798	mitochondrial protein complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1ED75|T1ED75_HELRO
Uncharacterized protein
Search

0.92	Gamma-aminobutyric acid type B receptor subunit 1

0.68	GO:0007186	G-protein coupled receptor signaling pathway
0.40	GO:0035094	response to nicotine
0.38	GO:0030534	adult behavior
0.37	GO:0007194	negative regulation of adenylate cyclase activity
0.36	GO:0014053	negative regulation of gamma-aminobutyric acid secretion
0.35	GO:0033602	negative regulation of dopamine secretion
0.35	GO:0032811	negative regulation of epinephrine secretion
0.35	GO:0014049	positive regulation of glutamate secretion
0.35	GO:0060124	positive regulation of growth hormone secretion
0.35	GO:0050805	negative regulation of synaptic transmission

0.81	GO:0004965	G-protein coupled GABA receptor activity
0.35	GO:1990430	extracellular matrix protein binding
0.34	GO:0046982	protein heterodimerization activity
0.34	GO:0008134	transcription factor binding

0.52	GO:0038039	G-protein coupled receptor heterodimeric complex
0.48	GO:0042734	presynaptic membrane
0.46	GO:0045211	postsynaptic membrane
0.37	GO:0030425	dendrite
0.36	GO:0030054	cell junction
0.36	GO:0005737	cytoplasm
0.35	GO:1902710	GABA receptor complex
0.35	GO:0030673	axolemma
0.35	GO:0043204	perikaryon
0.35	GO:0044309	neuron spine

tr|T1ED76|T1ED76_HELRO
Uncharacterized protein
Search

AKR1A1

0.37	Alcohol dehydrogenase

0.53	GO:0055114	oxidation-reduction process
0.49	GO:0042840	D-glucuronate catabolic process
0.48	GO:0019853	L-ascorbic acid biosynthetic process
0.44	GO:0046185	aldehyde catabolic process
0.33	GO:0006357	regulation of transcription by RNA polymerase II
0.32	GO:0055085	transmembrane transport
0.32	GO:0006351	transcription, DNA-templated

0.54	GO:0016491	oxidoreductase activity
0.33	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.32	GO:0008270	zinc ion binding
0.32	GO:0022857	transmembrane transporter activity
0.32	GO:0003677	DNA binding
0.32	GO:1901265	nucleoside phosphate binding
0.32	GO:0036094	small molecule binding

0.45	GO:0016324	apical plasma membrane
0.41	GO:0005829	cytosol
0.32	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.54

GO:0016491

tr|T1ED77|T1ED77_HELRO
Uncharacterized protein
Search

DNM1

0.78	Dynamin 1 short form

0.69	GO:0006897	endocytosis
0.51	GO:0070142	synaptic vesicle budding
0.50	GO:0051932	synaptic transmission, GABAergic
0.49	GO:0036465	synaptic vesicle recycling
0.48	GO:0007032	endosome organization
0.48	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission
0.48	GO:0008344	adult locomotory behavior
0.47	GO:0007605	sensory perception of sound
0.46	GO:1901998	toxin transport
0.46	GO:0051262	protein tetramerization

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0019901	protein kinase binding
0.45	GO:0042802	identical protein binding
0.43	GO:0008017	microtubule binding
0.43	GO:0046983	protein dimerization activity
0.39	GO:0031749	D2 dopamine receptor binding

0.49	GO:0001917	photoreceptor inner segment
0.48	GO:0005874	microtubule
0.47	GO:0043209	myelin sheath
0.45	GO:0045202	synapse
0.45	GO:0030117	membrane coat
0.44	GO:0005654	nucleoplasm
0.39	GO:0031966	mitochondrial membrane
0.39	GO:0043196	varicosity
0.38	GO:0099503	secretory vesicle
0.37	GO:0030133	transport vesicle

tr|T1ED78|T1ED78_HELRO
Uncharacterized protein
Search

tr|T1ED79|T1ED79_HELRO
Uncharacterized protein
Search

ARL3

0.92	ADP ribosylation factor like GTPase 3

0.53	GO:0042461	photoreceptor cell development
0.52	GO:0000281	mitotic cytokinesis
0.52	GO:0001822	kidney development
0.51	GO:0060271	cilium assembly
0.51	GO:0042073	intraciliary transport
0.51	GO:0007224	smoothened signaling pathway
0.50	GO:0006892	post-Golgi vesicle-mediated transport
0.50	GO:0007264	small GTPase mediated signal transduction

0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0008017	microtubule binding
0.46	GO:0003924	GTPase activity
0.34	GO:0046872	metal ion binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0008144	drug binding

0.54	GO:0032391	photoreceptor connecting cilium
0.53	GO:0005881	cytoplasmic microtubule
0.53	GO:0030496	midbody
0.52	GO:0005876	spindle microtubule
0.51	GO:0005813	centrosome
0.50	GO:0036064	ciliary basal body
0.50	GO:0005930	axoneme
0.48	GO:0005794	Golgi apparatus
0.44	GO:0005634	nucleus
0.39	GO:0098588	bounding membrane of organelle

tr|T1ED80|T1ED80_HELRO
Uncharacterized protein
Search

0.37	AMP-dependent synthetase and ligase

0.43

GO:0001676

long-chain fatty acid metabolic process

0.55

GO:0016874

ligase activity

0.30

GO:0044425

membrane part

0.55

GO:0016874

tr|T1ED81|T1ED81_HELRO
Uncharacterized protein
Search

0.70	Niemann-Pick type C-1a, isoform A

0.73	GO:0006869	lipid transport
0.44	GO:0045456	ecdysteroid biosynthetic process
0.43	GO:0007291	sperm individualization
0.43	GO:0032374	regulation of cholesterol transport
0.43	GO:0007591	molting cycle, chitin-based cuticle
0.41	GO:0016125	sterol metabolic process
0.38	GO:0006898	receptor-mediated endocytosis
0.36	GO:0055113	epiboly involved in gastrulation with mouth forming second
0.36	GO:0035855	megakaryocyte development
0.35	GO:0001666	response to hypoxia

0.75	GO:0005319	lipid transporter activity
0.39	GO:0005044	scavenger receptor activity
0.34	GO:0004862	cAMP-dependent protein kinase inhibitor activity

0.30

GO:0016020

membrane

tr|T1ED82|T1ED82_HELRO
Uncharacterized protein
Search

LSM1

0.93	LSM1 homolog, mRNA degradation associated

0.78	GO:0000956	nuclear-transcribed mRNA catabolic process
0.54	GO:0008334	histone mRNA metabolic process
0.52	GO:0019827	stem cell population maintenance
0.52	GO:0045665	negative regulation of neuron differentiation
0.44	GO:0033962	cytoplasmic mRNA processing body assembly
0.37	GO:0008380	RNA splicing
0.36	GO:0006397	mRNA processing

0.49	GO:0000339	RNA cap binding
0.41	GO:0003729	mRNA binding
0.39	GO:0036002	pre-mRNA binding
0.39	GO:0003682	chromatin binding
0.34	GO:0005515	protein binding

0.59	GO:0030529	intracellular ribonucleoprotein complex
0.50	GO:0005845	mRNA cap binding complex
0.50	GO:1990726	Lsm1-7-Pat1 complex
0.45	GO:0043232	intracellular non-membrane-bounded organelle
0.44	GO:0005634	nucleus
0.42	GO:0044444	cytoplasmic part
0.41	GO:0019013	viral nucleocapsid
0.39	GO:0043025	neuronal cell body
0.39	GO:0030425	dendrite
0.39	GO:0030424	axon

tr|T1ED83|T1ED83_HELRO
Uncharacterized protein
Search

HSPA13

0.80	Testis secretory sperm-binding protein Li 199a

0.35	GO:0035966	response to topologically incorrect protein
0.34	GO:0032324	molybdopterin cofactor biosynthetic process
0.34	GO:0006777	Mo-molybdopterin cofactor biosynthetic process
0.33	GO:0046854	phosphatidylinositol phosphorylation
0.32	GO:1902358	sulfate transmembrane transport

0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding
0.33	GO:0008271	secondary active sulfate transmembrane transporter activity

0.37	GO:0005783	endoplasmic reticulum
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

tr|T1ED84|T1ED84_HELRO
Microtubule-associated protein
Search

0.39	Microtubule-associated protein

0.44	GO:0031175	neuron projection development
0.44	GO:0000226	microtubule cytoskeleton organization

0.74	GO:0015631	tubulin binding
0.36	GO:0005509	calcium ion binding

0.73	GO:0005874	microtubule
0.49	GO:0005737	cytoplasm
0.44	GO:0043005	neuron projection
0.44	GO:0005875	microtubule associated complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1ED85|T1ED85_HELRO
Uncharacterized protein
Search

MMAA

0.95	Methylmalonic aciduria type A protein, mitochondrial

0.36	GO:0009236	cobalamin biosynthetic process
0.35	GO:0019626	short-chain fatty acid catabolic process

0.65	GO:0003924	GTPase activity
0.63	GO:0032550	purine ribonucleoside binding
0.63	GO:0019001	guanyl nucleotide binding
0.53	GO:0042803	protein homodimerization activity
0.52	GO:0032555	purine ribonucleotide binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding

0.35	GO:0005739	mitochondrion
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

tr|T1ED86|T1ED86_HELRO
Uncharacterized protein
Search

0.53	GO:0055114	oxidation-reduction process
0.37	GO:0019373	epoxygenase P450 pathway

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.65	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.38	GO:0004796	thromboxane-A synthase activity

0.40	GO:0005789	endoplasmic reticulum membrane
0.32	GO:0031090	organelle membrane
0.30	GO:0031224	intrinsic component of membrane

0.68	EC:1.14	GO:0016705
0.38	KEGG:R02268	GO:0004796

tr|T1ED87|T1ED87_HELRO
Uncharacterized protein
Search

0.67	General transcription factor IIH subunit

0.72	GO:0006289	nucleotide-excision repair
0.57	GO:0006351	transcription, DNA-templated
0.43	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain
0.41	GO:0045944	positive regulation of transcription by RNA polymerase II
0.34	GO:1990830	cellular response to leukemia inhibitory factor
0.33	GO:0019752	carboxylic acid metabolic process
0.33	GO:0005975	carbohydrate metabolic process
0.32	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
0.32	GO:0031334	positive regulation of protein complex assembly
0.32	GO:0065004	protein-DNA complex assembly

0.46	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.42	GO:0008094	DNA-dependent ATPase activity
0.34	GO:0004459	L-lactate dehydrogenase activity
0.34	GO:0003682	chromatin binding
0.33	GO:0005515	protein binding
0.32	GO:0004828	serine-tRNA ligase activity
0.31	GO:0030554	adenyl nucleotide binding
0.31	GO:0032555	purine ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.80	GO:0000439	core TFIIH complex
0.46	GO:0005675	holo TFIIH complex
0.40	GO:0005680	anaphase-promoting complex
0.32	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.46

EC:2.7.11.23

GO:0008353

tr|T1ED88|T1ED88_HELRO
Uncharacterized protein
Search

DCTN1

0.47	Dynactin subunit 1

0.82	GO:0010970	transport along microtubule
0.44	GO:0060219	camera-type eye photoreceptor cell differentiation
0.40	GO:0051656	establishment of organelle localization
0.40	GO:0045176	apical protein localization
0.40	GO:0010842	retina layer formation
0.39	GO:0051647	nucleus localization
0.39	GO:0090063	positive regulation of microtubule nucleation
0.39	GO:0048663	neuron fate commitment
0.39	GO:0051081	nuclear envelope disassembly
0.38	GO:0010457	centriole-centriole cohesion

0.84	GO:0070840	dynein complex binding
0.42	GO:0004386	helicase activity
0.41	GO:0008270	zinc ion binding
0.38	GO:0032559	adenyl ribonucleotide binding
0.38	GO:0008144	drug binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0003676	nucleic acid binding
0.37	GO:0019901	protein kinase binding
0.36	GO:0008017	microtubule binding
0.36	GO:0015002	heme-copper terminal oxidase activity

0.82	GO:0005869	dynactin complex
0.39	GO:0120103	centriolar subdistal appendage
0.38	GO:0035371	microtubule plus-end
0.38	GO:0099738	cell cortex region
0.38	GO:0005814	centriole
0.37	GO:0030904	retromer complex
0.37	GO:0031252	cell leading edge
0.37	GO:0000922	spindle pole
0.37	GO:0031967	organelle envelope
0.37	GO:0045111	intermediate filament cytoskeleton

0.36

EC:1.9.3

GO:0016676

tr|T1ED89|T1ED89_HELRO
Uncharacterized protein
Search

tr|T1ED90|T1ED90_HELRO
Uncharacterized protein
Search

DIEXF

0.90	Digestive organ expansion factor

0.45	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.44	GO:0090594	inflammatory response to wounding
0.44	GO:0031017	exocrine pancreas development
0.43	GO:0031648	protein destabilization
0.43	GO:0035265	organ growth
0.43	GO:0048546	digestive tract morphogenesis
0.39	GO:0030163	protein catabolic process
0.31	GO:0055085	transmembrane transport

0.47	GO:0034511	U3 snoRNA binding
0.40	GO:0019843	rRNA binding
0.33	GO:0005515	protein binding
0.32	GO:0015293	symporter activity

0.57	GO:0005634	nucleus
0.47	GO:0031974	membrane-enclosed lumen
0.44	GO:0032040	small-subunit processome
0.43	GO:0043232	intracellular non-membrane-bounded organelle
0.43	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

tr|T1ED91|T1ED91_HELRO
Uncharacterized protein
Search

EXOSC1

0.72	Exosomal 3'-5' exoribonuclease complex subunit ski4

0.38	GO:0060255	regulation of macromolecule metabolic process
0.34	GO:0033014	tetrapyrrole biosynthetic process
0.33	GO:0006520	cellular amino acid metabolic process

0.59	GO:0003723	RNA binding
0.35	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity
0.35	GO:0070546	L-phenylalanine aminotransferase activity
0.34	GO:0004852	uroporphyrinogen-III synthase activity
0.34	GO:0030170	pyridoxal phosphate binding

0.79	GO:0000178	exosome (RNase complex)
0.46	GO:0035327	transcriptionally active chromatin
0.45	GO:0031981	nuclear lumen
0.37	GO:0005737	cytoplasm

0.35	EC:2.6.1.1	GO:0004069
0.35	KEGG:R00355	GO:0004069

tr|T1ED92|T1ED92_HELRO
Uncharacterized protein
Search

ALDH8A1

0.38	NAD-dependent aldehyde dehydrogenase

0.53	GO:0055114	oxidation-reduction process
0.51	GO:0042904	9-cis-retinoic acid biosynthetic process
0.51	GO:0042574	retinal metabolic process
0.42	GO:0001889	liver development
0.35	GO:0050790	regulation of catalytic activity

0.69	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.36	GO:0030695	GTPase regulator activity
0.34	GO:0003924	GTPase activity
0.34	GO:0032550	purine ribonucleoside binding
0.34	GO:0019001	guanyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.36	GO:0070062	extracellular exosome
0.36	GO:0005622	intracellular
0.30	GO:0016020	membrane

0.69

GO:0016620

tr|T1ED93|T1ED93_HELRO
Uncharacterized protein
Search

EFHC1

0.95	EF-hand domain-containing protein 1

0.46	GO:0021795	cerebral cortex cell migration
0.45	GO:0007052	mitotic spindle organization
0.44	GO:0000281	mitotic cytokinesis
0.44	GO:0051302	regulation of cell division
0.40	GO:1990830	cellular response to leukemia inhibitory factor
0.37	GO:0051124	synaptic growth at neuromuscular junction
0.36	GO:0048814	regulation of dendrite morphogenesis
0.33	GO:0015074	DNA integration

0.68	GO:0005509	calcium ion binding
0.46	GO:0043014	alpha-tubulin binding

0.44	GO:0072686	mitotic spindle
0.44	GO:0000922	spindle pole
0.44	GO:0005813	centrosome
0.43	GO:0031514	motile cilium
0.36	GO:0043195	terminal bouton
0.36	GO:0043025	neuronal cell body
0.36	GO:0030425	dendrite
0.35	GO:0005874	microtubule
0.30	GO:0031224	intrinsic component of membrane

tr|T1ED94|T1ED94_HELRO
Uncharacterized protein
Search

INSIG2

0.93	Insulin-induced gene protein (Fragment)

0.82	GO:0008203	cholesterol metabolic process
0.57	GO:0060363	cranial suture morphogenesis
0.56	GO:0042474	middle ear morphogenesis
0.56	GO:0010894	negative regulation of steroid biosynthetic process
0.56	GO:0006991	response to sterol depletion
0.55	GO:0006984	ER-nucleus signaling pathway
0.55	GO:0060021	palate development
0.54	GO:0045717	negative regulation of fatty acid biosynthetic process
0.54	GO:0042472	inner ear morphogenesis
0.53	GO:0006641	triglyceride metabolic process

0.37

GO:0008134

transcription factor binding

0.65	GO:0005789	endoplasmic reticulum membrane
0.44	GO:0098796	membrane protein complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1ED95|T1ED95_HELRO
Uncharacterized protein
Search

0.36

GO:0034968

histone lysine methylation

0.55	GO:0016853	isomerase activity
0.39	GO:0016787	hydrolase activity
0.39	GO:0003723	RNA binding
0.36	GO:0018024	histone-lysine N-methyltransferase activity

0.34	GO:0005634	nucleus
0.30	GO:0044425	membrane part

0.55

GO:0016853

tr|T1ED96|T1ED96_HELRO
Uncharacterized protein
Search

0.89	U3 small nucleolar RNA-interacting protein, putative

0.52	GO:0006364	rRNA processing
0.41	GO:0006468	protein phosphorylation
0.40	GO:0007165	signal transduction
0.37	GO:0006508	proteolysis
0.34	GO:0055114	oxidation-reduction process

0.70	GO:0030515	snoRNA binding
0.51	GO:0016905	myosin heavy chain kinase activity
0.41	GO:0102294	cholesterol dehydrogenase activity
0.39	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
0.39	GO:0004222	metalloendopeptidase activity
0.36	GO:0016853	isomerase activity
0.36	GO:0046872	metal ion binding

0.64	GO:0032040	small-subunit processome
0.53	GO:0031428	box C/D snoRNP complex
0.48	GO:0019013	viral nucleocapsid
0.30	GO:0016020	membrane

0.51

GO:0016905

tr|T1ED97|T1ED97_HELRO
Uncharacterized protein
Search

0.74	GO:0007018	microtubule-based movement
0.39	GO:0030705	cytoskeleton-dependent intracellular transport
0.39	GO:0051656	establishment of organelle localization
0.38	GO:0051648	vesicle localization
0.36	GO:0045022	early endosome to late endosome transport
0.36	GO:0001919	regulation of receptor recycling
0.36	GO:0007173	epidermal growth factor receptor signaling pathway
0.36	GO:0071346	cellular response to interferon-gamma
0.36	GO:0006895	Golgi to endosome transport
0.36	GO:0007492	endoderm development

0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0016887	ATPase activity
0.39	GO:0035091	phosphatidylinositol binding
0.35	GO:0017137	Rab GTPase binding
0.34	GO:0061711	N(6)-L-threonylcarbamoyladenine synthase
0.34	GO:0003873	6-phosphofructo-2-kinase activity

0.56	GO:0015630	microtubule cytoskeleton
0.56	GO:0099513	polymeric cytoskeletal fiber
0.41	GO:0043234	protein complex
0.39	GO:0097730	non-motile cilium
0.38	GO:0043025	neuronal cell body
0.38	GO:0030425	dendrite
0.38	GO:0030424	axon
0.35	GO:0045335	phagocytic vesicle
0.35	GO:0005769	early endosome
0.34	GO:0031966	mitochondrial membrane

0.41	EC:3.6.1.3	GO:0016887
0.34	KEGG:R02732	GO:0003873

tr|T1ED98|T1ED98_HELRO
Uncharacterized protein
Search

DNAJC10

0.82	LOW QUALITY PROTEIN: dnaJ homolog subfamily C member 10

0.76	GO:0034975	protein folding in endoplasmic reticulum
0.68	GO:0045454	cell redox homeostasis
0.55	GO:0030433	ubiquitin-dependent ERAD pathway
0.53	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
0.48	GO:0055114	oxidation-reduction process
0.48	GO:0001933	negative regulation of protein phosphorylation
0.46	GO:0032781	positive regulation of ATPase activity
0.33	GO:0007018	microtubule-based movement

0.63	GO:0015036	disulfide oxidoreductase activity
0.53	GO:0030544	Hsp70 protein binding
0.53	GO:0051787	misfolded protein binding
0.52	GO:0051117	ATPase binding
0.50	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
0.49	GO:0051087	chaperone binding
0.46	GO:0001671	ATPase activator activity
0.33	GO:0003777	microtubule motor activity
0.33	GO:0008017	microtubule binding
0.32	GO:0016853	isomerase activity

0.63	GO:0005783	endoplasmic reticulum
0.48	GO:0043233	organelle lumen
0.43	GO:0044446	intracellular organelle part
0.42	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.50

EC:1.8.4

GO:0016671

tr|T1ED99|T1ED99_HELRO
DNA-directed RNA polymerase subunit beta
Search

0.41	DNA-directed RNA polymerase subunit beta

0.58	GO:0006351	transcription, DNA-templated
0.34	GO:0035019	somatic stem cell population maintenance
0.34	GO:0060964	regulation of gene silencing by miRNA
0.34	GO:0008543	fibroblast growth factor receptor signaling pathway
0.34	GO:0016073	snRNA metabolic process
0.34	GO:0050434	positive regulation of viral transcription
0.34	GO:0006283	transcription-coupled nucleotide-excision repair
0.34	GO:0000398	mRNA splicing, via spliceosome
0.34	GO:0006370	7-methylguanosine mRNA capping
0.34	GO:0006801	superoxide metabolic process

0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.65	GO:0001882	nucleoside binding
0.55	GO:0003677	DNA binding
0.42	GO:0003682	chromatin binding
0.34	GO:0005515	protein binding
0.33	GO:0046872	metal ion binding
0.32	GO:0003723	RNA binding

0.46	GO:0005665	DNA-directed RNA polymerase II, core complex
0.43	GO:0000784	nuclear chromosome, telomeric region
0.30	GO:0016020	membrane

0.70

GO:0003899

tr|T1EDA0|T1EDA0_HELRO
Uncharacterized protein
Search

tr|T1EDA1|T1EDA1_HELRO
Uncharacterized protein
Search

0.63	GO:0006468	protein phosphorylation
0.45	GO:0006624	vacuolar protein processing
0.45	GO:0032889	regulation of vacuole fusion, non-autophagic
0.34	GO:0006511	ubiquitin-dependent protein catabolic process
0.33	GO:0040007	growth

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0031625	ubiquitin protein ligase binding
0.33	GO:0008531	riboflavin kinase activity

0.42	GO:0005773	vacuole
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.33	EC:2.7.1.26	GO:0008531
0.33	KEGG:R00549	GO:0008531

tr|T1EDA2|T1EDA2_HELRO
Uncharacterized protein
Search

0.60	PDX1 C-terminal inhibiting factor 1

0.82

GO:0010923

negative regulation of phosphatase activity

0.85	GO:0045171	intercellular bridge
0.71	GO:0015630	microtubule cytoskeleton
0.70	GO:0005654	nucleoplasm

tr|T1EDA3|T1EDA3_HELRO
Uncharacterized protein
Search

0.58	Tyrosine-protein phosphatase Lar (Fragment)

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.37	GO:0050773	regulation of dendrite development
0.37	GO:0010769	regulation of cell morphogenesis involved in differentiation
0.37	GO:0034164	negative regulation of toll-like receptor 9 signaling pathway
0.37	GO:0010975	regulation of neuron projection development
0.37	GO:0032687	negative regulation of interferon-alpha production
0.37	GO:0090557	establishment of endothelial intestinal barrier
0.37	GO:0032688	negative regulation of interferon-beta production
0.37	GO:0022038	corpus callosum development
0.36	GO:0021766	hippocampus development

0.75	GO:0004725	protein tyrosine phosphatase activity
0.37	GO:0035374	chondroitin sulfate binding
0.36	GO:0050254	rhodopsin kinase activity
0.36	GO:0016162	cellulose 1,4-beta-cellobiosidase activity
0.36	GO:0008201	heparin binding
0.35	GO:0019198	transmembrane receptor protein phosphatase activity
0.34	GO:0050839	cell adhesion molecule binding
0.34	GO:0005102	receptor binding

0.34	GO:0070062	extracellular exosome
0.34	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.75

GO:0004725

tr|T1EDA4|T1EDA4_HELRO
Uncharacterized protein
Search

0.37	GO:0016203	muscle attachment
0.37	GO:0007525	somatic muscle development
0.36	GO:0048741	skeletal muscle fiber development
0.36	GO:0045214	sarcomere organization
0.36	GO:0061053	somite development

0.63	GO:0008270	zinc ion binding
0.55	GO:0003779	actin binding
0.47	GO:0002162	dystroglycan binding

0.41	GO:0045211	postsynaptic membrane
0.40	GO:0030054	cell junction
0.39	GO:0005856	cytoskeleton
0.36	GO:0042383	sarcolemma
0.36	GO:0016010	dystrophin-associated glycoprotein complex
0.34	GO:0005737	cytoplasm

tr|T1EDA5|T1EDA5_HELRO
Uncharacterized protein
Search

0.52	Mitogen-activated protein kinase kinase kinase 2

0.62	GO:0006468	protein phosphorylation
0.55	GO:0071864	positive regulation of cell proliferation in bone marrow
0.55	GO:2000773	negative regulation of cellular senescence
0.54	GO:1900745	positive regulation of p38MAPK cascade
0.54	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis
0.53	GO:0072359	circulatory system development
0.52	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.45	GO:0031098	stress-activated protein kinase signaling cascade
0.45	GO:0032147	activation of protein kinase activity
0.43	GO:0007346	regulation of mitotic cell cycle

0.63	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0019901	protein kinase binding
0.36	GO:0005057	signal transducer activity, downstream of receptor
0.33	GO:0046872	metal ion binding

0.38	GO:0005829	cytosol
0.37	GO:0005654	nucleoplasm

tr|T1EDA6|T1EDA6_HELRO
Uncharacterized protein
Search

0.92	TAR RNA-binding protein 2

0.84	GO:0030422	production of siRNA involved in RNA interference
0.73	GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA
0.71	GO:0031054	pre-miRNA processing
0.65	GO:0046782	regulation of viral transcription
0.63	GO:0030423	targeting of mRNA for destruction involved in RNA interference
0.58	GO:0043085	positive regulation of catalytic activity
0.48	GO:0050689	negative regulation of defense response to virus by host
0.47	GO:0035087	siRNA loading onto RISC involved in RNA interference
0.46	GO:0045070	positive regulation of viral genome replication
0.45	GO:0007281	germ cell development

0.75	GO:0003725	double-stranded RNA binding
0.72	GO:0035197	siRNA binding
0.61	GO:0035198	miRNA binding
0.59	GO:0008047	enzyme activator activity
0.55	GO:0042803	protein homodimerization activity
0.45	GO:0047485	protein N-terminus binding
0.45	GO:0070883	pre-miRNA binding
0.42	GO:0019899	enzyme binding
0.38	GO:0016301	kinase activity
0.38	GO:0003730	mRNA 3'-UTR binding

0.69	GO:0016442	RISC complex
0.49	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0070578	RISC-loading complex
0.48	GO:0035068	micro-ribonucleoprotein complex
0.43	GO:0016604	nuclear body
0.39	GO:0071212	subsynaptic reticulum
0.39	GO:0045180	basal cortex
0.38	GO:0045179	apical cortex
0.38	GO:0009925	basal plasma membrane
0.38	GO:0060293	germ plasm

0.34	EC:3.1.26.3	GO:0004525
0.32	KEGG:R00253	GO:0004356

tr|T1EDA7|T1EDA7_HELRO
Uncharacterized protein
Search

SYVN1

0.79	Synovial apoptosis inhibitor 1, synoviolin

0.82	GO:0030433	ubiquitin-dependent ERAD pathway
0.72	GO:0016567	protein ubiquitination
0.54	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.53	GO:0018279	protein N-linked glycosylation via asparagine
0.53	GO:1903513	endoplasmic reticulum to cytosol transport
0.52	GO:0032527	protein exit from endoplasmic reticulum
0.50	GO:0050821	protein stabilization
0.47	GO:0030968	endoplasmic reticulum unfolded protein response
0.37	GO:0001701	in utero embryonic development
0.36	GO:0035264	multicellular organism growth

0.76	GO:0061630	ubiquitin protein ligase activity
0.57	GO:1990381	ubiquitin-specific protease binding
0.52	GO:0051117	ATPase binding
0.50	GO:0016874	ligase activity
0.49	GO:0051087	chaperone binding
0.48	GO:0051082	unfolded protein binding
0.35	GO:0005484	SNAP receptor activity
0.35	GO:0046872	metal ion binding
0.35	GO:0033613	activating transcription factor binding

0.85	GO:0000836	Hrd1p ubiquitin ligase complex
0.56	GO:0036513	Derlin-1 retrotranslocation complex
0.53	GO:0005790	smooth endoplasmic reticulum
0.49	GO:0044322	endoplasmic reticulum quality control compartment
0.45	GO:0005654	nucleoplasm
0.34	GO:0030176	integral component of endoplasmic reticulum membrane

0.50

GO:0016874

tr|T1EDA8|T1EDA8_HELRO
Uncharacterized protein
Search

0.55	Parafibromin

0.81	GO:0006368	transcription elongation from RNA polymerase II promoter
0.74	GO:0016570	histone modification
0.51	GO:0030177	positive regulation of Wnt signaling pathway
0.50	GO:0045944	positive regulation of transcription by RNA polymerase II
0.49	GO:0034243	regulation of transcription elongation from RNA polymerase II promoter
0.47	GO:0008407	chaeta morphogenesis
0.47	GO:0032786	positive regulation of DNA-templated transcription, elongation
0.47	GO:0008586	imaginal disc-derived wing vein morphogenesis
0.47	GO:0008587	imaginal disc-derived wing margin morphogenesis
0.47	GO:0031124	mRNA 3'-end processing

0.49	GO:0000993	RNA polymerase II core binding
0.43	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding
0.42	GO:0008134	transcription factor binding
0.36	GO:0008495	protoheme IX farnesyltransferase activity

0.82	GO:0016593	Cdc73/Paf1 complex
0.43	GO:0005667	transcription factor complex
0.40	GO:0005829	cytosol
0.34	GO:0000784	nuclear chromosome, telomeric region
0.30	GO:0016020	membrane

0.36

EC:2.5.1

GO:0008495

tr|T1EDA9|T1EDA9_HELRO
Kynurenine 3-monooxygenase
Search

0.61	Kynurenine 3-monooxygenase

0.73	GO:0034354	'de novo' NAD biosynthetic process from tryptophan
0.73	GO:0043420	anthranilate metabolic process
0.72	GO:0019805	quinolinate biosynthetic process
0.71	GO:0006569	tryptophan catabolic process
0.52	GO:0055114	oxidation-reduction process
0.39	GO:0070189	kynurenine metabolic process
0.38	GO:0044550	secondary metabolite biosynthetic process
0.33	GO:0045454	cell redox homeostasis
0.33	GO:0006561	proline biosynthetic process
0.32	GO:0016310	phosphorylation

0.80	GO:0004502	kynurenine 3-monooxygenase activity
0.73	GO:0071949	FAD binding
0.41	GO:0016174	NAD(P)H oxidase activity
0.34	GO:0004349	glutamate 5-kinase activity
0.32	GO:0003723	RNA binding

0.53	GO:0005739	mitochondrion
0.52	GO:0031967	organelle envelope
0.52	GO:0031090	organelle membrane
0.48	GO:0098805	whole membrane
0.46	GO:0019867	outer membrane
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0016021	integral component of membrane

0.80	EC:1.14.13.9	GO:0004502
0.80	KEGG:R01960	GO:0004502

tr|T1EDB0|T1EDB0_HELRO
Uncharacterized protein
Search

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.73	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.57	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
0.56	GO:0071310	cellular response to organic substance
0.55	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
0.55	GO:0043410	positive regulation of MAPK cascade
0.55	GO:0070848	response to growth factor
0.54	GO:0045766	positive regulation of angiogenesis
0.53	GO:0046777	protein autophosphorylation
0.53	GO:0030335	positive regulation of cell migration

0.77	GO:0004713	protein tyrosine kinase activity
0.74	GO:0019199	transmembrane receptor protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0019955	cytokine binding
0.48	GO:0019838	growth factor binding
0.35	GO:0005509	calcium ion binding
0.35	GO:0042802	identical protein binding

0.57	GO:0005887	integral component of plasma membrane
0.50	GO:0015629	actin cytoskeleton
0.49	GO:0009925	basal plasma membrane
0.49	GO:0005902	microvillus
0.47	GO:0016324	apical plasma membrane
0.47	GO:0098857	membrane microdomain
0.46	GO:0009986	cell surface
0.46	GO:0005911	cell-cell junction
0.45	GO:0005815	microtubule organizing center
0.45	GO:0043235	receptor complex

0.77

GO:0004713

tr|T1EDB1|T1EDB1_HELRO
Uncharacterized protein
Search

0.40	Dynein heavy chain

0.74	GO:0007018	microtubule-based movement
0.46	GO:0036159	inner dynein arm assembly
0.34	GO:0016567	protein ubiquitination
0.32	GO:0035556	intracellular signal transduction

0.75	GO:0003777	microtubule motor activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0016887	ATPase activity
0.47	GO:0045503	dynein light chain binding
0.47	GO:0051959	dynein light intermediate chain binding
0.47	GO:0045505	dynein intermediate chain binding
0.35	GO:0005509	calcium ion binding

0.75	GO:0030286	dynein complex
0.45	GO:0044447	axoneme part
0.35	GO:0005874	microtubule
0.30	GO:0031224	intrinsic component of membrane

0.53

GO:0016887

tr|T1EDB2|T1EDB2_HELRO
Uncharacterized protein
Search

LHPP

0.83	Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

0.43	GO:0016311	dephosphorylation
0.36	GO:0036211	protein modification process
0.36	GO:0010970	transport along microtubule
0.35	GO:0044267	cellular protein metabolic process

0.51	GO:0016787	hydrolase activity
0.42	GO:0042803	protein homodimerization activity
0.37	GO:0000287	magnesium ion binding
0.36	GO:0070840	dynein complex binding
0.35	GO:0140096	catalytic activity, acting on a protein
0.34	GO:0003677	DNA binding

0.43	GO:0016607	nuclear speck
0.42	GO:0005829	cytosol
0.36	GO:0005869	dynactin complex
0.30	GO:0031224	intrinsic component of membrane

0.51

GO:0016787

tr|T1EDB3|T1EDB3_HELRO
DNA primase
Search

PRIM1

0.46	DNA primase small subunit

0.74	GO:0006269	DNA replication, synthesis of RNA primer
0.34	GO:1902969	mitotic DNA replication
0.33	GO:0071897	DNA biosynthetic process
0.33	GO:0035556	intracellular signal transduction

0.77	GO:0003896	DNA primase activity
0.42	GO:0003697	single-stranded DNA binding
0.34	GO:0005515	protein binding
0.34	GO:0046872	metal ion binding
0.33	GO:0003887	DNA-directed DNA polymerase activity

0.49	GO:0005658	alpha DNA polymerase:primase complex
0.38	GO:0000790	nuclear chromatin
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.77

GO:0003896

tr|T1EDB4|T1EDB4_HELRO
Uncharacterized protein
Search

0.76	U4 tri-snrnp-associated protein 1

0.75	GO:0000398	mRNA splicing, via spliceosome
0.48	GO:0045583	regulation of cytotoxic T cell differentiation
0.46	GO:0000481	maturation of 5S rRNA
0.45	GO:0045582	positive regulation of T cell differentiation
0.41	GO:0022618	ribonucleoprotein complex assembly
0.36	GO:0046579	positive regulation of Ras protein signal transduction
0.36	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.34	GO:0097193	intrinsic apoptotic signaling pathway
0.34	GO:0007050	cell cycle arrest
0.33	GO:0006635	fatty acid beta-oxidation

0.34	GO:0003723	RNA binding
0.34	GO:0003997	acyl-CoA oxidase activity
0.33	GO:0005515	protein binding
0.32	GO:0008378	galactosyltransferase activity

0.45	GO:0015030	Cajal body
0.44	GO:0071013	catalytic step 2 spliceosome
0.44	GO:0016607	nuclear speck
0.43	GO:0046540	U4/U6 x U5 tri-snRNP complex
0.41	GO:0005794	Golgi apparatus
0.36	GO:0071011	precatalytic spliceosome
0.33	GO:0005777	peroxisome
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.34

EC:1.3.3.6

GO:0003997

tr|T1EDB5|T1EDB5_HELRO
Uncharacterized protein
Search

0.72	GO:0071805	potassium ion transmembrane transport
0.45	GO:0030322	stabilization of membrane potential
0.40	GO:0071467	cellular response to pH
0.36	GO:0042321	negative regulation of circadian sleep/wake cycle, sleep
0.36	GO:0045837	negative regulation of membrane potential
0.36	GO:1903351	cellular response to dopamine
0.34	GO:1902358	sulfate transmembrane transport
0.34	GO:0006855	drug transmembrane transport
0.33	GO:0032259	methylation

0.76	GO:0005267	potassium channel activity
0.44	GO:0022842	narrow pore channel activity
0.41	GO:0022843	voltage-gated cation channel activity
0.39	GO:0005227	calcium activated cation channel activity
0.34	GO:0008271	secondary active sulfate transmembrane transporter activity
0.33	GO:0015238	drug transmembrane transporter activity
0.33	GO:0008168	methyltransferase activity
0.33	GO:0099094	ligand-gated cation channel activity
0.33	GO:0008375	acetylglucosaminyltransferase activity

0.39

GO:0005887

integral component of plasma membrane

0.33

GO:0008168

tr|T1EDB6|T1EDB6_HELRO
Uncharacterized protein
Search

0.49	Sodium bicarbonate cotransporter 3

0.69	GO:0015698	inorganic anion transport
0.68	GO:0098656	anion transmembrane transport
0.44	GO:0015701	bicarbonate transport
0.43	GO:0051453	regulation of intracellular pH
0.41	GO:0035725	sodium ion transmembrane transport
0.34	GO:0010037	response to carbon dioxide
0.34	GO:0010446	response to alkaline pH
0.34	GO:0014823	response to activity
0.34	GO:0048565	digestive tract development
0.34	GO:0010447	response to acidic pH

0.83	GO:0005452	inorganic anion exchanger activity
0.45	GO:0015301	anion:anion antiporter activity
0.45	GO:0015106	bicarbonate transmembrane transporter activity
0.41	GO:0015296	anion:cation symporter activity
0.40	GO:0015081	sodium ion transmembrane transporter activity
0.37	GO:0030506	ankyrin binding
0.36	GO:0015108	chloride transmembrane transporter activity
0.35	GO:0042803	protein homodimerization activity
0.34	GO:0019899	enzyme binding
0.34	GO:0008022	protein C-terminus binding

0.39	GO:0005887	integral component of plasma membrane
0.39	GO:0016323	basolateral plasma membrane
0.37	GO:0016324	apical plasma membrane
0.36	GO:0030863	cortical cytoskeleton
0.35	GO:0030054	cell junction
0.34	GO:0072562	blood microparticle
0.34	GO:0030018	Z disc
0.34	GO:0070062	extracellular exosome
0.33	GO:0009986	cell surface

tr|T1EDB7|T1EDB7_HELRO
Uncharacterized protein
Search

0.58	Nitrilase and fragile histidine triad fusion protein NitFhit

0.45	GO:0006807	nitrogen compound metabolic process
0.42	GO:0007165	signal transduction
0.33	GO:0043547	positive regulation of GTPase activity
0.32	GO:1901360	organic cyclic compound metabolic process
0.32	GO:0046483	heterocycle metabolic process
0.32	GO:0006725	cellular aromatic compound metabolic process
0.32	GO:0010467	gene expression
0.32	GO:0009059	macromolecule biosynthetic process
0.32	GO:0044260	cellular macromolecule metabolic process
0.32	GO:0044249	cellular biosynthetic process

0.40	GO:0016787	hydrolase activity
0.38	GO:0016746	transferase activity, transferring acyl groups
0.34	GO:1902936	phosphatidylinositol bisphosphate binding
0.33	GO:0005096	GTPase activator activity

0.45	GO:0005856	cytoskeleton
0.34	GO:0005669	transcription factor TFIID complex
0.34	GO:0005739	mitochondrion
0.34	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.40

GO:0016787

tr|T1EDB8|T1EDB8_HELRO
Uncharacterized protein
Search

0.54	GO:0055085	transmembrane transport
0.47	GO:0015807	L-amino acid transport
0.36	GO:0015809	arginine transport
0.34	GO:0015893	drug transport
0.34	GO:0006468	protein phosphorylation

0.56	GO:0022857	transmembrane transporter activity
0.34	GO:0004672	protein kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0003677	DNA binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.34

GO:0005887

integral component of plasma membrane

tr|T1EDB9|T1EDB9_HELRO
Uncharacterized protein
Search

0.47	GO:1903506	regulation of nucleic acid-templated transcription
0.47	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.46	GO:0010468	regulation of gene expression
0.36	GO:0006351	transcription, DNA-templated
0.34	GO:0008654	phospholipid biosynthetic process
0.34	GO:0016540	protein autoprocessing
0.33	GO:0046337	phosphatidylethanolamine metabolic process
0.33	GO:0001522	pseudouridine synthesis
0.33	GO:0045017	glycerolipid biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.45	GO:0046872	metal ion binding
0.42	GO:0003700	DNA binding transcription factor activity
0.35	GO:0004609	phosphatidylserine decarboxylase activity
0.33	GO:0009982	pseudouridine synthase activity
0.32	GO:0005515	protein binding

0.39	GO:0005622	intracellular
0.36	GO:0043227	membrane-bounded organelle
0.32	GO:0031975	envelope
0.32	GO:0044422	organelle part
0.30	GO:0016020	membrane

0.35	EC:4.1.1.65	GO:0004609
0.35	KEGG:R02055	GO:0004609

tr|T1EDC0|T1EDC0_HELRO
Uncharacterized protein
Search

GLRA1

0.82	glycine receptor precursor

0.61	GO:0007165	signal transduction
0.60	GO:0034220	ion transmembrane transport
0.52	GO:0060078	regulation of postsynaptic membrane potential
0.51	GO:0006821	chloride transport
0.51	GO:0007268	chemical synaptic transmission
0.42	GO:0043200	response to amino acid
0.37	GO:0045664	regulation of neuron differentiation
0.37	GO:0007417	central nervous system development
0.35	GO:0071294	cellular response to zinc ion
0.35	GO:0071361	cellular response to ethanol

0.75	GO:0005230	extracellular ligand-gated ion channel activity
0.70	GO:0004888	transmembrane signaling receptor activity
0.61	GO:0016594	glycine binding
0.56	GO:0099095	ligand-gated anion channel activity
0.55	GO:0022835	transmitter-gated channel activity
0.51	GO:0005254	chloride channel activity
0.33	GO:0004190	aspartic-type endopeptidase activity
0.33	GO:0008270	zinc ion binding
0.33	GO:0140110	transcription regulator activity

0.55	GO:0005886	plasma membrane
0.51	GO:0098794	postsynapse
0.36	GO:0043204	perikaryon
0.36	GO:0034707	chloride channel complex
0.35	GO:0030425	dendrite
0.35	GO:0030054	cell junction
0.35	GO:1902711	GABA-A receptor complex
0.32	GO:0016592	mediator complex

0.33

EC:3.4.23

GO:0004190

tr|T1EDC1|T1EDC1_HELRO
Uncharacterized protein
Search

HSPA12A

0.79	Heat shock protein 12A isoform B

0.73	GO:0002040	sprouting angiogenesis
0.38	GO:0006508	proteolysis

0.41	GO:0030554	adenyl nucleotide binding
0.41	GO:0070001	aspartic-type peptidase activity
0.40	GO:0097367	carbohydrate derivative binding
0.40	GO:0008144	drug binding
0.40	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0005515	protein binding
0.39	GO:0004175	endopeptidase activity

0.46	GO:0070062	extracellular exosome
0.30	GO:0044425	membrane part

tr|T1EDC2|T1EDC2_HELRO
Uncharacterized protein
Search

LOC106154985

0.60	E3 SUMO-protein ligase PIAS1

0.51	GO:0016925	protein sumoylation
0.42	GO:0033235	positive regulation of protein sumoylation
0.41	GO:0045444	fat cell differentiation
0.41	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.40	GO:0051152	positive regulation of smooth muscle cell differentiation
0.39	GO:0000122	negative regulation of transcription by RNA polymerase II
0.39	GO:0008542	visual learning
0.39	GO:0042127	regulation of cell proliferation
0.39	GO:0007259	JAK-STAT cascade
0.39	GO:0000082	G1/S transition of mitotic cell cycle

0.63	GO:0008270	zinc ion binding
0.61	GO:0016874	ligase activity
0.51	GO:0019789	SUMO transferase activity
0.40	GO:0031625	ubiquitin protein ligase binding
0.39	GO:0061659	ubiquitin-like protein ligase activity
0.39	GO:0008022	protein C-terminus binding
0.38	GO:0008134	transcription factor binding
0.38	GO:0003714	transcription corepressor activity
0.38	GO:0019904	protein domain specific binding
0.36	GO:0051427	hormone receptor binding

0.41	GO:0016605	PML body
0.38	GO:0016607	nuclear speck

0.61

GO:0016874

tr|T1EDC3|T1EDC3_HELRO
Uncharacterized protein
Search

OTP

0.87	Homeobox protein orthopedia

0.65	GO:0007275	multicellular organism development
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:2000648	positive regulation of stem cell proliferation
0.51	GO:2000179	positive regulation of neural precursor cell proliferation
0.48	GO:0010720	positive regulation of cell development
0.48	GO:0051962	positive regulation of nervous system development
0.48	GO:0060322	head development
0.46	GO:0030154	cell differentiation

0.64	GO:0043565	sequence-specific DNA binding
0.34	GO:0004000	adenosine deaminase activity

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.34

EC:3.5.4.4

GO:0004000

tr|T1EDC4|T1EDC4_HELRO
Uncharacterized protein
Search

tr|T1EDC5|T1EDC5_HELRO
Uncharacterized protein
Search

VPS52

0.89	Vacuolar protein sorting-associated protein 52

0.60	GO:0048611	embryonic ectodermal digestive tract development
0.60	GO:0010668	ectodermal cell differentiation
0.58	GO:0007041	lysosomal transport
0.58	GO:0032456	endocytic recycling
0.55	GO:0006896	Golgi to vacuole transport
0.53	GO:0042147	retrograde transport, endosome to Golgi
0.42	GO:0015031	protein transport
0.37	GO:0006887	exocytosis
0.36	GO:0006313	transposition, DNA-mediated
0.36	GO:0032259	methylation

0.57	GO:0019905	syntaxin binding
0.53	GO:0017137	Rab GTPase binding
0.36	GO:0008168	methyltransferase activity
0.35	GO:0003676	nucleic acid binding

0.60	GO:0000938	GARP complex
0.58	GO:1990745	EARP complex
0.52	GO:0048471	perinuclear region of cytoplasm
0.47	GO:0005829	cytosol
0.47	GO:0010008	endosome membrane
0.40	GO:0032588	trans-Golgi network membrane
0.37	GO:0000145	exocyst
0.30	GO:0016021	integral component of membrane

0.36

GO:0008168

tr|T1EDC6|T1EDC6_HELRO
Sodium/potassium-transporting ATPase subunit alpha
Search

0.64	Sodium/potassium-transporting ATPase subunit alpha-B

0.85	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
0.76	GO:0090662	ATP hydrolysis coupled transmembrane transport
0.73	GO:0006814	sodium ion transport
0.71	GO:0006813	potassium ion transport
0.46	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.42	GO:0055080	cation homeostasis
0.42	GO:0098771	inorganic ion homeostasis
0.41	GO:0032501	multicellular organismal process
0.40	GO:0006873	cellular ion homeostasis
0.40	GO:0030317	flagellated sperm motility

0.85	GO:0005391	sodium:potassium-exchanging ATPase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.53	GO:0046872	metal ion binding
0.38	GO:0008900	potassium:proton exchanging ATPase activity
0.35	GO:1990239	steroid hormone binding
0.34	GO:0051087	chaperone binding

0.37	GO:0016323	basolateral plasma membrane
0.36	GO:0005890	sodium:potassium-exchanging ATPase complex
0.34	GO:0030315	T-tubule
0.34	GO:0043209	myelin sheath
0.34	GO:0016324	apical plasma membrane
0.34	GO:0045202	synapse
0.33	GO:0005794	Golgi apparatus
0.33	GO:0005783	endoplasmic reticulum

0.85

EC:3.6.3.9

GO:0005391

tr|T1EDC7|T1EDC7_HELRO
Acetyl-coenzyme A synthetase
Search

ACSS2

0.60	Acetyl-coenzyme A synthetase, cytoplasmic

0.79	GO:0019427	acetyl-CoA biosynthetic process from acetate
0.50	GO:0019542	propionate biosynthetic process
0.49	GO:0019413	acetate biosynthetic process
0.41	GO:0006069	ethanol oxidation
0.40	GO:0007005	mitochondrion organization

0.79	GO:0016208	AMP binding
0.78	GO:0003987	acetate-CoA ligase activity
0.37	GO:0005524	ATP binding

0.42	GO:0005654	nucleoplasm
0.41	GO:0005829	cytosol
0.40	GO:0005759	mitochondrial matrix
0.30	GO:0031224	intrinsic component of membrane

0.78

EC:6.2.1.1

GO:0003987

tr|T1EDC8|T1EDC8_HELRO
Uncharacterized protein
Search

0.63	Sentrin-specific protease 1

0.61	GO:0006508	proteolysis
0.55	GO:0010724	regulation of definitive erythrocyte differentiation
0.52	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
0.52	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
0.50	GO:0097190	apoptotic signaling pathway
0.49	GO:0018205	peptidyl-lysine modification
0.48	GO:0070647	protein modification by small protein conjugation or removal
0.48	GO:0045944	positive regulation of transcription by RNA polymerase II
0.33	GO:0007275	multicellular organism development

0.72	GO:0008234	cysteine-type peptidase activity
0.54	GO:0070122	isopeptidase activity
0.41	GO:0004175	endopeptidase activity
0.37	GO:0102491	dGTP phosphohydrolase activity
0.37	GO:0102490	8-oxo-dGTP phosphohydrolase activity
0.37	GO:0102486	dCTP phosphohydrolase activity
0.37	GO:0102487	dUTP phosphohydrolase activity
0.37	GO:0102485	dATP phosphohydrolase activity
0.37	GO:0102488	dTTP phosphohydrolase activity
0.37	GO:0102489	GTP phosphohydrolase activity

0.49	GO:0005925	focal adhesion
0.49	GO:0031965	nuclear membrane
0.33	GO:0005654	nucleoplasm
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.72

EC:3.4

GO:0008234

tr|T1EDC9|T1EDC9_HELRO
Uncharacterized protein
Search

0.83	LIM and senescent cell antigen-containing domain protein 1

0.47	GO:0007475	apposition of dorsal and ventral imaginal disc-derived wing surfaces
0.46	GO:0008258	head involution
0.46	GO:0046329	negative regulation of JNK cascade
0.46	GO:0007391	dorsal closure
0.45	GO:0009880	embryonic pattern specification
0.42	GO:0043043	peptide biosynthetic process
0.40	GO:0044267	cellular protein metabolic process
0.40	GO:0010467	gene expression
0.39	GO:0009059	macromolecule biosynthetic process
0.39	GO:2001141	regulation of RNA biosynthetic process

0.54	GO:0046872	metal ion binding
0.44	GO:0003735	structural constituent of ribosome
0.42	GO:0046983	protein dimerization activity
0.38	GO:0003677	DNA binding

0.44	GO:0005925	focal adhesion
0.44	GO:0031252	cell leading edge
0.43	GO:0005840	ribosome
0.40	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EDD0|T1EDD0_HELRO
Uncharacterized protein
Search

MPHOSPH10

0.74	U3 small nucleolar ribonucleoprotein protein MPP10

0.67	GO:0006364	rRNA processing
0.50	GO:0010923	negative regulation of phosphatase activity
0.44	GO:0042274	ribosomal small subunit biogenesis
0.34	GO:0000375	RNA splicing, via transesterification reactions

0.34	GO:0005515	protein binding
0.34	GO:0003723	RNA binding

0.82	GO:0034457	Mpp10 complex
0.77	GO:0005732	small nucleolar ribonucleoprotein complex
0.57	GO:0019013	viral nucleocapsid
0.45	GO:0032040	small-subunit processome
0.35	GO:0005694	chromosome
0.34	GO:0005654	nucleoplasm

tr|T1EDD1|T1EDD1_HELRO
Uncharacterized protein
Search

0.55	Suppression of tumorigenicity 5

0.66	GO:0065009	regulation of molecular function
0.48	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.35	GO:0055114	oxidation-reduction process

0.84	GO:0017112	Rab guanyl-nucleotide exchange factor activity
0.37	GO:0016651	oxidoreductase activity, acting on NAD(P)H

0.30

GO:0031224

intrinsic component of membrane

0.37

EC:1.6

GO:0016651

tr|T1EDD2|T1EDD2_HELRO
Uncharacterized protein
Search

MVP

0.94	Major vault protein-alpha

0.62	GO:0031953	negative regulation of protein autophosphorylation
0.60	GO:0061099	negative regulation of protein tyrosine kinase activity
0.59	GO:0038127	ERBB signaling pathway
0.53	GO:0023051	regulation of signaling
0.38	GO:0072376	protein activation cascade
0.37	GO:0008283	cell proliferation
0.36	GO:0031102	neuron projection regeneration
0.36	GO:0043312	neutrophil degranulation
0.35	GO:0001654	eye development
0.35	GO:0007420	brain development

0.58	GO:0019903	protein phosphatase binding
0.55	GO:0019901	protein kinase binding
0.53	GO:0042802	identical protein binding

0.60	GO:0030529	intracellular ribonucleoprotein complex
0.56	GO:0048471	perinuclear region of cytoplasm
0.50	GO:0005856	cytoskeleton
0.50	GO:0005829	cytosol
0.49	GO:0005634	nucleus
0.37	GO:0070062	extracellular exosome
0.36	GO:1904813	ficolin-1-rich granule lumen
0.36	GO:0034774	secretory granule lumen
0.35	GO:0045335	phagocytic vesicle
0.33	GO:0031967	organelle envelope

tr|T1EDD3|T1EDD3_HELRO
Uncharacterized protein
Search

VPS11

0.88	Vacuolar protein sorting-associated protein 11

0.69	GO:0006886	intracellular protein transport
0.69	GO:0016192	vesicle-mediated transport
0.50	GO:1901998	toxin transport
0.49	GO:0007033	vacuole organization
0.47	GO:0035542	regulation of SNARE complex assembly
0.46	GO:0007032	endosome organization
0.46	GO:1902362	melanocyte apoptotic process
0.46	GO:0060035	notochord cell development
0.45	GO:0048794	swim bladder development
0.45	GO:0003406	retinal pigment epithelium development

0.45	GO:0030674	protein binding, bridging
0.37	GO:0019905	syntaxin binding
0.36	GO:0019904	protein domain specific binding
0.35	GO:0004418	hydroxymethylbilane synthase activity
0.34	GO:0004555	alpha,alpha-trehalase activity
0.33	GO:0046872	metal ion binding
0.33	GO:1901265	nucleoside phosphate binding
0.33	GO:0036094	small molecule binding

0.54	GO:0033263	CORVET complex
0.51	GO:0005884	actin filament
0.51	GO:0030123	AP-3 adaptor complex
0.51	GO:0005769	early endosome
0.47	GO:0030897	HOPS complex
0.39	GO:0005774	vacuolar membrane
0.38	GO:0005764	lysosome
0.37	GO:0005770	late endosome
0.37	GO:0030139	endocytic vesicle
0.36	GO:0010008	endosome membrane

0.35	EC:2.5.1.61	GO:0004418
0.35	KEGG:R00084	GO:0004418

tr|T1EDD4|T1EDD4_HELRO
Uncharacterized protein
Search

COPE

0.74	Coatomer protein complex subunit epsilon

0.80	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.60	GO:0015031	protein transport
0.46	GO:0006891	intra-Golgi vesicle-mediated transport
0.45	GO:0006888	ER to Golgi vesicle-mediated transport

0.61	GO:0005198	structural molecule activity
0.34	GO:0005515	protein binding

0.67	GO:0000139	Golgi membrane
0.67	GO:0031410	cytoplasmic vesicle
0.47	GO:0005654	nucleoplasm
0.45	GO:0012506	vesicle membrane
0.44	GO:0030117	membrane coat
0.44	GO:0098805	whole membrane
0.34	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0005829	cytosol
0.33	GO:0019028	viral capsid
0.30	GO:0016021	integral component of membrane

tr|T1EDD5|T1EDD5_HELRO
Uncharacterized protein
Search

SNRNP200

0.79	Activating signal cointegrator 1 complex subunit 3

0.49	GO:0000398	mRNA splicing, via spliceosome
0.43	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.42	GO:0007283	spermatogenesis
0.37	GO:0001649	osteoblast differentiation
0.35	GO:0007419	ventral cord development
0.34	GO:0010501	RNA secondary structure unwinding
0.34	GO:0022618	ribonucleoprotein complex assembly
0.34	GO:0000278	mitotic cell cycle

0.56	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.49	GO:0008186	RNA-dependent ATPase activity
0.48	GO:0042802	identical protein binding
0.43	GO:0140098	catalytic activity, acting on RNA
0.34	GO:0003860	3-hydroxyisobutyryl-CoA hydrolase activity
0.33	GO:0008270	zinc ion binding

0.55	GO:0019013	viral nucleocapsid
0.53	GO:0030529	intracellular ribonucleoprotein complex
0.53	GO:0120114	Sm-like protein family complex
0.47	GO:0044428	nuclear part
0.45	GO:0031974	membrane-enclosed lumen
0.43	GO:1902494	catalytic complex
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.34

EC:3.1.2.4

GO:0003860

tr|T1EDD6|T1EDD6_HELRO
Uncharacterized protein
Search

0.82	GO:0099643	signal release from synapse
0.82	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.76	GO:0006836	neurotransmitter transport
0.72	GO:0001505	regulation of neurotransmitter levels
0.69	GO:0051649	establishment of localization in cell

0.52	GO:0030554	adenyl nucleotide binding
0.51	GO:0032553	ribonucleotide binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.80	GO:0008021	synaptic vesicle
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDD7|T1EDD7_HELRO
Uncharacterized protein
Search

CAB32

0.66	Calbindin-32

0.41	GO:1903035	negative regulation of response to wounding
0.41	GO:0051480	regulation of cytosolic calcium ion concentration
0.35	GO:0007420	brain development
0.33	GO:0007165	signal transduction
0.31	GO:0022900	electron transport chain

0.70	GO:0005509	calcium ion binding
0.32	GO:0005507	copper ion binding
0.31	GO:0009055	electron transfer activity

0.44	GO:0061175	type II terminal bouton
0.43	GO:0097467	type III terminal bouton
0.38	GO:0005829	cytosol
0.37	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDD8|T1EDD8_HELRO
Uncharacterized protein
Search

0.10	Synaptic vesicle glycoprotein 2

0.55	GO:0055085	transmembrane transport
0.35	GO:0015711	organic anion transport
0.32	GO:0055114	oxidation-reduction process

0.56	GO:0005215	transporter activity
0.32	GO:0016491	oxidoreductase activity
0.32	GO:0046872	metal ion binding

0.35

GO:0005887

integral component of plasma membrane

0.32

GO:0016491

tr|T1EDD9|T1EDD9_HELRO
Uncharacterized protein
Search

0.49	GO:1903506	regulation of nucleic acid-templated transcription
0.49	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.49	GO:0010468	regulation of gene expression
0.35	GO:0000413	protein peptidyl-prolyl isomerization
0.35	GO:0045647	negative regulation of erythrocyte differentiation
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:0006457	protein folding
0.34	GO:0008285	negative regulation of cell proliferation
0.34	GO:1902680	positive regulation of RNA biosynthetic process
0.33	GO:0001522	pseudouridine synthesis

0.51	GO:0003676	nucleic acid binding
0.47	GO:0046872	metal ion binding
0.38	GO:0003700	DNA binding transcription factor activity
0.35	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.33	GO:0009982	pseudouridine synthase activity
0.32	GO:0005515	protein binding

0.41	GO:0005622	intracellular
0.36	GO:0043227	membrane-bounded organelle
0.33	GO:0012505	endomembrane system
0.33	GO:0031975	envelope
0.32	GO:0044422	organelle part
0.30	GO:0031224	intrinsic component of membrane

0.35

GO:0003755

tr|T1EDE0|T1EDE0_HELRO
Uncharacterized protein
Search

CPSF3L

0.75	Cleavage and polyadenylation specificity factor

0.78	GO:0016180	snRNA processing
0.63	GO:0043628	ncRNA 3'-end processing
0.42	GO:0006886	intracellular protein transport
0.41	GO:0043484	regulation of RNA splicing
0.41	GO:0006379	mRNA cleavage
0.41	GO:0006378	mRNA polyadenylation
0.40	GO:0072599	establishment of protein localization to endoplasmic reticulum
0.39	GO:0090150	establishment of protein localization to membrane

0.42	GO:0030942	endoplasmic reticulum signal peptide binding
0.41	GO:0008536	Ran GTPase binding
0.40	GO:0008312	7S RNA binding
0.38	GO:0004527	exonuclease activity

0.65	GO:0032039	integrator complex
0.54	GO:0005829	cytosol
0.41	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
0.41	GO:0005786	signal recognition particle, endoplasmic reticulum targeting

tr|T1EDE1|T1EDE1_HELRO
Uncharacterized protein
Search

UBA6

0.89	Gonadotropin-releasing hormone receptor

0.59	GO:0036211	protein modification process
0.58	GO:0021764	amygdala development
0.56	GO:0060996	dendritic spine development
0.55	GO:0044267	cellular protein metabolic process
0.55	GO:0021766	hippocampus development
0.54	GO:0007612	learning
0.53	GO:0007626	locomotory behavior
0.50	GO:0043632	modification-dependent macromolecule catabolic process
0.49	GO:0030163	protein catabolic process
0.45	GO:0006508	proteolysis

0.76	GO:0008641	ubiquitin-like modifier activating enzyme activity
0.43	GO:0032559	adenyl ribonucleotide binding
0.43	GO:0008144	drug binding
0.43	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0016881	acid-amino acid ligase activity
0.36	GO:0016500	protein-hormone receptor activity
0.36	GO:0004930	G-protein coupled receptor activity
0.35	GO:0004252	serine-type endopeptidase activity
0.34	GO:0005515	protein binding
0.34	GO:0000287	magnesium ion binding

0.39	GO:0005737	cytoplasm
0.35	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.38

EC:6.3.2

GO:0016881

tr|T1EDE2|T1EDE2_HELRO
Uncharacterized protein
Search

0.46	Origin recognition complex subunit 1

0.48	GO:0006270	DNA replication initiation
0.44	GO:0001878	response to yeast
0.43	GO:0040014	regulation of multicellular organism growth
0.43	GO:0051301	cell division
0.43	GO:0006277	DNA amplification
0.42	GO:0043009	chordate embryonic development
0.40	GO:0008283	cell proliferation
0.35	GO:0070318	positive regulation of G0 to G1 transition
0.35	GO:0048661	positive regulation of smooth muscle cell proliferation
0.35	GO:0042023	DNA endoreduplication

0.73	GO:0003682	chromatin binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0003677	DNA binding
0.34	GO:0005515	protein binding
0.34	GO:0005509	calcium ion binding

0.54	GO:0005664	nuclear origin of replication recognition complex
0.50	GO:0000784	nuclear chromosome, telomeric region
0.46	GO:0005730	nucleolus
0.45	GO:0005829	cytosol
0.40	GO:0005886	plasma membrane
0.33	GO:1905369	endopeptidase complex
0.33	GO:0005654	nucleoplasm
0.30	GO:0016021	integral component of membrane

tr|T1EDE3|T1EDE3_HELRO
Uncharacterized protein
Search

0.51	GO:1900074	negative regulation of neuromuscular synaptic transmission
0.51	GO:0007165	signal transduction
0.50	GO:0045887	positive regulation of synaptic growth at neuromuscular junction
0.50	GO:0007614	short-term memory
0.50	GO:0070050	neuron cellular homeostasis
0.49	GO:0048675	axon extension
0.49	GO:0007528	neuromuscular junction development
0.48	GO:0007605	sensory perception of sound
0.46	GO:0036211	protein modification process
0.46	GO:0000226	microtubule cytoskeleton organization

0.46	GO:0004672	protein kinase activity
0.42	GO:0004650	polygalacturonase activity
0.42	GO:0008092	cytoskeletal protein binding
0.42	GO:0030554	adenyl nucleotide binding
0.41	GO:0097367	carbohydrate derivative binding
0.41	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0008144	drug binding
0.41	GO:0005216	ion channel activity
0.40	GO:0016788	hydrolase activity, acting on ester bonds
0.37	GO:0005509	calcium ion binding

0.51	GO:0036062	presynaptic periactive zone
0.49	GO:0043195	terminal bouton
0.49	GO:0031594	neuromuscular junction
0.39	GO:0005576	extracellular region
0.37	GO:0032126	eisosome
0.37	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.42

EC:3.2.1.15

GO:0004650

tr|T1EDE4|T1EDE4_HELRO
Inhibitor of growth protein
Search

0.38	Inhibitor of growth protein

0.79	GO:0008285	negative regulation of cell proliferation
0.74	GO:0016569	covalent chromatin modification
0.70	GO:2000772	regulation of cellular senescence
0.65	GO:0010941	regulation of cell death
0.63	GO:0018393	internal peptidyl-lysine acetylation
0.52	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
0.51	GO:0048133	male germ-line stem cell asymmetric division
0.51	GO:0072520	seminiferous tubule development
0.51	GO:0031065	positive regulation of histone deacetylation
0.50	GO:0007141	male meiosis I

0.65	GO:0003682	chromatin binding
0.54	GO:0046872	metal ion binding
0.51	GO:0035064	methylated histone binding
0.47	GO:0035091	phosphatidylinositol binding
0.47	GO:0032403	protein complex binding
0.39	GO:0003677	DNA binding
0.35	GO:0043994	histone acetyltransferase activity (H3-K23 specific)

0.69	GO:0070776	MOZ/MORF histone acetyltransferase complex
0.51	GO:0016580	Sin3 complex
0.50	GO:0016602	CCAAT-binding factor complex
0.46	GO:0005794	Golgi apparatus
0.44	GO:0005829	cytosol
0.40	GO:0005886	plasma membrane

tr|T1EDE5|T1EDE5_HELRO
Uncharacterized protein
Search

0.71	GO:0016236	macroautophagy
0.58	GO:0051028	mRNA transport

0.71

GO:0043130

ubiquitin binding

0.73	GO:0005776	autophagosome
0.72	GO:0000407	phagophore assembly site
0.49	GO:0005634	nucleus

tr|T1EDE6|T1EDE6_HELRO
Uncharacterized protein
Search

AACS

0.64	Acetoacetyl-CoA synthetase

0.63	GO:0006629	lipid metabolic process
0.40	GO:0034201	response to oleic acid
0.40	GO:0071394	cellular response to testosterone stimulus
0.39	GO:0071397	cellular response to cholesterol
0.39	GO:0050872	white fat cell differentiation
0.39	GO:0060612	adipose tissue development
0.39	GO:0032024	positive regulation of insulin secretion
0.39	GO:0071333	cellular response to glucose stimulus
0.39	GO:0045471	response to ethanol
0.38	GO:0001889	liver development

0.83	GO:0030729	acetoacetate-CoA ligase activity
0.40	GO:0047760	butyrate-CoA ligase activity
0.35	GO:0030554	adenyl nucleotide binding
0.35	GO:0032555	purine ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding

0.38	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.83	EC:6.2.1.16	GO:0030729
0.83	KEGG:R01357	GO:0030729

tr|T1EDE7|T1EDE7_HELRO
Enhancer of polycomb-like protein
Search

0.40	Enhancer of polycomb-like protein

0.71	GO:0006357	regulation of transcription by RNA polymerase II
0.58	GO:0006351	transcription, DNA-templated
0.39	GO:0016573	histone acetylation

0.39

GO:0004402

histone acetyltransferase activity

0.84	GO:0032777	Piccolo NuA4 histone acetyltransferase complex
0.30	GO:0016020	membrane

0.39

GO:0004402

tr|T1EDE8|T1EDE8_HELRO
Uncharacterized protein
Search

ASPDH

0.91	Aspartate dehydrogenase domain containing

0.85	GO:0006742	NADP catabolic process
0.72	GO:0019363	pyridine nucleotide biosynthetic process
0.62	GO:0019674	NAD metabolic process
0.53	GO:0055114	oxidation-reduction process
0.38	GO:0016579	protein deubiquitination

0.71	GO:0033735	aspartate dehydrogenase activity
0.69	GO:0050661	NADP binding
0.38	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.30

GO:0016020

membrane

0.71	EC:1.4.1.21	GO:0033735
0.71	KEGG:R07164 KEGG:R07165	GO:0033735

tr|T1EDE9|T1EDE9_HELRO
Uncharacterized protein
Search

RPL21

0.65	Ribosomal protein 6

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.33	GO:0042391	regulation of membrane potential
0.33	GO:0034765	regulation of ion transmembrane transport
0.33	GO:0071805	potassium ion transmembrane transport
0.32	GO:0007165	signal transduction

0.64	GO:0003735	structural constituent of ribosome
0.33	GO:0005249	voltage-gated potassium channel activity

0.61	GO:0005840	ribosome
0.35	GO:0044445	cytosolic part
0.33	GO:0044446	intracellular organelle part
0.33	GO:0005856	cytoskeleton
0.33	GO:0005887	integral component of plasma membrane

tr|T1EDF0|T1EDF0_HELRO
Uncharacterized protein
Search

0.87	VANGL planar cell polarity protein 2

0.70	GO:0007275	multicellular organism development
0.52	GO:0003402	planar cell polarity pathway involved in axis elongation
0.52	GO:0060028	convergent extension involved in axis elongation
0.52	GO:0060601	lateral sprouting from an epithelium
0.51	GO:0060600	dichotomous subdivision of an epithelial terminal unit
0.51	GO:0036342	post-anal tail morphogenesis
0.51	GO:0001736	establishment of planar polarity
0.51	GO:0090178	regulation of establishment of planar polarity involved in neural tube closure
0.50	GO:0045176	apical protein localization
0.50	GO:0048103	somatic stem cell division

0.35

GO:0005515

protein binding

0.57	GO:0016328	lateral plasma membrane
0.52	GO:0060187	cell pole
0.50	GO:0097517	contractile actin filament bundle
0.49	GO:0042641	actomyosin
0.48	GO:0016323	basolateral plasma membrane
0.48	GO:0016324	apical plasma membrane
0.47	GO:0030134	COPII-coated ER to Golgi transport vesicle
0.46	GO:0005911	cell-cell junction
0.30	GO:0016021	integral component of membrane

tr|T1EDF1|T1EDF1_HELRO
Uncharacterized protein
Search

0.47	Cullin-associated NEDD8-dissociated protein 1

0.86	GO:0010265	SCF complex assembly
0.70	GO:0016567	protein ubiquitination
0.66	GO:0043086	negative regulation of catalytic activity
0.66	GO:0030154	cell differentiation
0.46	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
0.40	GO:0043312	neutrophil degranulation
0.39	GO:0043687	post-translational protein modification
0.38	GO:0006879	cellular iron ion homeostasis
0.36	GO:0010467	gene expression
0.36	GO:0009059	macromolecule biosynthetic process

0.53	GO:0017025	TBP-class protein binding
0.39	GO:0070273	phosphatidylinositol-4-phosphate binding
0.36	GO:0003735	structural constituent of ribosome

0.71	GO:0031461	cullin-RING ubiquitin ligase complex
0.65	GO:0005794	Golgi apparatus
0.64	GO:0005654	nucleoplasm
0.63	GO:0005829	cytosol
0.42	GO:0070062	extracellular exosome
0.41	GO:1904813	ficolin-1-rich granule lumen
0.40	GO:0034774	secretory granule lumen
0.35	GO:0005840	ribosome
0.30	GO:0016020	membrane

tr|T1EDF2|T1EDF2_HELRO
Uncharacterized protein
Search

PRPF38A

0.80	Pre-mRNA-splicing factor 38

0.56	GO:0008380	RNA splicing
0.54	GO:0010389	regulation of G2/M transition of mitotic cell cycle
0.54	GO:0006397	mRNA processing
0.36	GO:0006730	one-carbon metabolic process

0.37	GO:0005515	protein binding
0.36	GO:0004089	carbonate dehydratase activity
0.36	GO:0003723	RNA binding
0.34	GO:0008270	zinc ion binding

0.66	GO:0031965	nuclear membrane
0.64	GO:0071011	precatalytic spliceosome
0.44	GO:0043234	protein complex
0.37	GO:0071013	catalytic step 2 spliceosome
0.36	GO:0005654	nucleoplasm
0.30	GO:0016021	integral component of membrane

0.36

EC:4.2.1.1

GO:0004089

tr|T1EDF3|T1EDF3_HELRO
Uncharacterized protein
Search

0.79	GO:0010738	regulation of protein kinase A signaling
0.43	GO:0016310	phosphorylation
0.40	GO:0006429	leucyl-tRNA aminoacylation
0.39	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0036211	protein modification process
0.35	GO:0051171	regulation of nitrogen compound metabolic process
0.35	GO:0080090	regulation of primary metabolic process
0.35	GO:0010468	regulation of gene expression
0.35	GO:0007017	microtubule-based process

0.80	GO:0034237	protein kinase A regulatory subunit binding
0.55	GO:0003723	RNA binding
0.45	GO:0016301	kinase activity
0.40	GO:0004823	leucine-tRNA ligase activity
0.39	GO:0002161	aminoacyl-tRNA editing activity
0.37	GO:0030554	adenyl nucleotide binding
0.37	GO:0097367	carbohydrate derivative binding
0.37	GO:0008144	drug binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0003700	DNA binding transcription factor activity

0.57	GO:0005739	mitochondrion
0.35	GO:0043232	intracellular non-membrane-bounded organelle
0.35	GO:0005634	nucleus
0.34	GO:0043234	protein complex
0.34	GO:0044446	intracellular organelle part
0.33	GO:0070013	intracellular organelle lumen
0.33	GO:1902494	catalytic complex
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0005618	cell wall
0.32	GO:0005829	cytosol

0.40	EC:6.1.1.4	GO:0004823
0.40	KEGG:R03657	GO:0004823

tr|T1EDF4|T1EDF4_HELRO
Uncharacterized protein
Search

0.63	ileal sodium/bile acid cotransporter-like

0.30

GO:0044425

membrane part

tr|T1EDF5|T1EDF5_HELRO
Uncharacterized protein
Search

0.52	Retinoic acid receptor RXR-alpha-A

0.77	GO:0043401	steroid hormone mediated signaling pathway
0.72	GO:0030522	intracellular receptor signaling pathway
0.58	GO:0097659	nucleic acid-templated transcription
0.57	GO:0006355	regulation of transcription, DNA-templated
0.54	GO:0010467	gene expression
0.53	GO:0034645	cellular macromolecule biosynthetic process
0.43	GO:0071376	cellular response to corticotropin-releasing hormone stimulus
0.43	GO:0048513	animal organ development
0.42	GO:0045444	fat cell differentiation
0.41	GO:1903508	positive regulation of nucleic acid-templated transcription

0.77	GO:0003707	steroid hormone receptor activity
0.74	GO:0004879	nuclear receptor activity
0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.41	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.39	GO:0001223	transcription coactivator binding
0.39	GO:0035035	histone acetyltransferase binding
0.38	GO:0001047	core promoter binding
0.37	GO:0019901	protein kinase binding
0.37	GO:0035259	glucocorticoid receptor binding

0.61	GO:0005634	nucleus
0.40	GO:0005667	transcription factor complex
0.39	GO:0042629	mast cell granule
0.36	GO:0005829	cytosol
0.36	GO:0012505	endomembrane system
0.35	GO:0031967	organelle envelope
0.35	GO:0031090	organelle membrane
0.30	GO:0016021	integral component of membrane

tr|T1EDF6|T1EDF6_HELRO
Uncharacterized protein
Search

0.46	Iron-dependent fumarate hydratase

0.59

GO:0006091

generation of precursor metabolites and energy

0.78	GO:0004333	fumarate hydratase activity
0.60	GO:0051539	4 iron, 4 sulfur cluster binding
0.49	GO:0046872	metal ion binding

0.78	EC:4.2.1.2	GO:0004333
0.78	KEGG:R01082	GO:0004333

tr|T1EDF7|T1EDF7_HELRO
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
Search

SUCLA2

0.69	Succinate-CoA ligase subunit beta

0.71

GO:0006099

tricarboxylic acid cycle

0.71	GO:0004775	succinate-CoA ligase (ADP-forming) activity
0.59	GO:0000287	magnesium ion binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0016829	lyase activity

0.59	GO:0005739	mitochondrion
0.34	GO:0043209	myelin sheath

0.71	EC:6.2.1.5	GO:0004775
0.71	KEGG:R00405	GO:0004775

tr|T1EDF8|T1EDF8_HELRO
Uncharacterized protein
Search

tr|T1EDF9|T1EDF9_HELRO
Uncharacterized protein
Search

DNAJB6B

0.42	DnaJ like protein subfamily B member 6

0.62	GO:0006457	protein folding
0.60	GO:0090084	negative regulation of inclusion body assembly
0.58	GO:0045109	intermediate filament organization
0.56	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.54	GO:0032781	positive regulation of ATPase activity
0.51	GO:0032880	regulation of protein localization
0.48	GO:0060715	syncytiotrophoblast cell differentiation involved in labyrinthine layer development
0.47	GO:0060710	chorio-allantoic fusion
0.46	GO:0060717	chorion development
0.46	GO:0030036	actin cytoskeleton organization

0.64	GO:0051082	unfolded protein binding
0.57	GO:0031072	heat shock protein binding
0.55	GO:0001671	ATPase activator activity
0.53	GO:0051087	chaperone binding
0.44	GO:0008270	zinc ion binding
0.39	GO:0003676	nucleic acid binding
0.38	GO:0032559	adenyl ribonucleotide binding
0.37	GO:0044183	protein binding involved in protein folding
0.37	GO:0008144	drug binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding

0.60	GO:0030018	Z disc
0.58	GO:0048471	perinuclear region of cytoplasm
0.51	GO:0044428	nuclear part
0.49	GO:0031974	membrane-enclosed lumen
0.49	GO:0005829	cytosol
0.39	GO:0012505	endomembrane system
0.38	GO:0031967	organelle envelope
0.37	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

tr|T1EDG0|T1EDG0_HELRO
Uncharacterized protein
Search

0.47	E3 ubiquitin-protein ligase RBBP6

0.70	GO:0016567	protein ubiquitination
0.65	GO:0006397	mRNA processing
0.54	GO:0035264	multicellular organism growth
0.54	GO:0061053	somite development
0.52	GO:0048568	embryonic organ development
0.52	GO:0001701	in utero embryonic development
0.52	GO:0006275	regulation of DNA replication
0.50	GO:0006511	ubiquitin-dependent protein catabolic process
0.46	GO:0006974	cellular response to DNA damage stimulus
0.37	GO:0016055	Wnt signaling pathway

0.71	GO:0004842	ubiquitin-protein transferase activity
0.70	GO:0061659	ubiquitin-like protein ligase activity
0.63	GO:0008270	zinc ion binding
0.52	GO:0019901	protein kinase binding
0.51	GO:0003676	nucleic acid binding
0.47	GO:0016874	ligase activity
0.34	GO:0017056	structural constituent of nuclear pore

0.60	GO:0005634	nucleus
0.52	GO:0005813	centrosome
0.47	GO:0031974	membrane-enclosed lumen
0.44	GO:0043234	protein complex
0.34	GO:0005829	cytosol
0.34	GO:0005694	chromosome
0.30	GO:0016020	membrane

0.47	EC:6	GO:0016874
0.71	KEGG:R03876	GO:0004842

tr|T1EDG1|T1EDG1_HELRO
Uncharacterized protein
Search

0.43	AmmeMemoRadiSam system protein B

0.64	GO:0032886	regulation of microtubule-based process
0.40	GO:0006885	regulation of pH
0.40	GO:0035725	sodium ion transmembrane transport
0.38	GO:0055114	oxidation-reduction process
0.38	GO:0031929	TOR signaling
0.38	GO:0032008	positive regulation of TOR signaling
0.37	GO:1902600	hydrogen ion transmembrane transport

0.44	GO:0051213	dioxygenase activity
0.41	GO:0015385	sodium:proton antiporter activity
0.37	GO:0003723	RNA binding

0.56	GO:0005634	nucleus
0.46	GO:0005737	cytoplasm
0.38	GO:0031931	TORC1 complex
0.38	GO:0031932	TORC2 complex
0.30	GO:0016020	membrane

tr|T1EDG2|T1EDG2_HELRO
Uncharacterized protein
Search

0.54	Short-chain dehydrogenase TIC 32, chloroplastic

0.58	GO:0042572	retinol metabolic process
0.45	GO:0055114	oxidation-reduction process
0.40	GO:0001649	osteoblast differentiation
0.38	GO:0010842	retina layer formation
0.38	GO:0009644	response to high light intensity
0.37	GO:0016311	dephosphorylation
0.37	GO:0042462	eye photoreceptor cell development
0.37	GO:0006633	fatty acid biosynthetic process
0.36	GO:0009117	nucleotide metabolic process

0.58	GO:0008106	alcohol dehydrogenase (NADP+) activity
0.39	GO:0008253	5'-nucleotidase activity
0.38	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
0.38	GO:0016630	protochlorophyllide reductase activity
0.37	GO:0000287	magnesium ion binding
0.36	GO:0051287	NAD binding
0.33	GO:0003676	nucleic acid binding

0.50	GO:0005783	endoplasmic reticulum
0.46	GO:0005739	mitochondrion
0.41	GO:0005765	lysosomal membrane
0.36	GO:0005634	nucleus
0.35	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.35	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.58

EC:1.1.1.2

GO:0008106

tr|T1EDG3|T1EDG3_HELRO
Uncharacterized protein
Search

POGLUT1

0.96	KTEL motif-containing protein 1

0.62	GO:0045747	positive regulation of Notch signaling pathway
0.62	GO:0018242	protein O-linked glycosylation via serine
0.61	GO:0048318	axial mesoderm development
0.60	GO:0048339	paraxial mesoderm development
0.59	GO:0010470	regulation of gastrulation
0.58	GO:0001756	somitogenesis
0.57	GO:0060537	muscle tissue development
0.55	GO:0072358	cardiovascular system development
0.47	GO:0006664	glycolipid metabolic process
0.39	GO:0007369	gastrulation

0.64	GO:0035252	UDP-xylosyltransferase activity
0.58	GO:0046527	glucosyltransferase activity
0.35	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0005515	protein binding

0.62	GO:0005788	endoplasmic reticulum lumen
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.58

GO:0046527

tr|T1EDG4|T1EDG4_HELRO
Uncharacterized protein
Search

tr|T1EDG5|T1EDG5_HELRO
Uncharacterized protein
Search

PSMD6

0.76	26S proteasome non-ATPase regulatory subunit

0.68	GO:0050790	regulation of catalytic activity
0.50	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.46	GO:0070306	lens fiber cell differentiation
0.35	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:1902036	regulation of hematopoietic stem cell differentiation
0.35	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
0.35	GO:0043312	neutrophil degranulation
0.35	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

0.70	GO:0030234	enzyme regulator activity
0.33	GO:0004061	arylformamidase activity
0.33	GO:0005515	protein binding
0.33	GO:0004222	metalloendopeptidase activity
0.33	GO:0016887	ATPase activity
0.32	GO:0008270	zinc ion binding

0.68	GO:1905369	endopeptidase complex
0.56	GO:0043234	protein complex
0.43	GO:0005622	intracellular
0.36	GO:0070062	extracellular exosome
0.35	GO:0031983	vesicle lumen
0.33	GO:0012505	endomembrane system

0.33

EC:3.5.1.9

GO:0004061

tr|T1EDG6|T1EDG6_HELRO
Uncharacterized protein
Search

0.63	Cleavage and polyadenylation specificity factor subunit

0.53	GO:0006378	mRNA polyadenylation
0.46	GO:0060216	definitive hemopoiesis
0.45	GO:0006379	mRNA cleavage
0.34	GO:0006369	termination of RNA polymerase II transcription
0.34	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation
0.34	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.33	GO:0051028	mRNA transport
0.33	GO:0000398	mRNA splicing, via spliceosome
0.33	GO:0006405	RNA export from nucleus

0.51	GO:0003676	nucleic acid binding
0.43	GO:0019899	enzyme binding
0.39	GO:0005509	calcium ion binding
0.33	GO:0017022	myosin binding

0.61	GO:0005634	nucleus
0.44	GO:0031974	membrane-enclosed lumen
0.41	GO:0043234	protein complex
0.40	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

tr|T1EDG7|T1EDG7_HELRO
Uncharacterized protein
Search

0.43	Argininosuccinate lyase

0.77	GO:0042450	arginine biosynthetic process via ornithine
0.35	GO:0000053	argininosuccinate metabolic process
0.35	GO:0060539	diaphragm development
0.35	GO:0071377	cellular response to glucagon stimulus
0.35	GO:0019676	ammonia assimilation cycle
0.35	GO:0007494	midgut development
0.35	GO:0071549	cellular response to dexamethasone stimulus
0.35	GO:0014075	response to amine
0.35	GO:0000050	urea cycle
0.35	GO:0071320	cellular response to cAMP

0.79	GO:0004056	argininosuccinate lyase activity
0.36	GO:0005212	structural constituent of eye lens
0.34	GO:0042802	identical protein binding
0.32	GO:0022857	transmembrane transporter activity

0.47	GO:0005829	cytosol
0.35	GO:0070852	cell body fiber
0.35	GO:0043204	perikaryon
0.34	GO:0070062	extracellular exosome
0.34	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0005741	mitochondrial outer membrane
0.33	GO:0005783	endoplasmic reticulum
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:4.3.2.1

GO:0004056

tr|T1EDG8|T1EDG8_HELRO
Uncharacterized protein
Search

NEK2

0.94	Serine/threonine-protein kinase Nek2

0.63	GO:0006468	protein phosphorylation
0.60	GO:1903126	negative regulation of centriole-centriole cohesion
0.57	GO:0046602	regulation of mitotic centrosome separation
0.57	GO:1904355	positive regulation of telomere capping
0.57	GO:0051299	centrosome separation
0.56	GO:0051973	positive regulation of telomerase activity
0.56	GO:0051988	regulation of attachment of spindle microtubules to kinetochore
0.56	GO:0032212	positive regulation of telomere maintenance via telomerase
0.54	GO:0043392	negative regulation of DNA binding
0.54	GO:0090307	mitotic spindle assembly

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0019903	protein phosphatase binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0045182	translation regulator activity
0.34	GO:0004379	glycylpeptide N-tetradecanoyltransferase activity
0.34	GO:0042302	structural constituent of cuticle
0.33	GO:0046872	metal ion binding
0.32	GO:0008168	methyltransferase activity

0.53	GO:0030496	midbody
0.53	GO:0005813	centrosome
0.52	GO:0000776	kinetochore
0.51	GO:0000922	spindle pole
0.51	GO:0000794	condensed nuclear chromosome
0.48	GO:0005654	nucleoplasm
0.36	GO:0000779	condensed chromosome, centromeric region
0.35	GO:0005730	nucleolus
0.35	GO:0005874	microtubule
0.34	GO:0005581	collagen trimer

0.34

EC:2.3.1.97

GO:0004379

tr|T1EDG9|T1EDG9_HELRO
Uncharacterized protein
Search

SLC25A24

0.91	Calcium-binding mitochondrial carrier protein SCaMC-1-B

0.55	GO:0015867	ATP transport
0.55	GO:0055085	transmembrane transport
0.54	GO:0071277	cellular response to calcium ion
0.52	GO:0006839	mitochondrial transport
0.49	GO:0034599	cellular response to oxidative stress
0.49	GO:0010941	regulation of cell death
0.46	GO:0015866	ADP transport
0.35	GO:0032094	response to food
0.35	GO:0002021	response to dietary excess
0.35	GO:0014823	response to activity

0.68	GO:0005509	calcium ion binding
0.56	GO:0005347	ATP transmembrane transporter activity
0.47	GO:0015217	ADP transmembrane transporter activity
0.34	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.33	GO:0043565	sequence-specific DNA binding

0.60	GO:0031966	mitochondrial membrane
0.60	GO:0019866	organelle inner membrane
0.34	GO:0005777	peroxisome
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0032440

tr|T1EDH0|T1EDH0_HELRO
Uncharacterized protein
Search

EPRS

0.81	Prolyl Amino-acyl tRNA Synthetase

0.79	GO:0006433	prolyl-tRNA aminoacylation
0.71	GO:0006424	glutamyl-tRNA aminoacylation
0.57	GO:0071346	cellular response to interferon-gamma
0.53	GO:0017148	negative regulation of translation

0.79	GO:0004827	proline-tRNA ligase activity
0.72	GO:0004818	glutamate-tRNA ligase activity
0.59	GO:0035613	RNA stem-loop binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0042803	protein homodimerization activity
0.51	GO:0051020	GTPase binding
0.46	GO:0008270	zinc ion binding

0.61	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex
0.60	GO:0097452	GAIT complex
0.49	GO:0005737	cytoplasm
0.45	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0016020	membrane

0.79

EC:6.1.1.15

GO:0004827

tr|T1EDH1|T1EDH1_HELRO
Uncharacterized protein
Search

LRRC58

0.49	LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 58

0.50	GO:0045199	maintenance of epithelial cell apical/basal polarity
0.50	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.40	GO:0007165	signal transduction
0.39	GO:0006887	exocytosis

0.52	GO:0004523	RNA-DNA hybrid ribonuclease activity
0.44	GO:0005509	calcium ion binding
0.40	GO:0003676	nucleic acid binding

0.48	GO:0016323	basolateral plasma membrane
0.39	GO:0000145	exocyst
0.30	GO:0031224	intrinsic component of membrane

0.52

EC:3.1.26.4

GO:0004523

tr|T1EDH2|T1EDH2_HELRO
Uncharacterized protein
Search

0.40	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box

0.53	GO:0000729	DNA double-strand break processing
0.53	GO:0070933	histone H4 deacetylation
0.51	GO:0043044	ATP-dependent chromatin remodeling
0.50	GO:0070932	histone H3 deacetylation
0.50	GO:0000018	regulation of DNA recombination
0.49	GO:0051304	chromosome separation
0.34	GO:0051260	protein homooligomerization
0.34	GO:0045893	positive regulation of transcription, DNA-templated
0.33	GO:0034220	ion transmembrane transport
0.33	GO:0009117	nucleotide metabolic process

0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0003677	DNA binding
0.39	GO:0004386	helicase activity
0.33	GO:0005216	ion channel activity
0.33	GO:0003995	acyl-CoA dehydrogenase activity
0.33	GO:0005515	protein binding
0.33	GO:0050660	flavin adenine dinucleotide binding

0.52	GO:0035861	site of double-strand break
0.51	GO:0043596	nuclear replication fork
0.49	GO:0000792	heterochromatin
0.46	GO:0005654	nucleoplasm
0.34	GO:0016363	nuclear matrix
0.30	GO:0016020	membrane

0.33

EC:1.3.99.3

GO:0003995

tr|T1EDH3|T1EDH3_HELRO
Uncharacterized protein
Search

tr|T1EDH4|T1EDH4_HELRO
Uncharacterized protein
Search

0.78	GO:0031047	gene silencing by RNA
0.70	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.62	GO:0006396	RNA processing
0.54	GO:0071359	cellular response to dsRNA
0.53	GO:0016441	posttranscriptional gene silencing
0.51	GO:0017148	negative regulation of translation
0.49	GO:0016075	rRNA catabolic process
0.48	GO:0022618	ribonucleoprotein complex assembly
0.47	GO:0006309	apoptotic DNA fragmentation
0.41	GO:0009047	dosage compensation by hyperactivation of X chromosome

0.77	GO:0004525	ribonuclease III activity
0.58	GO:0003723	RNA binding
0.47	GO:0004530	deoxyribonuclease I activity
0.47	GO:0030554	adenyl nucleotide binding
0.46	GO:0019904	protein domain specific binding
0.46	GO:0097367	carbohydrate derivative binding
0.46	GO:0008144	drug binding
0.46	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0003677	DNA binding
0.38	GO:0017111	nucleoside-triphosphatase activity

0.52	GO:0070578	RISC-loading complex
0.52	GO:0035068	micro-ribonucleoprotein complex
0.49	GO:0016442	RISC complex
0.48	GO:0070062	extracellular exosome
0.41	GO:0005634	nucleus
0.37	GO:0030426	growth cone
0.37	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.37	GO:0034507	chromosome, centromeric outer repeat region
0.37	GO:0030425	dendrite
0.37	GO:0030424	axon

0.77

EC:3.1.26.3

GO:0004525

tr|T1EDH5|T1EDH5_HELRO
Uncharacterized protein
Search

0.49	Casein kinase (Serine/threonine/tyrosine protein kinase)

0.63	GO:0006468	protein phosphorylation
0.44	GO:0018209	peptidyl-serine modification
0.41	GO:0008360	regulation of cell shape
0.41	GO:0045879	negative regulation of smoothened signaling pathway
0.40	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.40	GO:0090090	negative regulation of canonical Wnt signaling pathway
0.39	GO:0042593	glucose homeostasis
0.38	GO:0016055	Wnt signaling pathway
0.38	GO:0000902	cell morphogenesis
0.38	GO:0006897	endocytosis

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0008474	palmitoyl-(protein) hydrolase activity
0.33	GO:0005515	protein binding

0.40	GO:0005634	nucleus
0.37	GO:0005737	cytoplasm
0.32	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

0.34

EC:3.1.2.22

GO:0008474

tr|T1EDH6|T1EDH6_HELRO
V-type proton ATPase subunit C
Search

0.67	V-type proton ATPase subunit C

0.76	GO:0015991	ATP hydrolysis coupled proton transport
0.33	GO:0009116	nucleoside metabolic process

0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.50	GO:0036442	proton-exporting ATPase activity
0.49	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
0.42	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism

0.80	GO:0033180	proton-transporting V-type ATPase, V1 domain
0.45	GO:0016471	vacuolar proton-transporting V-type ATPase complex
0.45	GO:0005765	lysosomal membrane
0.40	GO:0005886	plasma membrane

tr|T1EDH7|T1EDH7_HELRO
Uncharacterized protein
Search

0.10	Thyroid hormone receptor interactor 12

0.72	GO:0016567	protein ubiquitination
0.41	GO:1901314	regulation of histone H2A K63-linked ubiquitination
0.41	GO:0033183	negative regulation of histone ubiquitination
0.41	GO:1900045	negative regulation of protein K63-linked ubiquitination
0.40	GO:2000780	negative regulation of double-strand break repair
0.40	GO:0006511	ubiquitin-dependent protein catabolic process
0.39	GO:0045995	regulation of embryonic development
0.37	GO:0006974	cellular response to DNA damage stimulus
0.32	GO:0006259	DNA metabolic process
0.32	GO:0006518	peptide metabolic process

0.72	GO:0004842	ubiquitin-protein transferase activity
0.62	GO:0008270	zinc ion binding
0.54	GO:0016874	ligase activity
0.40	GO:0046966	thyroid hormone receptor binding
0.38	GO:0061659	ubiquitin-like protein ligase activity
0.32	GO:0003676	nucleic acid binding
0.32	GO:0003735	structural constituent of ribosome

0.38	GO:0016607	nuclear speck
0.34	GO:0005737	cytoplasm
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016020	membrane

0.54	EC:6	GO:0016874
0.72	KEGG:R03876	GO:0004842

tr|T1EDH8|T1EDH8_HELRO
Uncharacterized protein
Search

0.76	Eukaryotic translation initiation factor 5B

0.66	GO:0006413	translational initiation
0.40	GO:0006446	regulation of translational initiation
0.33	GO:0006414	translational elongation

0.68	GO:0003924	GTPase activity
0.66	GO:0003743	translation initiation factor activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0017151	DEAD/H-box RNA helicase binding
0.34	GO:0004781	sulfate adenylyltransferase (ATP) activity
0.33	GO:0003746	translation elongation factor activity
0.32	GO:0046872	metal ion binding

0.35	GO:0005829	cytosol
0.35	GO:0061617	MICOS complex
0.33	GO:0005634	nucleus

0.34

EC:2.7.7.4

GO:0004781

tr|T1EDH9|T1EDH9_HELRO
Proteasome subunit beta type
Search

PSMB7

0.53	Proteasome subunit beta type

0.71	GO:0051603	proteolysis involved in cellular protein catabolic process
0.51	GO:1903955	positive regulation of protein targeting to mitochondrion
0.36	GO:0043632	modification-dependent macromolecule catabolic process
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.35	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:1902036	regulation of hematopoietic stem cell differentiation
0.35	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia

0.76	GO:0004298	threonine-type endopeptidase activity
0.33	GO:0005515	protein binding
0.33	GO:0016301	kinase activity

0.75	GO:0005839	proteasome core complex
0.59	GO:0005634	nucleus
0.47	GO:0005737	cytoplasm
0.44	GO:0070013	intracellular organelle lumen
0.40	GO:0044446	intracellular organelle part
0.36	GO:0070062	extracellular exosome
0.35	GO:0031983	vesicle lumen
0.33	GO:0097708	intracellular vesicle
0.33	GO:0012505	endomembrane system

0.76

EC:3.4.25

GO:0004298

tr|T1EDI0|T1EDI0_HELRO
Kinesin-like protein
Search

tr|T1EDI1|T1EDI1_HELRO
Uncharacterized protein
Search

SLIT2

0.93	Slit guidance ligand 2

0.58	GO:0050929	induction of negative chemotaxis
0.57	GO:0021952	central nervous system projection neuron axonogenesis
0.55	GO:0050771	negative regulation of axonogenesis
0.55	GO:0030308	negative regulation of cell growth
0.55	GO:0035385	Roundabout signaling pathway
0.55	GO:0070100	negative regulation of chemokine-mediated signaling pathway
0.55	GO:0061364	apoptotic process involved in luteolysis
0.55	GO:0021836	chemorepulsion involved in postnatal olfactory bulb interneuron migration
0.54	GO:0010593	negative regulation of lamellipodium assembly
0.54	GO:0090024	negative regulation of neutrophil chemotaxis

0.70	GO:0005509	calcium ion binding
0.57	GO:0048495	Roundabout binding
0.54	GO:0043237	laminin-1 binding
0.53	GO:0005095	GTPase inhibitor activity
0.52	GO:0008201	heparin binding
0.52	GO:0043394	proteoglycan binding
0.47	GO:0042803	protein homodimerization activity
0.35	GO:0045499	chemorepellent activity
0.32	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding

0.59	GO:0005576	extracellular region
0.42	GO:0071666	Slit-Robo signaling complex
0.37	GO:0005737	cytoplasm
0.35	GO:0031982	vesicle
0.34	GO:0009986	cell surface
0.34	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1EDI2|T1EDI2_HELRO
Uncharacterized protein
Search

0.72	I'm not dead yet

0.73	GO:0006814	sodium ion transport
0.55	GO:0055085	transmembrane transport
0.42	GO:0015744	succinate transport
0.40	GO:0015746	citrate transport
0.35	GO:0008272	sulfate transport
0.34	GO:0008340	determination of adult lifespan
0.32	GO:0006351	transcription, DNA-templated
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.56	GO:0005215	transporter activity
0.32	GO:0043565	sequence-specific DNA binding
0.32	GO:0003700	DNA binding transcription factor activity

0.38	GO:0005887	integral component of plasma membrane
0.32	GO:0005634	nucleus

tr|T1EDI3|T1EDI3_HELRO
Uncharacterized protein
Search

0.10	Serine and arginine rich splicing factor 4

0.41	GO:0048025	negative regulation of mRNA splicing, via spliceosome
0.36	GO:0006397	mRNA processing
0.35	GO:0002244	hematopoietic progenitor cell differentiation
0.35	GO:0032868	response to insulin
0.33	GO:0097010	eukaryotic translation initiation factor 4F complex assembly
0.33	GO:0006368	transcription elongation from RNA polymerase II promoter
0.33	GO:0019087	transformation of host cell by virus
0.33	GO:0016570	histone modification
0.33	GO:0008380	RNA splicing
0.33	GO:0007186	G-protein coupled receptor signaling pathway

0.57	GO:0003723	RNA binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0004930	G-protein coupled receptor activity
0.32	GO:0004672	protein kinase activity
0.32	GO:0032553	ribonucleotide binding
0.32	GO:0017076	purine nucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003924	GTPase activity
0.32	GO:0008144	drug binding
0.32	GO:0032550	purine ribonucleoside binding

0.39	GO:0031981	nuclear lumen
0.36	GO:0005829	cytosol
0.35	GO:0043232	intracellular non-membrane-bounded organelle
0.34	GO:0099512	supramolecular fiber
0.33	GO:0055029	nuclear DNA-directed RNA polymerase complex
0.32	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDI4|T1EDI4_HELRO
DNA-directed RNA polymerase subunit
Search

POLR2A

0.48	DNA-directed RNA polymerase subunit

0.71	GO:0006366	transcription by RNA polymerase II
0.42	GO:2000543	positive regulation of gastrulation
0.41	GO:0009299	mRNA transcription
0.41	GO:0051254	positive regulation of RNA metabolic process
0.40	GO:0010628	positive regulation of gene expression
0.40	GO:0007369	gastrulation
0.40	GO:0009792	embryo development ending in birth or egg hatching
0.38	GO:0010557	positive regulation of macromolecule biosynthetic process
0.38	GO:0031328	positive regulation of cellular biosynthetic process
0.38	GO:0043484	regulation of RNA splicing

0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.55	GO:0003677	DNA binding
0.44	GO:0001067	regulatory region nucleic acid binding
0.36	GO:0031625	ubiquitin protein ligase binding
0.35	GO:0046872	metal ion binding
0.33	GO:0005524	ATP binding
0.33	GO:0004713	protein tyrosine kinase activity
0.32	GO:0016491	oxidoreductase activity
0.32	GO:0003723	RNA binding
0.32	GO:0003968	RNA-directed 5'-3' RNA polymerase activity

0.76	GO:0005665	DNA-directed RNA polymerase II, core complex
0.46	GO:0005719	nuclear euchromatin
0.41	GO:0035327	transcriptionally active chromatin
0.39	GO:0000974	Prp19 complex
0.35	GO:0005730	nucleolus
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.70

GO:0003899

tr|T1EDI5|T1EDI5_HELRO
Uncharacterized protein
Search

tr|T1EDI6|T1EDI6_HELRO
Uncharacterized protein
Search

RAB27A

0.87	Small GTPase Rab27

0.54	GO:0045921	positive regulation of exocytosis
0.50	GO:0071985	multivesicular body sorting pathway
0.50	GO:0032400	melanosome localization
0.50	GO:0051904	pigment granule transport
0.39	GO:0045055	regulated exocytosis
0.39	GO:0097278	complement-dependent cytotoxicity
0.39	GO:1903433	regulation of constitutive secretory pathway
0.39	GO:1990182	exosomal secretion
0.38	GO:0036257	multivesicular body organization
0.38	GO:0050766	positive regulation of phagocytosis

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0031489	myosin V binding
0.47	GO:0019904	protein domain specific binding

0.54	GO:0042470	melanosome
0.53	GO:0032585	multivesicular body membrane
0.49	GO:0030133	transport vesicle
0.48	GO:0005795	Golgi stack
0.48	GO:0030136	clathrin-coated vesicle
0.48	GO:0099503	secretory vesicle
0.47	GO:0005798	Golgi-associated vesicle
0.40	GO:0097458	neuron part
0.38	GO:0044456	synapse part
0.37	GO:0005764	lysosome

tr|T1EDI7|T1EDI7_HELRO
Uncharacterized protein
Search

LOC108734212

0.83	Tousled like protein kinase

0.63	GO:0006468	protein phosphorylation
0.42	GO:0045448	mitotic cell cycle, embryonic
0.41	GO:0070868	heterochromatin organization involved in chromatin silencing
0.41	GO:0019730	antimicrobial humoral response
0.39	GO:0016570	histone modification
0.38	GO:0051726	regulation of cell cycle
0.38	GO:0007059	chromosome segregation

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005515	protein binding

0.40	GO:0000792	heterochromatin
0.36	GO:0005634	nucleus
0.36	GO:0031974	membrane-enclosed lumen
0.30	GO:0016020	membrane

tr|T1EDI8|T1EDI8_HELRO
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
Search

