Queries 6001 to 7000

GO:0005391

sp|P35580|MYH10_HUMAN
Myosin-10
Search

MYH10

0.76	Nonmuscle myosin heavy chain b

0.70	GO:0007018	microtubule-based movement
0.51	GO:0031032	actomyosin structure organization
0.51	GO:0000281	mitotic cytokinesis
0.48	GO:0030048	actin filament-based movement
0.48	GO:0050714	positive regulation of protein secretion
0.47	GO:0021592	fourth ventricle development
0.46	GO:0021678	third ventricle development
0.46	GO:0006930	substrate-dependent cell migration, cell extension
0.46	GO:0001778	plasma membrane repair
0.46	GO:0021670	lateral ventricle development

0.74	GO:0051015	actin filament binding
0.73	GO:0003774	motor activity
0.71	GO:0008017	microtubule binding
0.55	GO:0005524	ATP binding
0.50	GO:0030898	actin-dependent ATPase activity
0.50	GO:0035613	RNA stem-loop binding
0.47	GO:0048027	mRNA 5'-UTR binding
0.45	GO:0043531	ADP binding
0.38	GO:0005516	calmodulin binding
0.34	GO:0042802	identical protein binding

0.77	GO:0016459	myosin complex
0.53	GO:0097517	contractile actin filament bundle
0.52	GO:0042641	actomyosin
0.49	GO:0005938	cell cortex
0.49	GO:0097610	cell surface furrow
0.48	GO:0030496	midbody
0.48	GO:0005844	polysome
0.47	GO:0032155	cell division site part
0.44	GO:0043197	dendritic spine
0.44	GO:0031594	neuromuscular junction

sp|P35590|TIE1_HUMAN
Tyrosine-protein kinase receptor Tie-1
Search

TIE1

0.91	Tyrosine kinase with immunoglobulin like and EGF like domains 1

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.74	GO:0032526	response to retinoic acid
0.73	GO:0045026	plasma membrane fusion
0.72	GO:0016525	negative regulation of angiogenesis
0.71	GO:0030336	negative regulation of cell migration
0.69	GO:0001568	blood vessel development
0.67	GO:0001701	in utero embryonic development

0.77	GO:0004713	protein tyrosine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0005509	calcium ion binding

0.50	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.77

GO:0004713

sp|P35606|COPB2_HUMAN
Coatomer subunit beta'
Search

COPB2

0.63	Coatomer subunit beta'

0.69	GO:0006886	intracellular protein transport
0.69	GO:0016192	vesicle-mediated transport
0.52	GO:1901998	toxin transport
0.47	GO:0030903	notochord development
0.46	GO:0061053	somite development

0.62	GO:0005198	structural molecule activity
0.37	GO:0005080	protein kinase C binding
0.32	GO:0016740	transferase activity

0.75	GO:0030117	membrane coat
0.73	GO:0030663	COPI-coated vesicle membrane
0.67	GO:0000139	Golgi membrane
0.38	GO:0005829	cytosol
0.36	GO:0030133	transport vesicle
0.34	GO:0099503	secretory vesicle
0.34	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016740

sp|P35609|ACTN2_HUMAN
Alpha-actinin-2
Search

ACTN2

0.97	Alpha-actinin-2

0.59	GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway
0.58	GO:0045214	sarcomere organization
0.58	GO:0030035	microspike assembly
0.58	GO:2001137	positive regulation of endocytic recycling
0.57	GO:0048041	focal adhesion assembly
0.57	GO:2000009	negative regulation of protein localization to cell surface
0.57	GO:1901017	negative regulation of potassium ion transmembrane transporter activity
0.56	GO:0014706	striated muscle tissue development
0.56	GO:0051695	actin filament uncapping
0.56	GO:1901018	positive regulation of potassium ion transmembrane transporter activity

0.73	GO:0003779	actin binding
0.69	GO:0005509	calcium ion binding
0.59	GO:0070080	titin Z domain binding
0.58	GO:0030375	thyroid hormone receptor coactivator activity
0.58	GO:0051373	FATZ binding
0.57	GO:0031432	titin binding
0.56	GO:0030274	LIM domain binding
0.55	GO:0044325	ion channel binding
0.54	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.51	GO:0032403	protein complex binding

0.55	GO:0030018	Z disc
0.54	GO:0030175	filopodium
0.53	GO:0005925	focal adhesion
0.41	GO:0005886	plasma membrane
0.37	GO:0005903	brush border
0.37	GO:0030864	cortical actin cytoskeleton
0.36	GO:0005884	actin filament
0.36	GO:0070062	extracellular exosome
0.35	GO:0031093	platelet alpha granule lumen
0.35	GO:0005916	fascia adherens

sp|P35610|SOAT1_HUMAN
Sterol O-acyltransferase 1
Search

SOAT1

0.63	O-acyltransferase

0.73	GO:0034435	cholesterol esterification
0.67	GO:0042632	cholesterol homeostasis
0.59	GO:0034379	very-low-density lipoprotein particle assembly
0.59	GO:0042986	positive regulation of amyloid precursor protein biosynthetic process
0.59	GO:0010878	cholesterol storage
0.58	GO:0008203	cholesterol metabolic process
0.58	GO:0010742	macrophage derived foam cell differentiation
0.57	GO:0033344	cholesterol efflux
0.36	GO:0034383	low-density lipoprotein particle clearance
0.32	GO:0006414	translational elongation

0.75	GO:0034736	cholesterol O-acyltransferase activity
0.55	GO:0015485	cholesterol binding
0.54	GO:0000062	fatty-acyl-CoA binding
0.34	GO:0005201	extracellular matrix structural constituent
0.33	GO:0005515	protein binding
0.32	GO:0003746	translation elongation factor activity

0.66	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0005903	brush border
0.30	GO:0016021	integral component of membrane

0.75	EC:2.3.1.26	GO:0034736
0.75	KEGG:R01461	GO:0034736

sp|P35611|ADDA_HUMAN
Alpha-adducin
Search

ADD1

0.95	Alpha-adducin

0.56	GO:1901552	positive regulation of endothelial cell development
0.56	GO:1903140	regulation of establishment of endothelial barrier
0.55	GO:0020027	hemoglobin metabolic process
0.55	GO:1903393	positive regulation of adherens junction organization
0.54	GO:0048873	homeostasis of number of cells within a tissue
0.54	GO:0071277	cellular response to calcium ion
0.53	GO:0035264	multicellular organism growth
0.53	GO:0030218	erythrocyte differentiation
0.53	GO:0006884	cell volume homeostasis
0.53	GO:0032092	positive regulation of protein binding

0.53	GO:0030507	spectrin binding
0.51	GO:0045296	cadherin binding
0.50	GO:0051015	actin filament binding
0.49	GO:0042803	protein homodimerization activity
0.48	GO:0046982	protein heterodimerization activity
0.48	GO:0008134	transcription factor binding
0.44	GO:0005198	structural molecule activity
0.38	GO:0005516	calmodulin binding
0.35	GO:0042608	T cell receptor binding
0.34	GO:0003723	RNA binding

0.69	GO:0005856	cytoskeleton
0.53	GO:0005913	cell-cell adherens junction
0.50	GO:0016604	nuclear body
0.42	GO:0043234	protein complex
0.41	GO:0005886	plasma membrane
0.38	GO:0005737	cytoplasm
0.36	GO:0005925	focal adhesion
0.35	GO:0043197	dendritic spine
0.35	GO:0014069	postsynaptic density

sp|P35612|ADDB_HUMAN
Beta-adducin
Search

ADD2

0.90	Alpha-adducin

0.64	GO:0050901	leukocyte tethering or rolling
0.63	GO:0032092	positive regulation of protein binding
0.62	GO:0051016	barbed-end actin filament capping
0.62	GO:0051017	actin filament bundle assembly
0.56	GO:0030097	hemopoiesis
0.52	GO:0006461	protein complex assembly
0.42	GO:1903142	positive regulation of establishment of endothelial barrier
0.41	GO:0020027	hemoglobin metabolic process
0.41	GO:1903393	positive regulation of adherens junction organization
0.41	GO:0048873	homeostasis of number of cells within a tissue

0.64	GO:0030507	spectrin binding
0.59	GO:0051015	actin filament binding
0.58	GO:0019901	protein kinase binding
0.57	GO:0042803	protein homodimerization activity
0.57	GO:0046982	protein heterodimerization activity
0.47	GO:0005198	structural molecule activity
0.41	GO:0005516	calmodulin binding
0.40	GO:0045296	cadherin binding
0.38	GO:0008134	transcription factor binding
0.32	GO:0003723	RNA binding

0.69	GO:0005856	cytoskeleton
0.61	GO:0044853	plasma membrane raft
0.56	GO:0014069	postsynaptic density
0.54	GO:0031410	cytoplasmic vesicle
0.48	GO:0043234	protein complex
0.47	GO:0044446	intracellular organelle part
0.40	GO:0005913	cell-cell adherens junction
0.37	GO:0031974	membrane-enclosed lumen
0.36	GO:0005634	nucleus
0.35	GO:0005829	cytosol

sp|P35613|BASI_HUMAN
Basigin
Search

BSG

0.93	LOW QUALITY PROTEIN: basigin

0.41	GO:0072659	protein localization to plasma membrane
0.40	GO:0046697	decidualization
0.40	GO:0007566	embryo implantation
0.40	GO:0051591	response to cAMP
0.40	GO:0042475	odontogenesis of dentin-containing tooth
0.39	GO:0043434	response to peptide hormone
0.39	GO:0046689	response to mercury ion
0.38	GO:0002027	regulation of heart rate
0.37	GO:0022617	extracellular matrix disassembly
0.37	GO:0071804	cellular potassium ion transport

0.50	GO:0045296	cadherin binding
0.42	GO:0005537	mannose binding
0.38	GO:0030552	cAMP binding
0.37	GO:0005249	voltage-gated potassium channel activity
0.36	GO:0004252	serine-type endopeptidase activity
0.35	GO:0008028	monocarboxylic acid transmembrane transporter activity

0.52	GO:0002080	acrosomal membrane
0.43	GO:0042470	melanosome
0.40	GO:0005886	plasma membrane
0.40	GO:0043231	intracellular membrane-bounded organelle
0.39	GO:0045121	membrane raft
0.38	GO:0005925	focal adhesion
0.38	GO:0070062	extracellular exosome
0.35	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.36

GO:0004252

sp|P35625|TIMP3_HUMAN
Metalloproteinase inhibitor 3
Search

TIMP3

0.91	Metalloproteinase inhibitor 3

0.74	GO:0010951	negative regulation of endopeptidase activity
0.56	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway
0.56	GO:0051045	negative regulation of membrane protein ectodomain proteolysis
0.54	GO:1904683	regulation of metalloendopeptidase activity
0.54	GO:1905049	negative regulation of metallopeptidase activity
0.53	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.46	GO:0071310	cellular response to organic substance
0.36	GO:0051593	response to folic acid
0.36	GO:0002576	platelet degranulation
0.36	GO:0043627	response to estrogen

0.84	GO:0008191	metalloendopeptidase inhibitor activity
0.45	GO:0002020	protease binding
0.40	GO:0008270	zinc ion binding
0.35	GO:0098770	FBXO family protein binding

0.65	GO:0005576	extracellular region
0.37	GO:0031089	platelet dense granule lumen
0.35	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P35626|ARBK2_HUMAN
Beta-adrenergic receptor kinase 2
Search

GRK3

0.69	G protein-coupled receptor kinase

0.63	GO:0006468	protein phosphorylation
0.61	GO:0031623	receptor internalization
0.61	GO:0007165	signal transduction
0.52	GO:0003108	negative regulation of the force of heart contraction by chemical signal
0.51	GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
0.51	GO:0045988	negative regulation of striated muscle contraction
0.49	GO:0007507	heart development
0.49	GO:0060048	cardiac muscle contraction
0.48	GO:0018210	peptidyl-threonine modification
0.47	GO:0018209	peptidyl-serine modification

0.85	GO:0004703	G-protein coupled receptor kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0031755	Edg-2 lysophosphatidic acid receptor binding
0.47	GO:0047696	beta-adrenergic receptor kinase activity
0.37	GO:0031694	alpha-2A adrenergic receptor binding
0.35	GO:0031748	D1 dopamine receptor binding
0.34	GO:0008138	protein tyrosine/serine/threonine phosphatase activity

0.37	GO:0005737	cytoplasm
0.37	GO:0120025	plasma membrane bounded cell projection
0.36	GO:0036477	somatodendritic compartment
0.35	GO:0098794	postsynapse
0.35	GO:0005886	plasma membrane
0.35	GO:0044463	cell projection part
0.34	GO:0097223	sperm part
0.34	GO:0098857	membrane microdomain
0.34	GO:0045177	apical part of cell
0.34	GO:0099512	supramolecular fiber

0.85

EC:2.7.11.16

GO:0004703

sp|P35637|FUS_HUMAN
RNA-binding protein FUS
Search

FUS

0.88	RNA-binding protein FUS

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.41	GO:0071277	cellular response to calcium ion
0.40	GO:0048675	axon extension
0.36	GO:0000398	mRNA splicing, via spliceosome
0.35	GO:0030968	endoplasmic reticulum unfolded protein response
0.34	GO:0006508	proteolysis
0.34	GO:0051254	positive regulation of RNA metabolic process
0.34	GO:0010557	positive regulation of macromolecule biosynthetic process

0.59	GO:0003723	RNA binding
0.52	GO:0046872	metal ion binding
0.48	GO:0003713	transcription coactivator activity
0.46	GO:0042802	identical protein binding
0.42	GO:0046965	retinoid X receptor binding
0.42	GO:0035255	ionotropic glutamate receptor binding
0.42	GO:0046966	thyroid hormone receptor binding
0.42	GO:0031489	myosin V binding
0.42	GO:0030331	estrogen receptor binding
0.37	GO:0023027	MHC class I protein binding, via antigen binding groove

0.47	GO:0005654	nucleoplasm
0.43	GO:0044327	dendritic spine head
0.41	GO:0043204	perikaryon
0.41	GO:0005844	polysome
0.40	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0031012	extracellular matrix
0.33	GO:0008290	F-actin capping protein complex
0.30	GO:0031224	intrinsic component of membrane

0.34

EC:1.4.3.3

GO:0003884

sp|P35638|DDIT3_HUMAN
DNA damage-inducible transcript 3 protein
Search

DDIT3

0.97	DNA-damage-inducible transcript 3

0.79	GO:0007050	cell cycle arrest
0.79	GO:0006986	response to unfolded protein
0.78	GO:1990442	intrinsic apoptotic signaling pathway in response to nitrosative stress
0.77	GO:2000016	negative regulation of determination of dorsal identity
0.77	GO:0044324	regulation of transcription involved in anterior/posterior axis specification
0.76	GO:0032792	negative regulation of CREB transcription factor activity
0.75	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
0.75	GO:0001955	blood vessel maturation
0.74	GO:0006983	ER overload response
0.74	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

0.75	GO:0043522	leucine zipper domain binding
0.73	GO:0008140	cAMP response element binding protein binding
0.68	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.67	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.63	GO:0042803	protein homodimerization activity
0.62	GO:0046982	protein heterodimerization activity
0.53	GO:0003714	transcription corepressor activity

0.77	GO:0036488	CHOP-C/EBP complex
0.77	GO:1990617	CHOP-ATF4 complex
0.77	GO:1990622	CHOP-ATF3 complex
0.75	GO:0035976	transcription factor AP-1 complex
0.67	GO:0005770	late endosome
0.61	GO:0032993	protein-DNA complex
0.36	GO:0005654	nucleoplasm
0.36	GO:0005829	cytosol

sp|P35658|NU214_HUMAN
Nuclear pore complex protein Nup214
Search

NUP214

0.82	Nucleoporin 214

0.84	GO:0006611	protein export from nucleus
0.81	GO:0006606	protein import into nucleus
0.80	GO:0046822	regulation of nucleocytoplasmic transport
0.79	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.75	GO:0006405	RNA export from nucleus
0.75	GO:0051028	mRNA transport
0.72	GO:0051726	regulation of cell cycle
0.53	GO:0010467	gene expression
0.44	GO:0000278	mitotic cell cycle

0.85	GO:0005049	nuclear export signal receptor activity
0.80	GO:0005487	structural constituent of nuclear pore
0.63	GO:0008139	nuclear localization sequence binding
0.40	GO:0005515	protein binding

0.87	GO:1990876	cytoplasmic side of nuclear pore
0.78	GO:0005925	focal adhesion
0.64	GO:0044613	nuclear pore central transport channel
0.63	GO:0044615	nuclear pore nuclear basket

sp|P35659|DEK_HUMAN
Protein DEK
Search

DEK

0.97	DEK proto-oncogene

0.85	GO:2000779	regulation of double-strand break repair
0.63	GO:0006338	chromatin remodeling
0.43	GO:0016569	covalent chromatin modification
0.40	GO:0045815	positive regulation of gene expression, epigenetic
0.38	GO:0006366	transcription by RNA polymerase II
0.38	GO:0006357	regulation of transcription by RNA polymerase II
0.38	GO:0019079	viral genome replication
0.36	GO:0006886	intracellular protein transport
0.36	GO:0007165	signal transduction
0.33	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

0.79	GO:0042393	histone binding
0.63	GO:0003682	chromatin binding
0.38	GO:0003677	DNA binding
0.38	GO:0003723	RNA binding
0.33	GO:0004523	RNA-DNA hybrid ribonuclease activity
0.32	GO:0003887	DNA-directed DNA polymerase activity

0.76	GO:0043292	contractile fiber
0.61	GO:0005634	nucleus
0.37	GO:0031974	membrane-enclosed lumen
0.36	GO:0005783	endoplasmic reticulum
0.35	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:3.1.26.4

GO:0004523

sp|P35663|CYLC1_HUMAN
Cylicin-1
Search

CYLC1

0.92

Cylicin-1

0.68	GO:0007010	cytoskeleton organization
0.42	GO:0007283	spermatogenesis
0.40	GO:0030154	cell differentiation
0.40	GO:0007275	multicellular organism development
0.36	GO:0009253	peptidoglycan catabolic process
0.34	GO:0007017	microtubule-based process
0.34	GO:0055114	oxidation-reduction process
0.33	GO:0006839	mitochondrial transport
0.33	GO:0006281	DNA repair
0.33	GO:0006402	mRNA catabolic process

0.74	GO:0005200	structural constituent of cytoskeleton
0.37	GO:0008270	zinc ion binding
0.36	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity
0.34	GO:0016491	oxidoreductase activity
0.34	GO:0005518	collagen binding
0.33	GO:0003777	microtubule motor activity
0.33	GO:0008017	microtubule binding
0.33	GO:0016853	isomerase activity
0.33	GO:0004386	helicase activity
0.32	GO:0003676	nucleic acid binding

0.61	GO:0043159	acrosomal matrix
0.47	GO:0033150	cytoskeletal calyx
0.36	GO:0005634	nucleus
0.35	GO:0009986	cell surface
0.33	GO:0030014	CCR4-NOT complex
0.33	GO:0005874	microtubule
0.32	GO:0005694	chromosome
0.32	GO:0019866	organelle inner membrane
0.32	GO:0031966	mitochondrial membrane
0.30	GO:0031224	intrinsic component of membrane

0.36

EC:3.5.1.28

GO:0008745

sp|P35670|ATP7B_HUMAN
Copper-transporting ATPase 2
Search

0.67	ATPase copper transporting alpha

0.68	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.65	GO:0030001	metal ion transport
0.58	GO:0006878	cellular copper ion homeostasis
0.57	GO:0051208	sequestering of calcium ion
0.54	GO:0006882	cellular zinc ion homeostasis
0.53	GO:0046688	response to copper ion
0.53	GO:0007595	lactation
0.51	GO:0051353	positive regulation of oxidoreductase activity
0.46	GO:0046907	intracellular transport
0.45	GO:0098662	inorganic cation transmembrane transport

0.71	GO:0005507	copper ion binding
0.69	GO:0019829	cation-transporting ATPase activity
0.54	GO:0005375	copper ion transmembrane transporter activity
0.54	GO:0032767	copper-dependent protein binding
0.52	GO:1901265	nucleoside phosphate binding
0.51	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
0.51	GO:0036094	small molecule binding
0.41	GO:0097367	carbohydrate derivative binding
0.41	GO:0008144	drug binding
0.40	GO:0043168	anion binding

0.60	GO:0016323	basolateral plasma membrane
0.59	GO:0005770	late endosome
0.58	GO:0005802	trans-Golgi network
0.58	GO:0048471	perinuclear region of cytoplasm
0.50	GO:0030140	trans-Golgi network transport vesicle
0.49	GO:0000139	Golgi membrane
0.39	GO:0043025	neuronal cell body
0.38	GO:0120025	plasma membrane bounded cell projection
0.37	GO:0005903	brush border
0.37	GO:0016324	apical plasma membrane

0.51

EC:1.97.1

GO:0051353

sp|P35680|HNF1B_HUMAN
Hepatocyte nuclear factor 1-beta
Search

HNF1B

0.95	Hepatocyte nuclear factor 1-beta-A

0.73	GO:0045893	positive regulation of transcription, DNA-templated
0.59	GO:0035565	regulation of pronephros size
0.59	GO:0061296	negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
0.58	GO:0072181	mesonephric duct formation
0.58	GO:1900211	regulation of mesenchymal cell apoptotic process involved in metanephros development
0.58	GO:0039020	pronephric nephron tubule development
0.58	GO:0061017	hepatoblast differentiation
0.57	GO:0072095	regulation of branch elongation involved in ureteric bud branching
0.57	GO:0060677	ureteric bud elongation
0.57	GO:0072217	negative regulation of metanephros development

0.55	GO:0003677	DNA binding
0.54	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.53	GO:0001067	regulatory region nucleic acid binding
0.50	GO:0042803	protein homodimerization activity
0.49	GO:0046982	protein heterodimerization activity
0.38	GO:0032403	protein complex binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005634	nucleus
0.50	GO:0005667	transcription factor complex
0.48	GO:0070013	intracellular organelle lumen
0.43	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

sp|P35711|SOX5_HUMAN
Transcription factor SOX-5
Search

SOX5

0.91	Transcription factor SOX-5

0.47	GO:2000741	positive regulation of mesenchymal stem cell differentiation
0.46	GO:0032332	positive regulation of chondrocyte differentiation
0.46	GO:0055059	asymmetric neuroblast division
0.44	GO:0071560	cellular response to transforming growth factor beta stimulus
0.38	GO:0060164	regulation of timing of neuron differentiation
0.37	GO:0048709	oligodendrocyte differentiation
0.37	GO:0006351	transcription, DNA-templated
0.37	GO:0051216	cartilage development
0.37	GO:0021953	central nervous system neuron differentiation
0.37	GO:0001701	in utero embryonic development

0.55	GO:0003677	DNA binding
0.36	GO:0005515	protein binding
0.36	GO:0001067	regulatory region nucleic acid binding
0.36	GO:0003700	DNA binding transcription factor activity

0.61	GO:0005634	nucleus
0.36	GO:0005667	transcription factor complex
0.34	GO:0044446	intracellular organelle part

sp|P35712|SOX6_HUMAN
Transcription factor SOX-6
Search

SOX6

0.88	Transcription factor SOX-6

0.70	GO:0007275	multicellular organism development
0.65	GO:2000741	positive regulation of mesenchymal stem cell differentiation
0.64	GO:2000726	negative regulation of cardiac muscle cell differentiation
0.63	GO:0032332	positive regulation of chondrocyte differentiation
0.59	GO:0001708	cell fate specification
0.59	GO:0071560	cellular response to transforming growth factor beta stimulus
0.59	GO:0061448	connective tissue development
0.59	GO:0034101	erythrocyte homeostasis
0.58	GO:0014706	striated muscle tissue development
0.58	GO:0042692	muscle cell differentiation

0.58	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.56	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.53	GO:0046982	protein heterodimerization activity

0.61	GO:0005634	nucleus
0.50	GO:0031974	membrane-enclosed lumen
0.45	GO:0044446	intracellular organelle part
0.35	GO:0005667	transcription factor complex
0.30	GO:0031224	intrinsic component of membrane

sp|P35713|SOX18_HUMAN
Transcription factor SOX-18
Search

0.86	SRY-box 18

0.82	GO:0060214	endocardium formation
0.80	GO:0060956	endocardial cell differentiation
0.80	GO:0048866	stem cell fate specification
0.80	GO:0060836	lymphatic endothelial cell differentiation
0.79	GO:0001946	lymphangiogenesis
0.78	GO:0042789	mRNA transcription by RNA polymerase II
0.78	GO:0043534	blood vessel endothelial cell migration
0.78	GO:0061028	establishment of endothelial barrier
0.76	GO:0001570	vasculogenesis
0.75	GO:0072091	regulation of stem cell proliferation

0.72	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.71	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.66	GO:0046982	protein heterodimerization activity

0.68	GO:0044798	nuclear transcription factor complex
0.67	GO:0000790	nuclear chromatin

sp|P35716|SOX11_HUMAN
Transcription factor SOX-11
Search

SOX11

0.87	Transcription factor SOX-11

0.63	GO:0060253	negative regulation of glial cell proliferation
0.61	GO:0072395	signal transduction involved in cell cycle checkpoint
0.61	GO:2000648	positive regulation of stem cell proliferation
0.61	GO:0045669	positive regulation of osteoblast differentiation
0.61	GO:0050672	negative regulation of lymphocyte proliferation
0.60	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
0.58	GO:2001109	regulation of lens epithelial cell proliferation
0.58	GO:0045666	positive regulation of neuron differentiation
0.58	GO:0003357	noradrenergic neuron differentiation
0.58	GO:0014009	glial cell proliferation

0.61	GO:0003700	DNA binding transcription factor activity
0.61	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
0.60	GO:0001158	enhancer sequence-specific DNA binding
0.55	GO:0001105	RNA polymerase II transcription coactivator activity
0.51	GO:0008135	translation factor activity, RNA binding
0.36	GO:0046982	protein heterodimerization activity

0.61	GO:0005634	nucleus
0.41	GO:0005737	cytoplasm
0.36	GO:0005667	transcription factor complex
0.35	GO:0070013	intracellular organelle lumen
0.34	GO:0044446	intracellular organelle part

sp|P35749|MYH11_HUMAN
Myosin-11
Search

MYH11

0.95	Myosin heavy chain 11 smooth muscle isoform

0.73	GO:0007018	microtubule-based movement
0.57	GO:0048739	cardiac muscle fiber development
0.56	GO:0048251	elastic fiber assembly
0.40	GO:0030241	skeletal muscle myosin thick filament assembly
0.40	GO:0034453	microtubule anchoring
0.39	GO:0006939	smooth muscle contraction
0.37	GO:0030860	regulation of polarized epithelial cell differentiation
0.36	GO:0048546	digestive tract morphogenesis
0.36	GO:0060047	heart contraction
0.35	GO:0072593	reactive oxygen species metabolic process

0.75	GO:0051015	actin filament binding
0.74	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.55	GO:0008307	structural constituent of muscle
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0005516	calmodulin binding
0.37	GO:0045159	myosin II binding
0.37	GO:0030898	actin-dependent ATPase activity

0.77	GO:0016459	myosin complex
0.38	GO:0044449	contractile fiber part
0.38	GO:0005815	microtubule organizing center
0.38	GO:0042470	melanosome
0.37	GO:0030016	myofibril
0.35	GO:0097517	contractile actin filament bundle
0.35	GO:0042641	actomyosin
0.35	GO:0005903	brush border
0.35	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol

sp|P35754|GLRX1_HUMAN
Glutaredoxin-1
Search

GLRX

0.42	Thioltransferase

0.68	GO:0045454	cell redox homeostasis
0.61	GO:0022900	electron transport chain
0.55	GO:0045838	positive regulation of membrane potential
0.55	GO:2000651	positive regulation of sodium ion transmembrane transporter activity
0.41	GO:0080058	protein deglutathionylation
0.40	GO:0003147	neural crest cell migration involved in heart formation
0.38	GO:0046688	response to copper ion
0.38	GO:0055070	copper ion homeostasis
0.37	GO:0001944	vasculature development
0.37	GO:0007417	central nervous system development

0.72	GO:0015035	protein disulfide oxidoreductase activity
0.62	GO:0009055	electron transfer activity
0.53	GO:0047485	protein N-terminus binding
0.38	GO:0015038	glutathione disulfide oxidoreductase activity
0.38	GO:0047139	glutathione-homocystine transhydrogenase activity
0.37	GO:0016740	transferase activity
0.36	GO:0019153	protein-disulfide reductase (glutathione) activity
0.35	GO:0051117	ATPase binding
0.31	GO:0003676	nucleic acid binding

0.42	GO:0005634	nucleus
0.42	GO:0005739	mitochondrion
0.37	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.35	GO:0043025	neuronal cell body
0.35	GO:0030425	dendrite
0.35	GO:0031970	organelle envelope lumen
0.30	GO:0031224	intrinsic component of membrane

0.38

EC:1.8.4.1

GO:0047139

sp|P35789|ZNF93_HUMAN
Zinc finger protein 93
Search

0.76	Zinc finger protein 93

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.50	GO:0070895	negative regulation of transposon integration
0.42	GO:1902679	negative regulation of RNA biosynthetic process
0.42	GO:0006351	transcription, DNA-templated

0.53	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.43	GO:0003700	DNA binding transcription factor activity

0.46	GO:0005634	nucleus
0.43	GO:0043233	organelle lumen
0.40	GO:0043232	intracellular non-membrane-bounded organelle
0.40	GO:0044446	intracellular organelle part

sp|P35790|CHKA_HUMAN
Choline kinase alpha
Search

CHKA

0.96	Choline kinase alpha

0.58	GO:0006657	CDP-choline pathway
0.55	GO:0016310	phosphorylation
0.54	GO:0006646	phosphatidylethanolamine biosynthetic process
0.42	GO:1904681	response to 3-methylcholanthrene
0.40	GO:0006580	ethanolamine metabolic process
0.39	GO:0019695	choline metabolic process
0.37	GO:0009636	response to toxic substance
0.35	GO:0006869	lipid transport
0.34	GO:0007165	signal transduction

0.60	GO:0004305	ethanolamine kinase activity
0.60	GO:0004103	choline kinase activity
0.56	GO:0004104	cholinesterase activity
0.52	GO:0042803	protein homodimerization activity
0.42	GO:0008144	drug binding
0.40	GO:0033265	choline binding
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0004871	signal transducer activity

0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.60	EC:2.7.1.82	GO:0004305
0.60	KEGG:R01468	GO:0004305

sp|P35813|PPM1A_HUMAN
Protein phosphatase 1A
Search

0.95	LOW QUALITY PROTEIN: protein phosphatase 1A

0.68	GO:0006470	protein dephosphorylation
0.58	GO:0010991	negative regulation of SMAD protein complex assembly
0.57	GO:0042347	negative regulation of NF-kappaB import into nucleus
0.55	GO:0006499	N-terminal protein myristoylation
0.55	GO:0046827	positive regulation of protein export from nucleus
0.55	GO:0030514	negative regulation of BMP signaling pathway
0.54	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.54	GO:0030177	positive regulation of Wnt signaling pathway
0.53	GO:0071560	cellular response to transforming growth factor beta stimulus
0.51	GO:0016055	Wnt signaling pathway

0.73	GO:0004722	protein serine/threonine phosphatase activity
0.68	GO:0030145	manganese ion binding
0.61	GO:0000287	magnesium ion binding
0.57	GO:0070412	R-SMAD binding
0.36	GO:0004871	signal transducer activity
0.35	GO:0008022	protein C-terminus binding
0.32	GO:0003677	DNA binding

0.48	GO:0005829	cytosol
0.45	GO:0005634	nucleus
0.42	GO:0005886	plasma membrane
0.34	GO:0034704	calcium channel complex
0.34	GO:0043005	neuron projection
0.33	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part

sp|P35858|ALS_HUMAN
Insulin-like growth factor-binding protein complex acid labile subunit
Search

IGFALS

0.88	Insulin like growth factor binding protein acid labile subunit

0.46	GO:0007155	cell adhesion
0.42	GO:0010033	response to organic substance
0.42	GO:0051239	regulation of multicellular organismal process
0.42	GO:0034150	toll-like receptor 6 signaling pathway
0.41	GO:0042088	T-helper 1 type immune response
0.41	GO:0016045	detection of bacterium
0.41	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
0.40	GO:0022038	corpus callosum development
0.40	GO:0002755	MyD88-dependent toll-like receptor signaling pathway
0.40	GO:0097327	response to antineoplastic agent

0.64	GO:0005520	insulin-like growth factor binding
0.41	GO:0035374	chondroitin sulfate binding
0.41	GO:0004416	hydroxyacylglutathione hydrolase activity
0.40	GO:0008022	protein C-terminus binding
0.39	GO:0004872	receptor activity
0.39	GO:0008201	heparin binding
0.37	GO:0004860	protein kinase inhibitor activity
0.37	GO:0004871	signal transducer activity
0.35	GO:0001530	lipopolysaccharide binding
0.35	GO:0035663	Toll-like receptor 2 binding

0.84	GO:0042567	insulin-like growth factor ternary complex
0.62	GO:0005654	nucleoplasm
0.44	GO:0070062	extracellular exosome
0.39	GO:0046658	anchored component of plasma membrane
0.38	GO:0009986	cell surface
0.36	GO:0043235	receptor complex
0.35	GO:0098857	membrane microdomain
0.34	GO:0012505	endomembrane system
0.33	GO:0005737	cytoplasm
0.33	GO:0043204	perikaryon

0.41

EC:3.1.2.6

GO:0004416

sp|P35869|AHR_HUMAN
Aryl hydrocarbon receptor
Search

AHR

0.74	Aryl hydrocarbon receptor

0.79	GO:0030522	intracellular receptor signaling pathway
0.76	GO:0009410	response to xenobiotic stimulus
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0006351	transcription, DNA-templated
0.54	GO:0014070	response to organic cyclic compound
0.52	GO:1902680	positive regulation of RNA biosynthetic process
0.46	GO:0007623	circadian rhythm
0.46	GO:0030888	regulation of B cell proliferation

0.85	GO:0004874	aryl hydrocarbon receptor activity
0.65	GO:0046983	protein dimerization activity
0.61	GO:0003700	DNA binding transcription factor activity
0.49	GO:0003677	DNA binding
0.47	GO:0001094	TFIID-class transcription factor binding
0.47	GO:0001223	transcription coactivator binding
0.46	GO:0051879	Hsp90 protein binding
0.45	GO:0001067	regulatory region nucleic acid binding
0.44	GO:0017025	TBP-class protein binding
0.38	GO:0043425	bHLH transcription factor binding

0.85	GO:0034751	aryl hydrocarbon receptor complex
0.59	GO:0005634	nucleus
0.45	GO:0005667	transcription factor complex
0.40	GO:0005737	cytoplasm
0.36	GO:0044446	intracellular organelle part
0.35	GO:0070013	intracellular organelle lumen
0.30	GO:0016020	membrane

sp|P35900|K1C20_HUMAN
Keratin, type I cytoskeletal 20
Search

KRT20

0.83	Keratin, type I cytoskeletal 20

0.56	GO:0045109	intermediate filament organization
0.51	GO:0050708	regulation of protein secretion
0.51	GO:0009267	cellular response to starvation
0.43	GO:0045682	regulation of epidermis development
0.42	GO:0030856	regulation of epithelial cell differentiation
0.40	GO:0031424	keratinization
0.39	GO:0012501	programmed cell death
0.38	GO:0009653	anatomical structure morphogenesis
0.38	GO:0042633	hair cycle
0.37	GO:0001667	ameboidal-type cell migration

0.62	GO:0005198	structural molecule activity
0.38	GO:0005515	protein binding
0.37	GO:0032395	MHC class II receptor activity
0.33	GO:0044877	macromolecular complex binding

0.79	GO:0005882	intermediate filament
0.46	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.34	GO:1990357	terminal web
0.34	GO:0043034	costamere
0.34	GO:0016327	apicolateral plasma membrane
0.34	GO:0045178	basal part of cell
0.34	GO:0042383	sarcolemma
0.34	GO:0030018	Z disc
0.33	GO:0005634	nucleus

sp|P35908|K22E_HUMAN
Keratin, type II cytoskeletal 2 epidermal
Search

0.95	Keratin, type II cytoskeletal 2 epidermal

0.57	GO:0043588	skin development
0.53	GO:0018149	peptide cross-linking
0.53	GO:0008544	epidermis development
0.52	GO:0032980	keratinocyte activation
0.51	GO:0045104	intermediate filament cytoskeleton organization
0.51	GO:0051546	keratinocyte migration
0.50	GO:0043616	keratinocyte proliferation
0.48	GO:0030855	epithelial cell differentiation
0.46	GO:0001867	complement activation, lectin pathway
0.45	GO:0033561	regulation of water loss via skin

0.62	GO:0005198	structural molecule activity
0.43	GO:0008092	cytoskeletal protein binding
0.41	GO:0030246	carbohydrate binding
0.37	GO:0097110	scaffold protein binding
0.33	GO:1990254	keratin filament binding
0.33	GO:0004872	receptor activity

0.83	GO:0045095	keratin filament
0.54	GO:0001533	cornified envelope
0.41	GO:0070062	extracellular exosome
0.37	GO:0005829	cytosol
0.37	GO:0072562	blood microparticle
0.36	GO:0005634	nucleus
0.35	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0031012	extracellular matrix
0.33	GO:0005739	mitochondrion

sp|P35913|PDE6B_HUMAN
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Search

PDE6B

0.54	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

0.61	GO:0007165	signal transduction
0.58	GO:0051480	regulation of cytosolic calcium ion concentration
0.56	GO:0007601	visual perception
0.55	GO:0046037	GMP metabolic process
0.49	GO:0060041	retina development in camera-type eye
0.47	GO:0009583	detection of light stimulus
0.37	GO:0022400	regulation of rhodopsin mediated signaling pathway
0.36	GO:0045494	photoreceptor cell maintenance
0.36	GO:0071482	cellular response to light stimulus
0.36	GO:0198738	cell-cell signaling by wnt

0.80	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.54	GO:0046872	metal ion binding

0.50	GO:0001750	photoreceptor outer segment
0.39	GO:0060170	ciliary membrane

0.80

GO:0004114

sp|P35914|HMGCL_HUMAN
Hydroxymethylglutaryl-CoA lyase, mitochondrial
Search

HMGCL

0.47	Hydroxymethylglutaryl-CoA lyase

0.66	GO:0046951	ketone body biosynthetic process
0.51	GO:0051262	protein tetramerization
0.49	GO:0007005	mitochondrion organization
0.44	GO:0006629	lipid metabolic process
0.38	GO:0070542	response to fatty acid
0.38	GO:0001889	liver development
0.38	GO:0007584	response to nutrient
0.37	GO:0042594	response to starvation
0.36	GO:0035383	thioester metabolic process
0.36	GO:0006012	galactose metabolic process

0.81	GO:0004419	hydroxymethylglutaryl-CoA lyase activity
0.49	GO:0042803	protein homodimerization activity
0.48	GO:0030145	manganese ion binding
0.48	GO:0005102	receptor binding
0.45	GO:0000287	magnesium ion binding
0.37	GO:0000062	fatty-acyl-CoA binding
0.37	GO:0003978	UDP-glucose 4-epimerase activity
0.36	GO:0005092	GDP-dissociation inhibitor activity
0.36	GO:0043177	organic acid binding
0.35	GO:0004560	alpha-L-fucosidase activity

0.51	GO:0005777	peroxisome
0.46	GO:0005739	mitochondrion
0.44	GO:0019866	organelle inner membrane
0.37	GO:0031974	membrane-enclosed lumen
0.36	GO:0005829	cytosol
0.34	GO:0048471	perinuclear region of cytoplasm
0.33	GO:0005783	endoplasmic reticulum

0.81	EC:4.1.3.4	GO:0004419
0.81	KEGG:R01360	GO:0004419

sp|P35916|VGFR3_HUMAN
Vascular endothelial growth factor receptor 3
Search

FLT4

0.95	Fms related tyrosine kinase 4

0.85	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.85	GO:0038084	vascular endothelial growth factor signaling pathway
0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.66	GO:0001946	lymphangiogenesis
0.65	GO:0090037	positive regulation of protein kinase C signaling
0.64	GO:0010575	positive regulation of vascular endothelial growth factor production
0.63	GO:0060312	regulation of blood vessel remodeling
0.63	GO:0001938	positive regulation of endothelial cell proliferation
0.62	GO:0010595	positive regulation of endothelial cell migration
0.62	GO:0003016	respiratory system process

0.85	GO:0005021	vascular endothelial growth factor-activated receptor activity
0.61	GO:0019903	protein phosphatase binding
0.61	GO:0019838	growth factor binding
0.56	GO:0042803	protein homodimerization activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0036332	placental growth factor-activated receptor activity

0.67	GO:0005887	integral component of plasma membrane
0.59	GO:0043235	receptor complex
0.53	GO:0005654	nucleoplasm
0.34	GO:0015629	actin cytoskeleton

sp|P35968|VGFR2_HUMAN
Vascular endothelial growth factor receptor 2
Search

KDR

0.58	Vascular endothelial growth factor receptor

0.85	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.85	GO:0038084	vascular endothelial growth factor signaling pathway
0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.66	GO:1904881	cellular response to hydrogen sulfide
0.64	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
0.64	GO:0051901	positive regulation of mitochondrial depolarization
0.63	GO:2001028	positive regulation of endothelial cell chemotaxis
0.63	GO:0090141	positive regulation of mitochondrial fission
0.63	GO:0050927	positive regulation of positive chemotaxis
0.63	GO:0051894	positive regulation of focal adhesion assembly

0.85	GO:0005021	vascular endothelial growth factor-activated receptor activity
0.81	GO:0019838	growth factor binding
0.60	GO:0005178	integrin binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0042802	identical protein binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.36	GO:0051879	Hsp90 protein binding
0.36	GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity

0.58	GO:0098857	membrane microdomain
0.56	GO:0005768	endosome
0.53	GO:0005794	Golgi apparatus
0.53	GO:0005783	endoplasmic reticulum
0.51	GO:0005887	integral component of plasma membrane
0.39	GO:0030054	cell junction
0.37	GO:0009897	external side of plasma membrane
0.36	GO:0005634	nucleus
0.35	GO:0005576	extracellular region
0.35	GO:0043025	neuronal cell body

0.36

GO:0004716

sp|P35998|PRS7_HUMAN
26S protease regulatory subunit 7
Search

PSMC2

0.82	26S proteasome regulatory subunit 7

0.78	GO:1901800	positive regulation of proteasomal protein catabolic process
0.67	GO:0030163	protein catabolic process
0.55	GO:0006508	proteolysis
0.51	GO:0043632	modification-dependent macromolecule catabolic process
0.47	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
0.45	GO:0034976	response to endoplasmic reticulum stress
0.45	GO:0010243	response to organonitrogen compound
0.43	GO:0044267	cellular protein metabolic process
0.37	GO:0001649	osteoblast differentiation
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition

0.79	GO:0036402	proteasome-activating ATPase activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0008233	peptidase activity
0.46	GO:0017025	TBP-class protein binding
0.32	GO:0046872	metal ion binding

0.57	GO:1905369	endopeptidase complex
0.53	GO:0036464	cytoplasmic ribonucleoprotein granule
0.49	GO:0005829	cytosol
0.48	GO:0043234	protein complex
0.42	GO:0031981	nuclear lumen
0.35	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0034774	secretory granule lumen
0.35	GO:0043197	dendritic spine
0.33	GO:0005576	extracellular region
0.30	GO:0016020	membrane

0.50

GO:0008233

sp|P36021|MOT8_HUMAN
Monocarboxylate transporter 8
Search

SLC16A2

0.97	Solute carrier family 16 (Monocarboxylic acid transporters), member 2

0.86	GO:0070327	thyroid hormone transport
0.55	GO:0055085	transmembrane transport
0.51	GO:0046942	carboxylic acid transport
0.42	GO:0071705	nitrogen compound transport
0.37	GO:0021529	spinal cord oligodendrocyte cell differentiation
0.37	GO:0030878	thyroid gland development
0.37	GO:0014037	Schwann cell differentiation
0.36	GO:0043009	chordate embryonic development
0.36	GO:0007420	brain development
0.35	GO:0030182	neuron differentiation

0.86	GO:0015349	thyroid hormone transmembrane transporter activity
0.53	GO:0046943	carboxylic acid transmembrane transporter activity
0.37	GO:0070324	thyroid hormone binding

0.67

GO:0005887

integral component of plasma membrane

sp|P36222|CH3L1_HUMAN
Chitinase-3-like protein 1
Search

CHI3L1

0.46	Acidic mammalian chitinase

0.65	GO:0045766	positive regulation of angiogenesis
0.63	GO:0006030	chitin metabolic process
0.60	GO:0072606	interleukin-8 secretion
0.60	GO:0005975	carbohydrate metabolic process
0.58	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
0.58	GO:0007250	activation of NF-kappaB-inducing kinase activity
0.58	GO:0070741	response to interleukin-6
0.57	GO:0051897	positive regulation of protein kinase B signaling
0.57	GO:0070555	response to interleukin-1
0.56	GO:0034612	response to tumor necrosis factor

0.77	GO:0008061	chitin binding
0.56	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.40	GO:0030246	carbohydrate binding
0.35	GO:0005201	extracellular matrix structural constituent
0.35	GO:0019900	kinase binding

0.65	GO:0005576	extracellular region
0.50	GO:0005783	endoplasmic reticulum
0.42	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0031982	vesicle
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.56

EC:3.2.1

GO:0004553

sp|P36268|GGT2_HUMAN
Inactive gamma-glutamyltranspeptidase 2
Search

GGT1

0.70	Glutathione hydrolase 1 proenzyme

0.79	GO:0006751	glutathione catabolic process
0.61	GO:0006508	proteolysis
0.50	GO:0050727	regulation of inflammatory response
0.50	GO:0006750	glutathione biosynthetic process
0.50	GO:0007283	spermatogenesis
0.48	GO:0019344	cysteine biosynthetic process
0.46	GO:0002682	regulation of immune system process
0.45	GO:1901748	leukotriene D4 metabolic process
0.44	GO:0019370	leukotriene biosynthetic process
0.39	GO:0051604	protein maturation

0.80	GO:0036374	glutathione hydrolase activity
0.41	GO:0103068	leukotriene C4 gamma-glutamyl transferase activity
0.41	GO:0102953	hypoglycin A gamma-glutamyl transpeptidase activity
0.41	GO:0002951	leukotriene-C(4) hydrolase
0.40	GO:0000048	peptidyltransferase activity
0.33	GO:0005515	protein binding

0.48	GO:0031982	vesicle
0.41	GO:0043230	extracellular organelle
0.39	GO:0005615	extracellular space
0.35	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0005886	plasma membrane
0.34	GO:0005783	endoplasmic reticulum
0.30	GO:0016021	integral component of membrane

0.80	EC:3.4.19.13	GO:0036374
0.80	KEGG:R00494	GO:0036374

sp|P36269|GGT5_HUMAN
Gamma-glutamyltransferase 5
Search

GGT5

0.97	LOW QUALITY PROTEIN: gamma-glutamyltransferase 5

0.79	GO:0006751	glutathione catabolic process
0.62	GO:1901750	leukotriene D4 biosynthetic process
0.61	GO:0006508	proteolysis
0.52	GO:0006954	inflammatory response
0.46	GO:0006631	fatty acid metabolic process
0.42	GO:0006412	translation
0.42	GO:0006520	cellular amino acid metabolic process
0.40	GO:0006750	glutathione biosynthetic process
0.35	GO:0050727	regulation of inflammatory response
0.35	GO:0007283	spermatogenesis

0.80	GO:0036374	glutathione hydrolase activity
0.57	GO:0002951	leukotriene-C(4) hydrolase
0.57	GO:0000048	peptidyltransferase activity
0.41	GO:0103068	leukotriene C4 gamma-glutamyl transferase activity
0.41	GO:0102953	hypoglycin A gamma-glutamyl transpeptidase activity

0.45	GO:0031226	intrinsic component of plasma membrane
0.34	GO:0031982	vesicle
0.33	GO:0043230	extracellular organelle
0.33	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane

0.80	EC:3.4.19.13	GO:0036374
0.80	KEGG:R00494	GO:0036374

sp|P36382|CXA5_HUMAN
Gap junction alpha-5 protein
Search

GJA5

0.65	Gap junction alpha-5 protein (Fragment)

0.64	GO:0086044	atrial cardiac muscle cell to AV node cell communication by electrical coupling
0.64	GO:0098906	regulation of Purkinje myocyte action potential
0.64	GO:0086054	bundle of His cell to Purkinje myocyte communication by electrical coupling
0.64	GO:0098905	regulation of bundle of His cell action potential
0.64	GO:0098904	regulation of AV node cell action potential
0.63	GO:0086053	AV node cell to bundle of His cell communication by electrical coupling
0.63	GO:0003193	pulmonary valve formation
0.62	GO:0098910	regulation of atrial cardiac muscle cell action potential
0.62	GO:0016264	gap junction assembly
0.62	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization

0.65	GO:0005243	gap junction channel activity
0.41	GO:0071253	connexin binding
0.41	GO:0097718	disordered domain specific binding

0.83	GO:0005922	connexin complex
0.59	GO:0014704	intercalated disc
0.49	GO:0005887	integral component of plasma membrane
0.37	GO:0042995	cell projection

sp|P36383|CXG1_HUMAN
Gap junction gamma-1 protein
Search

GJC1

0.64	Gap junction gamma-1 protein (Fragment)

0.61	GO:0086053	AV node cell to bundle of His cell communication by electrical coupling
0.61	GO:0016264	gap junction assembly
0.57	GO:0001570	vasculogenesis
0.56	GO:0048738	cardiac muscle tissue development
0.54	GO:0007601	visual perception
0.53	GO:0007268	chemical synaptic transmission
0.52	GO:0048468	cell development
0.45	GO:0034220	ion transmembrane transport
0.37	GO:0086021	SA node cell to atrial cardiac muscle cell communication by electrical coupling
0.36	GO:0009636	response to toxic substance

0.61	GO:1903763	gap junction channel activity involved in cell communication by electrical coupling
0.50	GO:0005216	ion channel activity
0.33	GO:0005515	protein binding

0.83	GO:0005922	connexin complex
0.38	GO:0043209	myelin sheath
0.36	GO:0014704	intercalated disc
0.34	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

sp|P36402|TCF7_HUMAN
Transcription factor 7
Search

TCF7

0.88	HMG-box transcription factor Tcf-1

0.84	GO:0002681	somatic recombination of T cell receptor gene segments
0.81	GO:0060070	canonical Wnt signaling pathway
0.73	GO:0033151	V(D)J recombination
0.69	GO:0006357	regulation of transcription by RNA polymerase II
0.54	GO:0071353	cellular response to interleukin-4
0.52	GO:0030538	embryonic genitalia morphogenesis
0.51	GO:0048546	digestive tract morphogenesis
0.50	GO:0061525	hindgut development
0.50	GO:0048566	embryonic digestive tract development
0.50	GO:0046632	alpha-beta T cell differentiation

0.81	GO:0008013	beta-catenin binding
0.54	GO:0003677	DNA binding
0.51	GO:0001067	regulatory region nucleic acid binding
0.48	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.49	GO:0000791	euchromatin
0.47	GO:0043233	organelle lumen
0.44	GO:0005667	transcription factor complex
0.30	GO:0016020	membrane

sp|P36404|ARL2_HUMAN
ADP-ribosylation factor-like protein 2
Search

ARL2

0.82	ADP ribosylation factor like GTPase 2

0.47	GO:0051457	maintenance of protein location in nucleus
0.47	GO:0034260	negative regulation of GTPase activity
0.47	GO:0031116	positive regulation of microtubule polymerization
0.45	GO:0007098	centrosome cycle
0.40	GO:0045196	establishment or maintenance of neuroblast polarity
0.39	GO:0070830	bicellular tight junction assembly
0.39	GO:0000132	establishment of mitotic spindle orientation
0.39	GO:0010811	positive regulation of cell-substrate adhesion
0.35	GO:0010817	regulation of hormone levels
0.35	GO:1901374	acetate ester transport

0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0003924	GTPase activity
0.35	GO:0005515	protein binding
0.35	GO:0005095	GTPase inhibitor activity
0.34	GO:0003743	translation initiation factor activity
0.32	GO:0016491	oxidoreductase activity

0.45	GO:0005925	focal adhesion
0.45	GO:0005622	intracellular
0.41	GO:0012505	endomembrane system
0.41	GO:0031974	membrane-enclosed lumen
0.39	GO:0016328	lateral plasma membrane
0.39	GO:0031975	envelope
0.39	GO:0043228	non-membrane-bounded organelle
0.38	GO:0044422	organelle part
0.38	GO:0043227	membrane-bounded organelle
0.36	GO:0043230	extracellular organelle

0.32

GO:0016491

sp|P36405|ARL3_HUMAN
ADP-ribosylation factor-like protein 3
Search

ARL3

0.93	ADP ribosylation factor like GTPase 3

0.54	GO:0042461	photoreceptor cell development
0.53	GO:0000281	mitotic cytokinesis
0.53	GO:0001822	kidney development
0.53	GO:0060271	cilium assembly
0.52	GO:0042073	intraciliary transport
0.52	GO:0007224	smoothened signaling pathway
0.52	GO:0006892	post-Golgi vesicle-mediated transport
0.51	GO:0007264	small GTPase mediated signal transduction
0.38	GO:0048841	regulation of axon extension involved in axon guidance
0.36	GO:0071632	optomotor response

0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0008017	microtubule binding
0.47	GO:0003924	GTPase activity
0.34	GO:0046872	metal ion binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0008144	drug binding

0.56	GO:0032391	photoreceptor connecting cilium
0.54	GO:0005881	cytoplasmic microtubule
0.54	GO:0030496	midbody
0.54	GO:0005876	spindle microtubule
0.52	GO:0005813	centrosome
0.51	GO:0036064	ciliary basal body
0.51	GO:0005930	axoneme
0.49	GO:0005794	Golgi apparatus
0.44	GO:0005634	nucleus
0.39	GO:0098588	bounding membrane of organelle

sp|P36406|TRI23_HUMAN
E3 ubiquitin-protein ligase TRIM23
Search

TRIM23

0.53	GTP-binding protein ARD-1

0.50	GO:0016567	protein ubiquitination
0.35	GO:0006471	protein ADP-ribosylation
0.34	GO:0045087	innate immune response
0.34	GO:0043085	positive regulation of catalytic activity
0.33	GO:0016032	viral process
0.33	GO:0010898	positive regulation of triglyceride catabolic process
0.32	GO:0016042	lipid catabolic process

0.65	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.62	GO:0008270	zinc ion binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0042802	identical protein binding
0.50	GO:0016874	ligase activity
0.50	GO:0004842	ubiquitin-protein transferase activity
0.49	GO:0003676	nucleic acid binding
0.48	GO:0003924	GTPase activity

0.54	GO:0005765	lysosomal membrane
0.51	GO:0000139	Golgi membrane
0.45	GO:0005634	nucleus
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.50	EC:6	GO:0016874
0.50	KEGG:R03876	GO:0004842

sp|P36507|MP2K2_HUMAN
Dual specificity mitogen-activated protein kinase kinase 2
Search

MAP2K2

0.91	Dual specificity mitogen-activated protein kinase kinase 2

0.63	GO:0006468	protein phosphorylation
0.57	GO:0060502	epithelial cell proliferation involved in lung morphogenesis
0.56	GO:0060440	trachea formation
0.55	GO:0030878	thyroid gland development
0.54	GO:0048679	regulation of axon regeneration
0.54	GO:0048538	thymus development
0.54	GO:0060324	face development
0.54	GO:0050772	positive regulation of axonogenesis
0.51	GO:0001932	regulation of protein phosphorylation
0.51	GO:0007507	heart development

0.68	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0032947	protein complex scaffold activity
0.48	GO:0004708	MAP kinase kinase activity
0.48	GO:0097110	scaffold protein binding
0.47	GO:0043539	protein serine/threonine kinase activator activity
0.43	GO:0030165	PDZ domain binding

0.42	GO:0005783	endoplasmic reticulum
0.42	GO:0048471	perinuclear region of cytoplasm
0.41	GO:0030054	cell junction
0.41	GO:0009898	cytoplasmic side of plasma membrane
0.41	GO:0015630	microtubule cytoskeleton
0.40	GO:0005794	Golgi apparatus
0.40	GO:0044430	cytoskeletal part
0.40	GO:0099512	supramolecular fiber
0.39	GO:0005829	cytosol
0.38	GO:0005770	late endosome

0.68

GO:0004674

sp|P36508|ZNF76_HUMAN
Zinc finger protein 76
Search

ZNF76

0.85	LOW QUALITY PROTEIN: zinc finger protein 76

0.54	GO:0006366	transcription by RNA polymerase II
0.54	GO:0045944	positive regulation of transcription by RNA polymerase II
0.33	GO:0009301	snRNA transcription
0.33	GO:0006359	regulation of transcription by RNA polymerase III
0.32	GO:0006383	transcription by RNA polymerase III
0.32	GO:0006468	protein phosphorylation

0.57	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.51	GO:0003676	nucleic acid binding
0.40	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0005515	protein binding
0.35	GO:0046872	metal ion binding
0.32	GO:0004672	protein kinase activity
0.31	GO:0030554	adenyl nucleotide binding
0.31	GO:0032555	purine ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.36	GO:0005634	nucleus
0.32	GO:0043233	organelle lumen
0.32	GO:0044446	intracellular organelle part

sp|P36537|UDB10_HUMAN
UDP-glucuronosyltransferase 2B10
Search

0.54	UDP-glucuronosyltransferase

0.50	GO:0052695	cellular glucuronidation
0.41	GO:0008202	steroid metabolic process
0.38	GO:0006805	xenobiotic metabolic process
0.38	GO:0034754	cellular hormone metabolic process
0.35	GO:0018879	biphenyl metabolic process
0.35	GO:0071394	cellular response to testosterone stimulus
0.35	GO:0071361	cellular response to ethanol
0.35	GO:0007608	sensory perception of smell
0.34	GO:0071378	cellular response to growth hormone stimulus
0.34	GO:0071385	cellular response to glucocorticoid stimulus

0.79	GO:0015020	glucuronosyltransferase activity
0.39	GO:0001972	retinoic acid binding

0.44	GO:0005789	endoplasmic reticulum membrane
0.40	GO:0031090	organelle membrane
0.34	GO:0070062	extracellular exosome
0.34	GO:0005635	nuclear envelope
0.34	GO:0098805	whole membrane
0.33	GO:0019867	outer membrane
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:2.4.1.17

GO:0015020

sp|P36542|ATPG_HUMAN
ATP synthase subunit gamma, mitochondrial
Search

ATP5C1

0.71	ATP synthase subunit gamma

0.70	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.70	GO:0006754	ATP biosynthetic process
0.68	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.35	GO:0042407	cristae formation
0.35	GO:0051457	maintenance of protein location in nucleus
0.34	GO:0043433	negative regulation of DNA binding transcription factor activity
0.34	GO:0006839	mitochondrial transport
0.34	GO:0006119	oxidative phosphorylation
0.34	GO:0000122	negative regulation of transcription by RNA polymerase II
0.34	GO:0046907	intracellular transport

0.71	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
0.35	GO:0002039	p53 binding
0.34	GO:0046982	protein heterodimerization activity
0.34	GO:0003723	RNA binding

0.71	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)
0.51	GO:0005753	mitochondrial proton-transporting ATP synthase complex
0.51	GO:0043209	myelin sheath
0.36	GO:0070062	extracellular exosome
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0090575	RNA polymerase II transcription factor complex
0.34	GO:0055029	nuclear DNA-directed RNA polymerase complex
0.30	GO:0016021	integral component of membrane

sp|P36543|VATE1_HUMAN
V-type proton ATPase subunit E 1
Search

ATP6V1E1

0.97	V-type proton ATPase subunit E 1

0.76	GO:0015991	ATP hydrolysis coupled proton transport
0.45	GO:0060036	notochord cell vacuolation
0.45	GO:0033336	caudal fin development
0.44	GO:0031101	fin regeneration
0.42	GO:0060041	retina development in camera-type eye
0.35	GO:0090383	phagosome acidification
0.35	GO:0033572	transferrin transport
0.35	GO:0008286	insulin receptor signaling pathway
0.35	GO:0016241	regulation of macroautophagy

0.81	GO:0046961	proton-transporting ATPase activity, rotational mechanism
0.52	GO:0008553	proton-exporting ATPase activity, phosphorylative mechanism
0.47	GO:0051117	ATPase binding
0.44	GO:0008900	potassium:proton exchanging ATPase activity

0.72	GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
0.48	GO:0031410	cytoplasmic vesicle
0.47	GO:0005902	microvillus
0.47	GO:0016324	apical plasma membrane
0.46	GO:0012505	endomembrane system
0.44	GO:0097223	sperm part
0.43	GO:0005829	cytosol
0.40	GO:0005739	mitochondrion
0.37	GO:0005765	lysosomal membrane
0.36	GO:0070062	extracellular exosome

0.52

EC:3.6.3.6

GO:0008553

sp|P36544|ACHA7_HUMAN
Neuronal acetylcholine receptor subunit alpha-7
Search

CHRNA7

0.89	Nicotinic acetylcholine receptor subunit alpha 7

0.77	GO:0060079	excitatory postsynaptic potential
0.60	GO:0034220	ion transmembrane transport
0.51	GO:0035094	response to nicotine
0.49	GO:1905920	positive regulation of CoA-transferase activity
0.48	GO:0001988	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
0.48	GO:0050893	sensory processing
0.48	GO:0032720	negative regulation of tumor necrosis factor production
0.48	GO:0060112	generation of ovulation cycle rhythm
0.47	GO:0140059	dendrite arborization
0.47	GO:1905906	regulation of amyloid fibril formation

0.80	GO:0022848	acetylcholine-gated cation-selective channel activity
0.70	GO:0004888	transmembrane signaling receptor activity
0.42	GO:0017081	chloride channel regulator activity
0.42	GO:0042166	acetylcholine binding
0.42	GO:0001540	amyloid-beta binding
0.41	GO:0015643	toxic substance binding
0.39	GO:0042803	protein homodimerization activity
0.35	GO:0008179	adenylate cyclase binding
0.35	GO:0097110	scaffold protein binding
0.35	GO:0051117	ATPase binding

0.76	GO:0045211	postsynaptic membrane
0.72	GO:0030054	cell junction
0.55	GO:0030424	axon
0.54	GO:0043204	perikaryon
0.53	GO:0120038	plasma membrane bounded cell projection part
0.52	GO:0097447	dendritic tree
0.46	GO:0005892	acetylcholine-gated channel complex
0.44	GO:0031256	leading edge membrane
0.44	GO:0009897	external side of plasma membrane
0.44	GO:0016324	apical plasma membrane

sp|P36551|HEM6_HUMAN
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
Search

CPOX

0.46	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

0.71	GO:0006779	porphyrin-containing compound biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.50	GO:0042168	heme metabolic process
0.49	GO:0046148	pigment biosynthetic process
0.47	GO:0042541	hemoglobin biosynthetic process
0.40	GO:0010288	response to lead ion
0.40	GO:0051597	response to methylmercury
0.40	GO:0017085	response to insecticide
0.39	GO:0010039	response to iron ion
0.38	GO:0046685	response to arsenic-containing substance

0.78	GO:0004109	coproporphyrinogen oxidase activity
0.56	GO:0005212	structural constituent of eye lens
0.52	GO:0042803	protein homodimerization activity
0.35	GO:0005391	sodium:potassium-exchanging ATPase activity
0.34	GO:0003723	RNA binding

0.49	GO:0005829	cytosol
0.45	GO:0005739	mitochondrion
0.38	GO:0031970	organelle envelope lumen
0.35	GO:0019866	organelle inner membrane
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.78	EC:1.3.3.3	GO:0004109
0.78	KEGG:R03220	GO:0004109

sp|P36575|ARRC_HUMAN
Arrestin-C
Search

ARR3

0.93	Cone arrestin

0.61	GO:0007165	signal transduction
0.51	GO:0001932	regulation of protein phosphorylation
0.50	GO:0006897	endocytosis
0.46	GO:0043393	regulation of protein binding
0.45	GO:0032226	positive regulation of synaptic transmission, dopaminergic
0.45	GO:0002092	positive regulation of receptor internalization
0.45	GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
0.45	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity
0.45	GO:0032691	negative regulation of interleukin-1 beta production
0.45	GO:0032695	negative regulation of interleukin-12 production

0.58	GO:0002046	opsin binding
0.53	GO:0051219	phosphoprotein binding
0.45	GO:0043422	protein kinase B binding
0.45	GO:0031701	angiotensin receptor binding
0.42	GO:0032947	protein complex scaffold activity
0.42	GO:0031625	ubiquitin protein ligase binding
0.35	GO:0031859	platelet activating factor receptor binding
0.35	GO:0031691	alpha-1A adrenergic receptor binding
0.35	GO:0031692	alpha-1B adrenergic receptor binding
0.35	GO:0031762	follicle-stimulating hormone receptor binding

0.55	GO:0001917	photoreceptor inner segment
0.54	GO:0001750	photoreceptor outer segment
0.50	GO:0045202	synapse
0.43	GO:0030139	endocytic vesicle
0.38	GO:0005634	nucleus
0.37	GO:0005886	plasma membrane
0.36	GO:0005905	clathrin-coated pit
0.34	GO:0044309	neuron spine
0.34	GO:0030425	dendrite
0.33	GO:0005829	cytosol

sp|P36578|RL4_HUMAN
60S ribosomal protein L4
Search

RPL4

0.71	Ribosomal protein L4

0.60	GO:0006518	peptide metabolic process
0.60	GO:0043604	amide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:1901566	organonitrogen compound biosynthetic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.35	GO:0003360	brainstem development
0.35	GO:0045773	positive regulation of axon extension
0.35	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0071417	cellular response to organonitrogen compound

0.64	GO:0003735	structural constituent of ribosome
0.39	GO:0003723	RNA binding
0.35	GO:0005515	protein binding

0.61	GO:0005840	ribosome
0.48	GO:0005791	rough endoplasmic reticulum
0.43	GO:0044445	cytosolic part
0.41	GO:0005634	nucleus
0.39	GO:0044446	intracellular organelle part
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.35	GO:0031672	A band
0.35	GO:0031974	membrane-enclosed lumen
0.30	GO:0031224	intrinsic component of membrane

sp|P36639|8ODP_HUMAN
7,8-dihydro-8-oxoguanine triphosphatase
Search

NUDT1

0.65	Nudix (Nucleoside diphosphate linked moiety X)-type motif 1

0.65	GO:0006281	DNA repair
0.57	GO:0046061	dATP catabolic process
0.55	GO:0006203	dGTP catabolic process
0.54	GO:0042262	DNA protection
0.40	GO:0008584	male gonad development
0.39	GO:0046686	response to cadmium ion
0.39	GO:0007568	aging
0.37	GO:0034656	nucleobase-containing small molecule catabolic process
0.34	GO:0006979	response to oxidative stress

0.82	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
0.58	GO:0036219	GTP diphosphatase activity
0.58	GO:0035539	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
0.55	GO:0047693	ATP diphosphatase activity
0.53	GO:0030515	snoRNA binding
0.46	GO:0003924	GTPase activity
0.41	GO:0044713	2-hydroxy-adenosine triphosphate pyrophosphatase activity
0.41	GO:0044714	2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity
0.39	GO:0050072	m7G(5')pppN diphosphatase activity
0.34	GO:0046872	metal ion binding

0.50	GO:0005759	mitochondrial matrix
0.47	GO:0005829	cytosol
0.44	GO:0005634	nucleus
0.40	GO:0001669	acrosomal vesicle
0.38	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.36	GO:0031967	organelle envelope
0.36	GO:0031090	organelle membrane
0.35	GO:0005886	plasma membrane

0.82	EC:3.6.1	GO:0008413
0.58	KEGG:R00426	GO:0036219

sp|P36776|LONM_HUMAN
Lon protease homolog, mitochondrial
Search

LONP1

0.70	Lon protease homolog, mitochondrial

0.76	GO:0070407	oxidation-dependent protein catabolic process
0.74	GO:0090296	regulation of mitochondrial DNA replication
0.72	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins
0.71	GO:0051131	chaperone-mediated protein complex assembly
0.66	GO:0034599	cellular response to oxidative stress
0.51	GO:0001666	response to hypoxia
0.51	GO:0007005	mitochondrion organization
0.50	GO:0051260	protein homooligomerization
0.39	GO:0010044	response to aluminum ion
0.38	GO:0007568	aging

0.72	GO:0004176	ATP-dependent peptidase activity
0.65	GO:0004252	serine-type endopeptidase activity
0.58	GO:0043565	sequence-specific DNA binding
0.57	GO:0001018	mitochondrial promoter sequence-specific DNA binding
0.54	GO:0051880	G-quadruplex DNA binding
0.54	GO:0070182	DNA polymerase binding
0.52	GO:0032559	adenyl ribonucleotide binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0003727	single-stranded RNA binding

0.66	GO:0005759	mitochondrial matrix
0.48	GO:0009295	nucleoid
0.47	GO:0005654	nucleoplasm
0.46	GO:0005829	cytosol
0.42	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016020	membrane

0.65

GO:0004252

sp|P36871|PGM1_HUMAN
Phosphoglucomutase-1
Search

PGM1

0.83	Phosphoglucomutase-1

0.60	GO:0005975	carbohydrate metabolic process
0.43	GO:0006112	energy reserve metabolic process
0.41	GO:0044282	small molecule catabolic process
0.40	GO:1901575	organic substance catabolic process
0.37	GO:0009059	macromolecule biosynthetic process
0.36	GO:0044260	cellular macromolecule metabolic process
0.36	GO:0044249	cellular biosynthetic process
0.36	GO:0071259	cellular response to magnetism
0.35	GO:0043312	neutrophil degranulation
0.34	GO:0006874	cellular calcium ion homeostasis

0.74	GO:0016868	intramolecular transferase activity, phosphotransferases
0.64	GO:0000287	magnesium ion binding
0.39	GO:0005509	calcium ion binding
0.33	GO:0005515	protein binding

0.47	GO:0015629	actin cytoskeleton
0.42	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome
0.35	GO:1904724	tertiary granule lumen
0.35	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0016529	sarcoplasmic reticulum
0.35	GO:0030018	Z disc
0.30	GO:0031224	intrinsic component of membrane

0.74

EC:5.4.2

GO:0016868

sp|P36873|PP1G_HUMAN
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Search

PPP1CC

0.49	Serine/threonine-protein phosphatase

0.72	GO:0006470	protein dephosphorylation
0.59	GO:0043153	entrainment of circadian clock by photoperiod
0.58	GO:0032922	circadian regulation of gene expression
0.50	GO:0046822	regulation of nucleocytoplasmic transport
0.48	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
0.46	GO:0048754	branching morphogenesis of an epithelial tube
0.46	GO:0030324	lung development
0.44	GO:0098609	cell-cell adhesion
0.42	GO:0005977	glycogen metabolic process
0.40	GO:0051301	cell division

0.77	GO:0004722	protein serine/threonine phosphatase activity
0.54	GO:0046872	metal ion binding
0.51	GO:0047485	protein N-terminus binding
0.48	GO:0019901	protein kinase binding
0.48	GO:0098641	cadherin binding involved in cell-cell adhesion
0.41	GO:0008157	protein phosphatase 1 binding
0.39	GO:0005521	lamin binding
0.38	GO:0032403	protein complex binding
0.38	GO:0008022	protein C-terminus binding
0.37	GO:0019904	protein domain specific binding

0.84	GO:0000164	protein phosphatase type 1 complex
0.65	GO:0072357	PTW/PP1 phosphatase complex
0.55	GO:0000784	nuclear chromosome, telomeric region
0.49	GO:0005730	nucleolus
0.48	GO:0005741	mitochondrial outer membrane
0.46	GO:0005913	cell-cell adherens junction
0.46	GO:0005654	nucleoplasm
0.42	GO:0005829	cytosol
0.42	GO:0032154	cleavage furrow
0.42	GO:0043234	protein complex

sp|P36888|FLT3_HUMAN
Receptor-type tyrosine-protein kinase FLT3
Search

FLT3

0.97	Fms related tyrosine kinase 3

0.80	GO:0030097	hemopoiesis
0.77	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.72	GO:0030154	cell differentiation
0.41	GO:0036145	dendritic cell homeostasis
0.41	GO:2001184	positive regulation of interleukin-12 secretion
0.41	GO:0045578	negative regulation of B cell differentiation
0.41	GO:0035726	common myeloid progenitor cell proliferation
0.40	GO:1902715	positive regulation of interferon-gamma secretion
0.40	GO:1902741	positive regulation of interferon-alpha secretion

0.80	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.73	GO:0043621	protein self-association
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0035259	glucocorticoid receptor binding
0.40	GO:0043548	phosphatidylinositol 3-kinase binding
0.39	GO:0004896	cytokine receptor activity
0.38	GO:0031625	ubiquitin protein ligase binding
0.38	GO:0032403	protein complex binding

0.61	GO:0005783	endoplasmic reticulum
0.39	GO:0009897	external side of plasma membrane
0.37	GO:0005829	cytosol
0.35	GO:0005634	nucleus
0.35	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

0.80

EC:2.7.10.1

GO:0004714

sp|P36894|BMR1A_HUMAN
Bone morphogenetic protein receptor type-1A
Search

BMPR1A

0.61	Receptor protein serine/threonine kinase

0.80	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.66	GO:0023014	signal transduction by protein phosphorylation
0.58	GO:0002062	chondrocyte differentiation
0.58	GO:0021998	neural plate mediolateral regionalization
0.58	GO:1905285	fibrous ring of heart morphogenesis
0.58	GO:0048352	paraxial mesoderm structural organization
0.57	GO:1904414	positive regulation of cardiac ventricle development
0.57	GO:0071773	cellular response to BMP stimulus
0.57	GO:0001880	Mullerian duct regression
0.57	GO:0048378	regulation of lateral mesodermal cell fate specification

0.83	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
0.79	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0046332	SMAD binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.49	GO:0042803	protein homodimerization activity
0.48	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.38	GO:0046872	metal ion binding

0.53	GO:0005901	caveola
0.52	GO:0009897	external side of plasma membrane
0.46	GO:0043235	receptor complex
0.40	GO:0005887	integral component of plasma membrane
0.37	GO:0089717	spanning component of membrane
0.34	GO:0043025	neuronal cell body
0.34	GO:0030425	dendrite

0.83

GO:0004675

sp|P36896|ACV1B_HUMAN
Activin receptor type-1B
Search

ACVR1B

0.65	Receptor protein serine/threonine kinase

0.80	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.66	GO:0023014	signal transduction by protein phosphorylation
0.57	GO:1901165	positive regulation of trophoblast cell migration
0.57	GO:0032927	positive regulation of activin receptor signaling pathway
0.56	GO:0045648	positive regulation of erythrocyte differentiation
0.54	GO:0097191	extrinsic apoptotic signaling pathway
0.54	GO:0018107	peptidyl-threonine phosphorylation
0.54	GO:0030308	negative regulation of cell growth
0.53	GO:0000082	G1/S transition of mitotic cell cycle
0.53	GO:0001942	hair follicle development

0.83	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
0.80	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
0.58	GO:0034711	inhibin binding
0.57	GO:0048185	activin binding
0.55	GO:0030554	adenyl nucleotide binding
0.55	GO:0046332	SMAD binding
0.54	GO:0019838	growth factor binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.57	GO:0048179	activin receptor complex
0.50	GO:0009986	cell surface
0.47	GO:0005829	cytosol
0.37	GO:0031982	vesicle
0.36	GO:0043230	extracellular organelle
0.35	GO:0005615	extracellular space
0.35	GO:0005923	bicellular tight junction
0.35	GO:0098857	membrane microdomain
0.34	GO:0012505	endomembrane system
0.33	GO:0043231	intracellular membrane-bounded organelle

0.83

GO:0004675

sp|P36897|TGFR1_HUMAN
TGF-beta receptor type-1
Search

TGFBR1

0.61	Receptor protein serine/threonine kinase

0.80	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.68	GO:0042118	endothelial cell activation
0.67	GO:0060317	cardiac epithelial to mesenchymal transition
0.66	GO:0023014	signal transduction by protein phosphorylation
0.65	GO:0010717	regulation of epithelial to mesenchymal transition
0.65	GO:0001938	positive regulation of endothelial cell proliferation
0.63	GO:0071560	cellular response to transforming growth factor beta stimulus
0.57	GO:0045893	positive regulation of transcription, DNA-templated
0.55	GO:1905223	epicardium morphogenesis
0.54	GO:0060391	positive regulation of SMAD protein import into nucleus

0.83	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
0.80	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
0.67	GO:0050431	transforming growth factor beta binding
0.55	GO:0030554	adenyl nucleotide binding
0.55	GO:0005114	type II transforming growth factor beta receptor binding
0.55	GO:0070411	I-SMAD binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0046872	metal ion binding

0.51	GO:0005923	bicellular tight junction
0.51	GO:0098857	membrane microdomain
0.50	GO:0043235	receptor complex
0.49	GO:0009986	cell surface
0.47	GO:0005768	endosome
0.41	GO:0005886	plasma membrane
0.41	GO:0043231	intracellular membrane-bounded organelle
0.36	GO:1902554	serine/threonine protein kinase complex
0.34	GO:0045177	apical part of cell
0.33	GO:0043234	protein complex

0.83

GO:0004675

sp|P36915|GNL1_HUMAN
Guanine nucleotide-binding protein-like 1
Search

GNL1

0.91	G protein nucleolar 1 (putative)

0.57	GO:0006974	cellular response to DNA damage stimulus
0.49	GO:0042254	ribosome biogenesis

0.66	GO:0001883	purine nucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.65	GO:0032549	ribonucleoside binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0003924	GTPase activity

sp|P36941|TNR3_HUMAN
Tumor necrosis factor receptor superfamily member 3
Search

LTBR

0.97	Lymphotoxin beta receptor

0.83	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.79	GO:0048534	hematopoietic or lymphoid organ development
0.73	GO:0006955	immune response
0.64	GO:0001773	myeloid dendritic cell activation
0.64	GO:0071260	cellular response to mechanical stimulus
0.64	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
0.62	GO:0046330	positive regulation of JNK cascade
0.54	GO:0030154	cell differentiation
0.54	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.53	GO:0032496	response to lipopolysaccharide

0.59	GO:0031625	ubiquitin protein ligase binding
0.56	GO:0042802	identical protein binding
0.56	GO:0005031	tumor necrosis factor-activated receptor activity
0.34	GO:0048406	nerve growth factor binding

0.55	GO:0005794	Golgi apparatus
0.46	GO:0005887	integral component of plasma membrane
0.33	GO:0043005	neuron projection
0.32	GO:0005634	nucleus
0.32	GO:0005581	collagen trimer

sp|P36952|SPB5_HUMAN
Serpin B5
Search

SERPINB5

0.97	Serpin peptidase inhibitor, clade B, member 5 (Fragment)

0.73	GO:0010951	negative regulation of endopeptidase activity
0.63	GO:0060512	prostate gland morphogenesis
0.59	GO:0050678	regulation of epithelial cell proliferation
0.59	GO:0030198	extracellular matrix organization
0.58	GO:0002009	morphogenesis of an epithelium
0.33	GO:0002244	hematopoietic progenitor cell differentiation

0.75	GO:0004867	serine-type endopeptidase inhibitor activity
0.34	GO:0005515	protein binding

0.71	GO:0005615	extracellular space
0.41	GO:0005737	cytoplasm
0.38	GO:1903561	extracellular vesicle
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P36954|RPB9_HUMAN
DNA-directed RNA polymerase II subunit RPB9
Search

POLR2I

0.50	DNA-directed RNA polymerase subunit

0.80	GO:0006379	mRNA cleavage
0.58	GO:0006351	transcription, DNA-templated
0.46	GO:0006283	transcription-coupled nucleotide-excision repair
0.35	GO:0035019	somatic stem cell population maintenance
0.35	GO:0060964	regulation of gene silencing by miRNA
0.35	GO:0008543	fibroblast growth factor receptor signaling pathway
0.34	GO:0016073	snRNA metabolic process
0.34	GO:0050434	positive regulation of viral transcription
0.34	GO:0000398	mRNA splicing, via spliceosome
0.34	GO:0006370	7-methylguanosine mRNA capping

0.68	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.62	GO:0008270	zinc ion binding
0.50	GO:0003676	nucleic acid binding

0.68	GO:0005730	nucleolus
0.55	GO:0005665	DNA-directed RNA polymerase II, core complex

0.68

GO:0003899

sp|P36955|PEDF_HUMAN
Pigment epithelium-derived factor
Search

SERPINF1

0.94	Pigment epithelium-derived factor

0.78	GO:0016525	negative regulation of angiogenesis
0.76	GO:0050769	positive regulation of neurogenesis
0.65	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
0.47	GO:0010951	negative regulation of endopeptidase activity
0.43	GO:0071279	cellular response to cobalt ion
0.42	GO:0071549	cellular response to dexamethasone stimulus
0.42	GO:0007614	short-term memory
0.42	GO:0071300	cellular response to retinoic acid
0.41	GO:0010596	negative regulation of endothelial cell migration
0.41	GO:0071333	cellular response to glucose stimulus

0.48	GO:0004867	serine-type endopeptidase inhibitor activity
0.34	GO:0005515	protein binding
0.33	GO:0008233	peptidase activity

0.73	GO:0005615	extracellular space
0.55	GO:0031012	extracellular matrix
0.42	GO:0043203	axon hillock
0.40	GO:0048471	perinuclear region of cytoplasm
0.40	GO:0042470	melanosome
0.37	GO:1903561	extracellular vesicle
0.30	GO:0016020	membrane

0.33

GO:0008233

sp|P36956|SRBP1_HUMAN
Sterol regulatory element-binding protein 1
Search

SREBF1

0.93	Sterol regulatory element binding transcription factor 1

0.56	GO:0003062	regulation of heart rate by chemical signal
0.56	GO:0045542	positive regulation of cholesterol biosynthetic process
0.56	GO:0010867	positive regulation of triglyceride biosynthetic process
0.54	GO:0031065	positive regulation of histone deacetylation
0.54	GO:0042789	mRNA transcription by RNA polymerase II
0.54	GO:0046676	negative regulation of insulin secretion
0.53	GO:0008286	insulin receptor signaling pathway
0.52	GO:0045444	fat cell differentiation
0.52	GO:0009749	response to glucose
0.52	GO:1903146	regulation of autophagy of mitochondrion

0.68	GO:0046983	protein dimerization activity
0.56	GO:0032810	sterol response element binding
0.51	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.51	GO:0004879	nuclear receptor activity
0.50	GO:0019901	protein kinase binding
0.49	GO:0003682	chromatin binding
0.38	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.38	GO:0032403	protein complex binding

0.44	GO:0005634	nucleus
0.40	GO:0012507	ER to Golgi transport vesicle membrane
0.39	GO:0000139	Golgi membrane
0.39	GO:0005789	endoplasmic reticulum membrane
0.35	GO:0070013	intracellular organelle lumen
0.35	GO:0043234	protein complex
0.34	GO:0005829	cytosol
0.34	GO:0031967	organelle envelope
0.30	GO:0016021	integral component of membrane

sp|P36957|ODO2_HUMAN
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Search

DLST

0.68	Alpha-ketoglutarate dehydrogenase complex dihydrolipoyl succinyltransferase

0.70	GO:0006099	tricarboxylic acid cycle
0.60	GO:0018335	protein succinylation
0.42	GO:0070584	mitochondrion morphogenesis
0.42	GO:0006104	succinyl-CoA metabolic process
0.41	GO:0060047	heart contraction
0.40	GO:0006103	2-oxoglutarate metabolic process
0.40	GO:0030097	hemopoiesis
0.40	GO:0033512	L-lysine catabolic process to acetyl-CoA via saccharopine
0.38	GO:0006754	ATP biosynthetic process
0.35	GO:0006734	NADH metabolic process

0.80	GO:0016751	S-succinyltransferase activity
0.57	GO:0140096	catalytic activity, acting on a protein
0.34	GO:0031072	heat shock protein binding
0.34	GO:0051087	chaperone binding

0.79	GO:0045252	oxoglutarate dehydrogenase complex
0.54	GO:0043209	myelin sheath
0.45	GO:0005739	mitochondrion
0.45	GO:0005634	nucleus
0.36	GO:0070062	extracellular exosome
0.35	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.80

GO:0016751

sp|P36959|GMPR1_HUMAN
GMP reductase 1
Search

GMPR

0.58	GMP reductase

0.71	GO:0006144	purine nucleobase metabolic process
0.59	GO:0009117	nucleotide metabolic process
0.52	GO:0055114	oxidation-reduction process
0.37	GO:0072522	purine-containing compound biosynthetic process
0.36	GO:0009409	response to cold
0.35	GO:1901293	nucleoside phosphate biosynthetic process
0.35	GO:0043094	cellular metabolic compound salvage
0.35	GO:1901068	guanosine-containing compound metabolic process
0.34	GO:0009126	purine nucleoside monophosphate metabolic process
0.33	GO:0009161	ribonucleoside monophosphate metabolic process

0.82	GO:0003920	GMP reductase activity
0.53	GO:0046872	metal ion binding
0.37	GO:0003938	IMP dehydrogenase activity

0.81	GO:1902560	GMP reductase complex
0.34	GO:0005829	cytosol

0.82	EC:1.7.1.7	GO:0003920
0.82	KEGG:R01134	GO:0003920

sp|P36969|GPX4_HUMAN
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
Search

GPX4

0.45	Mitochondrial phospholipid hydroperoxide glutathione peroxidase

0.71	GO:0006979	response to oxidative stress
0.69	GO:0098869	cellular oxidant detoxification
0.53	GO:0055114	oxidation-reduction process
0.50	GO:0110075	regulation of ferroptosis
0.46	GO:0007283	spermatogenesis
0.44	GO:0043069	negative regulation of programmed cell death
0.43	GO:0051258	protein polymerization
0.43	GO:0007275	multicellular organism development
0.38	GO:0006325	chromatin organization
0.37	GO:0032355	response to estradiol

0.79	GO:0004602	glutathione peroxidase activity
0.50	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity
0.42	GO:0042802	identical protein binding
0.37	GO:0008430	selenium binding
0.32	GO:0005249	voltage-gated potassium channel activity
0.32	GO:0016787	hydrolase activity

0.43	GO:0005739	mitochondrion
0.43	GO:0005654	nucleoplasm
0.38	GO:0005635	nuclear envelope
0.38	GO:0070062	extracellular exosome
0.38	GO:0043234	protein complex
0.38	GO:0005829	cytosol
0.36	GO:0019866	organelle inner membrane
0.33	GO:0099023	tethering complex
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:1.11.1.9

GO:0004602

sp|P36980|FHR2_HUMAN
Complement factor H-related protein 2
Search

0.81	Complement factor H

0.75	GO:0045919	positive regulation of cytolysis
0.69	GO:0032091	negative regulation of protein binding
0.56	GO:0030449	regulation of complement activation
0.55	GO:0006956	complement activation
0.45	GO:0045087	innate immune response
0.35	GO:0006869	lipid transport
0.34	GO:0016032	viral process

0.62	GO:0042803	protein homodimerization activity
0.61	GO:0046982	protein heterodimerization activity
0.49	GO:0043395	heparan sulfate proteoglycan binding
0.48	GO:0008201	heparin binding
0.41	GO:0001851	complement component C3b binding
0.35	GO:0005319	lipid transporter activity

0.57	GO:0072562	blood microparticle
0.55	GO:0070062	extracellular exosome
0.51	GO:0043234	protein complex
0.30	GO:0016020	membrane

sp|P37023|ACVL1_HUMAN
Serine/threonine-protein kinase receptor R3
Search

ACVRL1

0.61	Serine/threonine-protein kinase receptor

0.80	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.66	GO:0023014	signal transduction by protein phosphorylation
0.59	GO:0060836	lymphatic endothelial cell differentiation
0.59	GO:0003203	endocardial cushion morphogenesis
0.58	GO:0045602	negative regulation of endothelial cell differentiation
0.58	GO:0035912	dorsal aorta morphogenesis
0.58	GO:0035313	wound healing, spreading of epidermal cells
0.58	GO:0045603	positive regulation of endothelial cell differentiation
0.58	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.58	GO:0071773	cellular response to BMP stimulus

0.82	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
0.80	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
0.60	GO:0048185	activin binding
0.59	GO:0050431	transforming growth factor beta binding
0.57	GO:0046332	SMAD binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0019901	protein kinase binding

0.51	GO:0009986	cell surface
0.48	GO:0005887	integral component of plasma membrane
0.41	GO:0043235	receptor complex
0.39	GO:0043025	neuronal cell body
0.39	GO:0030425	dendrite
0.39	GO:0045177	apical part of cell
0.39	GO:1902554	serine/threonine protein kinase complex
0.34	GO:0005938	cell cortex

0.82

GO:0004675

sp|P37058|DHB3_HUMAN
Testosterone 17-beta-dehydrogenase 3
Search

HSD17B3

0.74	Very-long-chain 3-oxoacyl-CoA reductase

0.75	GO:0061370	testosterone biosynthetic process
0.73	GO:0030539	male genitalia development
0.50	GO:0055114	oxidation-reduction process
0.43	GO:0006702	androgen biosynthetic process
0.39	GO:0007030	Golgi organization
0.39	GO:0033555	multicellular organismal response to stress
0.39	GO:0008285	negative regulation of cell proliferation
0.37	GO:0006703	estrogen biosynthetic process
0.36	GO:0018879	biphenyl metabolic process
0.36	GO:0017143	insecticide metabolic process

0.76	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity
0.40	GO:0047044	androstan-3-alpha,17-beta-diol dehydrogenase activity
0.40	GO:0004303	estradiol 17-beta-dehydrogenase activity
0.39	GO:0047035	testosterone dehydrogenase (NAD+) activity
0.38	GO:0102341	3-oxo-lignoceroyl-CoA reductase activity
0.38	GO:0102340	3-oxo-behenoyl-CoA reductase activity
0.38	GO:0102342	3-oxo-cerotoyl-CoA reductase activity
0.38	GO:0102339	3-oxo-arachidoyl-CoA reductase activity
0.36	GO:0001968	fibronectin binding
0.36	GO:0005518	collagen binding

0.52	GO:0005783	endoplasmic reticulum
0.37	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0031984	organelle subcompartment
0.35	GO:0005578	proteinaceous extracellular matrix
0.32	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.76	EC:1.1.1.64	GO:0047045
0.76	KEGG:R01838	GO:0047045

sp|P37059|DHB2_HUMAN
Estradiol 17-beta-dehydrogenase 2
Search

HSD17B2

0.97	Corticosteroid 11-beta-dehydrogenase isozyme 2

0.59	GO:0032526	response to retinoic acid
0.56	GO:0001890	placenta development
0.54	GO:0001701	in utero embryonic development
0.51	GO:0055114	oxidation-reduction process
0.39	GO:0006703	estrogen biosynthetic process
0.37	GO:0006702	androgen biosynthetic process
0.35	GO:0060348	bone development
0.35	GO:0071248	cellular response to metal ion
0.35	GO:0034650	cortisol metabolic process
0.32	GO:0019290	siderophore biosynthetic process

0.62	GO:0047035	testosterone dehydrogenase (NAD+) activity
0.60	GO:0004303	estradiol 17-beta-dehydrogenase activity
0.38	GO:0008709	cholate 7-alpha-dehydrogenase activity
0.38	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
0.35	GO:0070523	11-beta-hydroxysteroid dehydrogenase (NAD+) activity
0.35	GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity
0.34	GO:0004745	retinol dehydrogenase activity
0.33	GO:0016407	acetyltransferase activity
0.32	GO:0008667	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
0.32	GO:0003858	3-hydroxybutyrate dehydrogenase activity

0.35	GO:0005789	endoplasmic reticulum membrane
0.32	GO:0005681	spliceosomal complex
0.30	GO:0016021	integral component of membrane

0.62	EC:1.1.1.239	GO:0047035
0.62	KEGG:R01836	GO:0047035

sp|P37088|SCNNA_HUMAN
Amiloride-sensitive sodium channel subunit alpha
Search

SCNN1A

0.97	Amiloride-sensitive sodium channel subunit alpha

0.77	GO:0035725	sodium ion transmembrane transport
0.61	GO:0055078	sodium ion homeostasis
0.60	GO:0050891	multicellular organismal water homeostasis
0.44	GO:0050909	sensory perception of taste
0.37	GO:0050896	response to stimulus
0.35	GO:0008217	regulation of blood pressure
0.34	GO:0016192	vesicle-mediated transport
0.34	GO:0016567	protein ubiquitination

0.85	GO:0015280	ligand-gated sodium channel activity
0.59	GO:0050699	WW domain binding
0.35	GO:0003779	actin binding
0.34	GO:0061630	ubiquitin protein ligase activity
0.33	GO:0008270	zinc ion binding

0.60	GO:0060170	ciliary membrane
0.58	GO:0034706	sodium channel complex
0.58	GO:0016324	apical plasma membrane
0.56	GO:0031514	motile cilium
0.55	GO:0070062	extracellular exosome
0.49	GO:0005887	integral component of plasma membrane
0.40	GO:0005737	cytoplasm
0.37	GO:0009897	external side of plasma membrane
0.36	GO:0015629	actin cytoskeleton
0.34	GO:0044430	cytoskeletal part

sp|P37108|SRP14_HUMAN
Signal recognition particle 14 kDa protein
Search

SRP14

0.44	Signal recognition particle 14

0.72	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.46	GO:0042493	response to drug
0.36	GO:0043312	neutrophil degranulation

0.81	GO:0030942	endoplasmic reticulum signal peptide binding
0.75	GO:0008312	7S RNA binding
0.36	GO:0050825	ice binding
0.33	GO:0005515	protein binding

0.78	GO:0005786	signal recognition particle, endoplasmic reticulum targeting
0.43	GO:0005634	nucleus
0.36	GO:1904813	ficolin-1-rich granule lumen
0.36	GO:0034774	secretory granule lumen
0.35	GO:0070062	extracellular exosome
0.35	GO:0005829	cytosol

sp|P37173|TGFR2_HUMAN
TGF-beta receptor type-2
Search

TGFBR2

0.74	Serine/threonine-protein kinase receptor

0.80	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.73	GO:0071560	cellular response to transforming growth factor beta stimulus
0.66	GO:0023014	signal transduction by protein phosphorylation
0.63	GO:0006915	apoptotic process
0.61	GO:0040008	regulation of growth
0.59	GO:0030154	cell differentiation
0.57	GO:1905317	inferior endocardial cushion morphogenesis
0.57	GO:0002651	positive regulation of tolerance induction to self antigen
0.57	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation
0.57	GO:0060434	bronchus morphogenesis

0.86	GO:0005026	transforming growth factor beta receptor activity, type II
0.79	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
0.56	GO:0034713	type I transforming growth factor beta receptor binding
0.56	GO:0050431	transforming growth factor beta binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0046872	metal ion binding
0.53	GO:0046332	SMAD binding

0.69	GO:0043235	receptor complex
0.52	GO:0005901	caveola
0.51	GO:0009897	external side of plasma membrane
0.37	GO:1902554	serine/threonine protein kinase complex
0.35	GO:0005829	cytosol
0.35	GO:0005887	integral component of plasma membrane
0.34	GO:0031012	extracellular matrix

0.79

GO:0004702

sp|P37198|NUP62_HUMAN
Nuclear pore glycoprotein p62
Search

NUP62

0.91	Nucleoporin 62 like

0.70	GO:0051169	nuclear transport
0.59	GO:0046601	positive regulation of centriole replication
0.58	GO:1904781	positive regulation of protein localization to centrosome
0.57	GO:0007100	mitotic centrosome separation
0.56	GO:1903438	positive regulation of mitotic cytokinetic process
0.55	GO:0007080	mitotic metaphase plate congression
0.55	GO:0098534	centriole assembly
0.55	GO:0045840	positive regulation of mitotic nuclear division
0.55	GO:0060236	regulation of mitotic spindle organization
0.54	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling

0.80	GO:0017056	structural constituent of nuclear pore
0.57	GO:0046966	thyroid hormone receptor binding
0.56	GO:0042169	SH2 domain binding
0.56	GO:0030159	receptor signaling complex scaffold activity
0.54	GO:0051425	PTB domain binding
0.53	GO:0043130	ubiquitin binding
0.52	GO:0051879	Hsp90 protein binding
0.52	GO:0030544	Hsp70 protein binding
0.43	GO:0005543	phospholipid binding
0.42	GO:0019894	kinesin binding

0.78	GO:0005643	nuclear pore
0.57	GO:0090543	Flemming body
0.53	GO:0072686	mitotic spindle
0.52	GO:0031965	nuclear membrane
0.52	GO:0000922	spindle pole
0.52	GO:0005813	centrosome
0.44	GO:0030529	intracellular ribonucleoprotein complex
0.43	GO:0005642	annulate lamellae
0.39	GO:0005737	cytoplasm

sp|P37231|PPARG_HUMAN
Peroxisome proliferator-activated receptor gamma
Search

PPARG

0.93	Peroxisome proliferator-activated receptor gamma

0.80	GO:0048511	rhythmic process
0.79	GO:0030522	intracellular receptor signaling pathway
0.77	GO:0043401	steroid hormone mediated signaling pathway
0.60	GO:0010742	macrophage derived foam cell differentiation
0.60	GO:0045713	low-density lipoprotein particle receptor biosynthetic process
0.59	GO:1905563	negative regulation of vascular endothelial cell proliferation
0.59	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process
0.59	GO:0010887	negative regulation of cholesterol storage
0.59	GO:0060331	negative regulation of response to interferon-gamma
0.59	GO:0010871	negative regulation of receptor biosynthetic process

0.82	GO:0004879	nuclear receptor activity
0.78	GO:0003707	steroid hormone receptor activity
0.64	GO:0043565	sequence-specific DNA binding
0.62	GO:0008270	zinc ion binding
0.59	GO:0050692	DBD domain binding
0.59	GO:0050693	LBD domain binding
0.58	GO:0046965	retinoid X receptor binding
0.57	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
0.57	GO:0051393	alpha-actinin binding
0.56	GO:0043621	protein self-association

0.61	GO:0005634	nucleus
0.51	GO:0005667	transcription factor complex
0.48	GO:0005737	cytoplasm
0.43	GO:0044446	intracellular organelle part
0.35	GO:0070013	intracellular organelle lumen
0.30	GO:0016021	integral component of membrane

sp|P37235|HPCL1_HUMAN
Hippocalcin-like protein 1
Search

HPCAL1

0.87	Hippocalcin-like protein 1

0.70	GO:0005509	calcium ion binding
0.36	GO:0005515	protein binding

0.38	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

sp|P37268|FDFT_HUMAN
Squalene synthase
Search

FDFT1

0.85	Farnesyl-diphosphate farnesyltransferase 1

0.80	GO:0006696	ergosterol biosynthetic process
0.51	GO:0045338	farnesyl diphosphate metabolic process
0.50	GO:0006695	cholesterol biosynthetic process

0.80	GO:0004310	farnesyl-diphosphate farnesyltransferase activity
0.80	GO:0051996	squalene synthase activity

0.55	GO:0005783	endoplasmic reticulum
0.45	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.44	GO:0031984	organelle subcompartment
0.30	GO:0031224	intrinsic component of membrane

0.80

EC:2.5.1.21

GO:0004310

sp|P37275|ZEB1_HUMAN
Zinc finger E-box-binding homeobox 1
Search

ZEB1

0.97	Zinc finger E-box-binding homeobox 1

0.61	GO:0045602	negative regulation of endothelial cell differentiation
0.59	GO:0048752	semicircular canal morphogenesis
0.58	GO:0090103	cochlea morphogenesis
0.58	GO:0033081	regulation of T cell differentiation in thymus
0.58	GO:0051150	regulation of smooth muscle cell differentiation
0.58	GO:0048596	embryonic camera-type eye morphogenesis
0.58	GO:0010464	regulation of mesenchymal cell proliferation
0.56	GO:0071230	cellular response to amino acid stimulus
0.56	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
0.56	GO:0048704	embryonic skeletal system morphogenesis

0.58	GO:0070888	E-box binding
0.56	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.52	GO:0003682	chromatin binding
0.50	GO:0008134	transcription factor binding
0.41	GO:0046872	metal ion binding
0.35	GO:0003714	transcription corepressor activity
0.35	GO:0003713	transcription coactivator activity

0.59	GO:0005634	nucleus
0.51	GO:0005667	transcription factor complex
0.49	GO:0005829	cytosol
0.48	GO:0031974	membrane-enclosed lumen
0.44	GO:0044446	intracellular organelle part

sp|P37287|PIGA_HUMAN
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
Search

PIGA

0.89	Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

0.77	GO:0006506	GPI anchor biosynthetic process
0.55	GO:1990830	cellular response to leukemia inhibitory factor
0.34	GO:0009893	positive regulation of metabolic process
0.33	GO:0016567	protein ubiquitination
0.32	GO:0035556	intracellular signal transduction

0.54	GO:0016757	transferase activity, transferring glycosyl groups
0.33	GO:0005515	protein binding

0.61	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
0.30	GO:0031224	intrinsic component of membrane

0.54

EC:2.4

GO:0016757

sp|P37288|V1AR_HUMAN
Vasopressin V1a receptor
Search

AVPR1A

0.97	Vasopressin V1a receptor

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.60	GO:0001992	regulation of systemic arterial blood pressure by vasopressin
0.48	GO:0045907	positive regulation of vasoconstriction
0.48	GO:0042711	maternal behavior
0.45	GO:1901652	response to peptide
0.44	GO:0009725	response to hormone
0.43	GO:0071495	cellular response to endogenous stimulus
0.43	GO:0071310	cellular response to organic substance
0.43	GO:0043084	penile erection
0.43	GO:0002125	maternal aggressive behavior

0.85	GO:0005000	vasopressin receptor activity
0.46	GO:0042277	peptide binding
0.43	GO:0031894	V1A vasopressin receptor binding
0.41	GO:0042562	hormone binding
0.35	GO:0005080	protein kinase C binding

0.49	GO:0005886	plasma membrane
0.38	GO:0031410	cytoplasmic vesicle
0.34	GO:0012506	vesicle membrane
0.34	GO:0012505	endomembrane system
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

sp|P37802|TAGL2_HUMAN
Transgelin-2
Search

TAGLN2

0.80	Transgelin

0.53	GO:0030855	epithelial cell differentiation
0.52	GO:0000122	negative regulation of transcription by RNA polymerase II
0.41	GO:0000902	cell morphogenesis
0.41	GO:0030036	actin cytoskeleton organization
0.37	GO:0002576	platelet degranulation
0.35	GO:0007417	central nervous system development
0.33	GO:0006508	proteolysis

0.69	GO:0051015	actin filament binding
0.54	GO:0045296	cadherin binding
0.34	GO:0004252	serine-type endopeptidase activity

0.54	GO:0043209	myelin sheath
0.44	GO:0005634	nucleus
0.41	GO:0015629	actin cytoskeleton
0.38	GO:0070062	extracellular exosome
0.35	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.34

GO:0004252

sp|P37837|TALDO_HUMAN
Transaldolase
Search

TALDO1

0.55	Transaldolase

0.72	GO:0006098	pentose-phosphate shunt
0.60	GO:0005975	carbohydrate metabolic process
0.38	GO:0006002	fructose 6-phosphate metabolic process
0.36	GO:0035722	interleukin-12-mediated signaling pathway
0.33	GO:0044283	small molecule biosynthetic process
0.32	GO:1901576	organic substance biosynthetic process

0.79	GO:0004801	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity
0.38	GO:0048029	monosaccharide binding
0.33	GO:0005515	protein binding

0.49	GO:0005737	cytoplasm
0.48	GO:0005654	nucleoplasm
0.36	GO:0070062	extracellular exosome
0.34	GO:0030445	yeast-form cell wall
0.34	GO:0030446	hyphal cell wall
0.34	GO:0097311	biofilm matrix
0.33	GO:0009986	cell surface
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:2.2.1.2

GO:0004801

sp|P37840|SYUA_HUMAN
Alpha-synuclein
Search

SNCA

0.97	Alpha-synuclein

0.83	GO:0014059	regulation of dopamine secretion
0.61	GO:0042417	dopamine metabolic process
0.59	GO:0051945	negative regulation of catecholamine uptake involved in synaptic transmission
0.59	GO:0051621	regulation of norepinephrine uptake
0.59	GO:1903284	positive regulation of glutathione peroxidase activity
0.59	GO:1903285	positive regulation of hydrogen peroxide catabolic process
0.59	GO:1904715	negative regulation of chaperone-mediated autophagy
0.59	GO:0032227	negative regulation of synaptic transmission, dopaminergic
0.59	GO:0051612	negative regulation of serotonin uptake
0.58	GO:0043524	negative regulation of neuron apoptotic process

0.62	GO:1903136	cuprous ion binding
0.58	GO:0048156	tau protein binding
0.57	GO:0050544	arachidonic acid binding
0.56	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.56	GO:0043014	alpha-tubulin binding
0.56	GO:0030544	Hsp70 protein binding
0.55	GO:0019894	kinesin binding
0.54	GO:0070840	dynein complex binding
0.54	GO:0051219	phosphoprotein binding
0.52	GO:0042393	histone binding

0.59	GO:0016234	inclusion body
0.58	GO:0031092	platelet alpha granule membrane
0.56	GO:0045202	synapse
0.54	GO:0030426	growth cone
0.53	GO:0043025	neuronal cell body
0.52	GO:0030424	axon
0.52	GO:0048471	perinuclear region of cytoplasm
0.51	GO:0005615	extracellular space
0.50	GO:0005938	cell cortex
0.50	GO:0005829	cytosol

0.41

GO:0016491

sp|P38117|ETFB_HUMAN
Electron transfer flavoprotein subunit beta
Search

ETFB

0.84	Electron-transfer-flavoprotein beta polypeptide

0.61

GO:0022900

electron transport chain

0.62

GO:0009055

electron transfer activity

0.42

GO:0005829

cytosol

sp|P38159|RBMX_HUMAN
RNA-binding motif protein, X chromosome
Search

RBMX

0.86	Heterogeneous nuclear ribonucleoprotein G

0.34

GO:0045944

positive regulation of transcription by RNA polymerase II

0.59	GO:0003723	RNA binding
0.35	GO:0001047	core promoter binding
0.34	GO:0003682	chromatin binding

0.71	GO:0019013	viral nucleocapsid
0.61	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0005634	nucleus
0.30	GO:0044425	membrane part

sp|P38398|BRCA1_HUMAN
Breast cancer type 1 susceptibility protein
Search

BRCA1

0.91	Breast cancer type 1 susceptibility protein homolog

0.80	GO:0085020	protein K6-linked ubiquitination
0.75	GO:0051865	protein autoubiquitination
0.63	GO:0006281	DNA repair
0.60	GO:0007049	cell cycle
0.59	GO:0006310	DNA recombination
0.55	GO:0009048	dosage compensation by inactivation of X chromosome
0.54	GO:0045717	negative regulation of fatty acid biosynthetic process
0.53	GO:0035067	negative regulation of histone acetylation
0.53	GO:0071158	positive regulation of cell cycle arrest
0.53	GO:0035066	positive regulation of histone acetylation

0.72	GO:0004842	ubiquitin-protein transferase activity
0.62	GO:0008270	zinc ion binding
0.54	GO:0003677	DNA binding
0.54	GO:0001105	RNA polymerase II transcription coactivator activity
0.50	GO:0070063	RNA polymerase binding
0.47	GO:0031625	ubiquitin protein ligase binding
0.46	GO:0001067	regulatory region nucleic acid binding
0.40	GO:0003723	RNA binding
0.37	GO:0015631	tubulin binding
0.37	GO:0050681	androgen receptor binding

0.78	GO:0031436	BRCA1-BARD1 complex
0.60	GO:0005694	chromosome
0.53	GO:0070531	BRCA1-A complex
0.43	GO:0031981	nuclear lumen
0.41	GO:0030529	intracellular ribonucleoprotein complex
0.40	GO:0005886	plasma membrane
0.39	GO:0008274	gamma-tubulin ring complex

0.72

KEGG:R03876

GO:0004842

sp|P38405|GNAL_HUMAN
Guanine nucleotide-binding protein G(olf) subunit alpha
Search

GNAL

0.79	Guanine nucleotide binding protein, alpha stimulating, olfactory type

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.51	GO:0019933	cAMP-mediated signaling
0.46	GO:0050877	nervous system process
0.42	GO:0043950	positive regulation of cAMP-mediated signaling
0.41	GO:2000828	regulation of parathyroid hormone secretion
0.41	GO:0030819	positive regulation of cAMP biosynthetic process
0.41	GO:0060789	hair follicle placode formation
0.41	GO:0040032	post-embryonic body morphogenesis
0.40	GO:0045672	positive regulation of osteoclast differentiation
0.40	GO:0001958	endochondral ossification

0.81	GO:0031683	G-protein beta/gamma-subunit complex binding
0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.64	GO:0004871	signal transducer activity
0.48	GO:0001664	G-protein coupled receptor binding
0.40	GO:0035255	ionotropic glutamate receptor binding
0.40	GO:0051428	peptide hormone receptor binding
0.40	GO:0005159	insulin-like growth factor receptor binding
0.37	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity
0.36	GO:0031681	G-protein beta-subunit binding

0.48	GO:1905360	GTPase complex
0.48	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.43	GO:0098797	plasma membrane protein complex
0.39	GO:0030425	dendrite
0.38	GO:0070062	extracellular exosome
0.37	GO:0032588	trans-Golgi network membrane
0.37	GO:0005829	cytosol
0.36	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0042383	sarcolemma
0.36	GO:0001726	ruffle

0.37

EC:3.1.4.39

GO:0047391

sp|P38432|COIL_HUMAN
Coilin
Search

COIL

0.96

Coilin

0.47	GO:0030576	Cajal body organization
0.44	GO:0000387	spliceosomal snRNP assembly
0.38	GO:0055114	oxidation-reduction process

0.81	GO:0008022	protein C-terminus binding
0.72	GO:0042802	identical protein binding
0.44	GO:0015036	disulfide oxidoreductase activity

0.84	GO:0015030	Cajal body
0.80	GO:0001650	fibrillar center
0.50	GO:0001674	female germ cell nucleus
0.37	GO:0071601	sphere organelle
0.30	GO:0016020	membrane

sp|P38435|VKGC_HUMAN
Vitamin K-dependent gamma-carboxylase
Search

GGCX

0.79	Vitamin K-dependent gamma-glutamyl carboxylase

0.85	GO:0017187	peptidyl-glutamic acid carboxylation
0.36	GO:1904016	response to Thyroglobulin triiodothyronine
0.36	GO:0032571	response to vitamin K
0.36	GO:0060437	lung growth
0.36	GO:0010042	response to manganese ion
0.36	GO:0071107	response to parathyroid hormone
0.36	GO:0033280	response to vitamin D
0.36	GO:0071548	response to dexamethasone
0.35	GO:0007596	blood coagulation
0.35	GO:0070482	response to oxygen levels

0.85	GO:0008488	gamma-glutamyl carboxylase activity
0.35	GO:0042277	peptide binding
0.34	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.34	GO:0019842	vitamin binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0004478	methionine adenosyltransferase activity
0.31	GO:0046872	metal ion binding

0.41	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

0.85

EC:4.1.1

GO:0008488

sp|P38484|INGR2_HUMAN
Interferon gamma receptor 2
Search

IFNGR2

0.96	Interferon gamma receptor beta subunit

0.55	GO:0009615	response to virus
0.54	GO:0002252	immune effector process
0.53	GO:0098542	defense response to other organism
0.50	GO:0019221	cytokine-mediated signaling pathway
0.41	GO:0060330	regulation of response to interferon-gamma
0.40	GO:0071346	cellular response to interferon-gamma
0.38	GO:0001959	regulation of cytokine-mediated signaling pathway
0.37	GO:0000398	mRNA splicing, via spliceosome
0.35	GO:0007596	blood coagulation

0.55	GO:0004920	interleukin-10 receptor activity
0.43	GO:0004906	interferon-gamma receptor activity

0.40	GO:0005886	plasma membrane
0.39	GO:0005783	endoplasmic reticulum
0.38	GO:0030659	cytoplasmic vesicle membrane
0.38	GO:0000139	Golgi membrane
0.38	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.37	GO:0005681	spliceosomal complex
0.30	GO:0016021	integral component of membrane

sp|P38567|HYALP_HUMAN
Hyaluronidase PH-20
Search

SPAM1

0.73	Hyaluronidase

0.78	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization
0.60	GO:0005975	carbohydrate metabolic process
0.41	GO:0030214	hyaluronan catabolic process
0.40	GO:0007341	penetration of zona pellucida
0.40	GO:0042117	monocyte activation
0.39	GO:0010764	negative regulation of fibroblast migration
0.39	GO:0060586	multicellular organismal iron ion homeostasis
0.39	GO:2000484	positive regulation of interleukin-8 secretion
0.39	GO:0071493	cellular response to UV-B
0.39	GO:2000778	positive regulation of interleukin-6 secretion

0.85	GO:0004415	hyalurononglucosaminidase activity
0.40	GO:0030294	receptor signaling protein tyrosine kinase inhibitor activity
0.40	GO:0033906	hyaluronoglucuronidase activity
0.39	GO:0104005	hijacked molecular function
0.39	GO:0050431	transforming growth factor beta binding
0.39	GO:0001105	RNA polymerase II transcription coactivator activity
0.38	GO:0030971	receptor tyrosine kinase binding
0.38	GO:0005540	hyaluronic acid binding
0.33	GO:0005525	GTP binding
0.32	GO:0008080	N-acetyltransferase activity

0.43	GO:0031225	anchored component of membrane
0.42	GO:0009897	external side of plasma membrane
0.40	GO:0001669	acrosomal vesicle
0.40	GO:0098589	membrane region
0.38	GO:0005902	microvillus
0.38	GO:0016324	apical plasma membrane
0.38	GO:0030139	endocytic vesicle
0.37	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0005764	lysosome
0.37	GO:0090575	RNA polymerase II transcription factor complex

0.85

EC:3.2.1.35

GO:0004415

sp|P38570|ITAE_HUMAN
Integrin alpha-E
Search

ITGAE

0.97	Integrin subunit alpha E

0.80	GO:0007229	integrin-mediated signaling pathway
0.72	GO:0007155	cell adhesion
0.38	GO:0043315	positive regulation of neutrophil degranulation
0.38	GO:0060376	positive regulation of mast cell differentiation
0.38	GO:2000361	regulation of prostaglandin-E synthase activity
0.38	GO:0032930	positive regulation of superoxide anion generation
0.38	GO:0030198	extracellular matrix organization
0.38	GO:0045963	negative regulation of dopamine metabolic process
0.38	GO:0001781	neutrophil apoptotic process
0.37	GO:0014005	microglia development

0.47	GO:0098639	collagen binding involved in cell-matrix adhesion
0.38	GO:0001851	complement component C3b binding
0.37	GO:0043395	heparan sulfate proteoglycan binding
0.36	GO:0031072	heat shock protein binding
0.36	GO:0008201	heparin binding
0.36	GO:0001540	amyloid-beta binding
0.36	GO:0046982	protein heterodimerization activity
0.35	GO:0038064	collagen receptor activity
0.35	GO:0046872	metal ion binding
0.34	GO:0043236	laminin binding

0.80	GO:0008305	integrin complex
0.62	GO:0009897	external side of plasma membrane
0.37	GO:0044853	plasma membrane raft
0.36	GO:0045178	basal part of cell
0.36	GO:0005615	extracellular space
0.35	GO:1903561	extracellular vesicle
0.35	GO:0005925	focal adhesion
0.34	GO:0005634	nucleus
0.34	GO:0043679	axon terminus
0.34	GO:0005779	integral component of peroxisomal membrane

sp|P38571|LICH_HUMAN
Lysosomal acid lipase/cholesteryl ester hydrolase
Search

LIPA

0.65	Lysosomal acid lipase/cholesteryl ester hydrolase

0.49	GO:0048873	homeostasis of number of cells within a tissue
0.48	GO:0048771	tissue remodeling
0.48	GO:0001816	cytokine production
0.47	GO:0016042	lipid catabolic process
0.47	GO:0030324	lung development
0.46	GO:0006954	inflammatory response
0.46	GO:0008283	cell proliferation
0.44	GO:0000902	cell morphogenesis
0.43	GO:0034383	low-density lipoprotein particle clearance
0.39	GO:0016125	sterol metabolic process

0.59

GO:0016788

hydrolase activity, acting on ester bonds

0.49	GO:0001650	fibrillar center
0.49	GO:0005764	lysosome
0.44	GO:0070062	extracellular exosome
0.42	GO:0005775	vacuolar lumen

0.59

EC:3.1

GO:0016788

sp|P38606|VATA_HUMAN
V-type proton ATPase catalytic subunit A
Search

ATP6V1A

0.92	ATPase H+ transporting V1 subunit A

0.75	GO:0015991	ATP hydrolysis coupled proton transport
0.64	GO:0036295	cellular response to increased oxygen levels
0.62	GO:0046034	ATP metabolic process
0.57	GO:0006875	cellular metal ion homeostasis
0.56	GO:0055072	iron ion homeostasis
0.40	GO:0055078	sodium ion homeostasis
0.39	GO:0030004	cellular monovalent inorganic cation homeostasis
0.39	GO:0055074	calcium ion homeostasis
0.39	GO:0072503	cellular divalent inorganic cation homeostasis

0.80	GO:0046961	proton-transporting ATPase activity, rotational mechanism
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.80	GO:0033180	proton-transporting V-type ATPase, V1 domain
0.68	GO:0016324	apical plasma membrane
0.61	GO:0005902	microvillus
0.60	GO:0043209	myelin sheath
0.52	GO:0005829	cytosol
0.49	GO:0005765	lysosomal membrane
0.47	GO:0005739	mitochondrion
0.37	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

sp|P38646|GRP75_HUMAN
Stress-70 protein, mitochondrial
Search

HSPA9

0.85	LOW QUALITY PROTEIN: stress-70 protein, mitochondrial

0.68	GO:0006457	protein folding
0.63	GO:1902037	negative regulation of hematopoietic stem cell differentiation
0.62	GO:0045647	negative regulation of erythrocyte differentiation
0.59	GO:0030218	erythrocyte differentiation
0.56	GO:0006611	protein export from nucleus
0.53	GO:0016226	iron-sulfur cluster assembly
0.41	GO:0071345	cellular response to cytokine stimulus
0.41	GO:0060548	negative regulation of cell death
0.40	GO:0097068	response to thyroxine
0.40	GO:0070671	response to interleukin-12

0.70	GO:0051082	unfolded protein binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0031625	ubiquitin protein ligase binding
0.39	GO:0017134	fibroblast growth factor binding
0.38	GO:0031072	heat shock protein binding
0.37	GO:0051087	chaperone binding
0.37	GO:0003723	RNA binding

0.54	GO:0042645	mitochondrial nucleoid
0.54	GO:0043209	myelin sheath
0.46	GO:0005730	nucleolus
0.42	GO:0031012	extracellular matrix
0.41	GO:0005925	focal adhesion
0.41	GO:0070062	extracellular exosome

sp|P38919|IF4A3_HUMAN
Eukaryotic initiation factor 4A-III
Search

EIF4A3

0.87	Eukaryotic initiation factor

0.61	GO:0006413	translational initiation
0.53	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.51	GO:0048701	embryonic cranial skeleton morphogenesis
0.48	GO:0006417	regulation of translation
0.48	GO:0034250	positive regulation of cellular amide metabolic process
0.47	GO:0034249	negative regulation of cellular amide metabolic process
0.47	GO:0010501	RNA secondary structure unwinding
0.46	GO:0032270	positive regulation of cellular protein metabolic process
0.46	GO:0008380	RNA splicing
0.46	GO:0010557	positive regulation of macromolecule biosynthetic process

0.65	GO:0004386	helicase activity
0.62	GO:0003743	translation initiation factor activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0008143	poly(A) binding
0.49	GO:0008186	RNA-dependent ATPase activity
0.47	GO:0003729	mRNA binding
0.43	GO:0140098	catalytic activity, acting on RNA

0.51	GO:0071013	catalytic step 2 spliceosome
0.51	GO:0035145	exon-exon junction complex
0.48	GO:0005654	nucleoplasm
0.44	GO:0005730	nucleolus
0.39	GO:0005737	cytoplasm
0.36	GO:0043025	neuronal cell body
0.36	GO:0030425	dendrite
0.30	GO:0016020	membrane

sp|P38935|SMBP2_HUMAN
DNA-binding protein SMUBP-2
Search

IGHMBP2

0.95	Immunoglobulin mu binding protein 2

0.64	GO:0051260	protein homooligomerization
0.58	GO:0032392	DNA geometric change

0.77	GO:0032575	ATP-dependent 5'-3' RNA helicase activity
0.66	GO:0043141	ATP-dependent 5'-3' DNA helicase activity
0.63	GO:0008270	zinc ion binding
0.61	GO:0043022	ribosome binding
0.60	GO:0008134	transcription factor binding
0.57	GO:0000049	tRNA binding
0.55	GO:0030554	adenyl nucleotide binding
0.55	GO:0003677	DNA binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding

0.52	GO:0005634	nucleus
0.43	GO:0005737	cytoplasm

0.66

EC:3.6.1

GO:0043141

sp|P38936|CDN1A_HUMAN
Cyclin-dependent kinase inhibitor 1
Search

CDKN1A

0.91	Cyclin-dependent kinase inhibitor 1

0.84	GO:0072331	signal transduction by p53 class mediator
0.83	GO:0007050	cell cycle arrest
0.82	GO:0071901	negative regulation of protein serine/threonine kinase activity
0.76	GO:0007346	regulation of mitotic cell cycle
0.71	GO:1902400	intracellular signal transduction involved in G1 DNA damage checkpoint
0.70	GO:1904030	negative regulation of cyclin-dependent protein kinase activity
0.70	GO:0071493	cellular response to UV-B
0.70	GO:0042772	DNA damage response, signal transduction resulting in transcription
0.70	GO:0033158	regulation of protein import into nucleus, translocation
0.69	GO:0090399	replicative senescence

0.85	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
0.70	GO:0019912	cyclin-dependent protein kinase activating kinase activity
0.65	GO:0030332	cyclin binding
0.63	GO:0031625	ubiquitin protein ligase binding
0.62	GO:0019901	protein kinase binding
0.61	GO:0032403	protein complex binding
0.43	GO:0004693	cyclin-dependent protein serine/threonine kinase activity
0.36	GO:0046872	metal ion binding
0.35	GO:0003735	structural constituent of ribosome

0.73	GO:0070557	PCNA-p21 complex
0.67	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
0.63	GO:0016604	nuclear body
0.59	GO:0005730	nucleolus
0.56	GO:0005829	cytosol
0.45	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0005840	ribosome

0.70

GO:0019912

sp|P39019|RS19_HUMAN
40S ribosomal protein S19
Search

RPS19

0.55	Ribosomal protein S19

0.60	GO:0006518	peptide metabolic process
0.60	GO:0043604	amide biosynthetic process
0.56	GO:0000028	ribosomal small subunit assembly
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0030218	erythrocyte differentiation
0.54	GO:1901566	organonitrogen compound biosynthetic process
0.54	GO:0010467	gene expression
0.54	GO:0060265	positive regulation of respiratory burst involved in inflammatory response
0.53	GO:0060266	negative regulation of respiratory burst involved in inflammatory response
0.53	GO:0009059	macromolecule biosynthetic process

0.64	GO:0003735	structural constituent of ribosome
0.51	GO:0017134	fibroblast growth factor binding
0.48	GO:0019901	protein kinase binding
0.46	GO:0042803	protein homodimerization activity
0.36	GO:0043565	sequence-specific DNA binding
0.35	GO:0004888	transmembrane signaling receptor activity
0.35	GO:0003700	DNA binding transcription factor activity
0.35	GO:0031369	translation initiation factor binding
0.34	GO:0046872	metal ion binding
0.34	GO:0032403	protein complex binding

0.61	GO:0005840	ribosome
0.50	GO:0044445	cytosolic part
0.46	GO:0005730	nucleolus
0.45	GO:0005654	nucleoplasm
0.36	GO:0031012	extracellular matrix
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.34	GO:0005581	collagen trimer
0.30	GO:0016020	membrane

0.34	EC:1.8.1.9	GO:0004791
0.34	KEGG:R02016	GO:0004791

sp|P39023|RL3_HUMAN
60S ribosomal protein L3
Search

RPL3

0.61	Ribosomal protein L3

0.59	GO:0043043	peptide biosynthetic process
0.54	GO:0044267	cellular protein metabolic process
0.53	GO:0010467	gene expression
0.51	GO:0009059	macromolecule biosynthetic process
0.50	GO:0071353	cellular response to interleukin-4
0.46	GO:0031017	exocrine pancreas development
0.43	GO:0000027	ribosomal large subunit assembly
0.35	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.34	GO:0019083	viral transcription

0.62	GO:0003735	structural constituent of ribosome
0.38	GO:0003723	RNA binding
0.33	GO:0005515	protein binding
0.32	GO:0016787	hydrolase activity

0.60	GO:0005840	ribosome
0.47	GO:0005730	nucleolus
0.46	GO:0005829	cytosol
0.41	GO:0043234	protein complex
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome

0.32

GO:0016787

sp|P39059|COFA1_HUMAN
Collagen alpha-1(XV) chain
Search

COL15A1

0.80	Collagen type XV alpha 1 chain

0.71	GO:0007155	cell adhesion
0.35	GO:1905812	regulation of motor neuron axon guidance
0.34	GO:0048513	animal organ development
0.34	GO:0048864	stem cell development
0.33	GO:0001667	ameboidal-type cell migration
0.33	GO:0009888	tissue development
0.33	GO:0030574	collagen catabolic process
0.33	GO:0001525	angiogenesis
0.32	GO:0007165	signal transduction

0.61

GO:0005198

structural molecule activity

0.77	GO:0005581	collagen trimer
0.73	GO:0031012	extracellular matrix
0.55	GO:0005615	extracellular space
0.39	GO:1903561	extracellular vesicle
0.33	GO:0005788	endoplasmic reticulum lumen
0.30	GO:0016020	membrane

sp|P39060|COIA1_HUMAN
Collagen alpha-1(XVIII) chain
Search

COL18A1

0.75	Collagen type XVIII alpha 1 chain a

0.69	GO:0007155	cell adhesion
0.54	GO:0001886	endothelial cell morphogenesis
0.54	GO:2000353	positive regulation of endothelial cell apoptotic process
0.50	GO:0001525	angiogenesis
0.50	GO:0030335	positive regulation of cell migration
0.50	GO:0030198	extracellular matrix organization
0.49	GO:0008284	positive regulation of cell proliferation
0.47	GO:0001755	neural crest cell migration
0.43	GO:0051599	response to hydrostatic pressure
0.41	GO:0030574	collagen catabolic process

0.60	GO:0005198	structural molecule activity
0.38	GO:0042802	identical protein binding
0.37	GO:0017147	Wnt-protein binding
0.37	GO:0042813	Wnt-activated receptor activity
0.36	GO:0004930	G-protein coupled receptor activity
0.35	GO:0046872	metal ion binding

0.75	GO:0005581	collagen trimer
0.72	GO:0031012	extracellular matrix
0.48	GO:0005615	extracellular space
0.41	GO:1903561	extracellular vesicle
0.40	GO:0005788	endoplasmic reticulum lumen
0.30	GO:0016020	membrane

sp|P39086|GRIK1_HUMAN
Glutamate receptor ionotropic, kainate 1
Search

GRIK1

0.94	Glutamate ionotropic receptor kainate type subunit 1

0.79	GO:0060079	excitatory postsynaptic potential
0.77	GO:0035235	ionotropic glutamate receptor signaling pathway
0.60	GO:0034220	ion transmembrane transport
0.37	GO:0051966	regulation of synaptic transmission, glutamatergic
0.36	GO:0032229	negative regulation of synaptic transmission, GABAergic
0.36	GO:0014054	positive regulation of gamma-aminobutyric acid secretion
0.35	GO:0007399	nervous system development
0.35	GO:0032230	positive regulation of synaptic transmission, GABAergic
0.35	GO:0060080	inhibitory postsynaptic potential
0.35	GO:0048172	regulation of short-term neuronal synaptic plasticity

0.82	GO:0005234	extracellularly glutamate-gated ion channel activity
0.77	GO:0004970	ionotropic glutamate receptor activity
0.36	GO:0099094	ligand-gated cation channel activity
0.36	GO:0005272	sodium channel activity
0.36	GO:0098782	mechanosensitived potassium channel activity
0.35	GO:0016595	glutamate binding
0.34	GO:0022843	voltage-gated cation channel activity
0.34	GO:0042803	protein homodimerization activity
0.32	GO:0008144	drug binding

0.78	GO:0045211	postsynaptic membrane
0.73	GO:0030054	cell junction
0.35	GO:0032983	kainate selective glutamate receptor complex
0.35	GO:0042734	presynaptic membrane
0.35	GO:0043195	terminal bouton
0.35	GO:0014069	postsynaptic density
0.34	GO:0043025	neuronal cell body
0.34	GO:0030425	dendrite

sp|P39210|MPV17_HUMAN
Protein Mpv17
Search

MPV17

0.96	General transcription factor IIIC subunit 2

0.52	GO:0000002	mitochondrial genome maintenance
0.46	GO:0042592	homeostatic process
0.45	GO:0034614	cellular response to reactive oxygen species
0.40	GO:0032836	glomerular basement membrane development
0.39	GO:2000377	regulation of reactive oxygen species metabolic process
0.39	GO:0048839	inner ear development
0.36	GO:0072593	reactive oxygen species metabolic process
0.36	GO:0010469	regulation of receptor activity
0.35	GO:0006067	ethanol metabolic process
0.32	GO:0098656	anion transmembrane transport

0.36	GO:0005179	hormone activity
0.33	GO:0005452	inorganic anion exchanger activity
0.32	GO:0016491	oxidoreductase activity
0.31	GO:0003677	DNA binding

0.45	GO:0005739	mitochondrion
0.44	GO:0019866	organelle inner membrane
0.38	GO:0005777	peroxisome
0.35	GO:0005576	extracellular region
0.32	GO:0000127	transcription factor TFIIIC complex
0.32	GO:0005581	collagen trimer
0.30	GO:0016021	integral component of membrane

0.32

GO:0016491

sp|P39656|OST48_HUMAN
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Search

DDOST

0.78	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

0.85	GO:0018279	protein N-linked glycosylation via asparagine
0.53	GO:0042110	T cell activation
0.51	GO:0034097	response to cytokine
0.38	GO:0006334	nucleosome assembly
0.37	GO:0007018	microtubule-based movement
0.35	GO:0043312	neutrophil degranulation
0.35	GO:0070828	heterochromatin organization
0.32	GO:0006355	regulation of transcription, DNA-templated

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.37	GO:0003777	microtubule motor activity
0.37	GO:0008017	microtubule binding
0.34	GO:0005524	ATP binding
0.34	GO:0003677	DNA binding
0.34	GO:0003682	chromatin binding

0.72	GO:0005789	endoplasmic reticulum membrane
0.43	GO:0043234	protein complex
0.41	GO:1990234	transferase complex
0.37	GO:0000786	nucleosome
0.36	GO:0035577	azurophil granule membrane
0.35	GO:0005634	nucleus
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.65

