Queries 5001 to 6000

GO:0004252

sp|P15822|ZEP1_HUMAN
Zinc finger protein 40
Search

HIVEP1

0.91	Human immunodeficiency virus type I enhancer binding protein 1

0.63	GO:0000122	negative regulation of transcription by RNA polymerase II
0.54	GO:0006351	transcription, DNA-templated
0.50	GO:0007275	multicellular organism development
0.45	GO:0007165	signal transduction
0.34	GO:0014706	striated muscle tissue development
0.34	GO:0061061	muscle structure development
0.33	GO:0045893	positive regulation of transcription, DNA-templated
0.33	GO:0030154	cell differentiation

0.72	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
0.63	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.45	GO:0008270	zinc ion binding
0.36	GO:0071837	HMG box domain binding

0.58	GO:0016604	nuclear body
0.48	GO:0005739	mitochondrion

sp|P15848|ARSB_HUMAN
Arylsulfatase B
Search

ARSB

0.89	Arylsulfatase B

0.60	GO:0061580	colon epithelial cell migration
0.54	GO:0010632	regulation of epithelial cell migration
0.42	GO:0010976	positive regulation of neuron projection development
0.41	GO:0051597	response to methylmercury
0.40	GO:0043627	response to estrogen
0.40	GO:0009268	response to pH
0.39	GO:0007584	response to nutrient
0.39	GO:0007417	central nervous system development
0.39	GO:0006914	autophagy
0.36	GO:0030207	chondroitin sulfate catabolic process

0.74	GO:0008484	sulfuric ester hydrolase activity
0.35	GO:0046872	metal ion binding
0.33	GO:0016491	oxidoreductase activity
0.32	GO:0005515	protein binding

0.41	GO:0005764	lysosome
0.40	GO:0009986	cell surface
0.39	GO:0005791	rough endoplasmic reticulum
0.38	GO:0005794	Golgi apparatus
0.37	GO:0005576	extracellular region
0.36	GO:0005788	endoplasmic reticulum lumen
0.36	GO:1904813	ficolin-1-rich granule lumen
0.36	GO:0034774	secretory granule lumen
0.36	GO:0005775	vacuolar lumen
0.36	GO:0005739	mitochondrion

0.74

EC:3.1.6

GO:0008484

sp|P15863|PAX1_HUMAN
Paired box protein Pax-1
Search

PAX1

0.94	PAX-1 PRODUCT=SCLEROTOME development regulator/DNA-binding transcriptional activator

0.70	GO:0007275	multicellular organism development
0.59	GO:0009653	anatomical structure morphogenesis
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0036037	CD8-positive, alpha-beta T cell activation
0.55	GO:0035710	CD4-positive, alpha-beta T cell activation
0.52	GO:0009888	tissue development
0.51	GO:1902680	positive regulation of RNA biosynthetic process

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.52	GO:0001067	regulatory region nucleic acid binding
0.34	GO:0005310	dicarboxylic acid transmembrane transporter activity
0.33	GO:0005249	voltage-gated potassium channel activity

0.61	GO:0005634	nucleus
0.35	GO:0005667	transcription factor complex
0.32	GO:0005743	mitochondrial inner membrane
0.32	GO:0005887	integral component of plasma membrane

sp|P15880|RS2_HUMAN
40S ribosomal protein S2
Search

RPS2

0.50	Ribosomal protein S2

0.59	GO:0006518	peptide metabolic process
0.59	GO:0043604	amide biosynthetic process
0.55	GO:0044267	cellular protein metabolic process
0.53	GO:1901566	organonitrogen compound biosynthetic process
0.53	GO:0010467	gene expression
0.52	GO:0009059	macromolecule biosynthetic process
0.45	GO:0051443	positive regulation of ubiquitin-protein transferase activity
0.42	GO:0071353	cellular response to interleukin-4
0.36	GO:0045471	response to ethanol
0.36	GO:0000028	ribosomal small subunit assembly

0.63	GO:0003735	structural constituent of ribosome
0.59	GO:0003723	RNA binding
0.49	GO:0017134	fibroblast growth factor binding
0.47	GO:0045296	cadherin binding
0.43	GO:0019899	enzyme binding
0.35	GO:0032403	protein complex binding

0.69	GO:0015935	small ribosomal subunit
0.48	GO:0022626	cytosolic ribosome
0.43	GO:0005654	nucleoplasm
0.38	GO:0005925	focal adhesion
0.38	GO:0070062	extracellular exosome
0.36	GO:0005730	nucleolus
0.30	GO:0016020	membrane

sp|P15882|CHIN_HUMAN
N-chimaerin
Search

CHN1

0.86	Beta-chimaerin

0.75	GO:0043547	positive regulation of GTPase activity
0.68	GO:0051056	regulation of small GTPase mediated signal transduction
0.62	GO:0035556	intracellular signal transduction
0.55	GO:0008045	motor neuron axon guidance
0.54	GO:0050770	regulation of axonogenesis
0.43	GO:0021622	oculomotor nerve morphogenesis
0.42	GO:0021603	cranial nerve formation
0.38	GO:0048013	ephrin receptor signaling pathway
0.34	GO:0009967	positive regulation of signal transduction

0.75	GO:0005096	GTPase activator activity
0.55	GO:0046875	ephrin receptor binding
0.53	GO:0046872	metal ion binding
0.44	GO:0001565	phorbol ester receptor activity
0.35	GO:0005070	SH3/SH2 adaptor activity

0.45

GO:0005622

intracellular

sp|P15884|ITF2_HUMAN
Transcription factor 4
Search

TCF4

0.92	Transcription factor 4

0.51	GO:0045666	positive regulation of neuron differentiation
0.51	GO:0042118	endothelial cell activation
0.50	GO:1900746	regulation of vascular endothelial growth factor signaling pathway
0.48	GO:0016525	negative regulation of angiogenesis
0.48	GO:0045944	positive regulation of transcription by RNA polymerase II
0.47	GO:0006367	transcription initiation from RNA polymerase II promoter
0.46	GO:0065004	protein-DNA complex assembly
0.46	GO:0000122	negative regulation of transcription by RNA polymerase II

0.66	GO:0046983	protein dimerization activity
0.53	GO:0001087	transcription factor activity, TFIIB-class binding
0.53	GO:0001011	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting
0.52	GO:0001093	TFIIB-class transcription factor binding
0.51	GO:0070888	E-box binding
0.49	GO:0043621	protein self-association
0.48	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.47	GO:0003714	transcription corepressor activity
0.47	GO:0043425	bHLH transcription factor binding
0.46	GO:0003682	chromatin binding

0.48	GO:0005667	transcription factor complex
0.43	GO:0005634	nucleus
0.36	GO:0000785	chromatin
0.36	GO:0031974	membrane-enclosed lumen
0.34	GO:0032993	protein-DNA complex
0.30	GO:0016020	membrane

sp|P15907|SIAT1_HUMAN
Beta-galactoside alpha-2,6-sialyltransferase 1
Search

ST6GAL1

0.97	Beta-galactoside alpha-2,6-sialyltransferase

0.83	GO:0097503	sialylation
0.74	GO:0043413	macromolecule glycosylation
0.74	GO:0009101	glycoprotein biosynthetic process
0.60	GO:0036211	protein modification process
0.55	GO:0044267	cellular protein metabolic process
0.53	GO:0006054	N-acetylneuraminate metabolic process
0.46	GO:0009311	oligosaccharide metabolic process
0.35	GO:2000110	negative regulation of macrophage apoptotic process
0.35	GO:0006959	humoral immune response
0.35	GO:0050922	negative regulation of chemotaxis

0.83	GO:0008373	sialyltransferase activity
0.33	GO:0005515	protein binding

0.63	GO:0005794	Golgi apparatus
0.44	GO:0098588	bounding membrane of organelle
0.43	GO:0031984	organelle subcompartment
0.36	GO:0070062	extracellular exosome
0.34	GO:0005783	endoplasmic reticulum
0.30	GO:0031224	intrinsic component of membrane

0.83

EC:2.4.99

GO:0008373

sp|P15918|RAG1_HUMAN
V(D)J recombination-activating protein 1
Search

RAG1

0.44	Recombination activating protein 1

0.77	GO:0033151	V(D)J recombination
0.72	GO:0016567	protein ubiquitination
0.63	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.59	GO:0002331	pre-B cell allelic exclusion
0.57	GO:0070244	negative regulation of thymocyte apoptotic process
0.56	GO:0033077	T cell differentiation in thymus
0.55	GO:0043029	T cell homeostasis
0.55	GO:0048538	thymus development
0.55	GO:0045582	positive regulation of T cell differentiation
0.54	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

0.76	GO:0061630	ubiquitin protein ligase activity
0.69	GO:0042803	protein homodimerization activity
0.65	GO:0004519	endonuclease activity
0.64	GO:0043565	sequence-specific DNA binding
0.53	GO:0042393	histone binding
0.47	GO:0046872	metal ion binding

0.58	GO:0005634	nucleus
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part

sp|P15923|TFE2_HUMAN
Transcription factor E2-alpha
Search

TCF3

0.93	Transcription factor 3 variant 3

0.60	GO:0033152	immunoglobulin V(D)J recombination
0.54	GO:0051091	positive regulation of DNA binding transcription factor activity
0.53	GO:0045944	positive regulation of transcription by RNA polymerase II
0.52	GO:0000122	negative regulation of transcription by RNA polymerase II
0.48	GO:0045666	positive regulation of neuron differentiation
0.43	GO:0006351	transcription, DNA-templated
0.43	GO:0002326	B cell lineage commitment
0.41	GO:0030890	positive regulation of B cell proliferation
0.41	GO:2000045	regulation of G1/S transition of mitotic cell cycle
0.40	GO:0045787	positive regulation of cell cycle

0.68	GO:0046983	protein dimerization activity
0.59	GO:0043425	bHLH transcription factor binding
0.59	GO:0070644	vitamin D response element binding
0.58	GO:0031435	mitogen-activated protein kinase kinase kinase binding
0.57	GO:0070888	E-box binding
0.56	GO:0070491	repressing transcription factor binding
0.55	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.53	GO:0003713	transcription coactivator activity
0.52	GO:0042802	identical protein binding
0.40	GO:0035326	enhancer binding

0.53	GO:0005667	transcription factor complex
0.53	GO:0016607	nuclear speck
0.51	GO:0000790	nuclear chromatin
0.39	GO:0005737	cytoplasm
0.36	GO:0000786	nucleosome

sp|P15924|DESP_HUMAN
Desmoplakin
Search

DSP

0.88	Desmoplakin

0.77	GO:0098609	cell-cell adhesion
0.58	GO:0071896	protein localization to adherens junction
0.58	GO:0003223	ventricular compact myocardium morphogenesis
0.58	GO:0086069	bundle of His cell to Purkinje myocyte communication
0.57	GO:0098911	regulation of ventricular cardiac muscle cell action potential
0.57	GO:0002934	desmosome organization
0.57	GO:0045109	intermediate filament organization
0.56	GO:0086091	regulation of heart rate by cardiac conduction
0.55	GO:0030216	keratinocyte differentiation
0.55	GO:0034332	adherens junction organization

0.80	GO:0050839	cell adhesion molecule binding
0.56	GO:0005080	protein kinase C binding
0.56	GO:0097110	scaffold protein binding
0.53	GO:0030674	protein binding, bridging
0.45	GO:0005198	structural molecule activity
0.33	GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
0.33	GO:0004674	protein serine/threonine kinase activity
0.32	GO:0003723	RNA binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.74	GO:0030054	cell junction
0.68	GO:0005856	cytoskeleton
0.56	GO:0001533	cornified envelope
0.54	GO:0016323	basolateral plasma membrane
0.49	GO:0099512	supramolecular fiber
0.43	GO:0044446	intracellular organelle part
0.33	GO:0031012	extracellular matrix
0.33	GO:0070062	extracellular exosome
0.33	GO:0101002	ficolin-1-rich granule
0.33	GO:0070820	tertiary granule

0.33

GO:0004674

sp|P15927|RFA2_HUMAN
Replication protein A 32 kDa subunit
Search

RPA2

0.62	Replication protein A subunit

0.64	GO:0006260	DNA replication
0.63	GO:0006310	DNA recombination
0.63	GO:0006281	DNA repair
0.59	GO:2000001	regulation of DNA damage checkpoint
0.57	GO:0010569	regulation of double-strand break repair via homologous recombination
0.57	GO:0034502	protein localization to chromosome
0.56	GO:0031571	mitotic G1 DNA damage checkpoint
0.54	GO:0000723	telomere maintenance
0.39	GO:0000076	DNA replication checkpoint
0.37	GO:0000082	G1/S transition of mitotic cell cycle

0.58	GO:0098505	G-rich strand telomeric DNA binding
0.55	GO:0019903	protein phosphatase binding
0.53	GO:0031625	ubiquitin protein ligase binding
0.51	GO:0003684	damaged DNA binding
0.41	GO:0047485	protein N-terminus binding

0.60	GO:0005634	nucleus
0.55	GO:0035861	site of double-strand break
0.53	GO:0000781	chromosome, telomeric region
0.52	GO:0030894	replisome
0.51	GO:0000785	chromatin
0.49	GO:0031974	membrane-enclosed lumen
0.45	GO:0043234	protein complex

sp|P15941|MUC1_HUMAN
Mucin-1
Search

MUC1

0.53

Mucin-1

0.46	GO:0090240	positive regulation of histone H4 acetylation
0.46	GO:0033629	negative regulation of cell adhesion mediated by integrin
0.46	GO:0010944	negative regulation of transcription by competitive promoter binding
0.46	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.46	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
0.46	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
0.45	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.44	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress
0.43	GO:0016266	O-glycan processing
0.42	GO:0007155	cell adhesion

0.44	GO:0002039	p53 binding
0.43	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.42	GO:0003712	transcription cofactor activity
0.34	GO:0008201	heparin binding
0.33	GO:0005509	calcium ion binding
0.32	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.32	GO:0004222	metalloendopeptidase activity

0.47	GO:0016324	apical plasma membrane
0.46	GO:0005615	extracellular space
0.44	GO:0005796	Golgi lumen
0.43	GO:1903561	extracellular vesicle
0.42	GO:0000790	nuclear chromatin
0.39	GO:0005887	integral component of plasma membrane
0.37	GO:0009986	cell surface
0.33	GO:0031012	extracellular matrix

0.32

GO:0004222

sp|P15954|COX7C_HUMAN
Cytochrome c oxidase subunit 7C, mitochondrial
Search

COX7C

0.94	Cytochrome c oxidase polypeptide VIIc

0.63	GO:1902600	hydrogen ion transmembrane transport
0.61	GO:0022900	electron transport chain
0.45	GO:0006119	oxidative phosphorylation
0.45	GO:0009060	aerobic respiration

0.65	GO:0015002	heme-copper terminal oxidase activity
0.65	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.62	GO:0009055	electron transfer activity

0.53	GO:0005751	mitochondrial respiratory chain complex IV
0.30	GO:0016021	integral component of membrane

0.65

GO:0016676

sp|P15976|GATA1_HUMAN
Erythroid transcription factor
Search

GATA1

0.87	Erythroid transcription factor

0.80	GO:0030222	eosinophil differentiation
0.79	GO:0030221	basophil differentiation
0.75	GO:0030219	megakaryocyte differentiation
0.74	GO:0048821	erythrocyte development
0.66	GO:0010725	regulation of primitive erythrocyte differentiation
0.65	GO:0010724	regulation of definitive erythrocyte differentiation
0.64	GO:0045648	positive regulation of erythrocyte differentiation
0.64	GO:0071733	transcriptional activation by promoter-enhancer looping
0.63	GO:0030220	platelet formation
0.63	GO:0097067	cellular response to thyroid hormone stimulus

0.65	GO:0070742	C2H2 zinc finger domain binding
0.65	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0001085	RNA polymerase II transcription factor binding
0.61	GO:0035326	enhancer binding
0.61	GO:0003700	DNA binding transcription factor activity
0.60	GO:0008301	DNA binding, bending
0.59	GO:0002039	p53 binding
0.59	GO:0031490	chromatin DNA binding
0.59	GO:0001047	core promoter binding

0.58	GO:0017053	transcriptional repressor complex
0.58	GO:0005634	nucleus
0.56	GO:0005667	transcription factor complex
0.53	GO:0032993	protein-DNA complex
0.39	GO:0070013	intracellular organelle lumen
0.37	GO:0044446	intracellular organelle part

0.35

EC:3.5.1.98

GO:0032041

sp|P16035|TIMP2_HUMAN
Metalloproteinase inhibitor 2
Search

TIMP2

0.92	Tissue inhibitor of metalloproteinase 2

0.75	GO:0010951	negative regulation of endopeptidase activity
0.50	GO:1905049	negative regulation of metallopeptidase activity
0.48	GO:0051045	negative regulation of membrane protein ectodomain proteolysis
0.45	GO:0034097	response to cytokine
0.43	GO:0009725	response to hormone
0.42	GO:0032487	regulation of Rap protein signal transduction
0.42	GO:0030814	regulation of cAMP metabolic process
0.41	GO:0051349	positive regulation of lyase activity
0.41	GO:0031281	positive regulation of cyclase activity
0.41	GO:0045664	regulation of neuron differentiation

0.85	GO:0008191	metalloendopeptidase inhibitor activity
0.50	GO:0002020	protease binding
0.42	GO:0005178	integrin binding
0.41	GO:0008270	zinc ion binding
0.41	GO:0098770	FBXO family protein binding
0.37	GO:0008047	enzyme activator activity
0.35	GO:0008237	metallopeptidase activity

0.65	GO:0005576	extracellular region
0.40	GO:0030426	growth cone
0.40	GO:0009986	cell surface
0.40	GO:0043025	neuronal cell body
0.37	GO:1904724	tertiary granule lumen
0.37	GO:0035580	specific granule lumen
0.37	GO:1904813	ficolin-1-rich granule lumen
0.34	GO:0005634	nucleus

sp|P16050|LOX15_HUMAN
Arachidonate 15-lipoxygenase
Search

ALOX15

0.94	Arachidonate lipoxygenase, epidermal

0.67	GO:0019372	lipoxygenase pathway
0.64	GO:0019369	arachidonic acid metabolic process
0.62	GO:2001303	lipoxin A4 biosynthetic process
0.55	GO:0035963	cellular response to interleukin-13
0.54	GO:0030155	regulation of cell adhesion
0.53	GO:1901751	leukotriene A4 metabolic process
0.53	GO:2001304	lipoxin B4 metabolic process
0.53	GO:0055114	oxidation-reduction process
0.53	GO:0043651	linoleic acid metabolic process
0.52	GO:0071277	cellular response to calcium ion

0.75	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
0.62	GO:0005506	iron ion binding
0.51	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.46	GO:0047977	hepoxilin-epoxide hydrolase activity
0.43	GO:0051120	hepoxilin A3 synthase activity
0.37	GO:0097260	eoxin A4 synthase activity
0.36	GO:0019870	potassium channel inhibitor activity
0.34	GO:0005515	protein binding
0.33	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)

0.50	GO:0005829	cytosol
0.50	GO:0005811	lipid droplet
0.49	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.49	GO:0042383	sarcolemma
0.36	GO:0070062	extracellular exosome
0.32	GO:0005634	nucleus

0.75

EC:1.13.11

GO:0016702

sp|P16066|ANPRA_HUMAN
Atrial natriuretic peptide receptor 1
Search

0.56	Guanylate cyclase

0.82	GO:0006182	cGMP biosynthetic process
0.63	GO:0006468	protein phosphorylation
0.62	GO:0007168	receptor guanylyl cyclase signaling pathway
0.62	GO:0035556	intracellular signal transduction
0.52	GO:1900194	negative regulation of oocyte maturation
0.51	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus
0.49	GO:0051447	negative regulation of meiotic cell cycle
0.49	GO:0060348	bone development
0.45	GO:0022414	reproductive process
0.43	GO:0060038	cardiac muscle cell proliferation

0.82	GO:0004383	guanylate cyclase activity
0.64	GO:0016941	natriuretic peptide receptor activity
0.63	GO:0004672	protein kinase activity
0.60	GO:0017046	peptide hormone binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0004016	adenylate cyclase activity
0.45	GO:0042802	identical protein binding
0.37	GO:0019901	protein kinase binding

0.48	GO:0043235	receptor complex
0.48	GO:0008074	guanylate cyclase complex, soluble
0.43	GO:0005887	integral component of plasma membrane

0.82

GO:0004383

sp|P16070|CD44_HUMAN
CD44 antigen
Search

CD44

0.88	LOW QUALITY PROTEIN: CD44 antigen

0.72	GO:0007155	cell adhesion
0.72	GO:1900625	positive regulation of monocyte aggregation
0.70	GO:2000392	regulation of lamellipodium morphogenesis
0.70	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.70	GO:0034116	positive regulation of heterotypic cell-cell adhesion
0.70	GO:0030214	hyaluronan catabolic process
0.69	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
0.68	GO:0090505	epiboly involved in wound healing
0.66	GO:0033138	positive regulation of peptidyl-serine phosphorylation
0.66	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

0.81	GO:0005540	hyaluronic acid binding
0.64	GO:0004896	cytokine receptor activity
0.42	GO:0005518	collagen binding

0.72	GO:0035692	macrophage migration inhibitory factor receptor complex
0.70	GO:0031258	lamellipodium membrane
0.64	GO:0016324	apical plasma membrane
0.60	GO:0009986	cell surface
0.57	GO:0005794	Golgi apparatus
0.55	GO:0005829	cytosol
0.42	GO:0005902	microvillus
0.42	GO:0030667	secretory granule membrane
0.42	GO:0005925	focal adhesion
0.42	GO:0070062	extracellular exosome

sp|P16083|NQO2_HUMAN
Ribosyldihydronicotinamide dehydrogenase [quinone]
Search

NQO2

0.92	Ribosyldihydronicotinamide dehydrogenase quinone

0.56	GO:0022900	electron transport chain
0.47	GO:0043086	negative regulation of catalytic activity
0.47	GO:0006979	response to oxidative stress
0.45	GO:0043525	positive regulation of neuron apoptotic process
0.44	GO:1904707	positive regulation of vascular smooth muscle cell proliferation
0.43	GO:2000379	positive regulation of reactive oxygen species metabolic process
0.43	GO:0007613	memory
0.43	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.42	GO:0071466	cellular response to xenobiotic stimulus
0.38	GO:1904880	response to hydrogen sulfide

0.85	GO:1905594	resveratrol binding
0.85	GO:1904408	melatonin binding
0.83	GO:0001512	dihydronicotinamide riboside quinone reductase activity
0.79	GO:0031404	chloride ion binding
0.71	GO:0042802	identical protein binding
0.68	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors
0.66	GO:0071949	FAD binding
0.62	GO:0046983	protein dimerization activity
0.58	GO:0008270	zinc ion binding
0.57	GO:0009055	electron transfer activity

0.66	GO:0005829	cytosol
0.63	GO:0005654	nucleoplasm
0.44	GO:0070062	extracellular exosome
0.37	GO:0043025	neuronal cell body
0.36	GO:0030425	dendrite
0.30	GO:0016021	integral component of membrane

0.83

EC:1.10.99.2

GO:0001512

sp|P16104|H2AX_HUMAN
Histone H2AX
Search

sp|P16109|LYAM3_HUMAN
P-selectin
Search

SELP

0.81	Selectin P

0.72	GO:0007155	cell adhesion
0.66	GO:0050900	leukocyte migration
0.61	GO:0033623	regulation of integrin activation
0.61	GO:0010572	positive regulation of platelet activation
0.60	GO:0035584	calcium-mediated signaling using intracellular calcium source
0.59	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
0.57	GO:0002687	positive regulation of leukocyte migration
0.55	GO:0006954	inflammatory response
0.44	GO:0010033	response to organic substance
0.43	GO:0007584	response to nutrient

0.66	GO:0070492	oligosaccharide binding
0.64	GO:0033691	sialic acid binding
0.59	GO:0042806	fucose binding
0.58	GO:0048306	calcium-dependent protein binding
0.57	GO:0008201	heparin binding
0.57	GO:0001530	lipopolysaccharide binding
0.56	GO:0005509	calcium ion binding
0.45	GO:0002020	protease binding
0.42	GO:0050839	cell adhesion molecule binding
0.41	GO:0043274	phospholipase binding

0.62	GO:0031092	platelet alpha granule membrane
0.59	GO:0009897	external side of plasma membrane
0.53	GO:0005615	extracellular space
0.53	GO:0005887	integral component of plasma membrane
0.40	GO:0005901	caveola
0.39	GO:0005905	clathrin-coated pit
0.39	GO:0030863	cortical cytoskeleton
0.39	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0031088	platelet dense granule membrane

0.35

EC:3.1.4

GO:0008081

sp|P16112|PGCA_HUMAN
Aggrecan core protein
Search

ACAN

0.91

Aggrecan

0.72	GO:0007155	cell adhesion
0.63	GO:0001502	cartilage condensation
0.62	GO:0002063	chondrocyte development
0.61	GO:0030199	collagen fibril organization
0.60	GO:0030166	proteoglycan biosynthetic process
0.57	GO:0007507	heart development
0.48	GO:0007417	central nervous system development
0.43	GO:0042340	keratan sulfate catabolic process
0.43	GO:0018146	keratan sulfate biosynthetic process
0.42	GO:0022617	extracellular matrix disassembly

0.84	GO:0005540	hyaluronic acid binding
0.59	GO:0005509	calcium ion binding
0.50	GO:0005201	extracellular matrix structural constituent
0.42	GO:0030246	carbohydrate binding
0.38	GO:0005515	protein binding

0.59	GO:0005578	proteinaceous extracellular matrix
0.58	GO:0044420	extracellular matrix component
0.54	GO:0005615	extracellular space
0.42	GO:0043202	lysosomal lumen
0.42	GO:0005796	Golgi lumen
0.33	GO:0043025	neuronal cell body
0.33	GO:0043005	neuron projection
0.30	GO:0031224	intrinsic component of membrane

sp|P16118|F261_HUMAN
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Search

PFKFB1

0.87	6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1 splice variant 2

0.83	GO:0006003	fructose 2,6-bisphosphate metabolic process
0.83	GO:0006000	fructose metabolic process
0.74	GO:0046835	carbohydrate phosphorylation
0.47	GO:0016311	dephosphorylation
0.41	GO:0033133	positive regulation of glucokinase activity
0.40	GO:0033762	response to glucagon
0.40	GO:0031100	animal organ regeneration
0.39	GO:0051591	response to cAMP
0.39	GO:0051384	response to glucocorticoid
0.39	GO:0032868	response to insulin

0.84	GO:0003873	6-phosphofructo-2-kinase activity
0.56	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0042802	identical protein binding
0.41	GO:0070095	fructose-6-phosphate binding
0.38	GO:0019900	kinase binding
0.35	GO:0003968	RNA-directed 5'-3' RNA polymerase activity

0.56	GO:0043540	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
0.30	GO:0016021	integral component of membrane

0.84	EC:2.7.1.105	GO:0003873
0.84	KEGG:R02732	GO:0003873

sp|P16144|ITB4_HUMAN
Integrin beta-4
Search

ITGB4

0.57	Integrin beta

0.86	GO:0031581	hemidesmosome assembly
0.82	GO:0007160	cell-matrix adhesion
0.80	GO:0007229	integrin-mediated signaling pathway
0.71	GO:0048870	cell motility
0.53	GO:0035878	nail development
0.52	GO:0048333	mesodermal cell differentiation
0.50	GO:0043588	skin development
0.50	GO:0048565	digestive tract development
0.50	GO:0072001	renal system development
0.50	GO:0097186	amelogenesis

0.65	GO:0004872	receptor activity
0.54	GO:0038132	neuregulin binding
0.53	GO:0031994	insulin-like growth factor I binding
0.49	GO:0001664	G-protein coupled receptor binding
0.33	GO:0050839	cell adhesion molecule binding

0.81	GO:0008305	integrin complex
0.53	GO:0030056	hemidesmosome
0.49	GO:0031252	cell leading edge
0.48	GO:0009986	cell surface
0.39	GO:0070062	extracellular exosome
0.34	GO:0009925	basal plasma membrane
0.33	GO:0005604	basement membrane
0.33	GO:0005938	cell cortex

sp|P16150|LEUK_HUMAN
Leukosialin
Search

SPN

0.97	Sialophorin

0.73	GO:0002296	T-helper 1 cell lineage commitment
0.71	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
0.70	GO:0032609	interferon-gamma production
0.62	GO:0042742	defense response to bacterium

0.68

GO:0030544

Hsp70 protein binding

0.60	GO:0009986	cell surface
0.59	GO:0005615	extracellular space
0.30	GO:0016020	membrane

sp|P16152|CBR1_HUMAN
Carbonyl reductase [NADPH] 1
Search

CBR1

0.81	Non-inducible carbony reductase

0.52	GO:0055114	oxidation-reduction process
0.51	GO:0042373	vitamin K metabolic process
0.48	GO:0050890	cognition
0.44	GO:0030855	epithelial cell differentiation
0.41	GO:0042376	phylloquinone catabolic process
0.40	GO:0017144	drug metabolic process
0.37	GO:0006692	prostanoid metabolic process
0.35	GO:1901523	icosanoid catabolic process
0.35	GO:0019369	arachidonic acid metabolic process
0.35	GO:0001542	ovulation from ovarian follicle

0.59	GO:0004090	carbonyl reductase (NADPH) activity
0.47	GO:0070402	NADPH binding
0.46	GO:0047021	15-hydroxyprostaglandin dehydrogenase (NADP+) activity
0.45	GO:0050221	prostaglandin-E2 9-reductase activity
0.41	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
0.39	GO:0000253	3-keto sterol reductase activity
0.35	GO:0005515	protein binding
0.33	GO:0003735	structural constituent of ribosome

0.44	GO:0005654	nucleoplasm
0.44	GO:0005829	cytosol
0.37	GO:0005615	extracellular space
0.36	GO:1903561	extracellular vesicle
0.35	GO:0005902	microvillus
0.33	GO:0005840	ribosome
0.32	GO:0005886	plasma membrane

0.59	EC:1.1.1.184	GO:0004090
0.46	KEGG:R04552	GO:0047021

sp|P16157|ANK1_HUMAN
Ankyrin-1
Search

ANK1

0.77	Ankyrin 1, erythrocytic a

0.60	GO:0007165	signal transduction
0.54	GO:0072659	protein localization to plasma membrane
0.52	GO:0006888	ER to Golgi vesicle-mediated transport
0.37	GO:0010638	positive regulation of organelle organization
0.37	GO:0045199	maintenance of epithelial cell apical/basal polarity
0.36	GO:0048821	erythrocyte development
0.35	GO:0006887	exocytosis
0.35	GO:0055072	iron ion homeostasis
0.35	GO:0007010	cytoskeleton organization
0.34	GO:0006779	porphyrin-containing compound biosynthetic process

0.55	GO:0008093	cytoskeletal adaptor activity
0.55	GO:0051117	ATPase binding
0.55	GO:0030507	spectrin binding
0.35	GO:0005200	structural constituent of cytoskeleton

0.58	GO:0014731	spectrin-associated cytoskeleton
0.42	GO:0005886	plasma membrane
0.40	GO:0016529	sarcoplasmic reticulum
0.39	GO:0031430	M band
0.38	GO:0044304	main axon
0.38	GO:0030018	Z disc
0.38	GO:0031252	cell leading edge
0.37	GO:0098794	postsynapse
0.35	GO:0030863	cortical cytoskeleton
0.35	GO:0005634	nucleus

sp|P16219|ACADS_HUMAN
Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Search

ACADS

0.83	Mitochondrial short-chain specific acyl-CoA dehydrogenase

0.54	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
0.36	GO:0046359	butyrate catabolic process
0.35	GO:0051384	response to glucocorticoid
0.35	GO:0051289	protein homotetramerization
0.35	GO:0006508	proteolysis
0.34	GO:0042594	response to starvation
0.34	GO:0006367	transcription initiation from RNA polymerase II promoter
0.33	GO:0006357	regulation of transcription by RNA polymerase II

0.75	GO:0003995	acyl-CoA dehydrogenase activity
0.66	GO:0050660	flavin adenine dinucleotide binding
0.41	GO:0004085	butyryl-CoA dehydrogenase activity
0.36	GO:0008235	metalloexopeptidase activity
0.36	GO:0030145	manganese ion binding
0.36	GO:0004177	aminopeptidase activity
0.34	GO:0000062	fatty-acyl-CoA binding
0.34	GO:0001104	RNA polymerase II transcription cofactor activity

0.49	GO:0005654	nucleoplasm
0.45	GO:0005739	mitochondrion
0.33	GO:0031967	organelle envelope
0.33	GO:0031090	organelle membrane
0.32	GO:0043234	protein complex

0.75	EC:1.3.99.3	GO:0003995
0.41	KEGG:R01178	GO:0004085

sp|P16220|CREB1_HUMAN
Cyclic AMP-responsive element-binding protein 1
Search

CREB1

0.87	Cyclic AMP-responsive element-binding protein 1

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.49	GO:0033762	response to glucagon
0.49	GO:0060509	Type I pneumocyte differentiation
0.49	GO:0060430	lung saccule development
0.48	GO:0045600	positive regulation of fat cell differentiation
0.48	GO:0071294	cellular response to zinc ion
0.48	GO:0035729	cellular response to hepatocyte growth factor stimulus
0.48	GO:0046889	positive regulation of lipid biosynthetic process

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.47	GO:0001102	RNA polymerase II activating transcription factor binding
0.47	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.44	GO:0001225	RNA polymerase II transcription coactivator binding
0.44	GO:0001067	regulatory region nucleic acid binding
0.44	GO:1990763	arrestin family protein binding
0.43	GO:0042802	identical protein binding
0.43	GO:0035035	histone acetyltransferase binding
0.43	GO:0030544	Hsp70 protein binding

0.61	GO:0005634	nucleus
0.47	GO:0000791	euchromatin
0.44	GO:0005667	transcription factor complex
0.42	GO:0070013	intracellular organelle lumen
0.41	GO:0030424	axon
0.37	GO:0044429	mitochondrial part

sp|P16233|LIPP_HUMAN
Pancreatic triacylglycerol lipase
Search

0.59	Pancreatic triacylglycerol lipase

0.70	GO:0016042	lipid catabolic process
0.59	GO:0007586	digestion
0.56	GO:0061365	positive regulation of triglyceride lipase activity
0.54	GO:0030301	cholesterol transport
0.50	GO:0006968	cellular defense response
0.48	GO:0003008	system process
0.36	GO:0042750	hibernation
0.36	GO:0001523	retinoid metabolic process
0.35	GO:0043434	response to peptide hormone
0.34	GO:0009791	post-embryonic development

0.78	GO:0004806	triglyceride lipase activity
0.36	GO:0046872	metal ion binding

0.65	GO:0005576	extracellular region
0.30	GO:0044425	membrane part

0.78

EC:3.1.1.3

GO:0004806

sp|P16234|PGFRA_HUMAN
Platelet-derived growth factor receptor alpha
Search

PDGFRA

0.68	Platelet-derived growth factor receptor alpha

0.85	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway
0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.65	GO:0006935	chemotaxis
0.64	GO:0007275	multicellular organism development
0.59	GO:0023019	signal transduction involved in regulation of gene expression
0.59	GO:0008210	estrogen metabolic process
0.58	GO:0060325	face morphogenesis
0.58	GO:0022602	ovulation cycle process
0.57	GO:0060021	palate development
0.57	GO:1904888	cranial skeletal system development

0.85	GO:0005018	platelet-derived growth factor alpha-receptor activity
0.60	GO:0048407	platelet-derived growth factor binding
0.54	GO:0038085	vascular endothelial growth factor binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0005161	platelet-derived growth factor receptor binding
0.52	GO:0032403	protein complex binding
0.52	GO:0005021	vascular endothelial growth factor-activated receptor activity

0.57	GO:0005902	microvillus
0.55	GO:0009897	external side of plasma membrane
0.47	GO:0030054	cell junction
0.46	GO:0005634	nucleus
0.44	GO:0031226	intrinsic component of plasma membrane
0.41	GO:0043234	protein complex
0.40	GO:0005737	cytoplasm
0.40	GO:0070013	intracellular organelle lumen
0.37	GO:0044446	intracellular organelle part
0.35	GO:0030424	axon

0.36	EC:2.7.1.153	GO:0046934
0.36	KEGG:R04545	GO:0046934

sp|P16260|GDC_HUMAN
Graves disease carrier protein
Search

SLC25A16

0.89	Graves disease carrier protein homolog

0.54	GO:0055085	transmembrane transport
0.45	GO:0006839	mitochondrial transport
0.35	GO:0006264	mitochondrial DNA replication
0.35	GO:0043504	mitochondrial DNA repair
0.35	GO:0000729	DNA double-strand break processing
0.35	GO:0045740	positive regulation of DNA replication
0.35	GO:0000076	DNA replication checkpoint
0.35	GO:0043137	DNA replication, removal of RNA primer
0.34	GO:0009108	coenzyme biosynthetic process
0.34	GO:0006284	base-excision repair

0.39	GO:0022857	transmembrane transporter activity
0.36	GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base
0.35	GO:0043142	single-stranded DNA-dependent ATPase activity
0.35	GO:0017108	5'-flap endonuclease activity
0.35	GO:0043139	5'-3' DNA helicase activity
0.33	GO:0003677	DNA binding

0.61	GO:0031966	mitochondrial membrane
0.61	GO:0019866	organelle inner membrane
0.35	GO:0005760	gamma DNA polymerase complex
0.35	GO:0042645	mitochondrial nucleoid
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.36

EC:3.1.25

GO:0016890

sp|P16278|BGAL_HUMAN
Beta-galactosidase
Search

GLB1

0.40	Beta-galactosidase

0.60	GO:0005975	carbohydrate metabolic process
0.42	GO:0051413	response to cortisone
0.41	GO:1904016	response to Thyroglobulin triiodothyronine
0.37	GO:0042340	keratan sulfate catabolic process
0.36	GO:0044282	small molecule catabolic process
0.36	GO:0043312	neutrophil degranulation
0.35	GO:0006687	glycosphingolipid metabolic process

0.77	GO:0004565	beta-galactosidase activity
0.41	GO:0016936	galactoside binding
0.34	GO:0004308	exo-alpha-sialidase activity
0.33	GO:0005515	protein binding

0.48	GO:0005615	extracellular space
0.48	GO:0005794	Golgi apparatus
0.46	GO:0005773	vacuole
0.37	GO:1903561	extracellular vesicle
0.36	GO:1904813	ficolin-1-rich granule lumen
0.36	GO:0034774	secretory granule lumen
0.35	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.77

EC:3.2.1.23

GO:0004565

sp|P16284|PECA1_HUMAN
Platelet endothelial cell adhesion molecule
Search

PECAM1

0.95	Platelet endothelial cell adhesion molecule

0.68	GO:0090673	endothelial cell-matrix adhesion
0.66	GO:0001886	endothelial cell morphogenesis
0.64	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
0.63	GO:0043542	endothelial cell migration
0.62	GO:0007266	Rho protein signal transduction
0.60	GO:0001568	blood vessel development
0.59	GO:0042060	wound healing
0.59	GO:0030334	regulation of cell migration
0.56	GO:0048646	anatomical structure formation involved in morphogenesis
0.44	GO:0050904	diapedesis

0.40	GO:0042803	protein homodimerization activity
0.36	GO:0019903	protein phosphatase binding
0.33	GO:0005509	calcium ion binding
0.32	GO:0004672	protein kinase activity
0.31	GO:0030554	adenyl nucleotide binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding
0.31	GO:0032555	purine ribonucleotide binding
0.31	GO:0008144	drug binding

0.66	GO:0030485	smooth muscle contractile fiber
0.62	GO:0098857	membrane microdomain
0.60	GO:0009897	external side of plasma membrane
0.43	GO:0030054	cell junction
0.40	GO:0070062	extracellular exosome
0.39	GO:0031092	platelet alpha granule membrane
0.36	GO:0001726	ruffle
0.32	GO:0005604	basement membrane
0.32	GO:0005938	cell cortex
0.30	GO:0016021	integral component of membrane

sp|P16298|PP2BB_HUMAN
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Search

PPP3CB

0.50	Serine/threonine-protein phosphatase

0.71	GO:0006470	protein dephosphorylation
0.57	GO:0001915	negative regulation of T cell mediated cytotoxicity
0.56	GO:0031987	locomotion involved in locomotory behavior
0.56	GO:0035690	cellular response to drug
0.56	GO:0033173	calcineurin-NFAT signaling cascade
0.55	GO:0001946	lymphangiogenesis
0.55	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
0.55	GO:0043029	T cell homeostasis
0.54	GO:0035176	social behavior
0.53	GO:0030217	T cell differentiation

0.72	GO:0004721	phosphoprotein phosphatase activity
0.62	GO:0030346	protein phosphatase 2B binding
0.55	GO:0005516	calmodulin binding
0.51	GO:0005509	calcium ion binding
0.46	GO:0046983	protein dimerization activity
0.42	GO:0008144	drug binding
0.35	GO:0019855	calcium channel inhibitor activity

0.62	GO:0005955	calcineurin complex
0.55	GO:0030315	T-tubule
0.53	GO:0030018	Z disc
0.36	GO:0005829	cytosol
0.35	GO:0043204	perikaryon
0.34	GO:0030424	axon
0.34	GO:0005654	nucleoplasm
0.33	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

0.72

EC:3.1.3.16

GO:0004721

sp|P16333|NCK1_HUMAN
Cytoplasmic protein NCK1
Search

NCK1

0.91	NCK adaptor protein 1

0.77	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress
0.77	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
0.77	GO:1903898	negative regulation of PERK-mediated unfolded protein response
0.76	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
0.76	GO:0009967	positive regulation of signal transduction
0.73	GO:1902235	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.73	GO:1905898	positive regulation of response to endoplasmic reticulum stress
0.72	GO:0033137	negative regulation of peptidyl-serine phosphorylation
0.71	GO:0030032	lamellipodium assembly
0.70	GO:0042102	positive regulation of T cell proliferation

0.85	GO:0005070	SH3/SH2 adaptor activity
0.65	GO:0071074	eukaryotic initiation factor eIF2 binding
0.59	GO:0030971	receptor tyrosine kinase binding
0.59	GO:0097110	scaffold protein binding
0.59	GO:0046875	ephrin receptor binding
0.58	GO:0001784	phosphotyrosine residue binding
0.58	GO:0004860	protein kinase inhibitor activity
0.57	GO:0045296	cadherin binding
0.54	GO:0019904	protein domain specific binding
0.53	GO:0032403	protein complex binding

0.63	GO:0012506	vesicle membrane
0.59	GO:0005783	endoplasmic reticulum
0.58	GO:0000164	protein phosphatase type 1 complex
0.54	GO:0005911	cell-cell junction
0.46	GO:0005840	ribosome
0.36	GO:0014069	postsynaptic density

sp|P16383|GCFC2_HUMAN
GC-rich sequence DNA-binding factor 2
Search

sp|P16389|KCNA2_HUMAN
Potassium voltage-gated channel subfamily A member 2
Search

KCNA2

0.97	Potassium voltage-gated channel subfamily A member 2

0.77	GO:0051260	protein homooligomerization
0.77	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.58	GO:0021633	optic nerve structural organization
0.56	GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep
0.55	GO:0014059	regulation of dopamine secretion
0.49	GO:0019228	neuronal action potential
0.48	GO:0019233	sensory perception of pain
0.47	GO:0071286	cellular response to magnesium ion
0.46	GO:0050976	detection of mechanical stimulus involved in sensory perception of touch

0.78	GO:0005249	voltage-gated potassium channel activity
0.45	GO:0097718	disordered domain specific binding
0.38	GO:0019894	kinesin binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.61	GO:0044224	juxtaparanode region of axon
0.57	GO:0043679	axon terminus
0.55	GO:0043025	neuronal cell body
0.55	GO:0044298	cell body membrane
0.55	GO:0030425	dendrite
0.46	GO:0033270	paranode region of axon
0.44	GO:0030054	cell junction
0.42	GO:0009986	cell surface
0.41	GO:0042734	presynaptic membrane

sp|P16401|H15_HUMAN
Histone H1.5
Search

0.97	Histone cluster 1 H1 family member b

0.79	GO:0006334	nucleosome assembly
0.54	GO:0098532	histone H3-K27 trimethylation
0.53	GO:0000122	negative regulation of transcription by RNA polymerase II
0.52	GO:0080182	histone H3-K4 trimethylation
0.51	GO:0016584	nucleosome positioning
0.49	GO:0071169	establishment of protein localization to chromatin
0.49	GO:0051574	positive regulation of histone H3-K9 methylation
0.47	GO:0030307	positive regulation of cell growth
0.46	GO:0050821	protein stabilization
0.36	GO:0007517	muscle organ development

0.63	GO:0031490	chromatin DNA binding
0.47	GO:0042826	histone deacetylase binding
0.41	GO:0032564	dATP binding
0.38	GO:0016208	AMP binding
0.37	GO:0043531	ADP binding
0.37	GO:0003690	double-stranded DNA binding
0.37	GO:0003723	RNA binding
0.36	GO:0005509	calcium ion binding
0.36	GO:0032550	purine ribonucleoside binding
0.36	GO:0032561	guanyl ribonucleotide binding

0.75	GO:0000786	nucleosome
0.61	GO:0005634	nucleus
0.54	GO:0000792	heterochromatin
0.53	GO:0031974	membrane-enclosed lumen
0.53	GO:0000791	euchromatin
0.44	GO:0035327	transcriptionally active chromatin
0.39	GO:0070062	extracellular exosome
0.35	GO:0009986	cell surface

sp|P16402|H13_HUMAN
Histone H1.3
Search

0.97	Histone cluster 1 H1 family member d

0.79	GO:0006334	nucleosome assembly
0.56	GO:0098532	histone H3-K27 trimethylation
0.55	GO:0080182	histone H3-K4 trimethylation
0.54	GO:0016584	nucleosome positioning
0.54	GO:0000122	negative regulation of transcription by RNA polymerase II
0.46	GO:0071169	establishment of protein localization to chromatin
0.46	GO:0051574	positive regulation of histone H3-K9 methylation
0.44	GO:0030307	positive regulation of cell growth
0.43	GO:0050821	protein stabilization
0.42	GO:0048260	positive regulation of receptor-mediated endocytosis

0.66	GO:0031490	chromatin DNA binding
0.45	GO:0042826	histone deacetylase binding
0.41	GO:0008201	heparin binding
0.41	GO:0032564	dATP binding
0.38	GO:0016208	AMP binding
0.37	GO:0043531	ADP binding
0.37	GO:0003690	double-stranded DNA binding
0.36	GO:0005509	calcium ion binding
0.36	GO:0003723	RNA binding
0.36	GO:0032550	purine ribonucleoside binding

0.75	GO:0000786	nucleosome
0.61	GO:0005634	nucleus
0.59	GO:0000791	euchromatin
0.55	GO:0031974	membrane-enclosed lumen
0.52	GO:0000792	heterochromatin
0.48	GO:0035327	transcriptionally active chromatin
0.41	GO:0031982	vesicle
0.40	GO:0009986	cell surface
0.37	GO:0043230	extracellular organelle
0.36	GO:0005615	extracellular space

sp|P16403|H12_HUMAN
Histone H1.2
Search

0.97	Histone cluster 1 H1 family member c

0.79	GO:0006334	nucleosome assembly
0.58	GO:0098532	histone H3-K27 trimethylation
0.56	GO:0080182	histone H3-K4 trimethylation
0.55	GO:0016584	nucleosome positioning
0.55	GO:0000122	negative regulation of transcription by RNA polymerase II
0.46	GO:0071169	establishment of protein localization to chromatin
0.46	GO:0051574	positive regulation of histone H3-K9 methylation
0.44	GO:0030307	positive regulation of cell growth
0.43	GO:0050821	protein stabilization
0.41	GO:0048260	positive regulation of receptor-mediated endocytosis

0.65	GO:0031490	chromatin DNA binding
0.45	GO:0042826	histone deacetylase binding
0.41	GO:0032564	dATP binding
0.40	GO:0008201	heparin binding
0.38	GO:0016208	AMP binding
0.37	GO:0043531	ADP binding
0.37	GO:0003690	double-stranded DNA binding
0.37	GO:0003723	RNA binding
0.36	GO:0005509	calcium ion binding
0.36	GO:0032550	purine ribonucleoside binding

0.75	GO:0000786	nucleosome
0.61	GO:0005634	nucleus
0.58	GO:0000791	euchromatin
0.55	GO:0031974	membrane-enclosed lumen
0.52	GO:0000792	heterochromatin
0.49	GO:0035327	transcriptionally active chromatin
0.40	GO:0031982	vesicle
0.39	GO:0009986	cell surface
0.38	GO:0043230	extracellular organelle
0.37	GO:0005615	extracellular space

sp|P16410|CTLA4_HUMAN
Cytotoxic T-lymphocyte protein 4
Search

CTLA4

0.97	Soluble form of cytotoxic T-lymphocyte antigen 4

0.74	GO:0006955	immune response
0.70	GO:0045590	negative regulation of regulatory T cell differentiation
0.67	GO:0030889	negative regulation of B cell proliferation
0.65	GO:0050853	B cell receptor signaling pathway
0.60	GO:0043065	positive regulation of apoptotic process
0.52	GO:0006974	cellular response to DNA damage stimulus
0.43	GO:0042130	negative regulation of T cell proliferation
0.40	GO:0050777	negative regulation of immune response
0.37	GO:0031295	T cell costimulation

0.37	GO:0005515	protein binding
0.36	GO:0004872	receptor activity

0.64	GO:0045334	clathrin-coated endocytic vesicle
0.62	GO:0009897	external side of plasma membrane
0.62	GO:0098636	protein complex involved in cell adhesion
0.61	GO:0048471	perinuclear region of cytoplasm
0.56	GO:0005794	Golgi apparatus
0.54	GO:0005887	integral component of plasma membrane

sp|P16415|ZN823_HUMAN
Zinc finger protein 823
Search

0.84	Zinc finger protein 35

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.38	GO:0006351	transcription, DNA-templated
0.37	GO:0071300	cellular response to retinoic acid
0.36	GO:0007283	spermatogenesis
0.33	GO:0071222	cellular response to lipopolysaccharide
0.32	GO:0034605	cellular response to heat

0.51	GO:0003676	nucleic acid binding
0.51	GO:0046872	metal ion binding
0.43	GO:0003700	DNA binding transcription factor activity
0.33	GO:0005515	protein binding

0.49	GO:0048471	perinuclear region of cytoplasm
0.45	GO:0005634	nucleus
0.31	GO:0005886	plasma membrane

sp|P16422|EPCAM_HUMAN
Epithelial cell adhesion molecule
Search

EPCAM

0.96	Epithelial cell adhesion molecule

0.56	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin
0.55	GO:0023019	signal transduction involved in regulation of gene expression
0.55	GO:0001657	ureteric bud development
0.54	GO:2000648	positive regulation of stem cell proliferation
0.52	GO:0048863	stem cell differentiation
0.49	GO:0098609	cell-cell adhesion
0.49	GO:0045944	positive regulation of transcription by RNA polymerase II
0.44	GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis
0.43	GO:1900028	negative regulation of ruffle assembly
0.43	GO:2000738	positive regulation of stem cell differentiation

0.50	GO:0098641	cadherin binding involved in cell-cell adhesion
0.49	GO:0032403	protein complex binding
0.34	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.33	GO:0030983	mismatched DNA binding
0.33	GO:0004222	metalloendopeptidase activity
0.33	GO:0004872	receptor activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.57	GO:0016328	lateral plasma membrane
0.56	GO:0016323	basolateral plasma membrane
0.54	GO:0005923	bicellular tight junction
0.51	GO:0016324	apical plasma membrane
0.49	GO:0009986	cell surface
0.44	GO:0005887	integral component of plasma membrane
0.42	GO:0045178	basal part of cell
0.41	GO:0005615	extracellular space
0.38	GO:0048471	perinuclear region of cytoplasm
0.38	GO:1903561	extracellular vesicle

0.33

GO:0004222

sp|P16435|NCPR_HUMAN
NADPH--cytochrome P450 reductase
Search

POR

0.66	NADPH--cytochrome P450 reductase

0.55	GO:0090345	cellular organohalogen metabolic process
0.53	GO:0032770	positive regulation of monooxygenase activity
0.52	GO:0055114	oxidation-reduction process
0.40	GO:0043602	nitrate catabolic process
0.40	GO:0003420	regulation of growth plate cartilage chondrocyte proliferation
0.39	GO:0046210	nitric oxide catabolic process
0.39	GO:0045542	positive regulation of cholesterol biosynthetic process
0.39	GO:0090031	positive regulation of steroid hormone biosynthetic process
0.39	GO:0071372	cellular response to follicle-stimulating hormone stimulus
0.39	GO:0060192	negative regulation of lipase activity

0.81	GO:0003958	NADPH-hemoprotein reductase activity
0.69	GO:0010181	FMN binding
0.64	GO:0050661	NADP binding
0.61	GO:0050660	flavin adenine dinucleotide binding
0.40	GO:0047726	iron-cytochrome-c reductase activity
0.38	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H
0.38	GO:0008941	nitric oxide dioxygenase activity
0.36	GO:0019899	enzyme binding
0.35	GO:0009055	electron transfer activity
0.34	GO:0016787	hydrolase activity

0.67	GO:0005789	endoplasmic reticulum membrane
0.35	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.81

EC:1.6.2.4

GO:0003958

sp|P16442|BGAT_HUMAN
Histo-blood group ABO system transferase
Search

ABO

0.84	Histo-blood group ABO system transferase

0.60	GO:0005975	carbohydrate metabolic process
0.37	GO:0030259	lipid glycosylation
0.36	GO:0009247	glycolipid biosynthetic process
0.34	GO:0006486	protein glycosylation

0.69	GO:0016758	transferase activity, transferring hexosyl groups
0.42	GO:0140103	catalytic activity, acting on a glycoprotein
0.42	GO:0008194	UDP-glycosyltransferase activity
0.37	GO:0003823	antigen binding
0.35	GO:0030145	manganese ion binding
0.33	GO:0005515	protein binding
0.33	GO:1901265	nucleoside phosphate binding
0.33	GO:0036094	small molecule binding

0.36	GO:0031982	vesicle
0.36	GO:0005794	Golgi apparatus
0.34	GO:0098588	bounding membrane of organelle
0.33	GO:0031984	organelle subcompartment
0.33	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