0.43	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

0.70	GO:0006633	fatty acid biosynthetic process
0.53	GO:0046726	positive regulation by virus of viral protein levels in host cell
0.52	GO:0000038	very long-chain fatty acid metabolic process
0.51	GO:0045070	positive regulation of viral genome replication
0.51	GO:0007254	JNK cascade
0.51	GO:0007249	I-kappaB kinase/NF-kappaB signaling
0.50	GO:0007266	Rho protein signal transduction
0.45	GO:0030148	sphingolipid biosynthetic process
0.35	GO:0016601	Rac protein signal transduction
0.34	GO:0043507	positive regulation of JUN kinase activity

0.85	GO:0102158	very-long-chain 3-hydroxyacyl-CoA dehydratase activity
0.85	GO:0102343	3-hydroxy-arachidoyl-CoA dehydratase activity
0.85	GO:0102345	3-hydroxy-lignoceroyl-CoA dehydratase activity
0.85	GO:0102344	3-hydroxy-behenoyl-CoA dehydratase activity
0.55	GO:0018812	3-hydroxyacyl-CoA dehydratase activity
0.46	GO:0019899	enzyme binding
0.34	GO:0005096	GTPase activator activity

0.72	GO:0005789	endoplasmic reticulum membrane
0.49	GO:0031965	nuclear membrane
0.44	GO:0005829	cytosol
0.42	GO:0005739	mitochondrion
0.35	GO:0005925	focal adhesion
0.30	GO:0016021	integral component of membrane

0.85

EC:4.2.1.134

GO:0102343

tr|T1EDI9|T1EDI9_HELRO
Uncharacterized protein
Search

tr|T1EDJ0|T1EDJ0_HELRO
Uncharacterized protein
Search

OGT

0.91	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase subunit

0.80	GO:0006493	protein O-linked glycosylation
0.54	GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis
0.54	GO:0061087	positive regulation of histone H3-K27 methylation
0.53	GO:0043982	histone H4-K8 acetylation
0.53	GO:0043981	histone H4-K5 acetylation
0.53	GO:0035020	regulation of Rac protein signal transduction
0.53	GO:0080182	histone H3-K4 trimethylation
0.53	GO:0043984	histone H4-K16 acetylation
0.53	GO:0006110	regulation of glycolytic process
0.52	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.54	GO:0043996	histone acetyltransferase activity (H4-K8 specific)
0.54	GO:0046972	histone acetyltransferase activity (H4-K16 specific)
0.54	GO:0043995	histone acetyltransferase activity (H4-K5 specific)
0.52	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.43	GO:0140096	catalytic activity, acting on a protein
0.34	GO:0042277	peptide binding
0.34	GO:0019904	protein domain specific binding
0.34	GO:0048029	monosaccharide binding
0.33	GO:0008134	transcription factor binding

0.48	GO:0000123	histone acetyltransferase complex
0.45	GO:0005829	cytosol
0.41	GO:0043234	protein complex
0.40	GO:0005886	plasma membrane
0.35	GO:0042588	zymogen granule
0.34	GO:0000791	euchromatin
0.34	GO:0043025	neuronal cell body
0.34	GO:0043005	neuron projection
0.34	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.65

GO:0016757

tr|T1EDJ1|T1EDJ1_HELRO
Glycerol-3-phosphate dehydrogenase [NAD(+)]
Search

0.50	Glyceraldehyde-3-phosphate dehydrogenase

0.79	GO:0046168	glycerol-3-phosphate catabolic process
0.60	GO:0005975	carbohydrate metabolic process
0.53	GO:0055114	oxidation-reduction process
0.53	GO:0006734	NADH metabolic process
0.52	GO:0045821	positive regulation of glycolytic process
0.50	GO:0071320	cellular response to cAMP
0.49	GO:0071356	cellular response to tumor necrosis factor
0.45	GO:0042180	cellular ketone metabolic process
0.42	GO:0090038	negative regulation of protein kinase C signaling
0.42	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization

0.79	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity
0.75	GO:0042803	protein homodimerization activity
0.68	GO:0051287	NAD binding
0.41	GO:0017080	sodium channel regulator activity
0.41	GO:0044325	ion channel binding
0.38	GO:0004368	glycerol-3-phosphate dehydrogenase activity
0.34	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity

0.76	GO:0009331	glycerol-3-phosphate dehydrogenase complex
0.41	GO:0005739	mitochondrion
0.36	GO:0070062	extracellular exosome
0.36	GO:0005829	cytosol
0.36	GO:0031430	M band
0.36	GO:0030018	Z disc
0.35	GO:0005886	plasma membrane
0.34	GO:0071565	nBAF complex
0.34	GO:0071564	npBAF complex
0.34	GO:0016514	SWI/SNF complex

0.79	EC:1.1.1.8 EC:1.1.1.94	GO:0004367
0.79	KEGG:R00842	GO:0004367

tr|T1EDJ2|T1EDJ2_HELRO
Uncharacterized protein
Search

HSPA5

0.58	Heat shock 70 kDa protein cognate

0.54	GO:0021589	cerebellum structural organization
0.53	GO:0006987	activation of signaling protein activity involved in unfolded protein response
0.52	GO:0006983	ER overload response
0.51	GO:0071353	cellular response to interleukin-4
0.51	GO:0021680	cerebellar Purkinje cell layer development
0.51	GO:0035437	maintenance of protein localization in endoplasmic reticulum
0.50	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.50	GO:0042149	cellular response to glucose starvation
0.50	GO:0030335	positive regulation of cell migration
0.49	GO:0031398	positive regulation of protein ubiquitination

0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0051787	misfolded protein binding
0.49	GO:0045296	cadherin binding
0.48	GO:0031625	ubiquitin protein ligase binding
0.47	GO:0019904	protein domain specific binding
0.46	GO:0043022	ribosome binding
0.42	GO:0016887	ATPase activity

0.52	GO:0034663	endoplasmic reticulum chaperone complex
0.52	GO:0005788	endoplasmic reticulum lumen
0.50	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.49	GO:0030496	midbody
0.49	GO:0043209	myelin sheath
0.49	GO:0008180	COP9 signalosome
0.48	GO:0030176	integral component of endoplasmic reticulum membrane
0.47	GO:0009986	cell surface
0.40	GO:0042470	melanosome
0.40	GO:0005576	extracellular region

0.42	EC:3.6.1.3	GO:0016887
0.34	KEGG:R00036	GO:0004655

tr|T1EDJ3|T1EDJ3_HELRO
Uncharacterized protein
Search

0.30

GO:0008152

metabolic process

0.30

GO:0003824

catalytic activity

0.30

GO:0044425

membrane part

tr|T1EDJ4|T1EDJ4_HELRO
Uncharacterized protein
Search

CSDE1

0.84	Cold shock domain-containing protein E1

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.36	GO:0010605	negative regulation of macromolecule metabolic process
0.35	GO:0006401	RNA catabolic process
0.35	GO:0034249	negative regulation of cellular amide metabolic process
0.34	GO:0016071	mRNA metabolic process
0.34	GO:0031327	negative regulation of cellular biosynthetic process
0.34	GO:0034622	cellular macromolecular complex assembly
0.34	GO:0032268	regulation of cellular protein metabolic process

0.55	GO:0003677	DNA binding
0.35	GO:0003730	mRNA 3'-UTR binding

0.37	GO:0070937	CRD-mediated mRNA stability complex
0.35	GO:0005794	Golgi apparatus
0.34	GO:0005829	cytosol
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0019866	organelle inner membrane
0.33	GO:0005886	plasma membrane

tr|T1EDJ5|T1EDJ5_HELRO
Uncharacterized protein
Search

0.57	GO:0007160	cell-matrix adhesion
0.50	GO:0046626	regulation of insulin receptor signaling pathway
0.47	GO:0051260	protein homooligomerization
0.36	GO:0007219	Notch signaling pathway
0.35	GO:0030154	cell differentiation
0.34	GO:0050793	regulation of developmental process
0.34	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0007275	multicellular organism development
0.32	GO:2001141	regulation of RNA biosynthetic process

0.70	GO:0005509	calcium ion binding
0.46	GO:0042802	identical protein binding
0.34	GO:0004872	receptor activity
0.33	GO:0004871	signal transducer activity

0.67	GO:0005604	basement membrane
0.61	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1EDJ6|T1EDJ6_HELRO
Uncharacterized protein
Search

KDSR

0.93	3-ketodihydrosphingosine reductase

0.48	GO:0055114	oxidation-reduction process
0.48	GO:0006666	3-keto-sphinganine metabolic process
0.45	GO:0030148	sphingolipid biosynthetic process
0.35	GO:1904263	positive regulation of TORC1 signaling
0.33	GO:0015031	protein transport

0.49	GO:0016491	oxidoreductase activity
0.41	GO:0019904	protein domain specific binding
0.35	GO:0004312	fatty acid synthase activity
0.35	GO:0017056	structural constituent of nuclear pore

0.42	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane

0.49

GO:0016491

tr|T1EDJ7|T1EDJ7_HELRO
Palmitoyltransferase
Search

0.41	Palmitoyltransferase

0.42	GO:0018345	protein palmitoylation
0.36	GO:1903146	regulation of autophagy of mitochondrion
0.36	GO:1903955	positive regulation of protein targeting to mitochondrion
0.36	GO:0007626	locomotory behavior
0.33	GO:0055114	oxidation-reduction process

0.77	GO:0019706	protein-cysteine S-palmitoyltransferase activity
0.33	GO:0016491	oxidoreductase activity
0.33	GO:0003723	RNA binding

0.36	GO:0005794	Golgi apparatus
0.34	GO:0030659	cytoplasmic vesicle membrane
0.34	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.77

GO:0019706

tr|T1EDJ8|T1EDJ8_HELRO
Uncharacterized protein
Search

CLPB

0.86	caseinolytic peptidase B protein homolog

0.44

GO:0034605

cellular response to heat

0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0016887	ATPase activity
0.34	GO:0005515	protein binding

0.39	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.37

GO:0016887

tr|T1EDJ9|T1EDJ9_HELRO
Polypeptide N-acetylgalactosaminyltransferase
Search

0.62	Polypeptide N-acetylgalactosaminyltransferase

0.72	GO:0006486	protein glycosylation
0.47	GO:0018210	peptidyl-threonine modification
0.39	GO:0061314	Notch signaling involved in heart development
0.39	GO:0032504	multicellular organism reproduction
0.39	GO:0007220	Notch receptor processing
0.38	GO:0008593	regulation of Notch signaling pathway
0.38	GO:0007368	determination of left/right symmetry
0.37	GO:0060271	cilium assembly
0.36	GO:0006413	translational initiation
0.36	GO:0009312	oligosaccharide biosynthetic process

0.68	GO:0030246	carbohydrate binding
0.63	GO:0016757	transferase activity, transferring glycosyl groups
0.48	GO:0005112	Notch binding
0.40	GO:0140096	catalytic activity, acting on a protein
0.36	GO:0003743	translation initiation factor activity
0.34	GO:0046872	metal ion binding
0.34	GO:0030983	mismatched DNA binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.70	GO:0000139	Golgi membrane
0.40	GO:0031985	Golgi cisterna
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.63

GO:0016757

tr|T1EDK0|T1EDK0_HELRO
Uncharacterized protein
Search

MYO6

0.74	Unconventional myosin-VI

0.74	GO:0007018	microtubule-based movement
0.46	GO:0035479	angioblast cell migration from lateral mesoderm to midline
0.44	GO:0042491	inner ear auditory receptor cell differentiation
0.44	GO:0050974	detection of mechanical stimulus involved in sensory perception
0.44	GO:0048844	artery morphogenesis
0.35	GO:0051046	regulation of secretion
0.35	GO:0019749	cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte
0.35	GO:0030330	DNA damage response, signal transduction by p53 class mediator
0.35	GO:0030589	pseudocleavage involved in syncytial blastoderm formation
0.35	GO:0045175	basal protein localization

0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.74	GO:0003779	actin binding
0.71	GO:0032403	protein complex binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.35	GO:0070856	myosin VI light chain binding
0.34	GO:0000146	microfilament motor activity

0.77	GO:0016459	myosin complex
0.36	GO:0031941	filamentous actin
0.36	GO:0030139	endocytic vesicle
0.35	GO:0120025	plasma membrane bounded cell projection
0.35	GO:0070865	investment cone
0.35	GO:0045172	germline ring canal
0.34	GO:0045178	basal part of cell
0.34	GO:0031252	cell leading edge
0.34	GO:0031965	nuclear membrane
0.34	GO:0030136	clathrin-coated vesicle

0.34

GO:0016887

tr|T1EDK1|T1EDK1_HELRO
Uncharacterized protein
Search

0.72	Kv channel-interacting protein 1

0.36	GO:0045163	clustering of voltage-gated potassium channels
0.36	GO:0097623	potassium ion export across plasma membrane
0.36	GO:0086009	membrane repolarization
0.35	GO:1901379	regulation of potassium ion transmembrane transport
0.35	GO:0065009	regulation of molecular function
0.35	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.34	GO:0042981	regulation of apoptotic process
0.32	GO:0043043	peptide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process
0.32	GO:0010467	gene expression

0.70	GO:0005509	calcium ion binding
0.38	GO:0015459	potassium channel regulator activity
0.36	GO:0005250	A-type (transient outward) potassium channel activity
0.35	GO:0047485	protein N-terminus binding
0.35	GO:0044325	ion channel binding
0.33	GO:0003735	structural constituent of ribosome

0.36	GO:0008076	voltage-gated potassium channel complex
0.33	GO:0005737	cytoplasm
0.33	GO:0019866	organelle inner membrane
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0043231	intracellular membrane-bounded organelle
0.32	GO:0043232	intracellular non-membrane-bounded organelle

tr|T1EDK2|T1EDK2_HELRO
Uncharacterized protein
Search

0.60	Fibronectin type-III domain-containing protein 3a

0.42	GO:0098609	cell-cell adhesion
0.41	GO:0048513	animal organ development
0.40	GO:0030154	cell differentiation
0.40	GO:0007416	synapse assembly
0.40	GO:0046546	development of primary male sexual characteristics
0.39	GO:0009566	fertilization
0.39	GO:0007283	spermatogenesis
0.39	GO:0022412	cellular process involved in reproduction in multicellular organism
0.39	GO:0048608	reproductive structure development
0.38	GO:0060429	epithelium development

0.34	GO:0003723	RNA binding
0.33	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.32	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.40	GO:0001669	acrosomal vesicle
0.39	GO:0005794	Golgi apparatus
0.38	GO:0045202	synapse
0.38	GO:0012506	vesicle membrane
0.37	GO:0005829	cytosol
0.33	GO:0005886	plasma membrane
0.32	GO:0030054	cell junction
0.30	GO:0016021	integral component of membrane

0.33

GO:0004553

tr|T1EDK3|T1EDK3_HELRO
Uncharacterized protein
Search

0.22	Carboxylic ester hydrolase

0.39	GO:0097105	presynaptic membrane assembly
0.39	GO:0097104	postsynaptic membrane assembly
0.39	GO:0007158	neuron cell-cell adhesion
0.39	GO:0048488	synaptic vesicle endocytosis
0.38	GO:0050804	modulation of chemical synaptic transmission
0.35	GO:0006629	lipid metabolic process
0.35	GO:0043043	peptide biosynthetic process
0.34	GO:0044267	cellular protein metabolic process
0.34	GO:0010467	gene expression
0.34	GO:0009059	macromolecule biosynthetic process

0.48	GO:0052689	carboxylic ester hydrolase activity
0.41	GO:0042043	neurexin family protein binding
0.36	GO:0004872	receptor activity
0.36	GO:0003735	structural constituent of ribosome
0.33	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.33	GO:0020037	heme binding
0.33	GO:0005506	iron ion binding
0.33	GO:0004871	signal transducer activity

0.37	GO:0009986	cell surface
0.37	GO:0045202	synapse
0.37	GO:0034719	SMN-Sm protein complex
0.36	GO:0005887	integral component of plasma membrane
0.36	GO:0005576	extracellular region
0.35	GO:0005840	ribosome

0.48	EC:3.1.1 EC:3.1.1.1	GO:0052689
0.48	KEGG:R00630	GO:0052689

tr|T1EDK4|T1EDK4_HELRO
Uncharacterized protein
Search

0.82	Glycogen synthase kinase 3 alpha a

0.61	GO:0006468	protein phosphorylation
0.52	GO:0003007	heart morphogenesis
0.52	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development
0.52	GO:0036015	response to interleukin-3
0.52	GO:2000467	positive regulation of glycogen (starch) synthase activity
0.52	GO:0106071	positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.52	GO:0071879	positive regulation of adrenergic receptor signaling pathway
0.52	GO:0044027	hypermethylation of CpG island
0.51	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
0.50	GO:0071285	cellular response to lithium ion

0.65	GO:0004674	protein serine/threonine kinase activity
0.53	GO:0030554	adenyl nucleotide binding
0.52	GO:0097367	carbohydrate derivative binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0008144	drug binding
0.45	GO:0005102	receptor binding
0.42	GO:0050321	tau-protein kinase activity
0.40	GO:0034236	protein kinase A catalytic subunit binding
0.36	GO:0043565	sequence-specific DNA binding
0.36	GO:0003700	DNA binding transcription factor activity

0.41	GO:0005739	mitochondrion
0.37	GO:0030877	beta-catenin destruction complex
0.36	GO:0005634	nucleus
0.36	GO:0015630	microtubule cytoskeleton
0.36	GO:0044430	cytoskeletal part
0.35	GO:1990635	proximal dendrite
0.35	GO:0097440	apical dendrite
0.35	GO:0099512	supramolecular fiber
0.35	GO:0005829	cytosol
0.34	GO:0043025	neuronal cell body

0.65

GO:0004674

tr|T1EDK5|T1EDK5_HELRO
Uncharacterized protein
Search

IPO4

0.59	Importin-4

0.68	GO:0006886	intracellular protein transport
0.59	GO:0006335	DNA replication-dependent nucleosome assembly
0.56	GO:0006336	DNA replication-independent nucleosome assembly
0.52	GO:0006610	ribosomal protein import into nucleus
0.51	GO:0006607	NLS-bearing protein import into nucleus
0.34	GO:2000220	regulation of pseudohyphal growth
0.34	GO:0042254	ribosome biogenesis
0.33	GO:2001141	regulation of RNA biosynthetic process
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression

0.79	GO:0008536	Ran GTPase binding
0.50	GO:0008139	nuclear localization sequence binding
0.45	GO:0008565	protein transporter activity
0.34	GO:0043565	sequence-specific DNA binding
0.34	GO:0003700	DNA binding transcription factor activity

0.52	GO:0000790	nuclear chromatin
0.49	GO:0034399	nuclear periphery
0.48	GO:0031965	nuclear membrane
0.44	GO:0043234	protein complex
0.37	GO:0005737	cytoplasm
0.34	GO:0035770	ribonucleoprotein granule
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDK6|T1EDK6_HELRO
Receptor expression-enhancing protein
Search

0.69	Receptor expression-enhancing protein (Fragment)

0.37	GO:0050908	detection of light stimulus involved in visual perception
0.36	GO:0032386	regulation of intracellular transport
0.34	GO:1990809	endoplasmic reticulum tubular network membrane organization
0.34	GO:0032581	ER-dependent peroxisome organization
0.34	GO:0048309	endoplasmic reticulum inheritance
0.34	GO:0051292	nuclear pore complex assembly
0.33	GO:0034976	response to endoplasmic reticulum stress
0.33	GO:1901642	nucleoside transmembrane transport
0.33	GO:0006418	tRNA aminoacylation for protein translation
0.33	GO:0016192	vesicle-mediated transport

0.33	GO:0005337	nucleoside transmembrane transporter activity
0.33	GO:0016875	ligase activity, forming carbon-oxygen bonds
0.33	GO:0140101	catalytic activity, acting on a tRNA
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.37	GO:0044317	rod spherule
0.36	GO:0001917	photoreceptor inner segment
0.36	GO:0045177	apical part of cell
0.35	GO:0098827	endoplasmic reticulum subcompartment
0.35	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.33	GO:0044448	cell cortex part
0.33	GO:0032153	cell division site
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:6.1

GO:0016875

tr|T1EDK7|T1EDK7_HELRO
AMP deaminase
Search

AMPD2

0.69	AMP deaminase

0.77	GO:0032264	IMP salvage
0.51	GO:0097009	energy homeostasis
0.47	GO:0052652	cyclic purine nucleotide metabolic process
0.37	GO:0072015	glomerular visceral epithelial cell development
0.36	GO:0042632	cholesterol homeostasis
0.35	GO:0046039	GTP metabolic process
0.35	GO:0046033	AMP metabolic process
0.34	GO:0046034	ATP metabolic process

0.81	GO:0003876	AMP deaminase activity
0.50	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.44

GO:0005829

cytosol

0.81

EC:3.5.4.6

GO:0003876

tr|T1EDK8|T1EDK8_HELRO
Uncharacterized protein
Search

0.95	Histone H3 domain-containing protein

0.41	GO:0006334	nucleosome assembly
0.39	GO:0051382	kinetochore assembly
0.38	GO:0000070	mitotic sister chromatid segregation
0.38	GO:0061641	CENP-A containing chromatin organization
0.37	GO:0046689	response to mercury ion
0.33	GO:0055114	oxidation-reduction process

0.73	GO:0046982	protein heterodimerization activity
0.54	GO:0003677	DNA binding
0.41	GO:0031491	nucleosome binding
0.33	GO:0016491	oxidoreductase activity

0.73	GO:0000786	nucleosome
0.60	GO:0005634	nucleus
0.40	GO:0000775	chromosome, centromeric region
0.36	GO:0000793	condensed chromosome
0.35	GO:0043234	protein complex
0.35	GO:0031974	membrane-enclosed lumen

0.33

GO:0016491

tr|T1EDK9|T1EDK9_HELRO
Uncharacterized protein
Search

0.46	Putative E3 ubiquitin-protein ligase HERC1

0.73	GO:0016567	protein ubiquitination
0.39	GO:0021702	cerebellar Purkinje cell differentiation
0.38	GO:0050885	neuromuscular process controlling balance
0.37	GO:0031175	neuron projection development
0.37	GO:0010507	negative regulation of autophagy
0.35	GO:0065009	regulation of molecular function

0.73	GO:0004842	ubiquitin-protein transferase activity
0.62	GO:0016874	ligase activity
0.38	GO:0005086	ARF guanyl-nucleotide exchange factor activity

0.36	GO:0005794	Golgi apparatus
0.36	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.62	EC:6	GO:0016874
0.73	KEGG:R03876	GO:0004842

tr|T1EDL0|T1EDL0_HELRO
Uncharacterized protein
Search

INTS14

0.96	von Willebrand factor A domain-containing protein 9

0.47	GO:0042795	snRNA transcription by RNA polymerase II
0.35	GO:0006468	protein phosphorylation

0.35	GO:0004672	protein kinase activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.52	GO:0005634	nucleus
0.41	GO:0031974	membrane-enclosed lumen
0.38	GO:0044446	intracellular organelle part
0.38	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EDL1|T1EDL1_HELRO
Uncharacterized protein
Search

0.11	Transforming acidic coiled-coil-containing protein 1

0.76	GO:0008283	cell proliferation
0.73	GO:0000226	microtubule cytoskeleton organization
0.56	GO:0021987	cerebral cortex development
0.51	GO:0042073	intraciliary transport

0.68	GO:0015630	microtubule cytoskeleton
0.48	GO:0005929	cilium
0.47	GO:0005737	cytoplasm

tr|T1EDL2|T1EDL2_HELRO
Uncharacterized protein
Search

0.48	GO:0032259	methylation
0.47	GO:0070544	histone H3-K36 demethylation
0.46	GO:0034721	histone H3-K4 demethylation, trimethyl-H3-K4-specific
0.45	GO:0007526	larval somatic muscle development
0.45	GO:0007379	segment specification
0.45	GO:0033522	histone H2A ubiquitination
0.37	GO:0006303	double-strand break repair via nonhomologous end joining
0.34	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:1903506	regulation of nucleic acid-templated transcription

0.61	GO:0008270	zinc ion binding
0.53	GO:0003677	DNA binding
0.49	GO:0008168	methyltransferase activity
0.46	GO:0032452	histone demethylase activity
0.38	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
0.34	GO:0005506	iron ion binding
0.34	GO:0004842	ubiquitin-protein transferase activity

0.59	GO:0005634	nucleus
0.38	GO:0043234	protein complex
0.37	GO:0044446	intracellular organelle part
0.34	GO:0019005	SCF ubiquitin ligase complex
0.33	GO:0031974	membrane-enclosed lumen
0.30	GO:0031224	intrinsic component of membrane

0.49	EC:2.1.1	GO:0008168
0.34	KEGG:R03876	GO:0004842

tr|T1EDL3|T1EDL3_HELRO
Uncharacterized protein
Search

0.53	Spermine synthase

0.85

GO:0006597

spermine biosynthetic process

0.86

GO:0016768

spermine synthase activity

0.86

EC:2.5.1.22

GO:0016768

tr|T1EDL4|T1EDL4_HELRO
Uncharacterized protein
Search

tr|T1EDL5|T1EDL5_HELRO
Uncharacterized protein
Search

0.44	RNA helicase

0.50	GO:0010501	RNA secondary structure unwinding
0.48	GO:0007286	spermatid development
0.47	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.47	GO:0008380	RNA splicing
0.47	GO:0051028	mRNA transport
0.45	GO:0006405	RNA export from nucleus
0.44	GO:0006417	regulation of translation
0.38	GO:0006413	translational initiation
0.35	GO:0007275	multicellular organism development
0.34	GO:0010043	response to zinc ion

0.59	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0008186	RNA-dependent ATPase activity
0.51	GO:0003676	nucleic acid binding
0.45	GO:0140098	catalytic activity, acting on RNA
0.34	GO:0005515	protein binding
0.33	GO:0003700	DNA binding transcription factor activity

0.50	GO:0033391	chromatoid body
0.50	GO:0071013	catalytic step 2 spliceosome
0.47	GO:0005730	nucleolus
0.37	GO:0005635	nuclear envelope
0.37	GO:0070062	extracellular exosome
0.35	GO:0031090	organelle membrane
0.34	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

tr|T1EDL6|T1EDL6_HELRO
Uncharacterized protein
Search

TGDS

0.41	dTDP-D-glucose 4,6-dehydratase

0.41	GO:1902223	erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process
0.41	GO:0009225	nucleotide-sugar metabolic process
0.41	GO:0006558	L-phenylalanine metabolic process
0.41	GO:0009095	aromatic amino acid family biosynthetic process, prephenate pathway
0.38	GO:0022900	electron transport chain

0.64	GO:0008460	dTDP-glucose 4,6-dehydratase activity
0.54	GO:0050377	UDP-glucose 4,6-dehydratase activity
0.43	GO:0050662	coenzyme binding
0.41	GO:0004664	prephenate dehydratase activity
0.40	GO:0051537	2 iron, 2 sulfur cluster binding
0.39	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
0.38	GO:0009055	electron transfer activity
0.37	GO:0003723	RNA binding
0.36	GO:0046872	metal ion binding
0.36	GO:0043168	anion binding

0.30

GO:0031224

intrinsic component of membrane

0.64	EC:4.2.1.46	GO:0008460
0.64	KEGG:R06513	GO:0008460

tr|T1EDL7|T1EDL7_HELRO
Uncharacterized protein
Search

0.57	UBX domain-containing protein 6

tr|T1EDL8|T1EDL8_HELRO
Uncharacterized protein
Search

SCD5

0.52	Stearoyl-CoA desaturase b

0.69	GO:0006633	fatty acid biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.49	GO:0033559	unsaturated fatty acid metabolic process
0.33	GO:0001510	RNA methylation
0.33	GO:0006396	RNA processing

0.80	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
0.35	GO:0005506	iron ion binding
0.33	GO:0008173	RNA methyltransferase activity

0.42	GO:0005789	endoplasmic reticulum membrane
0.37	GO:0005730	nucleolus
0.30	GO:0016021	integral component of membrane

0.80

EC:1.14.19

GO:0016717

tr|T1EDL9|T1EDL9_HELRO
Uncharacterized protein
Search

GLIPR1

0.53	Glioma pathogenesis-related protein 1

0.36	GO:0007229	integrin-mediated signaling pathway
0.35	GO:0043312	neutrophil degranulation
0.34	GO:0007338	single fertilization
0.34	GO:0019216	regulation of lipid metabolic process

0.33

GO:0046872

metal ion binding

0.66	GO:0005576	extracellular region
0.36	GO:0030141	secretory granule
0.35	GO:0005766	primary lysosome
0.35	GO:0098805	whole membrane
0.34	GO:0097223	sperm part
0.34	GO:0031225	anchored component of membrane
0.34	GO:0030659	cytoplasmic vesicle membrane
0.34	GO:0044437	vacuolar part
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0005886	plasma membrane

tr|T1EDM0|T1EDM0_HELRO
Poly [ADP-ribose] polymerase
Search

0.37	Poly [ADP-ribose] polymerase

0.40	GO:0006471	protein ADP-ribosylation
0.38	GO:0045071	negative regulation of viral genome replication
0.38	GO:0061014	positive regulation of mRNA catabolic process
0.36	GO:0009615	response to virus
0.34	GO:0006273	lagging strand elongation
0.34	GO:0051103	DNA ligation involved in DNA repair

0.82	GO:0003950	NAD+ ADP-ribosyltransferase activity
0.44	GO:0046872	metal ion binding
0.42	GO:0003723	RNA binding
0.37	GO:0045296	cadherin binding
0.34	GO:0003910	DNA ligase (ATP) activity

0.35	GO:0005829	cytosol
0.32	GO:0005634	nucleus

0.82

EC:2.4.2.30

GO:0003950

tr|T1EDM1|T1EDM1_HELRO
Uncharacterized protein
Search

0.20	Receptor-type tyrosine-protein phosphatase U (Fragment)

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.45	GO:0008045	motor neuron axon guidance
0.45	GO:0007424	open tracheal system development
0.43	GO:0034394	protein localization to cell surface
0.43	GO:0007417	central nervous system development
0.42	GO:0030336	negative regulation of cell migration
0.41	GO:0008285	negative regulation of cell proliferation
0.41	GO:0048041	focal adhesion assembly
0.41	GO:0010837	regulation of keratinocyte proliferation
0.40	GO:0034644	cellular response to UV

0.75	GO:0004725	protein tyrosine phosphatase activity
0.42	GO:0008013	beta-catenin binding
0.41	GO:0045295	gamma-catenin binding
0.41	GO:0019198	transmembrane receptor protein phosphatase activity
0.39	GO:0019901	protein kinase binding

0.46	GO:0043025	neuronal cell body
0.46	GO:0030424	axon
0.44	GO:0016324	apical plasma membrane
0.41	GO:0030054	cell junction
0.40	GO:0001750	photoreceptor outer segment
0.40	GO:0031256	leading edge membrane
0.39	GO:0030425	dendrite
0.38	GO:0009986	cell surface
0.35	GO:0043227	membrane-bounded organelle
0.34	GO:0043229	intracellular organelle

0.75

GO:0004725

tr|T1EDM2|T1EDM2_HELRO
Uncharacterized protein
Search

tr|T1EDM3|T1EDM3_HELRO
Uncharacterized protein
Search

TEKT2

0.64

Tektin-2

0.86	GO:0060294	cilium movement involved in cell motility
0.85	GO:0030317	flagellated sperm motility
0.79	GO:0060271	cilium assembly

0.85	GO:0036126	sperm flagellum
0.61	GO:0005634	nucleus
0.55	GO:0005874	microtubule
0.41	GO:0005737	cytoplasm

tr|T1EDM4|T1EDM4_HELRO
Uncharacterized protein
Search

0.94	Calcium-regulated heat stable protein 1

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.49	GO:1903311	regulation of mRNA metabolic process
0.48	GO:0031329	regulation of cellular catabolic process
0.44	GO:0065008	regulation of biological quality
0.41	GO:0002100	tRNA wobble adenosine to inosine editing
0.35	GO:0006397	mRNA processing
0.34	GO:0019722	calcium-mediated signaling
0.32	GO:0055114	oxidation-reduction process

0.55	GO:0003677	DNA binding
0.53	GO:0003730	mRNA 3'-UTR binding
0.41	GO:0008251	tRNA-specific adenosine deaminase activity
0.35	GO:0008134	transcription factor binding
0.34	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
0.34	GO:0019902	phosphatase binding
0.34	GO:0003950	NAD+ ADP-ribosyltransferase activity
0.33	GO:0005507	copper ion binding

0.48	GO:0043186	P granule
0.48	GO:0000177	cytoplasmic exosome (RNase complex)
0.42	GO:0005829	cytosol
0.36	GO:0000932	P-body
0.35	GO:0070062	extracellular exosome
0.34	GO:0005634	nucleus

0.41

EC:3.5.4

GO:0008251

tr|T1EDM5|T1EDM5_HELRO
Uncharacterized protein
Search

tr|T1EDM6|T1EDM6_HELRO
Uncharacterized protein
Search

0.51	WD repeat-containing protein 36

0.68	GO:0006364	rRNA processing
0.40	GO:0001895	retina homeostasis
0.40	GO:0030516	regulation of axon extension
0.34	GO:0016573	histone acetylation

0.34	GO:0004402	histone acetyltransferase activity
0.32	GO:0016787	hydrolase activity

0.78	GO:0032040	small-subunit processome
0.46	GO:0005730	nucleolus
0.44	GO:0030686	90S preribosome
0.38	GO:0043234	protein complex
0.35	GO:0005737	cytoplasm

0.34

GO:0004402

tr|T1EDM7|T1EDM7_HELRO
Uncharacterized protein
Search

0.40	DEAD box ATP-dependent RNA helicase

0.48	GO:0033962	cytoplasmic mRNA processing body assembly
0.46	GO:0090328	regulation of olfactory learning
0.45	GO:0007279	pole cell formation
0.45	GO:0046959	habituation
0.44	GO:0050688	regulation of defense response to virus
0.43	GO:0030707	ovarian follicle cell development
0.43	GO:0035195	gene silencing by miRNA
0.43	GO:0006413	translational initiation
0.40	GO:0010501	RNA secondary structure unwinding
0.36	GO:0008340	determination of adult lifespan

0.67	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.39	GO:0008186	RNA-dependent ATPase activity
0.36	GO:0140098	catalytic activity, acting on RNA
0.33	GO:0005515	protein binding

0.46	GO:0000932	P-body
0.45	GO:0043186	P granule
0.41	GO:0010494	cytoplasmic stress granule
0.38	GO:0005730	nucleolus
0.36	GO:1990124	messenger ribonucleoprotein complex

tr|T1EDM8|T1EDM8_HELRO
Uncharacterized protein
Search

SNW1

0.95	SNW domain-containing protein 1

0.75	GO:0000398	mRNA splicing, via spliceosome
0.47	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
0.47	GO:0006357	regulation of transcription by RNA polymerase II
0.46	GO:0090287	regulation of cellular response to growth factor stimulus
0.46	GO:0014029	neural crest formation
0.44	GO:0022618	ribonucleoprotein complex assembly
0.40	GO:0070562	regulation of vitamin D receptor signaling pathway
0.40	GO:0048385	regulation of retinoic acid receptor signaling pathway
0.40	GO:0051571	positive regulation of histone H3-K4 methylation
0.40	GO:0048026	positive regulation of mRNA splicing, via spliceosome

0.45	GO:0003712	transcription cofactor activity
0.40	GO:0042809	vitamin D receptor binding
0.40	GO:0042974	retinoic acid receptor binding
0.39	GO:0046332	SMAD binding
0.38	GO:0050681	androgen receptor binding
0.37	GO:0005112	Notch binding
0.36	GO:0019899	enzyme binding
0.33	GO:0003723	RNA binding

0.76	GO:0005681	spliceosomal complex
0.50	GO:0071141	SMAD protein complex
0.46	GO:0005654	nucleoplasm
0.41	GO:1902494	catalytic complex
0.39	GO:0016363	nuclear matrix
0.36	GO:0000974	Prp19 complex
0.36	GO:0000785	chromatin
0.33	GO:0005737	cytoplasm

tr|T1EDM9|T1EDM9_HELRO
Uncharacterized protein
Search

0.80	Small nuclear ribonucleoprotein Sm D3

0.81	GO:0000387	spliceosomal snRNP assembly
0.42	GO:0000245	spliceosomal complex assembly
0.36	GO:0008213	protein alkylation
0.35	GO:0043414	macromolecule methylation

0.38	GO:0071208	histone pre-mRNA DCP binding
0.38	GO:0071209	U7 snRNA binding
0.38	GO:0030620	U2 snRNA binding
0.38	GO:0070034	telomerase RNA binding
0.35	GO:0019899	enzyme binding

0.76	GO:0005681	spliceosomal complex
0.62	GO:0019013	viral nucleocapsid
0.45	GO:0005687	U4 snRNP
0.45	GO:0034715	pICln-Sm protein complex
0.45	GO:0034719	SMN-Sm protein complex
0.43	GO:0005685	U1 snRNP
0.43	GO:0005682	U5 snRNP
0.43	GO:0005686	U2 snRNP
0.42	GO:0097526	spliceosomal tri-snRNP complex
0.38	GO:1902494	catalytic complex

tr|T1EDN0|T1EDN0_HELRO
Protein disulfide-isomerase
Search

P4HB

0.48	Protein disulfide-isomerase

0.68	GO:0045454	cell redox homeostasis
0.54	GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
0.52	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
0.52	GO:0046598	positive regulation of viral entry into host cell
0.50	GO:0034976	response to endoplasmic reticulum stress
0.49	GO:0071456	cellular response to hypoxia
0.41	GO:0006457	protein folding
0.40	GO:0055114	oxidation-reduction process
0.35	GO:0034378	chylomicron assembly
0.35	GO:0038155	interleukin-23-mediated signaling pathway

0.81	GO:0003756	protein disulfide isomerase activity
0.52	GO:0031545	peptidyl-proline 4-dioxygenase activity
0.50	GO:0019798	procollagen-proline dioxygenase activity
0.50	GO:0005178	integrin binding
0.48	GO:0015037	peptide disulfide oxidoreductase activity
0.47	GO:0046982	protein heterodimerization activity
0.36	GO:0019899	enzyme binding
0.33	GO:0003723	RNA binding
0.33	GO:0004674	protein serine/threonine kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding

0.70	GO:0005783	endoplasmic reticulum
0.49	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.49	GO:0009897	external side of plasma membrane
0.44	GO:1990204	oxidoreductase complex
0.42	GO:0042470	melanosome
0.42	GO:0044446	intracellular organelle part
0.41	GO:0043234	protein complex
0.38	GO:0043233	organelle lumen
0.38	GO:0060187	cell pole
0.37	GO:0044421	extracellular region part

0.81

EC:5.3.4.1

GO:0003756

tr|T1EDN1|T1EDN1_HELRO
Uncharacterized protein
Search

tr|T1EDN2|T1EDN2_HELRO
Arginyl-tRNA--protein transferase 1
Search

0.41	Arginyl-tRNA--protein transferase 1

0.82	GO:0016598	protein arginylation
0.42	GO:0010498	proteasomal protein catabolic process

0.82	GO:0004057	arginyltransferase activity
0.33	GO:0005515	protein binding

0.38	GO:0005634	nucleus
0.36	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.82

EC:2.3.2.8

GO:0004057

tr|T1EDN3|T1EDN3_HELRO
Uncharacterized protein
Search

POLR2G

0.73	DNA-directed RNA polymerase subunit E

0.58	GO:0006351	transcription, DNA-templated
0.49	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
0.48	GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic
0.47	GO:0045948	positive regulation of translational initiation
0.37	GO:0006465	signal peptide processing
0.36	GO:0006915	apoptotic process
0.35	GO:0051090	regulation of DNA binding transcription factor activity
0.35	GO:0035019	somatic stem cell population maintenance
0.34	GO:0060964	regulation of gene silencing by miRNA
0.34	GO:0008543	fibroblast growth factor receptor signaling pathway

0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.51	GO:0003676	nucleic acid binding
0.47	GO:0031369	translation initiation factor binding
0.36	GO:0017171	serine hydrolase activity
0.35	GO:0070011	peptidase activity, acting on L-amino acid peptides
0.35	GO:0046982	protein heterodimerization activity

0.53	GO:0005665	DNA-directed RNA polymerase II, core complex
0.47	GO:0000932	P-body
0.38	GO:0005787	signal peptidase complex
0.36	GO:0046695	SLIK (SAGA-like) complex
0.35	GO:0000124	SAGA complex
0.35	GO:0005669	transcription factor TFIID complex
0.30	GO:0031224	intrinsic component of membrane

0.70

GO:0003899

tr|T1EDN4|T1EDN4_HELRO
Malate dehydrogenase
Search

MDH2

0.45	Malate dehydrogenase, mitochondrial

0.77	GO:0006108	malate metabolic process
0.70	GO:0006099	tricarboxylic acid cycle
0.60	GO:0005975	carbohydrate metabolic process
0.48	GO:0006475	internal protein amino acid acetylation
0.38	GO:0006734	NADH metabolic process
0.38	GO:0006107	oxaloacetate metabolic process
0.37	GO:0001300	chronological cell aging
0.37	GO:0001302	replicative cell aging
0.32	GO:0044283	small molecule biosynthetic process
0.32	GO:1901576	organic substance biosynthetic process

0.78	GO:0030060	L-malate dehydrogenase activity
0.39	GO:0046554	malate dehydrogenase (NADP+) activity
0.38	GO:0043621	protein self-association
0.38	GO:0042803	protein homodimerization activity
0.36	GO:0003729	mRNA binding
0.34	GO:0051087	chaperone binding

0.48	GO:0043209	myelin sheath
0.42	GO:0044429	mitochondrial part
0.41	GO:0019866	organelle inner membrane
0.39	GO:0031974	membrane-enclosed lumen
0.35	GO:0070062	extracellular exosome
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.78	EC:1.1.1.37	GO:0030060
0.39	KEGG:R00343	GO:0046554

tr|T1EDN5|T1EDN5_HELRO
Uncharacterized protein
Search

SLC25A11

0.53	Mitochondrial 2-oxoglutarate/malate carrier protein isoform 1

0.57	GO:0006839	mitochondrial transport
0.50	GO:0015742	alpha-ketoglutarate transport
0.34	GO:0042276	error-prone translesion synthesis
0.34	GO:0030488	tRNA methylation
0.34	GO:0019319	hexose biosynthetic process
0.33	GO:0006006	glucose metabolic process
0.33	GO:0006508	proteolysis
0.32	GO:0055085	transmembrane transport

0.50	GO:0015367	oxoglutarate:malate antiporter activity
0.34	GO:0016429	tRNA (adenine-N1-)-methyltransferase activity
0.34	GO:0003779	actin binding
0.33	GO:0003723	RNA binding
0.33	GO:0004222	metalloendopeptidase activity
0.33	GO:0003684	damaged DNA binding
0.33	GO:0016779	nucleotidyltransferase activity

0.50	GO:0031966	mitochondrial membrane
0.44	GO:0019866	organelle inner membrane
0.34	GO:0005634	nucleus
0.34	GO:0031515	tRNA (m1A) methyltransferase complex
0.33	GO:0019013	viral nucleocapsid
0.33	GO:0005887	integral component of plasma membrane
0.33	GO:0030529	intracellular ribonucleoprotein complex

0.34

GO:0016429

tr|T1EDN6|T1EDN6_HELRO
Uncharacterized protein
Search

0.53	Zinc finger protein 366

0.59	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
0.57	GO:0043627	response to estrogen
0.53	GO:0000122	negative regulation of transcription by RNA polymerase II
0.34	GO:0040034	regulation of development, heterochronic
0.33	GO:0006351	transcription, DNA-templated
0.32	GO:0015074	DNA integration

0.58	GO:0030331	estrogen receptor binding
0.54	GO:0003714	transcription corepressor activity
0.51	GO:0003676	nucleic acid binding
0.36	GO:0046872	metal ion binding
0.34	GO:0003700	DNA binding transcription factor activity

0.46	GO:0005634	nucleus
0.34	GO:0000792	heterochromatin
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDN7|T1EDN7_HELRO
Uncharacterized protein
Search

0.44	Small GTP-binding protein of Rab family

0.41	GO:0060471	cortical granule exocytosis
0.41	GO:0090068	positive regulation of cell cycle process
0.40	GO:0030703	eggshell formation
0.39	GO:1903023	regulation of ascospore-type prospore membrane assembly
0.39	GO:0051781	positive regulation of cell division
0.39	GO:1990896	protein localization to cell cortex of cell tip
0.39	GO:1902441	protein localization to meiotic spindle pole body
0.39	GO:0009792	embryo development ending in birth or egg hatching
0.38	GO:0032465	regulation of cytokinesis
0.38	GO:0051446	positive regulation of meiotic cell cycle

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0004674	protein serine/threonine kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0008144	drug binding

0.41	GO:0055037	recycling endosome
0.41	GO:0060473	cortical granule
0.39	GO:0090619	meiotic spindle pole
0.39	GO:0090726	cortical dynamic polarity patch
0.37	GO:0005628	prospore membrane
0.34	GO:0016324	apical plasma membrane
0.34	GO:0010008	endosome membrane
0.34	GO:0030133	transport vesicle
0.34	GO:0005815	microtubule organizing center
0.34	GO:0000139	Golgi membrane

0.33

GO:0004674

tr|T1EDN8|T1EDN8_HELRO
Uncharacterized protein
Search

HTR1F

0.81	Candidate serotonin receptor

0.80	GO:0098664	G-protein coupled serotonin receptor signaling pathway
0.65	GO:0042310	vasoconstriction
0.65	GO:0050795	regulation of behavior
0.62	GO:0046883	regulation of hormone secretion
0.61	GO:0008283	cell proliferation
0.60	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.48	GO:0014062	regulation of serotonin secretion
0.47	GO:0042053	regulation of dopamine metabolic process
0.47	GO:0042428	serotonin metabolic process
0.46	GO:0035640	exploration behavior

0.80	GO:0099589	serotonin receptor activity
0.77	GO:0099528	G-protein coupled neurotransmitter receptor activity
0.77	GO:0008227	G-protein coupled amine receptor activity
0.58	GO:0051378	serotonin binding
0.48	GO:0090722	receptor-receptor interaction
0.34	GO:0001965	G-protein alpha-subunit binding
0.32	GO:0008144	drug binding

0.62	GO:0005887	integral component of plasma membrane
0.37	GO:0043025	neuronal cell body
0.37	GO:0043005	neuron projection
0.37	GO:0120038	plasma membrane bounded cell projection part
0.37	GO:0005791	rough endoplasmic reticulum
0.35	GO:0005794	Golgi apparatus

tr|T1EDN9|T1EDN9_HELRO
Uncharacterized protein
Search

tr|T1EDP0|T1EDP0_HELRO
Uncharacterized protein
Search

0.10	PR domain zinc finger protein 14

0.53	GO:0034972	histone H3-R26 methylation
0.51	GO:1902459	positive regulation of stem cell population maintenance
0.51	GO:0060817	inactivation of paternal X chromosome
0.51	GO:1902093	positive regulation of flagellated sperm motility
0.51	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
0.50	GO:0044030	regulation of DNA methylation
0.50	GO:0048873	homeostasis of number of cells within a tissue
0.50	GO:0001827	inner cell mass cell fate commitment
0.50	GO:0030718	germ-line stem cell population maintenance
0.50	GO:0048468	cell development

0.51	GO:0003676	nucleic acid binding
0.46	GO:0003682	chromatin binding
0.34	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
0.34	GO:0035257	nuclear hormone receptor binding
0.33	GO:0008168	methyltransferase activity
0.33	GO:0046872	metal ion binding
0.33	GO:0046983	protein dimerization activity
0.33	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.32	GO:0005215	transporter activity

0.45	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0008168

tr|T1EDP1|T1EDP1_HELRO
Uncharacterized protein
Search

PGM2

0.44	Phosphoglucomutase / phosphopentomutase

0.60	GO:0005975	carbohydrate metabolic process
0.34	GO:0016573	histone acetylation
0.33	GO:0044281	small molecule metabolic process
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.74	GO:0016868	intramolecular transferase activity, phosphotransferases
0.64	GO:0000287	magnesium ion binding
0.34	GO:0004402	histone acetyltransferase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.39	GO:0005829	cytosol
0.33	GO:0005634	nucleus

0.74

EC:5.4.2

GO:0016868

tr|T1EDP2|T1EDP2_HELRO
Guanylate cyclase
Search

0.26	Guanylate cyclase

0.77	GO:0006182	cGMP biosynthetic process
0.63	GO:0035556	intracellular signal transduction
0.59	GO:0006468	protein phosphorylation
0.37	GO:0018212	peptidyl-tyrosine modification
0.36	GO:0007168	receptor guanylyl cyclase signaling pathway
0.36	GO:0060038	cardiac muscle cell proliferation

0.77	GO:0004383	guanylate cyclase activity
0.59	GO:0004672	protein kinase activity
0.53	GO:1901265	nucleoside phosphate binding
0.51	GO:0036094	small molecule binding
0.51	GO:0097367	carbohydrate derivative binding
0.51	GO:0008144	drug binding
0.50	GO:0043168	anion binding
0.40	GO:0004016	adenylate cyclase activity
0.36	GO:0016941	natriuretic peptide receptor activity

0.45	GO:0005622	intracellular
0.36	GO:0043234	protein complex
0.35	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.77

GO:0004383

tr|T1EDP3|T1EDP3_HELRO
Uncharacterized protein
Search

0.76	GO:0016579	protein deubiquitination
0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.41	GO:0043153	entrainment of circadian clock by photoperiod
0.41	GO:0045475	locomotor rhythm
0.41	GO:0032922	circadian regulation of gene expression
0.40	GO:0045931	positive regulation of mitotic cell cycle
0.40	GO:0050821	protein stabilization
0.39	GO:0000122	negative regulation of transcription by RNA polymerase II
0.36	GO:0006888	ER to Golgi vesicle-mediated transport
0.34	GO:0032446	protein modification by small protein conjugation

0.76	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.40	GO:0030332	cyclin binding
0.39	GO:0031625	ubiquitin protein ligase binding
0.38	GO:0042802	identical protein binding
0.34	GO:0008852	exodeoxyribonuclease I activity
0.34	GO:0046872	metal ion binding
0.34	GO:0019787	ubiquitin-like protein transferase activity
0.33	GO:0031624	ubiquitin conjugating enzyme binding
0.32	GO:0016874	ligase activity

0.41	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0005938	cell cortex
0.36	GO:0005634	nucleus
0.34	GO:0030127	COPII vesicle coat
0.33	GO:0000151	ubiquitin ligase complex

0.76

GO:0036459

tr|T1EDP4|T1EDP4_HELRO
Uncharacterized protein
Search

0.61	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1

0.52	GO:0055114	oxidation-reduction process
0.51	GO:0009257	10-formyltetrahydrofolate biosynthetic process
0.46	GO:0001780	neutrophil homeostasis
0.45	GO:0019346	transsulfuration
0.44	GO:0001843	neural tube closure
0.44	GO:0061053	somite development
0.43	GO:0007507	heart development
0.43	GO:0009113	purine nucleobase biosynthetic process
0.42	GO:0035999	tetrahydrofolate interconversion
0.41	GO:0009086	methionine biosynthetic process

0.81	GO:0004329	formate-tetrahydrofolate ligase activity
0.78	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity
0.44	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity
0.36	GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
0.34	GO:0004888	transmembrane signaling receptor activity
0.32	GO:0005515	protein binding

0.40	GO:0005829	cytosol
0.38	GO:0005739	mitochondrion
0.35	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.81	EC:6.3.4.3	GO:0004329
0.78	KEGG:R01220	GO:0004488

tr|T1EDP5|T1EDP5_HELRO
Uncharacterized protein
Search

0.43	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

0.53	GO:0055114	oxidation-reduction process
0.38	GO:0016310	phosphorylation
0.37	GO:0046034	ATP metabolic process
0.37	GO:0006091	generation of precursor metabolites and energy
0.36	GO:0036211	protein modification process
0.35	GO:0044267	cellular protein metabolic process
0.34	GO:0032981	mitochondrial respiratory chain complex I assembly
0.34	GO:0046470	phosphatidylcholine metabolic process
0.34	GO:0006370	7-methylguanosine mRNA capping
0.33	GO:0016042	lipid catabolic process

0.70	GO:0010181	FMN binding
0.69	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.67	GO:0051539	4 iron, 4 sulfur cluster binding
0.66	GO:0051287	NAD binding
0.52	GO:0046872	metal ion binding
0.36	GO:0004672	protein kinase activity
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0004484	mRNA guanylyltransferase activity
0.34	GO:0032555	purine ribonucleotide binding
0.34	GO:0008144	drug binding

0.60	GO:0070469	respiratory chain
0.60	GO:0031966	mitochondrial membrane
0.60	GO:0019866	organelle inner membrane
0.41	GO:0030964	NADH dehydrogenase complex
0.40	GO:0098798	mitochondrial protein complex
0.39	GO:0005829	cytosol
0.39	GO:1990204	oxidoreductase complex
0.37	GO:0098796	membrane protein complex
0.30	GO:0031224	intrinsic component of membrane

0.69

EC:1.6.5.3

GO:0008137

tr|T1EDP6|T1EDP6_HELRO
Casein kinase II subunit beta
Search

CSNK2B

0.59	Casein kinase II subunit beta

0.76	GO:0045859	regulation of protein kinase activity
0.51	GO:0033211	adiponectin-activated signaling pathway
0.50	GO:0032927	positive regulation of activin receptor signaling pathway
0.50	GO:0016310	phosphorylation
0.50	GO:0061154	endothelial tube morphogenesis
0.49	GO:0043537	negative regulation of blood vessel endothelial cell migration
0.49	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.48	GO:0018210	peptidyl-threonine modification
0.41	GO:0016055	Wnt signaling pathway
0.38	GO:0097421	liver regeneration

0.79	GO:0019887	protein kinase regulator activity
0.52	GO:0016301	kinase activity
0.46	GO:0003682	chromatin binding
0.46	GO:0019904	protein domain specific binding
0.45	GO:0042802	identical protein binding
0.44	GO:0008134	transcription factor binding
0.44	GO:0005102	receptor binding
0.41	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.39	GO:0140096	catalytic activity, acting on a protein
0.36	GO:0043021	ribonucleoprotein complex binding

0.83	GO:0005956	protein kinase CK2 complex
0.49	GO:0031519	PcG protein complex
0.39	GO:0005886	plasma membrane
0.37	GO:0016363	nuclear matrix
0.37	GO:0005737	cytoplasm
0.36	GO:0005929	cilium
0.36	GO:0000785	chromatin
0.36	GO:0070062	extracellular exosome
0.35	GO:0031983	vesicle lumen
0.33	GO:0097708	intracellular vesicle

0.41

GO:0016773

tr|T1EDP7|T1EDP7_HELRO
Uncharacterized protein
Search

0.53	GO:0055114	oxidation-reduction process
0.42	GO:0019369	arachidonic acid metabolic process
0.35	GO:0009410	response to xenobiotic stimulus
0.34	GO:0009809	lignin biosynthetic process
0.33	GO:0042343	indole glucosinolate metabolic process
0.33	GO:0070836	caveola assembly
0.33	GO:0042572	retinol metabolic process
0.33	GO:0008202	steroid metabolic process
0.32	GO:0098542	defense response to other organism
0.32	GO:0006313	transposition, DNA-mediated

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.66	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.32	GO:0003924	GTPase activity
0.32	GO:0032550	purine ribonucleoside binding
0.32	GO:0032561	guanyl ribonucleotide binding
0.32	GO:0003677	DNA binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.33	GO:0031984	organelle subcompartment
0.33	GO:0012505	endomembrane system
0.33	GO:0005901	caveola
0.33	GO:0031090	organelle membrane
0.32	GO:0043231	intracellular membrane-bounded organelle
0.32	GO:0044444	cytoplasmic part
0.30	GO:0016021	integral component of membrane

0.68

GO:0016705

tr|T1EDP8|T1EDP8_HELRO
Uncharacterized protein
Search

0.55	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

0.67	GO:0071805	potassium ion transmembrane transport
0.63	GO:0043269	regulation of ion transport
0.62	GO:0034762	regulation of transmembrane transport
0.53	GO:0016057	regulation of membrane potential in photoreceptor cell
0.53	GO:0007637	proboscis extension reflex
0.53	GO:0071632	optomotor response
0.53	GO:0050802	circadian sleep/wake cycle, sleep
0.52	GO:0071484	cellular response to light intensity
0.52	GO:0045938	positive regulation of circadian sleep/wake cycle, sleep
0.51	GO:0050433	regulation of catecholamine secretion

0.71	GO:0005249	voltage-gated potassium channel activity
0.38	GO:0030552	cAMP binding
0.38	GO:0005248	voltage-gated sodium channel activity
0.37	GO:0005222	intracellular cAMP activated cation channel activity
0.35	GO:0004692	cGMP-dependent protein kinase activity
0.34	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.33	GO:0005515	protein binding
0.32	GO:0003677	DNA binding

0.38	GO:0044316	cone cell pedicle
0.38	GO:0005887	integral component of plasma membrane
0.37	GO:0043025	neuronal cell body
0.37	GO:0030425	dendrite
0.37	GO:0030424	axon
0.33	GO:0005634	nucleus

0.35

EC:2.7.11.12

GO:0004692

tr|T1EDP9|T1EDP9_HELRO
Uncharacterized protein
Search

RPL13

0.68	Ribosomal protein l13 (Fragment)

0.59	GO:0043043	peptide biosynthetic process
0.55	GO:0044267	cellular protein metabolic process
0.53	GO:0010467	gene expression
0.52	GO:0009059	macromolecule biosynthetic process
0.35	GO:0051726	regulation of cell cycle
0.33	GO:0006281	DNA repair

0.63	GO:0003735	structural constituent of ribosome
0.37	GO:0003723	RNA binding
0.34	GO:0003689	DNA clamp loader activity
0.32	GO:0046872	metal ion binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005840	ribosome
0.39	GO:0044445	cytosolic part
0.37	GO:0044446	intracellular organelle part
0.34	GO:0005783	endoplasmic reticulum
0.34	GO:0031974	membrane-enclosed lumen
0.34	GO:0005634	nucleus
0.33	GO:0005694	chromosome
0.32	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDQ0|T1EDQ0_HELRO
Uncharacterized protein
Search

RAB2A

0.78	Ras-related protein Rab-2

0.44	GO:0007030	Golgi organization
0.41	GO:0016192	vesicle-mediated transport
0.40	GO:0015031	protein transport
0.37	GO:0046907	intracellular transport
0.36	GO:0032482	Rab protein signal transduction
0.35	GO:0043687	post-translational protein modification
0.34	GO:0034613	cellular protein localization

0.66	GO:0003924	GTPase activity
0.64	GO:0032550	purine ribonucleoside binding
0.64	GO:0019001	guanyl nucleotide binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding

0.46	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
0.45	GO:0005794	Golgi apparatus
0.44	GO:0042470	melanosome
0.42	GO:0005789	endoplasmic reticulum membrane
0.37	GO:0005765	lysosomal membrane
0.37	GO:0070062	extracellular exosome
0.35	GO:0043025	neuronal cell body
0.35	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0005634	nucleus
0.34	GO:0005829	cytosol

tr|T1EDQ1|T1EDQ1_HELRO
Uncharacterized protein
Search

MED4

0.87	Mediator of RNA polymerase II transcription subunit 4

0.71	GO:0006357	regulation of transcription by RNA polymerase II
0.58	GO:0006351	transcription, DNA-templated
0.51	GO:0030521	androgen receptor signaling pathway
0.46	GO:0045893	positive regulation of transcription, DNA-templated
0.44	GO:0007406	negative regulation of neuroblast proliferation

0.79	GO:0001104	RNA polymerase II transcription cofactor activity
0.52	GO:0046966	thyroid hormone receptor binding
0.43	GO:0004872	receptor activity
0.42	GO:0003713	transcription coactivator activity
0.35	GO:0042809	vitamin D receptor binding

0.77	GO:0016592	mediator complex
0.47	GO:0070847	core mediator complex
0.30	GO:0016020	membrane

tr|T1EDQ2|T1EDQ2_HELRO
Uncharacterized protein
Search

MED31

0.71	Mediator of RNA polymerase II transcription subunit 31-B

0.69	GO:0006357	regulation of transcription by RNA polymerase II
0.57	GO:0006351	transcription, DNA-templated
0.53	GO:0048147	negative regulation of fibroblast proliferation
0.50	GO:0060173	limb development
0.36	GO:0016567	protein ubiquitination

0.77	GO:0001104	RNA polymerase II transcription cofactor activity
0.44	GO:0003713	transcription coactivator activity
0.36	GO:0061630	ubiquitin protein ligase activity
0.34	GO:0005515	protein binding

0.75	GO:0016592	mediator complex
0.46	GO:0070847	core mediator complex
0.36	GO:0000151	ubiquitin ligase complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDQ3|T1EDQ3_HELRO
Uncharacterized protein
Search

NIF3L1

0.97	NGG1 interacting factor 3 like 1

0.51	GO:0030182	neuron differentiation
0.49	GO:0045893	positive regulation of transcription, DNA-templated
0.49	GO:1903507	negative regulation of nucleic acid-templated transcription
0.34	GO:0016573	histone acetylation

0.50	GO:0042802	identical protein binding
0.49	GO:0008134	transcription factor binding
0.41	GO:0016787	hydrolase activity
0.34	GO:0004402	histone acetyltransferase activity

0.52	GO:0005634	nucleus
0.46	GO:0005739	mitochondrion
0.34	GO:0031248	protein acetyltransferase complex
0.33	GO:0043233	organelle lumen
0.32	GO:0043234	protein complex
0.32	GO:0044446	intracellular organelle part

0.41

GO:0016787

tr|T1EDQ4|T1EDQ4_HELRO
Uncharacterized protein
Search

0.46	GO:1903506	regulation of nucleic acid-templated transcription
0.46	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.46	GO:0010468	regulation of gene expression
0.45	GO:0097659	nucleic acid-templated transcription
0.43	GO:0010467	gene expression
0.42	GO:0034645	cellular macromolecule biosynthetic process
0.33	GO:0055085	transmembrane transport

0.51	GO:0003676	nucleic acid binding
0.47	GO:0003700	DNA binding transcription factor activity
0.45	GO:0046872	metal ion binding
0.35	GO:0005515	protein binding

0.49	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDQ5|T1EDQ5_HELRO
Uncharacterized protein
Search

0.45	GO:0000349	generation of catalytic spliceosome for first transesterification step
0.45	GO:0034247	snoRNA splicing
0.34	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.34	GO:0043484	regulation of RNA splicing
0.33	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.32	GO:0006400	tRNA modification
0.32	GO:0055114	oxidation-reduction process

0.67	GO:0004386	helicase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0003676	nucleic acid binding
0.44	GO:0008186	RNA-dependent ATPase activity
0.36	GO:0140098	catalytic activity, acting on RNA
0.34	GO:0042802	identical protein binding
0.33	GO:0008641	ubiquitin-like modifier activating enzyme activity
0.33	GO:0005549	odorant binding

0.45	GO:0071006	U2-type catalytic step 1 spliceosome
0.36	GO:0005730	nucleolus
0.34	GO:0005737	cytoplasm
0.34	GO:0071011	precatalytic spliceosome
0.33	GO:0071014	post-mRNA release spliceosomal complex
0.33	GO:0071013	catalytic step 2 spliceosome
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016491

tr|T1EDQ6|T1EDQ6_HELRO
Uncharacterized protein
Search

0.52	Putative guanine nucleotide exchange factor for rho and rac gtpase (Fragment)

0.78	GO:0035023	regulation of Rho protein signal transduction
0.66	GO:0065009	regulation of molecular function
0.48	GO:0035556	intracellular signal transduction
0.34	GO:0048332	mesoderm morphogenesis
0.34	GO:0048513	animal organ development
0.34	GO:0006426	glycyl-tRNA aminoacylation
0.34	GO:0033623	regulation of integrin activation
0.34	GO:0071800	podosome assembly
0.33	GO:0016322	neuron remodeling
0.33	GO:0022405	hair cycle process

0.78	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.34	GO:0004820	glycine-tRNA ligase activity
0.33	GO:0008092	cytoskeletal protein binding
0.33	GO:0048365	Rac GTPase binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.39	GO:0005622	intracellular
0.33	GO:0043228	non-membrane-bounded organelle
0.30	GO:0016020	membrane

0.34

EC:6.1.1.14

GO:0004820

tr|T1EDQ7|T1EDQ7_HELRO
Uncharacterized protein
Search

0.44	Transcription factor, putative

tr|T1EDQ8|T1EDQ8_HELRO
Uncharacterized protein
Search

ATG7

0.73	Ubiquitin modifier-activating enzyme ATG7

0.77	GO:0006914	autophagy
0.53	GO:0061726	mitochondrion disassembly
0.51	GO:0006497	protein lipidation
0.50	GO:0009267	cellular response to starvation
0.49	GO:0071455	cellular response to hyperoxia
0.47	GO:0018410	C-terminal protein amino acid modification
0.47	GO:0043562	cellular response to nitrogen levels
0.46	GO:0007033	vacuole organization
0.46	GO:0009896	positive regulation of catabolic process
0.45	GO:0043065	positive regulation of apoptotic process

0.76	GO:0008641	ubiquitin-like modifier activating enzyme activity
0.45	GO:0042802	identical protein binding
0.43	GO:0008134	transcription factor binding
0.42	GO:0046983	protein dimerization activity
0.37	GO:0016740	transferase activity
0.32	GO:0140096	catalytic activity, acting on a protein

0.49	GO:0005737	cytoplasm
0.38	GO:0031312	extrinsic component of organelle membrane
0.37	GO:0098805	whole membrane
0.36	GO:0120025	plasma membrane bounded cell projection
0.36	GO:0097458	neuron part
0.35	GO:0044463	cell projection part
0.35	GO:0044430	cytoskeletal part
0.30	GO:0031224	intrinsic component of membrane

0.37

GO:0016740

tr|T1EDQ9|T1EDQ9_HELRO
Uncharacterized protein
Search

0.83	GO:0071526	semaphorin-plexin signaling pathway
0.53	GO:0097374	sensory neuron axon guidance
0.50	GO:0008038	neuron recognition
0.49	GO:0071678	olfactory bulb axon guidance
0.49	GO:0008045	motor neuron axon guidance
0.46	GO:0050770	regulation of axonogenesis
0.44	GO:0043087	regulation of GTPase activity
0.43	GO:0031284	positive regulation of guanylate cyclase activity
0.42	GO:0050920	regulation of chemotaxis
0.42	GO:0051270	regulation of cellular component movement

0.84	GO:0017154	semaphorin receptor activity
0.43	GO:0010853	cyclase activator activity
0.43	GO:0071889	14-3-3 protein binding
0.43	GO:0030249	guanylate cyclase regulator activity
0.42	GO:0008201	heparin binding
0.40	GO:0005096	GTPase activator activity
0.35	GO:0032794	GTPase activating protein binding
0.32	GO:0001047	core promoter binding
0.32	GO:0003707	steroid hormone receptor activity
0.32	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding

0.45	GO:0030425	dendrite
0.36	GO:0002116	semaphorin receptor complex
0.36	GO:0005887	integral component of plasma membrane
0.34	GO:0005622	intracellular
0.32	GO:0043227	membrane-bounded organelle

tr|T1EDR0|T1EDR0_HELRO
Uncharacterized protein
Search

0.52	GO:0055114	oxidation-reduction process
0.33	GO:0035023	regulation of Rho protein signal transduction
0.33	GO:0071897	DNA biosynthetic process
0.33	GO:0006260	DNA replication
0.32	GO:0065009	regulation of molecular function
0.32	GO:0006621	protein retention in ER lumen
0.32	GO:0007601	visual perception
0.32	GO:0007186	G-protein coupled receptor signaling pathway
0.32	GO:0006468	protein phosphorylation
0.31	GO:0055085	transmembrane transport

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.67	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.33	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.33	GO:0003887	DNA-directed DNA polymerase activity
0.32	GO:0046923	ER retention sequence binding
0.32	GO:0004930	G-protein coupled receptor activity
0.32	GO:0003677	DNA binding
0.32	GO:0004672	protein kinase activity

0.34	GO:0005783	endoplasmic reticulum
0.33	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.33	GO:0031984	organelle subcompartment
0.33	GO:0031090	organelle membrane
0.30	GO:0031224	intrinsic component of membrane

0.68

GO:0016705

tr|T1EDR1|T1EDR1_HELRO
Uncharacterized protein
Search

0.20	Serine hydroxymethyltransferase

0.75	GO:0019264	glycine biosynthetic process from serine
0.72	GO:0035999	tetrahydrofolate interconversion
0.53	GO:0032259	methylation
0.42	GO:1904481	response to tetrahydrofolate
0.42	GO:0006565	L-serine catabolic process
0.40	GO:0051289	protein homotetramerization
0.40	GO:0071229	cellular response to acid chemical
0.40	GO:0071417	cellular response to organonitrogen compound
0.39	GO:0046655	folic acid metabolic process
0.39	GO:0071407	cellular response to organic cyclic compound

0.75	GO:0004372	glycine hydroxymethyltransferase activity
0.64	GO:0030170	pyridoxal phosphate binding
0.53	GO:0008168	methyltransferase activity
0.42	GO:0070905	serine binding
0.41	GO:0000900	translation repressor activity, nucleic acid binding
0.40	GO:0048027	mRNA 5'-UTR binding
0.39	GO:0042803	protein homodimerization activity
0.34	GO:0003682	chromatin binding
0.34	GO:0008732	L-allo-threonine aldolase activity
0.33	GO:0008266	poly(U) RNA binding

0.42	GO:0005739	mitochondrion
0.41	GO:0005829	cytosol
0.39	GO:0005634	nucleus
0.34	GO:0009295	nucleoid
0.34	GO:0031974	membrane-enclosed lumen
0.34	GO:0010319	stromule
0.34	GO:0015630	microtubule cytoskeleton
0.33	GO:0070062	extracellular exosome
0.33	GO:0048046	apoplast
0.33	GO:0009570	chloroplast stroma

0.75

EC:2.1.2.1

GO:0004372

tr|T1EDR2|T1EDR2_HELRO
Uncharacterized protein
Search

tr|T1EDR3|T1EDR3_HELRO
Uncharacterized protein
Search

0.10

Histone 1

0.79	GO:0006334	nucleosome assembly
0.33	GO:0031936	negative regulation of chromatin silencing
0.33	GO:0045910	negative regulation of DNA recombination
0.33	GO:0030261	chromosome condensation
0.33	GO:0009072	aromatic amino acid family metabolic process
0.32	GO:0055114	oxidation-reduction process

0.55	GO:0003677	DNA binding
0.34	GO:0003868	4-hydroxyphenylpyruvate dioxygenase activity
0.34	GO:0046982	protein heterodimerization activity
0.33	GO:0042301	phosphate ion binding
0.33	GO:0003682	chromatin binding

0.75	GO:0000786	nucleosome
0.61	GO:0005634	nucleus
0.32	GO:0031974	membrane-enclosed lumen
0.30	GO:0016020	membrane

0.34

EC:1.13.11.27

GO:0003868

tr|T1EDR4|T1EDR4_HELRO
Uncharacterized protein
Search

SLC35B4

0.81	UDP-xylose and UDP-N-acetylglucosamine transporter

0.61	GO:0015790	UDP-xylose transmembrane transport
0.59	GO:1990569	UDP-N-acetylglucosamine transmembrane transport
0.52	GO:0006111	regulation of gluconeogenesis
0.51	GO:0015783	GDP-fucose transmembrane transport
0.43	GO:0036066	protein O-linked fucosylation
0.42	GO:0015012	heparan sulfate proteoglycan biosynthetic process
0.38	GO:0008643	carbohydrate transport
0.35	GO:0015782	CMP-N-acetylneuraminate transmembrane transport
0.35	GO:0015787	UDP-glucuronic acid transmembrane transport
0.35	GO:1990570	GDP-mannose transmembrane transport

0.61	GO:0005464	UDP-xylose transmembrane transporter activity
0.60	GO:0005462	UDP-N-acetylglucosamine transmembrane transporter activity
0.51	GO:0005457	GDP-fucose transmembrane transporter activity
0.35	GO:0005456	CMP-N-acetylneuraminate transmembrane transporter activity
0.35	GO:0005461	UDP-glucuronic acid transmembrane transporter activity
0.35	GO:0005458	GDP-mannose transmembrane transporter activity
0.35	GO:0005460	UDP-glucose transmembrane transporter activity
0.33	GO:0070001	aspartic-type peptidase activity
0.33	GO:0004175	endopeptidase activity
0.33	GO:0005515	protein binding

0.49	GO:0005783	endoplasmic reticulum
0.48	GO:0005794	Golgi apparatus
0.44	GO:0031301	integral component of organelle membrane
0.43	GO:0098588	bounding membrane of organelle
0.43	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.42	GO:0031984	organelle subcompartment

tr|T1EDR5|T1EDR5_HELRO
Uncharacterized protein
Search

tr|T1EDR6|T1EDR6_HELRO
Uncharacterized protein
Search

OPLAH

0.50	5-oxoprolinase, ATP-hydrolysing

0.42	GO:0006749	glutathione metabolic process
0.37	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c
0.34	GO:0019184	nonribosomal peptide biosynthetic process
0.33	GO:0042398	cellular modified amino acid biosynthetic process
0.33	GO:0044272	sulfur compound biosynthetic process
0.33	GO:0006004	fucose metabolic process
0.33	GO:0051188	cofactor biosynthetic process

0.51	GO:0016787	hydrolase activity
0.34	GO:0032555	purine ribonucleotide binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0030554	adenyl nucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0016757	transferase activity, transferring glycosyl groups

0.40	GO:0005829	cytosol
0.38	GO:0005750	mitochondrial respiratory chain complex III

0.51

GO:0016787

tr|T1EDR7|T1EDR7_HELRO
Uncharacterized protein
Search

0.23	Histone deacetylase

0.79	GO:0070932	histone H3 deacetylation
0.56	GO:0006351	transcription, DNA-templated
0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.45	GO:0007616	long-term memory
0.43	GO:0010832	negative regulation of myotube differentiation
0.43	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
0.43	GO:0016573	histone acetylation
0.42	GO:0043393	regulation of protein binding

0.79	GO:0004407	histone deacetylase activity
0.76	GO:0034979	NAD-dependent protein deacetylase activity
0.51	GO:0046872	metal ion binding
0.43	GO:0005080	protein kinase C binding
0.42	GO:0070491	repressing transcription factor binding
0.42	GO:0042826	histone deacetylase binding
0.42	GO:0001085	RNA polymerase II transcription factor binding
0.42	GO:0001047	core promoter binding
0.35	GO:0001226	RNA polymerase II transcription corepressor binding
0.34	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding

0.78	GO:0000118	histone deacetylase complex
0.41	GO:0016607	nuclear speck
0.41	GO:0005737	cytoplasm
0.38	GO:0012505	endomembrane system
0.34	GO:0090571	RNA polymerase II transcription repressor complex
0.34	GO:0000790	nuclear chromatin
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:3.5.1.98

GO:0004407

tr|T1EDR8|T1EDR8_HELRO
Uncharacterized protein
Search

0.69	Dynamin GTPase

0.84	GO:0000266	mitochondrial fission
0.83	GO:0016559	peroxisome fission
0.45	GO:0030382	sperm mitochondrion organization
0.44	GO:0007370	ventral furrow formation
0.44	GO:0090141	positive regulation of mitochondrial fission
0.42	GO:0051646	mitochondrion localization
0.42	GO:0000281	mitotic cytokinesis
0.41	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission
0.37	GO:0061025	membrane fusion
0.37	GO:0016185	synaptic vesicle budding from presynaptic endocytic zone membrane

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0008017	microtubule binding
0.34	GO:0046983	protein dimerization activity
0.34	GO:0008061	chitin binding
0.34	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.34	GO:0000987	proximal promoter sequence-specific DNA binding

0.36	GO:0045202	synapse
0.36	GO:0031966	mitochondrial membrane
0.35	GO:0005875	microtubule associated complex
0.35	GO:0099501	exocytic vesicle membrane
0.34	GO:0005905	clathrin-coated pit
0.34	GO:0031968	organelle outer membrane
0.34	GO:0005777	peroxisome
0.34	GO:0097458	neuron part
0.34	GO:0030054	cell junction
0.34	GO:0005794	Golgi apparatus

tr|T1EDR9|T1EDR9_HELRO
Uncharacterized protein
Search

ISOC1

0.97	Isochorismatase domain-containing protein 1

0.30

GO:0008152

metabolic process

0.38	GO:0003676	nucleic acid binding
0.36	GO:0008908	isochorismatase activity
0.33	GO:0005515	protein binding
0.32	GO:0046872	metal ion binding

0.36	GO:0042579	microbody
0.35	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.36	EC:3.3.2.1	GO:0008908
0.36	KEGG:R03037	GO:0008908

tr|T1EDS0|T1EDS0_HELRO
Uncharacterized protein
Search

CRBN

0.95

Cereblon

0.52	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.49	GO:0016567	protein ubiquitination
0.39	GO:0032463	negative regulation of protein homooligomerization
0.39	GO:0090073	positive regulation of protein homodimerization activity
0.38	GO:0034766	negative regulation of ion transmembrane transport
0.35	GO:0035118	embryonic pectoral fin morphogenesis
0.35	GO:0071600	otic vesicle morphogenesis
0.35	GO:0060173	limb development

0.52	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.56	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex
0.48	GO:0005730	nucleolus
0.39	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EDS1|T1EDS1_HELRO
Uncharacterized protein
Search

0.85	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway
0.74	GO:0007411	axon guidance
0.69	GO:0009967	positive regulation of signal transduction

0.76	GO:0035591	signaling adaptor activity
0.76	GO:0019903	protein phosphatase binding

0.74	GO:0005925	focal adhesion
0.73	GO:0030424	axon
0.46	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EDS2|T1EDS2_HELRO
Cysteine protease
Search

ATG4A

0.59	Cysteine protease

0.76	GO:0006914	autophagy
0.65	GO:0015031	protein transport
0.60	GO:0006508	proteolysis
0.50	GO:0051697	protein delipidation
0.49	GO:0006501	C-terminal protein lipidation
0.48	GO:0061726	mitochondrion disassembly
0.46	GO:0007033	vacuole organization
0.44	GO:0090150	establishment of protein localization to membrane
0.43	GO:0070925	organelle assembly
0.43	GO:0046907	intracellular transport

0.73	GO:0004197	cysteine-type endopeptidase activity
0.33	GO:0005515	protein binding
0.33	GO:0004588	orotate phosphoribosyltransferase activity
0.32	GO:0019843	rRNA binding
0.32	GO:0003735	structural constituent of ribosome

0.48	GO:0005737	cytoplasm
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016020	membrane

0.73

GO:0004197

tr|T1EDS3|T1EDS3_HELRO
Uncharacterized protein
Search

0.44	GO:0016043	cellular component organization
0.43	GO:2001141	regulation of RNA biosynthetic process
0.42	GO:0043093	FtsZ-dependent cytokinesis
0.42	GO:0032506	cytokinetic process
0.41	GO:0006888	ER to Golgi vesicle-mediated transport
0.40	GO:0044085	cellular component biogenesis
0.40	GO:0006886	intracellular protein transport
0.40	GO:0018022	peptidyl-lysine methylation
0.38	GO:0007162	negative regulation of cell adhesion
0.38	GO:0006468	protein phosphorylation

0.49	GO:0003712	transcription cofactor activity
0.43	GO:0042834	peptidoglycan binding
0.41	GO:0042800	histone methyltransferase activity (H3-K4 specific)
0.40	GO:0046872	metal ion binding
0.40	GO:0050825	ice binding
0.40	GO:0005515	protein binding
0.38	GO:0044212	transcription regulatory region DNA binding
0.38	GO:0005545	1-phosphatidylinositol binding
0.38	GO:0016301	kinase activity
0.37	GO:0016773	phosphotransferase activity, alcohol group as acceptor

0.49	GO:0000124	SAGA complex
0.42	GO:0032153	cell division site
0.42	GO:0030135	coated vesicle
0.41	GO:0012505	endomembrane system
0.41	GO:0030660	Golgi-associated vesicle membrane
0.40	GO:0030659	cytoplasmic vesicle membrane
0.40	GO:0005887	integral component of plasma membrane
0.40	GO:0030117	membrane coat
0.40	GO:0035097	histone methyltransferase complex
0.40	GO:0031984	organelle subcompartment

0.37

GO:0016773

tr|T1EDS4|T1EDS4_HELRO
Oxysterol-binding protein
Search

OSBPL9

0.54	Oxysterol-binding protein (Fragment)

0.74

GO:0006869

lipid transport

0.42	GO:0005794	Golgi apparatus
0.41	GO:0005829	cytosol
0.30	GO:0044425	membrane part

tr|T1EDS5|T1EDS5_HELRO
Uncharacterized protein
Search

0.63	Salivary secreted ribonuclease

0.70	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.43	GO:0098586	cellular response to virus
0.37	GO:0032447	protein urmylation
0.36	GO:0034227	tRNA thio-modification
0.36	GO:0002098	tRNA wobble uridine modification
0.34	GO:0006508	proteolysis

0.70	GO:0004521	endoribonuclease activity
0.35	GO:0004222	metalloendopeptidase activity
0.35	GO:0000049	tRNA binding
0.34	GO:0008270	zinc ion binding
0.34	GO:0016779	nucleotidyltransferase activity

0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.35

GO:0004222

tr|T1EDS6|T1EDS6_HELRO
Uncharacterized protein
Search

0.42	Vitellogenin-1

0.58	GO:0006629	lipid metabolic process
0.43	GO:1901575	organic substance catabolic process
0.37	GO:0006968	cellular defense response
0.36	GO:0007586	digestion

0.70	GO:0052689	carboxylic ester hydrolase activity
0.56	GO:0016298	lipase activity

0.66	GO:0005576	extracellular region
0.34	GO:0000813	ESCRT I complex
0.30	GO:0031224	intrinsic component of membrane

0.70	EC:3.1.1 EC:3.1.1.1	GO:0052689
0.70	KEGG:R00630	GO:0052689

tr|T1EDS7|T1EDS7_HELRO
Uncharacterized protein
Search

0.49	Na+ dependent nucleoside transporter

0.79	GO:1901642	nucleoside transmembrane transport
0.38	GO:0015864	pyrimidine nucleoside transport
0.37	GO:1904823	purine nucleobase transmembrane transport
0.36	GO:0072531	pyrimidine-containing compound transmembrane transport
0.36	GO:0015855	pyrimidine nucleobase transport

0.78	GO:0005337	nucleoside transmembrane transporter activity
0.41	GO:0015370	solute:sodium symporter activity
0.37	GO:0005345	purine nucleobase transmembrane transporter activity
0.36	GO:0005350	pyrimidine nucleobase transmembrane transporter activity
0.33	GO:0046983	protein dimerization activity

0.42

GO:0005887

integral component of plasma membrane

tr|T1EDS8|T1EDS8_HELRO
Uncharacterized protein
Search

ELP2

0.73	Elongator acetyltransferase complex subunit 2

0.76	GO:0002098	tRNA wobble uridine modification
0.35	GO:0032447	protein urmylation
0.35	GO:0006627	protein processing involved in protein targeting to mitochondrion
0.35	GO:0046425	regulation of JAK-STAT cascade
0.34	GO:0006357	regulation of transcription by RNA polymerase II

0.41	GO:0032403	protein complex binding
0.39	GO:0008017	microtubule binding
0.38	GO:0001099	basal RNA polymerase II transcription machinery binding
0.38	GO:0043175	RNA polymerase core enzyme binding
0.34	GO:0019901	protein kinase binding
0.34	GO:0004222	metalloendopeptidase activity
0.32	GO:0046872	metal ion binding

0.81	GO:0033588	Elongator holoenzyme complex
0.39	GO:0000776	kinetochore
0.39	GO:0005813	centrosome
0.39	GO:0005875	microtubule associated complex
0.39	GO:0005938	cell cortex
0.38	GO:0005874	microtubule
0.38	GO:0008023	transcription elongation factor complex
0.38	GO:0000123	histone acetyltransferase complex
0.36	GO:0005829	cytosol
0.34	GO:0005759	mitochondrial matrix

0.34

GO:0004222

tr|T1EDS9|T1EDS9_HELRO
Uncharacterized protein
Search

tr|T1EDT0|T1EDT0_HELRO
Uncharacterized protein
Search

0.72	Furin, paired basic amino acid cleaving enzyme

0.61	GO:0006508	proteolysis
0.42	GO:0048856	anatomical structure development
0.42	GO:0032501	multicellular organismal process
0.41	GO:0008037	cell recognition
0.40	GO:0051604	protein maturation
0.40	GO:0007340	acrosome reaction
0.40	GO:1905910	negative regulation of dauer entry
0.39	GO:0030154	cell differentiation
0.39	GO:1901142	insulin metabolic process
0.39	GO:2000009	negative regulation of protein localization to cell surface

0.69	GO:0004252	serine-type endopeptidase activity
0.36	GO:0005102	receptor binding
0.35	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.35	GO:0048406	nerve growth factor binding
0.34	GO:0008201	heparin binding
0.33	GO:0004930	G-protein coupled receptor activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0008144	drug binding

0.40	GO:0002080	acrosomal membrane
0.38	GO:0043025	neuronal cell body
0.34	GO:0030424	axon
0.34	GO:0009986	cell surface
0.34	GO:0031012	extracellular matrix
0.34	GO:0005615	extracellular space
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.69

GO:0004252

tr|T1EDT1|T1EDT1_HELRO
Uncharacterized protein
Search

0.64	Regulator of G-protein signaling

0.76	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.62	GO:0035556	intracellular signal transduction
0.45	GO:0043547	positive regulation of GTPase activity
0.36	GO:0042407	cristae formation
0.34	GO:0009968	negative regulation of signal transduction

0.63	GO:0004871	signal transducer activity
0.46	GO:0031681	G-protein beta-subunit binding
0.45	GO:0005096	GTPase activator activity

0.80	GO:1905360	GTPase complex
0.79	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.65	GO:0098797	plasma membrane protein complex
0.40	GO:0005829	cytosol
0.36	GO:0061617	MICOS complex

tr|T1EDT2|T1EDT2_HELRO
Uncharacterized protein
Search

0.56	GO:0035556	intracellular signal transduction
0.49	GO:0014850	response to muscle activity
0.48	GO:0032963	collagen metabolic process
0.47	GO:0035264	multicellular organism growth
0.46	GO:0042127	regulation of cell proliferation
0.46	GO:0048871	multicellular organismal homeostasis
0.46	GO:0001822	kidney development
0.42	GO:0019725	cellular homeostasis
0.41	GO:0048523	negative regulation of cellular process
0.40	GO:0048286	lung alveolus development

0.48	GO:0046872	metal ion binding
0.45	GO:0019900	kinase binding
0.37	GO:0016301	kinase activity
0.36	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
0.34	GO:0031177	phosphopantetheine binding
0.34	GO:0005102	receptor binding
0.34	GO:0004721	phosphoprotein phosphatase activity
0.34	GO:0003723	RNA binding
0.32	GO:0016491	oxidoreductase activity

0.52	GO:0005925	focal adhesion
0.42	GO:0005622	intracellular
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.36

EC:3.1.3.67

GO:0016314

tr|T1EDT3|T1EDT3_HELRO
Uncharacterized protein
Search

0.77	Collapsin response mediator protein 1

0.80	GO:0007411	axon guidance
0.75	GO:0000226	microtubule cytoskeleton organization
0.71	GO:1904617	negative regulation of actin binding
0.71	GO:1904529	regulation of actin filament binding
0.67	GO:0010977	negative regulation of neuron projection development
0.44	GO:0051491	positive regulation of filopodium assembly
0.44	GO:0048678	response to axon injury
0.43	GO:0051017	actin filament bundle assembly
0.42	GO:0030334	regulation of cell migration

0.70	GO:0031005	filamin binding
0.65	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

0.66	GO:0030496	midbody
0.63	GO:0005813	centrosome
0.56	GO:0005829	cytosol

0.65

EC:3.5

GO:0016810

tr|T1EDT4|T1EDT4_HELRO
Uncharacterized protein
Search

0.56	probable G-protein coupled receptor 158

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.54	GO:0003371	establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
0.54	GO:0003379	establishment of cell polarity involved in gastrulation cell migration
0.54	GO:0048383	mesectoderm development
0.53	GO:0003384	apical constriction involved in gastrulation
0.53	GO:0043519	regulation of myosin II filament organization
0.52	GO:0002805	regulation of antimicrobial peptide biosynthetic process
0.51	GO:0060027	convergent extension involved in gastrulation
0.51	GO:0010470	regulation of gastrulation
0.32	GO:0055085	transmembrane transport

0.71	GO:0004930	G-protein coupled receptor activity
0.35	GO:0005509	calcium ion binding
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.37

GO:0005887

integral component of plasma membrane

tr|T1EDT5|T1EDT5_HELRO
Uncharacterized protein
Search

0.48	GO:1903506	regulation of nucleic acid-templated transcription
0.48	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.47	GO:0010468	regulation of gene expression
0.35	GO:2000191	regulation of fatty acid transport
0.35	GO:2001273	regulation of glucose import in response to insulin stimulus
0.35	GO:1902680	positive regulation of RNA biosynthetic process
0.35	GO:1902679	negative regulation of RNA biosynthetic process
0.35	GO:0006260	DNA replication
0.33	GO:0006351	transcription, DNA-templated
0.32	GO:1902600	hydrogen ion transmembrane transport

0.51	GO:0003676	nucleic acid binding
0.47	GO:0046872	metal ion binding
0.37	GO:0003700	DNA binding transcription factor activity
0.32	GO:0005515	protein binding
0.32	GO:0015002	heme-copper terminal oxidase activity
0.32	GO:0016675	oxidoreductase activity, acting on a heme group of donors
0.32	GO:0015078	hydrogen ion transmembrane transporter activity
0.32	GO:0009055	electron transfer activity

0.42	GO:0005634	nucleus
0.35	GO:0005811	lipid droplet
0.34	GO:0022626	cytosolic ribosome
0.34	GO:0012505	endomembrane system
0.33	GO:0044446	intracellular organelle part
0.33	GO:0031090	organelle membrane
0.33	GO:0031975	envelope
0.33	GO:0005694	chromosome
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0043234	protein complex

0.32

EC:1.9

GO:0016675

tr|T1EDT6|T1EDT6_HELRO
Uncharacterized protein
Search

EEF1G

0.59	Eukaryotic translation elongation factor 1 gamma

0.70	GO:0006414	translational elongation
0.43	GO:0009615	response to virus
0.41	GO:0006749	glutathione metabolic process
0.34	GO:0006378	mRNA polyadenylation
0.33	GO:0006351	transcription, DNA-templated

0.71	GO:0003746	translation elongation factor activity
0.44	GO:0045296	cadherin binding
0.43	GO:0004364	glutathione transferase activity
0.35	GO:0050265	RNA uridylyltransferase activity
0.35	GO:0003730	mRNA 3'-UTR binding
0.34	GO:0003899	DNA-directed 5'-3' RNA polymerase activity

0.41	GO:0005783	endoplasmic reticulum
0.40	GO:0005634	nucleus
0.36	GO:0070062	extracellular exosome
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.43

EC:2.5.1.18

GO:0004364

tr|T1EDT7|T1EDT7_HELRO
Uncharacterized protein
Search

tr|T1EDT8|T1EDT8_HELRO
Ubiquitinyl hydrolase 1
Search

USP5

0.58	Ubiquitinyl hydrolase 1

0.76	GO:0016579	protein deubiquitination
0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.51	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.45	GO:0090364	regulation of proteasome assembly
0.45	GO:0010995	free ubiquitin chain depolymerization
0.44	GO:0046329	negative regulation of JNK cascade
0.43	GO:0001751	compound eye photoreceptor cell differentiation
0.42	GO:0010498	proteasomal protein catabolic process
0.41	GO:0043066	negative regulation of apoptotic process
0.37	GO:0036506	maintenance of unfolded protein

0.78	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.63	GO:0008270	zinc ion binding
0.51	GO:0043130	ubiquitin binding
0.43	GO:1990380	Lys48-specific deubiquitinase activity
0.37	GO:1904454	ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
0.37	GO:1904288	BAT3 complex binding
0.36	GO:0070628	proteasome binding
0.36	GO:0019899	enzyme binding
0.35	GO:0051087	chaperone binding
0.35	GO:0004197	cysteine-type endopeptidase activity

0.33	GO:0005634	nucleus
0.32	GO:0005737	cytoplasm

0.35

GO:0004197

tr|T1EDT9|T1EDT9_HELRO
Uncharacterized protein
Search

ABCC1

0.72	ATP binding cassette subfamily C member 1

0.55	GO:0055085	transmembrane transport
0.53	GO:0099039	sphingolipid translocation
0.49	GO:0015711	organic anion transport
0.46	GO:0015748	organophosphate ester transport
0.44	GO:0071585	detoxification of cadmium ion
0.44	GO:0042908	xenobiotic transport
0.42	GO:0042939	tripeptide transport
0.41	GO:0015893	drug transport
0.41	GO:0072337	modified amino acid transport
0.40	GO:0072348	sulfur compound transport

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0046623	sphingolipid-translocating ATPase activity
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0004012	phospholipid-translocating ATPase activity
0.47	GO:0008514	organic anion transmembrane transporter activity
0.44	GO:0042910	xenobiotic transmembrane transporter activity
0.43	GO:0042937	tripeptide transporter activity
0.42	GO:0035673	oligopeptide transmembrane transporter activity

0.53	GO:0016323	basolateral plasma membrane
0.50	GO:0005887	integral component of plasma membrane
0.40	GO:0016324	apical plasma membrane
0.38	GO:0046581	intercellular canaliculus
0.36	GO:0009986	cell surface

0.48

EC:3.6.3.1

GO:0004012

tr|T1EDU0|T1EDU0_HELRO
Uncharacterized protein
Search

tr|T1EDU1|T1EDU1_HELRO
Uncharacterized protein
Search

0.88	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3

0.47	GO:0010501	RNA secondary structure unwinding
0.44	GO:0007059	chromosome segregation
0.43	GO:0006413	translational initiation
0.39	GO:0010468	regulation of gene expression
0.38	GO:0007420	brain development

0.67	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.45	GO:0008186	RNA-dependent ATPase activity
0.40	GO:0140098	catalytic activity, acting on RNA

0.46	GO:0036464	cytoplasmic ribonucleoprotein granule
0.44	GO:0005730	nucleolus

tr|T1EDU2|T1EDU2_HELRO
Uncharacterized protein
Search

0.69	Fimbrin/plastin

0.42	GO:0051639	actin filament network formation
0.41	GO:0051764	actin crosslink formation
0.40	GO:0051017	actin filament bundle assembly
0.38	GO:0016321	female meiosis chromosome segregation
0.35	GO:0001501	skeletal system development
0.35	GO:0048513	animal organ development
0.34	GO:0008045	motor neuron axon guidance
0.34	GO:1904888	cranial skeletal system development
0.34	GO:0001503	ossification
0.34	GO:0043009	chordate embryonic development

0.73	GO:0003779	actin binding
0.65	GO:0005509	calcium ion binding
0.56	GO:0032403	protein complex binding
0.34	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity
0.33	GO:0050660	flavin adenine dinucleotide binding
0.33	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.33	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
0.32	GO:0003677	DNA binding

0.41	GO:0032432	actin filament bundle
0.40	GO:0005884	actin filament
0.37	GO:0045179	apical cortex
0.37	GO:0070938	contractile ring
0.36	GO:0005829	cytosol
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.34	EC:2.4.2.19	GO:0004514
0.34	KEGG:R03348	GO:0004514

tr|T1EDU3|T1EDU3_HELRO
Uncharacterized protein
Search

0.67	Maternal protein pumilio

0.45	GO:0061013	regulation of mRNA catabolic process
0.45	GO:0016441	posttranscriptional gene silencing
0.45	GO:0007280	pole cell migration
0.44	GO:0008258	head involution
0.44	GO:0048149	behavioral response to ethanol
0.44	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
0.44	GO:0008582	regulation of synaptic growth at neuromuscular junction
0.44	GO:0007616	long-term memory
0.43	GO:1903313	positive regulation of mRNA metabolic process
0.43	GO:0048813	dendrite morphogenesis

0.59	GO:0003723	RNA binding
0.35	GO:0000900	translation repressor activity, nucleic acid binding
0.34	GO:0005509	calcium ion binding

0.45	GO:0061177	type Is terminal bouton
0.45	GO:0061176	type Ib terminal bouton
0.45	GO:0097482	muscle cell postsynaptic specialization
0.43	GO:0005635	nuclear envelope
0.39	GO:0010494	cytoplasmic stress granule
0.38	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0005829	cytosol
0.35	GO:0031090	organelle membrane
0.30	GO:0016021	integral component of membrane

tr|T1EDU4|T1EDU4_HELRO
Uncharacterized protein
Search

NACA

0.74	Nascent polypeptide-associated complex alpha polypeptide

0.45	GO:0030239	myofibril assembly
0.40	GO:1901227	negative regulation of transcription from RNA polymerase II promoter involved in heart development
0.39	GO:0048633	positive regulation of skeletal muscle tissue growth
0.39	GO:1901228	positive regulation of transcription from RNA polymerase II promoter involved in heart development
0.38	GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis
0.38	GO:0048742	regulation of skeletal muscle fiber development
0.38	GO:0051451	myoblast migration
0.38	GO:0010664	negative regulation of striated muscle cell apoptotic process
0.38	GO:0043403	skeletal muscle tissue regeneration
0.38	GO:0061384	heart trabecula morphogenesis

0.37	GO:0017025	TBP-class protein binding
0.37	GO:0003713	transcription coactivator activity
0.35	GO:0051015	actin filament binding
0.34	GO:0003777	microtubule motor activity
0.34	GO:0008017	microtubule binding
0.34	GO:0003677	DNA binding
0.33	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.80	GO:0005854	nascent polypeptide-associated complex
0.40	GO:0005634	nucleus
0.35	GO:0070062	extracellular exosome
0.34	GO:0016459	myosin complex

tr|T1EDU5|T1EDU5_HELRO
Uncharacterized protein
Search

SNRPB2

0.60	Small nuclear ribonucleoprotein polypeptide A

0.41	GO:0000398	mRNA splicing, via spliceosome
0.36	GO:0050684	regulation of mRNA processing
0.35	GO:0070868	heterochromatin organization involved in chromatin silencing
0.35	GO:0043484	regulation of RNA splicing
0.35	GO:0048477	oogenesis

0.59	GO:0003723	RNA binding
0.44	GO:0042802	identical protein binding
0.36	GO:1990446	U1 snRNP binding

0.59	GO:0019013	viral nucleocapsid
0.54	GO:0030529	intracellular ribonucleoprotein complex
0.49	GO:0120114	Sm-like protein family complex
0.44	GO:0044428	nuclear part
0.43	GO:0031974	membrane-enclosed lumen
0.35	GO:1902494	catalytic complex
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0043234	protein complex
0.30	GO:0016020	membrane

tr|T1EDU6|T1EDU6_HELRO
Uncharacterized protein
Search

0.41	GO:0003261	cardiac muscle progenitor cell migration to the midline involved in heart field formation
0.41	GO:0035264	multicellular organism growth
0.40	GO:1903506	regulation of nucleic acid-templated transcription
0.40	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.40	GO:0008078	mesodermal cell migration
0.40	GO:0010468	regulation of gene expression
0.39	GO:0042074	cell migration involved in gastrulation
0.39	GO:0048523	negative regulation of cellular process
0.38	GO:0006366	transcription by RNA polymerase II
0.38	GO:1902680	positive regulation of RNA biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.40	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.40	GO:0046872	metal ion binding
0.40	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.38	GO:0042803	protein homodimerization activity
0.32	GO:0016491	oxidoreductase activity

0.40	GO:0005634	nucleus
0.33	GO:0015629	actin cytoskeleton

0.32

GO:0016491

tr|T1EDU7|T1EDU7_HELRO
Uncharacterized protein
Search

tr|T1EDU8|T1EDU8_HELRO
Bestrophin homolog
Search

0.66	Bestrophin

0.75	GO:1902476	chloride transmembrane transport
0.49	GO:0007601	visual perception
0.45	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay
0.45	GO:0070481	nuclear-transcribed mRNA catabolic process, non-stop decay
0.44	GO:0071025	RNA surveillance
0.43	GO:0009992	cellular water homeostasis
0.36	GO:0051899	membrane depolarization
0.35	GO:0007608	sensory perception of smell

0.76	GO:0005254	chloride channel activity
0.43	GO:0005225	volume-sensitive anion channel activity
0.39	GO:0022839	ion gated channel activity
0.39	GO:0008381	mechanosensitive ion channel activity

0.78	GO:0034707	chloride channel complex
0.54	GO:0005886	plasma membrane
0.35	GO:0005929	cilium

tr|T1EDU9|T1EDU9_HELRO
Uncharacterized protein
Search

tr|T1EDV0|T1EDV0_HELRO
Uncharacterized protein
Search

0.75	gamma-glutamyltranspeptidase 1

0.79	GO:0006751	glutathione catabolic process
0.61	GO:0006508	proteolysis
0.39	GO:0050727	regulation of inflammatory response
0.38	GO:0007283	spermatogenesis
0.38	GO:0006750	glutathione biosynthetic process
0.38	GO:0019344	cysteine biosynthetic process
0.37	GO:0002682	regulation of immune system process
0.36	GO:0006805	xenobiotic metabolic process
0.33	GO:0035725	sodium ion transmembrane transport

0.80	GO:0036374	glutathione hydrolase activity
0.45	GO:0103068	leukotriene C4 gamma-glutamyl transferase activity
0.45	GO:0102953	hypoglycin A gamma-glutamyl transpeptidase activity
0.34	GO:0005272	sodium channel activity

0.37	GO:0031982	vesicle
0.36	GO:0000324	fungal-type vacuole
0.30	GO:0016020	membrane

0.80	EC:3.4.19.13	GO:0036374
0.80	KEGG:R00494	GO:0036374

tr|T1EDV1|T1EDV1_HELRO
Uncharacterized protein
Search

MED12L

0.77	Mediator of RNA polymerase II transcription subunit 12

0.68	GO:0006357	regulation of transcription by RNA polymerase II
0.53	GO:0090245	axis elongation involved in somitogenesis
0.52	GO:0048702	embryonic neurocranium morphogenesis
0.52	GO:0006366	transcription by RNA polymerase II
0.52	GO:1990403	embryonic brain development
0.51	GO:0030521	androgen receptor signaling pathway
0.51	GO:0036342	post-anal tail morphogenesis
0.51	GO:0014003	oligodendrocyte development
0.51	GO:0045893	positive regulation of transcription, DNA-templated
0.51	GO:0014044	Schwann cell development

0.79	GO:0008013	beta-catenin binding
0.76	GO:0001104	RNA polymerase II transcription cofactor activity
0.56	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.54	GO:0003713	transcription coactivator activity
0.52	GO:0046966	thyroid hormone receptor binding
0.51	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.50	GO:0008022	protein C-terminus binding
0.47	GO:0019904	protein domain specific binding
0.47	GO:0003682	chromatin binding
0.43	GO:0004872	receptor activity

0.77	GO:0016592	mediator complex
0.38	GO:0000151	ubiquitin ligase complex
0.30	GO:0016020	membrane

tr|T1EDV2|T1EDV2_HELRO
Uncharacterized protein
Search

0.38	Threonine dehydratase biosynthetic

0.58	GO:0006520	cellular amino acid metabolic process
0.39	GO:0046395	carboxylic acid catabolic process
0.39	GO:1901565	organonitrogen compound catabolic process
0.38	GO:0042866	pyruvate biosynthetic process
0.36	GO:0019319	hexose biosynthetic process
0.35	GO:0006006	glucose metabolic process
0.34	GO:0044272	sulfur compound biosynthetic process
0.33	GO:0030447	filamentous growth
0.33	GO:1901566	organonitrogen compound biosynthetic process
0.33	GO:0044267	cellular protein metabolic process

0.64	GO:0030170	pyridoxal phosphate binding
0.46	GO:0016841	ammonia-lyase activity
0.41	GO:0042802	identical protein binding
0.36	GO:0046983	protein dimerization activity
0.35	GO:0004124	cysteine synthase activity
0.34	GO:0003723	RNA binding
0.34	GO:0004795	threonine synthase activity
0.33	GO:0004825	methionine-tRNA ligase activity
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.40	GO:0042645	mitochondrial nucleoid
0.36	GO:0005829	cytosol

0.46

EC:4.3.1

GO:0016841

tr|T1EDV3|T1EDV3_HELRO
Uncharacterized protein
Search

0.60	GO:0006508	proteolysis
0.48	GO:0007229	integrin-mediated signaling pathway
0.45	GO:0060468	prevention of polyspermy
0.35	GO:0007283	spermatogenesis
0.35	GO:0051259	protein oligomerization
0.34	GO:0030154	cell differentiation
0.34	GO:0007275	multicellular organism development
0.33	GO:0009116	nucleoside metabolic process