EC:2.4

GO:0016757

sp|P39687|AN32A_HUMAN
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Search

ANP32A

0.91	Acidic leucine-rich nuclear phosphoprotein 32 family member A

0.71	GO:0006913	nucleocytoplasmic transport
0.68	GO:0043486	histone exchange
0.65	GO:0006334	nucleosome assembly
0.62	GO:0042981	regulation of apoptotic process
0.45	GO:0006351	transcription, DNA-templated
0.44	GO:2001141	regulation of RNA biosynthetic process
0.44	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.44	GO:0010468	regulation of gene expression
0.43	GO:0035067	negative regulation of histone acetylation
0.43	GO:0010977	negative regulation of neuron projection development

0.66	GO:0042393	histone binding
0.43	GO:0005178	integrin binding
0.42	GO:0008022	protein C-terminus binding
0.40	GO:0003723	RNA binding

0.74	GO:0048471	perinuclear region of cytoplasm
0.66	GO:0005783	endoplasmic reticulum
0.61	GO:0005634	nucleus
0.49	GO:0031974	membrane-enclosed lumen
0.44	GO:0044446	intracellular organelle part
0.39	GO:0005829	cytosol

sp|P39748|FEN1_HUMAN
Flap endonuclease 1
Search

FEN1

0.64	Flap endonuclease 1

0.81	GO:0043137	DNA replication, removal of RNA primer
0.69	GO:0006284	base-excision repair
0.64	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.58	GO:0045876	positive regulation of sister chromatid cohesion
0.39	GO:0007613	memory
0.35	GO:0032201	telomere maintenance via semi-conservative replication
0.35	GO:0009650	UV protection
0.34	GO:0060041	retina development in camera-type eye
0.34	GO:0000724	double-strand break repair via homologous recombination
0.34	GO:0030262	apoptotic nuclear changes

0.79	GO:0017108	5'-flap endonuclease activity
0.74	GO:0008409	5'-3' exonuclease activity
0.62	GO:0000287	magnesium ion binding
0.55	GO:0003677	DNA binding
0.50	GO:0004523	RNA-DNA hybrid ribonuclease activity
0.35	GO:0030145	manganese ion binding
0.35	GO:0008309	double-stranded DNA exodeoxyribonuclease activity
0.33	GO:0005515	protein binding
0.33	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.33	GO:0003700	DNA binding transcription factor activity

0.72	GO:0005730	nucleolus
0.68	GO:0005654	nucleoplasm
0.60	GO:0005739	mitochondrion
0.54	GO:0000784	nuclear chromosome, telomeric region
0.44	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

0.50

EC:3.1.26.4

GO:0004523

sp|P39877|PA2G5_HUMAN
Calcium-dependent phospholipase A2
Search

PLA2G5

0.63	Vaspin basic subunit variant

0.82	GO:0050482	arachidonic acid secretion
0.72	GO:0016042	lipid catabolic process
0.67	GO:0006644	phospholipid metabolic process
0.55	GO:0010518	positive regulation of phospholipase activity
0.53	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.48	GO:0009405	pathogenesis
0.40	GO:0019370	leukotriene biosynthetic process
0.40	GO:0051591	response to cAMP
0.38	GO:0034097	response to cytokine
0.38	GO:0034374	low-density lipoprotein particle remodeling

0.82	GO:0004623	phospholipase A2 activity
0.76	GO:0102568	phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
0.76	GO:0102567	phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
0.70	GO:0005509	calcium ion binding
0.51	GO:0090729	toxin activity
0.39	GO:0008201	heparin binding
0.36	GO:0005102	receptor binding
0.33	GO:0030545	receptor regulator activity
0.32	GO:0016301	kinase activity

0.66	GO:0005576	extracellular region
0.47	GO:0072556	other organism presynaptic membrane
0.38	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0005794	Golgi apparatus
0.37	GO:0035792	other organism postsynaptic membrane
0.36	GO:0009986	cell surface
0.35	GO:0005886	plasma membrane
0.32	GO:0018995	host

0.82

EC:3.1.1.4

GO:0004623

sp|P39880|CUX1_HUMAN
Homeobox protein cut-like 1
Search

0.65	Homeobox protein cut-like

0.58	GO:0006891	intra-Golgi vesicle-mediated transport
0.52	GO:0006351	transcription, DNA-templated
0.52	GO:1903506	regulation of nucleic acid-templated transcription
0.52	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.52	GO:0010468	regulation of gene expression
0.42	GO:1902679	negative regulation of RNA biosynthetic process
0.42	GO:0007275	multicellular organism development
0.41	GO:1900006	positive regulation of dendrite development
0.41	GO:0060563	neuroepithelial cell differentiation
0.40	GO:0010770	positive regulation of cell morphogenesis involved in differentiation

0.56	GO:0043565	sequence-specific DNA binding
0.44	GO:0001012	RNA polymerase II regulatory region DNA binding
0.42	GO:0003690	double-stranded DNA binding
0.41	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
0.40	GO:0030674	protein binding, bridging
0.39	GO:0003682	chromatin binding
0.30	GO:0004713	protein tyrosine kinase activity

0.59	GO:0005794	Golgi apparatus
0.56	GO:0005634	nucleus
0.54	GO:0031301	integral component of organelle membrane
0.54	GO:0098588	bounding membrane of organelle
0.52	GO:0031984	organelle subcompartment
0.46	GO:0031974	membrane-enclosed lumen
0.39	GO:0043005	neuron projection
0.30	GO:0005829	cytosol

0.30

GO:0004713

sp|P39900|MMP12_HUMAN
Macrophage metalloelastase
Search

MMP12

0.56	Macrophage metalloelastase

0.61	GO:0042060	wound healing
0.61	GO:0006508	proteolysis
0.57	GO:1902741	positive regulation of interferon-alpha secretion
0.56	GO:0060340	positive regulation of type I interferon-mediated signaling pathway
0.55	GO:0090504	epiboly
0.55	GO:0050691	regulation of defense response to virus by host
0.54	GO:0050679	positive regulation of epithelial cell proliferation
0.54	GO:0098586	cellular response to virus
0.52	GO:0006606	protein import into nucleus
0.52	GO:0016477	cell migration

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.53	GO:0005518	collagen binding
0.53	GO:0001047	core promoter binding
0.48	GO:0005509	calcium ion binding
0.45	GO:0043565	sequence-specific DNA binding
0.38	GO:0004252	serine-type endopeptidase activity

0.74	GO:0031012	extracellular matrix
0.50	GO:0005615	extracellular space
0.44	GO:0005634	nucleus
0.39	GO:0005737	cytoplasm
0.37	GO:0005581	collagen trimer
0.36	GO:0031312	extrinsic component of organelle membrane
0.35	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.35	GO:0031984	organelle subcompartment
0.32	GO:0009897	external side of plasma membrane
0.32	GO:0030425	dendrite

0.70

GO:0004222

sp|P39905|GDNF_HUMAN
Glial cell line-derived neurotrophic factor
Search

GDNF

0.97	Glial cell line-derived neurotrophic factor

0.75	GO:0010469	regulation of receptor activity
0.62	GO:0021784	postganglionic parasympathetic fiber development
0.62	GO:0072107	positive regulation of ureteric bud formation
0.61	GO:0051940	regulation of catecholamine uptake involved in synaptic transmission
0.61	GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
0.60	GO:0032225	regulation of synaptic transmission, dopaminergic
0.60	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
0.60	GO:0060676	ureteric bud formation
0.60	GO:0030432	peristalsis
0.60	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis

0.78	GO:0008083	growth factor activity
0.53	GO:0042803	protein homodimerization activity
0.37	GO:0030116	glial cell-derived neurotrophic factor receptor binding
0.36	GO:0019899	enzyme binding
0.35	GO:0005160	transforming growth factor beta receptor binding

0.66	GO:0005576	extracellular region
0.35	GO:0043235	receptor complex
0.32	GO:0005622	intracellular
0.30	GO:0016020	membrane

sp|P40121|CAPG_HUMAN
Macrophage-capping protein
Search

CAPG

0.97	Capping actin protein, gelsolin like

0.84	GO:0051016	barbed-end actin filament capping
0.53	GO:0051014	actin filament severing
0.52	GO:0031334	positive regulation of protein complex assembly
0.51	GO:0010638	positive regulation of organelle organization
0.51	GO:1902905	positive regulation of supramolecular fiber organization
0.49	GO:0007015	actin filament organization
0.40	GO:0071801	regulation of podosome assembly
0.40	GO:0071346	cellular response to interferon-gamma
0.38	GO:0030031	cell projection assembly
0.38	GO:0022617	extracellular matrix disassembly

0.78	GO:0051015	actin filament binding
0.55	GO:0045296	cadherin binding
0.52	GO:0019904	protein domain specific binding
0.47	GO:0005509	calcium ion binding
0.37	GO:0045159	myosin II binding
0.33	GO:0004181	metallocarboxypeptidase activity
0.32	GO:0008270	zinc ion binding

0.58	GO:0090543	Flemming body
0.55	GO:0005814	centriole
0.54	GO:0072686	mitotic spindle
0.51	GO:0005730	nucleolus
0.49	GO:0005654	nucleoplasm
0.40	GO:0042470	melanosome
0.39	GO:0045335	phagocytic vesicle
0.39	GO:0005615	extracellular space
0.37	GO:0030478	actin cap
0.37	GO:1903561	extracellular vesicle

0.33

EC:3.4.17

GO:0004181

sp|P40123|CAP2_HUMAN
Adenylyl cyclase-associated protein 2
Search

CAP2

0.74	Adenylyl cyclase-associated protein 2

0.71	GO:0007010	cytoskeleton organization
0.57	GO:0030029	actin filament-based process
0.51	GO:0000902	cell morphogenesis
0.50	GO:0045761	regulation of adenylate cyclase activity
0.49	GO:0007163	establishment or maintenance of cell polarity
0.46	GO:0097435	supramolecular fiber organization
0.46	GO:0001667	ameboidal-type cell migration
0.43	GO:0006898	receptor-mediated endocytosis
0.42	GO:0007165	signal transduction
0.37	GO:0007190	activation of adenylate cyclase activity

0.74	GO:0003779	actin binding
0.53	GO:0008179	adenylate cyclase binding
0.50	GO:0042802	identical protein binding
0.33	GO:0003735	structural constituent of ribosome
0.33	GO:0003723	RNA binding

0.55	GO:0014069	postsynaptic density
0.53	GO:0030864	cortical actin cytoskeleton
0.43	GO:0005615	extracellular space
0.36	GO:0005886	plasma membrane
0.35	GO:0035578	azurophil granule lumen
0.34	GO:0005925	focal adhesion
0.34	GO:1903561	extracellular vesicle
0.33	GO:0015934	large ribosomal subunit

sp|P40126|TYRP2_HUMAN
L-dopachrome tautomerase
Search

DCT

0.97	L-dopachrome tautomerase variant

0.61	GO:0006583	melanin biosynthetic process from tyrosine
0.60	GO:0021847	ventricular zone neuroblast division
0.58	GO:0002052	positive regulation of neuroblast proliferation
0.56	GO:0048066	developmental pigmentation
0.52	GO:0055114	oxidation-reduction process
0.51	GO:0048468	cell development
0.35	GO:0008544	epidermis development

0.61	GO:0004167	dopachrome isomerase activity
0.53	GO:0016491	oxidoreductase activity
0.53	GO:0046872	metal ion binding

0.57	GO:0042470	melanosome
0.48	GO:0005829	cytosol
0.42	GO:0090741	pigment granule membrane
0.42	GO:0045009	chitosome
0.39	GO:0030659	cytoplasmic vesicle membrane
0.38	GO:0098805	whole membrane
0.30	GO:0016021	integral component of membrane

0.61	EC:5.3.3.12	GO:0004167
0.61	KEGG:R03673	GO:0004167

sp|P40145|ADCY8_HUMAN
Adenylate cyclase type 8
Search

ADCY8

0.94	LOW QUALITY PROTEIN: adenylate cyclase type 8

0.76	GO:0006171	cAMP biosynthetic process
0.62	GO:0035556	intracellular signal transduction
0.58	GO:0007616	long-term memory
0.49	GO:0006182	cGMP biosynthetic process
0.44	GO:0016199	axon midline choice point recognition
0.44	GO:0031290	retinal ganglion cell axon guidance
0.38	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
0.37	GO:0034199	activation of protein kinase A activity
0.37	GO:0071377	cellular response to glucagon stimulus
0.37	GO:0003091	renal water homeostasis

0.77	GO:0004016	adenylate cyclase activity
0.52	GO:1901265	nucleoside phosphate binding
0.50	GO:0036094	small molecule binding
0.49	GO:0004383	guanylate cyclase activity
0.48	GO:0097367	carbohydrate derivative binding
0.48	GO:0008144	drug binding
0.47	GO:0043168	anion binding
0.36	GO:0047485	protein N-terminus binding
0.36	GO:0008022	protein C-terminus binding
0.35	GO:0005516	calmodulin binding

0.54	GO:0005886	plasma membrane
0.51	GO:0008074	guanylate cyclase complex, soluble
0.30	GO:0016021	integral component of membrane

0.77

EC:4.6.1.1

GO:0004016

sp|P40189|IL6RB_HUMAN
Interleukin-6 receptor subunit beta
Search

IL6ST

0.96	Interleukin-6 receptor subunit beta

0.76	GO:0019221	cytokine-mediated signaling pathway
0.65	GO:0048861	leukemia inhibitory factor signaling pathway
0.63	GO:0071354	cellular response to interleukin-6
0.63	GO:0048711	positive regulation of astrocyte differentiation
0.62	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
0.61	GO:0045669	positive regulation of osteoblast differentiation
0.61	GO:0042102	positive regulation of T cell proliferation
0.59	GO:0008593	regulation of Notch signaling pathway
0.54	GO:0005977	glycogen metabolic process
0.41	GO:0070104	negative regulation of interleukin-6-mediated signaling pathway

0.78	GO:0004896	cytokine receptor activity
0.66	GO:0019981	interleukin-6 binding
0.66	GO:0019970	interleukin-11 binding
0.65	GO:0005127	ciliary neurotrophic factor receptor binding
0.63	GO:0005138	interleukin-6 receptor binding
0.36	GO:0046983	protein dimerization activity
0.35	GO:0042802	identical protein binding

0.65	GO:0005900	oncostatin-M receptor complex
0.65	GO:0005896	interleukin-6 receptor complex
0.65	GO:0070110	ciliary neurotrophic factor receptor complex
0.58	GO:0009897	external side of plasma membrane
0.58	GO:0043025	neuronal cell body
0.58	GO:0030425	dendrite
0.38	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.36	GO:0044298	cell body membrane

sp|P40197|GPV_HUMAN
Platelet glycoprotein V
Search

GP5

0.91	Platelet glycoprotein V

0.54	GO:0007409	axonogenesis
0.48	GO:0007596	blood coagulation
0.46	GO:0010544	negative regulation of platelet activation
0.45	GO:0007155	cell adhesion
0.42	GO:0072376	protein activation cascade
0.41	GO:0001775	cell activation
0.38	GO:0006468	protein phosphorylation
0.37	GO:1903077	negative regulation of protein localization to plasma membrane
0.37	GO:0046813	receptor-mediated virion attachment to host cell
0.36	GO:0030335	positive regulation of cell migration

0.45	GO:0005518	collagen binding
0.38	GO:0004672	protein kinase activity
0.37	GO:0001968	fibronectin binding
0.37	GO:0043236	laminin binding
0.37	GO:0030554	adenyl nucleotide binding
0.37	GO:0097367	carbohydrate derivative binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0008144	drug binding
0.36	GO:0005044	scavenger receptor activity
0.34	GO:0016887	ATPase activity

0.52	GO:0005578	proteinaceous extracellular matrix
0.52	GO:0005615	extracellular space
0.45	GO:1903561	extracellular vesicle
0.42	GO:0009986	cell surface
0.39	GO:0036454	growth factor complex
0.38	GO:0005887	integral component of plasma membrane
0.36	GO:0005654	nucleoplasm
0.34	GO:0000164	protein phosphatase type 1 complex
0.33	GO:0030015	CCR4-NOT core complex
0.33	GO:0000932	P-body

0.34	EC:3.6.1.3	GO:0016887
0.34	KEGG:R03532	GO:0004601

sp|P40198|CEAM3_HUMAN
Carcinoembryonic antigen-related cell adhesion molecule 3
Search

CEACAM4

0.95	Carcinoembryonic antigen-related cell adhesion molecule 3

0.55	GO:0007565	female pregnancy
0.47	GO:0016477	cell migration
0.45	GO:0043312	neutrophil degranulation
0.44	GO:0043317	regulation of cytotoxic T cell degranulation
0.44	GO:0006909	phagocytosis
0.43	GO:0002859	negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
0.43	GO:0001915	negative regulation of T cell mediated cytotoxicity
0.43	GO:0030334	regulation of cell migration
0.42	GO:0043301	negative regulation of leukocyte degranulation
0.42	GO:0050860	negative regulation of T cell receptor signaling pathway

0.42	GO:0031005	filamin binding
0.41	GO:1990782	protein tyrosine kinase binding
0.41	GO:0019903	protein phosphatase binding
0.41	GO:0042803	protein homodimerization activity
0.39	GO:0003779	actin binding
0.37	GO:0034235	GPI anchor binding
0.37	GO:0015125	bile acid transmembrane transporter activity
0.36	GO:0005516	calmodulin binding

0.47	GO:0005576	extracellular region
0.44	GO:0035579	specific granule membrane
0.42	GO:0042101	T cell receptor complex
0.41	GO:0009986	cell surface
0.40	GO:0035577	azurophil granule membrane
0.40	GO:0070821	tertiary granule membrane
0.40	GO:0031225	anchored component of membrane
0.40	GO:0005887	integral component of plasma membrane
0.39	GO:0005911	cell-cell junction
0.39	GO:0016323	basolateral plasma membrane

sp|P40199|CEAM6_HUMAN
Carcinoembryonic antigen-related cell adhesion molecule 6
Search

0.86	Pregnancy specific beta-1-glycoprotein 2

0.50	GO:0007565	female pregnancy
0.47	GO:0016477	cell migration
0.47	GO:0043317	regulation of cytotoxic T cell degranulation
0.46	GO:0002859	negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
0.45	GO:0001915	negative regulation of T cell mediated cytotoxicity
0.45	GO:0030334	regulation of cell migration
0.45	GO:0043301	negative regulation of leukocyte degranulation
0.44	GO:0043312	neutrophil degranulation
0.44	GO:0050860	negative regulation of T cell receptor signaling pathway
0.44	GO:0090505	epiboly involved in wound healing

0.45	GO:0031005	filamin binding
0.44	GO:1990782	protein tyrosine kinase binding
0.44	GO:0019903	protein phosphatase binding
0.43	GO:0042803	protein homodimerization activity
0.41	GO:0003779	actin binding
0.40	GO:0015125	bile acid transmembrane transporter activity
0.38	GO:0005516	calmodulin binding
0.38	GO:0034235	GPI anchor binding
0.37	GO:0005130	granulocyte colony-stimulating factor receptor binding
0.36	GO:0046790	virion binding

0.48	GO:0005615	extracellular space
0.45	GO:0042101	T cell receptor complex
0.43	GO:0030667	secretory granule membrane
0.43	GO:0009986	cell surface
0.42	GO:0031225	anchored component of membrane
0.42	GO:1903561	extracellular vesicle
0.42	GO:0005911	cell-cell junction
0.42	GO:0042581	specific granule
0.41	GO:0042582	azurophil granule
0.41	GO:0016323	basolateral plasma membrane

sp|P40200|TACT_HUMAN
T-cell surface protein tactile
Search

CD96

0.96	T-cell surface protein tactile

0.69	GO:0002728	negative regulation of natural killer cell cytokine production
0.67	GO:0002534	cytokine production involved in inflammatory response
0.64	GO:0032689	negative regulation of interferon-gamma production
0.63	GO:0007160	cell-matrix adhesion
0.60	GO:0032496	response to lipopolysaccharide
0.39	GO:0006955	immune response
0.33	GO:0002857	positive regulation of natural killer cell mediated immune response to tumor cell
0.33	GO:0002858	regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
0.33	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
0.33	GO:0007286	spermatid development

0.35	GO:0005515	protein binding
0.32	GO:0004872	receptor activity

0.62	GO:0005912	adherens junction
0.42	GO:0005737	cytoplasm
0.37	GO:0005887	integral component of plasma membrane
0.33	GO:0005911	cell-cell junction

sp|P40205|NCYM_HUMAN
N-cym protein
Search

0.81	GO:0033673	negative regulation of kinase activity
0.79	GO:0031647	regulation of protein stability
0.79	GO:0008284	positive regulation of cell proliferation
0.78	GO:0043066	negative regulation of apoptotic process
0.70	GO:0007275	multicellular organism development

0.63

GO:0005515

protein binding

0.61	GO:0005634	nucleus
0.49	GO:0005737	cytoplasm

sp|P40222|TXLNA_HUMAN
Alpha-taxilin
Search

TXLNA

0.87	LOW QUALITY PROTEIN: alpha-taxilin

0.58	GO:0042113	B cell activation
0.44	GO:0030500	regulation of bone mineralization
0.41	GO:0010564	regulation of cell cycle process
0.36	GO:0006887	exocytosis
0.35	GO:0008283	cell proliferation
0.35	GO:0019221	cytokine-mediated signaling pathway
0.35	GO:0010469	regulation of receptor activity
0.34	GO:0006606	protein import into nucleus
0.34	GO:0001731	formation of translation preinitiation complex
0.34	GO:0006446	regulation of translational initiation

0.84	GO:0019905	syntaxin binding
0.41	GO:0046982	protein heterodimerization activity
0.37	GO:0030372	high molecular weight B cell growth factor receptor binding
0.35	GO:0005125	cytokine activity
0.35	GO:0061608	nuclear import signal receptor activity
0.34	GO:0003743	translation initiation factor activity
0.34	GO:0008565	protein transporter activity

0.42	GO:0031965	nuclear membrane
0.41	GO:0005737	cytoplasm
0.34	GO:0005576	extracellular region
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0043234	protein complex

sp|P40225|TPO_HUMAN
Thrombopoietin
Search

THPO

0.97	Thrombopoietin

0.80	GO:0008283	cell proliferation
0.78	GO:0038163	thrombopoietin-mediated signaling pathway
0.76	GO:0045654	positive regulation of megakaryocyte differentiation
0.76	GO:1902035	positive regulation of hematopoietic stem cell proliferation
0.76	GO:0010469	regulation of receptor activity
0.72	GO:0051897	positive regulation of protein kinase B signaling
0.70	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.68	GO:0030099	myeloid cell differentiation
0.38	GO:0071222	cellular response to lipopolysaccharide

0.81	GO:0005125	cytokine activity
0.79	GO:0005179	hormone activity
0.39	GO:0008083	growth factor activity

0.66

GO:0005576

extracellular region

sp|P40227|TCPZ_HUMAN
T-complex protein 1 subunit zeta
Search

CCT6A

0.90	Chaperonin containing TCP1 subunit 6A

0.69	GO:0006457	protein folding
0.55	GO:1901998	toxin transport
0.53	GO:1904869	regulation of protein localization to Cajal body
0.52	GO:1904851	positive regulation of establishment of protein localization to telomere
0.52	GO:1904874	positive regulation of telomerase RNA localization to Cajal body
0.51	GO:0032212	positive regulation of telomere maintenance via telomerase
0.50	GO:1900182	positive regulation of protein localization to nucleus
0.48	GO:0050821	protein stabilization
0.37	GO:0007339	binding of sperm to zona pellucida

0.71	GO:0051082	unfolded protein binding
0.59	GO:0044183	protein binding involved in protein folding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0071987	WD40-repeat domain binding
0.34	GO:0003723	RNA binding

0.65	GO:0005832	chaperonin-containing T-complex
0.46	GO:0005874	microtubule
0.38	GO:0002199	zona pellucida receptor complex
0.37	GO:0001669	acrosomal vesicle
0.37	GO:0070062	extracellular exosome
0.37	GO:0044297	cell body
0.36	GO:0031012	extracellular matrix
0.30	GO:0016020	membrane

sp|P40238|TPOR_HUMAN
Thrombopoietin receptor
Search

MPL

0.97	Myeloproliferative leukemia virus oncogene

0.79	GO:0019221	cytokine-mediated signaling pathway
0.51	GO:1905221	positive regulation of platelet formation
0.51	GO:1990959	eosinophil homeostasis
0.51	GO:1990960	basophil homeostasis
0.50	GO:0035702	monocyte homeostasis
0.50	GO:2000035	regulation of stem cell division
0.49	GO:0030220	platelet formation
0.49	GO:0060216	definitive hemopoiesis
0.48	GO:0072091	regulation of stem cell proliferation
0.48	GO:0032642	regulation of chemokine production

0.80	GO:0004896	cytokine receptor activity
0.36	GO:0005515	protein binding
0.36	GO:0097027	ubiquitin-protein transferase activator activity
0.34	GO:0044877	macromolecular complex binding

0.62	GO:0009986	cell surface
0.59	GO:0005794	Golgi apparatus
0.45	GO:0043025	neuronal cell body
0.44	GO:0043005	neuron projection
0.39	GO:0005886	plasma membrane
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

sp|P40259|CD79B_HUMAN
B-cell antigen receptor complex-associated protein beta chain
Search

CD79B

0.97	B-cell antigen receptor complex-associated protein beta chain

0.69	GO:0050853	B cell receptor signaling pathway
0.62	GO:0051260	protein homooligomerization
0.54	GO:0030183	B cell differentiation
0.41	GO:0002250	adaptive immune response
0.37	GO:0035725	sodium ion transmembrane transport
0.36	GO:0010469	regulation of receptor activity
0.35	GO:0034765	regulation of ion transmembrane transport

0.66	GO:0004888	transmembrane signaling receptor activity
0.60	GO:0042803	protein homodimerization activity
0.38	GO:0005248	voltage-gated sodium channel activity
0.37	GO:0005179	hormone activity
0.35	GO:0005131	growth hormone receptor binding
0.34	GO:0005244	voltage-gated ion channel activity

0.73	GO:0019815	B cell receptor complex
0.66	GO:0009897	external side of plasma membrane
0.58	GO:0005794	Golgi apparatus
0.57	GO:0005654	nucleoplasm
0.56	GO:0005829	cytosol
0.47	GO:0005887	integral component of plasma membrane
0.41	GO:0070062	extracellular exosome
0.37	GO:0034706	sodium channel complex

sp|P40261|NNMT_HUMAN
Nicotinamide N-methyltransferase
Search

NNMT

0.89	Indolethylamine N-methyltransferase

0.63	GO:0032259	methylation
0.42	GO:0031100	animal organ regeneration
0.40	GO:0010243	response to organonitrogen compound
0.38	GO:0042493	response to drug
0.38	GO:0042418	epinephrine biosynthetic process
0.37	GO:0009308	amine metabolic process
0.36	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway
0.36	GO:0009636	response to toxic substance
0.34	GO:0035900	response to isolation stress
0.34	GO:0035902	response to immobilization stress

0.63	GO:0008168	methyltransferase activity
0.33	GO:0005515	protein binding

0.50	GO:0005829	cytosol
0.34	GO:0043196	varicosity
0.34	GO:0043204	perikaryon
0.34	GO:0043195	terminal bouton
0.33	GO:0030425	dendrite
0.32	GO:0005634	nucleus

0.63

GO:0008168

sp|P40305|IFI27_HUMAN
Interferon alpha-inducible protein 27, mitochondrial
Search

0.94	Interferon alpha inducible protein 6

0.45	GO:0051902	negative regulation of mitochondrial depolarization
0.44	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.44	GO:0001836	release of cytochrome c from mitochondria
0.43	GO:1901099	negative regulation of signal transduction in absence of ligand
0.43	GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand
0.43	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
0.43	GO:2000117	negative regulation of cysteine-type endopeptidase activity
0.38	GO:0060337	type I interferon signaling pathway
0.38	GO:0046825	regulation of protein export from nucleus
0.37	GO:2001056	positive regulation of cysteine-type endopeptidase activity

0.38	GO:0005521	lamin binding
0.38	GO:0001102	RNA polymerase II activating transcription factor binding
0.35	GO:0003796	lysozyme activity
0.32	GO:0003677	DNA binding

0.38	GO:0005739	mitochondrion
0.37	GO:0005637	nuclear inner membrane
0.35	GO:0031968	organelle outer membrane
0.33	GO:0015630	microtubule cytoskeleton
0.32	GO:0005840	ribosome
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.35

EC:3.2.1.17

GO:0003796

sp|P40306|PSB10_HUMAN
Proteasome subunit beta type-10
Search

PSMB10

0.53	Proteasome subunit beta type

0.72	GO:0051603	proteolysis involved in cellular protein catabolic process
0.62	GO:0002376	immune system process
0.55	GO:0032943	mononuclear cell proliferation
0.52	GO:0001775	cell activation
0.50	GO:0000902	cell morphogenesis
0.37	GO:0043632	modification-dependent macromolecule catabolic process
0.36	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.36	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.36	GO:0038095	Fc-epsilon receptor signaling pathway
0.36	GO:1902036	regulation of hematopoietic stem cell differentiation

0.77	GO:0070003	threonine-type peptidase activity
0.65	GO:0004175	endopeptidase activity
0.33	GO:0005515	protein binding

0.76	GO:0005839	proteasome core complex
0.60	GO:0005634	nucleus
0.58	GO:1990111	spermatoproteasome complex
0.48	GO:0005737	cytoplasm
0.35	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part
0.30	GO:0044425	membrane part

sp|P40313|CTRL_HUMAN
Chymotrypsin-like protease CTRL-1
Search

CTRL

0.90	Chymotrypsinogen I

0.61	GO:0006508	proteolysis
0.42	GO:0007586	digestion
0.36	GO:0022617	extracellular matrix disassembly
0.34	GO:0030163	protein catabolic process
0.34	GO:0009235	cobalamin metabolic process
0.34	GO:0032094	response to food
0.34	GO:0007584	response to nutrient
0.34	GO:0043434	response to peptide hormone
0.34	GO:0007596	blood coagulation
0.34	GO:0043065	positive regulation of apoptotic process

0.69	GO:0004252	serine-type endopeptidase activity
0.34	GO:0070003	threonine-type peptidase activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0005515	protein binding

0.39	GO:0005615	extracellular space
0.34	GO:0005839	proteasome core complex
0.34	GO:0005764	lysosome
0.33	GO:0005634	nucleus

0.69

GO:0004252

sp|P40337|VHL_HUMAN
Von Hippel-Lindau disease tumor suppressor
Search

VHL

0.95	von Hippel-Lindau disease tumor suppressor

0.81	GO:1902072	negative regulation of hypoxia-inducible factor-1alpha signaling pathway
0.81	GO:0048877	homeostasis of number of retina cells
0.78	GO:0061073	ciliary body morphogenesis
0.77	GO:0070244	negative regulation of thymocyte apoptotic process
0.77	GO:0061072	iris morphogenesis
0.77	GO:0045602	negative regulation of endothelial cell differentiation
0.77	GO:0003310	pancreatic A cell differentiation
0.75	GO:0043534	blood vessel endothelial cell migration
0.75	GO:0048069	eye pigmentation
0.74	GO:0003309	type B pancreatic cell differentiation

0.66	GO:0032403	protein complex binding
0.63	GO:0061630	ubiquitin protein ligase activity
0.52	GO:0008134	transcription factor binding
0.52	GO:0019899	enzyme binding
0.37	GO:0042803	protein homodimerization activity
0.37	GO:0046982	protein heterodimerization activity
0.37	GO:0004984	olfactory receptor activity
0.36	GO:0004674	protein serine/threonine kinase activity
0.36	GO:0004930	G-protein coupled receptor activity
0.34	GO:0016874	ligase activity

0.75	GO:0031462	Cul2-RING ubiquitin ligase complex
0.69	GO:0030891	VCB complex
0.65	GO:0005929	cilium
0.63	GO:0005654	nucleoplasm
0.63	GO:0005730	nucleolus
0.44	GO:0031209	SCAR complex
0.43	GO:0005829	cytosol
0.40	GO:0005739	mitochondrion
0.38	GO:0005783	endoplasmic reticulum
0.38	GO:0005667	transcription factor complex

0.36

GO:0004674

sp|P40394|ADH7_HUMAN
Alcohol dehydrogenase class 4 mu/sigma chain
Search

ADH7

0.68	Alcohol dehydrogenase E chain

0.53	GO:0006068	ethanol catabolic process
0.53	GO:0010430	fatty acid omega-oxidation
0.52	GO:0006069	ethanol oxidation
0.51	GO:0042573	retinoic acid metabolic process
0.51	GO:0045471	response to ethanol
0.51	GO:0042572	retinol metabolic process
0.50	GO:1900116	extracellular negative regulation of signal transduction
0.47	GO:0009617	response to bacterium
0.39	GO:0033574	response to testosterone
0.38	GO:0032526	response to retinoic acid

0.62	GO:0008270	zinc ion binding
0.58	GO:0004022	alcohol dehydrogenase (NAD) activity
0.52	GO:0035276	ethanol binding
0.52	GO:0004745	retinol dehydrogenase activity
0.52	GO:0004031	aldehyde oxidase activity
0.52	GO:0019841	retinol binding
0.51	GO:0048019	receptor antagonist activity
0.38	GO:0042803	protein homodimerization activity
0.34	GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase activity
0.34	GO:0051287	NAD binding

0.48	GO:0005829	cytosol
0.43	GO:0005576	extracellular region
0.42	GO:0005886	plasma membrane
0.41	GO:0005654	nucleoplasm
0.35	GO:0005739	mitochondrion
0.34	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)
0.33	GO:0019866	organelle inner membrane
0.33	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.58	EC:1.1.1.1	GO:0004022
0.34	KEGG:R06983 KEGG:R07140	GO:0051903

sp|P40424|PBX1_HUMAN
Pre-B-cell leukemia transcription factor 1
Search

PBX1

0.94	Pre-B-cell leukemia transcription factor 1

0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:0010468	regulation of gene expression
0.54	GO:0030325	adrenal gland development
0.54	GO:0048536	spleen development
0.53	GO:0001658	branching involved in ureteric bud morphogenesis
0.53	GO:0009954	proximal/distal pattern formation
0.53	GO:0048538	thymus development
0.53	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
0.53	GO:0035162	embryonic hemopoiesis

0.64	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.51	GO:0001012	RNA polymerase II regulatory region DNA binding
0.48	GO:0046982	protein heterodimerization activity
0.48	GO:0003690	double-stranded DNA binding
0.38	GO:0008134	transcription factor binding

0.61	GO:0005634	nucleus
0.50	GO:0005667	transcription factor complex
0.46	GO:0031974	membrane-enclosed lumen
0.42	GO:0044446	intracellular organelle part
0.38	GO:0005737	cytoplasm
0.34	GO:0030496	midbody
0.30	GO:0016020	membrane

sp|P40425|PBX2_HUMAN
Pre-B-cell leukemia transcription factor 2
Search

PBX2

0.91	Pre-B-cell leukemia transcription factor 2

0.58	GO:0009954	proximal/distal pattern formation
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:0030326	embryonic limb morphogenesis
0.56	GO:0010468	regulation of gene expression
0.54	GO:0051254	positive regulation of RNA metabolic process
0.53	GO:0010557	positive regulation of macromolecule biosynthetic process
0.53	GO:0031328	positive regulation of cellular biosynthetic process
0.45	GO:0006366	transcription by RNA polymerase II
0.45	GO:0007399	nervous system development

0.64	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.56	GO:0001012	RNA polymerase II regulatory region DNA binding
0.53	GO:0003690	double-stranded DNA binding
0.51	GO:0003682	chromatin binding
0.48	GO:0008134	transcription factor binding
0.43	GO:0035326	enhancer binding
0.41	GO:0046982	protein heterodimerization activity
0.34	GO:0005509	calcium ion binding
0.34	GO:0004872	receptor activity

0.61	GO:0005634	nucleus
0.55	GO:0005667	transcription factor complex
0.40	GO:0043233	organelle lumen
0.37	GO:0044446	intracellular organelle part
0.35	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|P40426|PBX3_HUMAN
Pre-B-cell leukemia transcription factor 3
Search

PBX3

0.90	PBX homeobox 3

0.71	GO:0002087	regulation of respiratory gaseous exchange by neurological system process
0.70	GO:0021516	dorsal spinal cord development
0.69	GO:0007585	respiratory gaseous exchange
0.67	GO:0008344	adult locomotory behavior
0.62	GO:0048666	neuron development
0.61	GO:0006366	transcription by RNA polymerase II
0.61	GO:0045944	positive regulation of transcription by RNA polymerase II

0.70	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
0.69	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.61	GO:0005667	transcription factor complex

sp|P40429|RL13A_HUMAN
60S ribosomal protein L13a
Search

RPL13A

0.92	Tumor-specific transplantation antigen P198 homolog p23 (Fragment)

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.50	GO:1901194	negative regulation of formation of translation preinitiation complex
0.44	GO:0071346	cellular response to interferon-gamma
0.39	GO:0010469	regulation of receptor activity
0.38	GO:0048246	macrophage chemotaxis
0.38	GO:0060425	lung morphogenesis
0.37	GO:0032496	response to lipopolysaccharide

0.64	GO:0003735	structural constituent of ribosome
0.44	GO:0003729	mRNA binding
0.40	GO:0005125	cytokine activity
0.35	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

0.71	GO:0015934	large ribosomal subunit
0.49	GO:0097452	GAIT complex
0.45	GO:0022626	cytosolic ribosome
0.36	GO:0005925	focal adhesion
0.35	GO:0005730	nucleolus
0.30	GO:0031224	intrinsic component of membrane

0.35

GO:0016620

sp|P40616|ARL1_HUMAN
ADP-ribosylation factor-like protein 1
Search

ARL1

0.89	ADP ribosylation factor like GTPase 1

0.59	GO:0031584	activation of phospholipase D activity
0.55	GO:0034067	protein localization to Golgi apparatus
0.53	GO:0042147	retrograde transport, endosome to Golgi
0.50	GO:0009404	toxin metabolic process
0.48	GO:0007030	Golgi organization
0.37	GO:0048193	Golgi vesicle transport

0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0008047	enzyme activator activity
0.49	GO:0019904	protein domain specific binding
0.47	GO:0003924	GTPase activity
0.38	GO:0046872	metal ion binding

0.53	GO:0005802	trans-Golgi network
0.48	GO:0005829	cytosol
0.37	GO:0000139	Golgi membrane
0.36	GO:0070062	extracellular exosome
0.33	GO:0005643	nuclear pore
0.30	GO:0031224	intrinsic component of membrane

sp|P40617|ARL4A_HUMAN
ADP-ribosylation factor-like protein 4A
Search

ARL4A

0.97	ADP ribosylation factor like GTPase 4A

0.51	GO:0050873	brown fat cell differentiation
0.39	GO:0032456	endocytic recycling
0.33	GO:0016579	protein deubiquitination
0.33	GO:0006511	ubiquitin-dependent protein catabolic process

0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0043014	alpha-tubulin binding
0.33	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.33	GO:0003924	GTPase activity
0.32	GO:0003676	nucleic acid binding

0.48	GO:0005730	nucleolus
0.48	GO:0005829	cytosol
0.47	GO:0005654	nucleoplasm
0.42	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0036459

sp|P40692|MLH1_HUMAN
DNA mismatch repair protein Mlh1
Search

MLH1

0.88	MutL homolog 1, colon cancer, nonpolyposis type 2

0.76	GO:0043060	meiotic metaphase I plate congression
0.75	GO:0006298	mismatch repair
0.72	GO:0016446	somatic hypermutation of immunoglobulin genes
0.72	GO:0051257	meiotic spindle midzone assembly
0.72	GO:0007140	male meiotic nuclear division
0.71	GO:0007129	synapsis
0.71	GO:0048298	positive regulation of isotype switching to IgA isotypes
0.71	GO:0045950	negative regulation of mitotic recombination
0.70	GO:0048304	positive regulation of isotype switching to IgG isotypes
0.70	GO:0016321	female meiosis chromosome segregation

0.75	GO:0030983	mismatched DNA binding
0.73	GO:0032407	MutSalpha complex binding
0.61	GO:0003682	chromatin binding
0.61	GO:0003697	single-stranded DNA binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0016887	ATPase activity

0.82	GO:0032300	mismatch repair complex
0.73	GO:0005715	late recombination nodule
0.73	GO:0005712	chiasma
0.69	GO:0001673	male germ cell nucleus
0.69	GO:0000795	synaptonemal complex
0.58	GO:0005654	nucleoplasm
0.30	GO:0044425	membrane part

0.44

GO:0016887

sp|P40763|STAT3_HUMAN
Signal transducer and activator of transcription 3
Search

STAT3

0.70	Signal transducer and activator of transcription

0.61	GO:0007165	signal transduction
0.58	GO:1904685	positive regulation of metalloendopeptidase activity
0.57	GO:0006351	transcription, DNA-templated
0.57	GO:0006355	regulation of transcription, DNA-templated
0.57	GO:0072540	T-helper 17 cell lineage commitment
0.56	GO:0042755	eating behavior
0.56	GO:0048592	eye morphogenesis
0.56	GO:0060019	radial glial cell differentiation
0.56	GO:1905564	positive regulation of vascular endothelial cell proliferation
0.56	GO:2001223	negative regulation of neuron migration

0.64	GO:0004871	signal transducer activity
0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0001103	RNA polymerase II repressing transcription factor binding
0.55	GO:0003677	DNA binding
0.53	GO:0019903	protein phosphatase binding
0.51	GO:0019901	protein kinase binding
0.51	GO:0003682	chromatin binding
0.50	GO:0001067	regulatory region nucleic acid binding
0.49	GO:0042803	protein homodimerization activity
0.39	GO:0031730	CCR5 chemokine receptor binding

0.61	GO:0005634	nucleus
0.49	GO:0005667	transcription factor complex
0.48	GO:0005737	cytoplasm
0.48	GO:0000785	chromatin
0.46	GO:0070013	intracellular organelle lumen
0.41	GO:0005886	plasma membrane
0.35	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

sp|P40818|UBP8_HUMAN
Ubiquitin carboxyl-terminal hydrolase 8
Search

USP8

0.90	Ubiquitin carboxyl-terminal hydrolase 8

0.76	GO:0016579	protein deubiquitination
0.72	GO:0006511	ubiquitin-dependent protein catabolic process
0.56	GO:0007032	endosome organization
0.56	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.55	GO:0000281	mitotic cytokinesis
0.41	GO:0071549	cellular response to dexamethasone stimulus
0.41	GO:1990090	cellular response to nerve growth factor stimulus
0.36	GO:0007265	Ras protein signal transduction
0.36	GO:0008283	cell proliferation

0.76	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.55	GO:0045296	cadherin binding
0.37	GO:0017124	SH3 domain binding
0.35	GO:0004197	cysteine-type endopeptidase activity
0.32	GO:0008270	zinc ion binding

0.56	GO:0030496	midbody
0.55	GO:0005769	early endosome
0.54	GO:0019898	extrinsic component of membrane
0.51	GO:0005829	cytosol
0.46	GO:0010008	endosome membrane
0.46	GO:0044459	plasma membrane part
0.40	GO:0043197	dendritic spine
0.40	GO:0014069	postsynaptic density
0.36	GO:0001669	acrosomal vesicle
0.34	GO:0005634	nucleus

0.76

GO:0036459

sp|P40855|PEX19_HUMAN
Peroxisomal biogenesis factor 19
Search

PEX19

0.96	Peroxisomal biogenesis factor 19

0.62	GO:1900131	negative regulation of lipid binding
0.59	GO:0045046	protein import into peroxisome membrane
0.58	GO:0072321	chaperone-mediated protein transport
0.55	GO:0016559	peroxisome fission
0.54	GO:0050821	protein stabilization
0.53	GO:0061077	chaperone-mediated protein folding
0.47	GO:0016557	peroxisome membrane biogenesis
0.33	GO:0055085	transmembrane transport

0.62	GO:0033328	peroxisome membrane targeting sequence binding
0.57	GO:0051117	ATPase binding
0.56	GO:0047485	protein N-terminus binding

0.74	GO:0005777	peroxisome
0.55	GO:0031903	microbody membrane
0.49	GO:0005654	nucleoplasm
0.48	GO:0005829	cytosol
0.44	GO:0043234	protein complex
0.39	GO:0031526	brush border membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P40879|S26A3_HUMAN
Chloride anion exchanger
Search

SLC26A3

0.97	Chloride anion exchanger

0.83	GO:0015701	bicarbonate transport
0.75	GO:1902358	sulfate transmembrane transport
0.73	GO:0006821	chloride transport
0.60	GO:0051453	regulation of intracellular pH
0.59	GO:0060081	membrane hyperpolarization
0.59	GO:0045852	pH elevation
0.58	GO:0048240	sperm capacitation
0.58	GO:0071320	cellular response to cAMP
0.53	GO:0019532	oxalate transport
0.42	GO:0032880	regulation of protein localization

0.79	GO:0015301	anion:anion antiporter activity
0.78	GO:0008271	secondary active sulfate transmembrane transporter activity
0.63	GO:0015106	bicarbonate transmembrane transporter activity
0.56	GO:0015108	chloride transmembrane transporter activity
0.53	GO:0019531	oxalate transmembrane transporter activity
0.49	GO:0005253	anion channel activity
0.37	GO:0015296	anion:cation symporter activity
0.37	GO:0015081	sodium ion transmembrane transporter activity
0.35	GO:0005452	inorganic anion exchanger activity
0.35	GO:0003712	transcription cofactor activity

0.64	GO:0005887	integral component of plasma membrane
0.58	GO:0097225	sperm midpiece
0.47	GO:0031526	brush border membrane
0.46	GO:0016324	apical plasma membrane
0.43	GO:0070062	extracellular exosome
0.33	GO:0005783	endoplasmic reticulum

sp|P40925|MDHC_HUMAN
Malate dehydrogenase, cytoplasmic
Search

MDH1

0.46	Malate dehydrogenase

0.78	GO:0006108	malate metabolic process
0.69	GO:0006099	tricarboxylic acid cycle
0.60	GO:0005975	carbohydrate metabolic process
0.48	GO:0006734	NADH metabolic process
0.46	GO:0006107	oxaloacetate metabolic process
0.33	GO:0044283	small molecule biosynthetic process
0.32	GO:1901576	organic substance biosynthetic process

0.78	GO:0030060	L-malate dehydrogenase activity
0.36	GO:0051287	NAD binding
0.36	GO:0047860	diiodophenylpyruvate reductase activity
0.34	GO:0004470	malic enzyme activity
0.33	GO:0005515	protein binding

0.50	GO:0043209	myelin sheath
0.43	GO:0005739	mitochondrion
0.42	GO:0005829	cytosol
0.36	GO:0005615	extracellular space
0.36	GO:1903561	extracellular vesicle
0.30	GO:0016020	membrane

0.78	EC:1.1.1.37	GO:0030060
0.36	KEGG:R03431	GO:0047860

sp|P40926|MDHM_HUMAN
Malate dehydrogenase, mitochondrial
Search

MDH2

0.46	Malate dehydrogenase, mitochondrial

0.78	GO:0006108	malate metabolic process
0.70	GO:0006099	tricarboxylic acid cycle
0.60	GO:0005975	carbohydrate metabolic process
0.52	GO:0006475	internal protein amino acid acetylation
0.39	GO:0006734	NADH metabolic process
0.38	GO:0006107	oxaloacetate metabolic process
0.33	GO:0044283	small molecule biosynthetic process
0.32	GO:1901576	organic substance biosynthetic process

0.79	GO:0030060	L-malate dehydrogenase activity
0.40	GO:0046554	malate dehydrogenase (NADP+) activity
0.40	GO:0042803	protein homodimerization activity
0.39	GO:0043621	protein self-association
0.34	GO:0051087	chaperone binding
0.34	GO:0003723	RNA binding

0.52	GO:0043209	myelin sheath
0.45	GO:0044429	mitochondrial part
0.44	GO:0019866	organelle inner membrane
0.39	GO:0031974	membrane-enclosed lumen
0.36	GO:0070062	extracellular exosome
0.34	GO:0005634	nucleus

0.79	EC:1.1.1.37	GO:0030060
0.40	KEGG:R00343	GO:0046554

sp|P40933|IL15_HUMAN
Interleukin-15
Search

IL15

0.95	Interleukin

0.75	GO:0010469	regulation of receptor activity
0.74	GO:0006955	immune response
0.66	GO:0035723	interleukin-15-mediated signaling pathway
0.66	GO:0045062	extrathymic T cell selection
0.66	GO:1904098	regulation of protein O-linked glycosylation
0.65	GO:0007260	tyrosine phosphorylation of STAT protein
0.64	GO:0032740	positive regulation of interleukin-17 production
0.64	GO:0032819	positive regulation of natural killer cell proliferation
0.64	GO:0060050	positive regulation of protein glycosylation
0.64	GO:0001866	NK T cell proliferation

0.80	GO:0005125	cytokine activity
0.79	GO:0005126	cytokine receptor binding

0.73	GO:0005615	extracellular space
0.59	GO:0016607	nuclear speck
0.52	GO:0005829	cytosol
0.40	GO:0009986	cell surface
0.36	GO:0005768	endosome
0.35	GO:0005794	Golgi apparatus
0.35	GO:0005887	integral component of plasma membrane

sp|P40937|RFC5_HUMAN
Replication factor C subunit 5
Search

RFC5

0.85	Replication factor C subunit 5

0.66	GO:0006260	DNA replication
0.57	GO:1900264	positive regulation of DNA-directed DNA polymerase activity
0.45	GO:0060041	retina development in camera-type eye
0.42	GO:0006281	DNA repair
0.35	GO:0042769	DNA damage response, detection of DNA damage
0.35	GO:1901796	regulation of signal transduction by p53 class mediator
0.34	GO:0000723	telomere maintenance
0.34	GO:0071897	DNA biosynthetic process
0.34	GO:0022402	cell cycle process
0.33	GO:0019725	cellular homeostasis

0.56	GO:0003689	DNA clamp loader activity
0.54	GO:0043142	single-stranded DNA-dependent ATPase activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0019899	enzyme binding
0.33	GO:0003887	DNA-directed DNA polymerase activity

0.56	GO:0005663	DNA replication factor C complex
0.54	GO:0031390	Ctf18 RFC-like complex
0.41	GO:0005634	nucleus
0.33	GO:0031974	membrane-enclosed lumen
0.30	GO:0016020	membrane

0.33

GO:0003887

sp|P40938|RFC3_HUMAN
Replication factor C subunit 3
Search

RFC3

0.87	Replication factor C subunit 3

0.63	GO:0006260	DNA replication
0.57	GO:1900264	positive regulation of DNA-directed DNA polymerase activity
0.54	GO:0046683	response to organophosphorus
0.41	GO:0006281	DNA repair
0.35	GO:0042769	DNA damage response, detection of DNA damage
0.35	GO:1901796	regulation of signal transduction by p53 class mediator
0.35	GO:0022616	DNA strand elongation
0.34	GO:0000723	telomere maintenance
0.34	GO:0071897	DNA biosynthetic process
0.34	GO:0022402	cell cycle process

0.56	GO:0003689	DNA clamp loader activity
0.54	GO:0043142	single-stranded DNA-dependent ATPase activity
0.33	GO:0005515	protein binding
0.33	GO:0003887	DNA-directed DNA polymerase activity

0.55	GO:0005663	DNA replication factor C complex
0.54	GO:0031390	Ctf18 RFC-like complex
0.40	GO:0005634	nucleus
0.33	GO:0043233	organelle lumen

0.33

GO:0003887

sp|P40939|ECHA_HUMAN
Trifunctional enzyme subunit alpha, mitochondrial
Search

HADHA

0.88	Hydroxyacyl-coenzyme A dehydrogenase/3-ketoacyl-coenzyme A thiolase/enoyl-coenzyme A hydratase alpha subunit

0.77	GO:0006635	fatty acid beta-oxidation
0.42	GO:0032868	response to insulin

0.79	GO:0004300	enoyl-CoA hydratase activity
0.76	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity

0.86	GO:0016507	mitochondrial fatty acid beta-oxidation multienzyme complex
0.48	GO:0042645	mitochondrial nucleoid
0.38	GO:0019866	organelle inner membrane
0.38	GO:0031966	mitochondrial membrane

0.79

EC:4.2.1.17

GO:0004300

sp|P40967|PMEL_HUMAN
Melanocyte protein PMEL
Search

PMEL

0.40	Melanocyte protein PMEL

0.67	GO:0032438	melanosome organization
0.51	GO:0048066	developmental pigmentation
0.38	GO:0042438	melanin biosynthetic process
0.37	GO:0048023	positive regulation of melanin biosynthetic process
0.36	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
0.34	GO:0016310	phosphorylation
0.33	GO:0045944	positive regulation of transcription by RNA polymerase II
0.32	GO:0006351	transcription, DNA-templated

0.55	GO:0042802	identical protein binding
0.36	GO:0004143	diacylglycerol kinase activity
0.36	GO:0003951	NAD+ kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.32	GO:0046983	protein dimerization activity

0.64	GO:0032585	multivesicular body membrane
0.63	GO:0042470	melanosome
0.54	GO:0005789	endoplasmic reticulum membrane
0.54	GO:0005794	Golgi apparatus
0.43	GO:0005887	integral component of plasma membrane
0.34	GO:0005576	extracellular region
0.32	GO:0060205	cytoplasmic vesicle lumen
0.32	GO:0005634	nucleus

0.36	EC:2.7.1.107	GO:0004143
0.36	KEGG:R00104	GO:0003951

sp|P41002|CCNF_HUMAN
Cyclin-F
Search

CCNF

0.97

Cyclin-F

0.71	GO:0051726	regulation of cell cycle
0.60	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
0.59	GO:0000320	re-entry into mitotic cell cycle
0.58	GO:0070507	regulation of microtubule cytoskeleton organization
0.57	GO:0051494	negative regulation of cytoskeleton organization
0.56	GO:0001890	placenta development
0.53	GO:0016567	protein ubiquitination
0.39	GO:0051301	cell division
0.36	GO:0043687	post-translational protein modification
0.35	GO:0055085	transmembrane transport

0.38	GO:0004842	ubiquitin-protein transferase activity
0.37	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.36	GO:0030554	adenyl nucleotide binding
0.36	GO:0097367	carbohydrate derivative binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0008144	drug binding
0.35	GO:0005515	protein binding
0.33	GO:0017127	cholesterol transporter activity
0.33	GO:0005543	phospholipid binding
0.32	GO:1901681	sulfur compound binding

0.60	GO:0005634	nucleus
0.59	GO:0019005	SCF ubiquitin ligase complex
0.59	GO:0005814	centriole
0.55	GO:0005813	centrosome
0.54	GO:0030054	cell junction
0.35	GO:0005829	cytosol
0.34	GO:0034359	mature chylomicron
0.33	GO:0034363	intermediate-density lipoprotein particle
0.33	GO:0034362	low-density lipoprotein particle
0.33	GO:0031983	vesicle lumen

0.38

KEGG:R03876

GO:0004842

sp|P41091|IF2G_HUMAN
Eukaryotic translation initiation factor 2 subunit 3
Search

EIF2S3

0.78	Eukaryotic translation initiation factor 2 subunit gamma X

0.62	GO:0006413	translational initiation
0.32	GO:0055085	transmembrane transport

0.67	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.62	GO:0003743	translation initiation factor activity
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0045296	cadherin binding

0.44	GO:0005850	eukaryotic translation initiation factor 2 complex
0.36	GO:0070062	extracellular exosome
0.34	GO:0005634	nucleus
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|P41134|ID1_HUMAN
DNA-binding protein inhibitor ID-1
Search

ID1

0.97	DNA-binding protein inhibitor

0.70	GO:0045892	negative regulation of transcription, DNA-templated
0.61	GO:0090074	negative regulation of protein homodimerization activity
0.61	GO:0060426	lung vasculature development
0.61	GO:0001886	endothelial cell morphogenesis
0.59	GO:0045667	regulation of osteoblast differentiation
0.59	GO:0043392	negative regulation of DNA binding
0.59	GO:0060425	lung morphogenesis
0.59	GO:0032963	collagen metabolic process
0.58	GO:0031648	protein destabilization
0.58	GO:0030279	negative regulation of ossification

0.67	GO:0046983	protein dimerization activity
0.58	GO:0043621	protein self-association
0.46	GO:0003700	DNA binding transcription factor activity
0.45	GO:0003677	DNA binding
0.42	GO:0008134	transcription factor binding
0.40	GO:0047485	protein N-terminus binding
0.40	GO:0070628	proteasome binding
0.39	GO:0008022	protein C-terminus binding
0.38	GO:0042802	identical protein binding
0.34	GO:1901707	leptomycin B binding

0.60	GO:0005634	nucleus
0.51	GO:0005794	Golgi apparatus
0.49	GO:0070013	intracellular organelle lumen
0.44	GO:0044446	intracellular organelle part
0.37	GO:0015630	microtubule cytoskeleton

sp|P41143|OPRD_HUMAN
Delta-type opioid receptor
Search

OPRD1

0.97	Delta-type opioid receptor

0.86	GO:0038003	opioid receptor signaling pathway
0.63	GO:0007218	neuropeptide signaling pathway
0.58	GO:0032460	negative regulation of protein oligomerization
0.58	GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
0.56	GO:0000060	protein import into nucleus, translocation
0.56	GO:0030534	adult behavior
0.56	GO:0051881	regulation of mitochondrial membrane potential
0.55	GO:0033138	positive regulation of peptidyl-serine phosphorylation
0.55	GO:0071456	cellular response to hypoxia
0.55	GO:0007626	locomotory behavior

0.86	GO:0004985	opioid receptor activity
0.54	GO:0004977	melanocortin receptor activity
0.53	GO:0008188	neuropeptide receptor activity
0.53	GO:0099528	G-protein coupled neurotransmitter receptor activity
0.52	GO:0042923	neuropeptide binding
0.45	GO:0001965	G-protein alpha-subunit binding
0.41	GO:0031681	G-protein beta-subunit binding
0.36	GO:0005245	voltage-gated calcium channel activity
0.36	GO:0031005	filamin binding
0.35	GO:0008022	protein C-terminus binding

0.49	GO:0031226	intrinsic component of plasma membrane
0.48	GO:0043005	neuron projection
0.42	GO:0045203	integral component of cell outer membrane
0.41	GO:0031256	leading edge membrane
0.41	GO:0036477	somatodendritic compartment
0.40	GO:0031253	cell projection membrane
0.40	GO:0098857	membrane microdomain
0.40	GO:0098794	postsynapse
0.39	GO:0031982	vesicle
0.39	GO:0097060	synaptic membrane

sp|P41145|OPRK_HUMAN
Kappa-type opioid receptor
Search

OPRK1

0.97	Kappa-type opioid receptor

0.85	GO:0038003	opioid receptor signaling pathway
0.57	GO:0046877	regulation of saliva secretion
0.56	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.56	GO:0019233	sensory perception of pain
0.52	GO:0051607	defense response to virus
0.52	GO:0007626	locomotory behavior
0.51	GO:0006955	immune response
0.49	GO:0007218	neuropeptide signaling pathway
0.45	GO:0007268	chemical synaptic transmission
0.42	GO:0043278	response to morphine

0.85	GO:0004985	opioid receptor activity
0.49	GO:0042923	neuropeptide binding
0.41	GO:0004977	melanocortin receptor activity
0.41	GO:0008188	neuropeptide receptor activity
0.41	GO:0099528	G-protein coupled neurotransmitter receptor activity
0.35	GO:0005515	protein binding
0.34	GO:0005245	voltage-gated calcium channel activity

0.49	GO:0005887	integral component of plasma membrane
0.48	GO:0005829	cytosol
0.46	GO:0043005	neuron projection
0.45	GO:0005634	nucleus
0.40	GO:0043204	perikaryon
0.39	GO:0120038	plasma membrane bounded cell projection part
0.39	GO:0098793	presynapse
0.33	GO:0005768	endosome

sp|P41146|OPRX_HUMAN
Nociceptin receptor
Search

OPRL1

0.97	Nociceptin receptor

0.86	GO:0038003	opioid receptor signaling pathway
0.64	GO:0019233	sensory perception of pain
0.62	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.59	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.49	GO:0007218	neuropeptide signaling pathway
0.48	GO:0007268	chemical synaptic transmission
0.44	GO:0060454	positive regulation of gastric acid secretion
0.43	GO:1904058	positive regulation of sensory perception of pain
0.43	GO:0044849	estrous cycle
0.43	GO:0106072	negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway

0.87	GO:0001626	nociceptin receptor activity
0.52	GO:0042923	neuropeptide binding
0.41	GO:0008022	protein C-terminus binding

0.52	GO:0005887	integral component of plasma membrane
0.48	GO:0043005	neuron projection
0.41	GO:0031410	cytoplasmic vesicle

sp|P41159|LEP_HUMAN
Leptin
Search

LEP

0.97

Leptin

0.75	GO:0010469	regulation of receptor activity
0.65	GO:1990051	activation of protein kinase C activity
0.65	GO:0032615	interleukin-12 production
0.64	GO:0072604	interleukin-6 secretion
0.64	GO:0032310	prostaglandin secretion
0.64	GO:0072606	interleukin-8 secretion
0.63	GO:0032817	regulation of natural killer cell proliferation
0.63	GO:0032868	response to insulin
0.63	GO:0090335	regulation of brown fat cell differentiation
0.62	GO:0032099	negative regulation of appetite

0.79	GO:0005179	hormone activity
0.49	GO:0051428	peptide hormone receptor binding
0.34	GO:0005125	cytokine activity

0.66	GO:0005576	extracellular region
0.39	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|P41161|ETV5_HUMAN
ETS translocation variant 5
Search

ETV5

0.90	ETS translocation variant 5

0.66	GO:0006366	transcription by RNA polymerase II
0.65	GO:0048934	peripheral nervous system neuron differentiation
0.62	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis
0.62	GO:0071340	skeletal muscle acetylcholine-gated channel clustering
0.59	GO:0007274	neuromuscular synaptic transmission
0.58	GO:0048666	neuron development
0.58	GO:0007610	behavior
0.58	GO:0050807	regulation of synapse organization
0.57	GO:0045944	positive regulation of transcription by RNA polymerase II
0.54	GO:0034599	cellular response to oxidative stress

0.63	GO:0043565	sequence-specific DNA binding
0.61	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.59	GO:0001012	RNA polymerase II regulatory region DNA binding
0.55	GO:0003690	double-stranded DNA binding
0.44	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.34	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.50	GO:0031974	membrane-enclosed lumen
0.45	GO:0044446	intracellular organelle part
0.43	GO:0005886	plasma membrane

sp|P41162|ETV3_HUMAN
ETS translocation variant 3
Search

ETV3

0.96	ETS domain-containing transcription factor ERF

0.76	GO:0000122	negative regulation of transcription by RNA polymerase II
0.59	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus
0.53	GO:0008285	negative regulation of cell proliferation
0.47	GO:0030154	cell differentiation
0.38	GO:0006351	transcription, DNA-templated
0.33	GO:0006468	protein phosphorylation

0.80	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.63	GO:0043565	sequence-specific DNA binding
0.59	GO:0017151	DEAD/H-box RNA helicase binding
0.53	GO:0001012	RNA polymerase II regulatory region DNA binding
0.50	GO:0003690	double-stranded DNA binding
0.40	GO:0003714	transcription corepressor activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding

0.60	GO:0005634	nucleus
0.54	GO:0017053	transcriptional repressor complex
0.50	GO:0000785	chromatin
0.48	GO:0031974	membrane-enclosed lumen
0.30	GO:0031224	intrinsic component of membrane

sp|P41180|CASR_HUMAN
Extracellular calcium-sensing receptor
Search

CASR

0.93	Extracellular calcium-sensing receptor

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.64	GO:0005513	detection of calcium ion
0.60	GO:0055074	calcium ion homeostasis
0.59	GO:0070509	calcium ion import
0.58	GO:0072503	cellular divalent inorganic cation homeostasis
0.57	GO:0051924	regulation of calcium ion transport
0.57	GO:0032781	positive regulation of ATPase activity
0.55	GO:0006875	cellular metal ion homeostasis
0.52	GO:0010628	positive regulation of gene expression
0.44	GO:0042311	vasodilation

0.71	GO:0004930	G-protein coupled receptor activity
0.55	GO:0016597	amino acid binding
0.55	GO:0042803	protein homodimerization activity
0.52	GO:0005509	calcium ion binding
0.42	GO:0044325	ion channel binding
0.42	GO:0005178	integrin binding
0.41	GO:0019808	polyamine binding
0.40	GO:0019901	protein kinase binding
0.38	GO:0000287	magnesium ion binding
0.36	GO:0004435	phosphatidylinositol phospholipase C activity

0.53	GO:0005886	plasma membrane
0.43	GO:0043679	axon terminus
0.41	GO:0043025	neuronal cell body
0.41	GO:0045177	apical part of cell
0.41	GO:0030424	axon
0.40	GO:0009986	cell surface
0.37	GO:0005634	nucleus
0.34	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.36	EC:3.1.4.11	GO:0004435
0.36	KEGG:R03435	GO:0004435

sp|P41181|AQP2_HUMAN
Aquaporin-2
Search

AQP2

0.95	Aquaporin-2

0.60	GO:0071288	cellular response to mercury ion
0.58	GO:0071280	cellular response to copper ion
0.58	GO:0015793	glycerol transport
0.58	GO:0072205	metanephric collecting duct development
0.58	GO:0003097	renal water transport
0.57	GO:0042631	cellular response to water deprivation
0.55	GO:0055085	transmembrane transport
0.38	GO:0006811	ion transport
0.35	GO:0007588	excretion
0.35	GO:0030157	pancreatic juice secretion

0.69	GO:0022803	passive transmembrane transporter activity
0.59	GO:0015168	glycerol transmembrane transporter activity
0.57	GO:0005372	water transmembrane transporter activity
0.35	GO:0005515	protein binding

0.57	GO:0016324	apical plasma membrane
0.54	GO:0055037	recycling endosome
0.54	GO:0070062	extracellular exosome
0.45	GO:0016323	basolateral plasma membrane
0.42	GO:0030659	cytoplasmic vesicle membrane
0.41	GO:0005794	Golgi apparatus
0.40	GO:0005887	integral component of plasma membrane
0.36	GO:0030133	transport vesicle
0.36	GO:0046930	pore complex
0.36	GO:0031303	integral component of endosome membrane

sp|P41182|BCL6_HUMAN
B-cell lymphoma 6 protein
Search

BCL6

0.97	B-cell lymphoma 6 protein homolog

0.61	GO:0042092	type 2 immune response
0.61	GO:0032764	negative regulation of mast cell cytokine production
0.60	GO:0043380	regulation of memory T cell differentiation
0.60	GO:0048294	negative regulation of isotype switching to IgE isotypes
0.60	GO:0045591	positive regulation of regulatory T cell differentiation
0.59	GO:0045629	negative regulation of T-helper 2 cell differentiation
0.59	GO:0002467	germinal center formation
0.58	GO:0000060	protein import into nucleus, translocation
0.58	GO:2000773	negative regulation of cellular senescence
0.58	GO:0031065	positive regulation of histone deacetylation

0.58	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding
0.55	GO:0031490	chromatin DNA binding
0.55	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.52	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.51	GO:0042802	identical protein binding
0.34	GO:0005179	hormone activity
0.34	GO:0046872	metal ion binding

0.52	GO:0005657	replication fork
0.50	GO:0005794	Golgi apparatus
0.49	GO:0005654	nucleoplasm
0.33	GO:0005576	extracellular region
0.30	GO:0016020	membrane

sp|P41208|CETN2_HUMAN
Centrin-2
Search

CETN2

0.79	Centrin, EF-hand protein, 2

0.49	GO:0007099	centriole replication
0.46	GO:0032465	regulation of cytokinesis
0.45	GO:0007283	spermatogenesis
0.44	GO:0006289	nucleotide-excision repair
0.38	GO:0034605	cellular response to heat
0.36	GO:0051301	cell division
0.35	GO:0060271	cilium assembly
0.35	GO:0051640	organelle localization
0.35	GO:0000086	G2/M transition of mitotic cell cycle
0.34	GO:0010389	regulation of G2/M transition of mitotic cell cycle

0.70	GO:0005509	calcium ion binding
0.53	GO:0032795	heterotrimeric G-protein binding
0.48	GO:0031683	G-protein beta/gamma-subunit complex binding
0.44	GO:0008017	microtubule binding

0.53	GO:0005814	centriole
0.51	GO:0071942	XPC complex
0.50	GO:0005813	centrosome
0.48	GO:0032391	photoreceptor connecting cilium
0.47	GO:0036064	ciliary basal body
0.42	GO:0000922	spindle pole
0.34	GO:0030008	TRAPP complex
0.33	GO:0005654	nucleoplasm
0.33	GO:0005829	cytosol

sp|P41212|ETV6_HUMAN
Transcription factor ETV6
Search

ETV6

0.90	Transcription factor ETV6

0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.46	GO:0097152	mesenchymal cell apoptotic process
0.45	GO:0071425	hematopoietic stem cell proliferation
0.45	GO:0007296	vitellogenesis
0.41	GO:0030154	cell differentiation
0.41	GO:0006366	transcription by RNA polymerase II
0.41	GO:0007399	nervous system development
0.40	GO:0051254	positive regulation of RNA metabolic process

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.41	GO:0001012	RNA polymerase II regulatory region DNA binding
0.40	GO:0003690	double-stranded DNA binding
0.40	GO:0019904	protein domain specific binding

0.61	GO:0005634	nucleus
0.38	GO:0005829	cytosol
0.38	GO:0031974	membrane-enclosed lumen
0.36	GO:0043232	intracellular non-membrane-bounded organelle
0.36	GO:0044446	intracellular organelle part

sp|P41214|EIF2D_HUMAN
Eukaryotic translation initiation factor 2D
Search

EIF2D

0.93	Eukaryotic translation initiation factor 2D

0.70	GO:0006413	translational initiation
0.61	GO:0075522	IRES-dependent viral translational initiation
0.59	GO:0032790	ribosome disassembly
0.56	GO:0002181	cytoplasmic translation
0.54	GO:0022618	ribonucleoprotein complex assembly
0.34	GO:0006886	intracellular protein transport

0.70	GO:0003743	translation initiation factor activity
0.34	GO:0004872	receptor activity

0.57	GO:0022627	cytosolic small ribosomal subunit
0.54	GO:0016604	nuclear body
0.30	GO:0031224	intrinsic component of membrane

sp|P41217|OX2G_HUMAN
OX-2 membrane glycoprotein
Search

CD200

0.91	OX-2 membrane glycoprotein isoform a

0.86	GO:0043031	negative regulation of macrophage activation
0.72	GO:0050776	regulation of immune response
0.51	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
0.48	GO:0008037	cell recognition
0.48	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

0.48	GO:0050839	cell adhesion molecule binding
0.47	GO:0042803	protein homodimerization activity
0.46	GO:0005102	receptor binding
0.43	GO:0004872	receptor activity

0.50	GO:0005913	cell-cell adherens junction
0.44	GO:0005887	integral component of plasma membrane

sp|P41218|MNDA_HUMAN
Myeloid cell nuclear differentiation antigen
Search

0.97	Myeloid cell nuclear differentiation antigen

0.73	GO:0030889	negative regulation of B cell proliferation
0.71	GO:0050853	B cell receptor signaling pathway
0.65	GO:0043065	positive regulation of apoptotic process
0.59	GO:0035457	cellular response to interferon-alpha
0.58	GO:1902164	positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
0.55	GO:0006974	cellular response to DNA damage stimulus
0.55	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.54	GO:0031648	protein destabilization
0.54	GO:0043388	positive regulation of DNA binding
0.53	GO:1900182	positive regulation of protein localization to nucleus

0.51	GO:0031625	ubiquitin protein ligase binding
0.47	GO:0003690	double-stranded DNA binding
0.46	GO:0042802	identical protein binding
0.45	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.45	GO:0001047	core promoter binding
0.43	GO:0001012	RNA polymerase II regulatory region DNA binding
0.42	GO:0008134	transcription factor binding
0.40	GO:0043565	sequence-specific DNA binding
0.39	GO:0003712	transcription cofactor activity

0.65	GO:0005730	nucleolus
0.64	GO:0005654	nucleoplasm
0.45	GO:0097169	AIM2 inflammasome complex
0.45	GO:1904813	ficolin-1-rich granule lumen
0.45	GO:0035578	azurophil granule lumen
0.44	GO:0070062	extracellular exosome
0.43	GO:0034399	nuclear periphery
0.42	GO:0042405	nuclear inclusion body
0.38	GO:0005739	mitochondrion

sp|P41219|PERI_HUMAN
Peripherin
Search

PRPH

0.82	Muscle-specific intermediate filament desmin (Predicted)

0.49	GO:0045104	intermediate filament cytoskeleton organization
0.46	GO:0009888	tissue development
0.46	GO:0060020	Bergmann glial cell differentiation
0.45	GO:0010714	positive regulation of collagen metabolic process
0.45	GO:0014002	astrocyte development
0.45	GO:0032965	regulation of collagen biosynthetic process
0.45	GO:0097435	supramolecular fiber organization
0.44	GO:0060395	SMAD protein signal transduction
0.44	GO:0002088	lens development in camera-type eye
0.44	GO:0071346	cellular response to interferon-gamma

0.62	GO:0005198	structural molecule activity
0.46	GO:1990254	keratin filament binding
0.45	GO:0097110	scaffold protein binding
0.44	GO:0008022	protein C-terminus binding
0.43	GO:0042802	identical protein binding
0.42	GO:0019904	protein domain specific binding
0.42	GO:0003725	double-stranded RNA binding
0.37	GO:0008092	cytoskeletal protein binding
0.34	GO:0046982	protein heterodimerization activity

0.79	GO:0005882	intermediate filament
0.44	GO:0045335	phagocytic vesicle
0.43	GO:0043005	neuron projection
0.43	GO:0005844	polysome
0.43	GO:0031252	cell leading edge
0.43	GO:0030018	Z disc
0.42	GO:0005777	peroxisome
0.41	GO:0005916	fascia adherens
0.41	GO:0042383	sarcolemma
0.40	GO:0097512	cardiac myofibril

sp|P41220|RGS2_HUMAN
Regulator of G-protein signaling 2
Search

RGS2

0.97	Regulator of G-protein signaling protein 2

0.80	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
0.74	GO:0043547	positive regulation of GTPase activity
0.63	GO:0010519	negative regulation of phospholipase activity
0.62	GO:0071877	regulation of adrenergic receptor signaling pathway
0.62	GO:0060087	relaxation of vascular smooth muscle
0.62	GO:0060452	positive regulation of cardiac muscle contraction
0.62	GO:0055119	relaxation of cardiac muscle
0.61	GO:0010614	negative regulation of cardiac muscle hypertrophy
0.61	GO:0043951	negative regulation of cAMP-mediated signaling
0.59	GO:0050873	brown fat cell differentiation

0.74	GO:0005096	GTPase activator activity
0.61	GO:0001965	G-protein alpha-subunit binding
0.41	GO:0048487	beta-tubulin binding
0.35	GO:0005516	calmodulin binding

0.54	GO:0009898	cytoplasmic side of plasma membrane
0.51	GO:0005829	cytosol
0.47	GO:0005634	nucleus
0.39	GO:0043005	neuron projection
0.38	GO:0043233	organelle lumen
0.36	GO:0043232	intracellular non-membrane-bounded organelle
0.36	GO:0044446	intracellular organelle part
0.33	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

sp|P41221|WNT5A_HUMAN
Protein Wnt-5a
Search

sp|P41222|PTGDS_HUMAN
Prostaglandin-H2 D-isomerase
Search

PTGDS

0.83	Prostaglandin D synthase

0.72	GO:0046457	prostanoid biosynthetic process
0.71	GO:0006693	prostaglandin metabolic process
0.68	GO:0045187	regulation of circadian sleep/wake cycle, sleep
0.65	GO:2000255	negative regulation of male germ cell proliferation
0.40	GO:0051384	response to glucocorticoid
0.39	GO:0019369	arachidonic acid metabolic process
0.38	GO:0044793	negative regulation by host of viral process
0.38	GO:0045071	negative regulation of viral genome replication
0.36	GO:0006303	double-strand break repair via nonhomologous end joining

0.77	GO:0004667	prostaglandin-D synthase activity
0.66	GO:0005501	retinoid binding
0.51	GO:0036094	small molecule binding
0.37	GO:0005515	protein binding
0.35	GO:0043168	anion binding

0.58	GO:0005791	rough endoplasmic reticulum
0.57	GO:0005576	extracellular region
0.54	GO:0031965	nuclear membrane
0.53	GO:0048471	perinuclear region of cytoplasm
0.50	GO:0005794	Golgi apparatus
0.38	GO:0031982	vesicle
0.36	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

0.77	EC:5.3.99.2	GO:0004667
0.77	KEGG:R02266	GO:0004667

sp|P41223|BUD31_HUMAN
Protein BUD31 homolog
Search

BUD31

0.90	Putative g10 protein/ nuclear transcription regulator

0.57	GO:2000825	positive regulation of androgen receptor activity
0.51	GO:0000398	mRNA splicing, via spliceosome
0.33	GO:0007275	multicellular organism development

0.53	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
0.53	GO:0035257	nuclear hormone receptor binding
0.33	GO:0003700	DNA binding transcription factor activity

0.61	GO:0005634	nucleus
0.48	GO:0000785	chromatin
0.46	GO:0031974	membrane-enclosed lumen
0.44	GO:0030529	intracellular ribonucleoprotein complex
0.43	GO:1902494	catalytic complex
0.30	GO:0031224	intrinsic component of membrane

sp|P41225|SOX3_HUMAN
Transcription factor SOX-3
Search

SOX3

0.91	Transcription factor SOX-3

0.56	GO:0007530	sex determination
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.48	GO:0007399	nervous system development
0.43	GO:0007423	sensory organ development
0.42	GO:0060324	face development
0.41	GO:0035270	endocrine system development
0.41	GO:0030154	cell differentiation
0.41	GO:0051961	negative regulation of nervous system development

0.54	GO:0003677	DNA binding
0.42	GO:0001106	RNA polymerase II transcription corepressor activity
0.40	GO:0001067	regulatory region nucleic acid binding
0.36	GO:0003700	DNA binding transcription factor activity
0.35	GO:0008013	beta-catenin binding
0.33	GO:0035198	miRNA binding

0.61	GO:0005634	nucleus
0.48	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.32	GO:0005737	cytoplasm

sp|P41226|UBA7_HUMAN
Ubiquitin-like modifier-activating enzyme 7
Search

UBA7

0.80	Ubiquitin like modifier activating enzyme 7

0.60	GO:0036211	protein modification process
0.55	GO:0044267	cellular protein metabolic process
0.53	GO:0043632	modification-dependent macromolecule catabolic process
0.52	GO:0030163	protein catabolic process
0.47	GO:0006508	proteolysis
0.45	GO:0006974	cellular response to DNA damage stimulus
0.37	GO:0007409	axonogenesis
0.36	GO:0032480	negative regulation of type I interferon production
0.36	GO:0007283	spermatogenesis
0.34	GO:0071897	DNA biosynthetic process

0.76	GO:0008641	ubiquitin-like modifier activating enzyme activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0004842	ubiquitin-protein transferase activity
0.35	GO:0016881	acid-amino acid ligase activity
0.34	GO:0005515	protein binding
0.33	GO:0051539	4 iron, 4 sulfur cluster binding
0.32	GO:0003723	RNA binding
0.32	GO:0046872	metal ion binding

0.45	GO:0030057	desmosome
0.44	GO:0030867	rough endoplasmic reticulum membrane
0.44	GO:0000792	heterochromatin
0.44	GO:0005765	lysosomal membrane
0.43	GO:0010008	endosome membrane
0.42	GO:0005654	nucleoplasm
0.41	GO:0005829	cytosol
0.38	GO:0005739	mitochondrion
0.34	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.35	EC:6.3.2	GO:0016881
0.38	KEGG:R03876	GO:0004842

sp|P41227|NAA10_HUMAN
N-alpha-acetyltransferase 10
Search

NAA10

0.96	N-terminal acetyltransferase complex ARD1 subunit like protein A

0.57	GO:2000719	negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric
0.57	GO:0006474	N-terminal protein amino acid acetylation
0.54	GO:0030920	peptidyl-serine acetylation
0.51	GO:0018200	peptidyl-glutamic acid modification
0.50	GO:0018209	peptidyl-serine modification
0.49	GO:0006475	internal protein amino acid acetylation
0.35	GO:0043547	positive regulation of GTPase activity
0.34	GO:0006323	DNA packaging
0.34	GO:0000398	mRNA splicing, via spliceosome
0.33	GO:0007165	signal transduction

0.68	GO:0008080	N-acetyltransferase activity
0.48	GO:0043022	ribosome binding
0.35	GO:0005096	GTPase activator activity
0.35	GO:0005515	protein binding
0.34	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.33	GO:0016301	kinase activity
0.33	GO:0140096	catalytic activity, acting on a protein
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0003677	DNA binding
0.32	GO:0008144	drug binding

0.62	GO:0031415	NatA complex
0.49	GO:0005829	cytosol
0.48	GO:0005730	nucleolus
0.42	GO:1990904	ribonucleoprotein complex
0.37	GO:0071339	MLL1 complex
0.37	GO:0048188	Set1C/COMPASS complex
0.30	GO:0016020	membrane

0.68

GO:0008080

sp|P41229|KDM5C_HUMAN
Lysine-specific demethylase 5C
Search

KDM5C

0.96	Jumonji AT rich interactive domain 1D

0.58	GO:0034720	histone H3-K4 demethylation
0.53	GO:0032259	methylation
0.48	GO:0045892	negative regulation of transcription, DNA-templated
0.40	GO:0060765	regulation of androgen receptor signaling pathway
0.40	GO:0002457	T cell antigen processing and presentation
0.38	GO:0043524	negative regulation of neuron apoptotic process
0.38	GO:0048511	rhythmic process
0.38	GO:0009636	response to toxic substance
0.36	GO:0055114	oxidation-reduction process
0.36	GO:0006351	transcription, DNA-templated

0.58	GO:0032453	histone demethylase activity (H3-K4 specific)
0.54	GO:0003677	DNA binding
0.54	GO:0046872	metal ion binding
0.53	GO:0008168	methyltransferase activity
0.40	GO:0050681	androgen receptor binding
0.39	GO:0051213	dioxygenase activity
0.37	GO:0001085	RNA polymerase II transcription factor binding
0.36	GO:0005086	ARF guanyl-nucleotide exchange factor activity
0.35	GO:0042802	identical protein binding

0.61	GO:0005634	nucleus
0.47	GO:0031974	membrane-enclosed lumen
0.46	GO:0005829	cytosol
0.42	GO:0044446	intracellular organelle part
0.35	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane

0.53

GO:0008168

sp|P41231|P2RY2_HUMAN
P2Y purinoceptor 2
Search

P2RY2

0.97	Purinergic receptor P2Y, G-protein coupled, 2

0.85	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
0.79	GO:0070257	positive regulation of mucus secretion
0.75	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
0.73	GO:0097746	regulation of blood vessel diameter
0.65	GO:0030321	transepithelial chloride transport
0.50	GO:0071380	cellular response to prostaglandin E stimulus
0.37	GO:0006873	cellular ion homeostasis
0.36	GO:0060406	positive regulation of penile erection
0.36	GO:0032308	positive regulation of prostaglandin secretion
0.36	GO:0071415	cellular response to purine-containing compound

0.85	GO:0045028	G-protein coupled purinergic nucleotide receptor activity
0.53	GO:0045030	UTP-activated nucleotide receptor activity
0.37	GO:0031686	A1 adenosine receptor binding
0.34	GO:0019103	pyrimidine nucleotide binding
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.39	GO:0016323	basolateral plasma membrane
0.39	GO:0016324	apical plasma membrane
0.35	GO:0005769	early endosome
0.35	GO:0005764	lysosome
0.35	GO:0005887	integral component of plasma membrane
0.33	GO:0005739	mitochondrion

sp|P41235|HNF4A_HUMAN
Hepatocyte nuclear factor 4-alpha
Search

HNF4A

0.94	Hepatocyte nuclear factor 4-alpha

0.79	GO:0043401	steroid hormone mediated signaling pathway
0.75	GO:0030522	intracellular receptor signaling pathway
0.59	GO:2000189	positive regulation of cholesterol homeostasis
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:0055091	phospholipid homeostasis
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:0023019	signal transduction involved in regulation of gene expression
0.56	GO:0070328	triglyceride homeostasis
0.56	GO:0010470	regulation of gastrulation

0.80	GO:0003707	steroid hormone receptor activity
0.78	GO:0004879	nuclear receptor activity
0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.55	GO:0005504	fatty acid binding
0.55	GO:0001102	RNA polymerase II activating transcription factor binding
0.55	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.54	GO:0001012	RNA polymerase II regulatory region DNA binding
0.53	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.52	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.47	GO:0070013	intracellular organelle lumen
0.43	GO:0044446	intracellular organelle part
0.39	GO:0005737	cytoplasm
0.33	GO:0005667	transcription factor complex

0.35

EC:3.1.2.2

GO:0016290

sp|P41236|IPP2_HUMAN
Protein phosphatase inhibitor 2
Search

PPP1R2

0.89	Cardiac inhibitor-2

0.83	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.70	GO:0009966	regulation of signal transduction
0.41	GO:0005977	glycogen metabolic process
0.35	GO:0032091	negative regulation of protein binding
0.35	GO:0006470	protein dephosphorylation
0.34	GO:0007568	aging
0.33	GO:0006869	lipid transport

0.83	GO:0004864	protein phosphatase inhibitor activity
0.36	GO:0005515	protein binding
0.35	GO:0004721	phosphoprotein phosphatase activity
0.34	GO:0031409	pigment binding
0.33	GO:0008289	lipid binding

0.51	GO:0000164	protein phosphatase type 1 complex
0.36	GO:0098723	skeletal muscle myofibril
0.35	GO:0043197	dendritic spine
0.35	GO:0030426	growth cone
0.30	GO:0016020	membrane

0.35

EC:3.1.3.16

GO:0004721

sp|P41238|ABEC1_HUMAN
C->U-editing enzyme APOBEC-1
Search

APOBEC1

0.94	Apolipoprotein B mRNA editing enzyme catalytic subunit 1

0.69	GO:0090310	negative regulation of methylation-dependent chromatin silencing
0.65	GO:0090209	negative regulation of triglyceride metabolic process
0.64	GO:0016554	cytidine to uridine editing
0.64	GO:0080111	DNA demethylation
0.63	GO:0048255	mRNA stabilization
0.62	GO:0010332	response to gamma radiation
0.59	GO:0006641	triglyceride metabolic process
0.58	GO:0016556	mRNA modification
0.57	GO:0042953	lipoprotein transport
0.56	GO:0042127	regulation of cell proliferation

0.71	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
0.63	GO:0008270	zinc ion binding
0.63	GO:0017091	AU-rich element binding
0.43	GO:0019904	protein domain specific binding
0.42	GO:0003729	mRNA binding
0.42	GO:0008047	enzyme activator activity
0.42	GO:0043021	ribonucleoprotein complex binding
0.42	GO:0019239	deaminase activity
0.35	GO:0008083	growth factor activity

0.42	GO:0005737	cytoplasm
0.39	GO:0005634	nucleus
0.36	GO:0031974	membrane-enclosed lumen
0.35	GO:0044446	intracellular organelle part
0.34	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.71

EC:3.5.4

GO:0016814

sp|P41240|CSK_HUMAN
Tyrosine-protein kinase CSK
Search

CSK

0.59	Tyrosine-protein kinase

0.75	GO:0018108	peptidyl-tyrosine phosphorylation
0.57	GO:0042997	negative regulation of Golgi to plasma membrane protein transport
0.51	GO:0042127	regulation of cell proliferation
0.48	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway
0.46	GO:0034332	adherens junction organization
0.45	GO:0060027	convergent extension involved in gastrulation
0.45	GO:0046777	protein autophosphorylation
0.44	GO:0001817	regulation of cytokine production
0.44	GO:0007417	central nervous system development
0.44	GO:0045087	innate immune response

0.79	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.55	GO:0034236	protein kinase A catalytic subunit binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0042802	identical protein binding
0.42	GO:0005102	receptor binding
0.35	GO:0070064	proline-rich region binding
0.35	GO:0019903	protein phosphatase binding
0.35	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

0.49	GO:0005911	cell-cell junction
0.44	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.35	GO:0098857	membrane microdomain
0.33	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.79

GO:0004715

sp|P41247|PLPL4_HUMAN
Patatin-like phospholipase domain-containing protein 4
Search

PNPLA4

0.97	Patatin like phospholipase domain containing 4

0.81	GO:0042572	retinol metabolic process
0.72	GO:0016042	lipid catabolic process
0.49	GO:0010898	positive regulation of triglyceride catabolic process
0.48	GO:0055088	lipid homeostasis
0.47	GO:0006641	triglyceride metabolic process
0.41	GO:0044248	cellular catabolic process
0.38	GO:0001889	liver development

0.85	GO:0050253	retinyl-palmitate esterase activity
0.78	GO:0004806	triglyceride lipase activity

0.47	GO:0005811	lipid droplet
0.45	GO:0005739	mitochondrion
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.85	EC:3.1.1	GO:0050253
0.85	KEGG:R02368	GO:0050253

sp|P41250|GARS_HUMAN
Glycine--tRNA ligase
Search

GARS

0.52	Glycyl-tRNA synthetase

0.77	GO:0006426	glycyl-tRNA aminoacylation
0.60	GO:0015960	diadenosine polyphosphate biosynthetic process
0.60	GO:0015965	diadenosine tetraphosphate metabolic process
0.47	GO:0070127	tRNA aminoacylation for mitochondrial protein translation

0.78	GO:0004820	glycine-tRNA ligase activity
0.57	GO:0004081	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0042802	identical protein binding
0.48	GO:0046983	protein dimerization activity

0.53	GO:0030424	axon
0.53	GO:0070062	extracellular exosome
0.52	GO:0030141	secretory granule
0.47	GO:0005829	cytosol
0.44	GO:0005739	mitochondrion
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part

0.78

EC:6.1.1.14

GO:0004820

sp|P41252|SYIC_HUMAN
Isoleucine--tRNA ligase, cytoplasmic
Search

IARS

0.67	Isoleucyl-tRNA synthetase

0.77	GO:0006428	isoleucyl-tRNA aminoacylation
0.72	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity
0.46	GO:1903670	regulation of sprouting angiogenesis
0.38	GO:0001649	osteoblast differentiation

0.78	GO:0004822	isoleucine-tRNA ligase activity
0.72	GO:0002161	aminoacyl-tRNA editing activity
0.68	GO:0000049	tRNA binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0051020	GTPase binding

0.53	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex
0.48	GO:0005737	cytoplasm
0.38	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.78	EC:6.1.1.5	GO:0004822
0.78	KEGG:R03656	GO:0004822

sp|P41271|NBL1_HUMAN
Neuroblastoma suppressor of tumorigenicity 1
Search

NBL1

0.97	Neuroblastoma suppressor of tumorigenicity 1

0.72	GO:0090027	negative regulation of monocyte chemotaxis
0.71	GO:0035582	sequestering of BMP in extracellular matrix
0.71	GO:0048263	determination of dorsal identity
0.63	GO:0045666	positive regulation of neuron differentiation
0.62	GO:0048812	neuron projection morphogenesis
0.61	GO:0010469	regulation of receptor activity
0.47	GO:0038098	sequestering of BMP from receptor via BMP binding
0.43	GO:0048752	semicircular canal morphogenesis
0.38	GO:0035148	tube formation

0.71	GO:0016015	morphogen activity
0.69	GO:0036122	BMP binding
0.44	GO:0042803	protein homodimerization activity
0.41	GO:0005125	cytokine activity

0.65	GO:0005576	extracellular region
0.30	GO:0016020	membrane

sp|P41273|TNFL9_HUMAN
Tumor necrosis factor ligand superfamily member 9
Search

TNFSF9

0.97	Tumor necrosis factor ligand superfamily member 9

0.74	GO:0006955	immune response
0.73	GO:0010469	regulation of receptor activity
0.64	GO:0045583	regulation of cytotoxic T cell differentiation
0.61	GO:0042104	positive regulation of activated T cell proliferation
0.59	GO:0045582	positive regulation of T cell differentiation
0.53	GO:0007267	cell-cell signaling
0.45	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.43	GO:0008283	cell proliferation
0.43	GO:0006915	apoptotic process

0.84	GO:0005164	tumor necrosis factor receptor binding
0.77	GO:0005125	cytokine activity

0.70	GO:0005615	extracellular space
0.43	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P41279|M3K8_HUMAN
Mitogen-activated protein kinase kinase kinase 8
Search

MAP3K8

0.97	Mitogen-activated protein kinase kinase kinase 8

0.63	GO:0006468	protein phosphorylation
0.49	GO:0032147	activation of protein kinase activity
0.48	GO:0031098	stress-activated protein kinase signaling cascade
0.46	GO:0007346	regulation of mitotic cell cycle
0.45	GO:0042981	regulation of apoptotic process
0.43	GO:0043406	positive regulation of MAP kinase activity
0.40	GO:0007049	cell cycle
0.36	GO:0002376	immune system process
0.35	GO:0070498	interleukin-1-mediated signaling pathway
0.34	GO:0050870	positive regulation of T cell activation

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0005057	signal transducer activity, downstream of receptor
0.39	GO:0000287	magnesium ion binding
0.33	GO:0005515	protein binding

0.49	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|P41439|FOLR3_HUMAN
Folate receptor gamma
Search

0.72	Folate receptor gamma

0.84	GO:0015884	folic acid transport
0.62	GO:0071231	cellular response to folic acid
0.54	GO:0061713	anterior neural tube closure
0.53	GO:0003147	neural crest cell migration involved in heart formation
0.53	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis
0.52	GO:0061626	pharyngeal arch artery morphogenesis
0.51	GO:0031103	axon regeneration
0.50	GO:0001947	heart looping
0.49	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
0.48	GO:0060828	regulation of canonical Wnt signaling pathway

0.84	GO:0008517	folic acid transmembrane transporter activity
0.81	GO:0005542	folic acid binding
0.62	GO:0061714	folic acid receptor activity
0.61	GO:0051870	methotrexate binding
0.33	GO:0008270	zinc ion binding

0.58	GO:0031362	anchored component of external side of plasma membrane
0.49	GO:0016324	apical plasma membrane
0.49	GO:0016323	basolateral plasma membrane
0.41	GO:0031526	brush border membrane
0.41	GO:0005634	nucleus
0.40	GO:0031982	vesicle
0.39	GO:0005576	extracellular region
0.37	GO:0012505	endomembrane system
0.35	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
0.35	GO:0019898	extrinsic component of membrane

sp|P41440|S19A1_HUMAN
Folate transporter 1
Search

SLC19A1

0.97	Solute carrier family 19 (Folate transporter), member 1

0.85	GO:0051958	methotrexate transport
0.85	GO:0015884	folic acid transport
0.81	GO:0035461	vitamin transmembrane transport
0.65	GO:0098838	reduced folate transmembrane transport
0.47	GO:0045117	azole transport
0.47	GO:0072531	pyrimidine-containing compound transmembrane transport
0.45	GO:0072348	sulfur compound transport
0.45	GO:0006855	drug transmembrane transport

0.86	GO:0015350	methotrexate transmembrane transporter activity
0.85	GO:0008517	folic acid transmembrane transporter activity
0.72	GO:0008518	reduced folate carrier activity
0.53	GO:0005542	folic acid binding
0.49	GO:0015234	thiamine transmembrane transporter activity

0.64	GO:0005887	integral component of plasma membrane
0.58	GO:0016323	basolateral plasma membrane
0.57	GO:0016324	apical plasma membrane

sp|P41567|EIF1_HUMAN
Eukaryotic translation initiation factor 1
Search

EIF1

0.92	Eukaryotic translation initiation factor 1

0.72	GO:0006413	translational initiation
0.48	GO:0006446	regulation of translational initiation
0.45	GO:0009048	dosage compensation by inactivation of X chromosome
0.34	GO:0006886	intracellular protein transport

0.73	GO:0003743	translation initiation factor activity
0.35	GO:0017137	Rab GTPase binding
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0016787	hydrolase activity

0.41	GO:0005634	nucleus
0.37	GO:0005737	cytoplasm
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016020	membrane

0.32

GO:0016787

sp|P41586|PACR_HUMAN
Pituitary adenylate cyclase-activating polypeptide type I receptor
Search

ADCYAP1R1

0.92	ADCYAP receptor type I

0.71	GO:0007166	cell surface receptor signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway

0.86

GO:0004999

vasoactive intestinal polypeptide receptor activity

0.63	GO:0043235	receptor complex
0.55	GO:0005886	plasma membrane
0.47	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0044425	membrane part

sp|P41587|VIPR2_HUMAN
Vasoactive intestinal polypeptide receptor 2
Search

VIPR2

0.95	Vasoactive intestinal polypeptide receptor

0.69	GO:0007166	cell surface receptor signaling pathway
0.69	GO:0007186	G-protein coupled receptor signaling pathway
0.42	GO:0007190	activation of adenylate cyclase activity
0.41	GO:0048662	negative regulation of smooth muscle cell proliferation
0.35	GO:0007267	cell-cell signaling

0.85

GO:0004999

vasoactive intestinal polypeptide receptor activity

0.50	GO:0005886	plasma membrane
0.35	GO:0043235	receptor complex
0.35	GO:0005929	cilium
0.30	GO:0044425	membrane part

sp|P41594|GRM5_HUMAN
Metabotropic glutamate receptor 5
Search

GRM5

0.92	Metabotropic glutamate receptor 5 splice variant f

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.65	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration
0.65	GO:1902938	regulation of intracellular calcium activated chloride channel activity
0.64	GO:0090647	modulation of age-related behavioral decline
0.62	GO:0048169	regulation of long-term neuronal synaptic plasticity
0.62	GO:1904646	cellular response to amyloid-beta
0.62	GO:0035584	calcium-mediated signaling using intracellular calcium source
0.61	GO:0061098	positive regulation of protein tyrosine kinase activity
0.60	GO:0007612	learning
0.58	GO:0007626	locomotory behavior

0.72	GO:0004930	G-protein coupled receptor activity
0.65	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
0.58	GO:0008066	glutamate receptor activity
0.42	GO:1990782	protein tyrosine kinase binding
0.40	GO:0031687	A2A adenosine receptor binding
0.39	GO:0030296	protein tyrosine kinase activator activity
0.38	GO:0030165	PDZ domain binding
0.37	GO:0005516	calmodulin binding

0.59	GO:0098794	postsynapse
0.57	GO:0097458	neuron part
0.55	GO:0032279	asymmetric synapse
0.55	GO:0005886	plasma membrane
0.54	GO:0120025	plasma membrane bounded cell projection
0.41	GO:0070062	extracellular exosome
0.40	GO:0005737	cytoplasm
0.36	GO:0044463	cell projection part
0.34	GO:0044422	organelle part
0.30	GO:0016021	integral component of membrane

sp|P41595|5HT2B_HUMAN
5-hydroxytryptamine receptor 2B
Search

HTR2B

0.97	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled

0.85	GO:0098664	G-protein coupled serotonin receptor signaling pathway
0.79	GO:0006939	smooth muscle contraction
0.78	GO:0042310	vasoconstriction
0.77	GO:0050795	regulation of behavior
0.73	GO:0007507	heart development
0.65	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process
0.62	GO:0051209	release of sequestered calcium ion into cytosol
0.61	GO:0071502	cellular response to temperature stimulus
0.61	GO:0070528	protein kinase C signaling
0.60	GO:0007202	activation of phospholipase C activity

0.85	GO:0099589	serotonin receptor activity
0.82	GO:0099528	G-protein coupled neurotransmitter receptor activity
0.82	GO:0008227	G-protein coupled amine receptor activity
0.64	GO:0051378	serotonin binding
0.59	GO:0001965	G-protein alpha-subunit binding
0.53	GO:0005096	GTPase activator activity
0.47	GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

0.65	GO:0005887	integral component of plasma membrane
0.50	GO:0005654	nucleoplasm
0.40	GO:0005737	cytoplasm
0.39	GO:0043005	neuron projection
0.38	GO:0045202	synapse
0.38	GO:0030054	cell junction
0.35	GO:0036477	somatodendritic compartment
0.35	GO:0120038	plasma membrane bounded cell projection part
0.35	GO:0044297	cell body
0.35	GO:0009897	external side of plasma membrane

sp|P41597|CCR2_HUMAN
C-C chemokine receptor type 2
Search

CCR5

0.87	C-C motif chemokine receptor 2

0.83	GO:0070098	chemokine-mediated signaling pathway
0.80	GO:0006954	inflammatory response
0.73	GO:0006955	immune response
0.71	GO:0006935	chemotaxis
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.61	GO:0090026	positive regulation of monocyte chemotaxis
0.60	GO:0001974	blood vessel remodeling
0.54	GO:2000464	positive regulation of astrocyte chemotaxis
0.52	GO:0043310	negative regulation of eosinophil degranulation
0.52	GO:2000473	positive regulation of hematopoietic stem cell migration

0.85	GO:0016493	C-C chemokine receptor activity
0.54	GO:0019957	C-C chemokine binding
0.53	GO:0031727	CCR2 chemokine receptor binding
0.40	GO:0003779	actin binding
0.37	GO:0042803	protein homodimerization activity
0.35	GO:0104005	hijacked molecular function
0.34	GO:0015026	coreceptor activity
0.34	GO:0004435	phosphatidylinositol phospholipase C activity

0.50	GO:0009897	external side of plasma membrane
0.40	GO:0005768	endosome
0.38	GO:0043204	perikaryon
0.37	GO:0030425	dendrite
0.37	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0005829	cytosol
0.35	GO:0005887	integral component of plasma membrane

0.34	EC:3.1.4.11	GO:0004435
0.34	KEGG:R03435	GO:0004435

sp|P41732|TSN7_HUMAN
Tetraspanin-7
Search

TSPAN7

0.59	Tetraspanin

0.44	GO:0007166	cell surface receptor signaling pathway
0.33	GO:0016032	viral process
0.33	GO:0006520	cellular amino acid metabolic process

0.35	GO:0005509	calcium ion binding
0.34	GO:0016743	carboxyl- or carbamoyltransferase activity
0.34	GO:0016597	amino acid binding

0.42	GO:0005887	integral component of plasma membrane
0.34	GO:0005576	extracellular region

0.34

EC:2.1.3

GO:0016743

sp|P41743|KPCI_HUMAN
Protein kinase C iota type
Search

PRKCI

0.60	Protein kinase C iota type

0.62	GO:0006468	protein phosphorylation
0.62	GO:0035556	intracellular signal transduction
0.60	GO:0007163	establishment or maintenance of cell polarity
0.59	GO:0042461	photoreceptor cell development
0.57	GO:0048592	eye morphogenesis
0.57	GO:0034351	negative regulation of glial cell apoptotic process
0.57	GO:0060252	positive regulation of glial cell proliferation
0.57	GO:2000353	positive regulation of endothelial cell apoptotic process
0.57	GO:0045216	cell-cell junction organization
0.55	GO:0046326	positive regulation of glucose import

0.82	GO:0004697	protein kinase C activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0046872	metal ion binding
0.50	GO:0005543	phospholipid binding
0.37	GO:0019904	protein domain specific binding

0.56	GO:0043220	Schmidt-Lanterman incisure
0.54	GO:0045171	intercellular bridge
0.53	GO:0016324	apical plasma membrane
0.48	GO:0015630	microtubule cytoskeleton
0.48	GO:0005829	cytosol
0.46	GO:0043296	apical junction complex
0.45	GO:0005634	nucleus
0.44	GO:0005913	cell-cell adherens junction
0.40	GO:0031226	intrinsic component of plasma membrane
0.39	GO:0070160	occluding junction

0.82

EC:2.7.11.13

GO:0004697

sp|P41968|MC3R_HUMAN
Melanocortin receptor 3
Search

MC3R

0.97	Melanocortin receptor 3

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.54	GO:0060259	regulation of feeding behavior
0.54	GO:0045475	locomotor rhythm
0.54	GO:0019933	cAMP-mediated signaling
0.53	GO:0032922	circadian regulation of gene expression
0.41	GO:0042309	homoiothermy
0.40	GO:0055078	sodium ion homeostasis
0.39	GO:0002027	regulation of heart rate
0.39	GO:0008217	regulation of blood pressure
0.35	GO:0030819	positive regulation of cAMP biosynthetic process

0.84	GO:0004977	melanocortin receptor activity
0.55	GO:0042923	neuropeptide binding
0.40	GO:0017046	peptide hormone binding
0.34	GO:0005515	protein binding

0.54	GO:0005886	plasma membrane
0.37	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

sp|P41970|ELK3_HUMAN
ETS domain-containing protein Elk-3
Search

ELK3

0.97	ETS domain-containing protein Elk-3

0.57	GO:0001525	angiogenesis
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0042060	wound healing
0.56	GO:0010468	regulation of gene expression
0.54	GO:0006366	transcription by RNA polymerase II
0.53	GO:0051254	positive regulation of RNA metabolic process
0.53	GO:0010557	positive regulation of macromolecule biosynthetic process
0.52	GO:0031328	positive regulation of cellular biosynthetic process
0.52	GO:0051253	negative regulation of RNA metabolic process

0.65	GO:0032422	purine-rich negative regulatory element binding
0.61	GO:0003700	DNA binding transcription factor activity
0.57	GO:0003714	transcription corepressor activity
0.57	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.34	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.50	GO:0031974	membrane-enclosed lumen
0.46	GO:0005739	mitochondrion
0.45	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|P42025|ACTY_HUMAN
Beta-centractin
Search

ACTR1B

0.93	Alpha-centractin

0.37	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.37	GO:0007283	spermatogenesis
0.35	GO:0097711	ciliary basal body-plasma membrane docking
0.35	GO:0043312	neutrophil degranulation
0.34	GO:0000086	G2/M transition of mitotic cell cycle
0.34	GO:0010389	regulation of G2/M transition of mitotic cell cycle
0.34	GO:0006888	ER to Golgi vesicle-mediated transport

0.52	GO:0032559	adenyl ribonucleotide binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding

0.82	GO:0005869	dynactin complex
0.57	GO:0005813	centrosome
0.52	GO:0099738	cell cortex region
0.52	GO:0043209	myelin sheath
0.38	GO:0002177	manchette
0.38	GO:0070062	extracellular exosome
0.37	GO:0005814	centriole
0.37	GO:0030137	COPI-coated vesicle
0.35	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0034774	secretory granule lumen

sp|P42081|CD86_HUMAN
T-lymphocyte activation antigen CD86
Search

CD86

0.96	T-lymphocyte activation antigen CD86

0.42	GO:0050778	positive regulation of immune response
0.42	GO:0008284	positive regulation of cell proliferation
0.42	GO:0050870	positive regulation of T cell activation
0.41	GO:0002376	immune system process
0.41	GO:0042129	regulation of T cell proliferation
0.41	GO:0071222	cellular response to lipopolysaccharide
0.41	GO:0002764	immune response-regulating signaling pathway
0.41	GO:0031349	positive regulation of defense response
0.41	GO:0002912	negative regulation of lymphocyte anergy
0.41	GO:0002665	negative regulation of T cell tolerance induction

0.39	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.39	GO:0104005	hijacked molecular function
0.38	GO:0015026	coreceptor activity
0.37	GO:0005515	protein binding

0.59	GO:0070062	extracellular exosome
0.42	GO:0009986	cell surface
0.40	GO:0098552	side of membrane
0.37	GO:0005886	plasma membrane
0.36	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

0.39	EC:2.7.1.153	GO:0046934
0.39	KEGG:R04545	GO:0046934

sp|P42126|ECI1_HUMAN
Enoyl-CoA delta isomerase 1, mitochondrial
Search

ECI1

0.93	Enoyl-CoA delta isomerase 1, mitochondrial

0.51

GO:0006635

fatty acid beta-oxidation

0.54	GO:0016853	isomerase activity
0.45	GO:0004300	enoyl-CoA hydratase activity
0.34	GO:0042802	identical protein binding
0.33	GO:0003723	RNA binding

0.44	GO:0005739	mitochondrion
0.43	GO:0019866	organelle inner membrane
0.36	GO:0070062	extracellular exosome
0.36	GO:0043233	organelle lumen

0.54

EC:5

GO:0016853

sp|P42127|ASIP_HUMAN
Agouti-signaling protein
Search

ASIP

0.97	Agouti signaling protein transcript variant 1A

0.76	GO:0009755	hormone-mediated signaling pathway
0.42	GO:0048023	positive regulation of melanin biosynthetic process
0.42	GO:0040030	regulation of molecular function, epigenetic
0.42	GO:0032438	melanosome organization
0.42	GO:0008343	adult feeding behavior
0.41	GO:0032402	melanosome transport
0.41	GO:0071514	genetic imprinting
0.41	GO:0042438	melanin biosynthetic process
0.36	GO:0006091	generation of precursor metabolites and energy

0.70

GO:0005102

receptor binding

0.66	GO:0005576	extracellular region
0.33	GO:0005622	intracellular

sp|P42166|LAP2A_HUMAN
Lamina-associated polypeptide 2, isoform alpha
Search

TMPO

0.95	Lamina-associated polypeptide 2, isoform alpha

0.42	GO:1903506	regulation of nucleic acid-templated transcription
0.42	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.42	GO:0010468	regulation of gene expression
0.38	GO:0031468	nuclear envelope reassembly
0.35	GO:1903047	mitotic cell cycle process
0.33	GO:0010469	regulation of receptor activity

0.54	GO:0045296	cadherin binding
0.53	GO:0003677	DNA binding
0.41	GO:0005521	lamin binding
0.37	GO:0042802	identical protein binding
0.35	GO:0003682	chromatin binding
0.34	GO:0005179	hormone activity

0.51	GO:0005635	nuclear envelope
0.49	GO:0000785	chromatin
0.37	GO:0031090	organelle membrane
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.35	GO:0000793	condensed chromosome
0.34	GO:0098827	endoplasmic reticulum subcompartment
0.30	GO:0016021	integral component of membrane

sp|P42224|STAT1_HUMAN
Signal transducer and activator of transcription 1-alpha/beta
Search

STAT1

0.70	Signal transducer and activator of transcription

0.60	GO:0060333	interferon-gamma-mediated signaling pathway
0.59	GO:0001937	negative regulation of endothelial cell proliferation
0.59	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
0.58	GO:0007259	JAK-STAT cascade
0.58	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.58	GO:0046725	negative regulation by virus of viral protein levels in host cell
0.57	GO:0016525	negative regulation of angiogenesis
0.57	GO:0071357	cellular response to type I interferon
0.57	GO:0010742	macrophage derived foam cell differentiation
0.56	GO:0006351	transcription, DNA-templated

0.63	GO:0004871	signal transducer activity
0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0035035	histone acetyltransferase binding
0.55	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
0.54	GO:1990841	promoter-specific chromatin binding
0.54	GO:0070491	repressing transcription factor binding
0.53	GO:0035257	nuclear hormone receptor binding
0.53	GO:0005164	tumor necrosis factor receptor binding
0.52	GO:0045296	cadherin binding
0.51	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.51	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0070013	intracellular organelle lumen
0.48	GO:0000785	chromatin
0.46	GO:0005829	cytosol
0.43	GO:0043234	protein complex
0.40	GO:0030425	dendrite
0.40	GO:0030424	axon

sp|P42226|STAT6_HUMAN
Signal transducer and activator of transcription 6
Search

STAT6

0.69	Signal transducer and activator of transcription

0.68	GO:0035771	interleukin-4-mediated signaling pathway
0.68	GO:0002296	T-helper 1 cell lineage commitment
0.67	GO:0048295	positive regulation of isotype switching to IgE isotypes
0.65	GO:0002829	negative regulation of type 2 immune response
0.65	GO:0033598	mammary gland epithelial cell proliferation
0.63	GO:0060443	mammary gland morphogenesis
0.59	GO:0042127	regulation of cell proliferation
0.58	GO:0000122	negative regulation of transcription by RNA polymerase II
0.57	GO:0045944	positive regulation of transcription by RNA polymerase II
0.57	GO:0006366	transcription by RNA polymerase II

0.64	GO:0004871	signal transducer activity
0.61	GO:0019903	protein phosphatase binding
0.61	GO:0003700	DNA binding transcription factor activity
0.59	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.55	GO:0042802	identical protein binding
0.34	GO:0035259	glucocorticoid receptor binding
0.32	GO:0046983	protein dimerization activity

0.61	GO:0005634	nucleus
0.54	GO:0000785	chromatin
0.54	GO:0005829	cytosol
0.53	GO:0070013	intracellular organelle lumen
0.52	GO:0012505	endomembrane system
0.48	GO:0031967	organelle envelope
0.48	GO:0031090	organelle membrane
0.39	GO:0098857	membrane microdomain
0.30	GO:0016021	integral component of membrane

sp|P42229|STA5A_HUMAN
Signal transducer and activator of transcription 5A
Search

STAT5A

0.70	Signal transducer and activator of transcription

0.86	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
0.57	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0008284	positive regulation of cell proliferation
0.56	GO:0046543	development of secondary female sexual characteristics
0.55	GO:0045647	negative regulation of erythrocyte differentiation
0.55	GO:0046544	development of secondary male sexual characteristics
0.55	GO:0001779	natural killer cell differentiation

0.64	GO:0004871	signal transducer activity
0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.51	GO:0035259	glucocorticoid receptor binding
0.47	GO:0001067	regulatory region nucleic acid binding
0.44	GO:0046983	protein dimerization activity
0.38	GO:0003682	chromatin binding
0.36	GO:0004713	protein tyrosine kinase activity

0.61	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.44	GO:0070013	intracellular organelle lumen
0.40	GO:0044446	intracellular organelle part
0.30	GO:0044425	membrane part

0.36

GO:0004713

sp|P42261|GRIA1_HUMAN
Glutamate receptor 1
Search

GRIA1

0.93	Glutamate ionotropic receptor AMPA type subunit 1

0.79	GO:0060079	excitatory postsynaptic potential
0.76	GO:0035235	ionotropic glutamate receptor signaling pathway
0.59	GO:0034220	ion transmembrane transport
0.56	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration
0.54	GO:0060292	long term synaptic depression
0.53	GO:0031623	receptor internalization
0.53	GO:0007616	long-term memory
0.37	GO:0060992	response to fungicide
0.37	GO:0010226	response to lithium ion
0.36	GO:0001919	regulation of receptor recycling

0.81	GO:0005234	extracellularly glutamate-gated ion channel activity
0.76	GO:0004970	ionotropic glutamate receptor activity
0.56	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
0.54	GO:0099094	ligand-gated cation channel activity
0.51	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
0.38	GO:0001540	amyloid-beta binding
0.38	GO:0030165	PDZ domain binding
0.36	GO:0005272	sodium channel activity
0.36	GO:0098782	mechanosensitived potassium channel activity
0.36	GO:0031698	beta-2 adrenergic receptor binding

0.78	GO:0045211	postsynaptic membrane
0.73	GO:0030054	cell junction
0.57	GO:0032281	AMPA glutamate receptor complex
0.55	GO:0044308	axonal spine
0.55	GO:0032591	dendritic spine membrane
0.53	GO:0014069	postsynaptic density
0.51	GO:0008021	synaptic vesicle
0.51	GO:0055037	recycling endosome
0.51	GO:0043025	neuronal cell body
0.49	GO:0009986	cell surface

sp|P42262|GRIA2_HUMAN
Glutamate receptor 2
Search

GRIA2

0.93	Glutamate ionotropic receptor AMPA type subunit 2

0.79	GO:0060079	excitatory postsynaptic potential
0.76	GO:0035235	ionotropic glutamate receptor signaling pathway
0.60	GO:0034220	ion transmembrane transport
0.41	GO:0048899	anterior lateral line development
0.40	GO:0048915	posterior lateral line system development
0.39	GO:0014032	neural crest cell development
0.39	GO:0048701	embryonic cranial skeleton morphogenesis
0.38	GO:0007399	nervous system development
0.35	GO:0060992	response to fungicide
0.35	GO:0010226	response to lithium ion

0.81	GO:0005234	extracellularly glutamate-gated ion channel activity
0.76	GO:0004970	ionotropic glutamate receptor activity
0.45	GO:0099094	ligand-gated cation channel activity
0.38	GO:0005272	sodium channel activity
0.38	GO:0098782	mechanosensitived potassium channel activity
0.37	GO:0001540	amyloid-beta binding
0.35	GO:0016934	extracellularly glycine-gated chloride channel activity
0.35	GO:0005515	protein binding
0.35	GO:0005246	calcium channel regulator activity

0.78	GO:0045211	postsynaptic membrane
0.74	GO:0030054	cell junction
0.47	GO:0032281	AMPA glutamate receptor complex
0.38	GO:0005789	endoplasmic reticulum membrane
0.37	GO:0099240	intrinsic component of synaptic membrane
0.37	GO:0106003	amyloid-beta complex
0.37	GO:0036477	somatodendritic compartment
0.37	GO:0043005	neuron projection
0.36	GO:0014069	postsynaptic density
0.36	GO:0031410	cytoplasmic vesicle

sp|P42263|GRIA3_HUMAN
Glutamate receptor 3
Search

GRIA3

0.65	Glutamate ionotropic receptor AMPA type subunit 3

0.79	GO:0060079	excitatory postsynaptic potential
0.76	GO:0035235	ionotropic glutamate receptor signaling pathway
0.59	GO:0034220	ion transmembrane transport
0.35	GO:0060992	response to fungicide
0.35	GO:0010226	response to lithium ion
0.35	GO:0001919	regulation of receptor recycling

0.81	GO:0005234	extracellularly glutamate-gated ion channel activity
0.76	GO:0004970	ionotropic glutamate receptor activity
0.55	GO:0099094	ligand-gated cation channel activity
0.37	GO:0001540	amyloid-beta binding
0.35	GO:0030165	PDZ domain binding

0.78	GO:0045211	postsynaptic membrane
0.74	GO:0030054	cell junction
0.57	GO:0032281	AMPA glutamate receptor complex
0.35	GO:0043083	synaptic cleft
0.35	GO:0043198	dendritic shaft
0.35	GO:0043204	perikaryon
0.35	GO:0043195	terminal bouton
0.35	GO:0043197	dendritic spine
0.35	GO:0030666	endocytic vesicle membrane
0.35	GO:0014069	postsynaptic density

sp|P42285|SK2L2_HUMAN
Superkiller viralicidic activity 2-like 2
Search

SKIV2L2

0.94	Putative cytoplasmic exosomal rna helicase ski2 dead-box superfamily

0.75	GO:0000460	maturation of 5.8S rRNA
0.72	GO:0006401	RNA catabolic process
0.40	GO:0031101	fin regeneration
0.39	GO:0051781	positive regulation of cell division

0.76	GO:0003724	RNA helicase activity
0.59	GO:0003723	RNA binding
0.56	GO:0008186	RNA-dependent ATPase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0070035	purine NTP-dependent helicase activity

0.75	GO:0071013	catalytic step 2 spliceosome
0.73	GO:0000178	exosome (RNase complex)

0.76

GO:0003724

sp|P42330|AK1C3_HUMAN
Aldo-keto reductase family 1 member C3
Search

0.96	3-hydroxyhexobarbital dehydrogenase

0.53	GO:0055114	oxidation-reduction process
0.51	GO:0044597	daunorubicin metabolic process
0.49	GO:0071395	cellular response to jasmonic acid stimulus
0.48	GO:0044598	doxorubicin metabolic process
0.47	GO:0008202	steroid metabolic process
0.45	GO:1900053	negative regulation of retinoic acid biosynthetic process
0.45	GO:0071799	cellular response to prostaglandin D stimulus
0.45	GO:0016488	farnesol catabolic process
0.45	GO:2000224	regulation of testosterone biosynthetic process
0.44	GO:0042574	retinal metabolic process

0.54	GO:0016491	oxidoreductase activity
0.41	GO:0032052	bile acid binding
0.35	GO:0015125	bile acid transmembrane transporter activity
0.34	GO:0005496	steroid binding
0.34	GO:0070401	NADP+ binding
0.34	GO:0070402	NADPH binding
0.33	GO:0005515	protein binding

0.39	GO:0005829	cytosol
0.39	GO:0070062	extracellular exosome
0.38	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.54

GO:0016491

sp|P42331|RHG25_HUMAN
Rho GTPase-activating protein 25
Search

ARHGAP25

0.93	Rho GTPase-activating protein 25

0.68	GO:0043547	positive regulation of GTPase activity
0.61	GO:0007165	signal transduction
0.57	GO:0006911	phagocytosis, engulfment
0.56	GO:0051058	negative regulation of small GTPase mediated signal transduction
0.51	GO:0007015	actin filament organization

0.69	GO:0005096	GTPase activator activity
0.32	GO:0005543	phospholipid binding

0.58	GO:0001891	phagocytic cup
0.34	GO:0005829	cytosol

sp|P42336|PK3CA_HUMAN
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Search

PIK3CA

0.95	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

0.83	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
0.81	GO:0048015	phosphatidylinositol-mediated signaling
0.75	GO:0046854	phosphatidylinositol phosphorylation
0.59	GO:0044029	hypomethylation of CpG island
0.57	GO:2000653	regulation of genetic imprinting
0.57	GO:2000270	negative regulation of fibroblast apoptotic process
0.56	GO:2000811	negative regulation of anoikis
0.56	GO:0097009	energy homeostasis
0.55	GO:0060612	adipose tissue development
0.55	GO:0043491	protein kinase B signaling

0.84	GO:0016303	1-phosphatidylinositol-3-kinase activity
0.56	GO:0043560	insulin receptor substrate binding
0.53	GO:0030295	protein kinase activator activity
0.52	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.51	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity
0.37	GO:0004674	protein serine/threonine kinase activity
0.36	GO:1902379	chemoattractant activity involved in axon guidance
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0097367	carbohydrate derivative binding
0.34	GO:0008144	drug binding

0.62	GO:0005943	phosphatidylinositol 3-kinase complex, class IA
0.53	GO:0030027	lamellipodium
0.45	GO:0005622	intracellular
0.39	GO:0005886	plasma membrane
0.35	GO:0090723	growth cone part
0.30	GO:0016021	integral component of membrane

0.84	EC:2.7.1.137	GO:0016303
0.84	KEGG:R03362	GO:0016303

sp|P42338|PK3CB_HUMAN
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Search

PIK3CB

0.97	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

0.80	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
0.80	GO:0014065	phosphatidylinositol 3-kinase signaling
0.73	GO:0046854	phosphatidylinositol phosphorylation
0.62	GO:0033031	positive regulation of neutrophil apoptotic process
0.58	GO:0001952	regulation of cell-matrix adhesion
0.54	GO:0030168	platelet activation
0.52	GO:0040016	embryonic cleavage
0.51	GO:0010628	positive regulation of gene expression
0.51	GO:0060055	angiogenesis involved in wound healing
0.51	GO:0001935	endothelial cell proliferation

0.82	GO:0035004	phosphatidylinositol 3-kinase activity
0.80	GO:0052742	phosphatidylinositol kinase activity
0.52	GO:0052813	phosphatidylinositol bisphosphate kinase activity
0.51	GO:0043560	insulin receptor substrate binding
0.48	GO:0016307	phosphatidylinositol phosphate kinase activity
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0097367	carbohydrate derivative binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.56	GO:0030496	midbody
0.51	GO:0005730	nucleolus
0.48	GO:0005942	phosphatidylinositol 3-kinase complex
0.39	GO:0005886	plasma membrane
0.37	GO:0005737	cytoplasm
0.35	GO:0005903	brush border
0.35	GO:0120038	plasma membrane bounded cell projection part

0.82

GO:0035004

sp|P42345|MTOR_HUMAN
Serine/threonine-protein kinase mTOR
Search

MTOR

0.91	Serine/threonine-protein kinase mTOR

0.70	GO:1903691	positive regulation of wound healing, spreading of epidermal cells
0.69	GO:0051534	negative regulation of NFAT protein import into nucleus
0.68	GO:0050882	voluntary musculoskeletal movement
0.68	GO:0071233	cellular response to leucine
0.68	GO:1990253	cellular response to leucine starvation
0.68	GO:0051549	positive regulation of keratinocyte migration
0.68	GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
0.68	GO:0048714	positive regulation of oligodendrocyte differentiation
0.67	GO:0045792	negative regulation of cell size
0.67	GO:0010592	positive regulation of lamellipodium assembly

0.70	GO:0004674	protein serine/threonine kinase activity
0.70	GO:0044877	macromolecular complex binding
0.68	GO:0001156	TFIIIC-class transcription factor binding
0.67	GO:0001031	RNA polymerase III type 2 promoter DNA binding
0.67	GO:0001030	RNA polymerase III type 1 promoter DNA binding
0.67	GO:0001032	RNA polymerase III type 3 promoter DNA binding
0.64	GO:0051219	phosphoprotein binding
0.57	GO:0042802	identical protein binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0008144	drug binding

0.64	GO:0016605	PML body
0.63	GO:0031931	TORC1 complex
0.62	GO:0031932	TORC2 complex
0.61	GO:0030425	dendrite
0.61	GO:0005764	lysosome
0.54	GO:0005829	cytosol
0.53	GO:0012505	endomembrane system
0.43	GO:0043025	neuronal cell body
0.42	GO:0005741	mitochondrial outer membrane
0.41	GO:0098852	lytic vacuole membrane

0.70

GO:0004674

sp|P42356|PI4KA_HUMAN
Phosphatidylinositol 4-kinase alpha
Search

PI4KA

0.94	Phosphatidylinositol 4-kinase III alpha

0.80	GO:0048015	phosphatidylinositol-mediated signaling
0.75	GO:0046854	phosphatidylinositol phosphorylation
0.54	GO:0046786	viral replication complex formation and maintenance
0.45	GO:0039694	viral RNA genome replication
0.45	GO:0030036	actin cytoskeleton organization
0.44	GO:0044803	multi-organism membrane organization
0.43	GO:0035118	embryonic pectoral fin morphogenesis
0.35	GO:0006661	phosphatidylinositol biosynthetic process

0.59	GO:0016301	kinase activity
0.49	GO:0045296	cadherin binding
0.41	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.35	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.53	GO:0019034	viral replication complex
0.45	GO:0005622	intracellular
0.41	GO:0005886	plasma membrane
0.37	GO:0005925	focal adhesion
0.37	GO:0070062	extracellular exosome
0.37	GO:0098805	whole membrane
0.36	GO:0098588	bounding membrane of organelle
0.30	GO:0031224	intrinsic component of membrane

0.41

GO:0016773

sp|P42357|HUTH_HUMAN
Histidine ammonia-lyase
Search

HAL

0.58	Histidine ammonia-lyase

0.76	GO:0019557	histidine catabolic process to glutamate and formate
0.76	GO:0043606	formamide metabolic process
0.44	GO:0060218	hematopoietic stem cell differentiation

0.80

GO:0004397

histidine ammonia-lyase activity

0.48

GO:0005737

cytoplasm

0.80

EC:4.3.1.3

GO:0004397

sp|P42566|EPS15_HUMAN
Epidermal growth factor receptor substrate 15
Search

EPS15

0.93	Epidermal growth factor receptor pathway substrate 15

0.62	GO:0006895	Golgi to endosome transport
0.60	GO:0048268	clathrin coat assembly
0.54	GO:0019065	receptor-mediated endocytosis of virus by host cell
0.47	GO:0001921	positive regulation of receptor recycling
0.45	GO:0032456	endocytic recycling
0.43	GO:0042127	regulation of cell proliferation
0.39	GO:0016050	vesicle organization
0.38	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
0.38	GO:0007173	epidermal growth factor receptor signaling pathway
0.37	GO:0048488	synaptic vesicle endocytosis

0.69	GO:0005509	calcium ion binding
0.61	GO:0031593	polyubiquitin modification-dependent protein binding
0.59	GO:0045296	cadherin binding
0.55	GO:0042802	identical protein binding
0.39	GO:0017124	SH3 domain binding
0.35	GO:0051082	unfolded protein binding

0.62	GO:0016235	aggresome
0.62	GO:0060170	ciliary membrane
0.62	GO:0030122	AP-2 adaptor complex
0.52	GO:0005829	cytosol
0.46	GO:0009925	basal plasma membrane
0.45	GO:0043231	intracellular membrane-bounded organelle
0.44	GO:0016324	apical plasma membrane
0.44	GO:0005769	early endosome
0.39	GO:0010008	endosome membrane
0.36	GO:0045202	synapse

sp|P42568|AF9_HUMAN
Protein AF-9
Search

MLLT3

0.97	MLLT3, super elongation complex subunit

0.75	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway
0.74	GO:0007379	segment specification
0.69	GO:0090090	negative regulation of canonical Wnt signaling pathway
0.69	GO:0009952	anterior/posterior pattern specification
0.62	GO:0045893	positive regulation of transcription, DNA-templated
0.39	GO:0006469	negative regulation of protein kinase activity

0.70	GO:0070577	lysine-acetylated histone binding
0.64	GO:0003682	chromatin binding

0.67	GO:0008023	transcription elongation factor complex
0.39	GO:0001650	fibrillar center
0.38	GO:0070062	extracellular exosome
0.37	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|P42574|CASP3_HUMAN
Caspase-3
Search

CASP3

0.95	Caspase 3, apoptosis-related cysteine peptidase a

0.61	GO:0006508	proteolysis
0.59	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress
0.59	GO:0030216	keratinocyte differentiation
0.59	GO:0097194	execution phase of apoptosis
0.58	GO:0030218	erythrocyte differentiation
0.58	GO:0072734	cellular response to staurosporine
0.57	GO:0034349	glial cell apoptotic process
0.57	GO:0046007	negative regulation of activated T cell proliferation
0.56	GO:0030889	negative regulation of B cell proliferation
0.56	GO:0048011	neurotrophin TRK receptor signaling pathway

0.75	GO:0004197	cysteine-type endopeptidase activity
0.54	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
0.48	GO:0004190	aspartic-type endopeptidase activity
0.40	GO:0016005	phospholipase A2 activator activity
0.39	GO:0005123	death receptor binding
0.38	GO:0002020	protease binding
0.37	GO:0032403	protein complex binding
0.36	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
0.35	GO:1990525	BIR domain binding
0.34	GO:0004252	serine-type endopeptidase activity

0.47	GO:0005829	cytosol
0.44	GO:0005634	nucleus
0.39	GO:0031264	death-inducing signaling complex
0.38	GO:0098857	membrane microdomain
0.35	GO:0097179	protease inhibitor complex
0.34	GO:0043197	dendritic spine
0.34	GO:0014069	postsynaptic density
0.34	GO:0070013	intracellular organelle lumen
0.33	GO:0044446	intracellular organelle part

0.75

GO:0004197

sp|P42575|CASP2_HUMAN
Caspase-2
Search

CASP2

0.96	Caspase 2, apoptosis-related cysteine peptidase

0.85	GO:0097194	execution phase of apoptosis
0.73	GO:0042981	regulation of apoptotic process
0.60	GO:0035234	ectopic germ cell programmed cell death
0.60	GO:0006508	proteolysis
0.60	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
0.59	GO:0038034	signal transduction in absence of ligand
0.58	GO:0071260	cellular response to mechanical stimulus
0.58	GO:0097191	extrinsic apoptotic signaling pathway
0.56	GO:0043068	positive regulation of programmed cell death
0.53	GO:0009967	positive regulation of signal transduction