0.69

GO:0016758

sp|P16444|DPEP1_HUMAN
Dipeptidase 1
Search

DPEP1

0.58	Dipeptidase

0.60	GO:0006508	proteolysis
0.59	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.58	GO:0030336	negative regulation of cell migration
0.58	GO:0050667	homocysteine metabolic process
0.57	GO:0035690	cellular response to drug
0.55	GO:0006915	apoptotic process
0.55	GO:0016999	antibiotic metabolic process
0.44	GO:0071731	response to nitric oxide
0.44	GO:1902170	cellular response to reactive nitrogen species
0.44	GO:0071277	cellular response to calcium ion

0.77	GO:0016805	dipeptidase activity
0.76	GO:0008239	dipeptidyl-peptidase activity
0.71	GO:0008235	metalloexopeptidase activity
0.61	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.54	GO:0046872	metal ion binding
0.54	GO:0072341	modified amino acid binding
0.45	GO:0034235	GPI anchor binding
0.34	GO:0005515	protein binding

0.79	GO:0031225	anchored component of membrane
0.57	GO:0045177	apical part of cell
0.52	GO:0030054	cell junction
0.45	GO:0005634	nucleus
0.44	GO:0005886	plasma membrane
0.42	GO:0005902	microvillus
0.41	GO:0005615	extracellular space
0.40	GO:0120038	plasma membrane bounded cell projection part
0.37	GO:1903561	extracellular vesicle
0.34	GO:0005789	endoplasmic reticulum membrane

0.77

EC:3.4.13

GO:0016805

sp|P16452|EPB42_HUMAN
Erythrocyte membrane protein band 4.2
Search

EPB42

0.95	Erythrocyte membrane protein band 4.2

0.84	GO:0018149	peptide cross-linking
0.60	GO:0020027	hemoglobin metabolic process
0.59	GO:0048536	spleen development
0.56	GO:0055065	metal ion homeostasis
0.55	GO:0009653	anatomical structure morphogenesis
0.51	GO:0048869	cellular developmental process
0.48	GO:0043277	apoptotic cell clearance
0.48	GO:0007431	salivary gland development
0.46	GO:0072503	cellular divalent inorganic cation homeostasis
0.46	GO:0043065	positive regulation of apoptotic process

0.84	GO:0003810	protein-glutamine gamma-glutamyltransferase activity
0.36	GO:0005515	protein binding
0.36	GO:0005200	structural constituent of cytoskeleton
0.34	GO:0046872	metal ion binding
0.34	GO:0032550	purine ribonucleoside binding
0.34	GO:0032561	guanyl ribonucleotide binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0008483	transaminase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding

0.55	GO:0030863	cortical cytoskeleton
0.43	GO:0005783	endoplasmic reticulum
0.42	GO:0005829	cytosol
0.42	GO:0031226	intrinsic component of plasma membrane
0.40	GO:0005739	mitochondrion
0.35	GO:0005925	focal adhesion
0.35	GO:0070062	extracellular exosome
0.35	GO:0031012	extracellular matrix
0.34	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.30	GO:0016021	integral component of membrane

0.84

EC:2.3.2.13

GO:0003810

sp|P16455|MGMT_HUMAN
Methylated-DNA--protein-cysteine methyltransferase
Search

MGMT

0.45	Methylated-DNA--protein-cysteine methyltransferase

0.65	GO:0006281	DNA repair
0.63	GO:0032259	methylation
0.57	GO:0035510	DNA dealkylation
0.56	GO:2000781	positive regulation of double-strand break repair
0.54	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.52	GO:0060548	negative regulation of cell death
0.44	GO:0051593	response to folic acid
0.44	GO:0060644	mammary gland epithelial cell differentiation
0.43	GO:0071479	cellular response to ionizing radiation
0.43	GO:0045471	response to ethanol

0.78	GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity
0.39	GO:0005509	calcium ion binding
0.37	GO:0003677	DNA binding
0.36	GO:0009008	DNA-methyltransferase activity
0.33	GO:0003700	DNA binding transcription factor activity
0.33	GO:0008270	zinc ion binding
0.32	GO:0016997	alpha-sialidase activity

0.48	GO:0005654	nucleoplasm
0.36	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.78

EC:2.1.1.63

GO:0003908

sp|P16471|PRLR_HUMAN
Prolactin receptor
Search

PRLR

0.66	Prolactin receptor long form

0.85	GO:0038161	prolactin signaling pathway
0.62	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
0.53	GO:0007595	lactation
0.53	GO:0060736	prostate gland growth
0.53	GO:0060644	mammary gland epithelial cell differentiation
0.53	GO:0061377	mammary gland lobule development
0.51	GO:0007259	JAK-STAT cascade
0.51	GO:0030856	regulation of epithelial cell differentiation
0.47	GO:0030155	regulation of cell adhesion
0.41	GO:0042976	activation of Janus kinase activity

0.85	GO:0004925	prolactin receptor activity
0.59	GO:0017046	peptide hormone binding
0.38	GO:0042803	protein homodimerization activity
0.38	GO:0042978	ornithine decarboxylase activator activity
0.37	GO:0046872	metal ion binding
0.35	GO:0019901	protein kinase binding

0.54	GO:0009986	cell surface
0.38	GO:0031904	endosome lumen
0.36	GO:0005886	plasma membrane
0.35	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

sp|P16473|TSHR_HUMAN
Thyrotropin receptor
Search

TSHR

0.95	Thyrotropin receptor

0.86	GO:0038194	thyroid-stimulating hormone signaling pathway
0.59	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.57	GO:0090103	cochlea morphogenesis
0.57	GO:0071542	dopaminergic neuron differentiation
0.56	GO:0060122	inner ear receptor cell stereocilium organization
0.56	GO:0040018	positive regulation of multicellular organism growth
0.55	GO:0030183	B cell differentiation
0.55	GO:0008344	adult locomotory behavior
0.52	GO:0040012	regulation of locomotion
0.51	GO:0007190	activation of adenylate cyclase activity

0.86	GO:0004996	thyroid-stimulating hormone receptor activity
0.48	GO:0008528	G-protein coupled peptide receptor activity
0.42	GO:0032403	protein complex binding

0.54	GO:0005886	plasma membrane
0.38	GO:0005622	intracellular
0.38	GO:0043235	receptor complex
0.35	GO:0045121	membrane raft
0.35	GO:0009986	cell surface
0.30	GO:0016021	integral component of membrane

sp|P16499|PDE6A_HUMAN
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Search

PDE6A

0.54	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

0.61	GO:0007165	signal transduction
0.60	GO:0007601	visual perception
0.59	GO:0051480	regulation of cytosolic calcium ion concentration
0.56	GO:0046037	GMP metabolic process
0.47	GO:0060041	retina development in camera-type eye
0.45	GO:0009583	detection of light stimulus
0.37	GO:0022400	regulation of rhodopsin mediated signaling pathway
0.37	GO:0045494	photoreceptor cell maintenance
0.36	GO:0071482	cellular response to light stimulus
0.36	GO:0198738	cell-cell signaling by wnt

0.80	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.54	GO:0046872	metal ion binding

0.48	GO:0001750	photoreceptor outer segment
0.39	GO:0060170	ciliary membrane

0.80

EC:3.1.4.17

GO:0004114

sp|P16519|NEC2_HUMAN
Neuroendocrine convertase 2
Search

PCSK2

0.95	Proprotein convertase subtilisin kexin type 2 variant 1

0.59	GO:0034230	enkephalin processing
0.59	GO:0030070	insulin processing
0.55	GO:0016540	protein autoprocessing
0.50	GO:0007399	nervous system development
0.41	GO:0034231	islet amyloid polypeptide processing

0.67	GO:0004252	serine-type endopeptidase activity
0.37	GO:0032403	protein complex binding

0.51	GO:0005615	extracellular space
0.45	GO:0005634	nucleus
0.40	GO:0030133	transport vesicle
0.39	GO:0034774	secretory granule lumen
0.39	GO:0043204	perikaryon
0.38	GO:0030425	dendrite
0.35	GO:0005788	endoplasmic reticulum lumen
0.30	GO:0031224	intrinsic component of membrane

0.67

GO:0004252

sp|P16520|GBB3_HUMAN
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Search

GNB3

0.97	GTP-binding protein beta-3 subunit

0.61	GO:0007165	signal transduction
0.43	GO:0060041	retina development in camera-type eye
0.42	GO:0050909	sensory perception of taste
0.42	GO:0008283	cell proliferation
0.37	GO:0048920	posterior lateral line neuromast primordium migration
0.36	GO:0071417	cellular response to organonitrogen compound
0.35	GO:0032870	cellular response to hormone stimulus
0.35	GO:0010659	cardiac muscle cell apoptotic process
0.35	GO:0033762	response to glucagon
0.35	GO:1901701	cellular response to oxygen-containing compound

0.53	GO:0051020	GTPase binding
0.44	GO:0032403	protein complex binding
0.41	GO:0003924	GTPase activity
0.40	GO:0030507	spectrin binding
0.39	GO:0004871	signal transducer activity
0.35	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity
0.35	GO:0031702	type 1 angiotensin receptor binding
0.34	GO:0005246	calcium channel regulator activity
0.34	GO:0004402	histone acetyltransferase activity

0.54	GO:0043005	neuron projection
0.53	GO:0120038	plasma membrane bounded cell projection part
0.52	GO:0036477	somatodendritic compartment
0.46	GO:0043209	myelin sheath
0.44	GO:1905360	GTPase complex
0.43	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.43	GO:0097731	9+0 non-motile cilium
0.40	GO:0044297	cell body
0.40	GO:0048471	perinuclear region of cytoplasm
0.40	GO:0098797	plasma membrane protein complex

0.35

EC:3.1.4.39

GO:0047391

sp|P16562|CRIS2_HUMAN
Cysteine-rich secretory protein 2
Search

0.95	Cysteine-rich secretory protein 2

0.38	GO:0009405	pathogenesis
0.38	GO:0098609	cell-cell adhesion
0.37	GO:0007283	spermatogenesis
0.35	GO:0043312	neutrophil degranulation
0.35	GO:0009566	fertilization
0.34	GO:0045087	innate immune response

0.39

GO:0090729

toxin activity

0.66	GO:0005576	extracellular region
0.44	GO:0042581	specific granule
0.35	GO:1904724	tertiary granule lumen
0.35	GO:0034774	secretory granule lumen
0.34	GO:0030133	transport vesicle
0.30	GO:0016020	membrane

sp|P16581|LYAM2_HUMAN
E-selectin
Search

0.77	E-selectin

0.72	GO:0007155	cell adhesion
0.64	GO:0050900	leukocyte migration
0.51	GO:0033198	response to ATP
0.46	GO:0007202	activation of phospholipase C activity
0.46	GO:0002092	positive regulation of receptor internalization
0.45	GO:0070555	response to interleukin-1
0.42	GO:0030029	actin filament-based process
0.39	GO:0007165	signal transduction
0.38	GO:0033623	regulation of integrin activation
0.38	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling

0.61	GO:0030246	carbohydrate binding
0.51	GO:0005509	calcium ion binding
0.51	GO:0002020	protease binding
0.49	GO:0050839	cell adhesion molecule binding
0.49	GO:0033691	sialic acid binding
0.46	GO:0043274	phospholipase binding
0.41	GO:0004888	transmembrane signaling receptor activity
0.39	GO:0008201	heparin binding
0.37	GO:0001530	lipopolysaccharide binding
0.36	GO:0048306	calcium-dependent protein binding

0.51	GO:0009897	external side of plasma membrane
0.49	GO:0005887	integral component of plasma membrane
0.45	GO:0005901	caveola
0.44	GO:0005905	clathrin-coated pit
0.44	GO:0030863	cortical cytoskeleton
0.43	GO:0048471	perinuclear region of cytoplasm
0.43	GO:0005615	extracellular space
0.39	GO:0030667	secretory granule membrane
0.38	GO:0031091	platelet alpha granule

sp|P16591|FER_HUMAN
Tyrosine-protein kinase Fer
Search

FER

0.61	Tyrosine-protein kinase

0.81	GO:0042058	regulation of epidermal growth factor receptor signaling pathway
0.80	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.77	GO:0030335	positive regulation of cell migration
0.76	GO:0008283	cell proliferation
0.73	GO:0018108	peptidyl-tyrosine phosphorylation
0.73	GO:0031532	actin cytoskeleton reorganization
0.61	GO:0050904	diapedesis
0.61	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase
0.60	GO:0036005	response to macrophage colony-stimulating factor
0.60	GO:0033006	regulation of mast cell activation involved in immune response

0.83	GO:0005154	epidermal growth factor receptor binding
0.77	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.57	GO:0008157	protein phosphatase 1 binding
0.53	GO:0030554	adenyl nucleotide binding
0.52	GO:0032555	purine ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0008289	lipid binding

0.63	GO:0005856	cytoskeleton
0.56	GO:0030027	lamellipodium
0.55	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.52	GO:0000790	nuclear chromatin
0.52	GO:0030054	cell junction
0.49	GO:0005829	cytosol

0.77

GO:0004715

sp|P16615|AT2A2_HUMAN
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Search

ATP2A2

0.53	Calcium-transporting ATPase

0.76	GO:0070588	calcium ion transmembrane transport
0.68	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.57	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration
0.57	GO:1903233	regulation of calcium ion-dependent exocytosis of neurotransmitter
0.56	GO:0033292	T-tubule organization
0.56	GO:0014883	transition between fast and slow fiber
0.56	GO:0070296	sarcoplasmic reticulum calcium ion transport
0.55	GO:0008016	regulation of heart contraction
0.55	GO:0003299	muscle hypertrophy in response to stress
0.55	GO:0014887	cardiac muscle adaptation

0.80	GO:0005388	calcium-transporting ATPase activity
0.54	GO:0044548	S100 protein binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0019899	enzyme binding
0.47	GO:0005509	calcium ion binding
0.39	GO:0031775	lutropin-choriogonadotropic hormone receptor binding
0.38	GO:0008022	protein C-terminus binding

0.56	GO:0097470	ribbon synapse
0.54	GO:0016529	sarcoplasmic reticulum
0.48	GO:0005789	endoplasmic reticulum membrane
0.47	GO:0005654	nucleoplasm
0.39	GO:0090534	calcium ion-transporting ATPase complex
0.39	GO:0098588	bounding membrane of organelle
0.38	GO:0014704	intercalated disc
0.37	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.37	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0012506	vesicle membrane

0.80

EC:3.6.3.8

GO:0005388

sp|P16619|CL3L1_HUMAN
C-C motif chemokine 3-like 1
Search

0.74	C-C motif chemokine

0.82	GO:0060326	cell chemotaxis
0.74	GO:0006955	immune response
0.73	GO:0010469	regulation of receptor activity
0.59	GO:0097529	myeloid leukocyte migration
0.58	GO:0071674	mononuclear cell migration
0.57	GO:0072676	lymphocyte migration
0.56	GO:0043615	astrocyte cell migration
0.56	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.55	GO:0006954	inflammatory response
0.55	GO:2000503	positive regulation of natural killer cell chemotaxis

0.84	GO:0008009	chemokine activity
0.56	GO:0048020	CCR chemokine receptor binding
0.53	GO:0004698	calcium-dependent protein kinase C activity
0.52	GO:0016004	phospholipase activator activity
0.51	GO:0042056	chemoattractant activity
0.41	GO:0042802	identical protein binding
0.35	GO:0008201	heparin binding
0.34	GO:0045236	CXCR chemokine receptor binding
0.33	GO:0003735	structural constituent of ribosome

0.71	GO:0005615	extracellular space
0.44	GO:0005829	cytosol
0.34	GO:0015934	large ribosomal subunit
0.32	GO:0043234	protein complex

0.53

GO:0004698

sp|P16662|UD2B7_HUMAN
UDP-glucuronosyltransferase 2B7
Search

0.54	UDP-glucuronosyltransferase

0.51	GO:0052695	cellular glucuronidation
0.41	GO:0008202	steroid metabolic process
0.38	GO:0034754	cellular hormone metabolic process
0.37	GO:0006805	xenobiotic metabolic process
0.36	GO:0007608	sensory perception of smell
0.34	GO:0016042	lipid catabolic process
0.34	GO:0072329	monocarboxylic acid catabolic process
0.34	GO:1901615	organic hydroxy compound metabolic process
0.33	GO:0009593	detection of chemical stimulus
0.33	GO:0009636	response to toxic substance

0.80	GO:0015020	glucuronosyltransferase activity
0.40	GO:0001972	retinoic acid binding

0.43	GO:0005789	endoplasmic reticulum membrane
0.40	GO:0031090	organelle membrane
0.35	GO:0070062	extracellular exosome
0.34	GO:0005635	nuclear envelope
0.34	GO:0098805	whole membrane
0.33	GO:0019867	outer membrane
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.80

GO:0015020

sp|P16671|CD36_HUMAN
Platelet glycoprotein 4
Search

CD36

0.92	Platelet glycoprotein IV variant

0.74	GO:0006955	immune response
0.71	GO:0007166	cell surface receptor signaling pathway
0.55	GO:0071726	cellular response to diacyl bacterial lipopeptide
0.55	GO:0070543	response to linoleic acid
0.54	GO:0034197	triglyceride transport
0.54	GO:0044539	long-chain fatty acid import
0.54	GO:0055094	response to lipoprotein particle
0.54	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly
0.54	GO:0071402	cellular response to lipoprotein particle stimulus
0.54	GO:0030299	intestinal cholesterol absorption

0.52	GO:0005041	low-density lipoprotein receptor activity
0.51	GO:0070892	lipoteichoic acid receptor activity
0.51	GO:0030169	low-density lipoprotein particle binding
0.51	GO:0035325	Toll-like receptor binding
0.50	GO:0008035	high-density lipoprotein particle binding
0.45	GO:0008289	lipid binding
0.43	GO:0070053	thrombospondin receptor activity
0.42	GO:0050431	transforming growth factor beta binding
0.39	GO:0001540	amyloid-beta binding
0.38	GO:0005044	scavenger receptor activity

0.51	GO:0031526	brush border membrane
0.50	GO:0098857	membrane microdomain
0.49	GO:0045177	apical part of cell
0.49	GO:0005794	Golgi apparatus
0.47	GO:0043235	receptor complex
0.47	GO:0009897	external side of plasma membrane
0.39	GO:0031092	platelet alpha granule membrane
0.39	GO:0035579	specific granule membrane
0.39	GO:0005615	extracellular space
0.38	GO:0030666	endocytic vesicle membrane

sp|P16860|ANFB_HUMAN
Natriuretic peptides B
Search

NPPB

0.97	Natriuretic peptides B

0.78	GO:0050880	regulation of blood vessel size
0.76	GO:0007168	receptor guanylyl cyclase signaling pathway
0.76	GO:0010469	regulation of receptor activity
0.70	GO:0006182	cGMP biosynthetic process
0.58	GO:0006457	protein folding
0.46	GO:0035815	positive regulation of renal sodium excretion
0.45	GO:0035810	positive regulation of urine volume
0.45	GO:0043114	regulation of vascular permeability
0.45	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
0.44	GO:0007589	body fluid secretion

0.79	GO:0005179	hormone activity
0.68	GO:0051427	hormone receptor binding

0.66	GO:0005576	extracellular region
0.51	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

sp|P16870|CBPE_HUMAN
Carboxypeptidase E
Search

CPE

0.96	Carboxypeptidase E

0.62	GO:0030070	insulin processing
0.59	GO:0003214	cardiac left ventricle morphogenesis
0.53	GO:0016055	Wnt signaling pathway
0.51	GO:0072657	protein localization to membrane
0.37	GO:2000173	negative regulation of branching morphogenesis of a nerve
0.36	GO:0034230	enkephalin processing
0.35	GO:0007218	neuropeptide signaling pathway
0.35	GO:0043171	peptide catabolic process
0.33	GO:0036211	protein modification process
0.33	GO:0044267	cellular protein metabolic process

0.75	GO:0004181	metallocarboxypeptidase activity
0.61	GO:0008270	zinc ion binding
0.58	GO:0042043	neurexin family protein binding
0.54	GO:0050839	cell adhesion molecule binding
0.45	GO:0004185	serine-type carboxypeptidase activity
0.35	GO:0050897	cobalt ion binding
0.35	GO:0019904	protein domain specific binding

0.52	GO:0005615	extracellular space
0.51	GO:0005794	Golgi apparatus
0.47	GO:0043025	neuronal cell body
0.47	GO:0030141	secretory granule
0.46	GO:0097060	synaptic membrane
0.42	GO:0030658	transport vesicle membrane
0.37	GO:1903561	extracellular vesicle
0.35	GO:0030425	dendrite
0.35	GO:0045121	membrane raft
0.33	GO:0005634	nucleus

0.75

EC:3.4.17

GO:0004181

sp|P16871|IL7RA_HUMAN
Interleukin-7 receptor subunit alpha
Search

IL7R

0.95	Interleukin-7 receptor subunit alpha

0.79	GO:0019221	cytokine-mediated signaling pathway
0.66	GO:0001915	negative regulation of T cell mediated cytotoxicity
0.64	GO:0033089	positive regulation of T cell differentiation in thymus
0.63	GO:0048535	lymph node development
0.62	GO:1904894	positive regulation of STAT cascade
0.62	GO:0042100	B cell proliferation
0.61	GO:0002377	immunoglobulin production
0.60	GO:0030217	T cell differentiation
0.59	GO:0008361	regulation of cell size
0.58	GO:0016049	cell growth

0.81	GO:0004896	cytokine receptor activity
0.38	GO:0003823	antigen binding
0.35	GO:0005515	protein binding

0.59	GO:0009897	external side of plasma membrane
0.38	GO:0031514	motile cilium
0.37	GO:0030665	clathrin-coated vesicle membrane
0.35	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

sp|P16885|PLCG2_HUMAN
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Search

PLCG2

0.53	Phosphoinositide phospholipase C

0.77	GO:0009395	phospholipid catabolic process
0.62	GO:0002316	follicular B cell differentiation
0.62	GO:0035556	intracellular signal transduction
0.61	GO:0032959	inositol trisphosphate biosynthetic process
0.59	GO:0032237	activation of store-operated calcium channel activity
0.59	GO:0002092	positive regulation of receptor internalization
0.58	GO:0050852	T cell receptor signaling pathway
0.58	GO:0032481	positive regulation of type I interferon production
0.57	GO:0051209	release of sequestered calcium ion into cytosol
0.57	GO:0050853	B cell receptor signaling pathway

0.81	GO:0004435	phosphatidylinositol phospholipase C activity
0.63	GO:0004871	signal transducer activity
0.57	GO:0001784	phosphotyrosine residue binding
0.41	GO:0005509	calcium ion binding
0.34	GO:0005168	neurotrophin TRKA receptor binding
0.34	GO:0035254	glutamate receptor binding
0.34	GO:0030971	receptor tyrosine kinase binding

0.49	GO:0005829	cytosol
0.43	GO:0005886	plasma membrane
0.34	GO:0001726	ruffle
0.34	GO:0030027	lamellipodium
0.34	GO:0008180	COP9 signalosome
0.33	GO:0005911	cell-cell junction
0.30	GO:0016021	integral component of membrane

0.81	EC:3.1.4.11	GO:0004435
0.81	KEGG:R03435	GO:0004435

sp|P16930|FAAA_HUMAN
Fumarylacetoacetase
Search

FAH

0.50	Fumarylacetoacetate hydrolase

0.69	GO:0009072	aromatic amino acid family metabolic process
0.50	GO:0006527	arginine catabolic process
0.39	GO:1902222	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process
0.37	GO:0042737	drug catabolic process
0.36	GO:1901361	organic cyclic compound catabolic process
0.36	GO:0019439	aromatic compound catabolic process
0.34	GO:0006396	RNA processing
0.34	GO:0001510	RNA methylation
0.33	GO:0090501	RNA phosphodiester bond hydrolysis
0.33	GO:0006399	tRNA metabolic process

0.83	GO:0004334	fumarylacetoacetase activity
0.34	GO:0046872	metal ion binding
0.34	GO:0140098	catalytic activity, acting on RNA
0.33	GO:0008168	methyltransferase activity
0.33	GO:0005515	protein binding
0.33	GO:0003723	RNA binding
0.33	GO:0004518	nuclease activity
0.33	GO:0016829	lyase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.36	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol

0.83	EC:3.7.1.2	GO:0004334
0.83	KEGG:R01364	GO:0004334

sp|P16949|STMN1_HUMAN
Stathmin
Search

STMN1

0.86

Stathmin

0.84	GO:0031110	regulation of microtubule polymerization or depolymerization
0.55	GO:0007019	microtubule depolymerization
0.55	GO:0070495	negative regulation of thrombin-activated receptor signaling pathway
0.54	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity
0.53	GO:0048012	hepatocyte growth factor receptor signaling pathway
0.53	GO:0051497	negative regulation of stress fiber assembly
0.53	GO:0061436	establishment of skin barrier
0.53	GO:0035024	negative regulation of Rho protein signal transduction
0.52	GO:0032272	negative regulation of protein polymerization
0.51	GO:0031175	neuron projection development

0.49	GO:0015631	tubulin binding
0.39	GO:0048306	calcium-dependent protein binding
0.37	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity
0.33	GO:0004871	signal transducer activity

0.47	GO:0043005	neuron projection
0.45	GO:0005829	cytosol
0.40	GO:0005874	microtubule
0.39	GO:0030427	site of polarized growth
0.39	GO:0120038	plasma membrane bounded cell projection part
0.38	GO:0030027	lamellipodium
0.38	GO:0043025	neuronal cell body
0.38	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.37

EC:3.1.1.47

GO:0003847

sp|P16989|YBOX3_HUMAN
Y-box-binding protein 3
Search

YBX3

0.94	TSH receptor suppressor element-binding protein-1

0.63	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
0.62	GO:0060546	negative regulation of necroptotic process
0.60	GO:0048642	negative regulation of skeletal muscle tissue development
0.59	GO:0071474	cellular hyperosmotic response
0.58	GO:0046622	positive regulation of organ growth
0.58	GO:0071356	cellular response to tumor necrosis factor
0.57	GO:0008584	male gonad development
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression

0.57	GO:0003730	mRNA 3'-UTR binding
0.56	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.55	GO:0003677	DNA binding
0.53	GO:0001067	regulatory region nucleic acid binding
0.41	GO:0008190	eukaryotic initiation factor 4E binding
0.39	GO:0051020	GTPase binding
0.36	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.36	GO:0003714	transcription corepressor activity
0.35	GO:0003682	chromatin binding
0.35	GO:0004725	protein tyrosine phosphatase activity

0.56	GO:0005844	polysome
0.50	GO:0005829	cytosol
0.47	GO:0005634	nucleus
0.40	GO:0005911	cell-cell junction
0.39	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0070937	CRD-mediated mRNA stability complex
0.36	GO:0010494	cytoplasmic stress granule
0.34	GO:1990124	messenger ribonucleoprotein complex
0.34	GO:0044446	intracellular organelle part
0.34	GO:0043025	neuronal cell body

0.35

GO:0004725

sp|P17010|ZFX_HUMAN
Zinc finger X-chromosomal protein
Search

ZFX

0.67	Zinc finger protein, X-linked

0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.50	GO:0060746	parental behavior
0.48	GO:0001541	ovarian follicle development
0.48	GO:0035264	multicellular organism growth
0.48	GO:0048599	oocyte development
0.47	GO:0009566	fertilization
0.46	GO:0007283	spermatogenesis
0.46	GO:0009791	post-embryonic development

0.53	GO:0003677	DNA binding
0.52	GO:0046872	metal ion binding
0.35	GO:0003713	transcription coactivator activity
0.33	GO:0005515	protein binding

0.59	GO:0005634	nucleus
0.42	GO:0031974	membrane-enclosed lumen
0.40	GO:0043232	intracellular non-membrane-bounded organelle
0.39	GO:0044446	intracellular organelle part

sp|P17014|ZNF12_HUMAN
Zinc finger protein 12
Search

0.86	RB associated KRAB zinc finger

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.37	GO:0006351	transcription, DNA-templated
0.37	GO:1902679	negative regulation of RNA biosynthetic process

0.53	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding

0.54

GO:0005654

nucleoplasm

sp|P17017|ZNF14_HUMAN
Zinc finger protein 14
Search

0.59	Zinc finger protein 57

0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:1903506	regulation of nucleic acid-templated transcription
0.54	GO:0010468	regulation of gene expression
0.40	GO:0097659	nucleic acid-templated transcription
0.39	GO:0010467	gene expression
0.38	GO:0034645	cellular macromolecule biosynthetic process

0.53	GO:0000976	transcription regulatory region sequence-specific DNA binding
0.51	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.44	GO:0005622	intracellular
0.39	GO:0043227	membrane-bounded organelle

sp|P17019|ZN708_HUMAN
Zinc finger protein 708
Search

0.68	Zinc finger protein 91

0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.47	GO:0070895	negative regulation of transposon integration
0.47	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway
0.46	GO:1902679	negative regulation of RNA biosynthetic process
0.46	GO:0043508	negative regulation of JUN kinase activity
0.46	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
0.45	GO:0045671	negative regulation of osteoclast differentiation
0.45	GO:2000678	negative regulation of transcription regulatory region DNA binding

0.52	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.43	GO:0031625	ubiquitin protein ligase binding
0.41	GO:0003700	DNA binding transcription factor activity
0.33	GO:0003682	chromatin binding

0.46	GO:0005634	nucleus
0.43	GO:0048471	perinuclear region of cytoplasm

sp|P17020|ZNF16_HUMAN
Zinc finger protein 16
Search

ZNF23

0.79	LOW QUALITY PROTEIN: zinc finger protein 16

0.53	GO:1903506	regulation of nucleic acid-templated transcription
0.53	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.52	GO:0010468	regulation of gene expression
0.44	GO:0071294	cellular response to zinc ion
0.43	GO:0006366	transcription by RNA polymerase II
0.42	GO:0031325	positive regulation of cellular metabolic process
0.42	GO:0010557	positive regulation of macromolecule biosynthetic process
0.41	GO:0051173	positive regulation of nitrogen compound metabolic process
0.41	GO:0048523	negative regulation of cellular process
0.40	GO:0010558	negative regulation of macromolecule biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.50	GO:0046872	metal ion binding
0.44	GO:0003700	DNA binding transcription factor activity
0.35	GO:0005515	protein binding
0.34	GO:0003735	structural constituent of ribosome

0.43	GO:0005634	nucleus
0.41	GO:0043233	organelle lumen
0.39	GO:0043232	intracellular non-membrane-bounded organelle
0.39	GO:0044446	intracellular organelle part
0.34	GO:0005829	cytosol
0.33	GO:0030529	intracellular ribonucleoprotein complex

sp|P17021|ZNF17_HUMAN
Zinc finger protein 17
Search

ZNF12

0.84	Zinc finger protein 12

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.46	GO:1902679	negative regulation of RNA biosynthetic process
0.36	GO:0006351	transcription, DNA-templated

0.52	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.40	GO:0003700	DNA binding transcription factor activity
0.34	GO:0005515	protein binding

0.45	GO:0005813	centrosome
0.43	GO:0005654	nucleoplasm
0.34	GO:0019013	viral nucleocapsid
0.33	GO:0030529	intracellular ribonucleoprotein complex

sp|P17022|ZNF18_HUMAN
Zinc finger protein 18
Search

ZNF18

0.97	Zinc finger protein 18

0.54	GO:2001141	regulation of RNA biosynthetic process
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:0010468	regulation of gene expression
0.49	GO:0006351	transcription, DNA-templated
0.36	GO:0051253	negative regulation of RNA metabolic process
0.36	GO:0010558	negative regulation of macromolecule biosynthetic process
0.36	GO:0031327	negative regulation of cellular biosynthetic process
0.34	GO:0060026	convergent extension
0.33	GO:0071157	negative regulation of cell cycle arrest
0.33	GO:0030335	positive regulation of cell migration

0.55	GO:0003700	DNA binding transcription factor activity
0.50	GO:0003676	nucleic acid binding
0.49	GO:0046872	metal ion binding
0.35	GO:0005515	protein binding

0.55	GO:0005634	nucleus
0.34	GO:0015629	actin cytoskeleton
0.34	GO:0005829	cytosol
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part
0.32	GO:0005886	plasma membrane

sp|P17023|ZNF19_HUMAN
Zinc finger protein 19
Search

0.66	Zinc finger protein 19

0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.42	GO:1902679	negative regulation of RNA biosynthetic process
0.39	GO:0006351	transcription, DNA-templated
0.38	GO:1902680	positive regulation of RNA biosynthetic process
0.35	GO:0043043	peptide biosynthetic process
0.34	GO:0044267	cellular protein metabolic process

0.51	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.45	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.35	GO:0003735	structural constituent of ribosome
0.34	GO:0005515	protein binding

0.44	GO:0017053	transcriptional repressor complex
0.44	GO:0005622	intracellular
0.41	GO:0043227	membrane-bounded organelle
0.41	GO:0031974	membrane-enclosed lumen
0.39	GO:0044422	organelle part
0.35	GO:1990904	ribonucleoprotein complex
0.34	GO:0043228	non-membrane-bounded organelle

sp|P17024|ZNF20_HUMAN
Zinc finger protein 20
Search

0.74	Zinc finger protein 69

0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.40	GO:0006351	transcription, DNA-templated
0.37	GO:0051253	negative regulation of RNA metabolic process
0.37	GO:0010558	negative regulation of macromolecule biosynthetic process
0.37	GO:0031327	negative regulation of cellular biosynthetic process

0.53	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.40	GO:0005515	protein binding
0.38	GO:0003714	transcription corepressor activity

0.45	GO:0005622	intracellular
0.40	GO:0043227	membrane-bounded organelle

sp|P17025|ZN182_HUMAN
Zinc finger protein 182
Search

0.65	Zinc finger protein 37 homolog

0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:1903506	regulation of nucleic acid-templated transcription
0.54	GO:0010468	regulation of gene expression
0.34	GO:0097659	nucleic acid-templated transcription
0.34	GO:0010467	gene expression
0.34	GO:0034645	cellular macromolecule biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.51	GO:0046872	metal ion binding
0.42	GO:0003700	DNA binding transcription factor activity

0.43	GO:0005622	intracellular
0.38	GO:0043227	membrane-bounded organelle

sp|P17026|ZNF22_HUMAN
Zinc finger protein 22
Search

0.10	Zinc finger protein 22

0.53	GO:1903506	regulation of nucleic acid-templated transcription
0.53	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:0010468	regulation of gene expression
0.37	GO:0006351	transcription, DNA-templated
0.30	GO:0048731	system development
0.30	GO:0009653	anatomical structure morphogenesis

0.51	GO:0003676	nucleic acid binding
0.50	GO:0046872	metal ion binding
0.43	GO:0003700	DNA binding transcription factor activity

0.43	GO:0005622	intracellular
0.41	GO:0070062	extracellular exosome
0.30	GO:0031974	membrane-enclosed lumen
0.30	GO:0044422	organelle part

sp|P17027|ZNF23_HUMAN
Zinc finger protein 23
Search

0.72	Zinc finger protein 23

0.54	GO:1903506	regulation of nucleic acid-templated transcription
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:0010468	regulation of gene expression
0.42	GO:1902679	negative regulation of RNA biosynthetic process
0.37	GO:0042981	regulation of apoptotic process
0.36	GO:0010467	gene expression
0.36	GO:0009059	macromolecule biosynthetic process
0.35	GO:0044271	cellular nitrogen compound biosynthetic process
0.35	GO:0016070	RNA metabolic process
0.35	GO:0006518	peptide metabolic process

0.51	GO:0003676	nucleic acid binding
0.51	GO:0046872	metal ion binding
0.43	GO:0003700	DNA binding transcription factor activity
0.36	GO:0005515	protein binding
0.35	GO:0003735	structural constituent of ribosome

0.43	GO:0005622	intracellular
0.42	GO:0031974	membrane-enclosed lumen
0.40	GO:0044422	organelle part
0.39	GO:0043227	membrane-bounded organelle
0.39	GO:0043228	non-membrane-bounded organelle
0.38	GO:0043230	extracellular organelle
0.36	GO:0005615	extracellular space
0.35	GO:1990904	ribonucleoprotein complex
0.30	GO:0016020	membrane

sp|P17028|ZNF24_HUMAN
Zinc finger protein 24
Search

ZNF24

0.92	Zinc finger with KRAB and SCAN domains 4

0.65	GO:0042552	myelination
0.58	GO:0006366	transcription by RNA polymerase II
0.58	GO:0045944	positive regulation of transcription by RNA polymerase II
0.56	GO:0045892	negative regulation of transcription, DNA-templated
0.33	GO:0015074	DNA integration
0.31	GO:0006468	protein phosphorylation

0.62	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.53	GO:0043565	sequence-specific DNA binding
0.51	GO:0046872	metal ion binding
0.35	GO:0005515	protein binding
0.33	GO:0044212	transcription regulatory region DNA binding
0.33	GO:0003690	double-stranded DNA binding
0.32	GO:0004672	protein kinase activity
0.31	GO:0030554	adenyl nucleotide binding
0.31	GO:0032555	purine ribonucleotide binding
0.31	GO:0008144	drug binding

0.58	GO:0005634	nucleus
0.33	GO:0005829	cytosol

sp|P17029|ZKSC1_HUMAN
Zinc finger protein with KRAB and SCAN domains 1
Search

0.64	zinc finger protein with KRAB and SCAN domains 5

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:0006351	transcription, DNA-templated
0.35	GO:1902679	negative regulation of RNA biosynthetic process
0.35	GO:0007219	Notch signaling pathway
0.34	GO:0045321	leukocyte activation
0.34	GO:1902680	positive regulation of RNA biosynthetic process
0.34	GO:0030154	cell differentiation
0.34	GO:0007275	multicellular organism development

0.59	GO:0003700	DNA binding transcription factor activity
0.51	GO:0046872	metal ion binding
0.50	GO:0003676	nucleic acid binding
0.41	GO:0042802	identical protein binding
0.34	GO:0003682	chromatin binding
0.34	GO:0046982	protein heterodimerization activity

0.58	GO:0005634	nucleus
0.40	GO:0005829	cytosol
0.39	GO:0015630	microtubule cytoskeleton
0.38	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part
0.35	GO:0005886	plasma membrane

sp|P17030|ZNF25_HUMAN
Zinc finger protein 25
Search

ZNF25

0.76	Zinc finger protein 25

0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.37	GO:1902679	negative regulation of RNA biosynthetic process
0.36	GO:0006351	transcription, DNA-templated
0.35	GO:0043392	negative regulation of DNA binding
0.34	GO:1902680	positive regulation of RNA biosynthetic process

0.52	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.41	GO:0003700	DNA binding transcription factor activity
0.33	GO:0005515	protein binding

0.44	GO:0005622	intracellular
0.36	GO:0043227	membrane-bounded organelle
0.30	GO:0016020	membrane

sp|P17031|ZNF26_HUMAN
Zinc finger protein 26
Search

ZNF26

0.74	Zinc finger protein 26

0.54	GO:1903506	regulation of nucleic acid-templated transcription
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:0010468	regulation of gene expression
0.40	GO:0071157	negative regulation of cell cycle arrest
0.39	GO:0030335	positive regulation of cell migration
0.39	GO:0006366	transcription by RNA polymerase II
0.39	GO:0008285	negative regulation of cell proliferation
0.39	GO:0008284	positive regulation of cell proliferation
0.39	GO:0043065	positive regulation of apoptotic process
0.39	GO:0045597	positive regulation of cell differentiation

0.51	GO:0046872	metal ion binding
0.50	GO:0003676	nucleic acid binding
0.44	GO:0003700	DNA binding transcription factor activity
0.34	GO:0005515	protein binding

0.43	GO:0005622	intracellular
0.38	GO:0043227	membrane-bounded organelle
0.38	GO:0043228	non-membrane-bounded organelle
0.37	GO:0031974	membrane-enclosed lumen
0.35	GO:0044422	organelle part

sp|P17032|ZN37A_HUMAN
Zinc finger protein 37A
Search

0.76	Zinc finger domain-containing protein (Fragment)

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.47	GO:1902680	positive regulation of RNA biosynthetic process
0.46	GO:0006366	transcription by RNA polymerase II
0.39	GO:0043392	negative regulation of DNA binding
0.38	GO:1902679	negative regulation of RNA biosynthetic process
0.36	GO:0071294	cellular response to zinc ion
0.34	GO:0043043	peptide biosynthetic process
0.34	GO:0042254	ribosome biogenesis

0.53	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.48	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.39	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.36	GO:0005515	protein binding
0.35	GO:0003735	structural constituent of ribosome

0.46	GO:0005730	nucleolus
0.35	GO:0005654	nucleoplasm
0.35	GO:0044444	cytoplasmic part
0.35	GO:0030529	intracellular ribonucleoprotein complex

sp|P17035|ZNF28_HUMAN
Zinc finger protein 28
Search

0.67	Zinc finger protein 28

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.40	GO:0006351	transcription, DNA-templated
0.39	GO:0030097	hemopoiesis

0.51	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.41	GO:0003700	DNA binding transcription factor activity
0.35	GO:0005515	protein binding

0.44	GO:0005622	intracellular
0.40	GO:0043227	membrane-bounded organelle
0.39	GO:0031974	membrane-enclosed lumen
0.37	GO:0043228	non-membrane-bounded organelle
0.36	GO:0044422	organelle part

sp|P17036|ZNF3_HUMAN
Zinc finger protein 3
Search

ZKSCAN1

0.94	Zinc finger protein with KRAB and SCAN domains 1

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.55	GO:0097659	nucleic acid-templated transcription
0.51	GO:0010467	gene expression
0.50	GO:0034645	cellular macromolecule biosynthetic process

0.59	GO:0003700	DNA binding transcription factor activity
0.53	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.35	GO:0005515	protein binding

0.59

GO:0005634

nucleus

sp|P17038|ZNF43_HUMAN
Zinc finger protein 43
Search

0.62	Zinc finger protein 91

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.48	GO:0070895	negative regulation of transposon integration
0.44	GO:1902679	negative regulation of RNA biosynthetic process
0.41	GO:0006351	transcription, DNA-templated

0.54	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.43	GO:0003700	DNA binding transcription factor activity
0.39	GO:0003714	transcription corepressor activity
0.36	GO:0005515	protein binding

0.46

GO:0005634

nucleus

sp|P17039|ZNF30_HUMAN
Zinc finger protein 30
Search

0.60	Zinc finger domain-containing protein (Fragment)

0.53	GO:1903506	regulation of nucleic acid-templated transcription
0.53	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.52	GO:0010468	regulation of gene expression
0.38	GO:0006351	transcription, DNA-templated
0.35	GO:0034249	negative regulation of cellular amide metabolic process
0.34	GO:0032269	negative regulation of cellular protein metabolic process
0.34	GO:1902679	negative regulation of RNA biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.50	GO:0046872	metal ion binding
0.43	GO:0003700	DNA binding transcription factor activity
0.36	GO:0030371	translation repressor activity
0.35	GO:0005515	protein binding

0.45	GO:0016604	nuclear body
0.35	GO:0005829	cytosol

sp|P17040|ZSC20_HUMAN
Zinc finger and SCAN domain-containing protein 20
Search

ZSCAN20

0.77	Zinc finger and SCAN domain-containing protein 20

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.53	GO:0097659	nucleic acid-templated transcription
0.50	GO:0010467	gene expression
0.49	GO:0034645	cellular macromolecule biosynthetic process

0.60	GO:0003700	DNA binding transcription factor activity
0.52	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.30	GO:0005515	protein binding

0.59

GO:0005634

nucleus

sp|P17041|ZNF32_HUMAN
Zinc finger protein 32
Search

0.63	Zinc finger protein 32

0.47	GO:1903506	regulation of nucleic acid-templated transcription
0.47	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.47	GO:0010468	regulation of gene expression
0.35	GO:0006351	transcription, DNA-templated

0.50	GO:0003676	nucleic acid binding
0.44	GO:0046872	metal ion binding
0.41	GO:0003700	DNA binding transcription factor activity
0.34	GO:0005515	protein binding

0.40

GO:0016607

nuclear speck

sp|P17050|NAGAB_HUMAN
Alpha-N-acetylgalactosaminidase
Search

NAGA

0.77	Alpha-N-acetylgalactosaminidase

0.60	GO:0005975	carbohydrate metabolic process
0.59	GO:0019377	glycolipid catabolic process
0.50	GO:0016139	glycoside catabolic process
0.49	GO:0006677	glycosylceramide metabolic process
0.48	GO:0046514	ceramide catabolic process

0.66	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.52	GO:0042803	protein homodimerization activity

0.39	GO:0005764	lysosome
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.66

EC:3.2.1

GO:0004553

sp|P17066|HSP76_HUMAN
Heat shock 70 kDa protein 6
Search

0.53	Heat shock protein 6

0.48	GO:0090063	positive regulation of microtubule nucleation
0.46	GO:0042026	protein refolding
0.46	GO:0006108	malate metabolic process
0.46	GO:1901673	regulation of mitotic spindle assembly
0.43	GO:0006099	tricarboxylic acid cycle
0.43	GO:0009408	response to heat
0.41	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress
0.40	GO:0005975	carbohydrate metabolic process
0.40	GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
0.40	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway

0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.46	GO:0030060	L-malate dehydrogenase activity
0.43	GO:0031072	heat shock protein binding
0.41	GO:0019899	enzyme binding
0.41	GO:0051082	unfolded protein binding
0.41	GO:0055131	C3HC4-type RING finger domain binding
0.41	GO:0031249	denatured protein binding

0.45	GO:0005815	microtubule organizing center
0.42	GO:0008180	COP9 signalosome
0.41	GO:0005829	cytosol
0.40	GO:0030529	intracellular ribonucleoprotein complex
0.40	GO:0072562	blood microparticle
0.40	GO:0070062	extracellular exosome
0.40	GO:0016235	aggresome
0.39	GO:0002199	zona pellucida receptor complex
0.39	GO:0016607	nuclear speck
0.39	GO:1904813	ficolin-1-rich granule lumen

0.46	EC:1.1.1.37	GO:0030060
0.34	KEGG:R03665	GO:0004832

sp|P17081|RHOQ_HUMAN
Rho-related GTP-binding protein RhoQ
Search

RHOQ

0.95	Epididymis secretory protein Li 42

0.77	GO:0007264	small GTPase mediated signal transduction
0.54	GO:1903077	negative regulation of protein localization to plasma membrane
0.53	GO:0051491	positive regulation of filopodium assembly
0.53	GO:0046326	positive regulation of glucose import
0.52	GO:0008286	insulin receptor signaling pathway
0.52	GO:0030036	actin cytoskeleton organization
0.51	GO:0030865	cortical cytoskeleton organization
0.50	GO:0022603	regulation of anatomical structure morphogenesis
0.49	GO:0046039	GTP metabolic process
0.48	GO:0045944	positive regulation of transcription by RNA polymerase II

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.56	GO:0032427	GBD domain binding
0.55	GO:0005522	profilin binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0046983	protein dimerization activity
0.32	GO:0003700	DNA binding transcription factor activity

0.51	GO:0005884	actin filament
0.51	GO:0045121	membrane raft
0.41	GO:0005886	plasma membrane
0.37	GO:0070062	extracellular exosome
0.34	GO:0030660	Golgi-associated vesicle membrane
0.33	GO:0005829	cytosol
0.33	GO:0005667	transcription factor complex
0.32	GO:0005634	nucleus

sp|P17096|HMGA1_HUMAN
High mobility group protein HMG-I/HMG-Y
Search

HMGA1

0.97	High mobility group protein HMG-I/HMG-Y

0.60	GO:0090402	oncogene-induced cell senescence
0.59	GO:0035986	senescence-associated heterochromatin focus assembly
0.58	GO:2000774	positive regulation of cellular senescence
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:0042127	regulation of cell proliferation
0.50	GO:1902680	positive regulation of RNA biosynthetic process
0.49	GO:1902679	negative regulation of RNA biosynthetic process
0.48	GO:0009615	response to virus

0.57	GO:0042975	peroxisome proliferator activated receptor binding
0.56	GO:0046965	retinoid X receptor binding
0.55	GO:0003680	AT DNA binding
0.53	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
0.52	GO:0001158	enhancer sequence-specific DNA binding
0.47	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
0.46	GO:0019899	enzyme binding
0.44	GO:0051575	5'-deoxyribose-5-phosphate lyase activity
0.43	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.42	GO:0003682	chromatin binding

0.72	GO:0000785	chromatin
0.61	GO:0005634	nucleus
0.40	GO:0071141	SMAD protein complex
0.40	GO:0005667	transcription factor complex
0.37	GO:0070013	intracellular organelle lumen
0.37	GO:0005925	focal adhesion
0.37	GO:0032993	protein-DNA complex
0.34	GO:0005829	cytosol

0.47

EC:4.2.99.18

GO:0003906

sp|P17097|ZNF7_HUMAN
Zinc finger protein 7
Search

ZNF7

0.92	Zinc finger protein 7

0.54	GO:1903506	regulation of nucleic acid-templated transcription
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:0010468	regulation of gene expression
0.36	GO:0007576	nucleolar fragmentation
0.36	GO:0007275	multicellular organism development
0.36	GO:0006351	transcription, DNA-templated
0.35	GO:0051593	response to folic acid
0.35	GO:1902679	negative regulation of RNA biosynthetic process
0.35	GO:0001666	response to hypoxia
0.34	GO:0007605	sensory perception of sound

0.50	GO:0003676	nucleic acid binding
0.50	GO:0046872	metal ion binding
0.42	GO:0003700	DNA binding transcription factor activity
0.34	GO:0003682	chromatin binding
0.34	GO:0003735	structural constituent of ribosome
0.32	GO:0005515	protein binding

0.43	GO:0005622	intracellular
0.42	GO:0031974	membrane-enclosed lumen
0.39	GO:0043227	membrane-bounded organelle
0.39	GO:0044422	organelle part
0.38	GO:0043228	non-membrane-bounded organelle
0.33	GO:1990904	ribonucleoprotein complex
0.30	GO:0016020	membrane

sp|P17098|ZNF8_HUMAN
Zinc finger protein 8
Search

0.85	Zinc finger protein 8

0.54	GO:0030509	BMP signaling pathway
0.53	GO:0000122	negative regulation of transcription by RNA polymerase II
0.37	GO:0006351	transcription, DNA-templated
0.37	GO:0043392	negative regulation of DNA binding
0.36	GO:0045893	positive regulation of transcription, DNA-templated
0.35	GO:0070895	negative regulation of transposon integration
0.33	GO:0007275	multicellular organism development
0.33	GO:0006413	translational initiation
0.33	GO:0007010	cytoskeleton organization
0.33	GO:0022604	regulation of cell morphogenesis

0.51	GO:0046872	metal ion binding
0.50	GO:0003676	nucleic acid binding
0.40	GO:0003700	DNA binding transcription factor activity
0.34	GO:0005515	protein binding

0.48	GO:0005634	nucleus
0.39	GO:0015629	actin cytoskeleton
0.38	GO:0043233	organelle lumen
0.36	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|P17152|TMM11_HUMAN
Transmembrane protein 11, mitochondrial
Search

TMEM11

0.56	Transmembrane protein 11-B, mitochondrial

0.75	GO:0007005	mitochondrion organization
0.33	GO:0043413	macromolecule glycosylation
0.33	GO:0009101	glycoprotein biosynthetic process
0.32	GO:0036211	protein modification process
0.32	GO:0044267	cellular protein metabolic process

0.34	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
0.33	GO:0005515	protein binding
0.32	GO:0046872	metal ion binding

0.81	GO:0031305	integral component of mitochondrial inner membrane
0.33	GO:0005887	integral component of plasma membrane
0.33	GO:0000139	Golgi membrane

0.34

EC:2.4.1.135

GO:0015018

sp|P17174|AATC_HUMAN
Aspartate aminotransferase, cytoplasmic
Search

GOT1

0.49	Aspartate aminotransferase

0.62	GO:0006114	glycerol biosynthetic process
0.62	GO:0006532	aspartate biosynthetic process
0.62	GO:0019550	glutamate catabolic process to aspartate
0.61	GO:0006533	aspartate catabolic process
0.60	GO:0055089	fatty acid homeostasis
0.58	GO:0051384	response to glucocorticoid
0.57	GO:0032869	cellular response to insulin stimulus
0.57	GO:0006103	2-oxoglutarate metabolic process
0.56	GO:0007219	Notch signaling pathway
0.55	GO:0006107	oxaloacetate metabolic process

0.82	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity
0.78	GO:0070546	L-phenylalanine aminotransferase activity
0.67	GO:0030170	pyridoxal phosphate binding
0.54	GO:0004609	phosphatidylserine decarboxylase activity
0.48	GO:0047801	L-cysteine:2-oxoglutarate aminotransferase activity
0.37	GO:0031406	carboxylic acid binding

0.51	GO:0005829	cytosol
0.50	GO:0005654	nucleoplasm
0.40	GO:0005739	mitochondrion
0.39	GO:0043679	axon terminus
0.38	GO:0005764	lysosome
0.36	GO:0070062	extracellular exosome

0.82	EC:2.6.1.1	GO:0004069
0.82	KEGG:R00355	GO:0004069

sp|P17181|INAR1_HUMAN
Interferon alpha/beta receptor 1
Search

IFNAR1

0.97	Interferon alpha and beta receptor subunit 1

0.70	GO:0019221	cytokine-mediated signaling pathway
0.66	GO:0071357	cellular response to type I interferon
0.49	GO:0035457	cellular response to interferon-alpha
0.47	GO:0032496	response to lipopolysaccharide
0.42	GO:0045351	type I interferon biosynthetic process
0.41	GO:0009615	response to virus
0.41	GO:0050718	positive regulation of interleukin-1 beta secretion
0.41	GO:0032728	positive regulation of interferon-beta production
0.41	GO:0032729	positive regulation of interferon-gamma production
0.40	GO:0042110	T cell activation

0.80	GO:0004904	interferon receptor activity
0.54	GO:0004920	interleukin-10 receptor activity
0.51	GO:0019962	type I interferon binding

0.52	GO:0005887	integral component of plasma membrane
0.44	GO:0005770	late endosome
0.43	GO:0005764	lysosome

sp|P17213|BPI_HUMAN
Bactericidal permeability-increasing protein
Search

BPI

0.89	Bactericidal/permeability-increasing protein (Fragment)

0.81	GO:0050829	defense response to Gram-negative bacterium
0.72	GO:0006955	immune response
0.66	GO:0032717	negative regulation of interleukin-8 production
0.66	GO:0032720	negative regulation of tumor necrosis factor production
0.66	GO:0043030	regulation of macrophage activation
0.65	GO:0032715	negative regulation of interleukin-6 production
0.63	GO:0002695	negative regulation of leukocyte activation
0.53	GO:0006953	acute-phase response
0.42	GO:0032760	positive regulation of tumor necrosis factor production
0.42	GO:0042116	macrophage activation