0.70	GO:0004222	metalloendopeptidase activity
0.53	GO:0046872	metal ion binding
0.36	GO:0005178	integrin binding
0.35	GO:0042802	identical protein binding

0.37	GO:1990913	sperm head plasma membrane
0.35	GO:0009897	external side of plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.70

GO:0004222

tr|T1EDV4|T1EDV4_HELRO
Protein-S-isoprenylcysteine O-methyltransferase
Search

ICMT

0.62	Protein-S-isoprenylcysteine O-methyltransferase

0.82	GO:0006481	C-terminal protein methylation
0.37	GO:0007186	G-protein coupled receptor signaling pathway
0.36	GO:0035264	multicellular organism growth
0.36	GO:0001889	liver development
0.35	GO:0001701	in utero embryonic development
0.35	GO:0008284	positive regulation of cell proliferation
0.35	GO:0008104	protein localization
0.35	GO:0046578	regulation of Ras protein signal transduction
0.34	GO:0046499	S-adenosylmethioninamine metabolic process
0.34	GO:0071432	peptide mating pheromone maturation involved in conjugation with cellular fusion

0.83	GO:0004671	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
0.37	GO:0004930	G-protein coupled receptor activity
0.36	GO:0008140	cAMP response element binding protein binding
0.33	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.32	GO:0003735	structural constituent of ribosome
0.32	GO:0005524	ATP binding

0.71	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0005637	nuclear inner membrane
0.32	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

0.83	EC:2.1.1.100	GO:0004671
0.83	KEGG:R04496	GO:0004671

tr|T1EDV5|T1EDV5_HELRO
Uncharacterized protein
Search

ERCC2

0.89	General transcription and DNA repair factor IIH helicase subunit XPD

0.73	GO:0006289	nucleotide-excision repair
0.70	GO:0032508	DNA duplex unwinding
0.49	GO:0009411	response to UV
0.49	GO:1901990	regulation of mitotic cell cycle phase transition
0.48	GO:0032289	central nervous system myelin formation
0.47	GO:0035315	hair cell differentiation
0.47	GO:0048820	hair follicle maturation
0.47	GO:0040016	embryonic cleavage
0.47	GO:0043249	erythrocyte maturation
0.46	GO:0007348	regulation of syncytial blastoderm mitotic cell cycle

0.72	GO:0004003	ATP-dependent DNA helicase activity
0.55	GO:0030554	adenyl nucleotide binding
0.55	GO:0003677	DNA binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0043139	5'-3' DNA helicase activity
0.47	GO:0047485	protein N-terminus binding
0.46	GO:0008022	protein C-terminus binding
0.46	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity

0.61	GO:0005634	nucleus
0.50	GO:1902554	serine/threonine protein kinase complex
0.48	GO:0071817	MMXD complex
0.48	GO:0000428	DNA-directed RNA polymerase complex
0.48	GO:0005667	transcription factor complex
0.47	GO:0150005	enzyme activator complex
0.45	GO:0005703	polytene chromosome puff
0.45	GO:0005705	polytene chromosome interband
0.45	GO:0070013	intracellular organelle lumen
0.42	GO:0005829	cytosol

0.46

EC:2.7.11.23

GO:0008353

tr|T1EDV6|T1EDV6_HELRO
Uncharacterized protein
Search

ERGIC3

0.92	ERGIC and golgi 3

0.30

GO:0044425

membrane part

tr|T1EDV7|T1EDV7_HELRO
Uncharacterized protein
Search

ARHGAP8

0.67	Rho GTPase-activating protein 1

0.60	GO:0007165	signal transduction
0.43	GO:0043087	regulation of GTPase activity
0.38	GO:0051345	positive regulation of hydrolase activity
0.35	GO:1902531	regulation of intracellular signal transduction
0.35	GO:2001136	negative regulation of endocytic recycling
0.35	GO:0098706	ferric iron import across plasma membrane
0.35	GO:0048522	positive regulation of cellular process
0.34	GO:0033572	transferrin transport
0.34	GO:0032439	endosome localization
0.34	GO:0040017	positive regulation of locomotion

0.38	GO:0030695	GTPase regulator activity
0.37	GO:0008047	enzyme activator activity
0.34	GO:0045296	cadherin binding
0.34	GO:0017137	Rab GTPase binding
0.32	GO:0008270	zinc ion binding

0.35	GO:0005737	cytoplasm
0.33	GO:0097708	intracellular vesicle
0.33	GO:0098805	whole membrane
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0012505	endomembrane system
0.32	GO:0044446	intracellular organelle part
0.32	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

tr|T1EDV8|T1EDV8_HELRO
Phosphotransferase
Search

0.55	Phosphotransferase

0.82	GO:0001678	cellular glucose homeostasis
0.74	GO:0046835	carbohydrate phosphorylation
0.71	GO:0006757	ATP generation from ADP
0.69	GO:0006090	pyruvate metabolic process
0.68	GO:0016052	carbohydrate catabolic process
0.67	GO:0019362	pyridine nucleotide metabolic process
0.46	GO:0060361	flight
0.42	GO:0051156	glucose 6-phosphate metabolic process
0.38	GO:0006013	mannose metabolic process
0.38	GO:0006113	fermentation

0.83	GO:0005536	glucose binding
0.79	GO:0004396	hexokinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0042834	peptidoglycan binding
0.33	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.33	GO:0001882	nucleoside binding
0.32	GO:0003677	DNA binding

0.40	GO:0005829	cytosol
0.36	GO:0020015	glycosome
0.35	GO:0005739	mitochondrion
0.34	GO:0097228	sperm principal piece
0.34	GO:0045121	membrane raft
0.32	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.79

EC:2.7.1.1

GO:0004396

tr|T1EDV9|T1EDV9_HELRO
Uncharacterized protein
Search

VPS41

0.58	Vacuolar protein sorting-associated protein 41

0.69	GO:0006886	intracellular protein transport
0.68	GO:0016192	vesicle-mediated transport
0.47	GO:0035542	regulation of SNARE complex assembly
0.46	GO:0042144	vacuole fusion, non-autophagic
0.46	GO:0072666	establishment of protein localization to vacuole
0.45	GO:0007034	vacuolar transport
0.38	GO:0090174	organelle membrane fusion
0.38	GO:0016050	vesicle organization
0.37	GO:0016197	endosomal transport
0.37	GO:0016311	dephosphorylation

0.43	GO:0051020	GTPase binding
0.39	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity
0.37	GO:0008017	microtubule binding
0.37	GO:0042802	identical protein binding
0.35	GO:0043621	protein self-association
0.34	GO:0008378	galactosyltransferase activity
0.32	GO:0046872	metal ion binding

0.48	GO:0030897	HOPS complex
0.48	GO:0033263	CORVET complex
0.46	GO:0005770	late endosome
0.40	GO:0005765	lysosomal membrane
0.38	GO:0071439	clathrin complex
0.38	GO:0030123	AP-3 adaptor complex
0.38	GO:0005769	early endosome
0.38	GO:0030136	clathrin-coated vesicle
0.37	GO:0010008	endosome membrane
0.36	GO:0015630	microtubule cytoskeleton

0.39

EC:3.1.3.11

GO:0042132

tr|T1EDW0|T1EDW0_HELRO
Uncharacterized protein
Search

tr|T1EDW1|T1EDW1_HELRO
Uncharacterized protein
Search

0.38

GO:0006508

proteolysis

0.80	GO:0032947	protein complex scaffold activity
0.40	GO:0017171	serine hydrolase activity
0.39	GO:0070011	peptidase activity, acting on L-amino acid peptides
0.32	GO:0046872	metal ion binding

0.39	GO:0012505	endomembrane system
0.37	GO:0042597	periplasmic space
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDW2|T1EDW2_HELRO
Uncharacterized protein
Search

STARD7

0.82	StAR-related lipid transfer protein 7, mitochondrial

0.53	GO:1903955	positive regulation of protein targeting to mitochondrion
0.35	GO:0006656	phosphatidylcholine biosynthetic process

0.72

GO:0008289

lipid binding

0.34	GO:0005741	mitochondrial outer membrane
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDW3|T1EDW3_HELRO
Uncharacterized protein
Search

EED

0.88	Polycomb protein eed-A

0.77	GO:0016571	histone methylation
0.39	GO:2000011	regulation of adaxial/abaxial pattern formation
0.39	GO:0061087	positive regulation of histone H3-K27 methylation
0.38	GO:0006349	regulation of gene expression by genetic imprinting
0.38	GO:1990823	response to leukemia inhibitory factor
0.37	GO:0071345	cellular response to cytokine stimulus
0.37	GO:0018022	peptidyl-lysine methylation
0.37	GO:0000122	negative regulation of transcription by RNA polymerase II
0.36	GO:0070317	negative regulation of G0 to G1 transition
0.36	GO:0006351	transcription, DNA-templated

0.39	GO:0046976	histone methyltransferase activity (H3-K27 specific)
0.37	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.37	GO:0003682	chromatin binding
0.36	GO:0042802	identical protein binding

0.83	GO:0035098	ESC/E(Z) complex
0.39	GO:0001739	sex chromatin
0.38	GO:0045120	pronucleus
0.36	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDW4|T1EDW4_HELRO
Uncharacterized protein
Search

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.36	GO:0002062	chondrocyte differentiation
0.36	GO:0001503	ossification
0.35	GO:0030097	hemopoiesis
0.35	GO:0030182	neuron differentiation
0.35	GO:0045595	regulation of cell differentiation
0.34	GO:0015914	phospholipid transport
0.34	GO:0003094	glomerular filtration

0.61	GO:0003700	DNA binding transcription factor activity
0.54	GO:0003677	DNA binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005548	phospholipid transporter activity
0.34	GO:0046872	metal ion binding

0.61	GO:0005634	nucleus
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EDW5|T1EDW5_HELRO
Uncharacterized protein
Search

PCNX3

0.45	Pecanex protein 1

0.34	GO:0051056	regulation of small GTPase mediated signal transduction
0.34	GO:0043547	positive regulation of GTPase activity

0.34

GO:0005096

GTPase activator activity

0.30

GO:0044425

membrane part

tr|T1EDW6|T1EDW6_HELRO
Uncharacterized protein
Search

0.82	Selenoprotein O

0.41	GO:0035329	hippo signaling
0.41	GO:0000165	MAPK cascade
0.39	GO:0000278	mitotic cell cycle

0.42	GO:0004674	protein serine/threonine kinase activity
0.41	GO:0005057	signal transducer activity, downstream of receptor
0.37	GO:0032559	adenyl ribonucleotide binding
0.37	GO:0008144	drug binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding

0.58	GO:0005739	mitochondrion
0.38	GO:0009570	chloroplast stroma
0.30	GO:0016020	membrane

0.42

GO:0004674

tr|T1EDW7|T1EDW7_HELRO
Uncharacterized protein
Search

DUSP19

0.47	Dual specificity protein phosphatase

0.79	GO:0000188	inactivation of MAPK activity
0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.51	GO:0043508	negative regulation of JUN kinase activity
0.50	GO:1903753	negative regulation of p38MAPK cascade
0.50	GO:0045591	positive regulation of regulatory T cell differentiation
0.50	GO:1905042	negative regulation of epithelium regeneration
0.49	GO:0035970	peptidyl-threonine dephosphorylation
0.49	GO:0060266	negative regulation of respiratory burst involved in inflammatory response
0.48	GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
0.48	GO:0090335	regulation of brown fat cell differentiation

0.80	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
0.74	GO:0004725	protein tyrosine phosphatase activity
0.51	GO:0008330	protein tyrosine/threonine phosphatase activity
0.51	GO:0048273	mitogen-activated protein kinase p38 binding
0.50	GO:0008432	JUN kinase binding
0.34	GO:0016301	kinase activity
0.32	GO:0004222	metalloendopeptidase activity

0.46	GO:0016607	nuclear speck
0.44	GO:0005794	Golgi apparatus
0.43	GO:0005829	cytosol
0.36	GO:0031965	nuclear membrane
0.32	GO:0010494	cytoplasmic stress granule
0.32	GO:0030687	preribosome, large subunit precursor
0.30	GO:0016021	integral component of membrane

0.80

EC:3.1.3

GO:0017017

tr|T1EDW8|T1EDW8_HELRO
Uncharacterized protein
Search

LMBRD2

0.95	LMBR1 domain-containing protein 2-B

0.36

GO:0060271

cilium assembly

0.37	GO:0034464	BBSome
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDW9|T1EDW9_HELRO
Uncharacterized protein
Search

0.39	Zyg-11 related cell cycle regulator

0.74	GO:0051438	regulation of ubiquitin-protein transferase activity
0.66	GO:0016567	protein ubiquitination
0.48	GO:0006468	protein phosphorylation

0.67	GO:0004842	ubiquitin-protein transferase activity
0.51	GO:0004674	protein serine/threonine kinase activity

0.80	GO:0031462	Cul2-RING ubiquitin ligase complex
0.30	GO:0031224	intrinsic component of membrane

0.51	EC:2.7.11	GO:0004674
0.67	KEGG:R03876	GO:0004842

tr|T1EDX0|T1EDX0_HELRO
Uncharacterized protein
Search

0.92	Putative syntrophins type beta

0.76	GO:0050808	synapse organization
0.51	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation
0.50	GO:0086005	ventricular cardiac muscle cell action potential
0.49	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
0.48	GO:1902305	regulation of sodium ion transmembrane transport
0.48	GO:0002027	regulation of heart rate
0.42	GO:0065009	regulation of molecular function
0.38	GO:0003116	regulation of vasoconstriction by norepinephrine
0.33	GO:0006400	tRNA modification
0.33	GO:0035556	intracellular signal transduction

0.62	GO:0005198	structural molecule activity
0.50	GO:0050998	nitric-oxide synthase binding
0.49	GO:0017080	sodium channel regulator activity
0.48	GO:0051117	ATPase binding
0.48	GO:0044325	ion channel binding
0.37	GO:0005516	calmodulin binding
0.37	GO:0030165	PDZ domain binding
0.37	GO:0003779	actin binding
0.33	GO:0051539	4 iron, 4 sulfur cluster binding
0.33	GO:0004252	serine-type endopeptidase activity

0.78	GO:0016010	dystrophin-associated glycoprotein complex
0.40	GO:0042383	sarcolemma
0.37	GO:0031594	neuromuscular junction
0.37	GO:0030054	cell junction
0.36	GO:0005856	cytoskeleton
0.35	GO:0045211	postsynaptic membrane
0.34	GO:0016328	lateral plasma membrane
0.33	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.33

GO:0004252

tr|T1EDX1|T1EDX1_HELRO
Uncharacterized protein
Search

0.71	Transmembrane protein 144

0.72

GO:0034219

carbohydrate transmembrane transport

0.71

GO:0015144

carbohydrate transmembrane transporter activity

0.30

GO:0044425

membrane part

tr|T1EDX2|T1EDX2_HELRO
Uncharacterized protein
Search

0.51	GO:0000956	nuclear-transcribed mRNA catabolic process
0.50	GO:0008334	histone mRNA metabolic process
0.50	GO:1904872	regulation of telomerase RNA localization to Cajal body
0.50	GO:0032211	negative regulation of telomere maintenance via telomerase
0.45	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
0.43	GO:0010603	regulation of cytoplasmic mRNA processing body assembly
0.42	GO:0035195	gene silencing by miRNA
0.34	GO:0043488	regulation of mRNA stability

0.72	GO:0030145	manganese ion binding
0.59	GO:0003723	RNA binding
0.56	GO:0050072	m7G(5')pppN diphosphatase activity
0.47	GO:0004534	5'-3' exoribonuclease activity
0.33	GO:0005515	protein binding

0.52	GO:0000932	P-body
0.48	GO:0016442	RISC complex
0.45	GO:0030054	cell junction
0.43	GO:0005654	nucleoplasm
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.56

EC:3.6.1.30

GO:0050072

tr|T1EDX3|T1EDX3_HELRO
Elongation of very long chain fatty acids protein
Search

0.48	Elongation of very long chain fatty acids protein 4

0.74	GO:0019367	fatty acid elongation, saturated fatty acid
0.73	GO:0042761	very long-chain fatty acid biosynthetic process
0.69	GO:0034626	fatty acid elongation, polyunsaturated fatty acid
0.65	GO:0006636	unsaturated fatty acid biosynthetic process
0.61	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
0.53	GO:0034625	fatty acid elongation, monounsaturated fatty acid
0.47	GO:0030148	sphingolipid biosynthetic process
0.39	GO:0042759	long-chain fatty acid biosynthetic process
0.34	GO:0036109	alpha-linolenic acid metabolic process
0.34	GO:0043651	linoleic acid metabolic process

0.82	GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity
0.82	GO:0102338	3-oxo-lignoceronyl-CoA synthase activity
0.82	GO:0102336	3-oxo-arachidoyl-CoA synthase activity
0.82	GO:0102337	3-oxo-cerotoyl-CoA synthase activity
0.74	GO:0009922	fatty acid elongase activity
0.34	GO:0008020	G-protein coupled photoreceptor activity
0.33	GO:0005515	protein binding

0.61	GO:0005783	endoplasmic reticulum
0.59	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.56	GO:0031984	organelle subcompartment
0.42	GO:0030425	dendrite
0.33	GO:0005887	integral component of plasma membrane

0.82

EC:2.3.1.199

GO:0102338

tr|T1EDX4|T1EDX4_HELRO
Uncharacterized protein
Search

0.42	GO:0072001	renal system development
0.41	GO:0030198	extracellular matrix organization
0.41	GO:0048513	animal organ development
0.40	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
0.38	GO:0060562	epithelial tube morphogenesis
0.38	GO:0048619	embryonic hindgut morphogenesis
0.38	GO:0052548	regulation of endopeptidase activity
0.38	GO:0071230	cellular response to amino acid stimulus
0.37	GO:0014706	striated muscle tissue development
0.37	GO:0072577	endothelial cell apoptotic process

0.71	GO:0005201	extracellular matrix structural constituent
0.40	GO:0005509	calcium ion binding
0.38	GO:0030246	carbohydrate binding
0.37	GO:0004867	serine-type endopeptidase inhibitor activity
0.36	GO:0005178	integrin binding
0.36	GO:0048407	platelet-derived growth factor binding
0.36	GO:0042302	structural constituent of cuticle
0.35	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.35	GO:0005044	scavenger receptor activity

0.65	GO:0005581	collagen trimer
0.59	GO:0005604	basement membrane
0.44	GO:0098645	collagen network
0.38	GO:0005783	endoplasmic reticulum
0.37	GO:0005794	Golgi apparatus
0.35	GO:0019867	outer membrane
0.34	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane

0.35

GO:0004553

tr|T1EDX5|T1EDX5_HELRO
Uncharacterized protein
Search

SCCPDH

0.48	Saccharopine dehydrogenase oxidoreductase

0.52	GO:0055114	oxidation-reduction process
0.35	GO:0002576	platelet degranulation
0.33	GO:0042254	ribosome biogenesis

0.54

GO:0016491

oxidoreductase activity

0.50	GO:0030496	midbody
0.50	GO:0005811	lipid droplet
0.42	GO:0005739	mitochondrion
0.38	GO:0009941	chloroplast envelope
0.38	GO:0005774	vacuolar membrane
0.35	GO:0031093	platelet alpha granule lumen
0.34	GO:0005886	plasma membrane
0.33	GO:0005634	nucleus
0.33	GO:0005576	extracellular region
0.32	GO:0030529	intracellular ribonucleoprotein complex

0.54

GO:0016491

tr|T1EDX6|T1EDX6_HELRO
Uncharacterized protein
Search

CTNNAL1

0.86	Alpha-catulin (inferred by orthology to a human protein)

0.85	GO:0007266	Rho protein signal transduction
0.72	GO:0007155	cell adhesion
0.36	GO:0040012	regulation of locomotion

0.78	GO:0051015	actin filament binding
0.72	GO:0045296	cadherin binding

0.46	GO:0005829	cytosol
0.37	GO:0055120	striated muscle dense body
0.35	GO:0005856	cytoskeleton
0.34	GO:0071944	cell periphery
0.34	GO:0099568	cytoplasmic region
0.30	GO:0044425	membrane part

tr|T1EDX7|T1EDX7_HELRO
Uncharacterized protein
Search

POMGNT2

0.40	Glycosyltransferase

0.50	GO:0035269	protein O-linked mannosylation
0.49	GO:0001764	neuron migration
0.34	GO:0048747	muscle fiber development
0.34	GO:0060041	retina development in camera-type eye
0.33	GO:0007420	brain development

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.32	GO:0005515	protein binding

0.45	GO:0005783	endoplasmic reticulum
0.39	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.38	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.65

GO:0016757

tr|T1EDX8|T1EDX8_HELRO
Uncharacterized protein
Search

0.66	GO:0043547	positive regulation of GTPase activity
0.61	GO:0007165	signal transduction
0.39	GO:0006468	protein phosphorylation
0.33	GO:0099120	socially cooperative development
0.33	GO:0035023	regulation of Rho protein signal transduction
0.32	GO:0030435	sporulation resulting in formation of a cellular spore
0.32	GO:0018212	peptidyl-tyrosine modification

0.67	GO:0005096	GTPase activator activity
0.54	GO:0005543	phospholipid binding
0.39	GO:0004672	protein kinase activity
0.37	GO:0032559	adenyl ribonucleotide binding
0.37	GO:0008144	drug binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0016887	ATPase activity
0.33	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.32	GO:0004871	signal transducer activity
0.32	GO:0046872	metal ion binding

0.34	GO:0030659	cytoplasmic vesicle membrane
0.34	GO:0030054	cell junction
0.34	GO:0000139	Golgi membrane
0.33	GO:0005856	cytoskeleton
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0016887

tr|T1EDX9|T1EDX9_HELRO
Uncharacterized protein
Search

0.49	GO:0034765	regulation of ion transmembrane transport
0.47	GO:0071805	potassium ion transmembrane transport
0.41	GO:0016310	phosphorylation
0.41	GO:0007165	signal transduction
0.40	GO:0042391	regulation of membrane potential
0.39	GO:0009116	nucleoside metabolic process
0.38	GO:0043547	positive regulation of GTPase activity
0.37	GO:0036211	protein modification process
0.36	GO:0044267	cellular protein metabolic process
0.35	GO:0006351	transcription, DNA-templated

0.52	GO:0005216	ion channel activity
0.48	GO:0022832	voltage-gated channel activity
0.47	GO:0015079	potassium ion transmembrane transporter activity
0.42	GO:0016301	kinase activity
0.38	GO:0005096	GTPase activator activity
0.37	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.36	GO:0046872	metal ion binding
0.36	GO:0140096	catalytic activity, acting on a protein
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding

0.38	GO:0005887	integral component of plasma membrane
0.36	GO:0005634	nucleus

0.37

GO:0016773

tr|T1EDY0|T1EDY0_HELRO
Uncharacterized protein
Search

PRPF4

0.70	Pre-mRNA processing factor 4

0.48	GO:0000398	mRNA splicing, via spliceosome
0.43	GO:0060041	retina development in camera-type eye
0.42	GO:0043009	chordate embryonic development
0.34	GO:0006468	protein phosphorylation

0.53	GO:0030621	U4 snRNA binding
0.52	GO:0017070	U6 snRNA binding
0.38	GO:0016905	myosin heavy chain kinase activity
0.33	GO:0005515	protein binding

0.63	GO:0019013	viral nucleocapsid
0.59	GO:0030529	intracellular ribonucleoprotein complex
0.55	GO:0120114	Sm-like protein family complex
0.54	GO:0015030	Cajal body
0.52	GO:0016607	nuclear speck
0.30	GO:0031224	intrinsic component of membrane

0.38

GO:0016905

tr|T1EDY1|T1EDY1_HELRO
Uncharacterized protein
Search

DPY19L1

0.58	Dpy-19-like C-mannosyltransferase 1

0.59	GO:0097502	mannosylation
0.56	GO:0018317	protein C-linked glycosylation via tryptophan
0.50	GO:0007286	spermatid development
0.34	GO:0007275	multicellular organism development

0.59	GO:0000030	mannosyltransferase activity
0.32	GO:0003676	nucleic acid binding

0.53	GO:0005637	nuclear inner membrane
0.36	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.59

GO:0000030

tr|T1EDY2|T1EDY2_HELRO
Uncharacterized protein
Search

SNX2

0.85	Sorting nexin 2

0.69	GO:0006886	intracellular protein transport
0.69	GO:0042147	retrograde transport, endosome to Golgi
0.61	GO:0006897	endocytosis
0.58	GO:0072673	lamellipodium morphogenesis
0.49	GO:0048193	Golgi vesicle transport
0.47	GO:0043112	receptor metabolic process
0.46	GO:0016050	vesicle organization
0.42	GO:0051259	protein oligomerization
0.36	GO:0045732	positive regulation of protein catabolic process
0.36	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway

0.77	GO:0035091	phosphatidylinositol binding
0.57	GO:1990460	leptin receptor binding
0.56	GO:1990459	transferrin receptor binding
0.55	GO:0005158	insulin receptor binding
0.55	GO:0005154	epidermal growth factor receptor binding
0.52	GO:0045296	cadherin binding
0.49	GO:0042803	protein homodimerization activity
0.49	GO:0046982	protein heterodimerization activity

0.80	GO:0030904	retromer complex
0.59	GO:0005829	cytosol
0.53	GO:0010008	endosome membrane
0.51	GO:0005764	lysosome
0.48	GO:0005769	early endosome
0.44	GO:0019898	extrinsic component of membrane
0.41	GO:0030027	lamellipodium
0.37	GO:0005794	Golgi apparatus
0.36	GO:0043197	dendritic spine
0.35	GO:0014069	postsynaptic density

tr|T1EDY3|T1EDY3_HELRO
Uncharacterized protein
Search

EFTUD2

0.85	Elongation factor Tu GTP-binding domain-containing protein 2

0.43	GO:0006414	translational elongation
0.41	GO:0008380	RNA splicing
0.40	GO:0006397	mRNA processing
0.40	GO:0043010	camera-type eye development
0.40	GO:0045664	regulation of neuron differentiation
0.39	GO:0060322	head development
0.39	GO:0048666	neuron development
0.38	GO:0042220	response to cocaine
0.37	GO:0035690	cellular response to drug
0.34	GO:0046579	positive regulation of Ras protein signal transduction

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0032561	guanyl ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0003746	translation elongation factor activity
0.33	GO:0005515	protein binding

0.55	GO:0019013	viral nucleocapsid
0.53	GO:0030529	intracellular ribonucleoprotein complex
0.53	GO:0015030	Cajal body
0.52	GO:0120114	Sm-like protein family complex
0.50	GO:0016607	nuclear speck
0.46	GO:0005829	cytosol
0.43	GO:1902494	catalytic complex
0.36	GO:0031012	extracellular matrix
0.33	GO:0019867	outer membrane

tr|T1EDY4|T1EDY4_HELRO
Uncharacterized protein
Search

0.79	NFKB activating protein like

0.82	GO:0007219	Notch signaling pathway
0.72	GO:0045892	negative regulation of transcription, DNA-templated
0.47	GO:0046638	positive regulation of alpha-beta T cell differentiation
0.46	GO:1903955	positive regulation of protein targeting to mitochondrion
0.42	GO:0071425	hematopoietic stem cell proliferation
0.41	GO:0030851	granulocyte differentiation
0.41	GO:0033077	T cell differentiation in thymus
0.40	GO:0019827	stem cell population maintenance
0.38	GO:0006357	regulation of transcription by RNA polymerase II
0.35	GO:0016571	histone methylation

0.77	GO:0003682	chromatin binding
0.35	GO:0003677	DNA binding
0.33	GO:0003723	RNA binding
0.33	GO:0005515	protein binding

0.42	GO:0005654	nucleoplasm
0.41	GO:0005829	cytosol
0.36	GO:0031519	PcG protein complex
0.35	GO:0034708	methyltransferase complex
0.34	GO:0071013	catalytic step 2 spliceosome
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDY5|T1EDY5_HELRO
Uncharacterized protein
Search

tr|T1EDY6|T1EDY6_HELRO
Uncharacterized protein
Search

UNC-94

0.85	Tropomodulin

0.85	GO:0051694	pointed-end actin filament capping
0.43	GO:0030239	myofibril assembly
0.40	GO:0007015	actin filament organization
0.38	GO:0048821	erythrocyte development
0.35	GO:0048743	positive regulation of skeletal muscle fiber development
0.35	GO:0002119	nematode larval development
0.35	GO:0048741	skeletal muscle fiber development
0.35	GO:0006941	striated muscle contraction
0.35	GO:0009792	embryo development ending in birth or egg hatching
0.34	GO:0030838	positive regulation of actin filament polymerization

0.85	GO:0005523	tropomyosin binding
0.50	GO:0051015	actin filament binding
0.35	GO:0003785	actin monomer binding

0.41	GO:0030016	myofibril
0.38	GO:0005856	cytoskeleton
0.36	GO:0044449	contractile fiber part
0.34	GO:0044448	cell cortex part
0.34	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDY7|T1EDY7_HELRO
Uncharacterized protein
Search

tr|T1EDY8|T1EDY8_HELRO
Uncharacterized protein
Search

0.41	Spectrin beta chain

0.71	GO:0051693	actin filament capping
0.66	GO:0007010	cytoskeleton organization
0.45	GO:0010172	embryonic body morphogenesis
0.45	GO:0046716	muscle cell cellular homeostasis
0.44	GO:0002119	nematode larval development
0.44	GO:0016358	dendrite development
0.42	GO:0040012	regulation of locomotion
0.42	GO:0048666	neuron development
0.37	GO:0006836	neurotransmitter transport
0.37	GO:0043086	negative regulation of catalytic activity

0.74	GO:0003779	actin binding
0.72	GO:0005200	structural constituent of cytoskeleton
0.66	GO:0005543	phospholipid binding
0.39	GO:0008073	ornithine decarboxylase inhibitor activity
0.38	GO:0005328	neurotransmitter:sodium symporter activity
0.33	GO:0016787	hydrolase activity

0.80	GO:0008091	spectrin
0.45	GO:0031430	M band
0.44	GO:0016328	lateral plasma membrane
0.44	GO:0031674	I band
0.43	GO:0008305	integrin complex
0.41	GO:0030054	cell junction
0.37	GO:0005794	Golgi apparatus

0.33

GO:0016787

tr|T1EDY9|T1EDY9_HELRO
Uncharacterized protein
Search

DDX3X

0.89	DEAD-box helicase 3, X-linked

0.46	GO:1903608	protein localization to cytoplasmic stress granule
0.46	GO:0071243	cellular response to arsenic-containing substance
0.45	GO:0010501	RNA secondary structure unwinding
0.45	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
0.45	GO:0045070	positive regulation of viral genome replication
0.45	GO:0034063	stress granule assembly
0.45	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
0.44	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway
0.44	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.44	GO:0090263	positive regulation of canonical Wnt signaling pathway

0.66	GO:0004386	helicase activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0003676	nucleic acid binding
0.47	GO:0043273	CTPase activity
0.45	GO:0008190	eukaryotic initiation factor 4E binding
0.45	GO:0043024	ribosomal small subunit binding
0.44	GO:0043539	protein serine/threonine kinase activator activity

0.44	GO:0036464	cytoplasmic ribonucleoprotein granule
0.43	GO:0022627	cytosolic small ribosomal subunit
0.42	GO:0005852	eukaryotic translation initiation factor 3 complex
0.41	GO:0005634	nucleus
0.39	GO:0070013	intracellular organelle lumen
0.38	GO:0070062	extracellular exosome
0.37	GO:0005741	mitochondrial outer membrane
0.36	GO:0101002	ficolin-1-rich granule
0.36	GO:0031983	vesicle lumen
0.35	GO:0044433	cytoplasmic vesicle part

tr|T1EDZ0|T1EDZ0_HELRO
Actin-related protein 2/3 complex subunit 5
Search

ARPC5L

0.72	Actin-related protein 2/3 complex subunit 5

0.81	GO:0034314	Arp2/3 complex-mediated actin nucleation
0.46	GO:0016477	cell migration
0.34	GO:0000147	actin cortical patch assembly
0.34	GO:0000001	mitochondrion inheritance
0.34	GO:0006909	phagocytosis
0.33	GO:0006887	exocytosis

0.46	GO:0051015	actin filament binding
0.39	GO:0005200	structural constituent of cytoskeleton
0.33	GO:0003729	mRNA binding

0.80	GO:0005885	Arp2/3 protein complex
0.40	GO:0030027	lamellipodium
0.37	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.36	GO:0005737	cytoplasm
0.34	GO:0098805	whole membrane
0.34	GO:0098588	bounding membrane of organelle
0.33	GO:0031312	extrinsic component of organelle membrane
0.33	GO:0012506	vesicle membrane
0.33	GO:0097708	intracellular vesicle

tr|T1EDZ1|T1EDZ1_HELRO
Uncharacterized protein
Search

0.38	GO:0010951	negative regulation of endopeptidase activity
0.37	GO:0007229	integrin-mediated signaling pathway
0.37	GO:0015074	DNA integration
0.34	GO:0055114	oxidation-reduction process

0.60	GO:0005509	calcium ion binding
0.49	GO:0005201	extracellular matrix structural constituent
0.38	GO:0004867	serine-type endopeptidase inhibitor activity
0.34	GO:0003676	nucleic acid binding

0.56	GO:0005581	collagen trimer
0.47	GO:0005578	proteinaceous extracellular matrix
0.30	GO:0016020	membrane

tr|T1EDZ2|T1EDZ2_HELRO
Uncharacterized protein
Search

0.84	Heat shock protein 4 like

0.46	GO:1903750	regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
0.46	GO:1903753	negative regulation of p38MAPK cascade
0.46	GO:1903748	negative regulation of establishment of protein localization to mitochondrion
0.46	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
0.45	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
0.44	GO:0061098	positive regulation of protein tyrosine kinase activity
0.44	GO:0051085	chaperone cofactor-dependent protein refolding
0.43	GO:0045040	protein import into mitochondrial outer membrane
0.43	GO:0051131	chaperone-mediated protein complex assembly
0.42	GO:0045944	positive regulation of transcription by RNA polymerase II

0.54	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0043014	alpha-tubulin binding
0.43	GO:0000774	adenyl-nucleotide exchange factor activity
0.34	GO:0032440	2-alkenal reductase [NAD(P)] activity

0.46	GO:0005829	cytosol
0.43	GO:0070062	extracellular exosome
0.41	GO:0005874	microtubule
0.41	GO:0005654	nucleoplasm
0.38	GO:0043234	protein complex

0.34

GO:0032440

tr|T1EDZ3|T1EDZ3_HELRO
Uncharacterized protein
Search

DDX11

0.95	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11

0.70	GO:1990700	nucleolar chromatin organization
0.70	GO:0032392	DNA geometric change
0.67	GO:1901836	regulation of transcription of nucleolar large rRNA by RNA polymerase I
0.63	GO:1904976	cellular response to bleomycin
0.62	GO:0072719	cellular response to cisplatin
0.62	GO:0072711	cellular response to hydroxyurea
0.61	GO:0032079	positive regulation of endodeoxyribonuclease activity
0.61	GO:0035563	positive regulation of chromatin binding
0.61	GO:0045876	positive regulation of sister chromatid cohesion
0.60	GO:2000781	positive regulation of double-strand break repair

0.72	GO:0004003	ATP-dependent DNA helicase activity
0.62	GO:0045142	triplex DNA binding
0.60	GO:0051880	G-quadruplex DNA binding
0.55	GO:0003727	single-stranded RNA binding
0.55	GO:0030554	adenyl nucleotide binding
0.55	GO:0003688	DNA replication origin binding
0.54	GO:0003682	chromatin binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005634	nucleus
0.57	GO:0031390	Ctf18 RFC-like complex
0.57	GO:0030496	midbody
0.55	GO:0000922	spindle pole
0.54	GO:0005813	centrosome
0.51	GO:0000785	chromatin
0.49	GO:0031974	membrane-enclosed lumen
0.38	GO:0030892	mitotic cohesin complex
0.36	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

tr|T1EDZ4|T1EDZ4_HELRO
Uncharacterized protein
Search

REXO1

0.55	RNA exonuclease

0.55	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.34	GO:0006744	ubiquinone biosynthetic process
0.33	GO:0032259	methylation
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression
0.32	GO:0016070	RNA metabolic process

0.58	GO:0004527	exonuclease activity
0.51	GO:0003676	nucleic acid binding
0.39	GO:0046872	metal ion binding
0.35	GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity
0.34	GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity
0.34	GO:0030580	quinone cofactor methyltransferase activity
0.33	GO:0004523	RNA-DNA hybrid ribonuclease activity

0.40	GO:0016604	nuclear body
0.34	GO:0031314	extrinsic component of mitochondrial inner membrane
0.30	GO:0031224	intrinsic component of membrane

0.35

EC:2.1.1.114

GO:0004395

tr|T1EDZ5|T1EDZ5_HELRO
Uncharacterized protein
Search

0.10	Inhibitor of Bruton agammaglobulinemia tyrosine kinase (Fragment)

0.56	GO:0016310	phosphorylation
0.50	GO:0061099	negative regulation of protein tyrosine kinase activity
0.48	GO:0051209	release of sequestered calcium ion into cytosol

0.58	GO:0016301	kinase activity
0.51	GO:0030292	protein tyrosine kinase inhibitor activity
0.46	GO:0019901	protein kinase binding

0.44	GO:0005654	nucleoplasm
0.37	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EDZ6|T1EDZ6_HELRO
Uncharacterized protein
Search

INO80

0.86	INO80 complex subunit

0.77	GO:0006338	chromatin remodeling
0.67	GO:0010571	positive regulation of nuclear cell cycle DNA replication
0.65	GO:0070914	UV-damage excision repair
0.65	GO:0071479	cellular response to ionizing radiation
0.63	GO:0030307	positive regulation of cell growth
0.63	GO:2000045	regulation of G1/S transition of mitotic cell cycle
0.62	GO:0051225	spindle assembly
0.60	GO:0000070	mitotic sister chromatid segregation
0.59	GO:0000724	double-strand break repair via homologous recombination
0.58	GO:0045944	positive regulation of transcription by RNA polymerase II

0.66	GO:0043014	alpha-tubulin binding
0.63	GO:0004386	helicase activity
0.60	GO:0016887	ATPase activity
0.54	GO:0030554	adenyl nucleotide binding
0.54	GO:0003677	DNA binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0140097	catalytic activity, acting on DNA
0.37	GO:0003779	actin binding

0.79	GO:0031011	Ino80 complex
0.61	GO:0045111	intermediate filament cytoskeleton
0.60	GO:0016604	nuclear body
0.46	GO:0005886	plasma membrane
0.37	GO:0005874	microtubule
0.34	GO:0005747	mitochondrial respiratory chain complex I

0.60

GO:0016887

tr|T1EDZ7|T1EDZ7_HELRO
Secretory carrier-associated membrane protein
Search

0.52	Secretory carrier-associated membrane protein

0.65

GO:0015031

protein transport

0.44

GO:0031625

ubiquitin protein ligase binding

0.40	GO:0032588	trans-Golgi network membrane
0.40	GO:0055038	recycling endosome membrane
0.30	GO:0016021	integral component of membrane

tr|T1EDZ8|T1EDZ8_HELRO
Alpha-1,4 glucan phosphorylase
Search

0.43	Alpha-1,4 glucan phosphorylase

0.60	GO:0005975	carbohydrate metabolic process
0.43	GO:0006112	energy reserve metabolic process
0.42	GO:0070266	necroptotic process
0.41	GO:0042593	glucose homeostasis
0.38	GO:0009057	macromolecule catabolic process
0.37	GO:0044248	cellular catabolic process
0.35	GO:0044260	cellular macromolecule metabolic process
0.35	GO:0043312	neutrophil degranulation
0.34	GO:0046391	5-phosphoribose 1-diphosphate metabolic process
0.33	GO:0046390	ribose phosphate biosynthetic process

0.80	GO:0102250	linear malto-oligosaccharide phosphorylase activity
0.80	GO:0102499	SHG alpha-glucan phosphorylase activity
0.80	GO:0008184	glycogen phosphorylase activity
0.67	GO:0030170	pyridoxal phosphate binding
0.43	GO:0002060	purine nucleobase binding
0.42	GO:0032052	bile acid binding
0.41	GO:0016208	AMP binding
0.35	GO:0005524	ATP binding
0.34	GO:0005536	glucose binding
0.34	GO:0042803	protein homodimerization activity

0.40	GO:0005789	endoplasmic reticulum membrane
0.35	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0034774	secretory granule lumen
0.34	GO:0070062	extracellular exosome
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1EDZ9|T1EDZ9_HELRO
Uncharacterized protein
Search

MOB3A

0.85	Mps one binder kinase activator

0.53	GO:0016310	phosphorylation
0.35	GO:0007186	G-protein coupled receptor signaling pathway
0.34	GO:0006464	cellular protein modification process

0.56	GO:0016301	kinase activity
0.35	GO:0046872	metal ion binding
0.35	GO:0004930	G-protein coupled receptor activity
0.34	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.34	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.36	GO:0005622	intracellular
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0016773

tr|T1EE00|T1EE00_HELRO
Innexin
Search

INX

0.40

Innexin

0.59

GO:0006811

ion transport

0.81	GO:0005921	gap junction
0.56	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1EE01|T1EE01_HELRO
Uncharacterized protein
Search

TMEM19

0.45	Transmembrane protein 19

0.33	GO:0006266	DNA ligation
0.33	GO:0006310	DNA recombination
0.33	GO:0006281	DNA repair

0.33	GO:0003910	DNA ligase (ATP) activity
0.32	GO:0008270	zinc ion binding
0.32	GO:0003677	DNA binding

0.32	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:6.5.1.1

GO:0003910

tr|T1EE02|T1EE02_HELRO
Uncharacterized protein
Search

PEPCK

0.47	Phosphoenolpyruvate carboxykinase GTP

0.73	GO:0006094	gluconeogenesis
0.50	GO:0016310	phosphorylation

0.83	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032553	ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0016301	kinase activity
0.33	GO:0046872	metal ion binding

0.38	GO:0055120	striated muscle dense body
0.33	GO:0005829	cytosol
0.33	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.83

EC:4.1.1.32

GO:0004613

tr|T1EE03|T1EE03_HELRO
Calcium-transporting ATPase
Search

0.59	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type

0.77	GO:0070588	calcium ion transmembrane transport
0.69	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.41	GO:0044057	regulation of system process
0.41	GO:0090076	relaxation of skeletal muscle
0.39	GO:0009612	response to mechanical stimulus
0.39	GO:0051241	negative regulation of multicellular organismal process
0.38	GO:0006874	cellular calcium ion homeostasis
0.37	GO:0001947	heart looping
0.35	GO:0051240	positive regulation of multicellular organismal process

0.80	GO:0005388	calcium-transporting ATPase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005509	calcium ion binding

0.37	GO:0016529	sarcoplasmic reticulum
0.37	GO:0031673	H zone
0.36	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.36	GO:0031674	I band
0.36	GO:0005789	endoplasmic reticulum membrane
0.35	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0098588	bounding membrane of organelle
0.30	GO:0031224	intrinsic component of membrane

0.80

EC:3.6.3.8

GO:0005388

tr|T1EE04|T1EE04_HELRO
Uncharacterized protein
Search

LOC100184515

0.50	Mitogen-activated protein kinase kinase kinase kinase

0.61	GO:0006468	protein phosphorylation
0.59	GO:0000185	activation of MAPKKK activity
0.48	GO:0035556	intracellular signal transduction
0.43	GO:0048812	neuron projection morphogenesis
0.41	GO:0001748	optic lobe placode development
0.41	GO:0046529	imaginal disc fusion, thorax closure
0.41	GO:0008594	photoreceptor cell morphogenesis
0.40	GO:0016476	regulation of embryonic cell shape
0.40	GO:0007391	dorsal closure
0.40	GO:0007097	nuclear migration

0.62	GO:0004672	protein kinase activity
0.55	GO:0005057	signal transducer activity, downstream of receptor
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding

0.38	GO:0005622	intracellular
0.35	GO:0071944	cell periphery

tr|T1EE05|T1EE05_HELRO
Uncharacterized protein
Search

CPA5

0.41	Carboxypeptidase B

0.61	GO:0006508	proteolysis
0.41	GO:0002002	regulation of angiotensin levels in blood
0.37	GO:0042730	fibrinolysis
0.34	GO:2000346	negative regulation of hepatocyte proliferation
0.34	GO:0003331	positive regulation of extracellular matrix constituent secretion
0.34	GO:0010757	negative regulation of plasminogen activation
0.34	GO:0051918	negative regulation of fibrinolysis
0.34	GO:0097421	liver regeneration
0.34	GO:0071333	cellular response to glucose stimulus
0.34	GO:0007596	blood coagulation

0.78	GO:0004181	metallocarboxypeptidase activity
0.63	GO:0008270	zinc ion binding
0.33	GO:0005328	neurotransmitter:sodium symporter activity
0.33	GO:0005254	chloride channel activity

0.42	GO:0044421	extracellular region part
0.34	GO:0030141	secretory granule
0.33	GO:0030133	transport vesicle
0.33	GO:0034707	chloride channel complex
0.32	GO:0005886	plasma membrane

0.78

GO:0004181

tr|T1EE06|T1EE06_HELRO
Uncharacterized protein
Search

0.56	Partitioning defective protein 6

0.78	GO:0007163	establishment or maintenance of cell polarity
0.55	GO:1904781	positive regulation of protein localization to centrosome
0.54	GO:0045217	cell-cell junction maintenance
0.52	GO:0001933	negative regulation of protein phosphorylation
0.51	GO:0007098	centrosome cycle
0.48	GO:0007430	terminal branching, open tracheal system
0.47	GO:0010592	positive regulation of lamellipodium assembly
0.47	GO:0055059	asymmetric neuroblast division
0.47	GO:0051491	positive regulation of filopodium assembly
0.46	GO:0007298	border follicle cell migration

0.54	GO:0005080	protein kinase C binding
0.54	GO:0030742	GTP-dependent protein binding
0.50	GO:0017048	Rho GTPase binding
0.34	GO:0016780	phosphotransferase activity, for other substituted phosphate groups
0.34	GO:0008134	transcription factor binding
0.34	GO:0005509	calcium ion binding
0.34	GO:0004252	serine-type endopeptidase activity

0.53	GO:0005938	cell cortex
0.53	GO:0034451	centriolar satellite
0.51	GO:0043296	apical junction complex
0.50	GO:0070160	occluding junction
0.48	GO:0097482	muscle cell postsynaptic specialization
0.46	GO:0043195	terminal bouton
0.45	GO:0016324	apical plasma membrane
0.42	GO:0005634	nucleus
0.42	GO:0043234	protein complex
0.35	GO:0044295	axonal growth cone

0.34

EC:2.7.8

GO:0016780

tr|T1EE07|T1EE07_HELRO
Mitogen-activated protein kinase
Search

0.58	Mitogen-activated protein kinase

0.79	GO:0000165	MAPK cascade
0.46	GO:0048082	regulation of adult chitin-containing cuticle pigmentation
0.46	GO:0038001	paracrine signaling
0.46	GO:0071243	cellular response to arsenic-containing substance
0.45	GO:0045793	positive regulation of cell size
0.45	GO:0071276	cellular response to cadmium ion
0.44	GO:1900407	regulation of cellular response to oxidative stress
0.44	GO:0008340	determination of adult lifespan
0.44	GO:0042542	response to hydrogen peroxide
0.44	GO:0050832	defense response to fungus

0.81	GO:0004707	MAP kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0008408	3'-5' exonuclease activity
0.32	GO:0003676	nucleic acid binding

0.45	GO:0005622	intracellular
0.37	GO:0043227	membrane-bounded organelle

0.81	EC:2.7.11.24	GO:0004707
0.81	KEGG:R00162	GO:0004707

tr|T1EE08|T1EE08_HELRO
Ribonucleoside-diphosphate reductase
Search

0.54	Ribonucleoside-diphosphate reductase

0.66	GO:0006260	DNA replication
0.53	GO:0055114	oxidation-reduction process
0.37	GO:0031288	sorocarp morphogenesis
0.36	GO:0009202	deoxyribonucleoside triphosphate biosynthetic process
0.36	GO:0046686	response to cadmium ion
0.35	GO:0046062	dCDP metabolic process
0.35	GO:0046704	CDP metabolic process
0.35	GO:0009263	deoxyribonucleotide biosynthetic process
0.34	GO:0009197	pyrimidine deoxyribonucleoside diphosphate biosynthetic process
0.34	GO:0046075	dTTP metabolic process

0.77	GO:0061731	ribonucleoside-diphosphate reductase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0004550	nucleoside diphosphate kinase activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0032561	guanyl ribonucleotide binding
0.33	GO:0015035	protein disulfide oxidoreductase activity

0.36	GO:0005971	ribonucleoside-diphosphate reductase complex
0.30	GO:0016020	membrane

0.34

EC:2.7.4.6

GO:0004550

tr|T1EE09|T1EE09_HELRO
Uncharacterized protein
Search

VPS16

0.62	Vacuolar protein sorting-associated protein 16

0.80	GO:0007033	vacuole organization
0.69	GO:0006886	intracellular protein transport
0.54	GO:0097352	autophagosome maturation
0.53	GO:0008333	endosome to lysosome transport
0.49	GO:0032889	regulation of vacuole fusion, non-autophagic
0.49	GO:0035542	regulation of SNARE complex assembly
0.39	GO:0008057	eye pigment granule organization
0.38	GO:0045746	negative regulation of Notch signaling pathway
0.37	GO:0009267	cellular response to starvation
0.34	GO:0051806	entry into cell of other organism involved in symbiotic interaction

0.44	GO:0003779	actin binding
0.37	GO:0019905	syntaxin binding
0.36	GO:0032403	protein complex binding
0.32	GO:0016301	kinase activity

0.57	GO:0030897	HOPS complex
0.53	GO:0005764	lysosome
0.51	GO:0005768	endosome
0.46	GO:0098852	lytic vacuole membrane
0.40	GO:0005776	autophagosome
0.37	GO:0030136	clathrin-coated vesicle
0.37	GO:0044433	cytoplasmic vesicle part
0.37	GO:0043025	neuronal cell body
0.36	GO:0030424	axon
0.36	GO:0005884	actin filament

tr|T1EE10|T1EE10_HELRO
Uncharacterized protein
Search

0.84	Ovalbumin upstream promoter-transcription factor I

0.80	GO:0030522	intracellular receptor signaling pathway
0.79	GO:0043401	steroid hormone mediated signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.49	GO:0072359	circulatory system development
0.48	GO:1902679	negative regulation of RNA biosynthetic process
0.46	GO:0048699	generation of neurons
0.46	GO:0060839	endothelial cell fate commitment

0.82	GO:0004879	nuclear receptor activity
0.80	GO:0003707	steroid hormone receptor activity
0.64	GO:0043565	sequence-specific DNA binding
0.62	GO:0008270	zinc ion binding
0.49	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.45	GO:0001972	retinoic acid binding
0.45	GO:0001012	RNA polymerase II regulatory region DNA binding
0.44	GO:0042803	protein homodimerization activity
0.43	GO:0003690	double-stranded DNA binding
0.38	GO:0046982	protein heterodimerization activity

0.61	GO:0005634	nucleus
0.45	GO:0005829	cytosol
0.45	GO:0070013	intracellular organelle lumen
0.41	GO:0044446	intracellular organelle part

tr|T1EE11|T1EE11_HELRO
Uncharacterized protein
Search

0.59	Transmembrane protein 260

0.45

GO:0007417

central nervous system development

0.30

GO:0044425

membrane part

tr|T1EE12|T1EE12_HELRO
Eyes absent homolog
Search

0.55	Eyes absent homolog

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.73	GO:0042471	ear morphogenesis
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.54	GO:0016576	histone dephosphorylation
0.53	GO:0072513	positive regulation of secondary heart field cardioblast proliferation
0.53	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
0.52	GO:0045739	positive regulation of DNA repair
0.52	GO:0007501	mesodermal cell fate specification

0.75	GO:0004725	protein tyrosine phosphatase activity
0.54	GO:0046872	metal ion binding
0.41	GO:0003723	RNA binding
0.34	GO:0005515	protein binding

0.49	GO:0016604	nuclear body
0.45	GO:0032993	protein-DNA complex
0.41	GO:0043234	protein complex
0.37	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.75

GO:0004725

tr|T1EE13|T1EE13_HELRO
Uncharacterized protein
Search

0.66	Inward rectifier potassium channel

0.78	GO:0034765	regulation of ion transmembrane transport
0.71	GO:0006813	potassium ion transport
0.61	GO:0098655	cation transmembrane transport
0.37	GO:0045475	locomotor rhythm
0.37	GO:0035220	wing disc development
0.36	GO:0042391	regulation of membrane potential
0.34	GO:0098660	inorganic ion transmembrane transport
0.34	GO:0006836	neurotransmitter transport
0.30	GO:0009987	cellular process

0.84	GO:0005242	inward rectifier potassium channel activity
0.34	GO:0005328	neurotransmitter:sodium symporter activity

0.35	GO:0005887	integral component of plasma membrane
0.33	GO:0005840	ribosome

tr|T1EE14|T1EE14_HELRO
Uncharacterized protein
Search

DDX17

0.87	DEAD (Asp-Glu-Ala-Asp) box helicase 17

0.45	GO:0010501	RNA secondary structure unwinding
0.42	GO:0000398	mRNA splicing, via spliceosome
0.42	GO:0045893	positive regulation of transcription, DNA-templated
0.39	GO:0010586	miRNA metabolic process
0.39	GO:2001014	regulation of skeletal muscle cell differentiation
0.39	GO:0030520	intracellular estrogen receptor signaling pathway
0.39	GO:0030521	androgen receptor signaling pathway
0.39	GO:0045445	myoblast differentiation
0.38	GO:0001837	epithelial to mesenchymal transition
0.38	GO:0000381	regulation of alternative mRNA splicing, via spliceosome

0.67	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.43	GO:0008186	RNA-dependent ATPase activity
0.39	GO:0140098	catalytic activity, acting on RNA
0.37	GO:0003713	transcription coactivator activity
0.34	GO:0005515	protein binding
0.33	GO:0008094	DNA-dependent ATPase activity

0.42	GO:0005730	nucleolus
0.36	GO:0016607	nuclear speck
0.35	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

tr|T1EE15|T1EE15_HELRO
Uncharacterized protein
Search

0.66	Maternal protein pumilio

0.48	GO:1900246	positive regulation of RIG-I signaling pathway
0.48	GO:0061013	regulation of mRNA catabolic process
0.48	GO:0016441	posttranscriptional gene silencing
0.47	GO:2000637	positive regulation of gene silencing by miRNA
0.47	GO:0034063	stress granule assembly
0.46	GO:0070918	production of small RNA involved in gene silencing by RNA
0.46	GO:0043487	regulation of RNA stability
0.45	GO:0051983	regulation of chromosome segregation
0.44	GO:0017148	negative regulation of translation
0.41	GO:0007280	pole cell migration

0.59	GO:0003723	RNA binding
0.34	GO:0000900	translation repressor activity, nucleic acid binding

0.46	GO:0005635	nuclear envelope
0.45	GO:0010494	cytoplasmic stress granule
0.44	GO:0048471	perinuclear region of cytoplasm
0.42	GO:0005829	cytosol
0.41	GO:0061177	type Is terminal bouton
0.41	GO:0061176	type Ib terminal bouton
0.41	GO:0097482	muscle cell postsynaptic specialization
0.39	GO:0031090	organelle membrane
0.32	GO:0000932	P-body

tr|T1EE16|T1EE16_HELRO
Uncharacterized protein
Search

0.47	Target of rapamycin complex subunit lst8

0.82	GO:0031929	TOR signaling
0.81	GO:0032008	positive regulation of TOR signaling
0.51	GO:0031930	mitochondria-nucleus signaling pathway
0.50	GO:0030950	establishment or maintenance of actin cytoskeleton polarity
0.49	GO:0032147	activation of protein kinase activity
0.49	GO:0031505	fungal-type cell wall organization
0.48	GO:0001558	regulation of cell growth
0.44	GO:0032956	regulation of actin cytoskeleton organization
0.40	GO:1900091	regulation of raffinose biosynthetic process
0.39	GO:1900088	regulation of inositol biosynthetic process

0.49	GO:0030295	protein kinase activator activity
0.37	GO:0016905	myosin heavy chain kinase activity
0.35	GO:0005515	protein binding
0.34	GO:0051537	2 iron, 2 sulfur cluster binding
0.33	GO:0004197	cysteine-type endopeptidase activity
0.33	GO:0009055	electron transfer activity
0.32	GO:0046872	metal ion binding
0.32	GO:0004721	phosphoprotein phosphatase activity

0.83	GO:0031931	TORC1 complex
0.82	GO:0031932	TORC2 complex
0.49	GO:0034399	nuclear periphery
0.48	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.48	GO:0005768	endosome
0.46	GO:0044433	cytoplasmic vesicle part
0.46	GO:0000139	Golgi membrane
0.45	GO:0098805	whole membrane
0.38	GO:0005776	autophagosome
0.37	GO:0031252	cell leading edge

0.37

GO:0016905

tr|T1EE17|T1EE17_HELRO
Uncharacterized protein
Search

ERP44

0.40	Thioredoxin domain-containing 4

0.69	GO:0045454	cell redox homeostasis
0.54	GO:0034976	response to endoplasmic reticulum stress
0.53	GO:0006986	response to unfolded protein
0.50	GO:0009100	glycoprotein metabolic process
0.49	GO:0006457	protein folding
0.42	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling
0.40	GO:0007507	heart development
0.36	GO:0043312	neutrophil degranulation

0.56	GO:0003756	protein disulfide isomerase activity
0.34	GO:0005515	protein binding

0.54	GO:0005788	endoplasmic reticulum lumen
0.54	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.50	GO:0009986	cell surface
0.49	GO:0005789	endoplasmic reticulum membrane
0.37	GO:0070062	extracellular exosome
0.36	GO:0035580	specific granule lumen
0.30	GO:0016021	integral component of membrane

0.56

EC:5.3.4.1

GO:0003756

tr|T1EE18|T1EE18_HELRO
Uncharacterized protein
Search

0.75	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

0.59	GO:0060352	cell adhesion molecule production
0.57	GO:0050901	leukocyte tethering or rolling
0.55	GO:0060993	kidney morphogenesis
0.52	GO:0048729	tissue morphogenesis
0.50	GO:0009101	glycoprotein biosynthetic process
0.38	GO:0043413	macromolecule glycosylation
0.38	GO:0002426	immunoglobulin production in mucosal tissue
0.38	GO:0032868	response to insulin
0.37	GO:0050892	intestinal absorption
0.35	GO:0006464	cellular protein modification process

0.77	GO:0008375	acetylglucosaminyltransferase activity
0.44	GO:0140103	catalytic activity, acting on a glycoprotein
0.33	GO:0005515	protein binding

0.53	GO:0031985	Golgi cisterna
0.52	GO:0005802	trans-Golgi network
0.38	GO:0000139	Golgi membrane
0.36	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane

0.77

GO:0008375

tr|T1EE19|T1EE19_HELRO
Uncharacterized protein
Search

0.54	GO:0007219	Notch signaling pathway
0.48	GO:0007275	multicellular organism development
0.46	GO:0006898	receptor-mediated endocytosis
0.45	GO:0030154	cell differentiation
0.43	GO:0050793	regulation of developmental process
0.39	GO:0045967	negative regulation of growth rate
0.39	GO:0009653	anatomical structure morphogenesis
0.38	GO:0060255	regulation of macromolecule metabolic process
0.38	GO:0046849	bone remodeling
0.38	GO:0031323	regulation of cellular metabolic process

0.70	GO:0005509	calcium ion binding
0.55	GO:0005201	extracellular matrix structural constituent
0.49	GO:0005112	Notch binding
0.49	GO:0005044	scavenger receptor activity
0.36	GO:0008061	chitin binding
0.35	GO:0030414	peptidase inhibitor activity
0.34	GO:0070011	peptidase activity, acting on L-amino acid peptides
0.34	GO:0004888	transmembrane signaling receptor activity
0.34	GO:0045545	syndecan binding
0.34	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

0.52	GO:0005578	proteinaceous extracellular matrix
0.37	GO:0009986	cell surface
0.37	GO:0043235	receptor complex
0.36	GO:0005654	nucleoplasm
0.36	GO:0005887	integral component of plasma membrane
0.35	GO:0044420	extracellular matrix component
0.34	GO:0005615	extracellular space
0.33	GO:0099512	supramolecular fiber

0.34

EC:1.14.17

GO:0016715

tr|T1EE20|T1EE20_HELRO
Uncharacterized protein
Search

0.61	GO:0007165	signal transduction
0.46	GO:1904425	negative regulation of GTP binding
0.45	GO:0051497	negative regulation of stress fiber assembly
0.40	GO:0043087	regulation of GTPase activity
0.40	GO:0051345	positive regulation of hydrolase activity
0.34	GO:0051056	regulation of small GTPase mediated signal transduction
0.34	GO:0099120	socially cooperative development
0.33	GO:0007018	microtubule-based movement

0.40	GO:0005096	GTPase activator activity
0.37	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.33	GO:0003777	microtubule motor activity
0.33	GO:0008017	microtubule binding
0.33	GO:0003779	actin binding
0.32	GO:0046872	metal ion binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.33	GO:0005829	cytosol
0.33	GO:0016459	myosin complex
0.30	GO:0016020	membrane

tr|T1EE21|T1EE21_HELRO
Uncharacterized protein
Search

0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:0010468	regulation of gene expression
0.33	GO:0097659	nucleic acid-templated transcription
0.33	GO:0010467	gene expression
0.33	GO:0034645	cellular macromolecule biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.37	GO:0046872	metal ion binding
0.33	GO:0003700	DNA binding transcription factor activity

0.35

GO:0005634

nucleus

tr|T1EE22|T1EE22_HELRO
Uncharacterized protein
Search

0.60	GO:0060913	cardiac cell fate determination
0.59	GO:0048936	peripheral nervous system neuron axonogenesis
0.59	GO:0003139	secondary heart field specification
0.58	GO:0071657	positive regulation of granulocyte colony-stimulating factor production
0.58	GO:0021524	visceral motor neuron differentiation
0.58	GO:0032730	positive regulation of interleukin-1 alpha production
0.57	GO:0048665	neuron fate specification
0.57	GO:0003266	regulation of secondary heart field cardioblast proliferation
0.57	GO:0060379	cardiac muscle cell myoblast differentiation
0.57	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production

0.64	GO:0043565	sequence-specific DNA binding
0.57	GO:0043425	bHLH transcription factor binding
0.56	GO:0001105	RNA polymerase II transcription coactivator activity
0.56	GO:0001102	RNA polymerase II activating transcription factor binding
0.56	GO:0035326	enhancer binding
0.55	GO:1990841	promoter-specific chromatin binding
0.52	GO:0046872	metal ion binding
0.50	GO:0003690	double-stranded DNA binding
0.40	GO:0016922	ligand-dependent nuclear receptor binding
0.40	GO:0030331	estrogen receptor binding

0.61	GO:0005634	nucleus
0.48	GO:0070013	intracellular organelle lumen
0.43	GO:0044446	intracellular organelle part
0.33	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

tr|T1EE23|T1EE23_HELRO
Uncharacterized protein
Search

0.49	Exonuclease 1

0.65	GO:0006281	DNA repair
0.64	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.54	GO:0016446	somatic hypermutation of immunoglobulin genes
0.54	GO:0002204	somatic recombination of immunoglobulin genes involved in immune response
0.53	GO:0002312	B cell activation involved in immune response
0.52	GO:0002455	humoral immune response mediated by circulating immunoglobulin
0.35	GO:0051321	meiotic cell cycle
0.35	GO:0000732	strand displacement
0.35	GO:0001325	formation of extrachromosomal circular DNA
0.35	GO:0090737	telomere maintenance via telomere trimming

0.84	GO:0035312	5'-3' exodeoxyribonuclease activity
0.55	GO:0003677	DNA binding
0.54	GO:0008309	double-stranded DNA exodeoxyribonuclease activity
0.54	GO:0008297	single-stranded DNA exodeoxyribonuclease activity
0.52	GO:0048256	flap endonuclease activity
0.49	GO:0003682	chromatin binding
0.34	GO:0046872	metal ion binding
0.34	GO:0004523	RNA-DNA hybrid ribonuclease activity
0.33	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.33	GO:0005515	protein binding

0.59	GO:0005634	nucleus
0.45	GO:0031974	membrane-enclosed lumen
0.41	GO:0044446	intracellular organelle part
0.41	GO:0005886	plasma membrane
0.33	GO:0005739	mitochondrion

0.34

EC:3.1.26.4

GO:0004523

tr|T1EE24|T1EE24_HELRO
Diacylglycerol kinase
Search

0.18	Diacylglycerol kinase

0.83	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
0.62	GO:0035556	intracellular signal transduction
0.57	GO:0016310	phosphorylation
0.44	GO:0030258	lipid modification
0.43	GO:0046486	glycerolipid metabolic process
0.40	GO:0043052	thermotaxis
0.39	GO:0048169	regulation of long-term neuronal synaptic plasticity
0.39	GO:0042048	olfactory behavior
0.37	GO:0006638	neutral lipid metabolic process
0.35	GO:0008654	phospholipid biosynthetic process

0.80	GO:0004143	diacylglycerol kinase activity
0.74	GO:0003951	NAD+ kinase activity
0.68	GO:0005509	calcium ion binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0005543	phospholipid binding
0.35	GO:0004222	metalloendopeptidase activity

0.45	GO:0005622	intracellular
0.34	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.80	EC:2.7.1.107	GO:0004143
0.74	KEGG:R00104	GO:0003951

tr|T1EE25|T1EE25_HELRO
DNA-directed RNA polymerase subunit
Search

0.10	DNA-directed RNA polymerase subunit

0.58	GO:0006351	transcription, DNA-templated
0.37	GO:0006506	GPI anchor biosynthetic process

0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.55	GO:0003677	DNA binding

0.36	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.70

GO:0003899

tr|T1EE26|T1EE26_HELRO
Uncharacterized protein
Search

DDX1

0.67	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1

0.54	GO:1903608	protein localization to cytoplasmic stress granule
0.52	GO:0043330	response to exogenous dsRNA
0.51	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation
0.49	GO:0009615	response to virus
0.49	GO:0006302	double-strand break repair
0.48	GO:0007275	multicellular organism development
0.46	GO:0032392	DNA geometric change
0.46	GO:0010501	RNA secondary structure unwinding
0.44	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.42	GO:0048477	oogenesis

0.60	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0008143	poly(A) binding
0.49	GO:0003682	chromatin binding
0.49	GO:0003712	transcription cofactor activity
0.48	GO:0003725	double-stranded RNA binding
0.45	GO:0042623	ATPase activity, coupled
0.44	GO:0140098	catalytic activity, acting on RNA

0.56	GO:0071920	cleavage body
0.53	GO:0072669	tRNA-splicing ligase complex
0.51	GO:0010494	cytoplasmic stress granule
0.46	GO:0005829	cytosol
0.43	GO:0005730	nucleolus
0.30	GO:0031224	intrinsic component of membrane

0.44

EC:3.1

GO:0004518

tr|T1EE27|T1EE27_HELRO
Uncharacterized protein
Search

VARS

0.44	Valyl-tRNA synthetase

0.77	GO:0006438	valyl-tRNA aminoacylation
0.73	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity
0.36	GO:0006397	mRNA processing

0.77	GO:0004832	valine-tRNA ligase activity
0.73	GO:0002161	aminoacyl-tRNA editing activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding

0.46	GO:0005829	cytosol
0.41	GO:0005739	mitochondrion
0.35	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0016020	membrane

0.77	EC:6.1.1.9	GO:0004832
0.77	KEGG:R03665	GO:0004832

tr|T1EE28|T1EE28_HELRO
Uncharacterized protein
Search

CCNB2

0.79

Cyclin B

0.52	GO:0043029	T cell homeostasis
0.51	GO:0048538	thymus development
0.48	GO:0040007	growth
0.48	GO:0001701	in utero embryonic development
0.41	GO:0007049	cell cycle
0.41	GO:0051301	cell division
0.36	GO:0051726	regulation of cell cycle
0.35	GO:2000775	histone H3-S10 phosphorylation involved in chromosome condensation
0.35	GO:1905448	positive regulation of mitochondrial ATP synthesis coupled electron transport
0.35	GO:1900194	negative regulation of oocyte maturation

0.50	GO:0045296	cadherin binding
0.35	GO:0005113	patched binding
0.34	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity
0.34	GO:0004693	cyclin-dependent protein serine/threonine kinase activity
0.34	GO:0044389	ubiquitin-like protein ligase binding
0.34	GO:0019901	protein kinase binding
0.34	GO:0016874	ligase activity
0.32	GO:0005198	structural molecule activity
0.32	GO:0003723	RNA binding
0.32	GO:0016787	hydrolase activity

0.61	GO:0005634	nucleus
0.49	GO:0005813	centrosome
0.46	GO:0005829	cytosol
0.35	GO:0097125	cyclin B1-CDK1 complex
0.34	GO:0000940	condensed chromosome outer kinetochore
0.34	GO:0000922	spindle pole
0.34	GO:0005759	mitochondrial matrix
0.33	GO:0005882	intermediate filament
0.30	GO:0016020	membrane

0.34

EC:2.7.11.22

GO:0004693

tr|T1EE29|T1EE29_HELRO
alpha-1,2-Mannosidase
Search

EDEM1

0.47	ER degradation-enhancing alpha-mannosidase-like protein 1

0.55	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol
0.55	GO:0036510	trimming of terminal mannose on C branch
0.54	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway
0.47	GO:0006491	N-glycan processing
0.36	GO:0006986	response to unfolded protein
0.34	GO:0035967	cellular response to topologically incorrect protein
0.33	GO:0007165	signal transduction
0.32	GO:0055085	transmembrane transport

0.82	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
0.70	GO:0005509	calcium ion binding
0.53	GO:0051787	misfolded protein binding
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0032561	guanyl ribonucleotide binding
0.32	GO:0022857	transmembrane transporter activity
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.53	GO:0016235	aggresome
0.53	GO:0044322	endoplasmic reticulum quality control compartment
0.48	GO:0030176	integral component of endoplasmic reticulum membrane
0.44	GO:0000139	Golgi membrane
0.33	GO:0019866	organelle inner membrane
0.33	GO:0031966	mitochondrial membrane

0.82	EC:3.2.1.113	GO:0004571
0.82	KEGG:R05982 KEGG:R06722	GO:0004571

tr|T1EE30|T1EE30_HELRO
Uncharacterized protein
Search

0.71	Major egg antigen

0.85

GO:0005212

structural constituent of eye lens

tr|T1EE31|T1EE31_HELRO
Nucleolar protein 6
Search

0.42	Nucleolar protein 6

0.50	GO:0071431	tRNA-containing ribonucleoprotein complex export from nucleus
0.50	GO:0051031	tRNA transport
0.49	GO:0097064	ncRNA export from nucleus
0.47	GO:0006364	rRNA processing
0.31	GO:0006508	proteolysis

0.59	GO:0003723	RNA binding
0.34	GO:0005515	protein binding
0.32	GO:0004252	serine-type endopeptidase activity

0.72	GO:0005730	nucleolus
0.52	GO:0000794	condensed nuclear chromosome
0.50	GO:0032545	CURI complex
0.47	GO:0030686	90S preribosome
0.47	GO:0032040	small-subunit processome
0.44	GO:0005739	mitochondrion
0.34	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.32

GO:0004252

tr|T1EE32|T1EE32_HELRO
Uncharacterized protein
Search

UPP1

0.55	Uridine phosphorylase

0.72	GO:0009166	nucleotide catabolic process
0.68	GO:0044206	UMP salvage
0.47	GO:0046108	uridine metabolic process
0.44	GO:0046135	pyrimidine nucleoside catabolic process
0.43	GO:0042454	ribonucleoside catabolic process
0.37	GO:0042149	cellular response to glucose starvation
0.33	GO:0043413	macromolecule glycosylation
0.33	GO:0009101	glycoprotein biosynthetic process
0.32	GO:0036211	protein modification process
0.32	GO:0044267	cellular protein metabolic process

0.79	GO:0004850	uridine phosphorylase activity
0.34	GO:0042802	identical protein binding
0.33	GO:0030246	carbohydrate binding

0.48	GO:0005737	cytoplasm
0.46	GO:0045098	type III intermediate filament
0.41	GO:0005654	nucleoplasm
0.33	GO:0012505	endomembrane system
0.30	GO:0016021	integral component of membrane

0.79

EC:2.4.2.3

GO:0004850

tr|T1EE33|T1EE33_HELRO
Proteasome subunit alpha type
Search

PSMA6

0.49	Proteasome endopeptidase complex

0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.49	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.37	GO:0071345	cellular response to cytokine stimulus
0.36	GO:0034341	response to interferon-gamma
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.35	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:1902036	regulation of hematopoietic stem cell differentiation

0.77	GO:0004298	threonine-type endopeptidase activity
0.51	GO:0051059	NF-kappaB binding
0.41	GO:0003723	RNA binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.79	GO:0019773	proteasome core complex, alpha-subunit complex
0.61	GO:0005634	nucleus
0.49	GO:0005737	cytoplasm
0.49	GO:0005844	polysome
0.47	GO:0035770	ribonucleoprotein granule
0.44	GO:0070013	intracellular organelle lumen
0.40	GO:0044446	intracellular organelle part
0.36	GO:0099512	supramolecular fiber
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.77

EC:3.4.25

GO:0004298

tr|T1EE34|T1EE34_HELRO
Uncharacterized protein
Search

0.46	SHANK-associated RH domain interactor

0.59	GO:0097039	protein linear polyubiquitination
0.55	GO:0060546	negative regulation of necroptotic process
0.54	GO:0042346	positive regulation of NF-kappaB import into nucleus
0.53	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
0.53	GO:0050852	T cell receptor signaling pathway
0.52	GO:0032088	negative regulation of NF-kappaB transcription factor activity
0.52	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.51	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.45	GO:0048701	embryonic cranial skeleton morphogenesis
0.44	GO:0071600	otic vesicle morphogenesis

0.54	GO:0043130	ubiquitin binding
0.53	GO:0046872	metal ion binding
0.50	GO:0004842	ubiquitin-protein transferase activity
0.35	GO:0005080	protein kinase C binding
0.34	GO:0003690	double-stranded DNA binding
0.33	GO:0016874	ligase activity
0.33	GO:0003700	DNA binding transcription factor activity
0.33	GO:0016301	kinase activity

0.56	GO:0071797	LUBAC complex
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.33	EC:6	GO:0016874
0.50	KEGG:R03876	GO:0004842

tr|T1EE35|T1EE35_HELRO
Uncharacterized protein
Search

ACAD10

0.40	Aminoglycoside phosphotransferase

0.53	GO:0055114	oxidation-reduction process
0.44	GO:0009062	fatty acid catabolic process
0.43	GO:0030258	lipid modification
0.35	GO:0048767	root hair elongation
0.33	GO:0006468	protein phosphorylation
0.33	GO:0006508	proteolysis

0.68	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
0.66	GO:0050660	flavin adenine dinucleotide binding
0.45	GO:0016787	hydrolase activity
0.34	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.33	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0046872	metal ion binding

0.41	GO:0005739	mitochondrion
0.33	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.68

EC:1.3

GO:0016627

tr|T1EE36|T1EE36_HELRO
Uncharacterized protein
Search

UBA3

0.83	Ubiquitin like modifier activating enzyme 3

0.84	GO:0045116	protein neddylation
0.44	GO:0007113	endomitotic cell cycle
0.41	GO:0045879	negative regulation of smoothened signaling pathway
0.40	GO:0051726	regulation of cell cycle
0.34	GO:0045892	negative regulation of transcription, DNA-templated
0.34	GO:0038061	NIK/NF-kappaB signaling
0.34	GO:0043687	post-translational protein modification
0.34	GO:0070329	tRNA seleno-modification
0.33	GO:0006629	lipid metabolic process
0.33	GO:0006508	proteolysis

0.84	GO:0019781	NEDD8 activating enzyme activity
0.71	GO:0016881	acid-amino acid ligase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0046982	protein heterodimerization activity
0.39	GO:0042802	identical protein binding
0.37	GO:0052689	carboxylic ester hydrolase activity
0.36	GO:0016922	ligand-dependent nuclear receptor binding
0.35	GO:0019788	NEDD8 transferase activity

0.38	GO:0005576	extracellular region
0.37	GO:0005634	nucleus
0.36	GO:0043234	protein complex
0.35	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.71	EC:6.3.2	GO:0016881
0.37	KEGG:R00630	GO:0052689

tr|T1EE37|T1EE37_HELRO
Uncharacterized protein
Search

TMCC2

0.87	Transmembrane and coiled-coil domains protein 2

0.46	GO:0042982	amyloid precursor protein metabolic process
0.41	GO:0007420	brain development
0.34	GO:0051291	protein heterooligomerization
0.34	GO:0007029	endoplasmic reticulum organization
0.34	GO:0051260	protein homooligomerization

0.33	GO:0042803	protein homodimerization activity
0.33	GO:0046982	protein heterodimerization activity

0.42	GO:0005783	endoplasmic reticulum
0.33	GO:0005829	cytosol
0.30	GO:0044425	membrane part

tr|T1EE38|T1EE38_HELRO
Uncharacterized protein
Search

NUDT9

0.41	ADP ribose pyrophosphatase mitochondrial

0.49	GO:0046032	ADP catabolic process
0.49	GO:0046707	IDP metabolic process
0.35	GO:0034220	ion transmembrane transport
0.35	GO:0006952	defense response
0.33	GO:0006979	response to oxidative stress
0.33	GO:0006812	cation transport
0.33	GO:0005975	carbohydrate metabolic process

0.51	GO:0043262	adenosine-diphosphatase activity
0.41	GO:0047631	ADP-ribose diphosphatase activity
0.36	GO:0005216	ion channel activity
0.33	GO:0008324	cation transmembrane transporter activity
0.33	GO:0016773	phosphotransferase activity, alcohol group as acceptor

0.40	GO:0005739	mitochondrion
0.34	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.41

EC:3.6.1.13

GO:0047631

tr|T1EE39|T1EE39_HELRO
Uncharacterized protein
Search

CAPN5

0.89

Calpain-5

0.61	GO:0006508	proteolysis
0.35	GO:0051493	regulation of cytoskeleton organization
0.35	GO:0007608	sensory perception of smell
0.34	GO:0007165	signal transduction
0.34	GO:0043413	macromolecule glycosylation
0.34	GO:0009101	glycoprotein biosynthetic process
0.33	GO:0036211	protein modification process
0.32	GO:0044267	cellular protein metabolic process

0.82	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.34	GO:0008378	galactosyltransferase activity
0.34	GO:0004871	signal transducer activity
0.33	GO:0005509	calcium ion binding

0.45	GO:0009986	cell surface
0.45	GO:0005622	intracellular
0.34	GO:0005925	focal adhesion
0.34	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.34

GO:0008378

tr|T1EE40|T1EE40_HELRO
Uncharacterized protein
Search

SPHK1

0.68	LOW QUALITY PROTEIN: sphingosine kinase 1

0.57	GO:0016310	phosphorylation
0.39	GO:0046512	sphingosine biosynthetic process
0.38	GO:0003376	sphingosine-1-phosphate signaling pathway
0.37	GO:0001568	blood vessel development
0.37	GO:0007420	brain development
0.37	GO:0008284	positive regulation of cell proliferation
0.37	GO:0042346	positive regulation of NF-kappaB import into nucleus
0.37	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
0.37	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway
0.37	GO:0045987	positive regulation of smooth muscle contraction

0.75	GO:0003951	NAD+ kinase activity
0.39	GO:0017050	D-erythro-sphingosine kinase activity
0.38	GO:0038036	sphingosine-1-phosphate receptor activity
0.38	GO:0008481	sphinganine kinase activity
0.36	GO:0051721	protein phosphatase 2A binding
0.36	GO:0005516	calmodulin binding
0.34	GO:0000287	magnesium ion binding
0.33	GO:0003677	DNA binding
0.33	GO:0046982	protein heterodimerization activity
0.33	GO:0032559	adenyl ribonucleotide binding

0.36	GO:0005829	cytosol
0.36	GO:0097539	ciliary transition fiber
0.33	GO:0000786	nucleosome
0.33	GO:0043227	membrane-bounded organelle
0.33	GO:0005886	plasma membrane

0.75	EC:2.7.1.23	GO:0003951
0.75	KEGG:R00104	GO:0003951

tr|T1EE41|T1EE41_HELRO
Uncharacterized protein
Search

DDX23

0.84	DEAD box ATP-dependent RNA helicase

0.45	GO:0010501	RNA secondary structure unwinding
0.43	GO:0000375	RNA splicing, via transesterification reactions
0.35	GO:1901385	regulation of voltage-gated calcium channel activity
0.34	GO:0006397	mRNA processing
0.34	GO:0007528	neuromuscular junction development
0.34	GO:0050688	regulation of defense response to virus
0.34	GO:0007268	chemical synaptic transmission
0.34	GO:0070588	calcium ion transmembrane transport
0.34	GO:0007264	small GTPase mediated signal transduction
0.34	GO:0022618	ribonucleoprotein complex assembly

0.60	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.43	GO:0008186	RNA-dependent ATPase activity
0.39	GO:0140098	catalytic activity, acting on RNA
0.35	GO:0008331	high voltage-gated calcium channel activity
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding

0.53	GO:0005682	U5 snRNP
0.52	GO:0071013	catalytic step 2 spliceosome
0.48	GO:0005730	nucleolus
0.37	GO:0070062	extracellular exosome
0.36	GO:0005737	cytoplasm
0.34	GO:0005891	voltage-gated calcium channel complex
0.34	GO:0046540	U4/U6 x U5 tri-snRNP complex
0.33	GO:0005654	nucleoplasm
0.33	GO:0005694	chromosome

tr|T1EE42|T1EE42_HELRO
5'-nucleotidase
Search

NT5C3B

0.47	7-methylguanosine phosphate-specific 5'-nucleotidase A

0.68	GO:0016311	dephosphorylation
0.57	GO:0009117	nucleotide metabolic process
0.35	GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

0.79	GO:0008253	5'-nucleotidase activity
0.64	GO:0000287	magnesium ion binding
0.51	GO:0000166	nucleotide binding
0.33	GO:0005515	protein binding

0.49	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:3.1.3.5

GO:0008253

tr|T1EE43|T1EE43_HELRO
Uncharacterized protein
Search

GLYR1

0.80	Glyoxylate reductase 1 homolog

0.52	GO:0055114	oxidation-reduction process
0.34	GO:0006979	response to oxidative stress

0.75	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
0.66	GO:0051287	NAD binding
0.37	GO:0008679	2-hydroxy-3-oxopropionate reductase activity
0.36	GO:0140034	methylation-dependent protein binding
0.36	GO:0042393	histone binding
0.35	GO:0003858	3-hydroxybutyrate dehydrogenase activity

0.34	GO:0005829	cytosol
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.75	EC:1.1.1.44	GO:0004616
0.35	KEGG:R01361	GO:0003858

tr|T1EE44|T1EE44_HELRO
Uncharacterized protein
Search

0.63	Wee1-like CDK tyrosine kinase (Fragment)

0.73	GO:0018108	peptidyl-tyrosine phosphorylation
0.71	GO:0000278	mitotic cell cycle
0.51	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
0.48	GO:1900194	negative regulation of oocyte maturation
0.48	GO:0035038	female pronucleus assembly
0.47	GO:0007143	female meiotic nuclear division
0.47	GO:0060631	regulation of meiosis I
0.44	GO:0000226	microtubule cytoskeleton organization
0.43	GO:0051642	centrosome localization
0.41	GO:0045930	negative regulation of mitotic cell cycle

0.77	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.62	GO:0000287	magnesium ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0005515	protein binding
0.33	GO:0003697	single-stranded DNA binding

0.59	GO:0005634	nucleus
0.44	GO:0031974	membrane-enclosed lumen
0.42	GO:0005829	cytosol
0.40	GO:0044446	intracellular organelle part
0.37	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016020	membrane

0.77

EC:2.7.10.2

GO:0004715

tr|T1EE45|T1EE45_HELRO
Uncharacterized protein
Search

tr|T1EE46|T1EE46_HELRO
Uncharacterized protein
Search

ESRRA

0.82	Estrogen receptor

0.78	GO:0043401	steroid hormone mediated signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.44	GO:0051254	positive regulation of RNA metabolic process
0.43	GO:0010557	positive regulation of macromolecule biosynthetic process
0.43	GO:0031328	positive regulation of cellular biosynthetic process
0.43	GO:0051253	negative regulation of RNA metabolic process
0.43	GO:0010558	negative regulation of macromolecule biosynthetic process

0.79	GO:0003707	steroid hormone receptor activity
0.78	GO:0005496	steroid binding
0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.46	GO:0019904	protein domain specific binding
0.45	GO:0001012	RNA polymerase II regulatory region DNA binding
0.43	GO:0003690	double-stranded DNA binding
0.32	GO:0016491	oxidoreductase activity

0.61	GO:0005634	nucleus
0.49	GO:0045171	intercellular bridge
0.44	GO:0015630	microtubule cytoskeleton
0.43	GO:0043233	organelle lumen
0.40	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.32

GO:0016491

tr|T1EE47|T1EE47_HELRO
Uncharacterized protein
Search

NUDC

0.81	Nuclear migration protein nudC (inferred by orthology to a human protein)

0.62	GO:0032502	developmental process
0.57	GO:0051647	nucleus localization
0.56	GO:0032501	multicellular organismal process
0.55	GO:0006457	protein folding
0.53	GO:0051932	synaptic transmission, GABAergic
0.52	GO:0060271	cilium assembly
0.50	GO:0007338	single fertilization
0.50	GO:0048489	synaptic vesicle transport
0.47	GO:1900006	positive regulation of dendrite development
0.47	GO:0010770	positive regulation of cell morphogenesis involved in differentiation

0.56	GO:0051082	unfolded protein binding
0.55	GO:0045296	cadherin binding
0.46	GO:0042802	identical protein binding
0.39	GO:0004176	ATP-dependent peptidase activity
0.37	GO:0004252	serine-type endopeptidase activity
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding

0.50	GO:0005829	cytosol
0.47	GO:0045202	synapse
0.30	GO:0031224	intrinsic component of membrane

0.37

GO:0004252

tr|T1EE48|T1EE48_HELRO
Uncharacterized protein
Search

IMPACT

0.95	Imprinted and ancient gene protein-like protein (Fragment)

0.84	GO:0060733	regulation of eIF2 alpha phosphorylation by amino acid starvation
0.76	GO:0031333	negative regulation of protein complex assembly
0.74	GO:1901561	response to benomyl
0.74	GO:0071494	cellular response to UV-C
0.73	GO:1990253	cellular response to leucine starvation
0.72	GO:0071264	positive regulation of translational initiation in response to starvation
0.72	GO:0031953	negative regulation of protein autophosphorylation
0.72	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress
0.71	GO:0071468	cellular response to acidic pH
0.69	GO:0070301	cellular response to hydrogen peroxide

0.69	GO:0043022	ribosome binding
0.69	GO:0003779	actin binding
0.62	GO:0004860	protein kinase inhibitor activity
0.44	GO:0004969	histamine receptor activity
0.35	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.34	GO:0008270	zinc ion binding

0.78	GO:0005844	polysome
0.50	GO:0005840	ribosome
0.35	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EE49|T1EE49_HELRO
Uncharacterized protein
Search

0.38	GO:0045087	innate immune response
0.37	GO:0097588	archaeal or bacterial-type flagellum-dependent cell motility
0.37	GO:0016539	intein-mediated protein splicing
0.37	GO:0006364	rRNA processing
0.36	GO:0065007	biological regulation
0.35	GO:0042274	ribosomal small subunit biogenesis
0.35	GO:0023052	signaling
0.35	GO:0007154	cell communication
0.34	GO:0051716	cellular response to stimulus
0.34	GO:0006351	transcription, DNA-templated

0.55	GO:0016757	transferase activity, transferring glycosyl groups
0.38	GO:0008146	sulfotransferase activity
0.37	GO:0046983	protein dimerization activity
0.36	GO:0043565	sequence-specific DNA binding
0.36	GO:0001012	RNA polymerase II regulatory region DNA binding
0.36	GO:0030515	snoRNA binding
0.36	GO:0004252	serine-type endopeptidase activity
0.36	GO:0003690	double-stranded DNA binding
0.34	GO:0003700	DNA binding transcription factor activity
0.34	GO:0022857	transmembrane transporter activity

0.39	GO:0005634	nucleus
0.37	GO:0043232	intracellular non-membrane-bounded organelle
0.36	GO:0030686	90S preribosome
0.36	GO:0032040	small-subunit processome
0.35	GO:0043233	organelle lumen
0.34	GO:0005737	cytoplasm
0.34	GO:0043234	protein complex
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.55

GO:0016757

tr|T1EE50|T1EE50_HELRO
Uncharacterized protein
Search

DHTKD1

0.95	Dehydrogenase E1 and transketolase domain containing 1

0.68	GO:0006099	tricarboxylic acid cycle
0.55	GO:0002244	hematopoietic progenitor cell differentiation
0.39	GO:0006757	ATP generation from ADP
0.39	GO:0006090	pyruvate metabolic process
0.38	GO:0016052	carbohydrate catabolic process
0.38	GO:0019362	pyridine nucleotide metabolic process
0.33	GO:0015031	protein transport

0.77	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity
0.70	GO:0030976	thiamine pyrophosphate binding

0.48	GO:0045252	oxoglutarate dehydrogenase complex
0.46	GO:0005739	mitochondrion
0.44	GO:0005829	cytosol
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

0.77

EC:1.2.4.2

GO:0004591

tr|T1EE51|T1EE51_HELRO
Uncharacterized protein
Search

PRKAB2

0.85	AMP-activated protein kinase beta subunit

0.52	GO:0016310	phosphorylation
0.44	GO:0010581	regulation of starch biosynthetic process
0.43	GO:0035090	maintenance of apical/basal cell polarity
0.43	GO:0070050	neuron cellular homeostasis
0.43	GO:0036211	protein modification process
0.42	GO:0019252	starch biosynthetic process
0.41	GO:0044267	cellular protein metabolic process
0.40	GO:0035878	nail development
0.38	GO:0010628	positive regulation of gene expression
0.36	GO:0006633	fatty acid biosynthetic process

0.55	GO:0016301	kinase activity
0.46	GO:0042802	identical protein binding
0.43	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.43	GO:0060089	molecular transducer activity
0.42	GO:0140096	catalytic activity, acting on a protein
0.41	GO:2001070	starch binding
0.34	GO:0019901	protein kinase binding
0.34	GO:0004623	phospholipase A2 activity
0.33	GO:0005509	calcium ion binding

0.52	GO:0031588	nucleotide-activated protein kinase complex
0.43	GO:0009569	chloroplast starch grain
0.40	GO:0009570	chloroplast stroma
0.37	GO:0005634	nucleus
0.35	GO:0043233	organelle lumen
0.34	GO:0005829	cytosol
0.34	GO:0005952	cAMP-dependent protein kinase complex
0.34	GO:0016324	apical plasma membrane
0.33	GO:0005576	extracellular region

0.43

GO:0016773

tr|T1EE52|T1EE52_HELRO
Uncharacterized protein
Search

SLC26A11

0.78	Sodium-independent sulfate anion transporter

0.75	GO:1902358	sulfate transmembrane transport
0.49	GO:0015701	bicarbonate transport
0.49	GO:0019532	oxalate transport
0.48	GO:0051453	regulation of intracellular pH
0.46	GO:0042391	regulation of membrane potential
0.46	GO:1902476	chloride transmembrane transport
0.33	GO:0000413	protein peptidyl-prolyl isomerization

0.78	GO:0008271	secondary active sulfate transmembrane transporter activity
0.49	GO:0015106	bicarbonate transmembrane transporter activity
0.49	GO:0019531	oxalate transmembrane transporter activity
0.48	GO:0015301	anion:anion antiporter activity
0.46	GO:0005254	chloride channel activity
0.33	GO:0003755	peptidyl-prolyl cis-trans isomerase activity

0.47	GO:0005765	lysosomal membrane
0.43	GO:0005794	Golgi apparatus
0.43	GO:0005783	endoplasmic reticulum
0.43	GO:0005654	nucleoplasm
0.42	GO:0005887	integral component of plasma membrane
0.36	GO:0070062	extracellular exosome
0.34	GO:0009507	chloroplast

0.33

GO:0003755

tr|T1EE53|T1EE53_HELRO
Receptor expression-enhancing protein
Search

0.70	Receptor expression-enhancing protein (Fragment)

0.45	GO:0050908	detection of light stimulus involved in visual perception
0.43	GO:0032386	regulation of intracellular transport

0.33	GO:0005515	protein binding
0.33	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

0.47	GO:0044317	rod spherule
0.44	GO:0001917	photoreceptor inner segment
0.43	GO:0098827	endoplasmic reticulum subcompartment
0.43	GO:0045177	apical part of cell
0.41	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.33	GO:0005634	nucleus
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:2.3.1

GO:0016747

tr|T1EE54|T1EE54_HELRO
Uncharacterized protein
Search

CAM

0.39	Calmodulin

0.35	GO:0019722	calcium-mediated signaling
0.34	GO:2000082	regulation of L-ascorbic acid biosynthetic process
0.34	GO:0005513	detection of calcium ion
0.34	GO:0010099	regulation of photomorphogenesis
0.33	GO:0034599	cellular response to oxidative stress

0.70	GO:0005509	calcium ion binding
0.35	GO:0005515	protein binding

0.36	GO:0005773	vacuole
0.35	GO:0005874	microtubule
0.35	GO:0005829	cytosol
0.35	GO:0098805	whole membrane
0.34	GO:0098588	bounding membrane of organelle
0.33	GO:0005929	cilium
0.33	GO:0005886	plasma membrane
0.33	GO:0031410	cytoplasmic vesicle

tr|T1EE55|T1EE55_HELRO
Uncharacterized protein
Search

tr|T1EE56|T1EE56_HELRO
Uncharacterized protein
Search

ARHGAP39

0.58	rho GTPase-activating protein 39

0.61	GO:0007165	signal transduction
0.41	GO:0016199	axon midline choice point recognition
0.40	GO:0043547	positive regulation of GTPase activity
0.35	GO:0051056	regulation of small GTPase mediated signal transduction

0.40

GO:0005096

GTPase activator activity

0.68	GO:0005856	cytoskeleton
0.34	GO:0005737	cytoplasm
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EE57|T1EE57_HELRO
Uncharacterized protein
Search

TMEM129

0.93	Transmembrane protein 129

0.73	GO:0016567	protein ubiquitination
0.59	GO:1903513	endoplasmic reticulum to cytosol transport
0.59	GO:0032527	protein exit from endoplasmic reticulum
0.57	GO:0030433	ubiquitin-dependent ERAD pathway

0.76

GO:0061630

ubiquitin protein ligase activity

0.51	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane

tr|T1EE58|T1EE58_HELRO
Uncharacterized protein
Search

tr|T1EE59|T1EE59_HELRO
Uncharacterized protein
Search

GMPPB

0.46	GDP-mannose pyrophosphorylase B

0.49	GO:0009058	biosynthetic process
0.45	GO:0019673	GDP-mannose metabolic process
0.38	GO:0035167	larval lymph gland hemopoiesis
0.35	GO:0043413	macromolecule glycosylation
0.35	GO:0009100	glycoprotein metabolic process
0.34	GO:0048747	muscle fiber development
0.34	GO:0009272	fungal-type cell wall biogenesis
0.34	GO:0043647	inositol phosphate metabolic process
0.33	GO:0036211	protein modification process
0.33	GO:0044036	cell wall macromolecule metabolic process

0.63	GO:0016779	nucleotidyltransferase activity
0.38	GO:0032550	purine ribonucleoside binding
0.37	GO:0019001	guanyl nucleotide binding
0.35	GO:0032555	purine ribonucleotide binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding
0.32	GO:0016301	kinase activity

0.38	GO:0005739	mitochondrion
0.36	GO:0070062	extracellular exosome
0.34	GO:0051286	cell tip
0.30	GO:0016020	membrane

0.63

GO:0016779

tr|T1EE60|T1EE60_HELRO
Adenylyltransferase and sulfurtransferase MOCS3
Search

MOCS3

0.74	Adenylyltransferase and sulfurtransferase MOCS3

0.80	GO:0098822	peptidyl-cysteine modification to L-cysteine persulfide
0.79	GO:0002143	tRNA wobble position uridine thiolation
0.75	GO:0018307	enzyme active site formation
0.67	GO:0006777	Mo-molybdopterin cofactor biosynthetic process
0.52	GO:0032447	protein urmylation
0.42	GO:2000220	regulation of pseudohyphal growth
0.42	GO:0018117	protein adenylylation
0.42	GO:0001403	invasive growth in response to glucose limitation
0.41	GO:0007114	cell budding
0.39	GO:0034599	cellular response to oxidative stress

0.81	GO:0061604	molybdopterin-synthase sulfurtransferase activity
0.79	GO:0061605	molybdopterin-synthase adenylyltransferase activity
0.76	GO:0004792	thiosulfate sulfurtransferase activity
0.74	GO:0008641	ubiquitin-like modifier activating enzyme activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0046872	metal ion binding
0.42	GO:0070733	protein adenylyltransferase activity
0.39	GO:0042802	identical protein binding

0.66	GO:0005829	cytosol
0.41	GO:0019008	molybdopterin synthase complex
0.33	GO:0043231	intracellular membrane-bounded organelle
0.33	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.81	EC:2.8.1.11	GO:0061604
0.76	KEGG:R01931	GO:0004792

tr|T1EE61|T1EE61_HELRO
Uncharacterized protein
Search

0.11	Neuronal cell adhesion molecule

0.36	GO:0090497	mesenchymal cell migration
0.36	GO:0035122	embryonic medial fin morphogenesis
0.36	GO:0043589	skin morphogenesis
0.35	GO:0019221	cytokine-mediated signaling pathway
0.35	GO:0030198	extracellular matrix organization
0.34	GO:0065009	regulation of molecular function
0.34	GO:0035023	regulation of Rho protein signal transduction
0.34	GO:0045861	negative regulation of proteolysis
0.33	GO:0006468	protein phosphorylation
0.33	GO:0006508	proteolysis

0.36	GO:0004896	cytokine receptor activity
0.35	GO:0005509	calcium ion binding
0.34	GO:0098772	molecular function regulator
0.34	GO:0017048	Rho GTPase binding
0.33	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.33	GO:0016301	kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.33	GO:0005576	extracellular region
0.30	GO:0016020	membrane

0.33

GO:0016773

tr|T1EE62|T1EE62_HELRO
Uncharacterized protein
Search

tr|T1EE63|T1EE63_HELRO
Sodium/hydrogen exchanger
Search

SLC9A3

0.63	Sodium/hydrogen exchanger

0.79	GO:0006885	regulation of pH
0.77	GO:0035725	sodium ion transmembrane transport
0.63	GO:1902600	hydrogen ion transmembrane transport
0.53	GO:0099587	inorganic ion import across plasma membrane
0.47	GO:0030004	cellular monovalent inorganic cation homeostasis
0.44	GO:0071805	potassium ion transmembrane transport
0.35	GO:0001745	compound eye morphogenesis
0.35	GO:0051384	response to glucocorticoid
0.35	GO:0002028	regulation of sodium ion transport
0.35	GO:0007623	circadian rhythm

0.82	GO:0015385	sodium:proton antiporter activity
0.51	GO:0030165	PDZ domain binding
0.48	GO:0015386	potassium:proton antiporter activity

0.51	GO:0031526	brush border membrane
0.49	GO:0016324	apical plasma membrane
0.49	GO:0070062	extracellular exosome
0.35	GO:0009986	cell surface
0.30	GO:0016021	integral component of membrane

tr|T1EE64|T1EE64_HELRO
Uncharacterized protein
Search

DYNC1H1

0.85	Dynein cytoplasmic 1 heavy chain 1

0.74	GO:0007018	microtubule-based movement
0.53	GO:1905832	positive regulation of spindle assembly
0.52	GO:0090235	regulation of metaphase plate congression
0.51	GO:0034063	stress granule assembly
0.51	GO:0033962	cytoplasmic mRNA processing body assembly
0.50	GO:0051656	establishment of organelle localization
0.50	GO:0051653	spindle localization
0.50	GO:0060236	regulation of mitotic spindle organization
0.50	GO:0000226	microtubule cytoskeleton organization
0.49	GO:0032388	positive regulation of intracellular transport

0.75	GO:0003777	microtubule motor activity
0.61	GO:0016887	ATPase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0051959	dynein light intermediate chain binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0045503	dynein light chain binding
0.48	GO:0045505	dynein intermediate chain binding
0.33	GO:0003723	RNA binding

0.78	GO:0030286	dynein complex
0.50	GO:0030175	filopodium
0.48	GO:0005813	centrosome
0.46	GO:0005874	microtubule
0.37	GO:0005737	cytoplasm
0.36	GO:0031012	extracellular matrix
0.36	GO:0070062	extracellular exosome
0.36	GO:0030424	axon
0.35	GO:0012505	endomembrane system
0.35	GO:0002177	manchette

0.61

GO:0016887

tr|T1EE65|T1EE65_HELRO
Uncharacterized protein
Search

0.57	Junctophilin 2

0.50	GO:0051924	regulation of calcium ion transport
0.50	GO:0050885	neuromuscular process controlling balance
0.49	GO:0007612	learning
0.49	GO:0048167	regulation of synaptic plasticity
0.47	GO:0001817	regulation of cytokine production
0.42	GO:0051050	positive regulation of transport
0.42	GO:0050848	regulation of calcium-mediated signaling
0.41	GO:2001257	regulation of cation channel activity
0.41	GO:0060402	calcium ion transport into cytosol
0.41	GO:0051282	regulation of sequestering of calcium ion

0.41	GO:0015278	calcium-release channel activity
0.40	GO:0010314	phosphatidylinositol-5-phosphate binding
0.40	GO:0070300	phosphatidic acid binding
0.40	GO:0001786	phosphatidylserine binding
0.40	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.40	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding
0.40	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.39	GO:0070273	phosphatidylinositol-4-phosphate binding
0.39	GO:0032266	phosphatidylinositol-3-phosphate binding
0.34	GO:0005515	protein binding

0.68	GO:0030314	junctional membrane complex
0.50	GO:0005790	smooth endoplasmic reticulum
0.49	GO:0043198	dendritic shaft
0.41	GO:0016529	sarcoplasmic reticulum
0.39	GO:0030018	Z disc
0.39	GO:0005789	endoplasmic reticulum membrane
0.36	GO:0098588	bounding membrane of organelle
0.35	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1EE66|T1EE66_HELRO
Uncharacterized protein
Search

RAB5A

0.75	Putative rab subfamily protein of small gtpase

0.52	GO:0060627	regulation of vesicle-mediated transport
0.50	GO:0099504	synaptic vesicle cycle
0.50	GO:0051489	regulation of filopodium assembly
0.49	GO:0032386	regulation of intracellular transport
0.49	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway
0.48	GO:0016197	endosomal transport
0.48	GO:0051050	positive regulation of transport
0.48	GO:0051036	regulation of endosome size
0.48	GO:0045056	transcytosis
0.47	GO:0098927	vesicle-mediated transport between endosomal compartments

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.48	GO:0019003	GDP binding
0.36	GO:0030742	GTP-dependent protein binding

0.53	GO:0005769	early endosome
0.51	GO:0030139	endocytic vesicle
0.49	GO:0098793	presynapse
0.49	GO:0001726	ruffle
0.48	GO:0010009	cytoplasmic side of endosome membrane
0.47	GO:0098857	membrane microdomain
0.46	GO:0044306	neuron projection terminus
0.46	GO:0033267	axon part
0.45	GO:0036477	somatodendritic compartment
0.45	GO:0015629	actin cytoskeleton

tr|T1EE67|T1EE67_HELRO
Uncharacterized protein
Search

0.39	Zinc carboxypeptidase

0.61	GO:0006508	proteolysis
0.37	GO:0000272	polysaccharide catabolic process
0.35	GO:0009405	pathogenesis
0.34	GO:0006357	regulation of transcription by RNA polymerase II
0.34	GO:0071555	cell wall organization
0.33	GO:0044257	cellular protein catabolic process
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:0007186	G-protein coupled receptor signaling pathway

0.78	GO:0004181	metallocarboxypeptidase activity
0.63	GO:0008270	zinc ion binding
0.34	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.34	GO:0070003	threonine-type peptidase activity
0.33	GO:0004930	G-protein coupled receptor activity
0.33	GO:0004175	endopeptidase activity
0.33	GO:0003677	DNA binding

0.37	GO:0005576	extracellular region
0.34	GO:0005773	vacuole
0.34	GO:0046658	anchored component of plasma membrane
0.34	GO:0005634	nucleus
0.34	GO:0005839	proteasome core complex
0.30	GO:0016021	integral component of membrane