0.85	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis
0.53	GO:0019904	protein domain specific binding
0.52	GO:0042802	identical protein binding
0.34	GO:0019899	enzyme binding

0.46	GO:0005634	nucleus
0.40	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|P42658|DPP6_HUMAN
Dipeptidyl aminopeptidase-like protein 6
Search

DPP6

0.92	Dipeptidyl peptidase like 6

0.58	GO:0006508	proteolysis
0.54	GO:1901379	regulation of potassium ion transmembrane transport
0.46	GO:0065009	regulation of molecular function
0.41	GO:0072659	protein localization to plasma membrane
0.37	GO:0019228	neuronal action potential
0.37	GO:0043268	positive regulation of potassium ion transport
0.37	GO:1904064	positive regulation of cation transmembrane transport
0.35	GO:1903078	positive regulation of protein localization to plasma membrane
0.35	GO:0048522	positive regulation of cellular process

0.64	GO:0017171	serine hydrolase activity
0.60	GO:0070011	peptidase activity, acting on L-amino acid peptides
0.55	GO:0015459	potassium channel regulator activity
0.34	GO:0005515	protein binding

0.51	GO:0008076	voltage-gated potassium channel complex
0.37	GO:0070062	extracellular exosome
0.35	GO:0043025	neuronal cell body
0.34	GO:0009986	cell surface

sp|P42677|RS27_HUMAN
40S ribosomal protein S27
Search

RPS27

0.71	40S ribosomal protein S27

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.48	GO:0000028	ribosomal small subunit assembly
0.47	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
0.46	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.46	GO:0031571	mitotic G1 DNA damage checkpoint
0.45	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
0.43	GO:0045727	positive regulation of translation

0.64	GO:0003735	structural constituent of ribosome
0.54	GO:0046872	metal ion binding
0.47	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
0.47	GO:0008494	translation activator activity
0.35	GO:0003723	RNA binding
0.34	GO:0005515	protein binding
0.34	GO:0008502	melatonin receptor activity
0.32	GO:0003677	DNA binding
0.32	GO:0016787	hydrolase activity

0.61	GO:0005840	ribosome
0.46	GO:0044445	cytosolic part
0.42	GO:0005634	nucleus
0.40	GO:0044446	intracellular organelle part
0.33	GO:0043233	organelle lumen
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016787

sp|P42679|MATK_HUMAN
Megakaryocyte-associated tyrosine-protein kinase
Search

MATK

0.58	Megakaryocyte-associated tyrosine-protein kinase

0.75	GO:0018108	peptidyl-tyrosine phosphorylation
0.45	GO:0046777	protein autophosphorylation
0.44	GO:0045087	innate immune response
0.44	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.43	GO:0042127	regulation of cell proliferation
0.42	GO:0030154	cell differentiation
0.36	GO:0009888	tissue development
0.35	GO:0008283	cell proliferation
0.34	GO:0048522	positive regulation of cellular process
0.34	GO:0007369	gastrulation

0.78	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0005102	receptor binding
0.33	GO:1904929	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
0.33	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.32	GO:0008270	zinc ion binding
0.31	GO:0003676	nucleic acid binding

0.44	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.35	GO:0005856	cytoskeleton
0.34	GO:0005829	cytosol
0.32	GO:0005887	integral component of plasma membrane

0.78

GO:0004715

sp|P42680|TEC_HUMAN
Tyrosine-protein kinase Tec
Search

TEC

0.59	Tyrosine-protein kinase

0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.60	GO:0010543	regulation of platelet activation
0.58	GO:0046777	protein autophosphorylation
0.57	GO:0035556	intracellular signal transduction
0.56	GO:0050853	B cell receptor signaling pathway
0.55	GO:0007229	integrin-mediated signaling pathway
0.55	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
0.49	GO:0042246	tissue regeneration
0.46	GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway
0.46	GO:0045087	innate immune response

0.80	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0005102	receptor binding
0.43	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.43	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding

0.48	GO:0005856	cytoskeleton
0.46	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.38	GO:0005634	nucleus
0.37	GO:0005911	cell-cell junction
0.35	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.80

GO:0004715

sp|P42681|TXK_HUMAN
Tyrosine-protein kinase TXK
Search

TXK

0.59	Tyrosine-protein kinase

0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.59	GO:0046777	protein autophosphorylation
0.59	GO:0060332	positive regulation of response to interferon-gamma
0.58	GO:0060334	regulation of interferon-gamma-mediated signaling pathway
0.57	GO:0001961	positive regulation of cytokine-mediated signaling pathway
0.57	GO:0032729	positive regulation of interferon-gamma production
0.54	GO:0010543	regulation of platelet activation
0.53	GO:0051173	positive regulation of nitrogen compound metabolic process
0.53	GO:0010604	positive regulation of macromolecule metabolic process
0.52	GO:0031325	positive regulation of cellular metabolic process

0.80	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.54	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0005102	receptor binding

0.46	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.45	GO:0005634	nucleus
0.42	GO:0005856	cytoskeleton
0.39	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.80

GO:0004715

sp|P42684|ABL2_HUMAN
Abelson tyrosine-protein kinase 2
Search

ABL2

0.59	Tyrosine-protein kinase

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.59	GO:0010863	positive regulation of phospholipase C activity
0.58	GO:0071300	cellular response to retinoic acid
0.57	GO:0051353	positive regulation of oxidoreductase activity
0.56	GO:0010976	positive regulation of neuron projection development
0.55	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.45	GO:0046777	protein autophosphorylation
0.45	GO:0045087	innate immune response
0.44	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.44	GO:0042127	regulation of cell proliferation

0.80	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.57	GO:0001784	phosphotyrosine residue binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.51	GO:0030145	manganese ion binding
0.47	GO:0000287	magnesium ion binding
0.43	GO:0005102	receptor binding
0.36	GO:0003785	actin monomer binding

0.45	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.38	GO:0001891	phagocytic cup
0.37	GO:0043197	dendritic spine
0.37	GO:0015629	actin cytoskeleton
0.37	GO:0030027	lamellipodium
0.34	GO:0031410	cytoplasmic vesicle
0.34	GO:0005829	cytosol

0.80

GO:0004715

sp|P42685|FRK_HUMAN
Tyrosine-protein kinase FRK
Search

FRK

0.56	Tyrosine-protein kinase

0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.51	GO:0000122	negative regulation of transcription by RNA polymerase II
0.46	GO:0046777	protein autophosphorylation
0.45	GO:0045087	innate immune response
0.45	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.45	GO:0016477	cell migration
0.44	GO:0042127	regulation of cell proliferation
0.43	GO:0030154	cell differentiation

0.80	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0005102	receptor binding

0.47	GO:0005829	cytosol
0.45	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.44	GO:0005634	nucleus

0.80

GO:0004715

sp|P42694|HELZ_HUMAN
Probable helicase with zinc finger domain
Search

HELZ

0.84	Helicase with zinc finger

0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:2001141	regulation of RNA biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.57	GO:0004386	helicase activity
0.53	GO:0046872	metal ion binding
0.36	GO:0005515	protein binding
0.35	GO:0030554	adenyl nucleotide binding
0.35	GO:0097367	carbohydrate derivative binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0003723	RNA binding
0.34	GO:0003677	DNA binding
0.32	GO:0003700	DNA binding transcription factor activity

0.35	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|P42695|CNDD3_HUMAN
Condensin-2 complex subunit D3
Search

NCAPD3

0.95	Non-SMC condensin II complex subunit D3

0.82	GO:0007076	mitotic chromosome condensation
0.54	GO:0010032	meiotic chromosome condensation
0.51	GO:0051304	chromosome separation
0.39	GO:0045132	meiotic chromosome segregation
0.36	GO:0051301	cell division
0.32	GO:0006468	protein phosphorylation
0.31	GO:0043043	peptide biosynthetic process
0.31	GO:0010467	gene expression
0.31	GO:0009059	macromolecule biosynthetic process

0.62	GO:0140034	methylation-dependent protein binding
0.61	GO:0042393	histone binding
0.49	GO:0003682	chromatin binding
0.32	GO:0004674	protein serine/threonine kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.31	GO:0003735	structural constituent of ribosome

0.84	GO:0000799	nuclear condensin complex
0.63	GO:0031618	nuclear pericentric heterochromatin
0.53	GO:0005654	nucleoplasm
0.51	GO:0000779	condensed chromosome, centromeric region
0.41	GO:0042585	germinal vesicle
0.39	GO:0000776	kinetochore
0.31	GO:0005840	ribosome
0.30	GO:0016020	membrane

0.32

GO:0004674

sp|P42696|RBM34_HUMAN
RNA-binding protein 34
Search

RBM34

0.83	RNA binding motif protein 34

0.40	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression

0.59	GO:0003723	RNA binding
0.33	GO:0003677	DNA binding

0.45	GO:0005730	nucleolus
0.39	GO:0030684	preribosome
0.30	GO:0031224	intrinsic component of membrane

sp|P42701|I12R1_HUMAN
Interleukin-12 receptor subunit beta-1
Search

IL12RB1

0.97	Interleukin-12 receptor subunit beta-1

0.73	GO:0038155	interleukin-23-mediated signaling pathway
0.72	GO:0035722	interleukin-12-mediated signaling pathway
0.70	GO:0002827	positive regulation of T-helper 1 type immune response
0.69	GO:0042104	positive regulation of activated T cell proliferation
0.69	GO:0002230	positive regulation of defense response to virus by host
0.68	GO:0032729	positive regulation of interferon-gamma production
0.67	GO:0071346	cellular response to interferon-gamma
0.45	GO:2000330	positive regulation of T-helper 17 cell lineage commitment
0.44	GO:0043382	positive regulation of memory T cell differentiation
0.43	GO:0001916	positive regulation of T cell mediated cytotoxicity

0.75	GO:0016517	interleukin-12 receptor activity
0.74	GO:0042020	interleukin-23 receptor activity
0.74	GO:0042019	interleukin-23 binding
0.71	GO:0005143	interleukin-12 receptor binding

0.74	GO:0042022	interleukin-12 receptor complex
0.73	GO:0072536	interleukin-23 receptor complex
0.40	GO:0009897	external side of plasma membrane

sp|P42702|LIFR_HUMAN
Leukemia inhibitory factor receptor
Search

LIFR

0.95	Leukemia inhibitory factor receptor alpha

0.79	GO:0019221	cytokine-mediated signaling pathway
0.54	GO:0048861	leukemia inhibitory factor signaling pathway
0.48	GO:0008284	positive regulation of cell proliferation
0.38	GO:0010656	negative regulation of muscle cell apoptotic process
0.38	GO:0031100	animal organ regeneration
0.37	GO:0001959	regulation of cytokine-mediated signaling pathway
0.37	GO:0048812	neuron projection morphogenesis
0.37	GO:0014070	response to organic cyclic compound

0.80	GO:0004896	cytokine receptor activity
0.54	GO:0005127	ciliary neurotrophic factor receptor binding
0.50	GO:0019838	growth factor binding
0.38	GO:0019955	cytokine binding
0.36	GO:0046982	protein heterodimerization activity

0.48	GO:0043235	receptor complex
0.45	GO:0005615	extracellular space
0.41	GO:1903561	extracellular vesicle
0.38	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P42704|LPPRC_HUMAN
Leucine-rich PPR motif-containing protein, mitochondrial
Search

LRPPRC

0.95	Leucine rich pentatricopeptide repeat containing

0.87	GO:0000961	negative regulation of mitochondrial RNA catabolic process
0.84	GO:0070129	regulation of mitochondrial translation
0.50	GO:0009451	RNA modification
0.49	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.81	GO:0048487	beta-tubulin binding
0.76	GO:0031625	ubiquitin protein ligase binding
0.72	GO:0003697	single-stranded DNA binding
0.59	GO:0003723	RNA binding
0.50	GO:0004519	endonuclease activity

0.80	GO:0042645	mitochondrial nucleoid
0.76	GO:0048471	perinuclear region of cytoplasm
0.76	GO:0000794	condensed nuclear chromosome
0.71	GO:0005874	microtubule
0.60	GO:0030529	intracellular ribonucleoprotein complex

sp|P42765|THIM_HUMAN
3-ketoacyl-CoA thiolase, mitochondrial
Search

ACAA2

0.48	Acetyl-Coenzyme A acyltransferase 2

0.58	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process
0.57	GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
0.54	GO:0071456	cellular response to hypoxia
0.45	GO:0006635	fatty acid beta-oxidation
0.35	GO:0006695	cholesterol biosynthetic process
0.34	GO:0006084	acetyl-CoA metabolic process
0.34	GO:0007018	microtubule-based movement

0.64	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
0.35	GO:0003779	actin binding
0.35	GO:0003774	motor activity
0.34	GO:0008017	microtubule binding
0.34	GO:0003723	RNA binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.44	GO:0005739	mitochondrion
0.43	GO:0019866	organelle inner membrane
0.36	GO:0070062	extracellular exosome
0.35	GO:0016459	myosin complex
0.35	GO:0031974	membrane-enclosed lumen
0.30	GO:0031224	intrinsic component of membrane

0.64

GO:0016747

sp|P42766|RL35_HUMAN
60S ribosomal protein L35
Search

RPL35

0.76	Ribosomal protein L35

0.59	GO:0043043	peptide biosynthetic process
0.54	GO:0044267	cellular protein metabolic process
0.53	GO:0010467	gene expression
0.52	GO:0009059	macromolecule biosynthetic process
0.47	GO:0042273	ribosomal large subunit biogenesis
0.44	GO:0016072	rRNA metabolic process
0.41	GO:0030218	erythrocyte differentiation
0.40	GO:0043009	chordate embryonic development
0.39	GO:0051726	regulation of cell cycle
0.35	GO:0071493	cellular response to UV-B

0.62	GO:0003735	structural constituent of ribosome
0.47	GO:0003729	mRNA binding
0.34	GO:0043021	ribonucleoprotein complex binding
0.33	GO:0044212	transcription regulatory region DNA binding
0.32	GO:0003700	DNA binding transcription factor activity

0.61	GO:0005840	ribosome
0.46	GO:0044445	cytosolic part
0.40	GO:0044446	intracellular organelle part
0.34	GO:0005791	rough endoplasmic reticulum
0.34	GO:0098562	cytoplasmic side of membrane
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.34	GO:0005634	nucleus
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0043233	organelle lumen
0.30	GO:0031224	intrinsic component of membrane

sp|P42768|WASP_HUMAN
Wiskott-Aldrich syndrome protein
Search

WASL

0.89	Wiskott-Aldrich syndrome like

0.85	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation
0.75	GO:0007015	actin filament organization
0.57	GO:2000146	negative regulation of cell motility
0.55	GO:1903526	negative regulation of membrane tubulation
0.53	GO:0060997	dendritic spine morphogenesis
0.53	GO:0002685	regulation of leukocyte migration
0.52	GO:0032488	Cdc42 protein signal transduction
0.51	GO:0051653	spindle localization
0.51	GO:0002625	regulation of T cell antigen processing and presentation
0.51	GO:0034629	cellular protein complex localization

0.74	GO:0003779	actin binding
0.51	GO:0043274	phospholipase binding
0.49	GO:0048365	Rac GTPase binding
0.47	GO:0017124	SH3 domain binding
0.46	GO:0019901	protein kinase binding
0.45	GO:0042802	identical protein binding
0.34	GO:0030695	GTPase regulator activity
0.33	GO:0008168	methyltransferase activity

0.54	GO:0030478	actin cap
0.50	GO:0030027	lamellipodium
0.50	GO:0005829	cytosol
0.48	GO:0005884	actin filament
0.47	GO:0045335	phagocytic vesicle
0.45	GO:0012506	vesicle membrane
0.44	GO:0005911	cell-cell junction
0.41	GO:0070062	extracellular exosome
0.35	GO:0005634	nucleus
0.34	GO:0098588	bounding membrane of organelle

0.33

GO:0008168

sp|P42771|CDN2A_HUMAN
Cyclin-dependent kinase inhibitor 2A
Search

0.97	Cyclin dependant kinase inhibitor

0.65	GO:0007050	cell cycle arrest
0.63	GO:0044772	mitotic cell cycle phase transition
0.63	GO:0071901	negative regulation of protein serine/threonine kinase activity
0.62	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
0.62	GO:0008285	negative regulation of cell proliferation
0.60	GO:0030219	megakaryocyte differentiation
0.60	GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus
0.59	GO:0044839	cell cycle G2/M phase transition
0.58	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
0.58	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway

0.65	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
0.61	GO:0019901	protein kinase binding
0.53	GO:0016301	kinase activity
0.51	GO:0051059	NF-kappaB binding
0.39	GO:1990948	ubiquitin ligase inhibitor activity
0.39	GO:0097371	MDM2/MDM4 family protein binding
0.38	GO:0097718	disordered domain specific binding
0.38	GO:0047485	protein N-terminus binding
0.38	GO:0002039	p53 binding
0.38	GO:0019789	SUMO transferase activity

0.53	GO:0035985	senescence-associated heterochromatin focus
0.50	GO:0005634	nucleus
0.42	GO:0005737	cytoplasm
0.35	GO:0070013	intracellular organelle lumen
0.34	GO:0043234	protein complex
0.33	GO:0000151	ubiquitin ligase complex

sp|P42772|CDN2B_HUMAN
Cyclin-dependent kinase 4 inhibitor B
Search

0.97	Cyclin dependant kinase inhibitor

0.68	GO:0007050	cell cycle arrest
0.66	GO:0044772	mitotic cell cycle phase transition
0.66	GO:0071901	negative regulation of protein serine/threonine kinase activity
0.65	GO:0030219	megakaryocyte differentiation
0.65	GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus
0.65	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
0.65	GO:0008285	negative regulation of cell proliferation
0.63	GO:0044839	cell cycle G2/M phase transition
0.62	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
0.62	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway

0.68	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
0.63	GO:0019901	protein kinase binding
0.53	GO:0016301	kinase activity
0.51	GO:0051059	NF-kappaB binding
0.39	GO:1990948	ubiquitin ligase inhibitor activity
0.39	GO:0097371	MDM2/MDM4 family protein binding
0.38	GO:0097718	disordered domain specific binding
0.38	GO:0047485	protein N-terminus binding
0.38	GO:0002039	p53 binding
0.38	GO:0019789	SUMO transferase activity

0.53	GO:0035985	senescence-associated heterochromatin focus
0.52	GO:0005634	nucleus
0.43	GO:0005737	cytoplasm
0.36	GO:0070013	intracellular organelle lumen
0.34	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0004222

sp|P42773|CDN2C_HUMAN
Cyclin-dependent kinase 4 inhibitor C
Search

CDKN2C

0.97	Cyclin-dependent kinase 4 inhibitor C

0.66	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
0.63	GO:0030308	negative regulation of cell growth
0.62	GO:0007050	cell cycle arrest
0.62	GO:0000082	G1/S transition of mitotic cell cycle
0.60	GO:0008285	negative regulation of cell proliferation
0.52	GO:0016310	phosphorylation
0.42	GO:0048709	oligodendrocyte differentiation
0.37	GO:2000045	regulation of G1/S transition of mitotic cell cycle
0.36	GO:0007165	signal transduction
0.36	GO:0006915	apoptotic process

0.64	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
0.60	GO:0019901	protein kinase binding
0.54	GO:0016301	kinase activity
0.35	GO:0005216	ion channel activity
0.35	GO:0005096	GTPase activator activity
0.35	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.34	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.34	GO:0070273	phosphatidylinositol-4-phosphate binding
0.34	GO:0017137	Rab GTPase binding
0.34	GO:0016773	phosphotransferase activity, alcohol group as acceptor

0.49	GO:0005634	nucleus
0.42	GO:0005737	cytoplasm
0.35	GO:0098592	cytoplasmic side of apical plasma membrane
0.34	GO:0016323	basolateral plasma membrane
0.33	GO:0097708	intracellular vesicle
0.33	GO:0098805	whole membrane
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0012505	endomembrane system
0.33	GO:0032421	stereocilium bundle
0.32	GO:0044446	intracellular organelle part

0.34

GO:0016773

sp|P42785|PCP_HUMAN
Lysosomal Pro-X carboxypeptidase
Search

PRCP

0.87	Lysosomal Pro-X carboxypeptidase

0.61	GO:0006508	proteolysis
0.58	GO:0003085	negative regulation of systemic arterial blood pressure
0.57	GO:0060055	angiogenesis involved in wound healing
0.56	GO:0043535	regulation of blood vessel endothelial cell migration
0.55	GO:0002353	plasma kallikrein-kinin cascade
0.55	GO:0002155	regulation of thyroid hormone mediated signaling pathway
0.53	GO:0097009	energy homeostasis
0.51	GO:2000377	regulation of reactive oxygen species metabolic process
0.50	GO:0042593	glucose homeostasis
0.38	GO:0055114	oxidation-reduction process

0.67	GO:0017171	serine hydrolase activity
0.62	GO:0070011	peptidase activity, acting on L-amino acid peptides
0.42	GO:0005506	iron ion binding
0.39	GO:0016491	oxidoreductase activity
0.33	GO:0005515	protein binding
0.33	GO:0004013	adenosylhomocysteinase activity

0.52	GO:0045178	basal part of cell
0.39	GO:0005764	lysosome
0.37	GO:0070062	extracellular exosome
0.36	GO:0101003	ficolin-1-rich granule membrane
0.35	GO:0098852	lytic vacuole membrane
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.39

GO:0016491

sp|P42830|CXCL5_HUMAN
C-X-C motif chemokine 5
Search

0.83	Alveolar macrophage chemotactic factor

0.82	GO:0060326	cell chemotaxis
0.74	GO:0006955	immune response
0.72	GO:0006952	defense response
0.72	GO:0010469	regulation of receptor activity
0.56	GO:0032496	response to lipopolysaccharide
0.55	GO:0090023	positive regulation of neutrophil chemotaxis
0.53	GO:0002446	neutrophil mediated immunity
0.52	GO:0070098	chemokine-mediated signaling pathway
0.51	GO:1990266	neutrophil migration
0.51	GO:0042119	neutrophil activation

0.84	GO:0008009	chemokine activity
0.55	GO:0045236	CXCR chemokine receptor binding
0.43	GO:0042802	identical protein binding
0.41	GO:0008201	heparin binding

0.70	GO:0005615	extracellular space
0.30	GO:0016020	membrane
0.30	GO:0005623	cell

sp|P42857|NSG1_HUMAN
Neuron-specific protein family member 1
Search

HGNC:18790

0.97	Euron specific protein family member 1 variant 3

0.82	GO:0007212	dopamine receptor signaling pathway
0.80	GO:0048268	clathrin coat assembly
0.58	GO:0099627	neurotransmitter receptor cycle
0.57	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane
0.55	GO:0042982	amyloid precursor protein metabolic process
0.55	GO:0001881	receptor recycling
0.50	GO:0006915	apoptotic process
0.30	GO:0023056	positive regulation of signaling
0.30	GO:0099537	trans-synaptic signaling
0.30	GO:0010646	regulation of cell communication

0.82	GO:0032051	clathrin light chain binding
0.30	GO:0005102	receptor binding

0.54	GO:0016328	lateral plasma membrane
0.52	GO:0005770	late endosome
0.51	GO:0045211	postsynaptic membrane
0.47	GO:0005783	endoplasmic reticulum
0.35	GO:1990674	Golgi cis cisterna membrane
0.34	GO:0010008	endosome membrane
0.34	GO:0030659	cytoplasmic vesicle membrane
0.30	GO:0042995	cell projection
0.30	GO:0098845	postsynaptic endosome
0.30	GO:0016021	integral component of membrane

sp|P42858|HD_HUMAN
Huntingtin
Search

HTT

0.90	Huntingtin

0.64	GO:1905335	regulation of aggrephagy
0.63	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
0.62	GO:0098596	imitative learning
0.62	GO:1904502	regulation of lipophagy
0.61	GO:0098598	learned vocalization behavior or vocal learning
0.61	GO:0031223	auditory behavior
0.61	GO:1903599	positive regulation of autophagy of mitochondrion
0.60	GO:0045724	positive regulation of cilium assembly
0.59	GO:0031648	protein destabilization
0.59	GO:0047496	vesicle transport along microtubule

0.61	GO:0034452	dynactin binding
0.61	GO:0005522	profilin binding
0.59	GO:0045505	dynein intermediate chain binding
0.58	GO:0002039	p53 binding
0.58	GO:0044325	ion channel binding
0.58	GO:0048487	beta-tubulin binding
0.55	GO:0019900	kinase binding
0.54	GO:0031072	heat shock protein binding
0.52	GO:0042802	identical protein binding
0.46	GO:0008134	transcription factor binding

0.61	GO:0005634	nucleus
0.58	GO:0016234	inclusion body
0.58	GO:0005776	autophagosome
0.57	GO:0005814	centriole
0.56	GO:0030425	dendrite
0.56	GO:0005770	late endosome
0.56	GO:0030424	axon
0.55	GO:0048471	perinuclear region of cytoplasm
0.54	GO:0030659	cytoplasmic vesicle membrane
0.51	GO:0005794	Golgi apparatus

sp|P42892|ECE1_HUMAN
Endothelin-converting enzyme 1
Search

ECE1

0.76	Endothelin converting enzyme

0.85	GO:0016486	peptide hormone processing
0.57	GO:0010814	substance P catabolic process
0.57	GO:0010816	calcitonin catabolic process
0.56	GO:0010815	bradykinin catabolic process
0.55	GO:0001921	positive regulation of receptor recycling
0.54	GO:0060037	pharyngeal system development
0.54	GO:0002002	regulation of angiotensin levels in blood
0.53	GO:0042733	embryonic digit morphogenesis
0.51	GO:0043583	ear development
0.50	GO:0007507	heart development

0.70	GO:0004222	metalloendopeptidase activity
0.49	GO:0042803	protein homodimerization activity
0.44	GO:0008270	zinc ion binding
0.35	GO:0017046	peptide hormone binding
0.34	GO:0000339	RNA cap binding
0.33	GO:0003743	translation initiation factor activity

0.56	GO:0033093	Weibel-Palade body
0.51	GO:0009897	external side of plasma membrane
0.50	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0005768	endosome
0.37	GO:0044433	cytoplasmic vesicle part
0.37	GO:0012506	vesicle membrane
0.36	GO:0005765	lysosomal membrane
0.36	GO:0070062	extracellular exosome
0.34	GO:0031300	intrinsic component of organelle membrane
0.34	GO:0005794	Golgi apparatus

0.70

GO:0004222

sp|P42898|MTHR_HUMAN
Methylenetetrahydrofolate reductase
Search

MTHFR

0.50	Methylenetetrahydrofolate reductase

0.74	GO:0035999	tetrahydrofolate interconversion
0.71	GO:0006555	methionine metabolic process
0.59	GO:0070829	heterochromatin maintenance
0.56	GO:0031060	regulation of histone methylation
0.55	GO:0050667	homocysteine metabolic process
0.52	GO:0055114	oxidation-reduction process
0.40	GO:0033274	response to vitamin B2
0.39	GO:0051593	response to folic acid
0.38	GO:0070555	response to interleukin-1
0.38	GO:0043200	response to amino acid

0.79	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity
0.51	GO:0032403	protein complex binding
0.51	GO:0072341	modified amino acid binding
0.47	GO:0050660	flavin adenine dinucleotide binding
0.36	GO:0050661	NADP binding

0.43	GO:0005829	cytosol
0.37	GO:0045202	synapse

0.79	EC:1.5.1.20	GO:0004489
0.79	KEGG:R01224 KEGG:R07168	GO:0004489

sp|P43003|EAA1_HUMAN
Excitatory amino acid transporter 1
Search

SLC1A3

0.45	Amino acid transporter

0.60	GO:0140016	D-aspartate import across plasma membrane
0.60	GO:0140009	L-aspartate import across plasma membrane
0.59	GO:0009449	gamma-aminobutyric acid biosynthetic process
0.59	GO:0098712	L-glutamate import across plasma membrane
0.58	GO:0031223	auditory behavior
0.56	GO:0021545	cranial nerve development
0.56	GO:0050885	neuromuscular process controlling balance
0.55	GO:0050806	positive regulation of synaptic transmission
0.54	GO:0007605	sensory perception of sound
0.52	GO:0048667	cell morphogenesis involved in neuron differentiation

0.72	GO:0015293	symporter activity
0.58	GO:0016595	glutamate binding
0.55	GO:0005313	L-glutamate transmembrane transporter activity
0.51	GO:0015081	sodium ion transmembrane transporter activity
0.48	GO:0022853	active ion transmembrane transporter activity
0.35	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.53	GO:0043025	neuronal cell body
0.52	GO:0043005	neuron projection
0.51	GO:0009986	cell surface
0.47	GO:0005887	integral component of plasma membrane
0.35	GO:0045111	intermediate filament cytoskeleton
0.35	GO:0016323	basolateral plasma membrane
0.34	GO:0098794	postsynapse
0.34	GO:0120038	plasma membrane bounded cell projection part
0.33	GO:0005794	Golgi apparatus
0.33	GO:0019866	organelle inner membrane

sp|P43004|EAA2_HUMAN
Excitatory amino acid transporter 2
Search

SLC1A2

0.45	Amino acid transporter

0.58	GO:0070777	D-aspartate transport
0.57	GO:0098712	L-glutamate import across plasma membrane
0.55	GO:0070207	protein homotrimerization
0.55	GO:0046326	positive regulation of glucose import
0.55	GO:0007632	visual behavior
0.54	GO:0035264	multicellular organism growth
0.54	GO:0010259	multicellular organism aging
0.54	GO:0043200	response to amino acid
0.53	GO:0021537	telencephalon development
0.53	GO:0030534	adult behavior

0.72	GO:0015293	symporter activity
0.53	GO:0005313	L-glutamate transmembrane transporter activity
0.49	GO:0015081	sodium ion transmembrane transporter activity
0.47	GO:0022853	active ion transmembrane transporter activity
0.34	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.55	GO:0030673	axolemma
0.50	GO:0009986	cell surface
0.46	GO:0005887	integral component of plasma membrane
0.35	GO:0043198	dendritic shaft
0.35	GO:0042734	presynaptic membrane
0.35	GO:0043197	dendritic spine

sp|P43005|EAA3_HUMAN
Excitatory amino acid transporter 3
Search

SLC1A1

0.45	Amino acid transporter

0.60	GO:1903712	cysteine transmembrane transport
0.60	GO:0140016	D-aspartate import across plasma membrane
0.60	GO:0140009	L-aspartate import across plasma membrane
0.59	GO:0098712	L-glutamate import across plasma membrane
0.58	GO:0010460	positive regulation of heart rate
0.52	GO:0051260	protein homooligomerization
0.52	GO:1902476	chloride transmembrane transport
0.36	GO:0014047	glutamate secretion
0.35	GO:0007268	chemical synaptic transmission

0.72	GO:0015293	symporter activity
0.60	GO:0033229	cysteine transmembrane transporter activity
0.55	GO:0005313	L-glutamate transmembrane transporter activity
0.52	GO:0015108	chloride transmembrane transporter activity
0.51	GO:0015081	sodium ion transmembrane transporter activity
0.48	GO:0022853	active ion transmembrane transporter activity
0.38	GO:0016595	glutamate binding
0.35	GO:0005515	protein binding
0.33	GO:0046872	metal ion binding

0.54	GO:0016324	apical plasma membrane
0.47	GO:0005887	integral component of plasma membrane
0.37	GO:0070062	extracellular exosome

sp|P43007|SATT_HUMAN
Neutral amino acid transporter A
Search

SLC1A4

0.45	Neutral amino acid transporter A

0.61	GO:0034589	hydroxyproline transport
0.59	GO:0015811	L-cystine transport
0.59	GO:0015808	L-alanine transport
0.58	GO:0015825	L-serine transport
0.55	GO:0015826	threonine transport
0.55	GO:0055085	transmembrane transport
0.55	GO:0050890	cognition
0.54	GO:0015824	proline transport
0.52	GO:0006821	chloride transport
0.37	GO:0006868	glutamine transport

0.72	GO:0015293	symporter activity
0.61	GO:0034590	L-hydroxyproline transmembrane transporter activity
0.59	GO:0015184	L-cystine transmembrane transporter activity
0.59	GO:0015180	L-alanine transmembrane transporter activity
0.59	GO:0015194	L-serine transmembrane transporter activity
0.58	GO:0015195	L-threonine transmembrane transporter activity
0.55	GO:0015193	L-proline transmembrane transporter activity
0.52	GO:0005254	chloride channel activity
0.37	GO:0015186	L-glutamine transmembrane transporter activity
0.34	GO:0104005	hijacked molecular function

0.53	GO:0005882	intermediate filament
0.53	GO:0005813	centrosome
0.40	GO:0042470	melanosome
0.39	GO:0043025	neuronal cell body
0.39	GO:0030425	dendrite
0.37	GO:0070062	extracellular exosome
0.36	GO:0009986	cell surface
0.35	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P43026|GDF5_HUMAN
Growth/differentiation factor 5
Search

GDF5

0.97	Growth differentiation factor 5 preproprotein (Predicted)

0.74	GO:0010469	regulation of receptor activity
0.66	GO:0007184	SMAD protein import into nucleus
0.66	GO:0060591	chondroblast differentiation
0.66	GO:0032332	positive regulation of chondrocyte differentiation
0.66	GO:2001054	negative regulation of mesenchymal cell apoptotic process
0.64	GO:0032331	negative regulation of chondrocyte differentiation
0.64	GO:0060395	SMAD protein signal transduction
0.64	GO:0035137	hindlimb morphogenesis
0.64	GO:0035136	forelimb morphogenesis
0.63	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

0.77	GO:0008083	growth factor activity
0.65	GO:0036122	BMP binding
0.56	GO:0042802	identical protein binding
0.50	GO:0005160	transforming growth factor beta receptor binding
0.48	GO:0005125	cytokine activity
0.35	GO:0046983	protein dimerization activity

0.65	GO:0005576	extracellular region
0.34	GO:0005886	plasma membrane
0.33	GO:0005750	mitochondrial respiratory chain complex III
0.30	GO:0016021	integral component of membrane

sp|P43034|LIS1_HUMAN
Platelet-activating factor acetylhydrolase IB subunit alpha
Search

PAFAH1B1

0.81	Platelet-activating factor acetylhydrolase IB subunit alpha

0.78	GO:0000132	establishment of mitotic spindle orientation
0.69	GO:0007399	nervous system development
0.67	GO:0051301	cell division
0.67	GO:0030154	cell differentiation
0.53	GO:0008090	retrograde axonal transport
0.51	GO:0090176	microtubule cytoskeleton organization involved in establishment of planar polarity
0.51	GO:0047496	vesicle transport along microtubule
0.51	GO:0051081	nuclear envelope disassembly
0.51	GO:0051661	maintenance of centrosome location
0.50	GO:0042249	establishment of planar polarity of embryonic epithelium

0.77	GO:0070840	dynein complex binding
0.48	GO:0051219	phosphoprotein binding
0.47	GO:0008017	microtubule binding
0.45	GO:0042803	protein homodimerization activity
0.41	GO:0016787	hydrolase activity
0.32	GO:0008168	methyltransferase activity
0.30	GO:0045505	dynein intermediate chain binding
0.30	GO:0019899	enzyme binding
0.30	GO:0043167	ion binding
0.30	GO:1901681	sulfur compound binding

0.73	GO:0005874	microtubule
0.70	GO:0005815	microtubule organizing center
0.70	GO:0005875	microtubule associated complex
0.51	GO:1904115	axon cytoplasm
0.49	GO:0005818	aster
0.49	GO:0032420	stereocilium
0.49	GO:0005635	nuclear envelope
0.48	GO:0000776	kinetochore
0.47	GO:0005938	cell cortex
0.47	GO:0031252	cell leading edge

0.41

GO:0016787

sp|P43080|GUC1A_HUMAN
Guanylyl cyclase-activating protein 1
Search

GUCA1A

0.97	Guanylate cyclase activating protein 1

0.83	GO:0031284	positive regulation of guanylate cyclase activity
0.71	GO:0007601	visual perception
0.53	GO:0007602	phototransduction
0.40	GO:0071277	cellular response to calcium ion
0.36	GO:0022400	regulation of rhodopsin mediated signaling pathway

0.84	GO:0008048	calcium sensitive guanylate cyclase activator activity
0.70	GO:0005509	calcium ion binding
0.33	GO:0005515	protein binding

0.73	GO:0001750	photoreceptor outer segment
0.40	GO:0001917	photoreceptor inner segment
0.35	GO:0060170	ciliary membrane

sp|P43088|PF2R_HUMAN
Prostaglandin F2-alpha receptor
Search

PTGFR

0.97	Ovarian prostaglandin F receptor

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.66	GO:0071798	response to prostaglandin D
0.63	GO:0071379	cellular response to prostaglandin stimulus
0.63	GO:0035584	calcium-mediated signaling using intracellular calcium source
0.62	GO:0032355	response to estradiol
0.59	GO:0032496	response to lipopolysaccharide
0.57	GO:0008284	positive regulation of cell proliferation
0.57	GO:0043066	negative regulation of apoptotic process
0.53	GO:0010628	positive regulation of gene expression
0.36	GO:0007567	parturition

0.86	GO:0004958	prostaglandin F receptor activity
0.48	GO:0004960	thromboxane receptor activity
0.46	GO:0004957	prostaglandin E receptor activity

0.50	GO:0005576	extracellular region
0.44	GO:0005886	plasma membrane
0.41	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|P43115|PE2R3_HUMAN
Prostaglandin E2 receptor EP3 subtype
Search

PTGER3

0.97	Prostaglandin E receptor 3

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.52	GO:0060455	negative regulation of gastric acid secretion
0.52	GO:0014827	intestine smooth muscle contraction
0.40	GO:0031622	positive regulation of fever generation
0.38	GO:0035810	positive regulation of urine volume
0.38	GO:0001660	fever generation
0.37	GO:0015701	bicarbonate transport
0.37	GO:0032496	response to lipopolysaccharide
0.37	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.37	GO:1990767	prostaglandin receptor internalization

0.85	GO:0004957	prostaglandin E receptor activity
0.46	GO:0004960	thromboxane receptor activity
0.35	GO:0005515	protein binding
0.33	GO:0004958	prostaglandin F receptor activity
0.32	GO:0046872	metal ion binding

0.36	GO:0005635	nuclear envelope
0.36	GO:0005886	plasma membrane
0.36	GO:1990769	proximal neuron projection
0.35	GO:0005903	brush border
0.35	GO:0043025	neuronal cell body
0.34	GO:0120038	plasma membrane bounded cell projection part
0.34	GO:0009986	cell surface
0.33	GO:0031090	organelle membrane
0.30	GO:0016021	integral component of membrane

sp|P43116|PE2R2_HUMAN
Prostaglandin E2 receptor EP2 subtype
Search

PTGER2

0.93	Prostacyclin receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.63	GO:0071379	cellular response to prostaglandin stimulus
0.63	GO:0034695	response to prostaglandin E
0.61	GO:1901655	cellular response to ketone
0.60	GO:0097306	cellular response to alcohol
0.57	GO:0019933	cAMP-mediated signaling
0.57	GO:0032570	response to progesterone
0.57	GO:0032496	response to lipopolysaccharide
0.53	GO:0042127	regulation of cell proliferation
0.43	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway

0.85	GO:0004955	prostaglandin receptor activity
0.43	GO:0004960	thromboxane receptor activity
0.32	GO:0005515	protein binding

0.41	GO:0005886	plasma membrane
0.38	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

sp|P43119|PI2R_HUMAN
Prostacyclin receptor
Search

PTGIR

0.95	Prostacyclin receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.60	GO:0032496	response to lipopolysaccharide
0.59	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
0.59	GO:0019933	cAMP-mediated signaling
0.58	GO:0048662	negative regulation of smooth muscle cell proliferation
0.46	GO:0071380	cellular response to prostaglandin E stimulus
0.44	GO:0032570	response to progesterone
0.44	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
0.43	GO:0045987	positive regulation of smooth muscle contraction
0.43	GO:0019229	regulation of vasoconstriction

0.72	GO:0004954	prostanoid receptor activity
0.35	GO:0005085	guanyl-nucleotide exchange factor activity

0.49	GO:0005829	cytosol
0.44	GO:0005886	plasma membrane
0.41	GO:0016607	nuclear speck
0.35	GO:0001669	acrosomal vesicle
0.30	GO:0016021	integral component of membrane

sp|P43121|MUC18_HUMAN
Cell surface glycoprotein MUC18
Search

MCAM

0.94	Melanoma cell adhesion molecule

0.67	GO:0061042	vascular wound healing
0.66	GO:0003094	glomerular filtration
0.43	GO:0030335	positive regulation of cell migration
0.39	GO:0007155	cell adhesion
0.38	GO:0031103	axon regeneration
0.38	GO:0060026	convergent extension
0.33	GO:1990399	epithelium regeneration
0.33	GO:0001946	lymphangiogenesis
0.33	GO:0098743	cell aggregation
0.33	GO:0010976	positive regulation of neuron projection development

0.33	GO:0098632	cell-cell adhesion mediator activity
0.33	GO:0050840	extracellular matrix binding
0.33	GO:0008233	peptidase activity
0.32	GO:0042802	identical protein binding
0.32	GO:0005509	calcium ion binding

0.60	GO:0009897	external side of plasma membrane
0.52	GO:0005576	extracellular region
0.39	GO:0005925	focal adhesion
0.38	GO:0005634	nucleus
0.37	GO:0043204	perikaryon
0.33	GO:0016323	basolateral plasma membrane
0.32	GO:0005788	endoplasmic reticulum lumen
0.30	GO:0016021	integral component of membrane

0.33

GO:0008233

sp|P43146|DCC_HUMAN
Netrin receptor DCC
Search

DCC

0.94	Netrin receptor DCC

0.85	GO:0038007	netrin-activated signaling pathway
0.81	GO:0007411	axon guidance
0.77	GO:0006915	apoptotic process
0.60	GO:0021965	spinal cord ventral commissure morphogenesis
0.56	GO:1901214	regulation of neuron death
0.55	GO:0001764	neuron migration
0.39	GO:0010975	regulation of neuron projection development
0.38	GO:2000171	negative regulation of dendrite development
0.38	GO:0001975	response to amphetamine
0.37	GO:0038034	signal transduction in absence of ligand

0.85	GO:0005042	netrin receptor activity
0.37	GO:0005515	protein binding
0.36	GO:0003713	transcription coactivator activity
0.30	GO:0003824	catalytic activity

0.53	GO:0030424	axon
0.38	GO:0032584	growth cone membrane
0.36	GO:0045121	membrane raft
0.35	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

sp|P43155|CACP_HUMAN
Carnitine O-acetyltransferase
Search

CRAT

0.80	Carnitine O-acetyltransferase

0.58	GO:0019254	carnitine metabolic process, CoA-linked
0.37	GO:0006631	fatty acid metabolic process
0.34	GO:0034440	lipid oxidation
0.34	GO:0044242	cellular lipid catabolic process
0.34	GO:0072329	monocarboxylic acid catabolic process

0.63	GO:0016746	transferase activity, transferring acyl groups
0.49	GO:0005102	receptor binding

0.51	GO:0005777	peroxisome
0.44	GO:0005739	mitochondrion
0.37	GO:0005783	endoplasmic reticulum
0.35	GO:0019866	organelle inner membrane
0.35	GO:0031907	microbody lumen
0.30	GO:0031224	intrinsic component of membrane

0.63

EC:2.3

GO:0016746

sp|P43166|CAH7_HUMAN
Carbonic anhydrase 7
Search

CA7

0.97	Carbonic anhydrase VII

0.72	GO:0006730	one-carbon metabolic process
0.60	GO:0032849	positive regulation of cellular pH reduction
0.58	GO:2001225	regulation of chloride transport
0.58	GO:0032230	positive regulation of synaptic transmission, GABAergic
0.36	GO:0015701	bicarbonate transport
0.36	GO:0015670	carbon dioxide transport
0.36	GO:0042539	hypotonic salinity response

0.77	GO:0004089	carbonate dehydratase activity
0.63	GO:0008270	zinc ion binding

0.48	GO:0005829	cytosol
0.43	GO:0005739	mitochondrion
0.33	GO:0043233	organelle lumen
0.32	GO:0005886	plasma membrane
0.32	GO:0044446	intracellular organelle part

0.77

EC:4.2.1.1

GO:0004089

sp|P43220|GLP1R_HUMAN
Glucagon-like peptide 1 receptor
Search

GLP1R

0.97	Glucagon like peptide 1 receptor

0.82	GO:0071377	cellular response to glucagon stimulus
0.70	GO:0007166	cell surface receptor signaling pathway
0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.60	GO:0019933	cAMP-mediated signaling
0.57	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.54	GO:0045777	positive regulation of blood pressure
0.52	GO:0008016	regulation of heart contraction
0.52	GO:0007611	learning or memory
0.46	GO:0010906	regulation of glucose metabolic process
0.44	GO:0006950	response to stress

0.83	GO:0004967	glucagon receptor activity
0.64	GO:0044508	glucagon-like peptide 1 receptor activity
0.57	GO:0016519	gastric inhibitory peptide receptor activity
0.45	GO:0017046	peptide hormone binding
0.34	GO:0003777	microtubule motor activity
0.34	GO:0005515	protein binding

0.52	GO:0005886	plasma membrane
0.39	GO:0005622	intracellular
0.33	GO:1902494	catalytic complex
0.33	GO:0043234	protein complex
0.33	GO:0043228	non-membrane-bounded organelle
0.33	GO:0044422	organelle part
0.30	GO:0016021	integral component of membrane

sp|P43234|CATO_HUMAN
Cathepsin O
Search

CTSO

0.93	Acid sensing ion channel subunit family member 5

0.61	GO:0006508	proteolysis
0.45	GO:0044257	cellular protein catabolic process
0.36	GO:0035725	sodium ion transmembrane transport

0.72	GO:0008234	cysteine-type peptidase activity
0.42	GO:0004175	endopeptidase activity
0.36	GO:0005272	sodium channel activity
0.32	GO:0005515	protein binding

0.47	GO:0005764	lysosome
0.45	GO:0005615	extracellular space
0.30	GO:0031224	intrinsic component of membrane

0.72

GO:0008234

sp|P43235|CATK_HUMAN
Cathepsin K
Search

CTSK

0.93	Cathepsin K (Pycnodysostosis)

0.61	GO:0006508	proteolysis
0.59	GO:0030574	collagen catabolic process
0.58	GO:1903146	regulation of autophagy of mitochondrion
0.57	GO:1903955	positive regulation of protein targeting to mitochondrion
0.54	GO:0044257	cellular protein catabolic process
0.43	GO:0060348	bone development
0.43	GO:0009612	response to mechanical stimulus
0.43	GO:0051216	cartilage development
0.41	GO:0001957	intramembranous ossification
0.40	GO:0022617	extracellular matrix disassembly

0.72	GO:0008234	cysteine-type peptidase activity
0.60	GO:0001968	fibronectin binding
0.59	GO:0043394	proteoglycan binding
0.57	GO:0005518	collagen binding
0.50	GO:0004175	endopeptidase activity
0.37	GO:0046983	protein dimerization activity
0.37	GO:0043236	laminin binding
0.36	GO:0003700	DNA binding transcription factor activity
0.35	GO:0003677	DNA binding
0.34	GO:0070273	phosphatidylinositol-4-phosphate binding

0.55	GO:0005615	extracellular space
0.50	GO:0005764	lysosome
0.49	GO:0005654	nucleoplasm
0.39	GO:0005667	transcription factor complex
0.36	GO:0031904	endosome lumen
0.35	GO:0005775	vacuolar lumen
0.30	GO:0016020	membrane

0.72

GO:0008234

sp|P43243|MATR3_HUMAN
Matrin-3
Search

MATR3

0.91	Nuclear protein matrin 3

0.44	GO:0003170	heart valve development
0.44	GO:0003281	ventricular septum development
0.38	GO:0002218	activation of innate immune response
0.38	GO:0045087	innate immune response
0.37	GO:0010608	posttranscriptional regulation of gene expression

0.63	GO:0008270	zinc ion binding
0.59	GO:0003723	RNA binding
0.37	GO:0042802	identical protein binding
0.33	GO:0005198	structural molecule activity

0.58	GO:0005634	nucleus
0.36	GO:0031974	membrane-enclosed lumen
0.35	GO:0044446	intracellular organelle part
0.34	GO:0012505	endomembrane system
0.33	GO:0031090	organelle membrane
0.33	GO:0031975	envelope
0.32	GO:0005737	cytoplasm

sp|P43246|MSH2_HUMAN
DNA mismatch repair protein Msh2
Search

MSH2

0.64	LOW QUALITY PROTEIN: DNA mismatch repair protein Msh2

0.72	GO:0006298	mismatch repair
0.59	GO:0016446	somatic hypermutation of immunoglobulin genes
0.59	GO:0002204	somatic recombination of immunoglobulin genes involved in immune response
0.59	GO:0051096	positive regulation of helicase activity
0.58	GO:0010165	response to X-ray
0.58	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.58	GO:0048298	positive regulation of isotype switching to IgA isotypes
0.58	GO:0002312	B cell activation involved in immune response
0.57	GO:0048304	positive regulation of isotype switching to IgG isotypes
0.57	GO:0010224	response to UV-B

0.73	GO:0030983	mismatched DNA binding
0.59	GO:0032405	MutLalpha complex binding
0.59	GO:0032357	oxidized purine DNA binding
0.58	GO:0000400	four-way junction DNA binding
0.56	GO:0019237	centromeric DNA binding
0.55	GO:0008022	protein C-terminus binding
0.53	GO:0030554	adenyl nucleotide binding
0.52	GO:0019901	protein kinase binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0032555	purine ribonucleotide binding

0.81	GO:0032301	MutSalpha complex
0.60	GO:0032302	MutSbeta complex
0.37	GO:0000784	nuclear chromosome, telomeric region
0.34	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.45

GO:0016887

sp|P43250|GRK6_HUMAN
G protein-coupled receptor kinase 6
Search

GRK6

0.69	G protein-coupled receptor kinase

0.63	GO:0006468	protein phosphorylation
0.60	GO:0007165	signal transduction
0.37	GO:0198738	cell-cell signaling by wnt
0.36	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.35	GO:0010360	negative regulation of anion channel activity
0.35	GO:0022401	negative adaptation of signaling pathway
0.34	GO:0035469	determination of pancreatic left/right asymmetry
0.34	GO:1902017	regulation of cilium assembly
0.34	GO:0001947	heart looping
0.34	GO:0032007	negative regulation of TOR signaling

0.85	GO:0004703	G-protein coupled receptor kinase activity
0.57	GO:0047696	beta-adrenergic receptor kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding

0.34	GO:0005886	plasma membrane
0.33	GO:0005829	cytosol

0.85

EC:2.7.11.16

GO:0004703

sp|P43251|BTD_HUMAN
Biotinidase
Search

BTD

0.97	Biotinidase

0.48	GO:0007417	central nervous system development
0.48	GO:0006768	biotin metabolic process
0.34	GO:0015939	pantothenate metabolic process

0.68

GO:0016811

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

0.40	GO:0005615	extracellular space
0.38	GO:0043204	perikaryon
0.38	GO:1903561	extracellular vesicle
0.37	GO:0045177	apical part of cell
0.37	GO:0070013	intracellular organelle lumen
0.35	GO:0044428	nuclear part
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.34	GO:0044429	mitochondrial part
0.30	GO:0016020	membrane

0.68

EC:3.5.1

GO:0016811

sp|P43268|ETV4_HUMAN
ETS translocation variant 4
Search

ETV4

0.97	ETS translocation variant 4

0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:0051254	positive regulation of RNA metabolic process
0.53	GO:0010557	positive regulation of macromolecule biosynthetic process
0.53	GO:0031328	positive regulation of cellular biosynthetic process
0.53	GO:0048935	peripheral nervous system neuron development
0.48	GO:0006366	transcription by RNA polymerase II
0.42	GO:0007411	axon guidance
0.41	GO:0048513	animal organ development

0.64	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.56	GO:0001012	RNA polymerase II regulatory region DNA binding
0.53	GO:0003690	double-stranded DNA binding
0.34	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.48	GO:0031974	membrane-enclosed lumen
0.45	GO:0043232	intracellular non-membrane-bounded organelle
0.44	GO:0044446	intracellular organelle part

sp|P43304|GPDM_HUMAN
Glycerol-3-phosphate dehydrogenase, mitochondrial
Search

GPD2

0.51	Glycerol-3-phosphate dehydrogenase, mitochondrial

0.76	GO:0006072	glycerol-3-phosphate metabolic process
0.53	GO:0035264	multicellular organism growth
0.53	GO:0055114	oxidation-reduction process
0.52	GO:0043010	camera-type eye development
0.48	GO:0019319	hexose biosynthetic process
0.48	GO:0006006	glucose metabolic process
0.40	GO:0019563	glycerol catabolic process
0.37	GO:0006734	NADH metabolic process
0.34	GO:0042180	cellular ketone metabolic process
0.33	GO:0006091	generation of precursor metabolites and energy

0.79	GO:0004368	glycerol-3-phosphate dehydrogenase activity
0.68	GO:0005509	calcium ion binding
0.34	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity
0.33	GO:0043565	sequence-specific DNA binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0003700	DNA binding transcription factor activity

0.76	GO:0009331	glycerol-3-phosphate dehydrogenase complex
0.44	GO:0031966	mitochondrial membrane
0.44	GO:0019866	organelle inner membrane
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.79	EC:1.1.5.3	GO:0004368
0.34	KEGG:R00842	GO:0004367

sp|P43307|SSRA_HUMAN
Translocon-associated protein subunit alpha
Search

SSR1

0.83	Translocon-associated protein subunit alpha

0.44	GO:0006613	cotranslational protein targeting to membrane
0.43	GO:0071391	cellular response to estrogen stimulus
0.35	GO:0036498	IRE1-mediated unfolded protein response
0.34	GO:0008284	positive regulation of cell proliferation

0.33

GO:0005515

protein binding

0.72	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P43308|SSRB_HUMAN
Translocon-associated protein subunit beta
Search

SSR2

0.88	Translocon-associated protein subunit beta

0.44

GO:0006613

cotranslational protein targeting to membrane

0.38

GO:0051087

chaperone binding

0.65	GO:0005783	endoplasmic reticulum
0.62	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.59	GO:0031984	organelle subcompartment
0.30	GO:0044425	membrane part

sp|P43320|CRBB2_HUMAN
Beta-crystallin B2
Search

CRYBB2

0.97	Beta B2-crystallin short isoform

0.73	GO:0007601	visual perception
0.53	GO:0043010	camera-type eye development
0.34	GO:0006468	protein phosphorylation
0.34	GO:0050896	response to stimulus
0.33	GO:0023052	signaling
0.33	GO:0007154	cell communication
0.33	GO:0050789	regulation of biological process

0.80	GO:0005212	structural constituent of eye lens
0.51	GO:0042803	protein homodimerization activity
0.38	GO:0047696	beta-adrenergic receptor kinase activity
0.36	GO:0004703	G-protein coupled receptor kinase activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.38

EC:2.7.11.15

GO:0047696

sp|P43351|RAD52_HUMAN
DNA repair protein RAD52 homolog
Search

RAD52

0.95	DNA repair protein RAD52 homolog

0.84	GO:0045002	double-strand break repair via single-strand annealing
0.84	GO:0000730	DNA recombinase assembly
0.58	GO:2000819	regulation of nucleotide-excision repair
0.58	GO:0000729	DNA double-strand break processing
0.53	GO:0051260	protein homooligomerization
0.52	GO:0034599	cellular response to oxidative stress
0.34	GO:0007015	actin filament organization

0.51	GO:0042802	identical protein binding
0.51	GO:0003697	single-stranded DNA binding
0.35	GO:0003785	actin monomer binding
0.33	GO:0005509	calcium ion binding

0.60	GO:0005634	nucleus
0.50	GO:0032993	protein-DNA complex
0.44	GO:0043234	protein complex
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part

sp|P43353|AL3B1_HUMAN
Aldehyde dehydrogenase family 3 member B1
Search

ALDH3B1

0.42	Aldehyde dehydrogenase

0.65	GO:0006081	cellular aldehyde metabolic process
0.52	GO:0055114	oxidation-reduction process
0.48	GO:0034599	cellular response to oxidative stress
0.44	GO:0044248	cellular catabolic process
0.43	GO:1901575	organic substance catabolic process
0.41	GO:0006067	ethanol metabolic process
0.38	GO:0044282	small molecule catabolic process
0.37	GO:0030148	sphingolipid biosynthetic process
0.36	GO:0043312	neutrophil degranulation

0.74	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
0.50	GO:0004029	aldehyde dehydrogenase (NAD) activity
0.39	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity
0.34	GO:0008106	alcohol dehydrogenase (NADP+) activity
0.34	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
0.33	GO:0005515	protein binding
0.33	GO:0016788	hydrolase activity, acting on ester bonds

0.45	GO:0005829	cytosol
0.40	GO:0005886	plasma membrane
0.37	GO:0070062	extracellular exosome
0.36	GO:0005811	lipid droplet
0.36	GO:0035579	specific granule membrane
0.33	GO:0005783	endoplasmic reticulum
0.30	GO:0031224	intrinsic component of membrane

0.74

EC:1.2.1.5

GO:0004030

sp|P43354|NR4A2_HUMAN
Nuclear receptor subfamily 4 group A member 2
Search

NR4A2

0.97	Nuclear receptor subfamily 4 group A member 2 variant TINUR

0.79	GO:0030522	intracellular receptor signaling pathway
0.76	GO:0043401	steroid hormone mediated signaling pathway
0.61	GO:0051866	general adaptation syndrome
0.61	GO:0071376	cellular response to corticotropin-releasing hormone stimulus
0.59	GO:0071542	dopaminergic neuron differentiation
0.59	GO:0021986	habenula development
0.59	GO:0042416	dopamine biosynthetic process
0.58	GO:0042053	regulation of dopamine metabolic process
0.58	GO:0001975	response to amphetamine
0.58	GO:0043576	regulation of respiratory gaseous exchange

0.81	GO:0004879	nuclear receptor activity
0.77	GO:0003707	steroid hormone receptor activity
0.62	GO:0043565	sequence-specific DNA binding
0.61	GO:0008270	zinc ion binding
0.59	GO:0035259	glucocorticoid receptor binding
0.55	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.53	GO:0001012	RNA polymerase II regulatory region DNA binding
0.51	GO:0046982	protein heterodimerization activity
0.50	GO:0003690	double-stranded DNA binding
0.36	GO:0046965	retinoid X receptor binding

0.61	GO:0005634	nucleus
0.49	GO:0070013	intracellular organelle lumen
0.44	GO:0044446	intracellular organelle part
0.35	GO:0005737	cytoplasm
0.33	GO:0005667	transcription factor complex

sp|P43355|MAGA1_HUMAN
Melanoma-associated antigen 1
Search

0.91	Putative MAGE domain-containing protein MAGEA13P

0.72	GO:0000122	negative regulation of transcription by RNA polymerase II
0.65	GO:0045746	negative regulation of Notch signaling pathway

0.78

GO:0042826

histone deacetylase binding

0.55	GO:0005634	nucleus
0.49	GO:0005829	cytosol
0.49	GO:0043233	organelle lumen
0.44	GO:0044446	intracellular organelle part

sp|P43356|MAGA2_HUMAN
Melanoma-associated antigen 2
Search

0.97	Tumor antigen MAGE-N

0.58	GO:0000122	negative regulation of transcription by RNA polymerase II
0.51	GO:0045746	negative regulation of Notch signaling pathway
0.43	GO:0033234	negative regulation of protein sumoylation
0.43	GO:0090398	cellular senescence
0.42	GO:1901984	negative regulation of protein acetylation
0.42	GO:0072331	signal transduction by p53 class mediator
0.42	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.41	GO:0051443	positive regulation of ubiquitin-protein transferase activity
0.41	GO:0010955	negative regulation of protein processing
0.41	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

0.62	GO:0042826	histone deacetylase binding
0.42	GO:0089720	caspase binding
0.42	GO:0070491	repressing transcription factor binding
0.41	GO:0031625	ubiquitin protein ligase binding

0.54	GO:0016604	nuclear body
0.51	GO:0005829	cytosol
0.38	GO:0005783	endoplasmic reticulum
0.35	GO:0005886	plasma membrane

sp|P43357|MAGA3_HUMAN
Melanoma-associated antigen 3
Search

0.97	Tumor antigen MAGE-N

0.58	GO:0000122	negative regulation of transcription by RNA polymerase II
0.51	GO:0045746	negative regulation of Notch signaling pathway
0.43	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.42	GO:0010955	negative regulation of protein processing
0.42	GO:0033234	negative regulation of protein sumoylation
0.42	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.42	GO:0090398	cellular senescence
0.41	GO:1901984	negative regulation of protein acetylation
0.41	GO:0072331	signal transduction by p53 class mediator
0.40	GO:0051443	positive regulation of ubiquitin-protein transferase activity

0.62	GO:0042826	histone deacetylase binding
0.43	GO:0089720	caspase binding
0.41	GO:0070491	repressing transcription factor binding
0.40	GO:0031625	ubiquitin protein ligase binding

0.54	GO:0016604	nuclear body
0.52	GO:0005829	cytosol
0.39	GO:0005783	endoplasmic reticulum
0.35	GO:0005886	plasma membrane

sp|P43358|MAGA4_HUMAN
Melanoma-associated antigen 4
Search

0.97	Tumor antigen MAGE-N

0.59	GO:0000122	negative regulation of transcription by RNA polymerase II
0.52	GO:0045746	negative regulation of Notch signaling pathway
0.40	GO:0033234	negative regulation of protein sumoylation
0.40	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.40	GO:0090398	cellular senescence
0.40	GO:1901984	negative regulation of protein acetylation
0.40	GO:0010955	negative regulation of protein processing
0.40	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.40	GO:0072331	signal transduction by p53 class mediator
0.39	GO:0051443	positive regulation of ubiquitin-protein transferase activity

0.63	GO:0042826	histone deacetylase binding
0.41	GO:0089720	caspase binding
0.40	GO:0070491	repressing transcription factor binding
0.39	GO:0031625	ubiquitin protein ligase binding

0.54	GO:0016604	nuclear body
0.52	GO:0005829	cytosol
0.37	GO:0005783	endoplasmic reticulum
0.35	GO:0005886	plasma membrane

sp|P43359|MAGA5_HUMAN
Melanoma-associated antigen 5
Search

0.97	Melanoma-associated antigen 5

0.51	GO:0051172	negative regulation of nitrogen compound metabolic process
0.51	GO:0031324	negative regulation of cellular metabolic process
0.51	GO:0010629	negative regulation of gene expression
0.50	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.49	GO:0051983	regulation of chromosome segregation
0.49	GO:0033233	regulation of protein sumoylation
0.49	GO:0090398	cellular senescence
0.48	GO:0070613	regulation of protein processing
0.48	GO:0010558	negative regulation of macromolecule biosynthetic process
0.48	GO:0006357	regulation of transcription by RNA polymerase II

0.59

GO:0005515

protein binding

0.55	GO:0016604	nuclear body
0.46	GO:0005829	cytosol
0.43	GO:0005783	endoplasmic reticulum
0.38	GO:0005886	plasma membrane

sp|P43360|MAGA6_HUMAN
Melanoma-associated antigen 6
Search

0.97	Tumor antigen MAGE-N

0.58	GO:0000122	negative regulation of transcription by RNA polymerase II
0.51	GO:0045746	negative regulation of Notch signaling pathway
0.43	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.42	GO:0010955	negative regulation of protein processing
0.42	GO:0033234	negative regulation of protein sumoylation
0.42	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.41	GO:0090398	cellular senescence
0.41	GO:1901984	negative regulation of protein acetylation
0.41	GO:0072331	signal transduction by p53 class mediator
0.40	GO:0051443	positive regulation of ubiquitin-protein transferase activity

0.62	GO:0042826	histone deacetylase binding
0.43	GO:0089720	caspase binding
0.41	GO:0070491	repressing transcription factor binding
0.40	GO:0031625	ubiquitin protein ligase binding

0.54	GO:0016604	nuclear body
0.52	GO:0005829	cytosol
0.39	GO:0005783	endoplasmic reticulum
0.35	GO:0005886	plasma membrane

sp|P43361|MAGA8_HUMAN
Melanoma-associated antigen 8
Search

0.97	Tumor antigen MAGE-N

0.58	GO:0000122	negative regulation of transcription by RNA polymerase II
0.52	GO:0045746	negative regulation of Notch signaling pathway
0.41	GO:0033234	negative regulation of protein sumoylation
0.40	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.40	GO:0090398	cellular senescence
0.40	GO:1901984	negative regulation of protein acetylation
0.40	GO:0010955	negative regulation of protein processing
0.40	GO:0072331	signal transduction by p53 class mediator
0.40	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.39	GO:0051443	positive regulation of ubiquitin-protein transferase activity

0.63	GO:0042826	histone deacetylase binding
0.41	GO:0089720	caspase binding
0.40	GO:0070491	repressing transcription factor binding
0.39	GO:0031625	ubiquitin protein ligase binding

0.56	GO:0005654	nucleoplasm
0.54	GO:0005829	cytosol
0.37	GO:0005783	endoplasmic reticulum
0.35	GO:0005886	plasma membrane

sp|P43362|MAGA9_HUMAN
Melanoma-associated antigen 9
Search

0.97	Tumor antigen MAGE-N

0.56	GO:0000122	negative regulation of transcription by RNA polymerase II
0.50	GO:0045746	negative regulation of Notch signaling pathway
0.40	GO:0033234	negative regulation of protein sumoylation
0.40	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.40	GO:0090398	cellular senescence
0.39	GO:1901984	negative regulation of protein acetylation
0.39	GO:0010955	negative regulation of protein processing
0.39	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.39	GO:0072331	signal transduction by p53 class mediator
0.39	GO:0051443	positive regulation of ubiquitin-protein transferase activity

0.60	GO:0042826	histone deacetylase binding
0.40	GO:0089720	caspase binding
0.39	GO:0070491	repressing transcription factor binding
0.38	GO:0031625	ubiquitin protein ligase binding

0.54	GO:0005654	nucleoplasm
0.52	GO:0005829	cytosol
0.37	GO:0005783	endoplasmic reticulum
0.34	GO:0005886	plasma membrane

sp|P43363|MAGAA_HUMAN
Melanoma-associated antigen 10
Search

0.91	Melanoma-associated antigen 8

0.53	GO:0000122	negative regulation of transcription by RNA polymerase II
0.49	GO:0045746	negative regulation of Notch signaling pathway
0.35	GO:0006351	transcription, DNA-templated

0.56

GO:0042826

histone deacetylase binding

0.61	GO:0005654	nucleoplasm
0.59	GO:0005829	cytosol
0.34	GO:0005886	plasma membrane

sp|P43364|MAGAB_HUMAN
Melanoma-associated antigen 11
Search

0.89	Putative MAGE domain-containing protein MAGEA13P

0.36

GO:0005515

protein binding

0.67	GO:0016604	nuclear body
0.64	GO:0005829	cytosol

sp|P43365|MAGAC_HUMAN
Melanoma-associated antigen 12
Search

0.97	Tumor antigen MAGE-N

0.58	GO:0000122	negative regulation of transcription by RNA polymerase II
0.51	GO:0045746	negative regulation of Notch signaling pathway
0.42	GO:0033234	negative regulation of protein sumoylation
0.42	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.42	GO:0090398	cellular senescence
0.42	GO:1901984	negative regulation of protein acetylation
0.41	GO:0010955	negative regulation of protein processing
0.41	GO:0072331	signal transduction by p53 class mediator
0.41	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.41	GO:0051443	positive regulation of ubiquitin-protein transferase activity

0.62	GO:0042826	histone deacetylase binding
0.42	GO:0089720	caspase binding
0.41	GO:0070491	repressing transcription factor binding
0.40	GO:0031625	ubiquitin protein ligase binding

0.54	GO:0016604	nuclear body
0.52	GO:0005829	cytosol
0.38	GO:0005783	endoplasmic reticulum
0.35	GO:0005886	plasma membrane

sp|P43366|MAGB1_HUMAN
Melanoma-associated antigen B1
Search

0.96	Melanoma-associated antigen B1

0.42	GO:0051443	positive regulation of ubiquitin-protein transferase activity
0.41	GO:0007186	G-protein coupled receptor signaling pathway
0.39	GO:0044257	cellular protein catabolic process

0.48	GO:0005515	protein binding
0.43	GO:0008528	G-protein coupled peptide receptor activity

0.47	GO:0005737	cytoplasm
0.37	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P43378|PTN9_HUMAN
Tyrosine-protein phosphatase non-receptor type 9
Search

PTPN9

0.95	Tyrosine-protein phosphatase non-receptor type 9

0.73	GO:0035335	peptidyl-tyrosine dephosphorylation
0.47	GO:0043249	erythrocyte maturation
0.47	GO:0060215	primitive hemopoiesis
0.36	GO:1903078	positive regulation of protein localization to plasma membrane
0.36	GO:0010977	negative regulation of neuron projection development
0.35	GO:0071345	cellular response to cytokine stimulus
0.35	GO:0006606	protein import into nucleus

0.73	GO:0004725	protein tyrosine phosphatase activity
0.35	GO:0061608	nuclear import signal receptor activity
0.35	GO:0005515	protein binding

0.59	GO:0044306	neuron projection terminus
0.40	GO:0005737	cytoplasm
0.34	GO:0005654	nucleoplasm

0.73

EC:3.1.3.48

GO:0004725

sp|P43403|ZAP70_HUMAN
Tyrosine-protein kinase ZAP-70
Search

ZAP70

0.59	Tyrosine-protein kinase

0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.61	GO:0035556	intracellular signal transduction
0.57	GO:0045059	positive thymic T cell selection
0.57	GO:0043366	beta selection
0.56	GO:0045582	positive regulation of T cell differentiation
0.55	GO:0046641	positive regulation of alpha-beta T cell proliferation
0.54	GO:0045060	negative thymic T cell selection
0.54	GO:0050850	positive regulation of calcium-mediated signaling
0.54	GO:0046637	regulation of alpha-beta T cell differentiation
0.53	GO:0046777	protein autophosphorylation

0.80	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0008144	drug binding
0.45	GO:0005102	receptor binding
0.39	GO:0001784	phosphotyrosine residue binding
0.38	GO:0042169	SH2 domain binding
0.38	GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity
0.37	GO:0019902	phosphatase binding

0.57	GO:0042101	T cell receptor complex
0.53	GO:0001772	immunological synapse
0.52	GO:0098857	membrane microdomain
0.49	GO:0005911	cell-cell junction
0.48	GO:0005737	cytoplasm
0.46	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.39	GO:0019815	B cell receptor complex
0.36	GO:0097708	intracellular vesicle
0.34	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.80

GO:0004715

sp|P43405|KSYK_HUMAN
Tyrosine-protein kinase SYK
Search

SYK

0.74	Spleen associated tyrosine kinase

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.69	GO:0045399	regulation of interleukin-3 biosynthetic process
0.69	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
0.69	GO:0032752	positive regulation of interleukin-3 production
0.68	GO:0071226	cellular response to molecule of fungal origin
0.67	GO:0043366	beta selection
0.67	GO:0045588	positive regulation of gamma-delta T cell differentiation
0.67	GO:0002554	serotonin secretion by platelet
0.67	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation
0.67	GO:0090237	regulation of arachidonic acid secretion

0.80	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.65	GO:0035325	Toll-like receptor binding
0.64	GO:0042169	SH2 domain binding
0.64	GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity
0.63	GO:0001784	phosphotyrosine residue binding
0.62	GO:0005178	integrin binding
0.61	GO:0019902	phosphatase binding
0.58	GO:0019901	protein kinase binding
0.54	GO:0004674	protein serine/threonine kinase activity
0.53	GO:0030554	adenyl nucleotide binding

0.67	GO:0019815	B cell receptor complex
0.65	GO:0032009	early phagosome
0.64	GO:0042101	T cell receptor complex
0.48	GO:0005634	nucleus
0.48	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane

0.80

GO:0004715

sp|P43487|RANG_HUMAN
Ran-specific GTPase-activating protein
Search

RANBP1

0.89	RAN binding protein 1

0.69	GO:0046907	intracellular transport
0.57	GO:0046604	positive regulation of mitotic centrosome separation
0.52	GO:0007051	spindle organization
0.48	GO:0000082	G1/S transition of mitotic cell cycle
0.48	GO:0006606	protein import into nucleus
0.46	GO:0043547	positive regulation of GTPase activity
0.46	GO:0006405	RNA export from nucleus
0.45	GO:0006511	ubiquitin-dependent protein catabolic process
0.39	GO:0072750	cellular response to leptomycin B
0.38	GO:0051592	response to calcium ion

0.47	GO:0008536	Ran GTPase binding
0.46	GO:0005096	GTPase activator activity
0.38	GO:0005092	GDP-dissociation inhibitor activity
0.37	GO:0045296	cadherin binding

0.51	GO:0005813	centrosome
0.44	GO:0005829	cytosol
0.41	GO:0005634	nucleus
0.38	GO:1904115	axon cytoplasm
0.33	GO:0012505	endomembrane system
0.33	GO:0031967	organelle envelope
0.30	GO:0031224	intrinsic component of membrane

sp|P43489|TNR4_HUMAN
Tumor necrosis factor receptor superfamily member 4
Search

TNFRSF4

0.95	Tumor necrosis factor receptor superfamily member 4

0.57	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.55	GO:0032496	response to lipopolysaccharide
0.53	GO:0006954	inflammatory response
0.52	GO:0006955	immune response
0.52	GO:0097190	apoptotic signaling pathway
0.51	GO:0042127	regulation of cell proliferation
0.50	GO:0042981	regulation of apoptotic process
0.50	GO:0007275	multicellular organism development
0.49	GO:0051047	positive regulation of secretion
0.48	GO:0051090	regulation of DNA binding transcription factor activity

0.59	GO:0005031	tumor necrosis factor-activated receptor activity
0.42	GO:0001618	virus receptor activity
0.42	GO:0019955	cytokine binding
0.34	GO:0031625	ubiquitin protein ligase binding
0.33	GO:0042802	identical protein binding
0.32	GO:0046872	metal ion binding

0.48	GO:0009986	cell surface
0.47	GO:0005887	integral component of plasma membrane
0.44	GO:0098552	side of membrane
0.38	GO:0005829	cytosol
0.33	GO:0005794	Golgi apparatus
0.32	GO:0005634	nucleus

sp|P43490|NAMPT_HUMAN
Nicotinamide phosphoribosyltransferase
Search

NAMPT

0.83	Nicotinamide phosphoribosyltransferase

0.73	GO:0009435	NAD biosynthetic process
0.56	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
0.54	GO:0032922	circadian regulation of gene expression
0.49	GO:0045944	positive regulation of transcription by RNA polymerase II
0.39	GO:0048661	positive regulation of smooth muscle cell proliferation
0.39	GO:0007565	female pregnancy
0.38	GO:0010469	regulation of receptor activity
0.38	GO:0014070	response to organic cyclic compound
0.37	GO:0060612	adipose tissue development
0.37	GO:0008286	insulin receptor signaling pathway

0.77	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity
0.57	GO:0047280	nicotinamide phosphoribosyltransferase activity
0.48	GO:0042802	identical protein binding
0.39	GO:0005125	cytokine activity
0.36	GO:0046983	protein dimerization activity
0.34	GO:0008144	drug binding

0.51	GO:0016607	nuclear speck
0.49	GO:0030054	cell junction
0.38	GO:0005737	cytoplasm
0.37	GO:0005615	extracellular space
0.36	GO:1903561	extracellular vesicle

0.77	EC:2.4.2.19	GO:0004514
0.77	KEGG:R03348	GO:0004514

sp|P43626|KI2L1_HUMAN
Killer cell immunoglobulin-like receptor 2DL1
Search

0.91	Natural killer cell inhibitory receptor

0.39	GO:0006955	immune response
0.38	GO:0050776	regulation of immune response
0.38	GO:0006952	defense response
0.36	GO:0007165	signal transduction

0.39	GO:0030110	HLA-C specific inhibitory MHC class I receptor activity
0.36	GO:0005515	protein binding
0.35	GO:0003823	antigen binding

0.38

GO:0005887

integral component of plasma membrane

sp|P43627|KI2L2_HUMAN
Killer cell immunoglobulin-like receptor 2DL2
Search

0.91	Natural killer cell inhibitory receptor

0.40	GO:0006955	immune response
0.38	GO:0050776	regulation of immune response
0.38	GO:0006952	defense response
0.36	GO:0007165	signal transduction
0.34	GO:0030101	natural killer cell activation

0.39	GO:0032393	MHC class I receptor activity
0.36	GO:0005515	protein binding
0.35	GO:0003823	antigen binding

0.38

GO:0005887

integral component of plasma membrane

sp|P43628|KI2L3_HUMAN
Killer cell immunoglobulin-like receptor 2DL3
Search

0.90	Natural killer cell inhibitory receptor

0.40	GO:0006955	immune response
0.38	GO:0006952	defense response
0.38	GO:0050776	regulation of immune response
0.36	GO:0007165	signal transduction
0.34	GO:0030101	natural killer cell activation

0.39	GO:0032393	MHC class I receptor activity
0.36	GO:0005515	protein binding
0.35	GO:0003823	antigen binding

0.38

GO:0005887

integral component of plasma membrane

sp|P43629|KI3L1_HUMAN
Killer cell immunoglobulin-like receptor 3DL1
Search

KIR3DL1

0.91	Natural killer cell inhibitory receptor

0.36	GO:0006952	defense response
0.35	GO:0006955	immune response
0.35	GO:0001909	leukocyte mediated cytotoxicity
0.35	GO:0050776	regulation of immune response
0.35	GO:0002449	lymphocyte mediated immunity
0.35	GO:0030101	natural killer cell activation
0.34	GO:0007165	signal transduction

0.37	GO:0032393	MHC class I receptor activity
0.35	GO:0001540	amyloid-beta binding
0.35	GO:0005515	protein binding

0.35

GO:0005887

integral component of plasma membrane

sp|P43630|KI3L2_HUMAN
Killer cell immunoglobulin-like receptor 3DL2
Search

KIR3DL2

0.96	Natural killer cell inhibitory receptor

0.35	GO:0006968	cellular defense response
0.35	GO:0050776	regulation of immune response
0.35	GO:0042267	natural killer cell mediated cytotoxicity
0.33	GO:0007165	signal transduction

0.35	GO:0030109	HLA-B specific inhibitory MHC class I receptor activity
0.34	GO:0001540	amyloid-beta binding
0.34	GO:0005515	protein binding

0.34

GO:0005887

integral component of plasma membrane

sp|P43631|KI2S2_HUMAN
Killer cell immunoglobulin-like receptor 2DS2
Search

0.94	Natural killer cell inhibitory receptor

0.40	GO:0006955	immune response
0.38	GO:0006952	defense response
0.38	GO:0050776	regulation of immune response
0.36	GO:0007165	signal transduction
0.34	GO:0030101	natural killer cell activation

0.39	GO:0032393	MHC class I receptor activity
0.36	GO:0005515	protein binding
0.35	GO:0003823	antigen binding

0.38

GO:0005887

integral component of plasma membrane

sp|P43632|KI2S4_HUMAN
Killer cell immunoglobulin-like receptor 2DS4
Search

0.94	Natural killer cell inhibitory receptor

0.40	GO:0006955	immune response
0.38	GO:0050776	regulation of immune response
0.38	GO:0006952	defense response
0.36	GO:0007165	signal transduction
0.34	GO:0030101	natural killer cell activation

0.39	GO:0032393	MHC class I receptor activity
0.36	GO:0005515	protein binding
0.35	GO:0003823	antigen binding

0.38

GO:0005887

integral component of plasma membrane

sp|P43652|AFAM_HUMAN
Afamin
Search

AFM

0.90	LOW QUALITY PROTEIN: afamin

0.64	GO:0071693	protein transport within extracellular region
0.55	GO:0050821	protein stabilization
0.53	GO:0051180	vitamin transport
0.53	GO:0051659	maintenance of mitochondrion location
0.51	GO:0019836	hemolysis by symbiont of host erythrocytes
0.47	GO:0009267	cellular response to starvation
0.47	GO:0043066	negative regulation of apoptotic process
0.43	GO:0001542	ovulation from ovarian follicle
0.43	GO:0042448	progesterone metabolic process
0.42	GO:0060395	SMAD protein signal transduction

0.63	GO:0008431	vitamin E binding
0.50	GO:0005504	fatty acid binding
0.49	GO:0015643	toxic substance binding
0.48	GO:0019825	oxygen binding
0.45	GO:0051087	chaperone binding
0.44	GO:0042802	identical protein binding
0.43	GO:0030170	pyridoxal phosphate binding
0.39	GO:0003677	DNA binding
0.37	GO:0046872	metal ion binding
0.33	GO:0019899	enzyme binding

0.73	GO:0005615	extracellular space
0.48	GO:1903561	extracellular vesicle
0.46	GO:0043209	myelin sheath
0.44	GO:0005794	Golgi apparatus
0.44	GO:0005783	endoplasmic reticulum
0.41	GO:0043234	protein complex
0.35	GO:0060417	yolk
0.35	GO:0031093	platelet alpha granule lumen
0.34	GO:0005604	basement membrane
0.33	GO:0005634	nucleus

sp|P43657|LPAR6_HUMAN
Lysophosphatidic acid receptor 6
Search

LPAR6

0.97	Oleoyl-L-alpha-lysophosphatidic acid receptor

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.50	GO:0035025	positive regulation of Rho protein signal transduction
0.48	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.46	GO:0001525	angiogenesis

0.71	GO:0004930	G-protein coupled receptor activity
0.42	GO:0035727	lysophosphatidic acid binding

0.44	GO:0005886	plasma membrane
0.43	GO:0043227	membrane-bounded organelle
0.42	GO:0043229	intracellular organelle
0.37	GO:0043233	organelle lumen
0.30	GO:0016021	integral component of membrane

sp|P43681|ACHA4_HUMAN
Neuronal acetylcholine receptor subunit alpha-4
Search

CHRNA4

0.93	Cholinergic receptor nicotinic alpha 4 subunit

0.77	GO:0060079	excitatory postsynaptic potential
0.73	GO:0035094	response to nicotine
0.70	GO:0007271	synaptic transmission, cholinergic
0.69	GO:0060080	inhibitory postsynaptic potential
0.68	GO:0014059	regulation of dopamine secretion
0.68	GO:0035640	exploration behavior
0.67	GO:0007585	respiratory gaseous exchange
0.67	GO:0051899	membrane depolarization
0.66	GO:0019233	sensory perception of pain
0.66	GO:0001508	action potential

0.80	GO:0022848	acetylcholine-gated cation-selective channel activity
0.71	GO:0015464	acetylcholine receptor activity
0.57	GO:0042166	acetylcholine binding

0.76	GO:0045211	postsynaptic membrane
0.73	GO:0005892	acetylcholine-gated channel complex
0.72	GO:0030054	cell junction
0.63	GO:0009897	external side of plasma membrane

sp|P43686|PRS6B_HUMAN
26S protease regulatory subunit 6B
Search

PSMC4

0.82	Proteasome (Prosome, macropain) 26S subunit, ATPase, 4

0.81	GO:1901800	positive regulation of proteasomal protein catabolic process
0.69	GO:0030163	protein catabolic process
0.53	GO:0006508	proteolysis
0.52	GO:0001824	blastocyst development
0.48	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
0.46	GO:0034976	response to endoplasmic reticulum stress
0.46	GO:0010243	response to organonitrogen compound
0.44	GO:0043632	modification-dependent macromolecule catabolic process
0.38	GO:0044267	cellular protein metabolic process
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition

0.82	GO:0036402	proteasome-activating ATPase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0008233	peptidase activity
0.47	GO:0017025	TBP-class protein binding

0.56	GO:1905369	endopeptidase complex
0.49	GO:0005829	cytosol
0.48	GO:0043234	protein complex
0.45	GO:0005634	nucleus
0.42	GO:0070013	intracellular organelle lumen
0.39	GO:0044446	intracellular organelle part
0.39	GO:0016234	inclusion body
0.37	GO:0045202	synapse
0.30	GO:0016020	membrane

0.52

GO:0008233

sp|P43694|GATA4_HUMAN
Transcription factor GATA-4
Search

GATA4

0.94	Transcription factor GATA-4

0.68	GO:0045893	positive regulation of transcription, DNA-templated
0.62	GO:0003290	atrial septum secundum morphogenesis
0.62	GO:0060575	intestinal epithelial cell differentiation
0.59	GO:0003197	endocardial cushion development
0.58	GO:0008584	male gonad development
0.55	GO:0006357	regulation of transcription by RNA polymerase II
0.50	GO:0042493	response to drug
0.48	GO:0061026	cardiac muscle tissue regeneration
0.48	GO:0048738	cardiac muscle tissue development
0.47	GO:0003208	cardiac ventricle morphogenesis

0.64	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.61	GO:0070410	co-SMAD binding
0.57	GO:0044212	transcription regulatory region DNA binding
0.55	GO:0003713	transcription coactivator activity
0.54	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding
0.53	GO:0008134	transcription factor binding
0.48	GO:0003690	double-stranded DNA binding
0.47	GO:0003682	chromatin binding

0.58	GO:0005634	nucleus
0.55	GO:0005667	transcription factor complex
0.49	GO:0070013	intracellular organelle lumen
0.44	GO:0044446	intracellular organelle part
0.36	GO:0005694	chromosome

0.33

EC:4.2.99.18

GO:0003906

sp|P43699|NKX21_HUMAN
Homeobox protein Nkx-2.1
Search

NKX2-1

0.90	Thyroid transcription factor 1

0.63	GO:0021536	diencephalon development
0.62	GO:0021761	limbic system development
0.59	GO:0060486	Clara cell differentiation
0.59	GO:0030878	thyroid gland development
0.58	GO:0060510	Type II pneumocyte differentiation
0.58	GO:0021798	forebrain dorsal/ventral pattern formation
0.58	GO:0060430	lung saccule development
0.58	GO:0010719	negative regulation of epithelial to mesenchymal transition
0.58	GO:0021892	cerebral cortex GABAergic interneuron differentiation
0.58	GO:0060441	epithelial tube branching involved in lung morphogenesis

0.64	GO:0043565	sequence-specific DNA binding
0.59	GO:0044213	intronic transcription regulatory region DNA binding
0.55	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.55	GO:0001047	core promoter binding
0.53	GO:0001012	RNA polymerase II regulatory region DNA binding
0.50	GO:0003690	double-stranded DNA binding
0.50	GO:0019899	enzyme binding
0.37	GO:0008134	transcription factor binding
0.36	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.35	GO:0042803	protein homodimerization activity

0.61	GO:0005634	nucleus
0.50	GO:0005667	transcription factor complex
0.39	GO:0070013	intracellular organelle lumen
0.37	GO:0044446	intracellular organelle part

sp|P43897|EFTS_HUMAN
Elongation factor Ts, mitochondrial
Search

TSFM

0.69	Elongation factor Ts, mitochondrial

0.70	GO:0006414	translational elongation
0.59	GO:0070129	regulation of mitochondrial translation
0.49	GO:0032543	mitochondrial translation
0.36	GO:0032784	regulation of DNA-templated transcription, elongation
0.32	GO:0055114	oxidation-reduction process

0.71	GO:0003746	translation elongation factor activity
0.34	GO:0005515	protein binding
0.32	GO:0016491	oxidoreductase activity

0.58	GO:0005739	mitochondrion
0.46	GO:0005634	nucleus
0.44	GO:0031974	membrane-enclosed lumen
0.41	GO:0044446	intracellular organelle part
0.32	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016491

sp|P45378|TNNT3_HUMAN
Troponin T, fast skeletal muscle
Search

TNNT3

0.92	Troponin T fast skeletal muscle type

0.84	GO:0006942	regulation of striated muscle contraction
0.53	GO:0003009	skeletal muscle contraction
0.49	GO:0043462	regulation of ATPase activity
0.36	GO:0030049	muscle filament sliding
0.33	GO:0043043	peptide biosynthetic process
0.33	GO:0044267	cellular protein metabolic process
0.33	GO:0010467	gene expression
0.33	GO:0009059	macromolecule biosynthetic process

0.55	GO:0030899	calcium-dependent ATPase activity
0.54	GO:0030172	troponin C binding
0.54	GO:0031013	troponin I binding
0.52	GO:0048306	calcium-dependent protein binding
0.52	GO:0005523	tropomyosin binding
0.47	GO:0003779	actin binding
0.35	GO:0031014	troponin T binding
0.34	GO:0003735	structural constituent of ribosome

0.83	GO:0005861	troponin complex
0.34	GO:0005829	cytosol
0.34	GO:0005840	ribosome

sp|P45379|TNNT2_HUMAN
Troponin T, cardiac muscle
Search

TNNT2

0.92	Cardiac troponin T

0.83	GO:0006937	regulation of muscle contraction
0.62	GO:0030049	muscle filament sliding
0.61	GO:0055010	ventricular cardiac muscle tissue morphogenesis
0.59	GO:0008016	regulation of heart contraction
0.58	GO:0051592	response to calcium ion
0.57	GO:0060047	heart contraction
0.57	GO:0006941	striated muscle contraction
0.56	GO:0032780	negative regulation of ATPase activity
0.56	GO:0032781	positive regulation of ATPase activity
0.43	GO:0045214	sarcomere organization

0.62	GO:0030172	troponin C binding
0.61	GO:0031013	troponin I binding
0.58	GO:0005523	tropomyosin binding
0.52	GO:0003779	actin binding
0.37	GO:0030674	protein binding, bridging
0.36	GO:0005200	structural constituent of cytoskeleton
0.34	GO:0016887	ATPase activity
0.32	GO:0046872	metal ion binding

0.84	GO:0005861	troponin complex
0.57	GO:0097512	cardiac myofibril
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.34

GO:0016887

sp|P45381|ACY2_HUMAN
Aspartoacylase
Search

ASPA

0.89	Aspartoacylase

0.41	GO:0048714	positive regulation of oligodendrocyte differentiation
0.41	GO:0022010	central nervous system myelination
0.36	GO:0006533	aspartate catabolic process
0.34	GO:0006083	acetate metabolic process
0.33	GO:0008652	cellular amino acid biosynthetic process
0.33	GO:0006805	xenobiotic metabolic process
0.32	GO:0016032	viral process

0.67	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
0.61	GO:0016788	hydrolase activity, acting on ester bonds
0.52	GO:0046872	metal ion binding
0.51	GO:0042802	identical protein binding

0.48	GO:0005829	cytosol
0.39	GO:0005634	nucleus
0.38	GO:0016324	apical plasma membrane
0.38	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.67

EC:3.5.1

GO:0016811

sp|P45452|MMP13_HUMAN
Collagenase 3
Search

MMP13

0.71	Matrix metalloproteinase

0.82	GO:0030574	collagen catabolic process
0.61	GO:0006508	proteolysis
0.59	GO:0022617	extracellular matrix disassembly
0.57	GO:0003417	growth plate cartilage development
0.57	GO:0001958	endochondral ossification
0.56	GO:0030282	bone mineralization
0.43	GO:0010727	negative regulation of hydrogen peroxide metabolic process
0.42	GO:0032461	positive regulation of protein oligomerization
0.42	GO:0044267	cellular protein metabolic process
0.38	GO:0032879	regulation of localization

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.56	GO:0005518	collagen binding
0.50	GO:0005509	calcium ion binding
0.37	GO:0004252	serine-type endopeptidase activity
0.35	GO:0001968	fibronectin binding
0.35	GO:0050750	low-density lipoprotein particle receptor binding
0.35	GO:0048306	calcium-dependent protein binding
0.34	GO:0001047	core promoter binding
0.33	GO:0043565	sequence-specific DNA binding

0.74	GO:0031012	extracellular matrix
0.41	GO:0005581	collagen trimer
0.38	GO:0005615	extracellular space
0.36	GO:0046581	intercellular canaliculus
0.35	GO:0005764	lysosome
0.34	GO:0012505	endomembrane system
0.34	GO:1903561	extracellular vesicle
0.33	GO:0031312	extrinsic component of organelle membrane
0.32	GO:0005634	nucleus
0.32	GO:0031984	organelle subcompartment

0.70

GO:0004222

sp|P45844|ABCG1_HUMAN
ATP-binding cassette sub-family G member 1
Search

ABCG1

0.93	ATP-binding cassette subfamily G member 1 transcription variant 1

0.78	GO:0032367	intracellular cholesterol transport
0.58	GO:0033344	cholesterol efflux
0.58	GO:0034436	glycoprotein transport
0.57	GO:0010874	regulation of cholesterol efflux
0.56	GO:0071403	cellular response to high density lipoprotein particle stimulus
0.56	GO:0033700	phospholipid efflux
0.56	GO:0055091	phospholipid homeostasis
0.56	GO:0042987	amyloid precursor protein catabolic process
0.56	GO:0045542	positive regulation of cholesterol biosynthetic process
0.55	GO:0034374	low-density lipoprotein particle remodeling

0.78	GO:0017127	cholesterol transporter activity
0.61	GO:0034041	sterol-transporting ATPase activity
0.58	GO:0034437	glycoprotein transporter activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0019534	toxin transmembrane transporter activity
0.52	GO:0042803	protein homodimerization activity
0.51	GO:0005548	phospholipid transporter activity
0.51	GO:0046982	protein heterodimerization activity

0.52	GO:0009897	external side of plasma membrane
0.52	GO:0055037	recycling endosome
0.43	GO:0005739	mitochondrion
0.37	GO:0005794	Golgi apparatus
0.34	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0098588	bounding membrane of organelle
0.30	GO:0016021	integral component of membrane

sp|P45877|PPIC_HUMAN
Peptidyl-prolyl cis-trans isomerase C
Search

PPIC

0.47	Peptidyl-prolyl cis-trans isomerase C

0.72	GO:0000413	protein peptidyl-prolyl isomerization
0.69	GO:0006457	protein folding
0.42	GO:0044829	positive regulation by host of viral genome replication
0.41	GO:0040018	positive regulation of multicellular organism growth
0.41	GO:0060348	bone development
0.40	GO:0050821	protein stabilization
0.35	GO:1901873	regulation of post-translational protein modification
0.34	GO:0051169	nuclear transport
0.33	GO:0001525	angiogenesis

0.72	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.57	GO:0016018	cyclosporin A binding
0.39	GO:0070063	RNA polymerase binding
0.38	GO:0032403	protein complex binding
0.32	GO:0003723	RNA binding

0.42	GO:0034663	endoplasmic reticulum chaperone complex
0.40	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0031982	vesicle
0.37	GO:0043230	extracellular organelle
0.36	GO:0005788	endoplasmic reticulum lumen
0.36	GO:0005634	nucleus
0.36	GO:0005615	extracellular space
0.36	GO:0005790	smooth endoplasmic reticulum
0.34	GO:0005925	focal adhesion
0.30	GO:0016020	membrane

0.72

EC:5.2.1.8

GO:0003755

sp|P45880|VDAC2_HUMAN
Voltage-dependent anion-selective channel protein 2
Search

VDAC2

0.95	Voltage-dependent anion-selective channel protein 2

0.68	GO:0098656	anion transmembrane transport
0.53	GO:0007339	binding of sperm to zona pellucida
0.52	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway
0.50	GO:0032272	negative regulation of protein polymerization
0.44	GO:0031101	fin regeneration
0.44	GO:0036444	mitochondrial calcium uptake
0.42	GO:0008016	regulation of heart contraction
0.35	GO:0015866	ADP transport
0.33	GO:0006754	ATP biosynthetic process
0.32	GO:0006412	translation

0.76	GO:0008308	voltage-gated anion channel activity
0.41	GO:0042803	protein homodimerization activity
0.41	GO:0015288	porin activity
0.35	GO:1901265	nucleoside phosphate binding
0.35	GO:0036094	small molecule binding
0.33	GO:0003735	structural constituent of ribosome

0.76	GO:0005741	mitochondrial outer membrane
0.52	GO:0001669	acrosomal vesicle
0.52	GO:0042645	mitochondrial nucleoid
0.51	GO:0043209	myelin sheath
0.43	GO:0019866	organelle inner membrane
0.41	GO:0046930	pore complex
0.38	GO:0070382	exocytic vesicle
0.38	GO:0097458	neuron part
0.37	GO:0045121	membrane raft
0.37	GO:0043230	extracellular organelle

sp|P45954|ACDSB_HUMAN
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Search

ACADSB

0.90	Short/branched chain specific acyl-CoA dehydrogenase

0.51	GO:0055114	oxidation-reduction process
0.38	GO:0006631	fatty acid metabolic process
0.36	GO:0035383	thioester metabolic process
0.35	GO:0046395	carboxylic acid catabolic process
0.34	GO:0006732	coenzyme metabolic process
0.34	GO:0044242	cellular lipid catabolic process
0.34	GO:0009081	branched-chain amino acid metabolic process
0.34	GO:0030258	lipid modification
0.34	GO:1901565	organonitrogen compound catabolic process
0.33	GO:0006793	phosphorus metabolic process

0.71	GO:0003995	acyl-CoA dehydrogenase activity
0.63	GO:0050660	flavin adenine dinucleotide binding
0.33	GO:0009055	electron transfer activity

0.45	GO:0005739	mitochondrion
0.38	GO:0031974	membrane-enclosed lumen
0.37	GO:0070062	extracellular exosome
0.36	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.71

EC:1.3.99.3

GO:0003995

sp|P45973|CBX5_HUMAN
Chromobox protein homolog 5
Search

CBX5

0.96	Chromobox protein like protein 5

0.60	GO:0045892	negative regulation of transcription, DNA-templated
0.48	GO:0006357	regulation of transcription by RNA polymerase II
0.37	GO:0070317	negative regulation of G0 to G1 transition
0.36	GO:0071549	cellular response to dexamethasone stimulus
0.35	GO:0048511	rhythmic process
0.35	GO:0007596	blood coagulation
0.34	GO:0016569	covalent chromatin modification
0.33	GO:0006338	chromatin remodeling
0.33	GO:0016032	viral process
0.33	GO:0006351	transcription, DNA-templated

0.54	GO:0140034	methylation-dependent protein binding
0.54	GO:0070491	repressing transcription factor binding
0.54	GO:0042826	histone deacetylase binding
0.52	GO:0042393	histone binding
0.52	GO:0042802	identical protein binding
0.51	GO:0030674	protein binding, bridging
0.50	GO:0003682	chromatin binding
0.49	GO:0043021	ribonucleoprotein complex binding
0.47	GO:0046983	protein dimerization activity
0.44	GO:1990226	histone methyltransferase binding

0.61	GO:0005634	nucleus
0.60	GO:0000791	euchromatin
0.57	GO:0031974	membrane-enclosed lumen
0.56	GO:0000792	heterochromatin
0.56	GO:0010369	chromocenter
0.53	GO:0000775	chromosome, centromeric region
0.52	GO:0000781	chromosome, telomeric region
0.52	GO:0017053	transcriptional repressor complex
0.50	GO:0034708	methyltransferase complex
0.44	GO:1990904	ribonucleoprotein complex

0.32

GO:0016740

sp|P45974|UBP5_HUMAN
Ubiquitin carboxyl-terminal hydrolase 5
Search

USP5

0.57	Ubiquitinyl hydrolase 1

0.76	GO:0016579	protein deubiquitination
0.72	GO:0006511	ubiquitin-dependent protein catabolic process
0.58	GO:1901800	positive regulation of proteasomal protein catabolic process
0.57	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
0.45	GO:1904378	maintenance of unfolded protein involved in ERAD pathway
0.44	GO:1904888	cranial skeletal system development
0.44	GO:1904292	regulation of ERAD pathway
0.44	GO:1905898	positive regulation of response to endoplasmic reticulum stress
0.44	GO:0009953	dorsal/ventral pattern formation
0.42	GO:0050821	protein stabilization

0.78	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.62	GO:0008270	zinc ion binding
0.58	GO:0043130	ubiquitin binding
0.46	GO:1904454	ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
0.45	GO:1904288	BAT3 complex binding
0.43	GO:0070628	proteasome binding
0.42	GO:0031625	ubiquitin protein ligase binding
0.41	GO:0051087	chaperone binding
0.41	GO:0004197	cysteine-type endopeptidase activity

0.30

GO:0016020

membrane

0.41

GO:0004197

sp|P45983|MK08_HUMAN
Mitogen-activated protein kinase 8
Search

MAPK8

0.58	Mitogen-activated protein kinase

0.79	GO:0000165	MAPK cascade
0.57	GO:1902595	regulation of DNA replication origin binding
0.56	GO:0090045	positive regulation of deacetylase activity
0.55	GO:0031098	stress-activated protein kinase signaling cascade
0.54	GO:0031063	regulation of histone deacetylation
0.54	GO:0031281	positive regulation of cyclase activity
0.54	GO:0071276	cellular response to cadmium ion
0.53	GO:0034198	cellular response to amino acid starvation
0.53	GO:0071260	cellular response to mechanical stimulus
0.53	GO:0032091	negative regulation of protein binding

0.81	GO:0004707	MAP kinase activity
0.58	GO:0035033	histone deacetylase regulator activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.53	GO:0042826	histone deacetylase binding
0.34	GO:0019894	kinesin binding

0.45	GO:0005622	intracellular
0.45	GO:0043005	neuron projection
0.42	GO:0043227	membrane-bounded organelle
0.37	GO:0036477	somatodendritic compartment
0.36	GO:0120038	plasma membrane bounded cell projection part
0.34	GO:0031974	membrane-enclosed lumen
0.34	GO:0044297	cell body
0.34	GO:0044422	organelle part
0.33	GO:0043234	protein complex
0.33	GO:0043228	non-membrane-bounded organelle

0.81	EC:2.7.11.24	GO:0004707
0.81	KEGG:R00162	GO:0004707

sp|P45984|MK09_HUMAN
Mitogen-activated protein kinase 9
Search

MAPK9

0.59	Mitogen-activated protein kinase

0.79	GO:0000165	MAPK cascade
0.58	GO:0071276	cellular response to cadmium ion
0.57	GO:0061833	protein localization to tricellular tight junction
0.57	GO:0031098	stress-activated protein kinase signaling cascade
0.57	GO:0010744	positive regulation of macrophage derived foam cell differentiation
0.56	GO:0071803	positive regulation of podosome assembly
0.56	GO:0018105	peptidyl-serine phosphorylation
0.53	GO:2001235	positive regulation of apoptotic signaling pathway
0.53	GO:0042752	regulation of circadian rhythm
0.53	GO:0034614	cellular response to reactive oxygen species

0.81	GO:0004707	MAP kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.49	GO:0008134	transcription factor binding
0.46	GO:0035033	histone deacetylase regulator activity
0.43	GO:0042826	histone deacetylase binding
0.35	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
0.35	GO:0031435	mitogen-activated protein kinase kinase kinase binding

0.46	GO:0005829	cytosol
0.45	GO:0043005	neuron projection
0.43	GO:0005739	mitochondrion
0.42	GO:0005634	nucleus
0.35	GO:0043204	perikaryon
0.33	GO:0070013	intracellular organelle lumen
0.33	GO:0044446	intracellular organelle part

0.81	EC:2.7.11.24	GO:0004707
0.81	KEGG:R00162	GO:0004707

sp|P45985|MP2K4_HUMAN
Dual specificity mitogen-activated protein kinase kinase 4
Search

MAP2K4

0.92	Dual specificity mitogen-activated protein kinase kinase 4

0.63	GO:0006468	protein phosphorylation
0.54	GO:2000672	negative regulation of motor neuron apoptotic process
0.53	GO:0071260	cellular response to mechanical stimulus
0.53	GO:0034393	positive regulation of smooth muscle cell apoptotic process
0.49	GO:0009611	response to wounding
0.47	GO:0031098	stress-activated protein kinase signaling cascade
0.46	GO:0032147	activation of protein kinase activity
0.44	GO:0007346	regulation of mitotic cell cycle
0.42	GO:0072709	cellular response to sorbitol
0.42	GO:0061049	cell growth involved in cardiac muscle cell development

0.68	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0008545	JUN kinase kinase activity
0.41	GO:0031435	mitogen-activated protein kinase kinase kinase binding
0.36	GO:0004713	protein tyrosine kinase activity
0.33	GO:0003723	RNA binding
0.32	GO:0016787	hydrolase activity

0.41	GO:0032839	dendrite cytoplasm
0.40	GO:0043204	perikaryon
0.39	GO:0030424	axon
0.37	GO:0005829	cytosol
0.36	GO:0005634	nucleus

0.68

GO:0004674

sp|P46013|KI67_HUMAN
Proliferation marker protein Ki-67
Search

MKI67

0.78	Proliferation marker protein Ki-67

0.89	GO:1990705	cholangiocyte proliferation
0.86	GO:0072574	hepatocyte proliferation
0.79	GO:1902275	regulation of chromatin organization
0.78	GO:0051983	regulation of chromosome segregation
0.77	GO:0007088	regulation of mitotic nuclear division
0.76	GO:0051321	meiotic cell cycle

0.81	GO:0008022	protein C-terminus binding
0.55	GO:0003677	DNA binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.30	GO:0003723	RNA binding

0.76	GO:0016604	nuclear body
0.75	GO:0000775	chromosome, centromeric region
0.75	GO:0000793	condensed chromosome
0.72	GO:0005730	nucleolus
0.48	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|P46019|KPB2_HUMAN
Phosphorylase b kinase regulatory subunit alpha, liver isoform
Search

PHKA2

0.67	Phosphorylase b kinase regulatory subunit

0.75	GO:0005977	glycogen metabolic process
0.52	GO:0016310	phosphorylation
0.42	GO:0036211	protein modification process
0.40	GO:0044267	cellular protein metabolic process
0.36	GO:0009251	glucan catabolic process
0.36	GO:0044247	cellular polysaccharide catabolic process
0.32	GO:0007166	cell surface receptor signaling pathway
0.32	GO:0007186	G-protein coupled receptor signaling pathway

0.79	GO:0005516	calmodulin binding
0.54	GO:0016301	kinase activity
0.42	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.41	GO:0140096	catalytic activity, acting on a protein
0.32	GO:0004930	G-protein coupled receptor activity

0.56	GO:0005886	plasma membrane
0.52	GO:0005964	phosphorylase kinase complex
0.35	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.42

GO:0016773

sp|P46020|KPB1_HUMAN
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform
Search

PHKA1

0.67	Phosphorylase b kinase regulatory subunit

0.75	GO:0005977	glycogen metabolic process
0.50	GO:0016310	phosphorylation
0.40	GO:0036211	protein modification process
0.39	GO:0044267	cellular protein metabolic process
0.35	GO:0006657	CDP-choline pathway
0.35	GO:0009251	glucan catabolic process
0.35	GO:0044247	cellular polysaccharide catabolic process
0.34	GO:0098732	macromolecule deacylation
0.34	GO:0016569	covalent chromatin modification
0.32	GO:0006351	transcription, DNA-templated

0.79	GO:0005516	calmodulin binding
0.52	GO:0016301	kinase activity
0.41	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.40	GO:0140096	catalytic activity, acting on a protein
0.36	GO:0004105	choline-phosphate cytidylyltransferase activity
0.34	GO:0019213	deacetylase activity
0.33	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

0.56	GO:0005886	plasma membrane
0.49	GO:0005964	phosphorylase kinase complex
0.34	GO:0005829	cytosol
0.33	GO:0005634	nucleus

0.41

GO:0016773

sp|P46059|S15A1_HUMAN
Solute carrier family 15 member 1
Search

SLC15A1

0.55	Proton-dependent gastrointestinal peptide transporter

0.78	GO:0006857	oligopeptide transport
0.55	GO:0055085	transmembrane transport
0.41	GO:0015804	neutral amino acid transport
0.37	GO:0015031	protein transport
0.36	GO:0051956	negative regulation of amino acid transport
0.35	GO:0007586	digestion
0.34	GO:0042121	alginic acid biosynthetic process
0.34	GO:0065009	regulation of molecular function
0.34	GO:0007264	small GTPase mediated signal transduction
0.33	GO:0015992	proton transport

0.70	GO:0035673	oligopeptide transmembrane transporter activity
0.49	GO:0015291	secondary active transmembrane transporter activity
0.41	GO:0015175	neutral amino acid transmembrane transporter activity
0.35	GO:0016248	channel inhibitor activity
0.34	GO:0005085	guanyl-nucleotide exchange factor activity
0.33	GO:0015078	hydrogen ion transmembrane transporter activity

0.56	GO:0005903	brush border
0.34	GO:0005887	integral component of plasma membrane
0.31	GO:0005622	intracellular

sp|P46060|RAGP1_HUMAN
Ran GTPase-activating protein 1
Search

RANGAP1

0.88	Ran GTPase-activating protein 1

0.74	GO:0043547	positive regulation of GTPase activity
0.61	GO:0046826	negative regulation of protein export from nucleus
0.59	GO:0007165	signal transduction
0.44	GO:1904117	cellular response to vasopressin
0.42	GO:0048678	response to axon injury
0.35	GO:0016925	protein sumoylation
0.35	GO:0007062	sister chromatid cohesion

0.75	GO:0005096	GTPase activator activity
0.56	GO:0045296	cadherin binding
0.55	GO:0008536	Ran GTPase binding
0.45	GO:0003723	RNA binding
0.40	GO:0031625	ubiquitin protein ligase binding

0.58	GO:0016235	aggresome
0.55	GO:0031965	nuclear membrane
0.55	GO:0048471	perinuclear region of cytoplasm
0.54	GO:0000776	kinetochore
0.50	GO:0005829	cytosol
0.42	GO:0044614	nuclear pore cytoplasmic filaments
0.42	GO:1904115	axon cytoplasm
0.41	GO:0030425	dendrite
0.41	GO:0072686	mitotic spindle
0.37	GO:0000779	condensed chromosome, centromeric region

sp|P46063|RECQ1_HUMAN
ATP-dependent DNA helicase Q1
Search

RECQL

0.48	ATP-dependent DNA helicase

0.64	GO:0006310	DNA recombination
0.57	GO:0000733	DNA strand renaturation
0.55	GO:0032508	DNA duplex unwinding
0.47	GO:0006281	DNA repair
0.44	GO:0006260	DNA replication

0.70	GO:0070035	purine NTP-dependent helicase activity
0.63	GO:0042623	ATPase activity, coupled
0.58	GO:0036310	annealing helicase activity
0.55	GO:0003678	DNA helicase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0003677	DNA binding
0.33	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.48	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.42	GO:0005694	chromosome
0.36	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|P46087|NOP2_HUMAN
Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase
Search

NOP2

0.86	LOW QUALITY PROTEIN: putative ribosomal RNA methyltransferase NOP2

0.66	GO:0006364	rRNA processing
0.61	GO:0032259	methylation
0.55	GO:1901796	regulation of signal transduction by p53 class mediator
0.53	GO:0042273	ribosomal large subunit biogenesis
0.52	GO:0008284	positive regulation of cell proliferation
0.51	GO:0042255	ribosome assembly
0.42	GO:0009451	RNA modification
0.36	GO:0044260	cellular macromolecule metabolic process

0.66	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
0.58	GO:0003723	RNA binding
0.45	GO:0008169	C-methyltransferase activity
0.44	GO:0140102	catalytic activity, acting on a rRNA
0.43	GO:0008173	RNA methyltransferase activity
0.35	GO:0005198	structural molecule activity

0.52	GO:0005730	nucleolus
0.37	GO:0005882	intermediate filament
0.30	GO:0031224	intrinsic component of membrane

0.45

GO:0008169

sp|P46089|GPR3_HUMAN
G-protein coupled receptor 3
Search

GPR3

0.91	G-protein coupled receptor 3

0.69	GO:0007186	G-protein coupled receptor signaling pathway
0.56	GO:0040020	regulation of meiotic nuclear division
0.50	GO:0090520	sphingolipid mediated signaling pathway
0.49	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.37	GO:0030816	positive regulation of cAMP metabolic process
0.37	GO:0019933	cAMP-mediated signaling
0.36	GO:1904145	negative regulation of meiotic cell cycle process involved in oocyte maturation
0.35	GO:0008285	negative regulation of cell proliferation

0.70	GO:0004930	G-protein coupled receptor activity
0.33	GO:0005515	protein binding

0.36	GO:0005886	plasma membrane
0.35	GO:0031965	nuclear membrane
0.32	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|P46091|GPR1_HUMAN
G-protein coupled receptor 1
Search

GPR1

0.93	G-protein coupled receptor 1

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.46	GO:0007268	chemical synaptic transmission
0.37	GO:0002430	complement receptor mediated signaling pathway
0.36	GO:0050900	leukocyte migration
0.36	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.36	GO:0060326	cell chemotaxis
0.36	GO:0006954	inflammatory response
0.34	GO:0002283	neutrophil activation involved in immune response
0.33	GO:0006939	smooth muscle contraction
0.33	GO:0042310	vasoconstriction

0.72	GO:0004930	G-protein coupled receptor activity
0.51	GO:0042923	neuropeptide binding
0.37	GO:0004875	complement receptor activity
0.35	GO:0001653	peptide receptor activity
0.34	GO:0005515	protein binding
0.33	GO:0004749	ribose phosphate diphosphokinase activity
0.32	GO:0000287	magnesium ion binding

0.50	GO:0005654	nucleoplasm
0.46	GO:0043005	neuron projection
0.44	GO:0005886	plasma membrane
0.34	GO:0060417	yolk
0.32	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.33	EC:2.7.6.1	GO:0004749
0.33	KEGG:R01049	GO:0004749

sp|P46092|CCR10_HUMAN
C-C chemokine receptor type 10
Search

CCR10

0.97	LOW QUALITY PROTEIN: atypical chemokine receptor 4

0.73	GO:0070098	chemokine-mediated signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.64	GO:0006955	immune response
0.63	GO:0006935	chemotaxis
0.58	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.45	GO:0032460	negative regulation of protein oligomerization
0.45	GO:0000060	protein import into nucleus, translocation
0.44	GO:0051881	regulation of mitochondrial membrane potential
0.44	GO:0033138	positive regulation of peptidyl-serine phosphorylation
0.44	GO:0071456	cellular response to hypoxia

0.77	GO:0008528	G-protein coupled peptide receptor activity
0.71	GO:0004896	cytokine receptor activity
0.44	GO:0099528	G-protein coupled neurotransmitter receptor activity
0.43	GO:0042923	neuropeptide binding
0.38	GO:0001965	G-protein alpha-subunit binding
0.37	GO:0019956	chemokine binding
0.36	GO:0005044	scavenger receptor activity
0.36	GO:0031681	G-protein beta-subunit binding
0.33	GO:0031005	filamin binding
0.33	GO:0008022	protein C-terminus binding

0.54	GO:0009986	cell surface
0.52	GO:0005783	endoplasmic reticulum
0.42	GO:0031226	intrinsic component of plasma membrane
0.40	GO:0043005	neuron projection
0.37	GO:0045203	integral component of cell outer membrane
0.36	GO:0031256	leading edge membrane
0.36	GO:0031253	cell projection membrane
0.36	GO:0098857	membrane microdomain
0.35	GO:0036477	somatodendritic compartment
0.35	GO:0098794	postsynapse

sp|P46093|GPR4_HUMAN
G-protein coupled receptor 4
Search

GPR4

0.97	G protein-coupled receptor 4

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.70	GO:0009268	response to pH
0.62	GO:0072144	glomerular mesangial cell development
0.61	GO:0051093	negative regulation of developmental process
0.61	GO:0051241	negative regulation of multicellular organismal process
0.60	GO:0060055	angiogenesis involved in wound healing
0.60	GO:2000026	regulation of multicellular organismal development
0.56	GO:0023056	positive regulation of signaling
0.56	GO:0010647	positive regulation of cell communication
0.55	GO:0048584	positive regulation of response to stimulus

0.72	GO:0004930	G-protein coupled receptor activity
0.35	GO:0001653	peptide receptor activity

0.44	GO:0005887	integral component of plasma membrane
0.35	GO:0005622	intracellular

sp|P46094|XCR1_HUMAN
Chemokine XC receptor 1
Search

XCR1

0.97	Chemokine XC receptor

0.83	GO:0070098	chemokine-mediated signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.70	GO:0006935	chemotaxis
0.41	GO:0006954	inflammatory response
0.40	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.39	GO:0032845	negative regulation of homeostatic process
0.38	GO:0032879	regulation of localization
0.37	GO:0060401	cytosolic calcium ion transport
0.37	GO:2000021	regulation of ion homeostasis
0.37	GO:0070588	calcium ion transmembrane transport

0.84	GO:0004950	chemokine receptor activity
0.39	GO:0019956	chemokine binding
0.35	GO:0005044	scavenger receptor activity
0.34	GO:0051916	granulocyte colony-stimulating factor binding
0.34	GO:0015026	coreceptor activity
0.33	GO:0004980	melanocyte-stimulating hormone receptor activity
0.33	GO:0008142	oxysterol binding
0.32	GO:0004983	neuropeptide Y receptor activity

0.36	GO:0005887	integral component of plasma membrane
0.35	GO:0042629	mast cell granule
0.35	GO:0005884	actin filament
0.34	GO:0009986	cell surface
0.34	GO:0031965	nuclear membrane
0.34	GO:0055037	recycling endosome
0.34	GO:0005769	early endosome
0.33	GO:0005654	nucleoplasm
0.33	GO:0005829	cytosol

sp|P46095|GPR6_HUMAN
G-protein coupled receptor 6
Search

GPR6

0.66	G-protein coupled receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.55	GO:0090520	sphingolipid mediated signaling pathway
0.55	GO:0006874	cellular calcium ion homeostasis
0.49	GO:0040020	regulation of meiotic nuclear division
0.36	GO:0030816	positive regulation of cAMP metabolic process
0.36	GO:0019933	cAMP-mediated signaling
0.35	GO:1904145	negative regulation of meiotic cell cycle process involved in oocyte maturation
0.34	GO:0008285	negative regulation of cell proliferation

0.72	GO:0004930	G-protein coupled receptor activity
0.42	GO:0031210	phosphatidylcholine binding
0.33	GO:0005515	protein binding

0.36	GO:0005886	plasma membrane
0.34	GO:0031965	nuclear membrane
0.32	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|P46098|5HT3A_HUMAN
5-hydroxytryptamine receptor 3A
Search

HTR3A

0.97	5-hydroxytryptamine type 3A receptor

0.59	GO:0007165	signal transduction
0.59	GO:0034220	ion transmembrane transport
0.45	GO:0006812	cation transport
0.41	GO:0042220	response to cocaine
0.40	GO:0045471	response to ethanol
0.40	GO:0032414	positive regulation of ion transmembrane transporter activity
0.39	GO:0071363	cellular response to growth factor stimulus
0.39	GO:0007268	chemical synaptic transmission
0.35	GO:0060078	regulation of postsynaptic membrane potential

0.73	GO:0015276	ligand-gated ion channel activity
0.68	GO:0004888	transmembrane signaling receptor activity
0.59	GO:0051378	serotonin binding
0.54	GO:0022835	transmitter-gated channel activity
0.53	GO:0140135	mechanosensitive cation channel activity
0.36	GO:0042802	identical protein binding
0.35	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

0.76	GO:0045211	postsynaptic membrane
0.61	GO:1904602	serotonin-activated cation-selective channel complex
0.57	GO:0097610	cell surface furrow
0.55	GO:0032155	cell division site part
0.39	GO:0097458	neuron part
0.39	GO:0030054	cell junction
0.39	GO:0044297	cell body
0.38	GO:0120025	plasma membrane bounded cell projection
0.36	GO:0099501	exocytic vesicle membrane
0.35	GO:0031301	integral component of organelle membrane

sp|P46100|ATRX_HUMAN
Transcriptional regulator ATRX
Search

ATRX

0.89	ATRX, chromatin remodeler

0.78	GO:1901582	positive regulation of telomeric RNA transcription from RNA pol II promoter
0.78	GO:0035128	post-embryonic forelimb morphogenesis
0.77	GO:1901581	negative regulation of telomeric RNA transcription from RNA pol II promoter
0.77	GO:1904908	negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric
0.75	GO:0072711	cellular response to hydroxyurea
0.74	GO:0060009	Sertoli cell development
0.74	GO:1900112	regulation of histone H3-K9 trimethylation
0.74	GO:0010571	positive regulation of nuclear cell cycle DNA replication
0.74	GO:0072520	seminiferous tubule development
0.74	GO:0070198	protein localization to chromosome, telomeric region

0.75	GO:0070087	chromo shadow domain binding
0.72	GO:0015616	DNA translocase activity
0.70	GO:0140034	methylation-dependent protein binding
0.66	GO:0042393	histone binding
0.64	GO:0003682	chromatin binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.73	GO:1990707	nuclear subtelomeric heterochromatin
0.73	GO:0031933	telomeric heterochromatin
0.71	GO:0031618	nuclear pericentric heterochromatin
0.70	GO:0016605	PML body
0.67	GO:0000784	nuclear chromosome, telomeric region
0.67	GO:0000780	condensed nuclear chromosome, centromeric region
0.64	GO:0070603	SWI/SNF superfamily-type complex
0.30	GO:0016020	membrane

sp|P46108|CRK_HUMAN
Adapter molecule crk
Search

CRK

0.93	Proto-oncogene C-crk

0.82	GO:0071538	SH2 domain-mediated complex assembly
0.76	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
0.74	GO:0061045	negative regulation of wound healing
0.73	GO:0048013	ephrin receptor signaling pathway
0.71	GO:0043393	regulation of protein binding
0.71	GO:0032956	regulation of actin cytoskeleton organization
0.71	GO:2000146	negative regulation of cell motility
0.69	GO:0009967	positive regulation of signal transduction
0.66	GO:0043087	regulation of GTPase activity
0.61	GO:0008360	regulation of cell shape

0.80	GO:0042169	SH2 domain binding
0.78	GO:0045309	protein phosphorylated amino acid binding
0.78	GO:0046875	ephrin receptor binding
0.77	GO:0005070	SH3/SH2 adaptor activity
0.75	GO:1990782	protein tyrosine kinase binding
0.73	GO:0043621	protein self-association
0.69	GO:0017124	SH3 domain binding
0.52	GO:0005159	insulin-like growth factor receptor binding
0.51	GO:0097110	scaffold protein binding
0.47	GO:0008092	cytoskeletal protein binding

0.66	GO:0015629	actin cytoskeleton
0.56	GO:0043234	protein complex
0.49	GO:0098857	membrane microdomain
0.41	GO:0070062	extracellular exosome
0.40	GO:0005829	cytosol
0.38	GO:0005886	plasma membrane
0.37	GO:0044430	cytoskeletal part
0.37	GO:0005634	nucleus
0.36	GO:0070013	intracellular organelle lumen
0.34	GO:0019028	viral capsid

sp|P46109|CRKL_HUMAN
Crk-like protein
Search

CRKL

0.97	CRK like proto-oncogene, adaptor protein (Fragment)

0.79	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
0.74	GO:0060017	parathyroid gland development
0.70	GO:0048538	thymus development
0.69	GO:0009887	animal organ morphogenesis
0.67	GO:0008284	positive regulation of cell proliferation
0.67	GO:0009952	anterior/posterior pattern specification
0.65	GO:0001568	blood vessel development
0.65	GO:0007507	heart development
0.59	GO:0007520	myoblast fusion
0.55	GO:0048793	pronephros development

0.78	GO:0045309	protein phosphorylated amino acid binding
0.69	GO:0045296	cadherin binding
0.63	GO:0042802	identical protein binding
0.54	GO:0005070	SH3/SH2 adaptor activity
0.54	GO:0042169	SH2 domain binding
0.53	GO:0046875	ephrin receptor binding
0.51	GO:1990782	protein tyrosine kinase binding
0.50	GO:0043621	protein self-association
0.48	GO:0017124	SH3 domain binding
0.44	GO:0005159	insulin-like growth factor receptor binding

0.60	GO:0005654	nucleoplasm
0.59	GO:0005829	cytosol
0.48	GO:0015629	actin cytoskeleton
0.42	GO:0098857	membrane microdomain
0.42	GO:0043234	protein complex
0.42	GO:0070062	extracellular exosome
0.37	GO:0005768	endosome
0.36	GO:0031463	Cul3-RING ubiquitin ligase complex
0.34	GO:0005886	plasma membrane

sp|P46199|IF2M_HUMAN
Translation initiation factor IF-2, mitochondrial
Search

MTIF2

0.42	Mitochondrial translational initiation factor 2

0.70	GO:0006413	translational initiation
0.40	GO:0032790	ribosome disassembly
0.39	GO:0032543	mitochondrial translation
0.35	GO:0006446	regulation of translational initiation

0.71	GO:0003743	translation initiation factor activity
0.67	GO:0003924	GTPase activity
0.65	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0043024	ribosomal small subunit binding
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0046872	metal ion binding

0.50	GO:0005654	nucleoplasm
0.45	GO:0005739	mitochondrion
0.33	GO:0005840	ribosome

sp|P46379|BAG6_HUMAN
Large proline-rich protein BAG6
Search

BAG6

0.79	BCL2 associated athanogene 6

0.88	GO:0061857	endoplasmic reticulum stress-induced pre-emptive quality control
0.87	GO:1904378	maintenance of unfolded protein involved in ERAD pathway
0.86	GO:1904294	positive regulation of ERAD pathway
0.86	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
0.86	GO:0071712	ER-associated misfolded protein catabolic process
0.86	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.85	GO:0030101	natural killer cell activation
0.85	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
0.85	GO:0071816	tail-anchored membrane protein insertion into ER membrane
0.85	GO:0007130	synaptonemal complex assembly

0.86	GO:1990381	ubiquitin-specific protease binding
0.85	GO:0030544	Hsp70 protein binding
0.85	GO:0051787	misfolded protein binding
0.85	GO:0031593	polyubiquitin modification-dependent protein binding
0.84	GO:0070628	proteasome binding
0.79	GO:0031625	ubiquitin protein ligase binding
0.74	GO:0043022	ribosome binding
0.72	GO:0005102	receptor binding

0.87	GO:0071818	BAT3 complex
0.81	GO:0070062	extracellular exosome
0.70	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

sp|P46439|GSTM5_HUMAN
Glutathione S-transferase Mu 5
Search

0.43	Glutathione S-transferase

0.52	GO:0018916	nitrobenzene metabolic process
0.49	GO:0006749	glutathione metabolic process
0.47	GO:0042178	xenobiotic catabolic process
0.47	GO:0070458	cellular detoxification of nitrogen compound
0.41	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
0.41	GO:0071313	cellular response to caffeine
0.41	GO:0043651	linoleic acid metabolic process
0.41	GO:1901685	glutathione derivative metabolic process
0.41	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
0.41	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

0.78	GO:0004364	glutathione transferase activity
0.50	GO:0043295	glutathione binding
0.48	GO:0042802	identical protein binding
0.45	GO:0019899	enzyme binding
0.44	GO:0046983	protein dimerization activity
0.39	GO:0004602	glutathione peroxidase activity
0.38	GO:0005102	receptor binding
0.33	GO:0003735	structural constituent of ribosome

0.55	GO:0045171	intercellular bridge
0.48	GO:0005829	cytosol
0.40	GO:0016529	sarcoplasmic reticulum
0.34	GO:0043209	myelin sheath
0.34	GO:0070062	extracellular exosome
0.33	GO:0005840	ribosome

0.78

EC:2.5.1.18

GO:0004364

sp|P46459|NSF_HUMAN
Vesicle-fusing ATPase
Search

NSF

0.83	N-ethylmaleimide sensitive factor, vesicle fusing ATPase

0.51	GO:0001921	positive regulation of receptor recycling
0.48	GO:0045732	positive regulation of protein catabolic process
0.47	GO:0033059	cellular pigmentation
0.46	GO:0006813	potassium ion transport
0.45	GO:0051641	cellular localization
0.45	GO:0021700	developmental maturation
0.45	GO:0001654	eye development
0.44	GO:0048933	afferent axon development in posterior lateral line nerve
0.44	GO:0048929	efferent axon development in posterior lateral line nerve
0.44	GO:0048939	anterior lateral line nerve glial cell development

0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0017075	syntaxin-1 binding
0.51	GO:0035255	ionotropic glutamate receptor binding
0.49	GO:0030165	PDZ domain binding
0.49	GO:0019901	protein kinase binding
0.46	GO:0032403	protein complex binding
0.43	GO:0042623	ATPase activity, coupled
0.36	GO:0017137	Rab GTPase binding

0.50	GO:0043209	myelin sheath
0.44	GO:0005829	cytosol
0.41	GO:0005765	lysosomal membrane
0.39	GO:0005886	plasma membrane
0.37	GO:0043198	dendritic shaft
0.36	GO:0014069	postsynaptic density
0.36	GO:0070062	extracellular exosome
0.36	GO:0005795	Golgi stack
0.34	GO:0030496	midbody
0.34	GO:0098793	presynapse

sp|P46527|CDN1B_HUMAN
Cyclin-dependent kinase inhibitor 1B
Search

CDKN1B

0.85	Cyclin dependent kinase inhibitor

0.84	GO:0007050	cell cycle arrest
0.82	GO:0071901	negative regulation of protein serine/threonine kinase activity
0.72	GO:0042127	regulation of cell proliferation
0.62	GO:1902746	regulation of lens fiber cell differentiation
0.62	GO:1904030	negative regulation of cyclin-dependent protein kinase activity
0.60	GO:0071236	cellular response to antibiotic
0.60	GO:0071285	cellular response to lithium ion
0.59	GO:0048102	autophagic cell death
0.59	GO:0007346	regulation of mitotic cell cycle
0.58	GO:0031116	positive regulation of microtubule polymerization

0.85	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
0.56	GO:0019903	protein phosphatase binding
0.56	GO:0030332	cyclin binding
0.54	GO:0019901	protein kinase binding
0.53	GO:0032403	protein complex binding
0.52	GO:0016301	kinase activity
0.41	GO:0030544	Hsp70 protein binding
0.39	GO:0051087	chaperone binding
0.36	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity
0.36	GO:0016773	phosphotransferase activity, alcohol group as acceptor

0.61	GO:0005634	nucleus
0.58	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex
0.50	GO:0005829	cytosol
0.40	GO:0005768	endosome
0.36	GO:0043234	protein complex
0.35	GO:0070013	intracellular organelle lumen
0.35	GO:1902554	serine/threonine protein kinase complex
0.34	GO:0044446	intracellular organelle part
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.32	GO:0005576	extracellular region

0.36

GO:0016773

sp|P46531|NOTC1_HUMAN
Neurogenic locus notch homolog protein 1
Search

NOTCH1

0.90	Receptor protein Notch1

0.82	GO:0007219	Notch signaling pathway
0.71	GO:0030154	cell differentiation
0.69	GO:0007275	multicellular organism development
0.66	GO:0050793	regulation of developmental process
0.59	GO:0097150	neuronal stem cell population maintenance
0.57	GO:0045967	negative regulation of growth rate
0.57	GO:2001027	negative regulation of endothelial cell chemotaxis
0.57	GO:0006355	regulation of transcription, DNA-templated
0.56	GO:0072602	interleukin-4 secretion
0.56	GO:0071372	cellular response to follicle-stimulating hormone stimulus

0.69	GO:0005509	calcium ion binding
0.64	GO:0060089	molecular transducer activity
0.54	GO:0005112	Notch binding
0.53	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.53	GO:0031490	chromatin DNA binding
0.52	GO:0001047	core promoter binding
0.49	GO:0004857	enzyme inhibitor activity
0.49	GO:0046982	protein heterodimerization activity
0.47	GO:0019899	enzyme binding
0.45	GO:0043565	sequence-specific DNA binding