0.80	GO:0001530	lipopolysaccharide binding
0.41	GO:0070891	lipoteichoic acid binding
0.41	GO:0071723	lipopeptide binding
0.37	GO:0005102	receptor binding
0.36	GO:0005200	structural constituent of cytoskeleton
0.35	GO:0003924	GTPase activity
0.35	GO:0051539	4 iron, 4 sulfur cluster binding
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0019001	guanyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding

0.69	GO:0005615	extracellular space
0.39	GO:0005737	cytoplasm
0.38	GO:0009986	cell surface
0.36	GO:0005874	microtubule
0.30	GO:0016020	membrane

sp|P17252|KPCA_HUMAN
Protein kinase C alpha type
Search

PRKCA

0.76	Protein kinase C alpha type

0.64	GO:0035408	histone H3-T6 phosphorylation
0.62	GO:0035556	intracellular signal transduction
0.59	GO:0045766	positive regulation of angiogenesis
0.59	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
0.59	GO:0034351	negative regulation of glial cell apoptotic process
0.58	GO:0090330	regulation of platelet aggregation
0.57	GO:0002159	desmosome assembly
0.56	GO:0001938	positive regulation of endothelial cell proliferation
0.56	GO:0010595	positive regulation of endothelial cell migration
0.55	GO:0043535	regulation of blood vessel endothelial cell migration

0.82	GO:0004697	protein kinase C activity
0.64	GO:0035403	histone kinase activity (H3-T6 specific)
0.62	GO:0008270	zinc ion binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.52	GO:0019899	enzyme binding
0.47	GO:0050681	androgen receptor binding
0.46	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity

0.51	GO:0005829	cytosol
0.49	GO:0005886	plasma membrane
0.48	GO:0005783	endoplasmic reticulum
0.41	GO:0005654	nucleoplasm
0.39	GO:0048471	perinuclear region of cytoplasm
0.38	GO:0070062	extracellular exosome
0.38	GO:0001750	photoreceptor outer segment
0.36	GO:0043025	neuronal cell body
0.36	GO:0030425	dendrite
0.36	GO:0045177	apical part of cell

0.82

EC:2.7.11.13

GO:0004697

sp|P17275|JUNB_HUMAN
Transcription factor jun-B
Search

0.93	Transcription factor jun-B

0.70	GO:0051726	regulation of cell cycle
0.67	GO:0006357	regulation of transcription by RNA polymerase II
0.63	GO:0033687	osteoblast proliferation
0.63	GO:0071277	cellular response to calcium ion
0.62	GO:0060136	embryonic process involved in female pregnancy
0.62	GO:0002573	myeloid leukocyte differentiation
0.61	GO:0001944	vasculature development
0.61	GO:0001829	trophectodermal cell differentiation
0.61	GO:0046697	decidualization
0.59	GO:0060711	labyrinthine layer development

0.61	GO:0003700	DNA binding transcription factor activity
0.61	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.54	GO:0003713	transcription coactivator activity
0.51	GO:0008134	transcription factor binding
0.45	GO:0070412	R-SMAD binding
0.45	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.43	GO:0031625	ubiquitin protein ligase binding
0.42	GO:0003682	chromatin binding
0.42	GO:0005096	GTPase activator activity
0.42	GO:0042803	protein homodimerization activity

0.65	GO:0035976	transcription factor AP-1 complex
0.53	GO:0031981	nuclear lumen
0.50	GO:0000785	chromatin
0.43	GO:0017053	transcriptional repressor complex
0.35	GO:0005829	cytosol
0.32	GO:0042025	host cell nucleus
0.30	GO:0016020	membrane

sp|P17301|ITA2_HUMAN
Integrin alpha-2
Search

ITGA2

0.97	Platelet membrane glycoprotein Ia

0.79	GO:0007229	integrin-mediated signaling pathway
0.71	GO:0007155	cell adhesion
0.60	GO:0006929	substrate-dependent cell migration
0.60	GO:0048333	mesodermal cell differentiation
0.59	GO:0038065	collagen-activated signaling pathway
0.47	GO:0010922	positive regulation of phosphatase activity
0.44	GO:0042127	regulation of cell proliferation
0.44	GO:0045123	cellular extravasation
0.43	GO:0033343	positive regulation of collagen binding
0.43	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway

0.65	GO:0098639	collagen binding involved in cell-matrix adhesion
0.60	GO:0038064	collagen receptor activity
0.59	GO:0001540	amyloid-beta binding
0.42	GO:0019903	protein phosphatase binding
0.41	GO:0043236	laminin binding
0.40	GO:0005178	integrin binding
0.39	GO:0046982	protein heterodimerization activity
0.37	GO:0001618	virus receptor activity
0.37	GO:0043395	heparan sulfate proteoglycan binding
0.35	GO:0046872	metal ion binding

0.80	GO:0008305	integrin complex
0.61	GO:0045178	basal part of cell
0.59	GO:0009897	external side of plasma membrane
0.59	GO:0005925	focal adhesion
0.40	GO:0043679	axon terminus
0.40	GO:0030424	axon
0.39	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0005634	nucleus
0.35	GO:0043204	perikaryon
0.35	GO:0001669	acrosomal vesicle

sp|P17302|CXA1_HUMAN
Gap junction alpha-1 protein
Search

GJA1

0.64	Gap junction alpha-1 protein (Fragment)

0.80	GO:0007507	heart development
0.75	GO:0007267	cell-cell signaling
0.55	GO:0055085	transmembrane transport
0.54	GO:0010644	cell communication by electrical coupling
0.51	GO:0060156	milk ejection reflex
0.51	GO:0010643	cell communication by chemical coupling
0.50	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization
0.50	GO:0030308	negative regulation of cell growth
0.50	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
0.49	GO:0002070	epithelial cell maturation

0.57	GO:0022857	transmembrane transporter activity
0.48	GO:0097110	scaffold protein binding
0.48	GO:1990782	protein tyrosine kinase binding
0.47	GO:0048487	beta-tubulin binding
0.44	GO:0004871	signal transducer activity
0.44	GO:0005102	receptor binding
0.39	GO:0030165	PDZ domain binding
0.38	GO:0071253	connexin binding
0.38	GO:0017124	SH3 domain binding
0.38	GO:0097718	disordered domain specific binding

0.84	GO:0005922	connexin complex
0.56	GO:0014704	intercalated disc
0.48	GO:0016328	lateral plasma membrane
0.47	GO:0005913	cell-cell adherens junction
0.47	GO:0016324	apical plasma membrane
0.46	GO:0005654	nucleoplasm
0.46	GO:0043292	contractile fiber
0.46	GO:0005882	intermediate filament
0.44	GO:0012505	endomembrane system
0.43	GO:0005739	mitochondrion

sp|P17342|ANPRC_HUMAN
Atrial natriuretic peptide receptor 3
Search

NPR3

0.94	Atrial natriuretic peptide clearance receptor

0.59	GO:0002158	osteoclast proliferation
0.58	GO:0035810	positive regulation of urine volume
0.57	GO:0033688	regulation of osteoblast proliferation
0.54	GO:0008217	regulation of blood pressure
0.53	GO:0001501	skeletal system development
0.46	GO:0007165	signal transduction
0.45	GO:0060038	cardiac muscle cell proliferation
0.41	GO:0030157	pancreatic juice secretion
0.41	GO:0051000	positive regulation of nitric-oxide synthase activity
0.40	GO:0007194	negative regulation of adenylate cyclase activity

0.62	GO:0016941	natriuretic peptide receptor activity
0.59	GO:0031404	chloride ion binding
0.58	GO:0017046	peptide hormone binding
0.52	GO:0042803	protein homodimerization activity
0.39	GO:0008528	G-protein coupled peptide receptor activity
0.36	GO:0004383	guanylate cyclase activity
0.34	GO:0004672	protein kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0043234	protein complex
0.38	GO:0070062	extracellular exosome
0.36	GO:0005887	integral component of plasma membrane
0.33	GO:0005622	intracellular

0.36

GO:0004383

sp|P17405|ASM_HUMAN
Sphingomyelin phosphodiesterase
Search

SMPD1

0.67	Sphingomyelin phosphodiesterase

0.82	GO:0006685	sphingomyelin catabolic process
0.61	GO:0023021	termination of signal transduction
0.58	GO:0046513	ceramide biosynthetic process
0.57	GO:0035307	positive regulation of protein dephosphorylation
0.56	GO:0043407	negative regulation of MAP kinase activity
0.40	GO:0042220	response to cocaine
0.38	GO:0043065	positive regulation of apoptotic process
0.36	GO:0006687	glycosphingolipid metabolic process
0.35	GO:0007399	nervous system development
0.34	GO:0007165	signal transduction

0.81	GO:0004767	sphingomyelin phosphodiesterase activity
0.60	GO:0016798	hydrolase activity, acting on glycosyl bonds
0.51	GO:0046872	metal ion binding
0.34	GO:0015054	gastrin receptor activity
0.34	GO:0005515	protein binding

0.54	GO:0005764	lysosome
0.52	GO:0005768	endosome
0.52	GO:0005615	extracellular space
0.43	GO:0005886	plasma membrane
0.40	GO:0042599	lamellar body
0.37	GO:1903561	extracellular vesicle
0.37	GO:0044437	vacuolar part
0.35	GO:0045121	membrane raft
0.34	GO:0098588	bounding membrane of organelle
0.34	GO:0043233	organelle lumen

0.81	EC:3.1.4.12	GO:0004767
0.81	KEGG:R02541	GO:0004767

sp|P17480|UBF1_HUMAN
Nucleolar transcription factor 1
Search

UBTF

0.89	Nucleolar transcription factor 1

0.47	GO:0006360	transcription by RNA polymerase I
0.43	GO:0045943	positive regulation of transcription by RNA polymerase I
0.42	GO:1902659	regulation of glucose mediated signaling pathway
0.41	GO:0006354	DNA-templated transcription, elongation
0.41	GO:0000183	chromatin silencing at rDNA
0.41	GO:1990830	cellular response to leukemia inhibitory factor
0.36	GO:0006353	DNA-templated transcription, termination
0.36	GO:0006352	DNA-templated transcription, initiation

0.55	GO:0003677	DNA binding
0.48	GO:0097110	scaffold protein binding
0.45	GO:0003682	chromatin binding
0.45	GO:0001067	regulatory region nucleic acid binding
0.36	GO:0003723	RNA binding

0.61	GO:0005634	nucleus
0.42	GO:0031974	membrane-enclosed lumen
0.40	GO:0043232	intracellular non-membrane-bounded organelle
0.39	GO:0044446	intracellular organelle part

sp|P17481|HXB8_HUMAN
Homeobox protein Hox-B8
Search

HOXB8

0.88	Homeobox protein Hox-B8

0.67	GO:0007275	multicellular organism development
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.55	GO:0007625	grooming behavior
0.54	GO:0019233	sensory perception of pain
0.54	GO:0045638	negative regulation of myeloid cell differentiation
0.53	GO:0008344	adult locomotory behavior
0.51	GO:0009653	anatomical structure morphogenesis
0.51	GO:1902679	negative regulation of RNA biosynthetic process

0.63	GO:0043565	sequence-specific DNA binding
0.59	GO:0003700	DNA binding transcription factor activity
0.36	GO:0001012	RNA polymerase II regulatory region DNA binding
0.35	GO:0003690	double-stranded DNA binding
0.33	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.49	GO:0031974	membrane-enclosed lumen
0.44	GO:0044446	intracellular organelle part
0.41	GO:0015630	microtubule cytoskeleton

sp|P17482|HXB9_HUMAN
Homeobox protein Hox-B9
Search

0.78	Homeobox protein Hox-B9

0.64	GO:0007275	multicellular organism development
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0060070	canonical Wnt signaling pathway
0.56	GO:0006351	transcription, DNA-templated
0.55	GO:0060326	cell chemotaxis
0.52	GO:1902680	positive regulation of RNA biosynthetic process
0.39	GO:0008344	adult locomotory behavior
0.39	GO:0007338	single fertilization

0.64	GO:0043565	sequence-specific DNA binding
0.54	GO:0001012	RNA polymerase II regulatory region DNA binding
0.51	GO:0003690	double-stranded DNA binding
0.38	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.35	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.34	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.52	GO:0005667	transcription factor complex
0.49	GO:0031974	membrane-enclosed lumen
0.45	GO:0005739	mitochondrion
0.44	GO:0044446	intracellular organelle part
0.35	GO:0043232	intracellular non-membrane-bounded organelle

sp|P17483|HXB4_HUMAN
Homeobox protein Hox-B4
Search

HOXB4

0.89	Homeobox protein Hox-B4

0.68	GO:0007275	multicellular organism development
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.54	GO:2000738	positive regulation of stem cell differentiation
0.53	GO:0048103	somatic stem cell division
0.53	GO:0002011	morphogenesis of an epithelial sheet
0.51	GO:0048863	stem cell differentiation
0.51	GO:1902680	positive regulation of RNA biosynthetic process
0.50	GO:0008283	cell proliferation

0.64	GO:0043565	sequence-specific DNA binding
0.60	GO:0003700	DNA binding transcription factor activity
0.46	GO:0071837	HMG box domain binding
0.45	GO:0035326	enhancer binding
0.43	GO:0001012	RNA polymerase II regulatory region DNA binding
0.42	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.49	GO:0005813	centrosome
0.35	GO:0043233	organelle lumen

sp|P17509|HXB6_HUMAN
Homeobox protein Hox-B6
Search

HOXB6

0.95	Homeobox protein Hox-B6

0.67	GO:0007275	multicellular organism development
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.54	GO:0034101	erythrocyte homeostasis
0.49	GO:0009653	anatomical structure morphogenesis
0.39	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
0.38	GO:0006366	transcription by RNA polymerase II
0.38	GO:0051254	positive regulation of RNA metabolic process
0.38	GO:0010557	positive regulation of macromolecule biosynthetic process

0.64	GO:0043565	sequence-specific DNA binding
0.60	GO:0003700	DNA binding transcription factor activity
0.38	GO:0001012	RNA polymerase II regulatory region DNA binding
0.37	GO:0003690	double-stranded DNA binding
0.34	GO:0003723	RNA binding
0.34	GO:0005515	protein binding
0.33	GO:0003714	transcription corepressor activity

0.60	GO:0005634	nucleus
0.43	GO:0005829	cytosol
0.43	GO:0031974	membrane-enclosed lumen
0.39	GO:0044446	intracellular organelle part
0.32	GO:0012505	endomembrane system
0.32	GO:0031090	organelle membrane
0.32	GO:0031975	envelope
0.30	GO:0016021	integral component of membrane

sp|P17516|AK1C4_HUMAN
Aldo-keto reductase family 1 member C4
Search

0.96	3-hydroxyhexobarbital dehydrogenase

0.53	GO:0055114	oxidation-reduction process
0.50	GO:0044597	daunorubicin metabolic process
0.49	GO:0071395	cellular response to jasmonic acid stimulus
0.48	GO:0044598	doxorubicin metabolic process
0.46	GO:0008202	steroid metabolic process
0.44	GO:0071799	cellular response to prostaglandin D stimulus
0.44	GO:1900053	negative regulation of retinoic acid biosynthetic process
0.43	GO:0016488	farnesol catabolic process
0.43	GO:2000224	regulation of testosterone biosynthetic process
0.43	GO:0042574	retinal metabolic process

0.54	GO:0016491	oxidoreductase activity
0.41	GO:0032052	bile acid binding
0.35	GO:0015125	bile acid transmembrane transporter activity
0.34	GO:0005496	steroid binding
0.34	GO:0070401	NADP+ binding
0.34	GO:0070402	NADPH binding
0.33	GO:0005515	protein binding

0.39	GO:0070062	extracellular exosome
0.38	GO:0005829	cytosol
0.37	GO:0005634	nucleus

0.54

GO:0016491

sp|P17535|JUND_HUMAN
Transcription factor jun-D
Search

0.91	Transcription factor jun-D

0.64	GO:0006357	regulation of transcription by RNA polymerase II
0.53	GO:0009612	response to mechanical stimulus
0.53	GO:0071277	cellular response to calcium ion
0.52	GO:0051591	response to cAMP
0.52	GO:0045597	positive regulation of cell differentiation
0.51	GO:0045893	positive regulation of transcription, DNA-templated
0.50	GO:0042127	regulation of cell proliferation
0.49	GO:0071495	cellular response to endogenous stimulus
0.49	GO:0032496	response to lipopolysaccharide
0.49	GO:0010941	regulation of cell death

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.53	GO:0001067	regulatory region nucleic acid binding
0.51	GO:0003713	transcription coactivator activity
0.51	GO:0008134	transcription factor binding
0.47	GO:0019899	enzyme binding
0.46	GO:0070412	R-SMAD binding
0.43	GO:0003682	chromatin binding
0.42	GO:0005096	GTPase activator activity
0.42	GO:0042803	protein homodimerization activity

0.56	GO:0005634	nucleus
0.53	GO:0005667	transcription factor complex
0.48	GO:0000785	chromatin
0.46	GO:0070013	intracellular organelle lumen
0.44	GO:0017053	transcriptional repressor complex
0.37	GO:0032993	protein-DNA complex
0.36	GO:0005829	cytosol
0.32	GO:0030529	intracellular ribonucleoprotein complex

sp|P17538|CTRB1_HUMAN
Chymotrypsinogen B
Search

0.83	Chymotrypsinogen B

0.61	GO:0006508	proteolysis
0.43	GO:0007586	digestion
0.38	GO:0022617	extracellular matrix disassembly
0.36	GO:0009235	cobalamin metabolic process
0.35	GO:0032094	response to food
0.35	GO:0007584	response to nutrient
0.35	GO:0043434	response to peptide hormone
0.34	GO:0043065	positive regulation of apoptotic process
0.34	GO:0034097	response to cytokine
0.34	GO:0030163	protein catabolic process

0.69	GO:0004252	serine-type endopeptidase activity
0.36	GO:0097655	serpin family protein binding

0.41	GO:0005615	extracellular space
0.35	GO:0097180	serine protease inhibitor complex
0.34	GO:0005764	lysosome

0.69

GO:0004252

sp|P17540|KCRS_HUMAN
Creatine kinase S-type, mitochondrial
Search

CKMT2

0.97	Mitochondrial creatine kinase s-type

0.56	GO:0016310	phosphorylation
0.40	GO:0032091	negative regulation of protein binding
0.39	GO:0043066	negative regulation of apoptotic process
0.38	GO:0006600	creatine metabolic process
0.37	GO:0007519	skeletal muscle tissue development
0.37	GO:0006599	phosphagen metabolic process
0.35	GO:0006936	muscle contraction
0.35	GO:0021549	cerebellum development
0.35	GO:0007507	heart development
0.35	GO:0048565	digestive tract development

0.59	GO:0016301	kinase activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor
0.36	GO:1901612	cardiolipin binding
0.34	GO:0042803	protein homodimerization activity
0.34	GO:0008270	zinc ion binding
0.33	GO:0003676	nucleic acid binding

0.48	GO:0005739	mitochondrion
0.39	GO:0043209	myelin sheath
0.39	GO:0019866	organelle inner membrane
0.37	GO:0070062	extracellular exosome
0.35	GO:0043204	perikaryon
0.30	GO:0044425	membrane part

0.41

EC:2.7.3

GO:0016775

sp|P17542|TAL1_HUMAN
T-cell acute lymphocytic leukemia protein 1
Search

TAL1

0.53	Stem cell leukemia protein SCL

0.63	GO:0060217	hemangioblast cell differentiation
0.63	GO:0060375	regulation of mast cell differentiation
0.62	GO:0060018	astrocyte fate commitment
0.62	GO:0030221	basophil differentiation
0.61	GO:0043249	erythrocyte maturation
0.61	GO:0060216	definitive hemopoiesis
0.61	GO:0021527	spinal cord association neuron differentiation
0.61	GO:0060218	hematopoietic stem cell differentiation
0.60	GO:0035855	megakaryocyte development
0.60	GO:0030220	platelet formation

0.68	GO:0046983	protein dimerization activity
0.60	GO:0070888	E-box binding
0.59	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.58	GO:0042826	histone deacetylase binding
0.57	GO:0001085	RNA polymerase II transcription factor binding
0.54	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.54	GO:0003682	chromatin binding

0.63	GO:0033193	Lsd1/2 complex
0.56	GO:0000118	histone deacetylase complex
0.53	GO:0005667	transcription factor complex
0.53	GO:0000790	nuclear chromatin
0.30	GO:0016020	membrane

sp|P17544|ATF7_HUMAN
Cyclic AMP-dependent transcription factor ATF-7
Search

ATF7

0.87	Cyclic AMP-dependent transcription factor ATF-7

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.38	GO:1902679	negative regulation of RNA biosynthetic process
0.36	GO:0006351	transcription, DNA-templated
0.35	GO:0032915	positive regulation of transforming growth factor beta2 production
0.35	GO:0110024	positive regulation of cardiac muscle myoblast proliferation
0.35	GO:1902110	positive regulation of mitochondrial membrane permeability involved in apoptotic process
0.35	GO:0060612	adipose tissue development
0.35	GO:0031573	intra-S DNA damage checkpoint

0.60	GO:0003700	DNA binding transcription factor activity
0.48	GO:0003676	nucleic acid binding
0.45	GO:0051019	mitogen-activated protein kinase binding
0.42	GO:0008134	transcription factor binding
0.35	GO:0046872	metal ion binding
0.34	GO:0004402	histone acetyltransferase activity
0.34	GO:0003682	chromatin binding

0.45	GO:0034399	nuclear periphery
0.38	GO:0005654	nucleoplasm
0.34	GO:0035861	site of double-strand break
0.34	GO:0005741	mitochondrial outer membrane
0.30	GO:0031224	intrinsic component of membrane

0.34

EC:2.3.1.48

GO:0004402

sp|P17568|NDUB7_HUMAN
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Search

NDUFB7

0.91	NADH dehydrogenase ubiquinone 1 beta subcomplex subunit 7

0.56	GO:0032981	mitochondrial respiratory chain complex I assembly
0.53	GO:0055114	oxidation-reduction process
0.34	GO:0006119	oxidative phosphorylation

0.69

GO:0008137

NADH dehydrogenase (ubiquinone) activity

0.61	GO:0005739	mitochondrion
0.55	GO:0045271	respiratory chain complex I
0.54	GO:0031970	organelle envelope lumen
0.49	GO:1990204	oxidoreductase complex
0.46	GO:0019866	organelle inner membrane

0.69

EC:1.6.5.3

GO:0008137

sp|P17600|SYN1_HUMAN
Synapsin-1
Search

SYN1

0.91	Synapsin IIb

0.82	GO:0099643	signal release from synapse
0.82	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.76	GO:0006836	neurotransmitter transport
0.72	GO:0001505	regulation of neurotransmitter levels
0.69	GO:0051649	establishment of localization in cell
0.56	GO:0097479	synaptic vesicle localization
0.38	GO:0048172	regulation of short-term neuronal synaptic plasticity
0.33	GO:0051588	regulation of neurotransmitter transport
0.32	GO:1903530	regulation of secretion by cell
0.32	GO:1902803	regulation of synaptic vesicle transport

0.53	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0019901	protein kinase binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0003779	actin binding
0.39	GO:0048306	calcium-dependent protein binding
0.36	GO:0046983	protein dimerization activity
0.33	GO:0046872	metal ion binding
0.31	GO:0005215	transporter activity

0.82	GO:0008021	synaptic vesicle
0.60	GO:0099501	exocytic vesicle membrane
0.58	GO:0014069	postsynaptic density
0.58	GO:0043209	myelin sheath
0.57	GO:0000795	synaptonemal complex
0.56	GO:0048786	presynaptic active zone
0.54	GO:0030424	axon
0.50	GO:0005856	cytoskeleton
0.42	GO:0031201	SNARE complex
0.41	GO:0030054	cell junction

sp|P17612|KAPCA_HUMAN
cAMP-dependent protein kinase catalytic subunit alpha
Search

PRKACA

0.83	cAMP-dependent protein kinase catalytic subunit alpha

0.62	GO:0006468	protein phosphorylation
0.59	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
0.56	GO:0001843	neural tube closure
0.56	GO:0070613	regulation of protein processing
0.51	GO:2000810	regulation of bicellular tight junction assembly
0.51	GO:0071374	cellular response to parathyroid hormone stimulus
0.50	GO:0048240	sperm capacitation
0.50	GO:0034605	cellular response to heat
0.50	GO:0071333	cellular response to glucose stimulus
0.49	GO:0071158	positive regulation of cell cycle arrest

0.69	GO:0004674	protein serine/threonine kinase activity
0.54	GO:0031625	ubiquitin protein ligase binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0034237	protein kinase A regulatory subunit binding
0.49	GO:0060089	molecular transducer activity
0.48	GO:0004712	protein serine/threonine/tyrosine kinase activity
0.47	GO:0000287	magnesium ion binding

0.58	GO:0097546	ciliary base
0.57	GO:0045171	intercellular bridge
0.53	GO:0005813	centrosome
0.51	GO:0005952	cAMP-dependent protein kinase complex
0.50	GO:0036126	sperm flagellum
0.50	GO:0001669	acrosomal vesicle
0.50	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0005829	cytosol
0.49	GO:0044853	plasma membrane raft
0.48	GO:0043197	dendritic spine

0.69

GO:0004674

sp|P17643|TYRP1_HUMAN
5,6-dihydroxyindole-2-carboxylic acid oxidase
Search

TYRP1

0.95	56-dihydroxyindole-2-carboxylic acid oxidase variant

0.57	GO:0048023	positive regulation of melanin biosynthetic process
0.56	GO:0043438	acetoacetic acid metabolic process
0.55	GO:0032438	melanosome organization
0.55	GO:0030318	melanocyte differentiation
0.53	GO:0006582	melanin metabolic process
0.53	GO:0055114	oxidation-reduction process
0.40	GO:0003406	retinal pigment epithelium development
0.40	GO:0097066	response to thyroid hormone
0.39	GO:0046189	phenol-containing compound biosynthetic process
0.38	GO:0044550	secondary metabolite biosynthetic process

0.54	GO:0016491	oxidoreductase activity
0.54	GO:0046872	metal ion binding
0.48	GO:0042803	protein homodimerization activity
0.48	GO:0046982	protein heterodimerization activity

0.55	GO:0033162	melanosome membrane
0.53	GO:0030669	clathrin-coated endocytic vesicle membrane
0.50	GO:0010008	endosome membrane
0.30	GO:0016021	integral component of membrane

0.54

GO:0016491

sp|P17655|CAN2_HUMAN
Calpain-2 catalytic subunit
Search

CAPN2

0.86	Calpain-2 catalytic subunit

0.75	GO:0051493	regulation of cytoskeleton organization
0.61	GO:0006508	proteolysis
0.54	GO:0071230	cellular response to amino acid stimulus
0.54	GO:0007520	myoblast fusion
0.51	GO:0001824	blastocyst development
0.47	GO:0044257	cellular protein catabolic process
0.38	GO:0001666	response to hypoxia
0.37	GO:0051604	protein maturation
0.36	GO:0022617	extracellular matrix disassembly
0.34	GO:0007586	digestion

0.82	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.70	GO:0005509	calcium ion binding
0.38	GO:1990782	protein tyrosine kinase binding
0.37	GO:0046982	protein heterodimerization activity
0.36	GO:0008092	cytoskeletal protein binding

0.55	GO:0031143	pseudopodium
0.54	GO:0097038	perinuclear endoplasmic reticulum
0.51	GO:0045121	membrane raft
0.50	GO:0005764	lysosome
0.47	GO:0005794	Golgi apparatus
0.47	GO:0000785	chromatin
0.46	GO:0005829	cytosol
0.43	GO:0005634	nucleus
0.42	GO:0030425	dendrite
0.42	GO:0005886	plasma membrane

sp|P17658|KCNA6_HUMAN
Potassium voltage-gated channel subfamily A member 6
Search

KCNA6

0.79	Potassium voltage-gated channel subfamily A member 6

0.77	GO:0051260	protein homooligomerization
0.76	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport
0.51	GO:0086052	membrane repolarization during SA node cell action potential
0.51	GO:0086050	membrane repolarization during bundle of His cell action potential
0.51	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential
0.50	GO:0060081	membrane hyperpolarization
0.49	GO:0086091	regulation of heart rate by cardiac conduction
0.47	GO:0043266	regulation of potassium ion transport
0.46	GO:0019229	regulation of vasoconstriction

0.78	GO:0005249	voltage-gated potassium channel activity
0.49	GO:0051393	alpha-actinin binding
0.48	GO:0097110	scaffold protein binding
0.48	GO:0019870	potassium channel inhibitor activity
0.46	GO:0019901	protein kinase binding
0.44	GO:0030955	potassium ion binding
0.35	GO:0005102	receptor binding
0.33	GO:0030246	carbohydrate binding
0.33	GO:0016757	transferase activity, transferring glycosyl groups

0.78	GO:0008076	voltage-gated potassium channel complex
0.56	GO:0043679	axon terminus
0.54	GO:0030424	axon
0.48	GO:0014704	intercalated disc
0.46	GO:0045121	membrane raft
0.38	GO:0046691	intracellular canaliculus
0.36	GO:0030018	Z disc
0.36	GO:0005794	Golgi apparatus
0.36	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0005783	endoplasmic reticulum

0.33

EC:2.4

GO:0016757

sp|P17661|DESM_HUMAN
Desmin
Search

DES

0.97	Muscle-specific intermediate filament desmin (Predicted)

0.58	GO:0045109	intermediate filament organization
0.47	GO:0006936	muscle contraction
0.47	GO:0007517	muscle organ development
0.46	GO:0007626	locomotory behavior
0.44	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling
0.43	GO:0045214	sarcomere organization
0.43	GO:0060047	heart contraction
0.42	GO:0014706	striated muscle tissue development
0.36	GO:0045107	intermediate filament polymerization
0.36	GO:0033275	actin-myosin filament sliding

0.62	GO:0005198	structural molecule activity
0.50	GO:0042802	identical protein binding
0.49	GO:0008092	cytoskeletal protein binding
0.33	GO:0004674	protein serine/threonine kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.79	GO:0005882	intermediate filament
0.59	GO:0030018	Z disc
0.58	GO:0005916	fascia adherens
0.58	GO:0097512	cardiac myofibril
0.57	GO:0042383	sarcolemma
0.56	GO:0031594	neuromuscular junction
0.45	GO:0005634	nucleus
0.44	GO:0097433	dense body
0.36	GO:0070062	extracellular exosome
0.35	GO:0005921	gap junction

0.33

GO:0004674

sp|P17676|CEBPB_HUMAN
CCAAT/enhancer-binding protein beta
Search

CEBPB

0.94	CCAAT enhancer binding protein beta

0.63	GO:0072574	hepatocyte proliferation
0.62	GO:0045600	positive regulation of fat cell differentiation
0.62	GO:0097421	liver regeneration
0.62	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
0.62	GO:0060850	regulation of transcription involved in cell fate commitment
0.61	GO:0032753	positive regulation of interleukin-4 production
0.61	GO:0045669	positive regulation of osteoblast differentiation
0.61	GO:0050873	brown fat cell differentiation
0.60	GO:0042130	negative regulation of T cell proliferation
0.60	GO:0045408	regulation of interleukin-6 biosynthetic process

0.61	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.60	GO:0035035	histone acetyltransferase binding
0.59	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
0.59	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.58	GO:0042826	histone deacetylase binding
0.56	GO:0019900	kinase binding
0.56	GO:0042803	protein homodimerization activity
0.55	GO:0044389	ubiquitin-like protein ligase binding
0.54	GO:0003682	chromatin binding
0.53	GO:0046982	protein heterodimerization activity

0.58	GO:0016363	nuclear matrix
0.56	GO:0000779	condensed chromosome, centromeric region
0.53	GO:0000790	nuclear chromatin
0.52	GO:0005654	nucleoplasm
0.45	GO:0036488	CHOP-C/EBP complex
0.40	GO:0005737	cytoplasm
0.35	GO:0005730	nucleolus
0.34	GO:0035189	Rb-E2F complex
0.32	GO:0005886	plasma membrane

0.34

GO:0004677

sp|P17677|NEUM_HUMAN
Neuromodulin
Search

GAP43

0.92	Growth associated protein 43

0.78	GO:0040008	regulation of growth
0.58	GO:0016198	axon choice point recognition
0.58	GO:0051489	regulation of filopodium assembly
0.55	GO:0010001	glial cell differentiation
0.54	GO:0045165	cell fate commitment
0.42	GO:0042246	tissue regeneration
0.40	GO:0007339	binding of sperm to zona pellucida
0.38	GO:0031103	axon regeneration
0.36	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway

0.46	GO:0005516	calmodulin binding
0.41	GO:0035727	lysophosphatidic acid binding
0.40	GO:0001786	phosphatidylserine binding
0.39	GO:1901981	phosphatidylinositol phosphate binding

0.62	GO:0031527	filopodium membrane
0.57	GO:0014069	postsynaptic density
0.55	GO:0043005	neuron projection
0.46	GO:0030427	site of polarized growth
0.44	GO:0030054	cell junction
0.39	GO:0005737	cytoplasm
0.37	GO:0097060	synaptic membrane
0.34	GO:0043025	neuronal cell body
0.34	GO:0098793	presynapse

sp|P17693|HLAG_HUMAN
HLA class I histocompatibility antigen, alpha chain G
Search

HLA-G

0.41	Patr class I histocompatibility antigen, alpha chain G

0.46	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
0.44	GO:0002767	immune response-inhibiting cell surface receptor signaling pathway
0.44	GO:2001199	negative regulation of dendritic cell differentiation
0.44	GO:0002666	positive regulation of T cell tolerance induction
0.44	GO:0045591	positive regulation of regulatory T cell differentiation
0.43	GO:0006968	cellular defense response
0.43	GO:0060337	type I interferon signaling pathway
0.43	GO:0060333	interferon-gamma-mediated signaling pathway
0.43	GO:0002478	antigen processing and presentation of exogenous peptide antigen
0.43	GO:0032735	positive regulation of interleukin-12 production

0.48	GO:0042605	peptide antigen binding
0.43	GO:0005102	receptor binding
0.40	GO:0042803	protein homodimerization activity

0.46	GO:0042612	MHC class I protein complex
0.43	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane
0.43	GO:0030670	phagocytic vesicle membrane
0.43	GO:0055038	recycling endosome membrane
0.42	GO:0031901	early endosome membrane
0.41	GO:0012507	ER to Golgi transport vesicle membrane
0.40	GO:0000139	Golgi membrane
0.38	GO:0005576	extracellular region

sp|P17706|PTN2_HUMAN
Tyrosine-protein phosphatase non-receptor type 2
Search

PTPN2

0.74	Tyrosine-protein phosphatase non-receptor type

0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.57	GO:1902206	negative regulation of interleukin-2-mediated signaling pathway
0.57	GO:1902215	negative regulation of interleukin-4-mediated signaling pathway
0.57	GO:1902233	negative regulation of positive thymic T cell selection
0.57	GO:0070104	negative regulation of interleukin-6-mediated signaling pathway
0.56	GO:1902227	negative regulation of macrophage colony-stimulating factor signaling pathway
0.56	GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway
0.55	GO:1903899	positive regulation of PERK-mediated unfolded protein response
0.55	GO:0060331	negative regulation of response to interferon-gamma
0.55	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway

0.74	GO:0004725	protein tyrosine phosphatase activity
0.55	GO:0097677	STAT family protein binding
0.52	GO:0030971	receptor tyrosine kinase binding
0.52	GO:0005178	integrin binding
0.51	GO:0019905	syntaxin binding
0.33	GO:0003677	DNA binding

0.52	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.47	GO:0005654	nucleoplasm
0.46	GO:0005829	cytosol
0.46	GO:0005783	endoplasmic reticulum
0.40	GO:0005886	plasma membrane
0.35	GO:0031965	nuclear membrane
0.30	GO:0016021	integral component of membrane

0.74

GO:0004725

sp|P17707|DCAM_HUMAN
S-adenosylmethionine decarboxylase proenzyme
Search

AMD1

0.56	S-adenosylmethionine decarboxylase proenzyme

0.83	GO:0006597	spermine biosynthetic process
0.76	GO:0008295	spermidine biosynthetic process
0.68	GO:0006557	S-adenosylmethioninamine biosynthetic process
0.37	GO:0001701	in utero embryonic development
0.34	GO:0046500	S-adenosylmethionine metabolic process

0.80	GO:0004014	adenosylmethionine decarboxylase activity
0.49	GO:0019810	putrescine binding
0.33	GO:0005515	protein binding

0.43

GO:0005829

cytosol

0.80	EC:4.1.1.50	GO:0004014
0.80	KEGG:R00178	GO:0004014

sp|P17735|ATTY_HUMAN
Tyrosine aminotransferase
Search

TAT

0.87	Tyrosine aminotransferase

0.71	GO:0009074	aromatic amino acid family catabolic process
0.55	GO:0006103	2-oxoglutarate metabolic process
0.54	GO:0006570	tyrosine metabolic process
0.51	GO:0006536	glutamate metabolic process
0.50	GO:1901606	alpha-amino acid catabolic process
0.48	GO:0009058	biosynthetic process
0.38	GO:0051384	response to glucocorticoid
0.38	GO:0006558	L-phenylalanine metabolic process
0.38	GO:0046689	response to mercury ion
0.37	GO:0042737	drug catabolic process

0.85	GO:0070547	L-tyrosine aminotransferase activity
0.65	GO:0030170	pyridoxal phosphate binding
0.38	GO:0070546	L-phenylalanine aminotransferase activity
0.38	GO:0016597	amino acid binding
0.34	GO:0005515	protein binding

0.45	GO:0005739	mitochondrion
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|P17752|TPH1_HUMAN
Tryptophan 5-hydroxylase 1
Search

TPH1

0.94	Tryptophan hydroxylase

0.85	GO:0042427	serotonin biosynthetic process
0.68	GO:0009072	aromatic amino acid family metabolic process
0.55	GO:0046849	bone remodeling
0.55	GO:0045600	positive regulation of fat cell differentiation
0.55	GO:0061377	mammary gland lobule development
0.52	GO:0055114	oxidation-reduction process
0.40	GO:0035902	response to immobilization stress
0.39	GO:0030279	negative regulation of ossification
0.39	GO:0007623	circadian rhythm
0.35	GO:0006586	indolalkylamine metabolic process

0.85	GO:0004510	tryptophan 5-monooxygenase activity
0.62	GO:0005506	iron ion binding

0.41	GO:0043005	neuron projection
0.38	GO:0005737	cytoplasm

0.85

EC:1.14.16.4

GO:0004510

sp|P17787|ACHB2_HUMAN
Neuronal acetylcholine receptor subunit beta-2
Search

CHRNB2

0.91	Neuronal nicotinic acetylcholine receptor beta 2 subunit

0.80	GO:0060079	excitatory postsynaptic potential
0.60	GO:0034220	ion transmembrane transport
0.50	GO:0035094	response to nicotine
0.50	GO:0007274	neuromuscular synaptic transmission
0.49	GO:0060073	micturition
0.49	GO:0021771	lateral geniculate nucleus development
0.48	GO:0042320	regulation of circadian sleep/wake cycle, REM sleep
0.48	GO:0033603	positive regulation of dopamine secretion
0.48	GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep
0.48	GO:0001661	conditioned taste aversion

0.83	GO:0022848	acetylcholine-gated cation-selective channel activity
0.70	GO:0004888	transmembrane signaling receptor activity
0.48	GO:0042166	acetylcholine binding
0.40	GO:0046982	protein heterodimerization activity

0.79	GO:0045211	postsynaptic membrane
0.75	GO:0030054	cell junction
0.50	GO:0005892	acetylcholine-gated channel complex
0.45	GO:0009897	external side of plasma membrane
0.42	GO:0044853	plasma membrane raft
0.42	GO:0043204	perikaryon
0.41	GO:0030425	dendrite
0.41	GO:0030424	axon
0.34	GO:0005737	cytoplasm

sp|P17812|PYRG1_HUMAN
CTP synthase 1
Search

CTPS1

0.48	CTP synthase

0.76	GO:0044210	'de novo' CTP biosynthetic process
0.70	GO:0006541	glutamine metabolic process
0.57	GO:0042100	B cell proliferation
0.57	GO:0042098	T cell proliferation
0.35	GO:0015949	nucleobase-containing small molecule interconversion
0.34	GO:0042493	response to drug
0.33	GO:0035556	intracellular signal transduction

0.78	GO:0003883	CTP synthase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0042802	identical protein binding
0.33	GO:0016829	lyase activity

0.33	GO:0005829	cytosol
0.33	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

0.78

EC:6.3.4.2

GO:0003883

sp|P17813|EGLN_HUMAN
Endoglin
Search

ENG

0.97	Endoglin (Osler-Rendu-Weber syndrome 1)

0.67	GO:1905222	atrioventricular canal morphogenesis
0.65	GO:0003273	cell migration involved in endocardial cushion formation
0.65	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
0.65	GO:1905065	positive regulation of vascular smooth muscle cell differentiation
0.65	GO:0022009	central nervous system vasculogenesis
0.64	GO:0055009	atrial cardiac muscle tissue morphogenesis
0.64	GO:0097084	vascular smooth muscle cell development
0.64	GO:0060317	cardiac epithelial to mesenchymal transition
0.64	GO:0035912	dorsal aorta morphogenesis
0.64	GO:0048845	venous blood vessel morphogenesis

0.66	GO:0005114	type II transforming growth factor beta receptor binding
0.64	GO:0050431	transforming growth factor beta binding
0.63	GO:0034713	type I transforming growth factor beta receptor binding
0.63	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity
0.62	GO:0036122	BMP binding
0.57	GO:0005534	galactose binding
0.56	GO:0005539	glycosaminoglycan binding
0.55	GO:0042803	protein homodimerization activity
0.49	GO:0005024	transforming growth factor beta-activated receptor activity
0.40	GO:0015026	coreceptor activity

0.65	GO:0072563	endothelial microparticle
0.59	GO:0009897	external side of plasma membrane
0.57	GO:0043235	receptor complex
0.43	GO:0005925	focal adhesion
0.41	GO:0034673	inhibin-betaglycan-ActRII complex
0.37	GO:1902554	serine/threonine protein kinase complex
0.36	GO:0005887	integral component of plasma membrane
0.33	GO:0005578	proteinaceous extracellular matrix
0.33	GO:0005622	intracellular
0.33	GO:0070062	extracellular exosome

sp|P17844|DDX5_HUMAN
Probable ATP-dependent RNA helicase DDX5
Search

DDX5

0.83	Probable ATP-dependent RNA helicase DDX5

0.52	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
0.51	GO:0060765	regulation of androgen receptor signaling pathway
0.51	GO:0030520	intracellular estrogen receptor signaling pathway
0.51	GO:0000380	alternative mRNA splicing, via spliceosome
0.51	GO:0030521	androgen receptor signaling pathway
0.50	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
0.50	GO:0001837	epithelial to mesenchymal transition
0.49	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.47	GO:0061614	pri-miRNA transcription by RNA polymerase II
0.47	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA

0.67	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0050681	androgen receptor binding
0.51	GO:0003676	nucleic acid binding
0.49	GO:0035500	MH2 domain binding
0.47	GO:0070412	R-SMAD binding
0.46	GO:1990841	promoter-specific chromatin binding
0.46	GO:0043021	ribonucleoprotein complex binding

0.47	GO:0071141	SMAD protein complex
0.46	GO:0005681	spliceosomal complex
0.45	GO:0005730	nucleolus
0.39	GO:1902494	catalytic complex
0.38	GO:0031012	extracellular matrix
0.37	GO:0070062	extracellular exosome
0.35	GO:0005654	nucleoplasm
0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|P17858|PFKAL_HUMAN
ATP-dependent 6-phosphofructokinase, liver type
Search

PFKL

0.44	ATP-dependent 6-phosphofructokinase

0.79	GO:0006002	fructose 6-phosphate metabolic process
0.78	GO:0061615	glycolytic process through fructose-6-phosphate
0.55	GO:0046676	negative regulation of insulin secretion
0.55	GO:0009749	response to glucose
0.54	GO:0030388	fructose 1,6-bisphosphate metabolic process
0.49	GO:0051259	protein oligomerization
0.37	GO:1990830	cellular response to leukemia inhibitory factor
0.36	GO:0061718	glucose catabolic process to pyruvate
0.36	GO:0006735	NADH regeneration
0.35	GO:0043312	neutrophil degranulation

0.79	GO:0003872	6-phosphofructokinase activity
0.59	GO:0070095	fructose-6-phosphate binding
0.58	GO:0070061	fructose binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0019900	kinase binding
0.50	GO:0046872	metal ion binding
0.49	GO:0042802	identical protein binding
0.38	GO:0045296	cadherin binding

0.57	GO:0005945	6-phosphofructokinase complex
0.36	GO:0070062	extracellular exosome
0.36	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0034774	secretory granule lumen
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:2.7.1.11

GO:0003872

sp|P17861|XBP1_HUMAN
X-box-binding protein 1
Search

XBP1

0.93	X-box-binding protein 1

0.58	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
0.56	GO:0060691	epithelial cell maturation involved in salivary gland development
0.56	GO:1900100	positive regulation of plasma cell differentiation
0.56	GO:1903489	positive regulation of lactation
0.55	GO:0001889	liver development
0.55	GO:0035470	positive regulation of vascular wound healing
0.55	GO:1990418	response to insulin-like growth factor stimulus
0.54	GO:2000347	positive regulation of hepatocyte proliferation
0.54	GO:0035356	cellular triglyceride homeostasis
0.54	GO:0045348	positive regulation of MHC class II biosynthetic process

0.60	GO:0003700	DNA binding transcription factor activity
0.51	GO:0001158	enhancer sequence-specific DNA binding
0.51	GO:0001085	RNA polymerase II transcription factor binding
0.51	GO:0001047	core promoter binding
0.47	GO:0046982	protein heterodimerization activity
0.46	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.41	GO:0031490	chromatin DNA binding
0.40	GO:0002020	protease binding
0.39	GO:0031625	ubiquitin protein ligase binding
0.39	GO:0019901	protein kinase binding

0.45	GO:0005783	endoplasmic reticulum
0.44	GO:0005634	nucleus
0.39	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.38	GO:0031984	organelle subcompartment
0.37	GO:0005829	cytosol
0.35	GO:0098793	presynapse
0.34	GO:0070013	intracellular organelle lumen
0.30	GO:0016021	integral component of membrane

sp|P17900|SAP3_HUMAN
Ganglioside GM2 activator
Search

GM2A

0.96	Ganglioside GM2 activator

0.85	GO:0006689	ganglioside catabolic process
0.72	GO:0043085	positive regulation of catalytic activity
0.62	GO:0050885	neuromuscular process controlling balance
0.60	GO:0019915	lipid storage
0.59	GO:0007611	learning or memory
0.58	GO:0009313	oligosaccharide catabolic process
0.40	GO:0006869	lipid transport
0.40	GO:0051336	regulation of hydrolase activity
0.37	GO:0043312	neutrophil degranulation
0.36	GO:0061025	membrane fusion

0.74	GO:0008047	enzyme activator activity
0.57	GO:0004563	beta-N-acetylhexosaminidase activity
0.41	GO:0005319	lipid transporter activity
0.36	GO:0008289	lipid binding

0.47	GO:0005739	mitochondrion
0.46	GO:0005889	potassium:proton exchanging ATPase complex
0.44	GO:0045179	apical cortex
0.43	GO:0005764	lysosome
0.41	GO:0009898	cytoplasmic side of plasma membrane
0.40	GO:0070062	extracellular exosome
0.37	GO:0034774	secretory granule lumen
0.37	GO:0005775	vacuolar lumen

0.57

EC:3.2.1.52

GO:0004563

sp|P17927|CR1_HUMAN
Complement receptor type 1
Search

0.81	Complement receptor type 1

0.67	GO:0042100	B cell proliferation
0.65	GO:0030183	B cell differentiation
0.30	GO:0045959	negative regulation of complement activation, classical pathway
0.30	GO:0045957	negative regulation of complement activation, alternative pathway
0.30	GO:0002366	leukocyte activation involved in immune response
0.30	GO:0002684	positive regulation of immune system process
0.30	GO:0002768	immune response-regulating cell surface receptor signaling pathway
0.30	GO:0044238	primary metabolic process
0.30	GO:0002443	leukocyte mediated immunity
0.30	GO:0010952	positive regulation of peptidase activity

0.68	GO:0001848	complement binding
0.59	GO:0042803	protein homodimerization activity
0.46	GO:0003677	DNA binding
0.30	GO:0104005	hijacked molecular function
0.30	GO:0004877	complement component C3b receptor activity
0.30	GO:0001846	opsonin binding
0.30	GO:0001861	complement component C4b receptor activity

0.64	GO:0043235	receptor complex
0.38	GO:0005576	extracellular region
0.34	GO:0005737	cytoplasm
0.30	GO:0009986	cell surface
0.30	GO:0044459	plasma membrane part
0.30	GO:0016021	integral component of membrane
0.30	GO:0098588	bounding membrane of organelle
0.30	GO:0031982	vesicle
0.30	GO:0098805	whole membrane
0.30	GO:0043229	intracellular organelle

sp|P17931|LEG3_HUMAN
Galectin-3
Search

LGALS3

0.60

Galectin

0.59	GO:0048246	macrophage chemotaxis
0.59	GO:0048245	eosinophil chemotaxis
0.58	GO:0090280	positive regulation of calcium ion import
0.58	GO:0002548	monocyte chemotaxis
0.58	GO:0071677	positive regulation of mononuclear cell migration
0.57	GO:0070232	regulation of T cell apoptotic process
0.57	GO:0045806	negative regulation of endocytosis
0.57	GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors
0.57	GO:0030593	neutrophil chemotaxis
0.57	GO:0050918	positive chemotaxis

0.69	GO:0030246	carbohydrate binding
0.60	GO:0019863	IgE binding
0.58	GO:0042056	chemoattractant activity
0.57	GO:0043236	laminin binding
0.37	GO:0050785	advanced glycation end-product receptor activity
0.37	GO:0005544	calcium-dependent phospholipid binding
0.37	GO:0034988	Fc-gamma receptor I complex binding
0.36	GO:0005509	calcium ion binding
0.35	GO:0005178	integrin binding
0.35	GO:0003723	RNA binding

0.57	GO:0001772	immunological synapse
0.51	GO:0031012	extracellular matrix
0.45	GO:0005634	nucleus
0.45	GO:0031966	mitochondrial membrane
0.45	GO:0019866	organelle inner membrane
0.39	GO:0097386	glial cell projection
0.38	GO:1990724	galectin complex
0.38	GO:0005615	extracellular space
0.38	GO:1903561	extracellular vesicle
0.37	GO:0009897	external side of plasma membrane

0.31

GO:0016787

sp|P17936|IBP3_HUMAN
Insulin-like growth factor-binding protein 3
Search

IGFBP3

0.94	Insulin like growth factor binding protein 3

0.70	GO:0001558	regulation of cell growth
0.59	GO:0014912	negative regulation of smooth muscle cell migration
0.58	GO:0044342	type B pancreatic cell proliferation
0.58	GO:0045663	positive regulation of myoblast differentiation
0.58	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
0.57	GO:0048662	negative regulation of smooth muscle cell proliferation
0.55	GO:0001649	osteoblast differentiation
0.54	GO:0010906	regulation of glucose metabolic process
0.53	GO:0043666	regulation of phosphoprotein phosphatase activity
0.53	GO:0043065	positive regulation of apoptotic process

0.83	GO:0005520	insulin-like growth factor binding
0.60	GO:0008160	protein tyrosine phosphatase activator activity
0.58	GO:0001968	fibronectin binding
0.33	GO:0046872	metal ion binding

0.65	GO:0005576	extracellular region
0.59	GO:0036454	growth factor complex
0.46	GO:0005634	nucleus
0.36	GO:0031982	vesicle
0.36	GO:0005788	endoplasmic reticulum lumen
0.35	GO:0000792	heterochromatin

sp|P17947|SPI1_HUMAN
Transcription factor PU.1
Search

SPI1

0.97	SFFV proviral integration 1

0.61	GO:0030225	macrophage differentiation
0.60	GO:0030851	granulocyte differentiation
0.60	GO:0044027	hypermethylation of CpG island
0.60	GO:0045646	regulation of erythrocyte differentiation
0.59	GO:0045347	negative regulation of MHC class II biosynthetic process
0.59	GO:0090241	negative regulation of histone H4 acetylation
0.59	GO:0061614	pri-miRNA transcription by RNA polymerase II
0.58	GO:1902262	apoptotic process involved in blood vessel morphogenesis
0.58	GO:0030218	erythrocyte differentiation
0.58	GO:0002320	lymphoid progenitor cell differentiation

0.64	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.59	GO:0051525	NFAT protein binding
0.55	GO:0035326	enhancer binding
0.55	GO:0001047	core promoter binding
0.54	GO:0001085	RNA polymerase II transcription factor binding
0.52	GO:0001012	RNA polymerase II regulatory region DNA binding
0.49	GO:0003690	double-stranded DNA binding
0.35	GO:0003723	RNA binding

0.61	GO:0005634	nucleus
0.50	GO:0000785	chromatin
0.48	GO:0031974	membrane-enclosed lumen
0.34	GO:0005667	transcription factor complex
0.30	GO:0016020	membrane

sp|P17948|VGFR1_HUMAN
Vascular endothelial growth factor receptor 1
Search

FLT1

0.56	Kinase insert domain receptor like

0.82	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.82	GO:0038084	vascular endothelial growth factor signaling pathway
0.75	GO:0018108	peptidyl-tyrosine phosphorylation
0.65	GO:1905563	negative regulation of vascular endothelial cell proliferation
0.64	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
0.63	GO:0010863	positive regulation of phospholipase C activity
0.63	GO:0002548	monocyte chemotaxis
0.63	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
0.61	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
0.60	GO:0045766	positive regulation of angiogenesis

0.82	GO:0005021	vascular endothelial growth factor-activated receptor activity
0.67	GO:0036332	placental growth factor-activated receptor activity
0.61	GO:0019838	growth factor binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0042802	identical protein binding
0.37	GO:0019903	protein phosphatase binding
0.36	GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity

0.63	GO:0005887	integral component of plasma membrane
0.57	GO:0043235	receptor complex
0.54	GO:0015629	actin cytoskeleton
0.38	GO:0005768	endosome
0.38	GO:0005925	focal adhesion
0.37	GO:0005615	extracellular space
0.35	GO:0005654	nucleoplasm