0.78

GO:0004181

tr|T1EE68|T1EE68_HELRO
Uncharacterized protein
Search

0.39	Zinc carboxypeptidase

0.61	GO:0006508	proteolysis
0.45	GO:0042730	fibrinolysis
0.44	GO:0002002	regulation of angiotensin levels in blood
0.36	GO:0000272	polysaccharide catabolic process
0.35	GO:2000346	negative regulation of hepatocyte proliferation
0.35	GO:0003331	positive regulation of extracellular matrix constituent secretion
0.35	GO:0010757	negative regulation of plasminogen activation
0.35	GO:0051918	negative regulation of fibrinolysis
0.35	GO:0097421	liver regeneration
0.35	GO:0071333	cellular response to glucose stimulus

0.78	GO:0004181	metallocarboxypeptidase activity
0.63	GO:0008270	zinc ion binding
0.34	GO:0008378	galactosyltransferase activity
0.34	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.33	GO:0070003	threonine-type peptidase activity
0.33	GO:0030246	carbohydrate binding
0.33	GO:0005254	chloride channel activity
0.32	GO:0004175	endopeptidase activity
0.32	GO:0003779	actin binding
0.32	GO:0003677	DNA binding

0.44	GO:0044421	extracellular region part
0.34	GO:0031982	vesicle
0.33	GO:0005634	nucleus
0.33	GO:0005839	proteasome core complex
0.33	GO:0034707	chloride channel complex
0.33	GO:0012505	endomembrane system
0.32	GO:0044444	cytoplasmic part
0.32	GO:0005886	plasma membrane

0.78

GO:0004181

tr|T1EE69|T1EE69_HELRO
Uncharacterized protein
Search

0.40	Zinc carboxypeptidase

0.61	GO:0006508	proteolysis
0.36	GO:0000272	polysaccharide catabolic process
0.35	GO:0042730	fibrinolysis
0.33	GO:0044257	cellular protein catabolic process

0.78	GO:0004181	metallocarboxypeptidase activity
0.63	GO:0008270	zinc ion binding
0.34	GO:0070003	threonine-type peptidase activity
0.33	GO:0030246	carbohydrate binding
0.33	GO:0004175	endopeptidase activity

0.37	GO:0005615	extracellular space
0.34	GO:0005839	proteasome core complex
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.78

GO:0004181

tr|T1EE70|T1EE70_HELRO
Uncharacterized protein
Search

0.63	Spermatogenesis associated factor

0.35	GO:0051301	cell division
0.35	GO:0042273	ribosomal large subunit biogenesis
0.35	GO:0000226	microtubule cytoskeleton organization
0.34	GO:0042493	response to drug
0.34	GO:1990171	SCF complex disassembly in response to cadmium stress
0.34	GO:0061166	establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site
0.34	GO:0016320	endoplasmic reticulum membrane fusion
0.34	GO:2001168	positive regulation of histone H2B ubiquitination
0.34	GO:0051306	mitotic sister chromatid separation
0.34	GO:0034517	ribophagy

0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0016787	hydrolase activity
0.36	GO:0005516	calmodulin binding
0.34	GO:0019904	protein domain specific binding
0.33	GO:0043130	ubiquitin binding
0.33	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0019888	protein phosphatase regulator activity

0.35	GO:0031984	organelle subcompartment
0.35	GO:0030687	preribosome, large subunit precursor
0.35	GO:0044434	chloroplast part
0.35	GO:0042651	thylakoid membrane
0.34	GO:0036266	Cdc48p-Npl4p-Vms1p AAA ATPase complex
0.34	GO:1990112	RQC complex
0.34	GO:1990023	mitotic spindle midzone
0.34	GO:0000153	cytoplasmic ubiquitin ligase complex
0.33	GO:0022625	cytosolic large ribosomal subunit
0.33	GO:0000790	nuclear chromatin

0.37

GO:0016787

tr|T1EE71|T1EE71_HELRO
Uncharacterized protein
Search

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.70	GO:0007420	brain development
0.49	GO:0001841	neural tube formation
0.47	GO:0009887	animal organ morphogenesis
0.47	GO:0007601	visual perception
0.40	GO:0007267	cell-cell signaling
0.37	GO:0007416	synapse assembly
0.37	GO:0007423	sensory organ development
0.37	GO:0030182	neuron differentiation
0.35	GO:0044331	cell-cell adhesion mediated by cadherin

0.70	GO:0005509	calcium ion binding
0.46	GO:0042803	protein homodimerization activity
0.34	GO:0004930	G-protein coupled receptor activity

0.56	GO:0005886	plasma membrane
0.35	GO:0032420	stereocilium
0.34	GO:0005913	cell-cell adherens junction
0.30	GO:0016021	integral component of membrane

tr|T1EE72|T1EE72_HELRO
Uncharacterized protein
Search

UTP15

0.82	Rho guanine nucleotide exchange factor 28

0.66	GO:0006364	rRNA processing
0.49	GO:2000234	positive regulation of rRNA processing
0.49	GO:0045943	positive regulation of transcription by RNA polymerase I
0.42	GO:0045766	positive regulation of angiogenesis
0.35	GO:0042274	ribosomal small subunit biogenesis
0.34	GO:0035023	regulation of Rho protein signal transduction
0.34	GO:0016310	phosphorylation
0.34	GO:0006012	galactose metabolic process
0.34	GO:0035206	regulation of hemocyte proliferation
0.34	GO:0009561	megagametogenesis

0.36	GO:0030515	snoRNA binding
0.34	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.34	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.34	GO:0016301	kinase activity
0.34	GO:0005534	galactose binding
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0032555	purine ribonucleotide binding
0.33	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0043168	anion binding
0.33	GO:0008144	drug binding

0.70	GO:0005730	nucleolus
0.43	GO:0005783	endoplasmic reticulum
0.41	GO:0019013	viral nucleocapsid
0.39	GO:0030529	intracellular ribonucleoprotein complex
0.37	GO:0033553	rDNA heterochromatin
0.34	GO:0005654	nucleoplasm
0.34	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0016773

tr|T1EE73|T1EE73_HELRO
Uncharacterized protein
Search

tr|T1EE74|T1EE74_HELRO
Uncharacterized protein
Search

USP46

0.90	Ubiquitin carboxyl-terminal hydrolase 46

0.76	GO:0016579	protein deubiquitination
0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.48	GO:0060013	righting reflex
0.47	GO:0008343	adult feeding behavior
0.47	GO:0001662	behavioral fear response
0.47	GO:0048149	behavioral response to ethanol
0.47	GO:0032228	regulation of synaptic transmission, GABAergic
0.35	GO:0050862	positive regulation of T cell receptor signaling pathway
0.34	GO:0045746	negative regulation of Notch signaling pathway
0.33	GO:0055085	transmembrane transport

0.77	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.38	GO:0004197	cysteine-type endopeptidase activity
0.33	GO:0046872	metal ion binding
0.33	GO:0022857	transmembrane transporter activity

0.33	GO:0005829	cytosol
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.77

GO:0036459

tr|T1EE75|T1EE75_HELRO
AP-3 complex subunit delta
Search

AP3D1

0.72	AP-3 complex subunit delta

0.67	GO:0006886	intracellular protein transport
0.66	GO:0016192	vesicle-mediated transport
0.50	GO:0048499	synaptic vesicle membrane organization
0.49	GO:0035646	endosome to melanosome transport
0.49	GO:0048007	antigen processing and presentation, exogenous lipid antigen via MHC class Ib
0.49	GO:0051138	positive regulation of NK T cell differentiation
0.49	GO:0061088	regulation of sequestering of zinc ion
0.48	GO:0061462	protein localization to lysosome
0.48	GO:0008089	anterograde axonal transport
0.47	GO:0047496	vesicle transport along microtubule

0.33	GO:0005515	protein binding
0.32	GO:0005215	transporter activity

0.80	GO:0030123	AP-3 adaptor complex
0.52	GO:0005794	Golgi apparatus
0.50	GO:0098830	presynaptic endosome
0.47	GO:1904115	axon cytoplasm
0.47	GO:0043195	terminal bouton
0.45	GO:0010008	endosome membrane
0.38	GO:0005886	plasma membrane
0.36	GO:0005765	lysosomal membrane
0.36	GO:0031984	organelle subcompartment
0.35	GO:0005770	late endosome

tr|T1EE76|T1EE76_HELRO
Uncharacterized protein
Search

0.66	GO:0035023	regulation of Rho protein signal transduction
0.57	GO:0065009	regulation of molecular function
0.50	GO:0006897	endocytosis
0.50	GO:0035556	intracellular signal transduction
0.44	GO:0051897	positive regulation of protein kinase B signaling
0.44	GO:0043524	negative regulation of neuron apoptotic process
0.42	GO:0042327	positive regulation of phosphorylation
0.38	GO:1903861	positive regulation of dendrite extension
0.34	GO:0030433	ubiquitin-dependent ERAD pathway
0.34	GO:0036465	synaptic vesicle recycling

0.70	GO:0005509	calcium ion binding
0.66	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.46	GO:0070064	proline-rich region binding
0.44	GO:0032947	protein complex scaffold activity
0.44	GO:0019209	kinase activator activity
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0019001	guanyl nucleotide binding
0.34	GO:0004872	receptor activity
0.34	GO:0031625	ubiquitin protein ligase binding
0.33	GO:0032555	purine ribonucleotide binding

0.44	GO:0005905	clathrin-coated pit
0.44	GO:0030027	lamellipodium
0.43	GO:0030139	endocytic vesicle
0.37	GO:0005886	plasma membrane
0.37	GO:0005813	centrosome
0.35	GO:0043005	neuron projection
0.35	GO:0045202	synapse
0.35	GO:0030054	cell junction
0.34	GO:0005829	cytosol
0.33	GO:0070062	extracellular exosome

0.31

GO:0016787

tr|T1EE77|T1EE77_HELRO
Uncharacterized protein
Search

tr|T1EE78|T1EE78_HELRO
Uncharacterized protein
Search

0.77	GO:0016055	Wnt signaling pathway
0.51	GO:0006357	regulation of transcription by RNA polymerase II
0.41	GO:0002681	somatic recombination of T cell receptor gene segments
0.38	GO:0033151	V(D)J recombination
0.35	GO:1904837	beta-catenin-TCF complex assembly
0.35	GO:0009790	embryo development
0.35	GO:0009888	tissue development
0.34	GO:2000036	regulation of stem cell population maintenance
0.34	GO:0009653	anatomical structure morphogenesis
0.34	GO:0045892	negative regulation of transcription, DNA-templated

0.58	GO:0008013	beta-catenin binding
0.55	GO:0003677	DNA binding
0.42	GO:0001067	regulatory region nucleic acid binding
0.36	GO:0016757	transferase activity, transferring glycosyl groups
0.34	GO:0003700	DNA binding transcription factor activity
0.34	GO:0003682	chromatin binding

0.61	GO:0005634	nucleus
0.42	GO:0005667	transcription factor complex
0.41	GO:0005829	cytosol
0.41	GO:0031974	membrane-enclosed lumen
0.38	GO:0044446	intracellular organelle part
0.33	GO:0005694	chromosome
0.30	GO:0031224	intrinsic component of membrane

0.36

GO:0016757

tr|T1EE79|T1EE79_HELRO
Uncharacterized protein
Search

0.72	Mixed-lineage leukemia protein, mll, putative

0.83	GO:0051568	histone H3-K4 methylation
0.53	GO:1902036	regulation of hematopoietic stem cell differentiation
0.49	GO:1902275	regulation of chromatin organization
0.43	GO:0018027	peptidyl-lysine dimethylation
0.42	GO:0046427	positive regulation of JAK-STAT cascade
0.42	GO:0018023	peptidyl-lysine trimethylation
0.40	GO:2000648	positive regulation of stem cell proliferation
0.40	GO:2000179	positive regulation of neural precursor cell proliferation
0.40	GO:0019827	stem cell population maintenance
0.38	GO:0045637	regulation of myeloid cell differentiation

0.83	GO:0042800	histone methyltransferase activity (H3-K4 specific)
0.55	GO:0003723	RNA binding
0.50	GO:0008013	beta-catenin binding
0.46	GO:0008134	transcription factor binding
0.38	GO:1990188	euchromatin binding
0.33	GO:0004814	arginine-tRNA ligase activity
0.33	GO:0008270	zinc ion binding
0.32	GO:0003677	DNA binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding

0.71	GO:0048188	Set1C/COMPASS complex
0.49	GO:0016607	nuclear speck
0.48	GO:0000785	chromatin
0.46	GO:0044454	nuclear chromosome part
0.42	GO:0005700	polytene chromosome
0.31	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:6.1.1.19

GO:0004814

tr|T1EE80|T1EE80_HELRO
Uncharacterized protein
Search

0.94	Sodium bicarbonate transporter protein 11

0.69	GO:0015698	inorganic anion transport
0.46	GO:0035725	sodium ion transmembrane transport
0.45	GO:0015701	bicarbonate transport
0.45	GO:0030003	cellular cation homeostasis
0.44	GO:0042044	fluid transport
0.44	GO:0006855	drug transmembrane transport
0.44	GO:0098656	anion transmembrane transport
0.43	GO:0006885	regulation of pH
0.39	GO:1902600	hydrogen ion transmembrane transport
0.33	GO:0006526	arginine biosynthetic process

0.83	GO:0005452	inorganic anion exchanger activity
0.47	GO:0046715	active borate transmembrane transporter activity
0.46	GO:0015106	bicarbonate transmembrane transporter activity
0.46	GO:0015252	proton channel activity
0.44	GO:0005272	sodium channel activity
0.40	GO:0046983	protein dimerization activity
0.36	GO:0015301	anion:anion antiporter activity
0.35	GO:0015293	symporter activity
0.33	GO:0004055	argininosuccinate synthase activity
0.32	GO:0016757	transferase activity, transferring glycosyl groups

0.40	GO:0005887	integral component of plasma membrane
0.34	GO:0016323	basolateral plasma membrane

0.33

EC:6.3.4.5

GO:0004055

tr|T1EE81|T1EE81_HELRO
Uncharacterized protein
Search

0.86	Peroxisome proliferator activated receptor interacting complex protein

0.78	GO:0033674	positive regulation of kinase activity
0.76	GO:0045859	regulation of protein kinase activity
0.72	GO:0006417	regulation of translation
0.64	GO:0033554	cellular response to stress
0.39	GO:0042594	response to starvation
0.39	GO:0031669	cellular response to nutrient levels
0.38	GO:0045944	positive regulation of transcription by RNA polymerase II
0.36	GO:0043248	proteasome assembly
0.35	GO:0016925	protein sumoylation
0.34	GO:0016310	phosphorylation

0.79	GO:0019887	protein kinase regulator activity
0.78	GO:0019901	protein kinase binding
0.74	GO:0043022	ribosome binding
0.39	GO:0045296	cadherin binding
0.36	GO:0032947	protein complex scaffold activity
0.35	GO:0016301	kinase activity
0.33	GO:0003723	RNA binding

0.39	GO:0005844	polysome
0.37	GO:0005829	cytosol
0.34	GO:0005921	gap junction
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

tr|T1EE82|T1EE82_HELRO
Uncharacterized protein
Search

0.11	Laminin subunit beta-1

0.55	GO:0035295	tube development
0.53	GO:0048731	system development
0.52	GO:0034446	substrate adhesion-dependent cell spreading
0.52	GO:0040017	positive regulation of locomotion
0.51	GO:0070831	basement membrane assembly
0.50	GO:0033627	cell adhesion mediated by integrin
0.49	GO:0048598	embryonic morphogenesis
0.48	GO:0016477	cell migration
0.48	GO:0009888	tissue development
0.48	GO:0055002	striated muscle cell development

0.40	GO:0005201	extracellular matrix structural constituent
0.38	GO:0003676	nucleic acid binding
0.34	GO:0005509	calcium ion binding

0.58	GO:0005604	basement membrane
0.38	GO:0005615	extracellular space
0.36	GO:0043234	protein complex
0.30	GO:0016020	membrane

tr|T1EE83|T1EE83_HELRO
Uncharacterized protein
Search

SBNO1

0.90	Nuclear helicase mop 3/sno dead box superfamily

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.34	GO:0048190	wing disc dorsal/ventral pattern formation
0.34	GO:0008587	imaginal disc-derived wing margin morphogenesis
0.34	GO:0007219	Notch signaling pathway
0.33	GO:1902680	positive regulation of RNA biosynthetic process
0.33	GO:0050727	regulation of inflammatory response

0.43	GO:0004386	helicase activity
0.32	GO:0003677	DNA binding

0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EE84|T1EE84_HELRO
O-phosphoseryl-tRNA(Sec) selenium transferase
Search

SEPSECS

0.84	O-phosphoseryl-tRNA(Sec) selenium transferase

0.78	GO:0097056	selenocysteinyl-tRNA(Sec) biosynthetic process
0.55	GO:0043043	peptide biosynthetic process
0.51	GO:0044267	cellular protein metabolic process
0.50	GO:0010467	gene expression
0.49	GO:0034645	cellular macromolecule biosynthetic process
0.41	GO:0006417	regulation of translation

0.80	GO:0016785	transferase activity, transferring selenium-containing groups
0.65	GO:0000049	tRNA binding
0.34	GO:0042802	identical protein binding

0.45	GO:0005737	cytoplasm
0.38	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.80

EC:2.9 EC:2.9.1

GO:0016785

tr|T1EE85|T1EE85_HELRO
Uncharacterized protein
Search

0.53	Dopey family member 1

0.80	GO:0006895	Golgi to endosome transport
0.37	GO:0055114	oxidation-reduction process

0.41	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.40	GO:0020037	heme binding
0.39	GO:0005506	iron ion binding

0.74	GO:0005802	trans-Golgi network
0.71	GO:0005768	endosome
0.64	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.41

GO:0016705

tr|T1EE86|T1EE86_HELRO
Uncharacterized protein
Search

0.54	GO:1903146	regulation of autophagy of mitochondrion
0.53	GO:0003062	regulation of heart rate by chemical signal
0.53	GO:0045542	positive regulation of cholesterol biosynthetic process
0.53	GO:0010867	positive regulation of triglyceride biosynthetic process
0.52	GO:0031065	positive regulation of histone deacetylation
0.51	GO:0042789	mRNA transcription by RNA polymerase II
0.51	GO:0046676	negative regulation of insulin secretion
0.51	GO:0048869	cellular developmental process
0.50	GO:0008286	insulin receptor signaling pathway
0.50	GO:0045944	positive regulation of transcription by RNA polymerase II

0.67	GO:0046983	protein dimerization activity
0.52	GO:0032810	sterol response element binding
0.52	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.48	GO:0004879	nuclear receptor activity
0.47	GO:0019901	protein kinase binding
0.47	GO:0003682	chromatin binding
0.45	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.37	GO:0032403	protein complex binding

0.44	GO:0005634	nucleus
0.44	GO:0005789	endoplasmic reticulum membrane
0.40	GO:0031090	organelle membrane
0.40	GO:0030134	COPII-coated ER to Golgi transport vesicle
0.39	GO:0030133	transport vesicle
0.39	GO:0031967	organelle envelope
0.39	GO:0044433	cytoplasmic vesicle part
0.38	GO:0098791	Golgi subcompartment
0.38	GO:0098805	whole membrane
0.35	GO:0070013	intracellular organelle lumen

tr|T1EE87|T1EE87_HELRO
Uncharacterized protein
Search

0.68	Bone morphogenetic protein 6

0.76	GO:0010469	regulation of receptor activity
0.55	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.55	GO:0060395	SMAD protein signal transduction
0.54	GO:0030509	BMP signaling pathway
0.50	GO:0030501	positive regulation of bone mineralization
0.50	GO:0045669	positive regulation of osteoblast differentiation
0.50	GO:0048468	cell development
0.49	GO:0001822	kidney development
0.49	GO:0048705	skeletal system morphogenesis
0.49	GO:0045666	positive regulation of neuron differentiation

0.78	GO:0008083	growth factor activity
0.54	GO:0070700	BMP receptor binding
0.49	GO:0005160	transforming growth factor beta receptor binding
0.47	GO:0005125	cytokine activity
0.42	GO:0046982	protein heterodimerization activity
0.36	GO:0008201	heparin binding
0.33	GO:0008410	CoA-transferase activity
0.33	GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase activity
0.33	GO:0042803	protein homodimerization activity
0.33	GO:0008017	microtubule binding

0.66	GO:0005576	extracellular region
0.38	GO:0071595	Nem1-Spo7 phosphatase complex
0.36	GO:0031982	vesicle
0.32	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.33	EC:2.8.3	GO:0008410
0.33	KEGG:R06983 KEGG:R07140	GO:0051903

tr|T1EE88|T1EE88_HELRO
Uncharacterized protein
Search

0.44	GO:0070896	positive regulation of transposon integration
0.44	GO:0016348	imaginal disc-derived leg joint morphogenesis
0.43	GO:0018992	germ-line sex determination
0.43	GO:0035017	cuticle pattern formation
0.43	GO:0048067	cuticle pigmentation
0.43	GO:0035316	non-sensory hair organization
0.43	GO:0008343	adult feeding behavior
0.41	GO:0000122	negative regulation of transcription by RNA polymerase II
0.40	GO:0045944	positive regulation of transcription by RNA polymerase II
0.39	GO:0007010	cytoskeleton organization

0.51	GO:0003676	nucleic acid binding
0.36	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.33	GO:0046872	metal ion binding

0.38	GO:0005634	nucleus
0.33	GO:0043233	organelle lumen
0.32	GO:0044446	intracellular organelle part
0.32	GO:0005737	cytoplasm

tr|T1EE89|T1EE89_HELRO
Uncharacterized protein
Search

tr|T1EE90|T1EE90_HELRO
Uncharacterized protein
Search

ARFGAP1

0.91	ADP-ribosylation factor GTPase-activating protein 1

0.76	GO:0043547	positive regulation of GTPase activity
0.44	GO:0030100	regulation of endocytosis
0.42	GO:0032012	regulation of ARF protein signal transduction

0.76	GO:0005096	GTPase activator activity
0.51	GO:0046872	metal ion binding
0.32	GO:0003676	nucleic acid binding

0.44	GO:0014069	postsynaptic density
0.42	GO:0005795	Golgi stack
0.34	GO:0005581	collagen trimer

tr|T1EE91|T1EE91_HELRO
Uncharacterized protein
Search

0.36	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.36	GO:1903506	regulation of nucleic acid-templated transcription
0.36	GO:0010468	regulation of gene expression
0.35	GO:0000413	protein peptidyl-prolyl isomerization
0.34	GO:0006457	protein folding

0.51	GO:0003676	nucleic acid binding
0.37	GO:0008270	zinc ion binding
0.36	GO:0003700	DNA binding transcription factor activity
0.35	GO:0003755	peptidyl-prolyl cis-trans isomerase activity

0.37	GO:0005634	nucleus
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0044425	membrane part

0.35

GO:0003755

tr|T1EE92|T1EE92_HELRO
Uncharacterized protein
Search

0.66	Synaptotagmin like 4

0.63	GO:0006887	exocytosis
0.59	GO:0006886	intracellular protein transport
0.52	GO:0017157	regulation of exocytosis
0.51	GO:0046676	negative regulation of insulin secretion
0.49	GO:0050714	positive regulation of protein secretion
0.48	GO:0071985	multivesicular body sorting pathway
0.46	GO:0048489	synaptic vesicle transport
0.46	GO:0099504	synaptic vesicle cycle
0.46	GO:0006906	vesicle fusion
0.46	GO:0099643	signal release from synapse

0.71	GO:0017137	Rab GTPase binding
0.63	GO:0005543	phospholipid binding
0.51	GO:0042043	neurexin family protein binding
0.46	GO:0019905	syntaxin binding
0.45	GO:0030276	clathrin binding
0.42	GO:0005509	calcium ion binding
0.34	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity
0.32	GO:0008270	zinc ion binding

0.51	GO:0099503	secretory vesicle
0.47	GO:0019898	extrinsic component of membrane
0.46	GO:0005815	microtubule organizing center
0.46	GO:0005768	endosome
0.45	GO:0098793	presynapse
0.44	GO:0005654	nucleoplasm
0.44	GO:0030133	transport vesicle
0.44	GO:0005829	cytosol
0.41	GO:0016324	apical plasma membrane
0.35	GO:0030659	cytoplasmic vesicle membrane

0.34	EC:2.7.1.154	GO:0035005
0.34	KEGG:R05795	GO:0035005

tr|T1EE93|T1EE93_HELRO
Uncharacterized protein
Search

MAP2K5

0.96	Dual specificity mitogen-activated protein kinase kinase 5

0.63	GO:0006468	protein phosphorylation
0.53	GO:0048731	system development
0.47	GO:0031098	stress-activated protein kinase signaling cascade
0.47	GO:0007346	regulation of mitotic cell cycle
0.46	GO:0032147	activation of protein kinase activity
0.44	GO:0042981	regulation of apoptotic process
0.44	GO:0060322	head development
0.42	GO:0043408	regulation of MAPK cascade
0.42	GO:0071481	cellular response to X-ray
0.42	GO:0042386	hemocyte differentiation

0.68	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0004713	protein tyrosine kinase activity
0.36	GO:0004708	MAP kinase kinase activity
0.35	GO:0005057	signal transducer activity, downstream of receptor
0.35	GO:0005515	protein binding
0.34	GO:0003714	transcription corepressor activity

0.51	GO:0005819	spindle
0.39	GO:0000793	condensed chromosome
0.39	GO:0005635	nuclear envelope
0.37	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.68

GO:0004674

tr|T1EE94|T1EE94_HELRO
Uncharacterized protein
Search

tr|T1EE95|T1EE95_HELRO
Uncharacterized protein
Search

0.42	GO:0036363	transforming growth factor beta activation
0.42	GO:1902462	positive regulation of mesenchymal stem cell proliferation
0.42	GO:2000741	positive regulation of mesenchymal stem cell differentiation
0.41	GO:0007160	cell-matrix adhesion
0.41	GO:0006898	receptor-mediated endocytosis
0.40	GO:0006030	chitin metabolic process
0.39	GO:0009653	anatomical structure morphogenesis
0.38	GO:0030198	extracellular matrix organization
0.38	GO:0007275	multicellular organism development
0.38	GO:0090287	regulation of cellular response to growth factor stimulus

0.70	GO:0005509	calcium ion binding
0.55	GO:0005201	extracellular matrix structural constituent
0.44	GO:0005044	scavenger receptor activity
0.41	GO:0050431	transforming growth factor beta binding
0.40	GO:0008061	chitin binding
0.37	GO:0004888	transmembrane signaling receptor activity
0.37	GO:0016504	peptidase activator activity
0.35	GO:0008270	zinc ion binding
0.35	GO:0042802	identical protein binding
0.35	GO:0003700	DNA binding transcription factor activity

0.54	GO:0031012	extracellular matrix
0.38	GO:0005615	extracellular space
0.35	GO:0009897	external side of plasma membrane
0.35	GO:0005634	nucleus
0.35	GO:0019897	extrinsic component of plasma membrane
0.35	GO:0005581	collagen trimer
0.34	GO:0099512	supramolecular fiber
0.34	GO:1903561	extracellular vesicle
0.33	GO:0031256	leading edge membrane
0.32	GO:0005938	cell cortex

0.34

GO:0004222

tr|T1EE96|T1EE96_HELRO
Uncharacterized protein
Search

0.50	Phosphotidylinositol phosphatase PTPRQ (Fragment)

0.61	GO:0006897	endocytosis
0.54	GO:0015032	storage protein import into fat body
0.53	GO:0009997	negative regulation of cardioblast cell fate specification
0.50	GO:0045747	positive regulation of Notch signaling pathway
0.47	GO:0006914	autophagy
0.41	GO:0036465	synaptic vesicle recycling
0.40	GO:0099003	vesicle-mediated transport in synapse
0.40	GO:0099643	signal release from synapse
0.40	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.39	GO:0006836	neurotransmitter transport

0.66	GO:1990175	EH domain binding
0.39	GO:0008289	lipid binding
0.35	GO:0008332	low voltage-gated calcium channel activity
0.35	GO:0009982	pseudouridine synthase activity
0.34	GO:0003723	RNA binding
0.33	GO:0043168	anion binding

0.71	GO:0030136	clathrin-coated vesicle
0.66	GO:0030666	endocytic vesicle membrane
0.62	GO:0030118	clathrin coat
0.61	GO:0030120	vesicle coat
0.57	GO:0005905	clathrin-coated pit
0.56	GO:0048471	perinuclear region of cytoplasm
0.55	GO:0019897	extrinsic component of plasma membrane
0.51	GO:0005654	nucleoplasm
0.40	GO:0098793	presynapse
0.39	GO:0005938	cell cortex

0.35

EC:5.4.99.12

GO:0009982

tr|T1EE97|T1EE97_HELRO
Uncharacterized protein
Search

CAPZA2

0.84	F-actin-capping protein subunit alpha

0.84	GO:0051016	barbed-end actin filament capping
0.45	GO:0051490	negative regulation of filopodium assembly
0.45	GO:0007294	germarium-derived oocyte fate determination
0.44	GO:0010591	regulation of lamellipodium assembly
0.44	GO:0046329	negative regulation of JNK cascade
0.43	GO:0035220	wing disc development
0.41	GO:0000902	cell morphogenesis
0.41	GO:0007015	actin filament organization
0.35	GO:0050878	regulation of body fluid levels
0.35	GO:0070495	negative regulation of thrombin-activated receptor signaling pathway

0.73	GO:0003779	actin binding
0.41	GO:0046982	protein heterodimerization activity
0.34	GO:0019903	protein phosphatase binding
0.34	GO:0004713	protein tyrosine kinase activity
0.34	GO:0042802	identical protein binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.84	GO:0008290	F-actin capping protein complex
0.51	GO:0005903	brush border
0.49	GO:0030863	cortical cytoskeleton
0.43	GO:0016324	apical plasma membrane
0.42	GO:0005912	adherens junction
0.36	GO:0070062	extracellular exosome
0.35	GO:0009925	basal plasma membrane
0.34	GO:0030018	Z disc
0.34	GO:0005829	cytosol
0.34	GO:0071203	WASH complex

0.34

GO:0004713

tr|T1EE98|T1EE98_HELRO
Histone-lysine N-methyltransferase
Search

0.47	Histone-lysine N-methyltransferase

0.79	GO:0034968	histone lysine methylation
0.50	GO:0000414	regulation of histone H3-K36 methylation
0.50	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding
0.49	GO:0045935	positive regulation of nucleobase-containing compound metabolic process
0.49	GO:0003290	atrial septum secundum morphogenesis
0.49	GO:0003289	atrial septum primum morphogenesis
0.48	GO:0033135	regulation of peptidyl-serine phosphorylation
0.48	GO:0010604	positive regulation of macromolecule metabolic process
0.48	GO:0048296	regulation of isotype switching to IgA isotypes
0.48	GO:0003149	membranous septum morphogenesis

0.79	GO:0018024	histone-lysine N-methyltransferase activity
0.54	GO:0046872	metal ion binding
0.50	GO:0050681	androgen receptor binding
0.47	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.45	GO:0003712	transcription cofactor activity
0.45	GO:0003682	chromatin binding
0.37	GO:0046965	retinoid X receptor binding
0.37	GO:0046966	thyroid hormone receptor binding
0.37	GO:0030331	estrogen receptor binding
0.34	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.36	GO:0005694	chromosome
0.35	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part
0.33	GO:0034708	methyltransferase complex
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.79

GO:0018024

tr|T1EE99|T1EE99_HELRO
Calcium-transporting ATPase
Search

0.57	Calcium-transporting ATPase

0.77	GO:0070588	calcium ion transmembrane transport
0.69	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.47	GO:0006874	cellular calcium ion homeostasis
0.39	GO:0040010	positive regulation of growth rate
0.38	GO:0002119	nematode larval development
0.38	GO:0045807	positive regulation of endocytosis
0.37	GO:0040017	positive regulation of locomotion
0.37	GO:0009792	embryo development ending in birth or egg hatching
0.36	GO:0006897	endocytosis

0.81	GO:0005388	calcium-transporting ATPase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0030165	PDZ domain binding

0.37	GO:0005886	plasma membrane
0.35	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

0.81

EC:3.6.3.8

GO:0005388

tr|T1EEA0|T1EEA0_HELRO
Uncharacterized protein
Search

ULK3

0.90	Serine-threonine-protein kinase ULK3

0.63	GO:0006468	protein phosphorylation
0.48	GO:0045880	positive regulation of smoothened signaling pathway
0.48	GO:0045879	negative regulation of smoothened signaling pathway
0.41	GO:0006914	autophagy
0.40	GO:2000786	positive regulation of autophagosome assembly
0.38	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.34	GO:0031086	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
0.33	GO:0048856	anatomical structure development
0.33	GO:0001878	response to yeast
0.33	GO:0048102	autophagic cell death

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0004518	nuclease activity
0.36	GO:0003677	DNA binding
0.34	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
0.33	GO:0003729	mRNA binding
0.33	GO:0020037	heme binding
0.33	GO:0005506	iron ion binding

0.40	GO:0005776	autophagosome
0.33	GO:1990316	Atg1/ULK1 kinase complex
0.32	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.38

EC:3.1

GO:0004518

tr|T1EEA1|T1EEA1_HELRO
Uncharacterized protein
Search

UGCG

0.67	UDP-glucose ceramide glucosyltransferase

0.49	GO:0006687	glycosphingolipid metabolic process
0.49	GO:1903955	positive regulation of protein targeting to mitochondrion
0.47	GO:0046513	ceramide biosynthetic process
0.43	GO:0009247	glycolipid biosynthetic process
0.41	GO:0043066	negative regulation of apoptotic process
0.34	GO:0008544	epidermis development

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.32	GO:0003677	DNA binding

0.41	GO:0000139	Golgi membrane
0.40	GO:0005789	endoplasmic reticulum membrane
0.32	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.65

GO:0016757

tr|T1EEA2|T1EEA2_HELRO
Ribosomal protein L37
Search

0.73	Ribosomal protein L37

0.59	GO:0043043	peptide biosynthetic process
0.55	GO:0044267	cellular protein metabolic process
0.53	GO:0010467	gene expression
0.52	GO:0009059	macromolecule biosynthetic process
0.34	GO:0034501	protein localization to kinetochore

0.64	GO:0019843	rRNA binding
0.63	GO:0003735	structural constituent of ribosome
0.52	GO:0046872	metal ion binding

0.60	GO:0005840	ribosome
0.36	GO:0044445	cytosolic part
0.35	GO:0044446	intracellular organelle part
0.33	GO:0005694	chromosome
0.32	GO:0043234	protein complex

tr|T1EEA3|T1EEA3_HELRO
Uncharacterized protein
Search

0.73	Rieske-domain protein Neverland

0.52	GO:0055114	oxidation-reduction process
0.33	GO:0006629	lipid metabolic process

0.70	GO:0051537	2 iron, 2 sulfur cluster binding
0.54	GO:0016491	oxidoreductase activity
0.33	GO:0016788	hydrolase activity, acting on ester bonds
0.33	GO:0020037	heme binding
0.33	GO:0005506	iron ion binding

0.33	GO:0005615	extracellular space
0.30	GO:0044425	membrane part

0.54

GO:0016491

tr|T1EEA4|T1EEA4_HELRO
Uncharacterized protein
Search

DNASE2

0.50	Deoxyribonuclease II

0.60	GO:0006259	DNA metabolic process
0.48	GO:0030218	erythrocyte differentiation
0.47	GO:0030262	apoptotic nuclear changes
0.46	GO:0034655	nucleobase-containing compound catabolic process
0.46	GO:0044265	cellular macromolecule catabolic process
0.44	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.40	GO:0045476	nurse cell apoptotic process
0.33	GO:0009405	pathogenesis
0.32	GO:0007165	signal transduction
0.32	GO:0009116	nucleoside metabolic process

0.84	GO:0004531	deoxyribonuclease II activity
0.38	GO:0043022	ribosome binding
0.38	GO:0005509	calcium ion binding
0.34	GO:0090729	toxin activity
0.33	GO:0004749	ribose phosphate diphosphokinase activity
0.32	GO:0003677	DNA binding
0.32	GO:0000287	magnesium ion binding

0.38	GO:0005764	lysosome
0.36	GO:0005576	extracellular region
0.36	GO:0005739	mitochondrion
0.34	GO:0031982	vesicle
0.30	GO:0016020	membrane

0.84	EC:3.1.22.1	GO:0004531
0.33	KEGG:R01049	GO:0004749

tr|T1EEA5|T1EEA5_HELRO
Uncharacterized protein
Search

0.40	Putative septin family protein p-loop gtpase

0.62	GO:0051301	cell division
0.62	GO:0007049	cell cycle
0.48	GO:0002036	regulation of L-glutamate transport
0.45	GO:0007224	smoothened signaling pathway
0.44	GO:0060271	cilium assembly
0.43	GO:0032880	regulation of protein localization
0.41	GO:0043065	positive regulation of apoptotic process
0.41	GO:0050790	regulation of catalytic activity
0.36	GO:0007283	spermatogenesis
0.36	GO:0032502	developmental process

0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0045296	cadherin binding
0.45	GO:0032947	protein complex scaffold activity
0.42	GO:0030234	enzyme regulator activity
0.41	GO:0031625	ubiquitin protein ligase binding
0.41	GO:0042802	identical protein binding
0.40	GO:0003924	GTPase activity

0.51	GO:0031105	septin complex
0.48	GO:0097227	sperm annulus
0.46	GO:0032391	photoreceptor connecting cilium
0.46	GO:0060170	ciliary membrane
0.45	GO:0043209	myelin sheath
0.45	GO:0005930	axoneme
0.43	GO:0009986	cell surface
0.43	GO:0045202	synapse
0.39	GO:0005634	nucleus
0.37	GO:0030496	midbody

0.34

EC:2.7.11.19

GO:0004689

tr|T1EEA6|T1EEA6_HELRO
Uncharacterized protein
Search

0.78	GO:0072659	protein localization to plasma membrane
0.68	GO:0030097	hemopoiesis
0.66	GO:0006879	cellular iron ion homeostasis
0.52	GO:0046854	phosphatidylinositol phosphorylation

0.49	GO:0005829	cytosol
0.43	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEA7|T1EEA7_HELRO
Receptor protein serine/threonine kinase
Search

0.35	Receptor protein serine/threonine kinase

0.80	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.66	GO:0023014	signal transduction by protein phosphorylation
0.59	GO:0071560	cellular response to transforming growth factor beta stimulus
0.44	GO:0040008	regulation of growth
0.44	GO:0006915	apoptotic process
0.43	GO:0030154	cell differentiation
0.40	GO:0032927	positive regulation of activin receptor signaling pathway
0.39	GO:0030501	positive regulation of bone mineralization
0.39	GO:0045669	positive regulation of osteoblast differentiation
0.39	GO:0071773	cellular response to BMP stimulus

0.79	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
0.72	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0046872	metal ion binding
0.38	GO:0019838	growth factor binding
0.38	GO:0048185	activin binding
0.37	GO:0004712	protein serine/threonine/tyrosine kinase activity
0.32	GO:0004930	G-protein coupled receptor activity

0.58	GO:0043235	receptor complex
0.38	GO:0005886	plasma membrane
0.35	GO:0043234	protein complex
0.33	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.79

GO:0004702

tr|T1EEA8|T1EEA8_HELRO
Uncharacterized protein
Search

0.11	Tripeptidyl-peptidase 2

0.61	GO:0006508	proteolysis
0.35	GO:0000209	protein polyubiquitination

0.86	GO:0008240	tripeptidyl-peptidase activity
0.69	GO:0004252	serine-type endopeptidase activity
0.38	GO:0042277	peptide binding
0.38	GO:0004177	aminopeptidase activity
0.37	GO:0042802	identical protein binding
0.34	GO:0005509	calcium ion binding

0.51	GO:0016604	nuclear body
0.47	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.86

EC:3.4.14

GO:0008240

tr|T1EEA9|T1EEA9_HELRO
Mitogen-activated protein kinase
Search

NLK

0.57	Mitogen-activated protein kinase

0.77	GO:0000165	MAPK cascade
0.49	GO:0046777	protein autophosphorylation
0.49	GO:0030111	regulation of Wnt signaling pathway
0.48	GO:0042501	serine phosphorylation of STAT protein
0.47	GO:0007179	transforming growth factor beta receptor signaling pathway
0.47	GO:0018107	peptidyl-threonine phosphorylation
0.46	GO:0042332	gravitaxis
0.46	GO:0016318	ommatidial rotation
0.45	GO:0045887	positive regulation of synaptic growth at neuromuscular junction
0.45	GO:0007474	imaginal disc-derived wing vein specification

0.79	GO:0004707	MAP kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0031625	ubiquitin protein ligase binding
0.46	GO:0042169	SH2 domain binding
0.44	GO:0008134	transcription factor binding
0.40	GO:0000287	magnesium ion binding
0.34	GO:0047485	protein N-terminus binding
0.34	GO:0008013	beta-catenin binding

0.44	GO:0005622	intracellular
0.40	GO:0043227	membrane-bounded organelle
0.34	GO:1902554	serine/threonine protein kinase complex
0.32	GO:0071944	cell periphery
0.30	GO:0016020	membrane

0.79	EC:2.7.11.24	GO:0004707
0.79	KEGG:R00162	GO:0004707

tr|T1EEB0|T1EEB0_HELRO
Sideroflexin
Search

0.80	Sideroflexin

0.60	GO:0034220	ion transmembrane transport
0.35	GO:0055072	iron ion homeostasis
0.34	GO:0035335	peptidyl-tyrosine dephosphorylation

0.60	GO:0015075	ion transmembrane transporter activity
0.34	GO:0004725	protein tyrosine phosphatase activity

0.60	GO:0031966	mitochondrial membrane
0.41	GO:0019866	organelle inner membrane
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0004725

tr|T1EEB1|T1EEB1_HELRO
Uncharacterized protein
Search

0.42	Elongation factor Tu

0.40	GO:0006414	translational elongation
0.33	GO:0006313	transposition, DNA-mediated

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0003746	translation elongation factor activity
0.33	GO:0004803	transposase activity
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0003677	DNA binding

0.33

GO:0005840

ribosome

tr|T1EEB2|T1EEB2_HELRO
Receptor protein serine/threonine kinase
Search

0.37	Receptor protein serine/threonine kinase

0.80	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.66	GO:0023014	signal transduction by protein phosphorylation
0.49	GO:0071363	cellular response to growth factor stimulus
0.48	GO:0046588	negative regulation of calcium-dependent cell-cell adhesion
0.48	GO:0035124	embryonic caudal fin morphogenesis
0.47	GO:0021556	central nervous system formation
0.47	GO:0048264	determination of ventral identity
0.47	GO:0035462	determination of left/right asymmetry in diencephalon
0.47	GO:0003343	septum transversum development
0.47	GO:0071495	cellular response to endogenous stimulus

0.80	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
0.79	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.40	GO:0046872	metal ion binding
0.36	GO:0036122	BMP binding

0.48	GO:0043235	receptor complex
0.42	GO:0005938	cell cortex
0.40	GO:0005887	integral component of plasma membrane
0.33	GO:0005634	nucleus

0.80

GO:0004675

tr|T1EEB3|T1EEB3_HELRO
Uncharacterized protein
Search

0.44	GO:0045944	positive regulation of transcription by RNA polymerase II
0.44	GO:0006366	transcription by RNA polymerase II
0.39	GO:0021634	optic nerve formation
0.38	GO:0043249	erythrocyte maturation
0.37	GO:0035265	organ growth
0.37	GO:0031016	pancreas development
0.37	GO:0001889	liver development
0.37	GO:0048565	digestive tract development
0.36	GO:0000122	negative regulation of transcription by RNA polymerase II
0.35	GO:0019221	cytokine-mediated signaling pathway

0.51	GO:0003676	nucleic acid binding
0.46	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.37	GO:0008270	zinc ion binding
0.37	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.36	GO:0003682	chromatin binding
0.32	GO:0005515	protein binding

0.46	GO:0001650	fibrillar center
0.41	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEB4|T1EEB4_HELRO
Ribosome biogenesis protein WDR12 homolog
Search

0.46	Ribosome biogenesis protein WDR12

0.77	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.76	GO:0000460	maturation of 5.8S rRNA
0.39	GO:1901800	positive regulation of proteasomal protein catabolic process
0.38	GO:0006378	mRNA polyadenylation
0.37	GO:0030163	protein catabolic process
0.36	GO:0045666	positive regulation of neuron differentiation
0.36	GO:0000387	spliceosomal snRNP assembly
0.36	GO:0006468	protein phosphorylation
0.36	GO:1902531	regulation of intracellular signal transduction
0.35	GO:0043547	positive regulation of GTPase activity

0.69	GO:0043021	ribonucleoprotein complex binding
0.39	GO:0036402	proteasome-activating ATPase activity
0.37	GO:0003729	mRNA binding
0.36	GO:0004674	protein serine/threonine kinase activity
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.35	GO:0005096	GTPase activator activity
0.32	GO:0046872	metal ion binding

0.76	GO:0030687	preribosome, large subunit precursor
0.72	GO:0005730	nucleolus
0.68	GO:0005654	nucleoplasm
0.39	GO:0030686	90S preribosome
0.37	GO:0043234	protein complex
0.34	GO:0055044	symplast
0.34	GO:0005737	cytoplasm
0.34	GO:0005911	cell-cell junction
0.33	GO:0038201	TOR complex

0.36

GO:0004674

tr|T1EEB5|T1EEB5_HELRO
Uncharacterized protein
Search

RPS6

0.67	Ribosomal protein 6 (Fragment)

0.60	GO:0043043	peptide biosynthetic process
0.55	GO:0044267	cellular protein metabolic process
0.53	GO:0010467	gene expression
0.52	GO:0009059	macromolecule biosynthetic process
0.50	GO:0002309	T cell proliferation involved in immune response
0.50	GO:0022605	oogenesis stage
0.50	GO:0006924	activation-induced cell death of T cells
0.48	GO:0048821	erythrocyte development
0.48	GO:0033077	T cell differentiation in thymus
0.47	GO:0042593	glucose homeostasis

0.63	GO:0003735	structural constituent of ribosome
0.45	GO:0019901	protein kinase binding
0.34	GO:0003729	mRNA binding

0.61	GO:0005840	ribosome
0.48	GO:0030425	dendrite
0.47	GO:0005844	polysome
0.46	GO:0044445	cytosolic part
0.46	GO:0048471	perinuclear region of cytoplasm
0.46	GO:0044297	cell body
0.45	GO:0036464	cytoplasmic ribonucleoprotein granule
0.43	GO:0005730	nucleolus
0.42	GO:0005783	endoplasmic reticulum
0.33	GO:0005654	nucleoplasm

tr|T1EEB6|T1EEB6_HELRO
tRNA-dihydrouridine synthase
Search

DUS4L

0.54	tRNA-dihydrouridine synthase

0.77	GO:0002943	tRNA dihydrouridine synthesis
0.53	GO:0055114	oxidation-reduction process
0.34	GO:0019236	response to pheromone
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0006887	exocytosis

0.77	GO:0017150	tRNA dihydrouridine synthase activity
0.66	GO:0050660	flavin adenine dinucleotide binding
0.32	GO:0003676	nucleic acid binding

0.33	GO:0000145	exocyst
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEB7|T1EEB7_HELRO
Uncharacterized protein
Search

0.39	WW domain containing E3 ubiquitin protein ligase 1

0.72	GO:0016567	protein ubiquitination
0.71	GO:0006511	ubiquitin-dependent protein catabolic process
0.53	GO:0043433	negative regulation of DNA binding transcription factor activity
0.52	GO:0002669	positive regulation of T cell anergy
0.51	GO:0046642	negative regulation of alpha-beta T cell proliferation
0.51	GO:2000646	positive regulation of receptor catabolic process
0.51	GO:0090085	regulation of protein deubiquitination
0.50	GO:0050687	negative regulation of defense response to virus
0.50	GO:0046329	negative regulation of JNK cascade
0.48	GO:0010498	proteasomal protein catabolic process

0.74	GO:0061630	ubiquitin protein ligase activity
0.56	GO:0016874	ligase activity
0.52	GO:1990763	arrestin family protein binding
0.50	GO:0045236	CXCR chemokine receptor binding
0.47	GO:0044389	ubiquitin-like protein ligase binding
0.45	GO:0043021	ribonucleoprotein complex binding
0.44	GO:0001085	RNA polymerase II transcription factor binding
0.44	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding

0.47	GO:0005769	early endosome
0.46	GO:0005938	cell cortex
0.44	GO:0005634	nucleus
0.43	GO:0070013	intracellular organelle lumen
0.40	GO:0005576	extracellular region
0.40	GO:0043234	protein complex
0.39	GO:0044446	intracellular organelle part
0.39	GO:0005886	plasma membrane
0.34	GO:0098805	whole membrane
0.34	GO:0098588	bounding membrane of organelle

0.56

GO:0016874

tr|T1EEB8|T1EEB8_HELRO
Uncharacterized protein
Search

TRAPPC12

0.61	Trafficking protein particle complex subunit 12

0.82	GO:0090234	regulation of kinetochore assembly
0.79	GO:1905342	positive regulation of protein localization to kinetochore
0.75	GO:0051310	metaphase plate congression
0.73	GO:0007030	Golgi organization
0.69	GO:0006888	ER to Golgi vesicle-mediated transport
0.65	GO:0051259	protein oligomerization
0.51	GO:0006508	proteolysis
0.36	GO:0065009	regulation of molecular function

0.52	GO:0070011	peptidase activity, acting on L-amino acid peptides
0.38	GO:0017112	Rab guanyl-nucleotide exchange factor activity

0.74	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.72	GO:0030008	TRAPP complex
0.70	GO:0048471	perinuclear region of cytoplasm
0.69	GO:0000776	kinetochore
0.56	GO:0005634	nucleus
0.36	GO:0005829	cytosol

tr|T1EEB9|T1EEB9_HELRO
Uncharacterized protein
Search

0.64	ARV1 homolog, fatty acid homeostasis modulator

0.60	GO:0032383	regulation of intracellular cholesterol transport
0.60	GO:0090181	regulation of cholesterol metabolic process
0.59	GO:0015918	sterol transport
0.59	GO:0008206	bile acid metabolic process
0.52	GO:0097036	regulation of plasma membrane sterol distribution
0.49	GO:0032365	intracellular lipid transport
0.47	GO:0006665	sphingolipid metabolic process
0.47	GO:0016125	sterol metabolic process
0.37	GO:1902652	secondary alcohol metabolic process
0.34	GO:0006694	steroid biosynthetic process

0.35	GO:0015248	sterol transporter activity
0.34	GO:0047874	dolichyldiphosphatase activity

0.52	GO:0098827	endoplasmic reticulum subcompartment
0.51	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.46	GO:0044448	cell cortex part
0.45	GO:0005794	Golgi apparatus
0.30	GO:0031224	intrinsic component of membrane

0.34

EC:3.6.1.43

GO:0047874

tr|T1EEC0|T1EEC0_HELRO
Uncharacterized protein
Search

0.75	High affinity copper uptake protein 1

0.81	GO:0035434	copper ion transmembrane transport
0.45	GO:0006878	cellular copper ion homeostasis
0.44	GO:0002027	regulation of heart rate
0.39	GO:0015677	copper ion import
0.35	GO:0072719	cellular response to cisplatin
0.34	GO:0010038	response to metal ion
0.34	GO:0099587	inorganic ion import across plasma membrane
0.34	GO:0042539	hypotonic salinity response
0.34	GO:0071391	cellular response to estrogen stimulus
0.33	GO:0007283	spermatogenesis

0.82	GO:0005375	copper ion transmembrane transporter activity
0.36	GO:0042802	identical protein binding

0.37	GO:0005886	plasma membrane
0.37	GO:0055037	recycling endosome
0.36	GO:0005770	late endosome
0.34	GO:0043025	neuronal cell body
0.33	GO:0000329	fungal-type vacuole membrane
0.30	GO:0016021	integral component of membrane

tr|T1EEC1|T1EEC1_HELRO
Uncharacterized protein
Search

0.39	Guanylate cyclase

0.81	GO:0006182	cGMP biosynthetic process
0.63	GO:0035556	intracellular signal transduction
0.62	GO:0006468	protein phosphorylation
0.42	GO:0060038	cardiac muscle cell proliferation
0.40	GO:0007168	receptor guanylyl cyclase signaling pathway
0.37	GO:0018212	peptidyl-tyrosine modification
0.37	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus
0.36	GO:1900194	negative regulation of oocyte maturation
0.35	GO:0051447	negative regulation of meiotic cell cycle
0.35	GO:0060348	bone development

0.81	GO:0004383	guanylate cyclase activity
0.62	GO:0004672	protein kinase activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0004016	adenylate cyclase activity
0.41	GO:0016941	natriuretic peptide receptor activity
0.37	GO:0017046	peptide hormone binding
0.34	GO:0042802	identical protein binding
0.33	GO:0032550	purine ribonucleoside binding

0.45	GO:0005622	intracellular
0.37	GO:0043234	protein complex
0.37	GO:0005886	plasma membrane
0.33	GO:0044297	cell body
0.33	GO:0043005	neuron projection
0.33	GO:0099512	supramolecular fiber
0.32	GO:0043228	non-membrane-bounded organelle
0.32	GO:0044422	organelle part
0.30	GO:0016021	integral component of membrane

0.81

GO:0004383

tr|T1EEC2|T1EEC2_HELRO
Phosphodiesterase
Search

0.23	Phosphodiesterase

0.60	GO:0007165	signal transduction
0.43	GO:0007608	sensory perception of smell
0.38	GO:0006198	cAMP catabolic process
0.36	GO:0035690	cellular response to drug
0.36	GO:0001780	neutrophil homeostasis
0.36	GO:0051592	response to calcium ion
0.36	GO:0032743	positive regulation of interleukin-2 production
0.36	GO:0030593	neutrophil chemotaxis
0.35	GO:0032729	positive regulation of interferon-gamma production
0.35	GO:0071222	cellular response to lipopolysaccharide

0.79	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.54	GO:0046872	metal ion binding
0.38	GO:0030552	cAMP binding
0.36	GO:0005516	calmodulin binding
0.35	GO:0043015	gamma-tubulin binding

0.43	GO:0005929	cilium
0.36	GO:0036477	somatodendritic compartment
0.36	GO:0060076	excitatory synapse
0.36	GO:0005829	cytosol
0.35	GO:0044309	neuron spine
0.35	GO:0014069	postsynaptic density
0.35	GO:0000930	gamma-tubulin complex
0.35	GO:0008021	synaptic vesicle
0.35	GO:0005813	centrosome
0.35	GO:0120038	plasma membrane bounded cell projection part

0.79

EC:3.1.4.17

GO:0004114

tr|T1EEC3|T1EEC3_HELRO
Protein yippee-like
Search

tr|T1EEC4|T1EEC4_HELRO
Uncharacterized protein
Search

CCNK

0.85

Cyclin-K

0.57	GO:1901409	positive regulation of phosphorylation of RNA polymerase II C-terminal domain
0.56	GO:0044828	negative regulation by host of viral genome replication
0.55	GO:2001163	regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
0.54	GO:0071157	negative regulation of cell cycle arrest
0.49	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
0.46	GO:0045944	positive regulation of transcription by RNA polymerase II
0.44	GO:0006974	cellular response to DNA damage stimulus
0.44	GO:0006468	protein phosphorylation
0.37	GO:2000737	negative regulation of stem cell differentiation
0.37	GO:0001701	in utero embryonic development

0.52	GO:0004693	cyclin-dependent protein serine/threonine kinase activity
0.52	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.50	GO:0019901	protein kinase binding
0.48	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity

0.59	GO:0005634	nucleus
0.56	GO:0002944	cyclin K-CDK12 complex
0.56	GO:0002945	cyclin K-CDK13 complex
0.46	GO:0043233	organelle lumen
0.42	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.52

EC:2.7.11.22

GO:0004693

tr|T1EEC5|T1EEC5_HELRO
Uncharacterized protein
Search

0.91	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase

0.51	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
0.46	GO:0090098	positive regulation of decapentaplegic signaling pathway
0.46	GO:0007509	mesoderm migration involved in gastrulation
0.46	GO:0007427	epithelial cell migration, open tracheal system
0.45	GO:0045570	regulation of imaginal disc growth
0.45	GO:0007367	segment polarity determination
0.45	GO:0007474	imaginal disc-derived wing vein specification
0.45	GO:0008587	imaginal disc-derived wing margin morphogenesis
0.45	GO:0048312	intracellular distribution of mitochondria
0.45	GO:0048488	synaptic vesicle endocytosis

0.86	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity
0.51	GO:0016787	hydrolase activity
0.45	GO:0042328	heparan sulfate N-acetylglucosaminyltransferase activity

0.44	GO:0000137	Golgi cis cisterna
0.42	GO:0045202	synapse
0.40	GO:0005783	endoplasmic reticulum
0.36	GO:0000139	Golgi membrane
0.30	GO:0016021	integral component of membrane

0.86

EC:2.8.2.8

GO:0015016

tr|T1EEC6|T1EEC6_HELRO
Uncharacterized protein
Search

PRPF40B

0.84	Huntingtin-interacting protein C

0.66	GO:0000398	mRNA splicing, via spliceosome
0.53	GO:0032465	regulation of cytokinesis
0.53	GO:0016477	cell migration
0.49	GO:0007010	cytoskeleton organization
0.49	GO:0008360	regulation of cell shape
0.42	GO:0006400	tRNA modification
0.42	GO:0010133	proline catabolic process to glutamate
0.39	GO:1903830	magnesium ion transmembrane transport
0.35	GO:0055114	oxidation-reduction process

0.58	GO:0070064	proline-rich region binding
0.53	GO:0003723	RNA binding
0.45	GO:0051539	4 iron, 4 sulfur cluster binding
0.42	GO:0003842	1-pyrroline-5-carboxylate dehydrogenase activity
0.39	GO:0015095	magnesium ion transmembrane transporter activity
0.39	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.37	GO:0016740	transferase activity

0.73	GO:0071004	U2-type prespliceosome
0.72	GO:0005685	U1 snRNP
0.58	GO:0016607	nuclear speck
0.56	GO:0016363	nuclear matrix
0.48	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.42

EC:1.5.1.12

GO:0003842

tr|T1EEC7|T1EEC7_HELRO
Uncharacterized protein
Search

0.86	Twinfilin actin binding protein 1

0.80	GO:0030837	negative regulation of actin filament polymerization
0.49	GO:0010591	regulation of lamellipodium assembly
0.48	GO:0051239	regulation of multicellular organismal process
0.47	GO:0071300	cellular response to retinoic acid
0.47	GO:1902745	positive regulation of lamellipodium organization
0.47	GO:0120034	positive regulation of plasma membrane bounded cell projection assembly
0.47	GO:0061387	regulation of extent of cell growth
0.46	GO:0010770	positive regulation of cell morphogenesis involved in differentiation
0.46	GO:0030307	positive regulation of cell growth
0.46	GO:0048639	positive regulation of developmental growth

0.74	GO:0003779	actin binding
0.50	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.48	GO:0045296	cadherin binding
0.47	GO:0005080	protein kinase C binding
0.39	GO:0004713	protein tyrosine kinase activity
0.39	GO:0030554	adenyl nucleotide binding
0.39	GO:0032403	protein complex binding
0.39	GO:0004888	transmembrane signaling receptor activity
0.39	GO:0097367	carbohydrate derivative binding
0.39	GO:0035639	purine ribonucleoside triphosphate binding

0.50	GO:0030175	filopodium
0.49	GO:0048471	perinuclear region of cytoplasm
0.48	GO:0031252	cell leading edge
0.47	GO:0032420	stereocilium
0.46	GO:0030426	growth cone
0.42	GO:0030016	myofibril
0.41	GO:0005856	cytoskeleton
0.40	GO:0031253	cell projection membrane
0.39	GO:0005911	cell-cell junction
0.38	GO:0005829	cytosol

0.39

GO:0004713

tr|T1EEC8|T1EEC8_HELRO
Uncharacterized protein
Search

0.67	GO:2000506	negative regulation of energy homeostasis
0.66	GO:2001170	negative regulation of ATP biosynthetic process
0.66	GO:1901723	negative regulation of cell proliferation involved in kidney development
0.66	GO:0065009	regulation of molecular function
0.66	GO:2000973	regulation of pro-B cell differentiation
0.64	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
0.63	GO:0010823	negative regulation of mitochondrion organization
0.63	GO:0051898	negative regulation of protein kinase B signaling
0.63	GO:1901874	negative regulation of post-translational protein modification
0.62	GO:0070373	negative regulation of ERK1 and ERK2 cascade

0.75	GO:0005085	guanyl-nucleotide exchange factor activity
0.53	GO:0032403	protein complex binding
0.30	GO:0003824	catalytic activity

0.58	GO:0044291	cell-cell contact zone
0.57	GO:0030496	midbody
0.46	GO:0005634	nucleus
0.43	GO:0005886	plasma membrane
0.40	GO:0005737	cytoplasm
0.35	GO:0005929	cilium

tr|T1EEC9|T1EEC9_HELRO
Uncharacterized protein
Search

0.66	Ethanolamine-phosphate cytidylyltransferase

0.49	GO:0009058	biosynthetic process
0.38	GO:0042439	ethanolamine-containing compound metabolic process
0.37	GO:0046337	phosphatidylethanolamine metabolic process

0.56	GO:0016779	nucleotidyltransferase activity
0.35	GO:0070403	NAD+ binding
0.33	GO:0003723	RNA binding

0.34

GO:0005789

endoplasmic reticulum membrane

0.56

GO:0016779

tr|T1EED0|T1EED0_HELRO
Uncharacterized protein
Search

0.79	GO:0060079	excitatory postsynaptic potential
0.60	GO:0034220	ion transmembrane transport
0.51	GO:0035094	response to nicotine
0.51	GO:0007271	synaptic transmission, cholinergic
0.48	GO:0060080	inhibitory postsynaptic potential
0.47	GO:0051952	regulation of amine transport
0.47	GO:0035640	exploration behavior
0.47	GO:0007585	respiratory gaseous exchange
0.46	GO:2001023	regulation of response to drug
0.46	GO:0051899	membrane depolarization

0.82	GO:0022848	acetylcholine-gated cation-selective channel activity
0.70	GO:0099600	transmembrane receptor activity
0.46	GO:0042166	acetylcholine binding
0.34	GO:0005515	protein binding
0.33	GO:0022850	serotonin-gated cation-selective channel activity
0.33	GO:0003777	microtubule motor activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.78	GO:0045211	postsynaptic membrane
0.73	GO:0030054	cell junction
0.52	GO:0005892	acetylcholine-gated channel complex
0.45	GO:0009897	external side of plasma membrane
0.37	GO:0043025	neuronal cell body
0.36	GO:0043005	neuron projection
0.36	GO:0031594	neuromuscular junction
0.34	GO:0120038	plasma membrane bounded cell projection part

tr|T1EED1|T1EED1_HELRO
Uncharacterized protein
Search

0.22	Receptor-type tyrosine-protein phosphatase epsilon isoform A

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.44	GO:0035096	larval midgut cell programmed cell death
0.44	GO:0035075	response to ecdysone
0.43	GO:0008045	motor neuron axon guidance
0.38	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway
0.38	GO:0021587	cerebellum morphogenesis
0.37	GO:0043409	negative regulation of MAPK cascade
0.37	GO:0006469	negative regulation of protein kinase activity
0.36	GO:0043116	negative regulation of vascular permeability
0.36	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway

0.75	GO:0004725	protein tyrosine phosphatase activity
0.50	GO:0019198	transmembrane receptor protein phosphatase activity
0.36	GO:0070097	delta-catenin binding
0.36	GO:0045295	gamma-catenin binding
0.35	GO:0005161	platelet-derived growth factor receptor binding
0.35	GO:0051019	mitogen-activated protein kinase binding
0.35	GO:0033549	MAP kinase phosphatase activity
0.35	GO:0008013	beta-catenin binding
0.33	GO:0004672	protein kinase activity
0.33	GO:0003777	microtubule motor activity

0.39	GO:0005887	integral component of plasma membrane
0.35	GO:0001772	immunological synapse
0.34	GO:0005911	cell-cell junction
0.34	GO:0009986	cell surface
0.33	GO:0016459	myosin complex
0.33	GO:0005829	cytosol
0.32	GO:0005634	nucleus
0.32	GO:0005739	mitochondrion
0.32	GO:0031982	vesicle

0.75

GO:0004725

tr|T1EED2|T1EED2_HELRO
Uncharacterized protein
Search

0.42	GO:0007010	cytoskeleton organization
0.42	GO:0006357	regulation of transcription by RNA polymerase II
0.42	GO:0007275	multicellular organism development
0.42	GO:0022604	regulation of cell morphogenesis
0.32	GO:0007154	cell communication

0.63	GO:0008270	zinc ion binding
0.43	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.41	GO:0031624	ubiquitin conjugating enzyme binding
0.38	GO:0003677	DNA binding
0.32	GO:0005509	calcium ion binding

0.43	GO:0005654	nucleoplasm
0.36	GO:0005737	cytoplasm
0.32	GO:0019867	outer membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1EED3|T1EED3_HELRO
Uncharacterized protein
Search

0.58	Zinc finger protein 622

0.53	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
0.51	GO:0046330	positive regulation of JNK cascade
0.49	GO:0043065	positive regulation of apoptotic process
0.49	GO:0033674	positive regulation of kinase activity
0.43	GO:0042273	ribosomal large subunit biogenesis
0.34	GO:0061709	reticulophagy
0.32	GO:0007117	budding cell bud growth
0.32	GO:0000278	mitotic cell cycle
0.32	GO:0006913	nucleocytoplasmic transport

0.61	GO:0008270	zinc ion binding
0.50	GO:0003676	nucleic acid binding
0.33	GO:0005515	protein binding

0.47	GO:0005730	nucleolus
0.46	GO:0005829	cytosol
0.46	GO:0005794	Golgi apparatus
0.44	GO:0030687	preribosome, large subunit precursor
0.42	GO:0015934	large ribosomal subunit
0.33	GO:0030176	integral component of endoplasmic reticulum membrane

tr|T1EED4|T1EED4_HELRO
Peptidyl-prolyl cis-trans isomerase E
Search

PPIE

0.41	Peptidyl-prolyl cis-trans isomerase E

0.72	GO:0000413	protein peptidyl-prolyl isomerization
0.68	GO:0006457	protein folding
0.39	GO:0000398	mRNA splicing, via spliceosome
0.38	GO:0006309	apoptotic DNA fragmentation
0.38	GO:0045070	positive regulation of viral genome replication
0.35	GO:0046686	response to cadmium ion
0.34	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression
0.32	GO:0007165	signal transduction

0.72	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.57	GO:0003723	RNA binding
0.35	GO:0008270	zinc ion binding
0.35	GO:0004518	nuclease activity
0.35	GO:0016018	cyclosporin A binding
0.33	GO:0005515	protein binding
0.32	GO:0003677	DNA binding

0.37	GO:0071007	U2-type catalytic step 2 spliceosome
0.37	GO:0016607	nuclear speck
0.36	GO:0005829	cytosol
0.34	GO:0005794	Golgi apparatus
0.33	GO:0005739	mitochondrion
0.33	GO:0089701	U2AF

0.72

GO:0003755

tr|T1EED5|T1EED5_HELRO
Uncharacterized protein
Search

tr|T1EED6|T1EED6_HELRO
Uncharacterized protein
Search

tr|T1EED7|T1EED7_HELRO
Uncharacterized protein
Search

0.86	cDNA, FLJ93859, highly similar to Homo sapiens protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform (PPM1A), mRNA

0.72	GO:0006470	protein dephosphorylation
0.52	GO:0010991	negative regulation of SMAD protein complex assembly
0.52	GO:0042347	negative regulation of NF-kappaB import into nucleus
0.51	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.50	GO:0046827	positive regulation of protein export from nucleus
0.49	GO:0006499	N-terminal protein myristoylation
0.49	GO:0030514	negative regulation of BMP signaling pathway
0.49	GO:0030177	positive regulation of Wnt signaling pathway
0.48	GO:0071560	cellular response to transforming growth factor beta stimulus
0.47	GO:0016055	Wnt signaling pathway

0.77	GO:0004722	protein serine/threonine phosphatase activity
0.72	GO:0030145	manganese ion binding
0.64	GO:0000287	magnesium ion binding
0.51	GO:0070412	R-SMAD binding
0.34	GO:0008022	protein C-terminus binding
0.34	GO:0004871	signal transducer activity

0.44	GO:0005829	cytosol
0.42	GO:0005634	nucleus
0.39	GO:0005886	plasma membrane
0.34	GO:0031974	membrane-enclosed lumen
0.34	GO:0034704	calcium channel complex
0.34	GO:0043005	neuron projection
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0044446	intracellular organelle part

tr|T1EED8|T1EED8_HELRO
Uncharacterized protein
Search

0.61	G protein-activated inward rectifier potassium channel 4

0.77	GO:0034765	regulation of ion transmembrane transport
0.71	GO:0006813	potassium ion transport
0.61	GO:0098655	cation transmembrane transport
0.39	GO:0046662	regulation of oviposition
0.39	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.38	GO:0098660	inorganic ion transmembrane transport
0.34	GO:0051876	pigment granule dispersal
0.34	GO:0051877	pigment granule aggregation in cell center
0.34	GO:0097324	melanocyte migration
0.34	GO:0006836	neurotransmitter transport

0.84	GO:0005242	inward rectifier potassium channel activity
0.34	GO:0005328	neurotransmitter:sodium symporter activity
0.34	GO:0005044	scavenger receptor activity
0.32	GO:0008270	zinc ion binding
0.32	GO:0003676	nucleic acid binding

0.39	GO:0005887	integral component of plasma membrane
0.38	GO:0043025	neuronal cell body
0.38	GO:0043005	neuron projection

tr|T1EED9|T1EED9_HELRO
Uncharacterized protein
Search

LRRC40

0.93	Leucine-rich repeat-containing protein 40

0.61

GO:0007165

signal transduction

0.56	GO:0005886	plasma membrane
0.36	GO:0005829	cytosol

tr|T1EEE0|T1EEE0_HELRO
Uncharacterized protein
Search

tr|T1EEE1|T1EEE1_HELRO
Uncharacterized protein
Search

DYNC1I2

0.90	Cytoplasmic dynein 1 intermediate chain 2

0.73	GO:0007018	microtubule-based movement
0.47	GO:2000582	positive regulation of ATP-dependent microtubule motor activity, plus-end-directed
0.45	GO:0030705	cytoskeleton-dependent intracellular transport
0.35	GO:0097711	ciliary basal body-plasma membrane docking
0.35	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.34	GO:1990090	cellular response to nerve growth factor stimulus
0.34	GO:0000086	G2/M transition of mitotic cell cycle
0.34	GO:0010977	negative regulation of neuron projection development
0.34	GO:0010389	regulation of G2/M transition of mitotic cell cycle
0.34	GO:0051276	chromosome organization

0.47	GO:0045504	dynein heavy chain binding
0.46	GO:0045503	dynein light chain binding
0.46	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed
0.34	GO:0004402	histone acetyltransferase activity
0.33	GO:0032403	protein complex binding
0.32	GO:0016301	kinase activity

0.82	GO:0005868	cytoplasmic dynein complex
0.46	GO:0005813	centrosome
0.45	GO:0005874	microtubule
0.44	GO:0031982	vesicle
0.34	GO:0030426	growth cone
0.34	GO:0043025	neuronal cell body
0.34	GO:0030424	axon
0.33	GO:0005737	cytoplasm
0.32	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016020	membrane

0.46

EC:3.6.4.4

GO:0008574

tr|T1EEE2|T1EEE2_HELRO
Uncharacterized protein
Search

FURIN

0.37	Truncated furin endoprotease

0.61	GO:0006508	proteolysis
0.51	GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process
0.51	GO:0032902	nerve growth factor production
0.50	GO:0032911	negative regulation of transforming growth factor beta1 production
0.50	GO:0051604	protein maturation
0.49	GO:0045714	regulation of low-density lipoprotein particle receptor biosynthetic process
0.47	GO:0048240	sperm capacitation
0.47	GO:0008037	cell recognition
0.47	GO:0042445	hormone metabolic process
0.46	GO:0007340	acrosome reaction

0.69	GO:0004252	serine-type endopeptidase activity
0.50	GO:0048406	nerve growth factor binding
0.47	GO:0002020	protease binding
0.46	GO:0042277	peptide binding
0.46	GO:0004867	serine-type endopeptidase inhibitor activity
0.37	GO:0005102	receptor binding
0.34	GO:0046872	metal ion binding
0.34	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.48	GO:0031410	cytoplasmic vesicle
0.48	GO:0098805	whole membrane
0.47	GO:0098588	bounding membrane of organelle
0.46	GO:0012505	endomembrane system
0.45	GO:0097223	sperm part
0.45	GO:0009986	cell surface
0.43	GO:0012506	vesicle membrane
0.42	GO:0031984	organelle subcompartment
0.39	GO:0043025	neuronal cell body
0.39	GO:0043231	intracellular membrane-bounded organelle

0.69

GO:0004252

tr|T1EEE3|T1EEE3_HELRO
Uncharacterized protein
Search

PPWD1

0.94	Peptidylprolyl isomerase domain and WD repeat-containing protein 1

0.72	GO:0000413	protein peptidyl-prolyl isomerization
0.37	GO:0008380	RNA splicing
0.36	GO:0006397	mRNA processing
0.35	GO:0006457	protein folding

0.72	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.33	GO:0008289	lipid binding

0.53	GO:0071013	catalytic step 2 spliceosome
0.51	GO:0016604	nuclear body
0.30	GO:0016021	integral component of membrane

0.72

GO:0003755

tr|T1EEE4|T1EEE4_HELRO
Nucleolar GTP-binding protein 1
Search

GTPBP4

0.71	Nucleolar GTP-binding protein 1

0.63	GO:0042254	ribosome biogenesis
0.41	GO:0033342	negative regulation of collagen binding
0.40	GO:0031397	negative regulation of protein ubiquitination
0.39	GO:0022408	negative regulation of cell-cell adhesion
0.39	GO:0030336	negative regulation of cell migration
0.39	GO:0008156	negative regulation of DNA replication
0.39	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
0.39	GO:0050821	protein stabilization
0.39	GO:0008285	negative regulation of cell proliferation
0.37	GO:0016072	rRNA metabolic process

0.65	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0003924	GTPase activity
0.33	GO:0003723	RNA binding

0.73	GO:0005730	nucleolus
0.39	GO:0048471	perinuclear region of cytoplasm
0.38	GO:0031965	nuclear membrane
0.37	GO:0005794	Golgi apparatus
0.36	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

tr|T1EEE5|T1EEE5_HELRO
Uncharacterized protein
Search

tr|T1EEE6|T1EEE6_HELRO
Uncharacterized protein
Search

0.59	GO:0035269	protein O-linked mannosylation
0.56	GO:0007411	axon guidance

0.57

GO:0015020

glucuronosyltransferase activity

0.52	GO:0005794	Golgi apparatus
0.30	GO:0016020	membrane

0.57

EC:2.4.1.17

GO:0015020

tr|T1EEE7|T1EEE7_HELRO
Polypeptide N-acetylgalactosaminyltransferase
Search

0.55	Polypeptide N-acetylgalactosaminyltransferase

0.72	GO:0006486	protein glycosylation
0.38	GO:0018210	peptidyl-threonine modification
0.36	GO:0033363	secretory granule organization
0.36	GO:0051047	positive regulation of secretion
0.35	GO:0001731	formation of translation preinitiation complex
0.35	GO:0006446	regulation of translational initiation
0.35	GO:0018209	peptidyl-serine modification
0.35	GO:0009312	oligosaccharide biosynthetic process
0.34	GO:0009298	GDP-mannose biosynthetic process
0.33	GO:0006351	transcription, DNA-templated

0.68	GO:0030246	carbohydrate binding
0.64	GO:0016757	transferase activity, transferring glycosyl groups
0.37	GO:0005112	Notch binding
0.36	GO:0140096	catalytic activity, acting on a protein
0.35	GO:0043022	ribosome binding
0.34	GO:0003743	translation initiation factor activity
0.34	GO:0046872	metal ion binding
0.34	GO:0004476	mannose-6-phosphate isomerase activity

0.71	GO:0000139	Golgi membrane
0.37	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0070062	extracellular exosome
0.35	GO:0016282	eukaryotic 43S preinitiation complex
0.35	GO:0033290	eukaryotic 48S preinitiation complex
0.35	GO:0005852	eukaryotic translation initiation factor 3 complex
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.64

GO:0016757

tr|T1EEE8|T1EEE8_HELRO
Uncharacterized protein
Search

NAA50

0.94	N-alpha-acetyltransferase 50, NatE catalytic subunit

0.54	GO:0071962	mitotic sister chromatid cohesion, centromeric
0.53	GO:0034087	establishment of mitotic sister chromatid cohesion
0.52	GO:0006474	N-terminal protein amino acid acetylation
0.51	GO:0016573	histone acetylation
0.34	GO:0001756	somitogenesis

0.67	GO:0008080	N-acetyltransferase activity
0.34	GO:0005515	protein binding

0.55	GO:0031415	NatA complex
0.45	GO:0005829	cytosol
0.42	GO:0005634	nucleus
0.37	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.67

EC:2.3.1

GO:0008080

tr|T1EEE9|T1EEE9_HELRO
Uncharacterized protein
Search

0.83	Beta-catenin

0.85	GO:0034333	adherens junction assembly
0.67	GO:0002159	desmosome assembly
0.61	GO:0007165	signal transduction
0.56	GO:0007155	cell adhesion
0.53	GO:0071681	cellular response to indole-3-methanol
0.52	GO:0086069	bundle of His cell to Purkinje myocyte communication
0.52	GO:0098911	regulation of ventricular cardiac muscle cell action potential
0.51	GO:0043537	negative regulation of blood vessel endothelial cell migration
0.51	GO:0086091	regulation of heart rate by cardiac conduction
0.51	GO:0001954	positive regulation of cell-matrix adhesion

0.67	GO:0045294	alpha-catenin binding
0.64	GO:0004871	signal transducer activity
0.62	GO:0045296	cadherin binding
0.50	GO:0019903	protein phosphatase binding
0.50	GO:0005198	structural molecule activity
0.48	GO:0003713	transcription coactivator activity
0.37	GO:0019901	protein kinase binding
0.35	GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
0.35	GO:0042803	protein homodimerization activity

0.66	GO:0016342	catenin complex
0.63	GO:0005913	cell-cell adherens junction
0.54	GO:0071665	gamma-catenin-TCF7L2 complex
0.51	GO:0030057	desmosome
0.51	GO:0014704	intercalated disc
0.50	GO:0030018	Z disc
0.48	GO:0005882	intermediate filament
0.45	GO:0032993	protein-DNA complex
0.44	GO:0005829	cytosol
0.38	GO:0016327	apicolateral plasma membrane

tr|T1EEF0|T1EEF0_HELRO
ATP synthase subunit d, mitochondrial
Search

0.61	ATP synthase subunit d, mitochondrial

0.70	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.70	GO:0006754	ATP biosynthetic process
0.39	GO:0099132	ATP hydrolysis coupled cation transmembrane transport

0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.39	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
0.39	GO:0019829	cation-transporting ATPase activity

0.78	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
0.43	GO:0045265	proton-transporting ATP synthase, stator stalk
0.42	GO:0043209	myelin sheath
0.39	GO:0005654	nucleoplasm

tr|T1EEF1|T1EEF1_HELRO
Uncharacterized protein
Search

tr|T1EEF2|T1EEF2_HELRO
Uncharacterized protein
Search

WDR86

0.93	WD repeat-containing protein 86

0.44	GO:0031929	TOR signaling
0.44	GO:0032008	positive regulation of TOR signaling
0.44	GO:0006468	protein phosphorylation
0.44	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
0.40	GO:0051493	regulation of cytoskeleton organization
0.39	GO:0040028	regulation of vulval development
0.39	GO:0045746	negative regulation of Notch signaling pathway
0.39	GO:0034517	ribophagy
0.39	GO:0046660	female sex differentiation
0.38	GO:0072671	mitochondria-associated ubiquitin-dependent protein catabolic process

0.46	GO:0043531	ADP binding
0.45	GO:0004534	5'-3' exoribonuclease activity
0.44	GO:0004672	protein kinase activity
0.40	GO:0005524	ATP binding
0.40	GO:0003676	nucleic acid binding
0.38	GO:0019901	protein kinase binding
0.37	GO:0043130	ubiquitin binding
0.37	GO:0042803	protein homodimerization activity
0.36	GO:0043021	ribonucleoprotein complex binding
0.36	GO:0004842	ubiquitin-protein transferase activity

0.44	GO:0031931	TORC1 complex
0.44	GO:0031932	TORC2 complex
0.43	GO:0005634	nucleus
0.39	GO:0030684	preribosome
0.38	GO:0030424	axon
0.37	GO:0043233	organelle lumen
0.37	GO:0097361	CIA complex
0.36	GO:0044446	intracellular organelle part
0.36	GO:1990391	DNA repair complex
0.35	GO:0043232	intracellular non-membrane-bounded organelle

0.45	EC:3.1.13	GO:0004534
0.36	KEGG:R03876	GO:0004842

tr|T1EEF3|T1EEF3_HELRO
Uncharacterized protein
Search

0.54	10-formyltetrahydrofolate dehydrogenase

0.82	GO:0009258	10-formyltetrahydrofolate catabolic process
0.66	GO:0006730	one-carbon metabolic process
0.53	GO:0055114	oxidation-reduction process
0.46	GO:0009058	biosynthetic process
0.41	GO:0016567	protein ubiquitination

0.82	GO:0016155	formyltetrahydrofolate dehydrogenase activity
0.69	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.68	GO:0016742	hydroxymethyl-, formyl- and related transferase activity

0.46	GO:0005737	cytoplasm
0.40	GO:0005634	nucleus

0.82	EC:1.5.1.6	GO:0016155
0.82	KEGG:R00941	GO:0016155

tr|T1EEF4|T1EEF4_HELRO
Uncharacterized protein
Search

BBS5

0.94	Bardet-Biedl syndrome 5 protein homolog

0.51	GO:0060271	cilium assembly
0.43	GO:0046907	intracellular transport
0.42	GO:0072116	pronephros formation
0.41	GO:0051877	pigment granule aggregation in cell center
0.41	GO:0032401	establishment of melanosome localization
0.41	GO:0001947	heart looping
0.40	GO:0070121	Kupffer's vesicle development
0.39	GO:0048749	compound eye development
0.39	GO:0007369	gastrulation
0.37	GO:0048741	skeletal muscle fiber development

0.52	GO:0032266	phosphatidylinositol-3-phosphate binding
0.49	GO:0001103	RNA polymerase II repressing transcription factor binding

0.84	GO:0034464	BBSome
0.52	GO:0036064	ciliary basal body
0.49	GO:0005930	axoneme
0.39	GO:0060170	ciliary membrane
0.35	GO:0031430	M band
0.35	GO:0033017	sarcoplasmic reticulum membrane
0.34	GO:0005829	cytosol
0.34	GO:0031463	Cul3-RING ubiquitin ligase complex
0.33	GO:0097546	ciliary base
0.33	GO:0097730	non-motile cilium

tr|T1EEF5|T1EEF5_HELRO
Uncharacterized protein
Search

0.70	Collagen alpha-2(I) chain

0.41	GO:0009405	pathogenesis
0.40	GO:0009653	anatomical structure morphogenesis
0.39	GO:0007275	multicellular organism development
0.38	GO:0009888	tissue development
0.38	GO:0030154	cell differentiation
0.38	GO:0010951	negative regulation of endopeptidase activity
0.37	GO:0007155	cell adhesion
0.36	GO:0120036	plasma membrane bounded cell projection organization
0.35	GO:0030198	extracellular matrix organization
0.35	GO:0042221	response to chemical

0.65	GO:0005201	extracellular matrix structural constituent
0.39	GO:0004867	serine-type endopeptidase inhibitor activity
0.37	GO:0043394	proteoglycan binding
0.37	GO:0042802	identical protein binding
0.36	GO:0008201	heparin binding
0.36	GO:0042302	structural constituent of cuticle
0.34	GO:0048407	platelet-derived growth factor binding
0.34	GO:0005178	integrin binding
0.34	GO:0002020	protease binding
0.32	GO:0030246	carbohydrate binding

0.66	GO:0005581	collagen trimer
0.43	GO:0044420	extracellular matrix component
0.42	GO:0005578	proteinaceous extracellular matrix
0.39	GO:0019867	outer membrane
0.36	GO:0005615	extracellular space
0.36	GO:0099512	supramolecular fiber
0.34	GO:1903561	extracellular vesicle
0.32	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.32

GO:0004553

tr|T1EEF6|T1EEF6_HELRO
Uncharacterized protein
Search

EXOSC7

0.76	Exosome component 7

0.64	GO:0034473	U1 snRNA 3'-end processing
0.63	GO:0071047	polyadenylation-dependent mRNA catabolic process
0.63	GO:0034476	U5 snRNA 3'-end processing
0.62	GO:0034475	U4 snRNA 3'-end processing
0.62	GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
0.62	GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process
0.62	GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.62	GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process
0.62	GO:0071028	nuclear mRNA surveillance
0.62	GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'

0.62	GO:0017091	AU-rich element binding
0.53	GO:0004527	exonuclease activity
0.39	GO:0004540	ribonuclease activity
0.35	GO:0005515	protein binding

0.72	GO:0000178	exosome (RNase complex)
0.52	GO:0031981	nuclear lumen
0.44	GO:0044444	cytoplasmic part
0.36	GO:0043232	intracellular non-membrane-bounded organelle

tr|T1EEF7|T1EEF7_HELRO
Uncharacterized protein
Search

FAH

0.46	Fumarylacetoacetate hydrolase

0.69	GO:0009072	aromatic amino acid family metabolic process
0.41	GO:0006527	arginine catabolic process
0.37	GO:0001510	RNA methylation
0.36	GO:0006396	RNA processing
0.35	GO:1902222	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process
0.34	GO:0042737	drug catabolic process
0.34	GO:1901361	organic cyclic compound catabolic process
0.34	GO:0019439	aromatic compound catabolic process
0.33	GO:0090501	RNA phosphodiester bond hydrolysis
0.33	GO:0006399	tRNA metabolic process

0.83	GO:0004334	fumarylacetoacetase activity
0.37	GO:0008173	RNA methyltransferase activity
0.35	GO:0003723	RNA binding
0.34	GO:0046872	metal ion binding
0.33	GO:0004540	ribonuclease activity
0.33	GO:0005515	protein binding
0.33	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.32	GO:0020037	heme binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.36	GO:0070062	extracellular exosome
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.83	EC:3.7.1.2	GO:0004334
0.83	KEGG:R01364	GO:0004334

tr|T1EEF8|T1EEF8_HELRO
Uncharacterized protein
Search

0.62	GO:0070544	histone H3-K36 demethylation
0.57	GO:0006303	double-strand break repair via nonhomologous end joining
0.52	GO:0032259	methylation
0.39	GO:0033184	positive regulation of histone ubiquitination
0.39	GO:0060563	neuroepithelial cell differentiation
0.38	GO:0001947	heart looping
0.38	GO:0001843	neural tube closure
0.38	GO:0035264	multicellular organism growth
0.38	GO:0001701	in utero embryonic development
0.37	GO:0043066	negative regulation of apoptotic process

0.62	GO:0051864	histone demethylase activity (H3-K36 specific)
0.61	GO:0008270	zinc ion binding
0.53	GO:0003677	DNA binding
0.52	GO:0008168	methyltransferase activity
0.35	GO:0005515	protein binding
0.34	GO:0070011	peptidase activity, acting on L-amino acid peptides
0.34	GO:0042973	glucan endo-1,3-beta-D-glucosidase activity
0.34	GO:0003972	RNA ligase (ATP) activity
0.33	GO:0052861	glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group
0.33	GO:0005234	extracellularly glutamate-gated ion channel activity

0.57	GO:0005634	nucleus
0.37	GO:0070013	intracellular organelle lumen
0.36	GO:0000785	chromatin
0.35	GO:0005618	cell wall
0.34	GO:0005576	extracellular region
0.33	GO:0045179	apical cortex
0.33	GO:0030428	cell septum
0.33	GO:0097610	cell surface furrow
0.33	GO:0005854	nascent polypeptide-associated complex
0.33	GO:0030496	midbody

0.62

EC:1.14.11.27

GO:0051864

tr|T1EEF9|T1EEF9_HELRO
Uncharacterized protein
Search

0.74	Kynurenine--oxoglutarate transaminase

0.71	GO:0097052	L-kynurenine metabolic process
0.49	GO:0006103	2-oxoglutarate metabolic process
0.49	GO:0009058	biosynthetic process
0.42	GO:0006575	cellular modified amino acid metabolic process
0.35	GO:0000398	mRNA splicing, via spliceosome
0.32	GO:0055114	oxidation-reduction process

0.76	GO:0036137	kynurenine aminotransferase activity
0.67	GO:0030170	pyridoxal phosphate binding
0.52	GO:0047804	cysteine-S-conjugate beta-lyase activity
0.47	GO:0042803	protein homodimerization activity
0.46	GO:0070548	L-glutamine aminotransferase activity
0.35	GO:0003723	RNA binding
0.33	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
0.33	GO:0046872	metal ion binding

0.41	GO:0005739	mitochondrion
0.37	GO:0044428	nuclear part
0.36	GO:0005829	cytosol
0.36	GO:0070013	intracellular organelle lumen
0.34	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

0.52

EC:4.4.1.13

GO:0047804

tr|T1EEG0|T1EEG0_HELRO
Uncharacterized protein
Search

0.44

GO:0016310

phosphorylation

0.45

GO:0016301

kinase activity

0.30

GO:0044425

membrane part

tr|T1EEG1|T1EEG1_HELRO
Uncharacterized protein
Search

0.78	Thromboxane A synthase 1 (platelet)

0.53	GO:0055114	oxidation-reduction process
0.33	GO:0007608	sensory perception of smell
0.32	GO:0035023	regulation of Rho protein signal transduction
0.32	GO:0071897	DNA biosynthetic process
0.32	GO:0006260	DNA replication
0.32	GO:0065009	regulation of molecular function

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.68	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.35	GO:0003958	NADPH-hemoprotein reductase activity
0.34	GO:0010181	FMN binding
0.32	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.32	GO:0003887	DNA-directed DNA polymerase activity
0.32	GO:0003677	DNA binding

0.34	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0031090	organelle membrane
0.30	GO:0031224	intrinsic component of membrane

0.68

GO:0016705

tr|T1EEG2|T1EEG2_HELRO
Uncharacterized protein
Search

DTWD1

0.75	DTW domain-containing protein 1

0.55	GO:0006413	translational initiation
0.51	GO:0008543	fibroblast growth factor receptor signaling pathway
0.48	GO:0010469	regulation of receptor activity

0.55	GO:0003743	translation initiation factor activity
0.51	GO:0005104	fibroblast growth factor receptor binding
0.49	GO:0008083	growth factor activity

0.44	GO:0005576	extracellular region
0.30	GO:0044425	membrane part

tr|T1EEG3|T1EEG3_HELRO
Uncharacterized protein
Search

CLCN4

0.81	Chloride voltage-gated channel 4

0.76

GO:1902476

chloride transmembrane transport

0.77	GO:0005247	voltage-gated chloride channel activity
0.43	GO:0015297	antiporter activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0046872	metal ion binding

0.43	GO:0005789	endoplasmic reticulum membrane
0.38	GO:0005887	integral component of plasma membrane
0.36	GO:0031901	early endosome membrane
0.36	GO:0031902	late endosome membrane

tr|T1EEG4|T1EEG4_HELRO
Chloride channel protein
Search

0.52	Chloride channel protein (Fragment)

0.77	GO:1902476	chloride transmembrane transport
0.46	GO:0048388	endosomal lumen acidification
0.44	GO:0003014	renal system process
0.35	GO:0097401	synaptic vesicle lumen acidification
0.35	GO:0045794	negative regulation of cell volume
0.35	GO:0051932	synaptic transmission, GABAergic
0.35	GO:0035249	synaptic transmission, glutamatergic
0.35	GO:1903428	positive regulation of reactive oxygen species biosynthetic process
0.35	GO:0045494	photoreceptor cell maintenance
0.35	GO:0006911	phagocytosis, engulfment

0.78	GO:0005247	voltage-gated chloride channel activity
0.35	GO:0072320	volume-sensitive chloride channel activity
0.35	GO:0042802	identical protein binding
0.34	GO:0030165	PDZ domain binding
0.34	GO:0046982	protein heterodimerization activity
0.33	GO:0015297	antiporter activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0046872	metal ion binding

0.43	GO:0055037	recycling endosome
0.43	GO:0005769	early endosome
0.37	GO:0045177	apical part of cell
0.36	GO:0005887	integral component of plasma membrane
0.36	GO:0005794	Golgi apparatus
0.35	GO:0060077	inhibitory synapse
0.35	GO:0042581	specific granule
0.34	GO:0043679	axon terminus
0.34	GO:0005829	cytosol
0.34	GO:0045335	phagocytic vesicle

0.32

GO:0016787

tr|T1EEG5|T1EEG5_HELRO
Uncharacterized protein
Search

0.65	GO:0016192	vesicle-mediated transport
0.42	GO:0048477	oogenesis
0.42	GO:0008283	cell proliferation
0.39	GO:0045682	regulation of epidermis development
0.38	GO:0098657	import into cell
0.37	GO:0036465	synaptic vesicle recycling
0.37	GO:0048268	clathrin coat assembly
0.37	GO:0099643	signal release from synapse
0.37	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.36	GO:0006836	neurotransmitter transport

0.52	GO:0045296	cadherin binding
0.52	GO:0030276	clathrin binding
0.36	GO:0008289	lipid binding

0.68	GO:0005794	Golgi apparatus
0.47	GO:0005654	nucleoplasm
0.42	GO:0031410	cytoplasmic vesicle
0.39	GO:0031984	organelle subcompartment
0.37	GO:0045095	keratin filament
0.36	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0098793	presynapse
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEG6|T1EEG6_HELRO
Uncharacterized protein
Search

CDK9

0.89	Cell division protein kinase 9

0.63	GO:0006468	protein phosphorylation
0.45	GO:1903839	positive regulation of mRNA 3'-UTR binding
0.45	GO:0033129	positive regulation of histone phosphorylation
0.44	GO:2001168	positive regulation of histone H2B ubiquitination
0.44	GO:0061026	cardiac muscle tissue regeneration
0.44	GO:0051726	regulation of cell cycle
0.44	GO:0045944	positive regulation of transcription by RNA polymerase II
0.43	GO:0006368	transcription elongation from RNA polymerase II promoter
0.43	GO:1900364	negative regulation of mRNA polyadenylation
0.43	GO:0060043	regulation of cardiac muscle cell proliferation

0.67	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0097472	cyclin-dependent protein kinase activity
0.45	GO:0044212	transcription regulatory region DNA binding
0.44	GO:0030332	cyclin binding
0.44	GO:0097322	7SK snRNA binding
0.44	GO:0008134	transcription factor binding

0.49	GO:0008024	cyclin/CDK positive transcription elongation factor complex
0.42	GO:0016605	PML body
0.41	GO:0036464	cytoplasmic ribonucleoprotein granule
0.41	GO:0005694	chromosome
0.30	GO:0016020	membrane

0.67

GO:0004674

tr|T1EEG7|T1EEG7_HELRO
Uncharacterized protein
Search

GOLGA7

0.91	Golgi complex-associated protein of 16 kDa

0.86	GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
0.85	GO:0018345	protein palmitoylation
0.84	GO:0043001	Golgi to plasma membrane protein transport
0.74	GO:0050821	protein stabilization
0.62	GO:0006612	protein targeting to membrane
0.40	GO:0043312	neutrophil degranulation
0.36	GO:0006260	DNA replication

0.66	GO:0019706	protein-cysteine S-palmitoyltransferase activity
0.36	GO:0005515	protein binding

0.85	GO:0002178	palmitoyltransferase complex
0.78	GO:0005795	Golgi stack
0.77	GO:0031228	intrinsic component of Golgi membrane
0.42	GO:0070062	extracellular exosome
0.41	GO:1904724	tertiary granule lumen
0.36	GO:0005634	nucleus

0.66

GO:0019706

tr|T1EEG8|T1EEG8_HELRO
Uncharacterized protein
Search

CLPTM1L

0.83	Cleft lip and palate transmembrane protein 1

0.78

GO:0006915

apoptotic process

0.30

GO:0044425

membrane part

tr|T1EEG9|T1EEG9_HELRO
Uncharacterized protein
Search

0.66	Inward rectifier potassium channel

0.78	GO:0034765	regulation of ion transmembrane transport
0.71	GO:0006813	potassium ion transport
0.61	GO:0098655	cation transmembrane transport
0.40	GO:0090099	negative regulation of decapentaplegic signaling pathway
0.39	GO:0042391	regulation of membrane potential
0.38	GO:0035220	wing disc development
0.37	GO:0098660	inorganic ion transmembrane transport
0.36	GO:0086026	atrial cardiac muscle cell to AV node cell signaling
0.35	GO:0086003	cardiac muscle cell contraction
0.35	GO:0086091	regulation of heart rate by cardiac conduction

0.84	GO:0005242	inward rectifier potassium channel activity
0.36	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization

0.38	GO:0005887	integral component of plasma membrane
0.35	GO:0034705	potassium channel complex

tr|T1EEH0|T1EEH0_HELRO
Uncharacterized protein
Search

0.60	Matrix metalloproteinase-9

0.61	GO:0006508	proteolysis
0.51	GO:0006954	inflammatory response
0.47	GO:0060022	hard palate development
0.40	GO:0048513	animal organ development
0.40	GO:0042756	drinking behavior
0.39	GO:0010727	negative regulation of hydrogen peroxide metabolic process
0.38	GO:0072001	renal system development
0.38	GO:0032461	positive regulation of protein oligomerization
0.38	GO:0030728	ovulation
0.38	GO:0051591	response to cAMP

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.39	GO:0016758	transferase activity, transferring hexosyl groups
0.35	GO:0004252	serine-type endopeptidase activity
0.34	GO:0016504	peptidase activator activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0003676	nucleic acid binding

0.74	GO:0031012	extracellular matrix
0.40	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0005615	extracellular space
0.37	GO:0005886	plasma membrane
0.36	GO:0031225	anchored component of membrane
0.34	GO:0035579	specific granule membrane
0.33	GO:0009986	cell surface
0.30	GO:0016021	integral component of membrane

0.70

GO:0004222

tr|T1EEH1|T1EEH1_HELRO
Uncharacterized protein
Search

PUF60

0.40	Poly(U)-binding-splicing factor half pint

0.40	GO:0007282	cystoblast division
0.39	GO:0000380	alternative mRNA splicing, via spliceosome
0.39	GO:0043484	regulation of RNA splicing
0.38	GO:0006376	mRNA splice site selection
0.38	GO:0045926	negative regulation of growth
0.38	GO:0001558	regulation of cell growth
0.38	GO:0008285	negative regulation of cell proliferation
0.37	GO:0050684	regulation of mRNA processing
0.36	GO:0006915	apoptotic process
0.34	GO:0048477	oogenesis

0.59	GO:0003723	RNA binding
0.40	GO:0045296	cadherin binding
0.39	GO:0042802	identical protein binding
0.33	GO:0003677	DNA binding
0.32	GO:0016491	oxidoreductase activity

0.41	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex
0.38	GO:0030054	cell junction
0.37	GO:0031981	nuclear lumen
0.34	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.32

GO:0016491

tr|T1EEH2|T1EEH2_HELRO
Uncharacterized protein
Search

TSR1

0.78	Pre-rrna-processing protein tsr1 log

0.66	GO:0042254	ribosome biogenesis
0.44	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.43	GO:0016072	rRNA metabolic process
0.42	GO:0034470	ncRNA processing
0.35	GO:0031123	RNA 3'-end processing
0.34	GO:0006606	protein import into nucleus
0.33	GO:0000723	telomere maintenance
0.32	GO:0032392	DNA geometric change
0.32	GO:0006310	DNA recombination
0.32	GO:0006281	DNA repair

0.49	GO:0034511	U3 snoRNA binding
0.43	GO:0003924	GTPase activity
0.42	GO:0032550	purine ribonucleoside binding
0.42	GO:0019001	guanyl nucleotide binding
0.38	GO:0032555	purine ribonucleotide binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0043021	ribonucleoprotein complex binding
0.34	GO:0061608	nuclear import signal receptor activity
0.32	GO:0003678	DNA helicase activity
0.32	GO:0003677	DNA binding

0.60	GO:0005634	nucleus
0.48	GO:0030688	preribosome, small subunit precursor
0.36	GO:0031974	membrane-enclosed lumen
0.35	GO:0043232	intracellular non-membrane-bounded organelle
0.35	GO:0044446	intracellular organelle part
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEH3|T1EEH3_HELRO
Uncharacterized protein
Search

0.81	Putative negative regulation of neuron apoptotic process

0.49	GO:0006457	protein folding
0.45	GO:0052033	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response
0.44	GO:0099643	signal release from synapse
0.44	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.43	GO:0008340	determination of adult lifespan
0.42	GO:0006836	neurotransmitter transport
0.42	GO:0009408	response to heat
0.41	GO:0001505	regulation of neurotransmitter levels
0.40	GO:0051649	establishment of localization in cell
0.39	GO:0040011	locomotion

0.50	GO:0051082	unfolded protein binding
0.43	GO:0031072	heat shock protein binding
0.38	GO:0008270	zinc ion binding
0.37	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005230	extracellular ligand-gated ion channel activity
0.35	GO:0003743	translation initiation factor activity
0.35	GO:0004252	serine-type endopeptidase activity
0.34	GO:0051787	misfolded protein binding

0.43	GO:0005788	endoplasmic reticulum lumen
0.43	GO:0098793	presynapse
0.37	GO:0005886	plasma membrane
0.37	GO:0005829	cytosol
0.36	GO:0044306	neuron projection terminus
0.36	GO:0033267	axon part
0.36	GO:0070382	exocytic vesicle
0.33	GO:0005634	nucleus
0.33	GO:0015935	small ribosomal subunit
0.30	GO:0016021	integral component of membrane

0.35

GO:0004252

tr|T1EEH4|T1EEH4_HELRO
Uncharacterized protein
Search

0.47	GO:0017148	negative regulation of translation
0.47	GO:0042273	ribosomal large subunit biogenesis

0.59	GO:0003723	RNA binding
0.52	GO:0000900	translation repressor activity, nucleic acid binding

0.48	GO:0030687	preribosome, large subunit precursor
0.44	GO:0015934	large ribosomal subunit
0.40	GO:0005730	nucleolus

tr|T1EEH5|T1EEH5_HELRO
Uncharacterized protein
Search

TSN

0.44	Secreted salivary gland peptide

0.55	GO:0016070	RNA metabolic process
0.36	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.34	GO:0016246	RNA interference
0.34	GO:0071359	cellular response to dsRNA
0.33	GO:0006310	DNA recombination
0.32	GO:0010467	gene expression

0.74	GO:0003697	single-stranded DNA binding
0.65	GO:0043565	sequence-specific DNA binding
0.59	GO:0003723	RNA binding
0.48	GO:0042802	identical protein binding
0.38	GO:0032403	protein complex binding
0.37	GO:0004519	endonuclease activity

0.43	GO:0005634	nucleus
0.37	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EEH6|T1EEH6_HELRO
Uncharacterized protein
Search

0.43	Potassium voltage-gated channel protein Shab

0.78	GO:0051260	protein homooligomerization
0.78	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.37	GO:0072659	protein localization to plasma membrane
0.35	GO:0060025	regulation of synaptic activity
0.35	GO:0045938	positive regulation of circadian sleep/wake cycle, sleep
0.35	GO:0008345	larval locomotory behavior
0.34	GO:0021591	ventricular system development
0.34	GO:0090504	epiboly
0.34	GO:0001508	action potential

0.78	GO:0005249	voltage-gated potassium channel activity
0.36	GO:0046982	protein heterodimerization activity
0.34	GO:0042162	telomeric DNA binding
0.34	GO:0042803	protein homodimerization activity

0.78	GO:0008076	voltage-gated potassium channel complex
0.38	GO:0032809	neuronal cell body membrane
0.37	GO:0043204	perikaryon
0.36	GO:0030425	dendrite
0.35	GO:0044214	spanning component of plasma membrane

tr|T1EEH7|T1EEH7_HELRO
Uncharacterized protein
Search

0.32	Dihydropyrimidinase

0.81	GO:0051491	positive regulation of filopodium assembly
0.81	GO:0048678	response to axon injury
0.77	GO:0051017	actin filament bundle assembly
0.75	GO:0010975	regulation of neuron projection development
0.73	GO:0030334	regulation of cell migration
0.47	GO:0051764	actin crosslink formation
0.45	GO:0045665	negative regulation of neuron differentiation
0.45	GO:0031345	negative regulation of cell projection organization
0.45	GO:2000146	negative regulation of cell motility
0.45	GO:0045666	positive regulation of neuron differentiation