0.56	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex
0.52	GO:0016324	apical plasma membrane
0.51	GO:0005912	adherens junction
0.50	GO:0043235	receptor complex
0.49	GO:0009986	cell surface
0.48	GO:0031410	cytoplasmic vesicle
0.47	GO:0005783	endoplasmic reticulum
0.44	GO:0005634	nucleus
0.39	GO:0005794	Golgi apparatus
0.38	GO:0097223	sperm part

0.33

GO:0016787

sp|P46597|ASMT_HUMAN
Acetylserotonin O-methyltransferase
Search

ASMT

0.91	Acetylserotonin O-methyltransferase

0.63	GO:0032259	methylation
0.55	GO:0030187	melatonin biosynthetic process
0.39	GO:2000019	negative regulation of male gonad development
0.35	GO:0046219	indolalkylamine biosynthetic process
0.34	GO:0043484	regulation of RNA splicing
0.34	GO:0043043	peptide biosynthetic process
0.33	GO:0044267	cellular protein metabolic process
0.33	GO:0010467	gene expression
0.33	GO:0009059	macromolecule biosynthetic process
0.32	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway

0.73	GO:0008171	O-methyltransferase activity
0.48	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
0.45	GO:0042803	protein homodimerization activity
0.45	GO:0047429	nucleoside-triphosphate diphosphatase activity
0.35	GO:0008172	S-methyltransferase activity
0.35	GO:0051018	protein kinase A binding
0.32	GO:0045028	G-protein coupled purinergic nucleotide receptor activity
0.32	GO:0003676	nucleic acid binding

0.37	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.73

GO:0008171

sp|P46663|BKRB1_HUMAN
B1 bradykinin receptor
Search

BDKRB1

0.96	Bradykinin receptor, beta 1

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.70	GO:0009612	response to mechanical stimulus
0.70	GO:0006954	inflammatory response
0.57	GO:0010033	response to organic substance
0.52	GO:0009617	response to bacterium
0.52	GO:0008015	blood circulation
0.52	GO:0006939	smooth muscle contraction
0.51	GO:1901700	response to oxygen-containing compound
0.51	GO:0035296	regulation of tube diameter
0.50	GO:0003018	vascular process in circulatory system

0.81	GO:0004947	bradykinin receptor activity
0.54	GO:0042277	peptide binding
0.50	GO:0004994	somatostatin receptor activity
0.45	GO:0004950	chemokine receptor activity
0.41	GO:0009881	photoreceptor activity
0.41	GO:0031702	type 1 angiotensin receptor binding
0.39	GO:0002020	protease binding
0.38	GO:0046982	protein heterodimerization activity
0.38	GO:0035717	chemokine (C-C motif) ligand 7 binding
0.38	GO:0071791	chemokine (C-C motif) ligand 5 binding

0.43	GO:0005886	plasma membrane
0.42	GO:0043005	neuron projection
0.38	GO:0005768	endosome
0.36	GO:0009986	cell surface
0.36	GO:0098552	side of membrane
0.35	GO:0005783	endoplasmic reticulum
0.34	GO:0043235	receptor complex
0.32	GO:0097731	9+0 non-motile cilium
0.32	GO:0045178	basal part of cell
0.32	GO:0044441	ciliary part

0.36	EC:3.1.4.11	GO:0004435
0.36	KEGG:R03435	GO:0004435

sp|P46695|IEX1_HUMAN
Radiation-inducible immediate-early gene IEX-1
Search

IER3

0.94	Radiation-inducible immediate-early protein IEX-1

0.78	GO:0043066	negative regulation of apoptotic process
0.64	GO:2001020	regulation of response to DNA damage stimulus
0.46	GO:0045820	negative regulation of glycolytic process
0.46	GO:0003085	negative regulation of systemic arterial blood pressure
0.46	GO:1901028	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
0.45	GO:0001562	response to protozoan
0.45	GO:0007095	mitotic G2 DNA damage checkpoint
0.45	GO:0010823	negative regulation of mitochondrion organization
0.44	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
0.44	GO:0050728	negative regulation of inflammatory response

0.35

GO:0005515

protein binding

0.52	GO:0005634	nucleus
0.38	GO:0005739	mitochondrion
0.36	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|P46721|SO1A2_HUMAN
Solute carrier organic anion transporter family member 1A2
Search

SLCO1A2

0.62	Solute carrier organic anion transporter family member

0.58	GO:0006811	ion transport
0.55	GO:0055085	transmembrane transport
0.46	GO:0071702	organic substance transport
0.42	GO:0010876	lipid localization
0.41	GO:0070327	thyroid hormone transport
0.41	GO:0035634	response to stilbenoid
0.40	GO:0031100	animal organ regeneration
0.39	GO:0033574	response to testosterone
0.38	GO:0050892	intestinal absorption
0.37	GO:0008206	bile acid metabolic process

0.57	GO:0015347	sodium-independent organic anion transmembrane transporter activity
0.47	GO:0015125	bile acid transmembrane transporter activity
0.42	GO:0015349	thyroid hormone transmembrane transporter activity
0.36	GO:0015350	methotrexate transmembrane transporter activity

0.55	GO:0005886	plasma membrane
0.37	GO:0005903	brush border
0.36	GO:0120038	plasma membrane bounded cell projection part
0.30	GO:0016021	integral component of membrane

sp|P46734|MP2K3_HUMAN
Dual specificity mitogen-activated protein kinase kinase 3
Search

MAP2K3

0.96	Dual specificity mitogen-activated protein kinase kinase 3

0.62	GO:0006468	protein phosphorylation
0.58	GO:0060048	cardiac muscle contraction
0.57	GO:0000187	activation of MAPK activity
0.56	GO:0031098	stress-activated protein kinase signaling cascade
0.53	GO:0043536	positive regulation of blood vessel endothelial cell migration
0.53	GO:0035924	cellular response to vascular endothelial growth factor stimulus
0.52	GO:0042035	regulation of cytokine biosynthetic process
0.51	GO:0006954	inflammatory response
0.48	GO:0010557	positive regulation of macromolecule biosynthetic process
0.48	GO:0051254	positive regulation of RNA metabolic process

0.67	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0004708	MAP kinase kinase activity
0.54	GO:0019901	protein kinase binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0004713	protein tyrosine kinase activity
0.35	GO:0042802	identical protein binding

0.42	GO:0005829	cytosol
0.40	GO:0005634	nucleus
0.35	GO:0005856	cytoskeleton
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.67

GO:0004674

sp|P46736|BRCC3_HUMAN
Lys-63-specific deubiquitinase BRCC36
Search

BRCC3

0.75	BRCA1/BRCA2-containing complex subunit 3

0.85	GO:0070536	protein K63-linked deubiquitination
0.71	GO:0072425	signal transduction involved in G2 DNA damage checkpoint
0.71	GO:0010165	response to X-ray
0.69	GO:0045739	positive regulation of DNA repair
0.68	GO:0016578	histone deubiquitination
0.65	GO:0006281	DNA repair
0.57	GO:0050790	regulation of catalytic activity
0.48	GO:0001525	angiogenesis

0.80	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.69	GO:0031593	polyubiquitin modification-dependent protein binding
0.58	GO:0030234	enzyme regulator activity
0.56	GO:0008237	metallopeptidase activity

0.85	GO:0070552	BRISC complex
0.85	GO:0070531	BRCA1-A complex
0.65	GO:0000152	nuclear ubiquitin ligase complex
0.58	GO:0005654	nucleoplasm
0.43	GO:0005737	cytoplasm

sp|P46776|RL27A_HUMAN
60S ribosomal protein L27a
Search

RPL27A

0.80	Ribosomal protein L27a

0.59	GO:0043043	peptide biosynthetic process
0.55	GO:0044267	cellular protein metabolic process
0.53	GO:0010467	gene expression
0.52	GO:0009059	macromolecule biosynthetic process
0.34	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0007528	neuromuscular junction development
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.34	GO:0019083	viral transcription
0.33	GO:0016072	rRNA metabolic process
0.33	GO:0042254	ribosome biogenesis

0.63	GO:0003735	structural constituent of ribosome
0.41	GO:0003723	RNA binding
0.34	GO:0008270	zinc ion binding
0.33	GO:0005515	protein binding

0.66	GO:0015934	large ribosomal subunit
0.48	GO:0022626	cytosolic ribosome
0.41	GO:0005783	endoplasmic reticulum
0.30	GO:0031224	intrinsic component of membrane

sp|P46777|RL5_HUMAN
60S ribosomal protein L5
Search

RPL5

0.61	Ribosomal protein L5 (Predicted)

0.60	GO:0006518	peptide metabolic process
0.60	GO:0043604	amide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:1901566	organonitrogen compound biosynthetic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.48	GO:0000027	ribosomal large subunit assembly
0.47	GO:2000435	negative regulation of protein neddylation
0.46	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.46	GO:1904667	negative regulation of ubiquitin protein ligase activity

0.79	GO:0008097	5S rRNA binding
0.64	GO:0003735	structural constituent of ribosome
0.47	GO:1990948	ubiquitin ligase inhibitor activity
0.44	GO:0003730	mRNA 3'-UTR binding
0.44	GO:0048027	mRNA 5'-UTR binding
0.43	GO:0031625	ubiquitin protein ligase binding
0.34	GO:0017048	Rho GTPase binding
0.33	GO:0016301	kinase activity
0.33	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.32	GO:0140096	catalytic activity, acting on a protein

0.61	GO:0005840	ribosome
0.45	GO:0005829	cytosol
0.44	GO:0005730	nucleolus
0.41	GO:0005783	endoplasmic reticulum
0.41	GO:0005654	nucleoplasm
0.38	GO:0043234	protein complex
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.33

GO:0016773

sp|P46778|RL21_HUMAN
60S ribosomal protein L21
Search

RPL21

0.70	Ribosomal protein L21

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.36	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.35	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.35	GO:0019083	viral transcription
0.34	GO:0016072	rRNA metabolic process
0.34	GO:0042254	ribosome biogenesis

0.64	GO:0003735	structural constituent of ribosome
0.35	GO:0005515	protein binding
0.34	GO:0003723	RNA binding
0.33	GO:0016787	hydrolase activity

0.61	GO:0005840	ribosome
0.41	GO:0044445	cytosolic part
0.37	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.33

GO:0016787

sp|P46779|RL28_HUMAN
60S ribosomal protein L28
Search

RPL28

0.73	Ribosomal protein L28

0.60	GO:0006518	peptide metabolic process
0.59	GO:0043604	amide biosynthetic process
0.55	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.54	GO:1901566	organonitrogen compound biosynthetic process
0.52	GO:0009059	macromolecule biosynthetic process
0.44	GO:1903146	regulation of autophagy of mitochondrion
0.44	GO:1903955	positive regulation of protein targeting to mitochondrion
0.37	GO:0043009	chordate embryonic development
0.35	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

0.63	GO:0003735	structural constituent of ribosome
0.34	GO:0003723	RNA binding
0.33	GO:0005200	structural constituent of cytoskeleton
0.33	GO:0016787	hydrolase activity
0.33	GO:0005515	protein binding
0.33	GO:0005509	calcium ion binding
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005840	ribosome
0.45	GO:0044445	cytosolic part
0.43	GO:0030425	dendrite
0.43	GO:0044297	cell body
0.42	GO:0036464	cytoplasmic ribonucleoprotein granule
0.40	GO:0044446	intracellular organelle part
0.36	GO:0070062	extracellular exosome
0.33	GO:0099512	supramolecular fiber
0.33	GO:0015630	microtubule cytoskeleton
0.31	GO:0005634	nucleus

0.33

GO:0016787

sp|P46781|RS9_HUMAN
40S ribosomal protein S9
Search

RPS9

0.45	Ribosomal protein S9 (Predicted)

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.48	GO:0045903	positive regulation of translational fidelity
0.48	GO:0008284	positive regulation of cell proliferation
0.35	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.35	GO:0034660	ncRNA metabolic process
0.34	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane

0.66	GO:0019843	rRNA binding
0.64	GO:0003735	structural constituent of ribosome
0.49	GO:0045182	translation regulator activity
0.36	GO:0000213	tRNA-intron endonuclease activity
0.33	GO:0005515	protein binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0008144	drug binding

0.70	GO:0015935	small ribosomal subunit
0.50	GO:0022626	cytosolic ribosome
0.46	GO:0005730	nucleolus
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.35	GO:0000228	nuclear chromosome
0.33	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.36

EC:3.1.27.9

GO:0000213

sp|P46782|RS5_HUMAN
40S ribosomal protein S5
Search

RPS5

0.73	Ribosomal protein S5

0.58	GO:0043043	peptide biosynthetic process
0.54	GO:0044267	cellular protein metabolic process
0.52	GO:0010467	gene expression
0.51	GO:0009059	macromolecule biosynthetic process
0.46	GO:0006450	regulation of translational fidelity
0.45	GO:0000028	ribosomal small subunit assembly
0.35	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.34	GO:0019083	viral transcription
0.33	GO:0016072	rRNA metabolic process

0.62	GO:0003735	structural constituent of ribosome
0.57	GO:0003723	RNA binding
0.34	GO:0005515	protein binding

0.67	GO:0015935	small ribosomal subunit
0.50	GO:0022626	cytosolic ribosome
0.36	GO:0031012	extracellular matrix
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.34	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|P46783|RS10_HUMAN
40S ribosomal protein S10
Search

RPS10

0.68	40S ribosomal small subunit protein S10

0.56	GO:0000028	ribosomal small subunit assembly
0.35	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.35	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.34	GO:0019083	viral transcription
0.34	GO:0006413	translational initiation
0.34	GO:0006364	rRNA processing

0.46	GO:0003735	structural constituent of ribosome
0.44	GO:0003723	RNA binding
0.35	GO:0005515	protein binding
0.34	GO:0016787	hydrolase activity
0.33	GO:0046872	metal ion binding

0.59	GO:0005840	ribosome
0.53	GO:0044445	cytosolic part
0.46	GO:0005730	nucleolus
0.37	GO:0031012	extracellular matrix
0.37	GO:0005925	focal adhesion
0.37	GO:0070062	extracellular exosome
0.34	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.34

GO:0016787

sp|P46821|MAP1B_HUMAN
Microtubule-associated protein 1B
Search

MAP1B

0.93	Microtubule-associated protein 1B

0.76	GO:0000226	microtubule cytoskeleton organization
0.74	GO:0007399	nervous system development
0.60	GO:0047497	mitochondrion transport along microtubule
0.60	GO:0061162	establishment of monopolar cell polarity
0.59	GO:0032387	negative regulation of intracellular transport
0.58	GO:0061387	regulation of extent of cell growth
0.58	GO:0010770	positive regulation of cell morphogenesis involved in differentiation
0.57	GO:0016358	dendrite development
0.57	GO:0048588	developmental cell growth
0.57	GO:0030307	positive regulation of cell growth

0.74	GO:0008017	microtubule binding
0.38	GO:0005519	cytoskeletal regulatory protein binding
0.36	GO:0005543	phospholipid binding
0.36	GO:0032403	protein complex binding
0.36	GO:0003779	actin binding
0.35	GO:0005198	structural molecule activity

0.73	GO:0005874	microtubule
0.58	GO:0001750	photoreceptor outer segment
0.57	GO:0014069	postsynaptic density
0.50	GO:0005829	cytosol
0.43	GO:0005886	plasma membrane
0.43	GO:0043197	dendritic spine
0.42	GO:0097441	basal dendrite
0.42	GO:0097457	hippocampal mossy fiber
0.42	GO:0097440	apical dendrite
0.41	GO:0005875	microtubule associated complex

sp|P46926|GNPI1_HUMAN
Glucosamine-6-phosphate isomerase 1
Search

GNPDA1

0.72	Glucosamine-6-phosphate isomerase

0.78	GO:0006044	N-acetylglucosamine metabolic process
0.60	GO:0005975	carbohydrate metabolic process
0.58	GO:0006043	glucosamine catabolic process
0.43	GO:0006091	generation of precursor metabolites and energy
0.36	GO:0007338	single fertilization
0.34	GO:0006002	fructose 6-phosphate metabolic process
0.33	GO:0044283	small molecule biosynthetic process
0.32	GO:1901576	organic substance biosynthetic process

0.80	GO:0004342	glucosamine-6-phosphate deaminase activity
0.34	GO:0005515	protein binding

0.49	GO:0005737	cytoplasm
0.37	GO:0070062	extracellular exosome
0.33	GO:0005634	nucleus

0.80	EC:3.5.99.6	GO:0004342
0.80	KEGG:R00765	GO:0004342

sp|P46934|NEDD4_HUMAN
E3 ubiquitin-protein ligase NEDD4
Search

NEDD4

0.47	E3 ubiquitin-protein ligase

0.73	GO:0016567	protein ubiquitination
0.71	GO:0006511	ubiquitin-dependent protein catabolic process
0.49	GO:0010768	negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
0.48	GO:2000650	negative regulation of sodium ion transmembrane transporter activity
0.48	GO:0050847	progesterone receptor signaling pathway
0.48	GO:0019089	transmission of virus
0.47	GO:0042921	glucocorticoid receptor signaling pathway
0.47	GO:0006622	protein targeting to lysosome
0.47	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
0.47	GO:0044111	development involved in symbiotic interaction

0.74	GO:0061630	ubiquitin protein ligase activity
0.60	GO:0016874	ligase activity
0.48	GO:0050816	phosphothreonine residue binding
0.48	GO:0031698	beta-2 adrenergic receptor binding
0.48	GO:0019871	sodium channel inhibitor activity
0.47	GO:0035255	ionotropic glutamate receptor binding
0.47	GO:0050815	phosphoserine residue binding
0.47	GO:0070064	proline-rich region binding
0.45	GO:0043130	ubiquitin binding
0.44	GO:0070063	RNA polymerase binding

0.46	GO:0043197	dendritic spine
0.44	GO:0048471	perinuclear region of cytoplasm
0.43	GO:0000151	ubiquitin ligase complex
0.43	GO:0005938	cell cortex
0.42	GO:0000785	chromatin
0.42	GO:0005794	Golgi apparatus
0.41	GO:0005829	cytosol
0.38	GO:0005886	plasma membrane
0.33	GO:0005771	multivesicular body
0.32	GO:0070062	extracellular exosome

0.60

EC:6

GO:0016874

sp|P46937|YAP1_HUMAN
Transcriptional coactivator YAP1
Search

YAP1

0.82	Transcriptional coactivator YAP1-A

0.80	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation
0.79	GO:0060449	bud elongation involved in lung branching
0.79	GO:1902459	positive regulation of stem cell population maintenance
0.77	GO:0048368	lateral mesoderm development
0.77	GO:0046620	regulation of organ growth
0.77	GO:0060487	lung epithelial cell differentiation
0.77	GO:0048339	paraxial mesoderm development
0.77	GO:2000737	negative regulation of stem cell differentiation
0.77	GO:0010837	regulation of keratinocyte proliferation
0.76	GO:0030857	negative regulation of epithelial cell differentiation

0.77	GO:0070064	proline-rich region binding
0.72	GO:0008022	protein C-terminus binding
0.70	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.69	GO:0003713	transcription coactivator activity
0.68	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding
0.67	GO:0003682	chromatin binding
0.62	GO:0033613	activating transcription factor binding
0.60	GO:0003714	transcription corepressor activity
0.56	GO:0046982	protein heterodimerization activity

0.68	GO:0071148	TEAD-1-YAP complex
0.67	GO:0071149	TEAD-2-YAP complex
0.61	GO:0005829	cytosol
0.49	GO:0005654	nucleoplasm
0.45	GO:0000785	chromatin
0.30	GO:0016020	membrane

sp|P46939|UTRO_HUMAN
Utrophin
Search

UTRN

0.89	Rattus norvegicus utrophin

0.67	GO:0001954	positive regulation of cell-matrix adhesion
0.47	GO:0014877	response to muscle inactivity involved in regulation of muscle adaptation
0.45	GO:0007528	neuromuscular junction development
0.45	GO:0007527	adult somatic muscle development
0.40	GO:2000649	regulation of sodium ion transmembrane transporter activity
0.37	GO:0006936	muscle contraction
0.37	GO:0007517	muscle organ development
0.33	GO:0051603	proteolysis involved in cellular protein catabolic process

0.71	GO:0003779	actin binding
0.69	GO:0017166	vinculin binding
0.65	GO:0005178	integrin binding
0.61	GO:0019901	protein kinase binding
0.61	GO:0008270	zinc ion binding
0.34	GO:0070003	threonine-type peptidase activity
0.33	GO:0004175	endopeptidase activity

0.71	GO:0045211	postsynaptic membrane
0.68	GO:0031527	filopodium membrane
0.67	GO:0030054	cell junction
0.65	GO:0070938	contractile ring
0.65	GO:0031594	neuromuscular junction
0.65	GO:0042383	sarcolemma
0.64	GO:0016010	dystrophin-associated glycoprotein complex
0.62	GO:0005856	cytoskeleton
0.55	GO:0005654	nucleoplasm
0.46	GO:0005737	cytoplasm

sp|P46940|IQGA1_HUMAN
Ras GTPase-activating-like protein IQGAP1
Search

IQGAP1

0.90	IQ motif containing GTPase activating protein 1

0.75	GO:0043087	regulation of GTPase activity
0.66	GO:0071364	cellular response to epidermal growth factor stimulus
0.64	GO:0071277	cellular response to calcium ion
0.64	GO:0007173	epidermal growth factor receptor signaling pathway
0.64	GO:1990138	neuron projection extension
0.60	GO:0071902	positive regulation of protein serine/threonine kinase activity
0.60	GO:0036120	cellular response to platelet-derived growth factor stimulus
0.59	GO:0048008	platelet-derived growth factor receptor signaling pathway
0.58	GO:0007346	regulation of mitotic cell cycle
0.57	GO:0008543	fibroblast growth factor receptor signaling pathway

0.65	GO:0044548	S100 protein binding
0.65	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.64	GO:0043539	protein serine/threonine kinase activator activity
0.63	GO:0019903	protein phosphatase binding
0.61	GO:0045296	cadherin binding
0.60	GO:0005516	calmodulin binding
0.59	GO:0019901	protein kinase binding
0.58	GO:0048365	Rac GTPase binding
0.58	GO:0019904	protein domain specific binding
0.36	GO:0032403	protein complex binding

0.62	GO:0001726	ruffle
0.62	GO:0030496	midbody
0.60	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.60	GO:0036464	cytoplasmic ribonucleoprotein granule
0.58	GO:0016328	lateral plasma membrane
0.56	GO:0043005	neuron projection
0.56	GO:0005874	microtubule
0.54	GO:0005911	cell-cell junction
0.49	GO:0030427	site of polarized growth
0.49	GO:0005634	nucleus

sp|P46952|3HAO_HUMAN
3-hydroxyanthranilate 3,4-dioxygenase
Search

HAAO

0.61	3-hydroxyanthranilate 3,4-dioxygenase

0.71	GO:0043420	anthranilate metabolic process
0.71	GO:0034354	'de novo' NAD biosynthetic process from tryptophan
0.69	GO:0046874	quinolinate metabolic process
0.68	GO:0006569	tryptophan catabolic process
0.62	GO:0043650	dicarboxylic acid biosynthetic process
0.58	GO:0070050	neuron cellular homeostasis
0.57	GO:0010043	response to zinc ion
0.55	GO:0046686	response to cadmium ion
0.53	GO:0055114	oxidation-reduction process
0.34	GO:0007186	G-protein coupled receptor signaling pathway

0.85	GO:0000334	3-hydroxyanthranilate 3,4-dioxygenase activity
0.70	GO:0008198	ferrous iron binding
0.35	GO:0019825	oxygen binding
0.34	GO:0004930	G-protein coupled receptor activity
0.34	GO:0005515	protein binding
0.33	GO:0009055	electron transfer activity

0.48	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.33	GO:0031966	mitochondrial membrane
0.30	GO:0031224	intrinsic component of membrane

0.85	EC:1.13.11.6	GO:0000334
0.85	KEGG:R02665	GO:0000334

sp|P46976|GLYG_HUMAN
Glycogenin-1
Search

GYG1

0.86	Glycogenin

0.38	GO:0005978	glycogen biosynthetic process
0.35	GO:0043312	neutrophil degranulation
0.35	GO:0005980	glycogen catabolic process
0.33	GO:0006508	proteolysis

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.35	GO:0046872	metal ion binding
0.34	GO:0005536	glucose binding
0.34	GO:0004181	metallocarboxypeptidase activity
0.33	GO:0005515	protein binding

0.36	GO:0070062	extracellular exosome
0.36	GO:1904813	ficolin-1-rich granule lumen
0.36	GO:0043202	lysosomal lumen
0.35	GO:0034774	secretory granule lumen
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.65

EC:2.4

GO:0016757

sp|P46977|STT3A_HUMAN
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
Search

STT3A

0.90	STT3A, catalytic subunit of the oligosaccharyltransferase complex

0.76	GO:0043686	co-translational protein modification
0.74	GO:0043413	macromolecule glycosylation
0.74	GO:0009101	glycoprotein biosynthetic process
0.73	GO:0018196	peptidyl-asparagine modification
0.51	GO:0043687	post-translational protein modification

0.83

GO:0004576

oligosaccharyl transferase activity

0.52	GO:0008250	oligosaccharyltransferase complex
0.30	GO:0031224	intrinsic component of membrane

0.83

GO:0004576

sp|P47211|GALR1_HUMAN
Galanin receptor type 1
Search

GALR1

0.97	Galanin receptor

0.81	GO:0007194	negative regulation of adenylate cyclase activity
0.75	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.74	GO:0007218	neuropeptide signaling pathway
0.58	GO:0051464	positive regulation of cortisol secretion
0.50	GO:0045944	positive regulation of transcription by RNA polymerase II
0.47	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
0.38	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.35	GO:0007586	digestion

0.83	GO:0004966	galanin receptor activity
0.56	GO:0017046	peptide hormone binding
0.39	GO:0042923	neuropeptide binding
0.33	GO:0005515	protein binding

0.42	GO:0005887	integral component of plasma membrane
0.33	GO:0005622	intracellular

sp|P47224|MSS4_HUMAN
Guanine nucleotide exchange factor MSS4
Search

RABIF

0.95	RAB interacting factor

0.77	GO:0007264	small GTPase mediated signal transduction
0.66	GO:0065009	regulation of molecular function
0.49	GO:0006892	post-Golgi vesicle-mediated transport
0.43	GO:0061865	polarized secretion of basement membrane proteins in epithelium
0.37	GO:0015031	protein transport
0.34	GO:0061025	membrane fusion
0.33	GO:0007017	microtubule-based process
0.33	GO:0007010	cytoskeleton organization
0.32	GO:0000956	nuclear-transcribed mRNA catabolic process
0.32	GO:0000398	mRNA splicing, via spliceosome

0.75	GO:0005085	guanyl-nucleotide exchange factor activity
0.48	GO:0008270	zinc ion binding
0.40	GO:0017137	Rab GTPase binding
0.33	GO:0003677	DNA binding
0.33	GO:0005200	structural constituent of cytoskeleton
0.32	GO:0003924	GTPase activity
0.32	GO:0032550	purine ribonucleoside binding
0.32	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0005622	intracellular
0.41	GO:0045178	basal part of cell
0.35	GO:0071944	cell periphery
0.33	GO:0043227	membrane-bounded organelle
0.33	GO:0099512	supramolecular fiber
0.32	GO:0043228	non-membrane-bounded organelle
0.32	GO:0044422	organelle part
0.32	GO:1990904	ribonucleoprotein complex
0.30	GO:0016020	membrane

sp|P47710|CASA1_HUMAN
Alpha-S1-casein
Search

CSN1S1

0.93	Alpha-S1-casein

0.39	GO:1903456	positive regulation of androst-4-ene-3,17-dione biosynthetic process
0.39	GO:2000837	regulation of androstenedione secretion
0.39	GO:2000184	positive regulation of progesterone biosynthetic process
0.38	GO:2000872	positive regulation of progesterone secretion
0.38	GO:1903496	response to 11-deoxycorticosterone
0.38	GO:1903494	response to dehydroepiandrosterone
0.37	GO:0032570	response to progesterone
0.37	GO:0060416	response to growth hormone
0.37	GO:0032355	response to estradiol
0.36	GO:0055085	transmembrane transport

0.35	GO:0001540	amyloid-beta binding
0.34	GO:0016209	antioxidant activity

0.66	GO:0005576	extracellular region
0.38	GO:0005796	Golgi lumen
0.30	GO:0031224	intrinsic component of membrane

sp|P47712|PA24A_HUMAN
Cytosolic phospholipase A2
Search

PLA2G4A

0.66	Cytosolic phospholipase A2

0.80	GO:0009395	phospholipid catabolic process
0.58	GO:0071236	cellular response to antibiotic
0.56	GO:0046456	icosanoid biosynthetic process
0.54	GO:0050482	arachidonic acid secretion
0.51	GO:0042127	regulation of cell proliferation
0.43	GO:2000045	regulation of G1/S transition of mitotic cell cycle
0.37	GO:0019369	arachidonic acid metabolic process
0.37	GO:0022602	ovulation cycle process
0.36	GO:0008585	female gonad development
0.36	GO:0036150	phosphatidylserine acyl-chain remodeling

0.82	GO:0102568	phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
0.82	GO:0102567	phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
0.79	GO:0004623	phospholipase A2 activity
0.57	GO:0005544	calcium-dependent phospholipid binding
0.53	GO:0046872	metal ion binding
0.45	GO:0004622	lysophospholipase activity
0.35	GO:0035035	histone acetyltransferase binding
0.35	GO:0008970	phosphatidylcholine 1-acylhydrolase activity

0.56	GO:0005811	lipid droplet
0.49	GO:0005829	cytosol
0.49	GO:0005794	Golgi apparatus
0.49	GO:0005783	endoplasmic reticulum
0.42	GO:0031410	cytoplasmic vesicle
0.35	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.34	GO:0031984	organelle subcompartment
0.33	GO:0031966	mitochondrial membrane
0.33	GO:0019866	organelle inner membrane

0.79

EC:3.1.1.4

GO:0004623

sp|P47736|RPGP1_HUMAN
Rap1 GTPase-activating protein 1
Search

RAP1GAP

0.86	Rap1 GTPase-activating protein 1

0.76	GO:0051056	regulation of small GTPase mediated signal transduction
0.76	GO:0043547	positive regulation of GTPase activity
0.40	GO:1903697	negative regulation of microvillus assembly
0.40	GO:1904441	regulation of thyroid gland epithelial cell proliferation
0.40	GO:1990790	response to glial cell derived neurotrophic factor
0.39	GO:1904425	negative regulation of GTP binding
0.38	GO:0050680	negative regulation of epithelial cell proliferation
0.38	GO:0048699	generation of neurons
0.37	GO:0051961	negative regulation of nervous system development
0.37	GO:0010721	negative regulation of cell development

0.76	GO:0005096	GTPase activator activity
0.37	GO:0017016	Ras GTPase binding
0.37	GO:0042803	protein homodimerization activity
0.36	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.34	GO:0003924	GTPase activity

0.37	GO:0005829	cytosol
0.37	GO:0043025	neuronal cell body
0.37	GO:0030425	dendrite
0.37	GO:0005769	early endosome
0.37	GO:0030424	axon
0.36	GO:0000139	Golgi membrane

sp|P47755|CAZA2_HUMAN
F-actin-capping protein subunit alpha-2
Search

CAPZA2

0.89	F-actin-capping protein subunit alpha-2

0.80	GO:0051016	barbed-end actin filament capping
0.36	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.35	GO:0007596	blood coagulation
0.35	GO:0034329	cell junction assembly
0.35	GO:0045087	innate immune response
0.35	GO:0006888	ER to Golgi vesicle-mediated transport
0.34	GO:0006461	protein complex assembly

0.71

GO:0003779

actin binding

0.80	GO:0008290	F-actin capping protein complex
0.49	GO:0005903	brush border
0.48	GO:0030863	cortical cytoskeleton
0.37	GO:0070062	extracellular exosome
0.35	GO:0005829	cytosol
0.35	GO:0030018	Z disc
0.35	GO:0071203	WASH complex
0.30	GO:0016020	membrane

sp|P47756|CAPZB_HUMAN
F-actin-capping protein subunit beta
Search

CAPZB

0.80	Capping actin protein of muscle Z-line beta subunit

0.84	GO:0051016	barbed-end actin filament capping
0.73	GO:0030036	actin cytoskeleton organization
0.61	GO:0031115	negative regulation of microtubule polymerization
0.60	GO:0090036	regulation of protein kinase C signaling
0.60	GO:0030032	lamellipodium assembly
0.59	GO:0048747	muscle fiber development
0.55	GO:0031175	neuron projection development
0.50	GO:0051490	negative regulation of filopodium assembly
0.48	GO:0010591	regulation of lamellipodium assembly
0.44	GO:0000902	cell morphogenesis

0.74	GO:0003779	actin binding
0.58	GO:0048487	beta-tubulin binding
0.55	GO:0032403	protein complex binding

0.84	GO:0008290	F-actin capping protein complex
0.59	GO:0014704	intercalated disc
0.58	GO:0001669	acrosomal vesicle
0.58	GO:0005903	brush border
0.58	GO:0030018	Z disc
0.57	GO:0030027	lamellipodium
0.56	GO:0030863	cortical cytoskeleton
0.47	GO:0005884	actin filament
0.30	GO:0016020	membrane

sp|P47775|GPR12_HUMAN
G-protein coupled receptor 12
Search

GPR12

0.66	G-protein coupled receptor

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.55	GO:0006874	cellular calcium ion homeostasis
0.42	GO:0090520	sphingolipid mediated signaling pathway
0.36	GO:0040020	regulation of meiotic nuclear division

0.71	GO:0004930	G-protein coupled receptor activity
0.57	GO:0031210	phosphatidylcholine binding

0.34	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

sp|P47804|RGR_HUMAN
RPE-retinal G protein-coupled receptor
Search

RGR

0.97	RPE-retinal G protein-coupled receptor

0.78	GO:0007602	phototransduction
0.77	GO:0007601	visual perception
0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.68	GO:0018298	protein-chromophore linkage
0.48	GO:0009584	detection of visible light

0.73	GO:0009881	photoreceptor activity
0.71	GO:0004930	G-protein coupled receptor activity
0.34	GO:0005515	protein binding

0.49

GO:0005887

integral component of plasma membrane

sp|P47813|IF1AX_HUMAN
Eukaryotic translation initiation factor 1A, X-chromosomal
Search

0.83	Eukaryotic translation initiation factor 1A Y-linked

0.72	GO:0006413	translational initiation
0.37	GO:0000226	microtubule cytoskeleton organization
0.36	GO:0006468	protein phosphorylation
0.36	GO:0035556	intracellular signal transduction

0.73	GO:0003743	translation initiation factor activity
0.37	GO:0004674	protein serine/threonine kinase activity
0.36	GO:0000287	magnesium ion binding
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0043023	ribosomal large subunit binding
0.34	GO:0005515	protein binding

0.36	GO:0015630	microtubule cytoskeleton
0.33	GO:0005829	cytosol

0.37

GO:0004674

sp|P47869|GBRA2_HUMAN
Gamma-aminobutyric acid receptor subunit alpha-2
Search

GABRA2

0.97	Gamma-aminobutyric acid receptor subunit alpha-2

0.85	GO:0007214	gamma-aminobutyric acid signaling pathway
0.77	GO:0006821	chloride transport
0.60	GO:0034220	ion transmembrane transport
0.47	GO:0060078	regulation of postsynaptic membrane potential
0.39	GO:0071420	cellular response to histamine
0.39	GO:0051932	synaptic transmission, GABAergic
0.36	GO:0006836	neurotransmitter transport
0.36	GO:0001505	regulation of neurotransmitter levels

0.84	GO:0004890	GABA-A receptor activity
0.76	GO:0005230	extracellular ligand-gated ion channel activity
0.51	GO:0099095	ligand-gated anion channel activity
0.48	GO:0005254	chloride channel activity
0.48	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
0.47	GO:0022835	transmitter-gated channel activity
0.40	GO:0008503	benzodiazepine receptor activity
0.34	GO:0008144	drug binding
0.34	GO:0005515	protein binding

0.57	GO:1902711	GABA-A receptor complex
0.56	GO:0005886	plasma membrane
0.53	GO:0060077	inhibitory synapse
0.51	GO:0098794	postsynapse
0.50	GO:0043025	neuronal cell body
0.50	GO:0030425	dendrite
0.50	GO:0030424	axon
0.42	GO:0034707	chloride channel complex
0.41	GO:0030659	cytoplasmic vesicle membrane
0.40	GO:0030054	cell junction

sp|P47870|GBRB2_HUMAN
Gamma-aminobutyric acid receptor subunit beta-2
Search

GABRB2

0.85	Gamma-aminobutyric acid receptor subunit beta-2

0.69	GO:0060384	innervation
0.68	GO:0090102	cochlea development
0.67	GO:0060119	inner ear receptor cell development
0.66	GO:0043524	negative regulation of neuron apoptotic process
0.64	GO:0007605	sensory perception of sound
0.61	GO:0007165	signal transduction
0.60	GO:0034220	ion transmembrane transport
0.50	GO:0071420	cellular response to histamine
0.45	GO:0006821	chloride transport
0.44	GO:0051932	synaptic transmission, GABAergic

0.84	GO:0004890	GABA-A receptor activity
0.76	GO:0005230	extracellular ligand-gated ion channel activity
0.45	GO:0005254	chloride channel activity
0.38	GO:0099095	ligand-gated anion channel activity
0.37	GO:0005515	protein binding
0.36	GO:0022835	transmitter-gated channel activity

0.55	GO:0005886	plasma membrane
0.55	GO:1902711	GABA-A receptor complex
0.45	GO:0098794	postsynapse
0.45	GO:0034707	chloride channel complex
0.43	GO:0030054	cell junction
0.42	GO:0031410	cytoplasmic vesicle
0.41	GO:0012506	vesicle membrane
0.39	GO:0005829	cytosol
0.39	GO:0070062	extracellular exosome
0.37	GO:0044446	intracellular organelle part

sp|P47871|GLR_HUMAN
Glucagon receptor
Search

GCGR

0.96	Glucagon receptor a

0.77	GO:0071377	cellular response to glucagon stimulus
0.68	GO:0007166	cell surface receptor signaling pathway
0.68	GO:0007186	G-protein coupled receptor signaling pathway
0.59	GO:0010906	regulation of glucose metabolic process
0.57	GO:0019933	cAMP-mediated signaling
0.56	GO:0032881	regulation of polysaccharide metabolic process
0.54	GO:0043467	regulation of generation of precursor metabolites and energy
0.54	GO:0042593	glucose homeostasis
0.52	GO:0042594	response to starvation
0.38	GO:0006887	exocytosis

0.78	GO:0004967	glucagon receptor activity
0.61	GO:0016519	gastric inhibitory peptide receptor activity
0.49	GO:0017046	peptide hormone binding
0.39	GO:0044508	glucagon-like peptide 1 receptor activity
0.35	GO:0005085	guanyl-nucleotide exchange factor activity
0.34	GO:0003735	structural constituent of ribosome

0.52	GO:0005886	plasma membrane
0.38	GO:0005768	endosome
0.33	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

sp|P47872|SCTR_HUMAN
Secretin receptor
Search

SCTR

0.97	Secretin receptor transcript variant 1

0.71	GO:0007166	cell surface receptor signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.37	GO:0007588	excretion
0.37	GO:0007586	digestion
0.37	GO:0043950	positive regulation of cAMP-mediated signaling
0.36	GO:0007420	brain development

0.72	GO:0004930	G-protein coupled receptor activity
0.36	GO:0042277	peptide binding

0.63	GO:0005881	cytoplasmic microtubule
0.51	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P47874|OMP_HUMAN
Olfactory marker protein
Search

OMP

0.97	Olfactory marker protein a

0.76	GO:0007608	sensory perception of smell
0.61	GO:0007165	signal transduction
0.45	GO:0098916	anterograde trans-synaptic signaling
0.44	GO:0022008	neurogenesis
0.38	GO:0006508	proteolysis

0.64	GO:0004871	signal transducer activity
0.44	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.37	GO:0042277	peptide binding
0.35	GO:0005515	protein binding

0.49	GO:0043025	neuronal cell body
0.48	GO:0030424	axon
0.44	GO:0005829	cytosol
0.41	GO:0005634	nucleus

sp|P47881|OR3A1_HUMAN
Olfactory receptor 3A1
Search

0.45	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P47883|OR3A4_HUMAN
Putative olfactory receptor 3A4
Search

0.47	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P47884|OR1D4_HUMAN
Olfactory receptor 1D4
Search

0.44	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.38	GO:0000060	protein import into nucleus, translocation
0.35	GO:0007338	single fertilization
0.34	GO:0006935	chemotaxis

0.76	GO:0004984	olfactory receptor activity
0.72	GO:0004930	G-protein coupled receptor activity
0.36	GO:0042802	identical protein binding
0.33	GO:0005549	odorant binding

0.55	GO:0005886	plasma membrane
0.32	GO:0005622	intracellular
0.30	GO:0031224	intrinsic component of membrane

sp|P47887|OR1E2_HUMAN
Olfactory receptor 1E2
Search

0.45	Olfactory receptor

0.75	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.70	GO:0007186	G-protein coupled receptor signaling pathway

0.75	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P47888|OR3A3_HUMAN
Olfactory receptor 3A3
Search

0.45	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P47890|OR1G1_HUMAN
Olfactory receptor 1G1
Search

0.43	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P47893|OR3A2_HUMAN
Olfactory receptor 3A2
Search

0.45	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.72	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P47895|AL1A3_HUMAN
Aldehyde dehydrogenase family 1 member A3
Search

ALDH1A3

0.40	Aldehyde dehydrogenase

0.61	GO:0021768	nucleus accumbens development
0.61	GO:0002138	retinoic acid biosynthetic process
0.60	GO:0042574	retinal metabolic process
0.60	GO:0060166	olfactory pit development
0.59	GO:0070384	Harderian gland development
0.59	GO:0031076	embryonic camera-type eye development
0.59	GO:0060324	face development
0.59	GO:0060013	righting reflex
0.57	GO:0016331	morphogenesis of embryonic epithelium
0.57	GO:0048048	embryonic eye morphogenesis

0.69	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.58	GO:0070324	thyroid hormone binding
0.52	GO:0070403	NAD+ binding
0.51	GO:0042803	protein homodimerization activity
0.34	GO:0004745	retinol dehydrogenase activity
0.33	GO:0016301	kinase activity

0.49	GO:0005829	cytosol
0.45	GO:0005634	nucleus
0.42	GO:0005886	plasma membrane
0.36	GO:0070062	extracellular exosome

0.69

GO:0016620

sp|P47897|SYQ_HUMAN
Glutamine--tRNA ligase
Search

QARS

0.50	Glutaminyl-tRNA synthetase

0.81	GO:0006425	glutaminyl-tRNA aminoacylation
0.55	GO:0032873	negative regulation of stress-activated MAPK cascade
0.54	GO:2001234	negative regulation of apoptotic signaling pathway
0.53	GO:0006469	negative regulation of protein kinase activity
0.52	GO:0007420	brain development
0.49	GO:0045892	negative regulation of transcription, DNA-templated
0.34	GO:0045727	positive regulation of translation

0.81	GO:0004819	glutamine-tRNA ligase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0004860	protein kinase inhibitor activity
0.51	GO:0019901	protein kinase binding
0.33	GO:0003723	RNA binding

0.56	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex
0.49	GO:0005737	cytoplasm
0.34	GO:0070013	intracellular organelle lumen
0.33	GO:0044446	intracellular organelle part
0.33	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016020	membrane

0.81

EC:6.1.1.18

GO:0004819

sp|P47898|5HT5A_HUMAN
5-hydroxytryptamine receptor 5A
Search

HTR5A

0.97	5-hydroxytryptamine (Serotonin) receptor 5A, G protein-coupled

0.83	GO:0098664	G-protein coupled serotonin receptor signaling pathway
0.58	GO:0019933	cAMP-mediated signaling
0.49	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.41	GO:0032355	response to estradiol
0.41	GO:0021766	hippocampus development

0.83	GO:0099589	serotonin receptor activity
0.80	GO:0099528	G-protein coupled neurotransmitter receptor activity
0.80	GO:0008227	G-protein coupled amine receptor activity
0.51	GO:0051378	serotonin binding
0.33	GO:0008144	drug binding

0.62	GO:0005887	integral component of plasma membrane
0.41	GO:0043204	perikaryon
0.40	GO:0005791	rough endoplasmic reticulum
0.40	GO:0030425	dendrite
0.38	GO:0005794	Golgi apparatus

sp|P47900|P2RY1_HUMAN
P2Y purinoceptor 1
Search

P2RY1

0.97	Purinergic receptor P2Y, G-protein coupled 1

0.85	GO:0090075	relaxation of muscle
0.85	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
0.85	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
0.83	GO:0030168	platelet activation
0.68	GO:0043270	positive regulation of ion transport
0.65	GO:0071407	cellular response to organic cyclic compound
0.48	GO:0070257	positive regulation of mucus secretion
0.47	GO:0097746	regulation of blood vessel diameter
0.40	GO:0060406	positive regulation of penile erection
0.40	GO:0010700	negative regulation of norepinephrine secretion

0.85	GO:0045028	G-protein coupled purinergic nucleotide receptor activity
0.40	GO:0045032	ADP-activated adenosine receptor activity
0.40	GO:0031686	A1 adenosine receptor binding
0.40	GO:0045031	ATP-activated adenosine receptor activity
0.39	GO:0097110	scaffold protein binding
0.37	GO:0043531	ADP binding
0.37	GO:0046982	protein heterodimerization activity
0.34	GO:0005524	ATP binding

0.49	GO:0005886	plasma membrane
0.38	GO:0014069	postsynaptic density
0.38	GO:0030425	dendrite
0.38	GO:0044297	cell body
0.38	GO:0045177	apical part of cell
0.35	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

sp|P47901|V1BR_HUMAN
Vasopressin V1b receptor
Search

AVPR1B

0.92	Pituitary vasotocin receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.66	GO:0001992	regulation of systemic arterial blood pressure by vasopressin
0.52	GO:0045907	positive regulation of vasoconstriction
0.50	GO:1901652	response to peptide
0.47	GO:0009725	response to hormone
0.47	GO:0071495	cellular response to endogenous stimulus
0.46	GO:0071310	cellular response to organic substance
0.41	GO:0042711	maternal behavior
0.41	GO:0045777	positive regulation of blood pressure
0.40	GO:0007204	positive regulation of cytosolic calcium ion concentration

0.85	GO:0005000	vasopressin receptor activity
0.48	GO:0042277	peptide binding
0.48	GO:0004990	oxytocin receptor activity
0.39	GO:0042562	hormone binding
0.38	GO:0031894	V1A vasopressin receptor binding
0.36	GO:0005080	protein kinase C binding
0.34	GO:0042803	protein homodimerization activity

0.54	GO:0005886	plasma membrane
0.38	GO:0043204	perikaryon
0.36	GO:0031410	cytoplasmic vesicle
0.35	GO:0005902	microvillus
0.35	GO:0005913	cell-cell adherens junction
0.35	GO:0045177	apical part of cell
0.34	GO:0012505	endomembrane system
0.33	GO:0043005	neuron projection
0.33	GO:0012506	vesicle membrane
0.32	GO:0044446	intracellular organelle part

sp|P47902|CDX1_HUMAN
Homeobox protein CDX-1
Search

CDX1

0.94	Homeobox protein CHOX-CAD

0.65	GO:0007275	multicellular organism development
0.63	GO:0014807	regulation of somitogenesis
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:0009653	anatomical structure morphogenesis
0.53	GO:0006366	transcription by RNA polymerase II
0.53	GO:0051254	positive regulation of RNA metabolic process
0.52	GO:0010557	positive regulation of macromolecule biosynthetic process
0.52	GO:0031328	positive regulation of cellular biosynthetic process

0.64	GO:0043565	sequence-specific DNA binding
0.59	GO:0035326	enhancer binding
0.59	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
0.57	GO:0001012	RNA polymerase II regulatory region DNA binding
0.54	GO:0003690	double-stranded DNA binding
0.40	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.40	GO:0003714	transcription corepressor activity
0.35	GO:0005328	neurotransmitter:sodium symporter activity
0.34	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.40	GO:0017053	transcriptional repressor complex
0.39	GO:0000793	condensed chromosome
0.37	GO:0043233	organelle lumen
0.36	GO:0043234	protein complex
0.35	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

sp|P47914|RL29_HUMAN
60S ribosomal protein L29
Search

RPL29

0.71	60S ribosomal protein L29

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.36	GO:0035264	multicellular organism growth
0.36	GO:0031589	cell-substrate adhesion
0.36	GO:0008283	cell proliferation
0.35	GO:0007566	embryo implantation
0.35	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0000188	inactivation of MAPK activity

0.64	GO:0003735	structural constituent of ribosome
0.44	GO:0045296	cadherin binding
0.38	GO:0008201	heparin binding
0.34	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
0.34	GO:0003723	RNA binding
0.32	GO:0016301	kinase activity

0.61	GO:0005840	ribosome
0.48	GO:0044445	cytosolic part
0.42	GO:0044446	intracellular organelle part
0.36	GO:0005844	polysome
0.35	GO:0019898	extrinsic component of membrane
0.35	GO:0005791	rough endoplasmic reticulum
0.34	GO:0098562	cytoplasmic side of membrane
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.34	GO:0098588	bounding membrane of organelle
0.33	GO:1902493	acetyltransferase complex

0.34

EC:3.1.3

GO:0017017

sp|P47928|ID4_HUMAN
DNA-binding protein inhibitor ID-4
Search

ID4

0.92	DNA-binding protein inhibitor

0.71	GO:0045892	negative regulation of transcription, DNA-templated
0.58	GO:0048715	negative regulation of oligodendrocyte differentiation
0.58	GO:0045667	regulation of osteoblast differentiation
0.57	GO:0061682	seminal vesicle morphogenesis
0.57	GO:0048710	regulation of astrocyte differentiation
0.57	GO:0007623	circadian rhythm
0.57	GO:0014003	oligodendrocyte development
0.57	GO:0060741	prostate gland stromal morphogenesis
0.56	GO:0045665	negative regulation of neuron differentiation
0.56	GO:0045598	regulation of fat cell differentiation

0.68	GO:0046983	protein dimerization activity
0.52	GO:0001085	RNA polymerase II transcription factor binding
0.44	GO:0003677	DNA binding
0.44	GO:0044325	ion channel binding
0.42	GO:0043621	protein self-association
0.38	GO:0043425	bHLH transcription factor binding
0.38	GO:0140110	transcription regulator activity
0.36	GO:0047485	protein N-terminus binding
0.36	GO:0070628	proteasome binding
0.36	GO:0008022	protein C-terminus binding

0.61	GO:0005634	nucleus
0.49	GO:0005737	cytoplasm
0.39	GO:0012505	endomembrane system
0.39	GO:0070013	intracellular organelle lumen
0.38	GO:0043234	protein complex
0.37	GO:0044446	intracellular organelle part
0.35	GO:0015630	microtubule cytoskeleton
0.33	GO:0005694	chromosome

sp|P47929|LEG7_HUMAN
Galectin-7
Search

0.64

Galectin

0.79	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
0.39	GO:0006915	apoptotic process
0.34	GO:0006508	proteolysis

0.70	GO:0030246	carbohydrate binding
0.36	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.34	GO:0005509	calcium ion binding

0.68	GO:0005615	extracellular space
0.38	GO:1903561	extracellular vesicle
0.36	GO:0005634	nucleus
0.34	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|P47944|MT4_HUMAN
Metallothionein-4
Search

0.77	Metallothionein A

0.53	GO:0006875	cellular metal ion homeostasis
0.42	GO:0010038	response to metal ion
0.36	GO:0001525	angiogenesis
0.36	GO:0071241	cellular response to inorganic substance
0.36	GO:0045926	negative regulation of growth
0.35	GO:0051597	response to methylmercury
0.35	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis
0.35	GO:0010575	positive regulation of vascular endothelial growth factor production

0.54

GO:0046872

metal ion binding

0.36	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0005829	cytosol
0.34	GO:0005634	nucleus

sp|P47972|NPTX2_HUMAN
Neuronal pentraxin-2
Search

NPTX2

0.97	Neuronal pentraxin IIb

0.73	GO:0008306	associative learning
0.55	GO:0060385	axonogenesis involved in innervation
0.52	GO:0050804	modulation of chemical synaptic transmission
0.50	GO:0042752	regulation of circadian rhythm
0.43	GO:0065008	regulation of biological quality
0.40	GO:0007268	chemical synaptic transmission
0.38	GO:0035865	cellular response to potassium ion
0.38	GO:0043653	mitochondrial fragmentation involved in apoptotic process
0.37	GO:0071331	cellular response to hexose stimulus
0.37	GO:0009749	response to glucose

0.41	GO:0030246	carbohydrate binding
0.39	GO:0046872	metal ion binding

0.41	GO:0031410	cytoplasmic vesicle
0.40	GO:0005576	extracellular region
0.40	GO:0012505	endomembrane system
0.39	GO:0043202	lysosomal lumen
0.39	GO:0031983	vesicle lumen
0.38	GO:0097223	sperm part
0.36	GO:0043005	neuron projection
0.34	GO:0005739	mitochondrion
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P47974|TISD_HUMAN
mRNA decay activator protein ZFP36L2
Search

ZFP36L2

0.96	Butyrate response factor 2

0.65	GO:0061158	3'-UTR-mediated mRNA destabilization
0.64	GO:1904628	cellular response to phorbol 13-acetate 12-myristate
0.63	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus
0.63	GO:0045577	regulation of B cell differentiation
0.63	GO:0070371	ERK1 and ERK2 cascade
0.63	GO:2000737	negative regulation of stem cell differentiation
0.63	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
0.63	GO:0060216	definitive hemopoiesis
0.63	GO:0071364	cellular response to epidermal growth factor stimulus
0.62	GO:0048103	somatic stem cell division

0.65	GO:0035925	mRNA 3'-UTR AU-rich region binding
0.54	GO:0046872	metal ion binding
0.38	GO:0071889	14-3-3 protein binding
0.36	GO:0003677	DNA binding
0.35	GO:0003700	DNA binding transcription factor activity

0.48	GO:0005634	nucleus
0.43	GO:0005829	cytosol
0.39	GO:0030529	intracellular ribonucleoprotein complex
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016020	membrane

sp|P47985|UCRI_HUMAN
Cytochrome b-c1 complex subunit Rieske, mitochondrial
Search

UQCRFS1

0.69	Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

0.61	GO:0022900	electron transport chain
0.37	GO:0009725	response to hormone
0.37	GO:0046677	response to antibiotic
0.36	GO:0042493	response to drug
0.33	GO:0006119	oxidative phosphorylation
0.33	GO:0045333	cellular respiration

0.74	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
0.71	GO:0051537	2 iron, 2 sulfur cluster binding
0.62	GO:0009055	electron transfer activity
0.38	GO:0046872	metal ion binding
0.37	GO:0032403	protein complex binding

0.61	GO:0070469	respiratory chain
0.61	GO:0031966	mitochondrial membrane
0.61	GO:0019866	organelle inner membrane
0.47	GO:0098798	mitochondrial protein complex
0.46	GO:0070069	cytochrome complex
0.45	GO:1990204	oxidoreductase complex
0.42	GO:0098796	membrane protein complex
0.40	GO:0043209	myelin sheath
0.30	GO:0031224	intrinsic component of membrane

0.74

EC:1.10.2

GO:0016681

sp|P47989|XDH_HUMAN
Xanthine dehydrogenase/oxidase
Search

XDH

0.51	XDH xanthine dehydrogenase

0.64	GO:0009115	xanthine catabolic process
0.62	GO:2001213	negative regulation of vasculogenesis
0.60	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway
0.60	GO:0045602	negative regulation of endothelial cell differentiation
0.59	GO:1900745	positive regulation of p38MAPK cascade
0.58	GO:0022900	electron transport chain
0.58	GO:0001937	negative regulation of endothelial cell proliferation
0.58	GO:0051898	negative regulation of protein kinase B signaling
0.57	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
0.57	GO:2000379	positive regulation of reactive oxygen species metabolic process

0.80	GO:0016727	oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor
0.79	GO:0004854	xanthine dehydrogenase activity
0.74	GO:0043546	molybdopterin cofactor binding
0.69	GO:0051537	2 iron, 2 sulfur cluster binding
0.65	GO:0050660	flavin adenine dinucleotide binding
0.64	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
0.62	GO:0005506	iron ion binding
0.59	GO:0009055	electron transfer activity
0.52	GO:0042803	protein homodimerization activity
0.51	GO:0030151	molybdenum ion binding

0.55	GO:0016529	sarcoplasmic reticulum
0.45	GO:0005829	cytosol
0.43	GO:0005615	extracellular space
0.40	GO:0005777	peroxisome
0.37	GO:0002197	xanthine dehydrogenase complex
0.30	GO:0031224	intrinsic component of membrane

0.80

EC:1.17.3

GO:0016727

sp|P47992|XCL1_HUMAN
Lymphotactin
Search

0.94	Chemokine C motif ligand 1

0.82	GO:0060326	cell chemotaxis
0.74	GO:0006955	immune response
0.62	GO:0072676	lymphocyte migration
0.58	GO:2000557	regulation of immunoglobulin production in mucosal tissue
0.58	GO:2000554	regulation of T-helper 1 cell cytokine production
0.58	GO:2000412	positive regulation of thymocyte migration
0.58	GO:2000537	regulation of B cell chemotaxis
0.57	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation
0.57	GO:0071674	mononuclear cell migration
0.57	GO:2000503	positive regulation of natural killer cell chemotaxis

0.84	GO:0008009	chemokine activity
0.57	GO:0048020	CCR chemokine receptor binding
0.37	GO:0042803	protein homodimerization activity
0.34	GO:0030276	clathrin binding
0.34	GO:0035091	phosphatidylinositol binding
0.33	GO:0003779	actin binding

0.66	GO:0005576	extracellular region
0.34	GO:0030136	clathrin-coated vesicle

sp|P48023|TNFL6_HUMAN
Tumor necrosis factor ligand superfamily member 6
Search

FASLG

0.97	Tumor necrosis factor ligand superfamily member 6

0.73	GO:0006955	immune response
0.71	GO:0006915	apoptotic process
0.69	GO:0010469	regulation of receptor activity
0.67	GO:1903514	release of sequestered calcium ion into cytosol by endoplasmic reticulum
0.67	GO:0097527	necroptotic signaling pathway
0.66	GO:2000353	positive regulation of endothelial cell apoptotic process
0.66	GO:0046666	retinal cell programmed cell death
0.63	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
0.62	GO:0016525	negative regulation of angiogenesis
0.62	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling

0.83	GO:0005164	tumor necrosis factor receptor binding
0.73	GO:0005125	cytokine activity
0.45	GO:0005123	death receptor binding
0.32	GO:0005249	voltage-gated potassium channel activity
0.32	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0032555	purine ribonucleotide binding
0.31	GO:0003723	RNA binding

0.68	GO:0005615	extracellular space
0.60	GO:1903561	extracellular vesicle
0.59	GO:0009897	external side of plasma membrane
0.49	GO:0043202	lysosomal lumen
0.49	GO:0005634	nucleus
0.49	GO:0060205	cytoplasmic vesicle lumen
0.43	GO:0005901	caveola
0.42	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0005887	integral component of plasma membrane
0.32	GO:0034705	potassium channel complex

sp|P48029|SC6A8_HUMAN
Sodium- and chloride-dependent creatine transporter 1
Search

SLC6A8

0.66	Sodium- and chloride-dependent creatine transporter 1

0.78	GO:1902598	creatine transmembrane transport
0.76	GO:0006836	neurotransmitter transport
0.51	GO:0006814	sodium ion transport
0.48	GO:1990403	embryonic brain development
0.44	GO:0015695	organic cation transport
0.44	GO:0015696	ammonium transport
0.43	GO:0006600	creatine metabolic process
0.41	GO:0006936	muscle contraction

0.79	GO:0005328	neurotransmitter:sodium symporter activity
0.78	GO:0005309	creatine:sodium symporter activity
0.47	GO:0015220	choline transmembrane transporter activity

0.58

GO:0005887

integral component of plasma membrane

sp|P48039|MTR1A_HUMAN
Melatonin receptor type 1A
Search

MTNR1A

0.97	Melatonin receptor

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.56	GO:0030828	positive regulation of cGMP biosynthetic process
0.45	GO:0007623	circadian rhythm
0.37	GO:0045820	negative regulation of glycolytic process
0.36	GO:0046325	negative regulation of glucose import
0.35	GO:0007617	mating behavior
0.34	GO:0046676	negative regulation of insulin secretion
0.33	GO:0043010	camera-type eye development
0.33	GO:0007568	aging

0.85	GO:0008502	melatonin receptor activity
0.54	GO:0042562	hormone binding
0.37	GO:0097159	organic cyclic compound binding
0.35	GO:0033218	amide binding
0.33	GO:0005515	protein binding
0.33	GO:0008144	drug binding
0.32	GO:1901363	heterocyclic compound binding

0.51	GO:0043235	receptor complex
0.46	GO:0005887	integral component of plasma membrane
0.33	GO:0043025	neuronal cell body

sp|P48047|ATPO_HUMAN
ATP synthase subunit O, mitochondrial
Search

ATP5O

0.90	Mitochondrial ATP synthase O subunit

0.70	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.70	GO:0006754	ATP biosynthetic process
0.69	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.42	GO:0006839	mitochondrial transport
0.40	GO:0046907	intracellular transport
0.37	GO:0042407	cristae formation

0.71	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
0.38	GO:0005496	steroid binding
0.37	GO:0032403	protein complex binding
0.36	GO:0008144	drug binding
0.35	GO:0008553	proton-exporting ATPase activity, phosphorylative mechanism

0.49	GO:0005753	mitochondrial proton-transporting ATP synthase complex
0.45	GO:0043209	myelin sheath
0.39	GO:0031012	extracellular matrix
0.39	GO:0070062	extracellular exosome
0.37	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)
0.37	GO:0005886	plasma membrane
0.35	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.35

EC:3.6.3.6

GO:0008553

sp|P48048|KCNJ1_HUMAN
ATP-sensitive inward rectifier potassium channel 1
Search

KCNJ1

0.97	LOW QUALITY PROTEIN: ATP-sensitive inward rectifier potassium channel 1

0.78	GO:0034765	regulation of ion transmembrane transport
0.71	GO:0006813	potassium ion transport
0.61	GO:0098655	cation transmembrane transport
0.42	GO:0098660	inorganic ion transmembrane transport
0.38	GO:0070294	renal sodium ion absorption
0.37	GO:0043266	regulation of potassium ion transport
0.36	GO:0001894	tissue homeostasis
0.36	GO:0022898	regulation of transmembrane transporter activity
0.36	GO:0001822	kidney development
0.36	GO:0072358	cardiovascular system development

0.84	GO:0005242	inward rectifier potassium channel activity
0.56	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.34	GO:0042277	peptide binding
0.34	GO:0030955	potassium ion binding
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.44	GO:0005887	integral component of plasma membrane
0.34	GO:0034705	potassium channel complex

sp|P48050|KCNJ4_HUMAN
Inward rectifier potassium channel 4
Search

KCNJ4

0.93	Inward rectifier potassium channel 4

0.74	GO:0034765	regulation of ion transmembrane transport
0.68	GO:0006813	potassium ion transport
0.59	GO:0098655	cation transmembrane transport
0.36	GO:0098660	inorganic ion transmembrane transport
0.36	GO:0061337	cardiac conduction
0.36	GO:0071260	cellular response to mechanical stimulus
0.35	GO:0051289	protein homotetramerization

0.79	GO:0005242	inward rectifier potassium channel activity
0.45	GO:0030165	PDZ domain binding

0.44	GO:0016323	basolateral plasma membrane
0.40	GO:0045211	postsynaptic membrane
0.39	GO:0030659	cytoplasmic vesicle membrane
0.39	GO:0030054	cell junction
0.37	GO:0005887	integral component of plasma membrane
0.35	GO:0043025	neuronal cell body
0.35	GO:0030425	dendrite
0.35	GO:0034705	potassium channel complex

sp|P48051|KCNJ6_HUMAN
G protein-activated inward rectifier potassium channel 2
Search

KCNJ6

0.97	G protein-activated inward rectifier potassium channel 2

0.78	GO:0034765	regulation of ion transmembrane transport
0.71	GO:0006813	potassium ion transport
0.61	GO:0098655	cation transmembrane transport
0.41	GO:0098660	inorganic ion transmembrane transport
0.38	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential
0.37	GO:0086091	regulation of heart rate by cardiac conduction
0.37	GO:0098739	import across plasma membrane
0.35	GO:0071315	cellular response to morphine
0.35	GO:0051602	response to electrical stimulus

0.86	GO:0015467	G-protein activated inward rectifier potassium channel activity
0.38	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
0.35	GO:0001965	G-protein alpha-subunit binding

0.43	GO:0005887	integral component of plasma membrane
0.37	GO:0034705	potassium channel complex
0.35	GO:0032809	neuronal cell body membrane
0.35	GO:0005794	Golgi apparatus
0.34	GO:0030425	dendrite
0.34	GO:0030424	axon
0.34	GO:0009986	cell surface

sp|P48052|CBPA2_HUMAN
Carboxypeptidase A2
Search

CPA2

0.84	Carboxypeptidase A2 isoform A

0.61	GO:0006508	proteolysis
0.36	GO:0007039	protein catabolic process in the vacuole

0.78	GO:0004181	metallocarboxypeptidase activity
0.63	GO:0008270	zinc ion binding
0.34	GO:0005515	protein binding

0.50	GO:0005576	extracellular region
0.34	GO:0005773	vacuole
0.30	GO:0016020	membrane

0.78

EC:3.4.17

GO:0004181

sp|P48058|GRIA4_HUMAN
Glutamate receptor 4
Search

GRIA4

0.95	Glutamate ionotropic receptor AMPA type subunit 4

0.78	GO:0060079	excitatory postsynaptic potential
0.75	GO:0035235	ionotropic glutamate receptor signaling pathway
0.59	GO:0034220	ion transmembrane transport
0.35	GO:0051968	positive regulation of synaptic transmission, glutamatergic
0.35	GO:0060992	response to fungicide
0.35	GO:0050803	regulation of synapse structure or activity

0.80	GO:0005234	extracellularly glutamate-gated ion channel activity
0.76	GO:0004970	ionotropic glutamate receptor activity
0.55	GO:0099094	ligand-gated cation channel activity
0.34	GO:0005515	protein binding
0.33	GO:0008897	holo-[acyl-carrier-protein] synthase activity
0.32	GO:0000287	magnesium ion binding

0.77	GO:0045211	postsynaptic membrane
0.73	GO:0030054	cell junction
0.47	GO:0032281	AMPA glutamate receptor complex
0.41	GO:0030425	dendrite
0.40	GO:0043025	neuronal cell body
0.39	GO:0032983	kainate selective glutamate receptor complex
0.37	GO:0044309	neuron spine
0.36	GO:1903561	extracellular vesicle
0.35	GO:0043195	terminal bouton
0.35	GO:0030666	endocytic vesicle membrane

0.33

EC:2.7.8.7

GO:0008897

sp|P48059|LIMS1_HUMAN
LIM and senescent cell antigen-like-containing domain protein 1
Search

LIMS1

0.79	LIM and senescent cell antigen-like-containing domain protein 1

0.64	GO:0045216	cell-cell junction organization
0.52	GO:0051894	positive regulation of focal adhesion assembly
0.51	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
0.51	GO:1901224	positive regulation of NIK/NF-kappaB signaling
0.51	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.49	GO:0071560	cellular response to transforming growth factor beta stimulus
0.47	GO:0043547	positive regulation of GTPase activity
0.46	GO:0010628	positive regulation of gene expression
0.45	GO:0045892	negative regulation of transcription, DNA-templated
0.43	GO:0045184	establishment of protein localization

0.54	GO:0046872	metal ion binding
0.48	GO:0019901	protein kinase binding
0.35	GO:0019904	protein domain specific binding
0.34	GO:0120013	intermembrane lipid transfer activity

0.65	GO:0005925	focal adhesion
0.48	GO:0048471	perinuclear region of cytoplasm
0.48	GO:0005911	cell-cell junction
0.47	GO:0005886	plasma membrane
0.37	GO:0030018	Z disc
0.35	GO:0043234	protein complex
0.33	GO:0005829	cytosol

sp|P48060|GLIP1_HUMAN
Glioma pathogenesis-related protein 1
Search

GLIPR1

0.97	Glioma pathogenesis-related protein 1

0.37	GO:0043312	neutrophil degranulation
0.35	GO:0019216	regulation of lipid metabolic process
0.34	GO:0007229	integrin-mediated signaling pathway
0.33	GO:0010466	negative regulation of peptidase activity

0.33	GO:0030414	peptidase inhibitor activity
0.32	GO:0046872	metal ion binding

0.66	GO:0005576	extracellular region
0.37	GO:0035577	azurophil granule membrane
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P48061|SDF1_HUMAN
Stromal cell-derived factor 1
Search

CXCL12

0.94	C-X-C motif chemokine ligand 12

0.82	GO:0060326	cell chemotaxis
0.74	GO:0006955	immune response
0.72	GO:1903237	negative regulation of leukocyte tethering or rolling
0.71	GO:2000669	negative regulation of dendritic cell apoptotic process
0.70	GO:0006952	defense response
0.69	GO:2000406	positive regulation of T cell migration
0.69	GO:0090026	positive regulation of monocyte chemotaxis
0.69	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
0.67	GO:0070098	chemokine-mediated signaling pathway
0.61	GO:0045785	positive regulation of cell adhesion

0.84	GO:0008009	chemokine activity
0.71	GO:0045236	CXCR chemokine receptor binding
0.50	GO:0042056	chemoattractant activity

0.66	GO:0005576	extracellular region
0.50	GO:0009897	external side of plasma membrane
0.40	GO:0031982	vesicle
0.35	GO:0005737	cytoplasm

sp|P48065|S6A12_HUMAN
Sodium- and chloride-dependent betaine transporter
Search

SLC6A12

0.47	Sodium- and chloride-dependent betaine transporter

0.75	GO:0015812	gamma-aminobutyric acid transport
0.54	GO:0055085	transmembrane transport
0.36	GO:0009992	cellular water homeostasis
0.35	GO:0071474	cellular hyperosmotic response
0.34	GO:0010033	response to organic substance
0.34	GO:0032259	methylation

0.79	GO:0005332	gamma-aminobutyric acid:sodium symporter activity
0.34	GO:0008168	methyltransferase activity
0.33	GO:0005515	protein binding
0.33	GO:0046872	metal ion binding
0.33	GO:0003677	DNA binding

0.60	GO:0005887	integral component of plasma membrane
0.33	GO:0005634	nucleus

0.34

GO:0008168

sp|P48066|S6A11_HUMAN
Sodium- and chloride-dependent GABA transporter 3
Search

SLC6A11

0.44	Sodium- and chloride-dependent GABA transporter 3

0.76	GO:0006836	neurotransmitter transport
0.61	GO:0015718	monocarboxylic acid transport
0.57	GO:0006865	amino acid transport
0.55	GO:0055085	transmembrane transport
0.37	GO:0007420	brain development
0.36	GO:0042493	response to drug
0.32	GO:0006812	cation transport

0.79	GO:0005328	neurotransmitter:sodium symporter activity
0.68	GO:0015185	gamma-aminobutyric acid transmembrane transporter activity
0.68	GO:0015355	secondary active monocarboxylate transmembrane transporter activity
0.63	GO:0005283	sodium:amino acid symporter activity
0.62	GO:0015296	anion:cation symporter activity
0.38	GO:0042165	neurotransmitter binding
0.34	GO:0015193	L-proline transmembrane transporter activity

0.56	GO:0005887	integral component of plasma membrane
0.36	GO:0042995	cell projection
0.33	GO:0005737	cytoplasm

sp|P48067|SC6A9_HUMAN
Sodium- and chloride-dependent glycine transporter 1
Search

SLC6A9

0.56	Solute carrier family 6 (neurotransmitter transporter, glycine), member 9

0.76	GO:0006836	neurotransmitter transport
0.69	GO:0003333	amino acid transmembrane transport
0.53	GO:0060092	regulation of synaptic transmission, glycinergic
0.53	GO:0015807	L-amino acid transport
0.52	GO:0007268	chemical synaptic transmission
0.52	GO:0015804	neutral amino acid transport
0.49	GO:0015893	drug transport
0.48	GO:0007626	locomotory behavior
0.47	GO:0060078	regulation of postsynaptic membrane potential
0.46	GO:0099643	signal release from synapse

0.79	GO:0005328	neurotransmitter:sodium symporter activity
0.73	GO:0005283	sodium:amino acid symporter activity
0.57	GO:0015187	glycine transmembrane transporter activity

0.63	GO:0005887	integral component of plasma membrane
0.51	GO:0044456	synapse part
0.44	GO:0097458	neuron part

sp|P48145|NPBW1_HUMAN
Neuropeptides B/W receptor type 1
Search

NPBWR1

0.97	Neuropeptides B and W receptor 1

0.77	GO:0007218	neuropeptide signaling pathway
0.50	GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
0.49	GO:0007268	chemical synaptic transmission
0.47	GO:0038169	somatostatin receptor signaling pathway
0.44	GO:0009755	hormone-mediated signaling pathway
0.42	GO:0019222	regulation of metabolic process
0.41	GO:0038003	opioid receptor signaling pathway
0.35	GO:0051339	regulation of lyase activity
0.35	GO:0031279	regulation of cyclase activity
0.34	GO:0051338	regulation of transferase activity

0.81	GO:0008188	neuropeptide receptor activity
0.53	GO:0042923	neuropeptide binding
0.41	GO:0004985	opioid receptor activity
0.36	GO:0005515	protein binding
0.33	GO:0008502	melatonin receptor activity
0.33	GO:0060182	apelin receptor activity
0.33	GO:0045028	G-protein coupled purinergic nucleotide receptor activity
0.32	GO:0044212	transcription regulatory region DNA binding
0.31	GO:0003700	DNA binding transcription factor activity

0.49	GO:0043005	neuron projection
0.45	GO:0005887	integral component of plasma membrane
0.33	GO:0015629	actin cytoskeleton

sp|P48146|NPBW2_HUMAN
Neuropeptides B/W receptor type 2
Search

NPBWR2

0.97	Neuropeptides B and W receptor 2

0.76	GO:0007218	neuropeptide signaling pathway
0.50	GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
0.48	GO:0007268	chemical synaptic transmission
0.43	GO:0038169	somatostatin receptor signaling pathway
0.42	GO:0038003	opioid receptor signaling pathway
0.41	GO:0071310	cellular response to organic substance
0.40	GO:0019222	regulation of metabolic process
0.40	GO:0009725	response to hormone
0.40	GO:0071495	cellular response to endogenous stimulus
0.38	GO:0023051	regulation of signaling

0.79	GO:0008188	neuropeptide receptor activity
0.53	GO:0042923	neuropeptide binding
0.42	GO:0004985	opioid receptor activity
0.40	GO:0030273	melanin-concentrating hormone receptor activity
0.36	GO:0005515	protein binding
0.36	GO:0004950	chemokine receptor activity
0.33	GO:0005044	scavenger receptor activity
0.33	GO:0060182	apelin receptor activity
0.32	GO:0004427	inorganic diphosphatase activity
0.31	GO:0000287	magnesium ion binding

0.48	GO:0043005	neuron projection
0.45	GO:0031226	intrinsic component of plasma membrane
0.33	GO:0009897	external side of plasma membrane
0.32	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.32	EC:3.6.1.1	GO:0004427
0.32	KEGG:R00004	GO:0004427

sp|P48147|PPCE_HUMAN
Prolyl endopeptidase
Search

PREP

0.66	Prolyl endopeptidase

0.59

GO:0006508

proteolysis

0.71	GO:0070008	serine-type exopeptidase activity
0.67	GO:0004252	serine-type endopeptidase activity
0.35	GO:0042277	peptide binding
0.33	GO:0008234	cysteine-type peptidase activity
0.33	GO:0005515	protein binding

0.49	GO:0005829	cytosol
0.44	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.71

GO:0070008

sp|P48163|MAOX_HUMAN
NADP-dependent malic enzyme
Search

ME1

0.53	NADP-dependent malic enzyme

0.58	GO:1902031	regulation of NADP metabolic process
0.56	GO:0006108	malate metabolic process
0.53	GO:0051262	protein tetramerization
0.52	GO:0055114	oxidation-reduction process
0.44	GO:0006090	pyruvate metabolic process
0.38	GO:0009725	response to hormone
0.35	GO:0009743	response to carbohydrate
0.35	GO:0019216	regulation of lipid metabolic process
0.34	GO:0006741	NADP biosynthetic process
0.33	GO:0005975	carbohydrate metabolic process

0.78	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity
0.67	GO:0051287	NAD binding
0.59	GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity
0.53	GO:0046872	metal ion binding
0.40	GO:0008948	oxaloacetate decarboxylase activity
0.35	GO:0050661	NADP binding
0.34	GO:0043531	ADP binding
0.33	GO:0009055	electron transfer activity
0.33	GO:0005515	protein binding

0.46	GO:0005739	mitochondrion
0.37	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.78	EC:1.1.1.38 EC:1.1.1.39	GO:0004471
0.78	KEGG:R00214	GO:0004471

sp|P48165|CXA8_HUMAN
Gap junction alpha-8 protein
Search

GJA8

0.64	Gap junction alpha-8 protein (Fragment)

0.60	GO:0007154	cell communication
0.57	GO:0002088	lens development in camera-type eye
0.49	GO:0007601	visual perception
0.41	GO:0051260	protein homooligomerization
0.41	GO:0055085	transmembrane transport
0.41	GO:0048050	post-embryonic eye morphogenesis
0.40	GO:0003161	cardiac conduction system development
0.40	GO:0055008	cardiac muscle tissue morphogenesis
0.39	GO:0008016	regulation of heart contraction
0.37	GO:0023052	signaling

0.57	GO:0005243	gap junction channel activity
0.34	GO:0005515	protein binding

0.84	GO:0005922	connexin complex
0.35	GO:0005887	integral component of plasma membrane

sp|P48167|GLRB_HUMAN
Glycine receptor subunit beta
Search

GLRB

0.97	Glycine receptor subunit beta

0.77	GO:0060079	excitatory postsynaptic potential
0.75	GO:1902476	chloride transmembrane transport
0.61	GO:0060012	synaptic transmission, glycinergic
0.60	GO:0097112	gamma-aminobutyric acid receptor clustering
0.59	GO:0060013	righting reflex
0.58	GO:0001964	startle response
0.57	GO:0007628	adult walking behavior
0.57	GO:0007340	acrosome reaction
0.56	GO:0007218	neuropeptide signaling pathway
0.53	GO:0007601	visual perception

0.85	GO:0016934	extracellularly glycine-gated chloride channel activity
0.68	GO:0099600	transmembrane receptor activity
0.63	GO:0038023	signaling receptor activity
0.60	GO:0016594	glycine binding
0.35	GO:0005515	protein binding

0.77	GO:0045211	postsynaptic membrane
0.61	GO:0016935	glycine-gated chloride channel complex
0.60	GO:0098982	GABA-ergic synapse
0.39	GO:0030425	dendrite
0.38	GO:0030054	cell junction
0.35	GO:0043204	perikaryon
0.35	GO:0009897	external side of plasma membrane
0.34	GO:0005783	endoplasmic reticulum

sp|P48169|GBRA4_HUMAN
Gamma-aminobutyric acid receptor subunit alpha-4
Search

GABRA4

0.97	LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit alpha-4

0.81	GO:0007214	gamma-aminobutyric acid signaling pathway
0.72	GO:0006821	chloride transport
0.60	GO:0034220	ion transmembrane transport
0.60	GO:2001023	regulation of response to drug
0.57	GO:0007417	central nervous system development

0.84	GO:0004890	GABA-A receptor activity
0.76	GO:0005230	extracellular ligand-gated ion channel activity
0.40	GO:0005254	chloride channel activity
0.37	GO:0008503	benzodiazepine receptor activity

0.55	GO:0005886	plasma membrane
0.52	GO:1902711	GABA-A receptor complex
0.41	GO:0034707	chloride channel complex
0.40	GO:0098794	postsynapse
0.39	GO:0030054	cell junction

sp|P48200|IREB2_HUMAN
Iron-responsive element-binding protein 2
Search

IREB2

0.97	Iron-responsive element-binding protein 2

0.72	GO:0006879	cellular iron ion homeostasis
0.72	GO:0017148	negative regulation of translation
0.57	GO:0050892	intestinal absorption
0.57	GO:0030316	osteoclast differentiation
0.55	GO:0034101	erythrocyte homeostasis
0.52	GO:0009791	post-embryonic development
0.50	GO:0006782	protoporphyrinogen IX biosynthetic process
0.40	GO:0010040	response to iron(II) ion
0.37	GO:0072705	cellular response to mercaptoethanol
0.37	GO:1904373	response to kainic acid

0.85	GO:0030350	iron-responsive element binding
0.81	GO:0030371	translation repressor activity
0.61	GO:0051539	4 iron, 4 sulfur cluster binding
0.37	GO:0003994	aconitate hydratase activity
0.36	GO:0001069	regulatory region RNA binding
0.36	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.48	GO:0005829	cytosol
0.44	GO:0005739	mitochondrion
0.35	GO:0043025	neuronal cell body
0.35	GO:0030424	axon
0.34	GO:0005794	Golgi apparatus
0.34	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane

0.37

EC:4.2.1.3

GO:0003994

sp|P48201|AT5G3_HUMAN
ATP synthase F(0) complex subunit C3, mitochondrial
Search

0.86	ATP synthase lipid-binding protein, mitochondrial

0.76	GO:0015991	ATP hydrolysis coupled proton transport
0.70	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.70	GO:0006754	ATP biosynthetic process
0.38	GO:0045471	response to ethanol
0.37	GO:0042407	cristae formation
0.36	GO:0006839	mitochondrial transport
0.35	GO:0046907	intracellular transport
0.35	GO:0007568	aging
0.34	GO:0006357	regulation of transcription by RNA polymerase II
0.33	GO:0055114	oxidation-reduction process

0.71	GO:0008289	lipid binding
0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.45	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
0.45	GO:0019829	cation-transporting ATPase activity
0.35	GO:0004450	isocitrate dehydrogenase (NADP+) activity
0.35	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
0.33	GO:0003700	DNA binding transcription factor activity
0.33	GO:0005515	protein binding
0.32	GO:0003676	nucleic acid binding

0.72	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)
0.47	GO:0005753	mitochondrial proton-transporting ATP synthase complex
0.35	GO:0005741	mitochondrial outer membrane
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.35

EC:1.1.1.42

GO:0004450

sp|P48230|T4S4_HUMAN
Transmembrane 4 L6 family member 4
Search

TM4SF4

0.89	Transmembrane 4 L six family member 4

0.49	GO:2000077	negative regulation of type B pancreatic cell development
0.48	GO:2000227	negative regulation of pancreatic A cell differentiation
0.48	GO:0090104	pancreatic epsilon cell differentiation
0.36	GO:0042246	tissue regeneration
0.34	GO:0006825	copper ion transport
0.34	GO:0006879	cellular iron ion homeostasis
0.32	GO:0055114	oxidation-reduction process

0.34	GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor
0.34	GO:0005507	copper ion binding
0.30	GO:0005515	protein binding

0.35

GO:0005887

integral component of plasma membrane

0.34

EC:1.16.3

GO:0016724

sp|P48304|REG1B_HUMAN
Lithostathine-1-beta
Search

0.96	Regenerating islet-derived protein 3-gamma

0.56	GO:0010469	regulation of receptor activity
0.55	GO:0044278	cell wall disruption in other organism
0.54	GO:1904697	regulation of acinar cell proliferation
0.54	GO:1990867	response to gastrin
0.54	GO:1990864	response to growth hormone-releasing hormone
0.53	GO:1903492	response to acetylsalicylate
0.53	GO:0008284	positive regulation of cell proliferation
0.52	GO:1990785	response to water-immersion restraint stress
0.52	GO:0019730	antimicrobial humoral response
0.52	GO:0001967	suckling behavior

0.60	GO:0030246	carbohydrate binding
0.57	GO:0008083	growth factor activity
0.56	GO:0005539	glycosaminoglycan binding
0.52	GO:0042802	identical protein binding
0.50	GO:0001871	pattern binding
0.48	GO:0019903	protein phosphatase binding
0.46	GO:1901681	sulfur compound binding
0.43	GO:0046983	protein dimerization activity
0.39	GO:0043168	anion binding
0.36	GO:0004421	hydroxymethylglutaryl-CoA synthase activity

0.51	GO:0005615	extracellular space
0.50	GO:0042588	zymogen granule
0.50	GO:0032809	neuronal cell body membrane
0.50	GO:0032590	dendrite membrane
0.49	GO:0045178	basal part of cell
0.48	GO:1903561	extracellular vesicle
0.48	GO:0030426	growth cone
0.46	GO:0048471	perinuclear region of cytoplasm
0.43	GO:0005829	cytosol
0.40	GO:0043234	protein complex

0.36	EC:2.3.3.10	GO:0004421
0.36	KEGG:R01978	GO:0004421

sp|P48307|TFPI2_HUMAN
Tissue factor pathway inhibitor 2
Search

TFPI2

0.84	Tissue factor pathway inhibitor

0.76	GO:0010951	negative regulation of endopeptidase activity
0.65	GO:0007596	blood coagulation
0.42	GO:0071498	cellular response to fluid shear stress
0.39	GO:0006508	proteolysis
0.38	GO:0006030	chitin metabolic process
0.36	GO:0055002	striated muscle cell development
0.35	GO:0031032	actomyosin structure organization
0.35	GO:0010927	cellular component assembly involved in morphogenesis
0.35	GO:1903706	regulation of hemopoiesis
0.35	GO:0048731	system development

0.79	GO:0004867	serine-type endopeptidase inhibitor activity
0.40	GO:0008233	peptidase activity
0.38	GO:0008061	chitin binding
0.38	GO:0005201	extracellular matrix structural constituent
0.34	GO:0050431	transforming growth factor beta binding
0.34	GO:0048019	receptor antagonist activity
0.33	GO:0005516	calmodulin binding
0.33	GO:0008191	metalloendopeptidase inhibitor activity
0.32	GO:0090729	toxin activity
0.32	GO:0004713	protein tyrosine kinase activity

0.61	GO:0005576	extracellular region
0.31	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.40

GO:0008233

sp|P48357|LEPR_HUMAN
Leptin receptor
Search

LEPR

0.95	Transmembrane leptin receptor

0.86	GO:0033210	leptin-mediated signaling pathway
0.58	GO:0001525	angiogenesis
0.58	GO:2000505	regulation of energy homeostasis
0.58	GO:0097009	energy homeostasis
0.58	GO:0098868	bone growth
0.58	GO:0060259	regulation of feeding behavior
0.57	GO:0046850	regulation of bone remodeling
0.56	GO:0030217	T cell differentiation
0.55	GO:0006909	phagocytosis
0.55	GO:0010507	negative regulation of autophagy

0.86	GO:0038021	leptin receptor activity
0.53	GO:0042802	identical protein binding
0.35	GO:0017046	peptide hormone binding

0.56	GO:0043235	receptor complex
0.41	GO:0016323	basolateral plasma membrane
0.35	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

sp|P48378|RFX2_HUMAN
DNA-binding protein RFX2
Search

RFX2

0.93	Regulatory factor X, 2 (Influences HLA class II expression)

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0001675	acrosome assembly
0.54	GO:0060271	cilium assembly
0.53	GO:1990830	cellular response to leukemia inhibitory factor
0.52	GO:0007368	determination of left/right symmetry
0.50	GO:1902680	positive regulation of RNA biosynthetic process
0.50	GO:0070121	Kupffer's vesicle development
0.44	GO:0072560	type B pancreatic cell maturation

0.55	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.46	GO:0003700	DNA binding transcription factor activity
0.36	GO:0004435	phosphatidylinositol phospholipase C activity

0.61	GO:0005634	nucleus
0.39	GO:0000785	chromatin
0.38	GO:0043233	organelle lumen
0.30	GO:0016020	membrane

0.36	EC:3.1.4.11	GO:0004435
0.36	KEGG:R03435	GO:0004435

sp|P48380|RFX3_HUMAN
Transcription factor RFX3
Search

RFX3

0.93	Regulatory factor X, 3 (influences HLA class II expression)

0.68	GO:0072560	type B pancreatic cell maturation
0.67	GO:2000078	positive regulation of type B pancreatic cell development
0.65	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry
0.63	GO:0060285	cilium-dependent cell motility
0.61	GO:0050796	regulation of insulin secretion
0.60	GO:0060271	cilium assembly
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:0010468	regulation of gene expression
0.56	GO:1902680	positive regulation of RNA biosynthetic process

0.60	GO:0044212	transcription regulatory region DNA binding
0.52	GO:0043565	sequence-specific DNA binding
0.50	GO:0003700	DNA binding transcription factor activity
0.48	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.55	GO:0000785	chromatin
0.52	GO:0031974	membrane-enclosed lumen

sp|P48382|RFX5_HUMAN
DNA-binding protein RFX5
Search

RFX5

0.94	Regulatory factor X, 5

0.66	GO:0006357	regulation of transcription by RNA polymerase II
0.57	GO:0045893	positive regulation of transcription, DNA-templated
0.56	GO:0045892	negative regulation of transcription, DNA-templated

0.55	GO:0003677	DNA binding
0.52	GO:0001067	regulatory region nucleic acid binding
0.45	GO:0003700	DNA binding transcription factor activity

0.58

GO:0005634

nucleus

sp|P48426|PI42A_HUMAN
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Search

PIP4K2A

0.93	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

0.75	GO:0046854	phosphatidylinositol phosphorylation
0.63	GO:2000786	positive regulation of autophagosome assembly
0.57	GO:0035855	megakaryocyte development
0.41	GO:0048634	regulation of muscle organ development
0.36	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling
0.35	GO:0006661	phosphatidylinositol biosynthetic process
0.33	GO:0007166	cell surface receptor signaling pathway

0.82	GO:0016307	phosphatidylinositol phosphate kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0042803	protein homodimerization activity
0.34	GO:0005057	signal transducer activity, downstream of receptor

0.59	GO:0005776	autophagosome
0.43	GO:0005654	nucleoplasm
0.36	GO:0005886	plasma membrane
0.35	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0005829	cytosol

0.82

GO:0016307

sp|P48431|SOX2_HUMAN
Transcription factor SOX-2
Search

SOX2

0.96	Sex determining region Y-box 2

0.59	GO:0021536	diencephalon development
0.59	GO:0035270	endocrine system development
0.58	GO:0001714	endodermal cell fate specification
0.57	GO:0048839	inner ear development
0.57	GO:0048732	gland development
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0001654	eye development
0.56	GO:0035019	somatic stem cell population maintenance

0.56	GO:0035198	miRNA binding
0.55	GO:0003677	DNA binding
0.51	GO:0001067	regulatory region nucleic acid binding
0.47	GO:0003700	DNA binding transcription factor activity
0.44	GO:0003682	chromatin binding
0.36	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.47	GO:0005829	cytosol
0.47	GO:0070013	intracellular organelle lumen
0.43	GO:0044446	intracellular organelle part
0.38	GO:0005667	transcription factor complex

sp|P48436|SOX9_HUMAN
Transcription factor SOX-9
Search

SOX9

0.94	SRY sex determining region Y-box 9

0.71	GO:0006357	regulation of transcription by RNA polymerase II
0.65	GO:0060767	epithelial cell proliferation involved in prostate gland development
0.64	GO:0060784	regulation of cell proliferation involved in tissue homeostasis
0.64	GO:0060516	primary prostatic bud elongation
0.64	GO:2000741	positive regulation of mesenchymal stem cell differentiation
0.64	GO:0072289	metanephric nephron tubule formation
0.64	GO:0019100	male germ-line sex determination
0.64	GO:0060221	retinal rod cell differentiation
0.64	GO:0071504	cellular response to heparin
0.64	GO:0072034	renal vesicle induction

0.73	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.60	GO:0035326	enhancer binding
0.59	GO:0001046	core promoter sequence-specific DNA binding
0.58	GO:0097157	pre-mRNA intronic binding
0.58	GO:0034236	protein kinase A catalytic subunit binding
0.56	GO:0003682	chromatin binding
0.55	GO:0008013	beta-catenin binding
0.50	GO:0046982	protein heterodimerization activity
0.48	GO:0004672	protein kinase activity
0.41	GO:0043425	bHLH transcription factor binding

0.61	GO:0005634	nucleus
0.51	GO:0005667	transcription factor complex
0.47	GO:0070013	intracellular organelle lumen
0.43	GO:0044446	intracellular organelle part
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|P48443|RXRG_HUMAN
Retinoic acid receptor RXR-gamma
Search

RXRG

0.89	Retinoid X receptor gamma

0.79	GO:0043401	steroid hormone mediated signaling pathway
0.66	GO:0048384	retinoic acid receptor signaling pathway
0.65	GO:0051289	protein homotetramerization
0.64	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
0.58	GO:0006351	transcription, DNA-templated
0.46	GO:0035357	peroxisome proliferator activated receptor signaling pathway
0.45	GO:0032526	response to retinoic acid
0.43	GO:0045994	positive regulation of translational initiation by iron
0.43	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
0.43	GO:0060687	regulation of branching involved in prostate gland morphogenesis

0.80	GO:0003707	steroid hormone receptor activity
0.69	GO:0004886	9-cis retinoic acid receptor activity
0.64	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.60	GO:0001012	RNA polymerase II regulatory region DNA binding
0.56	GO:0003690	double-stranded DNA binding
0.47	GO:0050692	DBD domain binding
0.46	GO:0050693	LBD domain binding
0.46	GO:0042809	vitamin D receptor binding
0.46	GO:0001972	retinoic acid binding

0.61	GO:0005634	nucleus
0.43	GO:0043235	receptor complex
0.42	GO:0005667	transcription factor complex
0.41	GO:0000785	chromatin
0.40	GO:0043233	organelle lumen

sp|P48444|COPD_HUMAN
Coatomer subunit delta
Search

ARCN1

0.68	Coatomer subunit delta

0.81	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.65	GO:0015031	protein transport
0.56	GO:0021691	cerebellar Purkinje cell layer maturation
0.52	GO:0008344	adult locomotory behavior
0.52	GO:0043473	pigmentation
0.35	GO:0006891	intra-Golgi vesicle-mediated transport
0.34	GO:0006888	ER to Golgi vesicle-mediated transport
0.34	GO:0034613	cellular protein localization

0.34	GO:0003723	RNA binding
0.33	GO:0005515	protein binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.81	GO:0030126	COPI vesicle coat
0.73	GO:0000139	Golgi membrane
0.46	GO:0005783	endoplasmic reticulum
0.34	GO:0030133	transport vesicle
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.34	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|P48448|AL3B2_HUMAN
Aldehyde dehydrogenase family 3 member B2
Search

ALDH3B1

0.42	Aldehyde dehydrogenase

0.64	GO:0006081	cellular aldehyde metabolic process
0.52	GO:0055114	oxidation-reduction process
0.47	GO:0034599	cellular response to oxidative stress
0.43	GO:0006068	ethanol catabolic process
0.37	GO:0030148	sphingolipid biosynthetic process
0.35	GO:0043312	neutrophil degranulation

0.74	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
0.49	GO:0004029	aldehyde dehydrogenase (NAD) activity
0.39	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity
0.34	GO:0008106	alcohol dehydrogenase (NADP+) activity
0.34	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
0.33	GO:0016788	hydrolase activity, acting on ester bonds
0.33	GO:0005515	protein binding

0.44	GO:0005829	cytosol
0.40	GO:0005886	plasma membrane
0.37	GO:0005811	lipid droplet
0.36	GO:0070062	extracellular exosome
0.36	GO:0035579	specific granule membrane
0.33	GO:0005783	endoplasmic reticulum
0.30	GO:0031224	intrinsic component of membrane

0.74

EC:1.2.1.5

GO:0004030

sp|P48449|ERG7_HUMAN
Lanosterol synthase
Search

LSS

0.69	Terpene cyclase/mutase family member

0.55	GO:0006695	cholesterol biosynthetic process
0.52	GO:0031647	regulation of protein stability

0.66

GO:0016866

intramolecular transferase activity

0.53	GO:0005811	lipid droplet
0.30	GO:0031224	intrinsic component of membrane

0.66

EC:5.4

GO:0016866

sp|P48454|PP2BC_HUMAN
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Search

PPP3CC

0.50	Serine/threonine-protein phosphatase

0.71	GO:0006470	protein dephosphorylation
0.40	GO:0007399	nervous system development
0.40	GO:0048513	animal organ development
0.40	GO:1905205	positive regulation of connective tissue replacement
0.39	GO:1903244	positive regulation of cardiac muscle hypertrophy in response to stress
0.39	GO:0051533	positive regulation of NFAT protein import into nucleus
0.39	GO:0014883	transition between fast and slow fiber
0.39	GO:0035562	negative regulation of chromatin binding
0.39	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA
0.39	GO:0003299	muscle hypertrophy in response to stress

0.71	GO:0004721	phosphoprotein phosphatase activity
0.39	GO:0016018	cyclosporin A binding
0.39	GO:0005516	calmodulin binding
0.36	GO:0019899	enzyme binding
0.36	GO:0046983	protein dimerization activity
0.34	GO:0019855	calcium channel inhibitor activity
0.33	GO:0046872	metal ion binding
0.33	GO:0046873	metal ion transmembrane transporter activity
0.32	GO:0003676	nucleic acid binding

0.39	GO:0005955	calcineurin complex
0.38	GO:0030018	Z disc
0.37	GO:0098794	postsynapse
0.37	GO:0070062	extracellular exosome
0.37	GO:0005829	cytosol
0.36	GO:0005654	nucleoplasm
0.35	GO:0005739	mitochondrion
0.34	GO:0042383	sarcolemma
0.34	GO:0043204	perikaryon
0.33	GO:0030424	axon

0.71

EC:3.1.3.16

GO:0004721

sp|P48506|GSH1_HUMAN
Glutamate--cysteine ligase catalytic subunit
Search

GCLC

0.80	Glutamate--cysteine ligase catalytic subunit

0.77	GO:0006750	glutathione biosynthetic process
0.59	GO:0051900	regulation of mitochondrial depolarization
0.58	GO:0008637	apoptotic mitochondrial changes
0.57	GO:0019852	L-ascorbic acid metabolic process
0.57	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
0.57	GO:0031397	negative regulation of protein ubiquitination
0.57	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.55	GO:0050880	regulation of blood vessel size
0.55	GO:0046685	response to arsenic-containing substance
0.53	GO:0009410	response to xenobiotic stimulus

0.78	GO:0004357	glutamate-cysteine ligase activity
0.61	GO:0016595	glutamate binding
0.52	GO:0043531	ADP binding
0.52	GO:0046982	protein heterodimerization activity
0.47	GO:0000287	magnesium ion binding
0.45	GO:0050662	coenzyme binding
0.34	GO:0005524	ATP binding
0.33	GO:0003676	nucleic acid binding

0.62	GO:0017109	glutamate-cysteine ligase complex
0.49	GO:0005829	cytosol

0.78	EC:6.3.2.2	GO:0004357
0.78	KEGG:R00894	GO:0004357

sp|P48507|GSH0_HUMAN
Glutamate--cysteine ligase regulatory subunit
Search

GCLM

0.89	Gamma-glutamylcysteine synthetase regulatory subunit

0.78	GO:0006750	glutathione biosynthetic process
0.63	GO:0035227	regulation of glutamate-cysteine ligase activity
0.62	GO:0051351	positive regulation of ligase activity
0.59	GO:0051900	regulation of mitochondrial depolarization
0.57	GO:0008637	apoptotic mitochondrial changes
0.57	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
0.56	GO:1990830	cellular response to leukemia inhibitory factor
0.55	GO:0050880	regulation of blood vessel size
0.51	GO:0006534	cysteine metabolic process
0.51	GO:0006536	glutamate metabolic process

0.85	GO:0035226	glutamate-cysteine ligase catalytic subunit binding
0.56	GO:0016874	ligase activity
0.51	GO:0046982	protein heterodimerization activity
0.44	GO:0030234	enzyme regulator activity
0.34	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.32	GO:0016740	transferase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.62	GO:0017109	glutamate-cysteine ligase complex
0.34	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.56

EC:6

GO:0016874

sp|P48509|CD151_HUMAN
CD151 antigen
Search

CD151

0.60	Tetraspanin

0.52	GO:0042098	T cell proliferation
0.48	GO:0016477	cell migration
0.41	GO:0007166	cell surface receptor signaling pathway

0.51	GO:0005178	integrin binding
0.37	GO:0005509	calcium ion binding

0.50	GO:0005604	basement membrane
0.40	GO:0005887	integral component of plasma membrane

sp|P48539|PCP4_HUMAN
Purkinje cell protein 4
Search

PCP4

0.97	Brain-specific polypeptide PEP-19

0.62	GO:0099004	calmodulin dependent kinase signaling pathway
0.56	GO:0045666	positive regulation of neuron differentiation
0.38	GO:1904009	cellular response to monosodium glutamate
0.37	GO:0033603	positive regulation of dopamine secretion
0.36	GO:0001649	osteoblast differentiation
0.36	GO:0043524	negative regulation of neuron apoptotic process
0.36	GO:0031346	positive regulation of cell projection organization
0.36	GO:0010975	regulation of neuron projection development
0.36	GO:0006469	negative regulation of protein kinase activity
0.35	GO:0006970	response to osmotic stress

0.79	GO:0005516	calmodulin binding
0.50	GO:0005509	calcium ion binding
0.33	GO:0003723	RNA binding

0.45	GO:0043234	protein complex
0.36	GO:0005883	neurofilament
0.36	GO:0005829	cytosol
0.36	GO:0030424	axon
0.35	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P48544|KCNJ5_HUMAN
G protein-activated inward rectifier potassium channel 4
Search

KCNJ5

0.97	G protein-activated inward rectifier potassium channel 4

0.78	GO:0034765	regulation of ion transmembrane transport
0.71	GO:0006813	potassium ion transport
0.61	GO:0098655	cation transmembrane transport
0.59	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential
0.56	GO:0086091	regulation of heart rate by cardiac conduction
0.55	GO:0099587	inorganic ion import across plasma membrane
0.35	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential
0.35	GO:0071315	cellular response to morphine
0.34	GO:0051602	response to electrical stimulus

0.85	GO:0015467	G-protein activated inward rectifier potassium channel activity
0.59	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
0.35	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
0.35	GO:0005515	protein binding

0.52	GO:0008076	voltage-gated potassium channel complex
0.38	GO:0030315	T-tubule
0.37	GO:0009897	external side of plasma membrane
0.34	GO:0032809	neuronal cell body membrane
0.34	GO:0005794	Golgi apparatus
0.34	GO:0030425	dendrite
0.34	GO:0030424	axon

sp|P48546|GIPR_HUMAN
Gastric inhibitory polypeptide receptor
Search

0.96	Gastric inhibitory polypeptide receptor

0.87	GO:0038192	gastric inhibitory peptide signaling pathway
0.71	GO:0007166	cell surface receptor signaling pathway
0.69	GO:0031018	endocrine pancreas development
0.46	GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
0.46	GO:0043950	positive regulation of cAMP-mediated signaling
0.45	GO:0048678	response to axon injury
0.45	GO:0070542	response to fatty acid
0.45	GO:0032024	positive regulation of insulin secretion
0.45	GO:0051592	response to calcium ion
0.45	GO:0009749	response to glucose

0.87	GO:0016519	gastric inhibitory peptide receptor activity
0.45	GO:0017046	peptide hormone binding
0.36	GO:0005515	protein binding

0.53	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P48547|KCNC1_HUMAN
Potassium voltage-gated channel subfamily C member 1
Search

KCNC1

0.86	Myogenic factor

0.75	GO:0051260	protein homooligomerization
0.74	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.53	GO:0051262	protein tetramerization
0.40	GO:0021759	globus pallidus development
0.39	GO:0035864	response to potassium ion
0.39	GO:1990089	response to nerve growth factor
0.39	GO:0010996	response to auditory stimulus
0.39	GO:0014075	response to amine
0.38	GO:0043268	positive regulation of potassium ion transport

0.78	GO:0005249	voltage-gated potassium channel activity
0.55	GO:0019894	kinesin binding
0.55	GO:0044325	ion channel binding
0.35	GO:0046983	protein dimerization activity
0.33	GO:0003677	DNA binding
0.32	GO:0003723	RNA binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.57	GO:0032809	neuronal cell body membrane
0.57	GO:0032590	dendrite membrane
0.56	GO:0030673	axolemma
0.37	GO:0009986	cell surface
0.34	GO:0005634	nucleus
0.34	GO:0031594	neuromuscular junction
0.34	GO:0043679	axon terminus

sp|P48549|KCNJ3_HUMAN
G protein-activated inward rectifier potassium channel 1
Search

KCNJ3

0.97	G protein-activated inward rectifier potassium channel 1

0.78	GO:0034765	regulation of ion transmembrane transport
0.71	GO:0006813	potassium ion transport
0.61	GO:0098655	cation transmembrane transport
0.56	GO:0099587	inorganic ion import across plasma membrane
0.41	GO:0051602	response to electrical stimulus
0.36	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential
0.36	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential
0.35	GO:0086091	regulation of heart rate by cardiac conduction
0.33	GO:0015074	DNA integration

0.86	GO:0015467	G-protein activated inward rectifier potassium channel activity
0.36	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
0.36	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
0.35	GO:0005515	protein binding
0.32	GO:0003676	nucleic acid binding

0.52	GO:0008076	voltage-gated potassium channel complex
0.40	GO:0030315	T-tubule
0.39	GO:0009897	external side of plasma membrane

sp|P48551|INAR2_HUMAN
Interferon alpha/beta receptor 2
Search

IFNAR2

0.96	Interferon alpha and beta receptor subunit 2

0.72	GO:0060337	type I interferon signaling pathway
0.69	GO:0035455	response to interferon-alpha
0.68	GO:0035456	response to interferon-beta
0.61	GO:0051607	defense response to virus
0.41	GO:0007259	JAK-STAT cascade
0.41	GO:0008283	cell proliferation
0.39	GO:0060338	regulation of type I interferon-mediated signaling pathway
0.39	GO:0006357	regulation of transcription by RNA polymerase II
0.35	GO:0007596	blood coagulation

0.75	GO:0004905	type I interferon receptor activity
0.60	GO:0019901	protein kinase binding
0.49	GO:0019962	type I interferon binding

0.54	GO:0005887	integral component of plasma membrane
0.43	GO:0005615	extracellular space
0.33	GO:0005622	intracellular

sp|P48552|NRIP1_HUMAN
Nuclear receptor-interacting protein 1
Search

NRIP1

0.97	Nuclear receptor-interacting protein 1

0.71	GO:0006357	regulation of transcription by RNA polymerase II
0.65	GO:0001543	ovarian follicle rupture
0.63	GO:0071392	cellular response to estradiol stimulus
0.61	GO:0032922	circadian regulation of gene expression
0.58	GO:0019915	lipid storage
0.54	GO:0045893	positive regulation of transcription, DNA-templated
0.53	GO:0045892	negative regulation of transcription, DNA-templated
0.37	GO:0030521	androgen receptor signaling pathway
0.34	GO:0006351	transcription, DNA-templated
0.32	GO:0007155	cell adhesion

0.76	GO:0003712	transcription cofactor activity
0.72	GO:0005102	receptor binding
0.60	GO:0001046	core promoter sequence-specific DNA binding
0.59	GO:0042826	histone deacetylase binding
0.54	GO:0008134	transcription factor binding
0.35	GO:0046982	protein heterodimerization activity

0.61	GO:0005634	nucleus
0.54	GO:0000785	chromatin
0.51	GO:0031974	membrane-enclosed lumen
0.47	GO:1902494	catalytic complex

sp|P48553|TPC10_HUMAN
Trafficking protein particle complex subunit 10
Search

TRAPPC10

0.85	Trafficking protein particle complex subunit 10

0.85	GO:0034498	early endosome to Golgi transport
0.79	GO:0006891	intra-Golgi vesicle-mediated transport
0.60	GO:0051259	protein oligomerization
0.53	GO:0048208	COPII vesicle coating
0.50	GO:0035725	sodium ion transmembrane transport
0.45	GO:0065009	regulation of molecular function
0.30	GO:0008152	metabolic process

0.53	GO:0017112	Rab guanyl-nucleotide exchange factor activity
0.49	GO:0015081	sodium ion transmembrane transporter activity
0.41	GO:0016746	transferase activity, transferring acyl groups

0.84	GO:1990071	TRAPPII protein complex
0.67	GO:0005829	cytosol
0.49	GO:0000139	Golgi membrane
0.30	GO:0016021	integral component of membrane

0.41

EC:2.3

GO:0016746

sp|P48556|PSMD8_HUMAN
26S proteasome non-ATPase regulatory subunit 8
Search

PSMD8

0.77	26S proteasome non-ATPase regulatory subunit

0.59	GO:0006508	proteolysis
0.57	GO:1903955	positive regulation of protein targeting to mitochondrion
0.54	GO:0031647	regulation of protein stability
0.46	GO:0043248	proteasome assembly
0.44	GO:0043632	modification-dependent macromolecule catabolic process
0.43	GO:0044257	cellular protein catabolic process
0.37	GO:0009405	pathogenesis
0.37	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.37	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.36	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

0.38

GO:0090729

toxin activity

0.77	GO:0005838	proteasome regulatory particle
0.42	GO:0005829	cytosol
0.40	GO:0005634	nucleus
0.37	GO:0070062	extracellular exosome
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part

sp|P48594|SPB4_HUMAN
Serpin B4
Search

SERPINB13

0.97	Squamous cell carcinoma antigen 2

0.56	GO:0010951	negative regulation of endopeptidase activity
0.43	GO:0042270	protection from natural killer cell mediated cytotoxicity
0.39	GO:0035425	autocrine signaling
0.39	GO:1902173	negative regulation of keratinocyte apoptotic process
0.39	GO:0038001	paracrine signaling
0.39	GO:0043508	negative regulation of JUN kinase activity
0.38	GO:0010718	positive regulation of epithelial to mesenchymal transition
0.38	GO:0010950	positive regulation of endopeptidase activity
0.37	GO:0030335	positive regulation of cell migration
0.37	GO:0008284	positive regulation of cell proliferation

0.57	GO:0004867	serine-type endopeptidase inhibitor activity
0.45	GO:0002020	protease binding
0.42	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.39	GO:0104005	hijacked molecular function
0.34	GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process

0.73	GO:0005615	extracellular space
0.46	GO:0016607	nuclear speck
0.43	GO:0005829	cytosol
0.41	GO:1903561	extracellular vesicle
0.37	GO:0005775	vacuolar lumen
0.36	GO:0031410	cytoplasmic vesicle
0.36	GO:0005764	lysosome
0.36	GO:0031983	vesicle lumen
0.35	GO:0005730	nucleolus
0.34	GO:0012505	endomembrane system

sp|P48595|SPB10_HUMAN
Serpin B10
Search

SERPINB10

0.91	Serpin peptidase inhibitor, clade B (Ovalbumin), member 10

0.58	GO:0010951	negative regulation of endopeptidase activity
0.41	GO:0002244	hematopoietic progenitor cell differentiation
0.38	GO:0043312	neutrophil degranulation
0.35	GO:0043066	negative regulation of apoptotic process
0.34	GO:0042177	negative regulation of protein catabolic process

0.60	GO:0004867	serine-type endopeptidase inhibitor activity
0.33	GO:0019899	enzyme binding

0.70	GO:0005615	extracellular space
0.40	GO:0005634	nucleus
0.39	GO:0101003	ficolin-1-rich granule membrane
0.34	GO:1903561	extracellular vesicle
0.34	GO:0005886	plasma membrane
0.34	GO:0031012	extracellular matrix
0.30	GO:0031224	intrinsic component of membrane

sp|P48634|PRC2A_HUMAN
Protein PRRC2A
Search

PRRC2A

0.71	Proline rich coiled-coil 2A

0.63

GO:0030154

cell differentiation

0.68	GO:0005654	nucleoplasm
0.67	GO:0005829	cytosol
0.55	GO:0005886	plasma membrane

sp|P48637|GSHB_HUMAN
Glutathione synthetase
Search

GSS

0.53	Glutathione synthetase

0.78	GO:0006750	glutathione biosynthetic process
0.58	GO:0046686	response to cadmium ion
0.41	GO:0043200	response to amino acid
0.41	GO:0034612	response to tumor necrosis factor
0.40	GO:0006520	cellular amino acid metabolic process
0.40	GO:0007568	aging
0.39	GO:0009410	response to xenobiotic stimulus
0.39	GO:0031667	response to nutrient levels
0.34	GO:0007399	nervous system development
0.34	GO:0006979	response to oxidative stress

0.81	GO:0004363	glutathione synthase activity
0.79	GO:0043295	glutathione binding
0.69	GO:0042803	protein homodimerization activity
0.60	GO:0000287	magnesium ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0042165	neurotransmitter binding
0.39	GO:0016597	amino acid binding

0.44	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.32	GO:0009507	chloroplast

0.81	EC:6.3.2.3	GO:0004363
0.81	KEGG:R00497	GO:0004363

sp|P48643|TCPE_HUMAN
T-complex protein 1 subunit epsilon
Search

CCT5

0.79	CCT (Chaperonin containing T-complex polypeptide 1) epsilon subunit

0.69	GO:0006457	protein folding
0.58	GO:1904869	regulation of protein localization to Cajal body
0.58	GO:1904851	positive regulation of establishment of protein localization to telomere
0.57	GO:1904874	positive regulation of telomerase RNA localization to Cajal body
0.56	GO:0032212	positive regulation of telomere maintenance via telomerase
0.55	GO:0007339	binding of sperm to zona pellucida
0.54	GO:1900182	positive regulation of protein localization to nucleus
0.53	GO:0050821	protein stabilization
0.52	GO:1901998	toxin transport
0.52	GO:0009615	response to virus

0.71	GO:0051082	unfolded protein binding
0.58	GO:0031681	G-protein beta-subunit binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.55	GO:0048487	beta-tubulin binding
0.54	GO:0003730	mRNA 3'-UTR binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0048027	mRNA 5'-UTR binding
0.50	GO:0044183	protein binding involved in protein folding

0.58	GO:0005832	chaperonin-containing T-complex
0.56	GO:0002199	zona pellucida receptor complex
0.53	GO:0043209	myelin sheath
0.52	GO:0044297	cell body
0.52	GO:0005813	centrosome
0.51	GO:0005730	nucleolus
0.50	GO:0005874	microtubule
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

sp|P48645|NMU_HUMAN
Neuromedin-U
Search

NMU

0.95	Neuromedin U peptide

0.84	GO:0006940	regulation of smooth muscle contraction
0.66	GO:2000821	regulation of grooming behavior
0.64	GO:0097009	energy homeostasis
0.63	GO:0060259	regulation of feeding behavior
0.63	GO:0001659	temperature homeostasis
0.61	GO:0007218	neuropeptide signaling pathway
0.50	GO:0044495	modulation of blood pressure in other organism
0.50	GO:0120060	regulation of gastric emptying
0.49	GO:1902722	positive regulation of prolactin secretion
0.48	GO:1904058	positive regulation of sensory perception of pain

0.69	GO:0042922	neuromedin U receptor binding
0.37	GO:0005179	hormone activity

0.46	GO:0043195	terminal bouton
0.41	GO:0005576	extracellular region
0.30	GO:0016020	membrane

sp|P48651|PTSS1_HUMAN
Phosphatidylserine synthase 1
Search

PTDSS1

0.92	Phosphatidylserine synthase 1

0.84

GO:0006659

phosphatidylserine biosynthetic process

0.35

GO:0016740

transferase activity

0.47	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

0.35

GO:0016740

sp|P48664|EAA4_HUMAN
Excitatory amino acid transporter 4
Search

SLC1A6

0.45	Amino acid transporter

0.57	GO:0089711	L-glutamate transmembrane transport
0.50	GO:0042391	regulation of membrane potential
0.50	GO:0051938	L-glutamate import
0.50	GO:0089718	amino acid import across plasma membrane
0.49	GO:0001504	neurotransmitter uptake
0.48	GO:0009449	gamma-aminobutyric acid biosynthetic process
0.48	GO:0070779	D-aspartate import
0.48	GO:0089712	L-aspartate transmembrane transport
0.47	GO:0031223	auditory behavior
0.46	GO:0021545	cranial nerve development

0.72	GO:0015293	symporter activity
0.57	GO:0005313	L-glutamate transmembrane transporter activity
0.48	GO:0016595	glutamate binding
0.45	GO:0015081	sodium ion transmembrane transporter activity
0.41	GO:0022853	active ion transmembrane transporter activity
0.36	GO:0015183	L-aspartate transmembrane transporter activity
0.35	GO:0046872	metal ion binding

0.51	GO:0045111	intermediate filament cytoskeleton
0.47	GO:0005794	Golgi apparatus
0.45	GO:0043025	neuronal cell body
0.44	GO:0043005	neuron projection
0.43	GO:0009986	cell surface
0.42	GO:0005887	integral component of plasma membrane
0.34	GO:0016323	basolateral plasma membrane
0.34	GO:0098794	postsynapse
0.34	GO:0120038	plasma membrane bounded cell projection part
0.33	GO:0019866	organelle inner membrane

sp|P48668|K2C6C_HUMAN
Keratin, type II cytoskeletal 6C
Search

KRT5

0.89	Keratin, type II cytoskeletal 5

0.45	GO:0002244	hematopoietic progenitor cell differentiation
0.42	GO:0031424	keratinization
0.39	GO:0051803	negative regulation of cytolysis in other organism involved in symbiotic interaction
0.39	GO:0012501	programmed cell death
0.39	GO:0001898	regulation of cytolysis by symbiont of host cells
0.39	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
0.38	GO:0007010	cytoskeleton organization
0.38	GO:0045103	intermediate filament-based process
0.38	GO:2000536	negative regulation of entry of bacterium into host cell
0.38	GO:0050830	defense response to Gram-positive bacterium

0.62	GO:0005198	structural molecule activity
0.50	GO:0097110	scaffold protein binding

0.83	GO:0045095	keratin filament
0.41	GO:0070062	extracellular exosome
0.40	GO:0005739	mitochondrion
0.39	GO:0005886	plasma membrane
0.37	GO:0005829	cytosol
0.35	GO:0005634	nucleus
0.33	GO:0036338	viral membrane

sp|P48681|NEST_HUMAN
Nestin
Search

NES

0.97

Nestin

0.66	GO:0000086	G2/M transition of mitotic cell cycle
0.66	GO:0072089	stem cell proliferation
0.66	GO:0032091	negative regulation of protein binding
0.57	GO:0043086	negative regulation of catalytic activity
0.49	GO:0030842	regulation of intermediate filament depolymerization
0.46	GO:2000179	positive regulation of neural precursor cell proliferation
0.46	GO:0031076	embryonic camera-type eye development
0.45	GO:1901881	positive regulation of protein depolymerization
0.43	GO:0007420	brain development
0.43	GO:0051495	positive regulation of cytoskeleton organization

0.86	GO:0019215	intermediate filament binding
0.62	GO:0005198	structural molecule activity
0.38	GO:0008289	lipid binding
0.38	GO:0031730	CCR5 chemokine receptor binding

0.79	GO:0005882	intermediate filament
0.42	GO:0005737	cytoplasm
0.42	GO:0031012	extracellular matrix

sp|P48723|HSP13_HUMAN
Heat shock 70 kDa protein 13
Search

HSPA13

0.97	Testis secretory sperm-binding protein Li 199a

0.33	GO:0046854	phosphatidylinositol phosphorylation
0.32	GO:0106004	tRNA (guanine-N7)-methylation
0.32	GO:0035966	response to topologically incorrect protein

0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding
0.32	GO:0008176	tRNA (guanine-N7-)-methyltransferase activity

0.39	GO:0005783	endoplasmic reticulum
0.37	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.32

EC:2.1.1.33

GO:0008176

sp|P48728|GCST_HUMAN
Aminomethyltransferase, mitochondrial
Search

AMT

0.54	Aminomethyltransferase, mitochondrial

0.74	GO:0006546	glycine catabolic process
0.62	GO:0032259	methylation
0.33	GO:0007264	small GTPase mediated signal transduction

0.78	GO:0004047	aminomethyltransferase activity
0.66	GO:0008483	transaminase activity
0.36	GO:0031405	lipoic acid binding
0.32	GO:0003924	GTPase activity
0.32	GO:0032550	purine ribonucleoside binding
0.32	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.58	GO:0005739	mitochondrion
0.50	GO:0005654	nucleoplasm
0.33	GO:0019866	organelle inner membrane
0.30	GO:0031224	intrinsic component of membrane

0.78

EC:2.1.2.10

GO:0004047

sp|P48729|KC1A_HUMAN
Casein kinase I isoform alpha
Search

CSNK1A1

0.75	Casein kinase I alpha S

0.63	GO:0006468	protein phosphorylation
0.48	GO:0018209	peptidyl-serine modification
0.48	GO:0045104	intermediate filament cytoskeleton organization
0.47	GO:1904424	regulation of GTP binding
0.45	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.45	GO:0007030	Golgi organization
0.43	GO:0016055	Wnt signaling pathway
0.42	GO:0006909	phagocytosis
0.42	GO:0048856	anatomical structure development
0.41	GO:0048869	cellular developmental process

0.65	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005515	protein binding
0.34	GO:0042277	peptide binding
0.33	GO:0000287	magnesium ion binding

0.47	GO:0045095	keratin filament
0.47	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
0.46	GO:0030877	beta-catenin destruction complex
0.46	GO:0016607	nuclear speck
0.46	GO:0036064	ciliary basal body
0.44	GO:0005813	centrosome
0.42	GO:0000777	condensed chromosome kinetochore
0.41	GO:0005829	cytosol
0.38	GO:0030529	intracellular ribonucleoprotein complex
0.35	GO:0000139	Golgi membrane

0.65

GO:0004674

sp|P48730|KC1D_HUMAN
Casein kinase I isoform delta
Search

CSNK1D

0.73	Casein kinase I

0.63	GO:0006468	protein phosphorylation
0.52	GO:2000052	positive regulation of non-canonical Wnt signaling pathway
0.51	GO:0032922	circadian regulation of gene expression
0.51	GO:0018209	peptidyl-serine modification
0.51	GO:0071539	protein localization to centrosome
0.51	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.51	GO:0061512	protein localization to cilium
0.50	GO:1905515	non-motile cilium assembly
0.50	GO:0042752	regulation of circadian rhythm
0.50	GO:0034067	protein localization to Golgi apparatus

0.63	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0045296	cadherin binding
0.37	GO:0042277	peptide binding

0.49	GO:0005876	spindle microtubule
0.48	GO:0048471	perinuclear region of cytoplasm
0.47	GO:0005813	centrosome
0.45	GO:0005794	Golgi apparatus
0.43	GO:0005634	nucleus
0.40	GO:0005886	plasma membrane
0.37	GO:0043005	neuron projection
0.35	GO:0098588	bounding membrane of organelle
0.35	GO:0005829	cytosol
0.35	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment

sp|P48735|IDHP_HUMAN
Isocitrate dehydrogenase [NADP], mitochondrial
Search

IDH2

0.51	Isocitrate dehydrogenase [NADP], mitochondrial

0.76	GO:0006102	isocitrate metabolic process
0.64	GO:0006099	tricarboxylic acid cycle
0.40	GO:0006103	2-oxoglutarate metabolic process
0.40	GO:1904465	negative regulation of matrix metallopeptidase secretion
0.40	GO:0006097	glyoxylate cycle
0.39	GO:1903976	negative regulation of glial cell migration
0.39	GO:0060253	negative regulation of glial cell proliferation
0.37	GO:0006741	NADP biosynthetic process
0.34	GO:0007005	mitochondrion organization

0.74	GO:0004450	isocitrate dehydrogenase (NADP+) activity
0.64	GO:0051287	NAD binding
0.61	GO:0000287	magnesium ion binding

0.49	GO:0005777	peroxisome
0.46	GO:0005829	cytosol
0.44	GO:0005739	mitochondrion
0.43	GO:0019866	organelle inner membrane
0.36	GO:0070062	extracellular exosome
0.33	GO:0031974	membrane-enclosed lumen
0.30	GO:0016021	integral component of membrane

0.74

EC:1.1.1.42

GO:0004450

sp|P48736|PK3CG_HUMAN
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Search

PIK3CG

0.97	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

0.81	GO:0048015	phosphatidylinositol-mediated signaling
0.80	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
0.75	GO:0046854	phosphatidylinositol phosphorylation
0.60	GO:2000270	negative regulation of fibroblast apoptotic process
0.58	GO:0071320	cellular response to cAMP
0.58	GO:0051897	positive regulation of protein kinase B signaling
0.56	GO:1903169	regulation of calcium ion transmembrane transport
0.56	GO:0043406	positive regulation of MAP kinase activity
0.54	GO:0030593	neutrophil chemotaxis
0.51	GO:0010818	T cell chemotaxis

0.81	GO:0016303	1-phosphatidylinositol-3-kinase activity
0.58	GO:0046875	ephrin receptor binding
0.52	GO:0042802	identical protein binding
0.51	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.51	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity
0.37	GO:0004674	protein serine/threonine kinase activity
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0097367	carbohydrate derivative binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005944	phosphatidylinositol 3-kinase complex, class IB
0.45	GO:0005622	intracellular
0.44	GO:0005886	plasma membrane
0.33	GO:0043227	membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

0.81	EC:2.7.1.137	GO:0016303
0.81	KEGG:R03362	GO:0016303

sp|P48739|PIPNB_HUMAN
Phosphatidylinositol transfer protein beta isoform
Search

PITPNB

0.91	Phosphatidylinositol transfer protein beta

0.77	GO:0015914	phospholipid transport
0.42	GO:0035845	photoreceptor cell outer segment organization
0.36	GO:0001701	in utero embryonic development
0.35	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.35	GO:0006997	nucleus organization
0.33	GO:0006629	lipid metabolic process

0.78	GO:0005548	phospholipid transporter activity
0.54	GO:0031210	phosphatidylcholine binding
0.49	GO:0035091	phosphatidylinositol binding

0.44	GO:0005622	intracellular
0.40	GO:0012505	endomembrane system
0.37	GO:0043227	membrane-bounded organelle
0.36	GO:0043230	extracellular organelle
0.36	GO:0044422	organelle part
0.35	GO:0005615	extracellular space
0.30	GO:0031224	intrinsic component of membrane

sp|P48740|MASP1_HUMAN
Mannan-binding lectin serine protease 1
Search

MASP1

0.96	Mannan-binding lectin associated serine protease 3

0.64	GO:0001867	complement activation, lectin pathway
0.59	GO:0006508	proteolysis
0.42	GO:0001755	neural crest cell migration
0.42	GO:1904888	cranial skeletal system development
0.41	GO:0007507	heart development
0.39	GO:0045916	negative regulation of complement activation
0.35	GO:0006898	receptor-mediated endocytosis

0.68	GO:0005509	calcium ion binding
0.65	GO:0004252	serine-type endopeptidase activity
0.56	GO:0048306	calcium-dependent protein binding
0.51	GO:0042803	protein homodimerization activity
0.41	GO:0030246	carbohydrate binding

0.53	GO:0005576	extracellular region
0.48	GO:0005654	nucleoplasm
0.48	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.65

GO:0004252

sp|P48741|HSP77_HUMAN
Putative heat shock 70 kDa protein 7
Search

HSP70

0.46	Heat shock protein 1

0.45	GO:0090063	positive regulation of microtubule nucleation
0.44	GO:0042026	protein refolding
0.44	GO:1901673	regulation of mitotic spindle assembly
0.41	GO:0034605	cellular response to heat
0.38	GO:0043312	neutrophil degranulation
0.38	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress
0.38	GO:0010286	heat acclimation
0.37	GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
0.37	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway
0.37	GO:0090084	negative regulation of inclusion body assembly

0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.41	GO:0031072	heat shock protein binding
0.39	GO:0019899	enzyme binding
0.39	GO:0051082	unfolded protein binding
0.37	GO:0001106	RNA polymerase II transcription corepressor activity
0.37	GO:0042623	ATPase activity, coupled
0.37	GO:0055131	C3HC4-type RING finger domain binding

0.44	GO:0005815	microtubule organizing center
0.42	GO:0008180	COP9 signalosome
0.39	GO:0070062	extracellular exosome
0.39	GO:0072562	blood microparticle
0.39	GO:0005829	cytosol
0.38	GO:1904813	ficolin-1-rich granule lumen
0.36	GO:0016235	aggresome
0.36	GO:0005925	focal adhesion
0.36	GO:0016607	nuclear speck
0.35	GO:0048471	perinuclear region of cytoplasm

sp|P48742|LHX1_HUMAN
LIM/homeobox protein Lhx1
Search

LHX1

0.94	LIM homeobox protein 1

0.68	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
0.67	GO:0021527	spinal cord association neuron differentiation
0.66	GO:0021702	cerebellar Purkinje cell differentiation
0.62	GO:0030900	forebrain development
0.61	GO:2000744	positive regulation of anterior head development
0.61	GO:0097477	lateral motor column neuron migration
0.61	GO:2000768	positive regulation of nephron tubule epithelial cell differentiation
0.61	GO:0061205	paramesonephric duct development
0.61	GO:0072049	comma-shaped body morphogenesis
0.61	GO:0035847	uterine epithelium development

0.64	GO:0043565	sequence-specific DNA binding
0.54	GO:0046872	metal ion binding
0.45	GO:0003700	DNA binding transcription factor activity
0.44	GO:0003714	transcription corepressor activity
0.35	GO:0035326	enhancer binding
0.35	GO:0005515	protein binding
0.34	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.45	GO:0043234	protein complex

sp|P48745|NOV_HUMAN
Protein NOV homolog
Search

NOV

0.97	Nephroblastoma overexpressed

0.79	GO:0048659	smooth muscle cell proliferation
0.79	GO:0001558	regulation of cell growth
0.78	GO:0090027	negative regulation of monocyte chemotaxis
0.78	GO:0060392	negative regulation of SMAD protein import into nucleus
0.78	GO:1990523	bone regeneration
0.78	GO:0071603	endothelial cell-cell adhesion
0.77	GO:1902731	negative regulation of chondrocyte proliferation
0.77	GO:0044342	type B pancreatic cell proliferation
0.77	GO:0014909	smooth muscle cell migration
0.76	GO:0061484	hematopoietic stem cell homeostasis

0.83	GO:0005520	insulin-like growth factor binding
0.74	GO:0005178	integrin binding
0.73	GO:0005112	Notch binding
0.55	GO:0008201	heparin binding

0.69	GO:0005921	gap junction
0.66	GO:0005576	extracellular region
0.50	GO:0043231	intracellular membrane-bounded organelle
0.44	GO:0005737	cytoplasm
0.39	GO:0043025	neuronal cell body
0.39	GO:0030425	dendrite
0.39	GO:0030424	axon

sp|P48751|B3A3_HUMAN
Anion exchange protein 3
Search

SLC4A3

0.65	Anion exchange protein 3

0.69	GO:0015698	inorganic anion transport
0.69	GO:0098656	anion transmembrane transport
0.57	GO:0051453	regulation of intracellular pH
0.51	GO:0015701	bicarbonate transport
0.48	GO:0035725	sodium ion transmembrane transport
0.36	GO:0048565	digestive tract development
0.35	GO:0007283	spermatogenesis