0.36

GO:0004716

sp|P17980|PRS6A_HUMAN
26S protease regulatory subunit 6A
Search

PSMC3

0.78	Testicular secretory protein Li 42

0.81	GO:1901800	positive regulation of proteasomal protein catabolic process
0.70	GO:0030163	protein catabolic process
0.53	GO:0052472	modulation by host of symbiont transcription
0.52	GO:0006508	proteolysis
0.50	GO:0045944	positive regulation of transcription by RNA polymerase II
0.49	GO:0046782	regulation of viral transcription
0.49	GO:0001824	blastocyst development
0.48	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly
0.47	GO:2000144	positive regulation of DNA-templated transcription, initiation
0.46	GO:0034976	response to endoplasmic reticulum stress

0.82	GO:0036402	proteasome-activating ATPase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.50	GO:0008233	peptidase activity
0.47	GO:0042802	identical protein binding
0.46	GO:0017025	TBP-class protein binding
0.37	GO:0033130	acetylcholine receptor binding
0.37	GO:0043495	protein membrane anchor

0.55	GO:1905369	endopeptidase complex
0.50	GO:0000932	P-body
0.47	GO:0043234	protein complex
0.44	GO:0005634	nucleus
0.43	GO:0044445	cytosolic part
0.42	GO:0070013	intracellular organelle lumen
0.39	GO:0044446	intracellular organelle part
0.35	GO:0045202	synapse
0.35	GO:0101002	ficolin-1-rich granule
0.35	GO:0031983	vesicle lumen

0.50

GO:0008233

sp|P17987|TCPA_HUMAN
T-complex protein 1 subunit alpha
Search

TCP1

0.77	T-complex protein 1 subunit alpha

0.65	GO:0006457	protein folding
0.61	GO:0044053	translocation of peptides or proteins into host cell cytoplasm
0.60	GO:0090670	RNA localization to Cajal body
0.59	GO:2000109	regulation of macrophage apoptotic process
0.59	GO:1904869	regulation of protein localization to Cajal body
0.59	GO:1904851	positive regulation of establishment of protein localization to telomere
0.58	GO:1904874	positive regulation of telomerase RNA localization to Cajal body
0.57	GO:0051973	positive regulation of telomerase activity
0.57	GO:0007339	binding of sperm to zona pellucida
0.57	GO:0032212	positive regulation of telomere maintenance via telomerase

0.67	GO:0051082	unfolded protein binding
0.53	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0031625	ubiquitin protein ligase binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0044183	protein binding involved in protein folding
0.34	GO:0003723	RNA binding
0.33	GO:0005216	ion channel activity

0.58	GO:0002199	zona pellucida receptor complex
0.58	GO:0005832	chaperonin-containing T-complex
0.57	GO:0000242	pericentriolar material
0.55	GO:0001669	acrosomal vesicle
0.55	GO:0005720	nuclear heterochromatin
0.55	GO:0043209	myelin sheath
0.54	GO:0044297	cell body
0.50	GO:0005874	microtubule
0.49	GO:0005794	Golgi apparatus
0.37	GO:0070062	extracellular exosome

sp|P18031|PTN1_HUMAN
Tyrosine-protein phosphatase non-receptor type 1
Search

PTPN1

0.75	Tyrosine-protein phosphatase non-receptor type

0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.58	GO:1903898	negative regulation of PERK-mediated unfolded protein response
0.58	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway
0.58	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway
0.57	GO:2000646	positive regulation of receptor catabolic process
0.57	GO:0036498	IRE1-mediated unfolded protein response
0.56	GO:1902235	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.56	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
0.56	GO:0007257	activation of JUN kinase activity
0.55	GO:0008286	insulin receptor signaling pathway

0.75	GO:0004725	protein tyrosine phosphatase activity
0.55	GO:0030971	receptor tyrosine kinase binding
0.55	GO:0046875	ephrin receptor binding
0.53	GO:0045296	cadherin binding
0.45	GO:0008270	zinc ion binding
0.41	GO:0005158	insulin receptor binding
0.41	GO:0051721	protein phosphatase 2A binding
0.37	GO:0097677	STAT family protein binding
0.35	GO:0005178	integrin binding
0.35	GO:0019905	syntaxin binding

0.57	GO:0097443	sorting endosome
0.56	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane
0.53	GO:0005769	early endosome
0.42	GO:0005886	plasma membrane
0.38	GO:0005829	cytosol
0.35	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.34	GO:0031225	anchored component of membrane
0.34	GO:0005654	nucleoplasm
0.30	GO:0016021	integral component of membrane

0.75

GO:0004725

sp|P18054|LOX12_HUMAN
Arachidonate 12-lipoxygenase, 12S-type
Search

0.93	Arachidonate 12-lipoxygenase

0.67	GO:0019372	lipoxygenase pathway
0.64	GO:0019369	arachidonic acid metabolic process
0.63	GO:2001303	lipoxin A4 biosynthetic process
0.57	GO:1901751	leukotriene A4 metabolic process
0.57	GO:2001304	lipoxin B4 metabolic process
0.56	GO:0090331	negative regulation of platelet aggregation
0.56	GO:0043651	linoleic acid metabolic process
0.55	GO:0061436	establishment of skin barrier
0.54	GO:0010656	negative regulation of muscle cell apoptotic process
0.53	GO:0055114	oxidation-reduction process

0.75	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
0.62	GO:0005506	iron ion binding
0.48	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.46	GO:0047977	hepoxilin-epoxide hydrolase activity
0.42	GO:0051120	hepoxilin A3 synthase activity
0.36	GO:0097260	eoxin A4 synthase activity
0.36	GO:0005509	calcium ion binding
0.35	GO:0019870	potassium channel inhibitor activity
0.34	GO:0005515	protein binding
0.33	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)

0.52	GO:0042383	sarcolemma
0.51	GO:0005829	cytosol
0.47	GO:0005811	lipid droplet
0.47	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.37	GO:0070062	extracellular exosome
0.35	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.75

EC:1.13.11

GO:0016702

sp|P18065|IBP2_HUMAN
Insulin-like growth factor-binding protein 2
Search

IGFBP2

0.96	Insulin like growth factor binding protein 2

0.71	GO:0001558	regulation of cell growth
0.60	GO:0042104	positive regulation of activated T cell proliferation
0.53	GO:0032868	response to insulin
0.53	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway
0.41	GO:0032501	multicellular organismal process
0.41	GO:0010226	response to lithium ion
0.41	GO:0032502	developmental process
0.40	GO:0048640	negative regulation of developmental growth
0.40	GO:0032355	response to estradiol
0.40	GO:0043627	response to estrogen

0.83	GO:0005520	insulin-like growth factor binding
0.35	GO:0005102	receptor binding
0.33	GO:0016746	transferase activity, transferring acyl groups

0.66	GO:0005576	extracellular region
0.39	GO:0016324	apical plasma membrane
0.38	GO:0031410	cytoplasmic vesicle
0.30	GO:0016021	integral component of membrane

0.33

GO:0016746

sp|P18074|ERCC2_HUMAN
TFIIH basal transcription factor complex helicase XPD subunit
Search

ERCC2

0.92	General transcription and DNA repair factor IIH helicase subunit XPD

0.73	GO:0006289	nucleotide-excision repair
0.70	GO:0032508	DNA duplex unwinding
0.52	GO:0032289	central nervous system myelin formation
0.51	GO:0035315	hair cell differentiation
0.51	GO:0009650	UV protection
0.51	GO:0048820	hair follicle maturation
0.50	GO:0040016	embryonic cleavage
0.50	GO:0043249	erythrocyte maturation
0.50	GO:0060218	hematopoietic stem cell differentiation
0.49	GO:0030282	bone mineralization

0.72	GO:0004003	ATP-dependent DNA helicase activity
0.55	GO:0030554	adenyl nucleotide binding
0.55	GO:0003677	DNA binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0047485	protein N-terminus binding
0.50	GO:0043139	5'-3' DNA helicase activity
0.50	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.50	GO:0008022	protein C-terminus binding

0.61	GO:0005634	nucleus
0.53	GO:0071817	MMXD complex
0.51	GO:0150005	enzyme activator complex
0.51	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
0.48	GO:0000428	DNA-directed RNA polymerase complex
0.48	GO:0005667	transcription factor complex
0.45	GO:0070013	intracellular organelle lumen
0.44	GO:0005829	cytosol
0.38	GO:0005703	polytene chromosome puff
0.38	GO:0005705	polytene chromosome interband

0.50

EC:2.7.11.23

GO:0008353

sp|P18075|BMP7_HUMAN
Bone morphogenetic protein 7
Search

BMP7

0.96	Bone morphogenetic protein 7

0.74	GO:0010469	regulation of receptor activity
0.60	GO:1905069	allantois development
0.60	GO:0072134	nephrogenic mesenchyme morphogenesis
0.60	GO:0072136	metanephric mesenchymal cell proliferation involved in metanephros development
0.59	GO:0072040	negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
0.59	GO:0021502	neural fold elevation formation
0.59	GO:0072133	metanephric mesenchyme morphogenesis
0.59	GO:1905294	positive regulation of neural crest cell differentiation
0.59	GO:1905310	regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
0.59	GO:0072125	negative regulation of glomerular mesangial cell proliferation

0.77	GO:0008083	growth factor activity
0.51	GO:0070700	BMP receptor binding
0.49	GO:0005160	transforming growth factor beta receptor binding
0.47	GO:0005125	cytokine activity
0.40	GO:0008201	heparin binding
0.35	GO:0042803	protein homodimerization activity
0.35	GO:0046982	protein heterodimerization activity

0.65	GO:0005576	extracellular region
0.38	GO:0031982	vesicle

sp|P18077|RL35A_HUMAN
60S ribosomal protein L35a
Search

RPL35A

0.68	Ribosomal protein L35

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.52	GO:0042273	ribosomal large subunit biogenesis
0.43	GO:0016072	rRNA metabolic process
0.42	GO:0030218	erythrocyte differentiation
0.41	GO:0043009	chordate embryonic development
0.36	GO:0007155	cell adhesion
0.35	GO:0006508	proteolysis

0.64	GO:0003735	structural constituent of ribosome
0.38	GO:0000049	tRNA binding
0.36	GO:0004222	metalloendopeptidase activity
0.34	GO:0035091	phosphatidylinositol binding
0.33	GO:0030234	enzyme regulator activity
0.33	GO:0005515	protein binding

0.61	GO:0005840	ribosome
0.47	GO:0044445	cytosolic part
0.41	GO:0044446	intracellular organelle part
0.37	GO:0005739	mitochondrion
0.35	GO:0031012	extracellular matrix
0.34	GO:0070062	extracellular exosome
0.34	GO:1905369	endopeptidase complex
0.33	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

0.36

GO:0004222

sp|P18084|ITB5_HUMAN
Integrin beta-5
Search

ITGB5

0.68	Integrin beta

0.80	GO:0007229	integrin-mediated signaling pathway
0.72	GO:0007155	cell adhesion
0.60	GO:0043149	stress fiber assembly
0.58	GO:0035987	endodermal cell differentiation
0.56	GO:0007179	transforming growth factor beta receptor signaling pathway
0.37	GO:0060055	angiogenesis involved in wound healing
0.37	GO:0007044	cell-substrate junction assembly
0.37	GO:0030168	platelet activation
0.36	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.36	GO:0030334	regulation of cell migration

0.65	GO:0004872	receptor activity
0.36	GO:0104005	hijacked molecular function
0.36	GO:0005515	protein binding
0.34	GO:0044877	macromolecular complex binding
0.34	GO:0005509	calcium ion binding

0.81	GO:0008305	integrin complex
0.52	GO:0009986	cell surface
0.37	GO:0005925	focal adhesion
0.35	GO:0045335	phagocytic vesicle
0.35	GO:0070062	extracellular exosome
0.35	GO:0031252	cell leading edge
0.32	GO:0035866	alphav-beta3 integrin-PKCalpha complex
0.32	GO:0071133	alpha9-beta1 integrin-ADAM8 complex
0.31	GO:0016324	apical plasma membrane
0.31	GO:0098552	side of membrane

sp|P18085|ARF4_HUMAN
ADP-ribosylation factor 4
Search

ARF4

0.90	ADP-ribosylation factor 4

0.55	GO:0031584	activation of phospholipase D activity
0.54	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.54	GO:0060996	dendritic spine development
0.53	GO:0045176	apical protein localization
0.53	GO:0061512	protein localization to cilium
0.53	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
0.52	GO:0007612	learning
0.52	GO:0006471	protein ADP-ribosylation
0.52	GO:2000377	regulation of reactive oxygen species metabolic process
0.49	GO:0043066	negative regulation of apoptotic process

0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0005154	epidermal growth factor receptor binding
0.36	GO:0005085	guanyl-nucleotide exchange factor activity
0.35	GO:0017137	Rab GTPase binding
0.34	GO:0003924	GTPase activity

0.53	GO:0032587	ruffle membrane
0.52	GO:0043197	dendritic spine
0.48	GO:0005794	Golgi apparatus
0.46	GO:0005829	cytosol
0.38	GO:0070062	extracellular exosome
0.36	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0031012	extracellular matrix
0.34	GO:0070382	exocytic vesicle
0.30	GO:0016021	integral component of membrane

sp|P18089|ADA2B_HUMAN
Alpha-2B adrenergic receptor
Search

ADRA2B

0.79	LOW QUALITY PROTEIN: alpha-2B adrenergic receptor

0.85	GO:0071875	adrenergic receptor signaling pathway
0.85	GO:0006940	regulation of smooth muscle contraction
0.85	GO:0019229	regulation of vasoconstriction
0.84	GO:0030168	platelet activation
0.44	GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
0.43	GO:0032148	activation of protein kinase B activity
0.41	GO:0045666	positive regulation of neuron differentiation
0.41	GO:0043410	positive regulation of MAPK cascade
0.41	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.39	GO:0007267	cell-cell signaling

0.86	GO:0004938	alpha2-adrenergic receptor activity
0.43	GO:0051379	epinephrine binding
0.34	GO:0005515	protein binding
0.34	GO:0004222	metalloendopeptidase activity
0.33	GO:0008270	zinc ion binding

0.51	GO:0005886	plasma membrane
0.33	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

0.34

GO:0004222

sp|P18124|RL7_HUMAN
60S ribosomal protein L7
Search

RPL7

0.65	Ribosomal protein L7

0.51	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.50	GO:0002181	cytoplasmic translation
0.38	GO:0051726	regulation of cell cycle
0.36	GO:0097421	liver regeneration
0.35	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.35	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.34	GO:0019083	viral transcription
0.34	GO:0006413	translational initiation
0.34	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.33	GO:0007186	G-protein coupled receptor signaling pathway

0.44	GO:0003735	structural constituent of ribosome
0.43	GO:0003723	RNA binding
0.41	GO:0042803	protein homodimerization activity
0.36	GO:0003677	DNA binding
0.34	GO:0004984	olfactory receptor activity
0.33	GO:0004930	G-protein coupled receptor activity

0.60	GO:0005840	ribosome
0.50	GO:0044445	cytosolic part
0.47	GO:0005844	polysome
0.43	GO:0044446	intracellular organelle part
0.37	GO:0005925	focal adhesion
0.37	GO:0070062	extracellular exosome
0.36	GO:0031672	A band
0.35	GO:0031974	membrane-enclosed lumen
0.35	GO:0005634	nucleus
0.32	GO:0005886	plasma membrane

sp|P18146|EGR1_HUMAN
Early growth response protein 1
Search

EGR1

0.82	Early growth response protein 1-B

0.62	GO:0050722	regulation of interleukin-1 beta biosynthetic process
0.61	GO:0045362	positive regulation of interleukin-1 biosynthetic process
0.61	GO:2000182	regulation of progesterone biosynthetic process
0.61	GO:0098758	response to interleukin-8
0.60	GO:0044849	estrous cycle
0.60	GO:0045080	positive regulation of chemokine biosynthetic process
0.59	GO:0046886	positive regulation of hormone biosynthetic process
0.59	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
0.59	GO:0002931	response to ischemia
0.59	GO:0032731	positive regulation of interleukin-1 beta production

0.62	GO:0044729	hemi-methylated DNA-binding
0.60	GO:0010385	double-stranded methylated DNA binding
0.58	GO:1990841	promoter-specific chromatin binding
0.58	GO:0035035	histone acetyltransferase binding
0.55	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.54	GO:0046872	metal ion binding
0.53	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.35	GO:0001046	core promoter sequence-specific DNA binding
0.34	GO:0008134	transcription factor binding

0.61	GO:0005634	nucleus
0.48	GO:0070013	intracellular organelle lumen
0.43	GO:0044446	intracellular organelle part
0.40	GO:0005737	cytoplasm

sp|P18206|VINC_HUMAN
Vinculin
Search

VCL

0.91	LOW QUALITY PROTEIN: vinculin

0.72	GO:0007155	cell adhesion
0.60	GO:0030032	lamellipodium assembly
0.59	GO:0034394	protein localization to cell surface
0.59	GO:0048675	axon extension
0.58	GO:0034333	adherens junction assembly
0.58	GO:0043297	apical junction assembly
0.55	GO:0030334	regulation of cell migration
0.55	GO:0002009	morphogenesis of an epithelium
0.48	GO:0099622	cardiac muscle cell membrane repolarization
0.48	GO:0086011	membrane repolarization during action potential

0.78	GO:0051015	actin filament binding
0.62	GO:0005198	structural molecule activity
0.60	GO:0045294	alpha-catenin binding
0.59	GO:0002162	dystroglycan binding
0.56	GO:0045296	cadherin binding
0.55	GO:0031625	ubiquitin protein ligase binding
0.46	GO:0051371	muscle alpha-actinin binding
0.46	GO:0017166	vinculin binding
0.45	GO:0097110	scaffold protein binding
0.42	GO:0042803	protein homodimerization activity

0.74	GO:0015629	actin cytoskeleton
0.61	GO:0005916	fascia adherens
0.61	GO:0043034	costamere
0.59	GO:0042383	sarcolemma
0.58	GO:0005925	focal adhesion
0.52	GO:0044430	cytoskeletal part
0.50	GO:0090636	outer dense plaque of desmosome
0.48	GO:0098723	skeletal muscle myofibril
0.46	GO:0090637	inner dense plaque of desmosome
0.46	GO:0005927	muscle tendon junction

sp|P18283|GPX2_HUMAN
Glutathione peroxidase 2
Search

GPX2

0.47	Glutathione peroxidase

0.71	GO:0006979	response to oxidative stress
0.69	GO:0098869	cellular oxidant detoxification
0.53	GO:0055114	oxidation-reduction process
0.50	GO:0009609	response to symbiotic bacterium
0.49	GO:0002862	negative regulation of inflammatory response to antigenic stimulus
0.48	GO:0001659	temperature homeostasis
0.48	GO:0051450	myoblast proliferation
0.47	GO:0010269	response to selenium ion
0.47	GO:0051702	interaction with symbiont
0.47	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

0.79	GO:0004602	glutathione peroxidase activity
0.44	GO:0017124	SH3 domain binding
0.37	GO:0003924	GTPase activity
0.36	GO:0005525	GTP binding
0.33	GO:0009055	electron transfer activity

0.47	GO:0097413	Lewy body
0.42	GO:0005829	cytosol
0.39	GO:0005739	mitochondrion
0.39	GO:0005615	extracellular space
0.38	GO:1903561	extracellular vesicle
0.33	GO:0070013	intracellular organelle lumen
0.33	GO:0005634	nucleus
0.32	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.79

EC:1.11.1.9

GO:0004602

sp|P18405|S5A1_HUMAN
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Search

SRD5A1

0.90	Steroid-5-alpha-reductase alpha polypeptide 1

0.69	GO:0008202	steroid metabolic process
0.53	GO:0055114	oxidation-reduction process
0.49	GO:0030540	female genitalia development
0.49	GO:0030539	male genitalia development
0.46	GO:0042446	hormone biosynthetic process
0.46	GO:0034754	cellular hormone metabolic process
0.43	GO:0042180	cellular ketone metabolic process
0.43	GO:0008610	lipid biosynthetic process
0.41	GO:0042747	circadian sleep/wake cycle, REM sleep
0.40	GO:0071394	cellular response to testosterone stimulus

0.78	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity
0.45	GO:0047751	cholestenone 5-alpha-reductase activity
0.38	GO:0070402	NADPH binding
0.37	GO:0033218	amide binding
0.34	GO:0050213	progesterone 5-alpha-reductase activity
0.34	GO:0009055	electron transfer activity
0.33	GO:0008519	ammonium transmembrane transporter activity
0.33	GO:0016779	nucleotidyltransferase activity

0.49	GO:0005737	cytoplasm
0.40	GO:0070852	cell body fiber
0.39	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.38	GO:0043209	myelin sheath
0.38	GO:0043025	neuronal cell body
0.38	GO:0031984	organelle subcompartment
0.37	GO:0031090	organelle membrane
0.36	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

0.78	EC:1.3.99.5	GO:0003865
0.45	KEGG:R02610	GO:0047751

sp|P18428|LBP_HUMAN
Lipopolysaccharide-binding protein
Search

LBP

0.97	Lipopolysaccharide binding protein (Fragment)

0.85	GO:0006953	acute-phase response
0.84	GO:0050829	defense response to Gram-negative bacterium
0.84	GO:0060265	positive regulation of respiratory burst involved in inflammatory response
0.83	GO:0045919	positive regulation of cytolysis
0.83	GO:0002281	macrophage activation involved in immune response
0.83	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
0.83	GO:0071223	cellular response to lipoteichoic acid
0.82	GO:0002232	leukocyte chemotaxis involved in inflammatory response
0.81	GO:0043032	positive regulation of macrophage activation
0.80	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process

0.84	GO:0070891	lipoteichoic acid binding
0.84	GO:0071723	lipopeptide binding
0.83	GO:0001530	lipopolysaccharide binding
0.65	GO:0005102	receptor binding

0.73	GO:0005615	extracellular space
0.69	GO:0009986	cell surface

sp|P18433|PTPRA_HUMAN
Receptor-type tyrosine-protein phosphatase alpha
Search

PTPRA

0.89	Receptor-type tyrosine-protein phosphatase alpha

0.72	GO:0035335	peptidyl-tyrosine dephosphorylation
0.51	GO:0008286	insulin receptor signaling pathway
0.43	GO:0060027	convergent extension involved in gastrulation
0.43	GO:0006468	protein phosphorylation
0.42	GO:0060041	retina development in camera-type eye
0.41	GO:0045859	regulation of protein kinase activity
0.36	GO:0048699	generation of neurons
0.35	GO:0048709	oligodendrocyte differentiation
0.34	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.34	GO:0010720	positive regulation of cell development

0.72	GO:0004725	protein tyrosine phosphatase activity
0.35	GO:0019198	transmembrane receptor protein phosphatase activity
0.35	GO:0005515	protein binding
0.34	GO:0044877	macromolecular complex binding
0.34	GO:0098772	molecular function regulator

0.48	GO:0043235	receptor complex
0.37	GO:0005763	mitochondrial small ribosomal subunit
0.36	GO:0070062	extracellular exosome
0.33	GO:0005887	integral component of plasma membrane

0.72

GO:0004725

sp|P18440|ARY1_HUMAN
Arylamine N-acetyltransferase 1
Search

0.62	Arylamine N-acetyltransferase

0.38	GO:0097068	response to thyroxine
0.37	GO:0001889	liver development
0.36	GO:0007568	aging
0.36	GO:0009410	response to xenobiotic stimulus
0.36	GO:1902475	L-alpha-amino acid transmembrane transport
0.34	GO:0070887	cellular response to chemical stimulus
0.34	GO:0048565	digestive tract development
0.34	GO:0032496	response to lipopolysaccharide
0.34	GO:0001666	response to hypoxia
0.30	GO:0044237	cellular metabolic process

0.67	GO:0016407	acetyltransferase activity
0.45	GO:0016410	N-acyltransferase activity
0.36	GO:0015179	L-amino acid transmembrane transporter activity
0.33	GO:0005515	protein binding

0.37	GO:0005829	cytosol
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.67

GO:0016407

sp|P18505|GBRB1_HUMAN
Gamma-aminobutyric acid receptor subunit beta-1
Search

GABRB1

0.86	Gamma-aminobutyric acid A receptor

0.59	GO:0007165	signal transduction
0.59	GO:0034220	ion transmembrane transport
0.51	GO:0006821	chloride transport
0.49	GO:0060384	innervation
0.49	GO:0090102	cochlea development
0.48	GO:0060119	inner ear receptor cell development
0.48	GO:0043524	negative regulation of neuron apoptotic process
0.47	GO:0007605	sensory perception of sound
0.45	GO:0071420	cellular response to histamine
0.42	GO:0032570	response to progesterone

0.82	GO:0004890	GABA-A receptor activity
0.74	GO:0005230	extracellular ligand-gated ion channel activity
0.55	GO:0099095	ligand-gated anion channel activity
0.51	GO:0005254	chloride channel activity
0.50	GO:0022835	transmitter-gated channel activity
0.42	GO:0050811	GABA receptor binding
0.32	GO:0003676	nucleic acid binding

0.59	GO:1902711	GABA-A receptor complex
0.55	GO:0005886	plasma membrane
0.41	GO:0034707	chloride channel complex
0.40	GO:0098794	postsynapse
0.40	GO:0030425	dendrite
0.40	GO:0030054	cell junction
0.39	GO:0005635	nuclear envelope
0.35	GO:0031410	cytoplasmic vesicle
0.35	GO:0012506	vesicle membrane
0.34	GO:0005829	cytosol

sp|P18507|GBRG2_HUMAN
Gamma-aminobutyric acid receptor subunit gamma-2
Search

GABRG2

0.95	Gamma-aminobutyric acid receptor subunit epsilon

0.85	GO:0007214	gamma-aminobutyric acid signaling pathway
0.77	GO:0006821	chloride transport
0.60	GO:0034220	ion transmembrane transport
0.56	GO:0071420	cellular response to histamine
0.52	GO:0030534	adult behavior
0.50	GO:0009791	post-embryonic development
0.50	GO:0007268	chemical synaptic transmission

0.84	GO:0004890	GABA-A receptor activity
0.75	GO:0005230	extracellular ligand-gated ion channel activity
0.50	GO:0005254	chloride channel activity
0.36	GO:0008503	benzodiazepine receptor activity
0.35	GO:0005515	protein binding

0.55	GO:0005886	plasma membrane
0.55	GO:1902711	GABA-A receptor complex
0.51	GO:0030424	axon
0.41	GO:0034707	chloride channel complex
0.40	GO:0098794	postsynapse
0.39	GO:0030425	dendrite
0.39	GO:0030054	cell junction
0.39	GO:0030659	cytoplasmic vesicle membrane
0.37	GO:0060077	inhibitory synapse
0.36	GO:0031252	cell leading edge

sp|P18509|PACA_HUMAN
Pituitary adenylate cyclase-activating polypeptide
Search

ADCYAP1

0.94	Pituitary adenylate cyclase-activating polypeptide

0.75	GO:0010469	regulation of receptor activity
0.60	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production
0.59	GO:0007218	neuropeptide signaling pathway
0.57	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.57	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.57	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.54	GO:0007399	nervous system development
0.54	GO:0045860	positive regulation of protein kinase activity
0.53	GO:0120036	plasma membrane bounded cell projection organization
0.53	GO:0043547	positive regulation of GTPase activity

0.79	GO:0005179	hormone activity
0.60	GO:0051428	peptide hormone receptor binding
0.44	GO:0005057	signal transducer activity, downstream of receptor
0.43	GO:0031858	pituitary adenylate cyclase-activating polypeptide receptor binding

0.66	GO:0005576	extracellular region
0.41	GO:0043195	terminal bouton
0.38	GO:0005622	intracellular
0.37	GO:0070852	cell body fiber
0.36	GO:0043204	perikaryon
0.30	GO:0031224	intrinsic component of membrane

sp|P18510|IL1RA_HUMAN
Interleukin-1 receptor antagonist protein
Search

IL1RN

0.82	Interleukin 1 receptor antagonist

0.79	GO:0006954	inflammatory response
0.75	GO:0010469	regulation of receptor activity
0.74	GO:0006955	immune response
0.65	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway
0.63	GO:0034115	negative regulation of heterotypic cell-cell adhesion
0.61	GO:0030073	insulin secretion
0.60	GO:0051384	response to glucocorticoid
0.52	GO:0031649	heat generation
0.50	GO:0019221	cytokine-mediated signaling pathway
0.47	GO:0006629	lipid metabolic process

0.85	GO:0005149	interleukin-1 receptor binding
0.80	GO:0005125	cytokine activity
0.71	GO:0005152	interleukin-1 receptor antagonist activity
0.34	GO:0005086	ARF guanyl-nucleotide exchange factor activity

0.73	GO:0005615	extracellular space
0.52	GO:0031982	vesicle
0.38	GO:0043230	extracellular organelle
0.34	GO:0005737	cytoplasm
0.33	GO:0005886	plasma membrane

sp|P18545|CNRG_HUMAN
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Search

PDE6G

0.96	Retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase subunit gamma

0.77	GO:0007601	visual perception
0.52	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
0.52	GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
0.50	GO:0000187	activation of MAPK activity
0.38	GO:0050896	response to stimulus
0.36	GO:0022400	regulation of rhodopsin mediated signaling pathway
0.36	GO:0043086	negative regulation of catalytic activity
0.35	GO:0198738	cell-cell signaling by wnt

0.85	GO:0030553	cGMP binding
0.78	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.39	GO:0030507	spectrin binding
0.36	GO:0004857	enzyme inhibitor activity
0.33	GO:0008270	zinc ion binding

0.38	GO:0097381	photoreceptor disc membrane
0.36	GO:0042622	photoreceptor outer segment membrane

0.78

EC:3.1.4.17

GO:0004114

sp|P18564|ITB6_HUMAN
Integrin beta-6
Search

ITGB6

0.58	Integrin beta

0.81	GO:0007160	cell-matrix adhesion
0.80	GO:0007229	integrin-mediated signaling pathway
0.54	GO:0038044	transforming growth factor-beta secretion
0.52	GO:0033627	cell adhesion mediated by integrin
0.48	GO:0006954	inflammatory response
0.37	GO:0060055	angiogenesis involved in wound healing
0.37	GO:0070527	platelet aggregation
0.37	GO:0007044	cell-substrate junction assembly
0.36	GO:0030334	regulation of cell migration
0.33	GO:0051806	entry into cell of other organism involved in symbiotic interaction

0.64	GO:0004872	receptor activity
0.50	GO:0005178	integrin binding
0.34	GO:0104005	hijacked molecular function
0.32	GO:0003723	RNA binding

0.80	GO:0008305	integrin complex
0.49	GO:0005925	focal adhesion
0.49	GO:0009897	external side of plasma membrane
0.48	GO:0005813	centrosome
0.45	GO:0005654	nucleoplasm
0.30	GO:1903561	extracellular vesicle
0.30	GO:0005615	extracellular space

sp|P18577|RHCE_HUMAN
Blood group Rh(CE) polypeptide
Search

RHCE

0.97	Rh blood group Rhce antigen variant

0.77	GO:0072488	ammonium transmembrane transport
0.35	GO:0015695	organic cation transport

0.77

GO:0008519

ammonium transmembrane transporter activity

0.34

GO:0005887

integral component of plasma membrane

sp|P18583|SON_HUMAN
Protein SON
Search

SON

0.97	SON DNA-binding protein isoform F (Predicted)

0.81	GO:0043484	regulation of RNA splicing
0.73	GO:0051726	regulation of cell cycle
0.56	GO:0000281	mitotic cytokinesis
0.55	GO:0043066	negative regulation of apoptotic process
0.54	GO:0050684	regulation of mRNA processing
0.54	GO:0000226	microtubule cytoskeleton organization
0.51	GO:0006397	mRNA processing
0.37	GO:0008380	RNA splicing
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:1903506	regulation of nucleic acid-templated transcription

0.63	GO:0050733	RS domain binding
0.59	GO:0003723	RNA binding
0.40	GO:0003677	DNA binding

0.56

GO:0016607

nuclear speck

sp|P18615|NELFE_HUMAN
Negative elongation factor E
Search

NELFE

0.90	Negative elongation factor complex member E

0.65	GO:1900364	negative regulation of mRNA polyadenylation
0.64	GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter
0.57	GO:0006414	translational elongation
0.49	GO:1902038	positive regulation of hematopoietic stem cell differentiation
0.46	GO:0051571	positive regulation of histone H3-K4 methylation
0.44	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.42	GO:0045944	positive regulation of transcription by RNA polymerase II
0.38	GO:0006368	transcription elongation from RNA polymerase II promoter
0.38	GO:0050434	positive regulation of viral transcription
0.37	GO:0008380	RNA splicing

0.58	GO:0003723	RNA binding
0.42	GO:0003682	chromatin binding
0.37	GO:0005515	protein binding

0.86	GO:0032021	NELF complex
0.60	GO:0016604	nuclear body
0.46	GO:0005886	plasma membrane

sp|P18621|RL17_HUMAN
60S ribosomal protein L17
Search

RPL17

0.64	W-linked ribosomal protein L17

0.60	GO:0043043	peptide biosynthetic process
0.55	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.52	GO:0009059	macromolecule biosynthetic process
0.37	GO:1990928	response to amino acid starvation
0.36	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
0.36	GO:0034198	cellular response to amino acid starvation
0.36	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.35	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.35	GO:0019083	viral transcription

0.64	GO:0003735	structural constituent of ribosome
0.35	GO:0070180	large ribosomal subunit rRNA binding
0.35	GO:0005515	protein binding

0.70	GO:0015934	large ribosomal subunit
0.37	GO:0022626	cytosolic ribosome
0.36	GO:0031672	A band
0.36	GO:0005844	polysome
0.35	GO:0005634	nucleus

sp|P18627|LAG3_HUMAN
Lymphocyte activation gene 3 protein
Search

LAG3

0.97	Lymphocyte activation gene 3

0.76	GO:0045085	negative regulation of interleukin-2 biosynthetic process
0.73	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
0.70	GO:0050868	negative regulation of T cell activation
0.60	GO:0007166	cell surface receptor signaling pathway
0.41	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.33	GO:0006955	immune response
0.33	GO:0007155	cell adhesion
0.32	GO:0006508	proteolysis

0.74	GO:0042289	MHC class II protein binding
0.59	GO:0004888	transmembrane signaling receptor activity
0.40	GO:0003823	antigen binding
0.34	GO:0015026	coreceptor activity
0.32	GO:0004252	serine-type endopeptidase activity

0.67	GO:0009897	external side of plasma membrane
0.30	GO:0016021	integral component of membrane

0.32

GO:0004252

sp|P18669|PGAM1_HUMAN
Phosphoglycerate mutase 1
Search

PGAM1

0.49	Phosphoglycerate mutase

0.68	GO:0006757	ATP generation from ADP
0.67	GO:0006090	pyruvate metabolic process
0.66	GO:0016052	carbohydrate catabolic process
0.65	GO:0019362	pyridine nucleotide metabolic process
0.54	GO:0043456	regulation of pentose-phosphate shunt
0.46	GO:0019319	hexose biosynthetic process
0.45	GO:0006006	glucose metabolic process
0.42	GO:0045730	respiratory burst
0.42	GO:0006110	regulation of glycolytic process
0.40	GO:0006941	striated muscle contraction

0.79	GO:0004082	bisphosphoglycerate mutase activity
0.75	GO:0004619	phosphoglycerate mutase activity
0.40	GO:0019901	protein kinase binding
0.35	GO:0016787	hydrolase activity
0.32	GO:0048037	cofactor binding

0.46	GO:0043209	myelin sheath
0.45	GO:0005829	cytosol
0.38	GO:0070062	extracellular exosome
0.35	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0034774	secretory granule lumen
0.35	GO:0097228	sperm principal piece
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.79

EC:5.4.2.4

GO:0004082

sp|P18754|RCC1_HUMAN
Regulator of chromosome condensation
Search

sp|P18825|ADA2C_HUMAN
Alpha-2C adrenergic receptor
Search

ADRA2C

0.91	Alpha-2 adrenergic receptor

0.85	GO:0071875	adrenergic receptor signaling pathway
0.84	GO:0006940	regulation of smooth muscle contraction
0.84	GO:0019229	regulation of vasoconstriction
0.83	GO:0030168	platelet activation
0.48	GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
0.47	GO:0051930	regulation of sensory perception of pain
0.46	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.46	GO:0045932	negative regulation of muscle contraction
0.46	GO:0032148	activation of protein kinase B activity
0.46	GO:1903524	positive regulation of blood circulation

0.85	GO:0004938	alpha2-adrenergic receptor activity
0.48	GO:0031694	alpha-2A adrenergic receptor binding
0.47	GO:0051379	epinephrine binding
0.43	GO:0042803	protein homodimerization activity
0.42	GO:0046982	protein heterodimerization activity

0.54	GO:0005886	plasma membrane
0.45	GO:0043679	axon terminus
0.44	GO:0030424	axon
0.38	GO:0005768	endosome
0.30	GO:0016021	integral component of membrane

sp|P18827|SDC1_HUMAN
Syndecan-1
Search

SDC1

0.79

Syndecan

0.73	GO:0042060	wound healing
0.63	GO:0048627	myoblast development
0.62	GO:1903553	positive regulation of extracellular exosome assembly
0.60	GO:1903543	positive regulation of exosomal secretion
0.57	GO:0060070	canonical Wnt signaling pathway
0.57	GO:0055002	striated muscle cell development
0.45	GO:0016477	cell migration
0.42	GO:0060009	Sertoli cell development
0.42	GO:0051591	response to cAMP
0.41	GO:0051384	response to glucocorticoid

0.57	GO:0008022	protein C-terminus binding
0.54	GO:0042802	identical protein binding
0.36	GO:0050840	extracellular matrix binding
0.33	GO:0003723	RNA binding
0.33	GO:0019838	growth factor binding
0.32	GO:0050694	galactose 3-O-sulfotransferase activity
0.32	GO:0005509	calcium ion binding

0.56	GO:0009897	external side of plasma membrane
0.44	GO:0044421	extracellular region part
0.40	GO:0031982	vesicle
0.40	GO:0005796	Golgi lumen
0.38	GO:0043202	lysosomal lumen
0.36	GO:0043234	protein complex
0.34	GO:0005887	integral component of plasma membrane
0.33	GO:0030424	axon

0.32

EC:2.8.2

GO:0050694

sp|P18846|ATF1_HUMAN
Cyclic AMP-dependent transcription factor ATF-1
Search

ATF1

0.93	Glial cell derived neurotrophic factor

0.69	GO:0006357	regulation of transcription by RNA polymerase II
0.53	GO:0006366	transcription by RNA polymerase II
0.51	GO:0045893	positive regulation of transcription, DNA-templated
0.42	GO:0032025	response to cobalt ion
0.41	GO:0045740	positive regulation of DNA replication
0.40	GO:0010976	positive regulation of neuron projection development
0.39	GO:0014070	response to organic cyclic compound
0.38	GO:0043623	cellular protein complex assembly

0.73	GO:0046982	protein heterodimerization activity
0.64	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.54	GO:0001012	RNA polymerase II regulatory region DNA binding
0.52	GO:0042802	identical protein binding
0.51	GO:0003690	double-stranded DNA binding
0.39	GO:0032403	protein complex binding
0.34	GO:0003723	RNA binding
0.30	GO:0003824	catalytic activity

0.61	GO:1990590	ATF1-ATF4 transcription factor complex
0.50	GO:0005654	nucleoplasm

sp|P18847|ATF3_HUMAN
Cyclic AMP-dependent transcription factor ATF-3
Search

ATF3

0.97	Cyclic AMP-dependent transcription factor ATF-3

0.71	GO:0006357	regulation of transcription by RNA polymerase II
0.62	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway
0.58	GO:0035914	skeletal muscle cell differentiation
0.58	GO:0034198	cellular response to amino acid starvation
0.58	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.57	GO:0030968	endoplasmic reticulum unfolded protein response
0.57	GO:0043620	regulation of DNA-templated transcription in response to stress
0.52	GO:0045892	negative regulation of transcription, DNA-templated
0.52	GO:0045893	positive regulation of transcription, DNA-templated
0.52	GO:0019319	hexose biosynthetic process

0.61	GO:0003700	DNA binding transcription factor activity
0.56	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.53	GO:0042803	protein homodimerization activity
0.52	GO:0046982	protein heterodimerization activity
0.37	GO:0003682	chromatin binding
0.35	GO:0003714	transcription corepressor activity

0.62	GO:1990622	CHOP-ATF3 complex
0.60	GO:0005634	nucleus
0.49	GO:0043233	organelle lumen
0.45	GO:0043232	intracellular non-membrane-bounded organelle
0.44	GO:0044446	intracellular organelle part
0.37	GO:0005667	transcription factor complex
0.30	GO:0016020	membrane

sp|P18848|ATF4_HUMAN
Cyclic AMP-dependent transcription factor ATF-4
Search

ATF4

0.96	Cyclic AMP-dependent transcription factor ATF-4

0.70	GO:0006357	regulation of transcription by RNA polymerase II
0.61	GO:1903351	cellular response to dopamine
0.60	GO:1903204	negative regulation of oxidative stress-induced neuron death
0.60	GO:0036499	PERK-mediated unfolded protein response
0.60	GO:0010575	positive regulation of vascular endothelial growth factor production
0.59	GO:0043620	regulation of DNA-templated transcription in response to stress
0.58	GO:0045943	positive regulation of transcription by RNA polymerase I
0.58	GO:0042789	mRNA transcription by RNA polymerase II
0.58	GO:0042149	cellular response to glucose starvation
0.58	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

0.61	GO:0043522	leucine zipper domain binding
0.61	GO:0003700	DNA binding transcription factor activity
0.57	GO:0001085	RNA polymerase II transcription factor binding
0.56	GO:0001046	core promoter sequence-specific DNA binding
0.54	GO:0019901	protein kinase binding
0.54	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.40	GO:0008022	protein C-terminus binding
0.37	GO:0046982	protein heterodimerization activity
0.36	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding

0.62	GO:1990617	CHOP-ATF4 complex
0.62	GO:1990589	ATF4-CREB1 transcription factor complex
0.62	GO:1990590	ATF1-ATF4 transcription factor complex
0.62	GO:1990037	Lewy body core
0.56	GO:0034399	nuclear periphery
0.54	GO:0005813	centrosome
0.54	GO:0043005	neuron projection
0.48	GO:0005737	cytoplasm
0.40	GO:0031256	leading edge membrane
0.40	GO:0031253	cell projection membrane

sp|P18850|ATF6A_HUMAN
Cyclic AMP-dependent transcription factor ATF-6 alpha
Search

ATF6

0.95	Cyclic AMP-dependent transcription factor ATF-6 alpha

0.84	GO:0030968	endoplasmic reticulum unfolded protein response
0.73	GO:0045944	positive regulation of transcription by RNA polymerase II
0.57	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress
0.55	GO:0001654	eye development
0.55	GO:0043065	positive regulation of apoptotic process
0.54	GO:0007601	visual perception
0.39	GO:0001666	response to hypoxia
0.36	GO:0006984	ER-nucleus signaling pathway
0.35	GO:0006366	transcription by RNA polymerase II
0.34	GO:0006457	protein folding

0.85	GO:0035497	cAMP response element binding
0.61	GO:0003700	DNA binding transcription factor activity
0.52	GO:0046982	protein heterodimerization activity
0.52	GO:0042802	identical protein binding
0.39	GO:0031625	ubiquitin protein ligase binding
0.36	GO:0003713	transcription coactivator activity
0.35	GO:0008138	protein tyrosine/serine/threonine phosphatase activity

0.70	GO:0005789	endoplasmic reticulum membrane
0.61	GO:0005634	nucleus
0.51	GO:0005794	Golgi apparatus
0.35	GO:0098588	bounding membrane of organelle
0.34	GO:0005829	cytosol
0.34	GO:0043233	organelle lumen
0.34	GO:0031967	organelle envelope
0.33	GO:0008537	proteasome activator complex
0.30	GO:0016021	integral component of membrane

0.35

EC:3.1.3

GO:0008138

sp|P18858|DNLI1_HUMAN
DNA ligase 1
Search

LIG1

0.47	Ligase I, DNA, ATP-dependent

0.79	GO:0051103	DNA ligation involved in DNA repair
0.66	GO:0071897	DNA biosynthetic process
0.65	GO:0006310	DNA recombination
0.65	GO:0006260	DNA replication
0.47	GO:0022616	DNA strand elongation
0.47	GO:0006284	base-excision repair
0.45	GO:1903047	mitotic cell cycle process
0.38	GO:0016070	RNA metabolic process
0.37	GO:0042542	response to hydrogen peroxide
0.37	GO:0006303	double-strand break repair via nonhomologous end joining

0.78	GO:0003910	DNA ligase (ATP) activity
0.54	GO:0003677	DNA binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0046872	metal ion binding
0.33	GO:0003700	DNA binding transcription factor activity

0.46	GO:0005654	nucleoplasm
0.40	GO:0005739	mitochondrion

0.78

EC:6.5.1.1

GO:0003910

sp|P18859|ATP5J_HUMAN
ATP synthase-coupling factor 6, mitochondrial
Search

ATP5J

0.95	ATP synthase-coupling factor 6, mitochondrial

0.70	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.70	GO:0006754	ATP biosynthetic process
0.40	GO:0021762	substantia nigra development
0.36	GO:0042407	cristae formation
0.36	GO:0046907	intracellular transport
0.35	GO:0006839	mitochondrial transport
0.35	GO:1904263	positive regulation of TORC1 signaling
0.35	GO:0048194	Golgi vesicle budding
0.34	GO:0050829	defense response to Gram-negative bacterium
0.34	GO:0015031	protein transport

0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.45	GO:0016887	ATPase activity
0.37	GO:0047624	adenosine-tetraphosphatase activity
0.33	GO:0005198	structural molecule activity
0.33	GO:0004386	helicase activity
0.33	GO:1901265	nucleoside phosphate binding
0.32	GO:0036094	small molecule binding

0.78	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
0.35	GO:0030127	COPII vesicle coat
0.34	GO:0000139	Golgi membrane
0.33	GO:0005840	ribosome

0.45

GO:0016887

sp|P18887|XRCC1_HUMAN
DNA repair protein XRCC1
Search

XRCC1

0.91	X-ray repair complementing defective repair in Chinese hamster cells 1

0.85	GO:0000012	single strand break repair
0.64	GO:1904877	positive regulation of DNA ligase activity
0.63	GO:1903518	positive regulation of single strand break repair
0.63	GO:0010836	negative regulation of protein ADP-ribosylation
0.62	GO:0061819	telomeric DNA-containing double minutes formation
0.62	GO:1905765	negative regulation of protection from non-homologous end joining at telomere
0.62	GO:0050882	voluntary musculoskeletal movement
0.60	GO:0033194	response to hydroperoxide
0.60	GO:1990414	replication-born double-strand break repair via sister chromatid exchange
0.59	GO:0021587	cerebellum morphogenesis

0.72	GO:0003684	damaged DNA binding
0.62	GO:1990599	3' overhang single-stranded DNA endodeoxyribonuclease activity
0.51	GO:0019899	enzyme binding
0.35	GO:0003909	DNA ligase activity

0.61	GO:0070522	ERCC4-ERCC1 complex
0.56	GO:0000784	nuclear chromosome, telomeric region
0.53	GO:0000790	nuclear chromatin
0.52	GO:0005730	nucleolus
0.35	GO:0005654	nucleoplasm
0.33	GO:0005739	mitochondrion

0.35

EC:6.5.1

GO:0003909

sp|P19012|K1C15_HUMAN
Keratin, type I cytoskeletal 15
Search

0.90	Putative nuclear envelope protein lamin intermediate filament superfamily

0.50	GO:0007010	cytoskeleton organization
0.44	GO:0042633	hair cycle
0.44	GO:0048513	animal organ development
0.43	GO:0030154	cell differentiation
0.43	GO:0009653	anatomical structure morphogenesis
0.43	GO:0045103	intermediate filament-based process
0.43	GO:0051546	keratinocyte migration
0.42	GO:0007568	aging
0.42	GO:0030336	negative regulation of cell migration
0.42	GO:0008544	epidermis development

0.62	GO:0005198	structural molecule activity
0.52	GO:0097110	scaffold protein binding
0.35	GO:1990254	keratin filament binding

0.79	GO:0005882	intermediate filament
0.43	GO:0043034	costamere
0.42	GO:1990357	terminal web
0.42	GO:0016327	apicolateral plasma membrane
0.41	GO:0042383	sarcolemma
0.41	GO:0030018	Z disc
0.41	GO:0070062	extracellular exosome
0.36	GO:0005634	nucleus
0.36	GO:0005829	cytosol
0.34	GO:0045178	basal part of cell

sp|P19013|K2C4_HUMAN
Keratin, type II cytoskeletal 4
Search

0.88	Keratin, type II cytoskeletal 2 oral

0.53	GO:0009888	tissue development
0.52	GO:0050680	negative regulation of epithelial cell proliferation
0.51	GO:0007010	cytoskeleton organization
0.48	GO:0030154	cell differentiation
0.48	GO:0043588	skin development
0.47	GO:0045103	intermediate filament-based process
0.42	GO:0022405	hair cycle process
0.42	GO:0043473	pigmentation
0.41	GO:0048732	gland development
0.40	GO:0097435	supramolecular fiber organization

0.62	GO:0005198	structural molecule activity
0.42	GO:0097110	scaffold protein binding
0.34	GO:0046982	protein heterodimerization activity
0.33	GO:0030246	carbohydrate binding

0.83	GO:0045095	keratin filament
0.49	GO:0009986	cell surface
0.37	GO:0070062	extracellular exosome
0.37	GO:0043231	intracellular membrane-bounded organelle
0.37	GO:0005829	cytosol
0.36	GO:0005886	plasma membrane

sp|P19021|AMD_HUMAN
Peptidyl-glycine alpha-amidating monooxygenase
Search

PAM

0.93	Peptidyl-glycine alpha-amidating monooxygenase

0.64	GO:0001519	peptide amidation
0.52	GO:0055114	oxidation-reduction process
0.42	GO:0018032	protein amidation
0.40	GO:0007595	lactation
0.40	GO:0060135	maternal process involved in female pregnancy
0.40	GO:0032355	response to estradiol
0.40	GO:0051384	response to glucocorticoid
0.40	GO:0042476	odontogenesis
0.40	GO:0022602	ovulation cycle process
0.39	GO:0009268	response to pH

0.82	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
0.69	GO:0005507	copper ion binding
0.64	GO:0004598	peptidylamidoglycolate lyase activity
0.47	GO:0008270	zinc ion binding
0.40	GO:0031418	L-ascorbic acid binding
0.38	GO:0019901	protein kinase binding
0.37	GO:0005509	calcium ion binding
0.32	GO:0003682	chromatin binding

0.41	GO:0030659	cytoplasmic vesicle membrane
0.40	GO:0043204	perikaryon
0.40	GO:0098805	whole membrane
0.39	GO:0098588	bounding membrane of organelle
0.39	GO:0030141	secretory granule
0.39	GO:0005802	trans-Golgi network
0.39	GO:0030133	transport vesicle
0.39	GO:0048471	perinuclear region of cytoplasm
0.38	GO:0043005	neuron projection
0.38	GO:0009986	cell surface

0.82

EC:1.14.17

GO:0016715

sp|P19022|CADH2_HUMAN
Cadherin-2
Search

CDH2

0.92	Cadherin 2, type 1 preproprotein (Predicted)

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.70	GO:0009966	regulation of signal transduction
0.60	GO:0044331	cell-cell adhesion mediated by cadherin
0.58	GO:1902897	regulation of postsynaptic density protein 95 clustering
0.58	GO:0097150	neuronal stem cell population maintenance
0.58	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly
0.57	GO:2000809	positive regulation of synaptic vesicle clustering
0.57	GO:0070445	regulation of oligodendrocyte progenitor proliferation
0.57	GO:0060019	radial glial cell differentiation
0.56	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

0.70	GO:0005509	calcium ion binding
0.56	GO:0045295	gamma-catenin binding
0.56	GO:0045294	alpha-catenin binding
0.54	GO:0019903	protein phosphatase binding
0.53	GO:0008013	beta-catenin binding
0.51	GO:0019901	protein kinase binding
0.49	GO:0042802	identical protein binding
0.35	GO:0050998	nitric-oxide synthase binding
0.35	GO:0050840	extracellular matrix binding
0.34	GO:0045296	cadherin binding

0.58	GO:0014704	intercalated disc
0.56	GO:0005886	plasma membrane
0.54	GO:0005913	cell-cell adherens junction
0.54	GO:0014069	postsynaptic density
0.54	GO:0030027	lamellipodium
0.52	GO:0098857	membrane microdomain
0.52	GO:0045177	apical part of cell
0.52	GO:0030864	cortical actin cytoskeleton
0.51	GO:0009986	cell surface
0.50	GO:0019898	extrinsic component of membrane

sp|P19075|TSN8_HUMAN
Tetraspanin-8
Search

TSPAN8

0.56	Tetraspanin

0.53	GO:0007283	spermatogenesis
0.44	GO:0007166	cell surface receptor signaling pathway
0.42	GO:0060255	regulation of macromolecule metabolic process
0.39	GO:0030195	negative regulation of blood coagulation
0.39	GO:0048916	posterior lateral line development

0.39

GO:0005178

integrin binding

0.51	GO:0009986	cell surface
0.42	GO:0005887	integral component of plasma membrane
0.37	GO:0070062	extracellular exosome

sp|P19086|GNAZ_HUMAN
Guanine nucleotide-binding protein G(z) subunit alpha
Search

GNAZ

0.84	G protein subunit alpha z

0.74	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
0.34	GO:0006457	protein folding
0.32	GO:0055085	transmembrane transport

0.76	GO:0031683	G-protein beta/gamma-subunit complex binding
0.64	GO:0003924	GTPase activity
0.62	GO:0032550	purine ribonucleoside binding
0.62	GO:0019001	guanyl nucleotide binding
0.61	GO:0004871	signal transducer activity
0.52	GO:0032555	purine ribonucleotide binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0001664	G-protein coupled receptor binding
0.34	GO:0046872	metal ion binding
0.32	GO:0022857	transmembrane transporter activity

0.50	GO:0030425	dendrite
0.50	GO:0044297	cell body
0.46	GO:1905360	GTPase complex
0.45	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.41	GO:0098797	plasma membrane protein complex
0.37	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome
0.34	GO:0005635	nuclear envelope
0.34	GO:0005783	endoplasmic reticulum

sp|P19087|GNAT2_HUMAN
Guanine nucleotide-binding protein G(t) subunit alpha-2
Search