0.65	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
0.53	GO:0031005	filamin binding
0.48	GO:0035374	chondroitin sulfate binding
0.44	GO:0017124	SH3 domain binding
0.40	GO:0051219	phosphoprotein binding
0.37	GO:0002059	thymine binding
0.37	GO:0002058	uracil binding
0.35	GO:0016597	amino acid binding
0.34	GO:0008270	zinc ion binding
0.33	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters

0.48	GO:0005737	cytoplasm
0.47	GO:0030426	growth cone
0.46	GO:0031941	filamentous actin
0.45	GO:0030027	lamellipodium
0.44	GO:0044297	cell body
0.43	GO:0005615	extracellular space
0.42	GO:0031982	vesicle
0.41	GO:0012505	endomembrane system
0.34	GO:0043230	extracellular organelle
0.32	GO:0005634	nucleus

0.65

EC:3.5

GO:0016810

tr|T1EEH8|T1EEH8_HELRO
Uncharacterized protein
Search

tr|T1EEH9|T1EEH9_HELRO
Uncharacterized protein
Search

0.58	GO:0048024	regulation of mRNA splicing, via spliceosome
0.47	GO:0051259	protein oligomerization
0.37	GO:0006397	mRNA processing
0.36	GO:1903506	regulation of nucleic acid-templated transcription
0.36	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0046833	positive regulation of RNA export from nucleus
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:0010628	positive regulation of gene expression
0.35	GO:0051173	positive regulation of nitrogen compound metabolic process
0.35	GO:0031325	positive regulation of cellular metabolic process

0.59	GO:0003723	RNA binding
0.55	GO:0019904	protein domain specific binding
0.54	GO:0042802	identical protein binding
0.45	GO:0046982	protein heterodimerization activity
0.35	GO:0005070	SH3/SH2 adaptor activity

0.47	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

tr|T1EEI0|T1EEI0_HELRO
Uncharacterized protein
Search

0.10	Splicing factor 3A subunit 1

0.63	GO:0006396	RNA processing
0.45	GO:0016071	mRNA metabolic process
0.43	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.40	GO:0022618	ribonucleoprotein complex assembly
0.39	GO:0007283	spermatogenesis

0.59	GO:0003723	RNA binding
0.32	GO:0005515	protein binding

0.50	GO:0005686	U2 snRNP
0.49	GO:0071013	catalytic step 2 spliceosome
0.49	GO:0005684	U2-type spliceosomal complex
0.49	GO:0016607	nuclear speck
0.42	GO:0071010	prespliceosome
0.30	GO:0016020	membrane

tr|T1EEI1|T1EEI1_HELRO
Uncharacterized protein
Search

PIGN

0.93	Phosphatidylinositol glycan anchor biosynthesis class N

0.78

GO:0006506

GPI anchor biosynthetic process

0.84	GO:0051377	mannose-ethanolamine phosphotransferase activity
0.36	GO:0008484	sulfuric ester hydrolase activity

0.72	GO:0005789	endoplasmic reticulum membrane
0.57	GO:0005829	cytosol
0.48	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.36

EC:3.1.6

GO:0008484

tr|T1EEI2|T1EEI2_HELRO
Uncharacterized protein
Search

UBA5

0.86	Ubiquitin like modifier activating enzyme 5

0.56	GO:0071569	protein ufmylation
0.51	GO:0033146	regulation of intracellular estrogen receptor signaling pathway
0.48	GO:0034976	response to endoplasmic reticulum stress

0.76	GO:0008641	ubiquitin-like modifier activating enzyme activity
0.37	GO:0030554	adenyl nucleotide binding
0.37	GO:0097367	carbohydrate derivative binding
0.37	GO:0008144	drug binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.44	GO:0005829	cytosol
0.41	GO:0019008	molybdopterin synthase complex
0.40	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEI3|T1EEI3_HELRO
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
Search

0.66	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B

0.79	GO:0043666	regulation of phosphoprotein phosphatase activity
0.47	GO:0045201	maintenance of neuroblast polarity
0.46	GO:0007091	metaphase/anaphase transition of mitotic cell cycle
0.45	GO:0007406	negative regulation of neuroblast proliferation
0.45	GO:0007447	imaginal disc pattern formation
0.44	GO:0001700	embryonic development via the syncytial blastoderm
0.44	GO:0007099	centriole replication
0.44	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.43	GO:0030071	regulation of mitotic metaphase/anaphase transition
0.43	GO:0050821	protein stabilization

0.80	GO:0019888	protein phosphatase regulator activity
0.44	GO:0004722	protein serine/threonine phosphatase activity
0.33	GO:0005515	protein binding

0.81	GO:0000159	protein phosphatase type 2A complex
0.38	GO:0005634	nucleus
0.37	GO:0005829	cytosol
0.33	GO:0072686	mitotic spindle
0.32	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

tr|T1EEI4|T1EEI4_HELRO
Uncharacterized protein
Search

MTO1

0.49	Glucose-inhibited division protein A

0.77	GO:0002098	tRNA wobble uridine modification
0.46	GO:0070900	mitochondrial tRNA modification
0.41	GO:0006904	vesicle docking involved in exocytosis
0.38	GO:0030488	tRNA methylation
0.33	GO:0005975	carbohydrate metabolic process
0.32	GO:0006281	DNA repair

0.66	GO:0050660	flavin adenine dinucleotide binding
0.34	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives
0.33	GO:0008081	phosphoric diester hydrolase activity

0.39	GO:0005739	mitochondrion
0.32	GO:0005634	nucleus

0.34

EC:5.1.3

GO:0016857

tr|T1EEI5|T1EEI5_HELRO
Uncharacterized protein
Search

0.42	Guanylate cyclase

0.80	GO:0006182	cGMP biosynthetic process
0.62	GO:0006468	protein phosphorylation
0.62	GO:0035556	intracellular signal transduction
0.58	GO:0007168	receptor guanylyl cyclase signaling pathway
0.50	GO:1900194	negative regulation of oocyte maturation
0.50	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus
0.48	GO:0051447	negative regulation of meiotic cell cycle
0.47	GO:0060348	bone development
0.43	GO:0022414	reproductive process
0.39	GO:0042417	dopamine metabolic process

0.80	GO:0004383	guanylate cyclase activity
0.63	GO:0004672	protein kinase activity
0.59	GO:0016941	natriuretic peptide receptor activity
0.55	GO:0017046	peptide hormone binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0008144	drug binding
0.47	GO:0004016	adenylate cyclase activity
0.44	GO:0042802	identical protein binding

0.50	GO:0008074	guanylate cyclase complex, soluble
0.44	GO:0043235	receptor complex
0.42	GO:0005887	integral component of plasma membrane
0.32	GO:0005634	nucleus
0.32	GO:0009925	basal plasma membrane
0.32	GO:0001725	stress fiber
0.32	GO:0005902	microvillus
0.32	GO:0005884	actin filament
0.32	GO:0016324	apical plasma membrane
0.32	GO:0098857	membrane microdomain

0.80

GO:0004383

tr|T1EEI6|T1EEI6_HELRO
Uncharacterized protein
Search

0.46	GO:0045467	R7 cell development
0.46	GO:0008103	oocyte microtubule cytoskeleton polarization
0.46	GO:0045451	pole plasm oskar mRNA localization
0.45	GO:0007293	germarium-derived egg chamber formation
0.44	GO:0016192	vesicle-mediated transport
0.44	GO:0050832	defense response to fungus
0.43	GO:0007411	axon guidance
0.43	GO:0060078	regulation of postsynaptic membrane potential
0.43	GO:0007602	phototransduction
0.42	GO:0016482	cytosolic transport

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.38	GO:0031489	myosin V binding
0.36	GO:0019904	protein domain specific binding
0.34	GO:0051117	ATPase binding
0.34	GO:0001671	ATPase activator activity
0.34	GO:0003779	actin binding

0.46	GO:0005794	Golgi apparatus
0.42	GO:0031410	cytoplasmic vesicle
0.39	GO:0005829	cytosol
0.38	GO:0031984	organelle subcompartment
0.37	GO:0098588	bounding membrane of organelle
0.36	GO:0070062	extracellular exosome
0.34	GO:0043204	perikaryon
0.34	GO:0012506	vesicle membrane
0.34	GO:0045202	synapse
0.34	GO:0030054	cell junction

tr|T1EEI7|T1EEI7_HELRO
Uncharacterized protein
Search

JANA

0.49	Sex-regulated protein janus-A

0.73	GO:0035971	peptidyl-histidine dephosphorylation
0.60	GO:0007548	sex differentiation
0.49	GO:2000984	negative regulation of ATP citrate synthase activity
0.48	GO:0050860	negative regulation of T cell receptor signaling pathway
0.47	GO:0051350	negative regulation of lyase activity
0.47	GO:2000249	regulation of actin cytoskeleton reorganization
0.46	GO:0030154	cell differentiation
0.45	GO:2000147	positive regulation of cell motility
0.43	GO:0032259	methylation
0.42	GO:0043043	peptide biosynthetic process

0.65	GO:0101006	protein histidine phosphatase activity
0.48	GO:0019855	calcium channel inhibitor activity
0.46	GO:0044325	ion channel binding
0.44	GO:0008168	methyltransferase activity

0.57	GO:0005829	cytosol
0.38	GO:0008541	proteasome regulatory particle, lid subcomplex
0.30	GO:0016021	integral component of membrane

0.44

GO:0008168

tr|T1EEI8|T1EEI8_HELRO
Uncharacterized protein
Search

0.53	GO:0055114	oxidation-reduction process
0.37	GO:0019373	epoxygenase P450 pathway
0.36	GO:0009410	response to xenobiotic stimulus
0.35	GO:0043390	aflatoxin B1 metabolic process
0.34	GO:0044550	secondary metabolite biosynthetic process
0.33	GO:0070887	cellular response to chemical stimulus

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.65	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.34	GO:0019825	oxygen binding
0.34	GO:0016829	lyase activity

0.34	GO:0005788	endoplasmic reticulum lumen
0.34	GO:0009986	cell surface
0.33	GO:0071203	WASH complex
0.30	GO:0031224	intrinsic component of membrane

0.68

GO:0016705

tr|T1EEI9|T1EEI9_HELRO
Uncharacterized protein
Search

SPTLC1

0.88	Serine palmitoyltransferase subunit I

0.52	GO:1904502	regulation of lipophagy
0.51	GO:0046513	ceramide biosynthetic process
0.50	GO:0016239	positive regulation of macroautophagy
0.48	GO:0046511	sphinganine biosynthetic process
0.47	GO:0006686	sphingomyelin biosynthetic process
0.47	GO:0046512	sphingosine biosynthetic process
0.36	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
0.33	GO:0042254	ribosome biogenesis

0.67	GO:0030170	pyridoxal phosphate binding
0.52	GO:0004758	serine C-palmitoyltransferase activity
0.34	GO:0005515	protein binding
0.33	GO:0016874	ligase activity
0.33	GO:0008483	transaminase activity

0.52	GO:0035339	SPOTS complex
0.30	GO:0016021	integral component of membrane

0.52	EC:2.3.1.50	GO:0004758
0.52	KEGG:R01281	GO:0004758

tr|T1EEJ0|T1EEJ0_HELRO
Calcium-transporting ATPase
Search

ATP2C1

0.54	Calcium-transporting ATPase

0.77	GO:0070588	calcium ion transmembrane transport
0.69	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.50	GO:0006874	cellular calcium ion homeostasis
0.47	GO:0032472	Golgi calcium ion transport
0.46	GO:0042044	fluid transport
0.46	GO:0019722	calcium-mediated signaling
0.46	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
0.45	GO:0051235	maintenance of location
0.44	GO:0008544	epidermis development
0.43	GO:0031532	actin cytoskeleton reorganization

0.80	GO:0005388	calcium-transporting ATPase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0015410	manganese-transporting ATPase activity
0.36	GO:0030145	manganese ion binding
0.35	GO:0005509	calcium ion binding
0.35	GO:0004871	signal transducer activity

0.47	GO:0005794	Golgi apparatus
0.44	GO:0005777	peroxisome
0.42	GO:0005783	endoplasmic reticulum
0.41	GO:0098588	bounding membrane of organelle
0.40	GO:0031984	organelle subcompartment
0.34	GO:0030141	secretory granule
0.34	GO:0030133	transport vesicle
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.80

EC:3.6.3.8

GO:0005388

tr|T1EEJ1|T1EEJ1_HELRO
Uncharacterized protein
Search

0.55	GO:2001141	regulation of RNA biosynthetic process
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.37	GO:0090336	positive regulation of brown fat cell differentiation
0.37	GO:0050872	white fat cell differentiation
0.36	GO:0043586	tongue development
0.36	GO:0050873	brown fat cell differentiation
0.36	GO:0043457	regulation of cellular respiration
0.36	GO:0035019	somatic stem cell population maintenance
0.36	GO:0009966	regulation of signal transduction

0.51	GO:0003676	nucleic acid binding
0.36	GO:0033613	activating transcription factor binding
0.36	GO:0046332	SMAD binding
0.35	GO:0003713	transcription coactivator activity
0.35	GO:0005089	Rho guanyl-nucleotide exchange factor activity

0.36	GO:0016235	aggresome
0.36	GO:0017053	transcriptional repressor complex
0.34	GO:0005654	nucleoplasm
0.34	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEJ2|T1EEJ2_HELRO
Uncharacterized protein
Search

IQGAP1

0.90	IQ motif containing GTPase activating protein 1

0.75	GO:0043087	regulation of GTPase activity
0.62	GO:0071364	cellular response to epidermal growth factor stimulus
0.61	GO:0071277	cellular response to calcium ion
0.61	GO:0007173	epidermal growth factor receptor signaling pathway
0.60	GO:1990138	neuron projection extension
0.60	GO:0071902	positive regulation of protein serine/threonine kinase activity
0.57	GO:0036120	cellular response to platelet-derived growth factor stimulus
0.56	GO:0048008	platelet-derived growth factor receptor signaling pathway
0.55	GO:0007346	regulation of mitotic cell cycle
0.54	GO:0008543	fibroblast growth factor receptor signaling pathway

0.63	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.62	GO:0044548	S100 protein binding
0.61	GO:0005516	calmodulin binding
0.60	GO:0043539	protein serine/threonine kinase activator activity
0.59	GO:0019903	protein phosphatase binding
0.58	GO:0045296	cadherin binding
0.57	GO:0048365	Rac GTPase binding
0.56	GO:0019901	protein kinase binding
0.55	GO:0019904	protein domain specific binding
0.47	GO:0070856	myosin VI light chain binding

0.59	GO:0031252	cell leading edge
0.59	GO:0030496	midbody
0.59	GO:0016328	lateral plasma membrane
0.57	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.57	GO:0036464	cytoplasmic ribonucleoprotein granule
0.56	GO:0120025	plasma membrane bounded cell projection
0.55	GO:0099513	polymeric cytoskeletal fiber
0.54	GO:0005911	cell-cell junction
0.53	GO:0015630	microtubule cytoskeleton
0.52	GO:0097458	neuron part

tr|T1EEJ3|T1EEJ3_HELRO
Cytochrome c oxidase subunit 6A, mitochondrial
Search

COX6A2

0.81	Cytochrome c oxidase subunit VIa polypeptide 1

0.63	GO:1902600	hydrogen ion transmembrane transport
0.61	GO:0022900	electron transport chain
0.43	GO:0050790	regulation of catalytic activity
0.42	GO:0006119	oxidative phosphorylation
0.42	GO:0009060	aerobic respiration

0.65	GO:0015002	heme-copper terminal oxidase activity
0.65	GO:0016675	oxidoreductase activity, acting on a heme group of donors
0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.62	GO:0009055	electron transfer activity
0.44	GO:0030234	enzyme regulator activity

0.84	GO:0005751	mitochondrial respiratory chain complex IV
0.35	GO:0043209	myelin sheath
0.30	GO:0016021	integral component of membrane

0.65

EC:1.9

GO:0016675

tr|T1EEJ4|T1EEJ4_HELRO
Uncharacterized protein
Search

0.44	cAMP-dependent protein kinase type II-alpha regulatory subunit

0.75	GO:0045859	regulation of protein kinase activity
0.50	GO:0016310	phosphorylation
0.46	GO:0048148	behavioral response to cocaine
0.46	GO:0048149	behavioral response to ethanol
0.46	GO:0045475	locomotor rhythm
0.44	GO:0007411	axon guidance
0.38	GO:0036211	protein modification process
0.37	GO:0033673	negative regulation of kinase activity
0.37	GO:0044267	cellular protein metabolic process
0.36	GO:0001933	negative regulation of protein phosphorylation

0.84	GO:0008603	cAMP-dependent protein kinase regulator activity
0.83	GO:0030552	cAMP binding
0.52	GO:0016301	kinase activity
0.39	GO:0060089	molecular transducer activity
0.38	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.38	GO:0034236	protein kinase A catalytic subunit binding
0.38	GO:0004862	cAMP-dependent protein kinase inhibitor activity
0.38	GO:0140096	catalytic activity, acting on a protein
0.37	GO:0031625	ubiquitin protein ligase binding
0.36	GO:0019904	protein domain specific binding

0.83	GO:0005952	cAMP-dependent protein kinase complex
0.38	GO:0031588	nucleotide-activated protein kinase complex
0.37	GO:0044853	plasma membrane raft
0.37	GO:0005930	axoneme
0.37	GO:0005813	centrosome
0.34	GO:0045211	postsynaptic membrane
0.34	GO:0030054	cell junction
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.38

GO:0016773

tr|T1EEJ5|T1EEJ5_HELRO
Uncharacterized protein
Search

0.58	Monoglyceride lipase

0.55	GO:0009966	regulation of signal transduction
0.51	GO:0006629	lipid metabolic process
0.45	GO:0051930	regulation of sensory perception of pain
0.44	GO:0006690	icosanoid metabolic process
0.43	GO:0050727	regulation of inflammatory response
0.42	GO:0006954	inflammatory response
0.40	GO:0072330	monocarboxylic acid biosynthetic process
0.38	GO:0044248	cellular catabolic process
0.38	GO:1901575	organic substance catabolic process

0.68	GO:0047372	acylglycerol lipase activity
0.43	GO:0004622	lysophospholipase activity
0.41	GO:0042803	protein homodimerization activity

0.66	GO:0005654	nucleoplasm
0.41	GO:0019898	extrinsic component of membrane
0.40	GO:0005789	endoplasmic reticulum membrane
0.40	GO:0005829	cytosol
0.37	GO:0005886	plasma membrane

0.68

EC:3.1.1.23

GO:0047372

tr|T1EEJ6|T1EEJ6_HELRO
Uncharacterized protein
Search

MTMR9

0.95	Myotubularin-related protein 9

0.86	GO:0060304	regulation of phosphatidylinositol dephosphorylation
0.85	GO:0010922	positive regulation of phosphatase activity
0.79	GO:0050821	protein stabilization
0.74	GO:0010507	negative regulation of autophagy
0.39	GO:0006661	phosphatidylinositol biosynthetic process
0.37	GO:0016311	dephosphorylation
0.36	GO:0032259	methylation
0.34	GO:0055114	oxidation-reduction process

0.83	GO:0019903	protein phosphatase binding
0.69	GO:0030234	enzyme regulator activity
0.41	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
0.41	GO:0004438	phosphatidylinositol-3-phosphatase activity
0.39	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
0.36	GO:0008168	methyltransferase activity

0.59	GO:0043234	protein complex
0.49	GO:0005737	cytoplasm

0.41

EC:3.1.3

GO:0052629

tr|T1EEJ7|T1EEJ7_HELRO
Uncharacterized protein
Search

ZFYVE1

0.94	Zinc finger FYVE domain-containing protein 1

0.44	GO:0010923	negative regulation of phosphatase activity
0.43	GO:0016236	macroautophagy
0.43	GO:0009267	cellular response to starvation

0.54	GO:0046872	metal ion binding
0.46	GO:0005545	1-phosphatidylinositol binding
0.46	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
0.45	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.43	GO:0003924	GTPase activity
0.42	GO:0032550	purine ribonucleoside binding
0.42	GO:0019001	guanyl nucleotide binding
0.38	GO:0032555	purine ribonucleotide binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0003676	nucleic acid binding

0.47	GO:0097629	extrinsic component of omegasome membrane
0.45	GO:0005795	Golgi stack
0.45	GO:0048471	perinuclear region of cytoplasm
0.44	GO:0005776	autophagosome
0.44	GO:0044233	ER-mitochondrion membrane contact site
0.44	GO:0000407	phagophore assembly site
0.42	GO:0005783	endoplasmic reticulum

tr|T1EEJ8|T1EEJ8_HELRO
Uncharacterized protein
Search

DDX4

0.44	DEAD box RNA helicase Vasa

0.45	GO:0030317	flagellated sperm motility
0.43	GO:0031047	gene silencing by RNA
0.41	GO:0010501	RNA secondary structure unwinding
0.41	GO:0002183	cytoplasmic translational initiation
0.40	GO:1990511	piRNA biosynthetic process
0.40	GO:0043046	DNA methylation involved in gamete generation
0.40	GO:0010529	negative regulation of transposition
0.40	GO:0007141	male meiosis I
0.38	GO:0007283	spermatogenesis
0.37	GO:0007275	multicellular organism development

0.65	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.43	GO:0008270	zinc ion binding
0.40	GO:0008186	RNA-dependent ATPase activity
0.37	GO:0140098	catalytic activity, acting on RNA

0.45	GO:0043186	P granule
0.41	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0005730	nucleolus
0.38	GO:0033391	chromatoid body
0.35	GO:0032019	mitochondrial cloud
0.34	GO:0005635	nuclear envelope
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEJ9|T1EEJ9_HELRO
Uncharacterized protein
Search

BXLB

0.32	Periplasmic beta-glucosidase

0.60	GO:0005975	carbohydrate metabolic process
0.38	GO:0000226	microtubule cytoskeleton organization
0.32	GO:0009057	macromolecule catabolic process
0.32	GO:0044248	cellular catabolic process
0.31	GO:0044260	cellular macromolecule metabolic process

0.66

GO:0004553

hydrolase activity, hydrolyzing O-glycosyl compounds

0.37

GO:0015630

microtubule cytoskeleton

0.66

GO:0004553

tr|T1EEK0|T1EEK0_HELRO
Uncharacterized protein
Search

UBE3A

0.81	Ubiquitin protein ligase E3A

0.73	GO:0016567	protein ubiquitination
0.64	GO:0006511	ubiquitin-dependent protein catabolic process
0.49	GO:0035037	sperm entry
0.48	GO:0050847	progesterone receptor signaling pathway
0.47	GO:0048511	rhythmic process
0.47	GO:0060736	prostate gland growth
0.47	GO:0032570	response to progesterone
0.47	GO:0030521	androgen receptor signaling pathway
0.46	GO:2000058	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.46	GO:0042752	regulation of circadian rhythm

0.74	GO:0004842	ubiquitin-protein transferase activity
0.67	GO:0061659	ubiquitin-like protein ligase activity
0.53	GO:0016874	ligase activity
0.44	GO:0003713	transcription coactivator activity
0.34	GO:0005515	protein binding
0.33	GO:0046872	metal ion binding
0.32	GO:1901265	nucleoside phosphate binding
0.32	GO:0036094	small molecule binding

0.41	GO:0005829	cytosol
0.39	GO:0005634	nucleus
0.35	GO:1905369	endopeptidase complex
0.33	GO:0043234	protein complex
0.32	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

0.53	EC:6	GO:0016874
0.74	KEGG:R03876	GO:0004842

tr|T1EEK1|T1EEK1_HELRO
Uncharacterized protein
Search

NARS

0.67	Asparaginyl-tRNA synthetase

0.80	GO:0006421	asparaginyl-tRNA aminoacylation
0.36	GO:0006260	DNA replication
0.35	GO:0006281	DNA repair
0.34	GO:0006783	heme biosynthetic process
0.34	GO:0042357	thiamine diphosphate metabolic process
0.33	GO:0006772	thiamine metabolic process
0.33	GO:0032392	DNA geometric change
0.33	GO:0072528	pyrimidine-containing compound biosynthetic process
0.33	GO:0006310	DNA recombination
0.33	GO:0044272	sulfur compound biosynthetic process

0.80	GO:0004816	asparagine-tRNA ligase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.37	GO:0017108	5'-flap endonuclease activity
0.35	GO:0004325	ferrochelatase activity
0.34	GO:0043140	ATP-dependent 3'-5' DNA helicase activity
0.34	GO:0004788	thiamine diphosphokinase activity
0.33	GO:1901681	sulfur compound binding

0.48	GO:0005737	cytoplasm
0.38	GO:0043231	intracellular membrane-bounded organelle
0.37	GO:0070062	extracellular exosome
0.35	GO:0044427	chromosomal part
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0043234	protein complex

0.80	EC:6.1.1.22	GO:0004816
0.80	KEGG:R03648	GO:0004816

tr|T1EEK2|T1EEK2_HELRO
Uncharacterized protein
Search

KCNL-2

0.78	Small conductance calcium-activated potassium channel protein 1

0.73	GO:0071805	potassium ion transmembrane transport
0.41	GO:0022900	electron transport chain
0.40	GO:1901046	positive regulation of oviposition
0.34	GO:0016311	dephosphorylation
0.33	GO:0007165	signal transduction
0.33	GO:0005975	carbohydrate metabolic process

0.85	GO:0016286	small conductance calcium-activated potassium channel activity
0.79	GO:0005516	calmodulin binding
0.42	GO:0020037	heme binding
0.41	GO:0009055	electron transfer activity
0.39	GO:0046872	metal ion binding
0.38	GO:0005249	voltage-gated potassium channel activity
0.35	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity

0.39	GO:0097458	neuron part
0.38	GO:0008076	voltage-gated potassium channel complex
0.37	GO:0120025	plasma membrane bounded cell projection
0.36	GO:0044297	cell body

0.35

EC:3.1.3.11

GO:0042132

tr|T1EEK3|T1EEK3_HELRO
Uncharacterized protein
Search

FZR1

0.65	Activator and specificity factor for anaphase promoting complex

0.83	GO:1904668	positive regulation of ubiquitin protein ligase activity
0.46	GO:0072425	signal transduction involved in G2 DNA damage checkpoint
0.46	GO:0031145	anaphase-promoting complex-dependent catabolic process
0.45	GO:0070306	lens fiber cell differentiation
0.45	GO:0090344	negative regulation of cell aging
0.44	GO:0045732	positive regulation of protein catabolic process
0.44	GO:0040020	regulation of meiotic nuclear division
0.43	GO:0008284	positive regulation of cell proliferation
0.41	GO:0051301	cell division
0.38	GO:2000058	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

0.84	GO:0097027	ubiquitin-protein transferase activator activity
0.84	GO:0010997	anaphase-promoting complex binding
0.36	GO:0030332	cyclin binding
0.33	GO:0003743	translation initiation factor activity

0.44	GO:0005680	anaphase-promoting complex
0.43	GO:0031965	nuclear membrane
0.41	GO:0005654	nucleoplasm
0.33	GO:0005829	cytosol

tr|T1EEK4|T1EEK4_HELRO
Uncharacterized protein
Search

TAF11

0.87	Transcription initiation factor TFIID subunit 11

0.79	GO:0006367	transcription initiation from RNA polymerase II promoter
0.57	GO:0006413	translational initiation
0.48	GO:0070897	DNA-templated transcriptional preinitiation complex assembly
0.47	GO:1901092	positive regulation of protein tetramerization
0.46	GO:0043923	positive regulation by host of viral transcription
0.46	GO:1900370	positive regulation of RNA interference
0.40	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:0042795	snRNA transcription by RNA polymerase II
0.34	GO:1901796	regulation of signal transduction by p53 class mediator
0.34	GO:0006368	transcription elongation from RNA polymerase II promoter

0.74	GO:0046982	protein heterodimerization activity
0.57	GO:0003743	translation initiation factor activity
0.48	GO:0008134	transcription factor binding
0.47	GO:0003713	transcription coactivator activity
0.45	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
0.45	GO:0047485	protein N-terminus binding
0.44	GO:0051427	hormone receptor binding
0.35	GO:0003677	DNA binding
0.34	GO:0070006	metalloaminopeptidase activity
0.32	GO:0046872	metal ion binding

0.61	GO:0005634	nucleus
0.49	GO:0000428	DNA-directed RNA polymerase complex
0.49	GO:0005667	transcription factor complex
0.46	GO:0031974	membrane-enclosed lumen
0.45	GO:0070578	RISC-loading complex
0.42	GO:0044446	intracellular organelle part
0.41	GO:0005794	Golgi apparatus
0.37	GO:0030529	intracellular ribonucleoprotein complex

tr|T1EEK5|T1EEK5_HELRO
Uncharacterized protein
Search

0.57	Jak pathway signal transduction adaptor molecule

0.68	GO:0006886	intracellular protein transport
0.57	GO:1903551	regulation of extracellular exosome assembly
0.56	GO:1903543	positive regulation of exosomal secretion
0.35	GO:0036258	multivesicular body assembly
0.35	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
0.34	GO:0016236	macroautophagy
0.34	GO:0016197	endosomal transport
0.34	GO:0016579	protein deubiquitination
0.34	GO:0009967	positive regulation of signal transduction
0.34	GO:0051056	regulation of small GTPase mediated signal transduction

0.51	GO:0044389	ubiquitin-like protein ligase binding
0.35	GO:0005070	SH3/SH2 adaptor activity
0.34	GO:0003690	double-stranded DNA binding
0.34	GO:0005096	GTPase activator activity
0.33	GO:0030246	carbohydrate binding
0.33	GO:0016757	transferase activity, transferring glycosyl groups

0.57	GO:0033565	ESCRT-0 complex
0.36	GO:0031901	early endosome membrane
0.33	GO:0005794	Golgi apparatus
0.33	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.33

GO:0016757

tr|T1EEK6|T1EEK6_HELRO
Uncharacterized protein
Search

0.43	cAMP-dependent protein kinase type II-alpha regulatory subunit

0.75	GO:0045859	regulation of protein kinase activity
0.50	GO:0016310	phosphorylation
0.46	GO:0048148	behavioral response to cocaine
0.45	GO:0048149	behavioral response to ethanol
0.45	GO:0045475	locomotor rhythm
0.43	GO:0007411	axon guidance
0.38	GO:0036211	protein modification process
0.37	GO:0033673	negative regulation of kinase activity
0.37	GO:0044267	cellular protein metabolic process
0.37	GO:0001933	negative regulation of protein phosphorylation

0.84	GO:0008603	cAMP-dependent protein kinase regulator activity
0.83	GO:0030552	cAMP binding
0.52	GO:0016301	kinase activity
0.39	GO:0060089	molecular transducer activity
0.39	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.39	GO:0034236	protein kinase A catalytic subunit binding
0.38	GO:0004862	cAMP-dependent protein kinase inhibitor activity
0.38	GO:0140096	catalytic activity, acting on a protein
0.37	GO:0031625	ubiquitin protein ligase binding
0.37	GO:0019904	protein domain specific binding

0.83	GO:0005952	cAMP-dependent protein kinase complex
0.38	GO:0031588	nucleotide-activated protein kinase complex
0.38	GO:0044853	plasma membrane raft
0.38	GO:0005930	axoneme
0.37	GO:0005813	centrosome
0.34	GO:0097546	ciliary base
0.34	GO:0005925	focal adhesion
0.34	GO:0070062	extracellular exosome
0.33	GO:0005829	cytosol
0.32	GO:0005743	mitochondrial inner membrane

0.39

GO:0016773

tr|T1EEK7|T1EEK7_HELRO
Uncharacterized protein
Search

0.43	Serine/threonine-protein kinase svkA

0.63	GO:0006468	protein phosphorylation
0.45	GO:0060439	trachea morphogenesis
0.45	GO:0019991	septate junction assembly
0.38	GO:0032147	activation of protein kinase activity
0.38	GO:0031098	stress-activated protein kinase signaling cascade
0.37	GO:0043406	positive regulation of MAP kinase activity
0.37	GO:0007346	regulation of mitotic cell cycle
0.37	GO:0031156	regulation of sorocarp development
0.36	GO:0042981	regulation of apoptotic process
0.36	GO:0010590	regulation of cell separation after cytokinesis

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0005057	signal transducer activity, downstream of receptor
0.35	GO:0042803	protein homodimerization activity

0.36	GO:0097610	cell surface furrow
0.36	GO:0032155	cell division site part
0.35	GO:0005813	centrosome
0.35	GO:0015629	actin cytoskeleton
0.35	GO:0005794	Golgi apparatus
0.30	GO:0016020	membrane

tr|T1EEK8|T1EEK8_HELRO
Guanylate cyclase
Search

0.43	Guanylate cyclase

0.81	GO:0006182	cGMP biosynthetic process
0.63	GO:0035556	intracellular signal transduction
0.61	GO:0006468	protein phosphorylation
0.44	GO:0060038	cardiac muscle cell proliferation
0.37	GO:0007168	receptor guanylyl cyclase signaling pathway
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0035725	sodium ion transmembrane transport
0.33	GO:0018212	peptidyl-tyrosine modification

0.82	GO:0004383	guanylate cyclase activity
0.61	GO:0004672	protein kinase activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0004016	adenylate cyclase activity
0.37	GO:0016941	natriuretic peptide receptor activity
0.35	GO:0020037	heme binding
0.34	GO:0005272	sodium channel activity
0.33	GO:0004930	G-protein coupled receptor activity

0.45	GO:0005622	intracellular
0.37	GO:0043234	protein complex
0.36	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.82

GO:0004383

tr|T1EEK9|T1EEK9_HELRO
Uncharacterized protein
Search

0.79	Nicotinic acetylcholine receptor subunit type A

0.78	GO:0060079	excitatory postsynaptic potential
0.60	GO:0034220	ion transmembrane transport
0.48	GO:0017085	response to insecticide
0.47	GO:0007271	synaptic transmission, cholinergic
0.47	GO:0046716	muscle cell cellular homeostasis
0.39	GO:0006812	cation transport

0.82	GO:0022848	acetylcholine-gated cation-selective channel activity
0.70	GO:0099600	transmembrane receptor activity
0.37	GO:0005509	calcium ion binding

0.78	GO:0045211	postsynaptic membrane
0.73	GO:0030054	cell junction
0.47	GO:0005892	acetylcholine-gated channel complex
0.35	GO:0042995	cell projection

tr|T1EEL0|T1EEL0_HELRO
Uncharacterized protein
Search

0.57	Biopterin-dependent aromatic amino acid hydroxylase

0.77	GO:0006559	L-phenylalanine catabolic process
0.53	GO:0055114	oxidation-reduction process
0.45	GO:0006726	eye pigment biosynthetic process
0.44	GO:0007616	long-term memory
0.40	GO:0071391	cellular response to estrogen stimulus
0.35	GO:0042427	serotonin biosynthetic process
0.34	GO:0018126	protein hydroxylation
0.34	GO:0046146	tetrahydrobiopterin metabolic process
0.34	GO:0006571	tyrosine biosynthetic process
0.33	GO:0006508	proteolysis

0.83	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
0.63	GO:0005506	iron ion binding
0.35	GO:0018683	camphor 5-monooxygenase activity
0.34	GO:0016597	amino acid binding
0.34	GO:0042803	protein homodimerization activity
0.33	GO:0004252	serine-type endopeptidase activity
0.32	GO:0048037	cofactor binding

0.34	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.83

EC:1.14.16

GO:0016714

tr|T1EEL1|T1EEL1_HELRO
Uncharacterized protein
Search

0.47	GO:0016310	phosphorylation
0.45	GO:0048701	embryonic cranial skeleton morphogenesis
0.45	GO:0030166	proteoglycan biosynthetic process
0.39	GO:0036211	protein modification process
0.37	GO:0044267	cellular protein metabolic process

0.49	GO:0016301	kinase activity
0.39	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.38	GO:0140096	catalytic activity, acting on a protein

0.30

GO:0044425

membrane part

0.39

GO:0016773

tr|T1EEL2|T1EEL2_HELRO
Transporter
Search

0.43	Sodium-dependent dopamine transporter

0.76	GO:0006836	neurotransmitter transport
0.55	GO:0055085	transmembrane transport
0.40	GO:0042221	response to chemical
0.40	GO:0051937	catecholamine transport
0.39	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration
0.38	GO:0007626	locomotory behavior
0.38	GO:0042745	circadian sleep/wake cycle
0.38	GO:0015696	ammonium transport
0.37	GO:0030431	sleep
0.37	GO:0030534	adult behavior

0.79	GO:0005328	neurotransmitter:sodium symporter activity
0.40	GO:0005329	dopamine transmembrane transporter activity
0.39	GO:0019811	cocaine binding
0.37	GO:0005283	sodium:amino acid symporter activity
0.36	GO:0015187	glycine transmembrane transporter activity
0.34	GO:0004784	superoxide dismutase activity
0.33	GO:0046872	metal ion binding

0.41	GO:0005887	integral component of plasma membrane
0.39	GO:0044456	synapse part
0.38	GO:0097458	neuron part
0.35	GO:0120025	plasma membrane bounded cell projection

0.34

EC:1.15.1.1

GO:0004784

tr|T1EEL3|T1EEL3_HELRO
Uncharacterized protein
Search

MAPKAPK2

0.85	Mitogen-activated protein kinase-activated protein kinase 2

0.63	GO:0006468	protein phosphorylation
0.56	GO:0044351	macropinocytosis
0.53	GO:0018209	peptidyl-serine modification
0.53	GO:0070935	3'-UTR-mediated mRNA stabilization
0.52	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
0.52	GO:0002224	toll-like receptor signaling pathway
0.52	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.52	GO:0032496	response to lipopolysaccharide
0.52	GO:0035924	cellular response to vascular endothelial growth factor stimulus
0.50	GO:0032675	regulation of interleukin-6 production

0.66	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0051019	mitogen-activated protein kinase binding
0.48	GO:0010857	calcium-dependent protein kinase activity
0.45	GO:0005516	calmodulin binding
0.41	GO:0004871	signal transducer activity

0.47	GO:0005813	centrosome
0.46	GO:0005654	nucleoplasm
0.38	GO:0005737	cytoplasm
0.37	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.66

GO:0004674

tr|T1EEL4|T1EEL4_HELRO
Uncharacterized protein
Search

PHC1

0.76	Polyhomeotic homolog 1 (Fragment)

0.58	GO:1903507	negative regulation of nucleic acid-templated transcription
0.49	GO:0048635	negative regulation of muscle organ development
0.49	GO:0006355	regulation of transcription, DNA-templated
0.44	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
0.43	GO:0010629	negative regulation of gene expression
0.36	GO:0007283	spermatogenesis
0.35	GO:0016569	covalent chromatin modification
0.35	GO:0030154	cell differentiation
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:0006869	lipid transport

0.65	GO:0003714	transcription corepressor activity
0.64	GO:0042393	histone binding
0.53	GO:0008270	zinc ion binding
0.37	GO:0043565	sequence-specific DNA binding
0.33	GO:0005319	lipid transporter activity
0.32	GO:0003700	DNA binding transcription factor activity

0.61	GO:0005634	nucleus
0.43	GO:0031974	membrane-enclosed lumen
0.40	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

tr|T1EEL5|T1EEL5_HELRO
Uncharacterized protein
Search

PITHD1

0.53	PITH domain-containing protein 1

0.61	GO:0006974	cellular response to DNA damage stimulus
0.40	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.39	GO:0006259	DNA metabolic process
0.35	GO:0055085	transmembrane transport

0.40

GO:0004518

nuclease activity

0.56	GO:0005634	nucleus
0.47	GO:1905369	endopeptidase complex
0.42	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.40

EC:3.1

GO:0004518

tr|T1EEL6|T1EEL6_HELRO
Uncharacterized protein
Search

GRWD1

0.64	glutamate-rich WD repeat-containing protein 1

0.34

GO:0006412

translation

0.35	GO:0019904	protein domain specific binding
0.34	GO:0046983	protein dimerization activity
0.34	GO:0003735	structural constituent of ribosome

0.61	GO:0005634	nucleus
0.34	GO:0005840	ribosome
0.30	GO:0044425	membrane part

tr|T1EEL7|T1EEL7_HELRO
Uncharacterized protein
Search

0.44	Methyltransferase like 26

tr|T1EEL8|T1EEL8_HELRO
Uncharacterized protein
Search

TMEM147

0.44	Transmembrane protein 147

0.52	GO:0031648	protein destabilization
0.34	GO:0045727	positive regulation of translation
0.34	GO:0035235	ionotropic glutamate receptor signaling pathway
0.33	GO:0006006	glucose metabolic process
0.33	GO:0043043	peptide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process
0.32	GO:0010467	gene expression
0.32	GO:0009059	macromolecule biosynthetic process
0.32	GO:0055114	oxidation-reduction process

0.34	GO:0005515	protein binding
0.34	GO:0004970	ionotropic glutamate receptor activity
0.34	GO:0043022	ribosome binding
0.33	GO:0050661	NADP binding
0.33	GO:0003924	GTPase activity
0.33	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.33	GO:0051287	NAD binding
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding

0.46	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0005759	mitochondrial matrix
0.33	GO:0031966	mitochondrial membrane
0.33	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.33

GO:0016620

tr|T1EEL9|T1EEL9_HELRO
Uncharacterized protein
Search

0.53

GO:0005975

carbohydrate metabolic process

0.58	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.42	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

0.30

GO:0044425

membrane part

0.58

GO:0004553

tr|T1EEM0|T1EEM0_HELRO
Uncharacterized protein
Search

0.51	GO:0055114	oxidation-reduction process
0.33	GO:0051301	cell division

0.52	GO:0016491	oxidoreductase activity
0.38	GO:0004312	fatty acid synthase activity

0.30

GO:0044425

membrane part

0.52

GO:0016491

tr|T1EEM1|T1EEM1_HELRO
Uncharacterized protein
Search

0.59	Ankyrin repeat domain-containing protein 13C-A

0.51	GO:0010869	regulation of receptor biosynthetic process
0.49	GO:0006621	protein retention in ER lumen
0.36	GO:0006468	protein phosphorylation
0.36	GO:0007165	signal transduction

0.45	GO:0005102	receptor binding
0.40	GO:0004703	G-protein coupled receptor kinase activity
0.37	GO:0003723	RNA binding
0.36	GO:0046872	metal ion binding
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding

0.53	GO:0043231	intracellular membrane-bounded organelle
0.46	GO:0012505	endomembrane system
0.44	GO:0005737	cytoplasm
0.40	GO:0097708	intracellular vesicle
0.36	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.40

EC:2.7.11.16

GO:0004703

tr|T1EEM2|T1EEM2_HELRO
Peptidyl-prolyl cis-trans isomerase
Search

PPIL6

0.40	Peptidyl-prolyl cis-trans isomerase

0.72	GO:0000413	protein peptidyl-prolyl isomerization
0.39	GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain
0.34	GO:0006457	protein folding
0.33	GO:0043043	peptide biosynthetic process
0.33	GO:0016567	protein ubiquitination
0.32	GO:0010467	gene expression
0.32	GO:0009059	macromolecule biosynthetic process

0.72	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.42	GO:0003723	RNA binding
0.41	GO:0008270	zinc ion binding
0.33	GO:0003735	structural constituent of ribosome
0.33	GO:0004842	ubiquitin-protein transferase activity

0.36	GO:0005829	cytosol
0.35	GO:0005634	nucleus
0.33	GO:0005840	ribosome
0.30	GO:0016020	membrane

0.72	EC:5.2.1.8	GO:0003755
0.33	KEGG:R03876	GO:0004842

tr|T1EEM3|T1EEM3_HELRO
Uncharacterized protein
Search

0.63	Histone-arginine methyltransferase CARMER

0.73	GO:0008213	protein alkylation
0.67	GO:0043414	macromolecule methylation
0.45	GO:0018195	peptidyl-arginine modification
0.43	GO:0016570	histone modification
0.40	GO:0003420	regulation of growth plate cartilage chondrocyte proliferation
0.39	GO:0006338	chromatin remodeling
0.39	GO:0030520	intracellular estrogen receptor signaling pathway
0.39	GO:0045595	regulation of cell differentiation
0.39	GO:0033146	regulation of intracellular estrogen receptor signaling pathway
0.39	GO:0071168	protein localization to chromatin

0.63	GO:0008168	methyltransferase activity
0.39	GO:0001105	RNA polymerase II transcription coactivator activity
0.39	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
0.39	GO:0070577	lysine-acetylated histone binding
0.38	GO:0140096	catalytic activity, acting on a protein
0.37	GO:0044212	transcription regulatory region DNA binding
0.37	GO:0042803	protein homodimerization activity
0.34	GO:0008013	beta-catenin binding
0.32	GO:0016787	hydrolase activity

0.39	GO:0005829	cytosol
0.39	GO:0005654	nucleoplasm
0.37	GO:0090575	RNA polymerase II transcription factor complex
0.37	GO:0034708	methyltransferase complex
0.30	GO:0016020	membrane

0.63

GO:0008168

tr|T1EEM4|T1EEM4_HELRO
Uncharacterized protein
Search

0.40	Sodium-dependent phosphate transporter

0.55	GO:0055085	transmembrane transport
0.43	GO:0006817	phosphate ion transport
0.37	GO:1905852	positive regulation of backward locomotion
0.37	GO:0061094	regulation of turning behavior involved in mating
0.37	GO:1902436	negative regulation of male mating behavior
0.37	GO:0043051	regulation of pharyngeal pumping
0.36	GO:0035249	synaptic transmission, glutamatergic
0.36	GO:0006972	hyperosmotic response
0.36	GO:0008344	adult locomotory behavior
0.36	GO:0009612	response to mechanical stimulus

0.45	GO:0015114	phosphate ion transmembrane transporter activity
0.34	GO:0015293	symporter activity
0.34	GO:0015136	sialic acid transmembrane transporter activity
0.33	GO:0008378	galactosyltransferase activity
0.32	GO:0008233	peptidase activity

0.34	GO:0005887	integral component of plasma membrane
0.33	GO:0005765	lysosomal membrane
0.33	GO:0031410	cytoplasmic vesicle
0.33	GO:0005829	cytosol
0.32	GO:0005739	mitochondrion

0.33

GO:0008378

tr|T1EEM5|T1EEM5_HELRO
Uncharacterized protein
Search

0.10	Serine/threonine-protein kinase 17A

0.63	GO:0006468	protein phosphorylation
0.47	GO:2000271	positive regulation of fibroblast apoptotic process
0.45	GO:2000377	regulation of reactive oxygen species metabolic process
0.40	GO:0035556	intracellular signal transduction
0.36	GO:0018210	peptidyl-threonine modification
0.36	GO:0006915	apoptotic process
0.36	GO:0018209	peptidyl-serine modification
0.34	GO:0060298	positive regulation of sarcomere organization
0.34	GO:0035095	behavioral response to nicotine
0.34	GO:0045989	positive regulation of striated muscle contraction

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0019901	protein kinase binding
0.32	GO:0009982	pseudouridine synthase activity
0.31	GO:0003723	RNA binding
0.31	GO:0046872	metal ion binding

0.43	GO:0016607	nuclear speck
0.37	GO:0005886	plasma membrane
0.34	GO:0031672	A band
0.30	GO:0031224	intrinsic component of membrane

0.32

EC:5.4.99.12

GO:0009982

tr|T1EEM6|T1EEM6_HELRO
Uncharacterized protein
Search

0.51	Prefoldin, alpha subunit

0.69	GO:0006457	protein folding
0.57	GO:0007021	tubulin complex assembly
0.55	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
0.35	GO:0000413	protein peptidyl-prolyl isomerization
0.33	GO:0006396	RNA processing

0.71	GO:0051082	unfolded protein binding
0.51	GO:0015631	tubulin binding
0.35	GO:0043022	ribosome binding
0.35	GO:0003755	peptidyl-prolyl cis-trans isomerase activity

0.80	GO:0016272	prefoldin complex
0.58	GO:0051286	cell tip
0.53	GO:0032153	cell division site
0.41	GO:0005737	cytoplasm
0.34	GO:0000178	exosome (RNase complex)
0.30	GO:0016020	membrane

0.35

GO:0003755

tr|T1EEM7|T1EEM7_HELRO
Uncharacterized protein
Search

HTATSF1

0.63	HIV Tat-specific factor 1

0.75	GO:0000398	mRNA splicing, via spliceosome
0.37	GO:0006414	translational elongation
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression
0.34	GO:0019079	viral genome replication
0.33	GO:0015937	coenzyme A biosynthetic process
0.32	GO:0016310	phosphorylation

0.59	GO:0003723	RNA binding
0.34	GO:0004140	dephospho-CoA kinase activity
0.33	GO:0043565	sequence-specific DNA binding
0.33	GO:0008270	zinc ion binding
0.32	GO:0003700	DNA binding transcription factor activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.46	GO:0005686	U2 snRNP
0.46	GO:0005684	U2-type spliceosomal complex
0.44	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.34	EC:2.7.1.24	GO:0004140
0.34	KEGG:R00130	GO:0004140

tr|T1EEM8|T1EEM8_HELRO
Uncharacterized protein
Search

0.73	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase

0.81

GO:0016266

O-glycan processing

0.82	GO:0016263	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity
0.35	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
0.34	GO:0046872	metal ion binding

0.30

GO:0031224

intrinsic component of membrane

0.82

EC:2.4.1.122

GO:0016263

tr|T1EEM9|T1EEM9_HELRO
Uncharacterized protein
Search

DENND5A

0.86	DENN domain-containing protein 5A

0.73	GO:0042147	retrograde transport, endosome to Golgi
0.70	GO:0050982	detection of mechanical stimulus
0.63	GO:0070588	calcium ion transmembrane transport
0.61	GO:0065009	regulation of molecular function
0.47	GO:0010977	negative regulation of neuron projection development

0.78	GO:0017112	Rab guanyl-nucleotide exchange factor activity
0.65	GO:0005262	calcium channel activity

0.74	GO:0030904	retromer complex
0.72	GO:0005802	trans-Golgi network
0.63	GO:0005829	cytosol
0.44	GO:0000139	Golgi membrane
0.30	GO:0016021	integral component of membrane

tr|T1EEN0|T1EEN0_HELRO
Uncharacterized protein
Search

0.78	Ethanolamine-phosphate phospho-lyase

0.44	GO:0035094	response to nicotine
0.36	GO:0035162	embryonic hemopoiesis
0.34	GO:0006979	response to oxidative stress
0.34	GO:0006646	phosphatidylethanolamine biosynthetic process
0.34	GO:0098869	cellular oxidant detoxification
0.34	GO:0006869	lipid transport
0.32	GO:0055114	oxidation-reduction process

0.69	GO:0008483	transaminase activity
0.67	GO:0030170	pyridoxal phosphate binding
0.46	GO:0016829	lyase activity
0.38	GO:0042802	identical protein binding
0.35	GO:0004096	catalase activity
0.34	GO:0005319	lipid transporter activity
0.33	GO:0020037	heme binding

0.36	GO:0005739	mitochondrion
0.33	GO:0070013	intracellular organelle lumen
0.32	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.69

EC:2.6.1

GO:0008483

tr|T1EEN1|T1EEN1_HELRO
Uncharacterized protein
Search

0.58	GO:0006362	transcription elongation from RNA polymerase I promoter
0.58	GO:0007256	activation of JNKK activity
0.58	GO:0007257	activation of JUN kinase activity
0.57	GO:0010165	response to X-ray
0.57	GO:0006290	pyrimidine dimer repair
0.57	GO:0045494	photoreceptor cell maintenance
0.57	GO:0061098	positive regulation of protein tyrosine kinase activity
0.56	GO:0010224	response to UV-B
0.56	GO:0010332	response to gamma radiation
0.56	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage

0.58	GO:0030296	protein tyrosine kinase activator activity
0.56	GO:0047485	protein N-terminus binding
0.55	GO:0008022	protein C-terminus binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0003682	chromatin binding
0.51	GO:0032403	protein complex binding
0.49	GO:0008094	DNA-dependent ATPase activity
0.42	GO:0003677	DNA binding

0.53	GO:0008023	transcription elongation factor complex
0.51	GO:0005730	nucleolus

0.33

GO:0016740

tr|T1EEN2|T1EEN2_HELRO
Uncharacterized protein
Search

0.80	Serine threonine-protein kinase minibrain

0.75	GO:0046777	protein autophosphorylation
0.49	GO:0018108	peptidyl-tyrosine phosphorylation
0.36	GO:0001706	endoderm formation
0.35	GO:1900244	positive regulation of synaptic vesicle endocytosis
0.35	GO:0035332	positive regulation of hippo signaling
0.35	GO:2000253	positive regulation of feeding behavior
0.35	GO:0045887	positive regulation of synaptic growth at neuromuscular junction
0.35	GO:0008355	olfactory learning
0.34	GO:0007632	visual behavior
0.34	GO:0007623	circadian rhythm

0.75	GO:0004712	protein serine/threonine/tyrosine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0004674	protein serine/threonine kinase activity
0.49	GO:0004713	protein tyrosine kinase activity
0.34	GO:0005515	protein binding
0.33	GO:0004252	serine-type endopeptidase activity
0.32	GO:0008168	methyltransferase activity
0.32	GO:0003723	RNA binding

0.34	GO:0043195	terminal bouton
0.33	GO:0005615	extracellular space
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.75

EC:2.7.12.1

GO:0004712

tr|T1EEN3|T1EEN3_HELRO
Uncharacterized protein
Search

0.51	N-acylsphingosine amidohydrolase 2

0.47	GO:0006665	sphingolipid metabolic process
0.40	GO:0034599	cellular response to oxidative stress
0.40	GO:0043603	cellular amide metabolic process
0.38	GO:0090156	cellular sphingolipid homeostasis
0.35	GO:0032259	methylation
0.35	GO:0006568	tryptophan metabolic process
0.34	GO:0010467	gene expression
0.34	GO:0009059	macromolecule biosynthetic process
0.34	GO:0044271	cellular nitrogen compound biosynthetic process
0.34	GO:0044267	cellular protein metabolic process

0.59	GO:0017040	ceramidase activity
0.35	GO:0004640	phosphoribosylanthranilate isomerase activity
0.35	GO:0004425	indole-3-glycerol-phosphate synthase activity
0.35	GO:0008168	methyltransferase activity
0.35	GO:0003735	structural constituent of ribosome
0.34	GO:0003700	DNA binding transcription factor activity
0.33	GO:0003677	DNA binding

0.45	GO:0016324	apical plasma membrane
0.44	GO:0005794	Golgi apparatus
0.44	GO:0005783	endoplasmic reticulum
0.43	GO:0098588	bounding membrane of organelle
0.42	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.41	GO:0005739	mitochondrion
0.41	GO:0031984	organelle subcompartment
0.38	GO:0005576	extracellular region
0.36	GO:0044437	vacuolar part
0.36	GO:0098805	whole membrane

0.59	EC:3.5.1.23	GO:0017040
0.35	KEGG:R03509	GO:0004640

tr|T1EEN4|T1EEN4_HELRO
Uncharacterized protein
Search

MCU

0.91	Mitochondrial calcium uniporter

0.43	GO:0036444	mitochondrial calcium uptake
0.43	GO:0051560	mitochondrial calcium ion homeostasis
0.41	GO:0035786	protein complex oligomerization
0.40	GO:0032024	positive regulation of insulin secretion
0.40	GO:0019722	calcium-mediated signaling
0.39	GO:0042593	glucose homeostasis
0.35	GO:0007615	anesthesia-resistant memory
0.35	GO:0072375	medium-term memory
0.35	GO:0060027	convergent extension involved in gastrulation
0.34	GO:0008016	regulation of heart contraction

0.44	GO:0015292	uniporter activity
0.41	GO:0005262	calcium channel activity
0.37	GO:0042802	identical protein binding

0.43	GO:1990246	uniplex complex
0.41	GO:0031305	integral component of mitochondrial inner membrane

tr|T1EEN5|T1EEN5_HELRO
Uncharacterized protein
Search

ECR

0.72	oxysterols receptor LXR-beta

0.77	GO:0043401	steroid hormone mediated signaling pathway
0.72	GO:0030522	intracellular receptor signaling pathway
0.68	GO:0071390	cellular response to ecdysone
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.45	GO:0051546	keratinocyte migration
0.45	GO:0043415	positive regulation of skeletal muscle tissue regeneration
0.44	GO:2000288	positive regulation of myoblast proliferation

0.78	GO:0003707	steroid hormone receptor activity
0.74	GO:0004879	nuclear receptor activity
0.65	GO:0043565	sequence-specific DNA binding
0.64	GO:0005496	steroid binding
0.63	GO:0008270	zinc ion binding
0.46	GO:0070539	linoleic acid binding
0.43	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.41	GO:0008134	transcription factor binding
0.41	GO:0046982	protein heterodimerization activity
0.36	GO:0008144	drug binding

0.61	GO:0005634	nucleus
0.40	GO:0000785	chromatin
0.40	GO:0043233	organelle lumen
0.34	GO:0005829	cytosol
0.33	GO:0000793	condensed chromosome
0.30	GO:0016020	membrane

tr|T1EEN6|T1EEN6_HELRO
Uncharacterized protein
Search

0.13	Probable G-protein coupled receptor 179

0.30

GO:0044425

membrane part

tr|T1EEN7|T1EEN7_HELRO
Uncharacterized protein
Search

RAB37

0.68	Ras and EF-hand domain-containing protein-like protein

0.42	GO:0072659	protein localization to plasma membrane
0.41	GO:0006887	exocytosis
0.40	GO:0017157	regulation of exocytosis
0.40	GO:0048278	vesicle docking
0.38	GO:0015031	protein transport
0.38	GO:0002790	peptide secretion
0.36	GO:0035272	exocrine system development
0.36	GO:0006893	Golgi to plasma membrane transport
0.35	GO:0090150	establishment of protein localization to membrane

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0004379	glycylpeptide N-tetradecanoyltransferase activity
0.34	GO:0005509	calcium ion binding
0.33	GO:0008270	zinc ion binding
0.32	GO:0003676	nucleic acid binding

0.42	GO:0030667	secretory granule membrane
0.40	GO:0008021	synaptic vesicle
0.39	GO:0005768	endosome
0.37	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.35	GO:0005886	plasma membrane
0.35	GO:0000139	Golgi membrane
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.37

EC:2.3.1.97

GO:0004379

tr|T1EEN8|T1EEN8_HELRO
Uncharacterized protein
Search

0.11	Transmembrane protein 194A

0.48	GO:0005635	nuclear envelope
0.35	GO:0019866	organelle inner membrane
0.35	GO:0005581	collagen trimer
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEN9|T1EEN9_HELRO
Uncharacterized protein
Search

TDH

0.67	L-threonine dehydrogenase

0.47	GO:0006567	threonine catabolic process
0.38	GO:0055114	oxidation-reduction process
0.35	GO:0006544	glycine metabolic process
0.35	GO:0042737	drug catabolic process

0.60	GO:0050662	coenzyme binding
0.49	GO:0008743	L-threonine 3-dehydrogenase activity
0.45	GO:0042802	identical protein binding
0.34	GO:0003978	UDP-glucose 4-epimerase activity

0.41	GO:0005739	mitochondrion
0.32	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.49	EC:1.1.1.103	GO:0008743
0.49	KEGG:R01465	GO:0008743

tr|T1EEP0|T1EEP0_HELRO
Uncharacterized protein
Search

0.38	Tyrosine-protein phosphatase

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.38	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
0.35	GO:0000188	inactivation of MAPK activity
0.35	GO:0043937	regulation of sporulation
0.34	GO:0032880	regulation of protein localization
0.34	GO:0006468	protein phosphorylation
0.34	GO:0007124	pseudohyphal growth
0.34	GO:0001403	invasive growth in response to glucose limitation
0.33	GO:0051301	cell division
0.33	GO:0007049	cell cycle

0.75	GO:0004725	protein tyrosine phosphatase activity
0.37	GO:0050254	rhodopsin kinase activity
0.33	GO:0019198	transmembrane receptor protein phosphatase activity

0.34	GO:0005634	nucleus
0.33	GO:0005856	cytoskeleton
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.75

GO:0004725

tr|T1EEP1|T1EEP1_HELRO
Uncharacterized protein
Search

0.56	Ubiquitin-protein ligase E3C

0.70

GO:0016567

protein ubiquitination

0.71	GO:0004842	ubiquitin-protein transferase activity
0.56	GO:0016874	ligase activity
0.44	GO:0061659	ubiquitin-like protein ligase activity
0.33	GO:0005515	protein binding

0.36	GO:0005737	cytoplasm
0.34	GO:0005634	nucleus
0.34	GO:1905369	endopeptidase complex
0.33	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

0.56	EC:6	GO:0016874
0.71	KEGG:R03876	GO:0004842

tr|T1EEP2|T1EEP2_HELRO
Uncharacterized protein
Search

DHAK

0.42	PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK

0.76	GO:0006071	glycerol metabolic process
0.57	GO:0016310	phosphorylation
0.43	GO:2000142	regulation of DNA-templated transcription, initiation
0.43	GO:0006352	DNA-templated transcription, initiation

0.79	GO:0004371	glycerone kinase activity
0.44	GO:0030246	carbohydrate binding
0.43	GO:0000996	promoter selection factor activity
0.42	GO:0032559	adenyl ribonucleotide binding
0.42	GO:0008144	drug binding
0.42	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0003700	DNA binding transcription factor activity
0.38	GO:0003677	DNA binding
0.33	GO:0004386	helicase activity
0.33	GO:0016829	lyase activity

0.30

GO:0016020

membrane

0.79	EC:2.7.1.29	GO:0004371
0.79	KEGG:R01011	GO:0004371

tr|T1EEP3|T1EEP3_HELRO
Uncharacterized protein
Search

tr|T1EEP4|T1EEP4_HELRO
Uncharacterized protein
Search

0.10	Matrix metalloproteinase

0.61	GO:0006508	proteolysis
0.52	GO:0030574	collagen catabolic process
0.50	GO:0035988	chondrocyte proliferation
0.50	GO:0097094	craniofacial suture morphogenesis
0.50	GO:0001958	endochondral ossification
0.48	GO:0048598	embryonic morphogenesis
0.47	GO:0048706	embryonic skeletal system development
0.46	GO:0048568	embryonic organ development
0.44	GO:0051604	protein maturation
0.41	GO:0009888	tissue development

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.45	GO:0070006	metalloaminopeptidase activity
0.39	GO:0005518	collagen binding
0.39	GO:0001047	core promoter binding
0.37	GO:0005509	calcium ion binding
0.36	GO:0043565	sequence-specific DNA binding
0.34	GO:0008061	chitin binding
0.33	GO:0042802	identical protein binding
0.33	GO:0008047	enzyme activator activity

0.74	GO:0031012	extracellular matrix
0.49	GO:0005887	integral component of plasma membrane
0.38	GO:0005615	extracellular space
0.36	GO:0005581	collagen trimer
0.35	GO:0005634	nucleus
0.34	GO:0005796	Golgi lumen
0.33	GO:1903561	extracellular vesicle
0.33	GO:0009986	cell surface

0.70

GO:0004222

tr|T1EEP5|T1EEP5_HELRO
Uncharacterized protein
Search

0.49	GO:0043654	recognition of apoptotic cell
0.49	GO:0014841	skeletal muscle satellite cell proliferation
0.48	GO:0014719	skeletal muscle satellite cell activation
0.48	GO:0014816	skeletal muscle satellite cell differentiation
0.47	GO:0051451	myoblast migration
0.47	GO:0043652	engulfment of apoptotic cell
0.46	GO:0034109	homotypic cell-cell adhesion
0.46	GO:1902742	apoptotic process involved in development
0.46	GO:0048641	regulation of skeletal muscle tissue development
0.46	GO:0051147	regulation of muscle cell differentiation

0.62	GO:0005509	calcium ion binding
0.48	GO:0001849	complement component C1q binding
0.46	GO:0005112	Notch binding
0.45	GO:0005044	scavenger receptor activity
0.39	GO:0005520	insulin-like growth factor binding
0.35	GO:0005201	extracellular matrix structural constituent
0.34	GO:0008061	chitin binding
0.33	GO:0004222	metalloendopeptidase activity
0.33	GO:0030247	polysaccharide binding
0.32	GO:0042802	identical protein binding

0.48	GO:0001891	phagocytic cup
0.39	GO:0005576	extracellular region
0.33	GO:0005634	nucleus
0.32	GO:0005903	brush border
0.32	GO:0016324	apical plasma membrane
0.32	GO:0030139	endocytic vesicle
0.32	GO:0005905	clathrin-coated pit
0.32	GO:0042995	cell projection
0.32	GO:0005768	endosome
0.32	GO:0005794	Golgi apparatus

0.33

GO:0004222

tr|T1EEP6|T1EEP6_HELRO
Uncharacterized protein
Search

0.10	Proline dehydrogenase

0.79	GO:0006562	proline catabolic process
0.53	GO:0055114	oxidation-reduction process
0.38	GO:0006536	glutamate metabolic process
0.35	GO:0042331	phototaxis
0.35	GO:0007626	locomotory behavior

0.80	GO:0004657	proline dehydrogenase activity
0.45	GO:0005509	calcium ion binding
0.38	GO:0071949	FAD binding

0.36	GO:0005739	mitochondrion
0.30	GO:0044425	membrane part

0.80

EC:1.5.99.8

GO:0004657

tr|T1EEP7|T1EEP7_HELRO
Uncharacterized protein
Search

0.85	E3 ubiquitin-protein ligase CHIP

0.73	GO:0016567	protein ubiquitination
0.48	GO:0017062	respiratory chain complex III assembly
0.48	GO:0097033	mitochondrial respiratory chain complex III biogenesis
0.47	GO:0033108	mitochondrial respiratory chain complex assembly
0.45	GO:0046627	negative regulation of insulin receptor signaling pathway
0.44	GO:0030001	metal ion transport
0.40	GO:0055085	transmembrane transport
0.36	GO:0045454	cell redox homeostasis
0.35	GO:0030579	ubiquitin-dependent SMAD protein catabolic process
0.35	GO:0031943	regulation of glucocorticoid metabolic process

0.74	GO:0004842	ubiquitin-protein transferase activity
0.45	GO:0046873	metal ion transmembrane transporter activity
0.44	GO:0061659	ubiquitin-like protein ligase activity
0.42	GO:0016874	ligase activity
0.41	GO:0046983	protein dimerization activity
0.39	GO:0032559	adenyl ribonucleotide binding
0.38	GO:0008144	drug binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0016972	thiol oxidase activity
0.35	GO:0030911	TPR domain binding

0.49	GO:0000813	ESCRT I complex
0.46	GO:0030018	Z disc
0.41	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.42	EC:6	GO:0016874
0.74	KEGG:R03876	GO:0004842

tr|T1EEP8|T1EEP8_HELRO
Uncharacterized protein
Search

CHIC1

0.95	Cysteine-rich hydrophobic domain

0.33

GO:0007186

G-protein coupled receptor signaling pathway

0.33

GO:0004930

G-protein coupled receptor activity

0.35	GO:0031410	cytoplasmic vesicle
0.33	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

tr|T1EEP9|T1EEP9_HELRO
Uncharacterized protein
Search

RAB3GAP1

0.57	Rab3 GTPase-activating protein catalytic subunit

0.76	GO:0043547	positive regulation of GTPase activity
0.62	GO:0061646	positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization
0.61	GO:1903233	regulation of calcium ion-dependent exocytosis of neurotransmitter
0.61	GO:1903373	positive regulation of endoplasmic reticulum tubular network organization
0.61	GO:0097051	establishment of protein localization to endoplasmic reticulum membrane
0.61	GO:1903061	positive regulation of protein lipidation
0.60	GO:0048172	regulation of short-term neuronal synaptic plasticity
0.59	GO:2000786	positive regulation of autophagosome assembly
0.59	GO:0021854	hypothalamus development
0.59	GO:0060325	face morphogenesis

0.76	GO:0005096	GTPase activator activity
0.57	GO:0017112	Rab guanyl-nucleotide exchange factor activity

0.58	GO:0071782	endoplasmic reticulum tubular network
0.56	GO:0005811	lipid droplet
0.53	GO:0098794	postsynapse
0.50	GO:0005794	Golgi apparatus
0.45	GO:0043234	protein complex
0.34	GO:0070062	extracellular exosome
0.34	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

tr|T1EEQ0|T1EEQ0_HELRO
Palmitoyltransferase
Search

0.37	Palmitoyltransferase

0.33

GO:0055114

oxidation-reduction process

0.78	GO:0019706	protein-cysteine S-palmitoyltransferase activity
0.39	GO:0005201	extracellular matrix structural constituent
0.33	GO:0016491	oxidoreductase activity

0.39	GO:0005604	basement membrane
0.38	GO:0005581	collagen trimer
0.38	GO:0005783	endoplasmic reticulum
0.30	GO:0044425	membrane part

0.78

GO:0019706

tr|T1EEQ1|T1EEQ1_HELRO
Uncharacterized protein
Search

LOC106177724

0.90	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

0.52	GO:0055114	oxidation-reduction process
0.33	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
0.33	GO:0032259	methylation

0.54	GO:0016491	oxidoreductase activity
0.33	GO:0008168	methyltransferase activity
0.32	GO:0051536	iron-sulfur cluster binding

0.33

GO:0005759

mitochondrial matrix

0.54

GO:0016491

tr|T1EEQ2|T1EEQ2_HELRO
Uncharacterized protein
Search

0.59

Lachesin

0.30

GO:0044425

membrane part

tr|T1EEQ3|T1EEQ3_HELRO
Uncharacterized protein
Search

PIKFYVE

0.47	Phosphoinositide kinase, FYVE finger containing

0.75	GO:0046854	phosphatidylinositol phosphorylation
0.59	GO:0035556	intracellular signal transduction
0.51	GO:2000785	regulation of autophagosome assembly
0.49	GO:0042147	retrograde transport, endosome to Golgi
0.48	GO:0032288	myelin assembly
0.46	GO:0034504	protein localization to nucleus
0.46	GO:0006458	'de novo' protein folding
0.45	GO:0061077	chaperone-mediated protein folding
0.37	GO:0097352	autophagosome maturation
0.37	GO:0008333	endosome to lysosome transport

0.82	GO:0016307	phosphatidylinositol phosphate kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0046872	metal ion binding
0.47	GO:0044183	protein binding involved in protein folding
0.42	GO:0051082	unfolded protein binding
0.35	GO:0052810	1-phosphatidylinositol-5-kinase activity

0.49	GO:0048471	perinuclear region of cytoplasm
0.48	GO:0010008	endosome membrane
0.46	GO:0045121	membrane raft
0.46	GO:0005769	early endosome
0.45	GO:0005829	cytosol
0.44	GO:0005911	cell-cell junction
0.44	GO:0012506	vesicle membrane
0.36	GO:0032593	insulin-responsive compartment
0.34	GO:0005770	late endosome
0.33	GO:0000139	Golgi membrane

0.82

GO:0016307

tr|T1EEQ4|T1EEQ4_HELRO
Uncharacterized protein
Search

0.50	GO:0055114	oxidation-reduction process
0.48	GO:0030073	insulin secretion
0.46	GO:0042593	glucose homeostasis
0.44	GO:0006801	superoxide metabolic process
0.44	GO:0048468	cell development
0.44	GO:0046677	response to antibiotic
0.39	GO:0006091	generation of precursor metabolites and energy
0.34	GO:0007160	cell-matrix adhesion
0.34	GO:0006739	NADP metabolic process
0.33	GO:0000398	mRNA splicing, via spliceosome

0.58	GO:0020037	heme binding
0.51	GO:0016491	oxidoreductase activity
0.50	GO:0046872	metal ion binding
0.34	GO:0045131	pre-mRNA branch point binding
0.33	GO:0050660	flavin adenine dinucleotide binding
0.33	GO:0005515	protein binding

0.45	GO:0048471	perinuclear region of cytoplasm
0.43	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane

0.51

GO:0016491

tr|T1EEQ5|T1EEQ5_HELRO
alpha-1,2-Mannosidase
Search

EDEM3

0.47	ER degradation-enhancing alpha-mannosidase-like protein 3

0.75	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway
0.45	GO:0006986	response to unfolded protein
0.45	GO:0006491	N-glycan processing
0.44	GO:0035967	cellular response to topologically incorrect protein
0.38	GO:0007165	signal transduction
0.36	GO:0043413	macromolecule glycosylation
0.36	GO:0009101	glycoprotein biosynthetic process
0.33	GO:0009072	aromatic amino acid family metabolic process

0.82	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
0.70	GO:0005509	calcium ion binding
0.34	GO:0004334	fumarylacetoacetase activity

0.49	GO:0005788	endoplasmic reticulum lumen
0.35	GO:0044322	endoplasmic reticulum quality control compartment
0.30	GO:0016020	membrane

0.82	EC:3.2.1.113	GO:0004571
0.82	KEGG:R05982 KEGG:R06722	GO:0004571

tr|T1EEQ6|T1EEQ6_HELRO
Uncharacterized protein
Search

0.38	GO:0006357	regulation of transcription by RNA polymerase II
0.36	GO:0010467	gene expression
0.36	GO:0009059	macromolecule biosynthetic process
0.36	GO:0043043	peptide biosynthetic process
0.35	GO:0044260	cellular macromolecule metabolic process
0.35	GO:0016070	RNA metabolic process
0.35	GO:0034654	nucleobase-containing compound biosynthetic process
0.34	GO:0019538	protein metabolic process

0.51	GO:0003676	nucleic acid binding
0.38	GO:0008270	zinc ion binding
0.38	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.36	GO:0003735	structural constituent of ribosome

0.38	GO:0005634	nucleus
0.36	GO:0005840	ribosome

tr|T1EEQ7|T1EEQ7_HELRO
Uncharacterized protein
Search

PEPCK

0.47	Phosphoenolpyruvate carboxykinase GTP

0.73	GO:0019319	hexose biosynthetic process
0.71	GO:0006006	glucose metabolic process
0.50	GO:0016310	phosphorylation
0.34	GO:0009749	response to glucose
0.33	GO:0050801	ion homeostasis

0.83	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0016301	kinase activity
0.33	GO:0046872	metal ion binding

0.38	GO:0055120	striated muscle dense body
0.33	GO:0005829	cytosol
0.33	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

0.83

EC:4.1.1.32

GO:0004613

tr|T1EEQ8|T1EEQ8_HELRO
Uncharacterized protein
Search

FOXRED1

0.42	FAD-dependent oxidoreductase domain-containing protein 1

0.53	GO:0055114	oxidation-reduction process
0.51	GO:0032981	mitochondrial respiratory chain complex I assembly
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:2001141	regulation of RNA biosynthetic process
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression

0.54	GO:0016491	oxidoreductase activity
0.33	GO:0003677	DNA binding
0.32	GO:0046872	metal ion binding

0.50	GO:0005747	mitochondrial respiratory chain complex I
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.54

GO:0016491

tr|T1EEQ9|T1EEQ9_HELRO
Uncharacterized protein
Search

CCNE2

0.86

Cyclin E

0.76	GO:0000082	G1/S transition of mitotic cell cycle
0.67	GO:0051726	regulation of cell cycle
0.56	GO:0007129	synapsis
0.53	GO:0000723	telomere maintenance
0.52	GO:0045859	regulation of protein kinase activity
0.52	GO:1903827	regulation of cellular protein localization
0.52	GO:0006270	DNA replication initiation
0.44	GO:0000122	negative regulation of transcription by RNA polymerase II
0.44	GO:0016055	Wnt signaling pathway
0.40	GO:0006468	protein phosphorylation

0.55	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.46	GO:0019901	protein kinase binding
0.39	GO:0016301	kinase activity
0.35	GO:0050681	androgen receptor binding
0.34	GO:0003713	transcription coactivator activity
0.32	GO:0016779	nucleotidyltransferase activity
0.32	GO:0003723	RNA binding
0.32	GO:0003735	structural constituent of ribosome

0.61	GO:0005634	nucleus
0.56	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
0.41	GO:0043233	organelle lumen
0.38	GO:0044446	intracellular organelle part
0.34	GO:0005829	cytosol
0.31	GO:0005840	ribosome
0.30	GO:0016020	membrane

0.55

GO:0016538

tr|T1EER0|T1EER0_HELRO
Uncharacterized protein
Search

0.53	GO:0055114	oxidation-reduction process
0.35	GO:0009410	response to xenobiotic stimulus
0.35	GO:0044550	secondary metabolite biosynthetic process
0.34	GO:0007548	sex differentiation
0.34	GO:0016123	xanthophyll biosynthetic process
0.34	GO:0006694	steroid biosynthetic process
0.33	GO:0042343	indole glucosinolate metabolic process
0.33	GO:0043651	linoleic acid metabolic process
0.33	GO:0019373	epoxygenase P450 pathway
0.33	GO:0009820	alkaloid metabolic process

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.65	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.35	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity
0.33	GO:0008519	ammonium transmembrane transporter activity
0.33	GO:0004252	serine-type endopeptidase activity
0.32	GO:0003743	translation initiation factor activity

0.34	GO:0009941	chloroplast envelope
0.33	GO:0009570	chloroplast stroma
0.32	GO:0005789	endoplasmic reticulum membrane
0.32	GO:0031090	organelle membrane
0.30	GO:0016021	integral component of membrane

0.68

GO:0016705

tr|T1EER1|T1EER1_HELRO
Uncharacterized protein
Search

0.53	GO:0055114	oxidation-reduction process
0.51	GO:0042446	hormone biosynthetic process
0.51	GO:0006694	steroid biosynthetic process
0.50	GO:0042448	progesterone metabolic process
0.48	GO:0070640	vitamin D3 metabolic process
0.47	GO:0008211	glucocorticoid metabolic process
0.47	GO:0042362	fat-soluble vitamin biosynthetic process
0.44	GO:0044108	cellular alcohol biosynthetic process
0.44	GO:0046173	polyol biosynthetic process
0.37	GO:0010164	response to cesium ion

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.66	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.51	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity
0.49	GO:0030343	vitamin D3 25-hydroxylase activity
0.36	GO:0019825	oxygen binding

0.45	GO:0043025	neuronal cell body
0.44	GO:0030424	axon
0.39	GO:0005739	mitochondrion
0.35	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0071203	WASH complex
0.33	GO:0031090	organelle membrane
0.30	GO:0016021	integral component of membrane

0.68

GO:0016705

tr|T1EER2|T1EER2_HELRO
Uncharacterized protein
Search

tr|T1EER3|T1EER3_HELRO
Uncharacterized protein
Search

EHD1

0.77	Receptor Mediated Endocytosis

0.77	GO:0032456	endocytic recycling
0.48	GO:1990255	subsynaptic reticulum organization
0.46	GO:0048052	R1/R6 cell differentiation
0.46	GO:0007291	sperm individualization
0.46	GO:0007474	imaginal disc-derived wing vein specification
0.46	GO:0008587	imaginal disc-derived wing margin morphogenesis
0.45	GO:0042670	retinal cone cell differentiation
0.45	GO:0045466	R7 cell differentiation
0.44	GO:0048477	oogenesis
0.43	GO:0060990	lipid tube assembly involved in organelle fission

0.66	GO:0005509	calcium ion binding
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0019904	protein domain specific binding
0.36	GO:0016887	ATPase activity

0.47	GO:0071212	subsynaptic reticulum
0.41	GO:0055037	recycling endosome
0.36	GO:0010008	endosome membrane

0.36

GO:0016887

tr|T1EER4|T1EER4_HELRO
Uncharacterized protein
Search

0.17	Pantothenate kinase (Fragment)

0.75	GO:0015937	coenzyme A biosynthetic process
0.57	GO:0016310	phosphorylation

0.79	GO:0004594	pantothenate kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.30

GO:0016020

membrane

0.79

EC:2.7.1.33

GO:0004594

tr|T1EER5|T1EER5_HELRO
Uncharacterized protein
Search

0.37	GO:0030198	extracellular matrix organization
0.37	GO:0071230	cellular response to amino acid stimulus
0.36	GO:0060414	aorta smooth muscle tissue morphogenesis
0.36	GO:0007167	enzyme linked receptor protein signaling pathway
0.36	GO:2001223	negative regulation of neuron migration
0.36	GO:0007160	cell-matrix adhesion
0.35	GO:0001558	regulation of cell growth
0.35	GO:0035025	positive regulation of Rho protein signal transduction
0.35	GO:0021987	cerebral cortex development
0.35	GO:0018149	peptide cross-linking

0.51	GO:0005201	extracellular matrix structural constituent
0.50	GO:0042302	structural constituent of cuticle
0.49	GO:0005509	calcium ion binding
0.37	GO:0019838	growth factor binding
0.35	GO:0046332	SMAD binding
0.35	GO:0005178	integrin binding
0.35	GO:0002020	protease binding
0.33	GO:0005044	scavenger receptor activity
0.33	GO:0016853	isomerase activity
0.33	GO:0004222	metalloendopeptidase activity

0.64	GO:0005581	collagen trimer
0.42	GO:0005578	proteinaceous extracellular matrix
0.42	GO:0044420	extracellular matrix component
0.35	GO:0099081	supramolecular polymer
0.34	GO:0005615	extracellular space
0.33	GO:0009277	fungal-type cell wall
0.30	GO:0016020	membrane

0.33

GO:0016853

tr|T1EER6|T1EER6_HELRO
Uncharacterized protein
Search

0.40	GO:0006351	transcription, DNA-templated
0.40	GO:2001141	regulation of RNA biosynthetic process
0.40	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.40	GO:0010468	regulation of gene expression
0.35	GO:0010631	epithelial cell migration
0.34	GO:0007390	germ-band shortening
0.34	GO:0007398	ectoderm development
0.34	GO:0007525	somatic muscle development
0.34	GO:0016925	protein sumoylation
0.34	GO:0048731	system development

0.51	GO:0003676	nucleic acid binding
0.39	GO:0046872	metal ion binding
0.34	GO:0019789	SUMO transferase activity
0.33	GO:0008047	enzyme activator activity
0.33	GO:0042979	ornithine decarboxylase regulator activity
0.33	GO:1990841	promoter-specific chromatin binding
0.33	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.32	GO:0016874	ligase activity
0.32	GO:0016301	kinase activity
0.32	GO:0042626	ATPase activity, coupled to transmembrane movement of substances

0.42	GO:0005634	nucleus
0.31	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.32

GO:0016874

tr|T1EER7|T1EER7_HELRO
Uncharacterized protein
Search

PNKP

0.83	Bifunctional polynucleotide phosphatase/kinase

0.55	GO:0016310	phosphorylation
0.51	GO:0098506	polynucleotide 3' dephosphorylation
0.49	GO:0098503	DNA 3' dephosphorylation
0.42	GO:0010836	negative regulation of protein ADP-ribosylation
0.41	GO:0042769	DNA damage response, detection of DNA damage
0.41	GO:0006281	DNA repair
0.41	GO:1904355	positive regulation of telomere capping
0.41	GO:0051973	positive regulation of telomerase activity
0.41	GO:0032212	positive regulation of telomere maintenance via telomerase
0.39	GO:0009117	nucleotide metabolic process

0.58	GO:0016301	kinase activity
0.51	GO:0046403	polynucleotide 3'-phosphatase activity
0.42	GO:0003690	double-stranded DNA binding
0.41	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.33	GO:0001104	RNA polymerase II transcription cofactor activity
0.33	GO:0008270	zinc ion binding

0.41	GO:0005634	nucleus
0.37	GO:0031974	membrane-enclosed lumen
0.36	GO:0043232	intracellular non-membrane-bounded organelle
0.36	GO:0044446	intracellular organelle part
0.32	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

0.51

EC:3.1.3.32

GO:0046403

tr|T1EER8|T1EER8_HELRO
Uncharacterized protein
Search

VAT1L

0.73	Synaptic vesicle membrane protein vat 1

0.53	GO:0055114	oxidation-reduction process
0.33	GO:0006278	RNA-dependent DNA biosynthetic process

0.59	GO:0008270	zinc ion binding
0.54	GO:0016491	oxidoreductase activity
0.33	GO:0003964	RNA-directed DNA polymerase activity
0.33	GO:0005515	protein binding

0.54

GO:0016491

tr|T1EER9|T1EER9_HELRO
Uncharacterized protein
Search

OSBP

0.52	Oxysterol-binding protein (Fragment)

0.74	GO:0006869	lipid transport
0.62	GO:0044128	positive regulation of growth of symbiont in host
0.53	GO:0015850	organic hydroxy compound transport
0.40	GO:0007286	spermatid development
0.33	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.32	GO:0007186	G-protein coupled receptor signaling pathway

0.58	GO:0015248	sterol transporter activity
0.56	GO:0070273	phosphatidylinositol-4-phosphate binding
0.53	GO:0019904	protein domain specific binding
0.40	GO:0015485	cholesterol binding
0.33	GO:0004984	olfactory receptor activity
0.33	GO:0004930	G-protein coupled receptor activity

0.54	GO:0048471	perinuclear region of cytoplasm
0.52	GO:0030054	cell junction
0.51	GO:0000139	Golgi membrane
0.51	GO:0005730	nucleolus
0.49	GO:0005654	nucleoplasm
0.49	GO:0005829	cytosol
0.41	GO:0097440	apical dendrite
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1EES0|T1EES0_HELRO
Glucose-6-phosphate isomerase
Search

0.53	Glucose-6-phosphate isomerase

0.73	GO:0019319	hexose biosynthetic process
0.71	GO:0006006	glucose metabolic process
0.71	GO:0006757	ATP generation from ADP
0.69	GO:0006090	pyruvate metabolic process
0.68	GO:0016052	carbohydrate catabolic process
0.67	GO:0019362	pyridine nucleotide metabolic process
0.44	GO:0051024	positive regulation of immunoglobulin secretion
0.43	GO:0001707	mesoderm formation
0.43	GO:0034101	erythrocyte homeostasis
0.42	GO:0042593	glucose homeostasis

0.78	GO:0004347	glucose-6-phosphate isomerase activity
0.41	GO:0031625	ubiquitin protein ligase binding
0.34	GO:0004584	dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity
0.34	GO:0005125	cytokine activity

0.43	GO:0060170	ciliary membrane
0.42	GO:0043209	myelin sheath
0.40	GO:0005615	extracellular space
0.39	GO:0005654	nucleoplasm
0.39	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.78

EC:5.3.1.9

GO:0004347

tr|T1EES1|T1EES1_HELRO
Uncharacterized protein
Search

tr|T1EES2|T1EES2_HELRO
Uncharacterized protein
Search

SLC41A1

0.70	Divalent cation transporter

0.61	GO:0098655	cation transmembrane transport
0.55	GO:0071286	cellular response to magnesium ion
0.53	GO:0010961	cellular magnesium ion homeostasis
0.51	GO:0070838	divalent metal ion transport
0.47	GO:0006814	sodium ion transport
0.43	GO:0098660	inorganic ion transmembrane transport
0.37	GO:0048793	pronephros development
0.36	GO:0043009	chordate embryonic development
0.34	GO:0006367	transcription initiation from RNA polymerase II promoter
0.33	GO:0006099	tricarboxylic acid cycle

0.61	GO:0008324	cation transmembrane transporter activity
0.48	GO:0099516	ion antiporter activity
0.45	GO:0015318	inorganic molecular entity transmembrane transporter activity
0.34	GO:0004449	isocitrate dehydrogenase (NAD+) activity
0.33	GO:0051287	NAD binding
0.33	GO:0000287	magnesium ion binding
0.33	GO:0005515	protein binding

0.50	GO:0016323	basolateral plasma membrane
0.42	GO:0043234	protein complex
0.33	GO:0016591	DNA-directed RNA polymerase II, holoenzyme
0.32	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.34

EC:1.1.1.41

GO:0004449

tr|T1EES3|T1EES3_HELRO
Uncharacterized protein
Search

0.54	Programmed cell death protein 6

0.41	GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway
0.40	GO:1902527	positive regulation of protein monoubiquitination
0.40	GO:0014029	neural crest formation
0.40	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
0.39	GO:0051898	negative regulation of protein kinase B signaling
0.39	GO:0001938	positive regulation of endothelial cell proliferation
0.39	GO:0010595	positive regulation of endothelial cell migration
0.39	GO:0048208	COPII vesicle coating
0.39	GO:0014032	neural crest cell development
0.39	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

0.70	GO:0005509	calcium ion binding
0.41	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.39	GO:0043495	protein membrane anchor
0.39	GO:0048306	calcium-dependent protein binding
0.38	GO:0060090	molecular adaptor activity
0.37	GO:0042803	protein homodimerization activity
0.33	GO:0000287	magnesium ion binding

0.39	GO:0070971	endoplasmic reticulum exit site
0.39	GO:0031463	Cul3-RING ubiquitin ligase complex
0.38	GO:0030127	COPII vesicle coat
0.37	GO:0000139	Golgi membrane
0.35	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

tr|T1EES4|T1EES4_HELRO
Uncharacterized protein
Search

0.38	DEAD (AspGluAlaAsp) box polypeptide 54 [Latimeria chalumnae]

0.46	GO:0010501	RNA secondary structure unwinding
0.46	GO:1903507	negative regulation of nucleic acid-templated transcription
0.43	GO:0006396	RNA processing
0.35	GO:0030520	intracellular estrogen receptor signaling pathway
0.34	GO:1902626	assembly of large subunit precursor of preribosome
0.33	GO:0010468	regulation of gene expression
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0042273	ribosomal large subunit biogenesis
0.33	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus

0.75	GO:0004004	ATP-dependent RNA helicase activity
0.57	GO:0003723	RNA binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0030331	estrogen receptor binding
0.50	GO:0003714	transcription corepressor activity
0.33	GO:0042802	identical protein binding
0.32	GO:0003677	DNA binding

0.59	GO:0005634	nucleus
0.47	GO:0031974	membrane-enclosed lumen
0.46	GO:0005794	Golgi apparatus
0.43	GO:0043232	intracellular non-membrane-bounded organelle
0.42	GO:0044446	intracellular organelle part
0.33	GO:0030687	preribosome, large subunit precursor
0.30	GO:0031224	intrinsic component of membrane

tr|T1EES5|T1EES5_HELRO
H/ACA ribonucleoprotein complex subunit
Search

GAR1

0.70	H/ACA ribonucleoprotein complex subunit

0.72	GO:0001522	pseudouridine synthesis
0.68	GO:0006364	rRNA processing
0.48	GO:0016074	snoRNA metabolic process
0.35	GO:0060216	definitive hemopoiesis
0.34	GO:0007601	visual perception
0.34	GO:0018298	protein-chromophore linkage
0.33	GO:0007186	G-protein coupled receptor signaling pathway

0.59	GO:0003723	RNA binding
0.34	GO:0009881	photoreceptor activity
0.33	GO:0004930	G-protein coupled receptor activity

0.84	GO:0031429	box H/ACA snoRNP complex
0.60	GO:0019013	viral nucleocapsid
0.42	GO:0090661	box H/ACA telomerase RNP complex
0.40	GO:0001650	fibrillar center
0.40	GO:0000784	nuclear chromosome, telomeric region
0.30	GO:0031224	intrinsic component of membrane

tr|T1EES6|T1EES6_HELRO
Uncharacterized protein
Search

0.52	DNA topoisomerase 2-binding protein 1

0.51	GO:1902165	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.50	GO:0060216	definitive hemopoiesis
0.49	GO:0010212	response to ionizing radiation
0.48	GO:0000076	DNA replication checkpoint
0.48	GO:0006974	cellular response to DNA damage stimulus
0.46	GO:0044818	mitotic G2/M transition checkpoint
0.46	GO:0044774	mitotic DNA integrity checkpoint
0.44	GO:0006270	DNA replication initiation
0.38	GO:0071165	GINS complex assembly
0.37	GO:0035563	positive regulation of chromatin binding

0.59	GO:0016853	isomerase activity
0.46	GO:0042802	identical protein binding
0.35	GO:0019900	kinase binding
0.35	GO:0003682	chromatin binding
0.34	GO:0003677	DNA binding

0.50	GO:0001673	male germ cell nucleus
0.50	GO:0016605	PML body
0.47	GO:0000794	condensed nuclear chromosome
0.46	GO:0015629	actin cytoskeleton
0.38	GO:0000922	spindle pole
0.37	GO:0005815	microtubule organizing center
0.36	GO:0005656	nuclear pre-replicative complex
0.35	GO:0000785	chromatin
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.59

GO:0016853

tr|T1EES7|T1EES7_HELRO
Uncharacterized protein
Search

0.65	Potassium voltage-gated channel protein Shaker

0.77	GO:0051260	protein homooligomerization
0.76	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport

0.78

GO:0005249

voltage-gated potassium channel activity

0.78	GO:0008076	voltage-gated potassium channel complex
0.35	GO:0032809	neuronal cell body membrane
0.35	GO:0032590	dendrite membrane
0.35	GO:0030673	axolemma

tr|T1EES8|T1EES8_HELRO
Uncharacterized protein
Search

IDE

0.85	Insulin degrading enzyme

0.61	GO:0006508	proteolysis
0.56	GO:1901143	insulin catabolic process
0.55	GO:0010815	bradykinin catabolic process
0.54	GO:0050435	amyloid-beta metabolic process
0.54	GO:0032461	positive regulation of protein oligomerization
0.53	GO:0010992	ubiquitin recycling
0.52	GO:0008340	determination of adult lifespan
0.49	GO:0051260	protein homooligomerization
0.47	GO:0044257	cellular protein catabolic process
0.46	GO:1990798	pancreas regeneration

0.70	GO:0004222	metalloendopeptidase activity
0.55	GO:0043559	insulin binding
0.55	GO:0140036	ubiquitin-dependent protein binding
0.54	GO:0046872	metal ion binding
0.48	GO:0042803	protein homodimerization activity
0.47	GO:0005102	receptor binding
0.40	GO:0032559	adenyl ribonucleotide binding
0.40	GO:0008144	drug binding
0.40	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0031626	beta-endorphin binding

0.48	GO:0005777	peroxisome
0.48	GO:0009986	cell surface
0.47	GO:0005615	extracellular space
0.45	GO:0005829	cytosol
0.42	GO:0005634	nucleus
0.42	GO:0005739	mitochondrion
0.37	GO:0031907	microbody lumen
0.36	GO:1905369	endopeptidase complex
0.34	GO:0043234	protein complex
0.34	GO:0005886	plasma membrane

0.70

GO:0004222

tr|T1EES9|T1EES9_HELRO
Uncharacterized protein
Search

0.66	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

0.76	GO:0043547	positive regulation of GTPase activity
0.51	GO:0033601	positive regulation of mammary gland epithelial cell proliferation
0.50	GO:0060749	mammary gland alveolus development
0.50	GO:0046427	positive regulation of JAK-STAT cascade
0.47	GO:0043066	negative regulation of apoptotic process
0.46	GO:0045944	positive regulation of transcription by RNA polymerase II
0.42	GO:0007165	signal transduction
0.39	GO:1901215	negative regulation of neuron death
0.39	GO:0043523	regulation of neuron apoptotic process
0.39	GO:1901099	negative regulation of signal transduction in absence of ligand

0.76	GO:0005096	GTPase activator activity
0.63	GO:0003924	GTPase activity
0.61	GO:0032550	purine ribonucleoside binding
0.61	GO:0019001	guanyl nucleotide binding
0.51	GO:0032555	purine ribonucleotide binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0046872	metal ion binding
0.38	GO:0030295	protein kinase activator activity
0.37	GO:0019901	protein kinase binding
0.35	GO:0035014	phosphatidylinositol 3-kinase regulator activity

0.46	GO:0005730	nucleolus
0.42	GO:0005739	mitochondrion
0.36	GO:0031982	vesicle
0.36	GO:0043230	extracellular organelle
0.35	GO:0005615	extracellular space
0.34	GO:0005829	cytosol
0.33	GO:0012505	endomembrane system
0.30	GO:0016020	membrane

tr|T1EET0|T1EET0_HELRO
Uncharacterized protein
Search

0.82	Plexin domain-containing protein 1

0.43	GO:0001525	angiogenesis
0.34	GO:0043401	steroid hormone mediated signaling pathway
0.32	GO:0006351	transcription, DNA-templated
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:0010468	regulation of gene expression

0.33

GO:0005515

protein binding

0.36	GO:0070062	extracellular exosome
0.34	GO:0043235	receptor complex
0.33	GO:0005886	plasma membrane
0.32	GO:0005634	nucleus
0.32	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

tr|T1EET1|T1EET1_HELRO
Uncharacterized protein
Search

EXOC5

0.70	Exocyst complex component

0.80	GO:0048278	vesicle docking
0.77	GO:0006887	exocytosis
0.45	GO:0006893	Golgi to plasma membrane transport
0.42	GO:0032402	melanosome transport
0.42	GO:0048793	pronephros development
0.42	GO:0045494	photoreceptor cell maintenance
0.41	GO:0042461	photoreceptor cell development
0.41	GO:0007368	determination of left/right symmetry
0.41	GO:0060041	retina development in camera-type eye
0.41	GO:0060271	cilium assembly

0.49	GO:0017160	Ral GTPase binding
0.48	GO:0047485	protein N-terminus binding
0.36	GO:0005267	potassium channel activity
0.34	GO:0046982	protein heterodimerization activity
0.34	GO:0008270	zinc ion binding
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.79	GO:0000145	exocyst
0.37	GO:0030496	midbody
0.35	GO:0005829	cytosol
0.35	GO:0097546	ciliary base
0.34	GO:0097731	9+0 non-motile cilium
0.33	GO:0005634	nucleus
0.30	GO:0044425	membrane part

tr|T1EET2|T1EET2_HELRO
Uncharacterized protein
Search

0.65	GO:0009451	RNA modification
0.64	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.66	GO:0004519	endonuclease activity
0.59	GO:0003723	RNA binding

0.61

GO:0005739

mitochondrion

tr|T1EET3|T1EET3_HELRO
Uncharacterized protein
Search

TOM1

0.81	Target of Myb protein 1

0.69	GO:0006886	intracellular protein transport
0.35	GO:0045839	negative regulation of mitotic nuclear division
0.34	GO:0043312	neutrophil degranulation
0.33	GO:0016197	endosomal transport
0.33	GO:0007165	signal transduction
0.33	GO:0006897	endocytosis
0.30	GO:0008152	metabolic process

0.45	GO:0030276	clathrin binding
0.36	GO:0008410	CoA-transferase activity
0.35	GO:0019901	protein kinase binding
0.32	GO:0003677	DNA binding

0.45	GO:0005622	intracellular
0.42	GO:0031982	vesicle
0.41	GO:0012505	endomembrane system
0.35	GO:0043230	extracellular organelle
0.34	GO:0005615	extracellular space
0.33	GO:0098805	whole membrane
0.33	GO:0098588	bounding membrane of organelle
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.36

EC:2.8.3

GO:0008410

tr|T1EET4|T1EET4_HELRO
Uncharacterized protein
Search

ACADS

0.30	Short-chain specific acyl-CoA dehydrogenase

0.53	GO:0055114	oxidation-reduction process
0.48	GO:0009062	fatty acid catabolic process
0.46	GO:0030258	lipid modification
0.36	GO:0006508	proteolysis
0.34	GO:0019605	butyrate metabolic process
0.34	GO:0051384	response to glucocorticoid
0.34	GO:0051289	protein homotetramerization
0.34	GO:0042594	response to starvation
0.33	GO:0006468	protein phosphorylation

0.75	GO:0003995	acyl-CoA dehydrogenase activity
0.66	GO:0050660	flavin adenine dinucleotide binding
0.39	GO:0004085	butyryl-CoA dehydrogenase activity
0.39	GO:0008235	metalloexopeptidase activity
0.38	GO:0030145	manganese ion binding
0.38	GO:0004177	aminopeptidase activity
0.35	GO:0043958	acryloyl-CoA reductase activity
0.34	GO:0000062	fatty-acyl-CoA binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding

0.45	GO:0005654	nucleoplasm
0.42	GO:0005739	mitochondrion
0.33	GO:0031967	organelle envelope
0.33	GO:0031090	organelle membrane

0.75	EC:1.3.99.3	GO:0003995
0.39	KEGG:R01178	GO:0004085

tr|T1EET5|T1EET5_HELRO
Uncharacterized protein
Search

CSNK1G3

0.73	Casein kinase I

0.63	GO:0006468	protein phosphorylation
0.54	GO:0018209	peptidyl-serine modification
0.47	GO:0016055	Wnt signaling pathway
0.44	GO:0006897	endocytosis
0.43	GO:0008360	regulation of cell shape
0.36	GO:0000186	activation of MAPKK activity
0.34	GO:0035556	intracellular signal transduction

0.70	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0051219	phosphoprotein binding
0.35	GO:0042277	peptide binding
0.35	GO:0005057	signal transducer activity, downstream of receptor
0.34	GO:0000287	magnesium ion binding

0.41	GO:0005634	nucleus
0.37	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.70

GO:0004674

tr|T1EET6|T1EET6_HELRO
Uncharacterized protein
Search

AP2A1

0.72	AP-2 complex subunit alpha

0.72	GO:0072583	clathrin-dependent endocytosis
0.69	GO:0006886	intracellular protein transport
0.51	GO:1900126	negative regulation of hyaluronan biosynthetic process
0.44	GO:0060218	hematopoietic stem cell differentiation
0.43	GO:0009950	dorsal/ventral axis specification
0.40	GO:0048260	positive regulation of receptor-mediated endocytosis
0.39	GO:0010976	positive regulation of neuron projection development
0.36	GO:0032802	low-density lipoprotein particle receptor catabolic process
0.36	GO:0034383	low-density lipoprotein particle clearance
0.36	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

0.85	GO:0035615	clathrin adaptor activity
0.68	GO:0008565	protein transporter activity
0.49	GO:0050750	low-density lipoprotein particle receptor binding
0.46	GO:0019901	protein kinase binding
0.39	GO:0008022	protein C-terminus binding
0.38	GO:0032403	protein complex binding
0.33	GO:0032794	GTPase activating protein binding

0.79	GO:0030131	clathrin adaptor complex
0.78	GO:0005905	clathrin-coated pit
0.49	GO:0032433	filopodium tip
0.39	GO:0016323	basolateral plasma membrane
0.39	GO:0016324	apical plasma membrane
0.38	GO:0030136	clathrin-coated vesicle
0.38	GO:0005794	Golgi apparatus
0.36	GO:0036020	endolysosome membrane
0.35	GO:0030139	endocytic vesicle
0.35	GO:0030141	secretory granule

tr|T1EET7|T1EET7_HELRO
Uncharacterized protein
Search

0.54	High affinity cationic amino acid transporter

0.55	GO:0055085	transmembrane transport
0.49	GO:0006865	amino acid transport
0.36	GO:0001654	eye development
0.35	GO:0055088	lipid homeostasis
0.34	GO:0040007	growth

0.57

GO:0022857

transmembrane transporter activity

0.32	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

tr|T1EET8|T1EET8_HELRO
Uncharacterized protein
Search

0.10	Zinc finger, MYND-type containing 11

0.50	GO:0046329	negative regulation of JNK cascade
0.49	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
0.49	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
0.47	GO:0030514	negative regulation of BMP signaling pathway
0.46	GO:0051607	defense response to virus
0.43	GO:1903507	negative regulation of nucleic acid-templated transcription
0.41	GO:0034243	regulation of transcription elongation from RNA polymerase II promoter
0.40	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
0.40	GO:0010629	negative regulation of gene expression
0.35	GO:0016569	covalent chromatin modification

0.53	GO:0046872	metal ion binding
0.50	GO:0042393	histone binding
0.49	GO:0140034	methylation-dependent protein binding
0.47	GO:0003690	double-stranded DNA binding
0.44	GO:0003712	transcription cofactor activity
0.42	GO:0001012	RNA polymerase II regulatory region DNA binding
0.42	GO:0003682	chromatin binding
0.39	GO:0043565	sequence-specific DNA binding

0.44	GO:0005654	nucleoplasm
0.34	GO:0005694	chromosome
0.30	GO:0031224	intrinsic component of membrane

tr|T1EET9|T1EET9_HELRO
Uncharacterized protein
Search

0.68	Collagen, type IX, alpha 2

0.45	GO:0030198	extracellular matrix organization
0.43	GO:0007167	enzyme linked receptor protein signaling pathway
0.43	GO:0048513	animal organ development
0.43	GO:0038065	collagen-activated signaling pathway
0.42	GO:0072359	circulatory system development
0.42	GO:0009653	anatomical structure morphogenesis
0.41	GO:0097435	supramolecular fiber organization
0.41	GO:0007528	neuromuscular junction development
0.41	GO:0009888	tissue development
0.41	GO:0071230	cellular response to amino acid stimulus

0.75	GO:0005201	extracellular matrix structural constituent
0.42	GO:0048407	platelet-derived growth factor binding
0.40	GO:0046332	SMAD binding
0.40	GO:0002020	protease binding
0.39	GO:0005178	integrin binding
0.38	GO:0042302	structural constituent of cuticle
0.36	GO:0030674	protein binding, bridging
0.36	GO:0008201	heparin binding
0.35	GO:0042802	identical protein binding
0.35	GO:0043394	proteoglycan binding

0.68	GO:0005581	collagen trimer
0.59	GO:0044420	extracellular matrix component
0.56	GO:0005578	proteinaceous extracellular matrix
0.45	GO:0099080	supramolecular complex
0.41	GO:0005615	extracellular space
0.41	GO:0031594	neuromuscular junction
0.36	GO:0019867	outer membrane
0.36	GO:0005783	endoplasmic reticulum
0.33	GO:0042383	sarcolemma
0.33	GO:0043235	receptor complex