0.83	GO:0005452	inorganic anion exchanger activity
0.56	GO:0015301	anion:anion antiporter activity
0.53	GO:0008510	sodium:bicarbonate symporter activity
0.36	GO:0019899	enzyme binding
0.35	GO:0015108	chloride transmembrane transporter activity
0.35	GO:0015280	ligand-gated sodium channel activity

0.44	GO:0005887	integral component of plasma membrane
0.37	GO:0016323	basolateral plasma membrane
0.36	GO:0016324	apical plasma membrane
0.34	GO:0005925	focal adhesion

sp|P48764|SL9A3_HUMAN
Sodium/hydrogen exchanger 3
Search

SLC9A3

0.58	Sodium/hydrogen exchanger

0.79	GO:0006885	regulation of pH
0.77	GO:0035725	sodium ion transmembrane transport
0.63	GO:1902600	hydrogen ion transmembrane transport
0.60	GO:0099587	inorganic ion import across plasma membrane
0.49	GO:0030004	cellular monovalent inorganic cation homeostasis
0.46	GO:0071805	potassium ion transmembrane transport
0.37	GO:0051384	response to glucocorticoid
0.35	GO:0002028	regulation of sodium ion transport
0.35	GO:0007623	circadian rhythm
0.35	GO:0010037	response to carbon dioxide

0.82	GO:0015385	sodium:proton antiporter activity
0.57	GO:0030165	PDZ domain binding
0.51	GO:0015386	potassium:proton antiporter activity

0.58	GO:0031526	brush border membrane
0.56	GO:0016324	apical plasma membrane
0.54	GO:0070062	extracellular exosome
0.36	GO:0009986	cell surface
0.30	GO:0016021	integral component of membrane

sp|P48775|T23O_HUMAN
Tryptophan 2,3-dioxygenase
Search

TDO2

0.63	Tryptophan 2,3-dioxygenase A

0.78	GO:0019441	tryptophan catabolic process to kynurenine
0.59	GO:0051289	protein homotetramerization
0.54	GO:0019442	tryptophan catabolic process to acetyl-CoA
0.53	GO:0055114	oxidation-reduction process
0.48	GO:0033060	ocellus pigmentation
0.47	GO:0006726	eye pigment biosynthetic process
0.43	GO:0044550	secondary metabolite biosynthetic process
0.37	GO:0018130	heterocycle biosynthetic process
0.37	GO:1901362	organic cyclic compound biosynthetic process
0.37	GO:0019438	aromatic compound biosynthetic process

0.83	GO:0004833	tryptophan 2,3-dioxygenase activity
0.63	GO:0020037	heme binding
0.54	GO:0046872	metal ion binding
0.52	GO:0042802	identical protein binding
0.39	GO:0019825	oxygen binding
0.38	GO:0016597	amino acid binding
0.35	GO:0008234	cysteine-type peptidase activity

0.34

GO:0005829

cytosol

0.83

EC:1.13.11.11

GO:0004833

sp|P48788|TNNI2_HUMAN
Troponin I, fast skeletal muscle
Search

TNNI2

0.92	Fast skeletal troponin I

0.54	GO:0003009	skeletal muscle contraction
0.46	GO:0060048	cardiac muscle contraction
0.45	GO:0045893	positive regulation of transcription, DNA-templated
0.38	GO:0090257	regulation of muscle system process
0.36	GO:0006887	exocytosis
0.35	GO:0030049	muscle filament sliding
0.34	GO:0055010	ventricular cardiac muscle tissue morphogenesis
0.33	GO:0048583	regulation of response to stimulus
0.32	GO:0007165	signal transduction

0.53	GO:0031014	troponin T binding
0.46	GO:0003779	actin binding
0.34	GO:0046872	metal ion binding
0.32	GO:0004871	signal transducer activity

0.84	GO:0005861	troponin complex
0.41	GO:0005634	nucleus
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|P48960|CD97_HUMAN
CD97 antigen
Search

ADGRE5

0.93	Adhesion G protein-coupled receptor E5

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.70	GO:0007166	cell surface receptor signaling pathway
0.40	GO:0071621	granulocyte chemotaxis
0.39	GO:0043304	regulation of mast cell degranulation
0.39	GO:0007155	cell adhesion
0.39	GO:0051965	positive regulation of synapse assembly
0.34	GO:0006954	inflammatory response
0.33	GO:0006468	protein phosphorylation
0.30	GO:0002366	leukocyte activation involved in immune response
0.30	GO:0002443	leukocyte mediated immunity

0.72	GO:0004930	G-protein coupled receptor activity
0.68	GO:0005509	calcium ion binding
0.41	GO:0035374	chondroitin sulfate binding
0.36	GO:0017049	GTP-Rho binding
0.34	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0005201	extracellular matrix structural constituent
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.39	GO:0031256	leading edge membrane
0.37	GO:0005925	focal adhesion
0.37	GO:0070062	extracellular exosome
0.34	GO:0001726	ruffle
0.34	GO:0031253	cell projection membrane
0.33	GO:0005578	proteinaceous extracellular matrix
0.30	GO:0030141	secretory granule
0.30	GO:0016021	integral component of membrane
0.30	GO:0044446	intracellular organelle part
0.30	GO:0098805	whole membrane

0.34

GO:0004674

sp|P48995|TRPC1_HUMAN
Short transient receptor potential channel 1
Search

TRPC1

0.97	Short transient receptor potential channel 1

0.76	GO:0070588	calcium ion transmembrane transport
0.58	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
0.58	GO:0042438	melanin biosynthetic process
0.57	GO:0051592	response to calcium ion
0.48	GO:0046847	filopodium assembly
0.48	GO:0006828	manganese ion transport
0.47	GO:0001570	vasculogenesis
0.46	GO:0001525	angiogenesis
0.37	GO:0046541	saliva secretion
0.36	GO:0044057	regulation of system process

0.78	GO:0005262	calcium channel activity
0.57	GO:0070679	inositol 1,4,5 trisphosphate binding
0.38	GO:0044325	ion channel binding

0.54	GO:0043235	receptor complex
0.44	GO:0005886	plasma membrane
0.37	GO:0043034	costamere
0.36	GO:0030017	sarcomere
0.36	GO:0045121	membrane raft
0.34	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

sp|P49005|DPOD2_HUMAN
DNA polymerase delta subunit 2
Search

POLD2

0.91	LOW QUALITY PROTEIN: DNA polymerase delta subunit 2

0.64	GO:0071897	DNA biosynthetic process
0.63	GO:0006260	DNA replication
0.47	GO:0022616	DNA strand elongation
0.42	GO:0006974	cellular response to DNA damage stimulus
0.35	GO:0000723	telomere maintenance
0.35	GO:0006266	DNA ligation
0.34	GO:0051606	detection of stimulus
0.34	GO:0022402	cell cycle process
0.34	GO:0019725	cellular homeostasis
0.34	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.67	GO:0003887	DNA-directed DNA polymerase activity
0.52	GO:0003677	DNA binding
0.33	GO:0005515	protein binding

0.51	GO:0043625	delta DNA polymerase complex
0.50	GO:0005654	nucleoplasm
0.33	GO:0030532	small nuclear ribonucleoprotein complex
0.30	GO:0031224	intrinsic component of membrane

0.67

GO:0003887

sp|P49006|MRP_HUMAN
MARCKS-related protein
Search

MARCKSL1

0.96	Myristoylated alanine rich protein kinase C substrate

0.52	GO:0008284	positive regulation of cell proliferation
0.41	GO:0051764	actin crosslink formation
0.40	GO:0051017	actin filament bundle assembly
0.39	GO:0010842	retina layer formation
0.39	GO:0035914	skeletal muscle cell differentiation
0.39	GO:0051260	protein homooligomerization
0.38	GO:0060541	respiratory system development
0.38	GO:0007420	brain development
0.37	GO:0016310	phosphorylation
0.36	GO:0003381	epithelial cell morphogenesis involved in gastrulation

0.79	GO:0005516	calmodulin binding
0.43	GO:0003779	actin binding
0.40	GO:0005080	protein kinase C binding
0.38	GO:0032403	protein complex binding
0.38	GO:0042802	identical protein binding
0.37	GO:0016301	kinase activity
0.33	GO:0001786	phosphatidylserine binding

0.43	GO:0071944	cell periphery
0.41	GO:0042585	germinal vesicle
0.40	GO:0032432	actin filament bundle
0.39	GO:0070062	extracellular exosome
0.39	GO:0005813	centrosome
0.38	GO:0099568	cytoplasmic region
0.34	GO:0005925	focal adhesion
0.33	GO:0044307	dendritic branch
0.33	GO:0032059	bleb
0.33	GO:0001520	outer dense fiber

sp|P49019|HCAR3_HUMAN
Hydroxycarboxylic acid receptor 3
Search

HCAR1

0.94	Hydroxycarboxylic acid receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.49	GO:0070165	positive regulation of adiponectin secretion
0.48	GO:0001781	neutrophil apoptotic process
0.47	GO:0033031	positive regulation of neutrophil apoptotic process
0.47	GO:0035590	purinergic nucleotide receptor signaling pathway
0.46	GO:0050995	negative regulation of lipid catabolic process

0.72	GO:0004930	G-protein coupled receptor activity
0.47	GO:0016502	nucleotide receptor activity
0.46	GO:0035586	purinergic receptor activity
0.41	GO:0032550	purine ribonucleoside binding
0.41	GO:0019001	guanyl nucleotide binding
0.37	GO:0032555	purine ribonucleotide binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding

0.43	GO:0030054	cell junction
0.39	GO:0005886	plasma membrane
0.33	GO:0043229	intracellular organelle
0.30	GO:0016021	integral component of membrane

sp|P49023|PAXI_HUMAN
Paxillin
Search

PXN

0.90	Paxillin a

0.81	GO:0007160	cell-matrix adhesion
0.57	GO:0060396	growth hormone receptor signaling pathway
0.57	GO:0051496	positive regulation of stress fiber assembly
0.56	GO:0043542	endothelial cell migration
0.55	GO:0007179	transforming growth factor beta receptor signaling pathway
0.51	GO:0034614	cellular response to reactive oxygen species
0.41	GO:0061055	myotome development
0.38	GO:0009653	anatomical structure morphogenesis
0.38	GO:0007045	cell-substrate adherens junction assembly
0.38	GO:0030032	lamellipodium assembly

0.69	GO:0017166	vinculin binding
0.58	GO:0038191	neuropilin binding
0.55	GO:0008013	beta-catenin binding
0.53	GO:0046872	metal ion binding
0.39	GO:0051435	BH4 domain binding
0.39	GO:0005178	integrin binding
0.38	GO:0031625	ubiquitin protein ligase binding
0.38	GO:0019901	protein kinase binding
0.36	GO:0030159	receptor signaling complex scaffold activity
0.34	GO:0004867	serine-type endopeptidase inhibitor activity

0.68	GO:0005856	cytoskeleton
0.64	GO:0005925	focal adhesion
0.54	GO:0030027	lamellipodium
0.49	GO:0005829	cytosol
0.48	GO:0044446	intracellular organelle part
0.46	GO:0005886	plasma membrane
0.39	GO:0005938	cell cortex
0.35	GO:0098857	membrane microdomain
0.33	GO:0043234	protein complex

sp|P49069|CAMLG_HUMAN
Calcium signal-modulating cyclophilin ligand
Search

CAMLG

0.97	Calcium signal-modulating cyclophilin ligand

0.56	GO:0001881	receptor recycling
0.55	GO:0007173	epidermal growth factor receptor signaling pathway
0.35	GO:0006952	defense response
0.34	GO:0016032	viral process

0.39

GO:0050839

cell adhesion molecule binding

0.54	GO:0005783	endoplasmic reticulum
0.30	GO:0044425	membrane part

sp|P49116|NR2C2_HUMAN
Nuclear receptor subfamily 2 group C member 2
Search

NR2C2

0.87	Nuclear receptor subfamily 2 group C member 2

0.79	GO:0043401	steroid hormone mediated signaling pathway
0.66	GO:0030522	intracellular receptor signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.40	GO:0048386	positive regulation of retinoic acid receptor signaling pathway
0.38	GO:0051254	positive regulation of RNA metabolic process
0.38	GO:0010557	positive regulation of macromolecule biosynthetic process
0.38	GO:0031328	positive regulation of cellular biosynthetic process

0.80	GO:0003707	steroid hormone receptor activity
0.67	GO:0004879	nuclear receptor activity
0.63	GO:0043565	sequence-specific DNA binding
0.62	GO:0008270	zinc ion binding
0.42	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.42	GO:0001012	RNA polymerase II regulatory region DNA binding
0.40	GO:0003690	double-stranded DNA binding
0.40	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.39	GO:0046983	protein dimerization activity
0.38	GO:0042826	histone deacetylase binding

0.61	GO:0005634	nucleus
0.40	GO:0043233	organelle lumen
0.38	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|P49137|MAPK2_HUMAN
MAP kinase-activated protein kinase 2
Search

MAPKAPK2

0.86	Mitogen-activated protein kinase-activated protein kinase 2

0.63	GO:0044351	macropinocytosis
0.63	GO:0006468	protein phosphorylation
0.60	GO:0070935	3'-UTR-mediated mRNA stabilization
0.59	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
0.59	GO:0018209	peptidyl-serine modification
0.58	GO:0002224	toll-like receptor signaling pathway
0.58	GO:0032496	response to lipopolysaccharide
0.58	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.58	GO:0035924	cellular response to vascular endothelial growth factor stimulus
0.57	GO:0032675	regulation of interleukin-6 production

0.64	GO:0004674	protein serine/threonine kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0051019	mitogen-activated protein kinase binding
0.52	GO:0010857	calcium-dependent protein kinase activity
0.48	GO:0005516	calmodulin binding
0.43	GO:0004871	signal transducer activity

0.53	GO:0005813	centrosome
0.52	GO:0005654	nucleoplasm
0.40	GO:0005737	cytoplasm
0.37	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.64

GO:0004674

sp|P49146|NPY2R_HUMAN
Neuropeptide Y receptor type 2
Search

NPY2R

0.96	Neuropeptide Y receptor type 2

0.79	GO:0007218	neuropeptide signaling pathway
0.59	GO:0003214	cardiac left ventricle morphogenesis
0.57	GO:0003151	outflow tract morphogenesis
0.53	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.46	GO:0007631	feeding behavior
0.44	GO:0007268	chemical synaptic transmission
0.40	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep
0.40	GO:0033603	positive regulation of dopamine secretion
0.40	GO:2000252	negative regulation of feeding behavior
0.40	GO:0051967	negative regulation of synaptic transmission, glutamatergic

0.84	GO:0004983	neuropeptide Y receptor activity
0.46	GO:0042923	neuropeptide binding
0.35	GO:0005246	calcium channel regulator activity
0.33	GO:0005515	protein binding

0.52	GO:0097730	non-motile cilium
0.37	GO:0005886	plasma membrane
0.33	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

sp|P49184|DNSL1_HUMAN
Deoxyribonuclease-1-like 1
Search

DNASE1L1

0.62	Deoxyribonuclease gamma

0.76	GO:0006308	DNA catabolic process
0.56	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.39	GO:0006955	immune response
0.37	GO:0016192	vesicle-mediated transport
0.37	GO:0042119	neutrophil activation
0.36	GO:0098657	import into cell
0.36	GO:0002446	neutrophil mediated immunity
0.35	GO:0030262	apoptotic nuclear changes
0.34	GO:0070948	regulation of neutrophil mediated cytotoxicity
0.34	GO:0032940	secretion by cell

0.71	GO:0004536	deoxyribonuclease activity
0.58	GO:0004519	endonuclease activity
0.38	GO:0005044	scavenger receptor activity
0.37	GO:0030247	polysaccharide binding
0.33	GO:0003677	DNA binding

0.50	GO:0005783	endoplasmic reticulum
0.40	GO:0005634	nucleus
0.37	GO:0070062	extracellular exosome
0.37	GO:0035580	specific granule lumen
0.30	GO:0031224	intrinsic component of membrane

sp|P49189|AL9A1_HUMAN
4-trimethylaminobutyraldehyde dehydrogenase
Search

ALDH9A1

0.61	Gamma-aminobutyraldehyde dehydrogenase

0.53	GO:0055114	oxidation-reduction process
0.52	GO:0042136	neurotransmitter biosynthetic process
0.49	GO:0006081	cellular aldehyde metabolic process
0.40	GO:0045329	carnitine biosynthetic process
0.35	GO:0001889	liver development
0.34	GO:0001822	kidney development
0.34	GO:0042445	hormone metabolic process
0.34	GO:0019285	glycine betaine biosynthetic process from choline

0.69	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.35	GO:0033737	1-pyrroline dehydrogenase activity
0.35	GO:0043176	amine binding
0.34	GO:0042803	protein homodimerization activity
0.33	GO:0051287	NAD binding

0.36	GO:0070062	extracellular exosome
0.36	GO:0005829	cytosol
0.34	GO:0005739	mitochondrion

0.69

GO:0016620

sp|P49190|PTH2R_HUMAN
Parathyroid hormone 2 receptor
Search

0.91	Parathyroid hormone receptor

0.71	GO:0007166	cell surface receptor signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.49	GO:0002076	osteoblast development
0.49	GO:0045453	bone resorption
0.49	GO:0030282	bone mineralization
0.48	GO:0019933	cAMP-mediated signaling
0.48	GO:0002062	chondrocyte differentiation
0.47	GO:0048469	cell maturation
0.46	GO:0006874	cellular calcium ion homeostasis
0.46	GO:0008285	negative regulation of cell proliferation

0.77	GO:0004991	parathyroid hormone receptor activity
0.51	GO:0017046	peptide hormone binding
0.49	GO:0043621	protein self-association
0.45	GO:0042803	protein homodimerization activity
0.40	GO:0001653	peptide receptor activity

0.51	GO:0005886	plasma membrane
0.37	GO:0005903	brush border
0.37	GO:0045177	apical part of cell
0.37	GO:0043235	receptor complex
0.36	GO:0120038	plasma membrane bounded cell projection part
0.35	GO:0005622	intracellular
0.34	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

sp|P49207|RL34_HUMAN
60S ribosomal protein L34
Search

RPL34

0.74	Ribosomal protein L34

0.58	GO:0043043	peptide biosynthetic process
0.54	GO:0044267	cellular protein metabolic process
0.52	GO:0010467	gene expression
0.51	GO:0009059	macromolecule biosynthetic process
0.40	GO:0042254	ribosome biogenesis
0.35	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.34	GO:0019083	viral transcription
0.34	GO:0016072	rRNA metabolic process

0.62	GO:0003735	structural constituent of ribosome
0.46	GO:0045296	cadherin binding
0.38	GO:0003723	RNA binding

0.59	GO:0005840	ribosome
0.42	GO:0044445	cytosolic part
0.40	GO:0005739	mitochondrion
0.38	GO:0044446	intracellular organelle part
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

sp|P49221|TGM4_HUMAN
Protein-glutamine gamma-glutamyltransferase 4
Search

TGM4

0.90	Prostate-specific transglutaminase 4

0.84	GO:0018149	peptide cross-linking
0.47	GO:0030216	keratinocyte differentiation
0.45	GO:0051262	protein tetramerization
0.43	GO:0043163	cell envelope organization
0.38	GO:0042628	mating plug formation
0.37	GO:0072378	blood coagulation, fibrin clot formation
0.34	GO:0031069	hair follicle morphogenesis
0.34	GO:0007018	microtubule-based movement
0.34	GO:0035315	hair cell differentiation

0.84	GO:0003810	protein-glutamine gamma-glutamyltransferase activity
0.42	GO:0005509	calcium ion binding
0.34	GO:0003777	microtubule motor activity
0.34	GO:0008017	microtubule binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.46	GO:0031012	extracellular matrix
0.45	GO:0005794	Golgi apparatus
0.45	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.38	GO:0070062	extracellular exosome
0.34	GO:0031225	anchored component of membrane
0.34	GO:0001533	cornified envelope

0.84

EC:2.3.2.13

GO:0003810

sp|P49223|SPIT3_HUMAN
Kunitz-type protease inhibitor 3
Search

SPINT3

0.74	Kunitz-type protease inhibitor 3

0.76	GO:0010951	negative regulation of endopeptidase activity
0.46	GO:0007596	blood coagulation
0.43	GO:0006508	proteolysis
0.39	GO:0006030	chitin metabolic process
0.39	GO:0044559	envenomation resulting in modulation of voltage-gated potassium channel activity in other organism
0.38	GO:0045214	sarcomere organization
0.38	GO:0007399	nervous system development
0.38	GO:1903706	regulation of hemopoiesis
0.38	GO:0007507	heart development
0.36	GO:0009405	pathogenesis

0.79	GO:0004867	serine-type endopeptidase inhibitor activity
0.43	GO:0008233	peptidase activity
0.38	GO:0008061	chitin binding
0.36	GO:0090729	toxin activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0016491	oxidoreductase activity
0.33	GO:0005198	structural molecule activity
0.32	GO:0016301	kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.48	GO:0005576	extracellular region
0.35	GO:0033644	host cell membrane
0.34	GO:0030117	membrane coat
0.33	GO:0005634	nucleus
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.43

GO:0008233

sp|P49238|CX3C1_HUMAN
CX3C chemokine receptor 1
Search

CX3CR1

0.97	C-X3-C motif chemokine receptor 1

0.84	GO:0070098	chemokine-mediated signaling pathway
0.71	GO:0006935	chemotaxis
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.63	GO:0007155	cell adhesion
0.51	GO:0006955	immune response
0.48	GO:0001774	microglial cell activation
0.48	GO:1905517	macrophage migration
0.47	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
0.47	GO:0021795	cerebral cortex cell migration
0.46	GO:0016525	negative regulation of angiogenesis

0.85	GO:0004950	chemokine receptor activity
0.61	GO:0019960	C-X3-C chemokine binding
0.39	GO:0019957	C-C chemokine binding
0.36	GO:0005044	scavenger receptor activity
0.36	GO:0031727	CCR2 chemokine receptor binding
0.35	GO:0004435	phosphatidylinositol phospholipase C activity
0.33	GO:0003779	actin binding

0.49	GO:0005654	nucleoplasm
0.40	GO:0032809	neuronal cell body membrane
0.39	GO:0048471	perinuclear region of cytoplasm
0.38	GO:0043005	neuron projection
0.37	GO:0009897	external side of plasma membrane
0.34	GO:0005887	integral component of plasma membrane
0.33	GO:0005768	endosome

0.35	EC:3.1.4.11	GO:0004435
0.35	KEGG:R03435	GO:0004435

sp|P49247|RPIA_HUMAN
Ribose-5-phosphate isomerase
Search

RPIA

0.46	Ribose 5-phosphate isomerase A

0.80	GO:0009052	pentose-phosphate shunt, non-oxidative branch
0.47	GO:0006014	D-ribose metabolic process

0.79	GO:0004751	ribose-5-phosphate isomerase activity
0.50	GO:0042802	identical protein binding
0.37	GO:0048029	monosaccharide binding

0.44	GO:0005829	cytosol
0.39	GO:0043231	intracellular membrane-bounded organelle

0.79	EC:5.3.1.6	GO:0004751
0.79	KEGG:R01056	GO:0004751

sp|P49257|LMAN1_HUMAN
Protein ERGIC-53
Search

LMAN1

0.96	Lectin, mannose binding 1

0.78	GO:0006888	ER to Golgi vesicle-mediated transport
0.55	GO:0007029	endoplasmic reticulum organization
0.55	GO:0007030	Golgi organization
0.52	GO:0010638	positive regulation of organelle organization
0.45	GO:0071391	cellular response to estrogen stimulus
0.37	GO:0034498	early endosome to Golgi transport
0.37	GO:0032527	protein exit from endoplasmic reticulum
0.35	GO:0006901	vesicle coating
0.35	GO:0018279	protein N-linked glycosylation via asparagine
0.35	GO:0048199	vesicle targeting, to, from or within Golgi

0.85	GO:0005537	mannose binding
0.35	GO:0005515	protein binding
0.34	GO:0046872	metal ion binding
0.33	GO:0043023	ribosomal large subunit binding
0.33	GO:0043022	ribosome binding
0.33	GO:0003743	translation initiation factor activity
0.32	GO:0003677	DNA binding

0.56	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.54	GO:0044220	host cell perinuclear region of cytoplasm
0.54	GO:0030017	sarcomere
0.53	GO:0030134	COPII-coated ER to Golgi transport vesicle
0.50	GO:0005794	Golgi apparatus
0.37	GO:0005789	endoplasmic reticulum membrane
0.37	GO:0098588	bounding membrane of organelle
0.36	GO:0070062	extracellular exosome
0.34	GO:0030133	transport vesicle
0.34	GO:0030659	cytoplasmic vesicle membrane

sp|P49279|NRAM1_HUMAN
Natural resistance-associated macrophage protein 1
Search

SLC11A1

0.96	Natural resistance-associated macrophages protein 1

0.66	GO:0030001	metal ion transport
0.59	GO:0045342	MHC class II biosynthetic process
0.59	GO:0032632	interleukin-3 production
0.58	GO:0002309	T cell proliferation involved in immune response
0.58	GO:0006876	cellular cadmium ion homeostasis
0.57	GO:0002606	positive regulation of dendritic cell antigen processing and presentation
0.57	GO:0032623	interleukin-2 production
0.57	GO:0060586	multicellular organismal iron ion homeostasis
0.57	GO:0002369	T cell cytokine production
0.57	GO:0043091	L-arginine import

0.69	GO:0046873	metal ion transmembrane transporter activity
0.50	GO:0015491	cation:cation antiporter activity
0.49	GO:0042803	protein homodimerization activity
0.49	GO:0015299	solute:proton antiporter activity
0.34	GO:0072509	divalent inorganic cation transmembrane transporter activity
0.33	GO:0016791	phosphatase activity

0.56	GO:0070821	tertiary granule membrane
0.56	GO:0030670	phagocytic vesicle membrane
0.52	GO:0005770	late endosome
0.51	GO:0005764	lysosome
0.51	GO:0010008	endosome membrane
0.41	GO:0005886	plasma membrane
0.36	GO:0101003	ficolin-1-rich granule membrane
0.35	GO:0009986	cell surface
0.34	GO:0005635	nuclear envelope
0.30	GO:0016021	integral component of membrane

0.33

EC:3.1.3 EC:3.1.3.41

GO:0016791

sp|P49281|NRAM2_HUMAN
Natural resistance-associated macrophage protein 2
Search

SLC11A2

0.87	Natural resistance-associated macrophage protein 2

0.66	GO:0030001	metal ion transport
0.48	GO:0060586	multicellular organismal iron ion homeostasis
0.47	GO:0048821	erythrocyte development
0.47	GO:0010039	response to iron ion
0.46	GO:0048813	dendrite morphogenesis
0.46	GO:0007611	learning or memory
0.43	GO:0072511	divalent inorganic cation transport
0.43	GO:0006783	heme biosynthetic process
0.42	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
0.40	GO:0003032	detection of oxygen

0.69	GO:0046873	metal ion transmembrane transporter activity
0.50	GO:0015094	lead ion transmembrane transporter activity
0.49	GO:0046870	cadmium ion binding
0.45	GO:0072509	divalent inorganic cation transmembrane transporter activity
0.44	GO:0015295	solute:proton symporter activity
0.42	GO:0070835	chromium ion transmembrane transporter activity
0.36	GO:0050897	cobalt ion binding
0.36	GO:0016151	nickel cation binding
0.35	GO:0030145	manganese ion binding
0.35	GO:0005507	copper ion binding

0.50	GO:0070826	paraferritin complex
0.47	GO:0031526	brush border membrane
0.47	GO:0045178	basal part of cell
0.46	GO:0031902	late endosome membrane
0.46	GO:0055037	recycling endosome
0.46	GO:0005765	lysosomal membrane
0.45	GO:0016324	apical plasma membrane
0.45	GO:1903561	extracellular vesicle
0.45	GO:0005769	early endosome
0.45	GO:0048471	perinuclear region of cytoplasm

sp|P49286|MTR1B_HUMAN
Melatonin receptor type 1B
Search

MTNR1B

0.89	Melatonin receptor subtype two

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.48	GO:0050796	regulation of insulin secretion
0.48	GO:0030823	regulation of cGMP metabolic process
0.47	GO:0042593	glucose homeostasis
0.47	GO:0007623	circadian rhythm
0.47	GO:0030804	positive regulation of cyclic nucleotide biosynthetic process
0.47	GO:1900373	positive regulation of purine nucleotide biosynthetic process
0.36	GO:1900543	negative regulation of purine nucleotide metabolic process
0.36	GO:0007268	chemical synaptic transmission
0.36	GO:0051198	negative regulation of coenzyme metabolic process

0.85	GO:0008502	melatonin receptor activity
0.47	GO:0042562	hormone binding
0.35	GO:0097159	organic cyclic compound binding
0.35	GO:0005515	protein binding
0.34	GO:0033218	amide binding
0.32	GO:0008144	drug binding
0.32	GO:1901363	heterocyclic compound binding

0.45	GO:0043235	receptor complex
0.43	GO:0005887	integral component of plasma membrane

sp|P49321|NASP_HUMAN
Nuclear autoantigenic sperm protein
Search

NASP

0.87	Nuclear autoantigenic sperm protein (Histone-binding)

0.84	GO:0006335	DNA replication-dependent nucleosome assembly
0.80	GO:0006336	DNA replication-independent nucleosome assembly
0.55	GO:0001824	blastocyst development
0.54	GO:0043486	histone exchange
0.53	GO:0000082	G1/S transition of mitotic cell cycle
0.52	GO:0008283	cell proliferation
0.51	GO:0033574	response to testosterone
0.49	GO:0008584	male gonad development
0.46	GO:0006260	DNA replication
0.44	GO:0015031	protein transport

0.76	GO:0042393	histone binding
0.46	GO:0032403	protein complex binding
0.41	GO:0051879	Hsp90 protein binding
0.39	GO:0016491	oxidoreductase activity

0.71	GO:0000790	nuclear chromatin
0.67	GO:0005654	nucleoplasm
0.57	GO:0043234	protein complex
0.38	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.39

GO:0016491

sp|P49326|FMO5_HUMAN
Dimethylaniline monooxygenase [N-oxide-forming] 5
Search

FMO5

0.60	Flavin-containing monooxygenase

0.52

GO:0055114

oxidation-reduction process

0.78	GO:0004499	N,N-dimethylaniline monooxygenase activity
0.69	GO:0050661	NADP binding
0.66	GO:0050660	flavin adenine dinucleotide binding

0.48	GO:0005783	endoplasmic reticulum
0.46	GO:0005829	cytosol
0.38	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.37	GO:0031984	organelle subcompartment
0.36	GO:0031090	organelle membrane
0.30	GO:0031224	intrinsic component of membrane

0.78

EC:1.14.13.8

GO:0004499

sp|P49327|FAS_HUMAN
Fatty acid synthase
Search

FASN

0.73	Fatty acid synthase

0.57	GO:0071353	cellular response to interleukin-4
0.53	GO:0030879	mammary gland development
0.52	GO:0055114	oxidation-reduction process
0.49	GO:0006633	fatty acid biosynthetic process
0.38	GO:0001649	osteoblast differentiation
0.38	GO:0032100	positive regulation of appetite
0.38	GO:0006084	acetyl-CoA metabolic process
0.36	GO:0045540	regulation of cholesterol biosynthetic process
0.36	GO:0046949	fatty-acyl-CoA biosynthetic process
0.36	GO:0006089	lactate metabolic process

0.84	GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
0.84	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity
0.83	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity
0.83	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity
0.83	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity
0.82	GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
0.76	GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity
0.74	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
0.74	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity
0.72	GO:0031177	phosphopantetheine binding

0.59	GO:0042587	glycogen granule
0.49	GO:0005794	Golgi apparatus
0.48	GO:0005829	cytosol
0.44	GO:0005739	mitochondrion
0.42	GO:0005886	plasma membrane
0.41	GO:0042470	melanosome
0.37	GO:0070062	extracellular exosome

0.84	EC:4.2.1.61	GO:0004317
0.84	KEGG:R04462	GO:0004317

sp|P49335|PO3F4_HUMAN
POU domain, class 3, transcription factor 4
Search

POU3F4

0.73	POU domain, class 3, transcription factor 4-A

0.77	GO:0007420	brain development
0.68	GO:0006357	regulation of transcription by RNA polymerase II
0.58	GO:0006351	transcription, DNA-templated
0.58	GO:2001054	negative regulation of mesenchymal cell apoptotic process
0.57	GO:0090103	cochlea morphogenesis
0.54	GO:0021953	central nervous system neuron differentiation
0.53	GO:0007605	sensory perception of sound
0.41	GO:0061351	neural precursor cell proliferation
0.39	GO:0016477	cell migration
0.39	GO:0009888	tissue development

0.64	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.52	GO:0001012	RNA polymerase II regulatory region DNA binding
0.50	GO:0003690	double-stranded DNA binding
0.38	GO:0001105	RNA polymerase II transcription coactivator activity
0.38	GO:0071837	HMG box domain binding
0.36	GO:0042802	identical protein binding

0.61	GO:0005634	nucleus
0.37	GO:0005667	transcription factor complex
0.30	GO:0031224	intrinsic component of membrane

sp|P49336|CDK8_HUMAN
Cyclin-dependent kinase 8
Search

CDK8

0.96	Cell division protein kinase 8

0.60	GO:0006468	protein phosphorylation
0.44	GO:0007346	regulation of mitotic cell cycle
0.37	GO:0051301	cell division
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0010468	regulation of gene expression
0.34	GO:1902680	positive regulation of RNA biosynthetic process

0.60	GO:0004672	protein kinase activity
0.52	GO:0032559	adenyl ribonucleotide binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0060089	molecular transducer activity
0.34	GO:0005515	protein binding

0.53	GO:0016592	mediator complex
0.49	GO:0005730	nucleolus

sp|P49354|FNTA_HUMAN
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Search

FNTA

0.89	Hook microtubule-tethering protein 3

0.82	GO:0097354	prenylation
0.60	GO:0036211	protein modification process
0.59	GO:0090044	positive regulation of tubulin deacetylation
0.58	GO:0090045	positive regulation of deacetylase activity
0.56	GO:0044267	cellular protein metabolic process
0.55	GO:0045213	neurotransmitter receptor metabolic process
0.54	GO:0071340	skeletal muscle acetylcholine-gated channel clustering
0.53	GO:0099601	regulation of neurotransmitter receptor activity
0.38	GO:0022027	interkinetic nuclear migration
0.37	GO:0051645	Golgi localization

0.83	GO:0008318	protein prenyltransferase activity
0.56	GO:0043014	alpha-tubulin binding
0.53	GO:0030548	acetylcholine receptor regulator activity
0.52	GO:0030971	receptor tyrosine kinase binding
0.50	GO:0008017	microtubule binding
0.36	GO:0042802	identical protein binding
0.35	GO:0019840	isoprenoid binding
0.35	GO:0042277	peptide binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0008144	drug binding

0.60	GO:0005953	CAAX-protein geranylgeranyltransferase complex
0.57	GO:0005965	protein farnesyltransferase complex
0.51	GO:0005875	microtubule associated complex
0.40	GO:0005886	plasma membrane
0.38	GO:0070695	FHF complex
0.37	GO:0000242	pericentriolar material
0.37	GO:0034451	centriolar satellite
0.37	GO:0030897	HOPS complex
0.37	GO:0005801	cis-Golgi network
0.36	GO:0005829	cytosol

0.83

EC:2.5.1

GO:0008318

sp|P49356|FNTB_HUMAN
Protein farnesyltransferase subunit beta
Search

0.87	CHURC1-FNTB readthrough

0.85	GO:0018343	protein farnesylation
0.76	GO:0042127	regulation of cell proliferation
0.60	GO:0042060	wound healing
0.57	GO:0048522	positive regulation of cellular process
0.55	GO:0010557	positive regulation of macromolecule biosynthetic process
0.55	GO:0010628	positive regulation of gene expression
0.54	GO:0051173	positive regulation of nitrogen compound metabolic process
0.54	GO:0007275	multicellular organism development
0.52	GO:0048523	negative regulation of cellular process
0.46	GO:1903506	regulation of nucleic acid-templated transcription

0.61	GO:0004659	prenyltransferase activity
0.50	GO:0008270	zinc ion binding
0.43	GO:0140096	catalytic activity, acting on a protein

0.85

GO:0005965

protein farnesyltransferase complex

0.61

EC:2.5.1

GO:0004659

sp|P49366|DHYS_HUMAN
Deoxyhypusine synthase
Search

DHPS

0.63	Deoxyhypusine synthase

0.82	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine
0.55	GO:0042102	positive regulation of T cell proliferation
0.53	GO:0042593	glucose homeostasis
0.52	GO:0008216	spermidine metabolic process
0.45	GO:0031017	exocrine pancreas development
0.45	GO:0003323	type B pancreatic cell development
0.40	GO:0006598	polyamine catabolic process
0.40	GO:0051289	protein homotetramerization
0.37	GO:0006888	ER to Golgi vesicle-mediated transport
0.36	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly

0.61	GO:0034038	deoxyhypusine synthase activity
0.50	GO:0042802	identical protein binding
0.33	GO:0050660	flavin adenine dinucleotide binding
0.32	GO:0016787	hydrolase activity

0.37	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.61

EC:2.5.1.46

GO:0034038

sp|P49368|TCPG_HUMAN
T-complex protein 1 subunit gamma
Search

CCT3

0.69	T-complex protein 1 subunit gamma

0.68	GO:0006457	protein folding
0.58	GO:1904869	regulation of protein localization to Cajal body
0.58	GO:1904874	positive regulation of telomerase RNA localization to Cajal body
0.56	GO:0032212	positive regulation of telomere maintenance via telomerase
0.55	GO:1900182	positive regulation of protein localization to nucleus
0.55	GO:0046931	pore complex assembly
0.54	GO:0007339	binding of sperm to zona pellucida
0.53	GO:0050821	protein stabilization
0.52	GO:1901998	toxin transport
0.47	GO:0046671	negative regulation of retinal cell programmed cell death

0.70	GO:0051082	unfolded protein binding
0.58	GO:0044183	protein binding involved in protein folding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.34	GO:0003723	RNA binding
0.33	GO:0046983	protein dimerization activity

0.58	GO:0005832	chaperonin-containing T-complex
0.56	GO:0002199	zona pellucida receptor complex
0.52	GO:0043209	myelin sheath
0.52	GO:0044297	cell body
0.50	GO:0005874	microtubule
0.42	GO:0005886	plasma membrane
0.36	GO:0070062	extracellular exosome
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

sp|P49406|RM19_HUMAN
39S ribosomal protein L19, mitochondrial
Search

MRPL19

0.95	Mitochondrial ribosomal protein L19

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.34	GO:0043624	cellular protein complex disassembly

0.64

GO:0003735

structural constituent of ribosome

0.61	GO:0005840	ribosome
0.54	GO:0031965	nuclear membrane
0.54	GO:0005759	mitochondrial matrix
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0019866	organelle inner membrane

sp|P49407|ARRB1_HUMAN
Beta-arrestin-1
Search

ARRB1

0.95	Beta-arrestin-1

0.61	GO:0007165	signal transduction
0.57	GO:0045746	negative regulation of Notch signaling pathway
0.54	GO:0043393	regulation of protein binding
0.54	GO:0090240	positive regulation of histone H4 acetylation
0.54	GO:0002031	G-protein coupled receptor internalization
0.54	GO:0002092	positive regulation of receptor internalization
0.54	GO:0032717	negative regulation of interleukin-8 production
0.54	GO:0043149	stress fiber assembly
0.53	GO:0032715	negative regulation of interleukin-6 production
0.53	GO:0035025	positive regulation of Rho protein signal transduction

0.55	GO:1990763	arrestin family protein binding
0.54	GO:0031701	angiotensin receptor binding
0.54	GO:0031434	mitogen-activated protein kinase kinase binding
0.53	GO:0005159	insulin-like growth factor receptor binding
0.53	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.49	GO:0031625	ubiquitin protein ligase binding
0.48	GO:0005096	GTPase activator activity
0.48	GO:0044212	transcription regulatory region DNA binding
0.47	GO:0008134	transcription factor binding
0.40	GO:0035612	AP-2 adaptor complex binding

0.54	GO:0031143	pseudopodium
0.49	GO:0016604	nuclear body
0.47	GO:0031410	cytoplasmic vesicle
0.47	GO:0000785	chromatin
0.45	GO:0005829	cytosol
0.40	GO:0005905	clathrin-coated pit
0.38	GO:0043197	dendritic spine
0.38	GO:0014069	postsynaptic density
0.38	GO:0016323	basolateral plasma membrane
0.37	GO:0045211	postsynaptic membrane

0.36

EC:2.3.1.48

GO:0004402

sp|P49411|EFTU_HUMAN
Elongation factor Tu, mitochondrial
Search

TUFM

0.44	Tu translation elongation factor, mitochondrial

0.69	GO:0006414	translational elongation
0.39	GO:0045471	response to ethanol
0.38	GO:0032543	mitochondrial translation

0.70	GO:0003746	translation elongation factor activity
0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.65	GO:0032561	guanyl ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding
0.32	GO:0008270	zinc ion binding

0.54	GO:0042645	mitochondrial nucleoid
0.54	GO:0043209	myelin sheath
0.45	GO:0031966	mitochondrial membrane
0.45	GO:0019866	organelle inner membrane
0.37	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

sp|P49418|AMPH_HUMAN
Amphiphysin
Search

AMPH

0.94	LOW QUALITY PROTEIN: amphiphysin

0.40	GO:0030100	regulation of endocytosis
0.38	GO:0048488	synaptic vesicle endocytosis
0.38	GO:0007612	learning
0.35	GO:0007268	chemical synaptic transmission
0.35	GO:0051050	positive regulation of transport
0.35	GO:0048522	positive regulation of cellular process
0.35	GO:0043547	positive regulation of GTPase activity
0.35	GO:0060988	lipid tube assembly
0.34	GO:0048710	regulation of astrocyte differentiation
0.34	GO:0051647	nucleus localization

0.53	GO:0005543	phospholipid binding
0.36	GO:0005515	protein binding
0.35	GO:0044877	macromolecular complex binding

0.57	GO:0031256	leading edge membrane
0.49	GO:0005737	cytoplasm
0.41	GO:0098793	presynapse
0.40	GO:0044306	neuron projection terminus
0.40	GO:0097708	intracellular vesicle
0.39	GO:0012506	vesicle membrane
0.39	GO:0012505	endomembrane system
0.39	GO:0030054	cell junction
0.38	GO:0098805	whole membrane
0.38	GO:0098588	bounding membrane of organelle

sp|P49419|AL7A1_HUMAN
Alpha-aminoadipic semialdehyde dehydrogenase
Search

ALDH7A1

0.83	aldehyde dehydrogenase family 7 member A1 homolog

0.56	GO:0033339	pectoral fin development
0.54	GO:0051216	cartilage development
0.53	GO:0043010	camera-type eye development
0.53	GO:0055114	oxidation-reduction process

0.69

GO:0016620

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

0.53	GO:0005829	cytosol
0.48	GO:0005739	mitochondrion

0.69

GO:0016620

sp|P49427|UB2R1_HUMAN
Ubiquitin-conjugating enzyme E2 R1
Search

CDC34

0.88	Cell division cycle 34

0.56	GO:0070936	protein K48-linked ubiquitination
0.55	GO:0043951	negative regulation of cAMP-mediated signaling
0.55	GO:0035458	cellular response to interferon-beta
0.52	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.42	GO:0051301	cell division
0.41	GO:0006513	protein monoubiquitination
0.39	GO:0090261	positive regulation of inclusion body assembly
0.38	GO:0043525	positive regulation of neuron apoptotic process
0.37	GO:0070848	response to growth factor
0.37	GO:2000403	positive regulation of lymphocyte migration

0.56	GO:0061631	ubiquitin conjugating enzyme activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0031625	ubiquitin protein ligase binding
0.45	GO:0061630	ubiquitin protein ligase activity
0.37	GO:0098640	integrin binding involved in cell-matrix adhesion

0.51	GO:0016607	nuclear speck
0.47	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|P49441|INPP_HUMAN
Inositol polyphosphate 1-phosphatase
Search

INPP1

0.96	Inositol polyphosphate 1-phosphatase

0.75	GO:0046854	phosphatidylinositol phosphorylation
0.40	GO:0043647	inositol phosphate metabolic process
0.40	GO:0016311	dephosphorylation
0.38	GO:0007268	chemical synaptic transmission
0.38	GO:0046174	polyol catabolic process
0.38	GO:0046434	organophosphate catabolic process
0.37	GO:0044262	cellular carbohydrate metabolic process
0.34	GO:0030041	actin filament polymerization
0.34	GO:0034314	Arp2/3 complex-mediated actin nucleation
0.33	GO:0007165	signal transduction

0.45	GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity
0.37	GO:0052829	inositol-1,3,4-trisphosphate 1-phosphatase activity
0.35	GO:0005515	protein binding
0.34	GO:0046872	metal ion binding
0.33	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.33	GO:0004672	protein kinase activity
0.32	GO:0052689	carboxylic ester hydrolase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.34	GO:0005829	cytosol
0.34	GO:0005885	Arp2/3 protein complex
0.32	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.45	EC:3.1.3.57	GO:0004441
0.32	KEGG:R00630	GO:0052689

sp|P49447|CY561_HUMAN
Cytochrome b561
Search

CYB561

0.85	Cytochrome b-561

0.60

GO:0022900

electron transport chain

0.85	GO:0000293	ferric-chelate reductase activity
0.36	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.48	GO:0005765	lysosomal membrane
0.40	GO:0030658	transport vesicle membrane
0.30	GO:0044425	membrane part

0.85

EC:1.16.1.7

GO:0000293

sp|P49448|DHE4_HUMAN
Glutamate dehydrogenase 2, mitochondrial
Search

GLUD1

0.45	Glutamate dehydrogenase

0.57	GO:0006520	cellular amino acid metabolic process
0.50	GO:0055114	oxidation-reduction process
0.47	GO:0032024	positive regulation of insulin secretion
0.43	GO:0072350	tricarboxylic acid metabolic process
0.42	GO:0043649	dicarboxylic acid catabolic process
0.40	GO:0032094	response to food
0.39	GO:0043650	dicarboxylic acid biosynthetic process
0.39	GO:1901565	organonitrogen compound catabolic process
0.38	GO:0021762	substantia nigra development
0.37	GO:0010044	response to aluminum ion

0.71	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
0.44	GO:0070728	leucine binding
0.40	GO:0043531	ADP binding
0.39	GO:0032550	purine ribonucleoside binding
0.39	GO:0019001	guanyl nucleotide binding
0.38	GO:0070403	NAD+ binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0005515	protein binding
0.35	GO:0008144	drug binding

0.46	GO:0005759	mitochondrial matrix
0.39	GO:0031966	mitochondrial membrane
0.39	GO:0019866	organelle inner membrane

0.71

EC:1.4.1

GO:0016639

sp|P49450|CENPA_HUMAN
Histone H3-like centromeric protein A
Search

CENPA

0.74	Centromere protein A

0.55	GO:0061641	CENP-A containing chromatin organization
0.52	GO:0051382	kinetochore assembly
0.52	GO:0000132	establishment of mitotic spindle orientation
0.52	GO:0071459	protein localization to chromosome, centromeric region
0.50	GO:0000281	mitotic cytokinesis
0.47	GO:0006334	nucleosome assembly
0.37	GO:0000819	sister chromatid segregation
0.36	GO:0031055	chromatin remodeling at centromere
0.36	GO:0034724	DNA replication-independent nucleosome organization
0.36	GO:0043486	histone exchange

0.74	GO:0046982	protein heterodimerization activity
0.55	GO:0003677	DNA binding
0.48	GO:0031491	nucleosome binding

0.75	GO:0000786	nucleosome
0.61	GO:0005634	nucleus
0.59	GO:0000779	condensed chromosome, centromeric region
0.55	GO:0061638	CENP-A containing chromatin
0.51	GO:0005721	pericentric heterochromatin
0.51	GO:0043233	organelle lumen
0.50	GO:0000776	kinetochore
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|P49454|CENPF_HUMAN
Centromere protein F
Search

0.52	Centromere protein F

0.63	GO:0021591	ventricular system development
0.61	GO:0051310	metaphase plate congression
0.60	GO:0016202	regulation of striated muscle tissue development
0.59	GO:0001822	kidney development
0.59	GO:0010389	regulation of G2/M transition of mitotic cell cycle
0.56	GO:0000278	mitotic cell cycle
0.54	GO:0045892	negative regulation of transcription, DNA-templated
0.50	GO:0008104	protein localization
0.49	GO:0042886	amide transport
0.47	GO:0071702	organic substance transport

0.82	GO:0070840	dynein complex binding
0.73	GO:0042803	protein homodimerization activity
0.71	GO:0008134	transcription factor binding
0.60	GO:0008022	protein C-terminus binding
0.35	GO:0051015	actin filament binding
0.34	GO:0003735	structural constituent of ribosome
0.34	GO:0003682	chromatin binding

0.62	GO:0097539	ciliary transition fiber
0.61	GO:0045120	pronucleus
0.61	GO:0016363	nuclear matrix
0.59	GO:0030496	midbody
0.59	GO:0000940	condensed chromosome outer kinetochore
0.58	GO:0000922	spindle pole
0.58	GO:0036064	ciliary basal body
0.58	GO:0005930	axoneme
0.56	GO:0005635	nuclear envelope
0.55	GO:0005813	centrosome

sp|P49458|SRP09_HUMAN
Signal recognition particle 9 kDa protein
Search

SRP9

0.90	Signal recognition particle 9

0.79	GO:0045900	negative regulation of translational elongation
0.75	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.44	GO:0065002	intracellular protein transmembrane transport

0.77	GO:0008312	7S RNA binding
0.48	GO:0005047	signal recognition particle binding
0.33	GO:0005515	protein binding
0.32	GO:0016787	hydrolase activity

0.76	GO:0048500	signal recognition particle
0.48	GO:0005785	signal recognition particle receptor complex
0.37	GO:0070062	extracellular exosome
0.35	GO:0005829	cytosol

0.32

GO:0016787

sp|P49459|UBE2A_HUMAN
Ubiquitin-conjugating enzyme E2 A
Search

UBE2A

0.61	Ubiquitin-conjugating enzyme

0.56	GO:0070979	protein K11-linked ubiquitination
0.56	GO:0033522	histone H2A ubiquitination
0.55	GO:0070936	protein K48-linked ubiquitination
0.55	GO:0051865	protein autoubiquitination
0.53	GO:0009411	response to UV
0.51	GO:0001701	in utero embryonic development
0.49	GO:0060135	maternal process involved in female pregnancy
0.49	GO:0008284	positive regulation of cell proliferation
0.48	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.46	GO:0006281	DNA repair

0.56	GO:0061631	ubiquitin conjugating enzyme activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0031625	ubiquitin protein ligase binding
0.45	GO:0061630	ubiquitin protein ligase activity
0.34	GO:0043130	ubiquitin binding

0.58	GO:0033503	HULC complex
0.55	GO:0001741	XY body
0.51	GO:0000790	nuclear chromatin
0.40	GO:0005657	replication fork
0.37	GO:0005737	cytoplasm
0.33	GO:0005654	nucleoplasm
0.33	GO:0005886	plasma membrane

sp|P49585|PCY1A_HUMAN
Choline-phosphate cytidylyltransferase A
Search

PCYT1A

0.97	Choline-phosphate cytidylyltransferase A

0.53	GO:0006656	phosphatidylcholine biosynthetic process
0.34	GO:0001541	ovarian follicle development
0.34	GO:0007283	spermatogenesis

0.55	GO:0016779	nucleotidyltransferase activity
0.38	GO:0031210	phosphatidylcholine binding
0.37	GO:0005516	calmodulin binding
0.36	GO:0042803	protein homodimerization activity

0.56	GO:0042587	glycogen granule
0.47	GO:0005789	endoplasmic reticulum membrane
0.37	GO:0005635	nuclear envelope
0.36	GO:0005829	cytosol
0.34	GO:0019898	extrinsic component of membrane
0.34	GO:0005886	plasma membrane

0.55

GO:0016779

sp|P49588|SYAC_HUMAN
Alanine--tRNA ligase, cytoplasmic
Search

AARS

0.61	LOW QUALITY PROTEIN: alanine--tRNA ligase, cytoplasmic

0.78	GO:0006419	alanyl-tRNA aminoacylation
0.55	GO:0021680	cerebellar Purkinje cell layer development
0.54	GO:0050885	neuromuscular process controlling balance
0.53	GO:0043524	negative regulation of neuron apoptotic process
0.51	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity
0.48	GO:0006400	tRNA modification
0.36	GO:0140018	regulation of cytoplasmic translational fidelity
0.33	GO:0006414	translational elongation
0.32	GO:0006413	translational initiation

0.78	GO:0004813	alanine-tRNA ligase activity
0.65	GO:0000049	tRNA binding
0.59	GO:0008270	zinc ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0002161	aminoacyl-tRNA editing activity
0.45	GO:0016597	amino acid binding
0.34	GO:0008135	translation factor activity, RNA binding
0.33	GO:0005515	protein binding

0.48	GO:0005737	cytoplasm
0.39	GO:0043231	intracellular membrane-bounded organelle
0.36	GO:0070062	extracellular exosome
0.32	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.78

EC:6.1.1.7

GO:0004813

sp|P49589|SYCC_HUMAN
Cysteine--tRNA ligase, cytoplasmic
Search

CARS

0.70	Cysteinyl-tRNA synthetase

0.78	GO:0006423	cysteinyl-tRNA aminoacylation
0.34	GO:0006869	lipid transport
0.33	GO:0007165	signal transduction

0.78	GO:0004817	cysteine-tRNA ligase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0042803	protein homodimerization activity
0.46	GO:0000049	tRNA binding
0.35	GO:0046872	metal ion binding

0.46	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.78

EC:6.1.1.16

GO:0004817

sp|P49590|SYHM_HUMAN
Probable histidine--tRNA ligase, mitochondrial
Search

HARS2

0.66	Histidine--tRNA ligase mitochondrial

0.74	GO:0006427	histidyl-tRNA aminoacylation
0.49	GO:0032543	mitochondrial translation

0.74	GO:0004821	histidine-tRNA ligase activity
0.54	GO:0042802	identical protein binding
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0046983	protein dimerization activity
0.35	GO:0008270	zinc ion binding
0.35	GO:0003723	RNA binding

0.49	GO:0005737	cytoplasm
0.43	GO:0043231	intracellular membrane-bounded organelle
0.37	GO:0031974	membrane-enclosed lumen
0.35	GO:0044446	intracellular organelle part

0.74

EC:6.1.1.21

GO:0004821

sp|P49591|SYSC_HUMAN
Serine--tRNA ligase, cytoplasmic
Search

SARS

0.60	LOW QUALITY PROTEIN: serine--tRNA ligase, cytoplasmic

0.79	GO:0006434	seryl-tRNA aminoacylation
0.47	GO:1904046	negative regulation of vascular endothelial growth factor production
0.43	GO:0016525	negative regulation of angiogenesis
0.42	GO:0000122	negative regulation of transcription by RNA polymerase II
0.42	GO:0097056	selenocysteinyl-tRNA(Sec) biosynthetic process
0.35	GO:0001569	branching involved in blood vessel morphogenesis
0.35	GO:1903670	regulation of sprouting angiogenesis
0.34	GO:0016259	selenocysteine metabolic process
0.33	GO:0008033	tRNA processing
0.33	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

0.79	GO:0004828	serine-tRNA ligase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0001046	core promoter sequence-specific DNA binding
0.37	GO:0042803	protein homodimerization activity
0.36	GO:0098619	selenocysteine-tRNA ligase activity
0.33	GO:0003723	RNA binding
0.33	GO:0005509	calcium ion binding

0.49	GO:0005737	cytoplasm
0.38	GO:0005634	nucleus
0.36	GO:0070062	extracellular exosome
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.79

EC:6.1.1.11

GO:0004828

sp|P49593|PPM1F_HUMAN
Protein phosphatase 1F
Search

PPM1F

0.89	Protein phosphatase 1F (PP2C domain containing)

0.66	GO:0006470	protein dephosphorylation
0.62	GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
0.61	GO:0051894	positive regulation of focal adhesion assembly
0.61	GO:0033137	negative regulation of peptidyl-serine phosphorylation
0.58	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.58	GO:0010634	positive regulation of epithelial cell migration
0.58	GO:0050921	positive regulation of chemotaxis
0.58	GO:0051496	positive regulation of stress fiber assembly
0.58	GO:0097193	intrinsic apoptotic signaling pathway
0.57	GO:0045927	positive regulation of growth

0.70	GO:0004722	protein serine/threonine phosphatase activity
0.50	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.50	GO:0005829	cytosol
0.45	GO:0043234	protein complex
0.38	GO:0048471	perinuclear region of cytoplasm

sp|P49619|DGKG_HUMAN
Diacylglycerol kinase gamma
Search

DGKG

0.47	Diacylglycerol kinase gamma

0.83	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
0.62	GO:0035556	intracellular signal transduction
0.57	GO:0016310	phosphorylation
0.52	GO:0030258	lipid modification
0.51	GO:0046486	glycerolipid metabolic process
0.39	GO:0048666	neuron development
0.36	GO:0030168	platelet activation
0.33	GO:2001141	regulation of RNA biosynthetic process
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression

0.80	GO:0004143	diacylglycerol kinase activity
0.75	GO:0003951	NAD+ kinase activity
0.69	GO:0005509	calcium ion binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0043565	sequence-specific DNA binding
0.34	GO:0003700	DNA binding transcription factor activity

0.45	GO:0005622	intracellular
0.35	GO:0005886	plasma membrane
0.33	GO:0043227	membrane-bounded organelle

0.80	EC:2.7.1.107	GO:0004143
0.75	KEGG:R00104	GO:0003951

sp|P49638|TTPA_HUMAN
Alpha-tocopherol transfer protein
Search

TTPA

0.72	Gamma-glutamyl hydrolase

0.85	GO:0090212	negative regulation of establishment of blood-brain barrier
0.81	GO:0042360	vitamin E metabolic process
0.75	GO:0120009	intermembrane lipid transfer
0.74	GO:0043009	chordate embryonic development
0.67	GO:0001890	placenta development
0.67	GO:0051180	vitamin transport
0.64	GO:0048568	embryonic organ development
0.61	GO:0009636	response to toxic substance
0.57	GO:0007417	central nervous system development
0.55	GO:0051452	intracellular pH reduction

0.84	GO:0008431	vitamin E binding
0.79	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
0.76	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.75	GO:0120013	intermembrane lipid transfer activity
0.38	GO:0005515	protein binding
0.37	GO:0034722	gamma-glutamyl-peptidase activity
0.33	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors

0.53	GO:0005770	late endosome
0.47	GO:0005829	cytosol
0.35	GO:0005773	vacuole
0.35	GO:0005615	extracellular space
0.30	GO:0016020	membrane

0.37

EC:3.4.19.9

GO:0034722

sp|P49639|HXA1_HUMAN
Homeobox protein Hox-A1
Search

HOXA1

0.97	Homeobox protein Hox-A1

0.64	GO:0021598	abducens nerve morphogenesis
0.63	GO:0060876	semicircular canal formation
0.62	GO:0042473	outer ear morphogenesis
0.62	GO:0007634	optokinetic behavior
0.62	GO:0021603	cranial nerve formation
0.62	GO:0048702	embryonic neurocranium morphogenesis
0.61	GO:0090103	cochlea morphogenesis
0.60	GO:0048844	artery morphogenesis
0.59	GO:0050905	neuromuscular process
0.58	GO:0050795	regulation of behavior

0.63	GO:0043565	sequence-specific DNA binding
0.53	GO:0042802	identical protein binding
0.35	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding

0.60	GO:0005634	nucleus
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part

sp|P49640|EVX1_HUMAN
Homeobox even-skipped homolog protein 1
Search

EVX1

0.97	Homeobox even-skipped like protein 1

0.63	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
0.55	GO:0009792	embryo development ending in birth or egg hatching
0.54	GO:0045944	positive regulation of transcription by RNA polymerase II
0.47	GO:0035107	appendage morphogenesis
0.46	GO:0060173	limb development
0.38	GO:0033333	fin development
0.33	GO:0006351	transcription, DNA-templated

0.63	GO:0043565	sequence-specific DNA binding
0.34	GO:0003700	DNA binding transcription factor activity

0.61	GO:0005634	nucleus
0.49	GO:0031974	membrane-enclosed lumen
0.44	GO:0044446	intracellular organelle part

sp|P49641|MA2A2_HUMAN
Alpha-mannosidase 2x
Search

MAN2A2

0.47	Alpha-mannosidase

0.81	GO:0006013	mannose metabolic process
0.49	GO:0006517	protein deglycosylation
0.49	GO:0006491	N-glycan processing
0.38	GO:0007585	respiratory gaseous exchange
0.38	GO:0048286	lung alveolus development
0.37	GO:0060042	retina morphogenesis in camera-type eye
0.37	GO:0001889	liver development
0.37	GO:0001701	in utero embryonic development
0.37	GO:0050769	positive regulation of neurogenesis
0.37	GO:0007033	vacuole organization

0.79	GO:0004559	alpha-mannosidase activity
0.70	GO:0030246	carbohydrate binding
0.53	GO:0046872	metal ion binding
0.50	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds
0.35	GO:0004713	protein tyrosine kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.46	GO:0098791	Golgi subcompartment
0.44	GO:0098588	bounding membrane of organelle
0.37	GO:0005801	cis-Golgi network
0.36	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane

0.79

EC:3.2.1.24

GO:0004559

sp|P49642|PRI1_HUMAN
DNA primase small subunit
Search

PRIM1

0.47	DNA primase small subunit

0.74	GO:0006269	DNA replication, synthesis of RNA primer
0.36	GO:0032201	telomere maintenance via semi-conservative replication
0.35	GO:0000082	G1/S transition of mitotic cell cycle
0.35	GO:0006270	DNA replication initiation
0.32	GO:0035556	intracellular signal transduction

0.77	GO:0003896	DNA primase activity
0.47	GO:0003697	single-stranded DNA binding
0.33	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.52	GO:0005658	alpha DNA polymerase:primase complex
0.34	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.77

GO:0003896

sp|P49643|PRI2_HUMAN
DNA primase large subunit
Search

PRIM2

0.72	DNA primase large subunit

0.73	GO:0006269	DNA replication, synthesis of RNA primer
0.44	GO:0071897	DNA biosynthetic process
0.37	GO:0032201	telomere maintenance via semi-conservative replication
0.36	GO:0000082	G1/S transition of mitotic cell cycle
0.35	GO:0006270	DNA replication initiation

0.75	GO:0003896	DNA primase activity
0.63	GO:0051539	4 iron, 4 sulfur cluster binding
0.51	GO:0046872	metal ion binding
0.50	GO:0003677	DNA binding
0.45	GO:0003887	DNA-directed DNA polymerase activity
0.35	GO:0005515	protein binding

0.51	GO:0005658	alpha DNA polymerase:primase complex
0.34	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.75

GO:0003896

sp|P49662|CASP4_HUMAN
Caspase-4
Search

0.87	Caspase-1/caspase-4 hybrid

0.68	GO:0042981	regulation of apoptotic process
0.61	GO:0006508	proteolysis
0.58	GO:0012501	programmed cell death
0.55	GO:0050727	regulation of inflammatory response
0.55	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway
0.51	GO:0050718	positive regulation of interleukin-1 beta secretion
0.50	GO:0071310	cellular response to organic substance
0.50	GO:0034976	response to endoplasmic reticulum stress
0.49	GO:1904645	response to amyloid-beta
0.47	GO:1901701	cellular response to oxygen-containing compound

0.75	GO:0004197	cysteine-type endopeptidase activity
0.54	GO:0050700	CARD domain binding
0.41	GO:0019900	kinase binding
0.40	GO:0042802	identical protein binding
0.40	GO:0097110	scaffold protein binding
0.35	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
0.34	GO:0002020	protease binding

0.62	GO:0061702	inflammasome complex
0.47	GO:0005783	endoplasmic reticulum
0.45	GO:0097179	protease inhibitor complex
0.42	GO:0005739	mitochondrion
0.40	GO:0005576	extracellular region
0.38	GO:0043005	neuron projection
0.38	GO:0043025	neuronal cell body
0.38	GO:0005886	plasma membrane
0.37	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0031984	organelle subcompartment

0.75

GO:0004197

sp|P49674|KC1E_HUMAN
Casein kinase I isoform epsilon
Search

CSNK1E

0.76	Casein kinase I epsilon

0.63	GO:0006468	protein phosphorylation
0.57	GO:2000052	positive regulation of non-canonical Wnt signaling pathway
0.55	GO:0032922	circadian regulation of gene expression
0.55	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.54	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.54	GO:0042752	regulation of circadian rhythm
0.53	GO:0030178	negative regulation of Wnt signaling pathway
0.51	GO:1903827	regulation of cellular protein localization
0.47	GO:0034613	cellular protein localization
0.46	GO:0018209	peptidyl-serine modification

0.65	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0003723	RNA binding
0.34	GO:0005515	protein binding

0.45	GO:0005634	nucleus
0.44	GO:0030529	intracellular ribonucleoprotein complex
0.38	GO:0030426	growth cone
0.38	GO:0043025	neuronal cell body
0.36	GO:0005737	cytoplasm
0.34	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part
0.33	GO:0098588	bounding membrane of organelle
0.33	GO:0012505	endomembrane system
0.30	GO:0031224	intrinsic component of membrane

0.65

GO:0004674

sp|P49675|STAR_HUMAN
Steroidogenic acute regulatory protein, mitochondrial
Search

STAR

0.95	Steroidogenic acute regulatory protein, mitochondrial

0.82	GO:0030301	cholesterol transport
0.75	GO:0006694	steroid biosynthetic process
0.64	GO:1904253	positive regulation of bile acid metabolic process
0.62	GO:0070857	regulation of bile acid biosynthetic process
0.62	GO:0008211	glucocorticoid metabolic process
0.62	GO:0010893	positive regulation of steroid biosynthetic process
0.52	GO:0031328	positive regulation of cellular biosynthetic process
0.48	GO:0044255	cellular lipid metabolic process
0.46	GO:0008203	cholesterol metabolic process
0.41	GO:0042747	circadian sleep/wake cycle, REM sleep

0.84	GO:0017127	cholesterol transporter activity
0.81	GO:0015485	cholesterol binding
0.35	GO:0005515	protein binding

0.59	GO:0005739	mitochondrion
0.38	GO:0043025	neuronal cell body
0.38	GO:0031970	organelle envelope lumen
0.38	GO:0043005	neuron projection
0.36	GO:0005829	cytosol
0.35	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

sp|P49682|CXCR3_HUMAN
C-X-C chemokine receptor type 3
Search

CXCR3

0.96	LOW QUALITY PROTEIN: C-X-C chemokine receptor type 3

0.80	GO:0070098	chemokine-mediated signaling pathway
0.71	GO:0002685	regulation of leukocyte migration
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.70	GO:0006954	inflammatory response
0.68	GO:0006935	chemotaxis
0.46	GO:0071954	chemokine (C-C motif) ligand 11 production
0.45	GO:0002376	immune system process
0.44	GO:1900118	negative regulation of execution phase of apoptosis
0.44	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
0.43	GO:0048731	system development

0.81	GO:0004950	chemokine receptor activity
0.60	GO:0019956	chemokine binding
0.42	GO:0005044	scavenger receptor activity
0.36	GO:0004878	complement component C5a receptor activity
0.35	GO:0008188	neuropeptide receptor activity
0.34	GO:0015026	coreceptor activity
0.33	GO:0042277	peptide binding
0.33	GO:0004947	bradykinin receptor activity
0.32	GO:0003924	GTPase activity
0.32	GO:0005525	GTP binding

0.52	GO:0009897	external side of plasma membrane
0.38	GO:0005887	integral component of plasma membrane
0.35	GO:0005884	actin filament
0.35	GO:0031965	nuclear membrane
0.34	GO:0005654	nucleoplasm
0.34	GO:0005829	cytosol
0.34	GO:0009925	basal plasma membrane
0.33	GO:0045177	apical part of cell
0.32	GO:0043005	neuron projection

sp|P49683|PRLHR_HUMAN
Prolactin-releasing peptide receptor
Search

PRLHR

0.96	Prolactin-releasing peptide receptor

0.80	GO:0007218	neuropeptide signaling pathway
0.57	GO:0007631	feeding behavior
0.50	GO:0042445	hormone metabolic process
0.47	GO:0098916	anterograde trans-synaptic signaling
0.36	GO:0007565	female pregnancy
0.33	GO:0008015	blood circulation

0.84	GO:0004983	neuropeptide Y receptor activity
0.36	GO:0017046	peptide hormone binding
0.34	GO:0005515	protein binding

0.35	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

sp|P49685|GPR15_HUMAN
G-protein coupled receptor 15
Search

GPR15

0.66	G-protein coupled receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.60	GO:0072678	T cell migration
0.50	GO:0051806	entry into cell of other organism involved in symbiotic interaction
0.50	GO:0044409	entry into host
0.48	GO:0019058	viral life cycle
0.44	GO:0071310	cellular response to organic substance
0.42	GO:1990776	response to angiotensin
0.42	GO:0034097	response to cytokine
0.42	GO:0007166	cell surface receptor signaling pathway
0.41	GO:0097746	regulation of blood vessel diameter

0.72	GO:0004930	G-protein coupled receptor activity
0.62	GO:0001618	virus receptor activity
0.60	GO:0015026	coreceptor activity
0.47	GO:0001653	peptide receptor activity
0.43	GO:0004896	cytokine receptor activity
0.35	GO:0042923	neuropeptide binding
0.34	GO:0005515	protein binding
0.33	GO:0004878	complement component C5a receptor activity
0.33	GO:0016500	protein-hormone receptor activity

0.54	GO:0005768	endosome
0.45	GO:0005886	plasma membrane
0.35	GO:0009986	cell surface
0.35	GO:0098552	side of membrane
0.34	GO:0043005	neuron projection
0.30	GO:0016021	integral component of membrane

sp|P49703|ARL4D_HUMAN
ADP-ribosylation factor-like protein 4D
Search

ARL4D

0.97	Neuroprotective protein 2

0.34

GO:0009306

protein secretion

0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032553	ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0003924	GTPase activity
0.33	GO:0005515	protein binding

0.45	GO:0005622	intracellular
0.43	GO:0032154	cleavage furrow
0.42	GO:0005886	plasma membrane
0.41	GO:0043227	membrane-bounded organelle
0.37	GO:0031974	membrane-enclosed lumen
0.35	GO:0043228	non-membrane-bounded organelle
0.35	GO:0044422	organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|P49711|CTCF_HUMAN
Transcriptional repressor CTCF
Search

CTCF

0.85	Transcriptional repressor CTCF

0.47	GO:0040030	regulation of molecular function, epigenetic
0.46	GO:0010216	maintenance of DNA methylation
0.46	GO:0006349	regulation of gene expression by genetic imprinting
0.45	GO:0016584	nucleosome positioning
0.45	GO:0071459	protein localization to chromosome, centromeric region
0.44	GO:0031060	regulation of histone methylation
0.44	GO:0035065	regulation of histone acetylation
0.43	GO:0008285	negative regulation of cell proliferation
0.43	GO:0000122	negative regulation of transcription by RNA polymerase II
0.42	GO:0006366	transcription by RNA polymerase II

0.51	GO:0003676	nucleic acid binding
0.44	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.43	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.43	GO:0003682	chromatin binding
0.37	GO:0005515	protein binding
0.36	GO:0003714	transcription corepressor activity
0.36	GO:0046872	metal ion binding

0.42	GO:0000775	chromosome, centromeric region
0.42	GO:0000793	condensed chromosome
0.41	GO:0005730	nucleolus
0.41	GO:0005654	nucleoplasm

sp|P49715|CEBPA_HUMAN
CCAAT/enhancer-binding protein alpha
Search

CEBPA

0.81	CCAAT/enhancer-binding protein epsilon

0.62	GO:0030851	granulocyte differentiation
0.59	GO:0030225	macrophage differentiation
0.59	GO:0001889	liver development
0.57	GO:0045600	positive regulation of fat cell differentiation
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:0045669	positive regulation of osteoblast differentiation
0.57	GO:0045444	fat cell differentiation
0.56	GO:0010468	regulation of gene expression
0.55	GO:0006366	transcription by RNA polymerase II

0.61	GO:0003700	DNA binding transcription factor activity
0.56	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.55	GO:0000987	proximal promoter sequence-specific DNA binding
0.53	GO:0019900	kinase binding
0.52	GO:0042803	protein homodimerization activity
0.51	GO:0003713	transcription coactivator activity
0.48	GO:0008134	transcription factor binding
0.45	GO:0042826	histone deacetylase binding
0.44	GO:0035035	histone acetyltransferase binding
0.43	GO:0001046	core promoter sequence-specific DNA binding

0.51	GO:0005654	nucleoplasm
0.50	GO:0090575	RNA polymerase II transcription factor complex
0.45	GO:0016363	nuclear matrix
0.42	GO:0000779	condensed chromosome, centromeric region
0.41	GO:0000790	nuclear chromatin
0.40	GO:0005730	nucleolus
0.35	GO:0005737	cytoplasm
0.32	GO:0005886	plasma membrane

sp|P49716|CEBPD_HUMAN
CCAAT/enhancer-binding protein delta
Search

CEBPD

0.95	CCAAT-enhancer binding protein delta

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0030097	hemopoiesis
0.56	GO:0010468	regulation of gene expression
0.55	GO:0006366	transcription by RNA polymerase II
0.55	GO:0045669	positive regulation of osteoblast differentiation
0.54	GO:0045444	fat cell differentiation
0.54	GO:0051254	positive regulation of RNA metabolic process
0.53	GO:0010557	positive regulation of macromolecule biosynthetic process
0.53	GO:0031328	positive regulation of cellular biosynthetic process

0.61	GO:0003700	DNA binding transcription factor activity
0.58	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.50	GO:0042803	protein homodimerization activity
0.48	GO:0046982	protein heterodimerization activity
0.41	GO:0003713	transcription coactivator activity
0.41	GO:0019900	kinase binding
0.39	GO:0008134	transcription factor binding
0.35	GO:0001013	RNA polymerase I regulatory region DNA binding
0.34	GO:0004677	DNA-dependent protein kinase activity
0.33	GO:0071837	HMG box domain binding

0.52	GO:0005654	nucleoplasm
0.40	GO:0090575	RNA polymerase II transcription factor complex
0.34	GO:0005730	nucleolus
0.33	GO:0016363	nuclear matrix
0.30	GO:0016020	membrane

0.34

GO:0004677

sp|P49720|PSB3_HUMAN
Proteasome subunit beta type-3
Search

PSMB3

0.53	Proteasome subunit beta type

0.77	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.35	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:1902036	regulation of hematopoietic stem cell differentiation
0.35	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
0.35	GO:0070498	interleukin-1-mediated signaling pathway
0.35	GO:0038061	NIK/NF-kappaB signaling

0.76	GO:0070003	threonine-type peptidase activity
0.64	GO:0004175	endopeptidase activity
0.33	GO:0005515	protein binding

0.81	GO:0019774	proteasome core complex, beta-subunit complex
0.58	GO:0005634	nucleus
0.46	GO:0005737	cytoplasm
0.36	GO:0070062	extracellular exosome
0.35	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part

sp|P49721|PSB2_HUMAN
Proteasome subunit beta type-2
Search

PSMB2

0.53	Proteasome subunit beta type

0.71	GO:0051603	proteolysis involved in cellular protein catabolic process
0.38	GO:0010243	response to organonitrogen compound
0.38	GO:0014070	response to organic cyclic compound
0.36	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.36	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.35	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:1902036	regulation of hematopoietic stem cell differentiation
0.35	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia

0.76	GO:0070003	threonine-type peptidase activity
0.64	GO:0004175	endopeptidase activity
0.33	GO:0005515	protein binding

0.74	GO:0005839	proteasome core complex
0.56	GO:0005634	nucleus
0.48	GO:0031974	membrane-enclosed lumen
0.45	GO:0005737	cytoplasm
0.43	GO:0044446	intracellular organelle part
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

sp|P49736|MCM2_HUMAN
DNA replication licensing factor MCM2
Search

MCM2

0.44	DNA helicase

0.74	GO:0006270	DNA replication initiation
0.69	GO:0032392	DNA geometric change
0.55	GO:0071353	cellular response to interleukin-4
0.55	GO:0007423	sensory organ development
0.51	GO:0006334	nucleosome assembly
0.50	GO:0006915	apoptotic process
0.48	GO:0048538	thymus development

0.69	GO:0003678	DNA helicase activity
0.54	GO:0030554	adenyl nucleotide binding
0.54	GO:0003677	DNA binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0042393	histone binding
0.48	GO:0019899	enzyme binding
0.45	GO:0003682	chromatin binding
0.34	GO:0008270	zinc ion binding

0.78	GO:0042555	MCM complex
0.60	GO:0005634	nucleus
0.52	GO:0000808	origin recognition complex
0.48	GO:0000785	chromatin
0.47	GO:0015630	microtubule cytoskeleton
0.46	GO:0031974	membrane-enclosed lumen
0.38	GO:0005737	cytoplasm
0.34	GO:0000781	chromosome, telomeric region
0.30	GO:0016020	membrane

sp|P49746|TSP3_HUMAN
Thrombospondin-3
Search

THBS3

0.91	Thrombospondin-3

0.81	GO:0030198	extracellular matrix organization
0.72	GO:0007155	cell adhesion
0.58	GO:0060346	bone trabecula formation
0.57	GO:0043931	ossification involved in bone maturation
0.57	GO:0003417	growth plate cartilage development
0.41	GO:0051451	myoblast migration
0.41	GO:0048266	behavioral response to pain
0.41	GO:0090023	positive regulation of neutrophil chemotaxis
0.41	GO:0034103	regulation of tissue remodeling
0.40	GO:0001938	positive regulation of endothelial cell proliferation

0.78	GO:0008201	heparin binding
0.70	GO:0005509	calcium ion binding
0.40	GO:0005178	integrin binding

0.74	GO:0031012	extracellular matrix
0.53	GO:0048471	perinuclear region of cytoplasm
0.40	GO:0016529	sarcoplasmic reticulum
0.38	GO:0005615	extracellular space
0.30	GO:0016020	membrane

sp|P49747|COMP_HUMAN
Cartilage oligomeric matrix protein
Search

COMP

0.63	Cartilage oligomeric matrix protein variant (Fragment)

0.81	GO:0030198	extracellular matrix organization
0.72	GO:0007155	cell adhesion
0.51	GO:0051451	myoblast migration
0.51	GO:0048266	behavioral response to pain
0.50	GO:0090023	positive regulation of neutrophil chemotaxis
0.49	GO:0034103	regulation of tissue remodeling
0.49	GO:0001938	positive regulation of endothelial cell proliferation
0.49	GO:0003417	growth plate cartilage development
0.49	GO:0016525	negative regulation of angiogenesis
0.48	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation

0.70	GO:0005509	calcium ion binding
0.55	GO:0008201	heparin binding
0.51	GO:0032403	protein complex binding
0.49	GO:0043395	heparan sulfate proteoglycan binding
0.48	GO:0002020	protease binding
0.47	GO:0050839	cell adhesion molecule binding
0.45	GO:0005102	receptor binding
0.37	GO:0030545	receptor regulator activity
0.34	GO:0001968	fibronectin binding
0.34	GO:0043237	laminin-1 binding

0.74	GO:0031012	extracellular matrix
0.50	GO:0005615	extracellular space
0.49	GO:0016529	sarcoplasmic reticulum
0.35	GO:1903561	extracellular vesicle
0.34	GO:0031594	neuromuscular junction

sp|P49748|ACADV_HUMAN
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Search

ACADVL

0.95	Very long-chain specific acyl-CoA dehydrogenaseserine-threonine

0.57	GO:0046322	negative regulation of fatty acid oxidation
0.56	GO:0090181	regulation of cholesterol metabolic process
0.55	GO:0001659	temperature homeostasis
0.54	GO:0045717	negative regulation of fatty acid biosynthetic process
0.54	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
0.52	GO:0030855	epithelial cell differentiation
0.52	GO:0009409	response to cold
0.43	GO:0060322	head development
0.36	GO:0036498	IRE1-mediated unfolded protein response
0.35	GO:0042760	very long-chain fatty acid catabolic process

0.74	GO:0003995	acyl-CoA dehydrogenase activity
0.66	GO:0050660	flavin adenine dinucleotide binding
0.35	GO:0000062	fatty-acyl-CoA binding
0.33	GO:0008289	lipid binding
0.32	GO:0003677	DNA binding

0.54	GO:0042645	mitochondrial nucleoid
0.49	GO:0005730	nucleolus
0.47	GO:0005829	cytosol
0.45	GO:0031966	mitochondrial membrane
0.36	GO:0019866	organelle inner membrane
0.34	GO:0036128	CatSper complex

0.74

EC:1.3.99.3

GO:0003995

sp|P49750|YLPM1_HUMAN
YLP motif-containing protein 1
Search

YLPM1

0.94	YLP motif-containing protein 1

0.34	GO:0006351	transcription, DNA-templated
0.34	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression

0.35	GO:0005515	protein binding
0.34	GO:0003723	RNA binding
0.34	GO:0005199	structural constituent of cell wall

0.61	GO:0005634	nucleus
0.53	GO:0005829	cytosol
0.52	GO:0031974	membrane-enclosed lumen
0.46	GO:0044446	intracellular organelle part
0.35	GO:0032040	small-subunit processome

sp|P49753|ACOT2_HUMAN
Acyl-coenzyme A thioesterase 2, mitochondrial
Search

0.54	Acyl-coenzyme A thioesterase 2, mitochondrial

0.73	GO:0035383	thioester metabolic process
0.65	GO:0032789	unsaturated monocarboxylic acid metabolic process
0.65	GO:0032788	saturated monocarboxylic acid metabolic process
0.63	GO:0006732	coenzyme metabolic process
0.61	GO:0000038	very long-chain fatty acid metabolic process
0.59	GO:0001676	long-chain fatty acid metabolic process
0.54	GO:0006793	phosphorus metabolic process
0.53	GO:0043649	dicarboxylic acid catabolic process
0.53	GO:0046459	short-chain fatty acid metabolic process
0.38	GO:0070849	response to epidermal growth factor

0.76	GO:0016790	thiolester hydrolase activity
0.52	GO:0005102	receptor binding
0.47	GO:0052689	carboxylic ester hydrolase activity

0.55	GO:0005777	peroxisome
0.42	GO:0005829	cytosol
0.41	GO:0005759	mitochondrial matrix
0.40	GO:0070062	extracellular exosome
0.37	GO:0031907	microbody lumen

0.76	EC:3.1.2	GO:0016790
0.47	KEGG:R00630	GO:0052689

sp|P49754|VPS41_HUMAN
Vacuolar protein sorting-associated protein 41 homolog
Search

VPS41

0.90	Vacuolar protein sorting-associated protein 41

0.68	GO:0006886	intracellular protein transport
0.68	GO:0016192	vesicle-mediated transport
0.58	GO:1902774	late endosome to lysosome transport
0.54	GO:0048284	organelle fusion
0.51	GO:0016050	vesicle organization
0.51	GO:0016197	endosomal transport
0.49	GO:0035542	regulation of SNARE complex assembly
0.49	GO:0061025	membrane fusion
0.48	GO:0072666	establishment of protein localization to vacuole
0.47	GO:0007033	vacuole organization

0.49	GO:0042802	identical protein binding
0.49	GO:0008017	microtubule binding
0.45	GO:0051020	GTPase binding
0.38	GO:0043621	protein self-association
0.33	GO:0046872	metal ion binding

0.58	GO:0030897	HOPS complex
0.54	GO:0005770	late endosome
0.54	GO:0071439	clathrin complex
0.53	GO:0005765	lysosomal membrane
0.53	GO:0044440	endosomal part
0.53	GO:0030123	AP-3 adaptor complex
0.52	GO:0005769	early endosome
0.51	GO:0030136	clathrin-coated vesicle
0.48	GO:0015630	microtubule cytoskeleton
0.37	GO:0005798	Golgi-associated vesicle

sp|P49755|TMEDA_HUMAN
Transmembrane emp24 domain-containing protein 10
Search

TMED10

0.96	Transmembrane emp24 domain-containing protein 10

0.62	GO:0035964	COPI-coated vesicle budding
0.61	GO:1902003	regulation of amyloid-beta formation
0.55	GO:0045055	regulated exocytosis
0.55	GO:0007030	Golgi organization
0.49	GO:0006886	intracellular protein transport
0.43	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.40	GO:0043279	response to alkaloid
0.39	GO:0001822	kidney development
0.38	GO:0051259	protein oligomerization
0.37	GO:0048200	Golgi transport vesicle coating

0.56	GO:0019905	syntaxin binding
0.38	GO:0032403	protein complex binding

0.61	GO:0070765	gamma-secretase complex
0.59	GO:0005789	endoplasmic reticulum membrane
0.58	GO:0042589	zymogen granule membrane
0.58	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.53	GO:0000139	Golgi membrane
0.44	GO:0042470	melanosome
0.43	GO:0030133	transport vesicle
0.42	GO:0030137	COPI-coated vesicle
0.42	GO:0030136	clathrin-coated vesicle
0.39	GO:0005801	cis-Golgi network

sp|P49756|RBM25_HUMAN
RNA-binding protein 25
Search

RBM25

0.91	RNA binding motif protein 25

0.67	GO:0006397	mRNA processing
0.60	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.54	GO:0042981	regulation of apoptotic process
0.37	GO:0008380	RNA splicing
0.36	GO:0042987	amyloid precursor protein catabolic process
0.35	GO:0006915	apoptotic process
0.35	GO:0016485	protein processing
0.33	GO:0035556	intracellular signal transduction

0.57	GO:0003723	RNA binding
0.36	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving
0.34	GO:0005515	protein binding

0.57	GO:0016607	nuclear speck
0.47	GO:0005681	spliceosomal complex
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.36

EC:3.4.23

GO:0042500

sp|P49757|NUMB_HUMAN
Protein numb homolog
Search

NUMB

0.96	NUMB, endocytic adaptor protein

0.87	GO:0021849	neuroblast division in subventricular zone
0.85	GO:0021670	lateral ventricle development
0.85	GO:1903077	negative regulation of protein localization to plasma membrane
0.82	GO:0034332	adherens junction organization
0.78	GO:0050769	positive regulation of neurogenesis
0.78	GO:0030335	positive regulation of cell migration
0.77	GO:0007409	axonogenesis
0.48	GO:0019221	cytokine-mediated signaling pathway
0.39	GO:0019538	protein metabolic process

0.85	GO:0045294	alpha-catenin binding
0.80	GO:0008013	beta-catenin binding
0.78	GO:0045296	cadherin binding

0.79	GO:0016323	basolateral plasma membrane
0.77	GO:0045177	apical part of cell
0.77	GO:0005769	early endosome
0.76	GO:0030136	clathrin-coated vesicle
0.74	GO:0019897	extrinsic component of plasma membrane
0.59	GO:0005634	nucleus

sp|P49758|RGS6_HUMAN
Regulator of G-protein signaling 6
Search

RGS6

0.94	Regulator of G-protein signaling 6

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.65	GO:0043547	positive regulation of GTPase activity
0.62	GO:0035556	intracellular signal transduction
0.36	GO:0009968	negative regulation of signal transduction
0.35	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway

0.66	GO:0005096	GTPase activator activity
0.63	GO:0004871	signal transducer activity
0.34	GO:0005515	protein binding

0.81	GO:1905360	GTPase complex
0.79	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.65	GO:0098797	plasma membrane protein complex
0.46	GO:0005829	cytosol
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|P49759|CLK1_HUMAN
Dual specificity protein kinase CLK1
Search

CLK1

0.95	CDC like kinase 1

0.76	GO:0043484	regulation of RNA splicing
0.74	GO:0046777	protein autophosphorylation
0.70	GO:0018108	peptidyl-tyrosine phosphorylation
0.65	GO:0018107	peptidyl-threonine phosphorylation
0.63	GO:0018105	peptidyl-serine phosphorylation

0.70	GO:0004713	protein tyrosine kinase activity
0.69	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.57

GO:0005634

nucleus

0.70

GO:0004713

sp|P49760|CLK2_HUMAN
Dual specificity protein kinase CLK2
Search

CLK2

0.64	Dual specificity protein kinase CLK2

0.63	GO:0006468	protein phosphorylation
0.53	GO:0032526	response to retinoic acid
0.53	GO:0010212	response to ionizing radiation
0.53	GO:0045721	negative regulation of gluconeogenesis
0.53	GO:0043484	regulation of RNA splicing
0.49	GO:0018212	peptidyl-tyrosine modification
0.38	GO:0015031	protein transport
0.36	GO:0006836	neurotransmitter transport
0.36	GO:0034125	negative regulation of MyD88-dependent toll-like receptor signaling pathway
0.36	GO:2000255	negative regulation of male germ cell proliferation

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0042802	identical protein binding
0.37	GO:0019905	syntaxin binding
0.34	GO:0031625	ubiquitin protein ligase binding

0.51	GO:0016604	nuclear body
0.35	GO:0012505	endomembrane system
0.34	GO:0070062	extracellular exosome
0.34	GO:0098588	bounding membrane of organelle
0.33	GO:0031984	organelle subcompartment
0.33	GO:0044444	cytoplasmic part
0.30	GO:0031224	intrinsic component of membrane

sp|P49761|CLK3_HUMAN
Dual specificity protein kinase CLK3
Search

CLK3

0.96	Dual specificity protein kinase CLK3

0.63	GO:0006468	protein phosphorylation
0.46	GO:0043484	regulation of RNA splicing
0.44	GO:0018212	peptidyl-tyrosine modification

0.64	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0004713	protein tyrosine kinase activity
0.43	GO:0042802	identical protein binding
0.43	GO:0004712	protein serine/threonine/tyrosine kinase activity
0.36	GO:0003723	RNA binding

0.47	GO:0045111	intermediate filament cytoskeleton
0.44	GO:0001669	acrosomal vesicle
0.44	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.64

GO:0004674

sp|P49763|PLGF_HUMAN
Placenta growth factor
Search

PGF

0.85	Placental growth factor b

0.76	GO:0010469	regulation of receptor activity
0.56	GO:0008284	positive regulation of cell proliferation
0.53	GO:0060754	positive regulation of mast cell chemotaxis
0.52	GO:0001658	branching involved in ureteric bud morphogenesis
0.52	GO:0060688	regulation of morphogenesis of a branching structure
0.52	GO:0050930	induction of positive chemotaxis
0.50	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.50	GO:0001936	regulation of endothelial cell proliferation
0.50	GO:0045766	positive regulation of angiogenesis
0.49	GO:0001666	response to hypoxia

0.78	GO:0008083	growth factor activity
0.52	GO:0005172	vascular endothelial growth factor receptor binding
0.41	GO:0042803	protein homodimerization activity
0.41	GO:0046982	protein heterodimerization activity
0.40	GO:0008201	heparin binding

0.49	GO:0005615	extracellular space
0.30	GO:0016020	membrane

sp|P49765|VEGFB_HUMAN
Vascular endothelial growth factor B
Search

VEGFB

0.87	vascular endothelial growth factor A precursor

0.76	GO:0010469	regulation of receptor activity
0.59	GO:0001944	vasculature development
0.57	GO:0060048	cardiac muscle contraction
0.55	GO:0050927	positive regulation of positive chemotaxis
0.54	GO:0060754	positive regulation of mast cell chemotaxis
0.54	GO:0006493	protein O-linked glycosylation
0.54	GO:0007507	heart development
0.54	GO:0001938	positive regulation of endothelial cell proliferation
0.54	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.53	GO:0045766	positive regulation of angiogenesis

0.78	GO:0008083	growth factor activity
0.69	GO:0008201	heparin binding
0.57	GO:0043183	vascular endothelial growth factor receptor 1 binding
0.56	GO:0043184	vascular endothelial growth factor receptor 2 binding
0.52	GO:0042803	protein homodimerization activity
0.52	GO:0046982	protein heterodimerization activity
0.46	GO:0042056	chemoattractant activity
0.41	GO:0001968	fibronectin binding
0.41	GO:0005161	platelet-derived growth factor receptor binding
0.40	GO:0005125	cytokine activity

0.51	GO:0005576	extracellular region
0.41	GO:0030141	secretory granule
0.39	GO:0009986	cell surface
0.38	GO:0060205	cytoplasmic vesicle lumen
0.30	GO:0016020	membrane

0.34

EC:5.2.1.8

GO:0003755

sp|P49767|VEGFC_HUMAN
Vascular endothelial growth factor C
Search

VEGFD

0.82	Vascular endothelial growth factor C

0.75	GO:0010469	regulation of receptor activity
0.63	GO:0060754	positive regulation of mast cell chemotaxis
0.62	GO:0050930	induction of positive chemotaxis
0.62	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.57	GO:0050918	positive chemotaxis
0.55	GO:0008284	positive regulation of cell proliferation
0.52	GO:0001525	angiogenesis
0.52	GO:0001936	regulation of endothelial cell proliferation
0.51	GO:0045766	positive regulation of angiogenesis
0.49	GO:0071542	dopaminergic neuron differentiation

0.78	GO:0008083	growth factor activity
0.64	GO:0005172	vascular endothelial growth factor receptor binding
0.58	GO:0042056	chemoattractant activity
0.45	GO:0005161	platelet-derived growth factor receptor binding
0.45	GO:0042803	protein homodimerization activity

0.51	GO:0005615	extracellular space
0.34	GO:0031093	platelet alpha granule lumen
0.30	GO:0016020	membrane

sp|P49768|PSN1_HUMAN
Presenilin-1
Search

PSEN1

0.80	Presenilin

0.81	GO:0007219	Notch signaling pathway
0.78	GO:0042987	amyloid precursor protein catabolic process
0.75	GO:0016485	protein processing
0.60	GO:0050435	amyloid-beta metabolic process
0.60	GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis
0.60	GO:1904797	negative regulation of core promoter binding
0.60	GO:0006509	membrane protein ectodomain proteolysis
0.59	GO:0021870	Cajal-Retzius cell differentiation
0.59	GO:1905908	positive regulation of amyloid fibril formation
0.59	GO:0002265	astrocyte activation involved in immune response

0.77	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving
0.55	GO:0008013	beta-catenin binding
0.55	GO:0030165	PDZ domain binding
0.54	GO:0045296	cadherin binding
0.52	GO:0005262	calcium channel activity
0.34	GO:0004867	serine-type endopeptidase inhibitor activity
0.33	GO:0003723	RNA binding

0.73	GO:0000139	Golgi membrane
0.71	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.71	GO:0098827	endoplasmic reticulum subcompartment
0.59	GO:0070765	gamma-secretase complex
0.58	GO:0005790	smooth endoplasmic reticulum
0.57	GO:0035253	ciliary rootlet
0.57	GO:0016235	aggresome
0.57	GO:0043198	dendritic shaft
0.55	GO:0030426	growth cone
0.54	GO:0098857	membrane microdomain

0.77

EC:3.4.23

GO:0042500

sp|P49770|EI2BB_HUMAN
Translation initiation factor eIF-2B subunit beta
Search

EIF2B2

0.88	Eukaryotic translation initiation factor 2B subunit beta

0.67	GO:0006413	translational initiation
0.62	GO:1904628	cellular response to phorbol 13-acetate 12-myristate
0.60	GO:0014003	oligodendrocyte development
0.59	GO:0001541	ovarian follicle development
0.58	GO:0042552	myelination
0.49	GO:0065009	regulation of molecular function
0.37	GO:0009749	response to glucose
0.37	GO:0043434	response to peptide hormone
0.36	GO:0009408	response to heat
0.35	GO:0045773	positive regulation of axon extension

0.68	GO:0003743	translation initiation factor activity
0.54	GO:0005085	guanyl-nucleotide exchange factor activity
0.49	GO:0032550	purine ribonucleoside binding
0.49	GO:0019001	guanyl nucleotide binding
0.43	GO:0032559	adenyl ribonucleotide binding
0.43	GO:0008144	drug binding
0.43	GO:0035639	purine ribonucleoside triphosphate binding

0.60	GO:0005851	eukaryotic translation initiation factor 2B complex
0.35	GO:0030424	axon
0.34	GO:0005829	cytosol

sp|P49771|FLT3L_HUMAN
Fms-related tyrosine kinase 3 ligand
Search

FLT3LG

0.97	Fms-related tyrosine kinase 3 ligand

0.76	GO:0010469	regulation of receptor activity
0.72	GO:0090290	positive regulation of osteoclast proliferation
0.71	GO:0071865	regulation of apoptotic process in bone marrow
0.71	GO:0030885	regulation of myeloid dendritic cell activation
0.70	GO:0071864	positive regulation of cell proliferation in bone marrow
0.70	GO:0032825	positive regulation of natural killer cell differentiation
0.69	GO:1901741	positive regulation of myoblast fusion
0.68	GO:0045663	positive regulation of myoblast differentiation
0.67	GO:0048873	homeostasis of number of cells within a tissue
0.66	GO:0035162	embryonic hemopoiesis

0.81	GO:0005125	cytokine activity
0.66	GO:0030971	receptor tyrosine kinase binding
0.59	GO:0042803	protein homodimerization activity
0.49	GO:0016301	kinase activity

0.68	GO:0031233	intrinsic component of external side of plasma membrane
0.58	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane

sp|P49773|HINT1_HUMAN
Histidine triad nucleotide-binding protein 1
Search

HINT1

0.54	Histidine triad nucleotide binding protein 1

0.49	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
0.48	GO:0009154	purine ribonucleotide catabolic process
0.45	GO:0050850	positive regulation of calcium-mediated signaling
0.39	GO:1903506	regulation of nucleic acid-templated transcription
0.39	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.39	GO:0010468	regulation of gene expression
0.36	GO:0016310	phosphorylation
0.36	GO:0006351	transcription, DNA-templated
0.34	GO:0019985	translesion synthesis
0.33	GO:0006260	DNA replication

0.37	GO:0016787	hydrolase activity
0.37	GO:0016301	kinase activity
0.35	GO:0005080	protein kinase C binding
0.35	GO:1901265	nucleoside phosphate binding
0.35	GO:0036094	small molecule binding
0.34	GO:0042803	protein homodimerization activity
0.33	GO:0003887	DNA-directed DNA polymerase activity
0.32	GO:0003677	DNA binding

0.47	GO:0000118	histone deacetylase complex
0.42	GO:0005829	cytosol
0.38	GO:0005886	plasma membrane
0.36	GO:0070062	extracellular exosome
0.34	GO:0016035	zeta DNA polymerase complex
0.34	GO:0005856	cytoskeleton
0.30	GO:0031224	intrinsic component of membrane

0.37

GO:0016787

sp|P49788|TIG1_HUMAN
Retinoic acid receptor responder protein 1
Search

RARRES1

0.97	Retinoic acid receptor responder protein 1

0.72	GO:0008285	negative regulation of cell proliferation
0.40	GO:0006468	protein phosphorylation

0.40	GO:0004672	protein kinase activity
0.37	GO:0030554	adenyl nucleotide binding
0.37	GO:0097367	carbohydrate derivative binding
0.37	GO:0008144	drug binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding

0.55	GO:0070062	extracellular exosome
0.30	GO:0044425	membrane part

sp|P49789|FHIT_HUMAN
Bis(5'-adenosyl)-triphosphatase
Search

FHIT

0.49	Fragile histidine triad gene

0.52	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
0.52	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
0.42	GO:0006163	purine nucleotide metabolic process
0.37	GO:0015962	diadenosine triphosphate metabolic process
0.36	GO:0015961	diadenosine polyphosphate catabolic process
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0010468	regulation of gene expression
0.35	GO:0009164	nucleoside catabolic process

0.53	GO:0047710	bis(5'-adenosyl)-triphosphatase activity
0.49	GO:0031625	ubiquitin protein ligase binding
0.47	GO:0042802	identical protein binding
0.35	GO:0043530	adenosine 5'-monophosphoramidase activity
0.34	GO:0016819	hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides
0.34	GO:1901265	nucleoside phosphate binding
0.34	GO:0016151	nickel cation binding
0.34	GO:0036094	small molecule binding
0.33	GO:0017111	nucleoside-triphosphatase activity
0.33	GO:0016746	transferase activity, transferring acyl groups

0.51	GO:0001650	fibrillar center
0.45	GO:0005829	cytosol
0.40	GO:0005886	plasma membrane
0.39	GO:0005856	cytoskeleton
0.37	GO:0070062	extracellular exosome
0.33	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.53	EC:3.6.1.29	GO:0047710
0.53	KEGG:R00187	GO:0047710

sp|P49790|NU153_HUMAN
Nuclear pore complex protein Nup153
Search

NUP153

0.73	Nuclear pore complex protein Nup153

0.42	GO:0046832	negative regulation of RNA export from nucleus
0.41	GO:0051292	nuclear pore complex assembly
0.38	GO:0006913	nucleocytoplasmic transport
0.38	GO:0051028	mRNA transport
0.36	GO:0015031	protein transport
0.34	GO:0034504	protein localization to nucleus
0.34	GO:0007077	mitotic nuclear envelope disassembly
0.34	GO:0072594	establishment of protein localization to organelle
0.34	GO:1900034	regulation of cellular response to heat
0.33	GO:0006110	regulation of glycolytic process

0.80	GO:0017056	structural constituent of nuclear pore
0.52	GO:0046872	metal ion binding
0.41	GO:0043495	protein membrane anchor
0.38	GO:0042802	identical protein binding
0.35	GO:0008139	nuclear localization sequence binding
0.34	GO:0003677	DNA binding
0.33	GO:0008536	Ran GTPase binding
0.33	GO:0003682	chromatin binding
0.33	GO:0015288	porin activity
0.32	GO:0003899	DNA-directed 5'-3' RNA polymerase activity

0.42	GO:0031965	nuclear membrane
0.41	GO:0005643	nuclear pore
0.41	GO:0042405	nuclear inclusion body
0.39	GO:0034399	nuclear periphery
0.38	GO:0005730	nucleolus
0.37	GO:0005829	cytosol
0.34	GO:0005642	annulate lamellae
0.33	GO:0046930	pore complex
0.33	GO:0005654	nucleoplasm
0.32	GO:0044216	other organism cell

0.32

GO:0003899

sp|P49792|RBP2_HUMAN
E3 SUMO-protein ligase RanBP2
Search

0.10	E3 SUMO-protein ligase RanBP2

0.69	GO:0000413	protein peptidyl-prolyl isomerization
0.67	GO:0046907	intracellular transport
0.59	GO:0006457	protein folding
0.50	GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis
0.50	GO:0033133	positive regulation of glucokinase activity
0.49	GO:0046604	positive regulation of mitotic centrosome separation
0.49	GO:0006606	protein import into nucleus
0.48	GO:0051642	centrosome localization
0.47	GO:0000082	G1/S transition of mitotic cell cycle
0.46	GO:0016925	protein sumoylation

0.69	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.52	GO:0046872	metal ion binding
0.49	GO:0016874	ligase activity
0.48	GO:0008536	Ran GTPase binding
0.44	GO:0005096	GTPase activator activity
0.39	GO:0004930	G-protein coupled receptor activity
0.36	GO:0019789	SUMO transferase activity
0.35	GO:0032403	protein complex binding
0.33	GO:0003723	RNA binding

0.50	GO:0005642	annulate lamellae
0.49	GO:0042405	nuclear inclusion body
0.49	GO:0044614	nuclear pore cytoplasmic filaments
0.49	GO:0044615	nuclear pore nuclear basket
0.46	GO:0031965	nuclear membrane
0.45	GO:0005813	centrosome
0.40	GO:0005739	mitochondrion
0.37	GO:1990723	cytoplasmic periphery of the nuclear pore complex
0.30	GO:0044216	other organism cell
0.30	GO:0016021	integral component of membrane

0.69

EC:5.2.1.8

GO:0003755

sp|P49795|RGS19_HUMAN
Regulator of G-protein signaling 19
Search

RGS19

0.97	Regulator of G-protein signaling protein GAIP

0.70	GO:0043547	positive regulation of GTPase activity
0.53	GO:0009968	negative regulation of signal transduction
0.46	GO:0006914	autophagy
0.42	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.41	GO:0007264	small GTPase mediated signal transduction
0.40	GO:0007186	G-protein coupled receptor signaling pathway

0.70	GO:0005096	GTPase activator activity
0.53	GO:0001965	G-protein alpha-subunit binding

0.68	GO:0031410	cytoplasmic vesicle
0.56	GO:0005802	trans-Golgi network
0.52	GO:0005886	plasma membrane
0.52	GO:0005903	brush border
0.50	GO:0045121	membrane raft
0.42	GO:1905360	GTPase complex
0.41	GO:0098562	cytoplasmic side of membrane
0.41	GO:0019898	extrinsic component of membrane
0.40	GO:0000139	Golgi membrane
0.38	GO:0005634	nucleus

sp|P49796|RGS3_HUMAN
Regulator of G-protein signaling 3
Search

RGS3

0.73	Regulator of G protein signaling 3

0.55	GO:0043547	positive regulation of GTPase activity
0.49	GO:0007340	acrosome reaction
0.42	GO:0009968	negative regulation of signal transduction
0.41	GO:0023052	signaling
0.41	GO:0007154	cell communication
0.40	GO:0018105	peptidyl-serine phosphorylation
0.39	GO:0051716	cellular response to stimulus
0.38	GO:0048488	synaptic vesicle endocytosis
0.38	GO:0017158	regulation of calcium ion-dependent exocytosis
0.38	GO:0017156	calcium ion regulated exocytosis

0.55	GO:0005096	GTPase activator activity
0.38	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.38	GO:0019905	syntaxin binding
0.38	GO:0004674	protein serine/threonine kinase activity
0.37	GO:0005544	calcium-dependent phospholipid binding
0.37	GO:0030276	clathrin binding
0.36	GO:0005509	calcium ion binding

0.64	GO:0005654	nucleoplasm
0.63	GO:0005829	cytosol
0.44	GO:0005886	plasma membrane
0.38	GO:0030672	synaptic vesicle membrane
0.30	GO:0016021	integral component of membrane

0.38

GO:0004674

sp|P49798|RGS4_HUMAN
Regulator of G-protein signaling 4
Search

RGS4

0.97	LOW QUALITY PROTEIN: regulator of G-protein signaling 4

0.72	GO:0043547	positive regulation of GTPase activity
0.66	GO:0007186	G-protein coupled receptor signaling pathway
0.47	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.43	GO:0009968	negative regulation of signal transduction
0.41	GO:0031018	endocrine pancreas development
0.40	GO:0007626	locomotory behavior
0.40	GO:0007409	axonogenesis
0.36	GO:0071901	negative regulation of protein serine/threonine kinase activity
0.35	GO:0043405	regulation of MAP kinase activity
0.34	GO:0010519	negative regulation of phospholipase activity

0.73	GO:0005096	GTPase activator activity
0.40	GO:0001965	G-protein alpha-subunit binding
0.35	GO:0005516	calmodulin binding

0.45	GO:0005634	nucleus
0.40	GO:0005737	cytoplasm
0.39	GO:0005886	plasma membrane
0.35	GO:0043234	protein complex
0.34	GO:0098562	cytoplasmic side of membrane
0.33	GO:0019898	extrinsic component of membrane
0.32	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part

sp|P49802|RGS7_HUMAN
Regulator of G-protein signaling 7
Search

RGS7

0.93	Regulator of G-protein signalling 7

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.59	GO:0035556	intracellular signal transduction
0.50	GO:0043547	positive regulation of GTPase activity
0.37	GO:0009968	negative regulation of signal transduction
0.36	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.34	GO:0006457	protein folding

0.63	GO:0004871	signal transducer activity
0.55	GO:0031681	G-protein beta-subunit binding
0.50	GO:0005096	GTPase activator activity

0.80	GO:1905360	GTPase complex
0.79	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.65	GO:0098797	plasma membrane protein complex
0.46	GO:0005829	cytosol
0.37	GO:0044292	dendrite terminus
0.34	GO:0005634	nucleus

sp|P49810|PSN2_HUMAN
Presenilin-2
Search

PSEN2

0.80	Presenilin

0.81	GO:0007219	Notch signaling pathway
0.80	GO:0042987	amyloid precursor protein catabolic process
0.75	GO:0016485	protein processing
0.58	GO:0006509	membrane protein ectodomain proteolysis
0.56	GO:0035556	intracellular signal transduction
0.53	GO:0050435	amyloid-beta metabolic process
0.50	GO:0043085	positive regulation of catalytic activity
0.49	GO:0007220	Notch receptor processing
0.46	GO:0043066	negative regulation of apoptotic process
0.45	GO:0006816	calcium ion transport

0.76	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving
0.34	GO:0005515	protein binding
0.33	GO:0008324	cation transmembrane transporter activity

0.73	GO:0000139	Golgi membrane
0.71	GO:0005789	endoplasmic reticulum membrane
0.54	GO:0005637	nuclear inner membrane
0.52	GO:0000776	kinetochore
0.52	GO:0005813	centrosome
0.49	GO:0035253	ciliary rootlet
0.49	GO:0043198	dendritic shaft
0.48	GO:0005887	integral component of plasma membrane
0.48	GO:0031594	neuromuscular junction
0.48	GO:0030426	growth cone

0.76

EC:3.4.23

GO:0042500

sp|P49815|TSC2_HUMAN
Tuberin
Search

TSC2

0.90	LOW QUALITY PROTEIN: tuberin

0.84	GO:0032007	negative regulation of TOR signaling
0.76	GO:0043547	positive regulation of GTPase activity
0.74	GO:0051056	regulation of small GTPase mediated signal transduction
0.59	GO:0043276	anoikis
0.56	GO:0016239	positive regulation of macroautophagy
0.49	GO:0046627	negative regulation of insulin receptor signaling pathway
0.49	GO:0051898	negative regulation of protein kinase B signaling
0.47	GO:0030178	negative regulation of Wnt signaling pathway
0.44	GO:0051726	regulation of cell cycle
0.42	GO:0035295	tube development

0.76	GO:0005096	GTPase activator activity
0.55	GO:0019902	phosphatase binding
0.52	GO:0031267	small GTPase binding
0.52	GO:0042803	protein homodimerization activity
0.39	GO:0071889	14-3-3 protein binding
0.36	GO:0047485	protein N-terminus binding
0.35	GO:0046982	protein heterodimerization activity

0.85	GO:0033596	TSC1-TSC2 complex
0.61	GO:0005634	nucleus
0.54	GO:0048471	perinuclear region of cytoplasm
0.53	GO:0005764	lysosome
0.49	GO:0005794	Golgi apparatus
0.36	GO:0030426	growth cone
0.36	GO:0005901	caveola
0.35	GO:0043025	neuronal cell body
0.35	GO:0030425	dendrite
0.34	GO:0005856	cytoskeleton

sp|P49821|NDUV1_HUMAN
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Search

NDUFV1

0.72	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

0.52	GO:0055114	oxidation-reduction process
0.44	GO:0006119	oxidative phosphorylation
0.35	GO:0032981	mitochondrial respiratory chain complex I assembly

0.69	GO:0010181	FMN binding
0.67	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.65	GO:0051539	4 iron, 4 sulfur cluster binding
0.65	GO:0051287	NAD binding
0.52	GO:0046872	metal ion binding
0.36	GO:0004364	glutathione transferase activity
0.33	GO:0005515	protein binding

0.60	GO:0070469	respiratory chain
0.59	GO:0031966	mitochondrial membrane
0.59	GO:0019866	organelle inner membrane
0.51	GO:0030964	NADH dehydrogenase complex
0.49	GO:0098798	mitochondrial protein complex
0.47	GO:0005829	cytosol
0.47	GO:1990204	oxidoreductase complex
0.44	GO:0098796	membrane protein complex
0.30	GO:0016021	integral component of membrane

0.67

EC:1.6.5.3

GO:0008137

sp|P49840|GSK3A_HUMAN
Glycogen synthase kinase-3 alpha
Search

0.83	LOW QUALITY PROTEIN: glycogen synthase kinase-3 alpha

0.63	GO:0006468	protein phosphorylation
0.52	GO:0010822	positive regulation of mitochondrion organization
0.51	GO:0048513	animal organ development
0.51	GO:0018209	peptidyl-serine modification
0.50	GO:1904779	regulation of protein localization to centrosome
0.50	GO:0051534	negative regulation of NFAT protein import into nucleus
0.50	GO:0006983	ER overload response
0.50	GO:0010942	positive regulation of cell death
0.50	GO:0051050	positive regulation of transport
0.49	GO:0048468	cell development

0.69	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0050321	tau-protein kinase activity
0.50	GO:0034452	dynactin binding
0.49	GO:0034236	protein kinase A catalytic subunit binding
0.49	GO:0051059	NF-kappaB binding
0.48	GO:0002039	p53 binding

0.49	GO:0030877	beta-catenin destruction complex
0.46	GO:0005813	centrosome
0.42	GO:0005634	nucleus
0.40	GO:1990909	Wnt signalosome
0.39	GO:0043198	dendritic shaft
0.39	GO:0005739	mitochondrion
0.39	GO:0005886	plasma membrane
0.39	GO:0030426	growth cone
0.38	GO:0014069	postsynaptic density
0.38	GO:0043025	neuronal cell body

0.69

GO:0004674

sp|P49841|GSK3B_HUMAN
Glycogen synthase kinase-3 beta
Search

GSK3B

0.80	Glycogen synthase kinase-3 beta

0.63	GO:0006468	protein phosphorylation
0.58	GO:0071109	superior temporal gyrus development
0.57	GO:0051534	negative regulation of NFAT protein import into nucleus
0.56	GO:1904779	regulation of protein localization to centrosome
0.56	GO:0006983	ER overload response
0.54	GO:0001954	positive regulation of cell-matrix adhesion
0.54	GO:0046827	positive regulation of protein export from nucleus
0.54	GO:1901216	positive regulation of neuron death
0.54	GO:0001837	epithelial to mesenchymal transition
0.54	GO:0021766	hippocampus development

0.69	GO:0004674	protein serine/threonine kinase activity
0.57	GO:0050321	tau-protein kinase activity
0.56	GO:0034452	dynactin binding
0.55	GO:0051059	NF-kappaB binding
0.55	GO:0034236	protein kinase A catalytic subunit binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.53	GO:0002039	p53 binding

0.55	GO:0030877	beta-catenin destruction complex
0.50	GO:0005813	centrosome
0.44	GO:0005634	nucleus
0.41	GO:0005886	plasma membrane
0.41	GO:1990909	Wnt signalosome
0.39	GO:0043198	dendritic shaft
0.39	GO:0030426	growth cone
0.38	GO:0014069	postsynaptic density
0.38	GO:0043025	neuronal cell body
0.38	GO:0048471	perinuclear region of cytoplasm

0.69

GO:0004674

sp|P49842|STK19_HUMAN
Serine/threonine-protein kinase 19
Search

STK19

0.96	Serine/threonine-protein kinase 19

0.52	GO:0016310	phosphorylation
0.37	GO:0006464	cellular protein modification process

0.54	GO:0016301	kinase activity
0.37	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.36	GO:0140096	catalytic activity, acting on a protein
0.36	GO:0030554	adenyl nucleotide binding
0.36	GO:0097367	carbohydrate derivative binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005515	protein binding

0.63

GO:0016607

nuclear speck

0.37

GO:0016773

sp|P49848|TAF6_HUMAN
Transcription initiation factor TFIID subunit 6
Search

TAF6

0.88	Transcription initiation factor TFIID subunit 6

0.80	GO:0051090	regulation of DNA binding transcription factor activity
0.68	GO:0006352	DNA-templated transcription, initiation
0.53	GO:0006413	translational initiation
0.51	GO:0045786	negative regulation of cell cycle
0.51	GO:0006366	transcription by RNA polymerase II
0.38	GO:0008285	negative regulation of cell proliferation
0.36	GO:0009301	snRNA transcription
0.36	GO:1901796	regulation of signal transduction by p53 class mediator
0.35	GO:0006354	DNA-templated transcription, elongation
0.34	GO:0007221	positive regulation of transcription of Notch receptor target

0.73	GO:0046982	protein heterodimerization activity
0.58	GO:0017162	aryl hydrocarbon receptor binding
0.54	GO:0003743	translation initiation factor activity
0.44	GO:0003700	DNA binding transcription factor activity
0.42	GO:0003677	DNA binding
0.33	GO:0016758	transferase activity, transferring hexosyl groups

0.82	GO:0046695	SLIK (SAGA-like) complex
0.80	GO:0000124	SAGA complex
0.80	GO:0005669	transcription factor TFIID complex
0.56	GO:0033276	transcription factor TFTC complex
0.54	GO:0071339	MLL1 complex
0.48	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.33

GO:0016758

sp|P49862|KLK7_HUMAN
Kallikrein-7
Search

0.89	Glandular kallikrein-7, submandibular/renal

0.61	GO:0006508	proteolysis
0.51	GO:0002803	positive regulation of antibacterial peptide production
0.45	GO:0051604	protein maturation
0.40	GO:0009611	response to wounding
0.40	GO:0032501	multicellular organismal process
0.40	GO:0008544	epidermis development
0.40	GO:0031642	negative regulation of myelination
0.40	GO:0043616	keratinocyte proliferation
0.39	GO:1903035	negative regulation of response to wounding
0.39	GO:0050807	regulation of synapse organization

0.69	GO:0004252	serine-type endopeptidase activity
0.36	GO:0005509	calcium ion binding
0.34	GO:0008237	metallopeptidase activity
0.34	GO:0005515	protein binding
0.33	GO:0008201	heparin binding
0.32	GO:0005044	scavenger receptor activity
0.32	GO:0008061	chitin binding
0.32	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.32	GO:0004180	carboxypeptidase activity
0.32	GO:0008270	zinc ion binding

0.53	GO:0030141	secretory granule
0.51	GO:0005615	extracellular space
0.40	GO:0097180	serine protease inhibitor complex
0.36	GO:1903561	extracellular vesicle
0.34	GO:0046658	anchored component of plasma membrane
0.34	GO:0097223	sperm part
0.33	GO:0010494	cytoplasmic stress granule
0.33	GO:0031012	extracellular matrix
0.32	GO:0009986	cell surface
0.32	GO:0019897	extrinsic component of plasma membrane

0.69

GO:0004252

sp|P49863|GRAK_HUMAN
Granzyme K
Search

GZMK

0.86	Complement factor D

0.61	GO:0006508	proteolysis
0.38	GO:0006957	complement activation, alternative pathway
0.38	GO:0009405	pathogenesis
0.37	GO:0032078	negative regulation of endodeoxyribonuclease activity
0.37	GO:0051354	negative regulation of oxidoreductase activity
0.37	GO:0065008	regulation of biological quality
0.36	GO:0043392	negative regulation of DNA binding
0.36	GO:0043065	positive regulation of apoptotic process
0.36	GO:0032501	multicellular organismal process
0.35	GO:0030163	protein catabolic process

0.69	GO:0004252	serine-type endopeptidase activity
0.38	GO:0090729	toxin activity
0.36	GO:0015035	protein disulfide oxidoreductase activity
0.36	GO:0005044	scavenger receptor activity
0.35	GO:0042803	protein homodimerization activity
0.35	GO:0009055	electron transfer activity
0.34	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
0.34	GO:0005057	signal transducer activity, downstream of receptor
0.34	GO:0005509	calcium ion binding
0.33	GO:0008201	heparin binding

0.40	GO:0005576	extracellular region
0.36	GO:0030141	secretory granule
0.34	GO:0005634	nucleus
0.34	GO:0005766	primary lysosome
0.34	GO:0060205	cytoplasmic vesicle lumen
0.34	GO:0005775	vacuolar lumen
0.33	GO:0043234	protein complex
0.33	GO:0097223	sperm part
0.33	GO:0045177	apical part of cell
0.33	GO:0009986	cell surface

0.69

GO:0004252

sp|P49888|ST1E1_HUMAN
Estrogen sulfotransferase
Search

SULT1E1

0.55	Estrogen sulfotransferase

0.62	GO:0051923	sulfation
0.62	GO:0042403	thyroid hormone metabolic process
0.56	GO:0006805	xenobiotic metabolic process
0.52	GO:0006068	ethanol catabolic process
0.52	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
0.47	GO:0009812	flavonoid metabolic process
0.45	GO:0008210	estrogen metabolic process
0.44	GO:0030855	epithelial cell differentiation
0.41	GO:0006706	steroid catabolic process
0.41	GO:0045600	positive regulation of fat cell differentiation

0.78	GO:0008146	sulfotransferase activity
0.43	GO:0005496	steroid binding
0.35	GO:0005515	protein binding

0.38	GO:0031965	nuclear membrane
0.38	GO:0005829	cytosol

0.78

GO:0008146

sp|P49895|IOD1_HUMAN
Type I iodothyronine deiodinase
Search

DIO1

0.76	Type I iodothyronine deiodinase

0.78	GO:0042446	hormone biosynthetic process
0.52	GO:0055114	oxidation-reduction process
0.37	GO:0006590	thyroid hormone generation
0.37	GO:0061074	regulation of neural retina development
0.35	GO:0045454	cell redox homeostasis
0.34	GO:0006091	generation of precursor metabolites and energy

0.85	GO:0004800	thyroxine 5'-deiodinase activity
0.41	GO:0008430	selenium binding

0.45	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.85

EC:1.97.1.10

GO:0004800

sp|P49901|MCSP_HUMAN
Sperm mitochondrial-associated cysteine-rich protein
Search

SMCP

0.97	Sperm mitochondria associated cysteine rich protein (Fragment)

0.87	GO:0007341	penetration of zona pellucida
0.85	GO:0030317	flagellated sperm motility
0.63	GO:0007339	binding of sperm to zona pellucida

0.57

GO:0005515

protein binding

0.61	GO:0005739	mitochondrion
0.59	GO:0031967	organelle envelope
0.58	GO:0031090	organelle membrane
0.46	GO:0098805	whole membrane
0.44	GO:0019867	outer membrane

sp|P49902|5NTC_HUMAN
Cytosolic purine 5'-nucleotidase
Search

NT5C2

0.51	Cytosolic purine 5'-nucleotidase

0.49	GO:0046085	adenosine metabolic process
0.44	GO:0016311	dephosphorylation
0.44	GO:0046040	IMP metabolic process
0.34	GO:0006195	purine nucleotide catabolic process
0.32	GO:0016310	phosphorylation

0.53	GO:0046872	metal ion binding
0.47	GO:0008253	5'-nucleotidase activity
0.36	GO:0050146	nucleoside phosphotransferase activity
0.35	GO:1901265	nucleoside phosphate binding
0.34	GO:0036094	small molecule binding
0.34	GO:0005515	protein binding

0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.47

EC:3.1.3.5

GO:0008253

sp|P49903|SPS1_HUMAN
Selenide, water dikinase 1
Search

SEPHS1

0.96	Selenide, water dikinase 1

0.78	GO:0016260	selenocysteine biosynthetic process
0.57	GO:0016310	phosphorylation
0.36	GO:0001887	selenium compound metabolic process
0.34	GO:0036211	protein modification process
0.33	GO:0044267	cellular protein metabolic process

0.81	GO:0004756	selenide, water dikinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0042802	identical protein binding
0.44	GO:0046982	protein heterodimerization activity
0.34	GO:0032550	purine ribonucleoside binding
0.34	GO:0019001	guanyl nucleotide binding

0.45	GO:0031965	nuclear membrane
0.38	GO:0005886	plasma membrane
0.34	GO:0005829	cytosol

0.81	EC:2.7.9.3	GO:0004756
0.81	KEGG:R03595	GO:0004756

sp|P49908|SEPP1_HUMAN
Selenoprotein P
Search

0.88	LOW QUALITY PROTEIN: selenoprotein P

0.48	GO:0001887	selenium compound metabolic process
0.48	GO:0007626	locomotory behavior
0.47	GO:0007420	brain development
0.46	GO:0009791	post-embryonic development
0.46	GO:0040007	growth
0.46	GO:0019953	sexual reproduction
0.43	GO:0002576	platelet degranulation
0.41	GO:0010269	response to selenium ion
0.39	GO:0006979	response to oxidative stress

0.85	GO:0008430	selenium binding
0.36	GO:0005515	protein binding

0.46	GO:0005576	extracellular region
0.44	GO:0031089	platelet dense granule lumen
0.30	GO:0016020	membrane

sp|P49910|ZN165_HUMAN
Zinc finger protein 165
Search

0.93	zinc finger protein with KRAB and SCAN domains 4

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.54	GO:0006351	transcription, DNA-templated
0.40	GO:0015074	DNA integration
0.40	GO:2000773	negative regulation of cellular senescence
0.39	GO:0007040	lysosome organization
0.38	GO:0051254	positive regulation of RNA metabolic process
0.37	GO:0051253	negative regulation of RNA metabolic process
0.37	GO:0010557	positive regulation of macromolecule biosynthetic process

0.61	GO:0003700	DNA binding transcription factor activity
0.51	GO:0046872	metal ion binding
0.50	GO:0003676	nucleic acid binding
0.39	GO:0005515	protein binding
0.38	GO:0003682	chromatin binding

0.61	GO:0005634	nucleus
0.41	GO:0031974	membrane-enclosed lumen
0.40	GO:0005829	cytosol
0.38	GO:0044446	intracellular organelle part
0.33	GO:0070062	extracellular exosome

sp|P49913|CAMP_HUMAN
Cathelicidin antimicrobial peptide
Search

CAMP

0.95	Preprocathelicidin antimicrobial peptide

0.72	GO:0006952	defense response
0.63	GO:0009617	response to bacterium
0.53	GO:0044140	negative regulation of growth of symbiont on or near host surface
0.51	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
0.50	GO:0044130	negative regulation of growth of symbiont in host
0.50	GO:0051851	modification by host of symbiont morphology or physiology
0.48	GO:0031640	killing of cells of other organism
0.47	GO:0051818	disruption of cells of other organism involved in symbiotic interaction
0.39	GO:0071354	cellular response to interleukin-6
0.39	GO:0002385	mucosal immune response

0.34	GO:0005515	protein binding
0.32	GO:0046872	metal ion binding
0.32	GO:0003676	nucleic acid binding

0.66	GO:0005576	extracellular region
0.50	GO:0042581	specific granule
0.37	GO:1904724	tertiary granule lumen
0.36	GO:0034774	secretory granule lumen
0.36	GO:0042995	cell projection
0.30	GO:0031224	intrinsic component of membrane

sp|P49914|MTHFS_HUMAN
5-formyltetrahydrofolate cyclo-ligase
Search

MTHFS

0.42	5-formyltetrahydrofolate cyclo-ligase

0.47	GO:0035999	tetrahydrofolate interconversion
0.44	GO:0009396	folic acid-containing compound biosynthetic process
0.44	GO:0046657	folic acid catabolic process
0.39	GO:0006536	glutamate metabolic process
0.37	GO:0043066	negative regulation of apoptotic process
0.34	GO:0015942	formate metabolic process
0.34	GO:0001836	release of cytochrome c from mitochondria
0.34	GO:0038034	signal transduction in absence of ligand
0.33	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
0.33	GO:0097191	extrinsic apoptotic signaling pathway

0.78	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0046872	metal ion binding
0.41	GO:0072341	modified amino acid binding
0.41	GO:0031406	carboxylic acid binding
0.40	GO:0033218	amide binding
0.39	GO:0019842	vitamin binding
0.33	GO:0042803	protein homodimerization activity

0.42	GO:0005739	mitochondrion
0.39	GO:0031974	membrane-enclosed lumen
0.39	GO:0005829	cytosol
0.37	GO:0044446	intracellular organelle part
0.33	GO:0098805	whole membrane
0.33	GO:0098588	bounding membrane of organelle
0.32	GO:0019867	outer membrane
0.32	GO:0031975	envelope
0.30	GO:0016021	integral component of membrane

0.78	EC:6.3.3.2	GO:0030272
0.78	KEGG:R02301	GO:0030272

sp|P49915|GUAA_HUMAN
GMP synthase [glutamine-hydrolyzing]
Search

GMPS

0.44	Glutamine-hydrolyzing GMP synthase

0.77	GO:0006177	GMP biosynthetic process
0.37	GO:0006541	glutamine metabolic process
0.36	GO:1901367	response to L-cysteine
0.34	GO:0009113	purine nucleobase biosynthetic process
0.34	GO:0042493	response to drug
0.33	GO:0007186	G-protein coupled receptor signaling pathway

0.79	GO:0003922	GMP synthase (glutamine-hydrolyzing) activity
0.58	GO:0016462	pyrophosphatase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0003921	GMP synthase activity
0.34	GO:0019899	enzyme binding
0.34	GO:0004930	G-protein coupled receptor activity

0.48	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:6.3.5.2

GO:0003922

sp|P49916|DNLI3_HUMAN
DNA ligase 3
Search

LIG3

0.47	DNA ligase

0.80	GO:0051103	DNA ligation involved in DNA repair
0.66	GO:0071897	DNA biosynthetic process
0.65	GO:0006260	DNA replication
0.65	GO:0006310	DNA recombination
0.61	GO:0090298	negative regulation of mitochondrial DNA replication
0.54	GO:0006302	double-strand break repair
0.51	GO:0006284	base-excision repair
0.47	GO:0022616	DNA strand elongation
0.44	GO:0000726	non-recombinational repair
0.40	GO:0043504	mitochondrial DNA repair

0.78	GO:0003910	DNA ligase (ATP) activity
0.62	GO:0008270	zinc ion binding
0.55	GO:0003677	DNA binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding

0.50	GO:0005654	nucleoplasm
0.42	GO:0070421	DNA ligase III-XRCC1 complex
0.41	GO:0005739	mitochondrion
0.38	GO:0000795	synaptonemal complex

0.78

EC:6.5.1.1

GO:0003910

sp|P49917|DNLI4_HUMAN
DNA ligase 4
Search

LIG4

0.47	DNA ligase

0.80	GO:0051103	DNA ligation involved in DNA repair
0.67	GO:0071897	DNA biosynthetic process
0.66	GO:0006260	DNA replication
0.65	GO:0006310	DNA recombination
0.63	GO:0097680	double-strand break repair via classical nonhomologous end joining
0.62	GO:0006297	nucleotide-excision repair, DNA gap filling
0.62	GO:0002328	pro-B cell differentiation
0.61	GO:0016445	somatic diversification of immunoglobulins
0.60	GO:0002568	somatic diversification of T cell receptor genes
0.60	GO:0000012	single strand break repair

0.78	GO:0003910	DNA ligase (ATP) activity
0.57	GO:0008022	protein C-terminus binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.55	GO:0003677	DNA binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0046872	metal ion binding

0.64	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex
0.63	GO:0032807	DNA ligase IV complex
0.56	GO:0036464	cytoplasmic ribonucleoprotein granule
0.54	GO:0000793	condensed chromosome
0.51	GO:0005654	nucleoplasm
0.35	GO:0000784	nuclear chromosome, telomeric region

0.78

EC:6.5.1.1

GO:0003910

sp|P49918|CDN1C_HUMAN
Cyclin-dependent kinase inhibitor 1C
Search

CDKN1C

0.88	Dual specificity phosphatase 8

0.73	GO:0007050	cell cycle arrest
0.72	GO:0071901	negative regulation of protein serine/threonine kinase activity
0.64	GO:0007346	regulation of mitotic cell cycle
0.52	GO:1904030	negative regulation of cyclin-dependent protein kinase activity
0.52	GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus
0.51	GO:0042127	regulation of cell proliferation
0.51	GO:1902746	regulation of lens fiber cell differentiation
0.50	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
0.50	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
0.48	GO:0010629	negative regulation of gene expression