GNAT2

0.94	Guanine nucleotide binding protein alpha transducing activity polypeptide 2

0.82	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
0.63	GO:0050908	detection of light stimulus involved in visual perception
0.59	GO:0042462	eye photoreceptor cell development
0.59	GO:0050913	sensory perception of bitter taste
0.58	GO:0042670	retinal cone cell differentiation
0.58	GO:0050917	sensory perception of umami taste
0.56	GO:0007602	phototransduction
0.53	GO:0050912	detection of chemical stimulus involved in sensory perception of taste
0.52	GO:0050916	sensory perception of sweet taste
0.45	GO:0071257	cellular response to electrical stimulus

0.81	GO:0031683	G-protein beta/gamma-subunit complex binding
0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.64	GO:0004871	signal transducer activity
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0001664	G-protein coupled receptor binding
0.37	GO:0000035	acyl binding
0.35	GO:0046872	metal ion binding

0.63	GO:0001917	photoreceptor inner segment
0.62	GO:0001750	photoreceptor outer segment
0.51	GO:1905360	GTPase complex
0.51	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.45	GO:0043234	protein complex
0.44	GO:0032391	photoreceptor connecting cilium
0.41	GO:0098590	plasma membrane region
0.40	GO:0045177	apical part of cell
0.38	GO:0030141	secretory granule
0.38	GO:0097223	sperm part

sp|P19099|C11B2_HUMAN
Cytochrome P450 11B2, mitochondrial
Search

0.80	Cholesterol side-chain cleavage enzyme, mitochondrial

0.67	GO:0006700	C21-steroid hormone biosynthetic process
0.61	GO:0032341	aldosterone metabolic process
0.61	GO:0006705	mineralocorticoid biosynthetic process
0.61	GO:0034650	cortisol metabolic process
0.55	GO:0006704	glucocorticoid biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.52	GO:0046184	aldehyde biosynthetic process
0.51	GO:0002017	regulation of blood volume by renal aldosterone
0.51	GO:1901617	organic hydroxy compound biosynthetic process
0.50	GO:0042181	ketone biosynthetic process

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.67	GO:0008395	steroid hydroxylase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.35	GO:0005496	steroid binding

0.54	GO:0005739	mitochondrion
0.46	GO:0031967	organelle envelope
0.46	GO:0031090	organelle membrane
0.35	GO:0030425	dendrite
0.35	GO:0030176	integral component of endoplasmic reticulum membrane

0.68

EC:1.14

GO:0016705

sp|P19105|ML12A_HUMAN
Myosin regulatory light chain 12A
Search

0.90	Myosin regulatory light chain

0.48	GO:0008360	regulation of cell shape
0.45	GO:0072659	protein localization to plasma membrane
0.36	GO:0006936	muscle contraction
0.35	GO:0070527	platelet aggregation
0.35	GO:0048013	ephrin receptor signaling pathway
0.34	GO:0031032	actomyosin structure organization

0.68	GO:0005509	calcium ion binding
0.52	GO:0032036	myosin heavy chain binding
0.46	GO:0035254	glutamate receptor binding
0.35	GO:0030898	actin-dependent ATPase activity
0.34	GO:0051015	actin filament binding
0.34	GO:0051020	GTPase binding
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.56	GO:0016460	myosin II complex
0.55	GO:0097517	contractile actin filament bundle
0.55	GO:0042641	actomyosin
0.54	GO:0030018	Z disc
0.50	GO:0005903	brush border
0.50	GO:0099738	cell cortex region
0.48	GO:0045177	apical part of cell
0.37	GO:0070062	extracellular exosome
0.35	GO:0097513	myosin II filament
0.34	GO:0005829	cytosol

sp|P19113|DCHS_HUMAN
Histidine decarboxylase
Search

HDC

0.80	Histidine decarboxylase

0.60	GO:0001694	histamine biosynthetic process
0.60	GO:0006520	cellular amino acid metabolic process
0.52	GO:0052805	imidazole-containing compound catabolic process
0.48	GO:0046395	carboxylic acid catabolic process
0.42	GO:0009628	response to abiotic stimulus
0.42	GO:0042330	taxis
0.42	GO:0007409	axonogenesis
0.41	GO:0007420	brain development
0.41	GO:0007268	chemical synaptic transmission
0.41	GO:0042423	catecholamine biosynthetic process

0.68	GO:0016831	carboxy-lyase activity
0.67	GO:0030170	pyridoxal phosphate binding
0.34	GO:0005515	protein binding
0.34	GO:0016597	amino acid binding
0.32	GO:0016874	ligase activity

0.35	GO:0005829	cytosol
0.35	GO:0043025	neuronal cell body
0.35	GO:0030425	dendrite

0.68

EC:4.1.1

GO:0016831

sp|P19174|PLCG1_HUMAN
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Search

PLCG1

0.52	Phosphoinositide phospholipase C

0.76	GO:0009395	phospholipid catabolic process
0.63	GO:0035556	intracellular signal transduction
0.56	GO:1901342	regulation of vasculature development
0.55	GO:0071364	cellular response to epidermal growth factor stimulus
0.55	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
0.55	GO:0030334	regulation of cell migration
0.54	GO:0050852	T cell receptor signaling pathway
0.54	GO:0007173	epidermal growth factor receptor signaling pathway
0.52	GO:2000147	positive regulation of cell motility
0.50	GO:0016477	cell migration

0.82	GO:0004435	phosphatidylinositol phospholipase C activity
0.63	GO:0004871	signal transducer activity
0.63	GO:0005509	calcium ion binding
0.57	GO:0005168	neurotrophin TRKA receptor binding
0.55	GO:0035254	glutamate receptor binding
0.54	GO:0030971	receptor tyrosine kinase binding

0.53	GO:0001726	ruffle
0.52	GO:0030027	lamellipodium
0.52	GO:0008180	COP9 signalosome
0.50	GO:0005911	cell-cell junction
0.46	GO:0005829	cytosol
0.41	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.82	EC:3.1.4.11	GO:0004435
0.82	KEGG:R03435	GO:0004435

sp|P19224|UD16_HUMAN
UDP-glucuronosyltransferase 1-6
Search

0.54	UDP-glucuronosyltransferase

0.61	GO:0052695	cellular glucuronidation
0.56	GO:0009812	flavonoid metabolic process
0.52	GO:0006805	xenobiotic metabolic process
0.48	GO:2001030	negative regulation of cellular glucuronidation
0.46	GO:1904223	regulation of glucuronosyltransferase activity
0.44	GO:0043086	negative regulation of catalytic activity
0.43	GO:0045922	negative regulation of fatty acid metabolic process
0.42	GO:0001889	liver development
0.41	GO:0042440	pigment metabolic process
0.41	GO:0071385	cellular response to glucocorticoid stimulus

0.82	GO:0015020	glucuronosyltransferase activity
0.50	GO:0042803	protein homodimerization activity
0.50	GO:0001972	retinoic acid binding
0.50	GO:0046982	protein heterodimerization activity
0.46	GO:0019899	enzyme binding
0.44	GO:0005496	steroid binding
0.43	GO:0004857	enzyme inhibitor activity
0.40	GO:0005504	fatty acid binding
0.35	GO:0008144	drug binding
0.34	GO:0032403	protein complex binding

0.50	GO:0005783	endoplasmic reticulum
0.45	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.43	GO:0031984	organelle subcompartment
0.39	GO:0005887	integral component of plasma membrane
0.38	GO:0070062	extracellular exosome
0.37	GO:0043234	protein complex
0.33	GO:0031966	mitochondrial membrane
0.33	GO:0019866	organelle inner membrane

0.82

GO:0015020

sp|P19235|EPOR_HUMAN
Erythropoietin receptor
Search

EPOR

0.96	Erythropoietin receptor

0.77	GO:0019221	cytokine-mediated signaling pathway
0.72	GO:0036018	cellular response to erythropoietin
0.70	GO:0046697	decidualization
0.63	GO:0007507	heart development
0.63	GO:0007420	brain development
0.39	GO:1904374	cellular response to kainic acid
0.38	GO:0030154	cell differentiation
0.38	GO:0045019	negative regulation of nitric oxide biosynthetic process
0.38	GO:1903206	negative regulation of hydrogen peroxide-induced cell death
0.37	GO:0060415	muscle tissue morphogenesis

0.79	GO:0004896	cytokine receptor activity
0.59	GO:0042802	identical protein binding
0.36	GO:0005085	guanyl-nucleotide exchange factor activity

0.37	GO:0005576	extracellular region
0.37	GO:0009897	external side of plasma membrane
0.35	GO:0005887	integral component of plasma membrane
0.33	GO:0005622	intracellular
0.32	GO:0012505	endomembrane system
0.32	GO:0043227	membrane-bounded organelle

sp|P19237|TNNI1_HUMAN
Troponin I, slow skeletal muscle
Search

TNNI1

0.92	Slow skeletal troponin I

0.55	GO:0014883	transition between fast and slow fiber
0.53	GO:0055010	ventricular cardiac muscle tissue morphogenesis
0.47	GO:0003009	skeletal muscle contraction
0.46	GO:0060048	cardiac muscle contraction
0.36	GO:0006937	regulation of muscle contraction
0.36	GO:0030049	muscle filament sliding
0.35	GO:1901876	regulation of calcium ion binding

0.37	GO:0003779	actin binding
0.34	GO:0046872	metal ion binding

0.83	GO:0005861	troponin complex
0.34	GO:0005829	cytosol

sp|P19256|LFA3_HUMAN
Lymphocyte function-associated antigen 3
Search

CD58

0.76	Lymphocyte function-associated antigen 3

0.58	GO:2000484	positive regulation of interleukin-8 secretion
0.58	GO:0043312	neutrophil degranulation
0.58	GO:0034113	heterotypic cell-cell adhesion
0.56	GO:0071346	cellular response to interferon-gamma
0.55	GO:0071356	cellular response to tumor necrosis factor
0.55	GO:0050900	leukocyte migration

0.50

GO:0005102

receptor binding

0.60	GO:0101003	ficolin-1-rich granule membrane
0.54	GO:0070062	extracellular exosome
0.53	GO:0031225	anchored component of membrane
0.51	GO:0009986	cell surface
0.47	GO:0005887	integral component of plasma membrane

sp|P19320|VCAM1_HUMAN
Vascular cell adhesion protein 1
Search

0.10	Vascular cell adhesion protein 1

0.75	GO:0098609	cell-cell adhesion
0.49	GO:0022614	membrane to membrane docking
0.48	GO:0045123	cellular extravasation
0.48	GO:0035584	calcium-mediated signaling using intracellular calcium source
0.47	GO:0042102	positive regulation of T cell proliferation
0.46	GO:0097151	positive regulation of inhibitory postsynaptic potential
0.46	GO:0007160	cell-matrix adhesion
0.42	GO:0009308	amine metabolic process
0.40	GO:0007186	G-protein coupled receptor signaling pathway
0.37	GO:0055114	oxidation-reduction process

0.47	GO:0005178	integrin binding
0.46	GO:0008131	primary amine oxidase activity
0.42	GO:0019900	kinase binding
0.41	GO:0004930	G-protein coupled receptor activity
0.35	GO:0004672	protein kinase activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.50	GO:0071065	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
0.48	GO:0002102	podosome
0.47	GO:0120025	plasma membrane bounded cell projection
0.46	GO:0009897	external side of plasma membrane
0.45	GO:0045177	apical part of cell
0.45	GO:0005769	early endosome
0.45	GO:0060077	inhibitory synapse
0.43	GO:0005615	extracellular space
0.43	GO:0043025	neuronal cell body
0.43	GO:0005794	Golgi apparatus

0.46	EC:1.4.3.21	GO:0008131
0.46	KEGG:R01853	GO:0008131

sp|P19338|NUCL_HUMAN
Nucleolin
Search

NCL

0.86

Nucleolin

0.58	GO:0071364	cellular response to epidermal growth factor stimulus
0.58	GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
0.57	GO:1990830	cellular response to leukemia inhibitory factor
0.54	GO:0001525	angiogenesis
0.52	GO:0045944	positive regulation of transcription by RNA polymerase II
0.52	GO:0017148	negative regulation of translation
0.38	GO:0009303	rRNA transcription
0.38	GO:0001947	heart looping
0.37	GO:0097421	liver regeneration
0.36	GO:2000778	positive regulation of interleukin-6 secretion

0.59	GO:0044547	DNA topoisomerase binding
0.59	GO:0003723	RNA binding
0.56	GO:0042162	telomeric DNA binding
0.55	GO:0008022	protein C-terminus binding
0.50	GO:0042802	identical protein binding
0.38	GO:1990631	ErbB-4 class receptor binding
0.36	GO:0043236	laminin binding
0.35	GO:0042393	histone binding
0.35	GO:0003697	single-stranded DNA binding
0.34	GO:0005509	calcium ion binding

0.53	GO:0036464	cytoplasmic ribonucleoprotein granule
0.53	GO:0005730	nucleolus
0.51	GO:0005938	cell cortex
0.49	GO:0005654	nucleoplasm
0.38	GO:0070062	extracellular exosome
0.35	GO:0009986	cell surface
0.31	GO:0005840	ribosome
0.30	GO:0016020	membrane

0.32	EC:2.8.3.16	GO:0033608
0.32	KEGG:R07290	GO:0033608

sp|P19367|HXK1_HUMAN
Hexokinase-1
Search

HK1

0.38	Phosphotransferase

0.82	GO:0001678	cellular glucose homeostasis
0.74	GO:0046835	carbohydrate phosphorylation
0.71	GO:0006757	ATP generation from ADP
0.69	GO:0006090	pyruvate metabolic process
0.68	GO:0016052	carbohydrate catabolic process
0.67	GO:0019362	pyridine nucleotide metabolic process
0.64	GO:0072656	maintenance of protein location in mitochondrion
0.64	GO:0002741	positive regulation of cytokine secretion involved in immune response
0.63	GO:0050718	positive regulation of interleukin-1 beta secretion
0.57	GO:0072655	establishment of protein localization to mitochondrion

0.83	GO:0005536	glucose binding
0.79	GO:0004396	hexokinase activity
0.56	GO:0042834	peptidoglycan binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0042803	protein homodimerization activity
0.43	GO:0032403	protein complex binding
0.40	GO:0004672	protein kinase activity
0.39	GO:0016887	ATPase activity

0.62	GO:0097228	sperm principal piece
0.58	GO:0045121	membrane raft
0.51	GO:0005829	cytosol
0.47	GO:0005739	mitochondrion
0.44	GO:0031968	organelle outer membrane
0.44	GO:0098590	plasma membrane region
0.39	GO:0043234	protein complex

0.79

EC:2.7.1.1

GO:0004396

sp|P19387|RPB3_HUMAN
DNA-directed RNA polymerase II subunit RPB3
Search

POLR2C

0.86	RNA polymerase II subunit C

0.56	GO:0006351	transcription, DNA-templated
0.37	GO:0006744	ubiquinone biosynthetic process
0.35	GO:0035019	somatic stem cell population maintenance
0.35	GO:0060964	regulation of gene silencing by miRNA
0.35	GO:0008543	fibroblast growth factor receptor signaling pathway
0.35	GO:0016073	snRNA metabolic process
0.35	GO:0050434	positive regulation of viral transcription
0.35	GO:0006283	transcription-coupled nucleotide-excision repair
0.34	GO:0000398	mRNA splicing, via spliceosome
0.34	GO:0006370	7-methylguanosine mRNA capping

0.67	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.66	GO:0046983	protein dimerization activity
0.49	GO:0003677	DNA binding

0.54	GO:0005665	DNA-directed RNA polymerase II, core complex
0.48	GO:0015630	microtubule cytoskeleton
0.47	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.67

GO:0003899

sp|P19388|RPAB1_HUMAN
DNA-directed RNA polymerases I, II, and III subunit RPABC1
Search

POLR2E

0.89	NA directed RNA polymerase II polypeptide E

0.58	GO:0006351	transcription, DNA-templated
0.35	GO:0035019	somatic stem cell population maintenance
0.35	GO:0032481	positive regulation of type I interferon production
0.35	GO:0060964	regulation of gene silencing by miRNA
0.35	GO:0045815	positive regulation of gene expression, epigenetic
0.35	GO:0008543	fibroblast growth factor receptor signaling pathway
0.34	GO:0016073	snRNA metabolic process
0.34	GO:0050434	positive regulation of viral transcription
0.34	GO:0006283	transcription-coupled nucleotide-excision repair
0.34	GO:0000398	mRNA splicing, via spliceosome

0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.55	GO:0003677	DNA binding
0.34	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.52	GO:0000428	DNA-directed RNA polymerase complex
0.49	GO:0031974	membrane-enclosed lumen
0.44	GO:0044446	intracellular organelle part
0.40	GO:0043232	intracellular non-membrane-bounded organelle
0.34	GO:1905369	endopeptidase complex
0.33	GO:0005829	cytosol
0.33	GO:0043234	protein complex

0.70

GO:0003899

sp|P19397|CD53_HUMAN
Leukocyte surface antigen CD53
Search

CD53

0.55	Tetraspanin

0.60	GO:1901741	positive regulation of myoblast fusion
0.46	GO:0007166	cell surface receptor signaling pathway
0.38	GO:0006461	protein complex assembly
0.38	GO:0045661	regulation of myoblast differentiation
0.37	GO:0098609	cell-cell adhesion
0.36	GO:0043312	neutrophil degranulation
0.35	GO:0040008	regulation of growth

0.41	GO:0003823	antigen binding
0.41	GO:0005178	integrin binding

0.60	GO:0001772	immunological synapse
0.54	GO:0005911	cell-cell junction
0.45	GO:0005887	integral component of plasma membrane
0.41	GO:0097197	tetraspanin-enriched microdomain
0.40	GO:0031982	vesicle
0.39	GO:0009986	cell surface
0.37	GO:0043230	extracellular organelle
0.36	GO:0005615	extracellular space
0.35	GO:0098805	whole membrane
0.34	GO:0098588	bounding membrane of organelle

sp|P19404|NDUV2_HUMAN
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Search

NDUFV2

0.89	NADH:ubiquinone oxidoreductase core subunit V2

0.76	GO:0048738	cardiac muscle tissue development
0.70	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
0.68	GO:0007399	nervous system development

0.70	GO:0051537	2 iron, 2 sulfur cluster binding
0.65	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.54	GO:0046872	metal ion binding

0.76	GO:0005747	mitochondrial respiratory chain complex I
0.59	GO:0045272	plasma membrane respiratory chain complex I
0.57	GO:0043209	myelin sheath

0.65

EC:1.6.5.3

GO:0008137

sp|P19419|ELK1_HUMAN
ETS domain-containing protein Elk-1
Search

ELK1

0.85	ETS domain-containing protein Elk-1

0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:0010468	regulation of gene expression
0.54	GO:0006366	transcription by RNA polymerase II
0.54	GO:1902680	positive regulation of RNA biosynthetic process
0.45	GO:0030154	cell differentiation
0.44	GO:0071394	cellular response to testosterone stimulus
0.44	GO:0071480	cellular response to gamma radiation
0.43	GO:1901216	positive regulation of neuron death
0.42	GO:0071774	response to fibroblast growth factor

0.64	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.58	GO:0001085	RNA polymerase II transcription factor binding
0.56	GO:0001012	RNA polymerase II regulatory region DNA binding
0.53	GO:0003690	double-stranded DNA binding
0.41	GO:0003682	chromatin binding
0.36	GO:0001106	RNA polymerase II transcription corepressor activity

0.61	GO:0005634	nucleus
0.50	GO:0031974	membrane-enclosed lumen
0.45	GO:0044446	intracellular organelle part
0.43	GO:0043679	axon terminus
0.42	GO:0043025	neuronal cell body
0.42	GO:0030425	dendrite
0.37	GO:0005739	mitochondrion
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|P19429|TNNI3_HUMAN
Troponin I, cardiac muscle
Search

TNNI3

0.89	High Mr cardiac troponin I

0.59	GO:0001980	regulation of systemic arterial blood pressure by ischemic conditions
0.59	GO:0006941	striated muscle contraction
0.58	GO:0060047	heart contraction
0.57	GO:0055010	ventricular cardiac muscle tissue morphogenesis
0.56	GO:0090257	regulation of muscle system process
0.55	GO:0001570	vasculogenesis
0.53	GO:0019722	calcium-mediated signaling
0.53	GO:0008016	regulation of heart contraction
0.52	GO:0006874	cellular calcium ion homeostasis
0.52	GO:0032780	negative regulation of ATPase activity

0.58	GO:0031014	troponin T binding
0.57	GO:0030172	troponin C binding
0.56	GO:0019855	calcium channel inhibitor activity
0.54	GO:0048306	calcium-dependent protein binding
0.51	GO:0003779	actin binding
0.51	GO:0019901	protein kinase binding
0.50	GO:0019904	protein domain specific binding
0.49	GO:0032403	protein complex binding
0.38	GO:0046872	metal ion binding
0.33	GO:0016887	ATPase activity

0.82	GO:0005861	troponin complex
0.56	GO:0097512	cardiac myofibril
0.34	GO:0005829	cytosol
0.33	GO:0005634	nucleus

0.33

GO:0016887

sp|P19438|TNR1A_HUMAN
Tumor necrosis factor receptor superfamily member 1A
Search

TNFRSF1A

0.95	Tumor necrosis factor type I

0.83	GO:0006692	prostanoid metabolic process
0.83	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.77	GO:0006954	inflammatory response
0.66	GO:1903140	regulation of establishment of endothelial barrier
0.64	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
0.64	GO:0071260	cellular response to mechanical stimulus
0.63	GO:0097190	apoptotic signaling pathway
0.63	GO:0050728	negative regulation of inflammatory response
0.63	GO:0050729	positive regulation of inflammatory response
0.62	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling

0.85	GO:0005031	tumor necrosis factor-activated receptor activity
0.55	GO:0043120	tumor necrosis factor binding
0.39	GO:0042802	identical protein binding
0.38	GO:0005272	sodium channel activity
0.36	GO:0002020	protease binding
0.36	GO:0099094	ligand-gated cation channel activity
0.35	GO:0032403	protein complex binding
0.34	GO:0046872	metal ion binding
0.32	GO:0004672	protein kinase activity
0.31	GO:0030554	adenyl nucleotide binding

0.60	GO:0098857	membrane microdomain
0.59	GO:0043235	receptor complex
0.57	GO:0000139	Golgi membrane
0.57	GO:0009986	cell surface
0.56	GO:0005615	extracellular space
0.45	GO:0005887	integral component of plasma membrane
0.42	GO:0005739	mitochondrion
0.36	GO:0030424	axon
0.35	GO:0045202	synapse
0.35	GO:0005829	cytosol

sp|P19440|GGT1_HUMAN
Gamma-glutamyltranspeptidase 1
Search

GGT1

0.70	Glutathione hydrolase 1 proenzyme

0.79	GO:0006751	glutathione catabolic process
0.61	GO:0006508	proteolysis
0.50	GO:0050727	regulation of inflammatory response
0.50	GO:0006750	glutathione biosynthetic process
0.49	GO:0007283	spermatogenesis
0.47	GO:0019344	cysteine biosynthetic process
0.46	GO:0002682	regulation of immune system process
0.45	GO:1901748	leukotriene D4 metabolic process
0.43	GO:0019370	leukotriene biosynthetic process
0.38	GO:0051604	protein maturation

0.80	GO:0036374	glutathione hydrolase activity
0.41	GO:0103068	leukotriene C4 gamma-glutamyl transferase activity
0.41	GO:0102953	hypoglycin A gamma-glutamyl transpeptidase activity
0.40	GO:0002951	leukotriene-C(4) hydrolase
0.40	GO:0000048	peptidyltransferase activity
0.33	GO:0005515	protein binding

0.47	GO:0031982	vesicle
0.40	GO:0043230	extracellular organelle
0.39	GO:0005615	extracellular space
0.35	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0005886	plasma membrane
0.34	GO:0005783	endoplasmic reticulum
0.30	GO:0016021	integral component of membrane

0.80	EC:3.4.19.13	GO:0036374
0.80	KEGG:R00494	GO:0036374

sp|P19447|ERCC3_HUMAN
TFIIH basal transcription factor complex helicase XPB subunit
Search

ERCC3

0.89	General transcription and DNA repair factor IIH helicase subunit XPB

0.76	GO:0006367	transcription initiation from RNA polymerase II promoter
0.70	GO:0006289	nucleotide-excision repair
0.68	GO:0032392	DNA geometric change
0.59	GO:0009650	UV protection
0.59	GO:0035315	hair cell differentiation
0.55	GO:0006915	apoptotic process
0.55	GO:1901990	regulation of mitotic cell cycle phase transition
0.54	GO:0043065	positive regulation of apoptotic process
0.53	GO:0045944	positive regulation of transcription by RNA polymerase II
0.52	GO:0006265	DNA topological change

0.69	GO:0004003	ATP-dependent DNA helicase activity
0.59	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.59	GO:0047485	protein N-terminus binding
0.57	GO:0008022	protein C-terminus binding
0.56	GO:0043138	3'-5' DNA helicase activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0003677	DNA binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0008134	transcription factor binding

0.58	GO:0005675	holo TFIIH complex
0.55	GO:0005669	transcription factor TFIID complex
0.38	GO:0000439	core TFIIH complex
0.34	GO:0005576	extracellular region
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.59

EC:2.7.11.23

GO:0008353

sp|P19474|RO52_HUMAN
E3 ubiquitin-protein ligase TRIM21
Search

0.51	Tripartite motif-containing protein 6

0.61	GO:0046598	positive regulation of viral entry into host cell
0.59	GO:1902187	negative regulation of viral release from host cell
0.59	GO:0032897	negative regulation of viral transcription
0.58	GO:0045087	innate immune response
0.57	GO:0090086	negative regulation of protein deubiquitination
0.57	GO:0016567	protein ubiquitination
0.54	GO:0051091	positive regulation of DNA binding transcription factor activity
0.54	GO:0031648	protein destabilization
0.54	GO:0032088	negative regulation of NF-kappaB transcription factor activity
0.53	GO:0070206	protein trimerization

0.61	GO:0008270	zinc ion binding
0.57	GO:0004842	ubiquitin-protein transferase activity
0.51	GO:0042802	identical protein binding
0.44	GO:0016874	ligase activity
0.43	GO:0061659	ubiquitin-like protein ligase activity
0.42	GO:0019904	protein domain specific binding
0.41	GO:0008134	transcription factor binding
0.40	GO:0038187	pattern recognition receptor activity
0.37	GO:0004871	signal transducer activity
0.35	GO:0003723	RNA binding

0.53	GO:0019005	SCF ubiquitin ligase complex
0.47	GO:0005654	nucleoplasm
0.44	GO:0005829	cytosol
0.42	GO:0000932	P-body
0.39	GO:0005776	autophagosome
0.37	GO:0031410	cytoplasmic vesicle
0.37	GO:0005739	mitochondrion
0.34	GO:0005886	plasma membrane
0.34	GO:1990462	omegasome
0.32	GO:0009986	cell surface

0.44	EC:6	GO:0016874
0.57	KEGG:R03876	GO:0004842

sp|P19484|TFEB_HUMAN
Transcription factor EB
Search

TFEB

0.97	Transcription factor EB

0.80	GO:0006959	humoral immune response
0.71	GO:0045893	positive regulation of transcription, DNA-templated
0.41	GO:0001892	embryonic placenta development
0.41	GO:1902477	regulation of defense response to bacterium, incompatible interaction
0.41	GO:0007040	lysosome organization
0.40	GO:0045670	regulation of osteoclast differentiation
0.40	GO:0010508	positive regulation of autophagy
0.39	GO:0050829	defense response to Gram-negative bacterium
0.39	GO:0006357	regulation of transcription by RNA polymerase II
0.38	GO:0006366	transcription by RNA polymerase II

0.67	GO:0046983	protein dimerization activity
0.39	GO:0044212	transcription regulatory region DNA binding
0.39	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.38	GO:1990837	sequence-specific double-stranded DNA binding

0.38	GO:0005667	transcription factor complex
0.38	GO:0005634	nucleus
0.36	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part
0.34	GO:0005737	cytoplasm

sp|P19525|E2AK2_HUMAN
Interferon-induced, double-stranded RNA-activated protein kinase
Search

EIF2AK2

0.93	Eukaryotic translation initiation factor 2-alpha kinase 2

0.85	GO:0045071	negative regulation of viral genome replication
0.85	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation
0.79	GO:0008285	negative regulation of cell proliferation
0.79	GO:0045087	innate immune response
0.77	GO:0009615	response to virus
0.74	GO:0042981	regulation of apoptotic process
0.67	GO:0009636	response to toxic substance
0.62	GO:0006413	translational initiation
0.62	GO:0035455	response to interferon-alpha
0.62	GO:0033688	regulation of osteoblast proliferation

0.76	GO:0003725	double-stranded RNA binding
0.70	GO:0004674	protein serine/threonine kinase activity
0.63	GO:0003743	translation initiation factor activity
0.59	GO:0045182	translation regulator activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0042802	identical protein binding
0.35	GO:0003726	double-stranded RNA adenosine deaminase activity

0.56	GO:0048471	perinuclear region of cytoplasm
0.51	GO:0005829	cytosol

0.70

GO:0004674

sp|P19526|FUT1_HUMAN
Galactoside 2-alpha-L-fucosyltransferase 1
Search

FUT1

0.83	L-Fucosyltransferase

0.81	GO:0036065	fucosylation
0.74	GO:0043413	macromolecule glycosylation
0.74	GO:0009101	glycoprotein biosynthetic process
0.60	GO:0005975	carbohydrate metabolic process
0.60	GO:0036211	protein modification process
0.55	GO:0044267	cellular protein metabolic process
0.34	GO:0044282	small molecule catabolic process
0.34	GO:1901575	organic substance catabolic process

0.84

GO:0008107

galactoside 2-alpha-L-fucosyltransferase activity

0.81	GO:0032580	Golgi cisterna membrane
0.35	GO:0070062	extracellular exosome
0.34	GO:0005887	integral component of plasma membrane

0.84

EC:2.4.1.69

GO:0008107

sp|P19532|TFE3_HUMAN
Transcription factor E3
Search

TFE3

0.86	Microphthalmia-associated transcription factor L homeolog type A transcript variant

0.80	GO:0045670	regulation of osteoclast differentiation
0.75	GO:0006959	humoral immune response
0.68	GO:0045893	positive regulation of transcription, DNA-templated
0.61	GO:0006357	regulation of transcription by RNA polymerase II
0.56	GO:0045785	positive regulation of cell adhesion
0.56	GO:0006366	transcription by RNA polymerase II
0.42	GO:0030318	melanocyte differentiation
0.40	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process
0.40	GO:0002250	adaptive immune response
0.39	GO:0030316	osteoclast differentiation

0.68	GO:0046983	protein dimerization activity
0.59	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.58	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.39	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.38	GO:0003682	chromatin binding
0.34	GO:0005249	voltage-gated potassium channel activity

0.54	GO:0005634	nucleus
0.51	GO:0005829	cytosol
0.51	GO:0031974	membrane-enclosed lumen
0.45	GO:0044446	intracellular organelle part
0.36	GO:0043234	protein complex
0.34	GO:0008076	voltage-gated potassium channel complex

sp|P19544|WT1_HUMAN
Wilms tumor protein
Search

WT1

0.97	Wilm's tumor suppressor-1

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.55	GO:0072112	glomerular visceral epithelial cell differentiation
0.52	GO:0061032	visceral serous pericardium development
0.50	GO:0030325	adrenal gland development
0.49	GO:0008285	negative regulation of cell proliferation
0.48	GO:0072284	metanephric S-shaped body morphogenesis
0.48	GO:0072299	negative regulation of metanephric glomerulus development
0.48	GO:2001076	positive regulation of metanephric ureteric bud development

0.50	GO:0044729	hemi-methylated DNA-binding
0.49	GO:0010385	double-stranded methylated DNA binding
0.44	GO:0070742	C2H2 zinc finger domain binding
0.43	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.43	GO:0044212	transcription regulatory region DNA binding
0.41	GO:0043565	sequence-specific DNA binding
0.40	GO:0008270	zinc ion binding
0.39	GO:0003723	RNA binding

0.60	GO:0005634	nucleus
0.51	GO:0070013	intracellular organelle lumen
0.50	GO:0005829	cytosol
0.46	GO:0044446	intracellular organelle part
0.36	GO:0043232	intracellular non-membrane-bounded organelle

sp|P19622|HME2_HUMAN
Homeobox protein engrailed-2
Search

0.83	Homeobox protein engrailed-2

0.69	GO:0007275	multicellular organism development
0.58	GO:0043524	negative regulation of neuron apoptotic process
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0060322	head development
0.56	GO:0010468	regulation of gene expression
0.54	GO:0048468	cell development
0.53	GO:1902680	positive regulation of RNA biosynthetic process
0.43	GO:0061743	motor learning
0.42	GO:0042756	drinking behavior

0.64	GO:0043565	sequence-specific DNA binding
0.40	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.39	GO:0001012	RNA polymerase II regulatory region DNA binding
0.38	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.48	GO:0031974	membrane-enclosed lumen
0.44	GO:0043232	intracellular non-membrane-bounded organelle
0.43	GO:0044446	intracellular organelle part
0.35	GO:0030175	filopodium
0.35	GO:0030426	growth cone
0.35	GO:0030027	lamellipodium
0.30	GO:0016020	membrane

sp|P19623|SPEE_HUMAN
Spermidine synthase
Search

SRM

0.51	Spermidine synthase

0.76	GO:0006596	polyamine biosynthetic process
0.55	GO:0008216	spermidine metabolic process
0.52	GO:1990830	cellular response to leukemia inhibitory factor
0.38	GO:0055114	oxidation-reduction process
0.38	GO:0001867	complement activation, lectin pathway
0.37	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.36	GO:0006396	RNA processing
0.35	GO:0010469	regulation of receptor activity
0.35	GO:0006468	protein phosphorylation
0.34	GO:0006508	proteolysis

0.54	GO:0004766	spermidine synthase activity
0.49	GO:0042803	protein homodimerization activity
0.39	GO:0016491	oxidoreductase activity
0.38	GO:0008408	3'-5' exonuclease activity
0.36	GO:0044877	macromolecular complex binding
0.36	GO:0004674	protein serine/threonine kinase activity
0.36	GO:0005509	calcium ion binding
0.35	GO:0004252	serine-type endopeptidase activity
0.35	GO:0005179	hormone activity
0.35	GO:1901265	nucleoside phosphate binding

0.40	GO:0000176	nuclear exosome (RNase complex)
0.34	GO:0005576	extracellular region
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.54

EC:2.5.1.16

GO:0004766

sp|P19634|SL9A1_HUMAN
Sodium/hydrogen exchanger 1
Search

SLC9A1

0.59	Sodium/hydrogen exchanger

0.79	GO:0006885	regulation of pH
0.77	GO:0035725	sodium ion transmembrane transport
0.63	GO:0086092	regulation of the force of heart contraction by cardiac conduction
0.63	GO:1903281	positive regulation of calcium:sodium antiporter activity
0.63	GO:1902600	hydrogen ion transmembrane transport
0.62	GO:0098735	positive regulation of the force of heart contraction
0.62	GO:0071872	cellular response to epinephrine stimulus
0.62	GO:0071468	cellular response to acidic pH
0.62	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade
0.61	GO:0006883	cellular sodium ion homeostasis

0.82	GO:0015385	sodium:proton antiporter activity
0.62	GO:0030346	protein phosphatase 2B binding
0.61	GO:0048306	calcium-dependent protein binding
0.47	GO:0015386	potassium:proton antiporter activity
0.42	GO:0005516	calmodulin binding
0.35	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.35	GO:0032947	protein complex scaffold activity
0.35	GO:0030674	protein binding, bridging

0.58	GO:0090533	cation-transporting ATPase complex
0.56	GO:0016324	apical plasma membrane
0.56	GO:0098857	membrane microdomain
0.51	GO:0005654	nucleoplasm
0.49	GO:0005887	integral component of plasma membrane
0.40	GO:0030315	T-tubule
0.40	GO:0005737	cytoplasm
0.40	GO:0014704	intercalated disc
0.40	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.39	GO:0016323	basolateral plasma membrane

sp|P19652|A1AG2_HUMAN
Alpha-1-acid glycoprotein 2
Search

0.97	Alpha-1-acid glycoprotein 2

0.71	GO:0002682	regulation of immune system process
0.57	GO:1904469	positive regulation of tumor necrosis factor secretion
0.56	GO:0050718	positive regulation of interleukin-1 beta secretion
0.52	GO:0032715	negative regulation of interleukin-6 production
0.52	GO:0032720	negative regulation of tumor necrosis factor production
0.50	GO:0006953	acute-phase response
0.44	GO:0002576	platelet degranulation
0.43	GO:0043312	neutrophil degranulation
0.37	GO:0002439	chronic inflammatory response to antigenic stimulus
0.37	GO:0033197	response to vitamin E

0.35	GO:0005515	protein binding
0.33	GO:0008144	drug binding

0.73	GO:0005615	extracellular space
0.49	GO:0031012	extracellular matrix
0.44	GO:0035580	specific granule lumen
0.44	GO:0031093	platelet alpha granule lumen
0.43	GO:1903561	extracellular vesicle
0.40	GO:0035578	azurophil granule lumen
0.40	GO:1904724	tertiary granule lumen
0.35	GO:0005581	collagen trimer
0.30	GO:0031224	intrinsic component of membrane

sp|P19784|CSK22_HUMAN
Casein kinase II subunit alpha'
Search

CSNK2A2

0.80	Casein kinase II subunit alpha'

0.63	GO:0006468	protein phosphorylation
0.56	GO:1903146	regulation of autophagy of mitochondrion
0.55	GO:1903955	positive regulation of protein targeting to mitochondrion
0.53	GO:1905818	regulation of chromosome separation
0.40	GO:0097421	liver regeneration
0.39	GO:0021987	cerebral cortex development
0.39	GO:0007276	gamete generation
0.38	GO:0007267	cell-cell signaling
0.37	GO:0007166	cell surface receptor signaling pathway
0.37	GO:0006915	apoptotic process

0.68	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0047485	protein N-terminus binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.54	GO:0031519	PcG protein complex
0.39	GO:0001669	acrosomal vesicle
0.37	GO:0000785	chromatin
0.36	GO:0005956	protein kinase CK2 complex
0.34	GO:0005829	cytosol
0.34	GO:0005886	plasma membrane
0.34	GO:0005654	nucleoplasm

0.68

GO:0004674

sp|P19793|RXRA_HUMAN
Retinoic acid receptor RXR-alpha
Search

RXRA

0.92	Retinoic acid receptor RXR-alpha

0.78	GO:0043401	steroid hormone mediated signaling pathway
0.58	GO:0097659	nucleic acid-templated transcription
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.54	GO:0010467	gene expression
0.52	GO:0034645	cellular macromolecule biosynthetic process
0.45	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
0.45	GO:0060687	regulation of branching involved in prostate gland morphogenesis
0.45	GO:0035357	peroxisome proliferator activated receptor signaling pathway

0.79	GO:0003707	steroid hormone receptor activity
0.64	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.45	GO:0050692	DBD domain binding
0.45	GO:0050693	LBD domain binding
0.45	GO:0042809	vitamin D receptor binding
0.44	GO:0001972	retinoic acid binding
0.44	GO:0016922	ligand-dependent nuclear receptor binding
0.43	GO:0031490	chromatin DNA binding

0.61	GO:0005634	nucleus
0.42	GO:0043235	receptor complex
0.41	GO:0005667	transcription factor complex
0.40	GO:0000785	chromatin
0.39	GO:0070013	intracellular organelle lumen
0.36	GO:0030424	axon

sp|P19801|AOC1_HUMAN
Amiloride-sensitive amine oxidase [copper-containing]
Search

AOC1

0.50	Amiloride-sensitive amine oxidase [copper-containing]

0.70	GO:0009308	amine metabolic process
0.62	GO:0097185	cellular response to azide
0.62	GO:0035874	cellular response to copper ion starvation
0.60	GO:0071420	cellular response to histamine
0.59	GO:0071280	cellular response to copper ion
0.53	GO:0055114	oxidation-reduction process
0.51	GO:0046677	response to antibiotic
0.49	GO:0042493	response to drug
0.48	GO:0007601	visual perception
0.37	GO:0043312	neutrophil degranulation

0.83	GO:0008131	primary amine oxidase activity
0.72	GO:0048038	quinone binding
0.72	GO:0005507	copper ion binding
0.62	GO:0052597	diamine oxidase activity
0.55	GO:0008201	heparin binding
0.52	GO:0032403	protein complex binding
0.49	GO:0042803	protein homodimerization activity
0.47	GO:0005509	calcium ion binding
0.47	GO:0004872	receptor activity
0.46	GO:0008270	zinc ion binding

0.51	GO:0070062	extracellular exosome
0.48	GO:0005923	bicellular tight junction
0.43	GO:0005886	plasma membrane
0.37	GO:0035580	specific granule lumen
0.35	GO:0005777	peroxisome
0.35	GO:0008537	proteasome activator complex
0.34	GO:0005902	microvillus
0.33	GO:0005769	early endosome
0.33	GO:0009986	cell surface
0.33	GO:0005794	Golgi apparatus

0.83	EC:1.4.3.21	GO:0008131
0.83	KEGG:R01853	GO:0008131

sp|P19823|ITIH2_HUMAN
Inter-alpha-trypsin inhibitor heavy chain H2
Search

ITIH2

0.97	Inter-alpha-trypsin inhibitor heavy chain 2

0.84	GO:0030212	hyaluronan metabolic process
0.74	GO:0010951	negative regulation of endopeptidase activity
0.36	GO:0043687	post-translational protein modification

0.77

GO:0004867

serine-type endopeptidase inhibitor activity

0.38	GO:0005576	extracellular region
0.36	GO:0031982	vesicle
0.36	GO:0005788	endoplasmic reticulum lumen

sp|P19827|ITIH1_HUMAN
Inter-alpha-trypsin inhibitor heavy chain H1
Search

ITIH1

0.95	Inter-alpha-trypsin inhibitor heavy chain 1

0.85	GO:0030212	hyaluronan metabolic process
0.76	GO:0010951	negative regulation of endopeptidase activity
0.35	GO:0002576	platelet degranulation
0.34	GO:0006953	acute-phase response
0.33	GO:0034097	response to cytokine

0.78	GO:0004867	serine-type endopeptidase inhibitor activity
0.35	GO:0005509	calcium ion binding

0.41	GO:0005576	extracellular region
0.38	GO:0031982	vesicle
0.33	GO:0012505	endomembrane system
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part
0.32	GO:0044444	cytoplasmic part

sp|P19835|CEL_HUMAN
Bile salt-activated lipase
Search

CEL

0.44	Carboxylic ester hydrolase

0.62	GO:0006629	lipid metabolic process
0.44	GO:1901565	organonitrogen compound catabolic process
0.43	GO:0044248	cellular catabolic process
0.41	GO:0043603	cellular amide metabolic process
0.37	GO:0030299	intestinal cholesterol absorption
0.36	GO:0006775	fat-soluble vitamin metabolic process
0.36	GO:0016049	cell growth
0.35	GO:1902652	secondary alcohol metabolic process
0.35	GO:0046164	alcohol catabolic process
0.35	GO:0030154	cell differentiation

0.61	GO:0016788	hydrolase activity, acting on ester bonds
0.34	GO:0005515	protein binding

0.35	GO:0005794	Golgi apparatus
0.35	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane

0.61

EC:3.1

GO:0016788

sp|P19838|NFKB1_HUMAN
Nuclear factor NF-kappa-B p105 subunit
Search

NFKB1

0.96	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

0.71	GO:0006357	regulation of transcription by RNA polymerase II
0.62	GO:0045083	negative regulation of interleukin-12 biosynthetic process
0.61	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity
0.61	GO:1900127	positive regulation of hyaluronan biosynthetic process
0.61	GO:0071316	cellular response to nicotine
0.61	GO:2000630	positive regulation of miRNA metabolic process
0.59	GO:0007165	signal transduction
0.59	GO:0071354	cellular response to interleukin-6
0.59	GO:0035994	response to muscle stretch
0.59	GO:1904385	cellular response to angiotensin

0.61	GO:0003700	DNA binding transcription factor activity
0.58	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.56	GO:0042805	actinin binding
0.54	GO:0003682	chromatin binding
0.52	GO:0042803	protein homodimerization activity
0.52	GO:0046982	protein heterodimerization activity
0.51	GO:0008134	transcription factor binding
0.33	GO:0031072	heat shock protein binding

0.61	GO:0005634	nucleus
0.50	GO:0005829	cytosol
0.49	GO:0070013	intracellular organelle lumen
0.48	GO:0033256	I-kappaB/NF-kappaB complex
0.45	GO:0005739	mitochondrion
0.44	GO:0044446	intracellular organelle part
0.36	GO:0042581	specific granule
0.36	GO:0031983	vesicle lumen
0.34	GO:0005576	extracellular region
0.33	GO:0043005	neuron projection

sp|P19875|CXCL2_HUMAN
C-X-C motif chemokine 2
Search

0.89	C-X-C motif chemokine

0.82	GO:0060326	cell chemotaxis
0.74	GO:0006955	immune response
0.73	GO:0010469	regulation of receptor activity
0.72	GO:0006952	defense response
0.53	GO:0090023	positive regulation of neutrophil chemotaxis
0.52	GO:0002237	response to molecule of bacterial origin
0.51	GO:0070098	chemokine-mediated signaling pathway
0.49	GO:0042127	regulation of cell proliferation
0.49	GO:0033993	response to lipid
0.47	GO:1901700	response to oxygen-containing compound

0.84	GO:0008009	chemokine activity
0.55	GO:0045236	CXCR chemokine receptor binding
0.42	GO:0008083	growth factor activity
0.36	GO:0008201	heparin binding
0.35	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity
0.34	GO:0008047	enzyme activator activity
0.33	GO:0042056	chemoattractant activity
0.32	GO:0016787	hydrolase activity

0.71	GO:0005615	extracellular space
0.36	GO:1904724	tertiary granule lumen
0.36	GO:0035580	specific granule lumen
0.30	GO:0016020	membrane

0.35	EC:1.5.1.5	GO:0004488
0.35	KEGG:R01220	GO:0004488

sp|P19876|CXCL3_HUMAN
C-X-C motif chemokine 3
Search

0.89	C-X-C motif chemokine

0.82	GO:0060326	cell chemotaxis
0.74	GO:0006955	immune response
0.73	GO:0010469	regulation of receptor activity
0.72	GO:0006952	defense response
0.53	GO:0090023	positive regulation of neutrophil chemotaxis
0.52	GO:0002237	response to molecule of bacterial origin
0.51	GO:0070098	chemokine-mediated signaling pathway
0.49	GO:0033993	response to lipid
0.49	GO:0042127	regulation of cell proliferation
0.47	GO:1901700	response to oxygen-containing compound

0.84	GO:0008009	chemokine activity
0.56	GO:0045236	CXCR chemokine receptor binding
0.42	GO:0008083	growth factor activity
0.36	GO:0008201	heparin binding
0.35	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity
0.34	GO:0008047	enzyme activator activity
0.33	GO:0042056	chemoattractant activity
0.32	GO:0016787	hydrolase activity

0.71	GO:0005615	extracellular space
0.36	GO:1904724	tertiary granule lumen
0.36	GO:0035580	specific granule lumen
0.30	GO:0016020	membrane

0.35	EC:1.5.1.5	GO:0004488
0.35	KEGG:R01220	GO:0004488

sp|P19878|NCF2_HUMAN
Neutrophil cytosol factor 2
Search

NCF2

0.95	Neutrophil cytosolic factor 2

0.86	GO:0045730	respiratory burst
0.83	GO:0006909	phagocytosis
0.73	GO:0043085	positive regulation of catalytic activity
0.59	GO:0042554	superoxide anion generation
0.41	GO:0055114	oxidation-reduction process
0.36	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.36	GO:0006968	cellular defense response
0.36	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.35	GO:0034616	response to laminar fluid shear stress
0.35	GO:0006742	NADP catabolic process

0.86	GO:0016176	superoxide-generating NADPH oxidase activator activity
0.59	GO:0016175	superoxide-generating NADPH oxidase activity
0.58	GO:0048365	Rac GTPase binding
0.56	GO:0008022	protein C-terminus binding
0.33	GO:0009055	electron transfer activity

0.85	GO:0043020	NADPH oxidase complex
0.57	GO:0001669	acrosomal vesicle
0.51	GO:0005730	nucleolus
0.49	GO:0005829	cytosol
0.36	GO:0032010	phagolysosome
0.34	GO:0005885	Arp2/3 protein complex

0.59

EC:1.6.3

GO:0016175

sp|P19883|FST_HUMAN
Follistatin
Search

FST

0.97	Follistatin

0.85	GO:0032926	negative regulation of activin receptor signaling pathway
0.84	GO:0051798	positive regulation of hair follicle development
0.80	GO:0002244	hematopoietic progenitor cell differentiation
0.73	GO:0000122	negative regulation of transcription by RNA polymerase II
0.44	GO:0043616	keratinocyte proliferation
0.43	GO:0045596	negative regulation of cell differentiation
0.43	GO:0031069	hair follicle morphogenesis
0.43	GO:0001501	skeletal system development
0.43	GO:0007389	pattern specification process
0.43	GO:0042475	odontogenesis of dentin-containing tooth

0.85	GO:0048185	activin binding
0.48	GO:0043395	heparan sulfate proteoglycan binding
0.36	GO:0016651	oxidoreductase activity, acting on NAD(P)H
0.36	GO:0004871	signal transducer activity

0.49	GO:0005576	extracellular region
0.37	GO:0005634	nucleus
0.34	GO:0005737	cytoplasm

0.36

EC:1.6

GO:0016651

sp|P19957|ELAF_HUMAN
Elafin
Search

PI3

0.97	Elastase-specific inhibitor

0.75	GO:0010466	negative regulation of peptidase activity
0.73	GO:0007620	copulation
0.63	GO:0018149	peptide cross-linking
0.41	GO:0052548	regulation of endopeptidase activity
0.40	GO:0019730	antimicrobial humoral response
0.40	GO:0070268	cornification
0.35	GO:0045071	negative regulation of viral genome replication
0.35	GO:0032091	negative regulation of protein binding
0.35	GO:0032496	response to lipopolysaccharide
0.35	GO:0045087	innate immune response

0.76	GO:0030414	peptidase inhibitor activity
0.67	GO:0030280	structural constituent of epidermis
0.41	GO:0061135	endopeptidase regulator activity
0.34	GO:0003729	mRNA binding
0.34	GO:0019899	enzyme binding
0.33	GO:0016301	kinase activity
0.33	GO:0003677	DNA binding

0.66	GO:0005576	extracellular region
0.64	GO:0001533	cornified envelope
0.37	GO:0031982	vesicle
0.37	GO:0005829	cytosol

sp|P19961|AMY2B_HUMAN
Alpha-amylase 2B
Search

0.43	Pancreatic alpha-amylase

0.60	GO:0005975	carbohydrate metabolic process
0.38	GO:0007586	digestion
0.36	GO:1901575	organic substance catabolic process

0.80	GO:0103025	alpha-amylase activity (releasing maltohexaose)
0.80	GO:0004556	alpha-amylase activity
0.53	GO:0043169	cation binding
0.41	GO:0031404	chloride ion binding
0.34	GO:0005515	protein binding
0.33	GO:0003723	RNA binding

0.42	GO:0005615	extracellular space
0.39	GO:1903561	extracellular vesicle

0.80

EC:3.2.1.1

GO:0004556

sp|P19971|TYPH_HUMAN
Thymidine phosphorylase
Search

TYMP

0.52	Pyrimidine-nucleoside phosphorylase

0.72	GO:0006206	pyrimidine nucleobase metabolic process
0.69	GO:0006213	pyrimidine nucleoside metabolic process
0.59	GO:1905333	regulation of gastric motility
0.56	GO:0051969	regulation of transmission of nerve impulse
0.56	GO:0031641	regulation of myelination
0.53	GO:0000002	mitochondrial genome maintenance
0.37	GO:0009653	anatomical structure morphogenesis
0.36	GO:0048731	system development
0.36	GO:0006935	chemotaxis
0.36	GO:0072529	pyrimidine-containing compound catabolic process

0.77	GO:0004645	phosphorylase activity
0.77	GO:0016154	pyrimidine-nucleoside phosphorylase activity
0.69	GO:0009032	thymidine phosphorylase activity
0.50	GO:0042803	protein homodimerization activity
0.36	GO:0008083	growth factor activity

0.41	GO:0005829	cytosol
0.34	GO:0031012	extracellular matrix
0.30	GO:0016020	membrane

0.77

EC:2.4.1.1

GO:0004645

sp|P20020|AT2B1_HUMAN
Plasma membrane calcium-transporting ATPase 1
Search

ATP2B1

0.60	Calcium-transporting ATPase

0.77	GO:0070588	calcium ion transmembrane transport
0.69	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.58	GO:1990034	calcium ion export across plasma membrane
0.53	GO:0006874	cellular calcium ion homeostasis
0.40	GO:0007423	sensory organ development
0.40	GO:0034505	tooth mineralization
0.39	GO:0048916	posterior lateral line development
0.39	GO:0071386	cellular response to corticosterone stimulus
0.39	GO:0007399	nervous system development
0.39	GO:0030282	bone mineralization

0.80	GO:0005388	calcium-transporting ATPase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0030165	PDZ domain binding
0.39	GO:0005516	calmodulin binding
0.36	GO:0036487	nitric-oxide synthase inhibitor activity
0.36	GO:0030346	protein phosphatase 2B binding
0.36	GO:0050998	nitric-oxide synthase binding

0.44	GO:0005634	nucleus
0.42	GO:0005886	plasma membrane
0.38	GO:0043197	dendritic spine
0.37	GO:0043025	neuronal cell body
0.37	GO:0070062	extracellular exosome
0.37	GO:0098857	membrane microdomain
0.37	GO:0045177	apical part of cell
0.37	GO:0031252	cell leading edge
0.37	GO:0098562	cytoplasmic side of membrane
0.35	GO:0036126	sperm flagellum

0.80

EC:3.6.3.8

GO:0005388

sp|P20023|CR2_HUMAN
Complement receptor type 2
Search

CR2

0.68	complement receptor type 2

0.61	GO:0042100	B cell proliferation
0.59	GO:0030183	B cell differentiation
0.47	GO:0002430	complement receptor mediated signaling pathway
0.43	GO:0030449	regulation of complement activation
0.41	GO:1900005	positive regulation of serine-type endopeptidase activity
0.41	GO:2000258	negative regulation of protein activation cascade
0.41	GO:0002921	negative regulation of humoral immune response
0.41	GO:0010955	negative regulation of protein processing
0.40	GO:0006958	complement activation, classical pathway
0.40	GO:1900004	negative regulation of serine-type endopeptidase activity