0.32

GO:0004181

tr|T1EEU0|T1EEU0_HELRO
Uncharacterized protein
Search

tr|T1EEU1|T1EEU1_HELRO
Amidophosphoribosyltransferase
Search

PPAT

0.54	Phosphoribosyl pyrophosphate amidotransferase proprotein variant (Fragment)

0.76	GO:0009113	purine nucleobase biosynthetic process
0.66	GO:0009116	nucleoside metabolic process

0.80	GO:0004044	amidophosphoribosyltransferase activity
0.64	GO:0051540	metal cluster binding
0.56	GO:0048037	cofactor binding
0.54	GO:0046872	metal ion binding

0.80	EC:2.4.2.14	GO:0004044
0.80	KEGG:R01072	GO:0004044

tr|T1EEU2|T1EEU2_HELRO
Uncharacterized protein
Search

VCPKMT

0.86	Valosin containing protein lysine methyltransferase

0.58	GO:0032259	methylation
0.34	GO:0006508	proteolysis

0.58	GO:0008168	methyltransferase activity
0.35	GO:0008237	metallopeptidase activity
0.35	GO:0008270	zinc ion binding

0.30

GO:0031224

intrinsic component of membrane

0.58

GO:0008168

tr|T1EEU3|T1EEU3_HELRO
Uncharacterized protein
Search

0.66	Troponin T

0.78	GO:0006937	regulation of muscle contraction
0.38	GO:1905905	pharyngeal gland morphogenesis
0.37	GO:0060465	pharynx development
0.37	GO:0035023	regulation of Rho protein signal transduction
0.37	GO:0006413	translational initiation
0.37	GO:0002119	nematode larval development
0.36	GO:0006233	dTDP biosynthetic process
0.36	GO:0006235	dTTP biosynthetic process
0.36	GO:0065009	regulation of molecular function
0.36	GO:0032467	positive regulation of cytokinesis

0.37	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.37	GO:0003743	translation initiation factor activity
0.36	GO:0004798	thymidylate kinase activity
0.36	GO:0005525	GTP binding
0.36	GO:0003924	GTPase activity
0.36	GO:0005509	calcium ion binding
0.35	GO:0003689	DNA clamp loader activity
0.35	GO:0000822	inositol hexakisphosphate binding
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0031369	translation initiation factor binding

0.78	GO:0005861	troponin complex
0.35	GO:0005663	DNA replication factor C complex
0.35	GO:0000922	spindle pole
0.35	GO:0005813	centrosome
0.35	GO:0009898	cytoplasmic side of plasma membrane
0.34	GO:0005874	microtubule
0.34	GO:0044614	nuclear pore cytoplasmic filaments
0.34	GO:0032153	cell division site
0.34	GO:0017119	Golgi transport complex
0.34	GO:0071540	eukaryotic translation initiation factor 3 complex, eIF3e

0.36	EC:2.7.4.9	GO:0004798
0.34	KEGG:R03876	GO:0004842

tr|T1EEU4|T1EEU4_HELRO
Uncharacterized protein
Search

0.56	IQ motif and SEC7 domain-containing protein 1

0.81	GO:0032012	regulation of ARF protein signal transduction
0.66	GO:0065009	regulation of molecular function
0.46	GO:0007520	myoblast fusion
0.45	GO:0030036	actin cytoskeleton organization
0.43	GO:0007417	central nervous system development
0.40	GO:0046579	positive regulation of Ras protein signal transduction
0.34	GO:1900454	positive regulation of long term synaptic depression
0.34	GO:0051968	positive regulation of synaptic transmission, glutamatergic
0.34	GO:0001745	compound eye morphogenesis
0.32	GO:0006468	protein phosphorylation

0.82	GO:0005086	ARF guanyl-nucleotide exchange factor activity
0.44	GO:0045296	cadherin binding
0.33	GO:0005096	GTPase activator activity
0.33	GO:0004674	protein serine/threonine kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.38	GO:0000139	Golgi membrane
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0004674

tr|T1EEU5|T1EEU5_HELRO
Uncharacterized protein
Search

0.66	Sorting nexin

0.72	GO:0000281	mitotic cytokinesis
0.63	GO:0006897	endocytosis
0.63	GO:0015031	protein transport
0.61	GO:0046907	intracellular transport
0.61	GO:0034613	cellular protein localization
0.43	GO:0036089	cleavage furrow formation
0.42	GO:0097320	plasma membrane tubulation
0.41	GO:0051044	positive regulation of membrane protein ectodomain proteolysis
0.40	GO:0060988	lipid tube assembly
0.40	GO:0032461	positive regulation of protein oligomerization

0.76	GO:0035091	phosphatidylinositol binding
0.40	GO:0071933	Arp2/3 complex binding
0.39	GO:0045296	cadherin binding
0.39	GO:0031625	ubiquitin protein ligase binding
0.38	GO:0042802	identical protein binding
0.37	GO:0046983	protein dimerization activity
0.32	GO:0005085	guanyl-nucleotide exchange factor activity

0.65	GO:0030659	cytoplasmic vesicle membrane
0.40	GO:0019898	extrinsic component of membrane
0.39	GO:0005802	trans-Golgi network
0.39	GO:0030136	clathrin-coated vesicle
0.38	GO:0005829	cytosol
0.38	GO:0009898	cytoplasmic side of plasma membrane
0.32	GO:0005768	endosome
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEU6|T1EEU6_HELRO
Uncharacterized protein
Search

DOCK2

0.58	Dedicator of cytokinesis protein 1

0.73	GO:0007264	small GTPase mediated signal transduction
0.64	GO:0065009	regulation of molecular function
0.61	GO:0007010	cytoskeleton organization
0.56	GO:0030029	actin filament-based process
0.56	GO:0002277	myeloid dendritic cell activation involved in immune response
0.55	GO:0001768	establishment of T cell polarity
0.55	GO:0001766	membrane raft polarization
0.55	GO:0046633	alpha-beta T cell proliferation
0.54	GO:0044351	macropinocytosis
0.54	GO:0001771	immunological synapse formation

0.72	GO:0005085	guanyl-nucleotide exchange factor activity
0.58	GO:0005096	GTPase activator activity
0.55	GO:0042608	T cell receptor binding
0.52	GO:0048365	Rac GTPase binding
0.32	GO:0003676	nucleic acid binding

0.44	GO:0005622	intracellular
0.37	GO:0005886	plasma membrane
0.35	GO:0043233	organelle lumen
0.35	GO:0012505	endomembrane system
0.34	GO:0070062	extracellular exosome
0.34	GO:0043228	non-membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

tr|T1EEU7|T1EEU7_HELRO
Uncharacterized protein
Search

RAE1

0.89	mRNA export factor

0.81	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.76	GO:0051028	mRNA transport
0.75	GO:0006405	RNA export from nucleus
0.54	GO:0010467	gene expression
0.53	GO:0060236	regulation of mitotic spindle organization
0.49	GO:0071407	cellular response to organic cyclic compound
0.49	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
0.46	GO:0006606	protein import into nucleus
0.44	GO:0045886	negative regulation of synaptic growth at neuromuscular junction
0.44	GO:0007141	male meiosis I

0.47	GO:0043130	ubiquitin binding
0.43	GO:0003723	RNA binding
0.35	GO:0008017	microtubule binding
0.35	GO:0016905	myosin heavy chain kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0003677	DNA binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.54	GO:0097431	mitotic spindle pole
0.54	GO:0005643	nuclear pore
0.51	GO:0001650	fibrillar center
0.45	GO:0016006	Nebenkern
0.43	GO:0036126	sperm flagellum
0.33	GO:0044215	other organism
0.32	GO:0005694	chromosome

0.35

GO:0016905

tr|T1EEU8|T1EEU8_HELRO
Uncharacterized protein
Search

0.54	Adenosylhomocysteinase

0.72	GO:0006730	one-carbon metabolic process
0.43	GO:0046498	S-adenosylhomocysteine metabolic process
0.41	GO:0046439	L-cysteine metabolic process
0.41	GO:0046500	S-adenosylmethionine metabolic process
0.40	GO:0006555	methionine metabolic process
0.39	GO:0046130	purine ribonucleoside catabolic process
0.38	GO:0044273	sulfur compound catabolic process
0.38	GO:0042219	cellular modified amino acid catabolic process
0.38	GO:0051187	cofactor catabolic process
0.37	GO:1901606	alpha-amino acid catabolic process

0.80	GO:0004013	adenosylhomocysteinase activity
0.37	GO:0051287	NAD binding
0.33	GO:0005515	protein binding

0.39	GO:0005829	cytosol
0.35	GO:0043005	neuron projection
0.33	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane

0.80

EC:3.3.1.1

GO:0004013

tr|T1EEU9|T1EEU9_HELRO
Uncharacterized protein
Search

0.70	rRNA 2'-O-methyltransferase fibrillarin

0.69	GO:0006364	rRNA processing
0.66	GO:0008033	tRNA processing
0.63	GO:0032259	methylation
0.58	GO:0000494	box C/D snoRNA 3'-end processing
0.52	GO:0006356	regulation of transcription by RNA polymerase I
0.51	GO:0016570	histone modification
0.50	GO:0008213	protein alkylation
0.46	GO:0009451	RNA modification
0.37	GO:0045727	positive regulation of translation
0.34	GO:0043043	peptide biosynthetic process

0.63	GO:0008168	methyltransferase activity
0.59	GO:0003723	RNA binding
0.49	GO:0140102	catalytic activity, acting on a rRNA
0.43	GO:0140096	catalytic activity, acting on a protein
0.35	GO:0003735	structural constituent of ribosome
0.34	GO:0004418	hydroxymethylbilane synthase activity
0.33	GO:0051287	NAD binding
0.33	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

0.56	GO:0031428	box C/D snoRNP complex
0.53	GO:0032040	small-subunit processome
0.44	GO:0015030	Cajal body
0.34	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.63	EC:2.1.1	GO:0008168
0.34	KEGG:R00084	GO:0004418

tr|T1EEV0|T1EEV0_HELRO
RNA helicase
Search

DDX55

0.50	RNA helicase

0.47	GO:0010501	RNA secondary structure unwinding
0.33	GO:0007275	multicellular organism development

0.66	GO:0004386	helicase activity
0.58	GO:0003723	RNA binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0008186	RNA-dependent ATPase activity
0.40	GO:0140098	catalytic activity, acting on RNA
0.33	GO:0005515	protein binding

0.50	GO:0005730	nucleolus
0.45	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEV1|T1EEV1_HELRO
Uncharacterized protein
Search

KIF13A

0.76	NAD-dependent protein deacylase sirtuin-5, mitochondrial

0.74	GO:0007018	microtubule-based movement
0.67	GO:0099518	vesicle cytoskeletal trafficking
0.44	GO:0035459	cargo loading into vesicle
0.43	GO:0032438	melanosome organization
0.43	GO:0008333	endosome to lysosome transport
0.41	GO:0032465	regulation of cytokinesis
0.41	GO:0051294	establishment of spindle orientation
0.40	GO:0050803	regulation of synapse structure or activity
0.40	GO:0006886	intracellular protein transport
0.35	GO:0046168	glycerol-3-phosphate catabolic process

0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0042803	protein homodimerization activity
0.36	GO:0016887	ATPase activity
0.35	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity
0.35	GO:0051287	NAD binding
0.34	GO:0000213	tRNA-intron endonuclease activity

0.44	GO:0015630	microtubule cytoskeleton
0.44	GO:0044430	cytoskeletal part
0.44	GO:0005768	endosome
0.42	GO:0030496	midbody
0.40	GO:0044433	cytoplasmic vesicle part
0.40	GO:0099512	supramolecular fiber
0.40	GO:0098805	whole membrane
0.39	GO:0098588	bounding membrane of organelle
0.37	GO:0043234	protein complex
0.35	GO:0009331	glycerol-3-phosphate dehydrogenase complex

0.36	EC:3.6.1.3	GO:0016887
0.35	KEGG:R00842	GO:0004367

tr|T1EEV2|T1EEV2_HELRO
Uncharacterized protein
Search

AGL

0.55	Glycogen debranching enzyme

0.80	GO:0005980	glycogen catabolic process
0.76	GO:0005978	glycogen biosynthetic process
0.38	GO:0051384	response to glucocorticoid
0.37	GO:0007584	response to nutrient
0.35	GO:0043312	neutrophil degranulation

0.84	GO:0004135	amylo-alpha-1,6-glucosidase activity
0.80	GO:0004134	4-alpha-glucanotransferase activity
0.49	GO:0031593	polyubiquitin modification-dependent protein binding
0.47	GO:0001871	pattern binding
0.44	GO:0030246	carbohydrate binding
0.41	GO:0102500	beta-maltose 4-alpha-glucanotransferase activity

0.49	GO:0016234	inclusion body
0.41	GO:0005634	nucleus
0.38	GO:0016529	sarcoplasmic reticulum
0.35	GO:0043033	isoamylase complex
0.35	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0034774	secretory granule lumen
0.33	GO:0005829	cytosol
0.33	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.84

EC:3.2.1.33

GO:0004135

tr|T1EEV3|T1EEV3_HELRO
Uncharacterized protein
Search

0.62	GO:0007219	Notch signaling pathway
0.56	GO:0007275	multicellular organism development
0.55	GO:0030154	cell differentiation
0.53	GO:0050793	regulation of developmental process
0.47	GO:0060322	head development
0.47	GO:0008284	positive regulation of cell proliferation
0.47	GO:0000122	negative regulation of transcription by RNA polymerase II
0.46	GO:0048660	regulation of smooth muscle cell proliferation
0.46	GO:0048646	anatomical structure formation involved in morphogenesis
0.46	GO:0051241	negative regulation of multicellular organismal process

0.70	GO:0005509	calcium ion binding
0.50	GO:0004872	receptor activity
0.48	GO:0045296	cadherin binding
0.46	GO:0042802	identical protein binding
0.44	GO:0019899	enzyme binding
0.43	GO:0005112	Notch binding
0.40	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.39	GO:0031490	chromatin DNA binding
0.39	GO:0001047	core promoter binding
0.39	GO:0004857	enzyme inhibitor activity

0.50	GO:0043235	receptor complex
0.45	GO:0015629	actin cytoskeleton
0.45	GO:0005654	nucleoplasm
0.44	GO:0005829	cytosol
0.41	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex
0.41	GO:0009986	cell surface
0.40	GO:0005886	plasma membrane
0.39	GO:0045177	apical part of cell
0.39	GO:0005912	adherens junction
0.38	GO:0005783	endoplasmic reticulum

0.34

GO:0004725

tr|T1EEV4|T1EEV4_HELRO
Eukaryotic translation initiation factor 3 subunit C
Search

0.69	Eukaryotic translation initiation factor 3 subunit C

0.76	GO:0001731	formation of translation preinitiation complex
0.74	GO:0006446	regulation of translational initiation
0.34	GO:0016573	histone acetylation
0.33	GO:2001141	regulation of RNA biosynthetic process
0.32	GO:0006414	translational elongation

0.83	GO:0031369	translation initiation factor binding
0.73	GO:0003743	translation initiation factor activity
0.34	GO:0004402	histone acetyltransferase activity
0.33	GO:0046872	metal ion binding
0.32	GO:0003746	translation elongation factor activity

0.78	GO:0005852	eukaryotic translation initiation factor 3 complex
0.75	GO:0016282	eukaryotic 43S preinitiation complex
0.75	GO:0033290	eukaryotic 48S preinitiation complex
0.33	GO:0005829	cytosol

0.34

GO:0004402

tr|T1EEV5|T1EEV5_HELRO
Uncharacterized protein
Search

0.60	Serine/threonine-protein kinase ULK4 (Fragment)

0.63	GO:0006468	protein phosphorylation
0.52	GO:0090036	regulation of protein kinase C signaling
0.52	GO:1900744	regulation of p38MAPK cascade
0.52	GO:2001222	regulation of neuron migration
0.50	GO:0046328	regulation of JNK cascade
0.50	GO:0010975	regulation of neuron projection development
0.47	GO:0000226	microtubule cytoskeleton organization
0.35	GO:0002357	defense response to tumor cell
0.35	GO:0022038	corpus callosum development
0.35	GO:0003351	epithelial cilium movement

0.64	GO:0004672	protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0016004	phospholipase activator activity
0.34	GO:0043274	phospholipase binding
0.33	GO:0005509	calcium ion binding
0.33	GO:0000287	magnesium ion binding
0.32	GO:0004383	guanylate cyclase activity

0.33	GO:0043227	membrane-bounded organelle
0.33	GO:0042995	cell projection
0.33	GO:0097458	neuron part
0.33	GO:0043229	intracellular organelle
0.33	GO:0032279	asymmetric synapse
0.33	GO:0099572	postsynaptic specialization
0.32	GO:0005886	plasma membrane
0.32	GO:0044297	cell body
0.32	GO:0031974	membrane-enclosed lumen
0.32	GO:0008074	guanylate cyclase complex, soluble

0.32

GO:0004383

tr|T1EEV6|T1EEV6_HELRO
Uncharacterized protein
Search

0.38	GO:1903506	regulation of nucleic acid-templated transcription
0.38	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.38	GO:0010468	regulation of gene expression
0.38	GO:0006366	transcription by RNA polymerase II
0.37	GO:0051569	regulation of histone H3-K4 methylation
0.37	GO:1902680	positive regulation of RNA biosynthetic process
0.36	GO:0060712	spongiotrophoblast layer development
0.36	GO:1902679	negative regulation of RNA biosynthetic process
0.36	GO:0002244	hematopoietic progenitor cell differentiation
0.35	GO:0032259	methylation

0.51	GO:0003676	nucleic acid binding
0.40	GO:0008270	zinc ion binding
0.40	GO:0003700	DNA binding transcription factor activity
0.35	GO:0008168	methyltransferase activity

0.41	GO:0005634	nucleus
0.37	GO:0005813	centrosome
0.35	GO:0031974	membrane-enclosed lumen

0.35

GO:0008168

tr|T1EEV7|T1EEV7_HELRO
Uncharacterized protein
Search

0.53	Long-chain fatty acid transport protein 1

0.58	GO:0015908	fatty acid transport
0.56	GO:0001676	long-chain fatty acid metabolic process
0.41	GO:0033211	adiponectin-activated signaling pathway
0.41	GO:0031652	positive regulation of heat generation
0.40	GO:0071072	negative regulation of phospholipid biosynthetic process
0.40	GO:0006659	phosphatidylserine biosynthetic process
0.39	GO:0006656	phosphatidylcholine biosynthetic process
0.39	GO:0042760	very long-chain fatty acid catabolic process
0.39	GO:0032868	response to insulin
0.39	GO:0006654	phosphatidic acid biosynthetic process

0.61	GO:0031957	very long-chain fatty acid-CoA ligase activity
0.57	GO:0004467	long-chain fatty acid-CoA ligase activity
0.54	GO:0015245	fatty acid transmembrane transporter activity
0.38	GO:0042803	protein homodimerization activity
0.36	GO:0047747	cholate-CoA ligase activity
0.34	GO:0017057	6-phosphogluconolactonase activity
0.33	GO:1901265	nucleoside phosphate binding
0.32	GO:0036094	small molecule binding

0.39	GO:0005783	endoplasmic reticulum
0.39	GO:0031526	brush border membrane
0.39	GO:0005902	microvillus
0.37	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0005829	cytosol
0.36	GO:0031984	organelle subcompartment
0.35	GO:0005739	mitochondrion
0.34	GO:0005901	caveola
0.33	GO:0031410	cytoplasmic vesicle
0.33	GO:0019866	organelle inner membrane

0.57	EC:6.2.1.3	GO:0004467
0.34	KEGG:R02035	GO:0017057

tr|T1EEV8|T1EEV8_HELRO
Uncharacterized protein
Search

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.44	GO:0014019	neuroblast development
0.44	GO:0007400	neuroblast fate determination
0.43	GO:0010001	glial cell differentiation
0.43	GO:0007420	brain development
0.42	GO:1902680	positive regulation of RNA biosynthetic process
0.40	GO:1902679	negative regulation of RNA biosynthetic process
0.38	GO:0043282	pharyngeal muscle development

0.65	GO:0043565	sequence-specific DNA binding
0.41	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.40	GO:0008134	transcription factor binding
0.35	GO:0001047	core promoter binding
0.35	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding
0.34	GO:0003690	double-stranded DNA binding
0.34	GO:0001012	RNA polymerase II regulatory region DNA binding
0.33	GO:0019899	enzyme binding

0.61	GO:0005634	nucleus
0.33	GO:0005667	transcription factor complex
0.30	GO:0016020	membrane

tr|T1EEV9|T1EEV9_HELRO
Uncharacterized protein
Search

0.36	WD repeat-containing protein 5B

0.44	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.44	GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.44	GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.41	GO:0006468	protein phosphorylation
0.36	GO:0002098	tRNA wobble uridine modification
0.35	GO:0044355	clearance of foreign intracellular DNA
0.35	GO:0000272	polysaccharide catabolic process
0.35	GO:2000142	regulation of DNA-templated transcription, initiation
0.35	GO:0031124	mRNA 3'-end processing
0.35	GO:0006352	DNA-templated transcription, initiation

0.43	GO:0030515	snoRNA binding
0.41	GO:0004672	protein kinase activity
0.41	GO:0005509	calcium ion binding
0.40	GO:0043531	ADP binding
0.38	GO:0005524	ATP binding
0.36	GO:0004519	endonuclease activity
0.35	GO:0005515	protein binding
0.35	GO:0003677	DNA binding
0.35	GO:0016987	bacterial sigma factor activity
0.35	GO:0019888	protein phosphatase regulator activity

0.44	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome
0.42	GO:0032040	small-subunit processome
0.41	GO:1905369	endopeptidase complex
0.37	GO:0033588	Elongator holoenzyme complex
0.35	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
0.35	GO:0000159	protein phosphatase type 2A complex
0.35	GO:0000790	nuclear chromatin
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.34

GO:0016779

tr|T1EEW0|T1EEW0_HELRO
Uncharacterized protein
Search

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.48	GO:0021521	ventral spinal cord interneuron specification
0.47	GO:0009790	embryo development
0.45	GO:1902680	positive regulation of RNA biosynthetic process
0.43	GO:0042659	regulation of cell fate specification
0.43	GO:0009653	anatomical structure morphogenesis
0.42	GO:0051892	negative regulation of cardioblast differentiation
0.41	GO:0007512	adult heart development

0.65	GO:0043565	sequence-specific DNA binding
0.41	GO:0035326	enhancer binding
0.40	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.39	GO:0001012	RNA polymerase II regulatory region DNA binding
0.38	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.41	GO:0043233	organelle lumen
0.38	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

tr|T1EEW1|T1EEW1_HELRO
Delta-like protein
Search

0.64	GO:0007219	Notch signaling pathway
0.61	GO:0007275	multicellular organism development
0.57	GO:0030154	cell differentiation
0.54	GO:0050793	regulation of developmental process
0.46	GO:2001141	regulation of RNA biosynthetic process
0.46	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.45	GO:0010468	regulation of gene expression
0.36	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
0.36	GO:0007155	cell adhesion
0.35	GO:0072137	condensed mesenchymal cell proliferation

0.70	GO:0005509	calcium ion binding
0.50	GO:0004872	receptor activity
0.38	GO:0045296	cadherin binding
0.37	GO:0005201	extracellular matrix structural constituent
0.37	GO:0042802	identical protein binding
0.35	GO:0016504	peptidase activator activity
0.35	GO:0005540	hyaluronic acid binding
0.34	GO:0008270	zinc ion binding

0.38	GO:0005576	extracellular region
0.38	GO:0043235	receptor complex
0.37	GO:0015629	actin cytoskeleton
0.37	GO:0005654	nucleoplasm
0.36	GO:0005829	cytosol
0.34	GO:0045177	apical part of cell
0.34	GO:0043234	protein complex
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEW2|T1EEW2_HELRO
Uncharacterized protein
Search

TMED9

0.44	Transmembrane emp24 domain-containing protein eca

0.51	GO:0048205	COPI coating of Golgi vesicle
0.47	GO:0007030	Golgi organization
0.45	GO:0010638	positive regulation of organelle organization
0.36	GO:0034498	early endosome to Golgi transport
0.36	GO:0032527	protein exit from endoplasmic reticulum
0.34	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.34	GO:0006888	ER to Golgi vesicle-mediated transport
0.34	GO:0006432	phenylalanyl-tRNA aminoacylation
0.32	GO:0005975	carbohydrate metabolic process
0.32	GO:0055114	oxidation-reduction process

0.48	GO:0019905	syntaxin binding
0.34	GO:0004826	phenylalanine-tRNA ligase activity
0.33	GO:0000049	tRNA binding
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.33	GO:0016757	transferase activity, transferring glycosyl groups
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.33	GO:0004497	monooxygenase activity

0.67	GO:0005789	endoplasmic reticulum membrane
0.48	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.45	GO:0000139	Golgi membrane
0.35	GO:0031982	vesicle
0.35	GO:0043230	extracellular organelle
0.35	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane

0.34

EC:6.1.1.20

GO:0004826

tr|T1EEW3|T1EEW3_HELRO
Uncharacterized protein
Search

0.57	GO:0016310	phosphorylation
0.41	GO:0031031	positive regulation of septation initiation signaling
0.39	GO:0032147	activation of protein kinase activity
0.37	GO:0070727	cellular macromolecule localization
0.37	GO:0008104	protein localization
0.36	GO:0036211	protein modification process
0.35	GO:0044267	cellular protein metabolic process

0.60	GO:0016301	kinase activity
0.40	GO:0030295	protein kinase activator activity

0.41	GO:0034973	Sid2-Mob1 complex
0.40	GO:0031097	medial cortex
0.40	GO:0044732	mitotic spindle pole body
0.40	GO:0005935	cellular bud neck

tr|T1EEW4|T1EEW4_HELRO
Uncharacterized protein
Search

FARSB

0.44	Phenylalanyl-tRNA synthetase beta subunit

0.77	GO:0006432	phenylalanyl-tRNA aminoacylation
0.52	GO:0051290	protein heterotetramerization
0.40	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity
0.39	GO:0006414	translational elongation
0.36	GO:0006357	regulation of transcription by RNA polymerase II

0.76	GO:0004826	phenylalanine-tRNA ligase activity
0.64	GO:0000287	magnesium ion binding
0.59	GO:0003723	RNA binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0002161	aminoacyl-tRNA editing activity
0.37	GO:0001104	RNA polymerase II transcription cofactor activity
0.33	GO:0005515	protein binding

0.54	GO:0009328	phenylalanine-tRNA ligase complex
0.42	GO:0005853	eukaryotic translation elongation factor 1 complex
0.37	GO:0016592	mediator complex
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.76

EC:6.1.1.20

GO:0004826

tr|T1EEW5|T1EEW5_HELRO
Uncharacterized protein
Search

CUL1

0.57	Putative e3 ubiquitin ligase cullin 1 component

0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.52	GO:0006513	protein monoubiquitination
0.50	GO:0008283	cell proliferation
0.50	GO:0006915	apoptotic process
0.49	GO:0009887	animal organ morphogenesis
0.49	GO:0010498	proteasomal protein catabolic process
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0010265	SCF complex assembly
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway

0.79	GO:0031625	ubiquitin protein ligase binding
0.43	GO:0061630	ubiquitin protein ligase activity
0.37	GO:0016874	ligase activity
0.32	GO:0005484	SNAP receptor activity

0.74	GO:0031461	cullin-RING ubiquitin ligase complex
0.55	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex
0.35	GO:0005654	nucleoplasm
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.37

GO:0016874

tr|T1EEW6|T1EEW6_HELRO
Uncharacterized protein
Search

0.30	Short-chain dehydrogenase

0.44	GO:0010842	retina layer formation
0.44	GO:0009644	response to high light intensity
0.44	GO:0042462	eye photoreceptor cell development
0.43	GO:0055114	oxidation-reduction process
0.36	GO:0042572	retinol metabolic process
0.34	GO:0032259	methylation
0.34	GO:0043043	peptide biosynthetic process
0.34	GO:0044267	cellular protein metabolic process
0.33	GO:0010467	gene expression
0.33	GO:0009059	macromolecule biosynthetic process

0.44	GO:0016491	oxidoreductase activity
0.35	GO:0008168	methyltransferase activity
0.34	GO:0005507	copper ion binding

0.38	GO:0005739	mitochondrion
0.35	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane

0.44

GO:0016491

tr|T1EEW7|T1EEW7_HELRO
Uncharacterized protein
Search

0.10	LIM domain-binding protein 2 isoform X4

0.66	GO:0006357	regulation of transcription by RNA polymerase II
0.54	GO:0010669	epithelial structure maintenance
0.53	GO:0035019	somatic stem cell population maintenance
0.50	GO:0001942	hair follicle development
0.50	GO:0030334	regulation of cell migration
0.49	GO:0044089	positive regulation of cellular component biogenesis
0.49	GO:0045893	positive regulation of transcription, DNA-templated
0.49	GO:0043549	regulation of kinase activity
0.40	GO:0007563	regulation of eclosion
0.39	GO:0070983	dendrite guidance

0.82	GO:0030274	LIM domain binding
0.69	GO:0000989	transcription factor activity, transcription factor binding
0.47	GO:0019899	enzyme binding
0.38	GO:0001085	RNA polymerase II transcription factor binding

0.58	GO:0005634	nucleus
0.51	GO:0031252	cell leading edge
0.48	GO:0005667	transcription factor complex
0.46	GO:0031974	membrane-enclosed lumen
0.43	GO:0043232	intracellular non-membrane-bounded organelle
0.42	GO:0044446	intracellular organelle part
0.41	GO:0005886	plasma membrane

tr|T1EEW8|T1EEW8_HELRO
Receptor protein-tyrosine kinase
Search

0.46	Receptor protein-tyrosine kinase

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.76	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.60	GO:0023014	signal transduction by protein phosphorylation
0.57	GO:0035556	intracellular signal transduction
0.49	GO:0032285	non-myelinated axon ensheathment
0.49	GO:0048913	anterior lateral line nerve glial cell differentiation
0.49	GO:0048931	posterior lateral line nerve glial cell differentiation
0.49	GO:0048938	lateral line nerve glial cell morphogenesis involved in differentiation
0.48	GO:0007422	peripheral nervous system development
0.48	GO:0007507	heart development

0.80	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.77	GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0042802	identical protein binding
0.40	GO:0019838	growth factor binding
0.39	GO:0046983	protein dimerization activity
0.38	GO:0030296	protein tyrosine kinase activator activity

0.42	GO:0005622	intracellular
0.42	GO:0016323	basolateral plasma membrane
0.41	GO:0043235	receptor complex
0.40	GO:0016324	apical plasma membrane
0.38	GO:0016328	lateral plasma membrane
0.37	GO:0043209	myelin sheath
0.36	GO:0005615	extracellular space
0.36	GO:0012505	endomembrane system
0.36	GO:0031982	vesicle
0.36	GO:0098805	whole membrane

0.80

GO:0004714

tr|T1EEW9|T1EEW9_HELRO
Uncharacterized protein
Search

tr|T1EEX0|T1EEX0_HELRO
Uncharacterized protein
Search

0.76	GO:0016579	protein deubiquitination
0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.40	GO:1902476	chloride transmembrane transport
0.37	GO:0008587	imaginal disc-derived wing margin morphogenesis
0.37	GO:0016322	neuron remodeling
0.37	GO:0045880	positive regulation of smoothened signaling pathway
0.37	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.35	GO:0016570	histone modification
0.34	GO:0045721	negative regulation of gluconeogenesis
0.34	GO:0010498	proteasomal protein catabolic process

0.77	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.40	GO:0005247	voltage-gated chloride channel activity
0.37	GO:0008270	zinc ion binding
0.35	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.35	GO:0016746	transferase activity, transferring acyl groups
0.35	GO:0035091	phosphatidylinositol binding
0.34	GO:0008852	exodeoxyribonuclease I activity
0.34	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding

0.33	GO:0005737	cytoplasm
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.77

GO:0036459

tr|T1EEX1|T1EEX1_HELRO
Uncharacterized protein
Search

VPS18

0.87	Vacuolar protein sorting-associated protein 18

0.69	GO:0006886	intracellular protein transport
0.69	GO:0016192	vesicle-mediated transport
0.57	GO:0007041	lysosomal transport
0.56	GO:0007033	vacuole organization
0.56	GO:0007032	endosome organization
0.54	GO:0016197	endosomal transport
0.49	GO:0035542	regulation of SNARE complex assembly
0.48	GO:0060035	notochord cell development
0.47	GO:0007634	optokinetic behavior
0.47	GO:0048757	pigment granule maturation

0.52	GO:0019905	syntaxin binding
0.49	GO:0003779	actin binding
0.47	GO:0030674	protein binding, bridging
0.33	GO:0046872	metal ion binding
0.33	GO:0008408	3'-5' exonuclease activity
0.32	GO:0003676	nucleic acid binding

0.57	GO:0030897	HOPS complex
0.55	GO:0033263	CORVET complex
0.52	GO:0005884	actin filament
0.52	GO:0030123	AP-3 adaptor complex
0.52	GO:0005770	late endosome
0.51	GO:0005769	early endosome
0.51	GO:0005764	lysosome
0.37	GO:0098852	lytic vacuole membrane
0.36	GO:0010008	endosome membrane
0.36	GO:0005776	autophagosome

tr|T1EEX2|T1EEX2_HELRO
Uncharacterized protein
Search

MMAB

0.47	Cobalamin adenosyltransferase

0.36	GO:0006814	sodium ion transport
0.35	GO:0009236	cobalamin biosynthetic process
0.34	GO:0065009	regulation of molecular function
0.33	GO:0055085	transmembrane transport

0.53	GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity
0.46	GO:0031419	cobalamin binding
0.35	GO:0017080	sodium channel regulator activity
0.34	GO:0005515	protein binding
0.34	GO:0042030	ATPase inhibitor activity
0.33	GO:0005524	ATP binding
0.33	GO:0005215	transporter activity

0.41	GO:0005739	mitochondrion
0.35	GO:0001518	voltage-gated sodium channel complex
0.33	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part

0.53

EC:2.5.1.17

GO:0008817

tr|T1EEX3|T1EEX3_HELRO
Phosphoinositide phospholipase C
Search

PLCB4

0.53	Phosphoinositide phospholipase C

0.71	GO:0016042	lipid catabolic process
0.62	GO:0035556	intracellular signal transduction

0.81	GO:0004435	phosphatidylinositol phospholipase C activity
0.69	GO:0005509	calcium ion binding
0.63	GO:0004871	signal transducer activity
0.35	GO:0005515	protein binding

0.55	GO:0005790	smooth endoplasmic reticulum
0.52	GO:0014069	postsynaptic density
0.51	GO:0030425	dendrite
0.43	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.81	EC:3.1.4.11	GO:0004435
0.81	KEGG:R03435	GO:0004435

tr|T1EEX4|T1EEX4_HELRO
Uncharacterized protein
Search

TMEM165

0.46	Transmembrane protein 165

0.51	GO:0032472	Golgi calcium ion transport
0.50	GO:0035751	regulation of lysosomal lumen pH
0.50	GO:0006487	protein N-linked glycosylation
0.47	GO:0006874	cellular calcium ion homeostasis
0.44	GO:0060536	cartilage morphogenesis
0.43	GO:0048703	embryonic viscerocranium morphogenesis
0.43	GO:0002062	chondrocyte differentiation
0.43	GO:0001649	osteoblast differentiation
0.33	GO:0006629	lipid metabolic process
0.32	GO:0055114	oxidation-reduction process

0.33

GO:0016627

oxidoreductase activity, acting on the CH-CH group of donors

0.49	GO:0032588	trans-Golgi network membrane
0.47	GO:0005765	lysosomal membrane
0.46	GO:0010008	endosome membrane
0.34	GO:0005770	late endosome
0.34	GO:0005769	early endosome
0.30	GO:0016021	integral component of membrane

0.33

EC:1.3

GO:0016627

tr|T1EEX5|T1EEX5_HELRO
Uncharacterized protein
Search

0.39	Splicing factor

0.70	GO:0006397	mRNA processing
0.35	GO:0006779	porphyrin-containing compound biosynthetic process
0.33	GO:0055114	oxidation-reduction process

0.59	GO:0003723	RNA binding
0.36	GO:0004109	coproporphyrinogen oxidase activity
0.36	GO:0070403	NAD+ binding

0.61	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.36	EC:1.3.3.3	GO:0004109
0.36	KEGG:R03220	GO:0004109

tr|T1EEX6|T1EEX6_HELRO
Uncharacterized protein
Search

tr|T1EEX7|T1EEX7_HELRO
Sodium channel protein
Search

0.44	Sodium channel protein (Fragment)

0.77	GO:0034765	regulation of ion transmembrane transport
0.76	GO:0035725	sodium ion transmembrane transport
0.61	GO:0051930	regulation of sensory perception of pain
0.58	GO:0019233	sensory perception of pain
0.50	GO:0019228	neuronal action potential
0.50	GO:0086010	membrane depolarization during action potential
0.36	GO:0042493	response to drug
0.34	GO:0071805	potassium ion transmembrane transport

0.84	GO:0005248	voltage-gated sodium channel activity
0.74	GO:0022832	voltage-gated channel activity
0.72	GO:0022839	ion gated channel activity
0.71	GO:0008381	mechanosensitive ion channel activity
0.42	GO:0005509	calcium ion binding
0.37	GO:0005515	protein binding
0.34	GO:0005267	potassium channel activity

0.82	GO:0001518	voltage-gated sodium channel complex
0.64	GO:0044299	C-fiber
0.40	GO:0070062	extracellular exosome
0.35	GO:0008076	voltage-gated potassium channel complex

tr|T1EEX8|T1EEX8_HELRO
Uncharacterized protein
Search

0.57	Poly polymerase gamma

0.80	GO:0043631	RNA polyadenylation
0.76	GO:0031123	RNA 3'-end processing
0.42	GO:0006397	mRNA processing
0.34	GO:0031440	regulation of mRNA 3'-end processing

0.78	GO:0004652	polynucleotide adenylyltransferase activity
0.59	GO:0003723	RNA binding
0.50	GO:0046872	metal ion binding
0.50	GO:0032559	adenyl ribonucleotide binding
0.49	GO:0008144	drug binding
0.49	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005634	nucleus
0.43	GO:0031974	membrane-enclosed lumen
0.43	GO:0005829	cytosol
0.40	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.78

EC:2.7.7.19

GO:0004652

tr|T1EEX9|T1EEX9_HELRO
Uncharacterized protein
Search

MTHFD2

0.40	NAD-dependent methylenetetrahydrofolate

0.53	GO:0055114	oxidation-reduction process
0.47	GO:0006730	one-carbon metabolic process
0.46	GO:0046653	tetrahydrofolate metabolic process
0.42	GO:0009086	methionine biosynthetic process
0.42	GO:0000105	histidine biosynthetic process
0.40	GO:0006164	purine nucleotide biosynthetic process

0.79	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity
0.52	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity
0.51	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity
0.43	GO:0042301	phosphate ion binding
0.39	GO:0000287	magnesium ion binding
0.35	GO:0051287	NAD binding
0.35	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
0.33	GO:0005515	protein binding

0.41	GO:0005829	cytosol
0.40	GO:0005739	mitochondrion

0.79	EC:1.5.1.5	GO:0004488
0.79	KEGG:R01220	GO:0004488

tr|T1EEY0|T1EEY0_HELRO
Rhomboid-like protein
Search

0.56	Rhomboid-related protein 2

0.61	GO:0006508	proteolysis
0.42	GO:0051604	protein maturation

0.69	GO:0004252	serine-type endopeptidase activity
0.57	GO:0005509	calcium ion binding
0.33	GO:0008237	metallopeptidase activity
0.33	GO:0008270	zinc ion binding
0.33	GO:0046983	protein dimerization activity

0.38	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0004252

tr|T1EEY1|T1EEY1_HELRO
Uncharacterized protein
Search

FRYL

0.93	FRY like transcription coactivator

0.74	GO:1904428	negative regulation of tubulin deacetylation
0.67	GO:0031175	neuron projection development
0.66	GO:0090527	actin filament reorganization
0.64	GO:0000902	cell morphogenesis
0.58	GO:0043086	negative regulation of catalytic activity
0.46	GO:0007507	heart development
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0010468	regulation of gene expression

0.60

GO:0004857

enzyme inhibitor activity

0.68	GO:0030427	site of polarized growth
0.65	GO:0005938	cell cortex
0.42	GO:0000922	spindle pole
0.41	GO:0005815	microtubule organizing center
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEY2|T1EEY2_HELRO
Uncharacterized protein
Search

0.21	Serine/threonine protein kinase

0.63	GO:0006468	protein phosphorylation
0.40	GO:0032147	activation of protein kinase activity
0.39	GO:0031098	stress-activated protein kinase signaling cascade
0.38	GO:0043406	positive regulation of MAP kinase activity
0.38	GO:0051726	regulation of cell cycle
0.38	GO:0042981	regulation of apoptotic process
0.35	GO:0007623	circadian rhythm
0.33	GO:0051301	cell division
0.32	GO:0006520	cellular amino acid metabolic process

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0005057	signal transducer activity, downstream of receptor
0.33	GO:0001871	pattern binding
0.33	GO:0060089	molecular transducer activity
0.33	GO:0030246	carbohydrate binding
0.33	GO:0005509	calcium ion binding
0.32	GO:0019842	vitamin binding

0.36	GO:0005829	cytosol
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EEY3|T1EEY3_HELRO
Uncharacterized protein
Search

0.43	Calmodulin-alpha

0.37	GO:0051296	establishment of meiotic spindle orientation
0.36	GO:0043277	apoptotic cell clearance
0.36	GO:0051726	regulation of cell cycle
0.36	GO:0032879	regulation of localization
0.36	GO:0009792	embryo development ending in birth or egg hatching
0.35	GO:0016477	cell migration
0.35	GO:0043401	steroid hormone mediated signaling pathway
0.35	GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity
0.35	GO:0042981	regulation of apoptotic process
0.35	GO:0005513	detection of calcium ion

0.70	GO:0005509	calcium ion binding
0.36	GO:0003707	steroid hormone receptor activity
0.35	GO:0031418	L-ascorbic acid binding
0.35	GO:0031997	N-terminal myristoylation domain binding
0.35	GO:0031432	titin binding
0.35	GO:0019855	calcium channel inhibitor activity
0.35	GO:0008179	adenylate cyclase binding
0.35	GO:0072542	protein phosphatase activator activity
0.34	GO:0097718	disordered domain specific binding
0.34	GO:0044325	ion channel binding

0.36	GO:0005813	centrosome
0.36	GO:0005819	spindle
0.36	GO:0031965	nuclear membrane
0.34	GO:0030017	sarcomere
0.34	GO:0034704	calcium channel complex
0.33	GO:0005874	microtubule
0.33	GO:0071944	cell periphery
0.33	GO:1902494	catalytic complex
0.33	GO:0043234	protein complex

0.34

GO:0016705

tr|T1EEY4|T1EEY4_HELRO
Uncharacterized protein
Search

MFSD12

0.52	Major facilitator superfamily domain-containing protein 12

0.37	GO:0005765	lysosomal membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEY5|T1EEY5_HELRO
Uncharacterized protein
Search

YTHDC2

0.52	ATP-dependent RNA helicase

0.54	GO:0044829	positive regulation by host of viral genome replication
0.52	GO:0070555	response to interleukin-1
0.51	GO:0034612	response to tumor necrosis factor
0.41	GO:0006396	RNA processing

0.67	GO:0004386	helicase activity
0.56	GO:0003723	RNA binding
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0008186	RNA-dependent ATPase activity
0.49	GO:0070063	RNA polymerase binding
0.41	GO:0140098	catalytic activity, acting on RNA

0.46

GO:0005783

endoplasmic reticulum

tr|T1EEY6|T1EEY6_HELRO
Uncharacterized protein
Search

0.88	Mitochondrial ribosomal protein mrps25

0.38

GO:0032543

mitochondrial translation

0.40	GO:0003735	structural constituent of ribosome
0.35	GO:0005515	protein binding

0.60	GO:0005840	ribosome
0.40	GO:0005739	mitochondrion
0.36	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part

tr|T1EEY7|T1EEY7_HELRO
Uncharacterized protein
Search

PTPRFA

0.32	Receptor-type tyrosine-protein phosphatase alpha

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.43	GO:0048699	generation of neurons
0.43	GO:0048468	cell development
0.42	GO:1903034	regulation of response to wounding
0.42	GO:0120036	plasma membrane bounded cell projection organization
0.42	GO:0120035	regulation of plasma membrane bounded cell projection organization
0.41	GO:0051960	regulation of nervous system development
0.41	GO:0060284	regulation of cell development
0.41	GO:0032101	regulation of response to external stimulus
0.41	GO:0080135	regulation of cellular response to stress

0.75	GO:0004725	protein tyrosine phosphatase activity
0.42	GO:0035373	chondroitin sulfate proteoglycan binding
0.40	GO:0035374	chondroitin sulfate binding
0.39	GO:0008201	heparin binding
0.38	GO:0032403	protein complex binding
0.35	GO:0050254	rhodopsin kinase activity
0.35	GO:0016162	cellulose 1,4-beta-cellobiosidase activity

0.39	GO:0043025	neuronal cell body
0.39	GO:0043005	neuron projection
0.34	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.75

GO:0004725

tr|T1EEY8|T1EEY8_HELRO
Uncharacterized protein
Search

AQR

0.89	Aquarius intron-binding spliceosomal factor

0.75	GO:0000398	mRNA splicing, via spliceosome
0.34	GO:0006283	transcription-coupled nucleotide-excision repair

0.46	GO:0003723	RNA binding
0.33	GO:0005515	protein binding

0.76	GO:0005681	spliceosomal complex
0.49	GO:1902494	catalytic complex
0.47	GO:0005654	nucleoplasm
0.30	GO:0016021	integral component of membrane

tr|T1EEY9|T1EEY9_HELRO
Uncharacterized protein
Search

0.78	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

0.74	GO:0043547	positive regulation of GTPase activity
0.47	GO:0007165	signal transduction
0.43	GO:0072375	medium-term memory
0.37	GO:0033601	positive regulation of mammary gland epithelial cell proliferation
0.37	GO:0060749	mammary gland alveolus development
0.36	GO:0046427	positive regulation of JAK-STAT cascade
0.36	GO:0043066	negative regulation of apoptotic process
0.35	GO:0045944	positive regulation of transcription by RNA polymerase II
0.33	GO:0015031	protein transport

0.74	GO:0005096	GTPase activator activity
0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0046872	metal ion binding
0.41	GO:0005543	phospholipid binding

0.37	GO:0005730	nucleolus
0.35	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

tr|T1EEZ0|T1EEZ0_HELRO
Uncharacterized protein
Search

0.19	Matrix metalloproteinase-9

0.61	GO:0006508	proteolysis
0.57	GO:0030574	collagen catabolic process
0.54	GO:0050900	leukocyte migration
0.54	GO:0001503	ossification
0.47	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
0.46	GO:1900122	positive regulation of receptor binding
0.46	GO:0051549	positive regulation of keratinocyte migration
0.46	GO:1904707	positive regulation of vascular smooth muscle cell proliferation
0.46	GO:0090200	positive regulation of release of cytochrome c from mitochondria
0.46	GO:0007566	embryo implantation

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.42	GO:0042802	identical protein binding
0.36	GO:0005518	collagen binding
0.35	GO:0001047	core promoter binding
0.35	GO:0003975	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
0.35	GO:0005509	calcium ion binding
0.34	GO:0004252	serine-type endopeptidase activity
0.34	GO:0008963	phospho-N-acetylmuramoyl-pentapeptide-transferase activity
0.34	GO:0001968	fibronectin binding

0.74	GO:0031012	extracellular matrix
0.43	GO:0005615	extracellular space
0.34	GO:1903561	extracellular vesicle
0.34	GO:1904724	tertiary granule lumen
0.34	GO:1904813	ficolin-1-rich granule lumen
0.33	GO:0005634	nucleus
0.32	GO:0043234	protein complex
0.30	GO:0044425	membrane part

0.70

GO:0004222

tr|T1EEZ1|T1EEZ1_HELRO
Uncharacterized protein
Search

0.41	Novel protein containing trypsin domain

0.61	GO:0006508	proteolysis
0.40	GO:0007596	blood coagulation
0.33	GO:0006898	receptor-mediated endocytosis
0.33	GO:0032259	methylation
0.32	GO:0006429	leucyl-tRNA aminoacylation
0.32	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity

0.69	GO:0004252	serine-type endopeptidase activity
0.36	GO:0005509	calcium ion binding
0.33	GO:0005044	scavenger receptor activity
0.33	GO:0008168	methyltransferase activity
0.32	GO:0004823	leucine-tRNA ligase activity
0.32	GO:0002161	aminoacyl-tRNA editing activity
0.31	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.42	GO:0005576	extracellular region
0.36	GO:0046658	anchored component of plasma membrane
0.35	GO:0019897	extrinsic component of plasma membrane
0.32	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.69	EC:3.4.21	GO:0004252
0.32	KEGG:R03657	GO:0004823

tr|T1EEZ2|T1EEZ2_HELRO
Uncharacterized protein
Search

0.10	Molting fluid carboxypeptidase A

0.61	GO:0006508	proteolysis
0.37	GO:0042730	fibrinolysis
0.37	GO:0071555	cell wall organization
0.34	GO:0002002	regulation of angiotensin levels in blood
0.34	GO:0005975	carbohydrate metabolic process

0.78	GO:0004181	metallocarboxypeptidase activity
0.63	GO:0008270	zinc ion binding
0.34	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.33	GO:0004222	metalloendopeptidase activity

0.40	GO:0005615	extracellular space
0.38	GO:0005773	vacuole
0.33	GO:0031012	extracellular matrix
0.30	GO:0016020	membrane

0.78

GO:0004181

tr|T1EEZ3|T1EEZ3_HELRO
Uncharacterized protein
Search

SLC25A21

0.90	Mitochondrial oxodicarboxylate carrier

0.46	GO:0055085	transmembrane transport
0.44	GO:0006839	mitochondrial transport
0.44	GO:0006835	dicarboxylic acid transport
0.34	GO:0006554	lysine catabolic process
0.33	GO:0051181	cofactor transport

0.45	GO:0005310	dicarboxylic acid transmembrane transporter activity
0.34	GO:0051184	cofactor transmembrane transporter activity

0.40	GO:0005743	mitochondrial inner membrane
0.30	GO:0016021	integral component of membrane

tr|T1EEZ4|T1EEZ4_HELRO
Uncharacterized protein
Search

0.44	Zinc finger protein 697 (Fragment)

0.46	GO:1903506	regulation of nucleic acid-templated transcription
0.46	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.45	GO:0010468	regulation of gene expression
0.34	GO:0006351	transcription, DNA-templated
0.34	GO:0030706	germarium-derived oocyte differentiation
0.33	GO:1902679	negative regulation of RNA biosynthetic process
0.32	GO:0032259	methylation
0.32	GO:0006413	translational initiation

0.51	GO:0003676	nucleic acid binding
0.44	GO:0046872	metal ion binding
0.38	GO:0003700	DNA binding transcription factor activity
0.32	GO:0008168	methyltransferase activity

0.39	GO:0005622	intracellular
0.35	GO:0043227	membrane-bounded organelle
0.32	GO:0043234	protein complex
0.32	GO:0044422	organelle part
0.30	GO:0016020	membrane

0.32

GO:0008168

tr|T1EEZ5|T1EEZ5_HELRO
Uncharacterized protein
Search

0.10	Muscarinic acetylcholine receptor M1

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.64	GO:0095500	acetylcholine receptor signaling pathway
0.39	GO:0046541	saliva secretion
0.38	GO:0007271	synaptic transmission, cholinergic
0.38	GO:0050890	cognition
0.37	GO:0007210	serotonin receptor signaling pathway
0.37	GO:0040012	regulation of locomotion

0.72	GO:0004930	G-protein coupled receptor activity
0.64	GO:0015464	acetylcholine receptor activity
0.37	GO:0099589	serotonin receptor activity

0.53

GO:0005887

integral component of plasma membrane

tr|T1EEZ6|T1EEZ6_HELRO
Uncharacterized protein
Search

ADAL

0.43	Adenosine deaminase like

0.46	GO:0006154	adenosine catabolic process
0.46	GO:0046103	inosine biosynthetic process
0.44	GO:0043103	hypoxanthine salvage
0.34	GO:0009117	nucleotide metabolic process
0.33	GO:0046907	intracellular transport
0.32	GO:0007165	signal transduction

0.73	GO:0019239	deaminase activity
0.42	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
0.34	GO:0046872	metal ion binding
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0032561	guanyl ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.40	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.42

EC:3.5.4

GO:0016814

tr|T1EEZ7|T1EEZ7_HELRO
Uncharacterized protein
Search

0.26	Protein tyrosine kinase

0.75	GO:0018108	peptidyl-tyrosine phosphorylation
0.56	GO:0007166	cell surface receptor signaling pathway
0.54	GO:0090175	regulation of establishment of planar polarity
0.53	GO:0060026	convergent extension
0.53	GO:0001736	establishment of planar polarity
0.50	GO:0198738	cell-cell signaling by wnt
0.48	GO:0035556	intracellular signal transduction
0.44	GO:0046777	protein autophosphorylation
0.44	GO:0010543	regulation of platelet activation
0.41	GO:0042060	wound healing

0.75	GO:0004713	protein tyrosine kinase activity
0.56	GO:0019199	transmembrane receptor protein kinase activity
0.55	GO:1904929	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.38	GO:0005515	protein binding
0.35	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding

0.52	GO:0005887	integral component of plasma membrane
0.39	GO:0005622	intracellular
0.38	GO:0005911	cell-cell junction
0.37	GO:0098857	membrane microdomain
0.37	GO:0019897	extrinsic component of plasma membrane
0.37	GO:0009898	cytoplasmic side of plasma membrane
0.36	GO:0043226	organelle
0.35	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.33	GO:0031975	envelope

0.75

GO:0004713

tr|T1EEZ8|T1EEZ8_HELRO
Uncharacterized protein
Search

DCAF8

0.88	WD repeat-containing protein 42A

0.52	GO:0016567	protein ubiquitination
0.43	GO:0043687	post-translational protein modification

0.39

GO:0005515

protein binding

0.63	GO:0042579	microbody
0.58	GO:0080008	Cul4-RING E3 ubiquitin ligase complex
0.51	GO:0005634	nucleus
0.47	GO:0005829	cytosol
0.47	GO:0031974	membrane-enclosed lumen
0.44	GO:0005739	mitochondrion
0.42	GO:0044446	intracellular organelle part
0.38	GO:1990904	ribonucleoprotein complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1EEZ9|T1EEZ9_HELRO
Galactoside 2-alpha-L-fucosyltransferase
Search

0.40	Galactoside 2-alpha-L-fucosyltransferase

0.81	GO:0036065	fucosylation
0.74	GO:0006486	protein glycosylation
0.60	GO:0005975	carbohydrate metabolic process

0.84

GO:0008107

galactoside 2-alpha-L-fucosyltransferase activity

0.81	GO:0032580	Golgi cisterna membrane
0.30	GO:0016021	integral component of membrane

0.84

EC:2.4.1.69

GO:0008107

tr|T1EF00|T1EF00_HELRO
Uncharacterized protein
Search

0.10	Collagen alpha-1(IV) chain preproprotein (Fragment)

0.44	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
0.43	GO:0061304	retinal blood vessel morphogenesis
0.43	GO:0030198	extracellular matrix organization
0.43	GO:0072001	renal system development
0.42	GO:0007155	cell adhesion
0.42	GO:0007528	neuromuscular junction development
0.42	GO:0001569	branching involved in blood vessel morphogenesis
0.42	GO:0071230	cellular response to amino acid stimulus
0.40	GO:0007420	brain development
0.37	GO:0030903	notochord development

0.58	GO:0005201	extracellular matrix structural constituent
0.42	GO:0048407	platelet-derived growth factor binding
0.36	GO:0005178	integrin binding
0.34	GO:0097493	structural molecule activity conferring elasticity
0.34	GO:0042302	structural constituent of cuticle
0.32	GO:0046872	metal ion binding

0.69	GO:0005581	collagen trimer
0.52	GO:0031012	extracellular matrix
0.41	GO:0099081	supramolecular polymer
0.40	GO:0005615	extracellular space
0.35	GO:0005788	endoplasmic reticulum lumen
0.32	GO:0019012	virion
0.30	GO:0016020	membrane

tr|T1EF01|T1EF01_HELRO
60S ribosomal protein L18a
Search

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.37	GO:0097327	response to antineoplastic agent
0.34	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.33	GO:0019083	viral transcription
0.33	GO:0016072	rRNA metabolic process
0.33	GO:0042254	ribosome biogenesis

0.64	GO:0003735	structural constituent of ribosome
0.40	GO:0003723	RNA binding
0.34	GO:0003870	5-aminolevulinate synthase activity
0.34	GO:0005515	protein binding
0.33	GO:0030170	pyridoxal phosphate binding

0.61	GO:0005840	ribosome
0.48	GO:0005844	polysome
0.48	GO:0044445	cytosolic part
0.42	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.34	EC:2.3.1.37	GO:0003870
0.34	KEGG:R00830	GO:0003870

tr|T1EF02|T1EF02_HELRO
Uncharacterized protein
Search

0.81	Long-chain fatty acyl-CoA synthetase 4

0.46	GO:0001676	long-chain fatty acid metabolic process
0.45	GO:0032501	multicellular organismal process
0.44	GO:1900744	regulation of p38MAPK cascade
0.44	GO:0030510	regulation of BMP signaling pathway
0.44	GO:2001247	positive regulation of phosphatidylcholine biosynthetic process
0.44	GO:0044539	long-chain fatty acid import
0.44	GO:0042998	positive regulation of Golgi to plasma membrane protein transport
0.43	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
0.43	GO:0051896	regulation of protein kinase B signaling
0.43	GO:0065005	protein-lipid complex assembly

0.52	GO:0016874	ligase activity
0.41	GO:0019901	protein kinase binding
0.41	GO:0019904	protein domain specific binding
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0008144	drug binding

0.45	GO:0005811	lipid droplet
0.41	GO:0048471	perinuclear region of cytoplasm
0.41	GO:0005783	endoplasmic reticulum
0.40	GO:0044233	ER-mitochondrion membrane contact site
0.40	GO:0005794	Golgi apparatus
0.37	GO:0005777	peroxisome
0.37	GO:0005739	mitochondrion
0.36	GO:0031903	microbody membrane
0.35	GO:0030424	axon
0.35	GO:0031968	organelle outer membrane

0.52

GO:0016874

tr|T1EF03|T1EF03_HELRO
Uncharacterized protein
Search

ECI2

0.84	Enoyl-CoA delta isomerase 2, mitochondrial

0.36	GO:0006635	fatty acid beta-oxidation
0.35	GO:0019915	lipid storage
0.35	GO:0016573	histone acetylation
0.33	GO:0006836	neurotransmitter transport
0.32	GO:0006574	valine catabolic process
0.32	GO:0055085	transmembrane transport

0.77	GO:0000062	fatty-acyl-CoA binding
0.52	GO:0016853	isomerase activity
0.43	GO:0005102	receptor binding
0.35	GO:0004402	histone acetyltransferase activity
0.34	GO:0004300	enoyl-CoA hydratase activity
0.33	GO:0005328	neurotransmitter:sodium symporter activity
0.32	GO:0003860	3-hydroxyisobutyryl-CoA hydrolase activity

0.45	GO:0005777	peroxisome
0.43	GO:0005654	nucleoplasm
0.40	GO:0005739	mitochondrion
0.34	GO:0031907	microbody lumen
0.30	GO:0031224	intrinsic component of membrane

0.52

GO:0016853

tr|T1EF04|T1EF04_HELRO
Uncharacterized protein
Search

L3HYPDH

0.56	trans-3-hydroxy-L-proline dehydratase

0.77	GO:0018112	proline racemase activity
0.72	GO:0050346	trans-L-3-hydroxyproline dehydratase activity

0.77	EC:5.1.1.4	GO:0018112
0.77	KEGG:R01255	GO:0018112

tr|T1EF05|T1EF05_HELRO
Malic enzyme
Search

ME1

0.52	NADP-dependent malic enzyme

0.52	GO:0055114	oxidation-reduction process
0.48	GO:1902031	regulation of NADP metabolic process
0.46	GO:0006108	malate metabolic process
0.45	GO:0051262	protein tetramerization
0.39	GO:0006090	pyruvate metabolic process
0.35	GO:0009725	response to hormone
0.34	GO:0009743	response to carbohydrate
0.34	GO:0019216	regulation of lipid metabolic process
0.34	GO:0006741	NADP biosynthetic process
0.33	GO:0005975	carbohydrate metabolic process

0.78	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity
0.67	GO:0051287	NAD binding
0.54	GO:0046872	metal ion binding
0.48	GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity
0.36	GO:0008948	oxaloacetate decarboxylase activity
0.34	GO:0043531	ADP binding
0.33	GO:0050661	NADP binding
0.33	GO:0005515	protein binding
0.33	GO:0009055	electron transfer activity

0.41	GO:0005739	mitochondrion
0.34	GO:0005829	cytosol
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.78	EC:1.1.1.38 EC:1.1.1.39	GO:0004471
0.78	KEGG:R00214	GO:0004471

tr|T1EF06|T1EF06_HELRO
Uncharacterized protein
Search

0.35	Peripheral plasma membrane protein CASK

0.61	GO:0006468	protein phosphorylation
0.43	GO:0097112	gamma-aminobutyric acid receptor clustering
0.43	GO:1903361	protein localization to basolateral plasma membrane
0.43	GO:0040026	positive regulation of vulval development
0.42	GO:0019098	reproductive behavior
0.42	GO:0018212	peptidyl-tyrosine modification
0.40	GO:0009791	post-embryonic development
0.37	GO:1900244	positive regulation of synaptic vesicle endocytosis
0.37	GO:0016080	synaptic vesicle targeting
0.36	GO:0007615	anesthesia-resistant memory

0.62	GO:0004672	protein kinase activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0005159	insulin-like growth factor receptor binding
0.37	GO:0005516	calmodulin binding
0.36	GO:0042043	neurexin family protein binding
0.35	GO:0004385	guanylate kinase activity
0.34	GO:0004842	ubiquitin-protein transferase activity
0.32	GO:0016746	transferase activity, transferring acyl groups

0.39	GO:0030054	cell junction
0.36	GO:0061174	type I terminal bouton
0.36	GO:0005886	plasma membrane
0.36	GO:0031594	neuromuscular junction
0.30	GO:0016021	integral component of membrane

0.35	EC:2.7.4.8	GO:0004385
0.34	KEGG:R03876	GO:0004842

tr|T1EF07|T1EF07_HELRO
Uncharacterized protein
Search

TRIM2

0.79	tripartite motif-containing protein 2

0.43	GO:0060215	primitive hemopoiesis
0.41	GO:0030099	myeloid cell differentiation
0.41	GO:0016567	protein ubiquitination
0.34	GO:0043523	regulation of neuron apoptotic process
0.34	GO:0030514	negative regulation of BMP signaling pathway
0.34	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
0.32	GO:0015031	protein transport

0.61	GO:0008270	zinc ion binding
0.41	GO:0004842	ubiquitin-protein transferase activity
0.36	GO:0061659	ubiquitin-like protein ligase activity
0.34	GO:0070410	co-SMAD binding
0.34	GO:0070412	R-SMAD binding
0.34	GO:0016874	ligase activity

0.44	GO:0005622	intracellular
0.33	GO:0030425	dendrite
0.33	GO:0031982	vesicle
0.32	GO:0012505	endomembrane system

0.34	EC:6	GO:0016874
0.41	KEGG:R03876	GO:0004842

tr|T1EF08|T1EF08_HELRO
Uncharacterized protein
Search

EDF1

0.91	LOW QUALITY PROTEIN: endothelial differentiation-related factor 1 homolog

0.55	GO:0043388	positive regulation of DNA binding
0.42	GO:1903506	regulation of nucleic acid-templated transcription
0.37	GO:0030154	cell differentiation
0.37	GO:0007275	multicellular organism development
0.37	GO:0006351	transcription, DNA-templated
0.36	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.36	GO:0010468	regulation of gene expression
0.35	GO:0003158	endothelium development
0.35	GO:0019216	regulation of lipid metabolic process
0.34	GO:1902680	positive regulation of RNA biosynthetic process

0.64	GO:0043565	sequence-specific DNA binding
0.52	GO:0003713	transcription coactivator activity
0.39	GO:0005516	calmodulin binding
0.36	GO:0004402	histone acetyltransferase activity
0.34	GO:0008168	methyltransferase activity
0.34	GO:0003700	DNA binding transcription factor activity
0.34	GO:0003723	RNA binding

0.52	GO:0005669	transcription factor TFIID complex
0.49	GO:0005730	nucleolus
0.47	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome

0.36

GO:0004402

tr|T1EF09|T1EF09_HELRO
Uncharacterized protein
Search

UNC45B

0.87	Translocase of outer membrane 34

0.73	GO:0061077	chaperone-mediated protein folding
0.62	GO:0061061	muscle structure development
0.62	GO:0031034	myosin filament assembly
0.57	GO:0034605	cellular response to heat
0.51	GO:0002088	lens development in camera-type eye
0.48	GO:0072359	circulatory system development
0.47	GO:0009888	tissue development
0.46	GO:0048646	anatomical structure formation involved in morphogenesis
0.46	GO:0031032	actomyosin structure organization
0.45	GO:0030154	cell differentiation

0.71	GO:0051879	Hsp90 protein binding
0.46	GO:0045296	cadherin binding
0.40	GO:0043130	ubiquitin binding
0.38	GO:0004842	ubiquitin-protein transferase activity
0.36	GO:0008270	zinc ion binding
0.36	GO:0016874	ligase activity
0.36	GO:0003723	RNA binding

0.59	GO:0005829	cytosol
0.46	GO:0030018	Z disc
0.46	GO:0016607	nuclear speck
0.43	GO:0005794	Golgi apparatus
0.39	GO:0031672	A band
0.38	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.36	EC:6	GO:0016874
0.38	KEGG:R03876	GO:0004842

tr|T1EF10|T1EF10_HELRO
Uncharacterized protein
Search

RETSAT

0.67	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

0.61	GO:0042572	retinol metabolic process
0.47	GO:0055114	oxidation-reduction process
0.43	GO:0007264	small GTPase mediated signal transduction
0.41	GO:0050790	regulation of catalytic activity

0.65	GO:0051786	all-trans-retinol 13,14-reductase activity
0.45	GO:0005092	GDP-dissociation inhibitor activity
0.35	GO:0050660	flavin adenine dinucleotide binding
0.35	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
0.33	GO:0005201	extracellular matrix structural constituent

0.59	GO:0005640	nuclear outer membrane
0.52	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.65	EC:1.3.99.23	GO:0051786
0.65	KEGG:R07163	GO:0051786

tr|T1EF11|T1EF11_HELRO
Uncharacterized protein
Search

tr|T1EF12|T1EF12_HELRO
Uncharacterized protein
Search

0.43	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
0.42	GO:0007528	neuromuscular junction development
0.41	GO:0048731	system development
0.40	GO:0030198	extracellular matrix organization
0.40	GO:0035124	embryonic caudal fin morphogenesis
0.39	GO:0031101	fin regeneration
0.38	GO:0010466	negative regulation of peptidase activity
0.37	GO:0052548	regulation of endopeptidase activity
0.36	GO:0030574	collagen catabolic process
0.35	GO:0001894	tissue homeostasis

0.67	GO:0005201	extracellular matrix structural constituent
0.38	GO:0030414	peptidase inhibitor activity
0.38	GO:0061135	endopeptidase regulator activity
0.37	GO:0042302	structural constituent of cuticle
0.37	GO:0005509	calcium ion binding
0.34	GO:0008201	heparin binding
0.33	GO:0030246	carbohydrate binding
0.33	GO:0005515	protein binding
0.32	GO:0016875	ligase activity, forming carbon-oxygen bonds
0.32	GO:0005044	scavenger receptor activity

0.68	GO:0005581	collagen trimer
0.64	GO:0005604	basement membrane
0.47	GO:0098645	collagen network
0.42	GO:0031594	neuromuscular junction
0.37	GO:0005938	cell cortex
0.35	GO:0005829	cytosol
0.35	GO:0005788	endoplasmic reticulum lumen
0.33	GO:0005911	cell-cell junction
0.33	GO:0019867	outer membrane
0.33	GO:0031514	motile cilium

0.32

EC:6.1

GO:0016875

tr|T1EF13|T1EF13_HELRO
RNA cytidine acetyltransferase
Search

NAT10

0.71	RNA cytidine acetyltransferase

0.80	GO:1990884	RNA acetylation
0.71	GO:0042274	ribosomal small subunit biogenesis
0.68	GO:0000154	rRNA modification
0.65	GO:0006400	tRNA modification
0.47	GO:0032211	negative regulation of telomere maintenance via telomerase

0.68	GO:0008080	N-acetyltransferase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0070182	DNA polymerase binding
0.41	GO:0000049	tRNA binding

0.70	GO:0005730	nucleolus
0.47	GO:0005697	telomerase holoenzyme complex
0.44	GO:0030496	midbody
0.44	GO:0030686	90S preribosome
0.37	GO:0000784	nuclear chromosome, telomeric region
0.35	GO:0030688	preribosome, small subunit precursor
0.30	GO:0031224	intrinsic component of membrane

0.68

EC:2.3.1

GO:0008080

tr|T1EF14|T1EF14_HELRO
Uncharacterized protein
Search

TSSK1B

0.91	LOW QUALITY PROTEIN: testis-specific serine/threonine-protein kinase 1

0.63	GO:0006468	protein phosphorylation
0.47	GO:0007286	spermatid development
0.44	GO:0035556	intracellular signal transduction
0.37	GO:0043066	negative regulation of apoptotic process
0.35	GO:0007275	multicellular organism development
0.33	GO:0030010	establishment of cell polarity
0.33	GO:0005978	glycogen biosynthetic process
0.33	GO:0000226	microtubule cytoskeleton organization

0.67	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0000287	magnesium ion binding
0.34	GO:0005515	protein binding
0.32	GO:0016787	hydrolase activity

0.44	GO:0031514	motile cilium
0.43	GO:0005634	nucleus
0.40	GO:0001669	acrosomal vesicle
0.37	GO:0005814	centriole
0.34	GO:0005964	phosphorylase kinase complex
0.30	GO:0016020	membrane

0.67

GO:0004674

tr|T1EF15|T1EF15_HELRO
Uncharacterized protein
Search

tr|T1EF16|T1EF16_HELRO
Uncharacterized protein
Search

0.80	GO:0072662	protein localization to peroxisome
0.80	GO:0043574	peroxisomal transport
0.72	GO:0072594	establishment of protein localization to organelle
0.70	GO:0006605	protein targeting
0.53	GO:0060152	microtubule-based peroxisome localization
0.47	GO:0017038	protein import
0.46	GO:0065002	intracellular protein transmembrane transport
0.42	GO:0048137	spermatocyte division
0.40	GO:0021782	glial cell development
0.40	GO:0007422	peripheral nervous system development

0.63	GO:0042623	ATPase activity, coupled
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0008022	protein C-terminus binding
0.46	GO:0032403	protein complex binding
0.35	GO:0046982	protein heterodimerization activity
0.34	GO:0019842	vitamin binding
0.33	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.33	GO:0008289	lipid binding

0.78	GO:0031903	microbody membrane
0.78	GO:0044439	peroxisomal part
0.44	GO:0005829	cytosol
0.35	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0004714

tr|T1EF17|T1EF17_HELRO
Uncharacterized protein
Search

ARHGAP42

0.70	Rho GTPase-activating protein 26

0.75	GO:0043547	positive regulation of GTPase activity
0.61	GO:0007165	signal transduction
0.49	GO:1904694	negative regulation of vascular smooth muscle contraction
0.48	GO:0003085	negative regulation of systemic arterial blood pressure
0.48	GO:0035024	negative regulation of Rho protein signal transduction
0.38	GO:0030036	actin cytoskeleton organization
0.34	GO:0007399	nervous system development

0.75	GO:0005096	GTPase activator activity
0.36	GO:0005543	phospholipid binding
0.33	GO:0005515	protein binding

0.34	GO:0005925	focal adhesion
0.33	GO:0005856	cytoskeleton
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

tr|T1EF18|T1EF18_HELRO
Uncharacterized protein
Search

DAW1

0.96	Dynein assembly factor with WDR repeat domains 1

0.75	GO:0007368	determination of left/right symmetry
0.71	GO:0007507	heart development
0.39	GO:0048870	cell motility
0.39	GO:0070286	axonemal dynein complex assembly
0.37	GO:0006955	immune response
0.37	GO:0006935	chemotaxis
0.37	GO:0010469	regulation of receptor activity
0.36	GO:0070887	cellular response to chemical stimulus
0.33	GO:0016573	histone acetylation

0.39	GO:0008009	chemokine activity
0.36	GO:0005509	calcium ion binding
0.33	GO:0004402	histone acetyltransferase activity

0.50	GO:0005929	cilium
0.43	GO:0005737	cytoplasm
0.36	GO:0005576	extracellular region
0.36	GO:0005856	cytoskeleton
0.30	GO:0016020	membrane

0.33

GO:0004402

tr|T1EF19|T1EF19_HELRO
Uncharacterized protein
Search

NDE1

0.64	Nuclear distribution protein nudE

0.85	GO:2000574	regulation of microtubule motor activity
0.82	GO:0007100	mitotic centrosome separation
0.81	GO:0060052	neurofilament cytoskeleton organization
0.69	GO:0007399	nervous system development
0.55	GO:0047496	vesicle transport along microtubule
0.54	GO:0051642	centrosome localization
0.54	GO:1900029	positive regulation of ruffle assembly
0.52	GO:0032418	lysosome localization
0.51	GO:0016477	cell migration
0.51	GO:0008090	retrograde axonal transport

0.50	GO:0043014	alpha-tubulin binding
0.50	GO:0008017	microtubule binding
0.49	GO:0048487	beta-tubulin binding
0.48	GO:0042802	identical protein binding
0.38	GO:0070012	oligopeptidase activity
0.36	GO:0032403	protein complex binding
0.34	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.53	GO:0060053	neurofilament cytoskeleton
0.53	GO:0000776	kinetochore
0.52	GO:0005813	centrosome
0.52	GO:0043203	axon hillock
0.50	GO:1904115	axon cytoplasm
0.50	GO:0005875	microtubule associated complex
0.48	GO:0008021	synaptic vesicle
0.48	GO:0031252	cell leading edge
0.45	GO:0005819	spindle
0.41	GO:0005874	microtubule

0.34

GO:0004714

tr|T1EF20|T1EF20_HELRO
Uncharacterized protein
Search

RAB5A

0.75	Ras-related protein Rab-17 (inferred by orthology to a human protein)

0.54	GO:0060627	regulation of vesicle-mediated transport
0.51	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway
0.51	GO:0051489	regulation of filopodium assembly
0.50	GO:0051036	regulation of endosome size
0.50	GO:0045056	transcytosis
0.49	GO:0045022	early endosome to late endosome transport
0.49	GO:0098693	regulation of synaptic vesicle cycle
0.49	GO:0046928	regulation of neurotransmitter secretion
0.49	GO:0036465	synaptic vesicle recycling
0.47	GO:0032386	regulation of intracellular transport

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.54	GO:0019003	GDP binding
0.43	GO:0030742	GTP-dependent protein binding
0.36	GO:0032794	GTPase activating protein binding
0.35	GO:0051021	GDP-dissociation inhibitor binding
0.34	GO:0004767	sphingomyelin phosphodiesterase activity
0.33	GO:0004402	histone acetyltransferase activity

0.54	GO:0030139	endocytic vesicle
0.54	GO:0005769	early endosome
0.50	GO:0010009	cytoplasmic side of endosome membrane
0.49	GO:0043195	terminal bouton
0.48	GO:0001726	ruffle
0.46	GO:0036477	somatodendritic compartment
0.46	GO:0098857	membrane microdomain
0.44	GO:0015629	actin cytoskeleton
0.44	GO:0005829	cytosol
0.43	GO:0070062	extracellular exosome

0.34	EC:3.1.4.12	GO:0004767
0.34	KEGG:R02541	GO:0004767

tr|T1EF21|T1EF21_HELRO
Uncharacterized protein
Search

0.37	Frayed (inferred by orthology to a D. melanogaster protein)

0.65	GO:0023014	signal transduction by protein phosphorylation
0.61	GO:0035556	intracellular signal transduction
0.46	GO:0008065	establishment of blood-nerve barrier
0.46	GO:0008362	chitin-based embryonic cuticle biosynthetic process
0.45	GO:0072697	protein localization to cell cortex
0.44	GO:0008366	axon ensheathment
0.44	GO:0035295	tube development
0.43	GO:0046777	protein autophosphorylation
0.41	GO:0048513	animal organ development
0.39	GO:0036251	positive regulation of transcription from RNA polymerase II promoter in response to salt stress

0.77	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0019901	protein kinase binding
0.34	GO:0004697	protein kinase C activity
0.32	GO:0016787	hydrolase activity

0.44	GO:0005622	intracellular
0.32	GO:0043227	membrane-bounded organelle
0.30	GO:0016020	membrane

0.77

GO:0004702

tr|T1EF22|T1EF22_HELRO
Uncharacterized protein
Search

0.10	Histone-lysine N-methyltransferase

0.78	GO:0034968	histone lysine methylation
0.42	GO:0051216	cartilage development
0.42	GO:0048706	embryonic skeletal system development
0.35	GO:0045892	negative regulation of transcription, DNA-templated
0.34	GO:0018992	germ-line sex determination
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:0016458	gene silencing
0.33	GO:0035556	intracellular signal transduction

0.79	GO:0018024	histone-lysine N-methyltransferase activity
0.53	GO:0046872	metal ion binding
0.38	GO:0031490	chromatin DNA binding
0.33	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.38	GO:0005721	pericentric heterochromatin
0.38	GO:0005700	polytene chromosome
0.34	GO:0031974	membrane-enclosed lumen
0.30	GO:0016020	membrane

0.79

GO:0018024

tr|T1EF23|T1EF23_HELRO
Serine/threonine-protein phosphatase
Search

PPP1CB

0.49	Serine/threonine-protein phosphatase

0.72	GO:0006470	protein dephosphorylation
0.51	GO:0042752	regulation of circadian rhythm
0.49	GO:0030155	regulation of cell adhesion
0.45	GO:0032922	circadian regulation of gene expression
0.45	GO:0009648	photoperiodism
0.41	GO:0005977	glycogen metabolic process
0.41	GO:0060028	convergent extension involved in axis elongation
0.40	GO:0009605	response to external stimulus
0.40	GO:0051301	cell division
0.40	GO:0007049	cell cycle

0.77	GO:0004722	protein serine/threonine phosphatase activity
0.57	GO:0050115	myosin-light-chain-phosphatase activity
0.53	GO:0046872	metal ion binding
0.48	GO:0019901	protein kinase binding
0.38	GO:0046982	protein heterodimerization activity

0.84	GO:0000164	protein phosphatase type 1 complex
0.81	GO:0072357	PTW/PP1 phosphatase complex
0.49	GO:0000784	nuclear chromosome, telomeric region
0.44	GO:0005829	cytosol
0.39	GO:0005886	plasma membrane
0.39	GO:0005730	nucleolus
0.39	GO:0005654	nucleoplasm
0.37	GO:0042587	glycogen granule
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome

0.57

EC:3.1.3.53

GO:0050115

tr|T1EF24|T1EF24_HELRO
Uncharacterized protein
Search

XDH

0.51	Molybdopterin-binding domain of aldehyde dehydrogenase

0.59	GO:0022900	electron transport chain
0.56	GO:0009115	xanthine catabolic process
0.54	GO:2001213	negative regulation of vasculogenesis
0.53	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway
0.52	GO:0045602	negative regulation of endothelial cell differentiation
0.52	GO:1900745	positive regulation of p38MAPK cascade
0.51	GO:0001937	negative regulation of endothelial cell proliferation
0.51	GO:0051898	negative regulation of protein kinase B signaling
0.50	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
0.50	GO:2000379	positive regulation of reactive oxygen species metabolic process

0.79	GO:0004855	xanthine oxidase activity
0.78	GO:0004854	xanthine dehydrogenase activity
0.70	GO:0051537	2 iron, 2 sulfur cluster binding
0.69	GO:0043546	molybdopterin cofactor binding
0.66	GO:0050660	flavin adenine dinucleotide binding
0.65	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
0.62	GO:0005506	iron ion binding
0.60	GO:0009055	electron transfer activity
0.50	GO:0030151	molybdenum ion binding
0.47	GO:0042803	protein homodimerization activity

0.49	GO:0016529	sarcoplasmic reticulum
0.41	GO:0005829	cytosol
0.39	GO:0005615	extracellular space
0.39	GO:0005777	peroxisome
0.30	GO:0016020	membrane

0.79

EC:1.17.3.2

GO:0004855

tr|T1EF25|T1EF25_HELRO
Uncharacterized protein
Search

0.48	Tyrosine-protein kinase Fyn

0.73	GO:0018108	peptidyl-tyrosine phosphorylation
0.64	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.57	GO:2001028	positive regulation of endothelial cell chemotaxis
0.55	GO:0050918	positive chemotaxis
0.54	GO:0071526	semaphorin-plexin signaling pathway
0.50	GO:0070495	negative regulation of thrombin-activated receptor signaling pathway
0.50	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity
0.49	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
0.49	GO:0001886	endothelial cell morphogenesis
0.49	GO:0051497	negative regulation of stress fiber assembly

0.73	GO:0004713	protein tyrosine kinase activity
0.66	GO:0019199	transmembrane receptor protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0019903	protein phosphatase binding
0.44	GO:0042802	identical protein binding
0.41	GO:0004706	JUN kinase kinase kinase activity
0.40	GO:0005154	epidermal growth factor receptor binding

0.48	GO:0009925	basal plasma membrane
0.38	GO:0005856	cytoskeleton
0.38	GO:0005887	integral component of plasma membrane
0.35	GO:0009986	cell surface
0.35	GO:0098794	postsynapse
0.34	GO:0005773	vacuole
0.34	GO:0060076	excitatory synapse
0.34	GO:0120025	plasma membrane bounded cell projection
0.34	GO:0032279	asymmetric synapse
0.34	GO:0097223	sperm part

0.73	EC:2.7.10	GO:0004713
0.34	KEGG:R04545	GO:0046934

tr|T1EF26|T1EF26_HELRO
Uncharacterized protein
Search

DNAJB12

0.85	DnaJ like protein subfamily B member 12

0.42	GO:0051085	chaperone cofactor-dependent protein refolding
0.39	GO:0043623	cellular protein complex assembly
0.38	GO:0071218	cellular response to misfolded protein
0.38	GO:0036503	ERAD pathway
0.33	GO:0032259	methylation

0.41	GO:0030544	Hsp70 protein binding
0.33	GO:0008168	methyltransferase activity
0.33	GO:0046982	protein heterodimerization activity
0.33	GO:0003676	nucleic acid binding

0.39	GO:0005783	endoplasmic reticulum
0.37	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.37	GO:0031984	organelle subcompartment
0.36	GO:0031965	nuclear membrane
0.33	GO:0000786	nucleosome
0.30	GO:0016021	integral component of membrane

0.33

GO:0008168

tr|T1EF27|T1EF27_HELRO
Uncharacterized protein
Search

0.55	GO:0055085	transmembrane transport
0.45	GO:0009306	protein secretion
0.38	GO:0042908	xenobiotic transport
0.37	GO:0006820	anion transport
0.37	GO:0015893	drug transport
0.36	GO:0030218	erythrocyte differentiation
0.35	GO:0015886	heme transport
0.33	GO:0006629	lipid metabolic process
0.33	GO:0006508	proteolysis
0.32	GO:0055114	oxidation-reduction process

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0008565	protein transporter activity
0.39	GO:0042910	xenobiotic transmembrane transporter activity
0.38	GO:0008509	anion transmembrane transporter activity
0.37	GO:0015238	drug transmembrane transporter activity
0.35	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.34	GO:0005216	ion channel activity

0.49	GO:0030256	type I protein secretion system complex
0.36	GO:0005887	integral component of plasma membrane

0.35

GO:0032440

tr|T1EF28|T1EF28_HELRO
Malic enzyme
Search

0.57	NAD-dependent malic enzyme, mitochondrial

0.52	GO:0055114	oxidation-reduction process
0.42	GO:1902031	regulation of NADP metabolic process
0.41	GO:0042593	glucose homeostasis
0.40	GO:0006108	malate metabolic process
0.38	GO:0006090	pyruvate metabolic process

0.76	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity
0.66	GO:0051287	NAD binding
0.52	GO:0046872	metal ion binding
0.41	GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity
0.37	GO:0008948	oxaloacetate decarboxylase activity

0.37	GO:0005739	mitochondrion
0.33	GO:0070013	intracellular organelle lumen
0.32	GO:0044446	intracellular organelle part

0.76	EC:1.1.1.38 EC:1.1.1.39	GO:0004471
0.76	KEGG:R00214	GO:0004471

tr|T1EF29|T1EF29_HELRO
Uncharacterized protein
Search

0.56	GO:1904998	negative regulation of leukocyte adhesion to arterial endothelial cell
0.56	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production
0.55	GO:0046985	positive regulation of hemoglobin biosynthetic process
0.55	GO:0045415	negative regulation of interleukin-8 biosynthetic process
0.54	GO:0071499	cellular response to laminar fluid shear stress
0.54	GO:0061614	pri-miRNA transcription by RNA polymerase II
0.54	GO:0034115	negative regulation of heterotypic cell-cell adhesion
0.53	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
0.53	GO:0035166	post-embryonic hemopoiesis
0.53	GO:0031077	post-embryonic camera-type eye development

0.52	GO:1990841	promoter-specific chromatin binding
0.52	GO:0001010	transcription factor activity, sequence-specific DNA binding transcription factor recruiting
0.52	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.51	GO:0003676	nucleic acid binding
0.51	GO:0001085	RNA polymerase II transcription factor binding
0.50	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.49	GO:0008013	beta-catenin binding
0.38	GO:0001221	transcription cofactor binding
0.38	GO:0035014	phosphatidylinositol 3-kinase regulator activity
0.38	GO:0042826	histone deacetylase binding

0.50	GO:0005719	nuclear euchromatin
0.47	GO:0044798	nuclear transcription factor complex
0.46	GO:0005654	nucleoplasm
0.37	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EF30|T1EF30_HELRO
Uncharacterized protein
Search

MTIF2

0.43	Translation initiation factor if-mitochondrial

0.68	GO:0006413	translational initiation
0.39	GO:0032790	ribosome disassembly
0.39	GO:0032543	mitochondrial translation
0.34	GO:0006414	translational elongation
0.34	GO:0006446	regulation of translational initiation
0.34	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.34	GO:0018108	peptidyl-tyrosine phosphorylation
0.32	GO:0006508	proteolysis

0.69	GO:0003743	translation initiation factor activity
0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0043024	ribosomal small subunit binding
0.34	GO:0003746	translation elongation factor activity
0.34	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.33	GO:0000049	tRNA binding

0.45	GO:0005654	nucleoplasm
0.42	GO:0005739	mitochondrion
0.32	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0004714

tr|T1EF31|T1EF31_HELRO
Uncharacterized protein
Search

0.61	GO:0006508	proteolysis
0.48	GO:0006898	receptor-mediated endocytosis
0.44	GO:0007596	blood coagulation
0.44	GO:0006883	cellular sodium ion homeostasis
0.42	GO:0007605	sensory perception of sound
0.40	GO:0006955	immune response
0.38	GO:0065009	regulation of molecular function
0.37	GO:0044537	regulation of circulating fibrinogen levels
0.37	GO:1901552	positive regulation of endothelial cell development
0.37	GO:0072376	protein activation cascade

0.69	GO:0004252	serine-type endopeptidase activity
0.51	GO:0005044	scavenger receptor activity
0.43	GO:0017080	sodium channel regulator activity
0.43	GO:0005509	calcium ion binding
0.39	GO:0030246	carbohydrate binding
0.39	GO:0001871	pattern binding
0.36	GO:0070012	oligopeptidase activity
0.35	GO:0043621	protein self-association
0.33	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.33	GO:0016301	kinase activity

0.42	GO:0043025	neuronal cell body
0.41	GO:0012505	endomembrane system
0.40	GO:0005576	extracellular region
0.39	GO:0097223	sperm part
0.39	GO:0031984	organelle subcompartment
0.39	GO:0099503	secretory vesicle
0.37	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0004252

tr|T1EF32|T1EF32_HELRO
Uncharacterized protein
Search

0.60	Endothelin-converting enzyme

0.71	GO:0016486	peptide hormone processing
0.40	GO:0007218	neuropeptide signaling pathway
0.37	GO:0048703	embryonic viscerocranium morphogenesis
0.34	GO:0016567	protein ubiquitination
0.33	GO:0006996	organelle organization

0.70	GO:0004222	metalloendopeptidase activity
0.34	GO:0004842	ubiquitin-protein transferase activity
0.32	GO:0046872	metal ion binding

0.34	GO:0030659	cytoplasmic vesicle membrane
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.70	EC:3.4.24	GO:0004222
0.34	KEGG:R03876	GO:0004842

tr|T1EF33|T1EF33_HELRO
Uncharacterized protein
Search

0.10	ATP-dependent RNA helicase DDX50

0.41	GO:0010501	RNA secondary structure unwinding
0.38	GO:1902626	assembly of large subunit precursor of preribosome
0.38	GO:0000470	maturation of LSU-rRNA
0.37	GO:0000027	ribosomal large subunit assembly
0.34	GO:1990417	snoRNA release from pre-rRNA
0.33	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

0.66	GO:0004386	helicase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0003676	nucleic acid binding
0.40	GO:0008186	RNA-dependent ATPase activity
0.37	GO:0140098	catalytic activity, acting on RNA
0.33	GO:0042802	identical protein binding

0.47	GO:0005634	nucleus
0.42	GO:0031974	membrane-enclosed lumen
0.39	GO:0043232	intracellular non-membrane-bounded organelle
0.39	GO:0044446	intracellular organelle part
0.38	GO:0030687	preribosome, large subunit precursor
0.37	GO:0030686	90S preribosome
0.36	GO:0005886	plasma membrane
0.34	GO:0005737	cytoplasm
0.34	GO:0072588	box H/ACA RNP complex
0.33	GO:0012505	endomembrane system

tr|T1EF34|T1EF34_HELRO
Uncharacterized protein
Search

NAP1L1

0.76	Nucleosome assembly

0.79	GO:0006334	nucleosome assembly
0.41	GO:0001878	response to yeast
0.38	GO:0002376	immune system process
0.37	GO:0071345	cellular response to cytokine stimulus
0.36	GO:0006952	defense response
0.36	GO:0048513	animal organ development
0.36	GO:0030154	cell differentiation

0.46	GO:0031491	nucleosome binding
0.33	GO:0051082	unfolded protein binding
0.32	GO:0003723	RNA binding

0.61	GO:0005634	nucleus
0.36	GO:0005737	cytoplasm

tr|T1EF35|T1EF35_HELRO
Uncharacterized protein
Search

0.48	GO:0001731	formation of translation preinitiation complex
0.47	GO:0006446	regulation of translational initiation
0.42	GO:0001522	pseudouridine synthesis
0.42	GO:0031047	gene silencing by RNA
0.39	GO:0008284	positive regulation of cell proliferation
0.39	GO:0006396	RNA processing
0.38	GO:0008213	protein alkylation
0.38	GO:0010628	positive regulation of gene expression
0.38	GO:0010044	response to aluminum ion
0.37	GO:0042254	ribosome biogenesis

0.54	GO:0003723	RNA binding
0.48	GO:0031369	translation initiation factor binding
0.40	GO:0009982	pseudouridine synthase activity
0.40	GO:0004386	helicase activity
0.38	GO:0008276	protein methyltransferase activity
0.37	GO:0042802	identical protein binding
0.37	GO:0032559	adenyl ribonucleotide binding
0.37	GO:0008144	drug binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0004534	5'-3' exoribonuclease activity

0.47	GO:0016282	eukaryotic 43S preinitiation complex
0.47	GO:0033290	eukaryotic 48S preinitiation complex
0.47	GO:0005852	eukaryotic translation initiation factor 3 complex
0.44	GO:0072669	tRNA-splicing ligase complex
0.40	GO:0031981	nuclear lumen
0.39	GO:0072588	box H/ACA RNP complex
0.36	GO:0043232	intracellular non-membrane-bounded organelle
0.35	GO:0005845	mRNA cap binding complex
0.35	GO:0019013	viral nucleocapsid
0.35	GO:1902494	catalytic complex

0.40

EC:5.4.99.12

GO:0009982

tr|T1EF36|T1EF36_HELRO
Uncharacterized protein
Search

0.67	Aryl hydrocarbon receptor nuclear translocator

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0006351	transcription, DNA-templated
0.56	GO:0010468	regulation of gene expression
0.45	GO:0045676	regulation of R7 cell differentiation
0.44	GO:0008347	glial cell migration
0.43	GO:0071456	cellular response to hypoxia
0.43	GO:0032869	cellular response to insulin stimulus
0.43	GO:0060173	limb development
0.42	GO:0048477	oogenesis

0.66	GO:0046983	protein dimerization activity
0.61	GO:0003700	DNA binding transcription factor activity
0.48	GO:0003677	DNA binding
0.43	GO:0017022	myosin binding
0.34	GO:0003989	acetyl-CoA carboxylase activity

0.75	GO:0005667	transcription factor complex
0.61	GO:0005634	nucleus
0.49	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.34

EC:6.4.1.2

GO:0003989

tr|T1EF37|T1EF37_HELRO
Uncharacterized protein
Search

PPOX

0.50	Protoporphyrinogen oxidase

0.73	GO:0006782	protoporphyrinogen IX biosynthetic process
0.52	GO:0055114	oxidation-reduction process
0.37	GO:0042493	response to drug

0.82	GO:0070818	protoporphyrinogen oxidase activity
0.76	GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
0.34	GO:0050660	flavin adenine dinucleotide binding

0.58	GO:0031966	mitochondrial membrane
0.58	GO:0019866	organelle inner membrane
0.49	GO:0031300	intrinsic component of organelle membrane
0.35	GO:0005758	mitochondrial intermembrane space
0.30	GO:0016021	integral component of membrane

0.76

EC:1.3.3

GO:0016634

tr|T1EF38|T1EF38_HELRO
Uncharacterized protein
Search

SUGCT

0.39	Succinate--hydroxymethylglutarate CoA-transferase

0.41	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.33	GO:1902222	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process
0.33	GO:0006570	tyrosine metabolic process
0.33	GO:0006558	L-phenylalanine metabolic process
0.33	GO:0009074	aromatic amino acid family catabolic process
0.33	GO:0008213	protein alkylation
0.33	GO:0042737	drug catabolic process
0.33	GO:0043414	macromolecule methylation
0.32	GO:0006351	transcription, DNA-templated
0.32	GO:0055114	oxidation-reduction process

0.77	GO:0033608	formyl-CoA transferase activity
0.42	GO:0004865	protein serine/threonine phosphatase inhibitor activity
0.41	GO:0047369	succinate-hydroxymethylglutarate CoA-transferase activity
0.34	GO:0033877	succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity
0.33	GO:0004411	homogentisate 1,2-dioxygenase activity
0.32	GO:0008168	methyltransferase activity
0.32	GO:0046872	metal ion binding
0.32	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
0.32	GO:0003723	RNA binding
0.32	GO:0003677	DNA binding

0.35	GO:0005739	mitochondrion
0.32	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.77	EC:2.8.3.16	GO:0033608
0.77	KEGG:R07290	GO:0033608

tr|T1EF39|T1EF39_HELRO
Uncharacterized protein
Search

FNTA

0.83	Farnesyltransferase/geranylgeranyltransferase type I alpha subunit

0.82	GO:0097354	prenylation
0.60	GO:0036211	protein modification process
0.56	GO:0044267	cellular protein metabolic process
0.41	GO:0090044	positive regulation of tubulin deacetylation
0.41	GO:0090045	positive regulation of deacetylase activity
0.40	GO:0045213	neurotransmitter receptor metabolic process
0.40	GO:0071340	skeletal muscle acetylcholine-gated channel clustering
0.39	GO:0099601	regulation of neurotransmitter receptor activity
0.35	GO:0022027	interkinetic nuclear migration
0.35	GO:0022400	regulation of rhodopsin mediated signaling pathway

0.83	GO:0008318	protein prenyltransferase activity
0.40	GO:0043014	alpha-tubulin binding
0.39	GO:0030548	acetylcholine receptor regulator activity
0.39	GO:0030971	receptor tyrosine kinase binding
0.38	GO:0008017	microtubule binding
0.34	GO:0042802	identical protein binding
0.34	GO:0008484	sulfuric ester hydrolase activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.47	GO:0005953	CAAX-protein geranylgeranyltransferase complex
0.46	GO:0005965	protein farnesyltransferase complex
0.38	GO:0005875	microtubule associated complex
0.35	GO:0070695	FHF complex
0.35	GO:0000242	pericentriolar material
0.35	GO:0034451	centriolar satellite
0.35	GO:0030897	HOPS complex
0.34	GO:0005829	cytosol
0.34	GO:0005801	cis-Golgi network
0.34	GO:0005886	plasma membrane

0.83

EC:2.5.1

GO:0008318

tr|T1EF40|T1EF40_HELRO
Uncharacterized protein
Search

0.81	Homeodomain transcription factor Post2

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.53	GO:0007275	multicellular organism development
0.46	GO:0060429	epithelium development
0.45	GO:1902680	positive regulation of RNA biosynthetic process
0.43	GO:0009653	anatomical structure morphogenesis
0.43	GO:0006366	transcription by RNA polymerase II
0.42	GO:0048857	neural nucleus development
0.40	GO:0060322	head development

0.63	GO:0043565	sequence-specific DNA binding
0.48	GO:0003700	DNA binding transcription factor activity
0.44	GO:0071837	HMG box domain binding
0.43	GO:0001047	core promoter binding
0.42	GO:0003682	chromatin binding
0.41	GO:0001012	RNA polymerase II regulatory region DNA binding
0.41	GO:0003690	double-stranded DNA binding
0.33	GO:0051721	protein phosphatase 2A binding

0.61	GO:0005634	nucleus
0.38	GO:0005829	cytosol
0.37	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

tr|T1EF41|T1EF41_HELRO
Uncharacterized protein
Search

FRA10AC1

0.96	Fragile site, folic acid type, rare, candidate 1

0.44	GO:0006481	C-terminal protein methylation
0.39	GO:0006508	proteolysis

0.45	GO:0004671	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
0.44	GO:0005515	protein binding
0.41	GO:0004252	serine-type endopeptidase activity

0.47	GO:0005634	nucleus
0.42	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

0.45	EC:2.1.1.100	GO:0004671
0.45	KEGG:R04496	GO:0004671

tr|T1EF42|T1EF42_HELRO
Phospholipid-transporting ATPase
Search

ATP8A1

0.58	Phospholipid-transporting ATPase IB

0.80	GO:0045332	phospholipid translocation
0.48	GO:0061092	positive regulation of phospholipid translocation
0.43	GO:0007610	behavior
0.42	GO:0050890	cognition
0.42	GO:0030335	positive regulation of cell migration
0.41	GO:0048194	Golgi vesicle budding
0.40	GO:0048666	neuron development
0.40	GO:0003011	involuntary skeletal muscle contraction
0.39	GO:0060052	neurofilament cytoskeleton organization
0.39	GO:0050884	neuromuscular process controlling posture

0.81	GO:0004012	phospholipid-translocating ATPase activity
0.64	GO:0000287	magnesium ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0017056	structural constituent of nuclear pore
0.36	GO:0043565	sequence-specific DNA binding
0.33	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
0.33	GO:0005515	protein binding
0.32	GO:0009055	electron transfer activity

0.44	GO:0005794	Golgi apparatus
0.40	GO:0005783	endoplasmic reticulum
0.39	GO:0098588	bounding membrane of organelle
0.39	GO:0005886	plasma membrane
0.39	GO:0044446	intracellular organelle part
0.38	GO:0031410	cytoplasmic vesicle
0.38	GO:0005634	nucleus
0.37	GO:0043233	organelle lumen
0.36	GO:0001750	photoreceptor outer segment
0.35	GO:0031975	envelope

0.81

EC:3.6.3.1

GO:0004012

tr|T1EF43|T1EF43_HELRO
Uncharacterized protein
Search

0.73	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.50	GO:0007219	Notch signaling pathway
0.47	GO:0007275	multicellular organism development
0.40	GO:0060429	epithelium development
0.40	GO:0007276	gamete generation
0.40	GO:1990134	epithelial cell apoptotic process involved in palatal shelf morphogenesis
0.40	GO:0048729	tissue morphogenesis
0.40	GO:0003367	cell-cell adhesion involved in ameboidal cell migration
0.39	GO:0030154	cell differentiation
0.39	GO:0046629	gamma-delta T cell activation

0.70	GO:0005509	calcium ion binding
0.52	GO:0005112	Notch binding
0.38	GO:0001965	G-protein alpha-subunit binding
0.38	GO:0008083	growth factor activity
0.37	GO:0005540	hyaluronic acid binding
0.36	GO:0004930	G-protein coupled receptor activity
0.33	GO:0005201	extracellular matrix structural constituent
0.33	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0008144	drug binding

0.51	GO:0005886	plasma membrane
0.39	GO:0031594	neuromuscular junction
0.38	GO:0098857	membrane microdomain
0.38	GO:0030057	desmosome
0.38	GO:0005902	microvillus
0.37	GO:0005913	cell-cell adherens junction
0.37	GO:0005794	Golgi apparatus
0.36	GO:0005938	cell cortex
0.36	GO:0005829	cytosol
0.36	GO:0019898	extrinsic component of membrane

0.33

GO:0004714

tr|T1EF44|T1EF44_HELRO
Signal peptidase complex catalytic subunit SEC11
Search

SEC11A

0.72	Signal peptidase complex catalytic subunit SEC11

0.78	GO:0006465	signal peptide processing
0.35	GO:0006351	transcription, DNA-templated
0.34	GO:0018108	peptidyl-tyrosine phosphorylation

0.66	GO:0017171	serine hydrolase activity
0.61	GO:0070011	peptidase activity, acting on L-amino acid peptides
0.37	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.35	GO:0003723	RNA binding
0.34	GO:0004713	protein tyrosine kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.80	GO:0005787	signal peptidase complex
0.36	GO:0031090	organelle membrane
0.36	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.37

GO:0003899

tr|T1EF45|T1EF45_HELRO
Uncharacterized protein
Search

0.94	Tyrosine-protein kinase Lyn (Fragment)

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.70	GO:0070667	negative regulation of mast cell proliferation
0.70	GO:0060369	positive regulation of Fc receptor mediated stimulatory signaling pathway
0.70	GO:0002774	Fc receptor mediated inhibitory signaling pathway
0.70	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation
0.70	GO:0002553	histamine secretion by mast cell
0.70	GO:0070668	positive regulation of mast cell proliferation
0.70	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway
0.70	GO:2000670	positive regulation of dendritic cell apoptotic process
0.69	GO:0002513	tolerance induction to self antigen

0.77	GO:0004713	protein tyrosine kinase activity
0.70	GO:0140031	phosphorylation-dependent protein binding
0.69	GO:0043208	glycosphingolipid binding
0.66	GO:0005161	platelet-derived growth factor receptor binding
0.65	GO:0046875	ephrin receptor binding
0.64	GO:0044325	ion channel binding
0.64	GO:0005178	integrin binding
0.63	GO:0051219	phosphoprotein binding
0.62	GO:0043015	gamma-tubulin binding
0.61	GO:0017124	SH3 domain binding

0.69	GO:0034666	integrin alpha2-beta1 complex
0.66	GO:0042629	mast cell granule
0.66	GO:0030061	mitochondrial crista
0.63	GO:0014069	postsynaptic density
0.63	GO:0005913	cell-cell adherens junction
0.61	GO:0045121	membrane raft
0.61	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.60	GO:0005758	mitochondrial intermembrane space
0.60	GO:0048471	perinuclear region of cytoplasm
0.56	GO:0070062	extracellular exosome

0.77

GO:0004713

tr|T1EF46|T1EF46_HELRO
Uncharacterized protein
Search

ALG2

0.46	Asparagine-linked glycosylation 2

0.75	GO:0097502	mannosylation
0.71	GO:0006486	protein glycosylation
0.57	GO:0006490	oligosaccharide-lipid intermediate biosynthetic process
0.52	GO:0051592	response to calcium ion
0.34	GO:0035335	peptidyl-tyrosine dephosphorylation

0.82	GO:0000033	alpha-1,3-mannosyltransferase activity
0.53	GO:0048306	calcium-dependent protein binding
0.52	GO:0047485	protein N-terminus binding
0.48	GO:0046982	protein heterodimerization activity
0.45	GO:0004378	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
0.43	GO:0033164	glycolipid 6-alpha-mannosyltransferase activity
0.40	GO:0102704	GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity
0.34	GO:0004725	protein tyrosine phosphatase activity