0.75	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
0.47	GO:0016301	kinase activity
0.44	GO:0032403	protein complex binding
0.44	GO:0008995	ribonuclease E activity
0.41	GO:0004521	endoribonuclease activity
0.39	GO:0008270	zinc ion binding
0.39	GO:0000287	magnesium ion binding
0.39	GO:0016746	transferase activity, transferring acyl groups
0.38	GO:0003723	RNA binding
0.35	GO:0019903	protein phosphatase binding

0.55	GO:0005634	nucleus
0.42	GO:0009898	cytoplasmic side of plasma membrane
0.41	GO:0005737	cytoplasm
0.37	GO:1902494	catalytic complex
0.35	GO:0019867	outer membrane
0.35	GO:0044462	external encapsulating structure part
0.34	GO:0030313	cell envelope
0.34	GO:0032153	cell division site
0.34	GO:0043234	protein complex
0.32	GO:0005887	integral component of plasma membrane

0.39	EC:2.3	GO:0016746
0.35	KEGG:R03028	GO:0018801

sp|P49959|MRE11_HUMAN
Double-strand break repair protein MRE11
Search

MRE11

0.89	Double-strand break repair protein MRE11

0.74	GO:0051321	meiotic cell cycle
0.73	GO:0006302	double-strand break repair
0.62	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.61	GO:0031860	telomeric 3' overhang formation
0.60	GO:0032876	negative regulation of DNA endoreduplication
0.59	GO:0031954	positive regulation of protein autophosphorylation
0.59	GO:0031573	intra-S DNA damage checkpoint
0.58	GO:0032206	positive regulation of telomere maintenance
0.57	GO:0007095	mitotic G2 DNA damage checkpoint
0.55	GO:0000726	non-recombinational repair

0.70	GO:0030145	manganese ion binding
0.69	GO:0008408	3'-5' exonuclease activity
0.64	GO:0004519	endonuclease activity
0.57	GO:0008022	protein C-terminus binding
0.56	GO:0045296	cadherin binding
0.52	GO:0042802	identical protein binding
0.51	GO:0004003	ATP-dependent DNA helicase activity
0.50	GO:0004536	deoxyribonuclease activity
0.42	GO:0003677	DNA binding
0.33	GO:0004930	G-protein coupled receptor activity

0.81	GO:0030870	Mre11 complex
0.58	GO:0016605	PML body
0.57	GO:0035861	site of double-strand break
0.56	GO:0000784	nuclear chromosome, telomeric region
0.40	GO:0005737	cytoplasm
0.35	GO:0000794	condensed nuclear chromosome
0.34	GO:0000790	nuclear chromatin
0.30	GO:0016020	membrane

sp|P49961|ENTP1_HUMAN
Ectonucleoside triphosphate diphosphohydrolase 1
Search

ENTPD1

0.95	Ectonucleoside triphosphate diphosphohydrolase 1

0.40	GO:0071405	cellular response to methanol
0.39	GO:0045471	response to ethanol
0.38	GO:0010038	response to metal ion
0.38	GO:0007596	blood coagulation
0.38	GO:0009137	purine nucleoside diphosphate catabolic process
0.38	GO:0009191	ribonucleoside diphosphate catabolic process
0.37	GO:0034656	nucleobase-containing small molecule catabolic process
0.36	GO:0010238	response to proline
0.36	GO:0001775	cell activation
0.36	GO:0033602	negative regulation of dopamine secretion

0.51	GO:0016787	hydrolase activity
0.36	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005515	protein binding

0.37	GO:0005605	basal lamina
0.37	GO:0070062	extracellular exosome
0.35	GO:0014069	postsynaptic density
0.35	GO:0016323	basolateral plasma membrane
0.35	GO:0008021	synaptic vesicle
0.35	GO:0043025	neuronal cell body
0.34	GO:0097060	synaptic membrane
0.34	GO:0043005	neuron projection
0.34	GO:0009986	cell surface
0.34	GO:0005887	integral component of plasma membrane

0.51

GO:0016787

sp|P50052|AGTR2_HUMAN
Type-2 angiotensin II receptor
Search

AGTR2

0.97	Angiotensin II receptor type 2

0.78	GO:0038166	angiotensin-activated signaling pathway
0.74	GO:0097746	regulation of blood vessel diameter
0.71	GO:0006954	inflammatory response
0.67	GO:0042981	regulation of apoptotic process
0.66	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway
0.64	GO:0032516	positive regulation of phosphoprotein phosphatase activity
0.61	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
0.61	GO:0035566	regulation of metanephros size
0.61	GO:0002035	brain renin-angiotensin system
0.61	GO:0003072	renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure

0.81	GO:0004945	angiotensin type II receptor activity
0.49	GO:0019956	chemokine binding
0.47	GO:0004950	chemokine receptor activity
0.45	GO:0005044	scavenger receptor activity
0.43	GO:0015026	coreceptor activity
0.40	GO:0017046	peptide hormone binding
0.38	GO:0016520	growth hormone-releasing hormone receptor activity
0.38	GO:0008134	transcription factor binding
0.37	GO:0001618	virus receptor activity
0.36	GO:0048019	receptor antagonist activity

0.39	GO:0048471	perinuclear region of cytoplasm
0.38	GO:0005886	plasma membrane
0.37	GO:0005768	endosome
0.35	GO:0005905	clathrin-coated pit
0.35	GO:0009986	cell surface
0.35	GO:0043005	neuron projection
0.34	GO:0005576	extracellular region
0.33	GO:0043231	intracellular membrane-bounded organelle
0.32	GO:0070013	intracellular organelle lumen
0.32	GO:0044446	intracellular organelle part

0.35

EC:2.7.11.14

GO:0050254

sp|P50053|KHK_HUMAN
Ketohexokinase
Search

KHK

0.94	Ketohexokinase

0.81	GO:0006000	fructose metabolic process
0.72	GO:0046835	carbohydrate phosphorylation
0.40	GO:0009744	response to sucrose
0.40	GO:0010043	response to zinc ion
0.40	GO:0009750	response to fructose
0.40	GO:0009749	response to glucose
0.40	GO:0032868	response to insulin
0.38	GO:0070873	regulation of glycogen metabolic process
0.37	GO:0019320	hexose catabolic process
0.36	GO:0019682	glyceraldehyde-3-phosphate metabolic process

0.86	GO:0004454	ketohexokinase activity
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding
0.34	GO:0004850	uridine phosphorylase activity

0.38	GO:0070062	extracellular exosome
0.37	GO:0005737	cytoplasm
0.35	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.86

EC:2.7.1.3

GO:0004454

sp|P50120|RET2_HUMAN
Retinol-binding protein 2
Search

RBP2

0.97	Cellular retinol-binding protein type II

0.48	GO:0006776	vitamin A metabolic process
0.46	GO:0002138	retinoic acid biosynthetic process
0.38	GO:0042572	retinol metabolic process
0.38	GO:0033189	response to vitamin A
0.38	GO:0030852	regulation of granulocyte differentiation
0.35	GO:0055088	lipid homeostasis
0.35	GO:0008544	epidermis development
0.34	GO:0060972	left/right pattern formation
0.34	GO:0061371	determination of heart left/right asymmetry
0.33	GO:0006886	intracellular protein transport

0.72	GO:0008289	lipid binding
0.42	GO:0043178	alcohol binding
0.38	GO:0019842	vitamin binding
0.36	GO:0016779	nucleotidyltransferase activity
0.33	GO:0005198	structural molecule activity
0.32	GO:0005515	protein binding

0.42	GO:0005829	cytosol
0.37	GO:0005811	lipid droplet
0.36	GO:0005654	nucleoplasm
0.36	GO:0044297	cell body
0.34	GO:0030663	COPI-coated vesicle membrane
0.33	GO:0030117	membrane coat
0.33	GO:0000139	Golgi membrane
0.32	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.36

GO:0016779

sp|P50135|HNMT_HUMAN
Histamine N-methyltransferase
Search

HNMT

0.97	Histamine N-methyltransferase A

0.63	GO:0001695	histamine catabolic process
0.61	GO:0032259	methylation
0.56	GO:1903955	positive regulation of protein targeting to mitochondrion
0.46	GO:0007420	brain development
0.40	GO:0002347	response to tumor cell
0.40	GO:0035902	response to immobilization stress
0.39	GO:0014075	response to amine
0.39	GO:0042220	response to cocaine
0.39	GO:0051384	response to glucocorticoid
0.39	GO:0070555	response to interleukin-1

0.69	GO:0008170	N-methyltransferase activity
0.50	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
0.37	GO:0098603	selenol Se-methyltransferase activity

0.45	GO:0043005	neuron projection
0.40	GO:0005737	cytoplasm
0.37	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.69

GO:0008170

sp|P50148|GNAQ_HUMAN
Guanine nucleotide-binding protein G(q) subunit alpha
Search

GNAQ

0.79	Guanine nucleotide binding protein q polypeptide

0.68	GO:0007186	G-protein coupled receptor signaling pathway
0.53	GO:0007603	phototransduction, visible light
0.52	GO:0009649	entrainment of circadian clock
0.51	GO:1905145	cellular response to acetylcholine
0.51	GO:1903831	signal transduction involved in cellular response to ammonium ion
0.47	GO:0001508	action potential
0.47	GO:0045634	regulation of melanocyte differentiation
0.46	GO:0042711	maternal behavior
0.46	GO:0019933	cAMP-mediated signaling
0.46	GO:0021884	forebrain neuron development

0.78	GO:0031683	G-protein beta/gamma-subunit complex binding
0.77	GO:0001664	G-protein coupled receptor binding
0.65	GO:0003924	GTPase activity
0.63	GO:0005525	GTP binding
0.62	GO:0004871	signal transducer activity
0.43	GO:0005096	GTPase activator activity
0.38	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity
0.36	GO:0046872	metal ion binding

0.52	GO:0001750	photoreceptor outer segment
0.44	GO:1905360	GTPase complex
0.44	GO:0030425	dendrite
0.44	GO:0044297	cell body
0.43	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.40	GO:0031965	nuclear membrane
0.40	GO:0098797	plasma membrane protein complex
0.37	GO:0005765	lysosomal membrane
0.36	GO:0070062	extracellular exosome
0.35	GO:0005901	caveola

0.38

EC:3.1.4.39

GO:0047391

sp|P50150|GBG4_HUMAN
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Search

GNG4

0.71	Guanine nucleotide-binding protein subunit gamma

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.52	GO:0030308	negative regulation of cell growth
0.42	GO:0008283	cell proliferation
0.42	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.42	GO:0002040	sprouting angiogenesis
0.37	GO:0071377	cellular response to glucagon stimulus
0.36	GO:0071380	cellular response to prostaglandin E stimulus
0.36	GO:0071870	cellular response to catecholamine stimulus
0.36	GO:0007040	lysosome organization
0.36	GO:0019933	cAMP-mediated signaling

0.64	GO:0004871	signal transducer activity
0.50	GO:0031681	G-protein beta-subunit binding
0.35	GO:0003924	GTPase activity

0.81	GO:1905360	GTPase complex
0.80	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.65	GO:0098797	plasma membrane protein complex
0.38	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

sp|P50151|GBG10_HUMAN
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
Search

GNG10

0.71	Guanine nucleotide-binding protein subunit gamma

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.43	GO:0043584	nose development
0.43	GO:0035176	social behavior
0.42	GO:0071444	cellular response to pheromone
0.37	GO:0071377	cellular response to glucagon stimulus
0.34	GO:0007399	nervous system development

0.64	GO:0004871	signal transducer activity
0.35	GO:0003924	GTPase activity
0.34	GO:0005515	protein binding
0.33	GO:0008146	sulfotransferase activity

0.81	GO:1905360	GTPase complex
0.80	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.65	GO:0098797	plasma membrane protein complex
0.38	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.33

GO:0008146

sp|P50213|IDH3A_HUMAN
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Search

IDH3A

0.64	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

0.69	GO:0006099	tricarboxylic acid cycle
0.35	GO:0006734	NADH metabolic process
0.34	GO:0006103	2-oxoglutarate metabolic process
0.34	GO:0006102	isocitrate metabolic process
0.33	GO:0005975	carbohydrate metabolic process

0.82	GO:0004449	isocitrate dehydrogenase (NAD+) activity
0.67	GO:0051287	NAD binding
0.64	GO:0000287	magnesium ion binding

0.59	GO:0005739	mitochondrion
0.50	GO:0043209	myelin sheath
0.35	GO:0045242	isocitrate dehydrogenase complex (NAD+)
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0005634	nucleus
0.33	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.82

EC:1.1.1.41

GO:0004449

sp|P50219|MNX1_HUMAN
Motor neuron and pancreas homeobox protein 1
Search

MNX1

0.79	Motor neuron and pancreas homeobox protein 1

0.60	GO:0021520	spinal cord motor neuron cell fate specification
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0031018	endocrine pancreas development
0.50	GO:0048812	neuron projection morphogenesis
0.46	GO:0035883	enteroendocrine cell differentiation
0.41	GO:0060539	diaphragm development
0.41	GO:0021904	dorsal/ventral neural tube patterning
0.40	GO:0021675	nerve development

0.64	GO:0043565	sequence-specific DNA binding
0.43	GO:0003700	DNA binding transcription factor activity
0.33	GO:0008241	peptidyl-dipeptidase activity
0.33	GO:0004000	adenosine deaminase activity
0.33	GO:0004672	protein kinase activity
0.33	GO:0004180	carboxypeptidase activity
0.32	GO:0008237	metallopeptidase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005634	nucleus
0.48	GO:0005829	cytosol
0.48	GO:0031974	membrane-enclosed lumen
0.44	GO:0043232	intracellular non-membrane-bounded organelle
0.43	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.33

EC:3.4.15

GO:0008241

sp|P50221|MEOX1_HUMAN
Homeobox protein MOX-1
Search

MEOX1

0.94	Homeobox protein MOX-1

0.70	GO:0001757	somite specification
0.66	GO:0061056	sclerotome development
0.61	GO:0006366	transcription by RNA polymerase II
0.61	GO:0045944	positive regulation of transcription by RNA polymerase II
0.52	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
0.51	GO:0070997	neuron death
0.50	GO:0061061	muscle structure development
0.50	GO:0060021	palate development
0.49	GO:0060173	limb development
0.49	GO:0014706	striated muscle tissue development

0.65	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.63	GO:0071837	HMG box domain binding
0.63	GO:0043565	sequence-specific DNA binding
0.61	GO:0001012	RNA polymerase II regulatory region DNA binding
0.60	GO:0001047	core promoter binding
0.58	GO:0003690	double-stranded DNA binding
0.57	GO:0003682	chromatin binding
0.52	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
0.50	GO:0035326	enhancer binding

0.61	GO:0005634	nucleus
0.43	GO:0005737	cytoplasm
0.35	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part

sp|P50222|MEOX2_HUMAN
Homeobox protein MOX-2
Search

MEOX2

0.97	Homeobox protein MOX-2

0.68	GO:0001757	somite specification
0.64	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
0.62	GO:0070997	neuron death
0.61	GO:0060021	palate development
0.60	GO:0007519	skeletal muscle tissue development
0.60	GO:0060173	limb development
0.59	GO:0006366	transcription by RNA polymerase II
0.59	GO:0001525	angiogenesis
0.59	GO:0045944	positive regulation of transcription by RNA polymerase II
0.47	GO:0061056	sclerotome development

0.63	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
0.63	GO:0043565	sequence-specific DNA binding
0.63	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.61	GO:0035326	enhancer binding
0.60	GO:0001012	RNA polymerase II regulatory region DNA binding
0.56	GO:0003690	double-stranded DNA binding
0.46	GO:0071837	HMG box domain binding
0.44	GO:0001047	core promoter binding
0.44	GO:0003682	chromatin binding

0.61	GO:0005634	nucleus
0.42	GO:0005737	cytoplasm
0.37	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part

sp|P50225|ST1A1_HUMAN
Sulfotransferase 1A1
Search

0.57	Sulfotransferase

0.47	GO:0051923	sulfation
0.46	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
0.45	GO:0006068	ethanol catabolic process
0.44	GO:0006584	catecholamine metabolic process
0.42	GO:0008202	steroid metabolic process
0.41	GO:0009812	flavonoid metabolic process
0.41	GO:0006805	xenobiotic metabolic process
0.39	GO:0000103	sulfate assimilation
0.38	GO:0042445	hormone metabolic process
0.36	GO:0098989	NMDA selective glutamate receptor signaling pathway

0.77	GO:0008146	sulfotransferase activity
0.36	GO:0005515	protein binding
0.36	GO:0043199	sulfate binding
0.35	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding

0.38

GO:0005829

cytosol

0.77

GO:0008146

sp|P50226|ST1A2_HUMAN
Sulfotransferase 1A2
Search

0.57	Sulfotransferase

0.47	GO:0051923	sulfation
0.46	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
0.45	GO:0006068	ethanol catabolic process
0.44	GO:0006584	catecholamine metabolic process
0.42	GO:0008202	steroid metabolic process
0.42	GO:0006805	xenobiotic metabolic process
0.41	GO:0009812	flavonoid metabolic process
0.39	GO:0042445	hormone metabolic process
0.38	GO:0000103	sulfate assimilation
0.36	GO:0098989	NMDA selective glutamate receptor signaling pathway

0.77	GO:0008146	sulfotransferase activity
0.36	GO:0005515	protein binding
0.36	GO:0043199	sulfate binding
0.35	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding

0.38

GO:0005829

cytosol

0.77

GO:0008146

sp|P50238|CRIP1_HUMAN
Cysteine-rich protein 1
Search

CRIP1

0.97	Cysteine-rich protein 1

0.56	GO:0071236	cellular response to antibiotic
0.56	GO:0071493	cellular response to UV-B
0.55	GO:0010043	response to zinc ion
0.54	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
0.44	GO:0060047	heart contraction
0.44	GO:0007507	heart development
0.41	GO:0060741	prostate gland stromal morphogenesis
0.37	GO:0006955	immune response
0.37	GO:0010033	response to organic substance
0.36	GO:0008283	cell proliferation

0.55	GO:0003680	AT DNA binding
0.54	GO:0008301	DNA binding, bending
0.54	GO:0046872	metal ion binding
0.51	GO:0042277	peptide binding

0.38

GO:0005737

cytoplasm

sp|P50281|MMP14_HUMAN
Matrix metalloproteinase-14
Search

MMP14

0.72	Membrane-type matrix metalloproteinase

0.78	GO:0030307	positive regulation of cell growth
0.75	GO:0030335	positive regulation of cell migration
0.60	GO:0045579	positive regulation of B cell differentiation
0.60	GO:0006508	proteolysis
0.59	GO:0010831	positive regulation of myotube differentiation
0.59	GO:0035988	chondrocyte proliferation
0.59	GO:0048701	embryonic cranial skeleton morphogenesis
0.59	GO:0097094	craniofacial suture morphogenesis
0.58	GO:1905521	regulation of macrophage migration
0.58	GO:0045746	negative regulation of Notch signaling pathway

0.69	GO:0004222	metalloendopeptidase activity
0.62	GO:0008270	zinc ion binding
0.53	GO:0070006	metalloaminopeptidase activity
0.40	GO:0005178	integrin binding
0.40	GO:0016504	peptidase activator activity
0.34	GO:0004252	serine-type endopeptidase activity

0.73	GO:0031012	extracellular matrix
0.60	GO:0044352	pinosome
0.54	GO:0045111	intermediate filament cytoskeleton
0.51	GO:0005615	extracellular space
0.49	GO:0005829	cytosol
0.46	GO:0005886	plasma membrane
0.45	GO:0005634	nucleus
0.43	GO:0042470	melanosome
0.38	GO:0005925	focal adhesion
0.36	GO:0005796	Golgi lumen

0.69

GO:0004222

sp|P50336|PPOX_HUMAN
Protoporphyrinogen oxidase
Search

PPOX

0.53	Protoporphyrinogen oxidase

0.72	GO:0006782	protoporphyrinogen IX biosynthetic process
0.52	GO:0055114	oxidation-reduction process
0.37	GO:0042493	response to drug

0.80	GO:0070818	protoporphyrinogen oxidase activity
0.74	GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
0.34	GO:0050660	flavin adenine dinucleotide binding

0.60	GO:0031966	mitochondrial membrane
0.60	GO:0019866	organelle inner membrane
0.54	GO:0031300	intrinsic component of organelle membrane
0.36	GO:0005758	mitochondrial intermembrane space
0.30	GO:0016021	integral component of membrane

0.74

EC:1.3.3

GO:0016634

sp|P50391|NPY4R_HUMAN
Neuropeptide Y receptor type 4
Search

0.97	Pancreatic polypeptide receptor 1

0.80	GO:0007218	neuropeptide signaling pathway
0.54	GO:0007631	feeding behavior
0.52	GO:0008015	blood circulation
0.48	GO:0007268	chemical synaptic transmission
0.47	GO:0003151	outflow tract morphogenesis
0.47	GO:0019233	sensory perception of pain
0.46	GO:0040014	regulation of multicellular organism growth
0.46	GO:0007626	locomotory behavior
0.42	GO:0006006	glucose metabolic process
0.40	GO:0065008	regulation of biological quality

0.84	GO:0004983	neuropeptide Y receptor activity
0.46	GO:0042923	neuropeptide binding
0.36	GO:0017046	peptide hormone binding
0.32	GO:0005515	protein binding
0.32	GO:0004966	galanin receptor activity

0.35	GO:0005886	plasma membrane
0.33	GO:0008021	synaptic vesicle
0.33	GO:0030424	axon
0.33	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

sp|P50395|GDIB_HUMAN
Rab GDP dissociation inhibitor beta
Search

GDI2

0.68	Rab GDP dissociation inhibitor beta

0.76	GO:0007264	small GTPase mediated signal transduction
0.75	GO:0043547	positive regulation of GTPase activity
0.65	GO:0015031	protein transport
0.49	GO:0090315	negative regulation of protein targeting to membrane
0.42	GO:0050771	negative regulation of axonogenesis
0.39	GO:0045773	positive regulation of axon extension
0.38	GO:0051592	response to calcium ion
0.36	GO:0016192	vesicle-mediated transport
0.35	GO:0051056	regulation of small GTPase mediated signal transduction
0.35	GO:0002283	neutrophil activation involved in immune response

0.85	GO:0005093	Rab GDP-dissociation inhibitor activity
0.75	GO:0005096	GTPase activator activity
0.40	GO:0031267	small GTPase binding
0.34	GO:0003723	RNA binding
0.33	GO:0003735	structural constituent of ribosome

0.53	GO:0043209	myelin sheath
0.48	GO:0005737	cytoplasm
0.45	GO:0030496	midbody
0.44	GO:0012505	endomembrane system
0.40	GO:0043231	intracellular membrane-bounded organelle
0.38	GO:0043025	neuronal cell body
0.38	GO:0030424	axon
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.35	GO:0031983	vesicle lumen

sp|P50402|EMD_HUMAN
Emerin
Search

EMD

0.97	Emd protein (Predicted)

0.70	GO:0035414	negative regulation of catenin import into nucleus
0.69	GO:0048147	negative regulation of fibroblast proliferation
0.68	GO:0046827	positive regulation of protein export from nucleus
0.65	GO:0060828	regulation of canonical Wnt signaling pathway
0.63	GO:0071363	cellular response to growth factor stimulus
0.63	GO:0035914	skeletal muscle cell differentiation
0.42	GO:0031468	nuclear envelope reassembly
0.40	GO:0007077	mitotic nuclear envelope disassembly
0.38	GO:0006936	muscle contraction
0.33	GO:0048168	regulation of neuronal synaptic plasticity

0.66	GO:0048487	beta-tubulin binding
0.64	GO:0045296	cadherin binding
0.59	GO:0003779	actin binding

0.76	GO:0005635	nuclear envelope
0.69	GO:0031616	spindle pole centrosome
0.68	GO:0032541	cortical endoplasmic reticulum
0.61	GO:0031968	organelle outer membrane
0.58	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.56	GO:0005654	nucleoplasm
0.51	GO:0019866	organelle inner membrane
0.40	GO:0005874	microtubule
0.38	GO:0005652	nuclear lamina
0.33	GO:0008021	synaptic vesicle

sp|P50406|5HT6R_HUMAN
5-hydroxytryptamine receptor 6
Search

HTR6

0.94	5-hydroxytryptamine receptor

0.71	GO:0098664	G-protein coupled serotonin receptor signaling pathway
0.58	GO:0021795	cerebral cortex cell migration
0.55	GO:0032008	positive regulation of TOR signaling
0.40	GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
0.38	GO:0071875	adrenergic receptor signaling pathway
0.37	GO:0019933	cAMP-mediated signaling
0.37	GO:0014058	negative regulation of acetylcholine secretion, neurotransmission
0.37	GO:0014053	negative regulation of gamma-aminobutyric acid secretion
0.36	GO:0014050	negative regulation of glutamate secretion
0.36	GO:0007267	cell-cell signaling

0.72	GO:0004930	G-protein coupled receptor activity
0.71	GO:0099589	serotonin receptor activity
0.64	GO:0030594	neurotransmitter receptor activity
0.36	GO:0005515	protein binding
0.34	GO:0001653	peptide receptor activity
0.34	GO:0051380	norepinephrine binding
0.33	GO:0044877	macromolecular complex binding
0.33	GO:0008373	sialyltransferase activity
0.32	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.32	GO:0042277	peptide binding

0.53	GO:0005929	cilium
0.37	GO:0005886	plasma membrane
0.35	GO:0030425	dendrite
0.35	GO:0061617	MICOS complex
0.33	GO:0043235	receptor complex
0.32	GO:0005840	ribosome

0.33

EC:2.4.99

GO:0008373

sp|P50416|CPT1A_HUMAN
Carnitine O-palmitoyltransferase 1, liver isoform
Search

CPT1A

0.89	Carnitine O-palmitoyltransferase

0.53	GO:0009437	carnitine metabolic process
0.51	GO:0001676	long-chain fatty acid metabolic process
0.51	GO:0030855	epithelial cell differentiation
0.42	GO:0032000	positive regulation of fatty acid beta-oxidation
0.42	GO:0042755	eating behavior
0.41	GO:0071398	cellular response to fatty acid
0.41	GO:0050796	regulation of insulin secretion
0.40	GO:0006641	triglyceride metabolic process
0.39	GO:0051260	protein homooligomerization
0.39	GO:0014070	response to organic cyclic compound

0.63	GO:0016746	transferase activity, transferring acyl groups
0.39	GO:0042802	identical protein binding

0.44	GO:0031966	mitochondrial membrane
0.44	GO:0019866	organelle inner membrane
0.40	GO:0031968	organelle outer membrane
0.39	GO:0031301	integral component of organelle membrane
0.34	GO:0005789	endoplasmic reticulum membrane
0.32	GO:0005840	ribosome

0.63

EC:2.3

GO:0016746

sp|P50440|GATM_HUMAN
Glycine amidinotransferase, mitochondrial
Search

GATM

0.88	LOW QUALITY PROTEIN: glycine amidinotransferase, mitochondrial

0.65	GO:0006601	creatine biosynthetic process
0.63	GO:0014889	muscle atrophy
0.58	GO:0007611	learning or memory
0.51	GO:0007275	multicellular organism development
0.36	GO:0042246	tissue regeneration
0.35	GO:0007584	response to nutrient
0.35	GO:0043434	response to peptide hormone
0.35	GO:0046689	response to mercury ion
0.34	GO:0006979	response to oxidative stress

0.84

GO:0015067

amidinotransferase activity

0.57	GO:0005758	mitochondrial intermembrane space
0.40	GO:0031966	mitochondrial membrane
0.40	GO:0019866	organelle inner membrane
0.37	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.84

EC:2.1.4

GO:0015067

sp|P50443|S26A2_HUMAN
Sulfate transporter
Search

SLC26A2

0.55	Sulfate transporter

0.77	GO:0001503	ossification
0.74	GO:1902358	sulfate transmembrane transport
0.60	GO:0019532	oxalate transport
0.55	GO:1902476	chloride transmembrane transport
0.50	GO:0015701	bicarbonate transport
0.49	GO:0051453	regulation of intracellular pH
0.47	GO:0042391	regulation of membrane potential
0.45	GO:0036269	swimming behavior
0.45	GO:0032474	otolith morphogenesis
0.45	GO:0048884	neuromast development

0.77	GO:0008271	secondary active sulfate transmembrane transporter activity
0.60	GO:0019531	oxalate transmembrane transporter activity
0.59	GO:0015301	anion:anion antiporter activity
0.56	GO:0015108	chloride transmembrane transporter activity
0.50	GO:0015106	bicarbonate transmembrane transporter activity
0.46	GO:0005253	anion channel activity
0.33	GO:0008270	zinc ion binding

0.55	GO:0005887	integral component of plasma membrane
0.39	GO:0031528	microvillus membrane
0.38	GO:0016324	apical plasma membrane
0.37	GO:0070062	extracellular exosome
0.32	GO:0005622	intracellular

sp|P50452|SPB8_HUMAN
Serpin B8
Search

SERPINB8

0.97	Serpin peptidase inhibitor, clade B (Ovalbumin), member 8

0.61	GO:0010951	negative regulation of endopeptidase activity
0.56	GO:0090136	epithelial cell-cell adhesion
0.49	GO:0042270	protection from natural killer cell mediated cytotoxicity
0.48	GO:0002448	mast cell mediated immunity
0.48	GO:0033668	negative regulation by symbiont of host apoptotic process
0.47	GO:0071391	cellular response to estrogen stimulus
0.46	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.44	GO:0043066	negative regulation of apoptotic process
0.44	GO:0006915	apoptotic process
0.44	GO:0009617	response to bacterium

0.63	GO:0004867	serine-type endopeptidase inhibitor activity
0.47	GO:0002020	protease binding
0.47	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

0.70	GO:0005615	extracellular space
0.51	GO:0005829	cytosol
0.43	GO:0005794	Golgi apparatus
0.42	GO:0005654	nucleoplasm
0.39	GO:1903561	extracellular vesicle
0.38	GO:0097180	serine protease inhibitor complex
0.36	GO:0101003	ficolin-1-rich granule membrane
0.36	GO:0070821	tertiary granule membrane
0.33	GO:0005886	plasma membrane

sp|P50453|SPB9_HUMAN
Serpin B9
Search

0.97	Cytoplasmic antiproteinase 3

0.66	GO:0010951	negative regulation of endopeptidase activity
0.55	GO:0042270	protection from natural killer cell mediated cytotoxicity
0.53	GO:0033668	negative regulation by symbiont of host apoptotic process
0.52	GO:0002448	mast cell mediated immunity
0.52	GO:0071391	cellular response to estrogen stimulus
0.50	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.48	GO:0043066	negative regulation of apoptotic process
0.48	GO:0006915	apoptotic process
0.48	GO:0009617	response to bacterium
0.47	GO:0006955	immune response

0.68	GO:0004867	serine-type endopeptidase inhibitor activity
0.52	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.51	GO:0002020	protease binding
0.33	GO:0008233	peptidase activity

0.73	GO:0005615	extracellular space
0.49	GO:0005829	cytosol
0.46	GO:0005794	Golgi apparatus
0.45	GO:0005654	nucleoplasm
0.38	GO:1903561	extracellular vesicle
0.37	GO:0097180	serine protease inhibitor complex
0.35	GO:0101003	ficolin-1-rich granule membrane
0.35	GO:0070821	tertiary granule membrane
0.33	GO:0031012	extracellular matrix
0.32	GO:0005886	plasma membrane

0.33

GO:0008233

sp|P50454|SERPH_HUMAN
Serpin H1
Search

SERPINH1

0.97	Serpin peptidase inhibitor clade H member 1

0.76	GO:0010951	negative regulation of endopeptidase activity
0.58	GO:0003433	chondrocyte development involved in endochondral bone morphogenesis
0.57	GO:0032964	collagen biosynthetic process
0.57	GO:0030199	collagen fibril organization
0.49	GO:0051604	protein maturation
0.45	GO:0031101	fin regeneration
0.35	GO:0006986	response to unfolded protein

0.83	GO:0005518	collagen binding
0.79	GO:0004867	serine-type endopeptidase inhibitor activity
0.48	GO:0051082	unfolded protein binding
0.34	GO:0003723	RNA binding

0.73	GO:0005615	extracellular space
0.56	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.54	GO:0045121	membrane raft
0.53	GO:0005783	endoplasmic reticulum
0.40	GO:0005581	collagen trimer
0.38	GO:0043233	organelle lumen
0.37	GO:1903561	extracellular vesicle
0.36	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

sp|P50458|LHX2_HUMAN
LIM/homeobox protein Lhx2
Search

LHX2

0.97	Lim homeobox transcription factor 2

0.65	GO:0021537	telencephalon development
0.64	GO:0045199	maintenance of epithelial cell apical/basal polarity
0.64	GO:0007411	axon guidance
0.64	GO:0043010	camera-type eye development
0.63	GO:0021871	forebrain regionalization
0.63	GO:2000678	negative regulation of transcription regulatory region DNA binding
0.62	GO:0048675	axon extension
0.62	GO:0001843	neural tube closure
0.61	GO:0007498	mesoderm development
0.60	GO:0009953	dorsal/ventral pattern formation

0.64	GO:0043565	sequence-specific DNA binding
0.60	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.57	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding
0.57	GO:0001012	RNA polymerase II regulatory region DNA binding
0.57	GO:0003682	chromatin binding
0.54	GO:0003690	double-stranded DNA binding
0.53	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.61

GO:0005634

nucleus

sp|P50461|CSRP3_HUMAN
Cysteine and glycine-rich protein 3
Search

CSRP3

0.91	Cysteine and glycine rich protein 3

0.55	GO:0060047	heart contraction
0.54	GO:0030239	myofibril assembly
0.51	GO:0035995	detection of muscle stretch
0.50	GO:0003300	cardiac muscle hypertrophy
0.49	GO:0006941	striated muscle contraction
0.48	GO:0002026	regulation of the force of heart contraction
0.48	GO:0055013	cardiac muscle cell development
0.46	GO:0006874	cellular calcium ion homeostasis
0.45	GO:0045944	positive regulation of transcription by RNA polymerase II
0.45	GO:0033365	protein localization to organelle

0.53	GO:0046872	metal ion binding
0.51	GO:0031433	telethonin binding
0.50	GO:0008307	structural constituent of muscle
0.46	GO:0042805	actinin binding
0.45	GO:0042802	identical protein binding
0.30	GO:0003779	actin binding

0.48	GO:0030018	Z disc
0.36	GO:0005634	nucleus
0.30	GO:0005856	cytoskeleton

sp|P50479|PDLI4_HUMAN
PDZ and LIM domain protein 4
Search

PDLIM4

0.97	PDZ and LIM domain protein 4

0.55	GO:0031532	actin cytoskeleton reorganization
0.45	GO:0098976	excitatory chemical synaptic transmission
0.40	GO:0098609	cell-cell adhesion
0.36	GO:0051496	positive regulation of stress fiber assembly
0.35	GO:2001141	regulation of RNA biosynthetic process
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0010468	regulation of gene expression
0.35	GO:0001666	response to hypoxia
0.35	GO:0060173	limb development
0.34	GO:0055085	transmembrane transport

0.61	GO:0051393	alpha-actinin binding
0.59	GO:0019903	protein phosphatase binding
0.54	GO:0042803	protein homodimerization activity
0.53	GO:0046872	metal ion binding
0.42	GO:0098641	cadherin binding involved in cell-cell adhesion
0.39	GO:0003713	transcription coactivator activity
0.34	GO:0051015	actin filament binding
0.34	GO:0022857	transmembrane transporter activity

0.60	GO:0097517	contractile actin filament bundle
0.60	GO:0031941	filamentous actin
0.60	GO:0042641	actomyosin
0.58	GO:0030027	lamellipodium
0.57	GO:0048471	perinuclear region of cytoplasm
0.47	GO:0005634	nucleus
0.45	GO:0034777	recycling endosome lumen
0.45	GO:0031905	early endosome lumen
0.43	GO:0030054	cell junction
0.42	GO:0055038	recycling endosome membrane

sp|P50502|F10A1_HUMAN
Hsc70-interacting protein
Search

ST13

0.92	Testis secretory sperm-binding protein Li 233m

0.43	GO:0061084	negative regulation of protein refolding
0.41	GO:0051289	protein homotetramerization
0.40	GO:0051085	chaperone cofactor-dependent protein refolding
0.33	GO:0006351	transcription, DNA-templated

0.65	GO:0046983	protein dimerization activity
0.43	GO:0032564	dATP binding
0.41	GO:0030544	Hsp70 protein binding
0.39	GO:0051087	chaperone binding
0.39	GO:0019904	protein domain specific binding
0.39	GO:0032403	protein complex binding
0.38	GO:0042802	identical protein binding
0.38	GO:0051082	unfolded protein binding
0.35	GO:0030674	protein binding, bridging

0.45	GO:0005829	cytosol
0.38	GO:0070062	extracellular exosome
0.36	GO:0043234	protein complex
0.33	GO:0005634	nucleus

sp|P50539|MXI1_HUMAN
Max-interacting protein 1
Search

MXI1

0.89	Max-interacting protein 1

0.41	GO:0000122	negative regulation of transcription by RNA polymerase II
0.38	GO:0042994	cytoplasmic sequestering of transcription factor
0.37	GO:0006351	transcription, DNA-templated
0.37	GO:0008285	negative regulation of cell proliferation

0.68	GO:0046983	protein dimerization activity
0.41	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.37	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.37	GO:0003714	transcription corepressor activity

0.40	GO:0005730	nucleolus
0.40	GO:0090575	RNA polymerase II transcription factor complex
0.39	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|P50542|PEX5_HUMAN
Peroxisomal targeting signal 1 receptor
Search

PEX5

0.92	Peroxisomal targeting signal 1 receptor

0.78	GO:0016558	protein import into peroxisome matrix
0.77	GO:0021895	cerebral cortex neuron differentiation
0.76	GO:0021795	cerebral cortex cell migration
0.75	GO:0040018	positive regulation of multicellular organism growth
0.74	GO:0050905	neuromuscular process
0.73	GO:0000038	very long-chain fatty acid metabolic process
0.73	GO:0001764	neuron migration
0.72	GO:0007029	endoplasmic reticulum organization
0.70	GO:0007006	mitochondrial membrane organization
0.68	GO:0006635	fatty acid beta-oxidation

0.71	GO:0005052	peroxisome matrix targeting signal-1 binding
0.49	GO:0008022	protein C-terminus binding
0.46	GO:0047485	protein N-terminus binding
0.43	GO:0031267	small GTPase binding

0.68	GO:0005829	cytosol
0.67	GO:0005794	Golgi apparatus
0.62	GO:0031903	microbody membrane
0.61	GO:0044439	peroxisomal part
0.54	GO:0005739	mitochondrion
0.52	GO:0031907	microbody lumen
0.38	GO:0043234	protein complex

sp|P50548|ERF_HUMAN
ETS domain-containing transcription factor ERF
Search

ERF

0.93	Ets2 repressor factor like 3

0.78	GO:0000122	negative regulation of transcription by RNA polymerase II
0.49	GO:0030154	cell differentiation
0.41	GO:0060710	chorio-allantoic fusion
0.41	GO:0007398	ectoderm development

0.81	GO:0003714	transcription corepressor activity
0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity

0.61	GO:0005634	nucleus
0.59	GO:0005829	cytosol
0.58	GO:0031974	membrane-enclosed lumen
0.50	GO:0044446	intracellular organelle part

sp|P50549|ETV1_HUMAN
ETS translocation variant 1
Search

ETV1

0.97	Ets transcription factor

0.85	GO:0048935	peripheral nervous system neuron development
0.75	GO:0006366	transcription by RNA polymerase II
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.52	GO:0007638	mechanosensory behavior
0.49	GO:0007517	muscle organ development
0.49	GO:0007411	axon guidance
0.48	GO:0051254	positive regulation of RNA metabolic process
0.48	GO:0010557	positive regulation of macromolecule biosynthetic process

0.64	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.50	GO:0001012	RNA polymerase II regulatory region DNA binding
0.48	GO:0003690	double-stranded DNA binding
0.33	GO:0005515	protein binding

0.61

GO:0005634

nucleus

sp|P50552|VASP_HUMAN
Vasodilator-stimulated phosphoprotein
Search

VASP

0.95	Vasodilator-stimulated phosphoprotein b

0.81	GO:0008154	actin polymerization or depolymerization
0.71	GO:0051289	protein homotetramerization
0.58	GO:0030838	positive regulation of actin filament polymerization
0.53	GO:0001843	neural tube closure
0.51	GO:0007411	axon guidance
0.41	GO:1900028	negative regulation of ruffle assembly
0.40	GO:0051496	positive regulation of stress fiber assembly
0.40	GO:0010633	negative regulation of epithelial cell migration
0.40	GO:0071346	cellular response to interferon-gamma
0.36	GO:0034329	cell junction assembly

0.67	GO:0017124	SH3 domain binding
0.62	GO:0003779	actin binding
0.56	GO:0005522	profilin binding
0.50	GO:0045296	cadherin binding

0.59	GO:0005856	cytoskeleton
0.56	GO:0042995	cell projection
0.53	GO:0005925	focal adhesion
0.53	GO:0031252	cell leading edge
0.46	GO:0005829	cytosol
0.41	GO:0005886	plasma membrane
0.39	GO:0005923	bicellular tight junction
0.39	GO:0045335	phagocytic vesicle
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

sp|P50553|ASCL1_HUMAN
Achaete-scute homolog 1
Search

ASCL1

0.29	Transcriptional regulator

0.70	GO:0006357	regulation of transcription by RNA polymerase II
0.59	GO:0061549	sympathetic ganglion development
0.59	GO:0035270	endocrine system development
0.59	GO:0030902	hindbrain development
0.58	GO:0003359	noradrenergic neuron fate commitment
0.58	GO:0060165	regulation of timing of subpallium neuron differentiation
0.58	GO:0061103	carotid body glomus cell differentiation
0.58	GO:0061102	stomach neuroendocrine cell differentiation
0.58	GO:0061100	lung neuroendocrine cell differentiation
0.57	GO:0060163	subpallium neuron fate commitment

0.68	GO:0046983	protein dimerization activity
0.59	GO:0070888	E-box binding
0.57	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.55	GO:0043425	bHLH transcription factor binding
0.50	GO:0000989	transcription factor activity, transcription factor binding
0.50	GO:0003682	chromatin binding
0.38	GO:0042802	identical protein binding

0.51	GO:0043025	neuronal cell body
0.47	GO:0090575	RNA polymerase II transcription factor complex
0.35	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|P50570|DYN2_HUMAN
Dynamin-2
Search

DNM2

0.94	Putative vacuolar sorting protein vps1 dynamin

0.71	GO:0006897	endocytosis
0.56	GO:1903526	negative regulation of membrane tubulation
0.54	GO:0033572	transferrin transport
0.53	GO:0060976	coronary vasculature development
0.53	GO:0035904	aorta development
0.52	GO:0003281	ventricular septum development
0.50	GO:0043112	receptor metabolic process
0.48	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission
0.46	GO:0000266	mitochondrial fission
0.43	GO:0060026	convergent extension

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.50	GO:0017124	SH3 domain binding
0.43	GO:0008017	microtubule binding
0.40	GO:0031749	D2 dopamine receptor binding
0.39	GO:0050998	nitric-oxide synthase binding
0.39	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding
0.39	GO:0050699	WW domain binding
0.37	GO:0019901	protein kinase binding
0.37	GO:0032403	protein complex binding

0.73	GO:0005874	microtubule
0.53	GO:0001917	photoreceptor inner segment
0.50	GO:0045211	postsynaptic membrane
0.46	GO:0005794	Golgi apparatus
0.45	GO:0005829	cytosol
0.40	GO:0030670	phagocytic vesicle membrane
0.40	GO:0001891	phagocytic cup
0.39	GO:0031966	mitochondrial membrane
0.39	GO:0030426	growth cone
0.39	GO:0014069	postsynaptic density

sp|P50579|MAP2_HUMAN
Methionine aminopeptidase 2
Search

METAP2

0.63	Methionine aminopeptidase 2

0.69	GO:0070084	protein initiator methionine removal
0.60	GO:0006508	proteolysis
0.57	GO:0018206	peptidyl-methionine modification
0.53	GO:0031365	N-terminal protein amino acid modification
0.50	GO:0051604	protein maturation
0.39	GO:0060218	hematopoietic stem cell differentiation
0.39	GO:0060216	definitive hemopoiesis
0.37	GO:0016055	Wnt signaling pathway
0.35	GO:0022400	regulation of rhodopsin mediated signaling pathway
0.34	GO:0045766	positive regulation of angiogenesis

0.73	GO:0008235	metalloexopeptidase activity
0.71	GO:0004177	aminopeptidase activity
0.53	GO:0046872	metal ion binding
0.34	GO:0003723	RNA binding
0.33	GO:0005515	protein binding
0.33	GO:0003700	DNA binding transcription factor activity
0.32	GO:0003677	DNA binding

0.48	GO:0005829	cytosol
0.42	GO:0005886	plasma membrane
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.71

EC:3.4.11

GO:0004177

sp|P50583|AP4A_HUMAN
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
Search

NUDT2

0.76	Nucleoside diphosphate-linked moiety X motif 2

0.39	GO:0015967	diadenosine tetraphosphate catabolic process
0.38	GO:0006915	apoptotic process
0.38	GO:0006172	ADP biosynthetic process
0.36	GO:0006167	AMP biosynthetic process
0.36	GO:0006754	ATP biosynthetic process
0.34	GO:0034599	cellular response to oxidative stress
0.32	GO:0051276	chromosome organization

0.82	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity
0.39	GO:0043135	5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity
0.37	GO:0032550	purine ribonucleoside binding
0.37	GO:0032561	guanyl ribonucleotide binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.44	GO:0005739	mitochondrion
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.32	GO:0005694	chromosome
0.32	GO:0005634	nucleus

0.82

EC:3.6.1

GO:0008796

sp|P50591|TNF10_HUMAN
Tumor necrosis factor ligand superfamily member 10
Search

TNFSF10

0.93	Tumor necrosis factor related apoptosis inducing ligand

0.74	GO:0010469	regulation of receptor activity
0.73	GO:0006955	immune response
0.53	GO:0090200	positive regulation of release of cytochrome c from mitochondria
0.52	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
0.51	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.51	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.43	GO:0008584	male gonad development
0.43	GO:0032868	response to insulin
0.39	GO:0006915	apoptotic process
0.39	GO:2001267	regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

0.83	GO:0005164	tumor necrosis factor receptor binding
0.79	GO:0005125	cytokine activity
0.52	GO:0046872	metal ion binding
0.47	GO:0042802	identical protein binding
0.33	GO:0005174	CD40 receptor binding

0.72	GO:0005615	extracellular space
0.39	GO:1903561	extracellular vesicle
0.35	GO:0005887	integral component of plasma membrane
0.32	GO:0009897	external side of plasma membrane
0.31	GO:0005622	intracellular

sp|P50607|TUB_HUMAN
Tubby protein homolog
Search

TUB

0.90	Tubby bipartite transcription factor

0.87	GO:0097500	receptor localization to non-motile cilium
0.87	GO:1903546	protein localization to photoreceptor outer segment
0.85	GO:0050766	positive regulation of phagocytosis
0.84	GO:0006910	phagocytosis, recognition
0.84	GO:0045494	photoreceptor cell maintenance
0.81	GO:0060041	retina development in camera-type eye
0.79	GO:0007605	sensory perception of sound
0.59	GO:0009725	response to hormone

0.75	GO:0032403	protein complex binding
0.68	GO:0035091	phosphatidylinositol binding

0.68	GO:0005929	cilium
0.66	GO:0005829	cytosol
0.64	GO:0005576	extracellular region
0.50	GO:0005634	nucleus
0.47	GO:0005886	plasma membrane

sp|P50613|CDK7_HUMAN
Cyclin-dependent kinase 7
Search

CDK7

0.95	Cell division protein kinase 7

0.61	GO:0006468	protein phosphorylation
0.54	GO:0050821	protein stabilization
0.53	GO:0045944	positive regulation of transcription by RNA polymerase II
0.52	GO:0006366	transcription by RNA polymerase II
0.45	GO:0051726	regulation of cell cycle
0.42	GO:0051301	cell division
0.37	GO:0007049	cell cycle
0.36	GO:0022414	reproductive process
0.36	GO:0006294	nucleotide-excision repair, preincision complex assembly
0.36	GO:1900195	positive regulation of oocyte maturation

0.80	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.55	GO:0008022	protein C-terminus binding
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0004693	cyclin-dependent protein serine/threonine kinase activity
0.49	GO:0008094	DNA-dependent ATPase activity
0.35	GO:0050681	androgen receptor binding
0.35	GO:0003713	transcription coactivator activity
0.34	GO:0032403	protein complex binding

0.80	GO:0070985	TFIIK complex
0.58	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex
0.37	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0042585	germinal vesicle
0.34	GO:0005856	cytoskeleton
0.34	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.80

EC:2.7.11.23

GO:0008353

sp|P50616|TOB1_HUMAN
Protein Tob1
Search

TOB1

0.91	Putative anti-proliferation factor btg1/tob

0.79	GO:0008285	negative regulation of cell proliferation
0.62	GO:0060212	negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
0.59	GO:0007184	SMAD protein import into nucleus
0.59	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
0.57	GO:0045668	negative regulation of osteoblast differentiation
0.56	GO:0030514	negative regulation of BMP signaling pathway
0.52	GO:0017148	negative regulation of translation
0.51	GO:1903507	negative regulation of nucleic acid-templated transcription
0.50	GO:0030509	BMP signaling pathway
0.41	GO:0060070	canonical Wnt signaling pathway

0.57	GO:0030971	receptor tyrosine kinase binding
0.56	GO:0046332	SMAD binding
0.55	GO:0003714	transcription corepressor activity
0.35	GO:0005070	SH3/SH2 adaptor activity

0.55	GO:0030014	CCR4-NOT complex
0.42	GO:0005634	nucleus
0.40	GO:0005737	cytoplasm

sp|P50747|BPL1_HUMAN
Biotin--protein ligase
Search

HLCS

0.72	Holocarboxylase synthetase

0.75	GO:0070781	response to biotin
0.75	GO:0071110	histone biotinylation
0.64	GO:0008283	cell proliferation

0.79	GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity
0.75	GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
0.66	GO:0009374	biotin binding
0.59	GO:0019899	enzyme binding
0.39	GO:0042803	protein homodimerization activity

0.71	GO:0005652	nuclear lamina
0.68	GO:0016363	nuclear matrix
0.59	GO:0000785	chromatin
0.57	GO:0005829	cytosol
0.50	GO:0005739	mitochondrion

0.79

EC:6.3.4.15

GO:0004077

sp|P50748|KNTC1_HUMAN
Kinetochore-associated protein 1
Search

KNTC1

0.94	Kinetochore associated 1

0.80

GO:0007093

mitotic cell cycle checkpoint

0.86	GO:1990423	RZZ complex
0.85	GO:0005828	kinetochore microtubule
0.80	GO:0000922	spindle pole
0.74	GO:0015629	actin cytoskeleton
0.69	GO:0005829	cytosol
0.56	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P50749|RASF2_HUMAN
Ras association domain-containing protein 2
Search

RASSF2

0.97	Ras association domain-containing protein 2

0.69	GO:0042981	regulation of apoptotic process
0.61	GO:0038167	epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity
0.59	GO:0033137	negative regulation of peptidyl-serine phosphorylation
0.58	GO:1901223	negative regulation of NIK/NF-kappaB signaling
0.58	GO:0031954	positive regulation of protein autophosphorylation
0.57	GO:0046849	bone remodeling
0.56	GO:0046330	positive regulation of JNK cascade
0.56	GO:0045670	regulation of osteoclast differentiation
0.56	GO:0045667	regulation of osteoblast differentiation
0.55	GO:0001503	ossification

0.46	GO:0004672	protein kinase activity
0.35	GO:0005515	protein binding
0.34	GO:0070890	sodium-dependent L-ascorbate transmembrane transporter activity

0.53	GO:0000776	kinetochore
0.50	GO:0005794	Golgi apparatus
0.49	GO:0005654	nucleoplasm
0.48	GO:0005829	cytosol
0.42	GO:0005886	plasma membrane
0.38	GO:0000779	condensed chromosome, centromeric region
0.30	GO:0016021	integral component of membrane

sp|P50750|CDK9_HUMAN
Cyclin-dependent kinase 9
Search

CDK9

0.92	Cell division protein kinase 9

0.62	GO:0006468	protein phosphorylation
0.56	GO:1903839	positive regulation of mRNA 3'-UTR binding
0.55	GO:0033129	positive regulation of histone phosphorylation
0.55	GO:2001168	positive regulation of histone H2B ubiquitination
0.54	GO:1900364	negative regulation of mRNA polyadenylation
0.53	GO:0071157	negative regulation of cell cycle arrest
0.52	GO:0051147	regulation of muscle cell differentiation
0.52	GO:0031297	replication fork processing
0.50	GO:0045944	positive regulation of transcription by RNA polymerase II
0.49	GO:0006282	regulation of DNA repair

0.64	GO:0004674	protein serine/threonine kinase activity
0.54	GO:0097322	7SK snRNA binding
0.54	GO:0097472	cyclin-dependent protein kinase activity
0.54	GO:0001223	transcription coactivator binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.49	GO:0019901	protein kinase binding

0.56	GO:0008024	cyclin/CDK positive transcription elongation factor complex
0.52	GO:0016605	PML body
0.50	GO:0036464	cytoplasmic ribonucleoprotein granule
0.42	GO:0005694	chromosome
0.30	GO:0016020	membrane

0.64

GO:0004674

sp|P50851|LRBA_HUMAN
Lipopolysaccharide-responsive and beige-like anchor protein
Search

LRBA

0.94	LPS-responsive vesicle trafficking, beach and anchor containing

0.76	GO:1990823	response to leukemia inhibitory factor
0.71	GO:0071345	cellular response to cytokine stimulus
0.51	GO:0016197	endosomal transport
0.47	GO:0008104	protein localization
0.43	GO:0007165	signal transduction
0.35	GO:0055114	oxidation-reduction process

0.54	GO:0051018	protein kinase A binding
0.42	GO:0019901	protein kinase binding
0.38	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

0.76	GO:0005764	lysosome
0.73	GO:0005802	trans-Golgi network
0.68	GO:0005783	endoplasmic reticulum
0.65	GO:0031410	cytoplasmic vesicle
0.55	GO:0005886	plasma membrane
0.40	GO:0005829	cytosol
0.30	GO:0044425	membrane part

0.38

GO:0016620

sp|P50876|R144A_HUMAN
E3 ubiquitin-protein ligase RNF144A
Search

RNF144A

0.58	RING-type E3 ubiquitin transferase

0.72	GO:0016567	protein ubiquitination
0.49	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.47	GO:0006511	ubiquitin-dependent protein catabolic process
0.40	GO:0043066	negative regulation of apoptotic process
0.34	GO:0051607	defense response to virus
0.33	GO:0006915	apoptotic process

0.73	GO:0004842	ubiquitin-protein transferase activity
0.53	GO:0046872	metal ion binding
0.51	GO:0016874	ligase activity
0.50	GO:0031624	ubiquitin conjugating enzyme binding
0.47	GO:0061659	ubiquitin-like protein ligase activity
0.33	GO:0051536	iron-sulfur cluster binding

0.49	GO:0005794	Golgi apparatus
0.46	GO:0000151	ubiquitin ligase complex
0.38	GO:0031090	organelle membrane
0.37	GO:0044446	intracellular organelle part
0.37	GO:0005739	mitochondrion
0.37	GO:0031975	envelope
0.35	GO:0031410	cytoplasmic vesicle
0.34	GO:0005811	lipid droplet
0.34	GO:0098805	whole membrane
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network

0.51	EC:6	GO:0016874
0.73	KEGG:R03876	GO:0004842

sp|P50895|BCAM_HUMAN
Basal cell adhesion molecule
Search

BCAM

0.96	Basal cell adhesion molecule

0.61	GO:0007160	cell-matrix adhesion
0.35	GO:0007165	signal transduction

0.67	GO:0005055	laminin receptor activity
0.64	GO:0043236	laminin binding
0.62	GO:0008022	protein C-terminus binding
0.37	GO:0099600	transmembrane receptor activity
0.36	GO:0038023	signaling receptor activity

0.57	GO:0009986	cell surface
0.56	GO:0031012	extracellular matrix
0.45	GO:0005886	plasma membrane
0.41	GO:0070062	extracellular exosome
0.37	GO:0098552	side of membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P50897|PPT1_HUMAN
Palmitoyl-protein thioesterase 1
Search

PPT1

0.84	Palmitoyl-protein thioesterase

0.84	GO:0002084	protein depalmitoylation
0.57	GO:0032429	regulation of phospholipase A2 activity
0.57	GO:0007625	grooming behavior
0.56	GO:0007040	lysosome organization
0.55	GO:0008306	associative learning
0.54	GO:0008344	adult locomotory behavior
0.53	GO:0099643	signal release from synapse
0.53	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.52	GO:0007601	visual perception
0.50	GO:0006836	neurotransmitter transport

0.84	GO:0008474	palmitoyl-(protein) hydrolase activity
0.43	GO:0016290	palmitoyl-CoA hydrolase activity
0.35	GO:0005515	protein binding

0.55	GO:0005764	lysosome
0.54	GO:0030424	axon
0.53	GO:0098793	presynapse
0.53	GO:0043025	neuronal cell body
0.53	GO:0030425	dendrite
0.50	GO:0005615	extracellular space
0.42	GO:0070382	exocytic vesicle
0.41	GO:0045121	membrane raft
0.39	GO:0005794	Golgi apparatus
0.39	GO:0005829	cytosol

0.84

EC:3.1.2.22

GO:0008474

sp|P50914|RL14_HUMAN
60S ribosomal protein L14
Search

RPL14

0.58	Ribosomal protein L14

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.50	GO:0042273	ribosomal large subunit biogenesis
0.43	GO:0016072	rRNA metabolic process
0.35	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.35	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.34	GO:0019083	viral transcription

0.64	GO:0003735	structural constituent of ribosome
0.47	GO:0045296	cadherin binding
0.40	GO:0003723	RNA binding
0.32	GO:0016787	hydrolase activity

0.61	GO:0005840	ribosome
0.44	GO:0044445	cytosolic part
0.39	GO:0044446	intracellular organelle part
0.37	GO:0070062	extracellular exosome
0.33	GO:0005791	rough endoplasmic reticulum
0.33	GO:0098562	cytoplasmic side of membrane
0.33	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.32	GO:0098588	bounding membrane of organelle
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016787

sp|P50990|TCPQ_HUMAN
T-complex protein 1 subunit theta
Search

CCT8

0.79	Chaperonin containing TCP-1 theta subunit

0.69	GO:0006457	protein folding
0.54	GO:1904869	regulation of protein localization to Cajal body
0.53	GO:1904851	positive regulation of establishment of protein localization to telomere
0.53	GO:1904874	positive regulation of telomerase RNA localization to Cajal body
0.52	GO:0032212	positive regulation of telomere maintenance via telomerase
0.52	GO:0046931	pore complex assembly
0.51	GO:0007339	binding of sperm to zona pellucida
0.51	GO:1900182	positive regulation of protein localization to nucleus
0.49	GO:0050821	protein stabilization
0.49	GO:1901998	toxin transport

0.71	GO:0051082	unfolded protein binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0045296	cadherin binding
0.47	GO:0044183	protein binding involved in protein folding
0.33	GO:0042623	ATPase activity, coupled

0.55	GO:0005832	chaperonin-containing T-complex
0.53	GO:0002199	zona pellucida receptor complex
0.49	GO:0044297	cell body
0.49	GO:0005815	microtubule organizing center
0.49	GO:0045111	intermediate filament cytoskeleton
0.47	GO:0005874	microtubule
0.45	GO:0005654	nucleoplasm
0.38	GO:0005929	cilium
0.36	GO:0070062	extracellular exosome
0.35	GO:1904813	ficolin-1-rich granule lumen

sp|P50991|TCPD_HUMAN
T-complex protein 1 subunit delta
Search

CCT4

0.70	T-complex protein 1 subunit delta

0.68	GO:0006457	protein folding
0.58	GO:0090670	RNA localization to Cajal body
0.57	GO:1904869	regulation of protein localization to Cajal body
0.57	GO:1904851	positive regulation of establishment of protein localization to telomere
0.56	GO:1904874	positive regulation of telomerase RNA localization to Cajal body
0.56	GO:0051973	positive regulation of telomerase activity
0.55	GO:0032212	positive regulation of telomere maintenance via telomerase
0.54	GO:0007339	binding of sperm to zona pellucida
0.54	GO:1900182	positive regulation of protein localization to nucleus
0.52	GO:0050821	protein stabilization

0.71	GO:0051082	unfolded protein binding
0.54	GO:0030554	adenyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0044183	protein binding involved in protein folding
0.34	GO:0003723	RNA binding

0.59	GO:0005832	chaperonin-containing T-complex
0.55	GO:0002199	zona pellucida receptor complex
0.51	GO:0005813	centrosome
0.51	GO:0044297	cell body
0.49	GO:0005874	microtubule
0.48	GO:0005654	nucleoplasm
0.40	GO:0042470	melanosome
0.38	GO:0005929	cilium
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

sp|P50993|AT1A2_HUMAN
Sodium/potassium-transporting ATPase subunit alpha-2
Search

ATP1A2

0.64	Sodium/potassium-transporting ATPase subunit alpha

0.84	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
0.75	GO:0090662	ATP hydrolysis coupled transmembrane transport
0.72	GO:0006814	sodium ion transport
0.71	GO:0006813	potassium ion transport
0.60	GO:0006883	cellular sodium ion homeostasis
0.58	GO:0008542	visual learning
0.57	GO:0007626	locomotory behavior
0.57	GO:0030007	cellular potassium ion homeostasis
0.56	GO:0140115	export across plasma membrane
0.56	GO:0030534	adult behavior

0.85	GO:0005391	sodium:potassium-exchanging ATPase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.53	GO:0046872	metal ion binding
0.53	GO:1990239	steroid hormone binding
0.52	GO:0051087	chaperone binding
0.48	GO:0001540	amyloid-beta binding
0.44	GO:1901681	sulfur compound binding

0.57	GO:0005890	sodium:potassium-exchanging ATPase complex
0.57	GO:0042383	sarcolemma
0.56	GO:0043209	myelin sheath
0.48	GO:0036477	somatodendritic compartment
0.47	GO:0043005	neuron projection
0.46	GO:0044297	cell body
0.44	GO:0012505	endomembrane system
0.42	GO:0098794	postsynapse
0.41	GO:0005634	nucleus
0.40	GO:0014704	intercalated disc

0.85

GO:0005391

sp|P50995|ANX11_HUMAN
Annexin A11
Search

ANXA11

0.60

Annexin

0.54	GO:0051592	response to calcium ion
0.54	GO:0006909	phagocytosis
0.50	GO:0032506	cytokinetic process
0.33	GO:0050819	negative regulation of coagulation

0.81	GO:0005544	calcium-dependent phospholipid binding
0.70	GO:0005509	calcium ion binding
0.56	GO:0044548	S100 protein binding
0.56	GO:0008429	phosphatidylethanolamine binding
0.55	GO:0048306	calcium-dependent protein binding
0.39	GO:0023026	MHC class II protein complex binding
0.34	GO:0003723	RNA binding

0.56	GO:0005766	primary lysosome
0.56	GO:0042581	specific granule
0.54	GO:0030496	midbody
0.54	GO:0045335	phagocytic vesicle
0.51	GO:0005819	spindle
0.51	GO:0005635	nuclear envelope
0.49	GO:0005654	nucleoplasm
0.48	GO:0005829	cytosol
0.40	GO:0042470	melanosome
0.37	GO:0070062	extracellular exosome

sp|P51003|PAPOA_HUMAN
Poly(A) polymerase alpha
Search

PAPOLA

0.60	Poly (A) polymerase alpha

0.78	GO:0043631	RNA polyadenylation
0.74	GO:0031123	RNA 3'-end processing
0.52	GO:0031440	regulation of mRNA 3'-end processing
0.48	GO:0006397	mRNA processing
0.35	GO:0006369	termination of RNA polymerase II transcription
0.34	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

0.76	GO:0004652	polynucleotide adenylyltransferase activity
0.58	GO:0003723	RNA binding
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0046872	metal ion binding
0.35	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.45	GO:0031974	membrane-enclosed lumen
0.41	GO:0044446	intracellular organelle part
0.36	GO:0005737	cytoplasm
0.34	GO:0012505	endomembrane system
0.30	GO:0031224	intrinsic component of membrane

0.76

EC:2.7.7.19

GO:0004652

sp|P51114|FXR1_HUMAN
Fragile X mental retardation syndrome-related protein 1
Search

FXR1

0.93	FMR1 autosomal homolog 1

0.68	GO:2000637	positive regulation of gene silencing by miRNA
0.62	GO:0007517	muscle organ development
0.59	GO:0017148	negative regulation of translation
0.37	GO:0001756	somitogenesis
0.37	GO:0048747	muscle fiber development
0.36	GO:0014706	striated muscle tissue development
0.36	GO:0007507	heart development

0.66	GO:0033592	RNA strand annealing activity
0.65	GO:0002151	G-quadruplex RNA binding
0.63	GO:0003730	mRNA 3'-UTR binding
0.59	GO:0042803	protein homodimerization activity
0.59	GO:0046982	protein heterodimerization activity

0.67	GO:0043034	costamere
0.64	GO:0043197	dendritic spine
0.63	GO:0005844	polysome
0.61	GO:0030424	axon
0.61	GO:0048471	perinuclear region of cytoplasm
0.60	GO:0035770	ribonucleoprotein granule
0.55	GO:0005829	cytosol
0.49	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P51116|FXR2_HUMAN
Fragile X mental retardation syndrome-related protein 2
Search

FXR2

0.93	Fragile X mental retardation, autosomal homolog 2

0.50	GO:0017148	negative regulation of translation
0.48	GO:2000637	positive regulation of gene silencing by miRNA
0.46	GO:0007517	muscle organ development
0.38	GO:0030154	cell differentiation
0.36	GO:0001756	somitogenesis
0.36	GO:0014706	striated muscle tissue development
0.36	GO:0007507	heart development

0.59	GO:0003723	RNA binding
0.55	GO:0042803	protein homodimerization activity
0.55	GO:0046982	protein heterodimerization activity
0.47	GO:0097617	annealing activity
0.35	GO:0008080	N-acetyltransferase activity
0.33	GO:0003677	DNA binding

0.53	GO:0005844	polysome
0.51	GO:0005829	cytosol
0.46	GO:0043034	costamere
0.45	GO:0030425	dendrite
0.45	GO:0044309	neuron spine
0.44	GO:0005634	nucleus
0.43	GO:0030424	axon
0.43	GO:0048471	perinuclear region of cytoplasm
0.43	GO:0035770	ribonucleoprotein granule
0.43	GO:0098794	postsynapse

0.35

GO:0008080

sp|P51124|GRAM_HUMAN
Granzyme M
Search

0.41	Complement factor D

0.61	GO:0006508	proteolysis
0.60	GO:0008219	cell death
0.53	GO:0006957	complement activation, alternative pathway
0.50	GO:0019835	cytolysis
0.41	GO:0051604	protein maturation
0.39	GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
0.38	GO:0051239	regulation of multicellular organismal process
0.38	GO:0030154	cell differentiation
0.37	GO:0048731	system development
0.37	GO:0072672	neutrophil extravasation

0.69	GO:0004252	serine-type endopeptidase activity
0.40	GO:0008201	heparin binding
0.39	GO:0005515	protein binding
0.36	GO:0030552	cAMP binding
0.35	GO:0005249	voltage-gated potassium channel activity
0.34	GO:0001106	RNA polymerase II transcription corepressor activity
0.32	GO:0046872	metal ion binding

0.48	GO:0030141	secretory granule
0.48	GO:0005615	extracellular space
0.43	GO:0060205	cytoplasmic vesicle lumen
0.42	GO:0005766	primary lysosome
0.42	GO:0005775	vacuolar lumen
0.37	GO:1903561	extracellular vesicle
0.36	GO:0044853	plasma membrane raft
0.36	GO:0097180	serine protease inhibitor complex
0.35	GO:0031012	extracellular matrix
0.35	GO:0005829	cytosol

0.69

GO:0004252

sp|P51148|RAB5C_HUMAN
Ras-related protein Rab-5C
Search

RAB5C

0.93	Lysine acetyltransferase 2A

0.57	GO:0048227	plasma membrane to endosome transport
0.49	GO:0030100	regulation of endocytosis
0.41	GO:0007032	endosome organization
0.40	GO:0001702	gastrulation with mouth forming second
0.39	GO:0001525	angiogenesis
0.38	GO:0098609	cell-cell adhesion
0.38	GO:0002376	immune system process
0.37	GO:0015031	protein transport
0.36	GO:0034765	regulation of ion transmembrane transport
0.35	GO:0023014	signal transduction by protein phosphorylation

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0030742	GTP-dependent protein binding
0.36	GO:0005216	ion channel activity
0.36	GO:0022832	voltage-gated channel activity
0.35	GO:0000155	phosphorelay sensor kinase activity
0.35	GO:0015079	potassium ion transmembrane transporter activity

0.54	GO:0005768	endosome
0.51	GO:0005811	lipid droplet
0.48	GO:0030139	endocytic vesicle
0.40	GO:0044433	cytoplasmic vesicle part
0.40	GO:0070062	extracellular exosome
0.40	GO:0098805	whole membrane
0.39	GO:0098588	bounding membrane of organelle
0.39	GO:0042470	melanosome
0.39	GO:0005886	plasma membrane
0.38	GO:0070382	exocytic vesicle

0.35

EC:2.7.3

GO:0000155

sp|P51149|RAB7A_HUMAN
Ras-related protein Rab-7a
Search

RAB7A

0.94	RAB7A, member RAS oncogene family

0.58	GO:0061724	lipophagy
0.57	GO:0007174	epidermal growth factor catabolic process
0.56	GO:0090383	phagosome acidification
0.56	GO:0090385	phagosome-lysosome fusion
0.56	GO:1903542	negative regulation of exosomal secretion
0.55	GO:0022615	protein to membrane docking
0.55	GO:0045022	early endosome to late endosome transport
0.54	GO:1903543	positive regulation of exosomal secretion
0.54	GO:0006622	protein targeting to lysosome
0.53	GO:0008333	endosome to lysosome transport

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.56	GO:1905394	retromer complex binding
0.53	GO:0019003	GDP binding
0.40	GO:0048365	Rac GTPase binding

0.57	GO:0032419	extrinsic component of lysosome membrane
0.55	GO:0005770	late endosome
0.53	GO:0045335	phagocytic vesicle
0.52	GO:0005811	lipid droplet
0.52	GO:0034045	phagophore assembly site membrane
0.51	GO:0010008	endosome membrane
0.51	GO:0030904	retromer complex
0.47	GO:0005794	Golgi apparatus
0.47	GO:0005829	cytosol
0.42	GO:0033162	melanosome membrane

sp|P51151|RAB9A_HUMAN
Ras-related protein Rab-9A
Search

RAB9A

0.93	Ras-related protein Rab-9A

0.44	GO:0052405	negative regulation by host of symbiont molecular function
0.43	GO:0042147	retrograde transport, endosome to Golgi
0.42	GO:0045921	positive regulation of exocytosis
0.40	GO:0032880	regulation of protein localization
0.38	GO:0015031	protein transport
0.33	GO:0006351	transcription, DNA-templated

0.66	GO:0003924	GTPase activity
0.64	GO:0005525	GTP binding
0.46	GO:0019003	GDP binding
0.42	GO:0042802	identical protein binding

0.45	GO:0045335	phagocytic vesicle
0.43	GO:0030666	endocytic vesicle membrane
0.42	GO:0042470	melanosome
0.41	GO:0005770	late endosome
0.41	GO:0005764	lysosome
0.40	GO:0005829	cytosol
0.39	GO:0000139	Golgi membrane
0.39	GO:0005789	endoplasmic reticulum membrane
0.37	GO:0070062	extracellular exosome
0.36	GO:0005886	plasma membrane

sp|P51153|RAB13_HUMAN
Ras-related protein Rab-13
Search

RAB13

0.81	LOW QUALITY PROTEIN: ras-related protein Rab-13

0.57	GO:1902463	protein localization to cell leading edge
0.55	GO:0010737	protein kinase A signaling
0.55	GO:0035767	endothelial cell chemotaxis
0.54	GO:0070830	bicellular tight junction assembly
0.53	GO:0072659	protein localization to plasma membrane
0.53	GO:0032456	endocytic recycling
0.50	GO:0031175	neuron projection development
0.46	GO:0061865	polarized secretion of basement membrane proteins in epithelium
0.45	GO:0044795	trans-Golgi network to recycling endosome transport
0.43	GO:0008582	regulation of synaptic growth at neuromuscular junction

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.38	GO:0034236	protein kinase A catalytic subunit binding
0.36	GO:0071532	ankyrin repeat binding
0.36	GO:0032794	GTPase activating protein binding
0.34	GO:0019003	GDP binding

0.56	GO:0055037	recycling endosome
0.53	GO:0016328	lateral plasma membrane
0.52	GO:0097458	neuron part
0.52	GO:0030027	lamellipodium
0.52	GO:0030139	endocytic vesicle
0.51	GO:0005923	bicellular tight junction
0.51	GO:0005802	trans-Golgi network
0.45	GO:0005829	cytosol
0.43	GO:0030141	secretory granule
0.42	GO:0030659	cytoplasmic vesicle membrane

sp|P51157|RAB28_HUMAN
Ras-related protein Rab-28
Search

RAB28

0.97	LOW QUALITY PROTEIN: ras-related protein Rab-28-like

0.48

GO:1901998

toxin transport

0.67	GO:0003924	GTPase activity
0.65	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.54	GO:0032553	ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.42	GO:0035253	ciliary rootlet
0.41	GO:0036064	ciliary basal body
0.35	GO:0005886	plasma membrane
0.34	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|P51159|RB27A_HUMAN
Ras-related protein Rab-27A
Search

RAB27A

0.91	Putative rab subfamily protein of small gtpase

0.62	GO:0045921	positive regulation of exocytosis
0.61	GO:0032400	melanosome localization
0.60	GO:0097278	complement-dependent cytotoxicity
0.60	GO:1903433	regulation of constitutive secretory pathway
0.59	GO:0051904	pigment granule transport
0.58	GO:1990182	exosomal secretion
0.58	GO:0071985	multivesicular body sorting pathway
0.58	GO:0043316	cytotoxic T cell degranulation
0.57	GO:0036257	multivesicular body organization
0.57	GO:0043320	natural killer cell degranulation

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0032561	guanyl ribonucleotide binding
0.61	GO:0031489	myosin V binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0019904	protein domain specific binding

0.63	GO:0032585	multivesicular body membrane
0.62	GO:0042470	melanosome
0.57	GO:0099503	secretory vesicle
0.56	GO:0030133	transport vesicle
0.54	GO:0001750	photoreceptor outer segment
0.53	GO:0030425	dendrite
0.53	GO:0005764	lysosome
0.52	GO:0005794	Golgi apparatus
0.48	GO:0030136	clathrin-coated vesicle
0.45	GO:0005798	Golgi-associated vesicle

sp|P51160|PDE6C_HUMAN
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Search

PDE6C

0.55	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

0.61	GO:0007165	signal transduction
0.60	GO:0060042	retina morphogenesis in camera-type eye
0.59	GO:0007601	visual perception
0.56	GO:0003407	neural retina development
0.56	GO:0042462	eye photoreceptor cell development
0.54	GO:0009584	detection of visible light
0.46	GO:0051480	regulation of cytosolic calcium ion concentration
0.45	GO:0045494	photoreceptor cell maintenance
0.44	GO:0046037	GMP metabolic process
0.43	GO:0048598	embryonic morphogenesis

0.79	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.54	GO:0046872	metal ion binding
0.40	GO:0030553	cGMP binding

0.39	GO:0001750	photoreceptor outer segment
0.35	GO:0005886	plasma membrane
0.33	GO:0098588	bounding membrane of organelle
0.30	GO:0044425	membrane part

0.79

GO:0004114

sp|P51161|FABP6_HUMAN
Gastrotropin
Search

FABP6

0.90	Fatty acid-binding protein, liver

0.41	GO:0006869	lipid transport
0.39	GO:0008202	steroid metabolic process
0.38	GO:0019433	triglyceride catabolic process
0.37	GO:0008285	negative regulation of cell proliferation
0.37	GO:0015850	organic hydroxy compound transport
0.36	GO:0015718	monocarboxylic acid transport
0.35	GO:1901615	organic hydroxy compound metabolic process
0.35	GO:0032787	monocarboxylic acid metabolic process

0.86	GO:0032052	bile acid binding
0.72	GO:0008289	lipid binding

0.49	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|P51164|ATP4B_HUMAN
Potassium-transporting ATPase subunit beta
Search

ATP4B

0.80	Potassium-transporting ATPase subunit beta

0.73	GO:0006814	sodium ion transport
0.71	GO:0006813	potassium ion transport
0.40	GO:0032496	response to lipopolysaccharide
0.40	GO:0007155	cell adhesion
0.39	GO:0048923	posterior lateral line neuromast hair cell differentiation
0.39	GO:0010243	response to organonitrogen compound
0.39	GO:0048840	otolith development
0.39	GO:0001964	startle response
0.38	GO:0033577	protein glycosylation in endoplasmic reticulum
0.38	GO:0042472	inner ear morphogenesis

0.42	GO:0008900	potassium:proton exchanging ATPase activity
0.36	GO:0005515	protein binding
0.35	GO:0005391	sodium:potassium-exchanging ATPase activity
0.34	GO:0001671	ATPase activator activity

0.85	GO:0005890	sodium:potassium-exchanging ATPase complex
0.36	GO:0005783	endoplasmic reticulum
0.34	GO:0016324	apical plasma membrane

0.42

EC:3.6.3.10

GO:0008900

sp|P51168|SCNNB_HUMAN
Amiloride-sensitive sodium channel subunit beta
Search

SCNN1B

0.96	Amiloride-sensitive sodium channel subunit beta

0.77	GO:0035725	sodium ion transmembrane transport
0.68	GO:0055078	sodium ion homeostasis
0.67	GO:0050891	multicellular organismal water homeostasis
0.47	GO:0050909	sensory perception of taste
0.39	GO:0050896	response to stimulus
0.38	GO:0007588	excretion
0.38	GO:0090504	epiboly
0.36	GO:0016477	cell migration
0.36	GO:0002028	regulation of sodium ion transport

0.85	GO:0015280	ligand-gated sodium channel activity
0.68	GO:0050699	WW domain binding

0.66	GO:0034706	sodium channel complex
0.63	GO:0009897	external side of plasma membrane
0.63	GO:0070062	extracellular exosome
0.54	GO:0005887	integral component of plasma membrane
0.48	GO:0016324	apical plasma membrane
0.45	GO:0030659	cytoplasmic vesicle membrane
0.40	GO:0005654	nucleoplasm

sp|P51170|SCNNG_HUMAN
Amiloride-sensitive sodium channel subunit gamma
Search

SCNN1G

0.97	Amiloride-sensitive sodium channel subunit gamma

0.76	GO:0035725	sodium ion transmembrane transport
0.64	GO:0055078	sodium ion homeostasis
0.63	GO:0050891	multicellular organismal water homeostasis
0.45	GO:0050909	sensory perception of taste
0.38	GO:0050896	response to stimulus
0.37	GO:0007588	excretion
0.36	GO:0090504	epiboly
0.35	GO:0016477	cell migration

0.85	GO:0015280	ligand-gated sodium channel activity
0.64	GO:0050699	WW domain binding

0.62	GO:0034706	sodium channel complex
0.60	GO:0009897	external side of plasma membrane
0.59	GO:0070062	extracellular exosome
0.52	GO:0005887	integral component of plasma membrane
0.51	GO:0005654	nucleoplasm
0.47	GO:0016324	apical plasma membrane
0.36	GO:0030659	cytoplasmic vesicle membrane
0.33	GO:0060170	ciliary membrane
0.33	GO:0031514	motile cilium

sp|P51172|SCNND_HUMAN
Amiloride-sensitive sodium channel subunit delta
Search

SCNN1D

0.89	Amiloride-sensitive sodium channel subunit delta

0.77	GO:0035725	sodium ion transmembrane transport
0.47	GO:0055078	sodium ion homeostasis
0.46	GO:0050891	multicellular organismal water homeostasis
0.43	GO:0050909	sensory perception of taste
0.37	GO:0050896	response to stimulus
0.33	GO:0023052	signaling
0.33	GO:0007154	cell communication
0.32	GO:0016192	vesicle-mediated transport
0.32	GO:0050789	regulation of biological process

0.85	GO:0015280	ligand-gated sodium channel activity
0.45	GO:0050699	WW domain binding

0.47	GO:0015629	actin cytoskeleton
0.46	GO:0060170	ciliary membrane
0.45	GO:0034706	sodium channel complex
0.45	GO:0016324	apical plasma membrane
0.44	GO:0031514	motile cilium
0.43	GO:0070062	extracellular exosome
0.41	GO:0005887	integral component of plasma membrane
0.36	GO:0005737	cytoplasm

sp|P51178|PLCD1_HUMAN
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Search

PLCD1

0.52	Phosphoinositide phospholipase C

0.72	GO:0016042	lipid catabolic process
0.62	GO:0035556	intracellular signal transduction
0.55	GO:0060716	labyrinthine layer blood vessel development
0.54	GO:0001525	angiogenesis
0.52	GO:0042127	regulation of cell proliferation
0.41	GO:0007340	acrosome reaction
0.38	GO:0046488	phosphatidylinositol metabolic process

0.81	GO:0004435	phosphatidylinositol phospholipase C activity
0.67	GO:0005509	calcium ion binding
0.63	GO:0004871	signal transducer activity
0.58	GO:0032794	GTPase activating protein binding
0.57	GO:0070300	phosphatidic acid binding
0.57	GO:0001786	phosphatidylserine binding
0.56	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding

0.48

GO:0005829

cytosol

0.81	EC:3.1.4.11	GO:0004435
0.81	KEGG:R03435	GO:0004435

sp|P51397|DAP1_HUMAN
Death-associated protein 1
Search

DAP

0.96	death-associated protein 1

0.84	GO:0034198	cellular response to amino acid starvation
0.80	GO:0097190	apoptotic signaling pathway
0.73	GO:0010507	negative regulation of autophagy
0.58	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
0.58	GO:0032088	negative regulation of NF-kappaB transcription factor activity
0.58	GO:0006914	autophagy
0.51	GO:0045892	negative regulation of transcription, DNA-templated
0.36	GO:0006508	proteolysis

0.85	GO:0070513	death domain binding
0.38	GO:0004177	aminopeptidase activity

0.30

GO:0016020

membrane

0.38

EC:3.4.11

GO:0004177

sp|P51398|RT29_HUMAN
28S ribosomal protein S29, mitochondrial
Search

DAP3

0.93	Death associated protein 3

0.77	GO:0006915	apoptotic process
0.42	GO:0001666	response to hypoxia
0.38	GO:0007005	mitochondrion organization
0.37	GO:0032543	mitochondrial translation
0.34	GO:0006415	translational termination
0.34	GO:0006414	translational elongation
0.33	GO:0007165	signal transduction

0.42	GO:0003735	structural constituent of ribosome
0.35	GO:0003723	RNA binding
0.34	GO:0032550	purine ribonucleoside binding
0.34	GO:0019001	guanyl nucleotide binding
0.33	GO:0005515	protein binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003677	DNA binding

0.79	GO:0005761	mitochondrial ribosome
0.70	GO:0015935	small ribosomal subunit
0.49	GO:0005654	nucleoplasm
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0019866	organelle inner membrane

sp|P51449|RORG_HUMAN
Nuclear receptor ROR-gamma
Search

RORC

0.90	RAR-related orphan nuclear receptor variant 2

0.79	GO:0030522	intracellular receptor signaling pathway
0.79	GO:0043401	steroid hormone mediated signaling pathway
0.66	GO:0036315	cellular response to sterol
0.59	GO:0000122	negative regulation of transcription by RNA polymerase II
0.58	GO:0006351	transcription, DNA-templated
0.43	GO:0007623	circadian rhythm
0.42	GO:0072539	T-helper 17 cell differentiation
0.42	GO:0060850	regulation of transcription involved in cell fate commitment
0.41	GO:0042753	positive regulation of circadian rhythm
0.41	GO:0019218	regulation of steroid metabolic process

0.82	GO:0004879	nuclear receptor activity
0.80	GO:0003707	steroid hormone receptor activity
0.69	GO:0008142	oxysterol binding
0.63	GO:0043565	sequence-specific DNA binding
0.63	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.62	GO:0008270	zinc ion binding
0.60	GO:0001012	RNA polymerase II regulatory region DNA binding
0.56	GO:0003690	double-stranded DNA binding
0.42	GO:0001223	transcription coactivator binding
0.39	GO:0001222	transcription corepressor binding

0.61	GO:0005634	nucleus
0.54	GO:0070013	intracellular organelle lumen
0.48	GO:0044446	intracellular organelle part
0.37	GO:0009897	external side of plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P51451|BLK_HUMAN
Tyrosine-protein kinase Blk
Search

BLK

0.58	Tyrosine-protein kinase

0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.59	GO:0050853	B cell receptor signaling pathway
0.55	GO:0050708	regulation of protein secretion
0.55	GO:0090277	positive regulation of peptide hormone secretion
0.53	GO:0051222	positive regulation of protein transport
0.52	GO:0046777	protein autophosphorylation
0.50	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.50	GO:0042127	regulation of cell proliferation
0.48	GO:0030154	cell differentiation
0.48	GO:0045087	innate immune response

0.80	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0005102	receptor binding
0.47	GO:0140031	phosphorylation-dependent protein binding
0.44	GO:0044325	ion channel binding
0.43	GO:0017124	SH3 domain binding
0.42	GO:0032403	protein complex binding

0.48	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.44	GO:0045121	membrane raft
0.43	GO:0048471	perinuclear region of cytoplasm
0.41	GO:0005794	Golgi apparatus
0.40	GO:0005634	nucleus
0.38	GO:0070013	intracellular organelle lumen
0.36	GO:0044446	intracellular organelle part
0.35	GO:0034666	integrin alpha2-beta1 complex
0.34	GO:0042629	mast cell granule
0.34	GO:0001772	immunological synapse

0.80

GO:0004715

sp|P51452|DUS3_HUMAN
Dual specificity protein phosphatase 3
Search

DUSP3

0.95	Dual specificity protein phosphatase 3

0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.59	GO:0050860	negative regulation of T cell receptor signaling pathway
0.58	GO:0046329	negative regulation of JNK cascade
0.57	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.57	GO:0050868	negative regulation of T cell activation
0.57	GO:0000188	inactivation of MAPK activity
0.55	GO:0045931	positive regulation of mitotic cell cycle
0.39	GO:0001701	in utero embryonic development
0.33	GO:0030279	negative regulation of ossification

0.79	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.74	GO:0004725	protein tyrosine phosphatase activity
0.57	GO:0033549	MAP kinase phosphatase activity
0.52	GO:0019901	protein kinase binding

0.56	GO:0001772	immunological synapse
0.49	GO:0005829	cytosol
0.48	GO:0005654	nucleoplasm
0.38	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:3.1.3

GO:0008138

sp|P51460|INSL3_HUMAN
Insulin-like 3
Search

INSL3

0.90	Insulin like 3

0.75	GO:0010469	regulation of receptor activity
0.51	GO:0090303	positive regulation of wound healing
0.50	GO:0010634	positive regulation of epithelial cell migration
0.45	GO:0007276	gamete generation
0.45	GO:0008584	male gonad development
0.44	GO:2000018	regulation of male gonad development
0.44	GO:0043950	positive regulation of cAMP-mediated signaling
0.43	GO:0007186	G-protein coupled receptor signaling pathway
0.42	GO:0071695	anatomical structure maturation
0.42	GO:0048469	cell maturation

0.78	GO:0005179	hormone activity
0.50	GO:0002020	protease binding
0.43	GO:0005158	insulin receptor binding
0.41	GO:0001664	G-protein coupled receptor binding

0.66	GO:0005576	extracellular region
0.41	GO:0048471	perinuclear region of cytoplasm

sp|P51504|ZNF80_HUMAN
Zinc finger protein 80
Search

ZNF80

0.84	Zinc finger protein 80

0.53	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:1903506	regulation of nucleic acid-templated transcription
0.53	GO:0010468	regulation of gene expression
0.38	GO:0097659	nucleic acid-templated transcription
0.37	GO:0010467	gene expression
0.37	GO:0034645	cellular macromolecule biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.50	GO:0046872	metal ion binding
0.43	GO:0003700	DNA binding transcription factor activity
0.38	GO:0042802	identical protein binding

0.43	GO:0005622	intracellular
0.38	GO:0043227	membrane-bounded organelle

sp|P51508|ZNF81_HUMAN
Zinc finger protein 81
Search

ZNF81

0.83	Zinc finger protein 41

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.47	GO:0006366	transcription by RNA polymerase II
0.46	GO:1902680	positive regulation of RNA biosynthetic process
0.42	GO:1902679	negative regulation of RNA biosynthetic process
0.37	GO:0051607	defense response to virus

0.52	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.49	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.46	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.37	GO:0005515	protein binding

0.45	GO:0031981	nuclear lumen
0.44	GO:0045111	intermediate filament cytoskeleton
0.41	GO:0005829	cytosol

sp|P51511|MMP15_HUMAN
Matrix metalloproteinase-15
Search

MMP15

0.73	Membrane-type matrix metalloproteinase

0.60	GO:0006508	proteolysis
0.59	GO:0035987	endodermal cell differentiation
0.43	GO:0032355	response to estradiol
0.42	GO:0030574	collagen catabolic process
0.40	GO:0035988	chondrocyte proliferation
0.39	GO:0097094	craniofacial suture morphogenesis
0.39	GO:0001958	endochondral ossification
0.39	GO:0048701	embryonic cranial skeleton morphogenesis
0.37	GO:0022617	extracellular matrix disassembly
0.37	GO:0051604	protein maturation

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.40	GO:0070006	metalloaminopeptidase activity
0.36	GO:0008047	enzyme activator activity
0.34	GO:0005515	protein binding
0.32	GO:0004518	nuclease activity

0.74	GO:0031012	extracellular matrix
0.65	GO:0005887	integral component of plasma membrane

0.70

GO:0004222

sp|P51512|MMP16_HUMAN
Matrix metalloproteinase-16
Search

MMP16

0.73	Membrane type-matrix metalloproteinase

0.61	GO:0006508	proteolysis
0.56	GO:0035988	chondrocyte proliferation
0.56	GO:0097094	craniofacial suture morphogenesis
0.55	GO:0001958	endochondral ossification
0.55	GO:0030574	collagen catabolic process
0.54	GO:0048701	embryonic cranial skeleton morphogenesis
0.49	GO:0051604	protein maturation
0.35	GO:1990834	response to odorant
0.35	GO:0022617	extracellular matrix disassembly
0.34	GO:0044331	cell-cell adhesion mediated by cadherin

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.51	GO:0070006	metalloaminopeptidase activity
0.34	GO:0008047	enzyme activator activity
0.34	GO:0045296	cadherin binding

0.74	GO:0031012	extracellular matrix
0.47	GO:0005887	integral component of plasma membrane
0.35	GO:0005796	Golgi lumen
0.34	GO:0009986	cell surface
0.34	GO:0032588	trans-Golgi network membrane

0.70

GO:0004222

sp|P51513|NOVA1_HUMAN
RNA-binding protein Nova-1
Search

NOVA1

0.93	NOVA alternative splicing regulator 1

0.75	GO:0000398	mRNA splicing, via spliceosome
0.50	GO:0051252	regulation of RNA metabolic process

0.63

GO:0003729

mRNA binding

0.63

GO:0005730

nucleolus

sp|P51522|ZNF83_HUMAN
Zinc finger protein 83
Search

0.71	Zinc finger protein 83

0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:1903506	regulation of nucleic acid-templated transcription
0.53	GO:0010468	regulation of gene expression
0.42	GO:0097659	nucleic acid-templated transcription
0.41	GO:0010467	gene expression
0.40	GO:0034645	cellular macromolecule biosynthetic process

0.51	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.44	GO:0003700	DNA binding transcription factor activity
0.30	GO:0005515	protein binding

0.44

GO:0005634

nucleus

sp|P51523|ZNF84_HUMAN
Zinc finger protein 84
Search

0.53	Zinc finger domain-containing protein (Fragment)

0.54	GO:1903506	regulation of nucleic acid-templated transcription
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:0010468	regulation of gene expression
0.42	GO:1902679	negative regulation of RNA biosynthetic process
0.41	GO:0071157	negative regulation of cell cycle arrest
0.39	GO:0030335	positive regulation of cell migration
0.39	GO:0008285	negative regulation of cell proliferation
0.39	GO:0008284	positive regulation of cell proliferation
0.39	GO:0043065	positive regulation of apoptotic process
0.39	GO:0045597	positive regulation of cell differentiation

0.51	GO:0003676	nucleic acid binding
0.50	GO:0046872	metal ion binding
0.39	GO:0003700	DNA binding transcription factor activity

0.43	GO:0005622	intracellular
0.36	GO:0043227	membrane-bounded organelle
0.36	GO:0043228	non-membrane-bounded organelle

sp|P51530|DNA2_HUMAN
DNA replication ATP-dependent helicase/nuclease DNA2
Search

DNA2

0.89	DNA replication helicase/nuclease 2

0.82	GO:0033567	DNA replication, Okazaki fragment processing
0.63	GO:1902990	mitotic telomere maintenance via semi-conservative replication
0.62	GO:0006264	mitochondrial DNA replication
0.62	GO:0000729	DNA double-strand break processing
0.61	GO:0043504	mitochondrial DNA repair
0.61	GO:0000076	DNA replication checkpoint
0.60	GO:0045740	positive regulation of DNA replication
0.53	GO:0006284	base-excision repair
0.53	GO:0006401	RNA catabolic process
0.52	GO:0032392	DNA geometric change

0.83	GO:0043142	single-stranded DNA-dependent ATPase activity
0.82	GO:0017108	5'-flap endonuclease activity
0.63	GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base
0.60	GO:0004386	helicase activity
0.44	GO:0003677	DNA binding
0.39	GO:0051539	4 iron, 4 sulfur cluster binding
0.37	GO:0046872	metal ion binding
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding

0.60	GO:0005760	gamma DNA polymerase complex
0.58	GO:0042645	mitochondrial nucleoid
0.56	GO:0000784	nuclear chromosome, telomeric region
0.35	GO:0005654	nucleoplasm
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0019866	organelle inner membrane
0.33	GO:0035861	site of double-strand break
0.33	GO:0043596	nuclear replication fork
0.30	GO:0031224	intrinsic component of membrane

0.63

EC:3.1.25

GO:0016890

sp|P51531|SMCA2_HUMAN
Probable global transcription activator SNF2L2
Search

SMARCA2

0.85	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

0.78	GO:0006338	chromatin remodeling
0.62	GO:0030308	negative regulation of cell growth
0.59	GO:0008285	negative regulation of cell proliferation
0.57	GO:0006366	transcription by RNA polymerase II
0.57	GO:0045944	positive regulation of transcription by RNA polymerase II
0.55	GO:0045892	negative regulation of transcription, DNA-templated
0.43	GO:0035887	aortic smooth muscle cell differentiation
0.40	GO:0007286	spermatid development
0.39	GO:1902661	positive regulation of glucose mediated signaling pathway
0.38	GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

0.79	GO:0042393	histone binding
0.64	GO:0001105	RNA polymerase II transcription coactivator activity
0.61	GO:0016887	ATPase activity
0.58	GO:0044212	transcription regulatory region DNA binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0003682	chromatin binding
0.38	GO:0030957	Tat protein binding
0.38	GO:0070182	DNA polymerase binding

0.82	GO:0016514	SWI/SNF complex
0.58	GO:0045111	intermediate filament cytoskeleton
0.53	GO:0005654	nucleoplasm
0.43	GO:0071564	npBAF complex
0.40	GO:0071565	nBAF complex
0.36	GO:0005730	nucleolus

0.61

GO:0016887

sp|P51532|SMCA4_HUMAN
Transcription activator BRG1
Search

SMARCA4

0.76	Transcription activator BRG1

0.81	GO:0043044	ATP-dependent chromatin remodeling
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.42	GO:1902661	positive regulation of glucose mediated signaling pathway
0.41	GO:0038111	interleukin-7-mediated signaling pathway
0.41	GO:0060766	negative regulation of androgen receptor signaling pathway
0.41	GO:1904837	beta-catenin-TCF complex assembly
0.40	GO:0051851	modification by host of symbiont morphology or physiology
0.40	GO:0031498	chromatin disassembly

0.79	GO:0042393	histone binding
0.61	GO:0016887	ATPase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0030957	Tat protein binding
0.41	GO:0070182	DNA polymerase binding
0.41	GO:0050681	androgen receptor binding
0.40	GO:0001164	RNA polymerase I CORE element sequence-specific DNA binding

0.82	GO:0016514	SWI/SNF complex
0.40	GO:0071564	npBAF complex
0.40	GO:0071565	nBAF complex
0.39	GO:0042721	mitochondrial inner membrane protein insertion complex
0.38	GO:0005730	nucleolus
0.37	GO:0005615	extracellular space
0.37	GO:0005654	nucleoplasm
0.33	GO:0005726	perichromatin fibrils
0.33	GO:0005719	nuclear euchromatin
0.33	GO:0000792	heterochromatin

0.61

GO:0016887

sp|P51553|IDH3G_HUMAN
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
Search

IDH3G

0.65	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

0.69	GO:0006099	tricarboxylic acid cycle
0.39	GO:0006102	isocitrate metabolic process
0.35	GO:0006734	NADH metabolic process
0.35	GO:0045926	negative regulation of growth
0.35	GO:0006103	2-oxoglutarate metabolic process
0.33	GO:0005975	carbohydrate metabolic process

0.83	GO:0004449	isocitrate dehydrogenase (NAD+) activity
0.67	GO:0051287	NAD binding
0.63	GO:0000287	magnesium ion binding
0.35	GO:0030554	adenyl nucleotide binding
0.35	GO:0032555	purine ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding

0.59	GO:0005739	mitochondrion
0.47	GO:0005730	nucleolus
0.45	GO:0005654	nucleoplasm
0.35	GO:0045242	isocitrate dehydrogenase complex (NAD+)

0.83

EC:1.1.1.41

GO:0004449

sp|P51570|GALK1_HUMAN
Galactokinase
Search

GALK1

0.51	Epididymis secretory protein Li 19

0.76	GO:0006012	galactose metabolic process
0.74	GO:0046835	carbohydrate phosphorylation
0.61	GO:0061622	glycolytic process through glucose-1-phosphate
0.56	GO:0019402	galactitol metabolic process
0.53	GO:0019320	hexose catabolic process
0.34	GO:0051260	protein homooligomerization
0.33	GO:0006364	rRNA processing

0.81	GO:0004335	galactokinase activity
0.75	GO:0005534	galactose binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding

0.48	GO:0005737	cytoplasm
0.37	GO:0070062	extracellular exosome
0.33	GO:0005730	nucleolus
0.30	GO:0031224	intrinsic component of membrane

0.81	EC:2.7.1.6	GO:0004335
0.81	KEGG:R01092	GO:0004335

sp|P51571|SSRD_HUMAN
Translocon-associated protein subunit delta
Search

SSR4

0.92	Translocon-associated protein subunit delta

0.42

GO:0071391

cellular response to estrogen stimulus

0.68	GO:0005783	endoplasmic reticulum
0.41	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.40	GO:0031984	organelle subcompartment
0.38	GO:0070062	extracellular exosome
0.37	GO:0098588	bounding membrane of organelle
0.36	GO:0098796	membrane protein complex
0.30	GO:0031224	intrinsic component of membrane

sp|P51572|BAP31_HUMAN
B-cell receptor-associated protein 31
Search

BCAP31

0.96	B-cell receptor-associated protein 31

0.69	GO:0006886	intracellular protein transport
0.60	GO:0070973	protein localization to endoplasmic reticulum exit site
0.57	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol
0.57	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process
0.55	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
0.55	GO:0051561	positive regulation of mitochondrial calcium ion concentration
0.54	GO:0006888	ER to Golgi vesicle-mediated transport
0.54	GO:0035584	calcium-mediated signaling using intracellular calcium source
0.53	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
0.52	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

0.55	GO:0042288	MHC class I protein binding
0.49	GO:0032403	protein complex binding
0.35	GO:0044325	ion channel binding
0.33	GO:0008271	secondary active sulfate transmembrane transporter activity
0.33	GO:0042393	histone binding
0.33	GO:0003682	chromatin binding

0.70	GO:0005783	endoplasmic reticulum
0.51	GO:0005811	lipid droplet
0.50	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.50	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0031984	organelle subcompartment
0.48	GO:0044431	Golgi apparatus part
0.48	GO:0098588	bounding membrane of organelle
0.45	GO:0005887	integral component of plasma membrane
0.43	GO:0098796	membrane protein complex
0.43	GO:0005739	mitochondrion

sp|P51575|P2RX1_HUMAN
P2X purinoceptor 1
Search

0.25	Purinergic receptor P2X, ligand-gated ion channel, 1 (Fragment)

0.85	GO:0033198	response to ATP
0.84	GO:0035590	purinergic nucleotide receptor signaling pathway
0.80	GO:0060079	excitatory postsynaptic potential
0.61	GO:0098655	cation transmembrane transport

0.85	GO:0004931	extracellularly ATP-gated cation channel activity
0.85	GO:0016502	nucleotide receptor activity
0.84	GO:0035586	purinergic receptor activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.78	GO:0098794	postsynapse
0.67	GO:0005887	integral component of plasma membrane

sp|P51580|TPMT_HUMAN
Thiopurine S-methyltransferase
Search

TPMT

0.67	Thiopurine S-methyltransferase

0.63	GO:0032259	methylation
0.35	GO:0033574	response to testosterone
0.35	GO:0010038	response to metal ion
0.32	GO:0046483	heterocycle metabolic process
0.32	GO:1901360	organic cyclic compound metabolic process
0.32	GO:0006725	cellular aromatic compound metabolic process
0.32	GO:0006807	nitrogen compound metabolic process
0.30	GO:0044238	primary metabolic process

0.85	GO:0008119	thiopurine S-methyltransferase activity
0.32	GO:0016874	ligase activity

0.37	GO:0005737	cytoplasm
0.37	GO:0070062	extracellular exosome

0.85

EC:2.1.1.67

GO:0008119

sp|P51582|P2RY4_HUMAN
P2Y purinoceptor 4
Search

P2RY4

0.86	Neuropeptide FF receptor 2

0.85	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
0.80	GO:0030321	transepithelial chloride transport
0.62	GO:0070257	positive regulation of mucus secretion
0.60	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
0.58	GO:0071380	cellular response to prostaglandin E stimulus
0.57	GO:0097746	regulation of blood vessel diameter
0.37	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.35	GO:0060406	positive regulation of penile erection
0.35	GO:0032308	positive regulation of prostaglandin secretion
0.35	GO:0071415	cellular response to purine-containing compound

0.85	GO:0045028	G-protein coupled purinergic nucleotide receptor activity
0.61	GO:0045030	UTP-activated nucleotide receptor activity
0.36	GO:0019103	pyrimidine nucleotide binding
0.35	GO:0031686	A1 adenosine receptor binding
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0016787	hydrolase activity

0.40	GO:0016323	basolateral plasma membrane
0.40	GO:0016324	apical plasma membrane
0.35	GO:0005887	integral component of plasma membrane
0.34	GO:0005769	early endosome
0.34	GO:0005764	lysosome
0.32	GO:0005739	mitochondrion

0.32

GO:0016787

sp|P51587|BRCA2_HUMAN
Breast cancer type 2 susceptibility protein
Search

BRCA2

0.65	BRCA2, DNA repair associated

0.82	GO:0033600	negative regulation of mammary gland epithelial cell proliferation
0.81	GO:0070200	establishment of protein localization to telomere
0.80	GO:0001833	inner cell mass cell proliferation
0.79	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
0.79	GO:0010225	response to UV-C
0.79	GO:0001556	oocyte maturation
0.78	GO:0007141	male meiosis I
0.78	GO:0010165	response to X-ray
0.78	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.77	GO:0000724	double-strand break repair via homologous recombination

0.78	GO:0010485	H4 histone acetyltransferase activity
0.77	GO:0010484	H3 histone acetyltransferase activity
0.75	GO:0002020	protease binding
0.74	GO:0043015	gamma-tubulin binding
0.74	GO:0008022	protein C-terminus binding
0.67	GO:0003697	single-stranded DNA binding
0.66	GO:0042802	identical protein binding

0.84	GO:0033593	BRCA2-MAGE-D1 complex
0.78	GO:0000800	lateral element
0.72	GO:0000784	nuclear chromosome, telomeric region
0.72	GO:0030141	secretory granule
0.70	GO:0005813	centrosome
0.63	GO:0005654	nucleoplasm
0.62	GO:0005829	cytosol

sp|P51589|CP2J2_HUMAN
Cytochrome P450 2J2
Search

CYP2J2

0.93	Cytochrome P450 family 2 subfamily J member 2

0.55	GO:0043651	linoleic acid metabolic process
0.54	GO:0019373	epoxygenase P450 pathway
0.53	GO:0055114	oxidation-reduction process
0.41	GO:0032966	negative regulation of collagen biosynthetic process
0.41	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway
0.40	GO:1903532	positive regulation of secretion by cell
0.40	GO:1904467	regulation of tumor necrosis factor secretion
0.39	GO:0032760	positive regulation of tumor necrosis factor production
0.39	GO:0007565	female pregnancy
0.39	GO:0001523	retinoid metabolic process

0.79	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.57	GO:0008404	arachidonic acid 14,15-epoxygenase activity
0.57	GO:0008405	arachidonic acid 11,12-epoxygenase activity
0.56	GO:0071614	linoleic acid epoxygenase activity
0.39	GO:0003958	NADPH-hemoprotein reductase activity
0.36	GO:0008395	steroid hydroxylase activity

0.41	GO:0005783	endoplasmic reticulum
0.39	GO:0070062	extracellular exosome
0.38	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.37	GO:0031984	organelle subcompartment
0.36	GO:0031090	organelle membrane
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:1.14.14

GO:0016712

sp|P51606|RENBP_HUMAN
N-acylglucosamine 2-epimerase
Search

RENBP

0.60	N-acylglucosamine 2-epimerase

0.54	GO:0006044	N-acetylglucosamine metabolic process
0.46	GO:0010951	negative regulation of endopeptidase activity
0.41	GO:0019262	N-acetylneuraminate catabolic process
0.39	GO:0006050	mannosamine metabolic process
0.36	GO:0008217	regulation of blood pressure
0.35	GO:0006048	UDP-N-acetylglucosamine biosynthetic process
0.33	GO:0006468	protein phosphorylation
0.33	GO:0033198	response to ATP
0.33	GO:0035590	purinergic nucleotide receptor signaling pathway
0.33	GO:0060079	excitatory postsynaptic potential

0.63	GO:0050121	N-acylglucosamine 2-epimerase activity
0.46	GO:0004866	endopeptidase inhibitor activity
0.38	GO:0042803	protein homodimerization activity
0.36	GO:0008080	N-acetyltransferase activity
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0004672	protein kinase activity
0.33	GO:0004931	extracellularly ATP-gated cation channel activity
0.33	GO:0016502	nucleotide receptor activity

0.37	GO:0070062	extracellular exosome
0.37	GO:0071339	MLL1 complex
0.37	GO:0048188	Set1C/COMPASS complex
0.34	GO:0005829	cytosol
0.33	GO:0098794	postsynapse
0.32	GO:0005887	integral component of plasma membrane

0.63

EC:5.1.3.8

GO:0050121

sp|P51608|MECP2_HUMAN
Methyl-CpG-binding protein 2
Search

MECP2

0.96	Methyl CpG binding protein 2 transcript variant 1

0.78	GO:0000122	negative regulation of transcription by RNA polymerase II
0.58	GO:1905643	positive regulation of DNA methylation
0.58	GO:0050432	catecholamine secretion
0.58	GO:0090063	positive regulation of microtubule nucleation
0.57	GO:0019230	proprioception
0.57	GO:1900114	positive regulation of histone H3-K9 trimethylation
0.56	GO:0008211	glucocorticoid metabolic process
0.56	GO:0051151	negative regulation of smooth muscle cell differentiation
0.56	GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure
0.56	GO:0002087	regulation of respiratory gaseous exchange by neurological system process

0.86	GO:0010385	double-stranded methylated DNA binding
0.56	GO:0008327	methyl-CpG binding
0.56	GO:0035197	siRNA binding
0.54	GO:0047485	protein N-terminus binding
0.54	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.50	GO:0003682	chromatin binding
0.50	GO:0019904	protein domain specific binding
0.50	GO:0003729	mRNA binding
0.49	GO:0008134	transcription factor binding
0.35	GO:0045322	unmethylated CpG binding

0.61	GO:0005634	nucleus
0.54	GO:0000792	heterochromatin
0.53	GO:0000930	gamma-tubulin complex
0.51	GO:0098794	postsynapse
0.51	GO:0005813	centrosome
0.47	GO:0005829	cytosol
0.43	GO:0005739	mitochondrion
0.36	GO:0005615	extracellular space
0.35	GO:0043233	organelle lumen
0.35	GO:0034708	methyltransferase complex

0.33

GO:0008080

sp|P51610|HCFC1_HUMAN
Host cell factor 1
Search

HCFC1

0.84	Host cell factor

0.57	GO:0019045	latent virus replication
0.57	GO:0043982	histone H4-K8 acetylation
0.57	GO:0043981	histone H4-K5 acetylation
0.56	GO:0043984	histone H4-K16 acetylation
0.53	GO:0050821	protein stabilization
0.50	GO:0006366	transcription by RNA polymerase II
0.50	GO:0045944	positive regulation of transcription by RNA polymerase II
0.47	GO:0043254	regulation of protein complex assembly
0.42	GO:0000122	negative regulation of transcription by RNA polymerase II
0.40	GO:0071407	cellular response to organic cyclic compound

0.58	GO:0043996	histone acetyltransferase activity (H4-K8 specific)
0.58	GO:0046972	histone acetyltransferase activity (H4-K16 specific)
0.58	GO:0043995	histone acetyltransferase activity (H4-K5 specific)
0.55	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
0.54	GO:0033613	activating transcription factor binding
0.52	GO:0003713	transcription coactivator activity
0.52	GO:0045296	cadherin binding
0.52	GO:0030674	protein binding, bridging
0.51	GO:0003682	chromatin binding
0.49	GO:0042802	identical protein binding

0.82	GO:0071339	MLL1 complex
0.81	GO:0048188	Set1C/COMPASS complex
0.54	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
0.53	GO:0043025	neuronal cell body
0.51	GO:0070461	SAGA-type complex
0.40	GO:0030425	dendrite
0.40	GO:0030424	axon
0.39	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|P51617|IRAK1_HUMAN
Interleukin-1 receptor-associated kinase 1
Search

IRAK1

0.97	Interleukin-1 receptor-associated kinase I transcript variant 1

0.84	GO:0070498	interleukin-1-mediated signaling pathway
0.63	GO:0006468	protein phosphorylation
0.60	GO:0060337	type I interferon signaling pathway
0.59	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.58	GO:0007250	activation of NF-kappaB-inducing kinase activity
0.58	GO:0034134	toll-like receptor 2 signaling pathway
0.58	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.58	GO:0032481	positive regulation of type I interferon production
0.57	GO:0031663	lipopolysaccharide-mediated signaling pathway
0.57	GO:0032088	negative regulation of NF-kappaB transcription factor activity

0.69	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0042803	protein homodimerization activity
0.52	GO:0046982	protein heterodimerization activity
0.39	GO:0031072	heat shock protein binding
0.39	GO:0005149	interleukin-1 receptor binding
0.39	GO:0004842	ubiquitin-protein transferase activity

0.49	GO:0005829	cytosol
0.47	GO:0005634	nucleus
0.42	GO:0005811	lipid droplet
0.38	GO:0045323	interleukin-1 receptor complex
0.36	GO:0010008	endosome membrane
0.34	GO:0034708	methyltransferase complex
0.33	GO:0070013	intracellular organelle lumen

0.69	EC:2.7.11	GO:0004674
0.39	KEGG:R03876	GO:0004842

sp|P51636|CAV2_HUMAN
Caveolin-2
Search

CAV2

0.81

Caveolin

0.85	GO:0070836	caveola assembly
0.66	GO:0060161	positive regulation of dopamine receptor signaling pathway
0.65	GO:0014902	myotube differentiation
0.64	GO:0001937	negative regulation of endothelial cell proliferation
0.64	GO:0055002	striated muscle cell development
0.63	GO:0014706	striated muscle tissue development
0.61	GO:0060538	skeletal muscle organ development
0.61	GO:0007029	endoplasmic reticulum organization
0.61	GO:0006906	vesicle fusion
0.60	GO:0044789	modulation by host of viral release from host cell

0.62	GO:0032947	protein complex scaffold activity
0.60	GO:0031748	D1 dopamine receptor binding
0.57	GO:0097110	scaffold protein binding
0.54	GO:0030674	protein binding, bridging
0.53	GO:0019901	protein kinase binding
0.52	GO:0044325	ion channel binding
0.52	GO:0042803	protein homodimerization activity
0.51	GO:0046982	protein heterodimerization activity
0.45	GO:0071253	connexin binding
0.44	GO:0043014	alpha-tubulin binding

0.84	GO:0005901	caveola
0.73	GO:0000139	Golgi membrane
0.59	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.59	GO:0048471	perinuclear region of cytoplasm
0.58	GO:0002080	acrosomal membrane
0.55	GO:0005925	focal adhesion
0.52	GO:0030133	transport vesicle
0.47	GO:0005887	integral component of plasma membrane
0.46	GO:0043234	protein complex
0.45	GO:0005634	nucleus

sp|P51648|AL3A2_HUMAN
Fatty aldehyde dehydrogenase
Search

ALDH3A2

0.43	Fatty aldehyde dehydrogenase

0.67	GO:0006081	cellular aldehyde metabolic process
0.57	GO:0033306	phytol metabolic process
0.53	GO:0007422	peripheral nervous system development
0.52	GO:0055114	oxidation-reduction process
0.52	GO:0008544	epidermis development
0.50	GO:0007417	central nervous system development
0.38	GO:0006714	sesquiterpenoid metabolic process
0.35	GO:0030148	sphingolipid biosynthetic process
0.34	GO:0009062	fatty acid catabolic process
0.34	GO:0030258	lipid modification

0.77	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
0.54	GO:0046577	long-chain-alcohol oxidase activity
0.53	GO:0004029	aldehyde dehydrogenase (NAD) activity
0.39	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity
0.38	GO:0008106	alcohol dehydrogenase (NADP+) activity

0.46	GO:0005783	endoplasmic reticulum
0.41	GO:0031966	mitochondrial membrane
0.41	GO:0019866	organelle inner membrane
0.38	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.38	GO:0042579	microbody
0.37	GO:0031984	organelle subcompartment
0.37	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome
0.35	GO:0098805	whole membrane
0.35	GO:0098588	bounding membrane of organelle

0.77

EC:1.2.1.5

GO:0004030

sp|P51649|SSDH_HUMAN
Succinate-semialdehyde dehydrogenase, mitochondrial
Search

ALDH5A1

0.47	Succinate-semialdehyde dehydrogenase

0.78	GO:0009450	gamma-aminobutyric acid catabolic process
0.56	GO:0051289	protein homotetramerization
0.55	GO:0006681	galactosylceramide metabolic process
0.55	GO:0006678	glucosylceramide metabolic process
0.54	GO:0006105	succinate metabolic process
0.53	GO:0007417	central nervous system development
0.53	GO:0055114	oxidation-reduction process
0.51	GO:0046459	short-chain fatty acid metabolic process
0.51	GO:0009791	post-embryonic development
0.51	GO:0006083	acetate metabolic process

0.77	GO:0009013	succinate-semialdehyde dehydrogenase [NAD(P)+] activity
0.59	GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity
0.41	GO:0051287	NAD binding
0.34	GO:0042803	protein homodimerization activity
0.34	GO:0047949	glutarate-semialdehyde dehydrogenase activity
0.34	GO:0005388	calcium-transporting ATPase activity
0.34	GO:0031406	carboxylic acid binding
0.34	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
0.32	GO:0005524	ATP binding

0.46	GO:0005739	mitochondrion
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.77

EC:1.2.1.16

GO:0009013

sp|P51654|GPC3_HUMAN
Glypican-3
Search

GPC3

0.96	Intestinal protein OCI-5 (Fragment)

0.70	GO:0009966	regulation of signal transduction
0.61	GO:0061209	cell proliferation involved in mesonephros development
0.60	GO:0072180	mesonephric duct morphogenesis
0.60	GO:0072203	cell proliferation involved in metanephros development
0.59	GO:0010463	mesenchymal cell proliferation
0.58	GO:0035116	embryonic hindlimb morphogenesis
0.58	GO:0030282	bone mineralization
0.58	GO:0030316	osteoclast differentiation
0.58	GO:0046326	positive regulation of glucose import
0.58	GO:0060976	coronary vasculature development

0.83	GO:0043395	heparan sulfate proteoglycan binding
0.63	GO:0060422	peptidyl-dipeptidase inhibitor activity
0.32	GO:0003735	structural constituent of ribosome

0.83	GO:0046658	anchored component of plasma membrane
0.76	GO:0005578	proteinaceous extracellular matrix
0.54	GO:0005764	lysosome
0.39	GO:0005796	Golgi lumen
0.39	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.36	GO:0005775	vacuolar lumen
0.36	GO:0005887	integral component of plasma membrane
0.36	GO:0005788	endoplasmic reticulum lumen
0.32	GO:0005840	ribosome

sp|P51659|DHB4_HUMAN
Peroxisomal multifunctional enzyme type 2
Search

HSD17B4

0.85	Peroxisomal multifunctional enzyme type 2

0.58	GO:0036111	very long-chain fatty-acyl-CoA metabolic process
0.57	GO:0036112	medium-chain fatty-acyl-CoA metabolic process
0.56	GO:0008209	androgen metabolic process
0.55	GO:0008210	estrogen metabolic process
0.55	GO:0060009	Sertoli cell development
0.52	GO:0000038	very long-chain fatty acid metabolic process
0.52	GO:0055114	oxidation-reduction process
0.50	GO:0009062	fatty acid catabolic process
0.48	GO:0030258	lipid modification
0.43	GO:0048568	embryonic organ development

0.59	GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity
0.58	GO:0016508	long-chain-enoyl-CoA hydratase activity
0.50	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
0.49	GO:0042803	protein homodimerization activity
0.48	GO:0005102	receptor binding
0.42	GO:0033989	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
0.36	GO:0030283	testosterone dehydrogenase [NAD(P)] activity
0.35	GO:0018812	3-hydroxyacyl-CoA dehydratase activity
0.35	GO:0004303	estradiol 17-beta-dehydrogenase activity
0.35	GO:0016853	isomerase activity

0.51	GO:0005777	peroxisome
0.43	GO:0005739	mitochondrion
0.36	GO:0031903	microbody membrane
0.35	GO:0031907	microbody lumen

0.58

EC:4.2.1.74

GO:0016508

sp|P51665|PSMD7_HUMAN
26S proteasome non-ATPase regulatory subunit 7
Search

PSMD7

0.70	Eukaryotic translation initiation factor 3 subunit F

0.46	GO:0021551	central nervous system morphogenesis
0.45	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.44	GO:1904888	cranial skeletal system development
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.35	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:1902036	regulation of hematopoietic stem cell differentiation
0.35	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia

0.49	GO:0042803	protein homodimerization activity
0.33	GO:0003743	translation initiation factor activity

0.81	GO:0005838	proteasome regulatory particle
0.48	GO:0005654	nucleoplasm
0.36	GO:0070062	extracellular exosome
0.35	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0034774	secretory granule lumen
0.34	GO:0005829	cytosol
0.34	GO:0030425	dendrite
0.30	GO:0016020	membrane

sp|P51668|UB2D1_HUMAN
Ubiquitin-conjugating enzyme E2 D1
Search

UBE2D1

0.95	Ubiquitin conjugating enzyme E2 D1

0.59	GO:0070936	protein K48-linked ubiquitination
0.56	GO:1902916	positive regulation of protein polyubiquitination
0.49	GO:0035519	protein K29-linked ubiquitination
0.49	GO:0044314	protein K27-linked ubiquitination
0.49	GO:0085020	protein K6-linked ubiquitination
0.48	GO:0006511	ubiquitin-dependent protein catabolic process
0.48	GO:0070979	protein K11-linked ubiquitination
0.47	GO:0070534	protein K63-linked ubiquitination
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0035666	TRIF-dependent toll-like receptor signaling pathway

0.60	GO:0061631	ubiquitin conjugating enzyme activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005515	protein binding
0.33	GO:0016874	ligase activity

0.50	GO:0000151	ubiquitin ligase complex
0.43	GO:0043234	protein complex
0.38	GO:0005737	cytoplasm
0.33	GO:0005654	nucleoplasm

0.33

EC:6

GO:0016874

sp|P51671|CCL11_HUMAN
Eotaxin
Search

0.75	C-C motif chemokine

0.82	GO:0060326	cell chemotaxis
0.74	GO:0006955	immune response
0.73	GO:0010469	regulation of receptor activity
0.68	GO:0097529	myeloid leukocyte migration
0.60	GO:0030334	regulation of cell migration
0.59	GO:0071674	mononuclear cell migration
0.58	GO:0071347	cellular response to interleukin-1
0.57	GO:0071356	cellular response to tumor necrosis factor
0.57	GO:0007010	cytoskeleton organization
0.57	GO:0006954	inflammatory response

0.84	GO:0008009	chemokine activity
0.65	GO:0048020	CCR chemokine receptor binding
0.46	GO:0046983	protein dimerization activity
0.44	GO:0016004	phospholipase activator activity
0.39	GO:0008201	heparin binding
0.39	GO:0004672	protein kinase activity
0.34	GO:0005153	interleukin-8 receptor binding

0.70	GO:0005615	extracellular space
0.36	GO:0005622	intracellular

sp|P51674|GPM6A_HUMAN
Neuronal membrane glycoprotein M6-a
Search

GPM6A

0.94	Proteolipid protein DM beta

0.54	GO:0001764	neuron migration
0.53	GO:0048863	stem cell differentiation
0.53	GO:0003407	neural retina development
0.52	GO:0031175	neuron projection development
0.50	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.45	GO:0051489	regulation of filopodium assembly
0.41	GO:0120034	positive regulation of plasma membrane bounded cell projection assembly
0.41	GO:0007416	synapse assembly
0.38	GO:0070588	calcium ion transmembrane transport

0.38	GO:0005262	calcium channel activity
0.34	GO:0005515	protein binding

0.54	GO:0044295	axonal growth cone
0.41	GO:0030175	filopodium
0.40	GO:0043025	neuronal cell body
0.40	GO:0043197	dendritic spine
0.36	GO:0070062	extracellular exosome
0.35	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P51677|CCR3_HUMAN
C-C chemokine receptor type 3
Search

CCR3

0.97	C-C motif chemokine receptor 3

0.83	GO:0070098	chemokine-mediated signaling pathway
0.79	GO:0006954	inflammatory response
0.70	GO:0006935	chemotaxis
0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.65	GO:0006955	immune response
0.63	GO:0090026	positive regulation of monocyte chemotaxis
0.56	GO:0051094	positive regulation of developmental process
0.55	GO:0051240	positive regulation of multicellular organismal process
0.55	GO:2000026	regulation of multicellular organismal development
0.53	GO:0001938	positive regulation of endothelial cell proliferation

0.85	GO:0016493	C-C chemokine receptor activity
0.64	GO:0019957	C-C chemokine binding
0.47	GO:0004435	phosphatidylinositol phospholipase C activity
0.35	GO:0003779	actin binding

0.48	GO:0009897	external side of plasma membrane
0.36	GO:0005768	endosome
0.36	GO:0043025	neuronal cell body
0.35	GO:0005887	integral component of plasma membrane
0.34	GO:0005615	extracellular space

0.47	EC:3.1.4.11	GO:0004435
0.47	KEGG:R03435	GO:0004435

sp|P51679|CCR4_HUMAN
C-C chemokine receptor type 4
Search

CCR4

0.97	C-C motif chemokine receptor 4

0.84	GO:0070098	chemokine-mediated signaling pathway
0.78	GO:0006954	inflammatory response
0.71	GO:0006955	immune response
0.71	GO:0006935	chemotaxis
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.59	GO:0002507	tolerance induction
0.56	GO:0001764	neuron migration
0.55	GO:0050921	positive regulation of chemotaxis
0.55	GO:0071677	positive regulation of mononuclear cell migration
0.55	GO:0090025	regulation of monocyte chemotaxis

0.85	GO:0004950	chemokine receptor activity
0.42	GO:0019957	C-C chemokine binding
0.36	GO:0004435	phosphatidylinositol phospholipase C activity
0.35	GO:0004535	poly(A)-specific ribonuclease activity
0.35	GO:0031727	CCR2 chemokine receptor binding
0.34	GO:0003779	actin binding
0.33	GO:0008270	zinc ion binding

0.56	GO:0009897	external side of plasma membrane
0.40	GO:0043025	neuronal cell body
0.34	GO:0005768	endosome
0.34	GO:0005887	integral component of plasma membrane

0.36	EC:3.1.4.11	GO:0004435
0.36	KEGG:R03435	GO:0004435

sp|P51681|CCR5_HUMAN
C-C chemokine receptor type 5
Search

CCR5

0.93	CC chemokine receptor 5 variant

0.84	GO:0070098	chemokine-mediated signaling pathway
0.80	GO:0006954	inflammatory response
0.74	GO:0006955	immune response
0.71	GO:0006935	chemotaxis
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.42	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
0.42	GO:0070723	response to cholesterol
0.40	GO:0071222	cellular response to lipopolysaccharide
0.40	GO:0019722	calcium-mediated signaling
0.40	GO:0000165	MAPK cascade

0.85	GO:0016493	C-C chemokine receptor activity
0.43	GO:0071791	chemokine (C-C motif) ligand 5 binding
0.39	GO:0003779	actin binding
0.35	GO:0104005	hijacked molecular function
0.34	GO:0015026	coreceptor activity
0.34	GO:0004435	phosphatidylinositol phospholipase C activity

0.41	GO:0005886	plasma membrane
0.40	GO:0009986	cell surface
0.39	GO:0098552	side of membrane
0.39	GO:0005768	endosome
0.30	GO:0016021	integral component of membrane

0.34	EC:3.1.4.11	GO:0004435
0.34	KEGG:R03435	GO:0004435

sp|P51684|CCR6_HUMAN
C-C chemokine receptor type 6
Search

CCR6

0.84	CC Chemokine LARC specific receptor

0.84	GO:0070098	chemokine-mediated signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.71	GO:0006935	chemotaxis
0.66	GO:0006955	immune response
0.60	GO:0060474	positive regulation of flagellated sperm motility involved in capacitation
0.56	GO:1904156	DN3 thymocyte differentiation
0.56	GO:1904155	DN2 thymocyte differentiation
0.56	GO:0072679	thymocyte migration
0.55	GO:0006954	inflammatory response
0.55	GO:0019722	calcium-mediated signaling

0.84	GO:0004950	chemokine receptor activity
0.66	GO:0019956	chemokine binding
0.39	GO:0005044	scavenger receptor activity
0.36	GO:0051916	granulocyte colony-stimulating factor binding
0.36	GO:0015026	coreceptor activity
0.34	GO:0004985	opioid receptor activity
0.33	GO:0042923	neuropeptide binding
0.32	GO:0008270	zinc ion binding

0.59	GO:0097524	sperm plasma membrane
0.57	GO:0097225	sperm midpiece
0.57	GO:0097228	sperm principal piece
0.54	GO:0009986	cell surface
0.49	GO:0098552	side of membrane
0.44	GO:0044459	plasma membrane part
0.41	GO:0042629	mast cell granule
0.33	GO:0030667	secretory granule membrane
0.32	GO:0043005	neuron projection
0.32	GO:0033644	host cell membrane

sp|P51685|CCR8_HUMAN
C-C chemokine receptor type 8
Search

CCR8

0.93	C-C motif chemokine receptor 8

0.84	GO:0070098	chemokine-mediated signaling pathway
0.71	GO:0006935	chemotaxis
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.64	GO:0006955	immune response
0.63	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.57	GO:0006954	inflammatory response
0.53	GO:0090026	positive regulation of monocyte chemotaxis
0.44	GO:0051094	positive regulation of developmental process
0.43	GO:0051240	positive regulation of multicellular organismal process
0.43	GO:2000026	regulation of multicellular organismal development

0.84	GO:0004950	chemokine receptor activity
0.49	GO:0019956	chemokine binding
0.40	GO:0004435	phosphatidylinositol phospholipase C activity
0.36	GO:0015026	coreceptor activity
0.33	GO:0004983	neuropeptide Y receptor activity

0.40	GO:0009897	external side of plasma membrane
0.35	GO:0042629	mast cell granule
0.35	GO:0005887	integral component of plasma membrane

0.40	EC:3.1.4.11	GO:0004435
0.40	KEGG:R03435	GO:0004435

sp|P51686|CCR9_HUMAN
C-C chemokine receptor type 9
Search

CCR9

0.94	LOW QUALITY PROTEIN: C-C chemokine receptor type 9

0.80	GO:0070098	chemokine-mediated signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.69	GO:0006935	chemotaxis
0.62	GO:0002304	gamma-delta intraepithelial T cell differentiation
0.60	GO:0006955	immune response
0.48	GO:0006898	receptor-mediated endocytosis
0.46	GO:0006954	inflammatory response
0.39	GO:0006968	cellular defense response
0.39	GO:0038112	interleukin-8-mediated signaling pathway
0.38	GO:0007204	positive regulation of cytosolic calcium ion concentration

0.81	GO:0004950	chemokine receptor activity
0.59	GO:0019956	chemokine binding
0.51	GO:0005044	scavenger receptor activity
0.41	GO:0004992	platelet activating factor receptor activity
0.40	GO:0015054	gastrin receptor activity
0.38	GO:0004982	N-formyl peptide receptor activity
0.38	GO:0004947	bradykinin receptor activity
0.36	GO:0001875	lipopolysaccharide receptor activity
0.36	GO:0015026	coreceptor activity
0.35	GO:0001530	lipopolysaccharide binding

0.54	GO:0009986	cell surface
0.39	GO:0005887	integral component of plasma membrane
0.39	GO:0031965	nuclear membrane
0.38	GO:0005884	actin filament
0.37	GO:0005654	nucleoplasm
0.37	GO:0005829	cytosol
0.36	GO:0042629	mast cell granule
0.35	GO:0005768	endosome
0.33	GO:0098552	side of membrane
0.32	GO:0043005	neuron projection

0.33	EC:3.1.4.11	GO:0004435
0.33	KEGG:R03435	GO:0004435

sp|P51687|SUOX_HUMAN
Sulfite oxidase, mitochondrial
Search

SUOX

0.69	Truncated mitochondrial sulfite oxidase

0.76	GO:0042128	nitrate assimilation
0.52	GO:0055114	oxidation-reduction process
0.37	GO:0006790	sulfur compound metabolic process
0.35	GO:0007584	response to nutrient
0.32	GO:0005975	carbohydrate metabolic process
0.32	GO:0006468	protein phosphorylation