0.63	GO:0001848	complement binding
0.54	GO:0042803	protein homodimerization activity
0.47	GO:0004875	complement receptor activity
0.43	GO:0003677	DNA binding
0.40	GO:0001847	opsonin receptor activity
0.40	GO:0001846	opsonin binding
0.38	GO:0005509	calcium ion binding
0.37	GO:0001618	virus receptor activity
0.35	GO:0008061	chitin binding
0.33	GO:0003714	transcription corepressor activity

0.56	GO:0043235	receptor complex
0.43	GO:0009986	cell surface
0.41	GO:0070062	extracellular exosome
0.40	GO:0098552	side of membrane
0.39	GO:0044459	plasma membrane part
0.32	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|P20036|DPA1_HUMAN
HLA class II histocompatibility antigen, DP alpha 1 chain
Search

0.44	MHC class II DP alpha chain

0.81	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
0.72	GO:0006955	immune response
0.38	GO:0002478	antigen processing and presentation of exogenous peptide antigen
0.38	GO:0032729	positive regulation of interferon-gamma production
0.38	GO:0042102	positive regulation of T cell proliferation
0.37	GO:0071345	cellular response to cytokine stimulus
0.36	GO:0006952	defense response

0.38

GO:0042605

peptide antigen binding

0.74	GO:0042613	MHC class II protein complex
0.36	GO:0009986	cell surface
0.34	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

sp|P20042|IF2B_HUMAN
Eukaryotic translation initiation factor 2 subunit 2
Search

EIF2S2

0.92	Eukaryotic translation initiation factor 2 subunit beta

0.70	GO:0006413	translational initiation
0.53	GO:0002176	male germ cell proliferation
0.50	GO:0008584	male gonad development
0.46	GO:0001701	in utero embryonic development
0.32	GO:0055085	transmembrane transport

0.71	GO:0003743	translation initiation factor activity
0.35	GO:0005515	protein binding
0.35	GO:0046872	metal ion binding

0.53	GO:0005850	eukaryotic translation initiation factor 2 complex
0.34	GO:0005634	nucleus
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|P20061|TCO1_HUMAN
Transcobalamin-1
Search

TCN1

0.97	Transcobalamin-1

0.78	GO:0015889	cobalamin transport
0.41	GO:0043312	neutrophil degranulation
0.41	GO:0006824	cobalt ion transport
0.38	GO:0009235	cobalamin metabolic process
0.35	GO:0043043	peptide biosynthetic process
0.34	GO:0044267	cellular protein metabolic process
0.34	GO:0010467	gene expression
0.34	GO:0009059	macromolecule biosynthetic process

0.75	GO:0031419	cobalamin binding
0.35	GO:0003735	structural constituent of ribosome

0.42	GO:1904724	tertiary granule lumen
0.42	GO:0035580	specific granule lumen
0.40	GO:0005615	extracellular space
0.35	GO:0005840	ribosome
0.35	GO:0005902	microvillus
0.35	GO:0016324	apical plasma membrane
0.34	GO:0005768	endosome
0.30	GO:0031224	intrinsic component of membrane

sp|P20062|TCO2_HUMAN
Transcobalamin-2
Search

TCN2

0.97	Transcobalamin II

0.78	GO:0015889	cobalamin transport
0.44	GO:0006824	cobalt ion transport
0.36	GO:0009235	cobalamin metabolic process

0.75	GO:0031419	cobalamin binding
0.37	GO:0046872	metal ion binding
0.35	GO:0005515	protein binding

0.57	GO:0005615	extracellular space
0.39	GO:1903561	extracellular vesicle
0.39	GO:0043202	lysosomal lumen
0.37	GO:0005768	endosome

sp|P20073|ANXA7_HUMAN
Annexin A7
Search

ANXA7

0.65

Annexin

0.55	GO:0009992	cellular water homeostasis
0.55	GO:0035176	social behavior
0.51	GO:0030855	epithelial cell differentiation
0.51	GO:0009651	response to salt stress
0.51	GO:0007599	hemostasis
0.51	GO:0006914	autophagy
0.50	GO:0006874	cellular calcium ion homeostasis
0.50	GO:0008283	cell proliferation
0.46	GO:0010629	negative regulation of gene expression
0.46	GO:0008360	regulation of cell shape

0.80	GO:0005544	calcium-dependent phospholipid binding
0.69	GO:0005509	calcium ion binding
0.55	GO:0048306	calcium-dependent protein binding
0.54	GO:0005178	integrin binding
0.35	GO:0003723	RNA binding
0.33	GO:0008429	phosphatidylethanolamine binding
0.32	GO:0044548	S100 protein binding
0.32	GO:0042802	identical protein binding

0.57	GO:0042584	chromaffin granule membrane
0.48	GO:0005635	nuclear envelope
0.48	GO:0005789	endoplasmic reticulum membrane
0.46	GO:0005829	cytosol
0.40	GO:0005886	plasma membrane
0.38	GO:0070062	extracellular exosome
0.32	GO:0005766	primary lysosome
0.32	GO:0042581	specific granule
0.32	GO:0045335	phagocytic vesicle
0.32	GO:0030496	midbody

sp|P20132|SDHL_HUMAN
L-serine dehydratase/L-threonine deaminase
Search

SDS

0.54	L-serine dehydratase/L-threonine deaminase

0.59	GO:0006565	L-serine catabolic process
0.55	GO:0042866	pyruvate biosynthetic process
0.37	GO:0019319	hexose biosynthetic process
0.37	GO:0006006	glucose metabolic process
0.33	GO:0006468	protein phosphorylation

0.64	GO:0030170	pyridoxal phosphate binding
0.54	GO:0003941	L-serine ammonia-lyase activity
0.54	GO:0042802	identical protein binding
0.48	GO:0046983	protein dimerization activity
0.39	GO:0004794	L-threonine ammonia-lyase activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0005524	ATP binding

0.48	GO:0005829	cytosol
0.47	GO:0005739	mitochondrion
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.54

EC:4.3.1.17

GO:0003941

sp|P20138|CD33_HUMAN
Myeloid cell surface antigen CD33
Search

0.92	Sialic acid binding Ig like lectin 6

0.40	GO:0043312	neutrophil degranulation
0.40	GO:0007155	cell adhesion
0.37	GO:0050776	regulation of immune response
0.37	GO:0006898	receptor-mediated endocytosis
0.36	GO:0007267	cell-cell signaling
0.36	GO:0008285	negative regulation of cell proliferation
0.35	GO:0007165	signal transduction
0.35	GO:0060101	negative regulation of phagocytosis, engulfment
0.34	GO:0050728	negative regulation of inflammatory response
0.34	GO:0045087	innate immune response

0.48	GO:0030246	carbohydrate binding
0.41	GO:0033691	sialic acid binding
0.38	GO:0038024	cargo receptor activity
0.35	GO:0005515	protein binding
0.34	GO:0005057	signal transducer activity, downstream of receptor

0.48	GO:0009897	external side of plasma membrane
0.41	GO:0005634	nucleus
0.40	GO:0070821	tertiary granule membrane
0.38	GO:0035579	specific granule membrane
0.37	GO:0005887	integral component of plasma membrane
0.37	GO:0101003	ficolin-1-rich granule membrane
0.36	GO:0070062	extracellular exosome

sp|P20142|PEPC_HUMAN
Gastricsin
Search

PGC

0.83	Progastricsin

0.77	GO:0002803	positive regulation of antibacterial peptide production
0.61	GO:0006508	proteolysis
0.52	GO:0006914	autophagy
0.48	GO:0030163	protein catabolic process

0.70	GO:0070001	aspartic-type peptidase activity
0.65	GO:0004175	endopeptidase activity

0.64

GO:0005615

extracellular space

sp|P20151|KLK2_HUMAN
Kallikrein-2
Search

0.97	Prostate-specific antigen

0.61	GO:0006508	proteolysis
0.43	GO:0002778	antibacterial peptide production
0.40	GO:0022617	extracellular matrix disassembly
0.38	GO:0032101	regulation of response to external stimulus
0.38	GO:0031642	negative regulation of myelination
0.38	GO:0097186	amelogenesis
0.38	GO:0043616	keratinocyte proliferation
0.37	GO:0070571	negative regulation of neuron projection regeneration
0.37	GO:1903035	negative regulation of response to wounding
0.37	GO:0007613	memory

0.69	GO:0004252	serine-type endopeptidase activity
0.41	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
0.36	GO:0005057	signal transducer activity, downstream of receptor
0.35	GO:0008083	growth factor activity
0.34	GO:0090729	toxin activity
0.33	GO:0046872	metal ion binding

0.45	GO:0005615	extracellular space
0.39	GO:1903561	extracellular vesicle
0.39	GO:0005634	nucleus
0.39	GO:0043234	protein complex
0.38	GO:0030141	secretory granule
0.36	GO:0097223	sperm part
0.36	GO:0045177	apical part of cell
0.30	GO:0016020	membrane

0.69

GO:0004252

sp|P20155|ISK2_HUMAN
Serine protease inhibitor Kazal-type 2
Search

SPINK2

0.91	Pancreatic secretory trypsin inhibitor

0.69	GO:0010951	negative regulation of endopeptidase activity
0.67	GO:1902572	negative regulation of serine-type peptidase activity
0.67	GO:1900003	regulation of serine-type endopeptidase activity
0.63	GO:0002176	male germ cell proliferation
0.60	GO:0072520	seminiferous tubule development
0.58	GO:0007286	spermatid development
0.57	GO:0009566	fertilization
0.56	GO:0060046	regulation of acrosome reaction
0.55	GO:0043065	positive regulation of apoptotic process
0.47	GO:0006508	proteolysis

0.67	GO:0004867	serine-type endopeptidase inhibitor activity
0.48	GO:0008233	peptidase activity
0.37	GO:0005515	protein binding
0.34	GO:0005509	calcium ion binding

0.62	GO:0001669	acrosomal vesicle
0.54	GO:0043005	neuron projection
0.49	GO:0005615	extracellular space
0.30	GO:0016020	membrane

0.48

GO:0008233

sp|P20160|CAP7_HUMAN
Azurocidin
Search

AZU1

0.91	Myeloblastin

0.67	GO:0050754	positive regulation of fractalkine biosynthetic process
0.66	GO:0001909	leukocyte mediated cytotoxicity
0.66	GO:0050722	regulation of interleukin-1 beta biosynthetic process
0.65	GO:0045362	positive regulation of interleukin-1 biosynthetic process
0.64	GO:0045348	positive regulation of MHC class II biosynthetic process
0.64	GO:0001774	microglial cell activation
0.63	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
0.63	GO:0002443	leukocyte mediated immunity
0.63	GO:0051873	killing by host of symbiont cells
0.62	GO:0032731	positive regulation of interleukin-1 beta production

0.69	GO:0004252	serine-type endopeptidase activity
0.61	GO:0043395	heparan sulfate proteoglycan binding
0.58	GO:0008201	heparin binding
0.40	GO:0005509	calcium ion binding
0.39	GO:0015643	toxic substance binding
0.35	GO:0005102	receptor binding
0.35	GO:0019899	enzyme binding
0.33	GO:0004503	monophenol monooxygenase activity

0.63	GO:0042582	azurophil granule
0.59	GO:0030667	secretory granule membrane
0.57	GO:0005765	lysosomal membrane
0.55	GO:0005615	extracellular space
0.54	GO:0019898	extrinsic component of membrane
0.43	GO:0034774	secretory granule lumen
0.43	GO:0005775	vacuolar lumen
0.40	GO:1903561	extracellular vesicle
0.38	GO:0010494	cytoplasmic stress granule
0.36	GO:0044853	plasma membrane raft

0.69

GO:0004252

sp|P20226|TBP_HUMAN
TATA-box-binding protein
Search

TBP

0.63	TATA-binding protein 1

0.69	GO:0006352	DNA-templated transcription, initiation
0.56	GO:0006359	regulation of transcription by RNA polymerase III
0.55	GO:0006366	transcription by RNA polymerase II
0.55	GO:0006383	transcription by RNA polymerase III
0.51	GO:0065004	protein-DNA complex assembly
0.44	GO:0007369	gastrulation
0.41	GO:0006402	mRNA catabolic process
0.38	GO:0007283	spermatogenesis
0.37	GO:0045893	positive regulation of transcription, DNA-templated
0.36	GO:0009792	embryo development ending in birth or egg hatching

0.60	GO:0001034	RNA polymerase III transcription factor activity, sequence-specific DNA binding
0.58	GO:0001093	TFIIB-class transcription factor binding
0.57	GO:0017162	aryl hydrocarbon receptor binding
0.56	GO:0001129	RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly
0.55	GO:0070491	repressing transcription factor binding
0.55	GO:0003677	DNA binding
0.51	GO:0001067	regulatory region nucleic acid binding
0.49	GO:0019899	enzyme binding

0.57	GO:0097550	transcriptional preinitiation complex
0.57	GO:0001940	male pronucleus
0.56	GO:0001939	female pronucleus
0.55	GO:0005719	nuclear euchromatin
0.54	GO:0005669	transcription factor TFIID complex
0.54	GO:0005672	transcription factor TFIIA complex
0.38	GO:0005737	cytoplasm
0.35	GO:0000120	RNA polymerase I transcription factor complex

sp|P20231|TRYB2_HUMAN
Tryptase beta-2
Search

0.80	Mast cell tryptase beta III

0.61	GO:0006508	proteolysis
0.38	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
0.38	GO:0060672	epithelial cell morphogenesis involved in placental branching
0.37	GO:0022617	extracellular matrix disassembly
0.37	GO:0030216	keratinocyte differentiation
0.37	GO:0001843	neural tube closure
0.36	GO:0050878	regulation of body fluid levels
0.36	GO:0050819	negative regulation of coagulation
0.36	GO:0061045	negative regulation of wound healing
0.35	GO:0006952	defense response

0.69	GO:0004252	serine-type endopeptidase activity
0.39	GO:0008201	heparin binding
0.36	GO:0005515	protein binding
0.34	GO:0005044	scavenger receptor activity
0.33	GO:0005509	calcium ion binding

0.44	GO:0005576	extracellular region
0.37	GO:0042629	mast cell granule
0.37	GO:0019897	extrinsic component of plasma membrane
0.35	GO:0016323	basolateral plasma membrane
0.33	GO:0046658	anchored component of plasma membrane
0.33	GO:0043025	neuronal cell body
0.32	GO:0031982	vesicle
0.32	GO:0005887	integral component of plasma membrane

0.69

GO:0004252

sp|P20248|CCNA2_HUMAN
Cyclin-A2
Search

0.62

Cyclin A

0.59	GO:0000086	G2/M transition of mitotic cell cycle
0.58	GO:0016572	histone phosphorylation
0.58	GO:0044843	cell cycle G1/S phase transition
0.56	GO:0007265	Ras protein signal transduction
0.52	GO:0045893	positive regulation of transcription, DNA-templated
0.51	GO:0051726	regulation of cell cycle
0.44	GO:0007423	sensory organ development
0.42	GO:0071373	cellular response to luteinizing hormone stimulus
0.42	GO:0071314	cellular response to cocaine
0.42	GO:1990314	cellular response to insulin-like growth factor stimulus

0.57	GO:0097472	cyclin-dependent protein kinase activity
0.54	GO:0019901	protein kinase binding
0.53	GO:0019904	protein domain specific binding
0.36	GO:0001103	RNA polymerase II repressing transcription factor binding

0.62	GO:0097124	cyclin A2-CDK2 complex
0.61	GO:0005634	nucleus
0.49	GO:0005829	cytosol
0.49	GO:0031974	membrane-enclosed lumen
0.44	GO:0044446	intracellular organelle part
0.37	GO:0097123	cyclin A1-CDK2 complex
0.36	GO:0015630	microtubule cytoskeleton
0.35	GO:0001750	photoreceptor outer segment
0.35	GO:0034464	BBSome
0.35	GO:0097014	ciliary plasm

sp|P20264|PO3F3_HUMAN
POU domain, class 3, transcription factor 3
Search

sp|P20265|PO3F2_HUMAN
POU domain, class 3, transcription factor 2
Search

0.57	POU domain, class 3, transcription factor 2-B

0.75	GO:0007420	brain development
0.67	GO:0006357	regulation of transcription by RNA polymerase II
0.58	GO:0006351	transcription, DNA-templated
0.50	GO:0061351	neural precursor cell proliferation
0.50	GO:0030182	neuron differentiation
0.49	GO:0014002	astrocyte development
0.49	GO:0008284	positive regulation of cell proliferation
0.48	GO:0022011	myelination in peripheral nervous system
0.48	GO:0040018	positive regulation of multicellular organism growth
0.48	GO:2001054	negative regulation of mesenchymal cell apoptotic process

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.51	GO:0001012	RNA polymerase II regulatory region DNA binding
0.48	GO:0003690	double-stranded DNA binding
0.48	GO:0001105	RNA polymerase II transcription coactivator activity
0.45	GO:0042802	identical protein binding
0.43	GO:0071837	HMG box domain binding
0.32	GO:0016817	hydrolase activity, acting on acid anhydrides
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding

0.61	GO:0005634	nucleus
0.44	GO:0005667	transcription factor complex
0.30	GO:0016020	membrane

0.32

EC:3.6

GO:0016817

sp|P20273|CD22_HUMAN
B-cell receptor CD22
Search

CD22

0.86	B-cell receptor CD22

0.42	GO:0007155	cell adhesion
0.36	GO:0035640	exploration behavior
0.36	GO:0008344	adult locomotory behavior
0.36	GO:0043524	negative regulation of neuron apoptotic process
0.36	GO:0001764	neuron migration
0.36	GO:0050890	cognition
0.36	GO:0007411	axon guidance
0.35	GO:0007166	cell surface receptor signaling pathway
0.33	GO:0031103	axon regeneration
0.32	GO:0033334	fin morphogenesis

0.41	GO:0030246	carbohydrate binding
0.38	GO:0005515	protein binding
0.37	GO:0015026	coreceptor activity
0.33	GO:0005509	calcium ion binding

0.41	GO:0070062	extracellular exosome
0.39	GO:0009897	external side of plasma membrane
0.37	GO:0005887	integral component of plasma membrane
0.36	GO:0030425	dendrite
0.36	GO:0045177	apical part of cell
0.32	GO:0005578	proteinaceous extracellular matrix

sp|P20290|BTF3_HUMAN
Transcription factor BTF3
Search

BTF3

0.78	Transcription factor BTF3

0.67	GO:0001701	in utero embryonic development
0.45	GO:0015031	protein transport
0.44	GO:0006366	transcription by RNA polymerase II
0.41	GO:2001141	regulation of RNA biosynthetic process
0.41	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.41	GO:0010468	regulation of gene expression
0.41	GO:0006364	rRNA processing

0.42	GO:0003723	RNA binding
0.40	GO:0005515	protein binding

0.63	GO:0005829	cytosol
0.46	GO:0005634	nucleus
0.40	GO:0031974	membrane-enclosed lumen
0.38	GO:0043232	intracellular non-membrane-bounded organelle
0.38	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|P20292|AL5AP_HUMAN
Arachidonate 5-lipoxygenase-activating protein
Search

ALOX5AP

0.97	Arachidonate 5-lipoxygenase-activating protein isoform 1

0.86	GO:0006691	leukotriene metabolic process
0.73	GO:0043085	positive regulation of catalytic activity
0.65	GO:0002540	leukotriene production involved in inflammatory response
0.65	GO:0046456	icosanoid biosynthetic process
0.44	GO:0001525	angiogenesis
0.42	GO:0019372	lipoxygenase pathway
0.41	GO:0070207	protein homotrimerization
0.40	GO:0002675	positive regulation of acute inflammatory response
0.40	GO:0071277	cellular response to calcium ion
0.37	GO:2001300	lipoxin metabolic process

0.75	GO:0008047	enzyme activator activity
0.54	GO:0004464	leukotriene-C4 synthase activity
0.48	GO:0050544	arachidonic acid binding
0.48	GO:0004364	glutathione transferase activity
0.48	GO:0004602	glutathione peroxidase activity
0.41	GO:0004051	arachidonate 5-lipoxygenase activity
0.39	GO:0047485	protein N-terminus binding
0.38	GO:0042803	protein homodimerization activity
0.38	GO:0046982	protein heterodimerization activity
0.37	GO:0019899	enzyme binding

0.49	GO:0005634	nucleus
0.47	GO:0005783	endoplasmic reticulum
0.43	GO:0031967	organelle envelope
0.43	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.41	GO:0031984	organelle subcompartment
0.39	GO:0031090	organelle membrane
0.37	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.54	EC:4.4.1.20	GO:0004464
0.54	KEGG:R03059	GO:0004464

sp|P20309|ACM3_HUMAN
Muscarinic acetylcholine receptor M3
Search

CHRM3

0.81	Muscarinic acetylcholine receptor

0.85	GO:0046541	saliva secretion
0.84	GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
0.83	GO:0045987	positive regulation of smooth muscle contraction
0.52	GO:0003056	regulation of vascular smooth muscle contraction
0.51	GO:0007271	synaptic transmission, cholinergic
0.50	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.50	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
0.49	GO:0006939	smooth muscle contraction
0.48	GO:0001696	gastric acid secretion
0.44	GO:0015872	dopamine transport

0.85	GO:0016907	G-protein coupled acetylcholine receptor activity
0.46	GO:0042166	acetylcholine binding
0.35	GO:0005515	protein binding
0.35	GO:0004435	phosphatidylinositol phospholipase C activity
0.34	GO:0016934	extracellularly glycine-gated chloride channel activity
0.34	GO:0098772	molecular function regulator

0.79	GO:0045211	postsynaptic membrane
0.74	GO:0030054	cell junction
0.66	GO:0005887	integral component of plasma membrane
0.43	GO:0016323	basolateral plasma membrane
0.41	GO:0043679	axon terminus
0.41	GO:0032279	asymmetric synapse
0.40	GO:0030425	dendrite

0.35	EC:3.1.4.11	GO:0004435
0.35	KEGG:R03435	GO:0004435

sp|P20333|TNR1B_HUMAN
Tumor necrosis factor receptor superfamily member 1B
Search

TNFRSF1B

0.97	Tumor necrosis factor receptor 2

0.85	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.77	GO:0006954	inflammatory response
0.69	GO:0051044	positive regulation of membrane protein ectodomain proteolysis
0.68	GO:0050779	RNA destabilization
0.66	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
0.66	GO:0097191	extrinsic apoptotic signaling pathway
0.66	GO:0050728	negative regulation of inflammatory response
0.65	GO:0071222	cellular response to lipopolysaccharide
0.48	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.45	GO:0006955	immune response

0.86	GO:0005031	tumor necrosis factor-activated receptor activity
0.62	GO:0031625	ubiquitin protein ligase binding
0.32	GO:0016787	hydrolase activity

0.63	GO:0045121	membrane raft
0.47	GO:0043196	varicosity
0.44	GO:0043025	neuronal cell body
0.43	GO:0048471	perinuclear region of cytoplasm
0.42	GO:0005887	integral component of plasma membrane
0.40	GO:0035579	specific granule membrane
0.38	GO:0005634	nucleus
0.36	GO:0005576	extracellular region

0.32

GO:0016787

sp|P20336|RAB3A_HUMAN
Ras-related protein Rab-3A
Search

RAB3A

0.97	RAB3A, member RAS oncogene family

0.66	GO:0017157	regulation of exocytosis
0.61	GO:0061670	evoked neurotransmitter secretion
0.61	GO:0048790	maintenance of presynaptic active zone structure
0.59	GO:0048172	regulation of short-term neuronal synaptic plasticity
0.59	GO:0003016	respiratory system process
0.59	GO:0050975	sensory perception of touch
0.59	GO:0051602	response to electrical stimulus
0.59	GO:0016188	synaptic vesicle maturation
0.58	GO:1902803	regulation of synaptic vesicle transport
0.58	GO:0098693	regulation of synaptic vesicle cycle

0.70	GO:0031489	myosin V binding
0.70	GO:0030742	GTP-dependent protein binding
0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0051021	GDP-dissociation inhibitor binding
0.36	GO:0051117	ATPase binding
0.36	GO:0008022	protein C-terminus binding

0.64	GO:0008021	synaptic vesicle
0.57	GO:0043195	terminal bouton
0.56	GO:0001669	acrosomal vesicle
0.53	GO:0048471	perinuclear region of cytoplasm
0.52	GO:0005768	endosome
0.36	GO:0099501	exocytic vesicle membrane
0.36	GO:0005829	cytosol
0.36	GO:0031225	anchored component of membrane
0.35	GO:0031300	intrinsic component of organelle membrane
0.34	GO:0043234	protein complex

sp|P20337|RAB3B_HUMAN
Ras-related protein Rab-3B
Search

RAB3B

0.96	RAB3B, member RAS oncogene family

0.58	GO:0017157	regulation of exocytosis
0.57	GO:0051944	positive regulation of catecholamine uptake involved in synaptic transmission
0.56	GO:0097494	regulation of vesicle size
0.56	GO:0018125	peptidyl-cysteine methylation
0.56	GO:0051584	regulation of dopamine uptake involved in synaptic transmission
0.56	GO:0032226	positive regulation of synaptic transmission, dopaminergic
0.55	GO:0019882	antigen processing and presentation
0.54	GO:2001025	positive regulation of response to drug
0.52	GO:0043270	positive regulation of ion transport
0.37	GO:0015031	protein transport

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.62	GO:0031489	myosin V binding
0.62	GO:0030742	GTP-dependent protein binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0004871	signal transducer activity
0.32	GO:0046872	metal ion binding
0.32	GO:0016491	oxidoreductase activity

0.58	GO:0008021	synaptic vesicle
0.57	GO:0048471	perinuclear region of cytoplasm
0.51	GO:0030141	secretory granule
0.39	GO:0099501	exocytic vesicle membrane
0.38	GO:0031225	anchored component of membrane
0.37	GO:0031300	intrinsic component of organelle membrane
0.37	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome
0.36	GO:0005886	plasma membrane
0.34	GO:1905360	GTPase complex

0.32

GO:0016491

sp|P20338|RAB4A_HUMAN
Ras-related protein Rab-4A
Search

RAB4A

0.97	RAB4A, member RAS oncogene family variant (Fragment)

0.61	GO:0030100	regulation of endocytosis
0.55	GO:0019882	antigen processing and presentation
0.49	GO:0015031	protein transport
0.48	GO:0001944	vasculature development
0.38	GO:0032482	Rab protein signal transduction
0.37	GO:0032781	positive regulation of ATPase activity

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0008565	protein transporter activity
0.38	GO:0035255	ionotropic glutamate receptor binding
0.38	GO:0051117	ATPase binding
0.37	GO:0019905	syntaxin binding
0.37	GO:0001671	ATPase activator activity

0.58	GO:0070062	extracellular exosome
0.57	GO:0005768	endosome
0.57	GO:0048471	perinuclear region of cytoplasm
0.53	GO:0032593	insulin-responsive compartment
0.36	GO:0098794	postsynapse
0.35	GO:0005829	cytosol
0.34	GO:0043231	intracellular membrane-bounded organelle
0.34	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P20339|RAB5A_HUMAN
Ras-related protein Rab-5A
Search

RAB5A

0.87	Putative rab subfamily protein of small gtpase

0.54	GO:0051489	regulation of filopodium assembly
0.53	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway
0.52	GO:0060627	regulation of vesicle-mediated transport
0.52	GO:0051036	regulation of endosome size
0.51	GO:0045056	transcytosis
0.51	GO:0045022	early endosome to late endosome transport
0.51	GO:0098693	regulation of synaptic vesicle cycle
0.50	GO:0046928	regulation of neurotransmitter secretion
0.50	GO:0036465	synaptic vesicle recycling
0.49	GO:1903532	positive regulation of secretion by cell

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.51	GO:0019003	GDP binding
0.35	GO:0051021	GDP-dissociation inhibitor binding
0.34	GO:0004402	histone acetyltransferase activity
0.32	GO:0046872	metal ion binding

0.54	GO:0005769	early endosome
0.54	GO:0030139	endocytic vesicle
0.52	GO:0001726	ruffle
0.51	GO:0010009	cytoplasmic side of endosome membrane
0.50	GO:0098857	membrane microdomain
0.50	GO:0043195	terminal bouton
0.48	GO:0036477	somatodendritic compartment
0.48	GO:0015629	actin cytoskeleton
0.44	GO:0005829	cytosol
0.42	GO:0005886	plasma membrane

0.34

EC:2.3.1.48

GO:0004402

sp|P20340|RAB6A_HUMAN
Ras-related protein Rab-6A
Search

0.43	Putative rab subfamily protein of small gtpase

0.46	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.46	GO:0006891	intra-Golgi vesicle-mediated transport
0.46	GO:0042147	retrograde transport, endosome to Golgi
0.45	GO:0045467	R7 cell development
0.45	GO:0008103	oocyte microtubule cytoskeleton polarization
0.45	GO:0045451	pole plasm oskar mRNA localization
0.44	GO:0007293	germarium-derived egg chamber formation
0.43	GO:0050832	defense response to fungus
0.42	GO:0007411	axon guidance
0.42	GO:0060078	regulation of postsynaptic membrane potential

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0032561	guanyl ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0031489	myosin V binding
0.37	GO:0019904	protein domain specific binding
0.35	GO:0051117	ATPase binding
0.34	GO:0001671	ATPase activator activity
0.34	GO:0003779	actin binding

0.52	GO:0005794	Golgi apparatus
0.42	GO:0005829	cytosol
0.42	GO:0031410	cytoplasmic vesicle
0.38	GO:0098588	bounding membrane of organelle
0.37	GO:0031984	organelle subcompartment
0.36	GO:0070062	extracellular exosome
0.34	GO:0043204	perikaryon
0.34	GO:0012506	vesicle membrane
0.34	GO:0045202	synapse
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network

sp|P20366|TKN1_HUMAN
Protachykinin-1
Search

0.73	Tachykinin precursor 1

0.85	GO:0007217	tachykinin receptor signaling pathway
0.51	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.50	GO:1990090	cellular response to nerve growth factor stimulus
0.50	GO:0006954	inflammatory response
0.50	GO:0048265	response to pain
0.49	GO:0019233	sensory perception of pain
0.43	GO:0007267	cell-cell signaling
0.42	GO:0007218	neuropeptide signaling pathway
0.30	GO:0050671	positive regulation of lymphocyte proliferation
0.30	GO:0051272	positive regulation of cellular component movement

0.41	GO:0005102	receptor binding
0.30	GO:0098772	molecular function regulator

0.48	GO:0043025	neuronal cell body
0.47	GO:0030424	axon
0.47	GO:0005576	extracellular region
0.30	GO:0016020	membrane
0.30	GO:0071944	cell periphery

sp|P20382|MCH_HUMAN
Pro-MCH
Search

PMCH

0.97	Pro-melanin concentrating hormone

0.78	GO:0007268	chemical synaptic transmission
0.76	GO:0010469	regulation of receptor activity
0.62	GO:0007631	feeding behavior
0.41	GO:0007218	neuropeptide signaling pathway
0.37	GO:0046005	positive regulation of circadian sleep/wake cycle, REM sleep
0.37	GO:0032227	negative regulation of synaptic transmission, dopaminergic
0.36	GO:0007595	lactation
0.36	GO:0045776	negative regulation of blood pressure
0.36	GO:0048168	regulation of neuronal synaptic plasticity
0.36	GO:0002027	regulation of heart rate

0.87	GO:0030354	melanin-concentrating hormone activity
0.38	GO:0031777	type 1 melanin-concentrating hormone receptor binding

0.49	GO:0005634	nucleus
0.40	GO:0005576	extracellular region
0.33	GO:0012505	endomembrane system
0.33	GO:0031967	organelle envelope
0.33	GO:0043234	protein complex
0.30	GO:0016020	membrane

sp|P20393|NR1D1_HUMAN
Nuclear receptor subfamily 1 group D member 1
Search

NR1D1

0.95	Nuclear receptor Rev-ErbA-alpha

0.78	GO:0043401	steroid hormone mediated signaling pathway
0.64	GO:0060086	circadian temperature homeostasis
0.63	GO:0070859	positive regulation of bile acid biosynthetic process
0.62	GO:0061469	regulation of type B pancreatic cell proliferation
0.62	GO:2000188	regulation of cholesterol homeostasis
0.62	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway
0.61	GO:0010871	negative regulation of receptor biosynthetic process
0.61	GO:0042752	regulation of circadian rhythm
0.61	GO:0035947	regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
0.61	GO:0032922	circadian regulation of gene expression

0.80	GO:0003707	steroid hormone receptor activity
0.64	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0001222	transcription corepressor binding
0.61	GO:0003700	DNA binding transcription factor activity
0.60	GO:0001047	core promoter binding
0.56	GO:0001012	RNA polymerase II regulatory region DNA binding
0.54	GO:0003690	double-stranded DNA binding
0.47	GO:0020037	heme binding
0.42	GO:0035326	enhancer binding

0.61	GO:0005634	nucleus
0.59	GO:0043197	dendritic spine
0.52	GO:0000785	chromatin
0.51	GO:0070013	intracellular organelle lumen
0.40	GO:0005737	cytoplasm
0.35	GO:0043025	neuronal cell body
0.30	GO:0016020	membrane

sp|P20396|TRH_HUMAN
Pro-thyrotropin-releasing hormone
Search

TRH

0.96	Pro-thyrotropin-releasing hormone

0.77	GO:0009755	hormone-mediated signaling pathway
0.75	GO:0010469	regulation of receptor activity
0.54	GO:0014050	negative regulation of glutamate secretion
0.53	GO:0014054	positive regulation of gamma-aminobutyric acid secretion
0.53	GO:0001692	histamine metabolic process
0.51	GO:0042755	eating behavior
0.50	GO:0032024	positive regulation of insulin secretion
0.43	GO:0007628	adult walking behavior
0.41	GO:0051412	response to corticosterone
0.41	GO:2000252	negative regulation of feeding behavior

0.87	GO:0008437	thyrotropin-releasing hormone activity
0.33	GO:0016907	G-protein coupled acetylcholine receptor activity
0.33	GO:0001671	ATPase activator activity
0.32	GO:0051087	chaperone binding
0.32	GO:0046872	metal ion binding
0.32	GO:0003676	nucleic acid binding

0.66	GO:0005576	extracellular region
0.48	GO:0030141	secretory granule
0.41	GO:0005634	nucleus
0.39	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P20472|PRVA_HUMAN
Parvalbumin alpha
Search

PVALB

0.85	Parvalbumin alpha

0.40

GO:0051480

regulation of cytosolic calcium ion concentration

0.70	GO:0005509	calcium ion binding
0.39	GO:0042803	protein homodimerization activity
0.38	GO:0046982	protein heterodimerization activity
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.52	GO:0030424	axon
0.40	GO:0043679	axon terminus
0.40	GO:0043025	neuronal cell body
0.38	GO:0005737	cytoplasm
0.36	GO:0070062	extracellular exosome
0.36	GO:0005634	nucleus
0.36	GO:0043234	protein complex

sp|P20585|MSH3_HUMAN
DNA mismatch repair protein Msh3
Search

MSH3

0.97	Novel protein similar to vertebrate mutS homolog 3 (E. coli) (MSH3)

0.75	GO:0006298	mismatch repair
0.72	GO:0051096	positive regulation of helicase activity
0.65	GO:0045910	negative regulation of DNA recombination
0.64	GO:0043570	maintenance of DNA repeat elements
0.58	GO:0016447	somatic recombination of immunoglobulin gene segments
0.39	GO:0016446	somatic hypermutation of immunoglobulin genes

0.76	GO:0030983	mismatched DNA binding
0.60	GO:0003697	single-stranded DNA binding
0.59	GO:0000406	double-strand/single-strand DNA junction binding
0.58	GO:0019899	enzyme binding
0.58	GO:0000403	Y-form DNA binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0003684	damaged DNA binding
0.49	GO:0008094	DNA-dependent ATPase activity

0.73	GO:0032302	MutSbeta complex
0.30	GO:0016020	membrane

sp|P20591|MX1_HUMAN
Interferon-induced GTP-binding protein Mx1
Search

MX1

0.83	Myxovirus resistance protein 1

0.41	GO:0035455	response to interferon-alpha
0.41	GO:0051607	defense response to virus
0.41	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission
0.40	GO:0046822	regulation of nucleocytoplasmic transport
0.39	GO:0000266	mitochondrial fission
0.38	GO:0045087	innate immune response
0.38	GO:0051726	regulation of cell cycle
0.37	GO:0061025	membrane fusion

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0008017	microtubule binding

0.39	GO:0005643	nuclear pore
0.36	GO:0031966	mitochondrial membrane

sp|P20592|MX2_HUMAN
Interferon-induced GTP-binding protein Mx2
Search

MX2

0.96	Myxovirus resistance protein 2

0.44	GO:0035455	response to interferon-alpha
0.43	GO:0046822	regulation of nucleocytoplasmic transport
0.42	GO:0051607	defense response to virus
0.41	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission
0.40	GO:0051726	regulation of cell cycle
0.40	GO:0000266	mitochondrial fission
0.39	GO:0045087	innate immune response
0.37	GO:0061025	membrane fusion

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0032561	guanyl ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0008017	microtubule binding

0.41	GO:0005643	nuclear pore
0.36	GO:0031966	mitochondrial membrane

sp|P20594|ANPRB_HUMAN
Atrial natriuretic peptide receptor 2
Search

NPR2

0.56	Guanylate cyclase

0.82	GO:0006182	cGMP biosynthetic process
0.64	GO:0007168	receptor guanylyl cyclase signaling pathway
0.63	GO:0006468	protein phosphorylation
0.62	GO:0035556	intracellular signal transduction
0.61	GO:1900194	negative regulation of oocyte maturation
0.61	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus
0.57	GO:0051447	negative regulation of meiotic cell cycle
0.56	GO:0060348	bone development
0.51	GO:0022414	reproductive process
0.45	GO:0060038	cardiac muscle cell proliferation

0.82	GO:0004383	guanylate cyclase activity
0.66	GO:0016941	natriuretic peptide receptor activity
0.63	GO:0004672	protein kinase activity
0.61	GO:0017046	peptide hormone binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0042802	identical protein binding
0.46	GO:0004016	adenylate cyclase activity
0.35	GO:0019901	protein kinase binding

0.48	GO:0005887	integral component of plasma membrane
0.48	GO:0008074	guanylate cyclase complex, soluble
0.40	GO:0043235	receptor complex

0.82

GO:0004383

sp|P20618|PSB1_HUMAN
Proteasome subunit beta type-1
Search

PSMB1

0.53	Proteasome subunit beta type

0.72	GO:0051603	proteolysis involved in cellular protein catabolic process
0.36	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.35	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:1902036	regulation of hematopoietic stem cell differentiation
0.35	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
0.35	GO:0043312	neutrophil degranulation
0.35	GO:0043632	modification-dependent macromolecule catabolic process

0.77	GO:0070003	threonine-type peptidase activity
0.65	GO:0004175	endopeptidase activity
0.33	GO:0005515	protein binding

0.76	GO:0005839	proteasome core complex
0.60	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.36	GO:0070062	extracellular exosome
0.35	GO:0031983	vesicle lumen
0.35	GO:0070013	intracellular organelle lumen
0.34	GO:0097708	intracellular vesicle
0.33	GO:0044446	intracellular organelle part
0.33	GO:0012505	endomembrane system

sp|P20645|MPRD_HUMAN
Cation-dependent mannose-6-phosphate receptor
Search

M6PR

0.96	Cation-dependent mannose-6-phosphate receptor

0.86	GO:0015761	mannose transport
0.61	GO:0033299	secretion of lysosomal enzymes
0.41	GO:0007041	lysosomal transport
0.40	GO:0061462	protein localization to lysosome
0.40	GO:0006623	protein targeting to vacuole
0.35	GO:0016197	endosomal transport
0.34	GO:0006898	receptor-mediated endocytosis
0.34	GO:0061024	membrane organization
0.33	GO:0007165	signal transduction

0.86	GO:0015578	mannose transmembrane transporter activity
0.85	GO:0005537	mannose binding
0.63	GO:1905394	retromer complex binding
0.38	GO:0019904	protein domain specific binding
0.34	GO:0004888	transmembrane signaling receptor activity

0.77	GO:0000323	lytic vacuole
0.57	GO:0030904	retromer complex
0.55	GO:0005770	late endosome
0.55	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0005802	trans-Golgi network
0.39	GO:0005774	vacuolar membrane
0.35	GO:0030665	clathrin-coated vesicle membrane
0.35	GO:0030133	transport vesicle
0.35	GO:0000139	Golgi membrane
0.34	GO:0005887	integral component of plasma membrane

sp|P20648|ATP4A_HUMAN
Potassium-transporting ATPase alpha chain 1
Search

ATP4A

0.63	Sodium/potassium-transporting ATPase subunit alpha

0.83	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
0.74	GO:0090662	ATP hydrolysis coupled transmembrane transport
0.71	GO:0006814	sodium ion transport
0.70	GO:0006813	potassium ion transport
0.62	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.57	GO:0015988	energy coupled proton transmembrane transport, against electrochemical gradient
0.40	GO:0006885	regulation of pH
0.39	GO:0055075	potassium ion homeostasis
0.38	GO:0010155	regulation of proton transport
0.36	GO:0001696	gastric acid secretion

0.83	GO:0005391	sodium:potassium-exchanging ATPase activity
0.69	GO:0008900	potassium:proton exchanging ATPase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0046872	metal ion binding
0.36	GO:0046982	protein heterodimerization activity

0.39	GO:0098590	plasma membrane region
0.36	GO:0045177	apical part of cell
0.36	GO:0005615	extracellular space
0.34	GO:0005887	integral component of plasma membrane

0.83

EC:3.6.3.9

GO:0005391

sp|P20671|H2A1D_HUMAN
Histone H2A type 1-D
Search

0.10	Histone H2A type 1-D

0.51	GO:0006342	chromatin silencing
0.34	GO:0006334	nucleosome assembly

0.74	GO:0046982	protein heterodimerization activity
0.55	GO:0003677	DNA binding
0.35	GO:0019899	enzyme binding

0.74	GO:0000786	nucleosome
0.61	GO:0005634	nucleus
0.45	GO:0031974	membrane-enclosed lumen
0.38	GO:0070062	extracellular exosome

sp|P20674|COX5A_HUMAN
Cytochrome c oxidase subunit 5A, mitochondrial
Search

COX5A

0.87	Cytochrome c oxidase polypeptide Va

0.62	GO:1902600	hydrogen ion transmembrane transport
0.60	GO:0022900	electron transport chain
0.42	GO:0006119	oxidative phosphorylation
0.42	GO:0009060	aerobic respiration
0.35	GO:0021522	spinal cord motor neuron differentiation
0.34	GO:0048568	embryonic organ development

0.64	GO:0015002	heme-copper terminal oxidase activity
0.64	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.62	GO:0015078	hydrogen ion transmembrane transporter activity
0.61	GO:0009055	electron transfer activity
0.40	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding
0.32	GO:0003676	nucleic acid binding

0.61	GO:0031966	mitochondrial membrane
0.61	GO:0019866	organelle inner membrane
0.51	GO:0043209	myelin sheath
0.51	GO:0045277	respiratory chain complex IV
0.51	GO:0098798	mitochondrial protein complex
0.37	GO:0070062	extracellular exosome

0.64

GO:0016676

sp|P20700|LMNB1_HUMAN
Lamin-B1
Search

0.69

Lamin

0.37	GO:1904609	cellular response to monosodium L-glutamate
0.36	GO:0071386	cellular response to corticosterone stimulus
0.36	GO:0031662	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
0.36	GO:0035722	interleukin-12-mediated signaling pathway
0.35	GO:0046330	positive regulation of JNK cascade
0.34	GO:0006915	apoptotic process
0.34	GO:0022008	neurogenesis
0.34	GO:0046677	response to antibiotic
0.34	GO:0042493	response to drug
0.32	GO:0043043	peptide biosynthetic process

0.62	GO:0005198	structural molecule activity
0.57	GO:0043274	phospholipase binding
0.36	GO:0008432	JUN kinase binding

0.79	GO:0005882	intermediate filament
0.61	GO:0005652	nuclear lamina
0.57	GO:0031965	nuclear membrane
0.55	GO:0016363	nuclear matrix
0.48	GO:0005654	nucleoplasm
0.45	GO:0019866	organelle inner membrane
0.32	GO:0005737	cytoplasm
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0031224	intrinsic component of membrane

sp|P20701|ITAL_HUMAN
Integrin alpha-L
Search

ITGAL

0.97	Lymphocyte function-associated antigen-1 alpha subunit

0.80	GO:0007229	integrin-mediated signaling pathway
0.72	GO:0007155	cell adhesion
0.61	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
0.57	GO:0043113	receptor clustering
0.42	GO:0050798	activated T cell proliferation
0.41	GO:0006909	phagocytosis
0.40	GO:0050850	positive regulation of calcium-mediated signaling
0.40	GO:0042102	positive regulation of T cell proliferation
0.38	GO:0006952	defense response
0.38	GO:0002274	myeloid leukocyte activation

0.61	GO:0030369	ICAM-3 receptor activity
0.54	GO:0050839	cell adhesion molecule binding
0.40	GO:0046982	protein heterodimerization activity
0.40	GO:0032403	protein complex binding
0.35	GO:0001851	complement component C3b binding
0.35	GO:0046872	metal ion binding
0.35	GO:0031072	heat shock protein binding
0.35	GO:0043395	heparan sulfate proteoglycan binding
0.34	GO:0008201	heparin binding
0.32	GO:0003735	structural constituent of ribosome

0.81	GO:0008305	integrin complex
0.54	GO:0009986	cell surface
0.41	GO:0098552	side of membrane
0.40	GO:0001772	immunological synapse
0.40	GO:0070062	extracellular exosome
0.38	GO:0005911	cell-cell junction
0.37	GO:0035579	specific granule membrane
0.35	GO:0044853	plasma membrane raft
0.34	GO:0101003	ficolin-1-rich granule membrane
0.33	GO:0070821	tertiary granule membrane

sp|P20702|ITAX_HUMAN
Integrin alpha-X
Search

0.92	Integrin subunit alpha X

0.80	GO:0007229	integrin-mediated signaling pathway
0.72	GO:0007155	cell adhesion
0.60	GO:0043315	positive regulation of neutrophil degranulation
0.58	GO:0010668	ectodermal cell differentiation
0.58	GO:0032930	positive regulation of superoxide anion generation
0.52	GO:0050798	activated T cell proliferation
0.50	GO:1903533	regulation of protein targeting
0.49	GO:0090316	positive regulation of intracellular protein transport
0.49	GO:2000363	positive regulation of prostaglandin-E synthase activity
0.48	GO:0045963	negative regulation of dopamine metabolic process

0.52	GO:0031072	heat shock protein binding
0.48	GO:0001851	complement component C3b binding
0.45	GO:0043395	heparan sulfate proteoglycan binding
0.43	GO:0008201	heparin binding
0.42	GO:0046982	protein heterodimerization activity
0.38	GO:0046872	metal ion binding
0.36	GO:0004872	receptor activity
0.34	GO:0003735	structural constituent of ribosome

0.81	GO:0008305	integrin complex
0.57	GO:0009986	cell surface
0.55	GO:0044853	plasma membrane raft
0.50	GO:0005615	extracellular space
0.50	GO:0098552	side of membrane
0.43	GO:1903561	extracellular vesicle
0.42	GO:0070821	tertiary granule membrane
0.40	GO:0101003	ficolin-1-rich granule membrane
0.38	GO:0005634	nucleus
0.37	GO:0035579	specific granule membrane

sp|P20711|DDC_HUMAN
Aromatic-L-amino-acid decarboxylase
Search

DDC

0.74	Aromatic-L-amino-acid decarboxylase

0.60	GO:0006520	cellular amino acid metabolic process
0.48	GO:0009636	response to toxic substance
0.45	GO:0042416	dopamine biosynthetic process
0.43	GO:0033076	isoquinoline alkaloid metabolic process
0.42	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle
0.42	GO:0007275	multicellular organism development
0.42	GO:0052314	phytoalexin metabolic process
0.42	GO:0060322	head development
0.42	GO:0042427	serotonin biosynthetic process
0.42	GO:0071312	cellular response to alkaloid

0.68	GO:0016831	carboxy-lyase activity
0.67	GO:0030170	pyridoxal phosphate binding
0.49	GO:0019899	enzyme binding
0.39	GO:0019904	protein domain specific binding
0.39	GO:0016597	amino acid binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.40	GO:0008021	synaptic vesicle
0.40	GO:0043025	neuronal cell body
0.40	GO:0030424	axon
0.36	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.68

EC:4.1.1

GO:0016831

sp|P20718|GRAH_HUMAN
Granzyme H
Search

0.96	Endogenous granzyme B

0.66	GO:0008626	granzyme-mediated apoptotic signaling pathway
0.61	GO:0042267	natural killer cell mediated cytotoxicity
0.61	GO:0006508	proteolysis
0.40	GO:0019835	cytolysis
0.38	GO:0001913	T cell mediated cytotoxicity
0.36	GO:0043068	positive regulation of programmed cell death
0.35	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
0.35	GO:0010940	positive regulation of necrotic cell death
0.35	GO:0060544	regulation of necroptotic process
0.35	GO:1903749	positive regulation of establishment of protein localization to mitochondrion

0.69	GO:0004252	serine-type endopeptidase activity
0.35	GO:0005515	protein binding

0.62	GO:0030141	secretory granule
0.38	GO:0044194	cytolytic granule
0.35	GO:0005576	extracellular region
0.35	GO:0001772	immunological synapse
0.35	GO:0005829	cytosol
0.34	GO:0005769	early endosome
0.33	GO:0005634	nucleus
0.33	GO:0005739	mitochondrion

0.69

GO:0004252

sp|P20719|HXA5_HUMAN
Homeobox protein Hox-A5
Search

HOXA5

0.96	Homeobox protein Hox-A5

0.69	GO:0007275	multicellular organism development
0.58	GO:0002069	columnar/cuboidal epithelial cell maturation
0.58	GO:0010870	positive regulation of receptor biosynthetic process
0.58	GO:0045647	negative regulation of erythrocyte differentiation
0.58	GO:0060638	mesenchymal-epithelial cell signaling
0.57	GO:0003016	respiratory system process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:0033599	regulation of mammary gland epithelial cell proliferation
0.56	GO:0010468	regulation of gene expression

0.64	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.56	GO:0001012	RNA polymerase II regulatory region DNA binding
0.53	GO:0003690	double-stranded DNA binding
0.48	GO:0035326	enhancer binding
0.35	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.43	GO:0005829	cytosol
0.42	GO:0043233	organelle lumen
0.40	GO:0043232	intracellular non-membrane-bounded organelle
0.39	GO:0044446	intracellular organelle part

sp|P20742|PZP_HUMAN
Pregnancy zone protein
Search

A2M

0.64	Alpha-macroglobulin

0.75	GO:0010951	negative regulation of endopeptidase activity
0.53	GO:0001869	negative regulation of complement activation, lectin pathway
0.44	GO:0007565	female pregnancy
0.41	GO:0032502	developmental process
0.37	GO:0006953	acute-phase response
0.36	GO:0009611	response to wounding
0.36	GO:0002576	platelet degranulation
0.36	GO:0022617	extracellular matrix disassembly
0.36	GO:0002438	acute inflammatory response to antigenic stimulus
0.35	GO:0010037	response to carbon dioxide

0.76	GO:0004866	endopeptidase inhibitor activity
0.53	GO:0043120	tumor necrosis factor binding
0.53	GO:0019959	interleukin-8 binding
0.52	GO:0019966	interleukin-1 binding
0.50	GO:0048306	calcium-dependent protein binding
0.49	GO:0002020	protease binding
0.45	GO:0005102	receptor binding
0.39	GO:0048403	brain-derived neurotrophic factor binding
0.39	GO:0048406	nerve growth factor binding
0.35	GO:0032403	protein complex binding

0.73	GO:0005615	extracellular space
0.39	GO:1903561	extracellular vesicle
0.36	GO:0031093	platelet alpha granule lumen
0.34	GO:0005829	cytosol
0.32	GO:0019866	organelle inner membrane
0.32	GO:0031966	mitochondrial membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P20749|BCL3_HUMAN
B-cell lymphoma 3 protein
Search

BCL3

0.97	B-cell chronic lymphatic leukemia protein 3

0.73	GO:0002268	follicular dendritic cell differentiation
0.72	GO:0045082	positive regulation of interleukin-10 biosynthetic process
0.72	GO:0045415	negative regulation of interleukin-8 biosynthetic process
0.72	GO:0045064	T-helper 2 cell differentiation
0.71	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process
0.70	GO:0002467	germinal center formation
0.70	GO:0002315	marginal zone B cell differentiation
0.70	GO:0042345	regulation of NF-kappaB import into nucleus
0.70	GO:0000060	protein import into nucleus, translocation
0.70	GO:0010225	response to UV-C

0.60	GO:0008134	transcription factor binding
0.56	GO:0003700	DNA binding transcription factor activity
0.50	GO:0003677	DNA binding
0.43	GO:0008139	nuclear localization sequence binding
0.43	GO:0031625	ubiquitin protein ligase binding
0.41	GO:0042802	identical protein binding
0.39	GO:0001067	regulatory region nucleic acid binding
0.38	GO:0030674	protein binding, bridging
0.38	GO:0001784	phosphotyrosine residue binding
0.37	GO:0003682	chromatin binding

0.74	GO:0032996	Bcl3-Bcl10 complex
0.73	GO:0033257	Bcl3/NF-kappaB2 complex
0.65	GO:0030496	midbody
0.58	GO:0005634	nucleus
0.58	GO:0005829	cytosol
0.55	GO:0070013	intracellular organelle lumen
0.48	GO:0044446	intracellular organelle part
0.48	GO:0005886	plasma membrane
0.41	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0000151	ubiquitin ligase complex

0.34	EC:3.1.4.2	GO:0047389
0.36	KEGG:R03876	GO:0004842

sp|P20774|MIME_HUMAN
Mimecan
Search

OGN

0.97	Osteoglycin OG

0.60	GO:0007409	axonogenesis
0.48	GO:0010469	regulation of receptor activity
0.43	GO:0048662	negative regulation of smooth muscle cell proliferation
0.41	GO:0042340	keratan sulfate catabolic process
0.41	GO:0018146	keratan sulfate biosynthetic process
0.35	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity
0.34	GO:0006418	tRNA aminoacylation for protein translation

0.49	GO:0008083	growth factor activity
0.35	GO:0002161	aminoacyl-tRNA editing activity
0.34	GO:0000049	tRNA binding
0.34	GO:0016875	ligase activity, forming carbon-oxygen bonds
0.33	GO:0046872	metal ion binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.73	GO:0031012	extracellular matrix
0.72	GO:0005615	extracellular space
0.42	GO:1903561	extracellular vesicle
0.40	GO:0043202	lysosomal lumen
0.40	GO:0005796	Golgi lumen
0.37	GO:0005783	endoplasmic reticulum
0.30	GO:0031224	intrinsic component of membrane