0.50	GO:0005783	endoplasmic reticulum
0.50	GO:0048471	perinuclear region of cytoplasm
0.48	GO:0015629	actin cytoskeleton
0.46	GO:0005829	cytosol
0.46	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.44	GO:0005634	nucleus
0.44	GO:0031984	organelle subcompartment
0.30	GO:0031224	intrinsic component of membrane

0.82

GO:0000033

tr|T1EF47|T1EF47_HELRO
Uncharacterized protein
Search

FRMD4A

0.54	FERM domain containing 4A

0.55	GO:0090162	establishment of epithelial cell polarity
0.33	GO:0019538	protein metabolic process
0.32	GO:0043043	peptide biosynthetic process
0.32	GO:0010467	gene expression
0.32	GO:0009059	macromolecule biosynthetic process
0.32	GO:0044260	cellular macromolecule metabolic process

0.48	GO:0030674	protein binding, bridging
0.34	GO:0008092	cytoskeletal protein binding
0.33	GO:0004222	metalloendopeptidase activity
0.33	GO:0008270	zinc ion binding
0.32	GO:0003735	structural constituent of ribosome
0.32	GO:0003723	RNA binding

0.69	GO:0005856	cytoskeleton
0.52	GO:0005923	bicellular tight junction
0.44	GO:0005912	adherens junction
0.44	GO:0001726	ruffle
0.36	GO:0005737	cytoplasm
0.34	GO:0044421	extracellular region part
0.32	GO:0030529	intracellular ribonucleoprotein complex

0.33

GO:0004222

tr|T1EF48|T1EF48_HELRO
Uncharacterized protein
Search

0.56	Serine/threonine-protein kinase 10

0.63	GO:0006468	protein phosphorylation
0.48	GO:2000401	regulation of lymphocyte migration
0.48	GO:0071593	lymphocyte aggregation
0.47	GO:0001934	positive regulation of protein phosphorylation
0.46	GO:0007346	regulation of mitotic cell cycle
0.45	GO:0044784	metaphase/anaphase transition of cell cycle
0.44	GO:0031098	stress-activated protein kinase signaling cascade
0.44	GO:0000132	establishment of mitotic spindle orientation
0.43	GO:0030866	cortical actin cytoskeleton organization
0.43	GO:0007052	mitotic spindle organization

0.69	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0042803	protein homodimerization activity
0.38	GO:0005057	signal transducer activity, downstream of receptor
0.37	GO:0045296	cadherin binding
0.34	GO:0016907	G-protein coupled acetylcholine receptor activity
0.33	GO:0004499	N,N-dimethylaniline monooxygenase activity

0.44	GO:0097610	cell surface furrow
0.44	GO:1990023	mitotic spindle midzone
0.43	GO:0032155	cell division site part
0.41	GO:0005938	cell cortex
0.38	GO:0005886	plasma membrane
0.37	GO:0031252	cell leading edge
0.36	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0070062	extracellular exosome
0.34	GO:0035579	specific granule membrane
0.33	GO:0015934	large ribosomal subunit

0.69

GO:0004674

tr|T1EF49|T1EF49_HELRO
Amino acid transporter
Search

SLC1A1

0.45	Excitatory amino acid transporter

0.55	GO:0055085	transmembrane transport
0.51	GO:0070779	D-aspartate import
0.51	GO:0070778	L-aspartate transport
0.50	GO:1903802	L-glutamate(1-) import across plasma membrane
0.50	GO:0001504	neurotransmitter uptake
0.50	GO:0010460	positive regulation of heart rate
0.48	GO:0042883	cysteine transport
0.46	GO:0051260	protein homooligomerization
0.46	GO:0006821	chloride transport
0.40	GO:0008345	larval locomotory behavior

0.72	GO:0015293	symporter activity
0.52	GO:0033229	cysteine transmembrane transporter activity
0.50	GO:0005313	L-glutamate transmembrane transporter activity
0.46	GO:0015108	chloride transmembrane transporter activity
0.45	GO:0015081	sodium ion transmembrane transporter activity
0.43	GO:0022853	active ion transmembrane transporter activity
0.37	GO:0016595	glutamate binding
0.34	GO:0005515	protein binding
0.33	GO:0046872	metal ion binding

0.48	GO:0016324	apical plasma membrane
0.43	GO:0005887	integral component of plasma membrane
0.36	GO:0042995	cell projection
0.36	GO:0070062	extracellular exosome

tr|T1EF50|T1EF50_HELRO
Uncharacterized protein
Search

0.48	cAMP-dependent protein kinase catalytic subunit alpha

0.63	GO:0006468	protein phosphorylation
0.42	GO:0008359	regulation of bicoid mRNA localization
0.42	GO:0048682	sprouting of injured axon
0.41	GO:0007615	anesthesia-resistant memory
0.41	GO:0007228	positive regulation of hh target transcription factor activity
0.41	GO:0007448	anterior/posterior pattern specification, imaginal disc
0.41	GO:0008103	oocyte microtubule cytoskeleton polarization
0.41	GO:0007317	regulation of pole plasm oskar mRNA localization
0.41	GO:0040040	thermosensory behavior
0.41	GO:0008355	olfactory learning

0.70	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0060089	molecular transducer activity
0.33	GO:0005515	protein binding

0.39	GO:0030425	dendrite
0.39	GO:0044297	cell body
0.36	GO:0005952	cAMP-dependent protein kinase complex
0.35	GO:0005886	plasma membrane
0.34	GO:0005737	cytoplasm

0.70

GO:0004674

tr|T1EF51|T1EF51_HELRO
Uncharacterized protein
Search

0.33	GO:0009395	phospholipid catabolic process
0.33	GO:0006915	apoptotic process

0.74	GO:0008017	microtubule binding
0.62	GO:0005509	calcium ion binding
0.49	GO:0003779	actin binding
0.39	GO:0002162	dystroglycan binding
0.34	GO:0004622	lysophospholipase activity
0.32	GO:0005198	structural molecule activity

0.49	GO:0005856	cytoskeleton
0.33	GO:0099512	supramolecular fiber
0.32	GO:0044446	intracellular organelle part
0.30	GO:0044425	membrane part

0.34

EC:3.1.1.5

GO:0004622

tr|T1EF52|T1EF52_HELRO
Uncharacterized protein
Search

0.11	Putative transcription factor (Fragment)

0.72	GO:0045653	negative regulation of megakaryocyte differentiation
0.72	GO:1903351	cellular response to dopamine
0.62	GO:0000122	negative regulation of transcription by RNA polymerase II
0.62	GO:0006366	transcription by RNA polymerase II
0.61	GO:0045944	positive regulation of transcription by RNA polymerase II
0.59	GO:0001701	in utero embryonic development
0.50	GO:0030154	cell differentiation

0.68	GO:0033613	activating transcription factor binding
0.65	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0001012	RNA polymerase II regulatory region DNA binding
0.61	GO:0003682	chromatin binding
0.60	GO:0046982	protein heterodimerization activity
0.59	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.59	GO:0000785	chromatin
0.56	GO:0031974	membrane-enclosed lumen

tr|T1EF53|T1EF53_HELRO
Uncharacterized protein
Search

0.85	Phosphorylatable fast skeletal muscle myosin light chain

0.52	GO:0007519	skeletal muscle tissue development
0.38	GO:0001678	cellular glucose homeostasis
0.38	GO:0006955	immune response
0.37	GO:0006936	muscle contraction
0.37	GO:0046835	carbohydrate phosphorylation
0.36	GO:0006096	glycolytic process
0.34	GO:0036065	fucosylation
0.34	GO:0043413	macromolecule glycosylation
0.34	GO:0009101	glycoprotein biosynthetic process
0.34	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

0.69	GO:0005509	calcium ion binding
0.54	GO:0008307	structural constituent of muscle
0.38	GO:0005536	glucose binding
0.37	GO:0004396	hexokinase activity
0.35	GO:0030554	adenyl nucleotide binding
0.35	GO:0097367	carbohydrate derivative binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0008144	drug binding
0.34	GO:0008417	fucosyltransferase activity
0.34	GO:0003676	nucleic acid binding

0.47	GO:0031672	A band
0.47	GO:0043197	dendritic spine
0.43	GO:0016459	myosin complex
0.36	GO:0005765	lysosomal membrane
0.34	GO:0031428	box C/D snoRNP complex
0.34	GO:0005829	cytosol
0.34	GO:0032580	Golgi cisterna membrane
0.34	GO:0032040	small-subunit processome
0.33	GO:0019013	viral nucleocapsid
0.32	GO:0000786	nucleosome

0.37

EC:2.7.1.1

GO:0004396

tr|T1EF54|T1EF54_HELRO
Uncharacterized protein
Search

0.53	GO:0045035	sensory organ precursor cell division
0.52	GO:0061320	pericardial nephrocyte differentiation
0.52	GO:0061382	Malpighian tubule tip cell differentiation
0.52	GO:0042694	muscle cell fate specification
0.52	GO:0014019	neuroblast development
0.52	GO:0016360	sensory organ precursor cell fate determination
0.52	GO:0009786	regulation of asymmetric cell division
0.51	GO:0007406	negative regulation of neuroblast proliferation
0.51	GO:0055059	asymmetric neuroblast division
0.51	GO:0051642	centrosome localization

0.52	GO:0003924	GTPase activity
0.51	GO:0032550	purine ribonucleoside binding
0.51	GO:0019001	guanyl nucleotide binding
0.49	GO:0051117	ATPase binding
0.45	GO:0005230	extracellular ligand-gated ion channel activity
0.44	GO:0032555	purine ribonucleotide binding
0.44	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0003735	structural constituent of ribosome

0.48	GO:0016323	basolateral plasma membrane
0.46	GO:0005938	cell cortex
0.41	GO:0015935	small ribosomal subunit
0.30	GO:0016021	integral component of membrane

tr|T1EF55|T1EF55_HELRO
Uncharacterized protein
Search

TOM1L2 (1 OF MANY)

0.77	Target of Myb protein 1

0.69	GO:0006886	intracellular protein transport
0.35	GO:0016192	vesicle-mediated transport
0.30	GO:0008152	metabolic process

0.36	GO:0008410	CoA-transferase activity
0.35	GO:0030276	clathrin binding
0.32	GO:0046872	metal ion binding

0.45	GO:0005622	intracellular
0.36	GO:0048475	coated membrane
0.35	GO:0098796	membrane protein complex
0.34	GO:0031982	vesicle
0.34	GO:0012505	endomembrane system
0.31	GO:0071944	cell periphery
0.30	GO:0016021	integral component of membrane

0.36

EC:2.8.3

GO:0008410

tr|T1EF56|T1EF56_HELRO
Alpha-mannosidase
Search

MAN2A1

0.46	Alpha-mannosidase

0.81	GO:0006013	mannose metabolic process
0.51	GO:0006491	N-glycan processing
0.49	GO:0007585	respiratory gaseous exchange
0.49	GO:0048286	lung alveolus development
0.48	GO:0060042	retina morphogenesis in camera-type eye
0.48	GO:0001889	liver development
0.47	GO:0006517	protein deglycosylation
0.46	GO:0050769	positive regulation of neurogenesis
0.46	GO:0007033	vacuole organization
0.45	GO:0007005	mitochondrion organization

0.79	GO:0004559	alpha-mannosidase activity
0.69	GO:0030246	carbohydrate binding
0.53	GO:0046872	metal ion binding
0.44	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds

0.50	GO:0005797	Golgi medial cisterna
0.47	GO:0005801	cis-Golgi network
0.47	GO:0000139	Golgi membrane
0.44	GO:0005615	extracellular space
0.35	GO:0031982	vesicle
0.35	GO:0043230	extracellular organelle
0.34	GO:0005802	trans-Golgi network
0.30	GO:0016021	integral component of membrane

0.79

EC:3.2.1.24

GO:0004559

tr|T1EF57|T1EF57_HELRO
Uncharacterized protein
Search

0.43	Carbon-nitrogen hydrolase

0.45	GO:0006807	nitrogen compound metabolic process
0.37	GO:0042136	neurotransmitter biosynthetic process
0.36	GO:0044281	small molecule metabolic process
0.36	GO:0043562	cellular response to nitrogen levels
0.35	GO:0046700	heterocycle catabolic process
0.35	GO:1901361	organic cyclic compound catabolic process
0.35	GO:1901576	organic substance biosynthetic process
0.35	GO:0018130	heterocycle biosynthetic process
0.35	GO:0006725	cellular aromatic compound metabolic process
0.34	GO:0042737	drug catabolic process

0.46	GO:0003837	beta-ureidopropionase activity
0.34	GO:0004075	biotin carboxylase activity
0.34	GO:0046872	metal ion binding
0.33	GO:0003677	DNA binding
0.33	GO:0003735	structural constituent of ribosome
0.33	GO:0016746	transferase activity, transferring acyl groups
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.35	GO:0070062	extracellular exosome
0.35	GO:0005829	cytosol
0.34	GO:0005761	mitochondrial ribosome

0.46

EC:3.5.1.6

GO:0003837

tr|T1EF58|T1EF58_HELRO
Uncharacterized protein
Search

0.46	Alpha-aminoadipic semialdehyde synthase

0.53	GO:0055114	oxidation-reduction process
0.45	GO:0034969	histone arginine methylation
0.44	GO:0031060	regulation of histone methylation
0.40	GO:0006553	lysine metabolic process
0.38	GO:0009068	aspartate family amino acid catabolic process
0.37	GO:0009067	aspartate family amino acid biosynthetic process
0.37	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
0.37	GO:0042737	drug catabolic process
0.37	GO:0006367	transcription initiation from RNA polymerase II promoter
0.35	GO:0006091	generation of precursor metabolites and energy

0.54	GO:0016491	oxidoreductase activity
0.34	GO:0003677	DNA binding

0.36	GO:0043231	intracellular membrane-bounded organelle
0.35	GO:0005737	cytoplasm
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016020	membrane

0.54

GO:0016491

tr|T1EF59|T1EF59_HELRO
Uncharacterized protein
Search

tr|T1EF60|T1EF60_HELRO
Uncharacterized protein
Search

CANX

0.83

Calnexin

0.69	GO:0006457	protein folding
0.43	GO:0016063	rhodopsin biosynthetic process
0.41	GO:0001895	retina homeostasis
0.41	GO:0010522	regulation of calcium ion transport into cytosol
0.39	GO:0048488	synaptic vesicle endocytosis
0.37	GO:0072583	clathrin-dependent endocytosis
0.36	GO:0050821	protein stabilization
0.33	GO:0005975	carbohydrate metabolic process

0.71	GO:0051082	unfolded protein binding
0.70	GO:0005509	calcium ion binding
0.33	GO:0016758	transferase activity, transferring hexosyl groups

0.70	GO:0005783	endoplasmic reticulum
0.40	GO:0048471	perinuclear region of cytoplasm
0.38	GO:0044233	ER-mitochondrion membrane contact site
0.38	GO:0043209	myelin sheath
0.37	GO:0045202	synapse
0.37	GO:0044446	intracellular organelle part
0.37	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.35	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.33

GO:0016758

tr|T1EF61|T1EF61_HELRO
Uncharacterized protein
Search

ATAD2

0.74	ATPase family AAA domain-containing protein 2

0.66	GO:0006325	chromatin organization
0.53	GO:1903506	regulation of nucleic acid-templated transcription
0.53	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.52	GO:0010468	regulation of gene expression
0.44	GO:1902680	positive regulation of RNA biosynthetic process
0.43	GO:1902275	regulation of chromatin organization
0.41	GO:2001251	negative regulation of chromosome organization
0.36	GO:0044087	regulation of cellular component biogenesis
0.35	GO:0006635	fatty acid beta-oxidation
0.34	GO:0006351	transcription, DNA-templated

0.56	GO:0016887	ATPase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0042393	histone binding
0.41	GO:0003682	chromatin binding
0.36	GO:0140033	acetylation-dependent protein binding
0.35	GO:0004300	enoyl-CoA hydratase activity
0.34	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
0.34	GO:0046872	metal ion binding

0.42	GO:0005654	nucleoplasm
0.36	GO:0016507	mitochondrial fatty acid beta-oxidation multienzyme complex
0.34	GO:0070062	extracellular exosome
0.34	GO:0000790	nuclear chromatin
0.30	GO:0016020	membrane

0.56

GO:0016887

tr|T1EF62|T1EF62_HELRO
Uncharacterized protein
Search

0.91	LIM domain-containing protein E

0.60	GO:0035995	detection of muscle stretch
0.58	GO:0003300	cardiac muscle hypertrophy
0.57	GO:0055003	cardiac myofibril assembly
0.57	GO:0002026	regulation of the force of heart contraction
0.57	GO:0060048	cardiac muscle contraction
0.53	GO:0006874	cellular calcium ion homeostasis
0.51	GO:0045944	positive regulation of transcription by RNA polymerase II
0.50	GO:0033365	protein localization to organelle
0.40	GO:1903920	positive regulation of actin filament severing
0.39	GO:0007517	muscle organ development

0.60	GO:0031433	telethonin binding
0.58	GO:0008307	structural constituent of muscle
0.54	GO:0042805	actinin binding
0.54	GO:0046872	metal ion binding
0.50	GO:0042802	identical protein binding
0.38	GO:0003779	actin binding
0.37	GO:0043426	MRF binding
0.37	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding
0.36	GO:0003700	DNA binding transcription factor activity
0.35	GO:0003677	DNA binding

0.56	GO:0030018	Z disc
0.39	GO:0005634	nucleus
0.39	GO:0005667	transcription factor complex
0.37	GO:0005856	cytoskeleton
0.30	GO:0016020	membrane

tr|T1EF63|T1EF63_HELRO
Uncharacterized protein
Search

0.46	Cysteine protease domain, YopT-type

0.63	GO:0032259	methylation
0.45	GO:0035562	negative regulation of chromatin binding
0.45	GO:0040031	snRNA modification
0.44	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
0.42	GO:0000122	negative regulation of transcription by RNA polymerase II
0.35	GO:0044260	cellular macromolecule metabolic process
0.34	GO:0045905	positive regulation of translational termination
0.34	GO:0045901	positive regulation of translational elongation
0.34	GO:0006508	proteolysis
0.33	GO:0070868	heterochromatin organization involved in chromatin silencing

0.63	GO:0008168	methyltransferase activity
0.38	GO:0140098	catalytic activity, acting on RNA
0.34	GO:0008233	peptidase activity
0.34	GO:0003723	RNA binding
0.33	GO:0043022	ribosome binding
0.33	GO:0001085	RNA polymerase II transcription factor binding
0.33	GO:0046872	metal ion binding

0.34	GO:0005581	collagen trimer
0.32	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.63

GO:0008168

tr|T1EF64|T1EF64_HELRO
Uncharacterized protein
Search

0.39	Elongation factor G, mitochondrial

0.73	GO:0032790	ribosome disassembly
0.67	GO:0032543	mitochondrial translation
0.55	GO:0051881	regulation of mitochondrial membrane potential
0.53	GO:0000002	mitochondrial genome maintenance
0.48	GO:0006414	translational elongation
0.34	GO:0015991	ATP hydrolysis coupled proton transport
0.32	GO:0006413	translational initiation
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0003746	translation elongation factor activity
0.34	GO:0046961	proton-transporting ATPase activity, rotational mechanism
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0003743	translation initiation factor activity

0.53	GO:0005739	mitochondrion
0.34	GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
0.33	GO:0005840	ribosome
0.32	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

tr|T1EF65|T1EF65_HELRO
rRNA adenine N(6)-methyltransferase
Search

TFB1M

0.62	Mitochondrial dimethyladenosine transferase 1

0.72	GO:0031167	rRNA methylation
0.56	GO:0061817	endoplasmic reticulum-plasma membrane tethering
0.51	GO:0006869	lipid transport
0.36	GO:0006351	transcription, DNA-templated
0.36	GO:1903506	regulation of nucleic acid-templated transcription
0.36	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.36	GO:0010468	regulation of gene expression
0.34	GO:0006589	octopamine biosynthetic process
0.34	GO:0042420	dopamine catabolic process
0.34	GO:0042421	norepinephrine biosynthetic process

0.78	GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity
0.59	GO:0003723	RNA binding
0.49	GO:0008289	lipid binding
0.37	GO:0003924	GTPase activity
0.35	GO:0003677	DNA binding
0.34	GO:0004500	dopamine beta-monooxygenase activity
0.33	GO:0005507	copper ion binding
0.33	GO:0005515	protein binding

0.49	GO:0042645	mitochondrial nucleoid
0.34	GO:0030667	secretory granule membrane
0.33	GO:0005615	extracellular space
0.30	GO:0031224	intrinsic component of membrane

0.78	EC:2.1.1	GO:0000179
0.34	KEGG:R02535	GO:0004500

tr|T1EF66|T1EF66_HELRO
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit
Search

0.47	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit

0.76	GO:0036265	RNA (guanine-N7)-methylation
0.67	GO:0030488	tRNA methylation
0.35	GO:0006836	neurotransmitter transport
0.33	GO:0055085	transmembrane transport

0.50	GO:0008168	methyltransferase activity
0.38	GO:0140101	catalytic activity, acting on a tRNA
0.35	GO:0005328	neurotransmitter:sodium symporter activity

0.56	GO:0005634	nucleus
0.42	GO:0043527	tRNA methyltransferase complex
0.38	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.50

GO:0008168

tr|T1EF67|T1EF67_HELRO
Uncharacterized protein
Search

SLC7A9

0.77	large neutral amino acids transporter small subunit 1

0.55	GO:0055085	transmembrane transport
0.53	GO:0015804	neutral amino acid transport
0.52	GO:0015811	L-cystine transport
0.45	GO:0042940	D-amino acid transport
0.43	GO:0043090	amino acid import
0.42	GO:0050832	defense response to fungus
0.41	GO:0015803	branched-chain amino acid transport
0.40	GO:0015893	drug transport
0.40	GO:0006812	cation transport
0.34	GO:0050900	leukocyte migration

0.57	GO:0022857	transmembrane transporter activity
0.36	GO:0042605	peptide antigen binding
0.33	GO:0005515	protein binding

0.50	GO:0031526	brush border membrane
0.48	GO:0016324	apical plasma membrane
0.42	GO:0005887	integral component of plasma membrane
0.34	GO:0097440	apical dendrite
0.34	GO:0043025	neuronal cell body
0.33	GO:0005829	cytosol
0.32	GO:0043231	intracellular membrane-bounded organelle

tr|T1EF68|T1EF68_HELRO
Uncharacterized protein
Search

FRG1

0.95	FSHD region gene 1

0.63	GO:0070511	negative regulation of histone H4-K20 methylation
0.57	GO:0031936	negative regulation of chromatin silencing
0.47	GO:0007517	muscle organ development
0.43	GO:0006364	rRNA processing
0.40	GO:0008380	RNA splicing
0.39	GO:0006397	mRNA processing
0.35	GO:0043043	peptide biosynthetic process
0.34	GO:0044267	cellular protein metabolic process
0.34	GO:0009059	macromolecule biosynthetic process

0.68	GO:0051015	actin filament binding
0.40	GO:0003723	RNA binding
0.36	GO:0030246	carbohydrate binding
0.36	GO:0003735	structural constituent of ribosome

0.76	GO:0055120	striated muscle dense body
0.75	GO:0071013	catalytic step 2 spliceosome
0.64	GO:0005730	nucleolus
0.48	GO:0015030	Cajal body
0.48	GO:0030018	Z disc
0.35	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

tr|T1EF69|T1EF69_HELRO
Uncharacterized protein
Search

GNA13

0.74	Guanine nucleotide-binding protein subunit alpha

0.74	GO:0007264	small GTPase mediated signal transduction
0.69	GO:0007186	G-protein coupled receptor signaling pathway
0.46	GO:0002009	morphogenesis of an epithelium
0.46	GO:0072359	circulatory system development
0.45	GO:0009790	embryo development
0.44	GO:0043149	stress fiber assembly
0.44	GO:0031584	activation of phospholipase D activity
0.44	GO:0014003	oligodendrocyte development
0.44	GO:0019933	cAMP-mediated signaling
0.43	GO:0009826	unidimensional cell growth

0.78	GO:0031683	G-protein beta/gamma-subunit complex binding
0.77	GO:0001664	G-protein coupled receptor binding
0.66	GO:0003924	GTPase activity
0.64	GO:0032550	purine ribonucleoside binding
0.63	GO:0019001	guanyl nucleotide binding
0.62	GO:0004871	signal transducer activity
0.52	GO:0032555	purine ribonucleotide binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0045296	cadherin binding
0.35	GO:0005089	Rho guanyl-nucleotide exchange factor activity

0.44	GO:0005622	intracellular
0.43	GO:0031526	brush border membrane
0.40	GO:1905360	GTPase complex
0.40	GO:0019897	extrinsic component of plasma membrane
0.39	GO:0009898	cytoplasmic side of plasma membrane
0.37	GO:0098797	plasma membrane protein complex
0.37	GO:0005925	focal adhesion
0.37	GO:0031982	vesicle
0.37	GO:0043230	extracellular organelle
0.36	GO:0005615	extracellular space

tr|T1EF70|T1EF70_HELRO
Uncharacterized protein
Search

0.63	Nicotinic acetylcholine receptor subunit alpha 2

0.80	GO:0060079	excitatory postsynaptic potential
0.60	GO:0034220	ion transmembrane transport
0.49	GO:0035094	response to nicotine
0.47	GO:0007271	synaptic transmission, cholinergic
0.47	GO:0007274	neuromuscular synaptic transmission
0.38	GO:0006812	cation transport
0.37	GO:0001508	action potential
0.37	GO:0051291	protein heterooligomerization
0.37	GO:0030534	adult behavior
0.36	GO:0007626	locomotory behavior

0.83	GO:0022848	acetylcholine-gated cation-selective channel activity
0.70	GO:0099600	transmembrane receptor activity
0.47	GO:0042166	acetylcholine binding
0.32	GO:0005515	protein binding

0.79	GO:0045211	postsynaptic membrane
0.74	GO:0030054	cell junction
0.53	GO:0005892	acetylcholine-gated channel complex
0.35	GO:0009897	external side of plasma membrane

tr|T1EF71|T1EF71_HELRO
Uncharacterized protein
Search

ALG11

0.88	Asparagine-linked glycosylation protein 11

0.78	GO:0097502	mannosylation
0.51	GO:0033577	protein glycosylation in endoplasmic reticulum
0.50	GO:0006490	oligosaccharide-lipid intermediate biosynthetic process
0.40	GO:0009312	oligosaccharide biosynthetic process
0.32	GO:0071450	cellular response to oxygen radical
0.32	GO:0000303	response to superoxide
0.32	GO:0006801	superoxide metabolic process
0.32	GO:0098869	cellular oxidant detoxification
0.31	GO:0055114	oxidation-reduction process

0.85	GO:0004377	GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
0.32	GO:0004791	thioredoxin-disulfide reductase activity

0.72	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.85	EC:2.4.1.131	GO:0004377
0.32	KEGG:R02016	GO:0004791

tr|T1EF72|T1EF72_HELRO
Annexin
Search

ANXA4

0.60

Annexin

0.58	GO:0051241	negative regulation of multicellular organismal process
0.55	GO:2000482	regulation of interleukin-8 secretion
0.53	GO:0032088	negative regulation of NF-kappaB transcription factor activity
0.53	GO:0050818	regulation of coagulation
0.53	GO:0007219	Notch signaling pathway
0.53	GO:0050709	negative regulation of protein secretion
0.51	GO:0030855	epithelial cell differentiation
0.47	GO:0006357	regulation of transcription by RNA polymerase II
0.38	GO:0010033	response to organic substance
0.36	GO:0051560	mitochondrial calcium ion homeostasis

0.81	GO:0005544	calcium-dependent phospholipid binding
0.70	GO:0005509	calcium ion binding
0.55	GO:0051059	NF-kappaB binding
0.54	GO:0048306	calcium-dependent protein binding
0.49	GO:0042802	identical protein binding
0.37	GO:0008201	heparin binding
0.36	GO:0035374	chondroitin sulfate binding
0.36	GO:0015485	cholesterol binding
0.35	GO:0001786	phosphatidylserine binding
0.35	GO:0004859	phospholipase inhibitor activity

0.51	GO:0048471	perinuclear region of cytoplasm
0.51	GO:0009986	cell surface
0.51	GO:0031965	nuclear membrane
0.49	GO:0012506	vesicle membrane
0.42	GO:0072563	endothelial microparticle
0.42	GO:0005886	plasma membrane
0.39	GO:0098552	side of membrane
0.37	GO:0070062	extracellular exosome
0.36	GO:0045177	apical part of cell
0.36	GO:0044433	cytoplasmic vesicle part

tr|T1EF73|T1EF73_HELRO
Uncharacterized protein
Search

tr|T1EF74|T1EF74_HELRO
Uncharacterized protein
Search

RPS14

0.63	Ribosomal protein S14

0.57	GO:0043043	peptide biosynthetic process
0.53	GO:0044267	cellular protein metabolic process
0.51	GO:0010467	gene expression
0.50	GO:0030218	erythrocyte differentiation
0.50	GO:0009059	macromolecule biosynthetic process
0.47	GO:0000028	ribosomal small subunit assembly
0.44	GO:0000122	negative regulation of transcription by RNA polymerase II
0.43	GO:0061515	myeloid cell development
0.43	GO:0071695	anatomical structure maturation
0.42	GO:0048469	cell maturation

0.60	GO:0003735	structural constituent of ribosome
0.46	GO:0048027	mRNA 5'-UTR binding
0.46	GO:0045182	translation regulator activity
0.42	GO:0070181	small ribosomal subunit rRNA binding
0.35	GO:0042289	MHC class II protein binding

0.58	GO:0005840	ribosome
0.44	GO:0044445	cytosolic part
0.43	GO:0005730	nucleolus
0.39	GO:0005739	mitochondrion
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.35	GO:0031012	extracellular matrix
0.33	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

tr|T1EF75|T1EF75_HELRO
Uncharacterized protein
Search

0.10	CAP-Gly domain-containing linker protein 1

0.86	GO:0044861	protein transport into plasma membrane raft
0.83	GO:0031116	positive regulation of microtubule polymerization
0.78	GO:0001578	microtubule bundle formation
0.50	GO:0007349	cellularization
0.41	GO:1900006	positive regulation of dendrite development
0.39	GO:0007062	sister chromatid cohesion
0.39	GO:0000278	mitotic cell cycle
0.38	GO:0034968	histone lysine methylation

0.84	GO:0051010	microtubule plus-end binding
0.60	GO:0008270	zinc ion binding
0.53	GO:0070854	myosin VI heavy chain binding
0.45	GO:0003779	actin binding
0.44	GO:0042802	identical protein binding
0.40	GO:0046983	protein dimerization activity
0.38	GO:0018024	histone-lysine N-methyltransferase activity

0.85	GO:0044354	macropinosome
0.85	GO:0035371	microtubule plus-end
0.79	GO:0005881	cytoplasmic microtubule
0.74	GO:0005813	centrosome
0.72	GO:0005635	nuclear envelope
0.51	GO:0120025	plasma membrane bounded cell projection
0.51	GO:0045169	fusome
0.49	GO:0000776	kinetochore
0.48	GO:0005876	spindle microtubule
0.48	GO:0030427	site of polarized growth

0.38

GO:0018024

tr|T1EF76|T1EF76_HELRO
Uncharacterized protein
Search

0.63	GO:0032259	methylation
0.58	GO:0035562	negative regulation of chromatin binding
0.57	GO:0040031	snRNA modification
0.56	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
0.52	GO:0000122	negative regulation of transcription by RNA polymerase II
0.39	GO:0044260	cellular macromolecule metabolic process
0.34	GO:0036211	protein modification process
0.34	GO:0000154	rRNA modification

0.63	GO:0008168	methyltransferase activity
0.45	GO:0140098	catalytic activity, acting on RNA
0.35	GO:0003723	RNA binding
0.34	GO:0140096	catalytic activity, acting on a protein

0.63

GO:0008168

tr|T1EF77|T1EF77_HELRO
Queuine tRNA-ribosyltransferase catalytic subunit 1
Search

0.72	Queuine tRNA-ribosyltransferase catalytic subunit 1

0.78	GO:0101030	tRNA-guanine transglycosylation
0.36	GO:1902358	sulfate transmembrane transport
0.34	GO:0006813	potassium ion transport
0.33	GO:0008616	queuosine biosynthetic process
0.32	GO:0022900	electron transport chain

0.78	GO:0008479	queuine tRNA-ribosyltransferase activity
0.51	GO:0046872	metal ion binding
0.45	GO:0042803	protein homodimerization activity
0.45	GO:0046982	protein heterodimerization activity
0.36	GO:0015116	sulfate transmembrane transporter activity
0.33	GO:0015291	secondary active transmembrane transporter activity

0.56	GO:0005741	mitochondrial outer membrane
0.40	GO:0043234	protein complex
0.40	GO:0005634	nucleus
0.33	GO:0030964	NADH dehydrogenase complex
0.33	GO:0005746	mitochondrial respiratory chain
0.33	GO:1990204	oxidoreductase complex
0.30	GO:0016021	integral component of membrane

0.78

EC:2.4.2.29

GO:0008479

tr|T1EF78|T1EF78_HELRO
Uncharacterized protein
Search

LOC106161401

0.48	UDP-glucose:glycoprotein glucosyltransferase

0.61	GO:0098655	cation transmembrane transport
0.47	GO:0006882	cellular zinc ion homeostasis
0.47	GO:0010043	response to zinc ion
0.46	GO:0006829	zinc II ion transport
0.45	GO:0097501	stress response to metal ion
0.41	GO:0061088	regulation of sequestering of zinc ion
0.40	GO:0098660	inorganic ion transmembrane transport
0.40	GO:0098754	detoxification
0.36	GO:0030073	insulin secretion
0.35	GO:0009749	response to glucose

0.61	GO:0008324	cation transmembrane transporter activity
0.40	GO:0015562	efflux transmembrane transporter activity
0.40	GO:0015318	inorganic molecular entity transmembrane transporter activity
0.35	GO:0031491	nucleosome binding
0.34	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.33	GO:0004386	helicase activity
0.33	GO:0042803	protein homodimerization activity
0.33	GO:0016887	ATPase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0016740	transferase activity

0.43	GO:0016324	apical plasma membrane
0.38	GO:0031410	cytoplasmic vesicle
0.36	GO:0012505	endomembrane system
0.35	GO:0016323	basolateral plasma membrane
0.35	GO:0016589	NURF complex
0.35	GO:0012506	vesicle membrane
0.34	GO:0098805	whole membrane
0.34	GO:0098588	bounding membrane of organelle
0.30	GO:0016021	integral component of membrane

0.34

GO:0032440

tr|T1EF79|T1EF79_HELRO
Uncharacterized protein
Search

0.43	Kinase domain protein (Fragment)

0.63	GO:0006468	protein phosphorylation
0.56	GO:0019100	male germ-line sex determination
0.55	GO:0060718	chorionic trophoblast cell differentiation
0.55	GO:0010225	response to UV-C
0.55	GO:1904355	positive regulation of telomere capping
0.55	GO:1900745	positive regulation of p38MAPK cascade
0.54	GO:0051973	positive regulation of telomerase activity
0.54	GO:0032212	positive regulation of telomere maintenance via telomerase
0.54	GO:0043507	positive regulation of JUN kinase activity
0.53	GO:0000186	activation of MAPKK activity

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0005057	signal transducer activity, downstream of receptor
0.34	GO:0005515	protein binding
0.33	GO:0022857	transmembrane transporter activity
0.33	GO:0046872	metal ion binding
0.33	GO:0004222	metalloendopeptidase activity

0.38	GO:0005737	cytoplasm
0.35	GO:0043025	neuronal cell body
0.35	GO:0030424	axon
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.33

GO:0004222

tr|T1EF80|T1EF80_HELRO
Uncharacterized protein
Search

PLD6

0.90	MT associated signaling protein phospholipase D

0.70	GO:0010636	positive regulation of mitochondrial fusion
0.67	GO:0030719	P granule organization
0.66	GO:0008053	mitochondrial fusion
0.66	GO:0043046	DNA methylation involved in gamete generation
0.65	GO:0034587	piRNA metabolic process
0.62	GO:0007286	spermatid development
0.59	GO:0051321	meiotic cell cycle
0.40	GO:0006281	DNA repair
0.38	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

0.73	GO:0035755	cardiolipin hydrolase activity
0.59	GO:0042803	protein homodimerization activity
0.42	GO:0004630	phospholipase D activity
0.42	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity
0.38	GO:0004521	endoribonuclease activity
0.37	GO:0003677	DNA binding
0.37	GO:0046872	metal ion binding
0.35	GO:0003723	RNA binding

0.61	GO:0005741	mitochondrial outer membrane
0.30	GO:0031224	intrinsic component of membrane

0.42

EC:3.1.4.4

GO:0004630

tr|T1EF81|T1EF81_HELRO
Uncharacterized protein
Search

0.74	JmjC domain-containing histone demethylation protein 3C

0.48	GO:0032259	methylation
0.44	GO:1900113	negative regulation of histone H3-K9 trimethylation
0.43	GO:0070544	histone H3-K36 demethylation
0.43	GO:0033169	histone H3-K9 demethylation
0.40	GO:0003299	muscle hypertrophy in response to stress
0.40	GO:0014887	cardiac muscle adaptation
0.40	GO:0003300	cardiac muscle hypertrophy
0.37	GO:0010507	negative regulation of autophagy
0.37	GO:0045892	negative regulation of transcription, DNA-templated
0.36	GO:0035335	peptidyl-tyrosine dephosphorylation

0.48	GO:0008168	methyltransferase activity
0.48	GO:0046872	metal ion binding
0.43	GO:0032454	histone demethylase activity (H3-K9 specific)
0.41	GO:0051864	histone demethylase activity (H3-K36 specific)
0.39	GO:0035064	methylated histone binding
0.38	GO:0031625	ubiquitin protein ligase binding
0.37	GO:0004181	metallocarboxypeptidase activity
0.36	GO:0004725	protein tyrosine phosphatase activity
0.34	GO:0003677	DNA binding

0.61	GO:0005634	nucleus
0.42	GO:0005721	pericentric heterochromatin
0.39	GO:0005829	cytosol
0.38	GO:0031974	membrane-enclosed lumen
0.30	GO:0031224	intrinsic component of membrane

0.48

GO:0008168

tr|T1EF82|T1EF82_HELRO
Uncharacterized protein
Search

0.67	LOW QUALITY PROTEIN: coiled-coil domain-containing protein 6

0.44	GO:0007165	signal transduction
0.39	GO:0055085	transmembrane transport
0.37	GO:0007010	cytoskeleton organization

0.42	GO:0017124	SH3 domain binding
0.38	GO:0005200	structural constituent of cytoskeleton

0.62	GO:0005829	cytosol
0.40	GO:0005856	cytoskeleton
0.30	GO:0016020	membrane

tr|T1EF83|T1EF83_HELRO
Uncharacterized protein
Search

TMEM189

0.57	Ubiquitin conjugating enzyme

0.46	GO:0016567	protein ubiquitination
0.37	GO:0006301	postreplication repair
0.32	GO:0055114	oxidation-reduction process

0.49	GO:0031625	ubiquitin protein ligase binding
0.47	GO:0061630	ubiquitin protein ligase activity
0.35	GO:0080132	fatty acid alpha-hydroxylase activity

0.43	GO:0005783	endoplasmic reticulum
0.38	GO:0005654	nucleoplasm
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.35	GO:0031984	organelle subcompartment
0.30	GO:0044425	membrane part

tr|T1EF84|T1EF84_HELRO
Uncharacterized protein
Search

VPS8

0.83	Vacuolar protein sorting-associated protein 8

0.67	GO:0016192	vesicle-mediated transport
0.64	GO:0006886	intracellular protein transport
0.51	GO:0090174	organelle membrane fusion
0.49	GO:0016050	vesicle organization

0.40	GO:0046872	metal ion binding
0.37	GO:0005515	protein binding

0.53	GO:0033263	CORVET complex
0.50	GO:0005769	early endosome

tr|T1EF85|T1EF85_HELRO
Uncharacterized protein
Search

0.57	GO:0016567	protein ubiquitination
0.48	GO:0030513	positive regulation of BMP signaling pathway
0.47	GO:0042147	retrograde transport, endosome to Golgi
0.37	GO:0018108	peptidyl-tyrosine phosphorylation
0.35	GO:0055114	oxidation-reduction process

0.59	GO:0061630	ubiquitin protein ligase activity
0.58	GO:0031625	ubiquitin protein ligase binding
0.53	GO:0016874	ligase activity
0.49	GO:0061631	ubiquitin conjugating enzyme activity
0.38	GO:1901265	nucleoside phosphate binding
0.38	GO:0043168	anion binding
0.38	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.38	GO:0036094	small molecule binding
0.38	GO:0097367	carbohydrate derivative binding
0.38	GO:0008144	drug binding

0.46	GO:0016604	nuclear body
0.43	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.53

GO:0016874

tr|T1EF86|T1EF86_HELRO
Uncharacterized protein
Search

CNOT4

0.64	CCR4-NOT transcription complex subunit 4

0.45	GO:0046427	positive regulation of JAK-STAT cascade
0.41	GO:0016567	protein ubiquitination
0.39	GO:0006457	protein folding
0.38	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

0.59	GO:0003723	RNA binding
0.54	GO:0046872	metal ion binding
0.41	GO:0004842	ubiquitin-protein transferase activity
0.39	GO:0051082	unfolded protein binding

0.41	GO:0016272	prefoldin complex
0.40	GO:0030014	CCR4-NOT complex
0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.41

KEGG:R03876

GO:0004842

tr|T1EF87|T1EF87_HELRO
Uncharacterized protein
Search

0.71	GO:0006006	glucose metabolic process
0.68	GO:0006098	pentose-phosphate shunt
0.53	GO:0055114	oxidation-reduction process
0.38	GO:0042542	response to hydrogen peroxide
0.35	GO:0097305	response to alcohol
0.33	GO:0098656	anion transmembrane transport
0.33	GO:0006468	protein phosphorylation

0.79	GO:0004345	glucose-6-phosphate dehydrogenase activity
0.70	GO:0050661	NADP binding
0.60	GO:0017057	6-phosphogluconolactonase activity
0.34	GO:0030246	carbohydrate binding
0.34	GO:0008308	voltage-gated anion channel activity
0.33	GO:0004674	protein serine/threonine kinase activity
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0043168	anion binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0008144	drug binding

0.34	GO:0005739	mitochondrion
0.34	GO:0031968	organelle outer membrane
0.30	GO:0016021	integral component of membrane

0.79	EC:1.1.1.49	GO:0004345
0.60	KEGG:R02035	GO:0017057

tr|T1EF88|T1EF88_HELRO
Uncharacterized protein
Search

DNAAF5

0.78	Dynein axonemal assembly factor 5

0.85	GO:0036158	outer dynein arm assembly
0.85	GO:0036159	inner dynein arm assembly
0.83	GO:0003341	cilium movement

0.85

GO:0045505

dynein intermediate chain binding

0.49	GO:0005737	cytoplasm
0.41	GO:0031514	motile cilium
0.30	GO:0031224	intrinsic component of membrane

tr|T1EF89|T1EF89_HELRO
Uncharacterized protein
Search

CNOT8

0.68	CCR4-NOT transcription complex subunit

0.46	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
0.45	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
0.44	GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic
0.41	GO:0017148	negative regulation of translation
0.41	GO:0006351	transcription, DNA-templated
0.39	GO:0048666	neuron development
0.37	GO:0002213	defense response to insect
0.35	GO:0009611	response to wounding
0.35	GO:0042742	defense response to bacterium
0.32	GO:2001141	regulation of RNA biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.48	GO:0004535	poly(A)-specific ribonuclease activity
0.35	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding
0.32	GO:0016740	transferase activity

0.46	GO:0030015	CCR4-NOT core complex
0.43	GO:0000932	P-body
0.32	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.48

EC:3.1.13.4

GO:0004535

tr|T1EF90|T1EF90_HELRO
Uncharacterized protein
Search

0.50	neurobeachin-like protein 1

tr|T1EF91|T1EF91_HELRO
Uncharacterized protein
Search

WDR44

0.54	WD repeat-containing protein 44

0.38	GO:0030334	regulation of cell migration
0.36	GO:0019221	cytokine-mediated signaling pathway
0.36	GO:0007264	small GTPase mediated signal transduction
0.35	GO:0065009	regulation of molecular function

0.39	GO:0051020	GTPase binding
0.37	GO:0004896	cytokine receptor activity
0.35	GO:0098772	molecular function regulator

0.71	GO:0005794	Golgi apparatus
0.48	GO:0048471	perinuclear region of cytoplasm
0.47	GO:0010008	endosome membrane
0.44	GO:0005829	cytosol
0.37	GO:0005874	microtubule
0.30	GO:0031224	intrinsic component of membrane

tr|T1EF92|T1EF92_HELRO
Uncharacterized protein
Search

0.70	Yip1 interacting factor homolog A (S. cerevisiae)

0.43	GO:0006888	ER to Golgi vesicle-mediated transport
0.40	GO:0000902	cell morphogenesis
0.39	GO:0009306	protein secretion
0.33	GO:0006357	regulation of transcription by RNA polymerase II
0.33	GO:0006508	proteolysis

0.33	GO:0004252	serine-type endopeptidase activity
0.33	GO:0003700	DNA binding transcription factor activity
0.32	GO:0003677	DNA binding

0.45	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.44	GO:0030173	integral component of Golgi membrane
0.43	GO:0030134	COPII-coated ER to Golgi transport vesicle
0.41	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0005634	nucleus

0.33

GO:0004252

tr|T1EF93|T1EF93_HELRO
Uncharacterized protein
Search

0.69	GO:0034765	regulation of ion transmembrane transport
0.65	GO:0071805	potassium ion transmembrane transport
0.45	GO:0090333	regulation of stomatal closure
0.45	GO:0001101	response to acid chemical
0.44	GO:0048767	root hair elongation
0.43	GO:1901700	response to oxygen-containing compound
0.43	GO:0009651	response to salt stress
0.41	GO:0051716	cellular response to stimulus
0.40	GO:2000031	regulation of salicylic acid mediated signaling pathway
0.40	GO:0010035	response to inorganic substance

0.69	GO:0005249	voltage-gated potassium channel activity
0.42	GO:0099094	ligand-gated cation channel activity
0.41	GO:0042802	identical protein binding
0.38	GO:0003700	DNA binding transcription factor activity
0.38	GO:0004674	protein serine/threonine kinase activity
0.38	GO:0042578	phosphoric ester hydrolase activity
0.37	GO:0004871	signal transducer activity
0.37	GO:0004067	asparaginase activity
0.36	GO:0016849	phosphorus-oxygen lyase activity
0.36	GO:0070001	aspartic-type peptidase activity

0.37	GO:0005887	integral component of plasma membrane
0.34	GO:0005622	intracellular

0.38

GO:0004674

tr|T1EF94|T1EF94_HELRO
Uncharacterized protein
Search

0.89

Netrin

0.53	GO:0050770	regulation of axonogenesis
0.52	GO:0061387	regulation of extent of cell growth
0.52	GO:0007411	axon guidance
0.51	GO:0021960	anterior commissure morphogenesis
0.51	GO:0048638	regulation of developmental growth
0.48	GO:0016358	dendrite development
0.47	GO:0009887	animal organ morphogenesis
0.46	GO:0048568	embryonic organ development
0.46	GO:0048598	embryonic morphogenesis
0.45	GO:0051093	negative regulation of developmental process

0.36	GO:0005515	protein binding
0.33	GO:0004386	helicase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003676	nucleic acid binding

0.65	GO:0005576	extracellular region
0.37	GO:0030424	axon
0.35	GO:0005737	cytoplasm
0.32	GO:0071944	cell periphery
0.30	GO:0016020	membrane

tr|T1EF95|T1EF95_HELRO
Uncharacterized protein
Search

0.57	WD repeat-containing protein 55

0.66	GO:0009960	endosperm development
0.65	GO:0080186	developmental vegetative growth
0.64	GO:0010197	polar nucleus fusion
0.61	GO:0009793	embryo development ending in seed dormancy
0.60	GO:0042273	ribosomal large subunit biogenesis
0.60	GO:0009855	determination of bilateral symmetry
0.55	GO:0006364	rRNA processing
0.40	GO:0007030	Golgi organization
0.39	GO:0030010	establishment of cell polarity
0.39	GO:0016477	cell migration

0.43	GO:0016905	myosin heavy chain kinase activity
0.39	GO:0043531	ADP binding
0.38	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.36	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.36	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
0.35	GO:0003676	nucleic acid binding
0.35	GO:0005524	ATP binding

0.50	GO:0005634	nucleus
0.42	GO:0005737	cytoplasm
0.40	GO:0012505	endomembrane system
0.39	GO:0031974	membrane-enclosed lumen
0.37	GO:0043232	intracellular non-membrane-bounded organelle
0.37	GO:0044446	intracellular organelle part
0.36	GO:0043234	protein complex
0.34	GO:1905369	endopeptidase complex
0.30	GO:0031224	intrinsic component of membrane

0.43

GO:0016905

tr|T1EF96|T1EF96_HELRO
Uncharacterized protein
Search

0.63	GO:0006468	protein phosphorylation
0.54	GO:0000186	activation of MAPKK activity
0.48	GO:0007165	signal transduction
0.48	GO:0018212	peptidyl-tyrosine modification
0.46	GO:0071469	cellular response to alkaline pH
0.43	GO:0043507	positive regulation of JUN kinase activity
0.42	GO:0000187	activation of MAPK activity
0.40	GO:0048804	imaginal disc-derived female genitalia morphogenesis
0.40	GO:0007394	dorsal closure, elongation of leading edge cells
0.39	GO:0048803	imaginal disc-derived male genitalia morphogenesis

0.64	GO:0004672	protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0005057	signal transducer activity, downstream of receptor
0.44	GO:0004888	transmembrane signaling receptor activity
0.35	GO:0005080	protein kinase C binding
0.35	GO:0097110	scaffold protein binding
0.35	GO:0030971	receptor tyrosine kinase binding

0.40	GO:0005887	integral component of plasma membrane
0.37	GO:0005622	intracellular
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0043234	protein complex
0.32	GO:0044422	organelle part
0.32	GO:0043227	membrane-bounded organelle

0.32

GO:0004553

tr|T1EF97|T1EF97_HELRO
Uncharacterized protein
Search

tr|T1EF98|T1EF98_HELRO
Uncharacterized protein
Search

MCM8

0.94	DNA replication licensing factor MCM8

0.75	GO:0006270	DNA replication initiation
0.51	GO:0007292	female gamete generation
0.51	GO:0048232	male gamete generation
0.50	GO:0000724	double-strand break repair via homologous recombination
0.37	GO:0007049	cell cycle
0.33	GO:0008654	phospholipid biosynthetic process
0.33	GO:0042254	ribosome biogenesis

0.55	GO:0032559	adenyl ribonucleotide binding
0.55	GO:0003677	DNA binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0004386	helicase activity
0.34	GO:0016780	phosphotransferase activity, for other substituted phosphate groups
0.33	GO:0005515	protein binding

0.58	GO:0097362	MCM8-MCM9 complex
0.47	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.34

EC:2.7.8

GO:0016780

tr|T1EF99|T1EF99_HELRO
Uncharacterized protein
Search

0.67	Potassium channel subfamily T member 1

0.71	GO:0006813	potassium ion transport
0.40	GO:0098662	inorganic cation transmembrane transport
0.39	GO:0032259	methylation
0.35	GO:0101030	tRNA-guanine transglycosylation

0.49	GO:0005228	intracellular sodium activated potassium channel activity
0.45	GO:0015269	calcium-activated potassium channel activity
0.39	GO:0008168	methyltransferase activity
0.37	GO:0005249	voltage-gated potassium channel activity
0.36	GO:0003676	nucleic acid binding
0.35	GO:0008479	queuine tRNA-ribosyltransferase activity
0.33	GO:0046872	metal ion binding

0.37	GO:0008076	voltage-gated potassium channel complex
0.35	GO:0005741	mitochondrial outer membrane

0.39

GO:0008168

tr|T1EFA0|T1EFA0_HELRO
Uncharacterized protein
Search

HECTD1

0.71	HECT domain containing 1

0.73	GO:0016567	protein ubiquitination
0.34	GO:0010951	negative regulation of endopeptidase activity
0.34	GO:0006508	proteolysis
0.34	GO:0043632	modification-dependent macromolecule catabolic process
0.33	GO:0044257	cellular protein catabolic process

0.74	GO:0004842	ubiquitin-protein transferase activity
0.53	GO:0046872	metal ion binding
0.51	GO:0016874	ligase activity
0.36	GO:0061659	ubiquitin-like protein ligase activity
0.35	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.34	GO:0008234	cysteine-type peptidase activity

0.33	GO:0005634	nucleus
0.33	GO:0005737	cytoplasm

0.51	EC:6	GO:0016874
0.74	KEGG:R03876	GO:0004842

tr|T1EFA1|T1EFA1_HELRO
Uncharacterized protein
Search

CWH43

0.97	Cell wall biogenesis 43 C-terminal homolog

0.40	GO:0006506	GPI anchor biosynthetic process
0.39	GO:0031505	fungal-type cell wall organization

0.31

GO:0003677

DNA binding

0.39	GO:0005934	cellular bud tip
0.39	GO:0005935	cellular bud neck
0.36	GO:0005887	integral component of plasma membrane
0.33	GO:0005789	endoplasmic reticulum membrane
0.32	GO:0005634	nucleus

tr|T1EFA2|T1EFA2_HELRO
Uncharacterized protein
Search

0.60	Neuropeptide Y receptor

0.78	GO:0007218	neuropeptide signaling pathway
0.74	GO:2000479	regulation of cAMP-dependent protein kinase activity
0.72	GO:0045761	regulation of adenylate cyclase activity
0.66	GO:0043408	regulation of MAPK cascade
0.45	GO:1901652	response to peptide
0.43	GO:0032870	cellular response to hormone stimulus
0.39	GO:0007631	feeding behavior
0.37	GO:0042445	hormone metabolic process
0.36	GO:0007268	chemical synaptic transmission
0.34	GO:0007565	female pregnancy

0.80	GO:0008188	neuropeptide receptor activity
0.75	GO:0031628	opioid receptor binding
0.44	GO:0042277	peptide binding
0.32	GO:0008502	melatonin receptor activity

0.44	GO:0015629	actin cytoskeleton
0.41	GO:0005887	integral component of plasma membrane
0.33	GO:0043005	neuron projection

tr|T1EFA3|T1EFA3_HELRO
Uncharacterized protein
Search

0.60	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.60	GO:0038084	vascular endothelial growth factor signaling pathway
0.57	GO:0018108	peptidyl-tyrosine phosphorylation
0.49	GO:0035023	regulation of Rho protein signal transduction
0.44	GO:0065009	regulation of molecular function
0.43	GO:0048739	cardiac muscle fiber development
0.42	GO:0033334	fin morphogenesis
0.42	GO:0071711	basement membrane organization
0.40	GO:0030334	regulation of cell migration
0.40	GO:0051493	regulation of cytoskeleton organization

0.60	GO:0005021	vascular endothelial growth factor-activated receptor activity
0.49	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.45	GO:0032559	adenyl ribonucleotide binding
0.45	GO:0008144	drug binding
0.45	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0008307	structural constituent of muscle
0.40	GO:0051015	actin filament binding
0.38	GO:0005509	calcium ion binding

0.50	GO:0005887	integral component of plasma membrane
0.42	GO:0030018	Z disc

tr|T1EFA4|T1EFA4_HELRO
Uncharacterized protein
Search

0.53	Transcriptional activator cubitus interruptus

0.71	GO:0007224	smoothened signaling pathway
0.68	GO:0009953	dorsal/ventral pattern formation
0.65	GO:0009952	anterior/posterior pattern specification
0.64	GO:0048568	embryonic organ development
0.51	GO:0008284	positive regulation of cell proliferation
0.50	GO:0006355	regulation of transcription, DNA-templated
0.50	GO:1903508	positive regulation of nucleic acid-templated transcription
0.49	GO:0010628	positive regulation of gene expression
0.49	GO:0060573	cell fate specification involved in pattern specification
0.49	GO:0021514	ventral spinal cord interneuron differentiation

0.52	GO:0003700	DNA binding transcription factor activity
0.51	GO:0003676	nucleic acid binding
0.47	GO:0035035	histone acetyltransferase binding
0.46	GO:0042826	histone deacetylase binding
0.46	GO:0008013	beta-catenin binding
0.44	GO:0003682	chromatin binding
0.35	GO:0042803	protein homodimerization activity
0.34	GO:0008134	transcription factor binding
0.34	GO:0004252	serine-type endopeptidase activity
0.34	GO:0046872	metal ion binding

0.46	GO:0005930	axoneme
0.45	GO:0016607	nuclear speck
0.44	GO:0017053	transcriptional repressor complex
0.44	GO:0016592	mediator complex
0.42	GO:0005829	cytosol
0.40	GO:0035301	Hedgehog signaling complex
0.37	GO:0097542	ciliary tip
0.35	GO:0031514	motile cilium
0.34	GO:0005730	nucleolus
0.30	GO:0016020	membrane

0.34

GO:0004252

tr|T1EFA5|T1EFA5_HELRO
Rhomboid-like protein
Search

0.48	Inactive rhomboid protein 1

0.61	GO:0006508	proteolysis
0.45	GO:0042058	regulation of epidermal growth factor receptor signaling pathway
0.44	GO:0050709	negative regulation of protein secretion
0.41	GO:0061136	regulation of proteasomal protein catabolic process
0.41	GO:0008283	cell proliferation
0.40	GO:0016477	cell migration
0.40	GO:0051604	protein maturation
0.37	GO:0015031	protein transport

0.69	GO:0004252	serine-type endopeptidase activity
0.39	GO:0019838	growth factor binding

0.41	GO:0005789	endoplasmic reticulum membrane
0.40	GO:0000139	Golgi membrane
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0004252

tr|T1EFA6|T1EFA6_HELRO
Uncharacterized protein
Search

0.66	Peptide transporter family 1

0.78	GO:0006857	oligopeptide transport
0.55	GO:0055085	transmembrane transport
0.36	GO:2000192	negative regulation of fatty acid transport
0.36	GO:0040010	positive regulation of growth rate
0.36	GO:0080144	amino acid homeostasis
0.36	GO:1900101	regulation of endoplasmic reticulum unfolded protein response
0.36	GO:0040018	positive regulation of multicellular organism growth
0.36	GO:0002119	nematode larval development
0.35	GO:0008340	determination of adult lifespan
0.35	GO:0019915	lipid storage

0.57	GO:0022857	transmembrane transporter activity
0.41	GO:0015197	peptide transporter activity

0.35	GO:0016324	apical plasma membrane
0.34	GO:0005903	brush border
0.30	GO:0016021	integral component of membrane

tr|T1EFA7|T1EFA7_HELRO
Uncharacterized protein
Search

0.10	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (Fragment)

0.77	GO:0034968	histone lysine methylation
0.40	GO:0001501	skeletal system development
0.39	GO:0003290	atrial septum secundum morphogenesis
0.39	GO:0003289	atrial septum primum morphogenesis
0.39	GO:0048298	positive regulation of isotype switching to IgA isotypes
0.39	GO:0003149	membranous septum morphogenesis
0.39	GO:2001032	regulation of double-strand break repair via nonhomologous end joining
0.37	GO:0061448	connective tissue development
0.37	GO:0070201	regulation of establishment of protein localization
0.37	GO:0000122	negative regulation of transcription by RNA polymerase II

0.77	GO:0018024	histone-lysine N-methyltransferase activity
0.54	GO:0046872	metal ion binding
0.39	GO:0003677	DNA binding
0.37	GO:0003682	chromatin binding

0.60

GO:0005634

nucleus

0.77

GO:0018024

tr|T1EFA8|T1EFA8_HELRO
Uncharacterized protein
Search

0.11	Brain tumor protein

0.52	GO:0007281	germ cell development
0.51	GO:0051321	meiotic cell cycle
0.39	GO:0016567	protein ubiquitination

0.63	GO:0008270	zinc ion binding
0.39	GO:0004842	ubiquitin-protein transferase activity
0.36	GO:0016874	ligase activity
0.33	GO:0003676	nucleic acid binding

0.45

GO:0005622

intracellular

0.36	EC:6	GO:0016874
0.39	KEGG:R03876	GO:0004842

tr|T1EFA9|T1EFA9_HELRO
Uncharacterized protein
Search

0.70

Fimbrin

0.41	GO:0051639	actin filament network formation
0.41	GO:0051764	actin crosslink formation
0.40	GO:0051017	actin filament bundle assembly
0.38	GO:0016321	female meiosis chromosome segregation
0.33	GO:0009435	NAD biosynthetic process
0.32	GO:0006351	transcription, DNA-templated

0.73	GO:0003779	actin binding
0.65	GO:0005509	calcium ion binding
0.58	GO:0032403	protein complex binding
0.34	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity
0.33	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.32	GO:0003677	DNA binding

0.40	GO:0032432	actin filament bundle
0.40	GO:0005884	actin filament
0.38	GO:0045179	apical cortex
0.37	GO:0070938	contractile ring
0.35	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.34	EC:2.4.2.19	GO:0004514
0.34	KEGG:R03348	GO:0004514

tr|T1EFB0|T1EFB0_HELRO
Uncharacterized protein
Search

0.55	GO:0055085	transmembrane transport
0.48	GO:0015695	organic cation transport
0.45	GO:0015874	norepinephrine transport
0.44	GO:1901374	acetate ester transport
0.44	GO:0015696	ammonium transport
0.44	GO:0006820	anion transport
0.40	GO:0006836	neurotransmitter transport
0.40	GO:0015893	drug transport
0.39	GO:0051597	response to methylmercury
0.39	GO:0009437	carnitine metabolic process

0.56	GO:0022857	transmembrane transporter activity
0.41	GO:0005326	neurotransmitter transporter activity
0.37	GO:0030165	PDZ domain binding
0.35	GO:0042803	protein homodimerization activity
0.32	GO:0004815	aspartate-tRNA ligase activity
0.32	GO:0008270	zinc ion binding
0.32	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
0.32	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.32	GO:0003677	DNA binding
0.31	GO:0030554	adenyl nucleotide binding

0.42	GO:0005887	integral component of plasma membrane
0.41	GO:0098590	plasma membrane region
0.38	GO:0045177	apical part of cell
0.36	GO:0005903	brush border
0.35	GO:0120038	plasma membrane bounded cell projection part
0.34	GO:0070062	extracellular exosome
0.32	GO:0043231	intracellular membrane-bounded organelle
0.32	GO:0044444	cytoplasmic part

0.32

EC:6.1.1.12

GO:0004815

tr|T1EFB1|T1EFB1_HELRO
Enhancer of polycomb-like protein
Search

0.45	Enhancer of polycomb homolog

0.70	GO:0006357	regulation of transcription by RNA polymerase II
0.57	GO:0006351	transcription, DNA-templated
0.44	GO:0016573	histone acetylation
0.40	GO:0060319	primitive erythrocyte differentiation
0.35	GO:0006281	DNA repair
0.34	GO:0045814	negative regulation of gene expression, epigenetic
0.34	GO:0045893	positive regulation of transcription, DNA-templated
0.33	GO:0045892	negative regulation of transcription, DNA-templated

0.45

GO:0004402

histone acetyltransferase activity

0.84	GO:0032777	Piccolo NuA4 histone acetyltransferase complex
0.34	GO:0031965	nuclear membrane
0.30	GO:0016021	integral component of membrane

0.45

GO:0004402

tr|T1EFB2|T1EFB2_HELRO
Uncharacterized protein
Search

tr|T1EFB3|T1EFB3_HELRO
Uncharacterized protein
Search

CTH

0.59	Cystathionine gamma-lyase inhibitor

0.51	GO:0019346	transsulfuration
0.50	GO:0044524	protein sulfhydration
0.50	GO:0018272	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
0.49	GO:0019343	cysteine biosynthetic process via cystathionine
0.49	GO:1904831	positive regulation of aortic smooth muscle cell differentiation
0.46	GO:0051289	protein homotetramerization
0.45	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.45	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.45	GO:1990823	response to leukemia inhibitory factor
0.45	GO:2001234	negative regulation of apoptotic signaling pathway

0.67	GO:0030170	pyridoxal phosphate binding
0.57	GO:0016829	lyase activity
0.44	GO:0003962	cystathionine gamma-synthase activity
0.43	GO:0042802	identical protein binding
0.34	GO:0005516	calmodulin binding

0.35

GO:0005737

cytoplasm

0.57

EC:4

GO:0016829

tr|T1EFB4|T1EFB4_HELRO
Uncharacterized protein
Search

0.10	Atrial natriuretic peptide-converting enzyme (Fragment)

0.70	GO:0016486	peptide hormone processing
0.56	GO:0003050	regulation of systemic arterial blood pressure by atrial natriuretic peptide
0.55	GO:0035813	regulation of renal sodium excretion
0.50	GO:0007565	female pregnancy
0.47	GO:0006898	receptor-mediated endocytosis
0.37	GO:0030154	cell differentiation
0.37	GO:0007275	multicellular organism development
0.37	GO:0060429	epithelium development
0.36	GO:0003006	developmental process involved in reproduction
0.36	GO:0048646	anatomical structure formation involved in morphogenesis

0.61	GO:0004252	serine-type endopeptidase activity
0.50	GO:0005044	scavenger receptor activity
0.45	GO:0005509	calcium ion binding
0.34	GO:0004930	G-protein coupled receptor activity
0.34	GO:0005230	extracellular ligand-gated ion channel activity
0.33	GO:0008061	chitin binding
0.33	GO:0017147	Wnt-protein binding
0.33	GO:0042813	Wnt-activated receptor activity
0.32	GO:0003676	nucleic acid binding

0.50	GO:0016604	nuclear body
0.48	GO:0015629	actin cytoskeleton
0.48	GO:0009986	cell surface
0.41	GO:0005886	plasma membrane
0.37	GO:0005576	extracellular region
0.35	GO:0019898	extrinsic component of membrane
0.34	GO:0031410	cytoplasmic vesicle
0.32	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.61

GO:0004252

tr|T1EFB5|T1EFB5_HELRO
Uncharacterized protein
Search

HYOU1

0.90	Hypoxia up-regulated protein 1

0.55	GO:1903382	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
0.55	GO:1903297	regulation of hypoxia-induced intrinsic apoptotic signaling pathway
0.54	GO:1900038	negative regulation of cellular response to hypoxia
0.53	GO:0002931	response to ischemia
0.52	GO:0071456	cellular response to hypoxia
0.50	GO:0034976	response to endoplasmic reticulum stress
0.49	GO:0006888	ER to Golgi vesicle-mediated transport
0.35	GO:0060964	regulation of gene silencing by miRNA
0.34	GO:0034620	cellular response to unfolded protein
0.33	GO:0006898	receptor-mediated endocytosis

0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0051087	chaperone binding
0.35	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.32	GO:0003677	DNA binding

0.54	GO:0034663	endoplasmic reticulum chaperone complex
0.41	GO:0005788	endoplasmic reticulum lumen
0.36	GO:0005790	smooth endoplasmic reticulum
0.35	GO:0005925	focal adhesion
0.35	GO:0070062	extracellular exosome
0.35	GO:0071682	endocytic vesicle lumen
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.35

GO:0032440

tr|T1EFB6|T1EFB6_HELRO
Uncharacterized protein
Search

0.76	GO:0008203	cholesterol metabolic process
0.67	GO:0016042	lipid catabolic process
0.48	GO:0046339	diacylglycerol metabolic process
0.45	GO:0006641	triglyceride metabolic process
0.45	GO:0001676	long-chain fatty acid metabolic process
0.43	GO:0072329	monocarboxylic acid catabolic process
0.33	GO:0006468	protein phosphorylation
0.32	GO:1990884	RNA acetylation
0.32	GO:0042274	ribosomal small subunit biogenesis
0.32	GO:0000154	rRNA modification

0.69	GO:0016298	lipase activity
0.44	GO:0019901	protein kinase binding
0.42	GO:0052689	carboxylic ester hydrolase activity
0.41	GO:0017171	serine hydrolase activity
0.33	GO:0000829	inositol heptakisphosphate kinase activity
0.32	GO:0046872	metal ion binding
0.32	GO:0008080	N-acetyltransferase activity
0.32	GO:0003677	DNA binding
0.31	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding

0.46	GO:0005811	lipid droplet
0.42	GO:0005829	cytosol
0.35	GO:0005901	caveola
0.32	GO:0005634	nucleus
0.32	GO:0031974	membrane-enclosed lumen
0.31	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

0.69	EC:3.1.1	GO:0016298
0.42	KEGG:R00630	GO:0052689

tr|T1EFB7|T1EFB7_HELRO
Uncharacterized protein
Search

0.46	GO:0045415	negative regulation of interleukin-8 biosynthetic process
0.45	GO:0010225	response to UV-C
0.44	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.44	GO:0042345	regulation of NF-kappaB import into nucleus
0.44	GO:0030330	DNA damage response, signal transduction by p53 class mediator
0.44	GO:0000060	protein import into nucleus, translocation
0.44	GO:0046426	negative regulation of JAK-STAT cascade
0.44	GO:0007249	I-kappaB kinase/NF-kappaB signaling
0.43	GO:0051101	regulation of DNA binding
0.43	GO:0016043	cellular component organization

0.41	GO:0003723	RNA binding
0.41	GO:0004842	ubiquitin-protein transferase activity
0.41	GO:0008134	transcription factor binding
0.41	GO:0004003	ATP-dependent DNA helicase activity
0.39	GO:0003756	protein disulfide isomerase activity
0.39	GO:0017076	purine nucleotide binding
0.39	GO:0097367	carbohydrate derivative binding
0.39	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0008144	drug binding
0.38	GO:0003677	DNA binding

0.46	GO:0032996	Bcl3-Bcl10 complex
0.46	GO:0033257	Bcl3/NF-kappaB2 complex
0.43	GO:0030496	midbody
0.42	GO:0043231	intracellular membrane-bounded organelle
0.40	GO:0005829	cytosol
0.40	GO:0012505	endomembrane system
0.39	GO:0070013	intracellular organelle lumen
0.39	GO:0044446	intracellular organelle part
0.37	GO:0005886	plasma membrane
0.36	GO:0032126	eisosome

0.39	EC:5.3.4.1	GO:0003756
0.41	KEGG:R03876	GO:0004842

tr|T1EFB8|T1EFB8_HELRO
Uncharacterized protein
Search

0.53	GO:0055114	oxidation-reduction process
0.34	GO:0046580	negative regulation of Ras protein signal transduction
0.33	GO:0043547	positive regulation of GTPase activity
0.33	GO:0015992	proton transport
0.33	GO:0032259	methylation
0.32	GO:0007165	signal transduction
0.32	GO:0070988	demethylation

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.66	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.34	GO:0008746	NAD(P)+ transhydrogenase activity
0.33	GO:0005096	GTPase activator activity
0.33	GO:0010181	FMN binding
0.33	GO:0008168	methyltransferase activity
0.32	GO:0032451	demethylase activity

0.34	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0031090	organelle membrane
0.30	GO:0031224	intrinsic component of membrane

0.68	EC:1.14	GO:0016705
0.34	KEGG:R00112	GO:0008746

tr|T1EFB9|T1EFB9_HELRO
Uncharacterized protein
Search

tr|T1EFC0|T1EFC0_HELRO
Uncharacterized protein
Search

PDSS2

0.93	Mutant decaprenyl diphosphate synthase subunit 2

0.71	GO:0008299	isoprenoid biosynthetic process
0.55	GO:0051290	protein heterotetramerization
0.52	GO:0050878	regulation of body fluid levels
0.50	GO:0006744	ubiquinone biosynthetic process

0.57	GO:0000010	trans-hexaprenyltranstransferase activity
0.56	GO:0050347	trans-octaprenyltranstransferase activity
0.49	GO:0046982	protein heterodimerization activity
0.38	GO:0036422	heptaprenyl diphosphate synthase activity

0.47	GO:1990234	transferase complex
0.47	GO:0005829	cytosol
0.43	GO:0005739	mitochondrion
0.33	GO:0070013	intracellular organelle lumen
0.32	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

0.56	EC:2.5.1.84 EC:2.5.1.85	GO:0050347
0.57	KEGG:R05612	GO:0000010

tr|T1EFC1|T1EFC1_HELRO
Acetyltransferase component of pyruvate dehydrogenase complex
Search

DLAT

0.52	Acetyltransferase component of pyruvate dehydrogenase complex

0.68	GO:0006090	pyruvate metabolic process
0.48	GO:0006085	acetyl-CoA biosynthetic process
0.47	GO:0050908	detection of light stimulus involved in visual perception
0.37	GO:0055114	oxidation-reduction process
0.33	GO:0006006	glucose metabolic process
0.33	GO:0006101	citrate metabolic process
0.32	GO:0006091	generation of precursor metabolites and energy

0.80	GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity
0.49	GO:0004738	pyruvate dehydrogenase activity
0.41	GO:0042802	identical protein binding
0.40	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

0.79	GO:0045254	pyruvate dehydrogenase complex
0.74	GO:0005759	mitochondrial matrix
0.43	GO:0043209	myelin sheath

0.80

EC:2.3.1.12

GO:0004742

tr|T1EFC2|T1EFC2_HELRO
Uncharacterized protein
Search

ETFDH

0.50	Electron transfer flavoprotein ubiquinone oxidoreductase

0.59	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
0.54	GO:0022904	respiratory electron transport chain
0.53	GO:0006979	response to oxidative stress
0.35	GO:0045454	cell redox homeostasis

0.66	GO:0048039	ubiquinone binding
0.64	GO:0016649	oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
0.55	GO:0043783	oxidoreductase activity, oxidizing metal ions with flavin as acceptor
0.52	GO:0051539	4 iron, 4 sulfur cluster binding
0.49	GO:0009055	electron transfer activity
0.37	GO:0050660	flavin adenine dinucleotide binding
0.37	GO:0004148	dihydrolipoyl dehydrogenase activity
0.36	GO:0046872	metal ion binding

0.60	GO:0031305	integral component of mitochondrial inner membrane
0.57	GO:0045251	electron transfer flavoprotein complex
0.49	GO:0005759	mitochondrial matrix
0.49	GO:0098798	mitochondrial protein complex

0.64

EC:1.5.5

GO:0016649

tr|T1EFC3|T1EFC3_HELRO
Uncharacterized protein
Search

ACE

0.57	Angiotensin-converting enzyme

0.61	GO:0006508	proteolysis
0.54	GO:0071838	cell proliferation in bone marrow
0.54	GO:1903597	negative regulation of gap junction assembly
0.54	GO:2000170	positive regulation of peptidyl-cysteine S-nitrosylation
0.53	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation
0.53	GO:1902033	regulation of hematopoietic stem cell proliferation
0.52	GO:0003084	positive regulation of systemic arterial blood pressure
0.51	GO:0002446	neutrophil mediated immunity
0.50	GO:0061098	positive regulation of protein tyrosine kinase activity
0.50	GO:0060047	heart contraction

0.84	GO:0008241	peptidyl-dipeptidase activity
0.72	GO:0004180	carboxypeptidase activity
0.67	GO:0008237	metallopeptidase activity
0.54	GO:0046872	metal ion binding
0.41	GO:0031711	bradykinin receptor binding
0.39	GO:0031434	mitogen-activated protein kinase kinase binding
0.39	GO:0008240	tripeptidyl-peptidase activity
0.39	GO:0051019	mitogen-activated protein kinase binding
0.39	GO:0031404	chloride ion binding
0.37	GO:0016805	dipeptidase activity

0.40	GO:0005886	plasma membrane
0.38	GO:0005615	extracellular space
0.38	GO:1903561	extracellular vesicle
0.38	GO:0005764	lysosome
0.37	GO:0009986	cell surface
0.37	GO:0005768	endosome
0.37	GO:0098552	side of membrane
0.35	GO:0097225	sperm midpiece
0.35	GO:0045178	basal part of cell
0.34	GO:0005903	brush border

0.84

EC:3.4.15

GO:0008241

tr|T1EFC4|T1EFC4_HELRO
Uncharacterized protein
Search

XPO6

0.94	Exportin-6-A

0.66	GO:0006886	intracellular protein transport
0.55	GO:0006611	protein export from nucleus

0.76	GO:0008536	Ran GTPase binding
0.48	GO:0008565	protein transporter activity

0.60	GO:0005634	nucleus
0.47	GO:0005829	cytosol
0.47	GO:0031974	membrane-enclosed lumen
0.43	GO:0043232	intracellular non-membrane-bounded organelle
0.42	GO:0044446	intracellular organelle part
0.42	GO:0005886	plasma membrane

tr|T1EFC5|T1EFC5_HELRO
Uncharacterized protein
Search

0.74	Alpha-N-acetylgalactosaminidase

0.60	GO:0005975	carbohydrate metabolic process
0.43	GO:0016139	glycoside catabolic process
0.42	GO:0019377	glycolipid catabolic process
0.42	GO:0006677	glycosylceramide metabolic process
0.41	GO:0046514	ceramide catabolic process
0.33	GO:0048870	cell motility
0.33	GO:0048034	heme O biosynthetic process

0.66	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.35	GO:0042803	protein homodimerization activity
0.33	GO:0008495	protoheme IX farnesyltransferase activity
0.33	GO:0016875	ligase activity, forming carbon-oxygen bonds
0.33	GO:0140101	catalytic activity, acting on a tRNA

0.34	GO:0005737	cytoplasm
0.34	GO:0031514	motile cilium
0.32	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016020	membrane

0.66

GO:0004553

tr|T1EFC6|T1EFC6_HELRO
Uncharacterized protein
Search

0.41	Synaptic vesicle-associated GTP-binding protein (Fragment)

0.43	GO:0048790	maintenance of presynaptic active zone structure
0.43	GO:0048789	cytoskeletal matrix organization at active zone
0.41	GO:0050804	modulation of chemical synaptic transmission
0.41	GO:0043051	regulation of pharyngeal pumping
0.40	GO:1905488	positive regulation of anterior/posterior axon guidance
0.40	GO:0007271	synaptic transmission, cholinergic
0.40	GO:0007617	mating behavior
0.40	GO:0007419	ventral cord development
0.39	GO:0018125	peptidyl-cysteine methylation
0.39	GO:0016192	vesicle-mediated transport

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0031489	myosin V binding
0.38	GO:0030742	GTP-dependent protein binding
0.34	GO:0004767	sphingomyelin phosphodiesterase activity
0.34	GO:0008168	methyltransferase activity
0.33	GO:0004871	signal transducer activity

0.45	GO:0008021	synaptic vesicle
0.41	GO:0048786	presynaptic active zone
0.38	GO:0043005	neuron projection
0.37	GO:0030141	secretory granule
0.36	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0005881	cytoplasmic microtubule
0.34	GO:1905360	GTPase complex
0.34	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.34	GO:0030054	cell junction
0.33	GO:0098797	plasma membrane protein complex

0.34	EC:3.1.4.12	GO:0004767
0.34	KEGG:R02541	GO:0004767

tr|T1EFC7|T1EFC7_HELRO
Uncharacterized protein
Search

0.44	Signal recognition particle receptor subunit beta

0.77	GO:0007264	small GTPase mediated signal transduction
0.58	GO:1902766	skeletal muscle satellite cell migration
0.56	GO:0090505	epiboly involved in wound healing
0.46	GO:0061640	cytoskeleton-dependent cytokinesis
0.44	GO:0061154	endothelial tube morphogenesis
0.43	GO:1903047	mitotic cell cycle process
0.43	GO:0008333	endosome to lysosome transport
0.43	GO:0071479	cellular response to ionizing radiation
0.43	GO:0070301	cellular response to hydrogen peroxide
0.43	GO:0010595	positive regulation of endothelial cell migration

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.43	GO:0019003	GDP binding
0.37	GO:0032794	GTPase activating protein binding
0.36	GO:0019900	kinase binding

0.46	GO:0097610	cell surface furrow
0.45	GO:0005622	intracellular
0.45	GO:0032155	cell division site part
0.40	GO:0031982	vesicle
0.40	GO:0098805	whole membrane
0.39	GO:0098588	bounding membrane of organelle
0.39	GO:0012505	endomembrane system
0.38	GO:0071944	cell periphery
0.38	GO:0120025	plasma membrane bounded cell projection
0.37	GO:0032421	stereocilium bundle

tr|T1EFC8|T1EFC8_HELRO
Uncharacterized protein
Search

0.91	Serine/threonine-protein phosphatase 4 regulatory subunit 3-B

0.73	GO:0045722	positive regulation of gluconeogenesis
0.60	GO:0006470	protein dephosphorylation
0.46	GO:0006402	mRNA catabolic process
0.44	GO:0019216	regulation of lipid metabolic process
0.42	GO:0006396	RNA processing
0.38	GO:0046907	intracellular transport

0.48	GO:0004654	polyribonucleotide nucleotidyltransferase activity
0.41	GO:0003723	RNA binding
0.37	GO:0005515	protein binding

0.70	GO:0030289	protein phosphatase 4 complex
0.67	GO:0005654	nucleoplasm
0.65	GO:0005813	centrosome
0.44	GO:0005737	cytoplasm
0.40	GO:0036128	CatSper complex

0.48

EC:2.7.7.8

GO:0004654

tr|T1EFC9|T1EFC9_HELRO
Uncharacterized protein
Search

SQD

0.71	RNA-binding protein musashi

0.48	GO:0008069	dorsal/ventral axis specification, ovarian follicular epithelium
0.48	GO:0030720	oocyte localization involved in germarium-derived egg chamber formation
0.47	GO:0045451	pole plasm oskar mRNA localization
0.47	GO:0016325	oocyte microtubule cytoskeleton organization
0.47	GO:0033119	negative regulation of RNA splicing
0.46	GO:0007297	ovarian follicle cell migration
0.42	GO:0048576	positive regulation of short-day photoperiodism, flowering
0.42	GO:0048578	positive regulation of long-day photoperiodism, flowering
0.40	GO:0006378	mRNA polyadenylation
0.35	GO:0000381	regulation of alternative mRNA splicing, via spliceosome

0.59	GO:0003723	RNA binding
0.33	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.33	GO:0004523	RNA-DNA hybrid ribonuclease activity
0.32	GO:0008168	methyltransferase activity
0.32	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.32	GO:0005509	calcium ion binding
0.32	GO:0003677	DNA binding
0.32	GO:0004672	protein kinase activity
0.31	GO:0030554	adenyl nucleotide binding
0.31	GO:0097367	carbohydrate derivative binding

0.48	GO:0035062	omega speckle
0.47	GO:0005703	polytene chromosome puff
0.42	GO:0000785	chromatin
0.40	GO:0019013	viral nucleocapsid
0.38	GO:0030529	intracellular ribonucleoprotein complex
0.37	GO:0005829	cytosol
0.34	GO:0005852	eukaryotic translation initiation factor 3 complex
0.34	GO:0005730	nucleolus
0.33	GO:1902494	catalytic complex
0.32	GO:0005856	cytoskeleton

0.33

GO:0036459

tr|T1EFD0|T1EFD0_HELRO
Uncharacterized protein
Search

0.58	Jade family PHD finger 1

0.43	GO:0048666	neuron development
0.42	GO:0060395	SMAD protein signal transduction
0.42	GO:0051865	protein autoubiquitination
0.42	GO:0048588	developmental cell growth
0.42	GO:0060560	developmental growth involved in morphogenesis
0.41	GO:0000209	protein polyubiquitination
0.41	GO:0050769	positive regulation of neurogenesis
0.41	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.40	GO:0120036	plasma membrane bounded cell projection organization
0.39	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway

0.54	GO:0046872	metal ion binding
0.40	GO:0061630	ubiquitin protein ligase activity
0.36	GO:0018024	histone-lysine N-methyltransferase activity
0.33	GO:0005515	protein binding
0.32	GO:0003676	nucleic acid binding

0.39	GO:0005654	nucleoplasm
0.34	GO:0031248	protein acetyltransferase complex
0.30	GO:0016020	membrane

0.36

GO:0018024

tr|T1EFD1|T1EFD1_HELRO
Uncharacterized protein
Search

tr|T1EFD2|T1EFD2_HELRO
Uncharacterized protein
Search

NSUN4

0.58	5-methylcytosine rRNA methyltransferase NSUN4

0.63	GO:0032259	methylation
0.53	GO:0070131	positive regulation of mitochondrial translation
0.51	GO:0006364	rRNA processing
0.49	GO:0042256	mature ribosome assembly
0.48	GO:0009451	RNA modification
0.40	GO:0044260	cellular macromolecule metabolic process
0.36	GO:2001141	regulation of RNA biosynthetic process
0.32	GO:0008033	tRNA processing
0.32	GO:0050482	arachidonic acid secretion
0.32	GO:0016042	lipid catabolic process

0.63	GO:0008168	methyltransferase activity
0.59	GO:0003723	RNA binding
0.41	GO:0140102	catalytic activity, acting on a rRNA
0.33	GO:0005515	protein binding
0.32	GO:0140101	catalytic activity, acting on a tRNA
0.32	GO:0004623	phospholipase A2 activity
0.32	GO:0005509	calcium ion binding

0.53	GO:0005762	mitochondrial large ribosomal subunit
0.32	GO:0005576	extracellular region

0.63

GO:0008168

tr|T1EFD3|T1EFD3_HELRO
Uncharacterized protein
Search

SLC4A1AP

0.66	Kanadaptin

0.51	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.38	GO:0016579	protein deubiquitination
0.38	GO:0006511	ubiquitin-dependent protein catabolic process

0.55	GO:0003723	RNA binding
0.51	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters
0.38	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.34	GO:0008080	N-acetyltransferase activity

0.38	GO:0005654	nucleoplasm
0.35	GO:0005886	plasma membrane

0.51

EC:3.1.26

GO:0016891

tr|T1EFD4|T1EFD4_HELRO
Uncharacterized protein
Search

STX18

0.90	Cell growth-inhibiting gene 9 protein

0.67	GO:0006886	intracellular protein transport
0.67	GO:0061025	membrane fusion
0.52	GO:1902953	positive regulation of ER to Golgi vesicle-mediated transport
0.51	GO:1903358	regulation of Golgi organization
0.51	GO:0090158	endoplasmic reticulum membrane organization
0.49	GO:1902117	positive regulation of organelle assembly
0.46	GO:0016192	vesicle-mediated transport

0.79	GO:0005484	SNAP receptor activity
0.47	GO:0019904	protein domain specific binding

0.47	GO:0005783	endoplasmic reticulum
0.46	GO:0031201	SNARE complex
0.38	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.38	GO:0000139	Golgi membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1EFD5|T1EFD5_HELRO
Uncharacterized protein
Search

PDK1

0.74	Pyruvate dehydrogenase kinase

0.58	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway
0.57	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
0.57	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
0.56	GO:0016310	phosphorylation
0.54	GO:0010906	regulation of glucose metabolic process
0.52	GO:0008283	cell proliferation
0.44	GO:0036211	protein modification process
0.42	GO:0044267	cellular protein metabolic process
0.37	GO:0006006	glucose metabolic process
0.34	GO:0007166	cell surface receptor signaling pathway

0.58	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity
0.35	GO:0005515	protein binding
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0044877	macromolecular complex binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0004674	protein serine/threonine kinase activity

0.54	GO:0005967	mitochondrial pyruvate dehydrogenase complex
0.49	GO:0005730	nucleolus
0.33	GO:0005886	plasma membrane

0.58

EC:2.7.11.2

GO:0004740

tr|T1EFD6|T1EFD6_HELRO
Uncharacterized protein
Search

CPEB2

0.74	Cytoplasmic polyadenylation element binding protein 3

0.69	GO:0006417	regulation of translation
0.51	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
0.50	GO:0050779	RNA destabilization
0.50	GO:0071230	cellular response to amino acid stimulus
0.49	GO:0043488	regulation of mRNA stability
0.48	GO:0034249	negative regulation of cellular amide metabolic process
0.47	GO:0000122	negative regulation of transcription by RNA polymerase II
0.46	GO:0032269	negative regulation of cellular protein metabolic process
0.42	GO:0043043	peptide biosynthetic process
0.40	GO:0044267	cellular protein metabolic process

0.80	GO:0003730	mRNA 3'-UTR binding
0.79	GO:0045182	translation regulator activity
0.45	GO:0008135	translation factor activity, RNA binding
0.41	GO:0043022	ribosome binding
0.38	GO:0035613	RNA stem-loop binding
0.38	GO:0017091	AU-rich element binding
0.34	GO:0005515	protein binding

0.49	GO:0043005	neuron projection
0.48	GO:0030014	CCR4-NOT complex
0.45	GO:1990124	messenger ribonucleoprotein complex
0.43	GO:0005634	nucleus
0.42	GO:0045202	synapse
0.38	GO:0036477	somatodendritic compartment
0.38	GO:0120038	plasma membrane bounded cell projection part
0.38	GO:0005737	cytoplasm
0.35	GO:0098590	plasma membrane region
0.35	GO:0030054	cell junction

tr|T1EFD7|T1EFD7_HELRO
Uncharacterized protein
Search

0.63	GO:0006468	protein phosphorylation
0.54	GO:0003016	respiratory system process
0.53	GO:0048286	lung alveolus development
0.53	GO:0060425	lung morphogenesis
0.52	GO:0035264	multicellular organism growth
0.49	GO:0043408	regulation of MAPK cascade
0.49	GO:0043066	negative regulation of apoptotic process
0.48	GO:0005977	glycogen metabolic process
0.41	GO:0010468	regulation of gene expression

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding

0.46	GO:0005654	nucleoplasm
0.45	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

tr|T1EFD8|T1EFD8_HELRO
Methylenetetrahydrofolate reductase
Search

MTHFR

0.49	Methylenetetrahydrofolate reductase

0.75	GO:0035999	tetrahydrofolate interconversion
0.72	GO:0006555	methionine metabolic process
0.56	GO:0070829	heterochromatin maintenance
0.54	GO:0031060	regulation of histone methylation
0.53	GO:0050667	homocysteine metabolic process
0.52	GO:0055114	oxidation-reduction process
0.39	GO:0033274	response to vitamin B2
0.38	GO:0051593	response to folic acid
0.37	GO:0070555	response to interleukin-1
0.37	GO:0043200	response to amino acid

0.79	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity
0.49	GO:0032403	protein complex binding
0.49	GO:0072341	modified amino acid binding
0.46	GO:0050660	flavin adenine dinucleotide binding
0.35	GO:0050661	NADP binding

0.43	GO:0005829	cytosol
0.36	GO:0045202	synapse

0.79	EC:1.5.1.20	GO:0004489
0.79	KEGG:R01224 KEGG:R07168	GO:0004489

tr|T1EFD9|T1EFD9_HELRO
Uncharacterized protein
Search

GPS1

0.78	G protein pathway suppressor 1

0.84	GO:0000338	protein deneddylation
0.36	GO:0048140	male germ-line cyst encapsulation
0.36	GO:0048142	germarium-derived cystoblast division
0.36	GO:0036099	female germ-line stem cell population maintenance
0.35	GO:0050821	protein stabilization
0.35	GO:0034260	negative regulation of GTPase activity
0.34	GO:0007254	JNK cascade
0.34	GO:0000188	inactivation of MAPK activity
0.34	GO:0043687	post-translational protein modification
0.34	GO:0000715	nucleotide-excision repair, DNA damage recognition

0.35	GO:0005095	GTPase inhibitor activity
0.34	GO:0005515	protein binding
0.34	GO:0003677	DNA binding
0.33	GO:0009055	electron transfer activity
0.32	GO:0016787	hydrolase activity

0.81	GO:0008180	COP9 signalosome
0.35	GO:1905369	endopeptidase complex
0.33	GO:0005654	nucleoplasm
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016787

tr|T1EFE0|T1EFE0_HELRO
Uncharacterized protein
Search

0.39	GO:1903506	regulation of nucleic acid-templated transcription
0.39	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.39	GO:0010468	regulation of gene expression
0.36	GO:0070895	negative regulation of transposon integration
0.35	GO:0007050	cell cycle arrest
0.34	GO:0008285	negative regulation of cell proliferation
0.34	GO:1902680	positive regulation of RNA biosynthetic process
0.34	GO:1902679	negative regulation of RNA biosynthetic process
0.32	GO:0006351	transcription, DNA-templated
0.32	GO:0032259	methylation

0.51	GO:0003676	nucleic acid binding
0.38	GO:0046872	metal ion binding
0.35	GO:0001223	transcription coactivator binding
0.35	GO:0003700	DNA binding transcription factor activity
0.32	GO:0008168	methyltransferase activity

0.37	GO:0005634	nucleus
0.34	GO:0015630	microtubule cytoskeleton
0.34	GO:0005829	cytosol
0.33	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part

0.32

GO:0008168

tr|T1EFE1|T1EFE1_HELRO
Uncharacterized protein
Search

0.47	GO:0036211	protein modification process
0.45	GO:0048522	positive regulation of cellular process
0.45	GO:0023056	positive regulation of signaling
0.45	GO:0007219	Notch signaling pathway
0.45	GO:0048584	positive regulation of response to stimulus
0.45	GO:0044267	cellular protein metabolic process
0.44	GO:0008593	regulation of Notch signaling pathway
0.43	GO:0016348	imaginal disc-derived leg joint morphogenesis
0.42	GO:0016310	phosphorylation
0.41	GO:0035220	wing disc development

0.47	GO:0003677	DNA binding
0.46	GO:0140096	catalytic activity, acting on a protein
0.44	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.43	GO:0016301	kinase activity
0.42	GO:0016278	lysine N-methyltransferase activity
0.42	GO:0035591	signaling adaptor activity
0.42	GO:0005112	Notch binding
0.41	GO:0030554	adenyl nucleotide binding
0.41	GO:0003713	transcription coactivator activity
0.40	GO:0097367	carbohydrate derivative binding

0.53	GO:0005634	nucleus
0.42	GO:0070013	intracellular organelle lumen
0.42	GO:0034708	methyltransferase complex
0.39	GO:0097482	muscle cell postsynaptic specialization
0.39	GO:0044446	intracellular organelle part
0.39	GO:0016327	apicolateral plasma membrane
0.38	GO:0043195	terminal bouton
0.37	GO:0005912	adherens junction
0.35	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

0.44

GO:0016773

tr|T1EFE2|T1EFE2_HELRO
Uncharacterized protein
Search

COLGALT2

0.84	Cerebral endothelial cell adhesion molecule

0.38	GO:0007155	cell adhesion
0.35	GO:0006468	protein phosphorylation
0.33	GO:0055114	oxidation-reduction process

0.49	GO:0016740	transferase activity
0.35	GO:0140096	catalytic activity, acting on a protein
0.35	GO:0051213	dioxygenase activity
0.34	GO:0005515	protein binding
0.34	GO:0030554	adenyl nucleotide binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0008144	drug binding
0.31	GO:0016787	hydrolase activity

0.38	GO:0005788	endoplasmic reticulum lumen
0.35	GO:0005581	collagen trimer
0.30	GO:0031224	intrinsic component of membrane

0.49

GO:0016740

tr|T1EFE3|T1EFE3_HELRO
Uncharacterized protein
Search

tr|T1EFE4|T1EFE4_HELRO
Uncharacterized protein
Search

tr|T1EFE5|T1EFE5_HELRO
Uncharacterized protein
Search

RDX

0.91

Radixin

0.56	GO:1902965	regulation of protein localization to early endosome
0.55	GO:2000643	positive regulation of early endosome to late endosome transport
0.55	GO:1905668	positive regulation of protein localization to endosome
0.54	GO:0061028	establishment of endothelial barrier
0.51	GO:0008361	regulation of cell size
0.51	GO:1902115	regulation of organelle assembly
0.51	GO:1903364	positive regulation of cellular protein catabolic process
0.50	GO:0030334	regulation of cell migration
0.50	GO:0070489	T cell aggregation
0.49	GO:0022614	membrane to membrane docking

0.72	GO:0003779	actin binding
0.51	GO:0050839	cell adhesion molecule binding
0.47	GO:0019899	enzyme binding
0.44	GO:0003725	double-stranded RNA binding
0.43	GO:0019904	protein domain specific binding
0.43	GO:0005102	receptor binding
0.42	GO:0042803	protein homodimerization activity
0.35	GO:0051018	protein kinase A binding
0.33	GO:0005200	structural constituent of cytoskeleton

0.69	GO:0005856	cytoskeleton
0.53	GO:0005902	microvillus
0.52	GO:0030175	filopodium
0.52	GO:0016324	apical plasma membrane
0.51	GO:0005925	focal adhesion
0.50	GO:0043209	myelin sheath
0.48	GO:0071437	invadopodium
0.47	GO:0031143	pseudopodium
0.47	GO:0001931	uropod
0.45	GO:0032420	stereocilium

tr|T1EFE6|T1EFE6_HELRO
Uncharacterized protein
Search

PAPSS1

0.69	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase

0.77	GO:0000103	sulfate assimilation
0.57	GO:0016310	phosphorylation
0.48	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
0.34	GO:0006011	UDP-glucose metabolic process

0.80	GO:0004020	adenylylsulfate kinase activity
0.79	GO:0004781	sulfate adenylyltransferase (ATP) activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0042803	protein homodimerization activity
0.34	GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity
0.33	GO:0008270	zinc ion binding

0.33

GO:0005634

nucleus

0.80	EC:2.7.1.25	GO:0004020
0.34	KEGG:R00289	GO:0003983

tr|T1EFE7|T1EFE7_HELRO
Uncharacterized protein
Search

SAMHD1

0.92	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

0.72	GO:0006203	dGTP catabolic process
0.72	GO:0046061	dATP catabolic process
0.65	GO:0051289	protein homotetramerization
0.64	GO:0051607	defense response to virus
0.60	GO:0045088	regulation of innate immune response
0.55	GO:0090501	RNA phosphodiester bond hydrolysis
0.42	GO:0045087	innate immune response
0.38	GO:0044830	modulation by host of viral RNA genome replication
0.37	GO:1903901	negative regulation of viral life cycle
0.36	GO:0019221	cytokine-mediated signaling pathway

0.73	GO:0032567	dGTP binding
0.72	GO:0008832	dGTPase activity
0.57	GO:0042802	identical protein binding
0.55	GO:0004540	ribonuclease activity
0.52	GO:0008270	zinc ion binding
0.50	GO:0003723	RNA binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.55	GO:0005654	nucleoplasm
0.46	GO:0005886	plasma membrane
0.35	GO:0005667	transcription factor complex
0.30	GO:0016021	integral component of membrane

0.72	EC:3.1.5.1	GO:0008832
0.72	KEGG:R01856	GO:0008832

tr|T1EFE8|T1EFE8_HELRO
Uncharacterized protein
Search

0.42	GO:0006972	hyperosmotic response
0.41	GO:0042274	ribosomal small subunit biogenesis
0.36	GO:0045454	cell redox homeostasis
0.34	GO:0022008	neurogenesis
0.34	GO:0006413	translational initiation
0.34	GO:0055114	oxidation-reduction process

0.59	GO:0003723	RNA binding
0.37	GO:0004148	dihydrolipoyl dehydrogenase activity
0.35	GO:0050660	flavin adenine dinucleotide binding
0.35	GO:0046872	metal ion binding

0.43	GO:0097078	FAL1-SGD1 complex
0.41	GO:0005730	nucleolus
0.30	GO:0031224	intrinsic component of membrane

0.37

EC:1.8.1.4

GO:0004148

tr|T1EFE9|T1EFE9_HELRO
Uncharacterized protein
Search

CASP7

0.69	Caspase 7, apoptosis-related cysteine peptidase

0.61	GO:0006508	proteolysis
0.52	GO:0006915	apoptotic process
0.44	GO:0048699	generation of neurons
0.43	GO:0071236	cellular response to antibiotic
0.42	GO:0071300	cellular response to retinoic acid
0.42	GO:0061387	regulation of extent of cell growth
0.42	GO:0043065	positive regulation of apoptotic process
0.41	GO:0060284	regulation of cell development
0.41	GO:0048638	regulation of developmental growth
0.41	GO:2000026	regulation of multicellular organismal development

0.75	GO:0004197	cysteine-type endopeptidase activity
0.42	GO:1990525	BIR domain binding

0.36	GO:0005737	cytoplasm
0.34	GO:0043227	membrane-bounded organelle
0.34	GO:0043229	intracellular organelle
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.75

GO:0004197

tr|T1EFF0|T1EFF0_HELRO
Uncharacterized protein
Search

CASP7

0.88	Caspase 3, apoptosis-related cysteine peptidase b

0.61	GO:0006508	proteolysis
0.57	GO:0097194	execution phase of apoptosis
0.55	GO:0051402	neuron apoptotic process
0.52	GO:0009411	response to UV
0.51	GO:0007507	heart development
0.48	GO:0051604	protein maturation
0.43	GO:0072734	cellular response to staurosporine
0.43	GO:0043065	positive regulation of apoptotic process
0.43	GO:0048696	regulation of collateral sprouting in absence of injury
0.43	GO:0071236	cellular response to antibiotic

0.75	GO:0004197	cysteine-type endopeptidase activity
0.47	GO:0070001	aspartic-type peptidase activity
0.39	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
0.35	GO:0005515	protein binding

0.39	GO:0005829	cytosol
0.37	GO:0005634	nucleus
0.34	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0043233	organelle lumen
0.33	GO:0031966	mitochondrial membrane

0.75

GO:0004197

tr|T1EFF1|T1EFF1_HELRO
Uncharacterized protein
Search

0.67	Neurohemerythrin

0.37

GO:0015671

oxygen transport

0.62	GO:0005506	iron ion binding
0.37	GO:0005344	oxygen carrier activity

tr|T1EFF2|T1EFF2_HELRO
Uncharacterized protein
Search

0.50	GO:0006366	transcription by RNA polymerase II
0.40	GO:1903506	regulation of nucleic acid-templated transcription
0.40	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.40	GO:0010468	regulation of gene expression
0.35	GO:0042035	regulation of cytokine biosynthetic process
0.34	GO:1902680	positive regulation of RNA biosynthetic process
0.33	GO:0040034	regulation of development, heterochronic
0.32	GO:1902679	negative regulation of RNA biosynthetic process
0.32	GO:0007275	multicellular organism development
0.32	GO:0007165	signal transduction

0.51	GO:0003676	nucleic acid binding
0.40	GO:0046872	metal ion binding
0.36	GO:0003700	DNA binding transcription factor activity

0.52	GO:0005665	DNA-directed RNA polymerase II, core complex
0.30	GO:0031224	intrinsic component of membrane

tr|T1EFF3|T1EFF3_HELRO
Uncharacterized protein
Search

0.73

GO:0043304

regulation of mast cell degranulation

0.40

GO:0008270

zinc ion binding

0.44	GO:0005737	cytoplasm
0.39	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

tr|T1EFF4|T1EFF4_HELRO
Uncharacterized protein
Search

CWF19L1

0.97	CWF19 like 1, cell cycle control (S. pombe)

0.42	GO:0006030	chitin metabolic process
0.42	GO:0006468	protein phosphorylation
0.41	GO:0007165	signal transduction
0.38	GO:0043043	peptide biosynthetic process
0.37	GO:0010469	regulation of receptor activity
0.37	GO:0010467	gene expression
0.36	GO:0009059	macromolecule biosynthetic process
0.35	GO:0005975	carbohydrate metabolic process

0.50	GO:0017049	GTP-Rho binding
0.44	GO:0003723	RNA binding
0.44	GO:0004674	protein serine/threonine kinase activity
0.42	GO:0008061	chitin binding
0.41	GO:0005509	calcium ion binding
0.39	GO:0003735	structural constituent of ribosome
0.39	GO:0032559	adenyl ribonucleotide binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0008270	zinc ion binding
0.38	GO:0005179	hormone activity

0.41	GO:0005576	extracellular region
0.38	GO:0005840	ribosome
0.30	GO:0016020	membrane

0.44

GO:0004674

tr|T1EFF5|T1EFF5_HELRO
Uncharacterized protein
Search

0.78	Tropomodulin

0.85	GO:0051694	pointed-end actin filament capping
0.37	GO:0030239	myofibril assembly
0.36	GO:0007015	actin filament organization
0.33	GO:0006936	muscle contraction

0.85	GO:0005523	tropomyosin binding
0.40	GO:0003779	actin binding
0.33	GO:0010181	FMN binding

0.46	GO:0045169	fusome
0.41	GO:0005938	cell cortex
0.36	GO:0030016	myofibril
0.35	GO:0005856	cytoskeleton
0.30	GO:0016020	membrane

tr|T1EFF6|T1EFF6_HELRO
Uncharacterized protein
Search

tr|T1EFF7|T1EFF7_HELRO
Uncharacterized protein
Search

tr|T1EFF8|T1EFF8_HELRO
Uncharacterized protein
Search

CTTN

0.63	Hematopoietic cell-specific Lyn substrate 1

0.83	GO:0030041	actin filament polymerization
0.58	GO:0097062	dendritic spine maintenance
0.58	GO:0006930	substrate-dependent cell migration, cell extension
0.55	GO:1903146	regulation of autophagy of mitochondrion
0.55	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
0.55	GO:0045987	positive regulation of smooth muscle contraction
0.52	GO:0030833	regulation of actin filament polymerization
0.51	GO:0032273	positive regulation of protein polymerization
0.51	GO:1902905	positive regulation of supramolecular fiber organization
0.51	GO:0051495	positive regulation of cytoskeleton organization