0.76	GO:0030151	molybdenum ion binding
0.62	GO:0020037	heme binding
0.59	GO:0043546	molybdopterin cofactor binding
0.54	GO:0016491	oxidoreductase activity
0.35	GO:0003924	GTPase activity
0.34	GO:0032550	purine ribonucleoside binding
0.34	GO:0019001	guanyl nucleotide binding
0.33	GO:0005515	protein binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0005739	mitochondrion
0.40	GO:0031970	organelle envelope lumen
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.54

GO:0016491

sp|P51688|SPHM_HUMAN
N-sulphoglucosamine sulphohydrolase
Search

SGSH

0.84	N-sulphoglucosamine sulphohydrolase

0.61	GO:0030200	heparan sulfate proteoglycan catabolic process
0.52	GO:0006027	glycosaminoglycan catabolic process

0.74	GO:0008484	sulfuric ester hydrolase activity
0.62	GO:0016250	N-sulfoglucosamine sulfohydrolase activity
0.37	GO:0005515	protein binding
0.33	GO:0046872	metal ion binding

0.54	GO:0005764	lysosome
0.36	GO:0070062	extracellular exosome
0.36	GO:0005775	vacuolar lumen
0.30	GO:0044425	membrane part

0.74

GO:0008484

sp|P51689|ARSD_HUMAN
Arylsulfatase D
Search

ARSD

0.47	Arylsulfatase D

0.39	GO:0006687	glycosphingolipid metabolic process
0.39	GO:0043687	post-translational protein modification
0.34	GO:0001501	skeletal system development

0.73	GO:0008484	sulfuric ester hydrolase activity
0.35	GO:0046872	metal ion binding

0.43	GO:0005794	Golgi apparatus
0.39	GO:0005788	endoplasmic reticulum lumen
0.38	GO:0070062	extracellular exosome
0.35	GO:0005764	lysosome
0.34	GO:0031984	organelle subcompartment
0.30	GO:0044425	membrane part

0.73

GO:0008484

sp|P51690|ARSE_HUMAN
Arylsulfatase E
Search

ARSE

0.45	Arylsulfatase E

0.38	GO:0006687	glycosphingolipid metabolic process
0.38	GO:0043687	post-translational protein modification
0.35	GO:0001501	skeletal system development

0.73	GO:0008484	sulfuric ester hydrolase activity
0.35	GO:0046872	metal ion binding

0.46	GO:0005794	Golgi apparatus
0.38	GO:0005788	endoplasmic reticulum lumen
0.37	GO:0070062	extracellular exosome
0.36	GO:0031984	organelle subcompartment
0.34	GO:0005764	lysosome
0.30	GO:0016021	integral component of membrane

0.73

GO:0008484

sp|P51692|STA5B_HUMAN
Signal transducer and activator of transcription 5B
Search

STAT5B

0.70	Signal transducer and activator of transcription

0.86	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
0.57	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0046543	development of secondary female sexual characteristics
0.56	GO:0008284	positive regulation of cell proliferation
0.56	GO:0046544	development of secondary male sexual characteristics
0.56	GO:0045647	negative regulation of erythrocyte differentiation
0.55	GO:0001779	natural killer cell differentiation

0.64	GO:0004871	signal transducer activity
0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.52	GO:0035259	glucocorticoid receptor binding
0.47	GO:0001067	regulatory region nucleic acid binding
0.44	GO:0046983	protein dimerization activity
0.39	GO:0003682	chromatin binding
0.36	GO:0004713	protein tyrosine kinase activity

0.61	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.43	GO:0070013	intracellular organelle lumen
0.40	GO:0044446	intracellular organelle part
0.30	GO:0044425	membrane part

0.36

GO:0004713

sp|P51693|APLP1_HUMAN
Amyloid-like protein 1
Search

APLP1

0.87	Amyloid beta precursor like protein 1

0.71	GO:0071874	cellular response to norepinephrine stimulus
0.70	GO:0106072	negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.43	GO:0007399	nervous system development
0.40	GO:0051172	negative regulation of nitrogen compound metabolic process
0.40	GO:0032268	regulation of cellular protein metabolic process
0.40	GO:0031324	negative regulation of cellular metabolic process
0.39	GO:0052548	regulation of endopeptidase activity
0.39	GO:0051346	negative regulation of hydrolase activity
0.38	GO:0030817	regulation of cAMP biosynthetic process
0.38	GO:0006378	mRNA polyadenylation

0.82	GO:0008201	heparin binding
0.72	GO:0031695	alpha-2B adrenergic receptor binding
0.71	GO:0031696	alpha-2C adrenergic receptor binding
0.70	GO:0031694	alpha-2A adrenergic receptor binding
0.58	GO:0046914	transition metal ion binding
0.57	GO:0042802	identical protein binding
0.40	GO:0004867	serine-type endopeptidase inhibitor activity

0.61	GO:0048471	perinuclear region of cytoplasm
0.46	GO:0005886	plasma membrane
0.36	GO:0005794	Golgi apparatus
0.30	GO:0016021	integral component of membrane

sp|P51784|UBP11_HUMAN
Ubiquitin carboxyl-terminal hydrolase 11
Search

USP11

0.83	Ubiquitin carboxyl-terminal hydrolase 4

0.76	GO:0016579	protein deubiquitination
0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.36	GO:0034122	negative regulation of toll-like receptor signaling pathway
0.35	GO:0034394	protein localization to cell surface
0.35	GO:0000244	spliceosomal tri-snRNP complex assembly
0.35	GO:0031397	negative regulation of protein ubiquitination
0.34	GO:0031647	regulation of protein stability
0.33	GO:0006468	protein phosphorylation

0.76	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.38	GO:0004197	cysteine-type endopeptidase activity
0.36	GO:0031685	adenosine receptor binding
0.34	GO:0042802	identical protein binding
0.33	GO:0004672	protein kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.52	GO:0005654	nucleoplasm
0.52	GO:0005829	cytosol
0.38	GO:0005694	chromosome
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.76

GO:0036459

sp|P51786|ZN157_HUMAN
Zinc finger protein 157
Search

0.46	LOW QUALITY PROTEIN: zinc finger protein 157

0.53	GO:1903506	regulation of nucleic acid-templated transcription
0.53	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.52	GO:0010468	regulation of gene expression
0.36	GO:0006351	transcription, DNA-templated
0.30	GO:0010558	negative regulation of macromolecule biosynthetic process
0.30	GO:0048523	negative regulation of cellular process
0.30	GO:0051172	negative regulation of nitrogen compound metabolic process

0.51	GO:0003676	nucleic acid binding
0.50	GO:0046872	metal ion binding
0.39	GO:0003700	DNA binding transcription factor activity
0.36	GO:0005515	protein binding

0.43	GO:0005622	intracellular
0.36	GO:0043227	membrane-bounded organelle
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0043228	non-membrane-bounded organelle
0.32	GO:0044422	organelle part

sp|P51787|KCNQ1_HUMAN
Potassium voltage-gated channel subfamily KQT member 1
Search

KCNQ1

0.56	Potassium voltage-gated channel subfamily KQT member 1

0.70	GO:0071805	potassium ion transmembrane transport
0.58	GO:0060453	regulation of gastric acid secretion
0.58	GO:0086009	membrane repolarization
0.58	GO:0003014	renal system process
0.57	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization
0.56	GO:0060452	positive regulation of cardiac muscle contraction
0.56	GO:0086014	atrial cardiac muscle cell action potential
0.55	GO:0086005	ventricular cardiac muscle cell action potential
0.55	GO:0010460	positive regulation of heart rate
0.55	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization

0.74	GO:0005249	voltage-gated potassium channel activity
0.56	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.55	GO:0034236	protein kinase A catalytic subunit binding
0.54	GO:0034237	protein kinase A regulatory subunit binding
0.54	GO:0097110	scaffold protein binding
0.54	GO:0008157	protein phosphatase 1 binding
0.53	GO:0044325	ion channel binding
0.53	GO:0005516	calmodulin binding
0.35	GO:0042803	protein homodimerization activity

0.74	GO:0008076	voltage-gated potassium channel complex
0.55	GO:0016323	basolateral plasma membrane
0.54	GO:0098857	membrane microdomain
0.54	GO:0005769	early endosome
0.51	GO:0005770	late endosome
0.51	GO:0005764	lysosome
0.49	GO:0005783	endoplasmic reticulum
0.43	GO:0030659	cytoplasmic vesicle membrane
0.36	GO:0042588	zymogen granule
0.36	GO:0042383	sarcolemma

sp|P51788|CLCN2_HUMAN
Chloride channel protein 2
Search

CLCN2

0.51	Chloride voltage-gated channel 2

0.76	GO:1902476	chloride transmembrane transport
0.60	GO:0060689	cell differentiation involved in salivary gland development
0.56	GO:0060041	retina development in camera-type eye
0.40	GO:0034765	regulation of ion transmembrane transport
0.35	GO:0030324	lung development
0.33	GO:0010469	regulation of receptor activity

0.78	GO:0005247	voltage-gated chloride channel activity
0.36	GO:0005515	protein binding
0.34	GO:0030545	receptor regulator activity

0.41	GO:0030054	cell junction
0.41	GO:0034707	chloride channel complex
0.35	GO:0043204	perikaryon
0.35	GO:0005886	plasma membrane
0.35	GO:0030425	dendrite
0.34	GO:0015629	actin cytoskeleton
0.33	GO:0005576	extracellular region

sp|P51790|CLCN3_HUMAN
H(+)/Cl(-) exchange transporter 3
Search

CLCN3

0.51	Chloride channel protein (Fragment)

0.76	GO:1902476	chloride transmembrane transport
0.56	GO:0045794	negative regulation of cell volume

0.78	GO:0005247	voltage-gated chloride channel activity
0.57	GO:0072320	volume-sensitive chloride channel activity
0.53	GO:0030165	PDZ domain binding
0.48	GO:0046982	protein heterodimerization activity

0.54	GO:0042581	specific granule
0.52	GO:0045335	phagocytic vesicle
0.51	GO:0005770	late endosome
0.51	GO:0005769	early endosome
0.51	GO:0008021	synaptic vesicle
0.51	GO:0009897	external side of plasma membrane
0.49	GO:0012506	vesicle membrane
0.48	GO:0005794	Golgi apparatus
0.40	GO:0005887	integral component of plasma membrane

sp|P51793|CLCN4_HUMAN
H(+)/Cl(-) exchange transporter 4
Search

CLCN4

0.52	Chloride channel protein (Fragment)

0.76

GO:1902476

chloride transmembrane transport

0.77	GO:0005247	voltage-gated chloride channel activity
0.47	GO:0015297	antiporter activity
0.41	GO:0042802	identical protein binding

0.48	GO:0012505	endomembrane system
0.45	GO:0031984	organelle subcompartment
0.43	GO:0045177	apical part of cell
0.42	GO:0043231	intracellular membrane-bounded organelle
0.42	GO:0044444	cytoplasmic part
0.41	GO:0005887	integral component of plasma membrane
0.36	GO:0097708	intracellular vesicle

sp|P51795|CLCN5_HUMAN
H(+)/Cl(-) exchange transporter 5
Search

CLCN5

0.57	H(+)/Cl(-) exchange transporter 5

0.77	GO:1902476	chloride transmembrane transport
0.48	GO:0007588	excretion
0.48	GO:0006897	endocytosis

0.78	GO:0005247	voltage-gated chloride channel activity
0.65	GO:0015297	antiporter activity
0.53	GO:0042802	identical protein binding
0.51	GO:0032559	adenyl ribonucleotide binding
0.50	GO:0008144	drug binding
0.50	GO:0035639	purine ribonucleoside triphosphate binding

0.71	GO:0010008	endosome membrane
0.66	GO:0000139	Golgi membrane
0.57	GO:0045177	apical part of cell
0.55	GO:0005887	integral component of plasma membrane
0.53	GO:0005765	lysosomal membrane
0.47	GO:0005829	cytosol
0.44	GO:0005770	late endosome
0.44	GO:0005769	early endosome
0.42	GO:0005789	endoplasmic reticulum membrane

sp|P51797|CLCN6_HUMAN
Chloride transport protein 6
Search

CLCN6

0.52	Chloride voltage-gated channel 6

0.76	GO:1902476	chloride transmembrane transport
0.39	GO:0009612	response to mechanical stimulus
0.35	GO:0006884	cell volume homeostasis
0.33	GO:0007165	signal transduction

0.77	GO:0005247	voltage-gated chloride channel activity
0.36	GO:0015297	antiporter activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.37	GO:0010008	endosome membrane
0.37	GO:0005765	lysosomal membrane
0.30	GO:0016021	integral component of membrane

sp|P51798|CLCN7_HUMAN
H(+)/Cl(-) exchange transporter 7
Search

CLCN7

0.51	Chloride voltage-gated channel 7

0.76	GO:1902476	chloride transmembrane transport
0.35	GO:0009268	response to pH

0.77

GO:0005247

voltage-gated chloride channel activity

0.47	GO:0005654	nucleoplasm
0.34	GO:0031410	cytoplasmic vesicle
0.30	GO:0031224	intrinsic component of membrane

sp|P51800|CLCKA_HUMAN
Chloride channel protein ClC-Ka
Search

0.51	Chloride voltage-gated channel Ka

0.77	GO:1902476	chloride transmembrane transport
0.44	GO:0034765	regulation of ion transmembrane transport
0.41	GO:0072053	renal inner medulla development
0.39	GO:0050878	regulation of body fluid levels
0.39	GO:0007588	excretion
0.36	GO:0030321	transepithelial chloride transport
0.36	GO:0051592	response to calcium ion
0.35	GO:0009268	response to pH
0.35	GO:0009414	response to water deprivation
0.34	GO:0046903	secretion

0.78	GO:0005247	voltage-gated chloride channel activity
0.40	GO:0042802	identical protein binding
0.37	GO:0046872	metal ion binding

0.45	GO:0034707	chloride channel complex
0.39	GO:0016323	basolateral plasma membrane
0.37	GO:0005887	integral component of plasma membrane
0.35	GO:0012505	endomembrane system
0.35	GO:0016324	apical plasma membrane
0.34	GO:0030054	cell junction
0.34	GO:0098588	bounding membrane of organelle
0.34	GO:0031984	organelle subcompartment
0.34	GO:0043231	intracellular membrane-bounded organelle
0.34	GO:0044444	cytoplasmic part

sp|P51801|CLCKB_HUMAN
Chloride channel protein ClC-Kb
Search

0.51	Chloride voltage-gated channel Ka

0.77	GO:1902476	chloride transmembrane transport
0.44	GO:0034765	regulation of ion transmembrane transport
0.42	GO:0072053	renal inner medulla development
0.39	GO:0050878	regulation of body fluid levels
0.39	GO:0007588	excretion
0.36	GO:0030321	transepithelial chloride transport
0.36	GO:0051592	response to calcium ion
0.36	GO:0009268	response to pH
0.35	GO:0009414	response to water deprivation
0.34	GO:0046903	secretion

0.78	GO:0005247	voltage-gated chloride channel activity
0.40	GO:0042802	identical protein binding
0.37	GO:0046872	metal ion binding

0.45	GO:0034707	chloride channel complex
0.39	GO:0016323	basolateral plasma membrane
0.37	GO:0005887	integral component of plasma membrane
0.35	GO:0012505	endomembrane system
0.35	GO:0016324	apical plasma membrane
0.34	GO:0098588	bounding membrane of organelle
0.34	GO:0031984	organelle subcompartment
0.34	GO:0043231	intracellular membrane-bounded organelle
0.34	GO:0044444	cytoplasmic part

sp|P51805|PLXA3_HUMAN
Plexin-A3
Search

PLXNA3

0.97	Plexin A3 (Predicted)

0.83	GO:0071526	semaphorin-plexin signaling pathway
0.63	GO:0021785	branchiomotor neuron axon guidance
0.62	GO:0048841	regulation of axon extension involved in axon guidance
0.60	GO:0021637	trigeminal nerve structural organization
0.60	GO:0021860	pyramidal neuron development
0.59	GO:0021612	facial nerve structural organization
0.59	GO:1902668	negative regulation of axon guidance
0.58	GO:0030517	negative regulation of axon extension
0.57	GO:0050919	negative chemotaxis
0.57	GO:1990138	neuron projection extension

0.84	GO:0017154	semaphorin receptor activity
0.35	GO:0005515	protein binding
0.33	GO:0003677	DNA binding

0.52	GO:0030054	cell junction
0.46	GO:0005634	nucleus
0.43	GO:0005886	plasma membrane
0.37	GO:0002116	semaphorin receptor complex
0.30	GO:0016021	integral component of membrane

sp|P51808|DYLT3_HUMAN
Dynein light chain Tctex-type 3
Search

DYNLT3

0.94	Dynein light chain Tctex-type 3

0.58	GO:0019060	intracellular transport of viral protein in host cell
0.49	GO:0007346	regulation of mitotic cell cycle
0.46	GO:0045787	positive regulation of cell cycle
0.43	GO:0051301	cell division
0.43	GO:0007049	cell cycle

0.72	GO:0042802	identical protein binding
0.45	GO:0003774	motor activity

0.83	GO:0005868	cytoplasmic dynein complex
0.72	GO:0000776	kinetochore
0.60	GO:0005881	cytoplasmic microtubule
0.53	GO:0099503	secretory vesicle
0.48	GO:0005818	aster
0.48	GO:0000779	condensed chromosome, centromeric region
0.46	GO:0005876	spindle microtubule
0.46	GO:0072686	mitotic spindle
0.46	GO:0044217	other organism part
0.46	GO:0018995	host

sp|P51809|VAMP7_HUMAN
Vesicle-associated membrane protein 7
Search

VAMP7

0.93	Vesicle associated membrane protein 7

0.67	GO:0016192	vesicle-mediated transport
0.55	GO:0002278	eosinophil activation involved in immune response
0.55	GO:0002447	eosinophil mediated immunity
0.54	GO:0090174	organelle membrane fusion
0.53	GO:1903595	positive regulation of histamine secretion by mast cell
0.53	GO:0007041	lysosomal transport
0.53	GO:0002283	neutrophil activation involved in immune response
0.53	GO:0016050	vesicle organization
0.53	GO:0002446	neutrophil mediated immunity
0.53	GO:1900483	regulation of protein targeting to vacuolar membrane

0.47	GO:0000149	SNARE binding
0.47	GO:0005484	SNAP receptor activity
0.32	GO:0003676	nucleic acid binding

0.54	GO:0031143	pseudopodium
0.53	GO:0031201	SNARE complex
0.53	GO:0035577	azurophil granule membrane
0.52	GO:0031091	platelet alpha granule
0.51	GO:0030027	lamellipodium
0.49	GO:0045335	phagocytic vesicle
0.48	GO:0005802	trans-Golgi network
0.47	GO:0045177	apical part of cell
0.47	GO:0043005	neuron projection
0.47	GO:0030133	transport vesicle

sp|P51810|GP143_HUMAN
G-protein coupled receptor 143
Search

GPR143

0.66	G-protein coupled receptor

0.69	GO:0007186	G-protein coupled receptor signaling pathway
0.64	GO:0032438	melanosome organization
0.59	GO:0035584	calcium-mediated signaling using intracellular calcium source
0.59	GO:0032402	melanosome transport
0.57	GO:0050848	regulation of calcium-mediated signaling
0.55	GO:0048015	phosphatidylinositol-mediated signaling
0.50	GO:1903056	regulation of melanosome organization
0.50	GO:1902908	regulation of melanosome transport
0.43	GO:0007166	cell surface receptor signaling pathway
0.37	GO:0006726	eye pigment biosynthetic process

0.86	GO:0072544	L-DOPA binding
0.86	GO:0072545	tyrosine binding
0.85	GO:0035240	dopamine binding
0.70	GO:0004930	G-protein coupled receptor activity
0.54	GO:0001653	peptide receptor activity
0.34	GO:0005515	protein binding

0.59	GO:0033162	melanosome membrane
0.55	GO:0005765	lysosomal membrane
0.55	GO:0016324	apical plasma membrane
0.50	GO:0005794	Golgi apparatus
0.30	GO:0016021	integral component of membrane

sp|P51811|XK_HUMAN
Membrane transport protein XK
Search

sp|P51812|KS6A3_HUMAN
Ribosomal protein S6 kinase alpha-3
Search

RPS6KA3

0.73	Ribosomal protein S6 kinase alpha-3

0.63	GO:0006468	protein phosphorylation
0.62	GO:0035556	intracellular signal transduction
0.53	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.51	GO:0002224	toll-like receptor signaling pathway
0.51	GO:0032496	response to lipopolysaccharide
0.50	GO:0006915	apoptotic process
0.49	GO:0045944	positive regulation of transcription by RNA polymerase II
0.37	GO:0043588	skin development
0.37	GO:0048565	digestive tract development
0.35	GO:0033554	cellular response to stress

0.70	GO:0004674	protein serine/threonine kinase activity
0.64	GO:0000287	magnesium ion binding
0.55	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0019901	protein kinase binding
0.35	GO:0003743	translation initiation factor activity

0.45	GO:0005622	intracellular
0.39	GO:0043227	membrane-bounded organelle
0.36	GO:0043228	non-membrane-bounded organelle
0.36	GO:0031974	membrane-enclosed lumen
0.35	GO:1990904	ribonucleoprotein complex
0.34	GO:0044422	organelle part

0.70

GO:0004674

sp|P51813|BMX_HUMAN
Cytoplasmic tyrosine-protein kinase BMX
Search

BMX

0.58	Tyrosine-protein kinase

0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.60	GO:0035556	intracellular signal transduction
0.58	GO:0046777	protein autophosphorylation
0.52	GO:0030098	lymphocyte differentiation
0.50	GO:0098761	cellular response to interleukin-7
0.50	GO:0042127	regulation of cell proliferation
0.49	GO:0006955	immune response
0.48	GO:0050869	negative regulation of B cell activation
0.47	GO:0002377	immunoglobulin production
0.47	GO:0042113	B cell activation

0.81	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.54	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.45	GO:0042802	identical protein binding
0.44	GO:0005102	receptor binding
0.37	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.37	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding

0.56	GO:0032587	ruffle membrane
0.49	GO:0005654	nucleoplasm
0.47	GO:0098857	membrane microdomain
0.47	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.43	GO:0031410	cytoplasmic vesicle
0.43	GO:0005829	cytosol
0.36	GO:0042629	mast cell granule
0.35	GO:0048471	perinuclear region of cytoplasm
0.33	GO:0005911	cell-cell junction
0.33	GO:0005856	cytoskeleton

0.81

GO:0004715

sp|P51814|ZNF41_HUMAN
Zinc finger protein 41
Search

ZNF484

0.83	Zinc finger protein 41

0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:0010468	regulation of gene expression
0.36	GO:0097659	nucleic acid-templated transcription
0.35	GO:0010467	gene expression
0.35	GO:0034645	cellular macromolecule biosynthetic process

0.53	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.42	GO:0003700	DNA binding transcription factor activity
0.30	GO:0005515	protein binding

0.44	GO:0005622	intracellular
0.35	GO:0043227	membrane-bounded organelle

sp|P51815|ZN75D_HUMAN
Zinc finger protein 75D
Search

ZNF75D

0.97	Zinc finger protein 75D

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.51	GO:0006351	transcription, DNA-templated
0.33	GO:1902679	negative regulation of RNA biosynthetic process
0.33	GO:0007219	Notch signaling pathway
0.33	GO:0014022	neural plate elongation
0.33	GO:0060029	convergent extension involved in organogenesis
0.33	GO:0060028	convergent extension involved in axis elongation
0.33	GO:0060669	embryonic placenta morphogenesis

0.57	GO:0003700	DNA binding transcription factor activity
0.51	GO:0046872	metal ion binding
0.50	GO:0003676	nucleic acid binding
0.33	GO:0005515	protein binding
0.33	GO:0003682	chromatin binding

0.57	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P51816|AFF2_HUMAN
AF4/FMR2 family member 2
Search

sp|P51817|PRKX_HUMAN
cAMP-dependent protein kinase catalytic subunit PRKX
Search

PRKX

0.93	Protein kinase, X-linked

0.63	GO:0006468	protein phosphorylation
0.60	GO:2000696	regulation of epithelial cell differentiation involved in kidney development
0.60	GO:0001935	endothelial cell proliferation
0.59	GO:0043542	endothelial cell migration
0.58	GO:0060993	kidney morphogenesis
0.57	GO:0030099	myeloid cell differentiation
0.56	GO:0001525	angiogenesis
0.56	GO:0018209	peptidyl-serine modification
0.56	GO:0031589	cell-substrate adhesion
0.56	GO:0060562	epithelial tube morphogenesis

0.69	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0060089	molecular transducer activity

0.46	GO:0005634	nucleus
0.40	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.69

GO:0004674

sp|P51825|AFF1_HUMAN
AF4/FMR2 family member 1
Search

AFF1

0.97	LOW QUALITY PROTEIN: AF4/FMR2 family member 1-like

0.52	GO:0007286	spermatid development
0.41	GO:0045893	positive regulation of transcription, DNA-templated
0.36	GO:0006368	transcription elongation from RNA polymerase II promoter

0.39	GO:0003700	DNA binding transcription factor activity
0.38	GO:0005515	protein binding

0.79	GO:0008023	transcription elongation factor complex
0.53	GO:0035327	transcriptionally active chromatin
0.52	GO:0001650	fibrillar center

sp|P51826|AFF3_HUMAN
AF4/FMR2 family member 3
Search

0.79	AF4/FMR2 family member 3 isoform A

0.85	GO:0035116	embryonic hindlimb morphogenesis
0.82	GO:0034612	response to tumor necrosis factor
0.49	GO:0035063	nuclear speck organization
0.45	GO:0043484	regulation of RNA splicing
0.40	GO:0006351	transcription, DNA-templated
0.39	GO:1903506	regulation of nucleic acid-templated transcription
0.39	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.39	GO:0007611	learning or memory
0.37	GO:0010629	negative regulation of gene expression

0.70	GO:0003690	double-stranded DNA binding
0.40	GO:0002151	G-quadruplex RNA binding
0.36	GO:0003700	DNA binding transcription factor activity

0.76	GO:0016604	nuclear body
0.66	GO:0005829	cytosol

sp|P51828|ADCY7_HUMAN
Adenylate cyclase type 7
Search

ADCY7

0.88	Adenylate cyclase type 7

0.79	GO:0006171	cAMP biosynthetic process
0.62	GO:0035556	intracellular signal transduction
0.59	GO:0071361	cellular response to ethanol
0.48	GO:0006182	cGMP biosynthetic process
0.40	GO:0060135	maternal process involved in female pregnancy
0.40	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
0.39	GO:0007190	activation of adenylate cyclase activity
0.37	GO:0034199	activation of protein kinase A activity
0.37	GO:0071377	cellular response to glucagon stimulus
0.37	GO:0003091	renal water homeostasis

0.79	GO:0004016	adenylate cyclase activity
0.52	GO:0032559	adenyl ribonucleotide binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0004383	guanylate cyclase activity
0.35	GO:0005080	protein kinase C binding
0.34	GO:0046872	metal ion binding

0.55	GO:0005886	plasma membrane
0.49	GO:0008074	guanylate cyclase complex, soluble
0.34	GO:0030425	dendrite
0.30	GO:0016021	integral component of membrane

0.79

EC:4.6.1.1

GO:0004016

sp|P51841|GUC2F_HUMAN
Retinal guanylyl cyclase 2
Search

GUCY2F

0.57	Guanylate cyclase

0.82	GO:0006182	cGMP biosynthetic process
0.63	GO:0006468	protein phosphorylation
0.62	GO:0035556	intracellular signal transduction
0.50	GO:0007601	visual perception
0.50	GO:0050962	detection of light stimulus involved in sensory perception
0.47	GO:0009584	detection of visible light
0.45	GO:0035845	photoreceptor cell outer segment organization

0.82	GO:0004383	guanylate cyclase activity
0.63	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0004016	adenylate cyclase activity

0.49	GO:0008074	guanylate cyclase complex, soluble
0.39	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.82

EC:4.6.1.2

GO:0004383

sp|P51843|NR0B1_HUMAN
Nuclear receptor subfamily 0 group B member 1
Search

0.57	Nuclear receptor subfamily 0 group B member 1

0.83	GO:0030325	adrenal gland development
0.78	GO:0043401	steroid hormone mediated signaling pathway
0.57	GO:0006351	transcription, DNA-templated
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.47	GO:2000019	negative regulation of male gonad development
0.45	GO:0030104	water homeostasis
0.43	GO:0051253	negative regulation of RNA metabolic process
0.43	GO:0010558	negative regulation of macromolecule biosynthetic process

0.77	GO:0003707	steroid hormone receptor activity
0.53	GO:0003677	DNA binding
0.47	GO:0003714	transcription corepressor activity
0.44	GO:0019904	protein domain specific binding
0.44	GO:0042803	protein homodimerization activity
0.41	GO:0035257	nuclear hormone receptor binding
0.40	GO:0004879	nuclear receptor activity
0.36	GO:0042975	peroxisome proliferator activated receptor binding
0.36	GO:0003723	RNA binding
0.35	GO:0032403	protein complex binding

0.61	GO:0005634	nucleus
0.42	GO:0042788	polysomal ribosome
0.38	GO:0005815	microtubule organizing center
0.37	GO:0043233	organelle lumen
0.33	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

sp|P51854|TKTL1_HUMAN
Transketolase-like protein 1
Search

0.44	Transketolase b

0.42	GO:0046166	glyceraldehyde-3-phosphate biosynthetic process
0.39	GO:0040008	regulation of growth
0.37	GO:0006007	glucose catabolic process
0.36	GO:0006772	thiamine metabolic process
0.36	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA
0.35	GO:0043085	positive regulation of catalytic activity

0.46	GO:0004802	transketolase activity
0.39	GO:0042803	protein homodimerization activity
0.36	GO:0046872	metal ion binding
0.35	GO:0048037	cofactor binding
0.35	GO:0008047	enzyme activator activity

0.40	GO:0043209	myelin sheath
0.40	GO:0016607	nuclear speck
0.35	GO:0005737	cytoplasm

0.46

EC:2.2.1.1

GO:0004802

sp|P51857|AK1D1_HUMAN
3-oxo-5-beta-steroid 4-dehydrogenase
Search

AKR1D1

0.97	3-oxo-5-beta-steroid 4-dehydrogenase

0.59	GO:0006707	cholesterol catabolic process
0.59	GO:0008207	C21-steroid hormone metabolic process
0.58	GO:0006699	bile acid biosynthetic process
0.58	GO:0008209	androgen metabolic process
0.56	GO:0007586	digestion
0.53	GO:0055114	oxidation-reduction process
0.41	GO:0030573	bile acid catabolic process
0.35	GO:0008284	positive regulation of cell proliferation
0.35	GO:0071799	cellular response to prostaglandin D stimulus
0.34	GO:0044598	doxorubicin metabolic process

0.54	GO:0016491	oxidoreductase activity
0.36	GO:0005496	steroid binding
0.34	GO:0032052	bile acid binding
0.34	GO:0005328	neurotransmitter:sodium symporter activity
0.34	GO:0070401	NADP+ binding
0.34	GO:0070402	NADPH binding

0.48	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.54

GO:0016491

sp|P51858|HDGF_HUMAN
Hepatoma-derived growth factor
Search

HDGF

0.97	Hepatoma-derived growth factor

0.69	GO:0000122	negative regulation of transcription by RNA polymerase II
0.50	GO:0010469	regulation of receptor activity
0.43	GO:0007026	negative regulation of microtubule depolymerization
0.43	GO:0030307	positive regulation of cell growth
0.43	GO:0036498	IRE1-mediated unfolded protein response
0.42	GO:0008283	cell proliferation
0.42	GO:0007010	cytoskeleton organization
0.41	GO:0006351	transcription, DNA-templated
0.41	GO:0031175	neuron projection development
0.41	GO:0051258	protein polymerization

0.80	GO:0001222	transcription corepressor binding
0.77	GO:0001106	RNA polymerase II transcription corepressor activity
0.51	GO:0008083	growth factor activity
0.51	GO:0008201	heparin binding
0.42	GO:0008092	cytoskeletal protein binding
0.41	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.40	GO:0003677	DNA binding
0.40	GO:0003682	chromatin binding
0.39	GO:0001067	regulatory region nucleic acid binding
0.39	GO:1901265	nucleoside phosphate binding

0.72	GO:0017053	transcriptional repressor complex
0.68	GO:0005615	extracellular space
0.66	GO:0031012	extracellular matrix
0.63	GO:0005654	nucleoplasm
0.39	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|P51861|CDR1_HUMAN
Cerebellar degeneration-related antigen 1
Search

CDR1

0.97	Cerebellar degeneration-related antigen 1

0.63

GO:0005515

protein binding

sp|P51864|TDGF3_HUMAN
Putative teratocarcinoma-derived growth factor 3
Search

TDGF1

0.97	Teratocarcinoma-derived growth factor

0.77	GO:0035729	cellular response to hepatocyte growth factor stimulus
0.76	GO:0002042	cell migration involved in sprouting angiogenesis
0.76	GO:0010469	regulation of receptor activity
0.75	GO:0071354	cellular response to interleukin-6
0.75	GO:0071364	cellular response to epidermal growth factor stimulus
0.73	GO:0071346	cellular response to interferon-gamma
0.73	GO:0010595	positive regulation of endothelial cell migration
0.72	GO:0000187	activation of MAPK activity
0.71	GO:0071356	cellular response to tumor necrosis factor
0.71	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation

0.78	GO:0008083	growth factor activity
0.45	GO:0038100	nodal binding
0.44	GO:0070698	type I activin receptor binding
0.43	GO:0017147	Wnt-protein binding
0.42	GO:0015026	coreceptor activity

0.70	GO:0016324	apical plasma membrane
0.69	GO:0045121	membrane raft
0.65	GO:0009986	cell surface
0.63	GO:0005615	extracellular space
0.44	GO:0019897	extrinsic component of plasma membrane
0.43	GO:0031225	anchored component of membrane
0.41	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0005794	Golgi apparatus
0.37	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

sp|P51878|CASP5_HUMAN
Caspase-5
Search

0.88	Caspase-1/caspase-4 hybrid

0.69	GO:0042981	regulation of apoptotic process
0.61	GO:0006508	proteolysis
0.57	GO:0012501	programmed cell death
0.55	GO:0050727	regulation of inflammatory response
0.54	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway
0.51	GO:0050718	positive regulation of interleukin-1 beta secretion
0.49	GO:0071260	cellular response to mechanical stimulus
0.49	GO:0071310	cellular response to organic substance
0.48	GO:0034976	response to endoplasmic reticulum stress
0.48	GO:0010243	response to organonitrogen compound

0.75	GO:0004197	cysteine-type endopeptidase activity
0.53	GO:0050700	CARD domain binding
0.42	GO:0019900	kinase binding
0.41	GO:0042802	identical protein binding
0.40	GO:0097110	scaffold protein binding
0.35	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
0.34	GO:0002020	protease binding

0.62	GO:0061702	inflammasome complex
0.46	GO:0005783	endoplasmic reticulum
0.46	GO:0097179	protease inhibitor complex
0.41	GO:0005739	mitochondrion
0.40	GO:0005576	extracellular region
0.38	GO:0043005	neuron projection
0.38	GO:0043025	neuronal cell body
0.37	GO:0005886	plasma membrane
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0031984	organelle subcompartment

0.75

GO:0004197

sp|P51884|LUM_HUMAN
Lumican
Search

LUM

0.97	Keratan sulfate proteoglycan lumican

0.83	GO:0030199	collagen fibril organization
0.75	GO:0007601	visual perception
0.61	GO:0032914	positive regulation of transforming growth factor beta1 production
0.52	GO:0045944	positive regulation of transcription by RNA polymerase II
0.47	GO:0007409	axonogenesis
0.41	GO:0048596	embryonic camera-type eye morphogenesis
0.39	GO:0051216	cartilage development
0.38	GO:0070848	response to growth factor
0.38	GO:0014070	response to organic cyclic compound
0.37	GO:0042340	keratan sulfate catabolic process

0.59	GO:0005518	collagen binding
0.35	GO:0005201	extracellular matrix structural constituent
0.34	GO:0004672	protein kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.74	GO:0005578	proteinaceous extracellular matrix
0.56	GO:0044420	extracellular matrix component
0.54	GO:0005581	collagen trimer
0.53	GO:0005615	extracellular space
0.51	GO:0099512	supramolecular fiber
0.37	GO:1903561	extracellular vesicle
0.36	GO:0043202	lysosomal lumen
0.36	GO:0005796	Golgi lumen
0.30	GO:0016020	membrane

sp|P51888|PRELP_HUMAN
Prolargin
Search

PRELP

0.97	Proline arginine-rich end leucine-rich repeat

0.56	GO:0007569	cell aging
0.48	GO:0007409	axonogenesis
0.44	GO:0061303	cornea development in camera-type eye
0.36	GO:0042340	keratan sulfate catabolic process
0.36	GO:0018146	keratan sulfate biosynthetic process
0.35	GO:0001501	skeletal system development
0.34	GO:0030199	collagen fibril organization
0.33	GO:0007601	visual perception

0.76	GO:0005201	extracellular matrix structural constituent
0.48	GO:0008201	heparin binding

0.71	GO:0005578	proteinaceous extracellular matrix
0.53	GO:0005615	extracellular space
0.46	GO:1903561	extracellular vesicle
0.36	GO:0043202	lysosomal lumen
0.36	GO:0005796	Golgi lumen
0.30	GO:0031224	intrinsic component of membrane

sp|P51911|CNN1_HUMAN
Calponin-1
Search

CNN1

0.89

Calponin

0.82	GO:0031032	actomyosin structure organization
0.64	GO:1904706	negative regulation of vascular smooth muscle cell proliferation
0.39	GO:0043535	regulation of blood vessel endothelial cell migration
0.38	GO:0043408	regulation of MAPK cascade
0.36	GO:0006940	regulation of smooth muscle contraction

0.77	GO:0005516	calmodulin binding
0.74	GO:0003779	actin binding

0.55	GO:0005856	cytoskeleton
0.38	GO:0005925	focal adhesion

sp|P51946|CCNH_HUMAN
Cyclin-H
Search

CCNH

0.90

Cyclin-H

0.75	GO:0045859	regulation of protein kinase activity
0.58	GO:0006351	transcription, DNA-templated
0.52	GO:0045944	positive regulation of transcription by RNA polymerase II
0.51	GO:0050821	protein stabilization
0.49	GO:1901409	positive regulation of phosphorylation of RNA polymerase II C-terminal domain
0.46	GO:0045787	positive regulation of cell cycle
0.46	GO:0033674	positive regulation of kinase activity
0.45	GO:0006468	protein phosphorylation
0.38	GO:0007049	cell cycle
0.36	GO:0006294	nucleotide-excision repair, preincision complex assembly

0.82	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.54	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.48	GO:0008094	DNA-dependent ATPase activity
0.35	GO:0004693	cyclin-dependent protein serine/threonine kinase activity
0.33	GO:0005515	protein binding

0.84	GO:0070985	TFIIK complex
0.56	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
0.54	GO:0150005	enzyme activator complex
0.36	GO:0042585	germinal vesicle
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.82

GO:0016538

sp|P51948|MAT1_HUMAN
CDK-activating kinase assembly factor MAT1
Search

MNAT1

0.88	MNAT CDK-activating kinase assembly factor 1

0.85	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
0.73	GO:0006289	nucleotide-excision repair
0.57	GO:0007512	adult heart development
0.56	GO:0021591	ventricular system development
0.55	GO:0051592	response to calcium ion
0.51	GO:0016310	phosphorylation
0.51	GO:0006366	transcription by RNA polymerase II
0.50	GO:0045944	positive regulation of transcription by RNA polymerase II
0.45	GO:0036211	protein modification process
0.43	GO:0044267	cellular protein metabolic process

0.85	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity
0.57	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.55	GO:0047485	protein N-terminus binding
0.48	GO:0008094	DNA-dependent ATPase activity
0.42	GO:0004693	cyclin-dependent protein serine/threonine kinase activity
0.34	GO:0008270	zinc ion binding
0.34	GO:0000990	transcription factor activity, core RNA polymerase binding
0.33	GO:0003735	structural constituent of ribosome

0.83	GO:0005675	holo TFIIH complex
0.48	GO:0005829	cytosol
0.36	GO:0042585	germinal vesicle
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.57

EC:2.7.11.23

GO:0008353

sp|P51955|NEK2_HUMAN
Serine/threonine-protein kinase Nek2
Search

NEK2

0.95	Serine/threonine-protein kinase Nek2

0.63	GO:0006468	protein phosphorylation
0.63	GO:1903126	negative regulation of centriole-centriole cohesion
0.60	GO:0046602	regulation of mitotic centrosome separation
0.60	GO:1904355	positive regulation of telomere capping
0.60	GO:0051299	centrosome separation
0.59	GO:0051973	positive regulation of telomerase activity
0.59	GO:0051988	regulation of attachment of spindle microtubules to kinetochore
0.59	GO:0032212	positive regulation of telomere maintenance via telomerase
0.57	GO:0043392	negative regulation of DNA binding
0.56	GO:0090307	mitotic spindle assembly

0.64	GO:0004672	protein kinase activity
0.57	GO:0019903	protein phosphatase binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0046872	metal ion binding
0.33	GO:0001222	transcription corepressor binding
0.33	GO:0019894	kinesin binding
0.33	GO:0033613	activating transcription factor binding

0.55	GO:0030496	midbody
0.55	GO:0005813	centrosome
0.54	GO:0000776	kinetochore
0.53	GO:0000922	spindle pole
0.53	GO:0000794	condensed nuclear chromosome
0.50	GO:0005654	nucleoplasm
0.36	GO:0000779	condensed chromosome, centromeric region
0.36	GO:0005730	nucleolus
0.36	GO:0005874	microtubule
0.34	GO:0005829	cytosol

sp|P51956|NEK3_HUMAN
Serine/threonine-protein kinase Nek3
Search

NEK3

0.91	NIMA related kinase 3

0.72	GO:0090043	regulation of tubulin deacetylation
0.65	GO:0030010	establishment of cell polarity
0.63	GO:0048812	neuron projection morphogenesis
0.63	GO:0006468	protein phosphorylation
0.40	GO:0051155	positive regulation of striated muscle cell differentiation
0.40	GO:2001056	positive regulation of cysteine-type endopeptidase activity

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

sp|P51957|NEK4_HUMAN
Serine/threonine-protein kinase Nek4
Search

NEK4

0.86	NIMA (Never in mitosis gene a)-related kinase 4

0.66	GO:1900062	regulation of replicative cell aging
0.63	GO:2000772	regulation of cellular senescence
0.63	GO:0006468	protein phosphorylation
0.58	GO:2001020	regulation of response to DNA damage stimulus
0.56	GO:0000278	mitotic cell cycle
0.56	GO:0051173	positive regulation of nitrogen compound metabolic process
0.55	GO:0010604	positive regulation of macromolecule metabolic process
0.55	GO:0031325	positive regulation of cellular metabolic process
0.54	GO:0009891	positive regulation of biosynthetic process
0.52	GO:0006974	cellular response to DNA damage stimulus

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0030145	manganese ion binding

0.52	GO:0005829	cytosol
0.38	GO:0035253	ciliary rootlet
0.37	GO:0035869	ciliary transition zone
0.37	GO:0036064	ciliary basal body
0.37	GO:0097014	ciliary plasm

sp|P51959|CCNG1_HUMAN
Cyclin-G1
Search

0.73	GO:0051726	regulation of cell cycle
0.38	GO:0051301	cell division
0.38	GO:0007049	cell cycle
0.35	GO:0006949	syncytium formation
0.34	GO:0071900	regulation of protein serine/threonine kinase activity
0.34	GO:0007420	brain development
0.34	GO:0043066	negative regulation of apoptotic process
0.34	GO:0010243	response to organonitrogen compound
0.33	GO:0006974	cellular response to DNA damage stimulus
0.33	GO:0015991	ATP hydrolysis coupled proton transport

0.33	GO:0005515	protein binding
0.33	GO:0046961	proton-transporting ATPase activity, rotational mechanism
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.38	GO:0005634	nucleus
0.35	GO:0043025	neuronal cell body
0.35	GO:0030425	dendrite
0.34	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0033180	proton-transporting V-type ATPase, V1 domain
0.33	GO:0044446	intracellular organelle part

sp|P51965|UB2E1_HUMAN
Ubiquitin-conjugating enzyme E2 E1
Search

UBE2E1

0.89	Ubiquitin-conjugating enzyme E2 E1 isoform B

0.62	GO:0032020	ISG15-protein conjugation
0.60	GO:0070936	protein K48-linked ubiquitination
0.55	GO:0033523	histone H2B ubiquitination
0.54	GO:0010390	histone monoubiquitination
0.48	GO:0070979	protein K11-linked ubiquitination
0.47	GO:0070534	protein K63-linked ubiquitination
0.46	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
0.40	GO:0006974	cellular response to DNA damage stimulus
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

0.62	GO:0042296	ISG15 transferase activity
0.60	GO:0061631	ubiquitin conjugating enzyme activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding
0.32	GO:0003723	RNA binding

0.50	GO:0000151	ubiquitin ligase complex
0.44	GO:0005634	nucleus
0.34	GO:0005829	cytosol
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

sp|P51970|NDUA8_HUMAN
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
Search

NDUFA8

0.91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

0.70	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
0.58	GO:0032981	mitochondrial respiratory chain complex I assembly

0.52	GO:0032403	protein complex binding
0.34	GO:0008137	NADH dehydrogenase (ubiquinone) activity

0.76	GO:0005747	mitochondrial respiratory chain complex I
0.55	GO:0005758	mitochondrial intermembrane space

0.34

EC:1.6.5.3

GO:0008137

sp|P51991|ROA3_HUMAN
Heterogeneous nuclear ribonucleoprotein A3
Search

HNRNPA3

0.94	Heterogeneous nuclear ribonucleoprotein A3

0.40	GO:0008380	RNA splicing
0.39	GO:0006397	mRNA processing
0.36	GO:0051028	mRNA transport

0.59	GO:0003723	RNA binding
0.38	GO:0051032	nucleic acid transmembrane transporter activity
0.35	GO:0005515	protein binding

0.63	GO:0019013	viral nucleocapsid
0.58	GO:0030529	intracellular ribonucleoprotein complex
0.47	GO:0005654	nucleoplasm
0.43	GO:1902494	catalytic complex
0.36	GO:0043005	neuron projection
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|P51993|FUT6_HUMAN
Alpha-(1,3)-fucosyltransferase 6
Search

0.63	Lewis alpha-3-fucosyltransferase

0.81	GO:0036065	fucosylation
0.74	GO:0006486	protein glycosylation
0.44	GO:0006672	ceramide metabolic process
0.40	GO:0042355	L-fucose catabolic process
0.38	GO:0009312	oligosaccharide biosynthetic process
0.36	GO:0009988	cell-cell recognition

0.81	GO:0008417	fucosyltransferase activity
0.33	GO:0005509	calcium ion binding

0.81	GO:0032580	Golgi cisterna membrane
0.40	GO:0009986	cell surface
0.37	GO:0070062	extracellular exosome
0.35	GO:0071944	cell periphery
0.30	GO:0016021	integral component of membrane

0.81

GO:0008417

sp|P52179|MYOM1_HUMAN
Myomesin-1
Search

MYOM1

0.82	Myomesin family member 1

0.85	GO:0010737	protein kinase A signaling
0.82	GO:0006936	muscle contraction
0.80	GO:0050714	positive regulation of protein secretion
0.69	GO:0010628	positive regulation of gene expression
0.64	GO:0071688	striated muscle myosin thick filament assembly
0.61	GO:0045214	sarcomere organization
0.60	GO:0002074	extraocular skeletal muscle development
0.55	GO:0007015	actin filament organization

0.75	GO:0019900	kinase binding
0.72	GO:0042803	protein homodimerization activity
0.64	GO:0097493	structural molecule activity conferring elasticity
0.64	GO:0051371	muscle alpha-actinin binding
0.63	GO:0008307	structural constituent of muscle
0.57	GO:0051015	actin filament binding
0.33	GO:0005200	structural constituent of cytoskeleton

0.85	GO:0031430	M band
0.63	GO:0005859	muscle myosin complex
0.60	GO:0030018	Z disc
0.50	GO:0032982	myosin filament
0.48	GO:0036379	myofilament

sp|P52198|RND2_HUMAN
Rho-related GTP-binding protein RhoN
Search

RND2

0.97	Rho-related GTP-binding protein RhoN

0.77	GO:0007264	small GTPase mediated signal transduction
0.55	GO:0048672	positive regulation of collateral sprouting

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.65	GO:0032561	guanyl ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0047485	protein N-terminus binding

0.45	GO:0005622	intracellular
0.37	GO:0031982	vesicle
0.37	GO:0012505	endomembrane system
0.36	GO:0097223	sperm part
0.36	GO:0098588	bounding membrane of organelle
0.35	GO:0098805	whole membrane
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P52209|6PGD_HUMAN
6-phosphogluconate dehydrogenase, decarboxylating
Search

PGD

0.58	6-phosphogluconate dehydrogenase, decarboxylating

0.78	GO:0019521	D-gluconate metabolic process
0.71	GO:0006098	pentose-phosphate shunt
0.56	GO:0019322	pentose biosynthetic process
0.52	GO:0055114	oxidation-reduction process
0.35	GO:0007018	microtubule-based movement

0.74	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
0.36	GO:0046982	protein heterodimerization activity
0.35	GO:0008114	phosphogluconate 2-dehydrogenase activity
0.35	GO:0003777	microtubule motor activity
0.34	GO:0031406	carboxylic acid binding
0.34	GO:0030246	carbohydrate binding
0.34	GO:0050661	NADP binding
0.33	GO:0008017	microtubule binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding

0.38	GO:0071821	FANCM-MHF complex
0.36	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol

0.74

EC:1.1.1.44

GO:0004616

sp|P52272|HNRPM_HUMAN
Heterogeneous nuclear ribonucleoprotein M
Search

HNRNPM

0.91	Heterogeneous nuclear ribonucleoprotein M

0.75	GO:0000398	mRNA splicing, via spliceosome
0.38	GO:0008543	fibroblast growth factor receptor signaling pathway
0.34	GO:1990831	cellular response to carcinoembryonic antigen
0.33	GO:1904591	positive regulation of protein import
0.33	GO:0071222	cellular response to lipopolysaccharide
0.33	GO:1900182	positive regulation of protein localization to nucleus

0.59	GO:0003723	RNA binding
0.50	GO:0019904	protein domain specific binding
0.34	GO:1990405	protein antigen binding
0.33	GO:0048306	calcium-dependent protein binding
0.32	GO:0008270	zinc ion binding

0.60	GO:0019013	viral nucleocapsid
0.56	GO:0042382	paraspeckles
0.56	GO:0030529	intracellular ribonucleoprotein complex
0.53	GO:0016363	nuclear matrix
0.44	GO:1902494	catalytic complex
0.38	GO:0070062	extracellular exosome
0.37	GO:0031012	extracellular matrix
0.36	GO:0005730	nucleolus
0.36	GO:0005887	integral component of plasma membrane
0.33	GO:0009986	cell surface

sp|P52292|IMA1_HUMAN
Importin subunit alpha-1
Search

KPNA2

0.62	Importin subunit alpha

0.79	GO:0006606	protein import into nucleus
0.37	GO:0046015	regulation of transcription by glucose
0.35	GO:0006886	intracellular protein transport
0.35	GO:0000018	regulation of DNA recombination
0.34	GO:0075733	intracellular transport of virus
0.34	GO:0044068	modulation by symbiont of host cellular process
0.34	GO:0019048	modulation by virus of host morphology or physiology
0.33	GO:0006259	DNA metabolic process

0.82	GO:0061608	nuclear import signal receptor activity
0.69	GO:0008565	protein transporter activity
0.56	GO:0008139	nuclear localization sequence binding
0.49	GO:0042826	histone deacetylase binding
0.39	GO:0070491	repressing transcription factor binding
0.34	GO:0003723	RNA binding

0.60	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.47	GO:0031974	membrane-enclosed lumen
0.44	GO:0012505	endomembrane system
0.43	GO:0044446	intracellular organelle part
0.41	GO:0031975	envelope
0.41	GO:0043234	protein complex
0.33	GO:0044216	other organism cell
0.33	GO:0018995	host
0.30	GO:0031224	intrinsic component of membrane

sp|P52294|IMA5_HUMAN
Importin subunit alpha-5
Search

KPNA1

0.60	Importin subunit alpha

0.78	GO:0006606	protein import into nucleus
0.41	GO:0060135	maternal process involved in female pregnancy
0.40	GO:0045944	positive regulation of transcription by RNA polymerase II
0.36	GO:0098926	postsynaptic signal transduction
0.35	GO:0006309	apoptotic DNA fragmentation
0.34	GO:0000018	regulation of DNA recombination
0.34	GO:0075733	intracellular transport of virus
0.34	GO:0044068	modulation by symbiont of host cellular process
0.33	GO:0019048	modulation by virus of host morphology or physiology

0.81	GO:0061608	nuclear import signal receptor activity
0.68	GO:0008565	protein transporter activity
0.48	GO:0008139	nuclear localization sequence binding
0.35	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.51	GO:0005829	cytosol
0.49	GO:0031974	membrane-enclosed lumen
0.44	GO:0044446	intracellular organelle part
0.42	GO:0012505	endomembrane system
0.40	GO:0030425	dendrite
0.40	GO:0031975	envelope
0.40	GO:0043234	protein complex
0.33	GO:0044216	other organism cell
0.33	GO:0018995	host

sp|P52298|NCBP2_HUMAN
Nuclear cap-binding protein subunit 2
Search

NCBP2

0.70	Nuclear cap-binding protein subunit 2

0.83	GO:0045292	mRNA cis splicing, via spliceosome
0.51	GO:0031442	positive regulation of mRNA 3'-end processing
0.51	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.50	GO:0098789	pre-mRNA cleavage required for polyadenylation
0.47	GO:0006446	regulation of translational initiation
0.46	GO:0006408	snRNA export from nucleus
0.45	GO:0046833	positive regulation of RNA export from nucleus
0.43	GO:0031047	gene silencing by RNA
0.42	GO:0051028	mRNA transport
0.37	GO:1900363	regulation of mRNA polyadenylation

0.83	GO:0000339	RNA cap binding
0.51	GO:0017069	snRNA binding
0.48	GO:0003729	mRNA binding
0.33	GO:0005515	protein binding

0.84	GO:0005846	nuclear cap binding complex
0.61	GO:0005634	nucleus
0.50	GO:0005845	mRNA cap binding complex
0.44	GO:0031974	membrane-enclosed lumen
0.40	GO:0044446	intracellular organelle part
0.38	GO:0005737	cytoplasm

sp|P52306|GDS1_HUMAN
Rap1 GTPase-GDP dissociation stimulator 1
Search

RAP1GDS1

0.92	LOW QUALITY PROTEIN: rap1 GTPase-GDP dissociation stimulator 1

0.85	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
0.85	GO:0051561	positive regulation of mitochondrial calcium ion concentration
0.60	GO:0043547	positive regulation of GTPase activity
0.60	GO:0007264	small GTPase mediated signal transduction
0.49	GO:0014829	vascular smooth muscle contraction
0.49	GO:0031034	myosin filament assembly

0.44	GO:0005096	GTPase activator activity
0.43	GO:0017160	Ral GTPase binding

0.68	GO:0005829	cytosol
0.67	GO:0005783	endoplasmic reticulum
0.58	GO:0005739	mitochondrion
0.44	GO:0070062	extracellular exosome
0.39	GO:0005856	cytoskeleton

sp|P52333|JAK3_HUMAN
Tyrosine-protein kinase JAK3
Search

JAK3

0.57	Tyrosine-protein kinase

0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.62	GO:0035556	intracellular signal transduction
0.60	GO:0019221	cytokine-mediated signaling pathway
0.56	GO:0071353	cellular response to interleukin-4
0.54	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.54	GO:0071349	cellular response to interleukin-12
0.52	GO:0071378	cellular response to growth hormone stimulus
0.52	GO:0045785	positive regulation of cell adhesion
0.52	GO:0016572	histone phosphorylation
0.51	GO:0030218	erythrocyte differentiation

0.80	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.62	GO:0042393	histone binding
0.54	GO:0030554	adenyl nucleotide binding
0.54	GO:0019899	enzyme binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0035173	histone kinase activity
0.52	GO:0042169	SH2 domain binding
0.51	GO:0005102	receptor binding

0.68	GO:0005856	cytoskeleton
0.50	GO:0005925	focal adhesion
0.49	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.45	GO:0005654	nucleoplasm
0.37	GO:0005737	cytoplasm
0.34	GO:0016363	nuclear matrix

0.80

GO:0004715

sp|P52429|DGKE_HUMAN
Diacylglycerol kinase epsilon
Search

DGKE

0.47	Diacylglycerol kinase epsilon

0.82	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
0.61	GO:0035556	intracellular signal transduction
0.57	GO:0016310	phosphorylation
0.51	GO:0030258	lipid modification
0.38	GO:2000182	regulation of progesterone biosynthetic process
0.38	GO:2000064	regulation of cortisol biosynthetic process
0.38	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
0.38	GO:0046339	diacylglycerol metabolic process
0.37	GO:0090181	regulation of cholesterol metabolic process
0.37	GO:0070493	thrombin-activated receptor signaling pathway

0.80	GO:0004143	diacylglycerol kinase activity
0.75	GO:0003951	NAD+ kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
0.38	GO:0043274	phospholipase binding
0.37	GO:0033613	activating transcription factor binding
0.36	GO:0019900	kinase binding
0.35	GO:0046872	metal ion binding

0.49	GO:0005829	cytosol
0.46	GO:0005634	nucleus
0.36	GO:0012506	vesicle membrane
0.36	GO:0005768	endosome
0.35	GO:0043233	organelle lumen
0.35	GO:0005856	cytoskeleton
0.34	GO:0005886	plasma membrane
0.34	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

0.80	EC:2.7.1.107	GO:0004143
0.75	KEGG:R00104	GO:0003951

sp|P52434|RPAB3_HUMAN
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Search

POLR2H

0.96	DNA-directed RNA polymerases I, II, and III subunit RPABC3

0.73	GO:0006383	transcription by RNA polymerase III
0.69	GO:0006366	transcription by RNA polymerase II
0.48	GO:0006360	transcription by RNA polymerase I
0.35	GO:0009301	snRNA transcription
0.35	GO:0035019	somatic stem cell population maintenance
0.35	GO:0032481	positive regulation of type I interferon production
0.35	GO:0060964	regulation of gene silencing by miRNA
0.35	GO:0045815	positive regulation of gene expression, epigenetic
0.35	GO:0008543	fibroblast growth factor receptor signaling pathway
0.34	GO:0050434	positive regulation of viral transcription

0.61	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.48	GO:0003697	single-stranded DNA binding

0.76	GO:0005736	DNA-directed RNA polymerase I complex
0.74	GO:0005666	DNA-directed RNA polymerase III complex
0.73	GO:0005665	DNA-directed RNA polymerase II, core complex
0.47	GO:0032993	protein-DNA complex
0.33	GO:0005829	cytosol

0.61

GO:0003899

sp|P52435|RPB11_HUMAN
DNA-directed RNA polymerase II subunit RPB11-a
Search

POLR2J

0.87	DNA-directed RNA polymerase II subunit J

0.74	GO:0006366	transcription by RNA polymerase II
0.36	GO:0009301	snRNA transcription
0.36	GO:0035019	somatic stem cell population maintenance
0.36	GO:0060964	regulation of gene silencing by miRNA
0.35	GO:0008543	fibroblast growth factor receptor signaling pathway
0.35	GO:0050434	positive regulation of viral transcription
0.35	GO:0006283	transcription-coupled nucleotide-excision repair
0.35	GO:0006354	DNA-templated transcription, elongation
0.35	GO:0000398	mRNA splicing, via spliceosome
0.35	GO:0006370	7-methylguanosine mRNA capping

0.82	GO:0001055	RNA polymerase II activity
0.67	GO:0046983	protein dimerization activity
0.52	GO:0003677	DNA binding
0.52	GO:0030275	LRR domain binding

0.79

GO:0005665

DNA-directed RNA polymerase II, core complex

sp|P52564|MP2K6_HUMAN
Dual specificity mitogen-activated protein kinase kinase 6
Search

MAP2K6

0.91	Dual specificity mitogen-activated protein kinase kinase 6

0.63	GO:0006468	protein phosphorylation
0.56	GO:0060048	cardiac muscle contraction
0.55	GO:0000187	activation of MAPK activity
0.47	GO:0031098	stress-activated protein kinase signaling cascade
0.44	GO:0042981	regulation of apoptotic process
0.44	GO:0007346	regulation of mitotic cell cycle
0.42	GO:0072709	cellular response to sorbitol
0.41	GO:0032308	positive regulation of prostaglandin secretion
0.41	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
0.40	GO:0002931	response to ischemia

0.66	GO:0004674	protein serine/threonine kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0019901	protein kinase binding
0.41	GO:0004708	MAP kinase kinase activity
0.37	GO:0004713	protein tyrosine kinase activity
0.37	GO:0042802	identical protein binding

0.48	GO:0005829	cytosol
0.45	GO:0005634	nucleus
0.37	GO:0005856	cytoskeleton
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

0.66

GO:0004674

sp|P52565|GDIR1_HUMAN
Rho GDP-dissociation inhibitor 1
Search

ARHGDIA

0.90	Rho GDP dissociation inhibitor alpha

0.69	GO:0050790	regulation of catalytic activity
0.51	GO:0071526	semaphorin-plexin signaling pathway
0.51	GO:0007266	Rho protein signal transduction
0.47	GO:0032880	regulation of protein localization
0.41	GO:2000249	regulation of actin cytoskeleton reorganization
0.41	GO:0071461	cellular response to redox state
0.40	GO:0030336	negative regulation of cell migration
0.39	GO:0035023	regulation of Rho protein signal transduction
0.39	GO:0044093	positive regulation of molecular function
0.38	GO:1901163	regulation of trophoblast cell migration

0.85	GO:0005094	Rho GDP-dissociation inhibitor activity
0.39	GO:0005096	GTPase activator activity
0.39	GO:0017048	Rho GTPase binding
0.38	GO:0051879	Hsp90 protein binding
0.38	GO:0005504	fatty acid binding
0.37	GO:0019901	protein kinase binding
0.36	GO:0003723	RNA binding
0.35	GO:0003924	GTPase activity

0.52	GO:0001772	immunological synapse
0.49	GO:0005737	cytoplasm
0.42	GO:0005634	nucleus
0.38	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.34	GO:0005856	cytoskeleton
0.33	GO:0097708	intracellular vesicle

sp|P52566|GDIR2_HUMAN
Rho GDP-dissociation inhibitor 2
Search

ARHGDIB

0.89	Rho GDP dissociation inhibitor beta

0.69	GO:0050790	regulation of catalytic activity
0.57	GO:1901164	negative regulation of trophoblast cell migration
0.55	GO:2000249	regulation of actin cytoskeleton reorganization
0.51	GO:0035023	regulation of Rho protein signal transduction
0.46	GO:0071526	semaphorin-plexin signaling pathway
0.46	GO:0007266	Rho protein signal transduction
0.43	GO:0032880	regulation of protein localization
0.42	GO:0071461	cellular response to redox state
0.39	GO:0044093	positive regulation of molecular function
0.36	GO:0007162	negative regulation of cell adhesion

0.85	GO:0005094	Rho GDP-dissociation inhibitor activity
0.54	GO:0048365	Rac GTPase binding
0.46	GO:0003924	GTPase activity
0.39	GO:0005096	GTPase activator activity
0.36	GO:0051879	Hsp90 protein binding
0.36	GO:0005504	fatty acid binding
0.35	GO:0019901	protein kinase binding
0.33	GO:0003723	RNA binding

0.49	GO:0005737	cytoplasm
0.46	GO:0001772	immunological synapse
0.39	GO:0005634	nucleus
0.38	GO:0070062	extracellular exosome
0.34	GO:0005856	cytoskeleton
0.34	GO:0097708	intracellular vesicle

sp|P52569|CTR2_HUMAN
Cationic amino acid transporter 2
Search

SLC7A2

0.93	Low affinity cationic amino acid transporter 2

0.67	GO:0006865	amino acid transport
0.55	GO:0002537	nitric oxide production involved in inflammatory response
0.55	GO:0055085	transmembrane transport
0.53	GO:0043030	regulation of macrophage activation
0.52	GO:0042116	macrophage activation
0.51	GO:0006809	nitric oxide biosynthetic process
0.50	GO:0050727	regulation of inflammatory response
0.47	GO:0098657	import into cell
0.46	GO:0015893	drug transport
0.42	GO:0006812	cation transport

0.57	GO:0022857	transmembrane transporter activity
0.34	GO:0004222	metalloendopeptidase activity
0.32	GO:0046872	metal ion binding

0.48	GO:0030054	cell junction
0.41	GO:0005886	plasma membrane
0.34	GO:0031410	cytoplasmic vesicle
0.33	GO:0005794	Golgi apparatus
0.30	GO:0016021	integral component of membrane

0.34

GO:0004222

sp|P52594|AGFG1_HUMAN
Arf-GAP domain and FG repeat-containing protein 1
Search

AGFG1

0.91	Arf-GAP domain and FG repeats-containing protein 1

0.75	GO:0043547	positive regulation of GTPase activity
0.55	GO:0001675	acrosome assembly
0.54	GO:0045109	intermediate filament organization
0.54	GO:0007289	spermatid nucleus differentiation
0.33	GO:0007275	multicellular organism development
0.32	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.32	GO:0051028	mRNA transport
0.32	GO:0006405	RNA export from nucleus
0.32	GO:0061024	membrane organization
0.31	GO:0010467	gene expression

0.76	GO:0005096	GTPase activator activity
0.47	GO:0046872	metal ion binding
0.32	GO:0003677	DNA binding
0.31	GO:0005515	protein binding
0.31	GO:0003723	RNA binding

0.51	GO:0043025	neuronal cell body
0.48	GO:0031410	cytoplasmic vesicle
0.46	GO:0042995	cell projection
0.41	GO:0043231	intracellular membrane-bounded organelle
0.32	GO:0005829	cytosol
0.32	GO:0012505	endomembrane system
0.31	GO:0031967	organelle envelope
0.31	GO:0043234	protein complex

sp|P52597|HNRPF_HUMAN
Heterogeneous nuclear ribonucleoprotein F
Search

HNRNPH1

0.82	Heterogeneous nuclear ribonucleoprotein F

0.49	GO:0043484	regulation of RNA splicing
0.36	GO:0008380	RNA splicing
0.36	GO:0006397	mRNA processing
0.35	GO:0008543	fibroblast growth factor receptor signaling pathway
0.30	GO:0070671	response to interleukin-12
0.30	GO:0071345	cellular response to cytokine stimulus

0.59	GO:0003723	RNA binding
0.35	GO:0005515	protein binding

0.59	GO:0019013	viral nucleocapsid
0.54	GO:0030529	intracellular ribonucleoprotein complex
0.45	GO:0005654	nucleoplasm
0.45	GO:0005829	cytosol
0.41	GO:1902494	catalytic complex
0.30	GO:0016020	membrane
0.30	GO:0071944	cell periphery

sp|P52630|STAT2_HUMAN
Signal transducer and activator of transcription 2
Search

STAT2

0.69	Signal transducer and activator of transcription

0.60	GO:0007165	signal transduction
0.57	GO:0071345	cellular response to cytokine stimulus
0.57	GO:0006351	transcription, DNA-templated
0.57	GO:0006355	regulation of transcription, DNA-templated
0.55	GO:0034340	response to type I interferon
0.53	GO:0090140	regulation of mitochondrial fission
0.50	GO:0051607	defense response to virus
0.48	GO:1903508	positive regulation of nucleic acid-templated transcription
0.47	GO:0010628	positive regulation of gene expression
0.47	GO:0001932	regulation of protein phosphorylation

0.64	GO:0004871	signal transducer activity
0.61	GO:0003700	DNA binding transcription factor activity
0.54	GO:0003677	DNA binding
0.50	GO:0044389	ubiquitin-like protein ligase binding
0.50	GO:0042802	identical protein binding
0.37	GO:0035035	histone acetyltransferase binding
0.37	GO:1990841	promoter-specific chromatin binding
0.37	GO:0070491	repressing transcription factor binding
0.37	GO:0035257	nuclear hormone receptor binding
0.37	GO:0005164	tumor necrosis factor receptor binding

0.61	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.41	GO:0005886	plasma membrane
0.37	GO:0070013	intracellular organelle lumen
0.35	GO:0000785	chromatin
0.35	GO:0030425	dendrite
0.35	GO:0030424	axon
0.34	GO:0043234	protein complex

sp|P52655|TF2AA_HUMAN
Transcription initiation factor IIA subunit 1
Search

GTF2A1

0.96	Transcription factor IIA large subunit

0.79	GO:0006367	transcription initiation from RNA polymerase II promoter
0.56	GO:0006413	translational initiation
0.39	GO:2001141	regulation of RNA biosynthetic process
0.39	GO:0036465	synaptic vesicle recycling
0.38	GO:0030100	regulation of endocytosis
0.37	GO:0006897	endocytosis
0.36	GO:0042795	snRNA transcription by RNA polymerase II
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0010468	regulation of gene expression
0.35	GO:0006368	transcription elongation from RNA polymerase II promoter

0.57	GO:0001103	RNA polymerase II repressing transcription factor binding
0.56	GO:0003743	translation initiation factor activity
0.54	GO:0017025	TBP-class protein binding
0.50	GO:0046982	protein heterodimerization activity
0.46	GO:0003713	transcription coactivator activity
0.41	GO:0003677	DNA binding

0.83	GO:0005672	transcription factor TFIIA complex
0.53	GO:0005669	transcription factor TFIID complex
0.48	GO:0005829	cytosol
0.38	GO:0098793	presynapse
0.30	GO:0016020	membrane

sp|P52657|T2AG_HUMAN
Transcription initiation factor IIA subunit 2
Search

GTF2A2

0.73	Transcription initiation factor IIA subunit 2

0.79	GO:0006367	transcription initiation from RNA polymerase II promoter
0.59	GO:0006413	translational initiation
0.55	GO:2001141	regulation of RNA biosynthetic process
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.51	GO:0070897	DNA-templated transcriptional preinitiation complex assembly
0.48	GO:0051254	positive regulation of RNA metabolic process
0.48	GO:0010557	positive regulation of macromolecule biosynthetic process
0.48	GO:0031328	positive regulation of cellular biosynthetic process
0.48	GO:0044093	positive regulation of molecular function

0.60	GO:0003743	translation initiation factor activity
0.51	GO:0017025	TBP-class protein binding
0.51	GO:0003713	transcription coactivator activity
0.51	GO:0001103	RNA polymerase II repressing transcription factor binding
0.47	GO:0042803	protein homodimerization activity
0.46	GO:0046982	protein heterodimerization activity
0.34	GO:0001129	RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly
0.34	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.34	GO:0001104	RNA polymerase II transcription cofactor activity

0.83	GO:0005672	transcription factor TFIIA complex
0.48	GO:0005669	transcription factor TFIID complex
0.47	GO:0030054	cell junction

sp|P52701|MSH6_HUMAN
DNA mismatch repair protein Msh6
Search

MSH6

0.83	DNA mismatch repair protein MutS-homolog 6

0.75	GO:0006298	mismatch repair
0.61	GO:0051096	positive regulation of helicase activity
0.59	GO:0016446	somatic hypermutation of immunoglobulin genes
0.58	GO:0002204	somatic recombination of immunoglobulin genes involved in immune response
0.57	GO:0002312	B cell activation involved in immune response
0.57	GO:0045830	positive regulation of isotype switching
0.57	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
0.56	GO:0045910	negative regulation of DNA recombination
0.55	GO:0008340	determination of adult lifespan
0.55	GO:0009411	response to UV

0.76	GO:0030983	mismatched DNA binding
0.61	GO:0032405	MutLalpha complex binding
0.61	GO:0032357	oxidized purine DNA binding
0.59	GO:0000400	four-way junction DNA binding
0.57	GO:0140034	methylation-dependent protein binding
0.55	GO:0042393	histone binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0032301	MutSalpha complex
0.51	GO:0000790	nuclear chromatin
0.51	GO:0005794	Golgi apparatus
0.50	GO:0005654	nucleoplasm
0.49	GO:0005829	cytosol

0.46

GO:0016887

sp|P52732|KIF11_HUMAN
Kinesin-like protein KIF11
Search

KIF11

0.92	Kinesin family member 11

0.74	GO:0007018	microtubule-based movement
0.61	GO:0046602	regulation of mitotic centrosome separation
0.59	GO:0007100	mitotic centrosome separation
0.59	GO:0090307	mitotic spindle assembly
0.45	GO:0007059	chromosome segregation
0.41	GO:0001525	angiogenesis
0.39	GO:0022008	neurogenesis
0.37	GO:0051301	cell division
0.36	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.36	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER

0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.55	GO:0019901	protein kinase binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0032403	protein complex binding
0.42	GO:0042623	ATPase activity, coupled
0.33	GO:0005509	calcium ion binding
0.33	GO:0003677	DNA binding

0.57	GO:0005876	spindle microtubule
0.56	GO:0000922	spindle pole
0.56	GO:0072686	mitotic spindle
0.50	GO:0005829	cytosol
0.48	GO:0005871	kinesin complex
0.35	GO:0005813	centrosome
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|P52735|VAV2_HUMAN
Guanine nucleotide exchange factor VAV2
Search

VAV2

0.91	Vav guanine nucleotide exchange factor 2

0.77	GO:0035023	regulation of Rho protein signal transduction
0.65	GO:0065009	regulation of molecular function
0.62	GO:0035556	intracellular signal transduction
0.53	GO:0030032	lamellipodium assembly
0.52	GO:1903727	positive regulation of phospholipid metabolic process
0.50	GO:0008361	regulation of cell size
0.49	GO:0016477	cell migration
0.48	GO:0042327	positive regulation of phosphorylation
0.38	GO:0050878	regulation of body fluid levels
0.37	GO:0001525	angiogenesis

0.77	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.53	GO:0005154	epidermal growth factor receptor binding
0.52	GO:0001784	phosphotyrosine residue binding
0.52	GO:0046872	metal ion binding
0.33	GO:0016491	oxidoreductase activity

0.45	GO:0005622	intracellular
0.40	GO:0005886	plasma membrane

0.33

GO:0016491

sp|P52736|ZN133_HUMAN
Zinc finger protein 133
Search

0.68	Zinc finger protein 16

0.54	GO:1903506	regulation of nucleic acid-templated transcription
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.43	GO:1902679	negative regulation of RNA biosynthetic process
0.40	GO:0072707	cellular response to sodium dodecyl sulfate
0.39	GO:0045654	positive regulation of megakaryocyte differentiation
0.39	GO:0045648	positive regulation of erythrocyte differentiation
0.38	GO:1901989	positive regulation of cell cycle phase transition
0.37	GO:0008284	positive regulation of cell proliferation
0.37	GO:0033674	positive regulation of kinase activity

0.51	GO:0003676	nucleic acid binding
0.50	GO:0046872	metal ion binding
0.39	GO:0003700	DNA binding transcription factor activity
0.33	GO:0005515	protein binding

0.44	GO:0005622	intracellular
0.38	GO:0043227	membrane-bounded organelle
0.37	GO:0012505	endomembrane system
0.37	GO:0044422	organelle part
0.36	GO:0031975	envelope
0.36	GO:0031974	membrane-enclosed lumen
0.34	GO:0043228	non-membrane-bounded organelle
0.30	GO:0016020	membrane

sp|P52737|ZN136_HUMAN
Zinc finger protein 136
Search

0.73	Zinc finger protein 20

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.39	GO:0006351	transcription, DNA-templated
0.30	GO:0010558	negative regulation of macromolecule biosynthetic process
0.30	GO:0045934	negative regulation of nucleobase-containing compound metabolic process
0.30	GO:0031327	negative regulation of cellular biosynthetic process

0.53	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.34	GO:0005515	protein binding
0.30	GO:0000988	transcription factor activity, protein binding

0.44	GO:0005622	intracellular
0.38	GO:0043227	membrane-bounded organelle

sp|P52738|ZN140_HUMAN
Zinc finger protein 140
Search

ZNF140

0.92	Zinc finger protein 14 homolog

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.51	GO:1902679	negative regulation of RNA biosynthetic process
0.38	GO:0006351	transcription, DNA-templated
0.35	GO:1902680	positive regulation of RNA biosynthetic process
0.34	GO:0043392	negative regulation of DNA binding

0.52	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.44	GO:0003700	DNA binding transcription factor activity
0.34	GO:0005515	protein binding

0.44	GO:0005622	intracellular
0.38	GO:0043227	membrane-bounded organelle
0.35	GO:0017053	transcriptional repressor complex
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044422	organelle part

sp|P52739|ZN131_HUMAN
Zinc finger protein 131
Search

ZNF131

0.65	Zinc finger protein 131

0.69	GO:0006357	regulation of transcription by RNA polymerase II
0.36	GO:0006366	transcription by RNA polymerase II
0.36	GO:0045893	positive regulation of transcription, DNA-templated

0.71	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.50	GO:0003676	nucleic acid binding
0.34	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.50	GO:0045111	intermediate filament cytoskeleton
0.46	GO:0031974	membrane-enclosed lumen
0.42	GO:0044446	intracellular organelle part

sp|P52740|ZN132_HUMAN
Zinc finger protein 132
Search

0.68	Myeloid zinc finger 1

0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.38	GO:0006351	transcription, DNA-templated
0.38	GO:1902679	negative regulation of RNA biosynthetic process
0.37	GO:1902680	positive regulation of RNA biosynthetic process
0.37	GO:0051607	defense response to virus
0.36	GO:0022603	regulation of anatomical structure morphogenesis
0.36	GO:1902466	positive regulation of histone H3-K27 trimethylation
0.36	GO:0007010	cytoskeleton organization

0.51	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.42	GO:0003700	DNA binding transcription factor activity
0.36	GO:0005515	protein binding
0.35	GO:1990841	promoter-specific chromatin binding
0.35	GO:0004672	protein kinase activity
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0032555	purine ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.44	GO:0005622	intracellular
0.38	GO:0043227	membrane-bounded organelle
0.36	GO:0031974	membrane-enclosed lumen
0.34	GO:0043228	non-membrane-bounded organelle
0.34	GO:0044422	organelle part

sp|P52741|ZN134_HUMAN
Zinc finger protein 134
Search

ZNF671

0.73	Zinc finger protein 134

0.52	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.52	GO:1903506	regulation of nucleic acid-templated transcription
0.52	GO:0010468	regulation of gene expression
0.33	GO:0097659	nucleic acid-templated transcription
0.33	GO:0010467	gene expression
0.32	GO:0034645	cellular macromolecule biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.49	GO:0046872	metal ion binding
0.30	GO:0140110	transcription regulator activity

0.42	GO:0005622	intracellular
0.33	GO:0043227	membrane-bounded organelle
0.30	GO:0044425	membrane part

sp|P52742|ZN135_HUMAN
Zinc finger protein 135
Search

0.61	LOW QUALITY PROTEIN: zinc finger protein 135

0.50	GO:1903506	regulation of nucleic acid-templated transcription
0.50	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.49	GO:0010468	regulation of gene expression
0.43	GO:0006351	transcription, DNA-templated
0.37	GO:0007010	cytoskeleton organization
0.37	GO:0022604	regulation of cell morphogenesis
0.35	GO:0006468	protein phosphorylation

0.51	GO:0003676	nucleic acid binding
0.47	GO:0046872	metal ion binding
0.46	GO:0003700	DNA binding transcription factor activity
0.38	GO:0042802	identical protein binding
0.35	GO:0004672	protein kinase activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P52743|ZN137_HUMAN
Putative zinc finger protein 137
Search

0.49	GO:1903506	regulation of nucleic acid-templated transcription
0.49	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.49	GO:0010468	regulation of gene expression
0.47	GO:0044791	positive regulation by host of viral release from host cell
0.37	GO:0006351	transcription, DNA-templated
0.36	GO:0051569	regulation of histone H3-K4 methylation
0.35	GO:0030097	hemopoiesis
0.34	GO:0035556	intracellular signal transduction

0.51	GO:0003676	nucleic acid binding
0.45	GO:0046872	metal ion binding
0.40	GO:0003700	DNA binding transcription factor activity
0.35	GO:0005515	protein binding

0.41

GO:0005634

nucleus

sp|P52744|ZN138_HUMAN
Zinc finger protein 138
Search

ZNF138

0.91	Zinc finger protein 138

0.54	GO:1903506	regulation of nucleic acid-templated transcription
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:0010468	regulation of gene expression
0.40	GO:0006351	transcription, DNA-templated
0.39	GO:1902679	negative regulation of RNA biosynthetic process
0.38	GO:0070895	negative regulation of transposon integration
0.34	GO:0030154	cell differentiation
0.34	GO:0044092	negative regulation of molecular function

0.51	GO:0003676	nucleic acid binding
0.51	GO:0046872	metal ion binding
0.43	GO:0003700	DNA binding transcription factor activity
0.37	GO:0003714	transcription corepressor activity
0.37	GO:0005515	protein binding
0.35	GO:0003682	chromatin binding

0.43	GO:0005634	nucleus
0.34	GO:0043233	organelle lumen
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0044446	intracellular organelle part

sp|P52746|ZN142_HUMAN
Zinc finger protein 142
Search

ZNF142

0.87	Zinc finger protein 142

0.36	GO:0097659	nucleic acid-templated transcription
0.36	GO:1903506	regulation of nucleic acid-templated transcription
0.36	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.36	GO:0010468	regulation of gene expression
0.35	GO:0010467	gene expression
0.35	GO:0034645	cellular macromolecule biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.40	GO:0046872	metal ion binding

0.37

GO:0005634

nucleus

sp|P52747|ZN143_HUMAN
Zinc finger protein 143
Search

0.85	Selenocysteine tRNA activating factor

0.41	GO:0045893	positive regulation of transcription, DNA-templated
0.40	GO:0006366	transcription by RNA polymerase II
0.39	GO:0006357	regulation of transcription by RNA polymerase II
0.34	GO:0006886	intracellular protein transport
0.32	GO:0006359	regulation of transcription by RNA polymerase III
0.30	GO:0016073	snRNA metabolic process
0.30	GO:0098781	ncRNA transcription
0.30	GO:0006383	transcription by RNA polymerase III

0.51	GO:0003676	nucleic acid binding
0.41	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.39	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.36	GO:0046872	metal ion binding
0.35	GO:0008536	Ran GTPase binding

0.38	GO:0005634	nucleus
0.30	GO:0043233	organelle lumen
0.30	GO:0044446	intracellular organelle part

sp|P52756|RBM5_HUMAN
RNA-binding protein 5
Search

RBM5

0.91	RNA binding motif protein 5

0.84	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.74	GO:0042981	regulation of apoptotic process
0.73	GO:0008380	RNA splicing
0.58	GO:0043068	positive regulation of programmed cell death
0.55	GO:0022618	ribonucleoprotein complex assembly
0.53	GO:0006397	mRNA processing
0.41	GO:0006915	apoptotic process
0.36	GO:0008285	negative regulation of cell proliferation
0.32	GO:0007015	actin filament organization

0.59	GO:0003723	RNA binding
0.52	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding
0.33	GO:0003677	DNA binding
0.32	GO:0044877	macromolecular complex binding

0.76	GO:0005681	spliceosomal complex
0.53	GO:0005654	nucleoplasm
0.32	GO:0031209	SCAR complex
0.30	GO:0031224	intrinsic component of membrane

sp|P52757|CHIO_HUMAN
Beta-chimaerin
Search

CHN2

0.94	Beta-chimaerin

0.74	GO:0043547	positive regulation of GTPase activity
0.69	GO:0051056	regulation of small GTPase mediated signal transduction
0.62	GO:0035556	intracellular signal transduction
0.42	GO:0008045	motor neuron axon guidance
0.41	GO:0050770	regulation of axonogenesis
0.34	GO:0001675	acrosome assembly
0.34	GO:0009967	positive regulation of signal transduction

0.74	GO:0005096	GTPase activator activity
0.53	GO:0046872	metal ion binding
0.42	GO:0046875	ephrin receptor binding
0.35	GO:0005070	SH3/SH2 adaptor activity
0.35	GO:0001565	phorbol ester receptor activity

0.45	GO:0005622	intracellular
0.33	GO:0045202	synapse
0.30	GO:0016020	membrane

sp|P52758|UK114_HUMAN
Ribonuclease UK114
Search

0.65	Reactive intermediate imine deaminase A homolog

0.62	GO:1901565	organonitrogen compound catabolic process
0.56	GO:0070314	G1 to G0 transition
0.55	GO:1902074	response to salt
0.53	GO:0017148	negative regulation of translation
0.52	GO:0050680	negative regulation of epithelial cell proliferation
0.52	GO:0030324	lung development
0.51	GO:0001822	kidney development
0.50	GO:0007420	brain development
0.50	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.49	GO:0033993	response to lipid

0.70	GO:0019239	deaminase activity
0.59	GO:1904012	platinum binding
0.59	GO:1904013	xenon atom binding
0.55	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters
0.55	GO:0036041	long-chain fatty acid binding
0.49	GO:0042803	protein homodimerization activity
0.43	GO:0046914	transition metal ion binding
0.39	GO:0003723	RNA binding

0.59	GO:0005634	nucleus
0.57	GO:0005739	mitochondrion
0.53	GO:0005777	peroxisome
0.49	GO:0031974	membrane-enclosed lumen
0.46	GO:0005829	cytosol
0.45	GO:0070062	extracellular exosome
0.44	GO:0044446	intracellular organelle part

0.55

EC:3.1.27

GO:0016892

sp|P52788|SPSY_HUMAN
Spermine synthase
Search

SMS

0.72	LOW QUALITY PROTEIN: spermine synthase

0.83	GO:0006597	spermine biosynthetic process
0.34	GO:0006555	methionine metabolic process
0.33	GO:0006412	translation

0.85	GO:0016768	spermine synthase activity
0.33	GO:0003735	structural constituent of ribosome

0.37	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol
0.33	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.85

EC:2.5.1.22

GO:0016768

sp|P52789|HXK2_HUMAN
Hexokinase-2
Search

0.32	Phosphotransferase

0.82	GO:0001678	cellular glucose homeostasis
0.74	GO:0046835	carbohydrate phosphorylation
0.71	GO:0006757	ATP generation from ADP
0.69	GO:0006090	pyruvate metabolic process
0.68	GO:0016052	carbohydrate catabolic process
0.67	GO:0019362	pyridine nucleotide metabolic process
0.30	GO:0050878	regulation of body fluid levels
0.30	GO:0019222	regulation of metabolic process
0.30	GO:0008104	protein localization
0.30	GO:0010827	regulation of glucose transport

0.83	GO:0005536	glucose binding
0.79	GO:0004396	hexokinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.30	GO:0005515	protein binding

0.30	GO:0043227	membrane-bounded organelle
0.30	GO:0016020	membrane
0.30	GO:0044464	cell part
0.30	GO:0044422	organelle part

0.79

EC:2.7.1.1

GO:0004396

sp|P52790|HXK3_HUMAN
Hexokinase-3
Search

0.62	Hexokinase 3

0.82	GO:0001678	cellular glucose homeostasis
0.74	GO:0046835	carbohydrate phosphorylation
0.69	GO:0006757	ATP generation from ADP
0.67	GO:0006090	pyruvate metabolic process
0.66	GO:0016052	carbohydrate catabolic process
0.66	GO:0019362	pyridine nucleotide metabolic process
0.46	GO:0051156	glucose 6-phosphate metabolic process
0.30	GO:0002366	leukocyte activation involved in immune response
0.30	GO:0002443	leukocyte mediated immunity
0.30	GO:0005996	monosaccharide metabolic process

0.83	GO:0005536	glucose binding
0.79	GO:0004396	hexokinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0005829	cytosol
0.41	GO:0005739	mitochondrion
0.30	GO:0044433	cytoplasmic vesicle part
0.30	GO:0005576	extracellular region
0.30	GO:0043233	organelle lumen
0.30	GO:0101002	ficolin-1-rich granule

0.79

EC:2.7.1.1

GO:0004396

sp|P52797|EFNA3_HUMAN
Ephrin-A3
Search

0.83	GO:0048013	ephrin receptor signaling pathway
0.49	GO:1905247	positive regulation of aspartic-type peptidase activity
0.49	GO:1902959	regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
0.49	GO:0007411	axon guidance
0.49	GO:1902993	positive regulation of amyloid precursor protein catabolic process
0.47	GO:0016525	negative regulation of angiogenesis
0.47	GO:0010950	positive regulation of endopeptidase activity
0.43	GO:0030316	osteoclast differentiation
0.43	GO:0046849	bone remodeling
0.39	GO:0045664	regulation of neuron differentiation

0.85	GO:0046875	ephrin receptor binding
0.37	GO:0005005	transmembrane-ephrin receptor activity
0.32	GO:0004222	metalloendopeptidase activity
0.32	GO:0003723	RNA binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.40	GO:0005886	plasma membrane
0.39	GO:0031225	anchored component of membrane
0.36	GO:0043204	perikaryon
0.36	GO:0031594	neuromuscular junction
0.30	GO:0016021	integral component of membrane

0.32

GO:0004222

sp|P52798|EFNA4_HUMAN
Ephrin-A4
Search

0.82	GO:0048013	ephrin receptor signaling pathway
0.50	GO:0030316	osteoclast differentiation
0.50	GO:0046849	bone remodeling
0.49	GO:0007411	axon guidance
0.37	GO:0048668	collateral sprouting
0.36	GO:0010771	negative regulation of cell morphogenesis involved in differentiation
0.36	GO:0071372	cellular response to follicle-stimulating hormone stimulus
0.36	GO:0001525	angiogenesis
0.36	GO:0050807	regulation of synapse organization
0.36	GO:0050730	regulation of peptidyl-tyrosine phosphorylation

0.84	GO:0046875	ephrin receptor binding
0.37	GO:0005005	transmembrane-ephrin receptor activity
0.36	GO:0005169	neurotrophin TRKB receptor binding
0.36	GO:0045499	chemorepellent activity
0.35	GO:0004222	metalloendopeptidase activity
0.33	GO:0046872	metal ion binding
0.32	GO:0003723	RNA binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0032555	purine ribonucleotide binding

0.41	GO:0031225	anchored component of membrane
0.40	GO:0005886	plasma membrane
0.35	GO:0005576	extracellular region
0.35	GO:0005912	adherens junction
0.35	GO:0009986	cell surface
0.34	GO:0098552	side of membrane
0.30	GO:0016021	integral component of membrane

0.35

GO:0004222

sp|P52799|EFNB2_HUMAN
Ephrin-B2
Search

0.78	GO:0048013	ephrin receptor signaling pathway
0.59	GO:0002042	cell migration involved in sprouting angiogenesis
0.58	GO:1903849	positive regulation of aorta morphogenesis
0.57	GO:0031295	T cell costimulation
0.57	GO:1901216	positive regulation of neuron death
0.56	GO:0048845	venous blood vessel morphogenesis
0.56	GO:0010977	negative regulation of neuron projection development
0.56	GO:0010839	negative regulation of keratinocyte proliferation
0.56	GO:0072178	nephric duct morphogenesis
0.55	GO:2000727	positive regulation of cardiac muscle cell differentiation

0.80	GO:0046875	ephrin receptor binding
0.35	GO:0104005	hijacked molecular function
0.33	GO:0016301	kinase activity

0.44	GO:0005886	plasma membrane
0.38	GO:0045121	membrane raft
0.36	GO:0005925	focal adhesion
0.35	GO:0005634	nucleus
0.33	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|P52803|EFNA5_HUMAN
Ephrin-A5
Search

0.92	Putative ephrin ligand for eph receptor tyrosine kinase

0.83	GO:0048013	ephrin receptor signaling pathway
0.57	GO:0071372	cellular response to follicle-stimulating hormone stimulus
0.56	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
0.56	GO:0048672	positive regulation of collateral sprouting
0.56	GO:0048668	collateral sprouting
0.56	GO:1904321	response to forskolin
0.56	GO:0090109	regulation of cell-substrate junction assembly
0.56	GO:1903391	regulation of adherens junction organization
0.55	GO:0031290	retinal ganglion cell axon guidance
0.55	GO:0050919	negative chemotaxis

0.85	GO:0046875	ephrin receptor binding
0.58	GO:0005169	neurotrophin TRKB receptor binding
0.57	GO:0045499	chemorepellent activity
0.37	GO:0005170	neurotrophin TRKC receptor binding
0.36	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
0.36	GO:0005168	neurotrophin TRKA receptor binding
0.35	GO:0016301	kinase activity
0.34	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
0.33	GO:0008168	methyltransferase activity

0.57	GO:0031362	anchored component of external side of plasma membrane
0.52	GO:0005604	basement membrane
0.51	GO:0005912	adherens junction
0.38	GO:0005901	caveola
0.30	GO:0016021	integral component of membrane

0.34

EC:1.14.11

GO:0016706

sp|P52815|RM12_HUMAN
39S ribosomal protein L12, mitochondrial
Search

MRPL12

0.92	Mitochondrial ribosomal protein L12

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.51	GO:0000959	mitochondrial RNA metabolic process
0.47	GO:0045893	positive regulation of transcription, DNA-templated
0.46	GO:0006839	mitochondrial transport
0.41	GO:1902356	oxaloacetate(2-) transmembrane transport
0.41	GO:0071422	succinate transmembrane transport
0.41	GO:0071423	malate transmembrane transport

0.64	GO:0003735	structural constituent of ribosome
0.41	GO:0015131	oxaloacetate transmembrane transporter activity
0.41	GO:0015141	succinate transmembrane transporter activity
0.41	GO:0015140	malate transmembrane transporter activity
0.40	GO:0015117	thiosulfate transmembrane transporter activity
0.38	GO:0015116	sulfate transmembrane transporter activity
0.38	GO:0015297	antiporter activity
0.37	GO:0000095	S-adenosyl-L-methionine transmembrane transporter activity
0.36	GO:0004967	glucagon receptor activity
0.35	GO:0016301	kinase activity

0.61	GO:0005840	ribosome
0.50	GO:0005759	mitochondrial matrix
0.42	GO:0031966	mitochondrial membrane
0.39	GO:0019866	organelle inner membrane
0.37	GO:0005654	nucleoplasm
0.33	GO:0009295	nucleoid
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P52823|STC1_HUMAN
Stanniocalcin-1
Search

STC1

0.97	Stanniocalcin

0.76	GO:0010469	regulation of receptor activity
0.63	GO:0003421	growth plate cartilage axis specification
0.63	GO:1903403	negative regulation of renal phosphate excretion
0.61	GO:0001886	endothelial cell morphogenesis
0.60	GO:0035988	chondrocyte proliferation
0.60	GO:0090280	positive regulation of calcium ion import
0.59	GO:0086004	regulation of cardiac muscle cell contraction
0.59	GO:0010596	negative regulation of endothelial cell migration
0.58	GO:0051926	negative regulation of calcium ion transport
0.58	GO:0044070	regulation of anion transport

0.79	GO:0005179	hormone activity
0.33	GO:0043565	sequence-specific DNA binding

0.66	GO:0005576	extracellular region
0.46	GO:0005634	nucleus
0.40	GO:0005737	cytoplasm
0.39	GO:0016324	apical plasma membrane
0.33	GO:0097708	intracellular vesicle
0.33	GO:0012505	endomembrane system

sp|P52824|DGKQ_HUMAN
Diacylglycerol kinase theta
Search

DGKQ

0.49	Diacylglycerol kinase theta

0.82	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
0.60	GO:0035556	intracellular signal transduction
0.59	GO:2000182	regulation of progesterone biosynthetic process
0.58	GO:2000064	regulation of cortisol biosynthetic process
0.58	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
0.57	GO:0016310	phosphorylation
0.57	GO:0046339	diacylglycerol metabolic process
0.57	GO:0090181	regulation of cholesterol metabolic process
0.56	GO:0070493	thrombin-activated receptor signaling pathway
0.56	GO:0051591	response to cAMP

0.80	GO:0004143	diacylglycerol kinase activity
0.75	GO:0003951	NAD+ kinase activity
0.58	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
0.58	GO:0043274	phospholipase binding
0.55	GO:0033613	activating transcription factor binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0019900	kinase binding
0.44	GO:0046872	metal ion binding

0.53	GO:0016607	nuclear speck
0.51	GO:0012506	vesicle membrane
0.51	GO:0005768	endosome
0.48	GO:0005856	cytoskeleton
0.47	GO:0005829	cytosol
0.42	GO:0005886	plasma membrane
0.41	GO:0016363	nuclear matrix
0.30	GO:0031224	intrinsic component of membrane

0.80	EC:2.7.1.107	GO:0004143
0.75	KEGG:R00104	GO:0003951

sp|P52848|NDST1_HUMAN
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
Search

NDST1

0.96	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

0.56	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
0.56	GO:0048702	embryonic neurocranium morphogenesis
0.55	GO:0007585	respiratory gaseous exchange
0.55	GO:0045880	positive regulation of smoothened signaling pathway
0.55	GO:0060976	coronary vasculature development
0.55	GO:0048703	embryonic viscerocranium morphogenesis
0.54	GO:0035904	aorta development
0.54	GO:0030901	midbrain development
0.54	GO:0003279	cardiac septum development
0.53	GO:0008543	fibroblast growth factor receptor signaling pathway

0.86	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity
0.58	GO:0042328	heparan sulfate N-acetylglucosaminyltransferase activity
0.51	GO:0016787	hydrolase activity
0.34	GO:0005515	protein binding

0.38	GO:0000139	Golgi membrane
0.30	GO:0016021	integral component of membrane

0.86

EC:2.8.2.8

GO:0015016

sp|P52849|NDST2_HUMAN
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Search

NDST2

0.97	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

0.50	GO:0015012	heparan sulfate proteoglycan biosynthetic process
0.49	GO:0048702	embryonic neurocranium morphogenesis
0.48	GO:0007585	respiratory gaseous exchange
0.48	GO:0045880	positive regulation of smoothened signaling pathway
0.48	GO:0060976	coronary vasculature development
0.48	GO:0048703	embryonic viscerocranium morphogenesis
0.48	GO:0035904	aorta development
0.48	GO:0030901	midbrain development
0.47	GO:0003279	cardiac septum development
0.47	GO:0008543	fibroblast growth factor receptor signaling pathway

0.85	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity
0.51	GO:0016787	hydrolase activity
0.50	GO:0042328	heparan sulfate N-acetylglucosaminyltransferase activity
0.34	GO:0005515	protein binding

0.39	GO:0005794	Golgi apparatus
0.38	GO:0098588	bounding membrane of organelle
0.37	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.85

EC:2.8.2.8

GO:0015016

sp|P52888|THOP1_HUMAN
Thimet oligopeptidase
Search

THOP1

0.90	Thimet oligopeptidase

0.57	GO:0006508	proteolysis
0.39	GO:0006518	peptide metabolic process
0.35	GO:0000209	protein polyubiquitination
0.34	GO:0035556	intracellular signal transduction

0.65	GO:0004222	metalloendopeptidase activity
0.51	GO:0046872	metal ion binding
0.37	GO:0042277	peptide binding
0.35	GO:0005515	protein binding

0.45	GO:0005758	mitochondrial intermembrane space
0.34	GO:0005829	cytosol

0.65

GO:0004222

sp|P52895|AK1C2_HUMAN
Aldo-keto reductase family 1 member C2
Search

0.96	3-hydroxyhexobarbital dehydrogenase

0.53	GO:0055114	oxidation-reduction process
0.51	GO:0044597	daunorubicin metabolic process
0.49	GO:0071395	cellular response to jasmonic acid stimulus
0.48	GO:0044598	doxorubicin metabolic process
0.47	GO:0008202	steroid metabolic process
0.45	GO:0071798	response to prostaglandin D
0.45	GO:1900053	negative regulation of retinoic acid biosynthetic process
0.44	GO:0016488	farnesol catabolic process
0.44	GO:0071379	cellular response to prostaglandin stimulus
0.44	GO:2000224	regulation of testosterone biosynthetic process

0.54	GO:0016491	oxidoreductase activity
0.43	GO:0032052	bile acid binding
0.37	GO:0005496	steroid binding
0.36	GO:0070401	NADP+ binding
0.36	GO:0070402	NADPH binding
0.35	GO:0015125	bile acid transmembrane transporter activity
0.34	GO:0004452	isopentenyl-diphosphate delta-isomerase activity
0.33	GO:0005515	protein binding
0.32	GO:0016787	hydrolase activity

0.39	GO:0005829	cytosol
0.39	GO:0070062	extracellular exosome
0.38	GO:0005634	nucleus

0.54	EC:1	GO:0016491
0.34	KEGG:R01123	GO:0004452

sp|P52907|CAZA1_HUMAN
F-actin-capping protein subunit alpha-1
Search

CAPZA1

0.94	Capping actin protein of muscle Z-line alpha subunit 1

0.84	GO:0051016	barbed-end actin filament capping
0.51	GO:0034329	cell junction assembly
0.36	GO:0050878	regulation of body fluid levels
0.35	GO:0035722	interleukin-12-mediated signaling pathway
0.35	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.35	GO:0070495	negative regulation of thrombin-activated receptor signaling pathway
0.35	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity
0.35	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
0.35	GO:0001886	endothelial cell morphogenesis
0.35	GO:2001028	positive regulation of endothelial cell chemotaxis

0.74	GO:0003779	actin binding
0.50	GO:0045296	cadherin binding
0.35	GO:0032403	protein complex binding
0.34	GO:0019903	protein phosphatase binding
0.34	GO:0004713	protein tyrosine kinase activity
0.33	GO:0042802	identical protein binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0008144	drug binding

0.84	GO:0008290	F-actin capping protein complex
0.52	GO:0071203	WASH complex
0.45	GO:0005903	brush border
0.44	GO:0030863	cortical cytoskeleton
0.38	GO:0030018	Z disc
0.36	GO:0070062	extracellular exosome
0.35	GO:0005911	cell-cell junction
0.34	GO:0009925	basal plasma membrane
0.34	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.34

GO:0004713

sp|P52926|HMGA2_HUMAN
High mobility group protein HMGI-C
Search

HMGA2

0.96	High mobility group protein HMGI-C

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:0090402	oncogene-induced cell senescence
0.53	GO:0035986	senescence-associated heterochromatin focus assembly
0.52	GO:2000774	positive regulation of cellular senescence
0.48	GO:0031052	chromosome breakage
0.48	GO:0035978	histone H2A-S139 phosphorylation
0.48	GO:0003131	mesodermal-endodermal cell signaling
0.47	GO:2000685	positive regulation of cellular response to X-ray

0.54	GO:0003677	DNA binding
0.48	GO:0035501	MH1 domain binding
0.48	GO:0051575	5'-deoxyribose-5-phosphate lyase activity
0.48	GO:0035500	MH2 domain binding
0.46	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
0.46	GO:0070742	C2H2 zinc finger domain binding
0.46	GO:0001067	regulatory region nucleic acid binding
0.46	GO:0004677	DNA-dependent protein kinase activity
0.45	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.45	GO:0042975	peroxisome proliferator activated receptor binding

0.71	GO:0000785	chromatin
0.61	GO:0005634	nucleus
0.46	GO:0071141	SMAD protein complex
0.41	GO:0032993	protein-DNA complex
0.41	GO:0070013	intracellular organelle lumen
0.36	GO:0005667	transcription factor complex
0.34	GO:0005925	focal adhesion
0.32	GO:0005829	cytosol

0.46	EC:4.2.99.18	GO:0003906
0.32	KEGG:R03876	GO:0004842

sp|P52943|CRIP2_HUMAN
Cysteine-rich protein 2
Search

0.56	Cysteine-rich protein 3

0.42	GO:0030097	hemopoiesis
0.42	GO:0008284	positive regulation of cell proliferation

0.54	GO:0046872	metal ion binding
0.42	GO:0046982	protein heterodimerization activity
0.37	GO:0003677	DNA binding

0.42	GO:0000786	nucleosome
0.41	GO:0005938	cell cortex
0.41	GO:0031012	extracellular matrix
0.38	GO:0005634	nucleus

sp|P52945|PDX1_HUMAN
Pancreas/duodenum homeobox protein 1
Search

PDX1

0.97	Pancreatic and duodenal homeobox

0.60	GO:0031018	endocrine pancreas development
0.59	GO:2000675	negative regulation of type B pancreatic cell apoptotic process
0.59	GO:0007263	nitric oxide mediated signal transduction
0.58	GO:0001889	liver development
0.58	GO:0035883	enteroendocrine cell differentiation
0.58	GO:0030073	insulin secretion
0.58	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.58	GO:0031017	exocrine pancreas development
0.58	GO:0048565	digestive tract development
0.57	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus

0.64	GO:0043565	sequence-specific DNA binding
0.57	GO:0003700	DNA binding transcription factor activity
0.54	GO:0001012	RNA polymerase II regulatory region DNA binding
0.52	GO:0003682	chromatin binding
0.51	GO:0003690	double-stranded DNA binding
0.40	GO:0008134	transcription factor binding
0.36	GO:0032403	protein complex binding
0.36	GO:0046982	protein heterodimerization activity

0.61	GO:0005634	nucleus
0.50	GO:0070013	intracellular organelle lumen
0.45	GO:0044446	intracellular organelle part
0.40	GO:0005829	cytosol
0.38	GO:0012505	endomembrane system
0.36	GO:0031090	organelle membrane
0.36	GO:0031975	envelope
0.35	GO:0030054	cell junction
0.30	GO:0016021	integral component of membrane

sp|P52948|NUP98_HUMAN
Nuclear pore complex protein Nup98-Nup96
Search

NUP98

0.80	Nuclear pore complex protein Nup98-Nup96

0.72	GO:0006913	nucleocytoplasmic transport
0.51	GO:0048026	positive regulation of mRNA splicing, via spliceosome
0.51	GO:0051292	nuclear pore complex assembly
0.46	GO:0006366	transcription by RNA polymerase II
0.46	GO:0045944	positive regulation of transcription by RNA polymerase II
0.43	GO:0000973	posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
0.43	GO:0034398	telomere tethering at nuclear periphery
0.43	GO:0006260	DNA replication
0.42	GO:0051236	establishment of RNA localization
0.42	GO:0050657	nucleic acid transport

0.80	GO:0017056	structural constituent of nuclear pore
0.51	GO:1990841	promoter-specific chromatin binding
0.50	GO:0001105	RNA polymerase II transcription coactivator activity
0.46	GO:0003729	mRNA binding
0.43	GO:0008139	nuclear localization sequence binding
0.33	GO:0005230	extracellular ligand-gated ion channel activity
0.33	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
0.33	GO:0022835	transmitter-gated channel activity
0.33	GO:0140135	mechanosensitive cation channel activity
0.32	GO:0018024	histone-lysine N-methyltransferase activity

0.78	GO:0005643	nuclear pore
0.51	GO:0042405	nuclear inclusion body
0.48	GO:0034399	nuclear periphery
0.48	GO:0031965	nuclear membrane
0.47	GO:0000776	kinetochore
0.47	GO:0016604	nuclear body
0.41	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0045211	postsynaptic membrane
0.32	GO:0030054	cell junction
0.31	GO:0005829	cytosol

0.32

EC:2.1.1.43

GO:0018024

sp|P52951|GBX2_HUMAN
Homeobox protein GBX-2
Search

GBX2

0.96	Gastrulation brain homeo box 2

0.62	GO:0021568	rhombomere 2 development
0.61	GO:0021555	midbrain-hindbrain boundary morphogenesis
0.60	GO:0021930	cerebellar granule cell precursor proliferation
0.59	GO:0021794	thalamus development
0.59	GO:0021953	central nervous system neuron differentiation
0.59	GO:0021549	cerebellum development
0.58	GO:0001569	branching involved in blood vessel morphogenesis
0.58	GO:0007411	axon guidance
0.57	GO:0001755	neural crest cell migration
0.57	GO:0021872	forebrain generation of neurons

0.64	GO:0043565	sequence-specific DNA binding
0.57	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.56	GO:0001047	core promoter binding
0.55	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.53	GO:0001012	RNA polymerase II regulatory region DNA binding
0.50	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|P52952|NKX25_HUMAN
Homeobox protein Nkx-2.5
Search

NKX2-5

0.96	Cardiac homeobox transcription factor

0.80	GO:1903779	regulation of cardiac conduction
0.78	GO:0060048	cardiac muscle contraction
0.74	GO:0007507	heart development
0.66	GO:0006357	regulation of transcription by RNA polymerase II
0.64	GO:0060037	pharyngeal system development
0.64	GO:0048536	spleen development
0.63	GO:0014855	striated muscle cell proliferation
0.63	GO:0014706	striated muscle tissue development
0.62	GO:0010667	negative regulation of cardiac muscle cell apoptotic process
0.61	GO:0010832	negative regulation of myotube differentiation

0.64	GO:0043565	sequence-specific DNA binding
0.58	GO:0003700	DNA binding transcription factor activity
0.57	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.56	GO:0001012	RNA polymerase II regulatory region DNA binding
0.55	GO:0003682	chromatin binding
0.54	GO:0001104	RNA polymerase II transcription cofactor activity
0.53	GO:0003690	double-stranded DNA binding
0.52	GO:0008134	transcription factor binding
0.52	GO:0042803	protein homodimerization activity
0.52	GO:0046982	protein heterodimerization activity

0.61	GO:0005634	nucleus
0.54	GO:0005667	transcription factor complex
0.52	GO:0032993	protein-DNA complex
0.44	GO:0044446	intracellular organelle part
0.39	GO:0005737	cytoplasm
0.33	GO:0005576	extracellular region
0.30	GO:0016020	membrane

sp|P52954|LBX1_HUMAN
Transcription factor LBX1
Search

LBX1

0.97	Ladybird homeobox 1 transcription factor

0.61	GO:0021920	regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification
0.59	GO:0048664	neuron fate determination
0.57	GO:0021522	spinal cord motor neuron differentiation
0.56	GO:0001947	heart looping
0.55	GO:0045665	negative regulation of neuron differentiation
0.53	GO:0008285	negative regulation of cell proliferation
0.46	GO:0061061	muscle structure development
0.41	GO:0048468	cell development
0.38	GO:0051450	myoblast proliferation
0.36	GO:0060026	convergent extension

0.64	GO:0043565	sequence-specific DNA binding
0.45	GO:0003700	DNA binding transcription factor activity
0.34	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.52	GO:0005667	transcription factor complex
0.30	GO:0016021	integral component of membrane

sp|P52961|NAR1_HUMAN
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
Search

ART1

0.73	Erythroblast NAD(P)(+)--arginine ADP-ribosyltransferase

0.84	GO:0006471	protein ADP-ribosylation
0.34	GO:0046677	response to antibiotic
0.34	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.34	GO:0007186	G-protein coupled receptor signaling pathway

0.85	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity
0.60	GO:0003950	NAD+ ADP-ribosyltransferase activity
0.34	GO:0004984	olfactory receptor activity
0.33	GO:0016787	hydrolase activity

0.59	GO:0031225	anchored component of membrane
0.56	GO:0009986	cell surface
0.42	GO:0033017	sarcoplasmic reticulum membrane
0.36	GO:0044194	cytolytic granule
0.35	GO:0005887	integral component of plasma membrane
0.34	GO:0005615	extracellular space

0.85

EC:2.4.2.31

GO:0003956

sp|P53004|BIEA_HUMAN
Biliverdin reductase A
Search

BLVRA

0.97	Biliverdin reductase A

0.85	GO:0042167	heme catabolic process
0.52	GO:0055114	oxidation-reduction process

0.86	GO:0004074	biliverdin reductase activity
0.62	GO:0008270	zinc ion binding
0.36	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity
0.34	GO:0005515	protein binding
0.33	GO:1901265	nucleoside phosphate binding
0.32	GO:0036094	small molecule binding
0.32	GO:0033712	1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity

0.48	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.86	EC:1.3.1.24	GO:0004074
0.36	KEGG:R02082	GO:0004420

sp|P53007|TXTP_HUMAN
Tricarboxylate transport protein, mitochondrial
Search

SLC25A1

0.48	Plasma membrane citrate carrier

0.51	GO:0006843	mitochondrial citrate transport
0.49	GO:0055085	transmembrane transport
0.40	GO:0010821	regulation of mitochondrion organization
0.39	GO:0048268	clathrin coat assembly
0.37	GO:0006886	intracellular protein transport
0.37	GO:0016192	vesicle-mediated transport
0.37	GO:0046326	positive regulation of glucose import
0.36	GO:0016482	cytosolic transport
0.36	GO:0016197	endosomal transport
0.35	GO:0000278	mitotic cell cycle

0.48	GO:0015137	citrate transmembrane transporter activity
0.39	GO:0032051	clathrin light chain binding
0.36	GO:0005198	structural molecule activity

0.44	GO:0031090	organelle membrane
0.43	GO:0044429	mitochondrial part
0.43	GO:0031967	organelle envelope
0.39	GO:0071439	clathrin complex
0.39	GO:0030140	trans-Golgi network transport vesicle
0.39	GO:0030132	clathrin coat of coated pit
0.38	GO:0044433	cytoplasmic vesicle part
0.37	GO:0044431	Golgi apparatus part
0.37	GO:0097443	sorting endosome
0.36	GO:0070062	extracellular exosome

sp|P53041|PPP5_HUMAN
Serine/threonine-protein phosphatase 5
Search

PPP5C

0.54	Serine/threonine-protein phosphatase

0.69	GO:0006470	protein dephosphorylation
0.55	GO:0043278	response to morphine
0.42	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway
0.41	GO:0010288	response to lead ion
0.40	GO:0071276	cellular response to cadmium ion
0.40	GO:0051291	protein heterooligomerization
0.40	GO:0070301	cellular response to hydrogen peroxide
0.40	GO:1901215	negative regulation of neuron death
0.38	GO:0001933	negative regulation of protein phosphorylation
0.38	GO:0016570	histone modification

0.69	GO:0004721	phosphoprotein phosphatase activity
0.54	GO:0051879	Hsp90 protein binding
0.49	GO:0043531	ADP binding
0.48	GO:0042802	identical protein binding
0.42	GO:0003723	RNA binding
0.41	GO:0005524	ATP binding
0.40	GO:0001965	G-protein alpha-subunit binding
0.38	GO:0008017	microtubule binding
0.35	GO:0004871	signal transducer activity
0.34	GO:0008289	lipid binding

0.47	GO:0005829	cytosol
0.42	GO:0043234	protein complex
0.42	GO:1990635	proximal dendrite
0.41	GO:0043227	membrane-bounded organelle
0.40	GO:0043204	perikaryon
0.40	GO:0043229	intracellular organelle
0.35	GO:0071944	cell periphery
0.34	GO:0072357	PTW/PP1 phosphatase complex
0.34	GO:0000164	protein phosphatase type 1 complex
0.34	GO:0043233	organelle lumen

0.69

EC:3.1.3.16

GO:0004721

sp|P53350|PLK1_HUMAN
Serine/threonine-protein kinase PLK1
Search

PLK1

0.76	Serine/threonine-protein kinase PLK

0.61	GO:0006468	protein phosphorylation
0.59	GO:0051081	nuclear envelope disassembly
0.58	GO:0070194	synaptonemal complex disassembly
0.58	GO:0090435	protein localization to nuclear envelope
0.58	GO:0072425	signal transduction involved in G2 DNA damage checkpoint
0.57	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
0.57	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
0.57	GO:1901673	regulation of mitotic spindle assembly
0.57	GO:0071168	protein localization to chromatin
0.57	GO:0016321	female meiosis chromosome segregation

0.67	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0010997	anaphase-promoting complex binding
0.53	GO:0030554	adenyl nucleotide binding
0.53	GO:0019901	protein kinase binding
0.52	GO:0097367	carbohydrate derivative binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0008144	drug binding
0.51	GO:0008017	microtubule binding
0.50	GO:0042802	identical protein binding
0.46	GO:0000287	magnesium ion binding

0.55	GO:0051233	spindle midzone
0.55	GO:0030496	midbody
0.55	GO:0000795	synaptonemal complex
0.54	GO:0005876	spindle microtubule
0.54	GO:0000942	condensed nuclear chromosome outer kinetochore
0.53	GO:0000922	spindle pole
0.52	GO:0005813	centrosome
0.49	GO:0000785	chromatin
0.30	GO:0016020	membrane

0.67

GO:0004674

sp|P53355|DAPK1_HUMAN
Death-associated protein kinase 1
Search

DAPK1

0.91	Death-associated protein kinase

0.76	GO:0006915	apoptotic process
0.62	GO:0006468	protein phosphorylation
0.59	GO:0071447	cellular response to hydroperoxide
0.57	GO:2000310	regulation of NMDA receptor activity
0.57	GO:0007165	signal transduction
0.57	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
0.56	GO:0071346	cellular response to interferon-gamma
0.56	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.53	GO:0010508	positive regulation of autophagy
0.52	GO:0017148	negative regulation of translation

0.69	GO:0004674	protein serine/threonine kinase activity
0.58	GO:0017075	syntaxin-1 binding
0.53	GO:0005516	calmodulin binding
0.52	GO:0032559	adenyl ribonucleotide binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0042802	identical protein binding
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0019001	guanyl nucleotide binding
0.34	GO:0008234	cysteine-type peptidase activity

0.51	GO:0015629	actin cytoskeleton
0.42	GO:0005886	plasma membrane
0.39	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.69

GO:0004674

sp|P53365|ARFP2_HUMAN
Arfaptin-2
Search

ARFIP2

0.95	ADP ribosylation factor interacting protein 2

0.48	GO:0031529	ruffle organization
0.47	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation
0.37	GO:0030036	actin cytoskeleton organization
0.35	GO:0030032	lamellipodium assembly
0.34	GO:0007264	small GTPase mediated signal transduction

0.77	GO:0019904	protein domain specific binding
0.39	GO:0030742	GTP-dependent protein binding
0.38	GO:0070273	phosphatidylinositol-4-phosphate binding
0.38	GO:0045296	cadherin binding
0.37	GO:0042802	identical protein binding
0.35	GO:0048365	Rac GTPase binding
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.39	GO:0032588	trans-Golgi network membrane
0.38	GO:0001726	ruffle
0.37	GO:0005938	cell cortex
0.34	GO:0005829	cytosol
0.33	GO:0005886	plasma membrane

sp|P53367|ARFP1_HUMAN
Arfaptin-1
Search

ARFIP1

0.97	ADP-ribosylation factor interacting protein 1

0.80	GO:0050708	regulation of protein secretion
0.49	GO:0006886	intracellular protein transport
0.47	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation

0.84	GO:0070273	phosphatidylinositol-4-phosphate binding
0.77	GO:0019904	protein domain specific binding
0.55	GO:0045296	cadherin binding
0.35	GO:0042802	identical protein binding

0.85	GO:0032588	trans-Golgi network membrane
0.49	GO:0005829	cytosol

sp|P53370|NUDT6_HUMAN
Nucleoside diphosphate-linked moiety X motif 6
Search

NUDT6

0.94	Nucleoside diphosphate-linked moiety X motif 6

0.37

GO:0010469

regulation of receptor activity

0.51	GO:0016787	hydrolase activity
0.37	GO:0008083	growth factor activity

0.38	GO:0005634	nucleus
0.38	GO:0005739	mitochondrion

0.51

GO:0016787

sp|P53384|NUBP1_HUMAN
Cytosolic Fe-S cluster assembly factor NUBP1
Search

NUBP1

0.87	Cytosolic Fe-S cluster assembly factor nubp1-A

0.67	GO:0016226	iron-sulfur cluster assembly
0.57	GO:0072697	protein localization to cell cortex
0.56	GO:0051642	centrosome localization
0.56	GO:0010826	negative regulation of centrosome duplication
0.53	GO:0016049	cell growth
0.51	GO:0006879	cellular iron ion homeostasis
0.37	GO:0030030	cell projection organization

0.61	GO:0051539	4 iron, 4 sulfur cluster binding
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0046872	metal ion binding
0.35	GO:0005515	protein binding

0.49	GO:0005829	cytosol
0.42	GO:0005886	plasma membrane
0.39	GO:0005814	centriole
0.38	GO:0005929	cilium
0.37	GO:0070062	extracellular exosome
0.36	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|P53396|ACLY_HUMAN
ATP-citrate synthase
Search

ACLY

0.82	ATP-citrate synthase

0.75	GO:0006085	acetyl-CoA biosynthetic process
0.69	GO:0006101	citrate metabolic process
0.59	GO:0006629	lipid metabolic process
0.51	GO:0006107	oxaloacetate metabolic process
0.41	GO:0072330	monocarboxylic acid biosynthetic process
0.35	GO:0043312	neutrophil degranulation
0.35	GO:0046949	fatty-acyl-CoA biosynthetic process
0.34	GO:1902653	secondary alcohol biosynthetic process
0.34	GO:0015936	coenzyme A metabolic process
0.34	GO:0031325	positive regulation of cellular metabolic process

0.85	GO:0003878	ATP citrate synthase activity
0.56	GO:0048037	cofactor binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0046872	metal ion binding
0.45	GO:0016829	lyase activity
0.34	GO:0005515	protein binding

0.48	GO:0005829	cytosol
0.47	GO:0005654	nucleoplasm
0.46	GO:0009346	citrate lyase complex
0.41	GO:0005886	plasma membrane
0.36	GO:0070062	extracellular exosome
0.35	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0035578	azurophil granule lumen
0.34	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.85	EC:2.3.3.8	GO:0003878
0.85	KEGG:R00352	GO:0003878

sp|P53420|CO4A4_HUMAN
Collagen alpha-4(IV) chain
Search

COL4A4

0.75	Collagen type IV alpha 4 chain

0.59	GO:0032836	glomerular basement membrane development
0.46	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
0.46	GO:0035987	endodermal cell differentiation
0.45	GO:0016525	negative regulation of angiogenesis
0.45	GO:0071560	cellular response to transforming growth factor beta stimulus
0.38	GO:0006351	transcription, DNA-templated
0.37	GO:0014823	response to activity
0.37	GO:0030574	collagen catabolic process
0.36	GO:0007568	aging
0.34	GO:0001525	angiogenesis

0.78	GO:0005201	extracellular matrix structural constituent
0.34	GO:0005515	protein binding
0.34	GO:0003777	microtubule motor activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.78	GO:0005604	basement membrane
0.75	GO:0005581	collagen trimer
0.64	GO:0098645	collagen network
0.42	GO:0005615	extracellular space
0.36	GO:1903561	extracellular vesicle
0.36	GO:0005788	endoplasmic reticulum lumen
0.34	GO:0016459	myosin complex

sp|P53539|FOSB_HUMAN
Protein fosB
Search

FOSB

0.63	FBJ osteosarcoma oncogene B

0.71	GO:0006357	regulation of transcription by RNA polymerase II
0.61	GO:0071277	cellular response to calcium ion
0.55	GO:0006366	transcription by RNA polymerase II
0.54	GO:0045893	positive regulation of transcription, DNA-templated
0.45	GO:0051412	response to corticosterone
0.44	GO:0043278	response to morphine
0.44	GO:0032570	response to progesterone
0.44	GO:0051591	response to cAMP
0.43	GO:0007565	female pregnancy
0.43	GO:0009612	response to mechanical stimulus

0.61	GO:0003700	DNA binding transcription factor activity
0.58	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0008134	transcription factor binding

0.60	GO:0005634	nucleus
0.50	GO:0031974	membrane-enclosed lumen
0.45	GO:0044446	intracellular organelle part
0.37	GO:0005667	transcription factor complex
0.30	GO:0016020	membrane

sp|P53567|CEBPG_HUMAN
CCAAT/enhancer-binding protein gamma
Search

CEBPG

0.97	CCAAT/enhancer-binding protein gamma

0.60	GO:0043353	enucleate erythrocyte differentiation
0.60	GO:0045078	positive regulation of interferon-gamma biosynthetic process
0.59	GO:0042267	natural killer cell mediated cytotoxicity
0.57	GO:0045739	positive regulation of DNA repair
0.57	GO:0030183	B cell differentiation
0.56	GO:0043433	negative regulation of DNA binding transcription factor activity
0.52	GO:0006366	transcription by RNA polymerase II
0.52	GO:0045944	positive regulation of transcription by RNA polymerase II
0.49	GO:0016071	mRNA metabolic process
0.41	GO:0001889	liver development

0.57	GO:0003700	DNA binding transcription factor activity
0.55	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.52	GO:0042803	protein homodimerization activity
0.52	GO:0046982	protein heterodimerization activity
0.51	GO:0008134	transcription factor binding
0.40	GO:0044374	sequence-specific DNA binding, bending

0.49	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|P53582|MAP11_HUMAN
Methionine aminopeptidase 1
Search

METAP1

0.45	Methionine aminopeptidase

0.69	GO:0070084	protein initiator methionine removal
0.60	GO:0006508	proteolysis
0.37	GO:0070527	platelet aggregation
0.35	GO:0022400	regulation of rhodopsin mediated signaling pathway
0.35	GO:0018206	peptidyl-methionine modification
0.35	GO:0048203	vesicle targeting, trans-Golgi to endosome
0.34	GO:0031365	N-terminal protein amino acid modification
0.34	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
0.34	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation
0.34	GO:2000146	negative regulation of cell motility

0.73	GO:0008235	metalloexopeptidase activity
0.71	GO:0004177	aminopeptidase activity
0.53	GO:0046872	metal ion binding
0.34	GO:0035650	AP-1 adaptor complex binding
0.33	GO:0016758	transferase activity, transferring hexosyl groups
0.33	GO:0001883	purine nucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.33	GO:0032549	ribonucleoside binding
0.32	GO:0003735	structural constituent of ribosome
0.32	GO:0032555	purine ribonucleotide binding

0.35	GO:0005737	cytoplasm
0.33	GO:0005634	nucleus
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0043232	intracellular non-membrane-bounded organelle

0.71

EC:3.4.11

GO:0004177

sp|P53597|SUCA_HUMAN
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Search

SUCLG1

0.88	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

0.65	GO:0006099	tricarboxylic acid cycle
0.35	GO:0006104	succinyl-CoA metabolic process
0.34	GO:0006105	succinate metabolic process

0.81	GO:0004776	succinate-CoA ligase (GDP-forming) activity
0.72	GO:0004775	succinate-CoA ligase (ADP-forming) activity
0.54	GO:0048037	cofactor binding
0.50	GO:1901265	nucleoside phosphate binding
0.48	GO:0036094	small molecule binding
0.34	GO:0046982	protein heterodimerization activity
0.34	GO:0003723	RNA binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0043168	anion binding

0.57	GO:0005739	mitochondrion
0.46	GO:0005829	cytosol
0.42	GO:0019866	organelle inner membrane
0.41	GO:0031974	membrane-enclosed lumen
0.40	GO:0005886	plasma membrane
0.36	GO:0070062	extracellular exosome
0.36	GO:0042709	succinate-CoA ligase complex

0.81	EC:6.2.1.4	GO:0004776
0.81	KEGG:R00432	GO:0004776

sp|P53602|MVD1_HUMAN
Diphosphomevalonate decarboxylase
Search

MVD

0.60	Mevalonate diphosphate decarboxylase

0.82	GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway
0.81	GO:0006695	cholesterol biosynthetic process
0.54	GO:0008284	positive regulation of cell proliferation
0.36	GO:0006489	dolichyl diphosphate biosynthetic process
0.36	GO:0045540	regulation of cholesterol biosynthetic process
0.34	GO:0042493	response to drug
0.33	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
0.33	GO:0006468	protein phosphorylation
0.32	GO:0055114	oxidation-reduction process

0.84	GO:0004163	diphosphomevalonate decarboxylase activity
0.58	GO:0030544	Hsp70 protein binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0042803	protein homodimerization activity
0.34	GO:0020037	heme binding
0.33	GO:0004152	dihydroorotate dehydrogenase activity
0.33	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0003924	GTPase activity

0.68	GO:0005829	cytosol
0.36	GO:0005777	peroxisome
0.35	GO:0031907	microbody lumen
0.30	GO:0031224	intrinsic component of membrane

0.84	EC:4.1.1.33	GO:0004163
0.84	KEGG:R01121	GO:0004163

sp|P53609|PGTB1_HUMAN
Geranylgeranyl transferase type-1 subunit beta
Search

PGGT1B

0.80	LOW QUALITY PROTEIN: geranylgeranyl transferase type-1 subunit beta

0.59	GO:0018344	protein geranylgeranylation
0.46	GO:0001955	blood vessel maturation
0.40	GO:0035050	embryonic heart tube development
0.40	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process
0.38	GO:0045787	positive regulation of cell cycle
0.38	GO:0008284	positive regulation of cell proliferation
0.38	GO:0034097	response to cytokine
0.35	GO:0046579	positive regulation of Ras protein signal transduction
0.35	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.33	GO:0016567	protein ubiquitination

0.60	GO:0004661	protein geranylgeranyltransferase activity
0.38	GO:0019840	isoprenoid binding
0.38	GO:0042277	peptide binding
0.36	GO:0008270	zinc ion binding
0.34	GO:0008144	drug binding
0.34	GO:0004842	ubiquitin-protein transferase activity
0.33	GO:0005515	protein binding
0.33	GO:0016874	ligase activity

0.62	GO:0005953	CAAX-protein geranylgeranyltransferase complex
0.30	GO:0016020	membrane

0.60	EC:2.5.1	GO:0004661
0.34	KEGG:R03876	GO:0004842

sp|P53611|PGTB2_HUMAN
Geranylgeranyl transferase type-2 subunit beta
Search

RABGGTB

0.83	Rab geranylgeranyltransferase beta subunit

0.83	GO:0018344	protein geranylgeranylation
0.35	GO:0043687	post-translational protein modification
0.34	GO:0007601	visual perception
0.34	GO:0042981	regulation of apoptotic process
0.34	GO:0006461	protein complex assembly
0.33	GO:0006298	mismatch repair
0.33	GO:0055114	oxidation-reduction process

0.85	GO:0004663	Rab geranylgeranyltransferase activity
0.38	GO:0017137	Rab GTPase binding
0.36	GO:0008270	zinc ion binding
0.35	GO:0003995	acyl-CoA dehydrogenase activity
0.35	GO:0019840	isoprenoid binding
0.34	GO:0050660	flavin adenine dinucleotide binding
0.34	GO:0046982	protein heterodimerization activity
0.33	GO:0030983	mismatched DNA binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding

0.48	GO:0005968	Rab-protein geranylgeranyltransferase complex
0.34	GO:0005829	cytosol
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.85

EC:2.5.1.60

GO:0004663

sp|P53618|COPB_HUMAN
Coatomer subunit beta
Search

COPB1

0.62	Coatomer subunit beta

0.69	GO:0006886	intracellular protein transport
0.68	GO:0016192	vesicle-mediated transport
0.45	GO:0030903	notochord development
0.45	GO:0061053	somite development
0.35	GO:0002283	neutrophil activation involved in immune response
0.35	GO:0002446	neutrophil mediated immunity
0.33	GO:0032940	secretion by cell
0.33	GO:0016032	viral process
0.33	GO:0007165	signal transduction