0.34

EC:6.1

GO:0016875

sp|P20783|NTF3_HUMAN
Neurotrophin-3
Search

NTF3

0.62	Neurotrophin-3

0.75	GO:0010469	regulation of receptor activity
0.55	GO:0050930	induction of positive chemotaxis
0.55	GO:2000251	positive regulation of actin cytoskeleton reorganization
0.55	GO:0032148	activation of protein kinase B activity
0.55	GO:0002092	positive regulation of receptor internalization
0.54	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
0.54	GO:0050918	positive chemotaxis
0.53	GO:0033138	positive regulation of peptidyl-serine phosphorylation
0.53	GO:0090630	activation of GTPase activity
0.53	GO:0000187	activation of MAPK activity

0.85	GO:0005165	neurotrophin receptor binding
0.78	GO:0008083	growth factor activity
0.55	GO:0042056	chemoattractant activity
0.35	GO:0048406	nerve growth factor binding

0.41	GO:0031410	cytoplasmic vesicle
0.40	GO:0005576	extracellular region
0.34	GO:0005788	endoplasmic reticulum lumen
0.30	GO:0016021	integral component of membrane

sp|P20794|MAK_HUMAN
Serine/threonine-protein kinase MAK
Search

MAK

0.86	Male germ cell associated kinase

0.65	GO:0046777	protein autophosphorylation
0.56	GO:0042073	intraciliary transport
0.53	GO:0060271	cilium assembly
0.49	GO:0060255	regulation of macromolecule metabolic process
0.48	GO:0080090	regulation of primary metabolic process
0.48	GO:0031323	regulation of cellular metabolic process
0.48	GO:0009889	regulation of biosynthetic process
0.48	GO:0051171	regulation of nitrogen compound metabolic process
0.46	GO:0035556	intracellular signal transduction

0.64	GO:0004672	protein kinase activity
0.63	GO:0003713	transcription coactivator activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.69	GO:0001917	photoreceptor inner segment
0.66	GO:0030496	midbody
0.65	GO:0072686	mitotic spindle
0.63	GO:0005813	centrosome
0.53	GO:0005634	nucleus
0.52	GO:0005929	cilium
0.39	GO:0005737	cytoplasm

sp|P20800|EDN2_HUMAN
Endothelin-2
Search

EDN2

0.94	Endothelin-2

0.85	GO:0019229	regulation of vasoconstriction
0.79	GO:0042310	vasoconstriction
0.69	GO:0060584	regulation of prostaglandin-endoperoxide synthase activity
0.69	GO:0003100	regulation of systemic arterial blood pressure by endothelin
0.68	GO:0014820	tonic smooth muscle contraction
0.67	GO:0014821	phasic smooth muscle contraction
0.67	GO:0010460	positive regulation of heart rate
0.65	GO:0046457	prostanoid biosynthetic process
0.65	GO:0006693	prostaglandin metabolic process
0.64	GO:0051353	positive regulation of oxidoreductase activity

0.70	GO:0031708	endothelin B receptor binding
0.60	GO:0005179	hormone activity
0.49	GO:0031707	endothelin A receptor binding
0.44	GO:0005125	cytokine activity

0.66	GO:0005576	extracellular region
0.39	GO:0005622	intracellular
0.37	GO:0045178	basal part of cell
0.36	GO:0031982	vesicle
0.35	GO:0012505	endomembrane system
0.35	GO:0043233	organelle lumen

0.64

EC:1.97.1

GO:0051353

sp|P20807|CAN3_HUMAN
Calpain-3
Search

CAPN3

0.94	Calpain 3 transcription variant 10

0.85	GO:0045214	sarcomere organization
0.65	GO:0014718	positive regulation of satellite cell activation involved in skeletal muscle regeneration
0.63	GO:0033234	negative regulation of protein sumoylation
0.61	GO:0070315	G1 to G0 transition involved in cell differentiation
0.61	GO:0006508	proteolysis
0.60	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
0.60	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.59	GO:0071472	cellular response to salt stress
0.59	GO:0071277	cellular response to calcium ion
0.59	GO:2001015	negative regulation of skeletal muscle cell differentiation

0.82	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.69	GO:0005509	calcium ion binding
0.66	GO:0055103	ligase regulator activity
0.63	GO:0031432	titin binding
0.62	GO:0008307	structural constituent of muscle
0.58	GO:0032947	protein complex scaffold activity
0.58	GO:0031402	sodium ion binding
0.34	GO:0005102	receptor binding
0.34	GO:0019899	enzyme binding
0.34	GO:0004871	signal transducer activity

0.54	GO:0030315	T-tubule
0.53	GO:0030018	Z disc
0.51	GO:0005829	cytosol
0.47	GO:0005634	nucleus
0.46	GO:0043234	protein complex

sp|P20809|IL11_HUMAN
Interleukin-11
Search

IL11

0.97	Interleukin 11

0.84	GO:0046888	negative regulation of hormone secretion
0.82	GO:0033138	positive regulation of peptidyl-serine phosphorylation
0.80	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
0.78	GO:0008284	positive regulation of cell proliferation
0.77	GO:0043410	positive regulation of MAPK cascade
0.76	GO:0010469	regulation of receptor activity
0.72	GO:0045944	positive regulation of transcription by RNA polymerase II
0.49	GO:1903659	regulation of complement-dependent cytotoxicity
0.47	GO:2000352	negative regulation of endothelial cell apoptotic process
0.43	GO:0030219	megakaryocyte differentiation

0.88	GO:0005142	interleukin-11 receptor binding
0.81	GO:0005125	cytokine activity
0.77	GO:0008083	growth factor activity

0.48	GO:0005737	cytoplasm
0.48	GO:0005615	extracellular space

sp|P20810|ICAL_HUMAN
Calpastatin
Search

CAST

0.45	Calpastatin

0.67	GO:0010951	negative regulation of endopeptidase activity
0.56	GO:2000675	negative regulation of type B pancreatic cell apoptotic process
0.55	GO:0097341	zymogen inhibition
0.52	GO:2000116	regulation of cysteine-type endopeptidase activity

0.73	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity
0.51	GO:0045296	cadherin binding
0.30	GO:0097159	organic cyclic compound binding
0.30	GO:1901363	heterocyclic compound binding

0.60	GO:0005783	endoplasmic reticulum
0.58	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|P20813|CP2B6_HUMAN
Cytochrome P450 2B6
Search

CYP2B

0.97	Cytochrome P450 family 2 subfamily B member 6

0.53	GO:0055114	oxidation-reduction process
0.52	GO:0019373	epoxygenase P450 pathway
0.48	GO:0042738	exogenous drug catabolic process
0.45	GO:0006805	xenobiotic metabolic process
0.44	GO:0008202	steroid metabolic process
0.42	GO:0042180	cellular ketone metabolic process
0.37	GO:0014070	response to organic cyclic compound
0.36	GO:0051592	response to calcium ion
0.36	GO:0010477	response to sulfur dioxide
0.35	GO:0018933	nicotine metabolic process

0.79	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.52	GO:0008392	arachidonic acid epoxygenase activity
0.50	GO:0008395	steroid hydroxylase activity
0.37	GO:0019825	oxygen binding
0.34	GO:0004721	phosphoprotein phosphatase activity

0.41	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0031090	organelle membrane
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.79

GO:0016712

sp|P20815|CP3A5_HUMAN
Cytochrome P450 3A5
Search

0.97	Cytochrome P450 family 3 subfamily A polypeptide 4

0.53	GO:0055114	oxidation-reduction process
0.51	GO:0002933	lipid hydroxylation
0.49	GO:0009822	alkaloid catabolic process
0.48	GO:0008202	steroid metabolic process
0.45	GO:0070988	demethylation
0.43	GO:0042445	hormone metabolic process
0.42	GO:0016098	monoterpenoid metabolic process
0.42	GO:0042737	drug catabolic process
0.41	GO:0042362	fat-soluble vitamin biosynthetic process
0.41	GO:1901615	organic hydroxy compound metabolic process

0.78	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.52	GO:0008395	steroid hydroxylase activity
0.42	GO:0030343	vitamin D3 25-hydroxylase activity
0.42	GO:0034875	caffeine oxidase activity
0.42	GO:0070576	vitamin D 24-hydroxylase activity
0.40	GO:0005496	steroid binding
0.38	GO:0019899	enzyme binding
0.37	GO:0019825	oxygen binding

0.42	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0031090	organelle membrane
0.30	GO:0031224	intrinsic component of membrane

0.78

GO:0016712

sp|P20823|HNF1A_HUMAN
Hepatocyte nuclear factor 1-alpha
Search

HNF1A

0.96	Transcription factor 2 splice variant

0.73	GO:0045893	positive regulation of transcription, DNA-templated
0.64	GO:0035623	renal glucose absorption
0.61	GO:0048341	paraxial mesoderm formation
0.60	GO:0030073	insulin secretion
0.60	GO:0006699	bile acid biosynthetic process
0.60	GO:0045453	bone resorption
0.59	GO:0043691	reverse cholesterol transport
0.59	GO:0031018	endocrine pancreas development
0.59	GO:0015721	bile acid and bile salt transport
0.59	GO:0046323	glucose import

0.56	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.56	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.55	GO:0000987	proximal promoter sequence-specific DNA binding
0.53	GO:0042803	protein homodimerization activity
0.53	GO:0046982	protein heterodimerization activity
0.41	GO:0001221	transcription cofactor binding
0.41	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.36	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

0.61	GO:0005634	nucleus
0.57	GO:0001750	photoreceptor outer segment
0.53	GO:0005667	transcription factor complex
0.40	GO:0005737	cytoplasm
0.35	GO:0070013	intracellular organelle lumen
0.34	GO:0044446	intracellular organelle part

sp|P20827|EFNA1_HUMAN
Ephrin-A1
Search

0.83	GO:0048013	ephrin receptor signaling pathway
0.61	GO:0061002	negative regulation of dendritic spine morphogenesis
0.60	GO:1905247	positive regulation of aspartic-type peptidase activity
0.60	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation
0.60	GO:1902959	regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
0.60	GO:1902004	positive regulation of amyloid-beta formation
0.59	GO:0003180	aortic valve morphogenesis
0.59	GO:0014028	notochord formation
0.59	GO:0070244	negative regulation of thymocyte apoptotic process
0.59	GO:0003183	mitral valve morphogenesis

0.85

GO:0046875

ephrin receptor binding

0.57	GO:0046658	anchored component of plasma membrane
0.38	GO:0005576	extracellular region
0.36	GO:0031982	vesicle
0.34	GO:0005887	integral component of plasma membrane

sp|P20839|IMDH1_HUMAN
Inosine-5'-monophosphate dehydrogenase 1
Search

IMPDH1

0.55	Inosine-5'-monophosphate dehydrogenase

0.76	GO:0006177	GMP biosynthetic process
0.52	GO:0055114	oxidation-reduction process
0.52	GO:0046651	lymphocyte proliferation
0.46	GO:0006183	GTP biosynthetic process
0.43	GO:0048066	developmental pigmentation
0.42	GO:0001654	eye development
0.35	GO:0043312	neutrophil degranulation
0.34	GO:0009409	response to cold
0.33	GO:0032259	methylation

0.79	GO:0003938	IMP dehydrogenase activity
0.54	GO:0046872	metal ion binding
0.51	GO:1901265	nucleoside phosphate binding
0.50	GO:0036094	small molecule binding
0.40	GO:0003677	DNA binding
0.33	GO:0008168	methyltransferase activity
0.33	GO:0003723	RNA binding

0.60	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.35	GO:0031983	vesicle lumen
0.34	GO:0097708	intracellular vesicle
0.33	GO:0012505	endomembrane system
0.33	GO:0070013	intracellular organelle lumen
0.33	GO:0005576	extracellular region
0.33	GO:0044446	intracellular organelle part

0.79

EC:1.1.1.205

GO:0003938

sp|P20848|A1ATR_HUMAN
Putative alpha-1-antitrypsin-related protein
Search

SERPINA1

0.88	alpha-1-antitrypsin precursor

0.57	GO:0010951	negative regulation of endopeptidase activity
0.46	GO:0006953	acute-phase response
0.39	GO:0034097	response to cytokine
0.39	GO:0043434	response to peptide hormone
0.37	GO:0032501	multicellular organismal process
0.36	GO:0019953	sexual reproduction
0.36	GO:0006487	protein N-linked glycosylation
0.36	GO:0046687	response to chromate
0.36	GO:0033986	response to methanol
0.36	GO:0034014	response to triglyceride

0.59	GO:0004867	serine-type endopeptidase inhibitor activity
0.54	GO:0002020	protease binding
0.48	GO:0042802	identical protein binding
0.38	GO:0032190	acrosin binding
0.38	GO:0001972	retinoic acid binding
0.38	GO:0031210	phosphatidylcholine binding
0.34	GO:0008233	peptidase activity
0.34	GO:0008201	heparin binding

0.73	GO:0005615	extracellular space
0.48	GO:0005783	endoplasmic reticulum
0.47	GO:0005794	Golgi apparatus
0.40	GO:1903561	extracellular vesicle
0.39	GO:0031091	platelet alpha granule
0.39	GO:0097183	protein C inhibitor-coagulation factor XI complex
0.39	GO:0036024	protein C inhibitor-TMPRSS7 complex
0.39	GO:0097182	protein C inhibitor-coagulation factor Xa complex
0.39	GO:0097181	protein C inhibitor-coagulation factor V complex
0.39	GO:0036025	protein C inhibitor-TMPRSS11E complex

0.34

GO:0008233

sp|P20849|CO9A1_HUMAN
Collagen alpha-1(IX) chain
Search

COL9A1

0.90	Collagen type IX alpha 1 chain

0.43	GO:0003417	growth plate cartilage development
0.41	GO:0001894	tissue homeostasis
0.36	GO:0002062	chondrocyte differentiation
0.35	GO:0030198	extracellular matrix organization

0.36	GO:0030020	extracellular matrix structural constituent conferring tensile strength
0.36	GO:0046872	metal ion binding

0.77	GO:0005581	collagen trimer
0.41	GO:0005578	proteinaceous extracellular matrix
0.35	GO:0005788	endoplasmic reticulum lumen
0.30	GO:0016021	integral component of membrane

sp|P20851|C4BPB_HUMAN
C4b-binding protein beta chain
Search

C4BPB

0.97	Complement component 4 binding protein beta

0.86	GO:0045959	negative regulation of complement activation, classical pathway
0.76	GO:0045732	positive regulation of protein catabolic process
0.52	GO:0006958	complement activation, classical pathway
0.49	GO:0045087	innate immune response
0.48	GO:1903027	regulation of opsonization
0.47	GO:0006003	fructose 2,6-bisphosphate metabolic process
0.47	GO:0006000	fructose metabolic process
0.44	GO:0007596	blood coagulation
0.44	GO:0046835	carbohydrate phosphorylation

0.47	GO:0003873	6-phosphofructo-2-kinase activity
0.39	GO:0005515	protein binding
0.38	GO:0032559	adenyl ribonucleotide binding
0.38	GO:0008144	drug binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005509	calcium ion binding

0.70	GO:0005615	extracellular space
0.61	GO:0044216	other organism cell
0.37	GO:0005886	plasma membrane

0.47	EC:2.7.1.105	GO:0003873
0.47	KEGG:R02732	GO:0003873

sp|P20853|CP2A7_HUMAN
Cytochrome P450 2A7
Search

0.97	Felis catus cytochrome P450, family 2, subfamily A, polypeptide 13

0.53	GO:0055114	oxidation-reduction process
0.46	GO:0019373	epoxygenase P450 pathway

0.77	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.46	GO:0008392	arachidonic acid epoxygenase activity
0.45	GO:0008395	steroid hydroxylase activity

0.77

GO:0016712

sp|P20908|CO5A1_HUMAN
Collagen alpha-1(V) chain
Search

COL5A1

0.88	Collagen type XI alpha 1 chain

0.61	GO:0030199	collagen fibril organization
0.61	GO:0045112	integrin biosynthetic process
0.60	GO:0035989	tendon development
0.59	GO:1903225	negative regulation of endodermal cell differentiation
0.58	GO:0032964	collagen biosynthetic process
0.58	GO:0035313	wound healing, spreading of epidermal cells
0.57	GO:0090596	sensory organ morphogenesis
0.55	GO:0003007	heart morphogenesis
0.55	GO:0043588	skin development
0.53	GO:0001654	eye development

0.81	GO:0005201	extracellular matrix structural constituent
0.58	GO:0048407	platelet-derived growth factor binding
0.57	GO:0043394	proteoglycan binding
0.55	GO:0008201	heparin binding
0.36	GO:0050840	extracellular matrix binding
0.36	GO:0030674	protein binding, bridging
0.34	GO:0005178	integrin binding
0.33	GO:0046872	metal ion binding

0.74	GO:0005581	collagen trimer
0.63	GO:0098643	banded collagen fibril
0.52	GO:0005604	basement membrane
0.51	GO:0005615	extracellular space
0.37	GO:0005788	endoplasmic reticulum lumen
0.35	GO:1903561	extracellular vesicle

sp|P20916|MAG_HUMAN
Myelin-associated glycoprotein
Search

MAG

0.97	Sialic-acid binding protein-4

0.60	GO:0031643	positive regulation of myelination
0.59	GO:0022010	central nervous system myelination
0.57	GO:0010977	negative regulation of neuron projection development
0.56	GO:0043524	negative regulation of neuron apoptotic process
0.42	GO:0048711	positive regulation of astrocyte differentiation
0.41	GO:0071260	cellular response to mechanical stimulus
0.41	GO:0010771	negative regulation of cell morphogenesis involved in differentiation
0.41	GO:0030516	regulation of axon extension
0.41	GO:0048640	negative regulation of developmental growth
0.41	GO:0030308	negative regulation of cell growth

0.62	GO:1905576	ganglioside GT1b binding
0.60	GO:0033691	sialic acid binding
0.53	GO:0042802	identical protein binding
0.49	GO:0046983	protein dimerization activity
0.42	GO:0030246	carbohydrate binding
0.40	GO:0019901	protein kinase binding
0.39	GO:0005102	receptor binding
0.35	GO:0005509	calcium ion binding

0.60	GO:0043218	compact myelin
0.59	GO:0033270	paranode region of axon
0.48	GO:0005887	integral component of plasma membrane
0.44	GO:0097453	mesaxon
0.43	GO:0035749	myelin sheath adaxonal region
0.40	GO:0045121	membrane raft
0.34	GO:0005737	cytoplasm
0.34	GO:0005604	basement membrane
0.33	GO:0030054	cell junction
0.32	GO:0019013	viral nucleocapsid

sp|P20929|NEBU_HUMAN
Nebulin
Search

NEB

0.70

Nebulin

0.46	GO:0048747	muscle fiber development
0.32	GO:0045214	sarcomere organization
0.32	GO:0030832	regulation of actin filament length
0.30	GO:0006936	muscle contraction
0.30	GO:0048731	system development
0.30	GO:0006928	movement of cell or subcellular component
0.30	GO:0007525	somatic muscle development

0.74	GO:0003779	actin binding
0.30	GO:0008307	structural constituent of muscle

0.61	GO:0030018	Z disc
0.32	GO:0005865	striated muscle thin filament
0.31	GO:0043234	protein complex
0.30	GO:0005615	extracellular space
0.30	GO:0016020	membrane
0.30	GO:1903561	extracellular vesicle
0.30	GO:0005829	cytosol

sp|P20930|FILA_HUMAN
Filaggrin
Search

0.71

Filaggrin

0.52	GO:0061436	establishment of skin barrier
0.39	GO:0070268	cornification
0.39	GO:0018149	peptide cross-linking
0.37	GO:0043312	neutrophil degranulation
0.34	GO:0045109	intermediate filament organization
0.33	GO:0050936	xanthophore differentiation
0.33	GO:0021529	spinal cord oligodendrocyte cell differentiation
0.33	GO:0030318	melanocyte differentiation
0.33	GO:0014032	neural crest cell development
0.33	GO:0048701	embryonic cranial skeleton morphogenesis

0.66	GO:0005509	calcium ion binding
0.57	GO:0005198	structural molecule activity
0.55	GO:0046914	transition metal ion binding
0.36	GO:0005515	protein binding
0.34	GO:0044877	macromolecular complex binding
0.32	GO:0016301	kinase activity
0.31	GO:0016787	hydrolase activity

0.43	GO:0001533	cornified envelope
0.42	GO:0036457	keratohyalin granule
0.38	GO:1904724	tertiary granule lumen
0.38	GO:0005882	intermediate filament
0.37	GO:0070062	extracellular exosome
0.37	GO:0005634	nucleus
0.36	GO:0005829	cytosol
0.32	GO:0000428	DNA-directed RNA polymerase complex
0.32	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

0.31

GO:0016787

sp|P20933|ASPG_HUMAN
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Search

AGA

0.75	Aspartylglucosaminidase

0.60	GO:0006517	protein deglycosylation
0.49	GO:0051604	protein maturation
0.38	GO:0006508	proteolysis
0.36	GO:0043312	neutrophil degranulation
0.34	GO:0035235	ionotropic glutamate receptor signaling pathway

0.63	GO:0003948	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
0.40	GO:0043621	protein self-association
0.38	GO:0008233	peptidase activity
0.34	GO:0004970	ionotropic glutamate receptor activity

0.56	GO:0005764	lysosome
0.52	GO:0005615	extracellular space
0.50	GO:0005783	endoplasmic reticulum
0.37	GO:1903561	extracellular vesicle
0.36	GO:0034774	secretory granule lumen
0.36	GO:0005775	vacuolar lumen
0.32	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.63	EC:3.5.1.26	GO:0003948
0.63	KEGG:R03421	GO:0003948

sp|P20936|RASA1_HUMAN
Ras GTPase-activating protein 1
Search

RASA1

0.95	Ras GTPase-activating protein 1

0.83	GO:0046580	negative regulation of Ras protein signal transduction
0.74	GO:0043547	positive regulation of GTPase activity
0.60	GO:0007165	signal transduction
0.57	GO:0001953	negative regulation of cell-matrix adhesion
0.57	GO:0001568	blood vessel development
0.53	GO:0043066	negative regulation of apoptotic process
0.53	GO:0030833	regulation of actin filament polymerization
0.50	GO:0009653	anatomical structure morphogenesis
0.40	GO:1901215	negative regulation of neuron death
0.40	GO:0043523	regulation of neuron apoptotic process

0.75	GO:0005096	GTPase activator activity
0.56	GO:0001784	phosphotyrosine residue binding
0.51	GO:0051020	GTPase binding
0.50	GO:0005102	receptor binding
0.36	GO:0019870	potassium channel inhibitor activity
0.36	GO:0043422	protein kinase B binding
0.35	GO:1990782	protein tyrosine kinase binding
0.35	GO:0044325	ion channel binding
0.34	GO:0032403	protein complex binding
0.34	GO:0008134	transcription factor binding

0.54	GO:0001726	ruffle
0.48	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane
0.37	GO:0005737	cytoplasm
0.35	GO:0031965	nuclear membrane

sp|P20941|PHOS_HUMAN
Phosducin
Search

PDC

0.73	Phosducin b

0.57	GO:0008616	queuosine biosynthetic process
0.52	GO:0007601	visual perception
0.42	GO:0050896	response to stimulus
0.38	GO:0043086	negative regulation of catalytic activity
0.36	GO:0023052	signaling
0.36	GO:0007154	cell communication
0.34	GO:0050789	regulation of biological process

0.61	GO:0008479	queuine tRNA-ribosyltransferase activity
0.41	GO:0004859	phospholipase inhibitor activity

0.84	GO:0001750	photoreceptor outer segment
0.56	GO:0001917	photoreceptor inner segment
0.47	GO:0005829	cytosol
0.44	GO:0005634	nucleus

0.61

EC:2.4.2.29

GO:0008479

sp|P20962|PTMS_HUMAN
Parathymosin
Search

PTMA

0.94	Prothymosin alpha

0.51	GO:0002376	immune system process
0.44	GO:0043486	histone exchange
0.44	GO:0045905	positive regulation of translational termination
0.44	GO:0045901	positive regulation of translational elongation
0.44	GO:0006452	translational frameshifting
0.43	GO:0007268	chemical synaptic transmission
0.41	GO:0050790	regulation of catalytic activity
0.40	GO:0044092	negative regulation of molecular function
0.40	GO:0006259	DNA metabolic process
0.40	GO:0035556	intracellular signal transduction

0.45	GO:0019992	diacylglycerol binding
0.44	GO:0033613	activating transcription factor binding
0.43	GO:0042393	histone binding
0.42	GO:0005509	calcium ion binding
0.42	GO:0005543	phospholipid binding
0.42	GO:0008270	zinc ion binding
0.42	GO:0008135	translation factor activity, RNA binding
0.41	GO:0004857	enzyme inhibitor activity
0.41	GO:0043022	ribosome binding
0.38	GO:0004709	MAP kinase kinase kinase activity

0.50	GO:0005829	cytosol
0.47	GO:0005634	nucleus
0.47	GO:0043233	organelle lumen
0.42	GO:0044446	intracellular organelle part
0.38	GO:0070062	extracellular exosome
0.37	GO:0005694	chromosome
0.36	GO:0000428	DNA-directed RNA polymerase complex
0.36	GO:0005667	transcription factor complex
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.38

EC:2.7.11 EC:2.7.11.25

GO:0004709

sp|P20963|CD3Z_HUMAN
T-cell surface glycoprotein CD3 zeta chain
Search

CD247

0.97	T-cell surface glycoprotein CD3 zeta chain

0.71	GO:0007166	cell surface receptor signaling pathway
0.50	GO:0002757	immune response-activating signal transduction
0.50	GO:0070207	protein homotrimerization
0.49	GO:0051289	protein homotetramerization
0.46	GO:0002250	adaptive immune response
0.38	GO:0031295	T cell costimulation
0.38	GO:0006909	phagocytosis
0.37	GO:0002252	immune effector process
0.36	GO:0050690	regulation of defense response to virus by virus

0.70	GO:0004888	transmembrane signaling receptor activity
0.49	GO:1990782	protein tyrosine kinase binding
0.46	GO:0042802	identical protein binding
0.43	GO:0046983	protein dimerization activity

0.54	GO:0042105	alpha-beta T cell receptor complex
0.37	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|P21108|PRPS3_HUMAN
Ribose-phosphate pyrophosphokinase 3
Search

PRPS1

0.88	Phosphoribosyl pyrophosphate synthetase 1

0.66	GO:0009116	nucleoside metabolic process
0.64	GO:0009165	nucleotide biosynthetic process
0.63	GO:0009156	ribonucleoside monophosphate biosynthetic process
0.61	GO:0034418	urate biosynthetic process
0.56	GO:0046101	hypoxanthine biosynthetic process
0.51	GO:0007399	nervous system development
0.45	GO:0006163	purine nucleotide metabolic process
0.37	GO:0008584	male gonad development
0.36	GO:0016310	phosphorylation

0.78	GO:0004749	ribose phosphate diphosphokinase activity
0.64	GO:0000287	magnesium ion binding
0.53	GO:0042802	identical protein binding
0.48	GO:0046983	protein dimerization activity
0.42	GO:0032559	adenyl ribonucleotide binding
0.42	GO:0008144	drug binding
0.42	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0016301	kinase activity

0.78	EC:2.7.6.1	GO:0004749
0.78	KEGG:R01049	GO:0004749

sp|P21127|CD11B_HUMAN
Cyclin-dependent kinase 11B
Search

0.86	Cyclin-dependent kinase 11B

0.63	GO:0006468	protein phosphorylation
0.49	GO:2001234	negative regulation of apoptotic signaling pathway
0.49	GO:0007346	regulation of mitotic cell cycle
0.48	GO:0001824	blastocyst development
0.47	GO:0051783	regulation of nuclear division
0.46	GO:0010564	regulation of cell cycle process
0.42	GO:0007224	smoothened signaling pathway
0.38	GO:0060255	regulation of macromolecule metabolic process
0.36	GO:0001558	regulation of cell growth
0.36	GO:0051301	cell division

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0060089	molecular transducer activity
0.34	GO:0005515	protein binding
0.33	GO:0003723	RNA binding

0.43	GO:0005634	nucleus
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|P21128|ENDOU_HUMAN
Poly(U)-specific endoribonuclease
Search

ENDOU

0.91	Endonuclease, polyU-specific

0.70	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.68	GO:0006955	immune response
0.67	GO:0006898	receptor-mediated endocytosis
0.57	GO:0007565	female pregnancy
0.46	GO:0006508	proteolysis
0.35	GO:0010469	regulation of receptor activity
0.33	GO:0007034	vacuolar transport
0.32	GO:0030001	metal ion transport
0.31	GO:0043043	peptide biosynthetic process
0.31	GO:0055085	transmembrane transport

0.74	GO:0005044	scavenger receptor activity
0.72	GO:0001871	pattern binding
0.71	GO:0004521	endoribonuclease activity
0.65	GO:0030246	carbohydrate binding
0.49	GO:0017171	serine hydrolase activity
0.47	GO:0070011	peptidase activity, acting on L-amino acid peptides
0.45	GO:0003723	RNA binding
0.36	GO:0008083	growth factor activity
0.35	GO:0046872	metal ion binding
0.32	GO:0042626	ATPase activity, coupled to transmembrane movement of substances

0.40	GO:0005737	cytoplasm
0.37	GO:0005576	extracellular region
0.33	GO:0005886	plasma membrane
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.31	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

sp|P21145|MAL_HUMAN
Myelin and lymphocyte protein
Search

MAL

0.96	myelin and lymphocyte protein isoform X1

0.57	GO:0001766	membrane raft polarization
0.54	GO:0045056	transcytosis
0.54	GO:0042552	myelination
0.52	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
0.45	GO:0008104	protein localization
0.35	GO:0007417	central nervous system development
0.35	GO:0006915	apoptotic process
0.34	GO:0030154	cell differentiation
0.34	GO:0046907	intracellular transport
0.34	GO:0070727	cellular macromolecule localization

0.65	GO:0019911	structural constituent of myelin sheath
0.36	GO:0016505	peptidase activator activity involved in apoptotic process
0.34	GO:0008289	lipid binding
0.34	GO:0005515	protein binding

0.65	GO:0045121	membrane raft
0.49	GO:0005783	endoplasmic reticulum
0.40	GO:0016324	apical plasma membrane
0.36	GO:0019898	extrinsic component of membrane
0.34	GO:0000139	Golgi membrane
0.34	GO:0070062	extracellular exosome
0.33	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0016021	integral component of membrane

sp|P21217|FUT3_HUMAN
Galactoside 3(4)-L-fucosyltransferase
Search

0.63	Lewis alpha-3-fucosyltransferase

0.81	GO:0036065	fucosylation
0.74	GO:0006486	protein glycosylation
0.44	GO:0006672	ceramide metabolic process
0.40	GO:0042355	L-fucose catabolic process
0.39	GO:0009312	oligosaccharide biosynthetic process
0.36	GO:0009988	cell-cell recognition

0.81

GO:0008417

fucosyltransferase activity

0.81	GO:0032580	Golgi cisterna membrane
0.39	GO:0009986	cell surface
0.37	GO:0070062	extracellular exosome
0.35	GO:0071944	cell periphery
0.30	GO:0016021	integral component of membrane

0.81

GO:0008417

sp|P21246|PTN_HUMAN
Pleiotrophin
Search

PTN

0.97	Pleiotrophin

0.76	GO:0010469	regulation of receptor activity
0.55	GO:0030282	bone mineralization
0.54	GO:0007611	learning or memory
0.53	GO:0008284	positive regulation of cell proliferation
0.44	GO:0007399	nervous system development
0.42	GO:0051781	positive regulation of cell division
0.42	GO:1904391	response to ciliary neurotrophic factor
0.41	GO:1904373	response to kainic acid
0.41	GO:1904395	positive regulation of skeletal muscle acetylcholine-gated channel clustering
0.41	GO:0060322	head development

0.78	GO:0008083	growth factor activity
0.59	GO:0035374	chondroitin sulfate binding
0.55	GO:0008201	heparin binding
0.51	GO:0019901	protein kinase binding
0.42	GO:1904399	heparan sulfate binding
0.41	GO:0035373	chondroitin sulfate proteoglycan binding
0.41	GO:0038085	vascular endothelial growth factor binding
0.35	GO:0004864	protein phosphatase inhibitor activity
0.32	GO:0016301	kinase activity

0.50	GO:0005615	extracellular space
0.48	GO:0005783	endoplasmic reticulum
0.43	GO:0043234	protein complex
0.39	GO:0031594	neuromuscular junction
0.39	GO:0005604	basement membrane
0.38	GO:0048471	perinuclear region of cytoplasm
0.38	GO:0009986	cell surface
0.30	GO:0016020	membrane

sp|P21266|GSTM3_HUMAN
Glutathione S-transferase Mu 3
Search

GSTM3

0.44	Glutathione S-transferase

0.60	GO:0018916	nitrobenzene metabolic process
0.57	GO:0070458	cellular detoxification of nitrogen compound
0.53	GO:0043627	response to estrogen
0.53	GO:0006749	glutathione metabolic process
0.53	GO:0042178	xenobiotic catabolic process
0.38	GO:1901687	glutathione derivative biosynthetic process
0.36	GO:0008065	establishment of blood-nerve barrier

0.78	GO:0004364	glutathione transferase activity
0.57	GO:0043295	glutathione binding
0.53	GO:0042802	identical protein binding
0.50	GO:0019899	enzyme binding
0.49	GO:0046983	protein dimerization activity
0.34	GO:0016223	beta-alanine-pyruvate transaminase activity

0.58	GO:0045171	intercellular bridge
0.56	GO:0035686	sperm fibrous sheath
0.50	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.78

EC:2.5.1.18

GO:0004364

sp|P21281|VATB2_HUMAN
V-type proton ATPase subunit B, brain isoform
Search

ATP6V1B2

0.95	V-type ATPase beta subunit

0.75	GO:0015991	ATP hydrolysis coupled proton transport
0.61	GO:0046034	ATP metabolic process
0.43	GO:0045851	pH reduction
0.42	GO:0007588	excretion
0.41	GO:0042472	inner ear morphogenesis
0.41	GO:0001503	ossification
0.41	GO:0007605	sensory perception of sound
0.40	GO:0055074	calcium ion homeostasis
0.37	GO:0051453	regulation of intracellular pH
0.37	GO:0033572	transferrin transport

0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0015078	hydrogen ion transmembrane transporter activity
0.35	GO:0016787	hydrolase activity
0.34	GO:0005515	protein binding
0.33	GO:0022853	active ion transmembrane transporter activity
0.33	GO:0044877	macromolecular complex binding
0.33	GO:0015399	primary active transmembrane transporter activity

0.79	GO:0033180	proton-transporting V-type ATPase, V1 domain
0.54	GO:0005902	microvillus
0.50	GO:0001726	ruffle
0.50	GO:0043209	myelin sheath
0.47	GO:0005829	cytosol
0.42	GO:0043227	membrane-bounded organelle
0.41	GO:0005886	plasma membrane
0.41	GO:0043229	intracellular organelle
0.40	GO:0045177	apical part of cell
0.40	GO:0098805	whole membrane

0.35

GO:0016787

sp|P21283|VATC1_HUMAN
V-type proton ATPase subunit C 1
Search

ATP6V1C1

0.67	V-type proton ATPase subunit C

0.75	GO:0015991	ATP hydrolysis coupled proton transport
0.35	GO:0090383	phagosome acidification
0.35	GO:0033572	transferrin transport
0.35	GO:0008286	insulin receptor signaling pathway
0.35	GO:0016241	regulation of macroautophagy

0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.55	GO:0036442	proton-exporting ATPase activity
0.53	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
0.44	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
0.33	GO:0005515	protein binding

0.80	GO:0033180	proton-transporting V-type ATPase, V1 domain
0.48	GO:0005765	lysosomal membrane
0.47	GO:0016471	vacuolar proton-transporting V-type ATPase complex
0.42	GO:0005886	plasma membrane
0.38	GO:0045177	apical part of cell
0.37	GO:0031410	cytoplasmic vesicle
0.36	GO:0070062	extracellular exosome
0.33	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

sp|P21291|CSRP1_HUMAN
Cysteine and glycine-rich protein 1
Search

CSRP1

0.97	Cysteine and glycine-rich protein 1

0.39	GO:0031102	neuron projection regeneration
0.38	GO:0060027	convergent extension involved in gastrulation
0.38	GO:0042074	cell migration involved in gastrulation
0.38	GO:0007254	JNK cascade
0.38	GO:0003007	heart morphogenesis
0.37	GO:0016055	Wnt signaling pathway
0.37	GO:0070527	platelet aggregation
0.34	GO:0006937	regulation of muscle contraction
0.34	GO:0030036	actin cytoskeleton organization

0.54	GO:0046872	metal ion binding
0.35	GO:0051393	alpha-actinin binding
0.34	GO:0051219	phosphoprotein binding
0.34	GO:0003723	RNA binding

0.53	GO:0097517	contractile actin filament bundle
0.52	GO:0042641	actomyosin
0.52	GO:0005925	focal adhesion
0.51	GO:0031252	cell leading edge
0.45	GO:0005634	nucleus
0.38	GO:0005737	cytoplasm
0.36	GO:0070062	extracellular exosome
0.34	GO:0099512	supramolecular fiber
0.33	GO:0031974	membrane-enclosed lumen
0.33	GO:0043234	protein complex

sp|P21333|FLNA_HUMAN
Filamin-A
Search

FLNA

0.53

Filamin A

0.43	GO:2001046	positive regulation of integrin-mediated signaling pathway
0.43	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
0.43	GO:0051764	actin crosslink formation
0.43	GO:0016479	negative regulation of transcription by RNA polymerase I
0.43	GO:0034394	protein localization to cell surface
0.42	GO:0090505	epiboly involved in wound healing
0.42	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
0.42	GO:0051220	cytoplasmic sequestering of protein
0.42	GO:0042993	positive regulation of transcription factor import into nucleus
0.42	GO:0043113	receptor clustering

0.78	GO:0051015	actin filament binding
0.44	GO:0034988	Fc-gamma receptor I complex binding
0.43	GO:0017160	Ral GTPase binding
0.42	GO:0015459	potassium channel regulator activity
0.42	GO:0048365	Rac GTPase binding
0.42	GO:0044325	ion channel binding
0.41	GO:0045296	cadherin binding
0.41	GO:0001664	G-protein coupled receptor binding
0.40	GO:0019900	kinase binding
0.40	GO:0042803	protein homodimerization activity

0.44	GO:0098723	skeletal muscle myofibril
0.43	GO:0042383	sarcolemma
0.43	GO:0031523	Myb complex
0.43	GO:0030486	smooth muscle dense body
0.43	GO:0030018	Z disc
0.42	GO:0097433	dense body
0.42	GO:0031941	filamentous actin
0.42	GO:0031430	M band
0.42	GO:0005829	cytosol
0.40	GO:0005911	cell-cell junction

sp|P21359|NF1_HUMAN
Neurofibromin
Search

NF1

0.85	Neurofibromatosis type 1

0.75	GO:0043087	regulation of GTPase activity
0.60	GO:0007165	signal transduction
0.55	GO:0043409	negative regulation of MAPK cascade
0.55	GO:0050890	cognition
0.55	GO:0045685	regulation of glial cell differentiation
0.54	GO:0061535	glutamate secretion, neurotransmission
0.54	GO:0061534	gamma-aminobutyric acid secretion, neurotransmission
0.54	GO:0001937	negative regulation of endothelial cell proliferation
0.54	GO:0021897	forebrain astrocyte development
0.53	GO:0043535	regulation of blood vessel endothelial cell migration

0.55	GO:0031210	phosphatidylcholine binding
0.54	GO:0008429	phosphatidylethanolamine binding
0.51	GO:0005096	GTPase activator activity
0.35	GO:0008017	microtubule binding
0.34	GO:0045545	syndecan binding

0.51	GO:0030425	dendrite
0.51	GO:0030424	axon
0.48	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane
0.48	GO:0098793	presynapse
0.38	GO:0005737	cytoplasm
0.37	GO:0005730	nucleolus
0.34	GO:0014069	postsynaptic density
0.32	GO:0043234	protein complex

sp|P21397|AOFA_HUMAN
Amine oxidase [flavin-containing] A
Search

MAOA

0.48	Amine oxidase [flavin-containing] A

0.55	GO:0042420	dopamine catabolic process
0.52	GO:0055114	oxidation-reduction process
0.42	GO:0042135	neurotransmitter catabolic process
0.38	GO:0014063	negative regulation of serotonin secretion
0.38	GO:0010269	response to selenium ion
0.38	GO:0045915	positive regulation of catecholamine metabolic process
0.38	GO:0051412	response to corticosterone
0.38	GO:0010044	response to aluminum ion
0.38	GO:0042053	regulation of dopamine metabolic process
0.37	GO:0045471	response to ethanol

0.54	GO:0016491	oxidoreductase activity
0.36	GO:0042803	protein homodimerization activity
0.36	GO:0050660	flavin adenine dinucleotide binding
0.35	GO:0051378	serotonin binding

0.48	GO:0005739	mitochondrion
0.45	GO:0031967	organelle envelope
0.45	GO:0031090	organelle membrane
0.43	GO:0098805	whole membrane
0.41	GO:0019867	outer membrane
0.36	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.54

GO:0016491

sp|P21399|ACOC_HUMAN
Cytoplasmic aconitate hydratase
Search

ACO1

0.92	Cytoplasmic aconitate hydratase

0.86	GO:0010040	response to iron(II) ion
0.76	GO:0006879	cellular iron ion homeostasis
0.50	GO:0050892	intestinal absorption
0.46	GO:0009791	post-embryonic development
0.46	GO:0006101	citrate metabolic process
0.44	GO:0006417	regulation of translation
0.41	GO:0009060	aerobic respiration
0.37	GO:0001889	liver development
0.30	GO:0044238	primary metabolic process

0.79	GO:0003994	aconitate hydratase activity
0.67	GO:0051539	4 iron, 4 sulfur cluster binding
0.53	GO:0030350	iron-responsive element binding
0.48	GO:0051538	3 iron, 4 sulfur cluster binding
0.38	GO:0046872	metal ion binding
0.37	GO:0048027	mRNA 5'-UTR binding
0.35	GO:0005515	protein binding

0.49	GO:0005737	cytoplasm
0.43	GO:0012505	endomembrane system
0.39	GO:0070062	extracellular exosome
0.39	GO:0043231	intracellular membrane-bounded organelle

0.79

EC:4.2.1.3

GO:0003994

sp|P21439|MDR3_HUMAN
Phosphatidylcholine translocator ABCB4
Search

0.53	Multi-drug resistance protein 1 transcript variant 2

0.59	GO:1903793	positive regulation of anion transport
0.56	GO:0099040	ceramide translocation
0.56	GO:0045332	phospholipid translocation
0.55	GO:1901557	response to fenofibrate
0.55	GO:1903413	cellular response to bile acid
0.55	GO:0055085	transmembrane transport
0.53	GO:0032782	bile acid secretion
0.53	GO:0061091	regulation of phospholipid translocation
0.52	GO:0032376	positive regulation of cholesterol transport
0.52	GO:2001225	regulation of chloride transport

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.63	GO:0090554	phosphatidylcholine-translocating ATPase activity
0.56	GO:0099038	ceramide-translocating ATPase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0090555	phosphatidylethanolamine-translocating ATPase activity
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.46	GO:0042910	xenobiotic transmembrane transporter activity
0.43	GO:0015238	drug transmembrane transporter activity

0.57	GO:0016324	apical plasma membrane
0.55	GO:0046581	intercellular canaliculus
0.48	GO:0005925	focal adhesion
0.46	GO:0009986	cell surface
0.45	GO:0015629	actin cytoskeleton
0.44	GO:0005654	nucleoplasm
0.44	GO:0005829	cytosol
0.42	GO:0031526	brush border membrane
0.42	GO:0070062	extracellular exosome
0.40	GO:0098857	membrane microdomain

sp|P21452|NK2R_HUMAN
Substance-K receptor
Search

TACR2

0.94	Neuromedin-K receptor

0.85	GO:0007217	tachykinin receptor signaling pathway
0.65	GO:1902093	positive regulation of flagellated sperm motility
0.61	GO:0070472	regulation of uterine smooth muscle contraction
0.49	GO:0045987	positive regulation of smooth muscle contraction
0.44	GO:0007267	cell-cell signaling
0.43	GO:0035106	operant conditioning
0.42	GO:0033685	negative regulation of luteinizing hormone secretion
0.42	GO:0032224	positive regulation of synaptic transmission, cholinergic
0.42	GO:0043117	positive regulation of vascular permeability
0.42	GO:0014827	intestine smooth muscle contraction

0.86	GO:0004995	tachykinin receptor activity
0.34	GO:0050254	rhodopsin kinase activity
0.34	GO:0005515	protein binding

0.64	GO:0097225	sperm midpiece
0.60	GO:0061827	sperm head
0.56	GO:0005886	plasma membrane
0.37	GO:0030425	dendrite
0.37	GO:0044297	cell body
0.36	GO:0031252	cell leading edge
0.34	GO:0005634	nucleus
0.33	GO:0009986	cell surface
0.33	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.34

EC:2.7.11.14

GO:0050254

sp|P21453|S1PR1_HUMAN
Sphingosine 1-phosphate receptor 1
Search

S1PR1

0.93	Endothelial differentiation, sphingolipid G-protein-coupled receptor, 1

0.85	GO:0003376	sphingosine-1-phosphate signaling pathway
0.56	GO:0003245	cardiac muscle tissue growth involved in heart morphogenesis
0.54	GO:0001955	blood vessel maturation
0.54	GO:0072678	T cell migration
0.53	GO:0045124	regulation of bone resorption
0.53	GO:0061384	heart trabecula morphogenesis
0.53	GO:0030032	lamellipodium assembly
0.52	GO:0030500	regulation of bone mineralization
0.52	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.52	GO:0030595	leukocyte chemotaxis

0.86	GO:0038036	sphingosine-1-phosphate receptor activity
0.51	GO:0001664	G-protein coupled receptor binding
0.38	GO:0046625	sphingolipid binding

0.51	GO:0009897	external side of plasma membrane
0.47	GO:0005654	nucleoplasm
0.45	GO:0031226	intrinsic component of plasma membrane
0.38	GO:0045121	membrane raft
0.37	GO:0005768	endosome
0.34	GO:0098590	plasma membrane region
0.30	GO:0016021	integral component of membrane

sp|P21462|FPR1_HUMAN
fMet-Leu-Phe receptor
Search

0.96	Formyl peptide receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.55	GO:0002430	complement receptor mediated signaling pathway
0.52	GO:0050900	leukocyte migration
0.52	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.52	GO:0060326	cell chemotaxis
0.51	GO:0006954	inflammatory response
0.48	GO:1904646	cellular response to amyloid-beta
0.48	GO:0090026	positive regulation of monocyte chemotaxis
0.47	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.46	GO:0019722	calcium-mediated signaling

0.85	GO:0004982	N-formyl peptide receptor activity
0.55	GO:0004875	complement receptor activity
0.51	GO:0005124	scavenger receptor binding
0.39	GO:0050786	RAGE receptor binding
0.36	GO:0038024	cargo receptor activity
0.35	GO:0016494	C-X-C chemokine receptor activity

0.45	GO:0005887	integral component of plasma membrane
0.38	GO:0101003	ficolin-1-rich granule membrane
0.36	GO:0035577	azurophil granule membrane
0.35	GO:0035579	specific granule membrane
0.35	GO:0070821	tertiary granule membrane
0.33	GO:0009897	external side of plasma membrane

sp|P21506|ZNF10_HUMAN
Zinc finger protein 10
Search

0.58	Zinc finger protein 10

0.54	GO:1903506	regulation of nucleic acid-templated transcription
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.43	GO:1902679	negative regulation of RNA biosynthetic process
0.39	GO:1902680	positive regulation of RNA biosynthetic process
0.36	GO:0006351	transcription, DNA-templated
0.35	GO:0007186	G-protein coupled receptor signaling pathway
0.35	GO:0060669	embryonic placenta morphogenesis
0.34	GO:0043043	peptide biosynthetic process
0.33	GO:0044267	cellular protein metabolic process

0.51	GO:0003676	nucleic acid binding
0.49	GO:0046872	metal ion binding
0.46	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.35	GO:0004930	G-protein coupled receptor activity
0.34	GO:0003735	structural constituent of ribosome
0.34	GO:0005515	protein binding

0.45	GO:0017053	transcriptional repressor complex
0.44	GO:0016604	nuclear body
0.37	GO:0016363	nuclear matrix
0.34	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

sp|P21549|SPYA_HUMAN
Serine--pyruvate aminotransferase
Search

AGXT

0.84	Serine--pyruvate aminotransferase

0.62	GO:0019265	glycine biosynthetic process, by transamination of glyoxylate
0.60	GO:0046724	oxalic acid secretion
0.60	GO:0019448	L-cysteine catabolic process
0.55	GO:0009436	glyoxylate catabolic process
0.54	GO:0007219	Notch signaling pathway
0.53	GO:0042853	L-alanine catabolic process
0.43	GO:0071391	cellular response to estrogen stimulus
0.39	GO:0051591	response to cAMP
0.39	GO:0051384	response to glucocorticoid
0.39	GO:0042866	pyruvate biosynthetic process

0.80	GO:0004760	serine-pyruvate transaminase activity
0.80	GO:0008453	alanine-glyoxylate transaminase activity
0.57	GO:0043621	protein self-association
0.52	GO:0042803	protein homodimerization activity
0.51	GO:0016597	amino acid binding
0.50	GO:0005102	receptor binding
0.47	GO:0070279	vitamin B6 binding
0.44	GO:0050662	coenzyme binding
0.36	GO:0004038	allantoinase activity
0.36	GO:0050897	cobalt ion binding

0.56	GO:0031907	microbody lumen
0.55	GO:0005777	peroxisome
0.39	GO:0005759	mitochondrial matrix

0.80	EC:2.6.1.51	GO:0004760
0.80	KEGG:R00585	GO:0004760

sp|P21554|CNR1_HUMAN
Cannabinoid receptor 1
Search

CNR1

0.91	Cannabinoid receptor

0.86	GO:0038171	cannabinoid signaling pathway
0.58	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
0.54	GO:0099553	trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
0.52	GO:0007413	axonal fasciculation
0.49	GO:0042593	glucose homeostasis
0.41	GO:0033602	negative regulation of dopamine secretion
0.41	GO:0060405	regulation of penile erection
0.41	GO:0031999	negative regulation of fatty acid beta-oxidation
0.41	GO:0031622	positive regulation of fever generation
0.40	GO:0045759	negative regulation of action potential

0.86	GO:0004949	cannabinoid receptor activity
0.34	GO:0008144	drug binding
0.34	GO:0005515	protein binding

0.51	GO:0042734	presynaptic membrane
0.51	GO:0030426	growth cone
0.50	GO:0030424	axon
0.40	GO:0005741	mitochondrial outer membrane
0.40	GO:0045121	membrane raft
0.33	GO:0005887	integral component of plasma membrane

sp|P21579|SYT1_HUMAN
Synaptotagmin-1
Search

SYT1

0.88	Synaptotagmin Ia

0.82	GO:0099643	signal release from synapse
0.82	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.75	GO:0006836	neurotransmitter transport
0.72	GO:0001505	regulation of neurotransmitter levels
0.68	GO:0051649	establishment of localization in cell
0.62	GO:1903861	positive regulation of dendrite extension
0.59	GO:0017158	regulation of calcium ion-dependent exocytosis
0.57	GO:0017156	calcium ion regulated exocytosis
0.56	GO:0097479	synaptic vesicle localization
0.56	GO:0099003	vesicle-mediated transport in synapse

0.81	GO:0005544	calcium-dependent phospholipid binding
0.57	GO:0050750	low-density lipoprotein particle receptor binding
0.57	GO:0019905	syntaxin binding
0.55	GO:0048306	calcium-dependent protein binding
0.50	GO:0005509	calcium ion binding
0.49	GO:0030276	clathrin binding
0.47	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.41	GO:0001786	phosphatidylserine binding
0.40	GO:0005516	calmodulin binding
0.39	GO:0008022	protein C-terminus binding

0.81	GO:0008021	synaptic vesicle
0.59	GO:0099501	exocytic vesicle membrane
0.57	GO:0031045	dense core granule
0.55	GO:0042734	presynaptic membrane
0.52	GO:0030424	axon
0.48	GO:0005794	Golgi apparatus
0.48	GO:0005829	cytosol
0.45	GO:0042584	chromaffin granule membrane
0.41	GO:0030054	cell junction
0.40	GO:0060076	excitatory synapse

sp|P21580|TNAP3_HUMAN
Tumor necrosis factor alpha-induced protein 3
Search

TNFAIP3

0.95	TNF alpha induced protein 3

0.85	GO:2000349	negative regulation of CD40 signaling pathway
0.84	GO:0034147	regulation of toll-like receptor 5 signaling pathway
0.84	GO:0070429	negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
0.84	GO:0072573	tolerance induction to lipopolysaccharide
0.84	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway
0.83	GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
0.82	GO:0001922	B-1 B cell homeostasis
0.82	GO:0002677	negative regulation of chronic inflammatory response
0.82	GO:2000347	positive regulation of hepatocyte proliferation
0.81	GO:0002634	regulation of germinal center formation

0.77	GO:0043621	protein self-association
0.76	GO:0002020	protease binding
0.73	GO:0043130	ubiquitin binding
0.72	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.70	GO:0019900	kinase binding
0.67	GO:0042802	identical protein binding
0.67	GO:0004842	ubiquitin-protein transferase activity
0.63	GO:0008270	zinc ion binding
0.59	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding
0.55	GO:0003677	DNA binding

0.57	GO:0005634	nucleus
0.46	GO:0005737	cytoplasm
0.39	GO:0070062	extracellular exosome

0.67

KEGG:R03876

GO:0004842

sp|P21583|SCF_HUMAN
Kit ligand
Search

KITLG

0.97	Kit ligand

0.71	GO:0007155	cell adhesion
0.65	GO:0010469	regulation of receptor activity
0.64	GO:0033026	negative regulation of mast cell apoptotic process
0.63	GO:0070668	positive regulation of mast cell proliferation
0.63	GO:1902035	positive regulation of hematopoietic stem cell proliferation
0.62	GO:0045636	positive regulation of melanocyte differentiation
0.62	GO:0035162	embryonic hemopoiesis
0.61	GO:0035234	ectopic germ cell programmed cell death
0.61	GO:0045740	positive regulation of DNA replication
0.60	GO:0008584	male gonad development