0.56	GO:0005522	profilin binding
0.52	GO:0045296	cadherin binding
0.38	GO:0003779	actin binding
0.38	GO:0032403	protein complex binding
0.37	GO:0001085	RNA polymerase II transcription factor binding
0.37	GO:0017124	SH3 domain binding
0.37	GO:0019901	protein kinase binding
0.36	GO:0070064	proline-rich region binding
0.32	GO:0016491	oxidoreductase activity

0.56	GO:0002102	podosome
0.55	GO:1990023	mitotic spindle midzone
0.54	GO:0001726	ruffle
0.54	GO:0030027	lamellipodium
0.53	GO:0005884	actin filament
0.52	GO:0030863	cortical cytoskeleton
0.52	GO:0008076	voltage-gated potassium channel complex
0.47	GO:0005794	Golgi apparatus
0.47	GO:0005829	cytosol
0.40	GO:0043197	dendritic spine

0.32

GO:0016491

tr|T1EFF9|T1EFF9_HELRO
Uncharacterized protein
Search

STT3B

0.72	Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit

0.74	GO:0006486	protein glycosylation
0.50	GO:0018196	peptidyl-asparagine modification
0.48	GO:0043687	post-translational protein modification
0.48	GO:0043686	co-translational protein modification
0.46	GO:0006516	glycoprotein catabolic process
0.45	GO:0006986	response to unfolded protein
0.45	GO:0030433	ubiquitin-dependent ERAD pathway
0.35	GO:0006520	cellular amino acid metabolic process
0.34	GO:0035335	peptidyl-tyrosine dephosphorylation
0.33	GO:0008299	isoprenoid biosynthetic process

0.83	GO:0004576	oligosaccharyl transferase activity
0.39	GO:0004067	asparaginase activity
0.34	GO:0004452	isopentenyl-diphosphate delta-isomerase activity
0.34	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.34	GO:0004725	protein tyrosine phosphatase activity
0.33	GO:0046872	metal ion binding
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.46	GO:0008250	oligosaccharyltransferase complex
0.33	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

0.83	EC:2.4.1	GO:0004576
0.34	KEGG:R01123	GO:0004452

tr|T1EFG0|T1EFG0_HELRO
Uncharacterized protein
Search

0.55	GO:0055085	transmembrane transport
0.35	GO:0015718	monocarboxylic acid transport

0.35

GO:0008028

monocarboxylic acid transmembrane transporter activity

0.30

GO:0016021

integral component of membrane

tr|T1EFG1|T1EFG1_HELRO
Uncharacterized protein
Search

0.19	SUPpressor

0.77

GO:0017148

negative regulation of translation

0.84	GO:0003730	mRNA 3'-UTR binding
0.63	GO:0005515	protein binding

0.49

GO:0005737

cytoplasm

tr|T1EFG2|T1EFG2_HELRO
U1 small nuclear ribonucleoprotein C
Search

SNRPC

0.74	U1 small nuclear ribonucleoprotein C

0.81	GO:0000395	mRNA 5'-splice site recognition
0.80	GO:0000387	spliceosomal snRNP assembly
0.41	GO:0000381	regulation of alternative mRNA splicing, via spliceosome

0.78	GO:0030619	U1 snRNA binding
0.69	GO:0003729	mRNA binding
0.63	GO:0008270	zinc ion binding
0.49	GO:0030627	pre-mRNA 5'-splice site binding
0.48	GO:0003727	single-stranded RNA binding
0.46	GO:0042803	protein homodimerization activity
0.38	GO:1990446	U1 snRNP binding
0.32	GO:0003677	DNA binding

0.81	GO:0005685	U1 snRNP
0.79	GO:0000243	commitment complex
0.77	GO:0071010	prespliceosome
0.58	GO:0019013	viral nucleocapsid
0.50	GO:0015030	Cajal body
0.30	GO:0016020	membrane

tr|T1EFG3|T1EFG3_HELRO
Uncharacterized protein
Search

0.49	RUN domain-containing protein 1

0.73	GO:0051049	regulation of transport
0.71	GO:0090630	activation of GTPase activity
0.69	GO:1990502	dense core granule maturation
0.69	GO:0090326	positive regulation of locomotion involved in locomotory behavior
0.69	GO:1901046	positive regulation of oviposition
0.68	GO:0061065	regulation of dauer larval development
0.63	GO:0033043	regulation of organelle organization
0.61	GO:0044057	regulation of system process
0.59	GO:0006886	intracellular protein transport
0.58	GO:0060341	regulation of cellular localization

0.79	GO:0017137	Rab GTPase binding
0.65	GO:0005096	GTPase activator activity

0.66	GO:0000138	Golgi trans cisterna
0.61	GO:0043025	neuronal cell body
0.61	GO:0030424	axon
0.60	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0031224	intrinsic component of membrane

tr|T1EFG4|T1EFG4_HELRO
Uncharacterized protein
Search

0.57	F-box/LRR-repeat protein 7

0.62	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
0.55	GO:0016567	protein ubiquitination

0.55	GO:0004842	ubiquitin-protein transferase activity
0.54	GO:0003924	GTPase activity
0.53	GO:0032550	purine ribonucleoside binding
0.52	GO:0019001	guanyl nucleotide binding
0.45	GO:0032555	purine ribonucleotide binding
0.45	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0016874	ligase activity
0.39	GO:0003723	RNA binding

0.61

GO:0019005

SCF ubiquitin ligase complex

0.44	EC:6	GO:0016874
0.55	KEGG:R03876	GO:0004842

tr|T1EFG5|T1EFG5_HELRO
Uncharacterized protein
Search

0.47	Collagen triple helix repeat (20 copies)

0.50	GO:0010951	negative regulation of endopeptidase activity
0.47	GO:0035987	endodermal cell differentiation
0.40	GO:0009405	pathogenesis
0.38	GO:0009612	response to mechanical stimulus
0.37	GO:0007155	cell adhesion
0.36	GO:0032963	collagen metabolic process
0.35	GO:0030198	extracellular matrix organization
0.35	GO:0044243	multicellular organismal catabolic process
0.35	GO:0006461	protein complex assembly
0.34	GO:0048207	vesicle targeting, rough ER to cis-Golgi

0.57	GO:0005201	extracellular matrix structural constituent
0.51	GO:0004867	serine-type endopeptidase inhibitor activity
0.44	GO:0042802	identical protein binding
0.36	GO:0042302	structural constituent of cuticle
0.35	GO:0051431	corticotropin-releasing hormone receptor 2 binding
0.34	GO:0005509	calcium ion binding
0.34	GO:0048407	platelet-derived growth factor binding
0.34	GO:0002020	protease binding
0.34	GO:0005179	hormone activity
0.33	GO:0004222	metalloendopeptidase activity

0.57	GO:0005581	collagen trimer
0.50	GO:0044420	extracellular matrix component
0.48	GO:0005578	proteinaceous extracellular matrix
0.39	GO:0019867	outer membrane
0.36	GO:0005615	extracellular space
0.35	GO:0099080	supramolecular complex
0.34	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
0.34	GO:0005788	endoplasmic reticulum lumen
0.34	GO:0031594	neuromuscular junction
0.34	GO:0031410	cytoplasmic vesicle

0.33

GO:0004222

tr|T1EFG6|T1EFG6_HELRO
Uncharacterized protein
Search

0.70	Transcription factor collier

0.70	GO:0007275	multicellular organism development
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.39	GO:0051254	positive regulation of RNA metabolic process
0.39	GO:0010557	positive regulation of macromolecule biosynthetic process
0.39	GO:0031328	positive regulation of cellular biosynthetic process
0.35	GO:0097065	anterior head development
0.34	GO:0035203	regulation of lamellocyte differentiation

0.67	GO:0046983	protein dimerization activity
0.58	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.54	GO:0046872	metal ion binding
0.39	GO:0001067	regulatory region nucleic acid binding
0.33	GO:0008134	transcription factor binding

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

tr|T1EFG7|T1EFG7_HELRO
Uncharacterized protein
Search

SLC12A8

0.67	Solute carrier family 12 member 8

0.55	GO:0055085	transmembrane transport
0.42	GO:0006821	chloride transport
0.41	GO:0060271	cilium assembly
0.41	GO:0071804	cellular potassium ion transport
0.34	GO:0006865	amino acid transport
0.33	GO:0006886	intracellular protein transport
0.33	GO:0016192	vesicle-mediated transport

0.44	GO:0015377	cation:chloride symporter activity
0.42	GO:0022820	potassium ion symporter activity
0.35	GO:0015171	amino acid transmembrane transporter activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.34	GO:0030117	membrane coat
0.30	GO:0016021	integral component of membrane

tr|T1EFG8|T1EFG8_HELRO
Uncharacterized protein
Search

tr|T1EFG9|T1EFG9_HELRO
Uncharacterized protein
Search

RFC1

0.71	Replication factor C subunit 1

0.66	GO:0006260	DNA replication
0.64	GO:0006281	DNA repair
0.37	GO:0000122	negative regulation of transcription by RNA polymerase II
0.36	GO:0045893	positive regulation of transcription, DNA-templated
0.35	GO:0042769	DNA damage response, detection of DNA damage
0.35	GO:0007004	telomere maintenance via telomerase
0.34	GO:0048813	dendrite morphogenesis
0.34	GO:0006351	transcription, DNA-templated
0.34	GO:0043085	positive regulation of catalytic activity
0.34	GO:0022402	cell cycle process

0.84	GO:0003689	DNA clamp loader activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0019904	protein domain specific binding
0.36	GO:0003690	double-stranded DNA binding
0.35	GO:0043565	sequence-specific DNA binding
0.34	GO:0008047	enzyme activator activity
0.33	GO:0003723	RNA binding

0.83	GO:0005663	DNA replication factor C complex
0.57	GO:0005634	nucleus
0.45	GO:0031974	membrane-enclosed lumen
0.37	GO:0070062	extracellular exosome
0.33	GO:0005737	cytoplasm

tr|T1EFH0|T1EFH0_HELRO
Polypeptide N-acetylgalactosaminyltransferase
Search

0.63	Polypeptide N-acetylgalactosaminyltransferase

0.72	GO:0006486	protein glycosylation
0.47	GO:0018210	peptidyl-threonine modification
0.39	GO:0061314	Notch signaling involved in heart development
0.38	GO:0007220	Notch receptor processing
0.38	GO:0009312	oligosaccharide biosynthetic process
0.38	GO:0008593	regulation of Notch signaling pathway
0.38	GO:0007368	determination of left/right symmetry
0.37	GO:0060271	cilium assembly
0.35	GO:0006413	translational initiation
0.34	GO:0018209	peptidyl-serine modification

0.68	GO:0030246	carbohydrate binding
0.64	GO:0016757	transferase activity, transferring glycosyl groups
0.47	GO:0005112	Notch binding
0.40	GO:0140096	catalytic activity, acting on a protein
0.35	GO:0003743	translation initiation factor activity
0.34	GO:0046872	metal ion binding
0.34	GO:0030983	mismatched DNA binding
0.33	GO:0022857	transmembrane transporter activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.71	GO:0000139	Golgi membrane
0.34	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.64

GO:0016757

tr|T1EFH1|T1EFH1_HELRO
Uncharacterized protein
Search

0.87	Cytoplasmic FMR1 interacting protein 2

0.74	GO:0048812	neuron projection morphogenesis
0.70	GO:0060269	centripetally migrating follicle cell migration
0.68	GO:0061564	axon development
0.68	GO:0048667	cell morphogenesis involved in neuron differentiation
0.66	GO:0033627	cell adhesion mediated by integrin
0.65	GO:0022416	chaeta development
0.65	GO:0051491	positive regulation of filopodium assembly
0.65	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway
0.64	GO:0048588	developmental cell growth
0.64	GO:0001745	compound eye morphogenesis

0.51	GO:0048365	Rac GTPase binding
0.49	GO:0032403	protein complex binding
0.42	GO:0070325	lipoprotein particle receptor binding
0.39	GO:0003779	actin binding
0.36	GO:0004672	protein kinase activity
0.35	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0003676	nucleic acid binding

0.71	GO:0031209	SCAR complex
0.61	GO:0045177	apical part of cell
0.59	GO:0048471	perinuclear region of cytoplasm
0.55	GO:0045202	synapse
0.49	GO:0030027	lamellipodium
0.47	GO:0043005	neuron projection
0.47	GO:0005845	mRNA cap binding complex
0.41	GO:0001726	ruffle
0.40	GO:0030054	cell junction
0.30	GO:0016020	membrane

tr|T1EFH2|T1EFH2_HELRO
Uncharacterized protein
Search

0.33	GO:0000147	actin cortical patch assembly
0.33	GO:0006897	endocytosis
0.32	GO:0006886	intracellular protein transport
0.32	GO:0055114	oxidation-reduction process

0.70	GO:0005509	calcium ion binding
0.34	GO:0005515	protein binding
0.33	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

0.33	GO:0030479	actin cortical patch
0.33	GO:0010008	endosome membrane
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0016620

tr|T1EFH3|T1EFH3_HELRO
Uncharacterized protein
Search

LARS2

0.81	Leucine--tRNA ligase, mitochondrial

0.78	GO:0006429	leucyl-tRNA aminoacylation
0.66	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity
0.46	GO:0032543	mitochondrial translation
0.38	GO:0000372	Group I intron splicing
0.37	GO:0006468	protein phosphorylation

0.79	GO:0004823	leucine-tRNA ligase activity
0.66	GO:0002161	aminoacyl-tRNA editing activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0004672	protein kinase activity
0.36	GO:0003729	mRNA binding

0.43	GO:0005739	mitochondrion
0.36	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part
0.33	GO:0009536	plastid
0.30	GO:0031224	intrinsic component of membrane

0.79	EC:6.1.1.4	GO:0004823
0.79	KEGG:R03657	GO:0004823

tr|T1EFH4|T1EFH4_HELRO
Uncharacterized protein
Search

tr|T1EFH5|T1EFH5_HELRO
Uncharacterized protein
Search

MRPL18

0.54	Mitochondrial ribosomal protein L18

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0035928	rRNA import into mitochondrion
0.53	GO:0009059	macromolecule biosynthetic process
0.33	GO:0043624	cellular protein complex disassembly

0.64	GO:0003735	structural constituent of ribosome
0.51	GO:0008097	5S rRNA binding
0.32	GO:0016787	hydrolase activity

0.61	GO:0005840	ribosome
0.47	GO:0005759	mitochondrial matrix
0.35	GO:0005615	extracellular space
0.33	GO:0031966	mitochondrial membrane
0.33	GO:0019866	organelle inner membrane
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016787

tr|T1EFH6|T1EFH6_HELRO
Uncharacterized protein
Search

0.44	GO:0010780	meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
0.44	GO:0010705	meiotic DNA double-strand break processing involved in reciprocal meiotic recombination
0.40	GO:1903506	regulation of nucleic acid-templated transcription
0.40	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.40	GO:0010468	regulation of gene expression
0.39	GO:0060026	convergent extension
0.38	GO:0006366	transcription by RNA polymerase II
0.38	GO:1902680	positive regulation of RNA biosynthetic process
0.38	GO:1902679	negative regulation of RNA biosynthetic process
0.35	GO:0071222	cellular response to lipopolysaccharide

0.51	GO:0003676	nucleic acid binding
0.49	GO:0008270	zinc ion binding
0.40	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.39	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding

0.50	GO:0005634	nucleus
0.41	GO:0031974	membrane-enclosed lumen
0.40	GO:0000785	chromatin
0.39	GO:0045111	intermediate filament cytoskeleton
0.37	GO:0005829	cytosol
0.34	GO:0032126	eisosome
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

tr|T1EFH7|T1EFH7_HELRO
Uncharacterized protein
Search

0.50	GO:0021819	layer formation in cerebral cortex
0.49	GO:0021591	ventricular system development
0.44	GO:0046488	phosphatidylinositol metabolic process
0.35	GO:0008654	phospholipid biosynthetic process
0.35	GO:0030258	lipid modification

0.53	GO:0016746	transferase activity, transferring acyl groups
0.34	GO:0005509	calcium ion binding

0.30

GO:0031224

intrinsic component of membrane

0.53

EC:2.3

GO:0016746

tr|T1EFH8|T1EFH8_HELRO
Non-specific serine/threonine protein kinase
Search

0.58	Non-specific serine/threonine protein kinase

0.63	GO:0006468	protein phosphorylation
0.43	GO:0032007	negative regulation of TOR signaling
0.43	GO:0042595	behavioral response to starvation
0.43	GO:0030730	sequestering of triglyceride
0.42	GO:0042331	phototaxis
0.42	GO:0045792	negative regulation of cell size
0.42	GO:0044058	regulation of digestive system process
0.42	GO:0009267	cellular response to starvation
0.42	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
0.41	GO:0048813	dendrite morphogenesis

0.70	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0035173	histone kinase activity
0.39	GO:0060089	molecular transducer activity
0.34	GO:0004402	histone acetyltransferase activity
0.34	GO:0003712	transcription cofactor activity
0.33	GO:0000049	tRNA binding

0.39	GO:0031588	nucleotide-activated protein kinase complex
0.38	GO:0005634	nucleus
0.35	GO:0000139	Golgi membrane
0.34	GO:0043025	neuronal cell body
0.34	GO:0030424	axon
0.30	GO:0016021	integral component of membrane

0.70

GO:0004674

tr|T1EFH9|T1EFH9_HELRO
Uncharacterized protein
Search

0.69	GO:0018108	peptidyl-tyrosine phosphorylation
0.58	GO:0001865	NK T cell differentiation
0.56	GO:0032633	interleukin-4 production
0.55	GO:0007202	activation of phospholipase C activity
0.55	GO:0032609	interferon-gamma production
0.54	GO:0050852	T cell receptor signaling pathway
0.52	GO:0002250	adaptive immune response
0.50	GO:0035556	intracellular signal transduction
0.48	GO:0046777	protein autophosphorylation
0.48	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway

0.69	GO:0004713	protein tyrosine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0005102	receptor binding
0.43	GO:0019199	transmembrane receptor protein kinase activity
0.43	GO:0004674	protein serine/threonine kinase activity
0.39	GO:0017108	5'-flap endonuclease activity
0.38	GO:0010857	calcium-dependent protein kinase activity

0.50	GO:0005911	cell-cell junction
0.46	GO:0005634	nucleus
0.45	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.37	GO:0009574	preprophase band
0.37	GO:0070013	intracellular organelle lumen
0.37	GO:0009524	phragmoplast
0.36	GO:0120025	plasma membrane bounded cell projection
0.36	GO:0005819	spindle
0.36	GO:0005887	integral component of plasma membrane
0.36	GO:0055044	symplast

0.69

GO:0004713

tr|T1EFI0|T1EFI0_HELRO
Uncharacterized protein
Search

0.89	Density-regulated protein homolog

0.72	GO:0006413	translational initiation
0.45	GO:0046628	positive regulation of insulin receptor signaling pathway
0.45	GO:0035076	ecdysone receptor-mediated signaling pathway
0.44	GO:0002181	cytoplasmic translation
0.43	GO:0045948	positive regulation of translational initiation
0.42	GO:0008284	positive regulation of cell proliferation
0.38	GO:0022618	ribonucleoprotein complex assembly
0.35	GO:0006486	protein glycosylation
0.34	GO:0030488	tRNA methylation
0.34	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

0.73	GO:0003743	translation initiation factor activity
0.44	GO:0003729	mRNA binding
0.38	GO:0043022	ribosome binding
0.35	GO:0052906	tRNA (guanine(37)-N(1))-methyltransferase activity
0.35	GO:0030246	carbohydrate binding
0.34	GO:0016757	transferase activity, transferring glycosyl groups
0.34	GO:0005509	calcium ion binding
0.34	GO:0004089	carbonate dehydratase activity

0.41	GO:0070992	translation initiation complex
0.38	GO:0043234	protein complex
0.36	GO:0005840	ribosome
0.35	GO:0005794	Golgi apparatus
0.35	GO:0005759	mitochondrial matrix
0.34	GO:0098588	bounding membrane of organelle
0.34	GO:0031984	organelle subcompartment
0.33	GO:0005634	nucleus
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.35

EC:2.1.1.228

GO:0052906

tr|T1EFI1|T1EFI1_HELRO
Uncharacterized protein
Search

MFSD13A

0.95	Major facilitator superfamily domain containing 13A

0.32

GO:0007165

signal transduction

0.30

GO:0044425

membrane part

tr|T1EFI2|T1EFI2_HELRO
Uncharacterized protein
Search

tr|T1EFI3|T1EFI3_HELRO
Uncharacterized protein
Search

0.45	Serine/threonine-protein kinase PLK

0.63	GO:0006468	protein phosphorylation
0.46	GO:0070194	synaptonemal complex disassembly
0.46	GO:0051081	nuclear envelope disassembly
0.46	GO:0016321	female meiosis chromosome segregation
0.45	GO:0090435	protein localization to nuclear envelope
0.45	GO:0072425	signal transduction involved in G2 DNA damage checkpoint
0.45	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
0.45	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
0.45	GO:1901673	regulation of mitotic spindle assembly
0.45	GO:0071168	protein localization to chromatin

0.70	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.44	GO:0010997	anaphase-promoting complex binding
0.43	GO:0019901	protein kinase binding
0.42	GO:0008017	microtubule binding
0.41	GO:0042802	identical protein binding
0.39	GO:0000287	magnesium ion binding

0.44	GO:0000795	synaptonemal complex
0.44	GO:0051233	spindle midzone
0.44	GO:0030496	midbody
0.44	GO:0005876	spindle microtubule
0.44	GO:0000942	condensed nuclear chromosome outer kinetochore
0.43	GO:0000922	spindle pole
0.43	GO:0005813	centrosome
0.41	GO:0000785	chromatin

0.70

GO:0004674

tr|T1EFI4|T1EFI4_HELRO
Uncharacterized protein
Search

tr|T1EFI5|T1EFI5_HELRO
Phosphodiesterase
Search

0.21	Phosphodiesterase

0.60	GO:0007165	signal transduction
0.50	GO:0071364	cellular response to epidermal growth factor stimulus
0.48	GO:1903206	negative regulation of hydrogen peroxide-induced cell death
0.48	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.44	GO:1903506	regulation of nucleic acid-templated transcription
0.44	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.43	GO:0010468	regulation of gene expression
0.37	GO:0006198	cAMP catabolic process
0.36	GO:0035106	operant conditioning
0.36	GO:0090032	negative regulation of steroid hormone biosynthetic process

0.79	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.53	GO:0046872	metal ion binding
0.45	GO:0019900	kinase binding

0.35	GO:0070062	extracellular exosome
0.33	GO:0005622	intracellular

0.79

EC:3.1.4.17

GO:0004114

tr|T1EFI6|T1EFI6_HELRO
Uncharacterized protein
Search

POLR1A

0.48	DNA-directed RNA polymerase subunit

0.60	GO:1904750	negative regulation of protein localization to nucleolus
0.58	GO:0006351	transcription, DNA-templated
0.44	GO:0048703	embryonic viscerocranium morphogenesis
0.43	GO:0014032	neural crest cell development
0.36	GO:0040029	regulation of gene expression, epigenetic
0.34	GO:0016458	gene silencing
0.34	GO:0097503	sialylation
0.34	GO:0006325	chromatin organization
0.34	GO:0010628	positive regulation of gene expression
0.34	GO:0045892	negative regulation of transcription, DNA-templated

0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.63	GO:0008270	zinc ion binding
0.55	GO:0003677	DNA binding
0.51	GO:0003682	chromatin binding
0.34	GO:0005515	protein binding
0.34	GO:0008373	sialyltransferase activity

0.61	GO:0005634	nucleus
0.52	GO:0000428	DNA-directed RNA polymerase complex
0.48	GO:0031974	membrane-enclosed lumen
0.44	GO:0043232	intracellular non-membrane-bounded organelle
0.43	GO:0044446	intracellular organelle part

0.70

GO:0003899

tr|T1EFI7|T1EFI7_HELRO
Uncharacterized protein
Search

BTRC

0.91	Beta-transducin repeat containing

0.53	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
0.52	GO:0042753	positive regulation of circadian rhythm
0.52	GO:0031648	protein destabilization
0.51	GO:0033598	mammary gland epithelial cell proliferation
0.51	GO:0060444	branching involved in mammary gland duct morphogenesis
0.50	GO:0000209	protein polyubiquitination
0.50	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
0.50	GO:0060828	regulation of canonical Wnt signaling pathway
0.49	GO:0061136	regulation of proteasomal protein catabolic process
0.49	GO:0045862	positive regulation of proteolysis

0.68	GO:0046983	protein dimerization activity
0.51	GO:0045309	protein phosphorylated amino acid binding
0.51	GO:0008013	beta-catenin binding
0.48	GO:0061630	ubiquitin protein ligase activity
0.35	GO:0016905	myosin heavy chain kinase activity
0.33	GO:0016874	ligase activity

0.50	GO:0019005	SCF ubiquitin ligase complex
0.42	GO:0005634	nucleus
0.37	GO:0005737	cytoplasm
0.33	GO:0043233	organelle lumen
0.32	GO:0044446	intracellular organelle part

0.35

GO:0016905

tr|T1EFI8|T1EFI8_HELRO
Uncharacterized protein
Search

0.41	Nicotinic acid phosphoribosyltransferase

0.81	GO:0019358	nicotinate nucleotide salvage
0.73	GO:0009435	NAD biosynthetic process
0.35	GO:0006979	response to oxidative stress

0.79	GO:0004516	nicotinate phosphoribosyltransferase activity
0.78	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity
0.33	GO:0003779	actin binding
0.33	GO:0003676	nucleic acid binding

0.35	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.79	EC:2.4.2.11	GO:0004516
0.79	KEGG:R01724	GO:0004516

tr|T1EFI9|T1EFI9_HELRO
Uncharacterized protein
Search

0.97	Lethal(2) giant larvae protein (Fragment)

0.53	GO:0017157	regulation of exocytosis
0.52	GO:0050708	regulation of protein secretion
0.50	GO:0043547	positive regulation of GTPase activity

0.54	GO:0019905	syntaxin binding
0.53	GO:0017137	Rab GTPase binding
0.51	GO:0005096	GTPase activator activity
0.45	GO:0005509	calcium ion binding
0.44	GO:0008270	zinc ion binding
0.39	GO:0003676	nucleic acid binding

0.43	GO:0005634	nucleus
0.42	GO:0005886	plasma membrane
0.39	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

tr|T1EFJ0|T1EFJ0_HELRO
Uncharacterized protein
Search

0.10	RNA-binding protein Nova-1, putative (Fragment)

0.56	GO:0000398	mRNA splicing, via spliceosome
0.40	GO:0040040	thermosensory behavior
0.39	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.34	GO:0021510	spinal cord development
0.32	GO:0006913	nucleocytoplasmic transport
0.31	GO:1903506	regulation of nucleic acid-templated transcription
0.31	GO:2000112	regulation of cellular macromolecule biosynthetic process

0.59	GO:0003723	RNA binding
0.32	GO:0016787	hydrolase activity

0.42	GO:0005730	nucleolus
0.32	GO:0005643	nuclear pore
0.30	GO:0016020	membrane

0.32

GO:0016787

tr|T1EFJ1|T1EFJ1_HELRO
Uncharacterized protein
Search

LUC7L3

0.92	Cisplatin resistance-associated overexpressed protein (Fragment)

0.84	GO:0006376	mRNA splice site selection
0.33	GO:0046579	positive regulation of Ras protein signal transduction
0.33	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.33	GO:0007018	microtubule-based movement

0.76	GO:0003729	mRNA binding
0.34	GO:0003677	DNA binding
0.34	GO:0003777	microtubule motor activity
0.33	GO:0005515	protein binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.82	GO:0005685	U1 snRNP
0.47	GO:0016607	nuclear speck
0.46	GO:0071004	U2-type prespliceosome
0.33	GO:0005871	kinesin complex
0.30	GO:0016020	membrane

tr|T1EFJ2|T1EFJ2_HELRO
Uncharacterized protein
Search

0.47	GO:0030199	collagen fibril organization
0.44	GO:0060216	definitive hemopoiesis
0.44	GO:0045747	positive regulation of Notch signaling pathway
0.44	GO:0002244	hematopoietic progenitor cell differentiation
0.43	GO:0001525	angiogenesis
0.37	GO:0007219	Notch signaling pathway
0.37	GO:0098609	cell-cell adhesion
0.35	GO:0050793	regulation of developmental process
0.35	GO:0009190	cyclic nucleotide biosynthetic process
0.34	GO:0035556	intracellular signal transduction

0.50	GO:0008061	chitin binding
0.38	GO:0046872	metal ion binding
0.36	GO:0030246	carbohydrate binding
0.35	GO:0016849	phosphorus-oxygen lyase activity

0.44	GO:0005578	proteinaceous extracellular matrix
0.32	GO:0005622	intracellular
0.30	GO:0016020	membrane

0.35

EC:4.6

GO:0016849

tr|T1EFJ3|T1EFJ3_HELRO
Uncharacterized protein
Search

0.61	GO:0007165	signal transduction
0.38	GO:0043087	regulation of GTPase activity
0.36	GO:0051345	positive regulation of hydrolase activity
0.35	GO:0007415	defasciculation of motor neuron axon
0.35	GO:0045792	negative regulation of cell size
0.35	GO:0016319	mushroom body development
0.34	GO:0050770	regulation of axonogenesis

0.57	GO:0003924	GTPase activity
0.56	GO:0032550	purine ribonucleoside binding
0.56	GO:0019001	guanyl nucleotide binding
0.47	GO:0032555	purine ribonucleotide binding
0.47	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0005096	GTPase activator activity
0.35	GO:0030215	semaphorin receptor binding

0.33

GO:0005829

cytosol

tr|T1EFJ4|T1EFJ4_HELRO
NEDD8-activating enzyme E1 regulatory subunit
Search

NAE1

0.73	NEDD8-activating enzyme E1 regulatory subunit

0.83	GO:0045116	protein neddylation
0.52	GO:0051402	neuron apoptotic process
0.51	GO:0033314	mitotic DNA replication checkpoint
0.50	GO:0043523	regulation of neuron apoptotic process
0.34	GO:0043687	post-translational protein modification
0.33	GO:0007165	signal transduction
0.32	GO:0007018	microtubule-based movement

0.84	GO:0019781	NEDD8 activating enzyme activity
0.49	GO:0031625	ubiquitin protein ligase binding
0.47	GO:0046982	protein heterodimerization activity
0.32	GO:0003777	microtubule motor activity

0.36	GO:0005737	cytoplasm
0.34	GO:0005886	plasma membrane
0.32	GO:0005868	cytoplasmic dynein complex

tr|T1EFJ5|T1EFJ5_HELRO
Uncharacterized protein
Search

EIF4E

0.75	Eukaryotic translation initiation factor 4ea

0.72	GO:0006413	translational initiation
0.48	GO:0071549	cellular response to dexamethasone stimulus
0.48	GO:0001662	behavioral fear response
0.46	GO:0019827	stem cell population maintenance
0.46	GO:0045665	negative regulation of neuron differentiation
0.44	GO:0017148	negative regulation of translation
0.44	GO:0000082	G1/S transition of mitotic cell cycle
0.43	GO:0045931	positive regulation of mitotic cell cycle
0.38	GO:0030324	lung development
0.35	GO:0010507	negative regulation of autophagy

0.73	GO:0003743	translation initiation factor activity
0.65	GO:0031370	eukaryotic initiation factor 4G binding
0.62	GO:0070491	repressing transcription factor binding
0.53	GO:0019899	enzyme binding
0.46	GO:0000340	RNA 7-methylguanosine cap binding
0.33	GO:0046983	protein dimerization activity

0.58	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0005845	mRNA cap binding complex
0.48	GO:0033391	chromatoid body
0.47	GO:0016281	eukaryotic translation initiation factor 4F complex
0.44	GO:0016442	RISC complex
0.44	GO:0000932	P-body
0.44	GO:0010494	cytoplasmic stress granule
0.41	GO:0005829	cytosol
0.35	GO:0070062	extracellular exosome
0.34	GO:0097482	muscle cell postsynaptic specialization

tr|T1EFJ6|T1EFJ6_HELRO
Signal recognition particle subunit SRP68
Search

SRP68

0.70	Signal recognition particle subunit SRP68

0.74	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.46	GO:0042493	response to drug

0.83	GO:0030942	endoplasmic reticulum signal peptide binding
0.83	GO:0005047	signal recognition particle binding
0.77	GO:0008312	7S RNA binding
0.48	GO:0019904	protein domain specific binding
0.47	GO:0043022	ribosome binding

0.80	GO:0005786	signal recognition particle, endoplasmic reticulum targeting
0.50	GO:0005925	focal adhesion
0.45	GO:0005829	cytosol
0.42	GO:0005783	endoplasmic reticulum
0.36	GO:0005730	nucleolus
0.33	GO:0005840	ribosome

tr|T1EFJ7|T1EFJ7_HELRO
Uncharacterized protein
Search

0.61	GO:0016318	ommatidial rotation
0.60	GO:0008407	chaeta morphogenesis
0.60	GO:0008587	imaginal disc-derived wing margin morphogenesis
0.56	GO:0097305	response to alcohol
0.53	GO:0007399	nervous system development
0.50	GO:0030199	collagen fibril organization
0.49	GO:0060216	definitive hemopoiesis
0.48	GO:0048584	positive regulation of response to stimulus
0.47	GO:0002244	hematopoietic progenitor cell differentiation
0.47	GO:0008593	regulation of Notch signaling pathway

0.42	GO:0008134	transcription factor binding
0.40	GO:0030674	protein binding, bridging
0.40	GO:0038187	pattern recognition receptor activity
0.40	GO:0004871	signal transducer activity
0.40	GO:0003823	antigen binding
0.39	GO:0097367	carbohydrate derivative binding
0.39	GO:0005102	receptor binding
0.37	GO:0030554	adenyl nucleotide binding
0.37	GO:0030246	carbohydrate binding
0.37	GO:0099600	transmembrane receptor activity

0.48	GO:0044421	extracellular region part
0.42	GO:0005581	collagen trimer
0.41	GO:0031232	extrinsic component of external side of plasma membrane
0.38	GO:0005770	late endosome
0.30	GO:0016021	integral component of membrane

tr|T1EFJ8|T1EFJ8_HELRO
Uncharacterized protein
Search

RNF144A

0.56	RING-type E3 ubiquitin transferase

0.73	GO:0016567	protein ubiquitination
0.43	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.40	GO:0006511	ubiquitin-dependent protein catabolic process
0.34	GO:0051607	defense response to virus
0.33	GO:0001522	pseudouridine synthesis
0.33	GO:0042254	ribosome biogenesis

0.74	GO:0004842	ubiquitin-protein transferase activity
0.54	GO:0046872	metal ion binding
0.51	GO:0016874	ligase activity
0.43	GO:0031624	ubiquitin conjugating enzyme binding
0.41	GO:0061659	ubiquitin-like protein ligase activity
0.34	GO:0030515	snoRNA binding
0.33	GO:0051536	iron-sulfur cluster binding

0.45	GO:0005794	Golgi apparatus
0.41	GO:0000151	ubiquitin ligase complex
0.34	GO:0005811	lipid droplet
0.34	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.51	EC:6	GO:0016874
0.74	KEGG:R03876	GO:0004842

tr|T1EFJ9|T1EFJ9_HELRO
Uncharacterized protein
Search

0.79	Cortical sodium-D-glucose cotransporter (Predicted)

0.55	GO:0055085	transmembrane transport
0.49	GO:0015758	glucose transport
0.44	GO:0006814	sodium ion transport
0.38	GO:0015798	myo-inositol transport
0.37	GO:0106001	intestinal hexose absorption
0.36	GO:0006020	inositol metabolic process
0.36	GO:0001656	metanephros development
0.34	GO:0043576	regulation of respiratory gaseous exchange
0.34	GO:0007422	peripheral nervous system development
0.32	GO:1903506	regulation of nucleic acid-templated transcription

0.57

GO:0022857

transmembrane transporter activity

0.43	GO:0005887	integral component of plasma membrane
0.37	GO:0005903	brush border
0.37	GO:0016324	apical plasma membrane
0.36	GO:0031253	cell projection membrane
0.35	GO:0005911	cell-cell junction
0.34	GO:0070062	extracellular exosome
0.32	GO:0005634	nucleus

tr|T1EFK0|T1EFK0_HELRO
Uncharacterized protein
Search

AARSD1

0.82	Alanyl-tRNA synthetase domain-containing protein 1

0.74	GO:0006419	alanyl-tRNA aminoacylation
0.49	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity

0.74	GO:0004813	alanine-tRNA ligase activity
0.59	GO:0002196	Ser-tRNA(Ala) hydrolase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0032553	ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0003676	nucleic acid binding

0.74

EC:6.1.1.7

GO:0004813

tr|T1EFK1|T1EFK1_HELRO
Uncharacterized protein
Search

0.40	GO:0032501	multicellular organismal process
0.40	GO:0005975	carbohydrate metabolic process
0.40	GO:0006030	chitin metabolic process
0.40	GO:0030154	cell differentiation
0.39	GO:0048856	anatomical structure development
0.38	GO:0006898	receptor-mediated endocytosis
0.37	GO:0007016	cytoskeletal anchoring at plasma membrane
0.37	GO:0019538	protein metabolic process
0.37	GO:0051451	myoblast migration
0.37	GO:0008078	mesodermal cell migration

0.56	GO:0005509	calcium ion binding
0.40	GO:0030246	carbohydrate binding
0.40	GO:0008061	chitin binding
0.39	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.38	GO:0030229	very-low-density lipoprotein particle receptor activity
0.38	GO:0140096	catalytic activity, acting on a protein
0.38	GO:0001871	pattern binding
0.37	GO:0005272	sodium channel activity
0.36	GO:0016791	phosphatase activity
0.36	GO:0017171	serine hydrolase activity

0.45	GO:0005576	extracellular region
0.37	GO:0016010	dystrophin-associated glycoprotein complex
0.36	GO:0005581	collagen trimer
0.30	GO:0016021	integral component of membrane

0.39

GO:0004553

tr|T1EFK2|T1EFK2_HELRO
Uncharacterized protein
Search

0.91	CXXC finger protein 1

0.55	GO:0030097	hemopoiesis
0.52	GO:0001568	blood vessel development
0.51	GO:0032776	DNA methylation on cytosine
0.41	GO:0030154	cell differentiation
0.37	GO:0051568	histone H3-K4 methylation
0.36	GO:0045893	positive regulation of transcription, DNA-templated

0.73	GO:0045322	unmethylated CpG binding
0.63	GO:0008270	zinc ion binding
0.37	GO:0042800	histone methyltransferase activity (H3-K4 specific)

0.67	GO:0048188	Set1C/COMPASS complex
0.37	GO:0016363	nuclear matrix
0.37	GO:0016607	nuclear speck
0.35	GO:0005829	cytosol

tr|T1EFK3|T1EFK3_HELRO
Uncharacterized protein
Search

SMURF2

0.85	SMAD specific E3 ubiquitin protein ligase 2

0.71	GO:0016567	protein ubiquitination
0.68	GO:0006511	ubiquitin-dependent protein catabolic process
0.51	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
0.51	GO:0090288	negative regulation of cellular response to growth factor stimulus
0.50	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.49	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
0.48	GO:1901165	positive regulation of trophoblast cell migration
0.48	GO:0030510	regulation of BMP signaling pathway
0.42	GO:0061753	substrate localization to autophagosome
0.42	GO:0061736	engulfment of target by autophagosome

0.71	GO:0004842	ubiquitin-protein transferase activity
0.71	GO:0061659	ubiquitin-like protein ligase activity
0.53	GO:0016874	ligase activity
0.49	GO:0046332	SMAD binding
0.43	GO:0042802	identical protein binding
0.37	GO:0005160	transforming growth factor beta receptor binding
0.34	GO:0061608	nuclear import signal receptor activity
0.33	GO:0008565	protein transporter activity

0.45	GO:0016607	nuclear speck
0.44	GO:0000151	ubiquitin ligase complex
0.37	GO:0098857	membrane microdomain
0.37	GO:0005737	cytoplasm
0.36	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.53	EC:6	GO:0016874
0.71	KEGG:R03876	GO:0004842

tr|T1EFK4|T1EFK4_HELRO
Uncharacterized protein
Search

CAPN5

0.91

Calpain-5

0.61	GO:0006508	proteolysis
0.53	GO:0051493	regulation of cytoskeleton organization
0.38	GO:0001578	microtubule bundle formation
0.35	GO:0007586	digestion
0.33	GO:0007165	signal transduction
0.32	GO:0006468	protein phosphorylation

0.82	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.38	GO:0005509	calcium ion binding
0.37	GO:0008017	microtubule binding
0.32	GO:0004672	protein kinase activity
0.31	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0005622	intracellular
0.43	GO:0009986	cell surface
0.37	GO:0099512	supramolecular fiber
0.35	GO:0043228	non-membrane-bounded organelle
0.34	GO:0044422	organelle part
0.34	GO:0005925	focal adhesion
0.34	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

tr|T1EFK5|T1EFK5_HELRO
Uncharacterized protein
Search

tr|T1EFK6|T1EFK6_HELRO
Uncharacterized protein
Search

CSTF2

0.81	Cleavage stimulation factor subunit 2

0.78	GO:0031124	mRNA 3'-end processing
0.77	GO:0043631	RNA polyadenylation
0.46	GO:0098787	mRNA cleavage involved in mRNA processing
0.39	GO:1990090	cellular response to nerve growth factor stimulus
0.35	GO:0006369	termination of RNA polymerase II transcription
0.35	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation
0.34	GO:0000398	mRNA splicing, via spliceosome
0.34	GO:0006886	intracellular protein transport
0.34	GO:0016192	vesicle-mediated transport

0.58	GO:0003723	RNA binding
0.33	GO:0005515	protein binding

0.80	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
0.50	GO:0016604	nuclear body

tr|T1EFK7|T1EFK7_HELRO
Palmitoyltransferase
Search

0.51	Palmitoyltransferase

0.45	GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
0.45	GO:0018345	protein palmitoylation
0.45	GO:0048733	sebaceous gland development
0.43	GO:0001942	hair follicle development
0.33	GO:0006420	arginyl-tRNA aminoacylation
0.33	GO:0050790	regulation of catalytic activity
0.33	GO:0045861	negative regulation of proteolysis
0.32	GO:0044092	negative regulation of molecular function
0.32	GO:0055114	oxidation-reduction process

0.80	GO:0019706	protein-cysteine S-palmitoyltransferase activity
0.33	GO:0004814	arginine-tRNA ligase activity
0.33	GO:0004792	thiosulfate sulfurtransferase activity
0.33	GO:0004866	endopeptidase inhibitor activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0016491	oxidoreductase activity
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.43	GO:0012505	endomembrane system
0.39	GO:0043231	intracellular membrane-bounded organelle
0.39	GO:0044444	cytoplasmic part
0.37	GO:0005886	plasma membrane
0.33	GO:0031984	organelle subcompartment
0.33	GO:0005615	extracellular space
0.32	GO:0098588	bounding membrane of organelle
0.30	GO:0016021	integral component of membrane

0.80	EC:2.3.1.225	GO:0019706
0.33	KEGG:R01931	GO:0004792

tr|T1EFK8|T1EFK8_HELRO
UDP-glucuronosyltransferase
Search

0.35	UDP-glucuronosyltransferase

0.36	GO:0016999	antibiotic metabolic process
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:0010468	regulation of gene expression
0.31	GO:0055114	oxidation-reduction process
0.31	GO:0009058	biosynthetic process

0.74	GO:0015020	glucuronosyltransferase activity
0.33	GO:0043565	sequence-specific DNA binding
0.32	GO:0003700	DNA binding transcription factor activity
0.32	GO:0031177	phosphopantetheine binding
0.31	GO:0016491	oxidoreductase activity

0.43	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0044425	membrane part

0.74

EC:2.4.1.17

GO:0015020

tr|T1EFK9|T1EFK9_HELRO
Uncharacterized protein
Search

0.77	GO:0016055	Wnt signaling pathway
0.60	GO:0035556	intracellular signal transduction
0.37	GO:0090175	regulation of establishment of planar polarity

0.37

GO:0005109

frizzled binding

0.44	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

tr|T1EFL0|T1EFL0_HELRO
Uncharacterized protein
Search

0.52	Carboxypeptidase E

0.63	GO:0030070	insulin processing
0.58	GO:0003214	cardiac left ventricle morphogenesis
0.52	GO:0016055	Wnt signaling pathway
0.50	GO:0072657	protein localization to membrane
0.37	GO:2000173	negative regulation of branching morphogenesis of a nerve
0.37	GO:0034230	enkephalin processing
0.35	GO:0007218	neuropeptide signaling pathway
0.35	GO:0043171	peptide catabolic process
0.33	GO:0036211	protein modification process
0.33	GO:0044267	cellular protein metabolic process

0.77	GO:0004181	metallocarboxypeptidase activity
0.63	GO:0008270	zinc ion binding
0.57	GO:0042043	neurexin family protein binding
0.54	GO:0050839	cell adhesion molecule binding
0.46	GO:0004185	serine-type carboxypeptidase activity
0.35	GO:0050897	cobalt ion binding
0.35	GO:0019904	protein domain specific binding

0.52	GO:0005615	extracellular space
0.52	GO:0005794	Golgi apparatus
0.48	GO:0043025	neuronal cell body
0.48	GO:0030141	secretory granule
0.47	GO:0097060	synaptic membrane
0.43	GO:0030658	transport vesicle membrane
0.37	GO:1903561	extracellular vesicle
0.35	GO:0030425	dendrite
0.35	GO:0045121	membrane raft
0.33	GO:0005634	nucleus

0.77

GO:0004181

tr|T1EFL1|T1EFL1_HELRO
Uncharacterized protein
Search

SLO-1

0.78	Calcium-activated BK potassium channel alpha subunit

0.73	GO:0071805	potassium ion transmembrane transport
0.38	GO:0043050	pharyngeal pumping
0.37	GO:0048149	behavioral response to ethanol
0.37	GO:0046928	regulation of neurotransmitter secretion
0.37	GO:0045214	sarcomere organization
0.35	GO:0040011	locomotion

0.85	GO:0060072	large conductance calcium-activated potassium channel activity
0.75	GO:0005249	voltage-gated potassium channel activity
0.32	GO:0046872	metal ion binding

0.75	GO:0008076	voltage-gated potassium channel complex
0.37	GO:0055120	striated muscle dense body
0.37	GO:0031430	M band
0.36	GO:0045202	synapse

tr|T1EFL2|T1EFL2_HELRO
Uncharacterized protein
Search

A1CF

0.95	APOBEC1 complementation factor

0.72	GO:0016556	mRNA modification
0.54	GO:0010609	mRNA localization resulting in posttranscriptional regulation of gene expression
0.53	GO:0016554	cytidine to uridine editing
0.50	GO:0007566	embryo implantation
0.38	GO:0050821	protein stabilization
0.37	GO:0006397	mRNA processing

0.72	GO:0003727	single-stranded RNA binding
0.38	GO:0003725	double-stranded RNA binding
0.35	GO:0005515	protein binding
0.34	GO:0003729	mRNA binding

0.82	GO:0030895	apolipoprotein B mRNA editing enzyme complex
0.46	GO:0005654	nucleoplasm
0.38	GO:0005737	cytoplasm
0.36	GO:0012505	endomembrane system
0.35	GO:0045293	mRNA editing complex
0.35	GO:0005720	nuclear heterochromatin
0.30	GO:0031224	intrinsic component of membrane

tr|T1EFL3|T1EFL3_HELRO
Uncharacterized protein
Search

PRKAG1

0.75	AMP-Activated protein Kinase Gamma subunit

0.57	GO:0042595	behavioral response to starvation
0.57	GO:0030730	sequestering of triglyceride
0.56	GO:0016310	phosphorylation
0.54	GO:0042632	cholesterol homeostasis
0.53	GO:0048518	positive regulation of biological process
0.51	GO:0006914	autophagy
0.51	GO:0009267	cellular response to starvation
0.49	GO:0051726	regulation of cell cycle
0.47	GO:0051170	nuclear import
0.45	GO:0006629	lipid metabolic process

0.58	GO:0016301	kinase activity
0.55	GO:0019901	protein kinase binding
0.42	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.41	GO:0140096	catalytic activity, acting on a protein
0.38	GO:0016208	AMP binding
0.37	GO:0044212	transcription regulatory region DNA binding
0.37	GO:0043531	ADP binding
0.36	GO:0008603	cAMP-dependent protein kinase regulator activity
0.35	GO:0060089	molecular transducer activity
0.35	GO:0016278	lysine N-methyltransferase activity

0.49	GO:0005634	nucleus
0.39	GO:0005737	cytoplasm
0.38	GO:0031588	nucleotide-activated protein kinase complex
0.37	GO:0034708	methyltransferase complex
0.37	GO:0043233	organelle lumen
0.36	GO:0070062	extracellular exosome
0.35	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.42

GO:0016773

tr|T1EFL4|T1EFL4_HELRO
Solute carrier organic anion transporter family member
Search

0.34	Solute carrier organic anion transporter family member

0.58	GO:0006811	ion transport
0.55	GO:0055085	transmembrane transport
0.41	GO:0071702	organic substance transport

0.56

GO:0005215

transporter activity

0.55	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

tr|T1EFL5|T1EFL5_HELRO
Uncharacterized protein
Search

TMEM62

0.44	Transmembrane protein 62

0.35	GO:0000245	spliceosomal complex assembly
0.34	GO:0055085	transmembrane transport
0.34	GO:0006811	ion transport
0.31	GO:0009058	biosynthetic process

0.50	GO:0016787	hydrolase activity
0.36	GO:0005230	extracellular ligand-gated ion channel activity
0.32	GO:0003676	nucleic acid binding
0.32	GO:0030170	pyridoxal phosphate binding

0.33	GO:0005634	nucleus
0.30	GO:0044425	membrane part

0.50

GO:0016787

tr|T1EFL6|T1EFL6_HELRO
Uncharacterized protein
Search

0.86	GO:2000568	positive regulation of memory T cell activation
0.84	GO:0001916	positive regulation of T cell mediated cytotoxicity
0.81	GO:0032729	positive regulation of interferon-gamma production
0.41	GO:0002576	platelet degranulation
0.40	GO:0048538	thymus development
0.39	GO:0045580	regulation of T cell differentiation
0.35	GO:0006518	peptide metabolic process
0.35	GO:0043604	amide biosynthetic process
0.35	GO:0044267	cellular protein metabolic process
0.34	GO:1901566	organonitrogen compound biosynthetic process

0.86	GO:0023025	MHC class Ib protein complex binding
0.86	GO:0023029	MHC class Ib protein binding
0.36	GO:0003735	structural constituent of ribosome

0.72	GO:0005929	cilium
0.43	GO:0070062	extracellular exosome
0.41	GO:0031093	platelet alpha granule lumen
0.35	GO:0005840	ribosome
0.30	GO:0016020	membrane

tr|T1EFL7|T1EFL7_HELRO
Pyruvate kinase
Search

PKM

0.47	Pyruvate kinase PKM

0.70	GO:0006757	ATP generation from ADP
0.69	GO:0006090	pyruvate metabolic process
0.68	GO:0016052	carbohydrate catabolic process
0.67	GO:0019362	pyridine nucleotide metabolic process
0.46	GO:0032868	response to insulin
0.45	GO:0071375	cellular response to peptide hormone stimulus
0.43	GO:0012501	programmed cell death
0.38	GO:0014870	response to muscle inactivity
0.38	GO:0001666	response to hypoxia
0.38	GO:0007584	response to nutrient

0.78	GO:0004743	pyruvate kinase activity
0.77	GO:0030955	potassium ion binding
0.64	GO:0000287	magnesium ion binding
0.60	GO:0016301	kinase activity
0.44	GO:0045296	cadherin binding
0.38	GO:0070324	thyroid hormone binding
0.37	GO:0023026	MHC class II protein complex binding
0.36	GO:0043531	ADP binding
0.36	GO:0042802	identical protein binding
0.35	GO:0005524	ATP binding

0.44	GO:0043209	myelin sheath
0.42	GO:0005929	cilium
0.42	GO:0005829	cytosol
0.39	GO:1902912	pyruvate kinase complex
0.39	GO:0005634	nucleus
0.38	GO:0005739	mitochondrion
0.37	GO:0070062	extracellular exosome
0.35	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0031012	extracellular matrix
0.35	GO:0034774	secretory granule lumen

0.78

EC:2.7.1.40

GO:0004743

tr|T1EFL8|T1EFL8_HELRO
Uncharacterized protein
Search

0.76	GO:0034968	histone lysine methylation
0.37	GO:1900109	regulation of histone H3-K9 dimethylation
0.36	GO:0006302	double-strand break repair
0.36	GO:0006342	chromatin silencing
0.36	GO:0006338	chromatin remodeling
0.35	GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
0.35	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining
0.35	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.35	GO:0071157	negative regulation of cell cycle arrest
0.35	GO:0018027	peptidyl-lysine dimethylation

0.77	GO:0018024	histone-lysine N-methyltransferase activity
0.56	GO:0008270	zinc ion binding
0.42	GO:0002039	p53 binding
0.39	GO:0003676	nucleic acid binding
0.35	GO:0044547	DNA topoisomerase binding
0.35	GO:0004519	endonuclease activity
0.35	GO:0030145	manganese ion binding
0.34	GO:0042803	protein homodimerization activity
0.33	GO:0004536	deoxyribonuclease activity
0.32	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity

0.60	GO:0005634	nucleus
0.59	GO:0005694	chromosome
0.40	GO:0034708	methyltransferase complex
0.39	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.77

GO:0018024

tr|T1EFL9|T1EFL9_HELRO
Uncharacterized protein
Search

NAA15

0.38	N-alpha-acetyltransferase 15 NatA auxiliary subunit

0.52	GO:0017196	N-terminal peptidyl-methionine acetylation
0.44	GO:0050821	protein stabilization
0.44	GO:0043066	negative regulation of apoptotic process
0.42	GO:0045893	positive regulation of transcription, DNA-templated
0.35	GO:0001525	angiogenesis
0.34	GO:0030154	cell differentiation
0.33	GO:0006351	transcription, DNA-templated

0.50	GO:0016740	transferase activity
0.42	GO:0043022	ribosome binding
0.34	GO:0005515	protein binding

0.54	GO:0031415	NatA complex
0.43	GO:0005667	transcription factor complex
0.41	GO:0005829	cytosol
0.39	GO:0005634	nucleus
0.35	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0016021	integral component of membrane

0.50

GO:0016740

tr|T1EFM0|T1EFM0_HELRO
Cation-transporting ATPase
Search

ATP13A4

0.53	Cation-transporting ATPase

0.60	GO:0006812	cation transport
0.45	GO:0072503	cellular divalent inorganic cation homeostasis
0.45	GO:0055074	calcium ion homeostasis
0.44	GO:0006875	cellular metal ion homeostasis
0.42	GO:0099131	ATP hydrolysis coupled ion transmembrane transport
0.40	GO:0098660	inorganic ion transmembrane transport
0.37	GO:0007626	locomotory behavior
0.37	GO:0043009	chordate embryonic development
0.34	GO:0006457	protein folding
0.34	GO:1905165	regulation of lysosomal protein catabolic process

0.60	GO:0016887	ATPase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0046872	metal ion binding
0.44	GO:0015085	calcium ion transmembrane transporter activity
0.42	GO:0022853	active ion transmembrane transporter activity
0.41	GO:0015399	primary active transmembrane transporter activity
0.34	GO:0005230	extracellular ligand-gated ion channel activity

0.41	GO:0005887	integral component of plasma membrane
0.38	GO:0043231	intracellular membrane-bounded organelle
0.35	GO:0098805	whole membrane
0.35	GO:0098588	bounding membrane of organelle
0.34	GO:0044446	intracellular organelle part
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.34	GO:0044444	cytoplasmic part
0.34	GO:0097708	intracellular vesicle
0.33	GO:1990816	vacuole-mitochondrion membrane contact site

0.60

GO:0016887

tr|T1EFM1|T1EFM1_HELRO
Uncharacterized protein
Search

tr|T1EFM2|T1EFM2_HELRO
Uncharacterized protein
Search

ALDH9A1

0.96	4-trimethylaminobutyraldehyde dehydrogenase

0.59	GO:0042133	neurotransmitter metabolic process
0.59	GO:0031456	glycine betaine biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.45	GO:0006081	cellular aldehyde metabolic process
0.39	GO:0045329	carnitine biosynthetic process
0.36	GO:0045892	negative regulation of transcription, DNA-templated
0.34	GO:0001889	liver development
0.34	GO:0001822	kidney development
0.34	GO:0006351	transcription, DNA-templated
0.34	GO:0042445	hormone metabolic process

0.69	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.44	GO:0046872	metal ion binding
0.34	GO:0003700	DNA binding transcription factor activity
0.34	GO:0033737	1-pyrroline dehydrogenase activity
0.34	GO:0043176	amine binding
0.34	GO:0003677	DNA binding
0.34	GO:0042803	protein homodimerization activity
0.33	GO:0051287	NAD binding

0.35	GO:0070062	extracellular exosome
0.35	GO:0005829	cytosol
0.33	GO:0005739	mitochondrion

0.69

GO:0016620

tr|T1EFM3|T1EFM3_HELRO
Uncharacterized protein
Search

0.35	Large neutral amino acids transporter small subunit 2

0.55	GO:0055085	transmembrane transport
0.37	GO:0006865	amino acid transport
0.33	GO:0071804	cellular potassium ion transport

0.57

GO:0022857

transmembrane transporter activity

0.35

GO:0005887

integral component of plasma membrane

tr|T1EFM4|T1EFM4_HELRO
Uncharacterized protein
Search

EIF4A1

0.61	Translation initiation factor 4F, helicase subunit

0.70	GO:0006413	translational initiation
0.43	GO:0010501	RNA secondary structure unwinding
0.40	GO:0002181	cytoplasmic translation
0.37	GO:0060255	regulation of macromolecule metabolic process
0.32	GO:0006508	proteolysis
0.32	GO:0055114	oxidation-reduction process

0.74	GO:0004004	ATP-dependent RNA helicase activity
0.70	GO:0003743	translation initiation factor activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0003725	double-stranded RNA binding
0.33	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
0.33	GO:0008234	cysteine-type peptidase activity
0.33	GO:0005515	protein binding

0.41	GO:0005730	nucleolus
0.36	GO:0005737	cytoplasm
0.35	GO:0031012	extracellular matrix
0.34	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:1.13.11

GO:0016702

tr|T1EFM5|T1EFM5_HELRO
Uncharacterized protein
Search

tr|T1EFM6|T1EFM6_HELRO
Uncharacterized protein
Search

0.49	ATP-dependent RNA helicase

0.45	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.45	GO:0010501	RNA secondary structure unwinding
0.44	GO:0051028	mRNA transport
0.44	GO:0000398	mRNA splicing, via spliceosome
0.44	GO:0006405	RNA export from nucleus
0.40	GO:0006974	cellular response to DNA damage stimulus
0.38	GO:0060255	regulation of macromolecule metabolic process
0.37	GO:0008340	determination of adult lifespan
0.36	GO:0009893	positive regulation of metabolic process
0.35	GO:0046784	viral mRNA export from host cell nucleus

0.58	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.43	GO:0008186	RNA-dependent ATPase activity
0.39	GO:0042802	identical protein binding
0.39	GO:0140098	catalytic activity, acting on RNA
0.36	GO:0008134	transcription factor binding
0.35	GO:0043008	ATP-dependent protein binding

0.43	GO:0005681	spliceosomal complex
0.42	GO:0005730	nucleolus
0.41	GO:0016607	nuclear speck
0.36	GO:0005667	transcription factor complex
0.36	GO:0005737	cytoplasm
0.35	GO:0005687	U4 snRNP
0.34	GO:0000346	transcription export complex
0.34	GO:0005688	U6 snRNP
0.30	GO:0016020	membrane

tr|T1EFM7|T1EFM7_HELRO
Uncharacterized protein
Search

ALA1

0.40	Mitochondrial alanyl-tRNA synthetase

0.78	GO:0006419	alanyl-tRNA aminoacylation
0.62	GO:0070127	tRNA aminoacylation for mitochondrial protein translation
0.38	GO:0006400	tRNA modification
0.34	GO:0002181	cytoplasmic translation
0.34	GO:0007018	microtubule-based movement
0.33	GO:0032259	methylation

0.78	GO:0004813	alanine-tRNA ligase activity
0.64	GO:0000049	tRNA binding
0.60	GO:0008270	zinc ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0016597	amino acid binding
0.34	GO:0003777	microtubule motor activity
0.34	GO:0008017	microtubule binding
0.33	GO:0008168	methyltransferase activity

0.49	GO:0005737	cytoplasm
0.45	GO:0043231	intracellular membrane-bounded organelle
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016020	membrane

0.78

EC:6.1.1.7

GO:0004813

tr|T1EFM8|T1EFM8_HELRO
Coronin
Search

0.69

Coronin

0.67	GO:0030036	actin cytoskeleton organization
0.67	GO:0060326	cell chemotaxis
0.64	GO:0001845	phagolysosome assembly
0.61	GO:0051126	negative regulation of actin nucleation
0.61	GO:0050900	leukocyte migration
0.58	GO:0030334	regulation of cell migration
0.58	GO:2000394	positive regulation of lamellipodium morphogenesis
0.58	GO:0071363	cellular response to growth factor stimulus
0.57	GO:1902463	protein localization to cell leading edge
0.56	GO:0120036	plasma membrane bounded cell projection organization

0.74	GO:0051015	actin filament binding
0.54	GO:0042802	identical protein binding
0.54	GO:0071933	Arp2/3 complex binding
0.53	GO:0032036	myosin heavy chain binding
0.52	GO:0043548	phosphatidylinositol 3-kinase binding
0.52	GO:0045296	cadherin binding
0.51	GO:0003785	actin monomer binding
0.50	GO:0008022	protein C-terminus binding
0.44	GO:0046983	protein dimerization activity
0.40	GO:0048365	Rac GTPase binding

0.67	GO:0015629	actin cytoskeleton
0.61	GO:0030027	lamellipodium
0.54	GO:0099513	polymeric cytoskeletal fiber
0.52	GO:0045335	phagocytic vesicle
0.52	GO:0001891	phagocytic cup
0.52	GO:0005829	cytosol
0.51	GO:0001772	immunological synapse
0.51	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0030863	cortical cytoskeleton
0.49	GO:0005769	early endosome

tr|T1EFM9|T1EFM9_HELRO
Uncharacterized protein
Search

0.54	receptor-type tyrosine-protein phosphatase F

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.38	GO:0034164	negative regulation of toll-like receptor 9 signaling pathway
0.38	GO:0048699	generation of neurons
0.38	GO:0032687	negative regulation of interferon-alpha production
0.38	GO:0048468	cell development
0.38	GO:0061000	negative regulation of dendritic spine development
0.38	GO:0032688	negative regulation of interferon-beta production
0.37	GO:0022038	corpus callosum development
0.37	GO:0007155	cell adhesion
0.37	GO:0021766	hippocampus development

0.75	GO:0004725	protein tyrosine phosphatase activity
0.39	GO:0008201	heparin binding
0.38	GO:0035374	chondroitin sulfate binding
0.37	GO:0043395	heparan sulfate proteoglycan binding

0.38	GO:0099146	intrinsic component of postsynaptic density membrane
0.38	GO:0099060	integral component of postsynaptic specialization membrane
0.38	GO:0030285	integral component of synaptic vesicle membrane
0.37	GO:0043204	perikaryon
0.36	GO:0030424	axon
0.36	GO:0030054	cell junction

0.75

GO:0004725

tr|T1EFN0|T1EFN0_HELRO
Uncharacterized protein
Search

EXOSC10

0.83	Exosome component 10

0.64	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.62	GO:0006396	RNA processing
0.52	GO:0071048	nuclear retention of unspliced pre-mRNA at the site of transcription
0.51	GO:0071044	histone mRNA catabolic process
0.50	GO:0071034	CUT catabolic process
0.50	GO:1904872	regulation of telomerase RNA localization to Cajal body
0.50	GO:0032211	negative regulation of telomere maintenance via telomerase
0.50	GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process
0.49	GO:0009048	dosage compensation by inactivation of X chromosome
0.43	GO:0042254	ribosome biogenesis

0.72	GO:0008408	3'-5' exonuclease activity
0.52	GO:1901265	nucleoside phosphate binding
0.51	GO:0003676	nucleic acid binding
0.51	GO:0036094	small molecule binding
0.47	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters
0.37	GO:0052689	carboxylic ester hydrolase activity
0.36	GO:0044877	macromolecular complex binding
0.36	GO:0004674	protein serine/threonine kinase activity
0.34	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.34	GO:0005351	sugar:proton symporter activity

0.81	GO:0000176	nuclear exosome (RNase complex)
0.49	GO:0035327	transcriptionally active chromatin
0.46	GO:0005730	nucleolus
0.43	GO:0005829	cytosol
0.37	GO:0005576	extracellular region
0.35	GO:0005654	nucleoplasm
0.34	GO:0000139	Golgi membrane
0.30	GO:0016021	integral component of membrane

0.47	EC:3.1.13	GO:0016896
0.37	KEGG:R00630	GO:0052689

tr|T1EFN1|T1EFN1_HELRO
Uncharacterized protein
Search

0.89	ATP-dependent RNA helicase WM6

0.45	GO:0010501	RNA secondary structure unwinding
0.45	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.44	GO:0051028	mRNA transport
0.43	GO:0000398	mRNA splicing, via spliceosome
0.43	GO:0006405	RNA export from nucleus
0.40	GO:0006974	cellular response to DNA damage stimulus
0.38	GO:0060255	regulation of macromolecule metabolic process
0.37	GO:0008340	determination of adult lifespan
0.36	GO:0009893	positive regulation of metabolic process
0.35	GO:0046784	viral mRNA export from host cell nucleus

0.58	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.43	GO:0008186	RNA-dependent ATPase activity
0.39	GO:0140098	catalytic activity, acting on RNA
0.39	GO:0042802	identical protein binding
0.35	GO:0008134	transcription factor binding
0.35	GO:0043008	ATP-dependent protein binding

0.43	GO:0005681	spliceosomal complex
0.42	GO:0005730	nucleolus
0.40	GO:0016607	nuclear speck
0.36	GO:0005737	cytoplasm
0.36	GO:0005667	transcription factor complex
0.35	GO:0005687	U4 snRNP
0.34	GO:0000346	transcription export complex
0.34	GO:0005688	U6 snRNP
0.30	GO:0016020	membrane

tr|T1EFN2|T1EFN2_HELRO
Uncharacterized protein
Search

AUH

0.35	Methylglutaconyl-CoA hydratase

0.44	GO:0006635	fatty acid beta-oxidation
0.34	GO:0006552	leucine catabolic process
0.34	GO:0006506	GPI anchor biosynthetic process
0.33	GO:0042357	thiamine diphosphate metabolic process
0.33	GO:0006772	thiamine metabolic process
0.33	GO:0006413	translational initiation
0.33	GO:0072528	pyrimidine-containing compound biosynthetic process
0.33	GO:0044272	sulfur compound biosynthetic process
0.33	GO:0009108	coenzyme biosynthetic process
0.32	GO:0019438	aromatic compound biosynthetic process

0.51	GO:0004300	enoyl-CoA hydratase activity
0.43	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
0.41	GO:0004490	methylglutaconyl-CoA hydratase activity
0.38	GO:0016853	isomerase activity
0.34	GO:0004788	thiamine diphosphokinase activity
0.34	GO:0030975	thiamine binding
0.34	GO:0003730	mRNA 3'-UTR binding
0.33	GO:0003743	translation initiation factor activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0016787	hydrolase activity

0.36	GO:0005739	mitochondrion
0.33	GO:0005777	peroxisome
0.30	GO:0016021	integral component of membrane

0.51	EC:4.2.1.17	GO:0004300
0.41	KEGG:R02085	GO:0004490

tr|T1EFN3|T1EFN3_HELRO
Uncharacterized protein
Search

tr|T1EFN4|T1EFN4_HELRO
Uncharacterized protein
Search

0.10	Seryl tRNA synthetase (Fragment)

0.79	GO:0006434	seryl-tRNA aminoacylation
0.46	GO:0048481	plant ovule development
0.38	GO:0016260	selenocysteine biosynthetic process
0.38	GO:0070127	tRNA aminoacylation for mitochondrial protein translation
0.37	GO:0097056	selenocysteinyl-tRNA(Sec) biosynthetic process
0.34	GO:0009658	chloroplast organization
0.34	GO:0006468	protein phosphorylation
0.34	GO:0007005	mitochondrion organization

0.79	GO:0004828	serine-tRNA ligase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0004672	protein kinase activity
0.33	GO:0016788	hydrolase activity, acting on ester bonds

0.49	GO:0005737	cytoplasm
0.39	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016020	membrane

0.79

EC:6.1.1.11

GO:0004828

tr|T1EFN5|T1EFN5_HELRO
V-type proton ATPase subunit a
Search

0.58	V-type proton ATPase subunit a

0.76	GO:0015991	ATP hydrolysis coupled proton transport
0.44	GO:0051452	intracellular pH reduction
0.44	GO:0007430	terminal branching, open tracheal system
0.43	GO:0097352	autophagosome maturation
0.42	GO:0048749	compound eye development
0.41	GO:0007032	endosome organization
0.40	GO:0009416	response to light stimulus
0.37	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly
0.37	GO:0007165	signal transduction
0.35	GO:0015985	energy coupled proton transport, down electrochemical gradient

0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.41	GO:0036442	proton-exporting ATPase activity
0.41	GO:0009881	photoreceptor activity
0.41	GO:0005516	calmodulin binding
0.39	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
0.37	GO:0051117	ATPase binding
0.34	GO:0004788	thiamine diphosphokinase activity
0.34	GO:0030975	thiamine binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.83	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain
0.42	GO:0008021	synaptic vesicle
0.41	GO:0005769	early endosome
0.37	GO:0016471	vacuolar proton-transporting V-type ATPase complex
0.36	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.34

EC:2.7.6.2

GO:0004788

tr|T1EFN6|T1EFN6_HELRO
Uncharacterized protein
Search

0.10	B-box type zinc finger protein ncl-1

0.48	GO:0055060	asymmetric neuroblast division resulting in ganglion mother cell formation
0.47	GO:0007402	ganglion mother cell fate determination
0.47	GO:1900242	regulation of synaptic vesicle endocytosis
0.47	GO:0014019	neuroblast development
0.47	GO:0007400	neuroblast fate determination
0.46	GO:0007406	negative regulation of neuroblast proliferation
0.45	GO:0008582	regulation of synaptic growth at neuromuscular junction
0.45	GO:0009303	rRNA transcription
0.44	GO:0035282	segmentation
0.44	GO:0007411	axon guidance

0.62	GO:0008270	zinc ion binding
0.45	GO:0030371	translation repressor activity
0.40	GO:0003676	nucleic acid binding
0.33	GO:0005509	calcium ion binding
0.33	GO:0005515	protein binding
0.33	GO:0016874	ligase activity

0.46	GO:0045180	basal cortex
0.46	GO:0045179	apical cortex
0.44	GO:0043025	neuronal cell body
0.34	GO:0016593	Cdc73/Paf1 complex
0.30	GO:0016021	integral component of membrane

0.33

GO:0016874

tr|T1EFN7|T1EFN7_HELRO
Uncharacterized protein
Search

POLR3H

0.89	RNA polymerase III subunit H

0.58	GO:0006351	transcription, DNA-templated
0.44	GO:0061484	hematopoietic stem cell homeostasis
0.36	GO:0045087	innate immune response
0.36	GO:0051607	defense response to virus
0.36	GO:0006399	tRNA metabolic process
0.34	GO:0032481	positive regulation of type I interferon production
0.33	GO:0022900	electron transport chain
0.32	GO:0008380	RNA splicing
0.32	GO:0043043	peptide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process

0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.50	GO:0003677	DNA binding
0.33	GO:0020037	heme binding
0.33	GO:0009055	electron transfer activity
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0046872	metal ion binding

0.52	GO:0005666	DNA-directed RNA polymerase III complex
0.46	GO:0005813	centrosome
0.38	GO:0000790	nuclear chromatin
0.33	GO:0005829	cytosol
0.32	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.70

GO:0003899

tr|T1EFN8|T1EFN8_HELRO
Uncharacterized protein
Search

0.61	FERM, RhoGEF and pleckstrin domain-containing protein 1

0.63	GO:0035023	regulation of Rho protein signal transduction
0.55	GO:0065009	regulation of molecular function
0.36	GO:0016601	Rac protein signal transduction
0.34	GO:0033623	regulation of integrin activation
0.34	GO:0071800	podosome assembly
0.34	GO:0016322	neuron remodeling
0.34	GO:0030316	osteoclast differentiation
0.34	GO:0022405	hair cycle process
0.34	GO:0071526	semaphorin-plexin signaling pathway
0.33	GO:0031532	actin cytoskeleton reorganization

0.65	GO:0008092	cytoskeletal protein binding
0.63	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.34	GO:0048365	Rac GTPase binding

0.69	GO:0005856	cytoskeleton
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

tr|T1EFN9|T1EFN9_HELRO
Uncharacterized protein
Search

FARP2

0.65	FERM, RhoGEF and pleckstrin domain protein 2

0.73	GO:0035023	regulation of Rho protein signal transduction
0.63	GO:0065009	regulation of molecular function
0.40	GO:0048666	neuron development
0.40	GO:0016601	Rac protein signal transduction
0.40	GO:0033623	regulation of integrin activation
0.40	GO:0071800	podosome assembly
0.39	GO:0030316	osteoclast differentiation
0.39	GO:0071695	anatomical structure maturation
0.39	GO:0048469	cell maturation
0.39	GO:0022405	hair cycle process

0.73	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.59	GO:0008092	cytoskeletal protein binding
0.42	GO:0048365	Rac GTPase binding

0.63	GO:0005856	cytoskeleton
0.37	GO:0030425	dendrite
0.37	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.37	GO:0044309	neuron spine
0.37	GO:0030175	filopodium
0.36	GO:0098794	postsynapse
0.35	GO:0030054	cell junction
0.35	GO:0005829	cytosol

tr|T1EFP0|T1EFP0_HELRO
Uncharacterized protein
Search

PITX1

0.73	Pituitary homeobox 1

0.64	GO:0007275	multicellular organism development
0.59	GO:0048625	myoblast fate commitment
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.54	GO:0061448	connective tissue development
0.54	GO:0060322	head development
0.54	GO:0014706	striated muscle tissue development
0.51	GO:0006366	transcription by RNA polymerase II
0.51	GO:1902680	positive regulation of RNA biosynthetic process

0.62	GO:0043565	sequence-specific DNA binding
0.57	GO:0003700	DNA binding transcription factor activity
0.55	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.53	GO:0001085	RNA polymerase II transcription factor binding
0.52	GO:0001012	RNA polymerase II regulatory region DNA binding
0.49	GO:0003690	double-stranded DNA binding
0.32	GO:0015075	ion transmembrane transporter activity

0.61	GO:0005634	nucleus
0.51	GO:0005667	transcription factor complex
0.47	GO:0043233	organelle lumen
0.43	GO:0043232	intracellular non-membrane-bounded organelle
0.42	GO:0044446	intracellular organelle part
0.39	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

tr|T1EFP1|T1EFP1_HELRO
Uncharacterized protein
Search

TTC26

0.61	Intraflagellar transport protein 56

0.59	GO:0042073	intraciliary transport
0.56	GO:0007224	smoothened signaling pathway
0.54	GO:0060271	cilium assembly
0.53	GO:0007286	spermatid development
0.49	GO:0008594	photoreceptor cell morphogenesis
0.44	GO:0039023	pronephric duct morphogenesis
0.43	GO:0035845	photoreceptor cell outer segment organization

0.37

GO:0005515

protein binding

0.77	GO:0005929	cilium
0.57	GO:0030992	intraciliary transport particle B
0.51	GO:0005813	centrosome
0.50	GO:0120038	plasma membrane bounded cell projection part

tr|T1EFP2|T1EFP2_HELRO
Uncharacterized protein
Search

GBE1

0.52	Glycogen branching enzyme

0.77	GO:0005978	glycogen biosynthetic process
0.33	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.33	GO:0006754	ATP biosynthetic process
0.33	GO:0099132	ATP hydrolysis coupled cation transmembrane transport

0.80	GO:0003844	1,4-alpha-glucan branching enzyme activity
0.66	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.52	GO:0043169	cation binding
0.40	GO:0102752	1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)
0.36	GO:0030246	carbohydrate binding
0.34	GO:0005515	protein binding
0.33	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.37	GO:0070062	extracellular exosome
0.33	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)
0.33	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.80

EC:2.4.1.18

GO:0003844

tr|T1EFP3|T1EFP3_HELRO
Importin subunit alpha
Search

KPNA2

0.60	Importin subunit alpha

0.80	GO:0006606	protein import into nucleus
0.36	GO:0046015	regulation of transcription by glucose
0.34	GO:0006886	intracellular protein transport
0.34	GO:0000018	regulation of DNA recombination
0.33	GO:0075733	intracellular transport of virus
0.33	GO:0044068	modulation by symbiont of host cellular process
0.33	GO:0019048	modulation by virus of host morphology or physiology
0.33	GO:0006259	DNA metabolic process

0.83	GO:0061608	nuclear import signal receptor activity
0.70	GO:0008565	protein transporter activity
0.53	GO:0008139	nuclear localization sequence binding
0.46	GO:0042826	histone deacetylase binding
0.38	GO:0070491	repressing transcription factor binding
0.34	GO:0003723	RNA binding

0.61	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.45	GO:0031974	membrane-enclosed lumen
0.42	GO:0012505	endomembrane system
0.41	GO:0044446	intracellular organelle part
0.40	GO:0031975	envelope
0.40	GO:0043234	protein complex
0.33	GO:0044216	other organism cell
0.33	GO:0018995	host
0.30	GO:0016020	membrane

tr|T1EFP4|T1EFP4_HELRO
Uncharacterized protein
Search

COG6

0.89	Component of oligomeric golgi complex 6

0.82	GO:0006891	intra-Golgi vesicle-mediated transport
0.48	GO:0070085	glycosylation
0.36	GO:0015031	protein transport
0.34	GO:0006888	ER to Golgi vesicle-mediated transport
0.32	GO:0019538	protein metabolic process
0.32	GO:0043412	macromolecule modification
0.32	GO:0016310	phosphorylation
0.32	GO:0006355	regulation of transcription, DNA-templated
0.32	GO:0044260	cellular macromolecule metabolic process

0.33	GO:0005515	protein binding
0.33	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0017171	serine hydrolase activity
0.32	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.32	GO:0016301	kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0003677	DNA binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.81	GO:0017119	Golgi transport complex
0.37	GO:0000139	Golgi membrane
0.34	GO:0005802	trans-Golgi network
0.30	GO:0016021	integral component of membrane

0.32

GO:0016773

tr|T1EFP5|T1EFP5_HELRO
Phosphatidylinositol 3-kinase
Search

PIK3C3

0.77	Phosphatidylinositol 3-kinase catalytic subunit type

0.84	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
0.81	GO:0048015	phosphatidylinositol-mediated signaling
0.75	GO:0046854	phosphatidylinositol phosphorylation
0.49	GO:0000045	autophagosome assembly
0.47	GO:0016197	endosomal transport
0.47	GO:0098927	vesicle-mediated transport between endosomal compartments
0.46	GO:0042149	cellular response to glucose starvation
0.45	GO:0030242	autophagy of peroxisome
0.45	GO:0016482	cytosolic transport
0.45	GO:0032465	regulation of cytokinesis

0.84	GO:0016303	1-phosphatidylinositol-3-kinase activity
0.40	GO:0004672	protein kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0005515	protein binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.49	GO:0035032	phosphatidylinositol 3-kinase complex, class III
0.47	GO:0044754	autolysosome
0.46	GO:0005768	endosome
0.46	GO:0030496	midbody
0.45	GO:0045335	phagocytic vesicle
0.44	GO:0000407	phagophore assembly site
0.43	GO:0005777	peroxisome
0.42	GO:0005829	cytosol
0.37	GO:0005628	prospore membrane
0.36	GO:0000329	fungal-type vacuole membrane

0.84	EC:2.7.1.137	GO:0016303
0.84	KEGG:R03362	GO:0016303

tr|T1EFP6|T1EFP6_HELRO
Uncharacterized protein
Search

LOC106173967

0.86	O-acetyl-ADP-ribose deacetylase MACROD1-like isoform X2

0.50	GO:0060701	negative regulation of ribonuclease activity
0.45	GO:0042278	purine nucleoside metabolic process

0.49	GO:0008428	ribonuclease inhibitor activity
0.49	GO:0016787	hydrolase activity
0.43	GO:0001883	purine nucleoside binding

0.30

GO:0031224

intrinsic component of membrane

0.49

GO:0016787

tr|T1EFP7|T1EFP7_HELRO
Uncharacterized protein
Search

0.66	Neurohemerythrin

0.40	GO:0015671	oxygen transport
0.35	GO:0046686	response to cadmium ion
0.32	GO:0007165	signal transduction

0.62	GO:0005506	iron ion binding
0.40	GO:0005344	oxygen carrier activity
0.33	GO:0004871	signal transducer activity

0.32	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

tr|T1EFP8|T1EFP8_HELRO
Uncharacterized protein
Search

0.71	GO:0007035	vacuolar acidification
0.68	GO:0035149	lumen formation, open tracheal system
0.63	GO:0008593	regulation of Notch signaling pathway
0.54	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly
0.35	GO:0030198	extracellular matrix organization
0.34	GO:0007155	cell adhesion
0.33	GO:0043043	peptide biosynthetic process
0.33	GO:0044267	cellular protein metabolic process
0.32	GO:0010467	gene expression
0.32	GO:0009059	macromolecule biosynthetic process

0.34	GO:0005509	calcium ion binding
0.33	GO:0003735	structural constituent of ribosome

0.57	GO:0043291	RAVE complex
0.34	GO:0031012	extracellular matrix
0.33	GO:0005840	ribosome
0.30	GO:0016020	membrane

tr|T1EFP9|T1EFP9_HELRO
Uncharacterized protein
Search

FBXW7

0.87	F-box and WD repeat domain containing 7

0.80	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
0.77	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
0.77	GO:0032876	negative regulation of DNA endoreduplication
0.75	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.74	GO:1903146	regulation of autophagy of mitochondrion
0.73	GO:1903955	positive regulation of protein targeting to mitochondrion
0.72	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
0.72	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.71	GO:0051443	positive regulation of ubiquitin-protein transferase activity
0.69	GO:1901800	positive regulation of proteasomal protein catabolic process

0.79	GO:0050816	phosphothreonine residue binding
0.71	GO:0097027	ubiquitin-protein transferase activator activity
0.71	GO:0030332	cyclin binding
0.69	GO:0030674	protein binding, bridging
0.68	GO:0031625	ubiquitin protein ligase binding
0.64	GO:0042802	identical protein binding
0.41	GO:0004842	ubiquitin-protein transferase activity
0.38	GO:0016905	myosin heavy chain kinase activity
0.36	GO:0061659	ubiquitin-like protein ligase activity
0.36	GO:0003700	DNA binding transcription factor activity

0.79	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex
0.71	GO:0019005	SCF ubiquitin ligase complex
0.45	GO:0005737	cytoplasm
0.41	GO:0005654	nucleoplasm
0.40	GO:0005730	nucleolus
0.37	GO:0012505	endomembrane system
0.37	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.38	EC:2.7.11.7	GO:0016905
0.41	KEGG:R03876	GO:0004842

tr|T1EFQ0|T1EFQ0_HELRO
Uncharacterized protein
Search

0.81	N-ethylmaleimide sensitive fusion protein attachment protein alpha

0.69	GO:0006886	intracellular protein transport
0.56	GO:0035494	SNARE complex disassembly
0.53	GO:0010807	regulation of synaptic vesicle priming
0.51	GO:0035249	synaptic transmission, glutamatergic
0.43	GO:0061025	membrane fusion
0.38	GO:0045176	apical protein localization
0.38	GO:0007420	brain development
0.37	GO:0030182	neuron differentiation
0.36	GO:0043462	regulation of ATPase activity
0.36	GO:0045494	photoreceptor cell maintenance

0.53	GO:0019905	syntaxin binding
0.50	GO:0005483	soluble NSF attachment protein activity
0.35	GO:0032403	protein complex binding
0.33	GO:0004435	phosphatidylinositol phospholipase C activity
0.33	GO:0005509	calcium ion binding
0.32	GO:0004871	signal transducer activity

0.53	GO:0031201	SNARE complex
0.49	GO:0043209	myelin sheath
0.46	GO:0005774	vacuolar membrane
0.36	GO:0070062	extracellular exosome
0.36	GO:0043195	terminal bouton
0.33	GO:0005886	plasma membrane
0.32	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.33	EC:3.1.4.11	GO:0004435
0.33	KEGG:R03435	GO:0004435

tr|T1EFQ1|T1EFQ1_HELRO
Uncharacterized protein
Search

tr|T1EFQ2|T1EFQ2_HELRO
Uncharacterized protein
Search

PSMD2

0.76	26S proteasome non-ATPase regulatory subunit

0.78	GO:0042176	regulation of protein catabolic process
0.69	GO:0050790	regulation of catalytic activity
0.47	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.34	GO:0008063	Toll signaling pathway
0.34	GO:0007623	circadian rhythm

0.70	GO:0030234	enzyme regulator activity
0.40	GO:0004175	endopeptidase activity
0.38	GO:0008270	zinc ion binding
0.33	GO:0008237	metallopeptidase activity
0.33	GO:0005515	protein binding

0.73	GO:1905369	endopeptidase complex
0.60	GO:0043234	protein complex
0.45	GO:0044424	intracellular part
0.37	GO:0043227	membrane-bounded organelle
0.34	GO:0043230	extracellular organelle
0.33	GO:0005615	extracellular space
0.33	GO:0043233	organelle lumen
0.30	GO:0031224	intrinsic component of membrane

tr|T1EFQ3|T1EFQ3_HELRO
Cation-transporting ATPase
Search

0.50	Cation-transporting ATPase

0.60	GO:0006812	cation transport
0.42	GO:0006874	cellular calcium ion homeostasis
0.39	GO:0099131	ATP hydrolysis coupled ion transmembrane transport
0.38	GO:0098660	inorganic ion transmembrane transport

0.61	GO:0016887	ATPase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0046872	metal ion binding
0.42	GO:0015085	calcium ion transmembrane transporter activity
0.40	GO:0022853	active ion transmembrane transporter activity
0.39	GO:0015399	primary active transmembrane transporter activity

0.39	GO:0005887	integral component of plasma membrane
0.36	GO:0043231	intracellular membrane-bounded organelle

0.61

GO:0016887

tr|T1EFQ4|T1EFQ4_HELRO
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
Search

QRSL1

0.71	Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

0.77	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation
0.73	GO:0032543	mitochondrial translation
0.46	GO:0031647	regulation of protein stability
0.44	GO:0030717	karyosome formation

0.76	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
0.75	GO:0004040	amidase activity
0.51	GO:0032559	adenyl ribonucleotide binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0016740	transferase activity
0.32	GO:0003723	RNA binding

0.77	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex
0.57	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

0.76

EC:6.3.5.7

GO:0050567

tr|T1EFQ5|T1EFQ5_HELRO
Uncharacterized protein
Search

0.62	GO:0006413	translational initiation
0.59	GO:0002181	cytoplasmic translation
0.59	GO:0006446	regulation of translational initiation
0.53	GO:0065009	regulation of molecular function
0.34	GO:0034314	Arp2/3 complex-mediated actin nucleation
0.34	GO:0007064	mitotic sister chromatid cohesion
0.33	GO:0009245	lipid A biosynthetic process
0.32	GO:0055114	oxidation-reduction process
0.32	GO:0006334	nucleosome assembly
0.32	GO:0009250	glucan biosynthetic process

0.63	GO:0003743	translation initiation factor activity
0.59	GO:0016779	nucleotidyltransferase activity
0.59	GO:0005085	guanyl-nucleotide exchange factor activity
0.36	GO:0046872	metal ion binding
0.35	GO:0004506	squalene monooxygenase activity
0.33	GO:0050660	flavin adenine dinucleotide binding
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0016410	N-acyltransferase activity
0.32	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
0.31	GO:0030554	adenyl nucleotide binding

0.65	GO:0005851	eukaryotic translation initiation factor 2B complex
0.64	GO:0032045	guanyl-nucleotide exchange factor complex
0.34	GO:0005885	Arp2/3 protein complex
0.34	GO:0031390	Ctf18 RFC-like complex
0.33	GO:0005840	ribosome
0.31	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.59	EC:2.7.7	GO:0016779
0.35	KEGG:R02874	GO:0004506

tr|T1EFQ6|T1EFQ6_HELRO
Uncharacterized protein
Search

COPZ1

0.88	Coatomer protein complex subunit zeta

0.65	GO:0015031	protein transport
0.59	GO:0016192	vesicle-mediated transport
0.59	GO:0046907	intracellular transport
0.59	GO:0034613	cellular protein localization
0.45	GO:1901998	toxin transport
0.39	GO:0002088	lens development in camera-type eye
0.34	GO:0048599	oocyte development
0.34	GO:0009792	embryo development ending in birth or egg hatching
0.32	GO:0006260	DNA replication
0.32	GO:1903506	regulation of nucleic acid-templated transcription

0.33	GO:0043565	sequence-specific DNA binding
0.32	GO:0003723	RNA binding

0.64	GO:0030117	membrane coat
0.46	GO:0030663	COPI-coated vesicle membrane
0.44	GO:0044431	Golgi apparatus part
0.36	GO:0031984	organelle subcompartment
0.34	GO:0030133	transport vesicle
0.33	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.33	GO:0044432	endoplasmic reticulum part
0.33	GO:0005829	cytosol
0.33	GO:0000808	origin recognition complex
0.33	GO:0005634	nucleus

tr|T1EFQ7|T1EFQ7_HELRO
Innexin
Search

INX

0.48

Innexin

0.58	GO:0006811	ion transport
0.43	GO:0006367	transcription initiation from RNA polymerase II promoter
0.38	GO:0051390	inactivation of MAPKKK activity
0.37	GO:0035545	determination of left/right asymmetry in nervous system
0.37	GO:0010496	intercellular transport
0.36	GO:2001258	negative regulation of cation channel activity
0.36	GO:0010644	cell communication by electrical coupling
0.34	GO:0030154	cell differentiation
0.34	GO:0055085	transmembrane transport
0.32	GO:0055114	oxidation-reduction process

0.38	GO:0005243	gap junction channel activity
0.37	GO:0019855	calcium channel inhibitor activity
0.36	GO:0004860	protein kinase inhibitor activity
0.32	GO:0016491	oxidoreductase activity

0.80	GO:0005921	gap junction
0.55	GO:0005886	plasma membrane
0.44	GO:0005669	transcription factor TFIID complex
0.36	GO:0043025	neuronal cell body
0.34	GO:0045202	synapse
0.30	GO:0016021	integral component of membrane

0.32

GO:0016491

tr|T1EFQ8|T1EFQ8_HELRO
Uncharacterized protein
Search

0.31	NADP-dependent oxidoreductase

0.52	GO:0055114	oxidation-reduction process
0.35	GO:0006692	prostanoid metabolic process

0.70	GO:0047522	15-oxoprostaglandin 13-oxidase activity
0.68	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.35	GO:0036132	13-prostaglandin reductase activity
0.35	GO:0003960	NADPH:quinone reductase activity
0.35	GO:0004022	alcohol dehydrogenase (NAD) activity
0.33	GO:0016746	transferase activity, transferring acyl groups

0.43	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.70	EC:1.3.1.48	GO:0047522
0.70	KEGG:R04556 KEGG:R04557	GO:0047522

tr|T1EFQ9|T1EFQ9_HELRO
Uncharacterized protein
Search

SNRNP70

0.81	Small nuclear ribonucleoprotein U1 subunit 70

0.51	GO:0043484	regulation of RNA splicing
0.48	GO:0000398	mRNA splicing, via spliceosome
0.47	GO:0050684	regulation of mRNA processing
0.45	GO:1903313	positive regulation of mRNA metabolic process
0.45	GO:0060218	hematopoietic stem cell differentiation
0.43	GO:0048477	oogenesis
0.42	GO:0007283	spermatogenesis
0.42	GO:0010628	positive regulation of gene expression
0.41	GO:1903312	negative regulation of mRNA metabolic process
0.39	GO:0010629	negative regulation of gene expression

0.84	GO:0030619	U1 snRNA binding
0.47	GO:0003729	mRNA binding
0.40	GO:1990446	U1 snRNP binding
0.33	GO:0005515	protein binding

0.58	GO:0019013	viral nucleocapsid
0.54	GO:0030529	intracellular ribonucleoprotein complex
0.49	GO:0120114	Sm-like protein family complex
0.44	GO:0044428	nuclear part
0.43	GO:0031974	membrane-enclosed lumen
0.33	GO:0005737	cytoplasm
0.33	GO:1902494	catalytic complex
0.30	GO:0016020	membrane

tr|T1EFR0|T1EFR0_HELRO
Nicotinamide-nucleotide adenylyltransferase
Search

NMNAT1

0.61	Nicotinamide-nucleotide adenylyltransferase

0.72	GO:0009435	NAD biosynthetic process
0.45	GO:0019355	nicotinamide nucleotide biosynthetic process from aspartate
0.44	GO:0006351	transcription, DNA-templated
0.39	GO:0009860	pollen tube growth
0.38	GO:0009611	response to wounding
0.38	GO:0009555	pollen development

0.75	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity
0.71	GO:0004515	nicotinate-nucleotide adenylyltransferase activity
0.50	GO:0032559	adenyl ribonucleotide binding
0.50	GO:0008144	drug binding
0.50	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0046983	protein dimerization activity
0.34	GO:0008289	lipid binding
0.32	GO:0003676	nucleic acid binding
0.32	GO:0046872	metal ion binding

0.36	GO:0043231	intracellular membrane-bounded organelle
0.34	GO:0044444	cytoplasmic part

0.75

EC:2.7.7.1

GO:0000309

tr|T1EFR1|T1EFR1_HELRO
Uncharacterized protein
Search

tr|T1EFR2|T1EFR2_HELRO
Uncharacterized protein
Search

ND1

0.24	NADH-ubiquinone oxidoreductase chain 1 (Fragment)

0.53

GO:0055114

oxidation-reduction process

0.69

GO:0008137

NADH dehydrogenase (ubiquinone) activity

0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane
0.30	GO:0031224	intrinsic component of membrane

0.69

EC:1.6.5.3

GO:0008137

tr|T1EFR3|T1EFR3_HELRO
Uncharacterized protein
Search

HNRNPR

0.83	Heterogeneous nuclear ribonucleoprotein Q

0.47	GO:1902284	neuron projection extension involved in neuron projection guidance
0.46	GO:0048675	axon extension
0.45	GO:0007411	axon guidance
0.40	GO:0043488	regulation of mRNA stability
0.39	GO:0050779	RNA destabilization
0.39	GO:0017148	negative regulation of translation
0.39	GO:0061014	positive regulation of mRNA catabolic process
0.38	GO:0007623	circadian rhythm
0.37	GO:0043086	negative regulation of catalytic activity
0.36	GO:0043489	RNA stabilization

0.59	GO:0003723	RNA binding
0.34	GO:0005515	protein binding

0.64	GO:0019013	viral nucleocapsid
0.58	GO:0030529	intracellular ribonucleoprotein complex
0.47	GO:0005654	nucleoplasm
0.44	GO:1902494	catalytic complex
0.39	GO:0043679	axon terminus
0.39	GO:0030426	growth cone
0.38	GO:0030425	dendrite
0.37	GO:0097452	GAIT complex
0.37	GO:0070937	CRD-mediated mRNA stability complex
0.37	GO:0005730	nucleolus

tr|T1EFR4|T1EFR4_HELRO
Polypeptide N-acetylgalactosaminyltransferase
Search

0.63	Polypeptide N-acetylgalactosaminyltransferase

0.71	GO:0006486	protein glycosylation
0.42	GO:0018210	peptidyl-threonine modification
0.41	GO:0018209	peptidyl-serine modification
0.38	GO:0009312	oligosaccharide biosynthetic process
0.35	GO:0001731	formation of translation preinitiation complex
0.35	GO:0006446	regulation of translational initiation
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:2001141	regulation of RNA biosynthetic process

0.67	GO:0030246	carbohydrate binding
0.63	GO:0016757	transferase activity, transferring glycosyl groups
0.39	GO:0030145	manganese ion binding
0.38	GO:0140096	catalytic activity, acting on a protein
0.35	GO:0043022	ribosome binding
0.35	GO:0003743	translation initiation factor activity
0.34	GO:0008270	zinc ion binding

0.71	GO:0000139	Golgi membrane
0.40	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0005795	Golgi stack
0.35	GO:0016282	eukaryotic 43S preinitiation complex
0.35	GO:0033290	eukaryotic 48S preinitiation complex
0.35	GO:0005852	eukaryotic translation initiation factor 3 complex
0.34	GO:0005634	nucleus
0.33	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.63

GO:0016757

tr|T1EFR5|T1EFR5_HELRO
Protein yippee-like
Search

0.16

Yippee 5

0.49

GO:0043312

neutrophil degranulation

0.54

GO:0046872

metal ion binding

0.51	GO:1904724	tertiary granule lumen
0.50	GO:1904813	ficolin-1-rich granule lumen
0.42	GO:0005576	extracellular region

tr|T1EFR6|T1EFR6_HELRO
Uncharacterized protein
Search

ND4L

0.39	NADH-ubiquinone oxidoreductase chain 4L

0.65

GO:0042773

ATP synthesis coupled electron transport

0.64

GO:0008137

NADH dehydrogenase (ubiquinone) activity

0.61	GO:0005739	mitochondrion
0.30	GO:0044425	membrane part

0.64

EC:1.6.5.3

GO:0008137

tr|T1EFR7|T1EFR7_HELRO
Uncharacterized protein
Search

ERI1

0.39	Exonuclease

0.41	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.38	GO:0006259	DNA metabolic process
0.38	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation
0.35	GO:0071044	histone mRNA catabolic process
0.33	GO:0032366	intracellular sterol transport
0.33	GO:0060906	negative regulation of chromatin silencing by small RNA
0.33	GO:0002943	tRNA dihydrouridine synthesis
0.33	GO:0031125	rRNA 3'-end processing
0.33	GO:0006508	proteolysis
0.33	GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

0.51	GO:0003676	nucleic acid binding
0.43	GO:0004527	exonuclease activity
0.39	GO:0008270	zinc ion binding
0.36	GO:0004540	ribonuclease activity
0.36	GO:0004536	deoxyribonuclease activity
0.35	GO:0016772	transferase activity, transferring phosphorus-containing groups
0.33	GO:0008237	metallopeptidase activity
0.33	GO:0017150	tRNA dihydrouridine synthase activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0050660	flavin adenine dinucleotide binding

0.34	GO:0016035	zeta DNA polymerase complex
0.32	GO:0005576	extracellular region
0.32	GO:0005886	plasma membrane
0.31	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.35

EC:2.7

GO:0016772

tr|T1EFR8|T1EFR8_HELRO
Uncharacterized protein
Search

0.46	Zinc transporter

0.62	GO:0006882	cellular zinc ion homeostasis
0.61	GO:0098655	cation transmembrane transport
0.60	GO:0006829	zinc II ion transport
0.49	GO:0098660	inorganic ion transmembrane transport
0.45	GO:0010043	response to zinc ion
0.44	GO:0030073	insulin secretion
0.44	GO:0061088	regulation of sequestering of zinc ion
0.43	GO:0051238	sequestering of metal ion
0.43	GO:0009749	response to glucose
0.38	GO:0097501	stress response to metal ion

0.61	GO:0008324	cation transmembrane transporter activity
0.48	GO:0015318	inorganic molecular entity transmembrane transporter activity
0.39	GO:0042803	protein homodimerization activity
0.37	GO:0031491	nucleosome binding
0.35	GO:0015562	efflux transmembrane transporter activity
0.35	GO:0004386	helicase activity
0.34	GO:0008270	zinc ion binding
0.34	GO:0004862	cAMP-dependent protein kinase inhibitor activity
0.34	GO:0003980	UDP-glucose:glycoprotein glucosyltransferase activity
0.34	GO:0016887	ATPase activity

0.43	GO:0031410	cytoplasmic vesicle
0.40	GO:0012505	endomembrane system
0.39	GO:0005886	plasma membrane
0.37	GO:0016589	NURF complex
0.36	GO:0098805	whole membrane
0.36	GO:0098588	bounding membrane of organelle
0.36	GO:0012506	vesicle membrane
0.36	GO:0045177	apical part of cell
0.34	GO:0005764	lysosome
0.34	GO:0044437	vacuolar part

0.34

GO:0003980

tr|T1EFR9|T1EFR9_HELRO
Uncharacterized protein
Search

0.30	Serine beta-lactamase protein LACTB, mitochondrial

0.48	GO:0019216	regulation of lipid metabolic process
0.42	GO:0006508	proteolysis
0.37	GO:0007229	integrin-mediated signaling pathway
0.36	GO:0006468	protein phosphorylation

0.42	GO:0008233	peptidase activity
0.38	GO:0008800	beta-lactamase activity
0.36	GO:0004672	protein kinase activity
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0097367	carbohydrate derivative binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0005829	cytosol
0.42	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.42

EC:3.4

GO:0008233

tr|T1EFS0|T1EFS0_HELRO
mRNA-capping enzyme
Search

RNGTT

0.86	mRNA-capping enzyme

0.84	GO:0098507	polynucleotide 5' dephosphorylation
0.74	GO:0006370	7-methylguanosine mRNA capping
0.73	GO:0035335	peptidyl-tyrosine dephosphorylation
0.34	GO:0006366	transcription by RNA polymerase II
0.33	GO:0016032	viral process

0.84	GO:0004651	polynucleotide 5'-phosphatase activity
0.82	GO:0004484	mRNA guanylyltransferase activity
0.77	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.73	GO:0004725	protein tyrosine phosphatase activity
0.62	GO:0032550	purine ribonucleoside binding
0.62	GO:0019001	guanyl nucleotide binding
0.56	GO:0050355	triphosphatase activity
0.51	GO:0032555	purine ribonucleotide binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.33	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part

0.84	EC:3.1.3.33	GO:0004651
0.56	KEGG:R00138	GO:0050355

tr|T1EFS1|T1EFS1_HELRO
Uncharacterized protein
Search

0.70	GO:0005783	endoplasmic reticulum
0.30	GO:0044425	membrane part

tr|T1EFS2|T1EFS2_HELRO
Uncharacterized protein
Search

0.40	GO:1903506	regulation of nucleic acid-templated transcription
0.40	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.40	GO:0010468	regulation of gene expression
0.38	GO:0040034	regulation of development, heterochronic
0.36	GO:0045665	negative regulation of neuron differentiation
0.36	GO:0043065	positive regulation of apoptotic process
0.35	GO:0006351	transcription, DNA-templated

0.51	GO:0003676	nucleic acid binding
0.40	GO:0046872	metal ion binding
0.38	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding

0.39

GO:0005634

nucleus

tr|T1EFS3|T1EFS3_HELRO
Uncharacterized protein
Search

0.50	GO:0042254	ribosome biogenesis
0.49	GO:0016072	rRNA metabolic process
0.47	GO:0034470	ncRNA processing
0.47	GO:0071276	cellular response to cadmium ion
0.44	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
0.41	GO:0036211	protein modification process
0.41	GO:0007165	signal transduction
0.40	GO:0016310	phosphorylation
0.40	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
0.39	GO:0030174	regulation of DNA-dependent DNA replication initiation

0.45	GO:0030674	protein binding, bridging
0.41	GO:0016301	kinase activity
0.41	GO:0043531	ADP binding
0.41	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.40	GO:0140096	catalytic activity, acting on a protein
0.39	GO:0043130	ubiquitin binding
0.38	GO:0004402	histone acetyltransferase activity
0.38	GO:0042802	identical protein binding
0.37	GO:0005524	ATP binding
0.37	GO:0003676	nucleic acid binding

0.54	GO:0032040	small-subunit processome
0.46	GO:0019005	SCF ubiquitin ligase complex
0.41	GO:0044428	nuclear part
0.39	GO:0043233	organelle lumen
0.38	GO:0043232	intracellular non-membrane-bounded organelle
0.36	GO:0030686	90S preribosome
0.36	GO:0120114	Sm-like protein family complex
0.35	GO:0099512	supramolecular fiber
0.35	GO:0043234	protein complex
0.33	GO:0005737	cytoplasm

0.41