0.61	GO:0005198	structural molecule activity
0.34	GO:0005515	protein binding
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.80	GO:0030126	COPI vesicle coat
0.72	GO:0000139	Golgi membrane
0.48	GO:0005829	cytosol
0.41	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.35	GO:0101003	ficolin-1-rich granule membrane
0.35	GO:0070821	tertiary granule membrane
0.35	GO:0005886	plasma membrane
0.35	GO:0005783	endoplasmic reticulum
0.34	GO:0030133	transport vesicle
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network

sp|P53621|COPA_HUMAN
Coatomer subunit alpha
Search

COPA

0.73	Coatomer subunit alpha

0.68	GO:0006886	intracellular protein transport
0.67	GO:0016192	vesicle-mediated transport
0.59	GO:0030157	pancreatic juice secretion
0.47	GO:0030903	notochord development
0.46	GO:0061053	somite development
0.37	GO:0010469	regulation of receptor activity

0.61	GO:0005198	structural molecule activity
0.37	GO:0005179	hormone activity
0.32	GO:0016740	transferase activity

0.79	GO:0030126	COPI vesicle coat
0.71	GO:0000139	Golgi membrane
0.50	GO:0005615	extracellular space
0.36	GO:1903561	extracellular vesicle
0.36	GO:0030133	transport vesicle
0.34	GO:0099503	secretory vesicle
0.34	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0005829	cytosol

0.32

GO:0016740

sp|P53634|CATC_HUMAN
Dipeptidyl peptidase 1
Search

CTSC

0.86	Prepro-cathepsin C

0.68	GO:0001913	T cell mediated cytotoxicity
0.63	GO:2001235	positive regulation of apoptotic signaling pathway
0.61	GO:0006508	proteolysis
0.59	GO:0006915	apoptotic process
0.46	GO:0044257	cellular protein catabolic process
0.37	GO:0007568	aging
0.37	GO:1903052	positive regulation of proteolysis involved in cellular protein catabolic process
0.36	GO:0010033	response to organic substance

0.72	GO:0008234	cysteine-type peptidase activity
0.67	GO:0016505	peptidase activator activity involved in apoptotic process
0.54	GO:0004252	serine-type endopeptidase activity
0.38	GO:0031404	chloride ion binding
0.37	GO:0043621	protein self-association
0.37	GO:0019902	phosphatase binding
0.36	GO:0051087	chaperone binding
0.36	GO:0042802	identical protein binding

0.61	GO:0005813	centrosome
0.55	GO:0005654	nucleoplasm
0.49	GO:0005764	lysosome
0.46	GO:0005615	extracellular space
0.36	GO:0005794	Golgi apparatus
0.35	GO:0005783	endoplasmic reticulum
0.30	GO:0031224	intrinsic component of membrane

0.72

GO:0008234

sp|P53667|LIMK1_HUMAN
LIM domain kinase 1
Search

LIMK1

0.92	LIM domain kinase 1

0.62	GO:0006468	protein phosphorylation
0.60	GO:0051496	positive regulation of stress fiber assembly
0.59	GO:0051444	negative regulation of ubiquitin-protein transferase activity
0.57	GO:0045773	positive regulation of axon extension
0.45	GO:0030036	actin cytoskeleton organization
0.44	GO:0001878	response to yeast
0.42	GO:0035556	intracellular signal transduction
0.36	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis

0.62	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0031072	heat shock protein binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0046872	metal ion binding
0.51	GO:0046982	protein heterodimerization activity
0.43	GO:0004871	signal transducer activity
0.35	GO:0005201	extracellular matrix structural constituent

0.55	GO:0030027	lamellipodium
0.55	GO:0043005	neuron projection
0.55	GO:0016607	nuclear speck
0.54	GO:0005925	focal adhesion
0.49	GO:0005829	cytosol
0.45	GO:0005794	Golgi apparatus
0.37	GO:0030427	site of polarized growth
0.36	GO:0120038	plasma membrane bounded cell projection part
0.35	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0005578	proteinaceous extracellular matrix

sp|P53671|LIMK2_HUMAN
LIM domain kinase 2
Search

LIMK2

0.97	LIM domain kinase 2

0.62	GO:0006468	protein phosphorylation
0.51	GO:0007283	spermatogenesis
0.40	GO:0035556	intracellular signal transduction
0.36	GO:0042325	regulation of phosphorylation
0.34	GO:0007281	germ cell development

0.63	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0046872	metal ion binding
0.49	GO:0046982	protein heterodimerization activity
0.41	GO:0004871	signal transducer activity

0.52	GO:0005801	cis-Golgi network
0.44	GO:0005634	nucleus
0.39	GO:0005737	cytoplasm

sp|P53672|CRBA2_HUMAN
Beta-crystallin A2
Search

CRYBA2

0.95	Beta-crystallin A2

0.67	GO:0002088	lens development in camera-type eye
0.61	GO:0007601	visual perception
0.35	GO:0006478	peptidyl-tyrosine sulfation

0.68	GO:0005212	structural constituent of eye lens
0.60	GO:0042803	protein homodimerization activity
0.35	GO:0008476	protein-tyrosine sulfotransferase activity

0.30

GO:0044425

membrane part

0.35

EC:2.8.2.20

GO:0008476

sp|P53673|CRBA4_HUMAN
Beta-crystallin A4
Search

CRYBA4

0.97	Beta crystallin A4 chain

0.57	GO:0007601	visual perception
0.52	GO:0043010	camera-type eye development
0.37	GO:2000210	positive regulation of anoikis
0.36	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
0.36	GO:0051898	negative regulation of protein kinase B signaling
0.36	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.36	GO:0032007	negative regulation of TOR signaling
0.36	GO:0001818	negative regulation of cytokine production
0.35	GO:0043043	peptide biosynthetic process
0.34	GO:0044267	cellular protein metabolic process

0.73	GO:0005212	structural constituent of eye lens
0.35	GO:0003735	structural constituent of ribosome
0.35	GO:0005515	protein binding

0.36	GO:0015935	small ribosomal subunit
0.34	GO:0005634	nucleus

sp|P53674|CRBB1_HUMAN
Beta-crystallin B1
Search

CRYBB1

0.70	Acyl-CoA dehydrogenase, C-2 to C-3 short chain

0.75	GO:0007601	visual perception
0.36	GO:0006478	peptidyl-tyrosine sulfation
0.35	GO:0043010	camera-type eye development
0.32	GO:0055114	oxidation-reduction process

0.82	GO:0005212	structural constituent of eye lens
0.36	GO:0008476	protein-tyrosine sulfotransferase activity
0.36	GO:0005515	protein binding
0.33	GO:0003995	acyl-CoA dehydrogenase activity
0.33	GO:0050660	flavin adenine dinucleotide binding

0.30

GO:0031224

intrinsic component of membrane

0.36

EC:2.8.2.20

GO:0008476

sp|P53675|CLH2_HUMAN
Clathrin heavy chain 2
Search

CLTCL1

0.66	Clathrin heavy chain

0.83	GO:0048268	clathrin coat assembly
0.69	GO:0006886	intracellular protein transport
0.69	GO:0016192	vesicle-mediated transport
0.49	GO:0046326	positive regulation of glucose import
0.47	GO:0016482	cytosolic transport
0.47	GO:0016197	endosomal transport
0.46	GO:0000278	mitotic cell cycle
0.44	GO:0098657	import into cell
0.37	GO:1900126	negative regulation of hyaluronan biosynthetic process
0.35	GO:0006914	autophagy

0.85	GO:0032051	clathrin light chain binding
0.62	GO:0005198	structural molecule activity
0.39	GO:0019901	protein kinase binding
0.36	GO:0097718	disordered domain specific binding
0.35	GO:0004386	helicase activity
0.35	GO:1990763	arrestin family protein binding
0.35	GO:1990381	ubiquitin-specific protease binding
0.35	GO:0050750	low-density lipoprotein particle receptor binding
0.34	GO:0003725	double-stranded RNA binding
0.34	GO:0042802	identical protein binding

0.84	GO:0071439	clathrin complex
0.83	GO:0030130	clathrin coat of trans-Golgi network vesicle
0.82	GO:0030132	clathrin coat of coated pit
0.51	GO:0097443	sorting endosome
0.50	GO:0005819	spindle
0.47	GO:0005802	trans-Golgi network
0.47	GO:0005770	late endosome
0.43	GO:0005829	cytosol
0.42	GO:0005764	lysosome
0.39	GO:0043209	myelin sheath

sp|P53677|AP3M2_HUMAN
AP-3 complex subunit mu-2
Search

AP3M2

0.92	LOW QUALITY PROTEIN: AP-3 complex subunit mu-2

0.68	GO:0006886	intracellular protein transport
0.67	GO:0016192	vesicle-mediated transport
0.60	GO:0008089	anterograde axonal transport
0.59	GO:0047496	vesicle transport along microtubule
0.58	GO:0097480	establishment of synaptic vesicle localization
0.34	GO:0099643	signal release from synapse
0.34	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.34	GO:0006836	neurotransmitter transport
0.34	GO:0001505	regulation of neurotransmitter levels

0.43

GO:0017137

Rab GTPase binding

0.78	GO:0030131	clathrin adaptor complex
0.59	GO:1904115	axon cytoplasm
0.39	GO:0030659	cytoplasmic vesicle membrane
0.38	GO:0005794	Golgi apparatus
0.34	GO:0005765	lysosomal membrane
0.34	GO:0098793	presynapse

sp|P53680|AP2S1_HUMAN
AP-2 complex subunit sigma
Search

AP2S1

0.56	AP complex subunit sigma

0.69	GO:0006886	intracellular protein transport
0.69	GO:0016192	vesicle-mediated transport
0.39	GO:0098657	import into cell
0.35	GO:0032802	low-density lipoprotein particle receptor catabolic process
0.35	GO:0034383	low-density lipoprotein particle clearance
0.35	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.34	GO:0060071	Wnt signaling pathway, planar cell polarity pathway
0.34	GO:0048013	ephrin receptor signaling pathway
0.34	GO:0048268	clathrin coat assembly
0.34	GO:0030100	regulation of endocytosis

0.71	GO:0008565	protein transporter activity
0.34	GO:0035615	clathrin adaptor activity
0.30	GO:0003824	catalytic activity

0.85	GO:0030122	AP-2 adaptor complex
0.35	GO:0036020	endolysosome membrane
0.34	GO:0008023	transcription elongation factor complex
0.33	GO:0005829	cytosol

sp|P53701|CCHL_HUMAN
Cytochrome c-type heme lyase
Search

HCCS

0.65	Cytochrome c-type heme lyase

0.49	GO:0018063	cytochrome c-heme linkage
0.34	GO:0009887	animal organ morphogenesis
0.33	GO:0046160	heme a metabolic process
0.33	GO:0006783	heme biosynthetic process
0.33	GO:0055114	oxidation-reduction process

0.85	GO:0004408	holocytochrome-c synthase activity
0.54	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding
0.33	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors

0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.85

EC:4.4.1.17

GO:0004408

sp|P53708|ITA8_HUMAN
Integrin alpha-8
Search

ITGA8

0.95	Integrin alpha-V

0.78	GO:0007229	integrin-mediated signaling pathway
0.71	GO:0007155	cell adhesion
0.64	GO:0048333	mesodermal cell differentiation
0.61	GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
0.60	GO:0001822	kidney development
0.60	GO:0000904	cell morphogenesis involved in differentiation
0.58	GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus
0.58	GO:0048745	smooth muscle tissue development
0.56	GO:0007613	memory
0.56	GO:0042472	inner ear morphogenesis

0.43	GO:1990430	extracellular matrix protein binding
0.43	GO:0038132	neuregulin binding
0.43	GO:0019960	C-X3-C chemokine binding
0.42	GO:0031994	insulin-like growth factor I binding
0.42	GO:0001968	fibronectin binding
0.42	GO:0017134	fibroblast growth factor binding
0.42	GO:0005178	integrin binding
0.42	GO:0001846	opsonin binding
0.41	GO:0050840	extracellular matrix binding
0.41	GO:0002020	protease binding

0.79	GO:0008305	integrin complex
0.58	GO:0009986	cell surface
0.54	GO:0045177	apical part of cell
0.54	GO:0005783	endoplasmic reticulum
0.45	GO:0031256	leading edge membrane
0.45	GO:0031253	cell projection membrane
0.45	GO:0005925	focal adhesion
0.43	GO:0035868	alphav-beta3 integrin-HMGB1 complex
0.43	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex
0.41	GO:0001726	ruffle

sp|P53778|MK12_HUMAN
Mitogen-activated protein kinase 12
Search

MAPK12

0.57	Mitogen-activated protein kinase

0.79	GO:0000165	MAPK cascade
0.56	GO:0045445	myoblast differentiation
0.53	GO:0018105	peptidyl-serine phosphorylation
0.39	GO:0060255	regulation of macromolecule metabolic process
0.37	GO:0045786	negative regulation of cell cycle
0.36	GO:0032755	positive regulation of interleukin-6 production
0.36	GO:0007049	cell cycle
0.36	GO:0006975	DNA damage induced protein phosphorylation
0.35	GO:0006970	response to osmotic stress
0.35	GO:0048010	vascular endothelial growth factor receptor signaling pathway

0.81	GO:0004707	MAP kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0000287	magnesium ion binding
0.34	GO:0005515	protein binding

0.45	GO:0005622	intracellular
0.38	GO:0043227	membrane-bounded organelle
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0044422	organelle part

0.81	EC:2.7.11.24	GO:0004707
0.81	KEGG:R00162	GO:0004707

sp|P53779|MK10_HUMAN
Mitogen-activated protein kinase 10
Search

MAPK10

0.58	Mitogen-activated protein kinase

0.79	GO:0000165	MAPK cascade
0.47	GO:0007399	nervous system development
0.46	GO:0031098	stress-activated protein kinase signaling cascade
0.45	GO:0001889	liver development
0.43	GO:0048468	cell development
0.38	GO:0010468	regulation of gene expression
0.37	GO:0042752	regulation of circadian rhythm
0.37	GO:0048511	rhythmic process
0.36	GO:0009416	response to light stimulus
0.36	GO:0007626	locomotory behavior

0.81	GO:0004707	MAP kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0004708	MAP kinase kinase activity
0.35	GO:0005515	protein binding

0.45	GO:0005622	intracellular
0.44	GO:0043005	neuron projection
0.38	GO:0043227	membrane-bounded organelle
0.36	GO:0014069	postsynaptic density
0.35	GO:0043204	perikaryon
0.34	GO:0005886	plasma membrane
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044422	organelle part

0.81	EC:2.7.11.24	GO:0004707
0.81	KEGG:R00162	GO:0004707

sp|P53794|SC5A3_HUMAN
Sodium/myo-inositol cotransporter
Search

SLC5A3

0.96	Sodium/myo-inositol cotransporter

0.57	GO:0015798	myo-inositol transport
0.55	GO:0055085	transmembrane transport
0.51	GO:0043576	regulation of respiratory gaseous exchange
0.50	GO:0006020	inositol metabolic process
0.50	GO:0007422	peripheral nervous system development
0.38	GO:0006814	sodium ion transport
0.33	GO:0043043	peptide biosynthetic process
0.33	GO:0044267	cellular protein metabolic process
0.32	GO:0010467	gene expression
0.32	GO:0009059	macromolecule biosynthetic process

0.57	GO:0022857	transmembrane transporter activity
0.34	GO:0019843	rRNA binding
0.33	GO:0003735	structural constituent of ribosome

0.41	GO:0005887	integral component of plasma membrane
0.33	GO:0005840	ribosome

sp|P53801|PTTG_HUMAN
Pituitary tumor-transforming gene 1 protein-interacting protein
Search

PTTG1IP

0.95	Pituitary tumor-transforming 1 protein-interacting protein isoform B

0.47	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
0.47	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
0.45	GO:0031398	positive regulation of protein ubiquitination
0.44	GO:0006606	protein import into nucleus
0.44	GO:1903364	positive regulation of cellular protein catabolic process

0.46

GO:0002039

p53 binding

0.42	GO:0005654	nucleoplasm
0.38	GO:0070062	extracellular exosome
0.36	GO:0005737	cytoplasm
0.35	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P53803|RPAB4_HUMAN
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Search

POLR2K

0.96	RNA polymerase II subunit K

0.58	GO:0006351	transcription, DNA-templated
0.35	GO:0035019	somatic stem cell population maintenance
0.35	GO:0032481	positive regulation of type I interferon production
0.35	GO:0060964	regulation of gene silencing by miRNA
0.35	GO:0045815	positive regulation of gene expression, epigenetic
0.35	GO:0006356	regulation of transcription by RNA polymerase I
0.35	GO:0008543	fibroblast growth factor receptor signaling pathway
0.34	GO:0016073	snRNA metabolic process
0.34	GO:0050434	positive regulation of viral transcription
0.34	GO:0006283	transcription-coupled nucleotide-excision repair

0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.55	GO:0003677	DNA binding
0.34	GO:0046872	metal ion binding
0.33	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.32	GO:0020037	heme binding

0.53	GO:0005665	DNA-directed RNA polymerase II, core complex
0.48	GO:0005736	DNA-directed RNA polymerase I complex
0.48	GO:0005666	DNA-directed RNA polymerase III complex
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.70

GO:0003899

sp|P53804|TTC3_HUMAN
E3 ubiquitin-protein ligase TTC3
Search

TTC3

0.94	Tetratricopeptide repeat protein 3

0.81	GO:0070936	protein K48-linked ubiquitination
0.70	GO:0006511	ubiquitin-dependent protein catabolic process
0.44	GO:0010771	negative regulation of cell morphogenesis involved in differentiation
0.43	GO:0045665	negative regulation of neuron differentiation

0.71

GO:0004842

ubiquitin-protein transferase activity

0.69	GO:0005730	nucleolus
0.65	GO:0005829	cytosol
0.41	GO:0005773	vacuole
0.30	GO:0031224	intrinsic component of membrane

0.71

KEGG:R03876

GO:0004842

sp|P53805|RCAN1_HUMAN
Calcipressin-1
Search

RCAN1

0.97	Down syndrome critical region gene 1

0.84	GO:0033173	calcineurin-NFAT signaling cascade
0.50	GO:0070884	regulation of calcineurin-NFAT signaling cascade
0.47	GO:0043666	regulation of phosphoprotein phosphatase activity
0.37	GO:0007519	skeletal muscle tissue development
0.37	GO:0031987	locomotion involved in locomotory behavior
0.37	GO:0007614	short-term memory
0.37	GO:0002931	response to ischemia
0.37	GO:0051151	negative regulation of smooth muscle cell differentiation
0.36	GO:0014904	myotube cell development
0.36	GO:0048747	muscle fiber development

0.52	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity
0.51	GO:0003676	nucleic acid binding
0.36	GO:0042802	identical protein binding
0.35	GO:0030346	protein phosphatase 2B binding
0.33	GO:0003700	DNA binding transcription factor activity

0.45	GO:0005622	intracellular
0.34	GO:0043227	membrane-bounded organelle
0.30	GO:0016020	membrane

sp|P53814|SMTN_HUMAN
Smoothelin
Search

SMTN

0.75	smoothelin

0.81	GO:0060452	positive regulation of cardiac muscle contraction
0.79	GO:0003085	negative regulation of systemic arterial blood pressure
0.30	GO:0007517	muscle organ development
0.30	GO:0006936	muscle contraction

0.30	GO:0005515	protein binding
0.30	GO:0008307	structural constituent of muscle

0.53	GO:0005856	cytoskeleton
0.30	GO:0005737	cytoplasm

sp|P53816|PA216_HUMAN
HRAS-like suppressor 3
Search

PLA2G16

0.96	Retinoic acid receptor responder protein 3

0.52	GO:1904177	regulation of adipose tissue development
0.50	GO:0046485	ether lipid metabolic process
0.50	GO:0006644	phospholipid metabolic process
0.48	GO:0046486	glycerolipid metabolic process
0.48	GO:0006638	neutral lipid metabolic process
0.47	GO:0007031	peroxisome organization
0.45	GO:0016042	lipid catabolic process
0.44	GO:0008285	negative regulation of cell proliferation
0.42	GO:0008610	lipid biosynthetic process
0.41	GO:0090407	organophosphate biosynthetic process

0.54	GO:0004623	phospholipase A2 activity
0.50	GO:0008970	phosphatidylcholine 1-acylhydrolase activity
0.42	GO:0016746	transferase activity, transferring acyl groups
0.41	GO:0102568	phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
0.41	GO:0102567	phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
0.40	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity
0.40	GO:0052739	phosphatidylserine 1-acylhydrolase activity
0.37	GO:0003924	GTPase activity
0.36	GO:0032550	purine ribonucleoside binding
0.36	GO:0019001	guanyl nucleotide binding

0.47	GO:0048471	perinuclear region of cytoplasm
0.46	GO:0005777	peroxisome
0.44	GO:0005783	endoplasmic reticulum
0.39	GO:0031903	microbody membrane
0.36	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.54	EC:3.1.1.4	GO:0004623
0.40	KEGG:R04034	GO:0052739

sp|P53985|MOT1_HUMAN
Monocarboxylate transporter 1
Search

SLC16A1

0.91	Solute carrier family 16 (Monocarboxylic acid transporters), member 1

0.80	GO:0035873	lactate transmembrane transport
0.78	GO:0051780	behavioral response to nutrient
0.75	GO:0032094	response to food
0.71	GO:0050796	regulation of insulin secretion
0.70	GO:0007098	centrosome cycle
0.69	GO:0042593	glucose homeostasis
0.55	GO:0006629	lipid metabolic process
0.45	GO:1901475	pyruvate transmembrane transport
0.40	GO:0071407	cellular response to organic cyclic compound

0.80	GO:0015129	lactate transmembrane transporter activity
0.43	GO:0050833	pyruvate transmembrane transporter activity
0.40	GO:0042803	protein homodimerization activity
0.34	GO:0097159	organic cyclic compound binding

0.67	GO:0005887	integral component of plasma membrane
0.66	GO:0005813	centrosome
0.65	GO:0030054	cell junction
0.53	GO:0005739	mitochondrion

sp|P53990|IST1_HUMAN
IST1 homolog
Search

IST1

0.97	IST1, ESCRT-III associated factor

0.85	GO:0046745	viral capsid secondary envelopment
0.83	GO:0009838	abscission
0.82	GO:0048672	positive regulation of collateral sprouting
0.74	GO:0061640	cytoskeleton-dependent cytokinesis
0.72	GO:0045862	positive regulation of proteolysis
0.65	GO:0035890	exit from host
0.65	GO:0015031	protein transport
0.60	GO:0019058	viral life cycle
0.38	GO:0048675	axon extension
0.38	GO:0007032	endosome organization

0.85	GO:0090541	MIT domain binding
0.74	GO:0045296	cadherin binding
0.69	GO:0032403	protein complex binding

0.81	GO:0090543	Flemming body
0.76	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.71	GO:0005813	centrosome
0.66	GO:0000785	chromatin
0.63	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|P53992|SC24C_HUMAN
Protein transport protein Sec24C
Search

SEC24C

0.88	SEC24 homolog C, COPII coat complex component

0.78	GO:0006888	ER to Golgi vesicle-mediated transport
0.69	GO:0006886	intracellular protein transport
0.67	GO:0035459	cargo loading into vesicle
0.63	GO:0051668	localization within membrane
0.62	GO:0048194	Golgi vesicle budding
0.60	GO:0001701	in utero embryonic development
0.36	GO:0036065	fucosylation
0.35	GO:0043413	macromolecule glycosylation
0.35	GO:0009101	glycoprotein biosynthetic process
0.34	GO:0036211	protein modification process

0.63	GO:0008270	zinc ion binding
0.62	GO:0000149	SNARE binding
0.36	GO:0008417	fucosyltransferase activity

0.80	GO:0030127	COPII vesicle coat
0.57	GO:0000139	Golgi membrane
0.54	GO:0005829	cytosol
0.36	GO:0031985	Golgi cisterna
0.30	GO:0016021	integral component of membrane

0.36

GO:0008417

sp|P53999|TCP4_HUMAN
Activated RNA polymerase II transcriptional coactivator p15
Search

SUB1

0.93	Activated RNA polymerase II transcriptional coactivator p15

0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.43	GO:0051260	protein homooligomerization
0.42	GO:0031334	positive regulation of protein complex assembly
0.42	GO:0060395	SMAD protein signal transduction
0.42	GO:0051254	positive regulation of RNA metabolic process
0.41	GO:0010557	positive regulation of macromolecule biosynthetic process
0.41	GO:0031328	positive regulation of cellular biosynthetic process
0.41	GO:0032392	DNA geometric change

0.78	GO:0003713	transcription coactivator activity
0.54	GO:0003677	DNA binding
0.45	GO:0033613	activating transcription factor binding
0.43	GO:0042802	identical protein binding
0.42	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
0.41	GO:0003678	DNA helicase activity
0.35	GO:0003723	RNA binding

0.45	GO:0005667	transcription factor complex
0.43	GO:0005730	nucleolus
0.38	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

sp|P54098|DPOG1_HUMAN
DNA polymerase subunit gamma-1
Search

POLG

0.95	DNA polymerase gamma, catalytic subunit

0.65	GO:0071897	DNA biosynthetic process
0.65	GO:0006260	DNA replication
0.63	GO:0006287	base-excision repair, gap-filling
0.51	GO:0032042	mitochondrial DNA metabolic process
0.42	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.42	GO:0055093	response to hyperoxia
0.42	GO:0010332	response to gamma radiation
0.42	GO:0071333	cellular response to glucose stimulus
0.42	GO:0007568	aging
0.39	GO:0009416	response to light stimulus

0.69	GO:0003887	DNA-directed DNA polymerase activity
0.60	GO:0002020	protease binding
0.56	GO:0003682	chromatin binding
0.54	GO:0003677	DNA binding
0.45	GO:0008408	3'-5' exonuclease activity

0.84	GO:0005760	gamma DNA polymerase complex
0.59	GO:0042645	mitochondrial nucleoid
0.46	GO:0043234	protein complex
0.42	GO:0043195	terminal bouton
0.38	GO:0070062	extracellular exosome
0.35	GO:0031966	mitochondrial membrane
0.35	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.69

GO:0003887

sp|P54105|ICLN_HUMAN
Methylosome subunit pICln
Search

CLNS1A

0.93	Methylosome subunit pICln

0.84	GO:0006884	cell volume homeostasis
0.80	GO:0000387	spliceosomal snRNP assembly
0.76	GO:0006821	chloride transport
0.44	GO:0048675	axon extension
0.34	GO:0071805	potassium ion transmembrane transport
0.34	GO:0098661	inorganic anion transmembrane transport
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.50	GO:0046982	protein heterodimerization activity
0.36	GO:1990935	splicing factor binding
0.35	GO:0061778	intracellular chloride channel activity
0.34	GO:0005267	potassium channel activity
0.34	GO:0022839	ion gated channel activity
0.34	GO:0008381	mechanosensitive ion channel activity
0.34	GO:0003723	RNA binding

0.85	GO:0034709	methylosome
0.85	GO:0034715	pICln-Sm protein complex
0.68	GO:0005829	cytosol
0.55	GO:0005886	plasma membrane
0.48	GO:0005654	nucleoplasm
0.39	GO:0005856	cytoskeleton
0.34	GO:0031213	RSF complex
0.30	GO:0031224	intrinsic component of membrane

sp|P54107|CRIS1_HUMAN
Cysteine-rich secretory protein 1
Search

CRISP1

0.92	Cysteine-rich secretory protein A

0.51	GO:0060046	regulation of acrosome reaction
0.50	GO:0007339	binding of sperm to zona pellucida
0.43	GO:0065009	regulation of molecular function
0.40	GO:0060325	face morphogenesis
0.39	GO:0030198	extracellular matrix organization
0.38	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization
0.36	GO:0006955	immune response
0.35	GO:0006952	defense response
0.34	GO:0002446	neutrophil mediated immunity
0.34	GO:0043299	leukocyte degranulation

0.50	GO:0005246	calcium channel regulator activity
0.39	GO:0008201	heparin binding

0.66	GO:0005576	extracellular region
0.38	GO:0030133	transport vesicle
0.37	GO:0005634	nucleus
0.35	GO:0030141	secretory granule
0.34	GO:0060205	cytoplasmic vesicle lumen
0.30	GO:0016020	membrane

sp|P54108|CRIS3_HUMAN
Cysteine-rich secretory protein 3
Search

0.94	Cysteine-rich secretory protein 3

0.43	GO:0009405	pathogenesis
0.38	GO:0019953	sexual reproduction
0.37	GO:0098609	cell-cell adhesion
0.36	GO:0060046	regulation of acrosome reaction
0.36	GO:0048609	multicellular organismal reproductive process
0.36	GO:0009988	cell-cell recognition
0.36	GO:0043312	neutrophil degranulation
0.35	GO:0045087	innate immune response
0.34	GO:0065009	regulation of molecular function
0.33	GO:0072488	ammonium transmembrane transport

0.44	GO:0090729	toxin activity
0.36	GO:0005246	calcium channel regulator activity
0.33	GO:0008519	ammonium transmembrane transporter activity
0.32	GO:0046872	metal ion binding

0.66	GO:0005576	extracellular region
0.45	GO:0042581	specific granule
0.36	GO:1904724	tertiary granule lumen
0.36	GO:0034774	secretory granule lumen
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P54132|BLM_HUMAN
Bloom syndrome protein
Search

BLM

0.92	Bloom syndrome RecQ like helicase

0.69	GO:0032508	DNA duplex unwinding
0.66	GO:0006260	DNA replication
0.65	GO:0006310	DNA recombination
0.64	GO:0006281	DNA repair
0.62	GO:0072757	cellular response to camptothecin
0.62	GO:0061820	telomeric D-loop disassembly
0.62	GO:0072711	cellular response to hydroxyurea
0.61	GO:0035786	protein complex oligomerization
0.61	GO:0044806	G-quadruplex DNA unwinding
0.60	GO:0010165	response to X-ray

0.79	GO:0043140	ATP-dependent 3'-5' DNA helicase activity
0.64	GO:0061749	forked DNA-dependent helicase activity
0.63	GO:1905773	8-hydroxy-2'-deoxyguanosine DNA binding
0.63	GO:0061821	telomeric D-loop binding
0.61	GO:0000405	bubble DNA binding
0.60	GO:0051880	G-quadruplex DNA binding
0.60	GO:0036310	annealing helicase activity
0.60	GO:0000403	Y-form DNA binding
0.60	GO:0000400	four-way junction DNA binding
0.58	GO:0002039	p53 binding

0.60	GO:0005634	nucleus
0.55	GO:0000781	chromosome, telomeric region
0.54	GO:0000793	condensed chromosome
0.50	GO:0005829	cytosol
0.49	GO:0070013	intracellular organelle lumen
0.38	GO:0005657	replication fork
0.30	GO:0016020	membrane

0.33

GO:0004674

sp|P54136|SYRC_HUMAN
Arginine--tRNA ligase, cytoplasmic
Search

RARS

0.67	Arginyl-tRNA synthetase

0.77	GO:0006420	arginyl-tRNA aminoacylation
0.34	GO:0006364	rRNA processing
0.34	GO:0008033	tRNA processing
0.34	GO:0032259	methylation

0.78	GO:0004814	arginine-tRNA ligase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0045296	cadherin binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0034618	arginine binding
0.36	GO:0000049	tRNA binding
0.34	GO:0008168	methyltransferase activity

0.58	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex
0.49	GO:0005829	cytosol
0.49	GO:0005654	nucleoplasm
0.45	GO:0005739	mitochondrion
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.78

EC:6.1.1.19

GO:0004814

sp|P54198|HIRA_HUMAN
Protein HIRA
Search

sp|P54219|VMAT1_HUMAN
Chromaffin granule amine transporter
Search

SLC18A1

0.89	Solute carrier family 18 (vesicular monoamine transporter), member 2

0.69	GO:0006855	drug transmembrane transport
0.60	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle
0.58	GO:0006837	serotonin transport
0.57	GO:0001975	response to amphetamine
0.55	GO:0007626	locomotory behavior
0.52	GO:0009791	post-embryonic development
0.37	GO:0035864	response to potassium ion

0.69	GO:0015238	drug transmembrane transporter activity
0.59	GO:0015222	serotonin transmembrane transporter activity
0.32	GO:0097159	organic cyclic compound binding

0.53	GO:0098793	presynapse
0.47	GO:0005887	integral component of plasma membrane
0.37	GO:0042583	chromaffin granule

sp|P54252|ATX3_HUMAN
Ataxin-3
Search

ATXN3

0.92	Ataxin 3 variant ref

0.76	GO:0016579	protein deubiquitination
0.48	GO:0035640	exploration behavior
0.47	GO:0071218	cellular response to misfolded protein
0.47	GO:0010810	regulation of cell-substrate adhesion
0.46	GO:0034605	cellular response to heat
0.46	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins
0.45	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.42	GO:1904327	protein localization to cytosolic proteasome complex
0.41	GO:1904294	positive regulation of ERAD pathway
0.40	GO:0045104	intermediate filament cytoskeleton organization

0.80	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.46	GO:0031625	ubiquitin protein ligase binding
0.41	GO:0051117	ATPase binding
0.41	GO:0061578	Lys63-specific deubiquitinase activity
0.40	GO:1990380	Lys48-specific deubiquitinase activity
0.38	GO:0042802	identical protein binding
0.37	GO:0004407	histone deacetylase activity
0.36	GO:0001012	RNA polymerase II regulatory region DNA binding

0.49	GO:0042405	nuclear inclusion body
0.45	GO:0043233	organelle lumen
0.40	GO:0031966	mitochondrial membrane
0.38	GO:0043232	intracellular non-membrane-bounded organelle
0.38	GO:0005789	endoplasmic reticulum membrane
0.37	GO:0005886	plasma membrane
0.37	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.37

EC:3.5.1.98

GO:0004407

sp|P54253|ATX1_HUMAN
Ataxin-1
Search

ATXN1

0.96

Ataxin-1

0.56	GO:0051168	nuclear export
0.54	GO:0045892	negative regulation of transcription, DNA-templated
0.41	GO:0035176	social behavior
0.41	GO:0007613	memory
0.41	GO:0007612	learning
0.40	GO:0007420	brain development
0.39	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway
0.39	GO:0060252	positive regulation of glial cell proliferation
0.39	GO:0048286	lung alveolus development
0.38	GO:0007632	visual behavior

0.66	GO:0034046	poly(G) binding
0.63	GO:0008266	poly(U) RNA binding
0.62	GO:0043621	protein self-association
0.61	GO:0008022	protein C-terminus binding
0.56	GO:0042802	identical protein binding
0.37	GO:0003682	chromatin binding
0.35	GO:0003677	DNA binding

0.66	GO:0042272	nuclear RNA export factor complex
0.65	GO:0042405	nuclear inclusion body
0.62	GO:0016363	nuclear matrix
0.55	GO:0005730	nucleolus
0.52	GO:0005829	cytosol
0.37	GO:0098794	postsynapse
0.30	GO:0016020	membrane

sp|P54257|HAP1_HUMAN
Huntingtin-associated protein 1
Search

HAP1

0.58	Huntingtin-associated protein 1

0.88	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
0.87	GO:1902513	regulation of organelle transport along microtubule
0.87	GO:1902857	positive regulation of non-motile cilium assembly
0.87	GO:0021979	hypothalamus cell differentiation
0.87	GO:0032901	positive regulation of neurotrophin production
0.86	GO:0048011	neurotrophin TRK receptor signaling pathway
0.86	GO:0008089	anterograde axonal transport
0.85	GO:0047496	vesicle transport along microtubule
0.85	GO:0021549	cerebellum development
0.84	GO:1902430	negative regulation of amyloid-beta formation

0.85	GO:0048403	brain-derived neurotrophic factor binding
0.78	GO:0044325	ion channel binding
0.47	GO:0019904	protein domain specific binding
0.46	GO:0042802	identical protein binding
0.45	GO:0005102	receptor binding

0.85	GO:1904115	axon cytoplasm
0.85	GO:0016234	inclusion body
0.84	GO:0005776	autophagosome
0.83	GO:0005814	centriole
0.78	GO:0005813	centrosome
0.75	GO:0008021	synaptic vesicle
0.72	GO:0005764	lysosome
0.69	GO:0030054	cell junction
0.65	GO:0005783	endoplasmic reticulum
0.61	GO:0015629	actin cytoskeleton

sp|P54259|ATN1_HUMAN
Atrophin-1
Search

ATN1

0.81	Arginine-glutamic acid dipeptide repeats

0.70	GO:0051402	neuron apoptotic process
0.67	GO:0000122	negative regulation of transcription by RNA polymerase II
0.51	GO:0021691	cerebellar Purkinje cell layer maturation
0.50	GO:0021942	radial glia guided migration of Purkinje cell
0.50	GO:0021930	cerebellar granule cell precursor proliferation
0.50	GO:0048755	branching morphogenesis of a nerve
0.48	GO:0048813	dendrite morphogenesis
0.48	GO:0006366	transcription by RNA polymerase II
0.48	GO:0045944	positive regulation of transcription by RNA polymerase II
0.46	GO:0006338	chromatin remodeling

0.69	GO:0003714	transcription corepressor activity
0.62	GO:0019904	protein domain specific binding
0.55	GO:0003682	chromatin binding
0.53	GO:0043565	sequence-specific DNA binding
0.52	GO:0001105	RNA polymerase II transcription coactivator activity
0.52	GO:0008270	zinc ion binding
0.51	GO:0003700	DNA binding transcription factor activity
0.48	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding
0.41	GO:0090729	toxin activity
0.40	GO:0008432	JUN kinase binding

0.68	GO:0016363	nuclear matrix
0.60	GO:0005654	nucleoplasm
0.45	GO:0048471	perinuclear region of cytoplasm
0.44	GO:0030054	cell junction
0.40	GO:1902494	catalytic complex
0.38	GO:0031252	cell leading edge

sp|P54274|TERF1_HUMAN
Telomeric repeat-binding factor 1
Search

TERF1

0.94	TTAGGG-repeat binding factor 1 transcript variant 1

0.77	GO:0000723	telomere maintenance
0.66	GO:1904911	negative regulation of establishment of RNA localization to telomere
0.66	GO:1904790	regulation of shelterin complex assembly
0.66	GO:1904850	negative regulation of establishment of protein localization to telomere
0.65	GO:1905839	negative regulation of telomeric D-loop disassembly
0.65	GO:1905778	negative regulation of exonuclease activity
0.62	GO:0032211	negative regulation of telomere maintenance via telomerase
0.61	GO:0051974	negative regulation of telomerase activity
0.59	GO:0045141	meiotic telomere clustering
0.58	GO:2001252	positive regulation of chromosome organization

0.82	GO:0042162	telomeric DNA binding
0.75	GO:0042803	protein homodimerization activity
0.64	GO:0071532	ankyrin repeat binding
0.61	GO:0003720	telomerase activity
0.60	GO:0098847	sequence-specific single stranded DNA binding
0.60	GO:0008301	DNA binding, bending
0.55	GO:0003690	double-stranded DNA binding
0.42	GO:0008022	protein C-terminus binding
0.39	GO:0008017	microtubule binding
0.39	GO:0046982	protein heterodimerization activity

0.80	GO:0000784	nuclear chromosome, telomeric region
0.62	GO:0000782	telomere cap complex
0.58	GO:0001650	fibrillar center
0.56	GO:0016604	nuclear body
0.41	GO:0005819	spindle
0.36	GO:0030870	Mre11 complex
0.34	GO:0005737	cytoplasm
0.34	GO:0001673	male germ cell nucleus
0.33	GO:0033267	axon part

0.61

GO:0003720

sp|P54277|PMS1_HUMAN
PMS1 protein homolog 1
Search

PMS1

0.96	PMS1 postmeiotic segregation increased 1

0.73	GO:0006298	mismatch repair
0.38	GO:0042493	response to drug

0.74	GO:0030983	mismatched DNA binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0003697	single-stranded DNA binding
0.41	GO:0016887	ATPase activity

0.60	GO:0005634	nucleus
0.48	GO:0032300	mismatch repair complex
0.39	GO:0044446	intracellular organelle part

0.41

GO:0016887

sp|P54278|PMS2_HUMAN
Mismatch repair endonuclease PMS2
Search

PMS2

0.92	PMS1 homolog 2, mismatch repair system component

0.75	GO:0006298	mismatch repair
0.60	GO:0016446	somatic hypermutation of immunoglobulin genes
0.42	GO:0048298	positive regulation of isotype switching to IgA isotypes
0.41	GO:0048304	positive regulation of isotype switching to IgG isotypes
0.41	GO:0016447	somatic recombination of immunoglobulin gene segments
0.38	GO:0042493	response to drug

0.76	GO:0030983	mismatched DNA binding
0.75	GO:0032407	MutSalpha complex binding
0.63	GO:0003697	single-stranded DNA binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0016887	ATPase activity

0.65	GO:0036464	cytoplasmic ribonucleoprotein granule
0.59	GO:0015630	microtubule cytoskeleton
0.59	GO:0032389	MutLalpha complex
0.58	GO:0005654	nucleoplasm
0.57	GO:0005829	cytosol
0.48	GO:0005886	plasma membrane

0.45

GO:0016887

sp|P54284|CACB3_HUMAN
Voltage-dependent L-type calcium channel subunit beta-3
Search

CACNB3

0.97	Voltage-dependent calcium channel beta subunit

0.75	GO:0070588	calcium ion transmembrane transport
0.54	GO:0050852	T cell receptor signaling pathway
0.48	GO:1901385	regulation of voltage-gated calcium channel activity
0.48	GO:0007528	neuromuscular junction development
0.45	GO:0007268	chemical synaptic transmission
0.41	GO:0055113	epiboly involved in gastrulation with mouth forming second
0.40	GO:0098903	regulation of membrane repolarization during action potential
0.39	GO:0060402	calcium ion transport into cytosol
0.39	GO:0072659	protein localization to plasma membrane
0.35	GO:0051899	membrane depolarization

0.80	GO:0005245	voltage-gated calcium channel activity
0.38	GO:0019901	protein kinase binding

0.79	GO:0005891	voltage-gated calcium channel complex
0.42	GO:0030315	T-tubule
0.38	GO:0016324	apical plasma membrane
0.34	GO:0005829	cytosol

sp|P54289|CA2D1_HUMAN
Voltage-dependent calcium channel subunit alpha-2/delta-1
Search

CACNA2D1

0.94	Voltage-dependent calcium channel alpha-2 delta subunit

0.87	GO:0086048	membrane depolarization during bundle of His cell action potential
0.87	GO:1902514	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
0.86	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
0.86	GO:1904646	cellular response to amyloid-beta
0.85	GO:0086002	cardiac muscle cell action potential involved in contraction
0.85	GO:0086091	regulation of heart rate by cardiac conduction
0.77	GO:0070588	calcium ion transmembrane transport
0.56	GO:1901843	positive regulation of high voltage-gated calcium channel activity
0.53	GO:0098903	regulation of membrane repolarization during action potential
0.53	GO:0060402	calcium ion transport into cytosol

0.88	GO:0086057	voltage-gated calcium channel activity involved in bundle of His cell action potential
0.42	GO:0005515	protein binding
0.40	GO:0046872	metal ion binding

0.87	GO:1990454	L-type voltage-gated calcium channel complex
0.84	GO:0016529	sarcoplasmic reticulum
0.46	GO:0070062	extracellular exosome

sp|P54296|MYOM2_HUMAN
Myomesin-2
Search

MYOM2

0.92	M-protein, striated muscle

0.80	GO:0006936	muscle contraction
0.67	GO:0071688	striated muscle myosin thick filament assembly
0.65	GO:0045214	sarcomere organization
0.58	GO:0007015	actin filament organization
0.44	GO:0002074	extraocular skeletal muscle development

0.75	GO:0019900	kinase binding
0.68	GO:0097493	structural molecule activity conferring elasticity
0.67	GO:0051371	muscle alpha-actinin binding
0.66	GO:0008307	structural constituent of muscle
0.60	GO:0051015	actin filament binding
0.33	GO:0005200	structural constituent of cytoskeleton

0.84	GO:0031430	M band
0.67	GO:0005859	muscle myosin complex
0.64	GO:0030018	Z disc
0.42	GO:0032982	myosin filament
0.37	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

sp|P54315|LIPR1_HUMAN
Inactive pancreatic lipase-related protein 1
Search

0.59	Pancreatic triacylglycerol lipase

0.69	GO:0016042	lipid catabolic process
0.58	GO:0007586	digestion
0.54	GO:0061365	positive regulation of triglyceride lipase activity
0.52	GO:0030301	cholesterol transport
0.51	GO:0006968	cellular defense response
0.47	GO:0003008	system process
0.36	GO:0042750	hibernation
0.35	GO:0001523	retinoid metabolic process
0.35	GO:0043434	response to peptide hormone
0.34	GO:0009791	post-embryonic development

0.78	GO:0004806	triglyceride lipase activity
0.36	GO:0046872	metal ion binding

0.65

GO:0005576

extracellular region

0.78

EC:3.1.1.3

GO:0004806

sp|P54317|LIPR2_HUMAN
Pancreatic lipase-related protein 2
Search

0.58	Triacylglycerol lipase

0.70	GO:0016042	lipid catabolic process
0.61	GO:0007586	digestion
0.56	GO:0006968	cellular defense response
0.54	GO:0061365	positive regulation of triglyceride lipase activity
0.51	GO:0030301	cholesterol transport
0.47	GO:0003008	system process

0.77

GO:0004806

triglyceride lipase activity

0.65	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.77

EC:3.1.1.3

GO:0004806

sp|P54368|OAZ1_HUMAN
Ornithine decarboxylase antizyme 1
Search

OAZ1

0.90	Ornithine decarboxylase antizyme

0.75	GO:0006595	polyamine metabolic process
0.72	GO:0043086	negative regulation of catalytic activity
0.56	GO:1902268	negative regulation of polyamine transmembrane transport
0.55	GO:0045732	positive regulation of protein catabolic process
0.54	GO:0090316	positive regulation of intracellular protein transport
0.43	GO:0042401	cellular biogenic amine biosynthetic process
0.37	GO:0006521	regulation of cellular amino acid metabolic process
0.34	GO:0006368	transcription elongation from RNA polymerase II promoter

0.85	GO:0008073	ornithine decarboxylase inhibitor activity
0.37	GO:0005515	protein binding

0.68	GO:0005829	cytosol
0.41	GO:0005634	nucleus
0.33	GO:0031974	membrane-enclosed lumen
0.33	GO:0043234	protein complex
0.33	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|P54577|SYYC_HUMAN
Tyrosine--tRNA ligase, cytoplasmic
Search

YARS

0.54	Tyrosine--tRNA ligase, cytoplasmic

0.73	GO:0006437	tyrosyl-tRNA aminoacylation
0.45	GO:0006915	apoptotic process
0.42	GO:0051716	cellular response to stimulus
0.39	GO:0023052	signaling
0.39	GO:0007154	cell communication
0.39	GO:0006950	response to stress
0.37	GO:0065007	biological regulation

0.75	GO:0004831	tyrosine-tRNA ligase activity
0.68	GO:0000049	tRNA binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0005153	interleukin-8 receptor binding
0.40	GO:0004871	signal transducer activity

0.74	GO:0017102	methionyl glutamyl tRNA synthetase complex
0.74	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex
0.50	GO:0016604	nuclear body
0.46	GO:0005829	cytosol
0.43	GO:0005615	extracellular space

0.75	EC:6.1.1.1	GO:0004831
0.75	KEGG:R02918	GO:0004831

sp|P54578|UBP14_HUMAN
Ubiquitin carboxyl-terminal hydrolase 14
Search

USP14

0.93	Ubiquitin specific peptidase 14 (TRNA-guanine transglycosylase)

0.75	GO:0016579	protein deubiquitination
0.72	GO:0006511	ubiquitin-dependent protein catabolic process
0.57	GO:1903070	negative regulation of ER-associated ubiquitin-dependent protein catabolic process
0.52	GO:0007268	chemical synaptic transmission
0.52	GO:0050920	regulation of chemotaxis
0.50	GO:0010951	negative regulation of endopeptidase activity
0.39	GO:0045087	innate immune response

0.75	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.53	GO:0070628	proteasome binding
0.50	GO:0004866	endopeptidase inhibitor activity
0.35	GO:0008193	tRNA guanylyltransferase activity
0.34	GO:0004197	cysteine-type endopeptidase activity

0.51	GO:0045202	synapse
0.50	GO:0009986	cell surface
0.48	GO:0031410	cytoplasmic vesicle
0.47	GO:0005829	cytosol
0.40	GO:0005634	nucleus
0.38	GO:1905369	endopeptidase complex
0.37	GO:0070062	extracellular exosome
0.36	GO:0043234	protein complex
0.35	GO:0005886	plasma membrane

0.75

GO:0036459

sp|P54619|AAKG1_HUMAN
5'-AMP-activated protein kinase subunit gamma-1
Search

PRKAG1

0.96	5'-AMP-activated protein kinase gamma-1 non-catalytic subunit variant 1

0.55	GO:0016310	phosphorylation
0.51	GO:0010604	positive regulation of macromolecule metabolic process
0.49	GO:0051170	nuclear import
0.45	GO:0036211	protein modification process
0.45	GO:0006110	regulation of glycolytic process
0.43	GO:0044267	cellular protein metabolic process
0.42	GO:0010799	regulation of peptidyl-threonine phosphorylation
0.42	GO:0019217	regulation of fatty acid metabolic process
0.42	GO:0033674	positive regulation of kinase activity
0.42	GO:0071901	negative regulation of protein serine/threonine kinase activity

0.57	GO:0016301	kinase activity
0.54	GO:0019901	protein kinase binding
0.45	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.45	GO:0008607	phosphorylase kinase regulator activity
0.44	GO:0043531	ADP binding
0.44	GO:0008603	cAMP-dependent protein kinase regulator activity
0.44	GO:0140096	catalytic activity, acting on a protein
0.44	GO:0004862	cAMP-dependent protein kinase inhibitor activity
0.43	GO:0030295	protein kinase activator activity
0.41	GO:0016208	AMP binding

0.47	GO:0031588	nucleotide-activated protein kinase complex
0.45	GO:0005634	nucleus
0.39	GO:0070013	intracellular organelle lumen
0.38	GO:0034708	methyltransferase complex
0.37	GO:0044446	intracellular organelle part
0.37	GO:0070062	extracellular exosome
0.36	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.45

GO:0016773

sp|P54646|AAPK2_HUMAN
5'-AMP-activated protein kinase catalytic subunit alpha-2
Search

PRKAA2

0.58	Non-specific serine/threonine protein kinase

0.64	GO:0035404	histone-serine phosphorylation
0.63	GO:0071380	cellular response to prostaglandin E stimulus
0.62	GO:0042149	cellular response to glucose starvation
0.61	GO:0032007	negative regulation of TOR signaling
0.60	GO:0042752	regulation of circadian rhythm
0.58	GO:0042593	glucose homeostasis
0.58	GO:0010508	positive regulation of autophagy
0.57	GO:0043066	negative regulation of apoptotic process
0.57	GO:0014823	response to activity
0.54	GO:0016241	regulation of macroautophagy

0.70	GO:0004674	protein serine/threonine kinase activity
0.64	GO:0035173	histone kinase activity
0.56	GO:0003682	chromatin binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0004712	protein serine/threonine/tyrosine kinase activity
0.51	GO:0060089	molecular transducer activity
0.46	GO:0050405	[acetyl-CoA carboxylase] kinase activity

0.58	GO:0016607	nuclear speck
0.49	GO:0031588	nucleotide-activated protein kinase complex
0.49	GO:0005794	Golgi apparatus
0.44	GO:0005829	cytosol
0.38	GO:0016324	apical plasma membrane
0.32	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

0.70

GO:0004674

sp|P54652|HSP72_HUMAN
Heat shock-related 70 kDa protein 2
Search

HSPA2

0.61	Inducible heat shock protein 70

0.64	GO:0009409	response to cold
0.60	GO:0009408	response to heat
0.56	GO:0031662	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
0.55	GO:1901896	positive regulation of calcium-transporting ATPase activity
0.55	GO:0070194	synaptonemal complex disassembly
0.54	GO:0090084	negative regulation of inclusion body assembly
0.53	GO:0007141	male meiosis I
0.51	GO:0007286	spermatid development
0.48	GO:0042026	protein refolding
0.39	GO:0032570	response to progesterone

0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0097718	disordered domain specific binding
0.47	GO:0008289	lipid binding
0.46	GO:0019899	enzyme binding
0.46	GO:0051082	unfolded protein binding
0.40	GO:0033142	progesterone receptor binding
0.35	GO:0055131	C3HC4-type RING finger domain binding

0.54	GO:0036128	CatSper complex
0.54	GO:0072687	meiotic spindle
0.53	GO:0001673	male germ cell nucleus
0.52	GO:0000795	synaptonemal complex
0.51	GO:0043209	myelin sheath
0.48	GO:0009986	cell surface
0.46	GO:0005829	cytosol
0.42	GO:0005739	mitochondrion
0.39	GO:0043204	perikaryon
0.38	GO:0072562	blood microparticle

0.33

GO:0016887

sp|P54687|BCAT1_HUMAN
Branched-chain-amino-acid aminotransferase, cytosolic
Search

BCAT1

0.54	Branched-chain-amino-acid aminotransferase

0.70	GO:0009082	branched-chain amino acid biosynthetic process
0.43	GO:0006573	valine metabolic process
0.43	GO:0006551	leucine metabolic process
0.40	GO:1901607	alpha-amino acid biosynthetic process
0.35	GO:0006550	isoleucine catabolic process
0.34	GO:1990830	cellular response to leukemia inhibitory factor
0.33	GO:0010817	regulation of hormone levels
0.33	GO:0016192	vesicle-mediated transport

0.78	GO:0052654	L-leucine transaminase activity
0.78	GO:0052655	L-valine transaminase activity
0.78	GO:0052656	L-isoleucine transaminase activity

0.39	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.78	EC:2.6.1.42	GO:0052654
0.78	KEGG:R01090	GO:0052654

sp|P54707|AT12A_HUMAN
Potassium-transporting ATPase alpha chain 2
Search

ATP12A

0.64	Sodium/potassium-transporting ATPase subunit alpha

0.84	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
0.75	GO:0090662	ATP hydrolysis coupled transmembrane transport
0.72	GO:0006814	sodium ion transport
0.71	GO:0006813	potassium ion transport
0.64	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.46	GO:0006885	regulation of pH
0.45	GO:0055075	potassium ion homeostasis
0.40	GO:1902600	hydrogen ion transmembrane transport
0.40	GO:0030317	flagellated sperm motility
0.39	GO:0009566	fertilization

0.84	GO:0005391	sodium:potassium-exchanging ATPase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0046872	metal ion binding
0.48	GO:0008900	potassium:proton exchanging ATPase activity
0.33	GO:0005515	protein binding

0.45	GO:0016323	basolateral plasma membrane
0.36	GO:0090533	cation-transporting ATPase complex
0.35	GO:0016324	apical plasma membrane
0.34	GO:0005887	integral component of plasma membrane
0.32	GO:0005737	cytoplasm

0.84

GO:0005391

sp|P54709|AT1B3_HUMAN
Sodium/potassium-transporting ATPase subunit beta-3
Search

ATP1B3

0.80	Sodium/potassium-transporting ATPase subunit beta

0.72	GO:0006814	sodium ion transport
0.71	GO:0006813	potassium ion transport
0.58	GO:1903288	positive regulation of potassium ion import
0.58	GO:1903278	positive regulation of sodium ion export across plasma membrane
0.57	GO:0006883	cellular sodium ion homeostasis
0.57	GO:0086009	membrane repolarization
0.56	GO:1901018	positive regulation of potassium ion transmembrane transporter activity
0.55	GO:0030007	cellular potassium ion homeostasis
0.55	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
0.54	GO:0140115	export across plasma membrane

0.55	GO:0051117	ATPase binding
0.55	GO:0005391	sodium:potassium-exchanging ATPase activity
0.53	GO:0001671	ATPase activator activity

0.84	GO:0005890	sodium:potassium-exchanging ATPase complex
0.42	GO:0042470	melanosome
0.40	GO:0098590	plasma membrane region
0.39	GO:0045121	membrane raft
0.37	GO:0070062	extracellular exosome
0.36	GO:0045177	apical part of cell

0.55

GO:0005391

sp|P54710|ATNG_HUMAN
Sodium/potassium-transporting ATPase subunit gamma
Search

FXYD2

0.73	Sodium/potassium-transporting ATPase subunit gamma

0.82	GO:2000649	regulation of sodium ion transmembrane transporter activity
0.73	GO:0006814	sodium ion transport
0.71	GO:0006813	potassium ion transport
0.68	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
0.64	GO:0001558	regulation of cell growth
0.62	GO:0042127	regulation of cell proliferation
0.61	GO:0090662	ATP hydrolysis coupled transmembrane transport
0.61	GO:1903779	regulation of cardiac conduction
0.59	GO:0099587	inorganic ion import across plasma membrane
0.58	GO:0140115	export across plasma membrane

0.82	GO:0017080	sodium channel regulator activity
0.70	GO:0005216	ion channel activity
0.68	GO:0005391	sodium:potassium-exchanging ATPase activity
0.45	GO:0005515	protein binding

0.68	GO:0005890	sodium:potassium-exchanging ATPase complex
0.66	GO:0016323	basolateral plasma membrane
0.65	GO:0070062	extracellular exosome
0.48	GO:0043231	intracellular membrane-bounded organelle

0.68

GO:0005391

sp|P54725|RD23A_HUMAN
UV excision repair protein RAD23 homolog A
Search

RAD23A

0.97	UV excision repair protein RAD23 like protein A

0.76	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.72	GO:0006289	nucleotide-excision repair
0.61	GO:0045070	positive regulation of viral genome replication
0.60	GO:0031648	protein destabilization
0.60	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
0.57	GO:1901800	positive regulation of proteasomal protein catabolic process
0.56	GO:0045787	positive regulation of cell cycle
0.38	GO:0007283	spermatogenesis
0.37	GO:0051276	chromosome organization
0.36	GO:0016579	protein deubiquitination

0.72	GO:0003684	damaged DNA binding
0.62	GO:1990381	ubiquitin-specific protease binding
0.61	GO:0031593	polyubiquitin modification-dependent protein binding
0.56	GO:0019900	kinase binding
0.35	GO:0003697	single-stranded DNA binding

0.61	GO:0005634	nucleus
0.55	GO:0005815	microtubule organizing center
0.52	GO:0005829	cytosol
0.51	GO:0031974	membrane-enclosed lumen
0.47	GO:0043234	protein complex
0.39	GO:1905369	endopeptidase complex
0.38	GO:1990391	DNA repair complex

sp|P54727|RD23B_HUMAN
UV excision repair protein RAD23 homolog B
Search

RAD23B

0.91	UV excision repair protein RAD23 like protein B

0.77	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.73	GO:0006289	nucleotide-excision repair
0.53	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
0.50	GO:0007283	spermatogenesis
0.45	GO:0051276	chromosome organization
0.38	GO:0048568	embryonic organ development
0.35	GO:0065004	protein-DNA complex assembly
0.34	GO:0016579	protein deubiquitination
0.34	GO:0006457	protein folding
0.33	GO:0045070	positive regulation of viral genome replication

0.72	GO:0003684	damaged DNA binding
0.53	GO:0031593	polyubiquitin modification-dependent protein binding
0.34	GO:0003697	single-stranded DNA binding
0.33	GO:1990381	ubiquitin-specific protease binding
0.33	GO:0019900	kinase binding

0.61	GO:0005634	nucleus
0.49	GO:1990391	DNA repair complex
0.46	GO:0005829	cytosol
0.46	GO:0031974	membrane-enclosed lumen
0.43	GO:0043234	protein complex
0.42	GO:0044446	intracellular organelle part
0.38	GO:1905369	endopeptidase complex
0.32	GO:0015630	microtubule cytoskeleton
0.30	GO:0016020	membrane

sp|P54750|PDE1A_HUMAN
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Search

PDE1A

0.56	Phosphodiesterase

0.60	GO:0007165	signal transduction
0.41	GO:0046069	cGMP catabolic process
0.41	GO:0034391	regulation of smooth muscle cell apoptotic process
0.40	GO:0006198	cAMP catabolic process
0.40	GO:0048660	regulation of smooth muscle cell proliferation
0.39	GO:0048793	pronephros development
0.37	GO:0007608	sensory perception of smell

0.79	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.54	GO:0046872	metal ion binding
0.41	GO:0030553	cGMP binding
0.37	GO:0005516	calmodulin binding

0.39	GO:0043025	neuronal cell body
0.37	GO:0005929	cilium
0.36	GO:0005634	nucleus
0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.79

GO:0004114

sp|P54753|EPHB3_HUMAN
Ephrin type-B receptor 3
Search

EPHB3

0.96	EPH receptor B3

0.84	GO:0048013	ephrin receptor signaling pathway
0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.63	GO:0034446	substrate adhesion-dependent cell spreading
0.60	GO:0046777	protein autophosphorylation
0.58	GO:0022038	corpus callosum development
0.58	GO:0060997	dendritic spine morphogenesis
0.58	GO:0016477	cell migration
0.57	GO:0021952	central nervous system projection neuron axonogenesis
0.57	GO:0022407	regulation of cell-cell adhesion
0.57	GO:0031290	retinal ganglion cell axon guidance

0.85	GO:0005003	ephrin receptor activity
0.59	GO:0008046	axon guidance receptor activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.67

GO:0005887

integral component of plasma membrane

sp|P54756|EPHA5_HUMAN
Ephrin type-A receptor 5
Search

EPHA5

0.81	EPH receptor A5

0.83	GO:0048013	ephrin receptor signaling pathway
0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.70	GO:0071372	cellular response to follicle-stimulating hormone stimulus
0.69	GO:1904321	response to forskolin
0.66	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
0.66	GO:0021766	hippocampus development
0.65	GO:1901655	cellular response to ketone
0.62	GO:0007411	axon guidance
0.62	GO:0035690	cellular response to drug
0.62	GO:0071396	cellular response to lipid

0.84	GO:0005003	ephrin receptor activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.64	GO:0005887	integral component of plasma membrane
0.62	GO:0005912	adherens junction
0.40	GO:0005769	early endosome

sp|P54760|EPHB4_HUMAN
Ephrin type-B receptor 4
Search

EPHB4

0.87	EPH receptor B4

0.84	GO:0048013	ephrin receptor signaling pathway
0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.65	GO:0002042	cell migration involved in sprouting angiogenesis
0.63	GO:0046777	protein autophosphorylation
0.57	GO:0007155	cell adhesion
0.47	GO:0035475	angioblast cell migration involved in selective angioblast sprouting
0.45	GO:0022038	corpus callosum development
0.45	GO:0060997	dendritic spine morphogenesis
0.45	GO:0021952	central nervous system projection neuron axonogenesis
0.45	GO:0031290	retinal ganglion cell axon guidance

0.84	GO:0005003	ephrin receptor activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0008046	axon guidance receptor activity

0.65	GO:0005887	integral component of plasma membrane
0.37	GO:0070062	extracellular exosome

sp|P54762|EPHB1_HUMAN
Ephrin type-B receptor 1
Search

EPHB1

0.96	EPH receptor B1

0.84	GO:0048013	ephrin receptor signaling pathway
0.75	GO:0018108	peptidyl-tyrosine phosphorylation
0.74	GO:0014719	skeletal muscle satellite cell activation
0.72	GO:1902723	negative regulation of skeletal muscle satellite cell proliferation
0.72	GO:0021631	optic nerve morphogenesis
0.72	GO:1902725	negative regulation of satellite cell differentiation
0.72	GO:0050965	detection of temperature stimulus involved in sensory perception of pain
0.71	GO:0060997	dendritic spine morphogenesis
0.70	GO:0021952	central nervous system projection neuron axonogenesis
0.70	GO:0031290	retinal ganglion cell axon guidance

0.85	GO:0005003	ephrin receptor activity
0.72	GO:0008046	axon guidance receptor activity
0.61	GO:0032403	protein complex binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.70	GO:0032433	filopodium tip
0.66	GO:0005887	integral component of plasma membrane
0.65	GO:0031901	early endosome membrane
0.65	GO:0045121	membrane raft
0.64	GO:0030424	axon
0.56	GO:0005783	endoplasmic reticulum
0.55	GO:0005829	cytosol

sp|P54764|EPHA4_HUMAN
Ephrin type-A receptor 4
Search

EPHA4

0.92	Eph receptor A4, like

0.83	GO:0048013	ephrin receptor signaling pathway
0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.76	GO:2001108	positive regulation of Rho guanyl-nucleotide exchange factor activity
0.73	GO:1905247	positive regulation of aspartic-type peptidase activity
0.73	GO:1902959	regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
0.72	GO:1905244	regulation of modification of synaptic structure
0.72	GO:0097155	fasciculation of sensory neuron axon
0.72	GO:0097156	fasciculation of motor neuron axon
0.72	GO:1902004	positive regulation of amyloid-beta formation
0.71	GO:0021957	corticospinal tract morphogenesis

0.84	GO:0005003	ephrin receptor activity
0.76	GO:0097161	DH domain binding
0.73	GO:0042731	PH domain binding
0.68	GO:1990782	protein tyrosine kinase binding
0.59	GO:0042802	identical protein binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0046875	ephrin receptor binding

0.67	GO:0031901	early endosome membrane
0.66	GO:0005887	integral component of plasma membrane
0.64	GO:0030425	dendrite
0.63	GO:0030424	axon
0.41	GO:0043204	perikaryon
0.41	GO:0044309	neuron spine
0.41	GO:0031594	neuromuscular junction
0.41	GO:0043679	axon terminus
0.41	GO:0030175	filopodium
0.41	GO:0030426	growth cone

sp|P54792|DVLP1_HUMAN
Putative segment polarity protein dishevelled homolog DVL1P1
Search

DVL1

0.90	Segment polarity protein dishevelled like protein DVL-1

0.76	GO:0016055	Wnt signaling pathway
0.62	GO:0035556	intracellular signal transduction
0.58	GO:0090178	regulation of establishment of planar polarity involved in neural tube closure
0.56	GO:0014022	neural plate elongation
0.56	GO:0001843	neural tube closure
0.55	GO:0071340	skeletal muscle acetylcholine-gated channel clustering
0.55	GO:0060134	prepulse inhibition
0.54	GO:0048668	collateral sprouting
0.54	GO:0060029	convergent extension involved in organogenesis
0.54	GO:0035372	protein localization to microtubule

0.56	GO:0005109	frizzled binding
0.52	GO:0008013	beta-catenin binding
0.49	GO:0019901	protein kinase binding
0.47	GO:0042802	identical protein binding
0.39	GO:0048365	Rac GTPase binding

0.55	GO:1990909	Wnt signalosome
0.52	GO:0016328	lateral plasma membrane
0.52	GO:0030426	growth cone
0.50	GO:0030424	axon
0.50	GO:0030136	clathrin-coated vesicle
0.50	GO:0098793	presynapse
0.47	GO:0015630	microtubule cytoskeleton
0.43	GO:0005829	cytosol
0.38	GO:0043197	dendritic spine
0.38	GO:0014069	postsynaptic density

sp|P54793|ARSF_HUMAN
Arylsulfatase F
Search

ARSF

0.46	Arylsulfatase F

0.39	GO:0006687	glycosphingolipid metabolic process
0.39	GO:0043687	post-translational protein modification
0.34	GO:0001501	skeletal system development

0.73	GO:0008484	sulfuric ester hydrolase activity
0.35	GO:0046872	metal ion binding

0.42	GO:0012505	endomembrane system
0.38	GO:0043231	intracellular membrane-bounded organelle
0.38	GO:0070062	extracellular exosome
0.38	GO:0044444	cytoplasmic part
0.36	GO:0070013	intracellular organelle lumen
0.35	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

0.73

GO:0008484

sp|P54802|ANAG_HUMAN
Alpha-N-acetylglucosaminidase
Search

NAGLU

0.71	Lysosomal alpha-N-acetyl glucosaminidase

0.84	GO:0046548	retinal rod cell development
0.82	GO:0042474	middle ear morphogenesis
0.81	GO:0021680	cerebellar Purkinje cell layer development
0.81	GO:0045475	locomotor rhythm
0.80	GO:0060119	inner ear receptor cell development
0.78	GO:0007040	lysosome organization
0.40	GO:0015991	ATP hydrolysis coupled proton transport
0.38	GO:0006027	glycosaminoglycan catabolic process
0.37	GO:0016573	histone acetylation
0.36	GO:0051781	positive regulation of cell division

0.46	GO:0004561	alpha-N-acetylglucosaminidase activity
0.38	GO:0004402	histone acetyltransferase activity
0.37	GO:0015078	hydrogen ion transmembrane transporter activity
0.36	GO:0030151	molybdenum ion binding
0.35	GO:0030170	pyridoxal phosphate binding

0.75	GO:0070062	extracellular exosome
0.41	GO:0043202	lysosomal lumen
0.40	GO:0033179	proton-transporting V-type ATPase, V0 domain
0.35	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.46

EC:3.2.1.50

GO:0004561

sp|P54803|GALC_HUMAN
Galactocerebrosidase
Search

GALC

0.93	galactocerebrosidase precursor

0.86	GO:0006683	galactosylceramide catabolic process
0.34	GO:0045859	regulation of protein kinase activity

0.86	GO:0004336	galactosylceramidase activity
0.34	GO:0019887	protein kinase regulator activity

0.46	GO:0005764	lysosome
0.44	GO:0005739	mitochondrion
0.38	GO:0070062	extracellular exosome
0.36	GO:0005775	vacuolar lumen
0.35	GO:0005956	protein kinase CK2 complex
0.30	GO:0016020	membrane

0.86

EC:3.2.1.46

GO:0004336

sp|P54819|KAD2_HUMAN
Adenylate kinase 2, mitochondrial
Search

AK2

0.58	Adenylate kinase 2, mitochondrial

0.75	GO:0006172	ADP biosynthetic process
0.68	GO:0046939	nucleotide phosphorylation
0.63	GO:0046033	AMP metabolic process
0.54	GO:0046034	ATP metabolic process
0.44	GO:0060218	hematopoietic stem cell differentiation
0.42	GO:0002521	leukocyte differentiation
0.35	GO:0046060	dATP metabolic process
0.35	GO:0015949	nucleobase-containing small molecule interconversion
0.35	GO:0097066	response to thyroid hormone
0.35	GO:0035172	hemocyte proliferation

0.77	GO:0004017	adenylate kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.69	GO:0005758	mitochondrial intermembrane space
0.55	GO:0097226	sperm mitochondrial sheath
0.42	GO:0031966	mitochondrial membrane
0.42	GO:0019866	organelle inner membrane
0.37	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome
0.33	GO:0005634	nucleus

0.77

EC:2.7.4.3

GO:0004017

sp|P54821|PRRX1_HUMAN
Paired mesoderm homeobox protein 1
Search

PRRX1

0.97	Paired mesoderm homeobox protein 1

0.65	GO:0007275	multicellular organism development
0.57	GO:1904888	cranial skeletal system development
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.55	GO:0002053	positive regulation of mesenchymal cell proliferation
0.55	GO:0097150	neuronal stem cell population maintenance
0.55	GO:0045880	positive regulation of smoothened signaling pathway
0.54	GO:0060021	palate development
0.54	GO:0001709	cell fate determination

0.65	GO:0043565	sequence-specific DNA binding
0.56	GO:0071837	HMG box domain binding
0.55	GO:0001105	RNA polymerase II transcription coactivator activity
0.54	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.51	GO:0001012	RNA polymerase II regulatory region DNA binding
0.48	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.47	GO:0005829	cytosol
0.46	GO:0031974	membrane-enclosed lumen
0.42	GO:0044446	intracellular organelle part

sp|P54826|GAS1_HUMAN
Growth arrest-specific protein 1
Search

GAS1

0.91	Growth arrest-specific protein 1

0.79	GO:0060628	regulation of ER to Golgi vesicle-mediated transport
0.77	GO:0010955	negative regulation of protein processing
0.72	GO:0045930	negative regulation of mitotic cell cycle
0.72	GO:0035924	cellular response to vascular endothelial growth factor stimulus
0.64	GO:0008589	regulation of smoothened signaling pathway
0.61	GO:0045165	cell fate commitment
0.60	GO:0048589	developmental growth
0.57	GO:0042981	regulation of apoptotic process
0.49	GO:0042473	outer ear morphogenesis
0.48	GO:0021904	dorsal/ventral neural tube patterning

0.41

GO:0005515

protein binding

0.52	GO:0005886	plasma membrane
0.50	GO:0031225	anchored component of membrane
0.30	GO:0016021	integral component of membrane

sp|P54829|PTN5_HUMAN
Tyrosine-protein phosphatase non-receptor type 5
Search

PTPN5

0.97	Tyrosine-protein phosphatase non-receptor type 5

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.42	GO:0038128	ERBB2 signaling pathway
0.41	GO:0010633	negative regulation of epithelial cell migration
0.41	GO:0043409	negative regulation of MAPK cascade
0.40	GO:0070372	regulation of ERK1 and ERK2 cascade
0.40	GO:0001701	in utero embryonic development
0.35	GO:1903492	response to acetylsalicylate
0.35	GO:0035902	response to immobilization stress
0.35	GO:1900273	positive regulation of long-term synaptic potentiation
0.35	GO:0071345	cellular response to cytokine stimulus

0.75	GO:0004725	protein tyrosine phosphatase activity
0.56	GO:0001784	phosphotyrosine residue binding
0.40	GO:0019901	protein kinase binding
0.35	GO:0035254	glutamate receptor binding
0.34	GO:0019198	transmembrane receptor protein phosphatase activity

0.39	GO:0030054	cell junction
0.38	GO:0005829	cytosol
0.36	GO:0005783	endoplasmic reticulum
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.35	GO:0005886	plasma membrane
0.35	GO:0031984	organelle subcompartment
0.35	GO:1990635	proximal dendrite
0.34	GO:0043204	perikaryon
0.34	GO:0005654	nucleoplasm
0.34	GO:0030424	axon

0.75

EC:3.1.3.48

GO:0004725

sp|P54840|GYS2_HUMAN
Glycogen [starch] synthase, liver
Search

GYS2

0.69	Glycogen [starch] synthase

0.76	GO:0005978	glycogen biosynthetic process
0.40	GO:0009749	response to glucose
0.38	GO:0007507	heart development
0.35	GO:0090664	response to high population density
0.34	GO:0032868	response to insulin
0.32	GO:0006310	DNA recombination

0.80	GO:0004373	glycogen (starch) synthase activity
0.39	GO:0019901	protein kinase binding
0.36	GO:0061547	glycogen synthase activity, transferring glucose-1-phosphate
0.35	GO:0005536	glucose binding
0.34	GO:0042803	protein homodimerization activity
0.34	GO:0009011	starch synthase activity
0.33	GO:0070035	purine NTP-dependent helicase activity
0.32	GO:0042623	ATPase activity, coupled
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.41	GO:0043265	ectoplasm
0.39	GO:0016234	inclusion body
0.38	GO:0030864	cortical actin cytoskeleton
0.36	GO:0005829	cytosol

0.80

EC:2.4.1.11

GO:0004373

sp|P54845|NRL_HUMAN
Neural retina-specific leucine zipper protein
Search

NRL

0.88	Leucine zipper transcription factor

0.76	GO:0007468	regulation of rhodopsin gene expression
0.75	GO:0046548	retinal rod cell development
0.59	GO:0006366	transcription by RNA polymerase II
0.58	GO:0045944	positive regulation of transcription by RNA polymerase II
0.43	GO:0070306	lens fiber cell differentiation
0.42	GO:0032330	regulation of chondrocyte differentiation
0.42	GO:0001816	cytokine production
0.41	GO:0048839	inner ear development
0.40	GO:0000122	negative regulation of transcription by RNA polymerase II
0.38	GO:0007263	nitric oxide mediated signal transduction

0.66	GO:0043522	leucine zipper domain binding
0.63	GO:1990841	promoter-specific chromatin binding
0.62	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.60	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.60	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.58	GO:0003713	transcription coactivator activity
0.34	GO:0042803	protein homodimerization activity
0.34	GO:0046982	protein heterodimerization activity
0.32	GO:0003735	structural constituent of ribosome

0.61	GO:0005634	nucleus
0.52	GO:0005829	cytosol
0.52	GO:0031974	membrane-enclosed lumen
0.46	GO:0044446	intracellular organelle part
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0042025	host cell nucleus
0.32	GO:0030529	intracellular ribonucleoprotein complex

sp|P54849|EMP1_HUMAN
Epithelial membrane protein 1
Search

EMP1

0.97	Epithelial membrane protein 1

0.80	GO:0016049	cell growth
0.66	GO:0032060	bleb assembly
0.58	GO:0008219	cell death
0.36	GO:0008544	epidermis development
0.36	GO:0008283	cell proliferation
0.35	GO:0007275	multicellular organism development

0.34

GO:0005515

protein binding

0.45	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

sp|P54851|EMP2_HUMAN
Epithelial membrane protein 2
Search

EMP2

0.97	Epithelial membrane protein 2

0.64	GO:0003093	regulation of glomerular filtration
0.62	GO:0032060	bleb assembly
0.61	GO:0001913	T cell mediated cytotoxicity
0.61	GO:2001212	regulation of vasculogenesis
0.60	GO:2001046	positive regulation of integrin-mediated signaling pathway
0.60	GO:0043534	blood vessel endothelial cell migration
0.60	GO:0034394	protein localization to cell surface
0.59	GO:0045022	early endosome to late endosome transport
0.59	GO:0070252	actin-mediated cell contraction
0.59	GO:0001765	membrane raft assembly

0.57	GO:0005178	integrin binding
0.54	GO:0019901	protein kinase binding

0.56	GO:0016324	apical plasma membrane
0.56	GO:0045121	membrane raft
0.53	GO:0009986	cell surface
0.51	GO:0031410	cytoplasmic vesicle
0.51	GO:0005794	Golgi apparatus
0.49	GO:0005829	cytosol
0.38	GO:0098588	bounding membrane of organelle
0.38	GO:0031984	organelle subcompartment
0.37	GO:0005634	nucleus
0.35	GO:0043218	compact myelin

sp|P54852|EMP3_HUMAN
Epithelial membrane protein 3
Search

EMP3

0.95	Epithelial membrane protein 3

0.71	GO:0016049	cell growth
0.64	GO:0032060	bleb assembly
0.57	GO:0008219	cell death
0.38	GO:0008285	negative regulation of cell proliferation
0.38	GO:0042552	myelination
0.38	GO:0007050	cell cycle arrest
0.37	GO:0010977	negative regulation of neuron projection development
0.35	GO:0007422	peripheral nervous system development
0.35	GO:0010927	cellular component assembly involved in morphogenesis
0.33	GO:0007268	chemical synaptic transmission

0.34

GO:0005515

protein binding

0.45	GO:0005886	plasma membrane
0.38	GO:0043218	compact myelin
0.37	GO:0005923	bicellular tight junction
0.30	GO:0016021	integral component of membrane

sp|P54855|UDB15_HUMAN
UDP-glucuronosyltransferase 2B15
Search

0.54	UDP-glucuronosyltransferase

0.51	GO:0052695	cellular glucuronidation
0.41	GO:0008202	steroid metabolic process
0.38	GO:0006805	xenobiotic metabolic process
0.38	GO:0034754	cellular hormone metabolic process
0.37	GO:0018879	biphenyl metabolic process
0.37	GO:0071394	cellular response to testosterone stimulus
0.36	GO:0071361	cellular response to ethanol
0.36	GO:0071378	cellular response to growth hormone stimulus
0.36	GO:0071385	cellular response to glucocorticoid stimulus
0.36	GO:0032496	response to lipopolysaccharide

0.80	GO:0015020	glucuronosyltransferase activity
0.41	GO:0001972	retinoic acid binding

0.43	GO:0005789	endoplasmic reticulum membrane
0.40	GO:0031090	organelle membrane
0.34	GO:0070062	extracellular exosome
0.34	GO:0005635	nuclear envelope
0.34	GO:0098805	whole membrane
0.33	GO:0019867	outer membrane
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.80

EC:2.4.1.17

GO:0015020

sp|P54868|HMCS2_HUMAN
Hydroxymethylglutaryl-CoA synthase, mitochondrial
Search

HMGCS2

0.67	3-hydroxy-3-methylglutaryl coenzyme A synthase

0.78	GO:0016126	sterol biosynthetic process
0.71	GO:0008299	isoprenoid biosynthetic process
0.45	GO:0014003	oligodendrocyte development
0.35	GO:0033197	response to vitamin E
0.35	GO:0071372	cellular response to follicle-stimulating hormone stimulus
0.35	GO:0071397	cellular response to cholesterol
0.35	GO:0009645	response to low light intensity stimulus
0.35	GO:0071404	cellular response to low-density lipoprotein particle stimulus
0.34	GO:0046690	response to tellurium ion
0.34	GO:0008584	male gonad development

0.83	GO:0004421	hydroxymethylglutaryl-CoA synthase activity
0.34	GO:0008009	chemokine activity
0.34	GO:0042803	protein homodimerization activity
0.33	GO:0043177	organic acid binding
0.33	GO:0016853	isomerase activity
0.32	GO:0008144	drug binding

0.43	GO:0005739	mitochondrion
0.43	GO:0019866	organelle inner membrane
0.33	GO:0005829	cytosol
0.33	GO:0005576	extracellular region

0.83	EC:2.3.3.10	GO:0004421
0.83	KEGG:R01978	GO:0004421

sp|P54886|P5CS_HUMAN
Delta-1-pyrroline-5-carboxylate synthase
Search

ALDH18A1

0.84	Delta-1-pyrroline-5-carboxylate synthase

0.75	GO:0006561	proline biosynthetic process
0.60	GO:0019240	citrulline biosynthetic process
0.57	GO:0006592	ornithine biosynthetic process
0.57	GO:0016310	phosphorylation
0.55	GO:0017144	drug metabolic process
0.52	GO:0055114	oxidation-reduction process
0.50	GO:0006536	glutamate metabolic process
0.34	GO:0016598	protein arginylation
0.34	GO:0009266	response to temperature stimulus

0.79	GO:0004349	glutamate 5-kinase activity
0.79	GO:0004350	glutamate-5-semialdehyde dehydrogenase activity
0.51	GO:0032559	adenyl ribonucleotide binding
0.50	GO:0008144	drug binding
0.50	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0042802	identical protein binding
0.40	GO:0017084	delta1-pyrroline-5-carboxylate synthetase activity
0.35	GO:0050661	NADP binding
0.34	GO:0004057	arginyltransferase activity
0.34	GO:0003723	RNA binding

0.56	GO:0005739	mitochondrion
0.47	GO:0005829	cytosol
0.35	GO:0031967	organelle envelope
0.35	GO:0031090	organelle membrane
0.30	GO:0031224	intrinsic component of membrane

0.79	EC:2.7.2.11	GO:0004349
0.79	KEGG:R00239	GO:0004349

sp|P54920|SNAA_HUMAN
Alpha-soluble NSF attachment protein
Search

NAPA

0.87	N-ethylmaleimide sensitive fusion protein attachment protein alpha

0.68	GO:0006886	intracellular protein transport
0.65	GO:0010807	regulation of synaptic vesicle priming
0.65	GO:0035494	SNARE complex disassembly
0.62	GO:0035249	synaptic transmission, glutamatergic
0.53	GO:0045176	apical protein localization
0.50	GO:0007420	brain development
0.49	GO:0030182	neuron differentiation
0.45	GO:0061025	membrane fusion
0.39	GO:0043462	regulation of ATPase activity
0.38	GO:0051345	positive regulation of hydrolase activity

0.61	GO:0019905	syntaxin binding
0.54	GO:0005483	soluble NSF attachment protein activity
0.38	GO:0032403	protein complex binding
0.32	GO:0003677	DNA binding

0.65	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex
0.59	GO:0043209	myelin sheath
0.48	GO:0005774	vacuolar membrane
0.40	GO:0043195	terminal bouton
0.38	GO:0070062	extracellular exosome
0.35	GO:0005886	plasma membrane
0.34	GO:0000139	Golgi membrane
0.34	GO:0005829	cytosol
0.33	GO:0005634	nucleus

sp|P54922|ADPRH_HUMAN
[Protein ADP-ribosylarginine] hydrolase
Search

ADPRH

0.97	ADP-ribosylarginine hydrolase

0.83	GO:0051725	protein de-ADP-ribosylation
0.50	GO:0031338	regulation of vesicle fusion
0.50	GO:0090630	activation of GTPase activity
0.44	GO:0006886	intracellular protein transport
0.36	GO:0006629	lipid metabolic process

0.84	GO:0003875	ADP-ribosylarginine hydrolase activity
0.60	GO:0000287	magnesium ion binding
0.52	GO:0030955	potassium ion binding
0.49	GO:0017137	Rab GTPase binding
0.47	GO:0005096	GTPase activator activity
0.37	GO:0052689	carboxylic ester hydrolase activity

0.44	GO:0012505	endomembrane system
0.36	GO:0005576	extracellular region
0.36	GO:0005622	intracellular
0.30	GO:0016020	membrane

0.84	EC:3.2.2.19	GO:0003875
0.37	KEGG:R00630	GO:0052689

sp|P55000|SLUR1_HUMAN
Secreted Ly-6/uPAR-related protein 1
Search

SLURP1

0.97	Secreted Ly6/Plaur domain containing 1 (Predicted)

0.86	GO:0038195	urokinase plasminogen activator signaling pathway
0.85	GO:2000273	positive regulation of receptor activity
0.84	GO:0010839	negative regulation of keratinocyte proliferation
0.84	GO:0050884	neuromuscular process controlling posture
0.80	GO:0030336	negative regulation of cell migration
0.77	GO:0007626	locomotory behavior
0.62	GO:0001775	cell activation
0.42	GO:0007155	cell adhesion

0.87	GO:0030549	acetylcholine receptor activator activity
0.49	GO:0005125	cytokine activity

0.71	GO:0005615	extracellular space
0.49	GO:1903561	extracellular vesicle

sp|P55001|MFAP2_HUMAN
Microfibrillar-associated protein 2
Search

MFAP2

0.97	Microfibril-associated glycoprotein 1

0.64	GO:0048048	embryonic eye morphogenesis
0.64	GO:0048050	post-embryonic eye morphogenesis
0.42	GO:0001568	blood vessel development
0.39	GO:0030220	platelet formation
0.36	GO:0030198	extracellular matrix organization
0.36	GO:0060216	definitive hemopoiesis
0.35	GO:0006812	cation transport
0.34	GO:0097435	supramolecular fiber organization
0.34	GO:0006099	tricarboxylic acid cycle
0.33	GO:0022900	electron transport chain

0.39	GO:0070051	fibrinogen binding
0.39	GO:0001968	fibronectin binding
0.35	GO:0016887	ATPase activity
0.35	GO:0051538	3 iron, 4 sulfur cluster binding
0.35	GO:0008177	succinate dehydrogenase (ubiquinone) activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0046872	metal ion binding
0.34	GO:0051537	2 iron, 2 sulfur cluster binding

0.86	GO:0001527	microfibril
0.40	GO:0005578	proteinaceous extracellular matrix
0.34	GO:0005615	extracellular space
0.33	GO:0031966	mitochondrial membrane
0.33	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.35	EC:3.6.1.3	GO:0016887
0.35	KEGG:R02164	GO:0008177

sp|P55008|AIF1_HUMAN
Allograft inflammatory factor 1
Search

AIF1

0.96	Ionized calcium binding adapter molecule 1

0.60	GO:0071673	positive regulation of smooth muscle cell chemotaxis
0.57	GO:0016601	Rac protein signal transduction
0.57	GO:2000406	positive regulation of T cell migration
0.57	GO:0090026	positive regulation of monocyte chemotaxis
0.57	GO:0071672	negative regulation of smooth muscle cell chemotaxis
0.57	GO:0097178	ruffle assembly
0.57	GO:0048661	positive regulation of smooth muscle cell proliferation
0.56	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
0.56	GO:0006911	phagocytosis, engulfment
0.56	GO:0071346	cellular response to interferon-gamma

0.71	GO:0051015	actin filament binding
0.67	GO:0005509	calcium ion binding

0.58	GO:0005884	actin filament
0.57	GO:0032587	ruffle membrane
0.57	GO:0001891	phagocytic cup
0.54	GO:0030027	lamellipodium
0.51	GO:0048471	perinuclear region of cytoplasm
0.48	GO:0005829	cytosol
0.45	GO:0005634	nucleus
0.43	GO:0005925	focal adhesion
0.41	GO:0043204	perikaryon
0.35	GO:0070062	extracellular exosome

sp|P55010|IF5_HUMAN
Eukaryotic translation initiation factor 5
Search

EIF5

0.79	Eukaryotic translation initiation factor

0.72	GO:0006413	translational initiation
0.46	GO:0006446	regulation of translational initiation
0.38	GO:0090630	activation of GTPase activity
0.37	GO:0002181	cytoplasmic translation
0.36	GO:0022618	ribonucleoprotein complex assembly

0.72	GO:0003743	translation initiation factor activity
0.48	GO:0045296	cadherin binding
0.39	GO:0071074	eukaryotic initiation factor eIF2 binding
0.36	GO:0032550	purine ribonucleoside binding
0.36	GO:0019001	guanyl nucleotide binding
0.34	GO:0032555	purine ribonucleotide binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003924	GTPase activity

0.43	GO:0005829	cytosol
0.39	GO:0005886	plasma membrane
0.34	GO:0005634	nucleus

sp|P55011|S12A2_HUMAN
Solute carrier family 12 member 2
Search

SLC12A2

0.75	Bumetanide-sensitive Na-K-Cl cotransporter 1

0.76	GO:1902476	chloride transmembrane transport
0.55	GO:0070634	transepithelial ammonium transport
0.54	GO:0030321	transepithelial chloride transport
0.50	GO:0072488	ammonium transmembrane transport
0.47	GO:0048798	swim bladder inflation
0.44	GO:0042472	inner ear morphogenesis
0.36	GO:0060763	mammary duct terminal end bud growth
0.36	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
0.36	GO:0060444	branching involved in mammary gland duct morphogenesis
0.36	GO:0006814	sodium ion transport

0.84	GO:0015377	cation:chloride symporter activity
0.50	GO:0008519	ammonium transmembrane transporter activity
0.49	GO:0019901	protein kinase binding

0.48	GO:0098590	plasma membrane region
0.45	GO:0045177	apical part of cell
0.32	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane
0.30	GO:0005615	extracellular space
0.30	GO:1903561	extracellular vesicle

sp|P55017|S12A3_HUMAN
Solute carrier family 12 member 3
Search

SLC12A3

0.90	Thiazide-sensitive sodium-chloride cotransporter

0.75	GO:1902476	chloride transmembrane transport
0.52	GO:0006814	sodium ion transport
0.45	GO:0039023	pronephric duct morphogenesis
0.45	GO:0035844	cloaca development
0.36	GO:0055064	chloride ion homeostasis
0.36	GO:0055078	sodium ion homeostasis
0.36	GO:0070293	renal absorption
0.34	GO:0098662	inorganic cation transmembrane transport

0.83	GO:0015377	cation:chloride symporter activity
0.35	GO:0005515	protein binding
0.34	GO:0015081	sodium ion transmembrane transporter activity

0.58	GO:0016324	apical plasma membrane
0.57	GO:0070062	extracellular exosome
0.50	GO:0005829	cytosol
0.34	GO:0005887	integral component of plasma membrane

sp|P55036|PSMD4_HUMAN
26S proteasome non-ATPase regulatory subunit 4
Search

PSMD4

0.89	26S proteasome non-ATPase regulatory subunit 4

0.66	GO:0006511	ubiquitin-dependent protein catabolic process
0.44	GO:0043248	proteasome assembly
0.43	GO:0010498	proteasomal protein catabolic process
0.36	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.36	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.36	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.36	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.36	GO:0038095	Fc-epsilon receptor signaling pathway
0.36	GO:1902036	regulation of hematopoietic stem cell differentiation
0.36	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia

0.45	GO:0031593	polyubiquitin modification-dependent protein binding
0.37	GO:0042802	identical protein binding
0.37	GO:0008134	transcription factor binding
0.34	GO:0003723	RNA binding
0.33	GO:0003735	structural constituent of ribosome

0.75	GO:0008540	proteasome regulatory particle, base subcomplex
0.48	GO:0005829	cytosol
0.47	GO:0005654	nucleoplasm
0.33	GO:0005840	ribosome

sp|P55039|DRG2_HUMAN
Developmentally-regulated GTP-binding protein 2
Search

DRG2

0.97	Developmentally regulated GTP binding protein 2

0.66	GO:0001883	purine nucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.65	GO:0032549	ribonucleoside binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0032555	purine ribonucleotide binding

0.56	GO:0005654	nucleoplasm
0.55	GO:0005829	cytosol
0.50	GO:0005739	mitochondrion

sp|P55040|GEM_HUMAN
GTP-binding protein GEM
Search

GEM

0.46	GTP binding protein overexpressed in skeletal muscle

0.85	GO:1901841	regulation of high voltage-gated calcium channel activity
0.82	GO:1901386	negative regulation of voltage-gated calcium channel activity
0.61	GO:0007165	signal transduction
0.56	GO:0051310	metaphase plate congression
0.51	GO:0000278	mitotic cell cycle
0.47	GO:0051276	chromosome organization
0.35	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.34	GO:0006955	immune response

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0000287	magnesium ion binding
0.42	GO:0005246	calcium channel regulator activity
0.37	GO:0005516	calmodulin binding
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0005509	calcium ion binding

0.56	GO:0051233	spindle midzone
0.55	GO:0030496	midbody
0.54	GO:0072686	mitotic spindle
0.52	GO:0009898	cytoplasmic side of plasma membrane
0.45	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|P55042|RAD_HUMAN
GTP-binding protein RAD
Search

RRAD

0.96	GTP-binding protein RAD

0.86	GO:1901841	regulation of high voltage-gated calcium channel activity
0.81	GO:1901386	negative regulation of voltage-gated calcium channel activity
0.61	GO:0007165	signal transduction
0.46	GO:0051310	metaphase plate congression
0.43	GO:0000278	mitotic cell cycle
0.41	GO:0051276	chromosome organization
0.36	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.35	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
0.35	GO:0030308	negative regulation of cell growth
0.33	GO:0006955	immune response

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0005246	calcium channel regulator activity
0.40	GO:0000287	magnesium ion binding
0.38	GO:0005516	calmodulin binding
0.35	GO:0005509	calcium ion binding

0.46	GO:0051233	spindle midzone
0.45	GO:0030496	midbody
0.45	GO:0072686	mitotic spindle
0.43	GO:0009898	cytoplasmic side of plasma membrane
0.39	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

sp|P55055|NR1H2_HUMAN
Oxysterols receptor LXR-beta
Search

NR1H2

0.92	Nuclear receptor subfamily 1 group H member 2

0.79	GO:0043401	steroid hormone mediated signaling pathway
0.74	GO:0090182	regulation of secretion of lysosomal enzymes
0.74	GO:0010887	negative regulation of cholesterol storage
0.73	GO:0090186	regulation of pancreatic juice secretion
0.72	GO:0010875	positive regulation of cholesterol efflux
0.71	GO:2000188	regulation of cholesterol homeostasis
0.69	GO:0090108	positive regulation of high-density lipoprotein particle assembly
0.68	GO:0048550	negative regulation of pinocytosis
0.68	GO:0042632	cholesterol homeostasis
0.67	GO:0051006	positive regulation of lipoprotein lipase activity

0.80	GO:0003707	steroid hormone receptor activity
0.68	GO:0034191	apolipoprotein A-I receptor binding
0.68	GO:0004879	nuclear receptor activity
0.66	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.66	GO:0046965	retinoid X receptor binding
0.65	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.64	GO:0051117	ATPase binding
0.62	GO:0008270	zinc ion binding

0.61	GO:0005634	nucleus
0.46	GO:0005667	transcription factor complex
0.41	GO:0005737	cytoplasm
0.40	GO:0044446	intracellular organelle part

sp|P55056|APOC4_HUMAN
Apolipoprotein C-IV
Search

APOC4

0.97	Apolipoprotein C-IV

0.72	GO:0006869	lipid transport
0.62	GO:0010890	positive regulation of sequestering of triglyceride
0.59	GO:0070328	triglyceride homeostasis
0.50	GO:0034447	very-low-density lipoprotein particle clearance
0.50	GO:0034379	very-low-density lipoprotein particle assembly
0.40	GO:0006629	lipid metabolic process

0.54

GO:0005319

lipid transporter activity

0.71	GO:0034361	very-low-density lipoprotein particle
0.62	GO:0034364	high-density lipoprotein particle

sp|P55058|PLTP_HUMAN
Phospholipid transfer protein
Search

PLTP

0.97	Lipid transfer protein II

0.62	GO:0010189	vitamin E biosynthetic process
0.62	GO:0006629	lipid metabolic process
0.62	GO:0010875	positive regulation of cholesterol efflux
0.61	GO:0035627	ceramide transport
0.61	GO:0034375	high-density lipoprotein particle remodeling
0.59	GO:0030317	flagellated sperm motility
0.56	GO:0015914	phospholipid transport
0.37	GO:0090108	positive regulation of high-density lipoprotein particle assembly

0.71	GO:0008289	lipid binding
0.63	GO:1904121	phosphatidylethanolamine transporter activity
0.62	GO:0035620	ceramide transporter activity
0.62	GO:0008525	phosphatidylcholine transporter activity
0.62	GO:1990050	phosphatidic acid transporter activity
0.61	GO:0050997	quaternary ammonium group binding
0.57	GO:0070405	ammonium ion binding
0.51	GO:0033218	amide binding
0.42	GO:0043168	anion binding

0.69	GO:0005615	extracellular space
0.59	GO:1990777	lipoprotein particle
0.30	GO:0016020	membrane

sp|P55060|XPO2_HUMAN
Exportin-2
Search

CSE1L

0.75	Exportin-2 (Importin alpha re-exporter)

0.69	GO:0006886	intracellular protein transport
0.54	GO:0007589	body fluid secretion
0.45	GO:0006611	protein export from nucleus
0.44	GO:0006606	protein import into nucleus
0.30	GO:0009987	cellular process
0.30	GO:0008283	cell proliferation

0.77	GO:0008536	Ran GTPase binding
0.46	GO:0005049	nuclear export signal receptor activity

0.58	GO:0005634	nucleus
0.42	GO:0005829	cytosol
0.40	GO:0012505	endomembrane system
0.39	GO:0044446	intracellular organelle part
0.38	GO:0031975	envelope
0.38	GO:0031974	membrane-enclosed lumen
0.37	GO:0009925	basal plasma membrane
0.37	GO:0016328	lateral plasma membrane
0.37	GO:0016324	apical plasma membrane
0.30	GO:0005615	extracellular space

sp|P55061|BI1_HUMAN
Bax inhibitor 1
Search

TMBIM6

0.88	Transmembrane BAX inhibitor motif containing 6

0.70	GO:0043066	negative regulation of apoptotic process
0.59	GO:0031438	negative regulation of mRNA cleavage
0.59	GO:1904720	regulation of mRNA endonucleolytic cleavage involved in unfolded protein response
0.58	GO:1903895	negative regulation of IRE1-mediated unfolded protein response
0.58	GO:0051025	negative regulation of immunoglobulin secretion
0.57	GO:1902065	response to L-glutamate
0.57	GO:1903297	regulation of hypoxia-induced intrinsic apoptotic signaling pathway
0.57	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
0.56	GO:1900038	negative regulation of cellular response to hypoxia
0.55	GO:0033119	negative regulation of RNA splicing

0.54	GO:0060698	endoribonuclease inhibitor activity
0.51	GO:0031625	ubiquitin protein ligase binding

0.49	GO:0005789	endoplasmic reticulum membrane
0.44	GO:0031966	mitochondrial membrane
0.34	GO:0005887	integral component of plasma membrane
0.33	GO:0005634	nucleus

sp|P55064|AQP5_HUMAN
Aquaporin-5
Search

AQP5

0.54	LOW QUALITY PROTEIN: aquaporin-5

0.57	GO:0006833	water transport
0.56	GO:0030157	pancreatic juice secretion
0.56	GO:0015670	carbon dioxide transport
0.55	GO:0055085	transmembrane transport
0.54	GO:0046541	saliva secretion
0.52	GO:0042476	odontogenesis
0.51	GO:0048593	camera-type eye morphogenesis
0.47	GO:0071288	cellular response to mercury ion
0.46	GO:0071280	cellular response to copper ion
0.46	GO:0015793	glycerol transport

0.69	GO:0022803	passive transmembrane transporter activity
0.57	GO:0005372	water transmembrane transporter activity
0.48	GO:0042802	identical protein binding
0.46	GO:0015168	glycerol transmembrane transporter activity
0.34	GO:0030165	PDZ domain binding
0.34	GO:0005179	hormone activity
0.33	GO:0003779	actin binding

0.56	GO:0016324	apical plasma membrane
0.53	GO:0009925	basal plasma membrane
0.52	GO:0005902	microvillus
0.47	GO:0012505	endomembrane system
0.44	GO:0070062	extracellular exosome
0.42	GO:0044444	cytoplasmic part
0.41	GO:0005887	integral component of plasma membrane
0.41	GO:0043231	intracellular membrane-bounded organelle
0.40	GO:0097708	intracellular vesicle
0.37	GO:0012506	vesicle membrane

sp|P55072|TERA_HUMAN
Transitional endoplasmic reticulum ATPase
Search

VCP

0.77	transitional endoplasmic reticulum ATPase

0.59	GO:0061857	endoplasmic reticulum stress-induced pre-emptive quality control
0.58	GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway
0.58	GO:1903007	positive regulation of Lys63-specific deubiquitinase activity
0.58	GO:0042728	flavin-containing compound catabolic process
0.57	GO:0070842	aggresome assembly
0.57	GO:2000158	positive regulation of ubiquitin-specific protease activity
0.56	GO:0034214	protein hexamerization
0.56	GO:0010918	positive regulation of mitochondrial membrane potential
0.56	GO:1903862	positive regulation of oxidative phosphorylation
0.56	GO:0097352	autophagosome maturation

0.57	GO:0035800	deubiquitinase activator activity
0.57	GO:1904288	BAT3 complex binding
0.56	GO:0036435	K48-linked polyubiquitin modification-dependent protein binding
0.56	GO:0042288	MHC class I protein binding
0.56	GO:1990381	ubiquitin-specific protease binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0019903	protein phosphatase binding

0.58	GO:1990730	VCP-NSFL1C complex
0.55	GO:0036513	Derlin-1 retrotranslocation complex
0.55	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex
0.54	GO:0035861	site of double-strand break
0.53	GO:0043209	myelin sheath
0.52	GO:0005811	lipid droplet
0.51	GO:0048471	perinuclear region of cytoplasm
0.48	GO:1905369	endopeptidase complex
0.48	GO:0005829	cytosol
0.48	GO:0005654	nucleoplasm

0.50

GO:0016787

sp|P55073|IOD3_HUMAN
Thyroxine 5-deiodinase
Search

DIO3

0.89	Thyroxine 5-deiodinase

0.76	GO:0042446	hormone biosynthetic process
0.70	GO:0042404	thyroid hormone catabolic process
0.66	GO:0046549	retinal cone cell development
0.63	GO:0040018	positive regulation of multicellular organism growth
0.58	GO:0006915	apoptotic process
0.55	GO:0070342	brown fat cell proliferation
0.53	GO:0055114	oxidation-reduction process
0.51	GO:0006590	thyroid hormone generation
0.48	GO:0001666	response to hypoxia

0.86	GO:0004800	thyroxine 5'-deiodinase activity
0.72	GO:0033798	thyroxine 5-deiodinase activity

0.76	GO:0010008	endosome membrane
0.54	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.86

EC:1.97.1.10

GO:0004800

sp|P55075|FGF8_HUMAN
Fibroblast growth factor 8
Search

FGF8

0.62	Fibroblast growth factor

0.82	GO:0008543	fibroblast growth factor receptor signaling pathway
0.76	GO:0010469	regulation of receptor activity
0.57	GO:0030917	midbrain-hindbrain boundary development
0.57	GO:0030916	otic vesicle formation
0.57	GO:0090133	mesendoderm migration
0.57	GO:0060128	corticotropin hormone secreting cell differentiation
0.56	GO:0030878	thyroid gland development
0.56	GO:0060037	pharyngeal system development
0.56	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation
0.56	GO:0021798	forebrain dorsal/ventral pattern formation

0.83	GO:0005104	fibroblast growth factor receptor binding
0.78	GO:0008083	growth factor activity
0.38	GO:0042056	chemoattractant activity
0.36	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.35	GO:0016303	1-phosphatidylinositol-3-kinase activity
0.35	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.35	GO:0004713	protein tyrosine kinase activity

0.65	GO:0005576	extracellular region
0.39	GO:0005764	lysosome
0.37	GO:0009897	external side of plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.36	EC:2.7.1.153	GO:0046934
0.36	KEGG:R04545	GO:0046934

sp|P55081|MFAP1_HUMAN
Microfibrillar-associated protein 1
Search

MFAP1

0.91	Microfibril associated protein 1

0.86

GO:0001527

microfibril

sp|P55082|MFAP3_HUMAN
Microfibril-associated glycoprotein 3
Search

MFAP3

0.97	LOW QUALITY PROTEIN: microfibril-associated glycoprotein 3

0.32

GO:0005515

protein binding

0.40	GO:0005634	nucleus
0.39	GO:0005886	plasma membrane
0.36	GO:0005737	cytoplasm
0.34	GO:0005576	extracellular region
0.30	GO:0044425	membrane part

sp|P55083|MFAP4_HUMAN
Microfibril-associated glycoprotein 4
Search

MFAP4

0.91	Microfibrillar-associated protein 4 type I

0.76	GO:0071493	cellular response to UV-B
0.76	GO:0009650	UV protection
0.76	GO:0048251	elastic fiber assembly
0.75	GO:0010712	regulation of collagen metabolic process
0.64	GO:0097435	supramolecular fiber organization
0.52	GO:0007155	cell adhesion
0.51	GO:0050767	regulation of neurogenesis
0.39	GO:0000165	MAPK cascade
0.38	GO:0071310	cellular response to organic substance
0.37	GO:0071822	protein complex subunit organization

0.39	GO:0004707	MAP kinase activity
0.36	GO:0005515	protein binding

0.78	GO:0071953	elastic fiber
0.75	GO:0001527	microfibril
0.64	GO:0005615	extracellular space
0.55	GO:0005578	proteinaceous extracellular matrix
0.45	GO:1903561	extracellular vesicle
0.36	GO:0005634	nucleus
0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.39	EC:2.7.11.24	GO:0004707
0.39	KEGG:R00162	GO:0004707

sp|P55084|ECHB_HUMAN
Trifunctional enzyme subunit beta, mitochondrial
Search

HADHB

0.75	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

0.46	GO:0006635	fatty acid beta-oxidation
0.36	GO:0035965	cardiolipin acyl-chain remodeling

0.64	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
0.52	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity
0.36	GO:0004300	enoyl-CoA hydratase activity
0.36	GO:0016508	long-chain-enoyl-CoA hydratase activity
0.34	GO:0000062	fatty-acyl-CoA binding
0.34	GO:0005515	protein binding
0.34	GO:0003723	RNA binding
0.34	GO:0044877	macromolecular complex binding
0.33	GO:0051287	NAD binding

0.51	GO:0042645	mitochondrial nucleoid
0.50	GO:0005741	mitochondrial outer membrane
0.47	GO:0005783	endoplasmic reticulum
0.43	GO:0019866	organelle inner membrane
0.37	GO:0016507	mitochondrial fatty acid beta-oxidation multienzyme complex
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.64

GO:0016747

sp|P55085|PAR2_HUMAN
Proteinase-activated receptor 2
Search

F2RL1

0.97	Protease-activated receptor 2

0.86	GO:0070493	thrombin-activated receptor signaling pathway
0.82	GO:0007596	blood coagulation
0.63	GO:0090195	chemokine secretion
0.63	GO:0097029	mature conventional dendritic cell differentiation
0.63	GO:0035025	positive regulation of Rho protein signal transduction
0.62	GO:1900135	positive regulation of renin secretion into blood stream
0.62	GO:0072643	interferon-gamma secretion
0.61	GO:0072608	interleukin-10 secretion
0.61	GO:0070963	positive regulation of neutrophil mediated killing of gram-negative bacterium
0.61	GO:0090198	negative regulation of chemokine secretion

0.86	GO:0015057	thrombin-activated receptor activity
0.61	GO:0031681	G-protein beta-subunit binding
0.59	GO:0001965	G-protein alpha-subunit binding
0.37	GO:0032795	heterotrimeric G-protein binding
0.36	GO:0005102	receptor binding
0.35	GO:0008233	peptidase activity
0.33	GO:0004435	phosphatidylinositol phospholipase C activity

0.59	GO:0031143	pseudopodium
0.54	GO:0005769	early endosome
0.49	GO:0005887	integral component of plasma membrane
0.40	GO:0098590	plasma membrane region
0.39	GO:0045177	apical part of cell
0.37	GO:0031094	platelet dense tubular network
0.36	GO:0005770	late endosome
0.36	GO:0098857	membrane microdomain
0.35	GO:0043234	protein complex
0.35	GO:0009986	cell surface

0.35	EC:3.4	GO:0008233
0.33	KEGG:R03435	GO:0004435

sp|P55087|AQP4_HUMAN
Aquaporin-4
Search

AQP4

0.95	Aquaporin 4 transcript variant a

0.58	GO:0050891	multicellular organismal water homeostasis
0.57	GO:0071346	cellular response to interferon-gamma
0.55	GO:0055085	transmembrane transport
0.48	GO:0006833	water transport
0.39	GO:0006811	ion transport
0.38	GO:0003014	renal system process
0.36	GO:0007605	sensory perception of sound
0.36	GO:0060354	negative regulation of cell adhesion molecule production
0.35	GO:0015670	carbon dioxide transport
0.35	GO:0032691	negative regulation of interleukin-1 beta production

0.69	GO:0022803	passive transmembrane transporter activity
0.48	GO:0005372	water transmembrane transporter activity
0.36	GO:0042802	identical protein binding
0.34	GO:0008146	sulfotransferase activity

0.55	GO:0009897	external side of plasma membrane
0.46	GO:0016323	basolateral plasma membrane
0.41	GO:0005887	integral component of plasma membrane
0.39	GO:0005737	cytoplasm
0.36	GO:0005911	cell-cell junction
0.36	GO:0046930	pore complex
0.35	GO:0030315	T-tubule
0.35	GO:0045178	basal part of cell
0.35	GO:0031253	cell projection membrane
0.33	GO:0098588	bounding membrane of organelle

0.34

GO:0008146

sp|P55089|UCN1_HUMAN
Urocortin
Search

UCN

0.97

Urocortin

0.77	GO:0051461	positive regulation of corticotropin secretion
0.76	GO:0010469	regulation of receptor activity
0.74	GO:0010996	response to auditory stimulus
0.73	GO:0001964	startle response
0.63	GO:0045944	positive regulation of transcription by RNA polymerase II
0.57	GO:2000252	negative regulation of feeding behavior
0.47	GO:0035483	gastric emptying
0.47	GO:0034199	activation of protein kinase A activity
0.47	GO:2000987	positive regulation of behavioral fear response
0.47	GO:0060455	negative regulation of gastric acid secretion

0.79	GO:0005179	hormone activity
0.48	GO:0046811	histone deacetylase inhibitor activity
0.47	GO:0051430	corticotropin-releasing hormone receptor 1 binding
0.46	GO:0051431	corticotropin-releasing hormone receptor 2 binding

0.66	GO:0005576	extracellular region
0.46	GO:0043196	varicosity
0.44	GO:0043204	perikaryon
0.44	GO:0043679	axon terminus
0.43	GO:0030425	dendrite
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|P55103|INHBC_HUMAN
Inhibin beta C chain
Search

INHBC

0.97	Inhibin beta C subunit

0.76	GO:0010469	regulation of receptor activity
0.54	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.54	GO:0060395	SMAD protein signal transduction
0.50	GO:0043408	regulation of MAPK cascade
0.49	GO:0048468	cell development
0.49	GO:0042981	regulation of apoptotic process
0.35	GO:0032686	negative regulation of hepatocyte growth factor production
0.35	GO:0048176	regulation of hepatocyte growth factor biosynthetic process
0.35	GO:0046882	negative regulation of follicle-stimulating hormone secretion
0.35	GO:0046881	positive regulation of follicle-stimulating hormone secretion

0.78	GO:0008083	growth factor activity
0.76	GO:0005179	hormone activity
0.54	GO:0005160	transforming growth factor beta receptor binding
0.51	GO:0005125	cytokine activity
0.34	GO:0042803	protein homodimerization activity

0.66	GO:0005576	extracellular region
0.38	GO:0031982	vesicle
0.34	GO:0048471	perinuclear region of cytoplasm

sp|P55107|GDF10_HUMAN
Growth/differentiation factor 10
Search

GDF10

0.95	Bone morphogenetic protein 3

0.78	GO:0001649	osteoblast differentiation
0.76	GO:0010469	regulation of receptor activity
0.62	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.59	GO:0045668	negative regulation of osteoblast differentiation
0.58	GO:0045444	fat cell differentiation
0.52	GO:0060395	SMAD protein signal transduction
0.52	GO:0030509	BMP signaling pathway
0.49	GO:0043408	regulation of MAPK cascade
0.48	GO:0048468	cell development
0.47	GO:0042981	regulation of apoptotic process

0.78	GO:0008083	growth factor activity
0.68	GO:0005125	cytokine activity
0.52	GO:0005160	transforming growth factor beta receptor binding
0.50	GO:0070700	BMP receptor binding
0.36	GO:0016015	morphogen activity
0.35	GO:0038100	nodal binding

0.66	GO:0005576	extracellular region
0.34	GO:0031982	vesicle
0.30	GO:0016021	integral component of membrane

sp|P55145|MANF_HUMAN
Mesencephalic astrocyte-derived neurotrophic factor
Search

MANF

0.97	Mesencephalic astrocyte derived neurotrophic factor

0.75	GO:0071542	dopaminergic neuron differentiation
0.61	GO:0031175	neuron projection development
0.46	GO:0006986	response to unfolded protein
0.46	GO:0010469	regulation of receptor activity
0.45	GO:0002014	vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
0.41	GO:0006508	proteolysis
0.41	GO:0007264	small GTPase mediated signal transduction
0.40	GO:0002576	platelet degranulation
0.39	GO:0006886	intracellular protein transport

0.47	GO:0008083	growth factor activity
0.45	GO:0005509	calcium ion binding
0.45	GO:0004222	metalloendopeptidase activity
0.42	GO:0008270	zinc ion binding
0.41	GO:0005085	guanyl-nucleotide exchange factor activity
0.39	GO:0003723	RNA binding

0.59	GO:0005615	extracellular space
0.58	GO:0005783	endoplasmic reticulum
0.43	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0005634	nucleus
0.36	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.45

GO:0004222

sp|P55157|MTP_HUMAN
Microsomal triglyceride transfer protein large subunit
Search

MTTP

0.87	microsomal triglyceride transfer protein large subunit precursor

0.74	GO:0006869	lipid transport
0.56	GO:0042632	cholesterol homeostasis
0.54	GO:0007623	circadian rhythm
0.54	GO:0006641	triglyceride metabolic process
0.53	GO:0042158	lipoprotein biosynthetic process
0.53	GO:0042953	lipoprotein transport
0.44	GO:0036211	protein modification process
0.44	GO:0034377	plasma lipoprotein particle assembly
0.42	GO:0044267	cellular protein metabolic process
0.42	GO:0002040	sprouting angiogenesis

0.76	GO:0005319	lipid transporter activity
0.41	GO:0046982	protein heterodimerization activity
0.40	GO:0034185	apolipoprotein binding
0.39	GO:0008289	lipid binding

0.51	GO:0005783	endoplasmic reticulum
0.40	GO:0031528	microvillus membrane
0.39	GO:0031526	brush border membrane
0.38	GO:0016323	basolateral plasma membrane
0.38	GO:0043235	receptor complex
0.37	GO:0031982	vesicle
0.37	GO:0005794	Golgi apparatus
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|P55160|NCKPL_HUMAN
Nck-associated protein 1-like
Search

NCKAP1L

0.45	Membrane-associated protein HEM-1

0.83	GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation
0.82	GO:0070358	actin polymerization-dependent cell motility
0.81	GO:0045588	positive regulation of gamma-delta T cell differentiation
0.80	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity
0.79	GO:1905155	positive regulation of membrane invagination
0.78	GO:0060099	regulation of phagocytosis, engulfment
0.78	GO:0032700	negative regulation of interleukin-17 production
0.78	GO:0045579	positive regulation of B cell differentiation
0.77	GO:0033630	positive regulation of cell adhesion mediated by integrin
0.77	GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation

0.73	GO:0030295	protein kinase activator activity
0.73	GO:0032403	protein complex binding
0.67	GO:0005096	GTPase activator activity
0.58	GO:0048365	Rac GTPase binding
0.39	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.37	GO:0005248	voltage-gated sodium channel activity
0.36	GO:0022832	voltage-gated channel activity
0.36	GO:0022839	ion gated channel activity
0.36	GO:0008381	mechanosensitive ion channel activity
0.35	GO:0005509	calcium ion binding

0.84	GO:0031209	SCAR complex
0.61	GO:0005829	cytosol
0.47	GO:0031258	lamellipodium membrane
0.44	GO:0070062	extracellular exosome
0.41	GO:0101003	ficolin-1-rich granule membrane
0.41	GO:0031941	filamentous actin
0.40	GO:0001726	ruffle
0.38	GO:0005887	integral component of plasma membrane
0.37	GO:0005925	focal adhesion
0.37	GO:0034706	sodium channel complex

0.39

GO:0004114

sp|P55196|AFAD_HUMAN
Afadin
Search

AFDN

0.93	Afadin, adherens junction formation factor

0.60	GO:0007165	signal transduction
0.53	GO:0034332	adherens junction organization
0.53	GO:0070445	regulation of oligodendrocyte progenitor proliferation
0.52	GO:0060019	radial glial cell differentiation
0.52	GO:1902414	protein localization to cell junction
0.51	GO:0034331	cell junction maintenance
0.51	GO:0048854	brain morphogenesis
0.51	GO:0060563	neuroepithelial cell differentiation
0.50	GO:0021987	cerebral cortex development
0.48	GO:0048872	homeostasis of number of cells

0.51	GO:0050839	cell adhesion molecule binding
0.37	GO:0017016	Ras GTPase binding
0.35	GO:0030274	LIM domain binding
0.35	GO:0008022	protein C-terminus binding
0.34	GO:0003777	microtubule motor activity
0.34	GO:0008017	microtubule binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.77	GO:0005911	cell-cell junction
0.51	GO:0005912	adherens junction
0.50	GO:0016607	nuclear speck
0.48	GO:0045177	apical part of cell
0.46	GO:0005829	cytosol
0.41	GO:0005886	plasma membrane

sp|P55197|AF10_HUMAN
Protein AF-10
Search

MLLT10

0.97	MLLT10, histone lysine methyltransferase DOT1L cofactor

0.64	GO:0045944	positive regulation of transcription by RNA polymerase II
0.43	GO:0060729	intestinal epithelial structure maintenance
0.41	GO:0060070	canonical Wnt signaling pathway

0.54

GO:0046872

metal ion binding

0.60	GO:0005654	nucleoplasm
0.59	GO:0005829	cytosol
0.52	GO:0043234	protein complex

sp|P55198|AF17_HUMAN
Protein AF-17
Search

MLLT6

0.93	Myeloid/lymphoid or mixed-lineage leukemia translocated to, 6

0.69	GO:2001161	negative regulation of histone H3-K79 methylation
0.69	GO:0035812	renal sodium excretion
0.69	GO:0036359	renal potassium excretion
0.68	GO:0035811	negative regulation of urine volume
0.64	GO:0010765	positive regulation of sodium ion transport
0.58	GO:0045944	positive regulation of transcription by RNA polymerase II
0.38	GO:0060729	intestinal epithelial structure maintenance
0.37	GO:0060070	canonical Wnt signaling pathway
0.32	GO:0006351	transcription, DNA-templated

0.54	GO:0046872	metal ion binding
0.38	GO:0051537	2 iron, 2 sulfur cluster binding
0.36	GO:0005515	protein binding
0.32	GO:0003700	DNA binding transcription factor activity
0.32	GO:0003677	DNA binding

0.38	GO:0005654	nucleoplasm
0.38	GO:0005829	cytosol
0.36	GO:0043234	protein complex

sp|P55199|ELL_HUMAN
RNA polymerase II elongation factor ELL
Search

ELL

0.95	RNA polymerase II elongation factor ELL

0.86	GO:0042795	snRNA transcription by RNA polymerase II
0.81	GO:0006368	transcription elongation from RNA polymerase II promoter
0.59	GO:0006414	translational elongation
0.57	GO:0042796	snRNA transcription by RNA polymerase III
0.56	GO:0045945	positive regulation of transcription by RNA polymerase III
0.53	GO:0010923	negative regulation of phosphatase activity
0.53	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
0.51	GO:0001701	in utero embryonic development
0.42	GO:0001570	vasculogenesis

0.59	GO:0003746	translation elongation factor activity
0.53	GO:0019902	phosphatase binding

0.79	GO:0008023	transcription elongation factor complex
0.57	GO:0035363	histone locus body
0.55	GO:0015030	Cajal body
0.55	GO:0035327	transcriptionally active chromatin
0.52	GO:0016607	nuclear speck
0.30	GO:0016020	membrane

sp|P55201|BRPF1_HUMAN
Peregrin
Search

BRPF1

0.93	Bromodomain and PHD finger-containing protein 1

0.62	GO:0043972	histone H3-K23 acetylation
0.52	GO:0045893	positive regulation of transcription, DNA-templated
0.36	GO:1901796	regulation of signal transduction by p53 class mediator
0.35	GO:0009952	anterior/posterior pattern specification
0.34	GO:0006351	transcription, DNA-templated

0.62	GO:0043994	histone acetyltransferase activity (H3-K23 specific)
0.53	GO:0046872	metal ion binding
0.49	GO:0003676	nucleic acid binding
0.34	GO:0005515	protein binding

0.59	GO:0070776	MOZ/MORF histone acetyltransferase complex
0.49	GO:0005829	cytosol
0.43	GO:0005886	plasma membrane
0.34	GO:0000790	nuclear chromatin

sp|P55209|NP1L1_HUMAN
Nucleosome assembly protein 1-like 1
Search

NAP1L1

0.90	Nucleosome assembly protein 1 like 1

0.76	GO:0006334	nucleosome assembly
0.39	GO:0060215	primitive hemopoiesis
0.37	GO:0007283	spermatogenesis
0.37	GO:0030154	cell differentiation
0.37	GO:0051260	protein homooligomerization
0.37	GO:0048522	positive regulation of cellular process
0.36	GO:0010557	positive regulation of macromolecule biosynthetic process
0.36	GO:0010628	positive regulation of gene expression
0.36	GO:0051173	positive regulation of nitrogen compound metabolic process
0.36	GO:0006357	regulation of transcription by RNA polymerase II

0.38	GO:0030332	cyclin binding
0.37	GO:0042393	histone binding
0.34	GO:0019900	kinase binding
0.34	GO:0003723	RNA binding

0.59	GO:0005634	nucleus
0.41	GO:0042470	melanosome
0.34	GO:0043005	neuron projection
0.30	GO:0016020	membrane

sp|P55210|CASP7_HUMAN
Caspase-7
Search

CASP7

0.97	'Caspase 7, apoptosis-related cysteine peptidase'

0.61	GO:0006508	proteolysis
0.59	GO:0097194	execution phase of apoptosis
0.57	GO:0051402	neuron apoptotic process
0.54	GO:0009411	response to UV
0.53	GO:0007507	heart development
0.50	GO:0051604	protein maturation
0.41	GO:0072733	response to staurosporine
0.40	GO:0071312	cellular response to alkaloid
0.40	GO:0048696	regulation of collateral sprouting in absence of injury
0.40	GO:0071236	cellular response to antibiotic

0.75	GO:0004197	cysteine-type endopeptidase activity
0.48	GO:0004190	aspartic-type endopeptidase activity
0.36	GO:0005515	protein binding
0.34	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
0.33	GO:0003735	structural constituent of ribosome

0.38	GO:0005829	cytosol
0.36	GO:0043231	intracellular membrane-bounded organelle
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.34	GO:0044446	intracellular organelle part
0.34	GO:0070013	intracellular organelle lumen
0.33	GO:0031090	organelle membrane
0.33	GO:0031975	envelope
0.33	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

0.75

GO:0004197

sp|P55211|CASP9_HUMAN
Caspase-9
Search

CASP9

0.97	Caspase 9, apoptosis-related cysteine peptidase

0.78	GO:0006915	apoptotic process
0.73	GO:0042981	regulation of apoptotic process
0.61	GO:0006508	proteolysis
0.54	GO:0071549	cellular response to dexamethasone stimulus
0.53	GO:1901216	positive regulation of neuron death
0.52	GO:0042770	signal transduction in response to DNA damage
0.52	GO:0043068	positive regulation of programmed cell death
0.52	GO:0034644	cellular response to UV
0.52	GO:2001056	positive regulation of cysteine-type endopeptidase activity
0.50	GO:2001020	regulation of response to DNA damage stimulus

0.75	GO:0004197	cysteine-type endopeptidase activity
0.50	GO:0017124	SH3 domain binding
0.50	GO:0019901	protein kinase binding
0.36	GO:0042802	identical protein binding
0.36	GO:0008047	enzyme activator activity

0.55	GO:0043293	apoptosome
0.43	GO:0005634	nucleus
0.35	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.75

GO:0004197

sp|P55212|CASP6_HUMAN
Caspase-6
Search

CASP6

0.97	Caspase 6, apoptosis-related cysteine peptidase

0.84	GO:0097194	execution phase of apoptosis
0.61	GO:0006508	proteolysis
0.59	GO:0072733	response to staurosporine
0.57	GO:0071312	cellular response to alkaloid
0.55	GO:0071242	cellular response to ammonium ion
0.52	GO:0030855	epithelial cell differentiation
0.52	GO:0071407	cellular response to organic cyclic compound
0.37	GO:0042981	regulation of apoptotic process
0.37	GO:0002525	acute inflammatory response to non-antigenic stimulus
0.36	GO:0046670	positive regulation of retinal cell programmed cell death

0.85	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis
0.50	GO:0042802	identical protein binding
0.37	GO:0004623	phospholipase A2 activity
0.35	GO:0005509	calcium ion binding
0.35	GO:0005044	scavenger receptor activity
0.34	GO:0004252	serine-type endopeptidase activity

0.48	GO:0005654	nucleoplasm
0.48	GO:0005829	cytosol
0.35	GO:0005576	extracellular region
0.30	GO:0016020	membrane

0.37

EC:3.1.1.4

GO:0004623

sp|P55259|GP2_HUMAN
Pancreatic secretory granule membrane major glycoprotein GP2
Search

UMOD

0.93	Pancreatic zymogen granule membrane protein GP-2

0.54	GO:0072233	metanephric thick ascending limb development
0.53	GO:0072221	metanephric distal convoluted tubule development
0.53	GO:0072021	ascending thin limb development
0.53	GO:0072236	metanephric loop of Henle development
0.51	GO:0007588	excretion
0.51	GO:0007159	leukocyte cell-cell adhesion
0.51	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
0.51	GO:1990266	neutrophil migration
0.49	GO:2000021	regulation of ion homeostasis
0.46	GO:0048878	chemical homeostasis

0.57	GO:0005509	calcium ion binding
0.53	GO:0019864	IgG binding
0.38	GO:0003823	antigen binding
0.35	GO:0051537	2 iron, 2 sulfur cluster binding
0.32	GO:0004222	metalloendopeptidase activity
0.32	GO:0008270	zinc ion binding

0.63	GO:0005576	extracellular region
0.51	GO:0031225	anchored component of membrane
0.51	GO:0016324	apical plasma membrane
0.50	GO:0016323	basolateral plasma membrane
0.49	GO:0000922	spindle pole
0.48	GO:0005929	cilium
0.40	GO:0031253	cell projection membrane
0.38	GO:0098588	bounding membrane of organelle
0.38	GO:0031982	vesicle
0.35	GO:0005796	Golgi lumen

0.32

GO:0004222

sp|P55263|ADK_HUMAN
Adenosine kinase
Search

ADK

0.63	Adenosine kinase a

0.75	GO:0006166	purine ribonucleoside salvage
0.73	GO:0006167	AMP biosynthetic process
0.58	GO:0006175	dATP biosynthetic process
0.53	GO:0016310	phosphorylation
0.49	GO:0046086	adenosine biosynthetic process
0.41	GO:0044262	cellular carbohydrate metabolic process
0.38	GO:0032261	purine nucleotide salvage
0.36	GO:0044342	type B pancreatic cell proliferation
0.35	GO:0010613	positive regulation of cardiac muscle hypertrophy
0.35	GO:0032922	circadian regulation of gene expression

0.84	GO:0004001	adenosine kinase activity
0.43	GO:0019200	carbohydrate kinase activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0046872	metal ion binding
0.34	GO:0003723	RNA binding

0.49	GO:0005829	cytosol
0.47	GO:0005654	nucleoplasm

0.84

EC:2.7.1.20

GO:0004001

sp|P55265|DSRAD_HUMAN
Double-stranded RNA-specific adenosine deaminase
Search

ADAR

0.95	RNA-specific Adenosine deaminase Transcript variant M

0.63	GO:0006396	RNA processing
0.52	GO:1900369	negative regulation of RNA interference
0.51	GO:0061484	hematopoietic stem cell homeostasis
0.51	GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
0.50	GO:0002566	somatic diversification of immune receptors via somatic mutation
0.50	GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA
0.50	GO:0035455	response to interferon-alpha
0.50	GO:0060216	definitive hemopoiesis
0.50	GO:0045070	positive regulation of viral genome replication
0.49	GO:0045071	negative regulation of viral genome replication

0.85	GO:0003726	double-stranded RNA adenosine deaminase activity
0.59	GO:0003723	RNA binding
0.30	GO:0043169	cation binding
0.30	GO:0005515	protein binding
0.30	GO:0003677	DNA binding

0.51	GO:0044530	supraspliceosomal complex
0.45	GO:0005730	nucleolus
0.43	GO:0005654	nucleoplasm
0.37	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|P55268|LAMB2_HUMAN
Laminin subunit beta-2
Search

LAMB1

0.83	Laminin subunit beta 2

0.82	GO:0021812	neuronal-glial interaction involved in cerebral cortex radial glia guided migration
0.75	GO:0034446	substrate adhesion-dependent cell spreading
0.75	GO:0031175	neuron projection development
0.74	GO:0042476	odontogenesis
0.74	GO:0035987	endodermal cell differentiation
0.71	GO:0030335	positive regulation of cell migration
0.62	GO:0072274	metanephric glomerular basement membrane development
0.61	GO:0072313	metanephric glomerular epithelial cell development
0.61	GO:0072248	metanephric glomerular visceral epithelial cell differentiation
0.59	GO:0072015	glomerular visceral epithelial cell development

0.71	GO:0005201	extracellular matrix structural constituent
0.60	GO:0005178	integrin binding
0.48	GO:0043208	glycosphingolipid binding
0.42	GO:0019899	enzyme binding
0.40	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity

0.85	GO:0043256	laminin complex
0.70	GO:0005615	extracellular space
0.58	GO:0043083	synaptic cleft
0.47	GO:0048471	perinuclear region of cytoplasm
0.45	GO:1903561	extracellular vesicle
0.41	GO:0005788	endoplasmic reticulum lumen
0.39	GO:0005634	nucleus

0.40