0.86	GO:0005173	stem cell factor receptor binding
0.67	GO:0008083	growth factor activity
0.56	GO:0005125	cytokine activity
0.37	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.36	GO:0005088	Ras guanyl-nucleotide exchange factor activity

0.64	GO:0030175	filopodium
0.62	GO:0030027	lamellipodium
0.52	GO:0005615	extracellular space
0.50	GO:0005886	plasma membrane
0.44	GO:0005856	cytoskeleton
0.42	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.37	EC:2.7.1.153	GO:0046934
0.37	KEGG:R04545	GO:0046934

sp|P21589|5NTD_HUMAN
5'-nucleotidase
Search

NT5E

0.49	Snake venom 5'-nucleotidase

0.75	GO:0009166	nucleotide catabolic process
0.60	GO:0046086	adenosine biosynthetic process
0.58	GO:0007159	leukocyte cell-cell adhesion
0.58	GO:0009169	purine ribonucleoside monophosphate catabolic process
0.56	GO:0050728	negative regulation of inflammatory response
0.52	GO:0072523	purine-containing compound catabolic process
0.51	GO:0046033	AMP metabolic process
0.50	GO:0016311	dephosphorylation
0.49	GO:0042737	drug catabolic process
0.49	GO:1901136	carbohydrate derivative catabolic process

0.59	GO:0016788	hydrolase activity, acting on ester bonds
0.52	GO:1901265	nucleoside phosphate binding
0.51	GO:0046872	metal ion binding
0.51	GO:0036094	small molecule binding

0.49	GO:0005654	nucleoplasm
0.48	GO:0005829	cytosol
0.43	GO:0005886	plasma membrane
0.41	GO:0031225	anchored component of membrane
0.37	GO:0070062	extracellular exosome
0.36	GO:0009986	cell surface
0.34	GO:0044456	synapse part
0.30	GO:0016021	integral component of membrane

0.59

EC:3.1

GO:0016788

sp|P21673|SAT1_HUMAN
Diamine acetyltransferase 1
Search

SAT1

0.96	Spermidine/spermine N-acetyltransferase

0.54	GO:0001525	angiogenesis
0.51	GO:0032918	spermidine acetylation
0.50	GO:0046208	spermine catabolic process
0.49	GO:0042127	regulation of cell proliferation
0.43	GO:0009447	putrescine catabolic process
0.38	GO:0032919	spermine acetylation
0.34	GO:0006596	polyamine biosynthetic process

0.85	GO:0004145	diamine N-acetyltransferase activity
0.51	GO:0019809	spermidine binding
0.50	GO:0042802	identical protein binding

0.42	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.85

EC:2.3.1.57

GO:0004145

sp|P21675|TAF1_HUMAN
Transcription initiation factor TFIID subunit 1
Search

TAF1

0.72	Transcription initiation factor TFIID subunit

0.68	GO:0006352	DNA-templated transcription, initiation
0.60	GO:0006468	protein phosphorylation
0.56	GO:0006413	translational initiation
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.49	GO:0016573	histone acetylation
0.49	GO:0030901	midbrain development
0.48	GO:1902680	positive regulation of RNA biosynthetic process
0.47	GO:1905524	negative regulation of protein autoubiquitination

0.67	GO:0004674	protein serine/threonine kinase activity
0.57	GO:0003743	translation initiation factor activity
0.54	GO:0003677	DNA binding
0.51	GO:0017025	TBP-class protein binding
0.50	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
0.50	GO:0004402	histone acetyltransferase activity
0.50	GO:0001129	RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly
0.46	GO:0140033	acetylation-dependent protein binding
0.45	GO:0061628	H3K27me3 modified histone binding
0.44	GO:0061631	ubiquitin conjugating enzyme activity

0.78	GO:0005669	transcription factor TFIID complex
0.44	GO:0071339	MLL1 complex
0.41	GO:0000790	nuclear chromatin
0.40	GO:0005730	nucleolus
0.37	GO:0045120	pronucleus
0.30	GO:0016020	membrane

0.67

GO:0004674

sp|P21695|GPDA_HUMAN
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
Search

GPD1

0.67	Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

0.78	GO:0046168	glycerol-3-phosphate catabolic process
0.60	GO:0005975	carbohydrate metabolic process
0.58	GO:0006127	glycerophosphate shuttle
0.57	GO:0045821	positive regulation of glycolytic process
0.56	GO:0071320	cellular response to cAMP
0.54	GO:0071356	cellular response to tumor necrosis factor
0.43	GO:0044283	small molecule biosynthetic process
0.38	GO:1901576	organic substance biosynthetic process
0.37	GO:0046486	glycerolipid metabolic process
0.35	GO:0090038	negative regulation of protein kinase C signaling

0.78	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity
0.75	GO:0042803	protein homodimerization activity
0.67	GO:0051287	NAD binding
0.39	GO:0004368	glycerol-3-phosphate dehydrogenase activity
0.34	GO:0017080	sodium channel regulator activity
0.34	GO:0044325	ion channel binding

0.75	GO:0009331	glycerol-3-phosphate dehydrogenase complex
0.44	GO:0005739	mitochondrion
0.37	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.35	GO:0071565	nBAF complex
0.35	GO:0071564	npBAF complex
0.34	GO:0016514	SWI/SNF complex
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.78	EC:1.1.1.8 EC:1.1.1.94	GO:0004367
0.78	KEGG:R00842	GO:0004367

sp|P21709|EPHA1_HUMAN
Ephrin type-A receptor 1
Search

EPHA1

0.86	Eph receptor A2 b

0.84	GO:0048013	ephrin receptor signaling pathway
0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.71	GO:0001954	positive regulation of cell-matrix adhesion
0.71	GO:0051496	positive regulation of stress fiber assembly
0.70	GO:0034446	substrate adhesion-dependent cell spreading
0.69	GO:0090630	activation of GTPase activity
0.68	GO:0045766	positive regulation of angiogenesis
0.67	GO:0030336	negative regulation of cell migration
0.66	GO:0046777	protein autophosphorylation
0.66	GO:0030335	positive regulation of cell migration

0.85	GO:0005003	ephrin receptor activity
0.64	GO:0019901	protein kinase binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.67	GO:0005887	integral component of plasma membrane
0.38	GO:0009986	cell surface
0.35	GO:0070062	extracellular exosome

sp|P21728|DRD1_HUMAN
D(1A) dopamine receptor
Search

DRD1

0.97	Dopamine receptor D1

0.85	GO:0007212	dopamine receptor signaling pathway
0.83	GO:0042311	vasodilation
0.83	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.60	GO:1903351	cellular response to dopamine
0.59	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
0.59	GO:0007190	activation of adenylate cyclase activity
0.58	GO:0046960	sensitization
0.58	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
0.58	GO:0035106	operant conditioning
0.57	GO:0001661	conditioned taste aversion

0.85	GO:0004952	dopamine neurotransmitter receptor activity
0.60	GO:0035240	dopamine binding
0.36	GO:0031750	D3 dopamine receptor binding
0.36	GO:0031701	angiotensin receptor binding
0.35	GO:0001965	G-protein alpha-subunit binding
0.35	GO:0051117	ATPase binding
0.35	GO:0019903	protein phosphatase binding
0.34	GO:0032403	protein complex binding
0.34	GO:0046982	protein heterodimerization activity

0.66	GO:0005887	integral component of plasma membrane
0.58	GO:0060170	ciliary membrane
0.57	GO:0097730	non-motile cilium
0.48	GO:0005783	endoplasmic reticulum
0.43	GO:0005634	nucleus
0.40	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.39	GO:0031984	organelle subcompartment
0.37	GO:0031526	brush border membrane
0.36	GO:0044326	dendritic spine neck
0.36	GO:0044327	dendritic spine head

sp|P21730|C5AR1_HUMAN
C5a anaphylatoxin chemotactic receptor 1
Search

C5AR1

0.90	Complement component 5a receptor 2

0.79	GO:0002430	complement receptor mediated signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.64	GO:0006935	chemotaxis
0.62	GO:0042789	mRNA transcription by RNA polymerase II
0.61	GO:0010759	positive regulation of macrophage chemotaxis
0.60	GO:0071624	positive regulation of granulocyte chemotaxis
0.60	GO:0010575	positive regulation of vascular endothelial growth factor production
0.60	GO:0090022	regulation of neutrophil chemotaxis
0.59	GO:1902624	positive regulation of neutrophil migration
0.59	GO:0070374	positive regulation of ERK1 and ERK2 cascade

0.80	GO:0004875	complement receptor activity
0.78	GO:0001847	opsonin receptor activity
0.72	GO:0004930	G-protein coupled receptor activity
0.42	GO:0001856	complement component C5a binding
0.37	GO:0042923	neuropeptide binding
0.35	GO:0019956	chemokine binding
0.35	GO:0015026	coreceptor activity
0.34	GO:0005124	scavenger receptor binding
0.33	GO:0001653	peptide receptor activity

0.58	GO:0016323	basolateral plasma membrane
0.57	GO:0045177	apical part of cell
0.45	GO:0005887	integral component of plasma membrane
0.44	GO:0031410	cytoplasmic vesicle
0.37	GO:0009986	cell surface
0.36	GO:0012506	vesicle membrane
0.36	GO:0043005	neuron projection
0.36	GO:0098805	whole membrane
0.35	GO:0098588	bounding membrane of organelle
0.35	GO:0012505	endomembrane system

sp|P21731|TA2R_HUMAN
Thromboxane A2 receptor
Search

TBXA2R

0.96	Prostaglandin F receptor isoform A

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.61	GO:0032496	response to lipopolysaccharide
0.60	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
0.59	GO:0019229	regulation of vasoconstriction
0.59	GO:0045987	positive regulation of smooth muscle contraction
0.59	GO:0019932	second-messenger-mediated signaling
0.55	GO:0006954	inflammatory response
0.50	GO:0071799	cellular response to prostaglandin D stimulus
0.49	GO:0045777	positive regulation of blood pressure
0.48	GO:0032355	response to estradiol

0.85	GO:0004954	prostanoid receptor activity
0.35	GO:0005085	guanyl-nucleotide exchange factor activity

0.55	GO:0016607	nuclear speck
0.45	GO:0005886	plasma membrane
0.42	GO:0005576	extracellular region
0.40	GO:0001669	acrosomal vesicle
0.30	GO:0016021	integral component of membrane

sp|P21741|MK_HUMAN
Midkine
Search

MDK

0.97	Midkine (neurite growth-promoting factor 2)

0.75	GO:0010469	regulation of receptor activity
0.58	GO:0030421	defecation
0.57	GO:0021681	cerebellar granular layer development
0.57	GO:0021542	dentate gyrus development
0.57	GO:0007614	short-term memory
0.56	GO:0001662	behavioral fear response
0.55	GO:0021987	cerebral cortex development
0.55	GO:0043524	negative regulation of neuron apoptotic process
0.54	GO:0050795	regulation of behavior
0.54	GO:0009611	response to wounding

0.78	GO:0008083	growth factor activity
0.55	GO:0008201	heparin binding
0.38	GO:0043395	heparan sulfate proteoglycan binding

0.41	GO:0005576	extracellular region
0.36	GO:0042995	cell projection
0.35	GO:0005794	Golgi apparatus
0.34	GO:0009986	cell surface

sp|P21754|ZP3_HUMAN
Zona pellucida sperm-binding protein 3
Search

ZP3

0.93	Zona pellucida protein subunit C

0.65	GO:0001809	positive regulation of type IV hypersensitivity
0.65	GO:2000387	regulation of antral ovarian follicle growth
0.65	GO:2000386	positive regulation of ovarian follicle development
0.65	GO:0035803	egg coat formation
0.64	GO:2000344	positive regulation of acrosome reaction
0.62	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process
0.62	GO:0007339	binding of sperm to zona pellucida
0.61	GO:0032753	positive regulation of interleukin-4 production
0.61	GO:0001825	blastocyst formation
0.60	GO:0090280	positive regulation of calcium ion import

0.59	GO:0035804	structural constituent of egg coat
0.54	GO:0048018	receptor ligand activity
0.52	GO:0032190	acrosin binding
0.43	GO:0030246	carbohydrate binding
0.38	GO:0042802	identical protein binding
0.35	GO:0008270	zinc ion binding

0.61	GO:0005576	extracellular region
0.44	GO:0005886	plasma membrane
0.43	GO:0045177	apical part of cell
0.38	GO:0005622	intracellular
0.33	GO:0043234	protein complex
0.33	GO:0012505	endomembrane system
0.33	GO:0043233	organelle lumen
0.33	GO:0035805	egg coat
0.33	GO:0031090	organelle membrane
0.33	GO:0031975	envelope

sp|P21757|MSRE_HUMAN
Macrophage scavenger receptor types I and II
Search

MSR1

0.94	Macrophage scavenger receptor types I and II

0.71	GO:0006898	receptor-mediated endocytosis
0.62	GO:0097242	amyloid-beta clearance
0.61	GO:0010886	positive regulation of cholesterol storage
0.61	GO:0010744	positive regulation of macrophage derived foam cell differentiation
0.60	GO:0034381	plasma lipoprotein particle clearance
0.59	GO:0006911	phagocytosis, engulfment
0.58	GO:0030301	cholesterol transport
0.55	GO:0042953	lipoprotein transport
0.51	GO:0034755	iron ion transmembrane transport
0.50	GO:0006879	cellular iron ion homeostasis

0.80	GO:0005044	scavenger receptor activity
0.61	GO:0030169	low-density lipoprotein particle binding
0.59	GO:0001540	amyloid-beta binding
0.58	GO:0070287	ferritin receptor activity
0.37	GO:0051879	Hsp90 protein binding
0.37	GO:0030544	Hsp70 protein binding
0.35	GO:0042802	identical protein binding
0.35	GO:0019899	enzyme binding
0.32	GO:0104005	hijacked molecular function
0.32	GO:0030246	carbohydrate binding

0.47	GO:0005886	plasma membrane
0.44	GO:0009986	cell surface
0.44	GO:0034362	low-density lipoprotein particle
0.41	GO:0005581	collagen trimer
0.37	GO:0030666	endocytic vesicle membrane
0.34	GO:0005829	cytosol
0.32	GO:0098552	side of membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P21781|FGF7_HUMAN
Fibroblast growth factor 7
Search

FGF7

0.63	Fibroblast growth factor

0.84	GO:0008543	fibroblast growth factor receptor signaling pathway
0.75	GO:0010469	regulation of receptor activity
0.66	GO:0061033	secretion by lung epithelial cell involved in lung growth
0.64	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis
0.64	GO:0010838	positive regulation of keratinocyte proliferation
0.64	GO:0051549	positive regulation of keratinocyte migration
0.64	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
0.63	GO:0010463	mesenchymal cell proliferation
0.62	GO:0034394	protein localization to cell surface
0.62	GO:0060445	branching involved in salivary gland morphogenesis

0.85	GO:0005104	fibroblast growth factor receptor binding
0.78	GO:0008083	growth factor activity
0.62	GO:0042056	chemoattractant activity
0.44	GO:0008201	heparin binding
0.36	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.36	GO:0016303	1-phosphatidylinositol-3-kinase activity
0.35	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.35	GO:0004713	protein tyrosine kinase activity
0.34	GO:0004335	galactokinase activity
0.34	GO:0005534	galactose binding

0.66	GO:0005576	extracellular region
0.52	GO:0005794	Golgi apparatus
0.30	GO:0016020	membrane

0.36	EC:2.7.1.153	GO:0046934
0.36	KEGG:R04545	GO:0046934

sp|P21796|VDAC1_HUMAN
Voltage-dependent anion-selective channel protein 1
Search

VDAC1

0.94	Voltage-dependent anion-selective channel protein 1

0.69	GO:0098656	anion transmembrane transport
0.52	GO:0007270	neuron-neuron synaptic transmission
0.51	GO:0001662	behavioral fear response
0.51	GO:2000378	negative regulation of reactive oxygen species metabolic process
0.51	GO:1903146	regulation of autophagy of mitochondrion
0.50	GO:0007612	learning
0.49	GO:0006915	apoptotic process
0.49	GO:0030855	epithelial cell differentiation
0.39	GO:0006851	mitochondrial calcium ion transmembrane transport
0.34	GO:0016236	macroautophagy

0.78	GO:0008308	voltage-gated anion channel activity
0.51	GO:0044325	ion channel binding
0.48	GO:0019901	protein kinase binding
0.46	GO:0042802	identical protein binding
0.39	GO:0015288	porin activity
0.37	GO:0032403	protein complex binding
0.34	GO:1901265	nucleoside phosphate binding
0.34	GO:0005262	calcium channel activity
0.34	GO:0036094	small molecule binding

0.78	GO:0005741	mitochondrial outer membrane
0.54	GO:0005757	mitochondrial permeability transition pore complex
0.50	GO:0042645	mitochondrial nucleoid
0.49	GO:0043209	myelin sheath
0.42	GO:0019866	organelle inner membrane
0.40	GO:0005886	plasma membrane
0.40	GO:0045121	membrane raft
0.39	GO:0070382	exocytic vesicle
0.38	GO:0098793	presynapse
0.36	GO:0070062	extracellular exosome

sp|P21802|FGFR2_HUMAN
Fibroblast growth factor receptor 2
Search

FGFR2

0.75	Fibroblast growth factor receptor

0.81	GO:0008543	fibroblast growth factor receptor signaling pathway
0.76	GO:0008284	positive regulation of cell proliferation
0.75	GO:0018108	peptidyl-tyrosine phosphorylation
0.55	GO:0010518	positive regulation of phospholipase activity
0.53	GO:0048701	embryonic cranial skeleton morphogenesis
0.52	GO:0043410	positive regulation of MAPK cascade
0.52	GO:0046777	protein autophosphorylation
0.44	GO:0060615	mammary gland bud formation
0.44	GO:0060667	branch elongation involved in salivary gland morphogenesis
0.44	GO:0060915	mesenchymal cell differentiation involved in lung development

0.84	GO:0005007	fibroblast growth factor-activated receptor activity
0.55	GO:0017134	fibroblast growth factor binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0008144	drug binding
0.49	GO:0042803	protein homodimerization activity
0.36	GO:0008201	heparin binding
0.35	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.35	GO:0016303	1-phosphatidylinositol-3-kinase activity

0.49	GO:0005938	cell cortex
0.49	GO:0009986	cell surface
0.49	GO:0031012	extracellular matrix
0.47	GO:0005654	nucleoplasm
0.46	GO:0005887	integral component of plasma membrane
0.42	GO:0060076	excitatory synapse
0.36	GO:0031410	cytoplasmic vesicle
0.36	GO:0005794	Golgi apparatus

0.35	EC:2.7.1.153	GO:0046934
0.35	KEGG:R04545	GO:0046934

sp|P21810|PGS1_HUMAN
Biglycan
Search

BGN

0.96

Biglycan

0.60	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
0.49	GO:0046426	negative regulation of JAK-STAT cascade
0.47	GO:0006469	negative regulation of protein kinase activity
0.47	GO:0019221	cytokine-mediated signaling pathway
0.41	GO:0001974	blood vessel remodeling
0.37	GO:0030207	chondroitin sulfate catabolic process
0.37	GO:0030208	dermatan sulfate biosynthetic process
0.36	GO:0030206	chondroitin sulfate biosynthetic process
0.35	GO:0030198	extracellular matrix organization

0.56	GO:0050840	extracellular matrix binding
0.52	GO:0005539	glycosaminoglycan binding
0.48	GO:0004860	protein kinase inhibitor activity
0.35	GO:0005201	extracellular matrix structural constituent
0.31	GO:0005515	protein binding

0.75	GO:0005578	proteinaceous extracellular matrix
0.56	GO:0042383	sarcolemma
0.54	GO:0030133	transport vesicle
0.53	GO:0009986	cell surface
0.51	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.36	GO:0043202	lysosomal lumen
0.36	GO:0005796	Golgi lumen

sp|P21815|SIAL_HUMAN
Bone sialoprotein 2
Search

IBSP

0.97	Bone sialoprotein II

0.83	GO:0001503	ossification
0.72	GO:0007155	cell adhesion
0.70	GO:0031214	biomineral tissue development
0.68	GO:0030198	extracellular matrix organization
0.67	GO:0071363	cellular response to growth factor stimulus
0.63	GO:0045785	positive regulation of cell adhesion
0.41	GO:0007229	integrin-mediated signaling pathway
0.38	GO:0030154	cell differentiation

0.69

GO:0005178

integrin binding

0.66	GO:0005576	extracellular region
0.55	GO:0031982	vesicle
0.30	GO:0031224	intrinsic component of membrane

sp|P21817|RYR1_HUMAN
Ryanodine receptor 1
Search

RYR1

0.85	Skeletal muscle ryanodine receptor isoform alpha

0.84	GO:0051209	release of sequestered calcium ion into cytosol
0.59	GO:0071313	cellular response to caffeine
0.59	GO:0070296	sarcoplasmic reticulum calcium ion transport
0.58	GO:0043931	ossification involved in bone maturation
0.57	GO:0006936	muscle contraction
0.56	GO:0048741	skeletal muscle fiber development
0.56	GO:0003151	outflow tract morphogenesis
0.55	GO:0043588	skin development
0.52	GO:0001666	response to hypoxia
0.47	GO:0071277	cellular response to calcium ion

0.85	GO:0005219	ryanodine-sensitive calcium-release channel activity
0.67	GO:0005509	calcium ion binding
0.57	GO:0048763	calcium-induced calcium release activity
0.54	GO:0005245	voltage-gated calcium channel activity
0.53	GO:0002020	protease binding
0.45	GO:0005516	calmodulin binding
0.40	GO:0015643	toxic substance binding
0.38	GO:0097718	disordered domain specific binding
0.38	GO:0035381	ATP-gated ion channel activity
0.38	GO:0044325	ion channel binding

0.57	GO:0033017	sarcoplasmic reticulum membrane
0.56	GO:0030314	junctional membrane complex
0.55	GO:0005790	smooth endoplasmic reticulum
0.55	GO:0030315	T-tubule
0.53	GO:0031674	I band
0.50	GO:0014802	terminal cisterna
0.50	GO:0005938	cell cortex
0.45	GO:0005891	voltage-gated calcium channel complex
0.44	GO:0031301	integral component of organelle membrane
0.40	GO:0070062	extracellular exosome

sp|P21854|CD72_HUMAN
B-cell differentiation antigen CD72
Search

CD72

0.95	B-cell differentiation antigen CD72

0.37	GO:0007155	cell adhesion
0.37	GO:0006468	protein phosphorylation
0.35	GO:0007165	signal transduction

0.40	GO:0030246	carbohydrate binding
0.39	GO:0004674	protein serine/threonine kinase activity
0.37	GO:0005102	receptor binding
0.37	GO:0099600	transmembrane receptor activity
0.36	GO:0038023	signaling receptor activity
0.35	GO:0030554	adenyl nucleotide binding
0.35	GO:0097367	carbohydrate derivative binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding

0.54

GO:0005887

integral component of plasma membrane

0.39

GO:0004674

sp|P21860|ERBB3_HUMAN
Receptor tyrosine-protein kinase erbB-3
Search

0.66	V-erb-b2 erythroblastic leukemia viral oncogene homolog 3b

0.78	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.64	GO:0023014	signal transduction by protein phosphorylation
0.60	GO:0035556	intracellular signal transduction

0.84	GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity
0.80	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding

0.44	GO:0005622	intracellular
0.30	GO:0031224	intrinsic component of membrane

0.84

GO:0004716

sp|P21912|SDHB_HUMAN
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Search

SDHB

0.69	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

0.69	GO:0006099	tricarboxylic acid cycle
0.60	GO:0022900	electron transport chain
0.37	GO:0006105	succinate metabolic process
0.34	GO:0018101	protein citrullination

0.77	GO:0051538	3 iron, 4 sulfur cluster binding
0.77	GO:0008177	succinate dehydrogenase (ubiquinone) activity
0.69	GO:0051537	2 iron, 2 sulfur cluster binding
0.65	GO:0051539	4 iron, 4 sulfur cluster binding
0.61	GO:0009055	electron transfer activity
0.53	GO:0046872	metal ion binding
0.44	GO:0048039	ubiquinone binding
0.34	GO:0004668	protein-arginine deiminase activity
0.34	GO:0005515	protein binding

0.61	GO:0031966	mitochondrial membrane
0.61	GO:0019866	organelle inner membrane
0.54	GO:0045257	succinate dehydrogenase complex (ubiquinone)
0.54	GO:0045283	fumarate reductase complex
0.48	GO:0098798	mitochondrial protein complex
0.46	GO:0005654	nucleoplasm
0.40	GO:0005886	plasma membrane
0.36	GO:0070062	extracellular exosome

0.77	EC:1.3.5.1	GO:0008177
0.77	KEGG:R02164	GO:0008177

sp|P21917|DRD4_HUMAN
D(4) dopamine receptor
Search

DRD4

0.65	D(4) dopamine receptor

0.86	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
0.63	GO:0032417	positive regulation of sodium:proton antiporter activity
0.62	GO:0034776	response to histamine
0.62	GO:0060080	inhibitory postsynaptic potential
0.61	GO:0042053	regulation of dopamine metabolic process
0.61	GO:0048148	behavioral response to cocaine
0.61	GO:0001975	response to amphetamine
0.61	GO:1901386	negative regulation of voltage-gated calcium channel activity
0.60	GO:0042596	fear response
0.58	GO:0008344	adult locomotory behavior

0.85	GO:0004952	dopamine neurotransmitter receptor activity
0.63	GO:0051380	norepinephrine binding
0.63	GO:0051379	epinephrine binding
0.61	GO:0035240	dopamine binding
0.56	GO:0017124	SH3 domain binding
0.53	GO:0042802	identical protein binding
0.45	GO:0015459	potassium channel regulator activity
0.37	GO:0046872	metal ion binding

0.67	GO:0005887	integral component of plasma membrane
0.55	GO:0098794	postsynapse
0.33	GO:0043195	terminal bouton
0.33	GO:0044309	neuron spine
0.33	GO:0043025	neuronal cell body
0.33	GO:0030425	dendrite
0.33	GO:0012506	vesicle membrane
0.33	GO:0005938	cell cortex

sp|P21918|DRD5_HUMAN
D(1B) dopamine receptor
Search

DRD5

0.94	Dopamine receptor 5

0.85	GO:0007212	dopamine receptor signaling pathway
0.84	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.68	GO:0097746	regulation of blood vessel diameter
0.60	GO:0046960	sensitization
0.60	GO:0033861	negative regulation of NAD(P)H oxidase activity
0.60	GO:0071870	cellular response to catecholamine stimulus
0.58	GO:0060292	long term synaptic depression
0.58	GO:0001975	response to amphetamine
0.58	GO:0001992	regulation of systemic arterial blood pressure by vasopressin
0.58	GO:0003321	positive regulation of blood pressure by epinephrine-norepinephrine

0.85	GO:0004952	dopamine neurotransmitter receptor activity
0.60	GO:0035240	dopamine binding
0.35	GO:0001965	G-protein alpha-subunit binding

0.67	GO:0005887	integral component of plasma membrane
0.58	GO:0060170	ciliary membrane
0.57	GO:0097730	non-motile cilium
0.55	GO:0031526	brush border membrane
0.45	GO:0005622	intracellular
0.37	GO:0012505	endomembrane system
0.35	GO:0043197	dendritic spine
0.35	GO:0043025	neuronal cell body
0.35	GO:0030424	axon

sp|P21926|CD9_HUMAN
CD9 antigen
Search

CD9

0.61	Tetraspanin

0.56	GO:0090331	negative regulation of platelet aggregation
0.55	GO:0030913	paranodal junction assembly
0.54	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization
0.54	GO:0071404	cellular response to low-density lipoprotein particle stimulus
0.53	GO:0031623	receptor internalization
0.52	GO:0051271	negative regulation of cellular component movement
0.50	GO:0008285	negative regulation of cell proliferation
0.48	GO:0007155	cell adhesion
0.40	GO:0007166	cell surface receptor signaling pathway

0.52	GO:0070062	extracellular exosome
0.51	GO:0009897	external side of plasma membrane
0.39	GO:0005887	integral component of plasma membrane

sp|P21941|MATN1_HUMAN
Cartilage matrix protein
Search

MATN1

0.96	cartilage matrix protein isoform X1

0.59	GO:0003429	growth plate cartilage chondrocyte morphogenesis
0.54	GO:0030500	regulation of bone mineralization
0.37	GO:1901031	regulation of response to reactive oxygen species
0.36	GO:0030198	extracellular matrix organization
0.35	GO:0006461	protein complex assembly

0.80	GO:0005201	extracellular matrix structural constituent
0.69	GO:0005509	calcium ion binding
0.37	GO:0000287	magnesium ion binding
0.36	GO:0005515	protein binding
0.33	GO:0003677	DNA binding

0.74	GO:0005578	proteinaceous extracellular matrix
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P21953|ODBB_HUMAN
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
Search

BCKDHB

0.92	Branched chain keto acid dehydrogenase E1 beta polypeptide

0.62	GO:0009083	branched-chain amino acid catabolic process
0.44	GO:0055114	oxidation-reduction process

0.62	GO:0003826	alpha-ketoacid dehydrogenase activity
0.36	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity

0.67

GO:0005947

mitochondrial alpha-ketoglutarate dehydrogenase complex

0.36

EC:1.2.4.1

GO:0004739

sp|P21964|COMT_HUMAN
Catechol O-methyltransferase
Search

COMT

0.54	Membrane bound catechol-O-methyltransferase

0.81	GO:0006584	catecholamine metabolic process
0.70	GO:0042135	neurotransmitter catabolic process
0.63	GO:0032259	methylation
0.54	GO:0016036	cellular response to phosphate starvation
0.53	GO:0019614	catechol-containing compound catabolic process
0.50	GO:0097164	ammonium ion metabolic process
0.49	GO:0042737	drug catabolic process
0.46	GO:1901565	organonitrogen compound catabolic process
0.43	GO:0050668	positive regulation of homocysteine metabolic process
0.42	GO:0045963	negative regulation of dopamine metabolic process

0.85	GO:0016206	catechol O-methyltransferase activity
0.61	GO:0000287	magnesium ion binding
0.45	GO:0102084	L-dopa O-methyltransferase activity
0.45	GO:0102938	orcinol O-methyltransferase activity
0.34	GO:0005515	protein binding

0.44	GO:0005739	mitochondrion
0.40	GO:0043197	dendritic spine
0.39	GO:0044297	cell body
0.39	GO:0030424	axon
0.39	GO:0045211	postsynaptic membrane
0.37	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.85

EC:2.1.1.6

GO:0016206

sp|P21980|TGM2_HUMAN
Protein-glutamine gamma-glutamyltransferase 2
Search

TGM2

0.97	Tissue-type transglutaminase

0.84	GO:0018149	peptide cross-linking
0.62	GO:0060662	salivary gland cavitation
0.62	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
0.62	GO:0051561	positive regulation of mitochondrial calcium ion concentration
0.61	GO:0060445	branching involved in salivary gland morphogenesis
0.59	GO:0043277	apoptotic cell clearance
0.55	GO:0043065	positive regulation of apoptotic process
0.54	GO:0045785	positive regulation of cell adhesion
0.42	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
0.42	GO:0001974	blood vessel remodeling

0.84	GO:0003810	protein-glutamine gamma-glutamyltransferase activity
0.40	GO:0019904	protein domain specific binding
0.37	GO:0032550	purine ribonucleoside binding
0.37	GO:0019001	guanyl nucleotide binding
0.36	GO:0019899	enzyme binding
0.35	GO:0046872	metal ion binding
0.35	GO:0008483	transaminase activity
0.35	GO:0032555	purine ribonucleotide binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0098772	molecular function regulator

0.51	GO:0005783	endoplasmic reticulum
0.50	GO:0005829	cytosol
0.49	GO:0031226	intrinsic component of plasma membrane
0.46	GO:0005739	mitochondrion
0.38	GO:0005925	focal adhesion
0.38	GO:0070062	extracellular exosome
0.38	GO:0031012	extracellular matrix
0.30	GO:0016021	integral component of membrane

0.84

EC:2.3.2.13

GO:0003810

sp|P22001|KCNA3_HUMAN
Potassium voltage-gated channel subfamily A member 3
Search

KCNA3

0.94	Glibenclamide-sensitive voltage-gated potassium channel

0.77	GO:0051260	protein homooligomerization
0.77	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport

0.78	GO:0005249	voltage-gated potassium channel activity
0.34	GO:0005515	protein binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.50	GO:0030424	axon
0.38	GO:0045121	membrane raft

sp|P22003|BMP5_HUMAN
Bone morphogenetic protein 5
Search

BMP5

0.97	Bone morphogenenic protein-5

0.74	GO:0010469	regulation of receptor activity
0.63	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.62	GO:0032345	negative regulation of aldosterone metabolic process
0.62	GO:2000065	negative regulation of cortisol biosynthetic process
0.62	GO:0032347	regulation of aldosterone biosynthetic process
0.61	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway
0.60	GO:0003323	type B pancreatic cell development
0.59	GO:1900006	positive regulation of dendrite development
0.59	GO:2000105	positive regulation of DNA-dependent DNA replication
0.57	GO:0050679	positive regulation of epithelial cell proliferation

0.76	GO:0008083	growth factor activity
0.63	GO:0070700	BMP receptor binding
0.48	GO:0005160	transforming growth factor beta receptor binding
0.46	GO:0005125	cytokine activity
0.34	GO:0046982	protein heterodimerization activity
0.34	GO:0008201	heparin binding

0.65	GO:0005576	extracellular region
0.37	GO:0031982	vesicle
0.30	GO:0016020	membrane
0.30	GO:0005623	cell

sp|P22004|BMP6_HUMAN
Bone morphogenetic protein 6
Search

BMP6

0.88	LOW QUALITY PROTEIN: bone morphogenetic protein 6

0.74	GO:0010469	regulation of receptor activity
0.61	GO:0032347	regulation of aldosterone biosynthetic process
0.60	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.59	GO:0003323	type B pancreatic cell development
0.56	GO:0050679	positive regulation of epithelial cell proliferation
0.56	GO:0030539	male genitalia development
0.56	GO:0032346	positive regulation of aldosterone metabolic process
0.55	GO:0090031	positive regulation of steroid hormone biosynthetic process
0.55	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
0.55	GO:0060586	multicellular organismal iron ion homeostasis

0.76	GO:0008083	growth factor activity
0.61	GO:0070700	BMP receptor binding
0.48	GO:0046982	protein heterodimerization activity
0.46	GO:0005160	transforming growth factor beta receptor binding
0.44	GO:0005125	cytokine activity

0.65	GO:0005576	extracellular region
0.39	GO:0031982	vesicle
0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|P22033|MUTA_HUMAN
Methylmalonyl-CoA mutase, mitochondrial
Search

MUT

0.46	Methylmalonyl Coenzyme A mutase

0.54	GO:0050667	homocysteine metabolic process
0.51	GO:0043547	positive regulation of GTPase activity
0.49	GO:0009791	post-embryonic development
0.34	GO:0019626	short-chain fatty acid catabolic process
0.34	GO:0009235	cobalamin metabolic process

0.80	GO:0004494	methylmalonyl-CoA mutase activity
0.75	GO:0031419	cobalamin binding
0.53	GO:0046872	metal ion binding
0.52	GO:0042803	protein homodimerization activity
0.51	GO:0072341	modified amino acid binding
0.48	GO:0003924	GTPase activity

0.43	GO:0005739	mitochondrion
0.38	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part

0.80	EC:5.4.99.2	GO:0004494
0.80	KEGG:R00833	GO:0004494

sp|P22059|OSBP1_HUMAN
Oxysterol-binding protein 1
Search

OSBP

0.53	Oxysterol-binding protein (Fragment)

0.73	GO:0006869	lipid transport
0.62	GO:0044128	positive regulation of growth of symbiont in host
0.53	GO:0015850	organic hydroxy compound transport
0.37	GO:0007286	spermatid development

0.57	GO:0015248	sterol transporter activity
0.56	GO:0070273	phosphatidylinositol-4-phosphate binding
0.52	GO:0019904	protein domain specific binding
0.37	GO:0015485	cholesterol binding

0.54	GO:0048471	perinuclear region of cytoplasm
0.51	GO:0030054	cell junction
0.51	GO:0000139	Golgi membrane
0.51	GO:0005730	nucleolus
0.49	GO:0005654	nucleoplasm
0.48	GO:0005829	cytosol
0.38	GO:0097440	apical dendrite

sp|P22061|PIMT_HUMAN
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Search

PCMT1

0.43	L-isoaspartyl protein carboxyl methyltransferase

0.73	GO:0008213	protein alkylation
0.67	GO:0043414	macromolecule methylation
0.35	GO:0010667	negative regulation of cardiac muscle cell apoptotic process
0.35	GO:0045471	response to ethanol
0.35	GO:0071456	cellular response to hypoxia
0.34	GO:0007568	aging
0.34	GO:0030091	protein repair
0.34	GO:0046498	S-adenosylhomocysteine metabolic process
0.34	GO:0046500	S-adenosylmethionine metabolic process
0.32	GO:0042254	ribosome biogenesis

0.79	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
0.36	GO:0045296	cadherin binding

0.47	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome
0.35	GO:0031526	brush border membrane
0.35	GO:0043204	perikaryon
0.34	GO:0016323	basolateral plasma membrane
0.34	GO:0043005	neuron projection
0.30	GO:0016021	integral component of membrane

0.79

EC:2.1.1.77

GO:0004719

sp|P22079|PERL_HUMAN
Lactoperoxidase
Search

LPO

0.45	lactoperoxidase precursor

0.77	GO:0018969	thiocyanate metabolic process
0.72	GO:0006952	defense response
0.71	GO:0006979	response to oxidative stress
0.69	GO:0098869	cellular oxidant detoxification
0.66	GO:0009617	response to bacterium
0.58	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
0.53	GO:0055114	oxidation-reduction process
0.51	GO:0002148	hypochlorous acid metabolic process
0.50	GO:0032714	negative regulation of interleukin-5 production
0.49	GO:0072677	eosinophil migration

0.77	GO:0036393	thiocyanate peroxidase activity
0.63	GO:0020037	heme binding
0.44	GO:0008201	heparin binding
0.36	GO:0046872	metal ion binding
0.34	GO:0004984	olfactory receptor activity

0.55	GO:0005615	extracellular space
0.55	GO:0016323	basolateral plasma membrane
0.45	GO:0005766	primary lysosome
0.44	GO:0030141	secretory granule
0.39	GO:1903561	extracellular vesicle
0.38	GO:0005634	nucleus
0.38	GO:0005739	mitochondrion
0.34	GO:0060205	cytoplasmic vesicle lumen
0.30	GO:0031224	intrinsic component of membrane

sp|P22083|FUT4_HUMAN
Alpha-(1,3)-fucosyltransferase 4
Search

FUT4

0.63	Fucosyltransferase 4

0.81	GO:0036065	fucosylation
0.74	GO:0006486	protein glycosylation
0.39	GO:0042355	L-fucose catabolic process
0.38	GO:0006672	ceramide metabolic process
0.37	GO:0031047	gene silencing by RNA
0.35	GO:0009312	oligosaccharide biosynthetic process
0.34	GO:0009988	cell-cell recognition

0.81	GO:0008417	fucosyltransferase activity
0.33	GO:0003676	nucleic acid binding

0.81	GO:0032580	Golgi cisterna membrane
0.52	GO:0009986	cell surface
0.42	GO:0071944	cell periphery
0.34	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.81

GO:0008417

sp|P22087|FBRL_HUMAN
rRNA 2'-O-methyltransferase fibrillarin
Search

FBL

0.75	LOW QUALITY PROTEIN: rRNA 2'-O-methyltransferase fibrillarin

0.66	GO:0006364	rRNA processing
0.64	GO:0008033	tRNA processing
0.61	GO:0032259	methylation
0.55	GO:0016074	snoRNA metabolic process
0.54	GO:0048254	snoRNA localization
0.50	GO:0016570	histone modification
0.50	GO:0008213	protein alkylation
0.47	GO:0043628	ncRNA 3'-end processing
0.43	GO:0009451	RNA modification
0.38	GO:0001649	osteoblast differentiation

0.61	GO:0008168	methyltransferase activity
0.57	GO:0003723	RNA binding
0.53	GO:0001094	TFIID-class transcription factor binding
0.52	GO:0051117	ATPase binding
0.45	GO:0140102	catalytic activity, acting on a rRNA
0.43	GO:0140096	catalytic activity, acting on a protein

0.58	GO:0001650	fibrillar center
0.55	GO:0015030	Cajal body
0.54	GO:0001652	granular component
0.50	GO:0031428	box C/D snoRNP complex
0.48	GO:0032040	small-subunit processome
0.41	GO:0001651	dense fibrillar component
0.37	GO:0070062	extracellular exosome
0.36	GO:0005694	chromosome
0.30	GO:0016020	membrane

0.61

EC:2.1.1

GO:0008168

sp|P22090|RS4Y1_HUMAN
40S ribosomal protein S4, Y isoform 1
Search

0.67	Ribosomal protein S4, X-linked X isoform variant (Fragment)

0.60	GO:0043043	peptide biosynthetic process
0.55	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.52	GO:0009059	macromolecule biosynthetic process
0.45	GO:0007275	multicellular organism development
0.43	GO:0008284	positive regulation of cell proliferation
0.43	GO:0045727	positive regulation of translation
0.40	GO:0060322	head development
0.34	GO:0045471	response to ethanol
0.34	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

0.64	GO:0003735	structural constituent of ribosome
0.62	GO:0019843	rRNA binding

0.61	GO:0005840	ribosome
0.46	GO:0005844	polysome
0.45	GO:0044445	cytosolic part
0.43	GO:0036464	cytoplasmic ribonucleoprotein granule
0.40	GO:0044446	intracellular organelle part
0.33	GO:0031974	membrane-enclosed lumen
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P22102|PUR2_HUMAN
Trifunctional purine biosynthetic protein adenosine-3
Search

GART

0.91	Trifunctional purine biosynthetic protein adenosine-3

0.73	GO:0009113	purine nucleobase biosynthetic process
0.69	GO:0006189	'de novo' IMP biosynthetic process
0.41	GO:0048513	animal organ development
0.41	GO:0043473	pigmentation
0.40	GO:0043009	chordate embryonic development
0.40	GO:0003360	brainstem development
0.38	GO:0060322	head development
0.37	GO:0007417	central nervous system development
0.37	GO:0046654	tetrahydrofolate biosynthetic process
0.37	GO:0006544	glycine metabolic process

0.76	GO:0004637	phosphoribosylamine-glycine ligase activity
0.76	GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity
0.75	GO:0004644	phosphoribosylglycinamide formyltransferase activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0046872	metal ion binding

0.48	GO:0005737	cytoplasm
0.37	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.76	EC:6.3.4.13	GO:0004637
0.76	KEGG:R04144	GO:0004637

sp|P22105|TENX_HUMAN
Tenascin-X
Search

TNXB

0.53	Tenascin XB

0.85	GO:0030199	collagen fibril organization
0.63	GO:0043506	regulation of JUN kinase activity
0.61	GO:0007160	cell-matrix adhesion
0.61	GO:0006641	triglyceride metabolic process
0.58	GO:0098609	cell-cell adhesion
0.53	GO:0006631	fatty acid metabolic process
0.48	GO:0048251	elastic fiber assembly
0.48	GO:0032963	collagen metabolic process
0.41	GO:0045785	positive regulation of cell adhesion
0.39	GO:0006644	phospholipid metabolic process

0.63	GO:0008201	heparin binding
0.62	GO:0005518	collagen binding
0.41	GO:0005178	integrin binding
0.36	GO:0019838	growth factor binding
0.34	GO:0090729	toxin activity
0.33	GO:0045545	syndecan binding

0.75	GO:0005578	proteinaceous extracellular matrix
0.56	GO:0005615	extracellular space
0.46	GO:0044420	extracellular matrix component
0.45	GO:0005581	collagen trimer
0.43	GO:0099512	supramolecular fiber
0.35	GO:0005622	intracellular
0.35	GO:1903561	extracellular vesicle
0.30	GO:0031224	intrinsic component of membrane

sp|P22223|CADH3_HUMAN
Cadherin-3
Search

CDH3

0.96	Blastomere cadherin

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.62	GO:0060901	regulation of hair cycle by canonical Wnt signaling pathway
0.62	GO:1902910	positive regulation of melanosome transport
0.62	GO:0051796	negative regulation of timing of catagen
0.62	GO:0032771	regulation of monophenol monooxygenase activity
0.62	GO:0032912	negative regulation of transforming growth factor beta2 production
0.61	GO:0048023	positive regulation of melanin biosynthetic process
0.60	GO:0010838	positive regulation of keratinocyte proliferation
0.60	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
0.59	GO:0032770	positive regulation of monooxygenase activity

0.70	GO:0005509	calcium ion binding
0.53	GO:0045295	gamma-catenin binding
0.53	GO:0032794	GTPase activating protein binding
0.53	GO:0030506	ankyrin binding
0.50	GO:0008013	beta-catenin binding
0.50	GO:0045296	cadherin binding
0.47	GO:0042802	identical protein binding
0.37	GO:0045294	alpha-catenin binding
0.36	GO:0019903	protein phosphatase binding
0.35	GO:0019904	protein domain specific binding

0.60	GO:0005913	cell-cell adherens junction
0.55	GO:0005886	plasma membrane
0.50	GO:0030027	lamellipodium
0.49	GO:0030864	cortical actin cytoskeleton
0.49	GO:0043296	apical junction complex
0.49	GO:0098857	membrane microdomain
0.49	GO:0005802	trans-Golgi network
0.49	GO:0048471	perinuclear region of cytoplasm
0.47	GO:0098562	cytoplasmic side of membrane
0.47	GO:0019898	extrinsic component of membrane

sp|P22234|PUR6_HUMAN
Multifunctional protein ADE2
Search

PAICS

0.71	Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase

0.71	GO:0006189	'de novo' IMP biosynthetic process
0.39	GO:0043473	pigmentation
0.39	GO:0060041	retina development in camera-type eye
0.39	GO:0043009	chordate embryonic development
0.35	GO:0000082	G1/S transition of mitotic cell cycle
0.34	GO:0009113	purine nucleobase biosynthetic process

0.79	GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
0.48	GO:0045296	cadherin binding
0.45	GO:0042802	identical protein binding
0.39	GO:0004638	phosphoribosylaminoimidazole carboxylase activity
0.35	GO:0032555	purine ribonucleotide binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0030554	adenyl nucleotide binding
0.34	GO:0008144	drug binding
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding

0.37	GO:0005737	cytoplasm
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.79	EC:6.3.2.6	GO:0004639
0.79	KEGG:R04591	GO:0004639

sp|P22301|IL10_HUMAN
Interleukin-10
Search

IL10

0.91	Viral interleukin-10

0.75	GO:0010469	regulation of receptor activity
0.73	GO:0006955	immune response
0.63	GO:0002904	positive regulation of B cell apoptotic process
0.63	GO:0032800	receptor biosynthetic process
0.63	GO:0002740	negative regulation of cytokine secretion involved in immune response
0.62	GO:0051045	negative regulation of membrane protein ectodomain proteolysis
0.62	GO:0032715	negative regulation of interleukin-6 production
0.62	GO:0030889	negative regulation of B cell proliferation
0.60	GO:0051384	response to glucocorticoid
0.59	GO:0050715	positive regulation of cytokine secretion

0.80	GO:0005125	cytokine activity
0.43	GO:0005141	interleukin-10 receptor binding
0.34	GO:0008083	growth factor activity

0.66

GO:0005576

extracellular region

sp|P22303|ACES_HUMAN
Acetylcholinesterase
Search

ACHE

0.44	Carboxylic ester hydrolase

0.59	GO:0006581	acetylcholine catabolic process
0.56	GO:0045212	neurotransmitter receptor biosynthetic process
0.55	GO:0002076	osteoblast development
0.52	GO:0001919	regulation of receptor recycling
0.52	GO:0031623	receptor internalization
0.50	GO:0060041	retina development in camera-type eye
0.49	GO:0051262	protein tetramerization
0.47	GO:0007155	cell adhesion
0.43	GO:0071405	cellular response to methanol
0.42	GO:0050808	synapse organization

0.84	GO:0004104	cholinesterase activity
0.55	GO:0042166	acetylcholine binding
0.54	GO:0043236	laminin binding
0.52	GO:0005518	collagen binding
0.51	GO:0043621	protein self-association
0.51	GO:0042802	identical protein binding
0.46	GO:0046983	protein dimerization activity
0.45	GO:0017171	serine hydrolase activity
0.38	GO:0001540	amyloid-beta binding
0.36	GO:0033265	choline binding

0.52	GO:0005605	basal lamina
0.51	GO:0045202	synapse
0.50	GO:0048471	perinuclear region of cytoplasm
0.48	GO:0012505	endomembrane system
0.48	GO:0009986	cell surface
0.47	GO:0005615	extracellular space
0.42	GO:0043231	intracellular membrane-bounded organelle
0.42	GO:0030054	cell junction
0.42	GO:0031970	organelle envelope lumen
0.41	GO:0005886	plasma membrane

0.84

EC:3.1.1.8

GO:0004104

sp|P22304|IDS_HUMAN
Iduronate 2-sulfatase
Search

IDS

0.77	Iduronate 2-sulfatase

0.47	GO:0061316	canonical Wnt signaling pathway involved in heart development
0.46	GO:0060347	heart trabecula formation
0.46	GO:0060536	cartilage morphogenesis
0.45	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.44	GO:0007224	smoothened signaling pathway
0.43	GO:0043009	chordate embryonic development
0.36	GO:0030207	chondroitin sulfate catabolic process
0.32	GO:0048741	skeletal muscle fiber development

0.84	GO:0004423	iduronate-2-sulfatase activity
0.33	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.36	GO:0005764	lysosome
0.36	GO:0005775	vacuolar lumen
0.30	GO:0031224	intrinsic component of membrane

0.84

EC:3.1.6.13

GO:0004423

sp|P22307|NLTP_HUMAN
Non-specific lipid-transfer protein
Search

SCP2

0.60	Sterol carrier protein 2

0.61	GO:1901373	lipid hydroperoxide transport
0.60	GO:0032379	positive regulation of intracellular lipid transport
0.59	GO:0032380	regulation of intracellular sterol transport
0.58	GO:0032376	positive regulation of cholesterol transport
0.53	GO:0007031	peroxisome organization
0.45	GO:0015918	sterol transport
0.43	GO:0015914	phospholipid transport
0.43	GO:0006694	steroid biosynthetic process
0.40	GO:0032959	inositol trisphosphate biosynthetic process
0.39	GO:0042448	progesterone metabolic process

0.64	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
0.60	GO:0070538	oleic acid binding
0.59	GO:0036042	long-chain fatty acyl-CoA binding
0.56	GO:0032934	sterol binding
0.54	GO:0043178	alcohol binding
0.50	GO:0005102	receptor binding
0.46	GO:0015248	sterol transporter activity
0.39	GO:0008526	phosphatidylinositol transporter activity
0.37	GO:0005518	collagen binding
0.36	GO:1904121	phosphatidylethanolamine transporter activity

0.52	GO:0005777	peroxisome
0.48	GO:0005654	nucleoplasm
0.45	GO:0005739	mitochondrion
0.44	GO:0043234	protein complex
0.38	GO:0005615	extracellular space
0.37	GO:0031907	microbody lumen
0.36	GO:1903561	extracellular vesicle
0.36	GO:0031012	extracellular matrix
0.35	GO:0031312	extrinsic component of organelle membrane
0.34	GO:0031968	organelle outer membrane

0.64

GO:0016747

sp|P22309|UD11_HUMAN
UDP-glucuronosyltransferase 1-1
Search

0.54	UDP-glucuronosyltransferase

0.60	GO:0052695	cellular glucuronidation
0.56	GO:0009812	flavonoid metabolic process
0.52	GO:0006805	xenobiotic metabolic process
0.47	GO:2001030	negative regulation of cellular glucuronidation
0.45	GO:1904223	regulation of glucuronosyltransferase activity
0.44	GO:0043086	negative regulation of catalytic activity
0.42	GO:0045922	negative regulation of fatty acid metabolic process
0.42	GO:0042440	pigment metabolic process
0.42	GO:0031100	animal organ regeneration
0.42	GO:0001889	liver development

0.81	GO:0015020	glucuronosyltransferase activity
0.51	GO:0001972	retinoic acid binding
0.50	GO:0042803	protein homodimerization activity
0.49	GO:0046982	protein heterodimerization activity
0.46	GO:0019899	enzyme binding
0.45	GO:0005496	steroid binding
0.44	GO:0004857	enzyme inhibitor activity
0.39	GO:0005504	fatty acid binding
0.34	GO:0008144	drug binding
0.34	GO:0032403	protein complex binding

0.49	GO:0005783	endoplasmic reticulum
0.44	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.43	GO:0031984	organelle subcompartment
0.40	GO:0005887	integral component of plasma membrane
0.38	GO:0043234	protein complex
0.37	GO:0070062	extracellular exosome
0.33	GO:0031966	mitochondrial membrane
0.33	GO:0019866	organelle inner membrane

0.81

GO:0015020

sp|P22310|UD14_HUMAN
UDP-glucuronosyltransferase 1-4
Search

0.54	UDP-glucuronosyltransferase

0.59	GO:0052695	cellular glucuronidation
0.55	GO:0009812	flavonoid metabolic process
0.51	GO:0006805	xenobiotic metabolic process
0.46	GO:2001030	negative regulation of cellular glucuronidation
0.45	GO:1904223	regulation of glucuronosyltransferase activity
0.43	GO:0043086	negative regulation of catalytic activity
0.42	GO:0045922	negative regulation of fatty acid metabolic process
0.41	GO:0042440	pigment metabolic process
0.41	GO:0031100	animal organ regeneration
0.40	GO:0001889	liver development

0.80	GO:0015020	glucuronosyltransferase activity
0.50	GO:0001972	retinoic acid binding
0.48	GO:0042803	protein homodimerization activity
0.48	GO:0046982	protein heterodimerization activity
0.45	GO:0019899	enzyme binding
0.44	GO:0005496	steroid binding
0.42	GO:0004857	enzyme inhibitor activity
0.38	GO:0005504	fatty acid binding
0.34	GO:0008144	drug binding

0.48	GO:0005783	endoplasmic reticulum
0.44	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.43	GO:0031984	organelle subcompartment
0.39	GO:0005887	integral component of plasma membrane
0.37	GO:0043234	protein complex
0.35	GO:0070062	extracellular exosome
0.33	GO:0031966	mitochondrial membrane
0.33	GO:0019866	organelle inner membrane

0.80

GO:0015020

sp|P22314|UBA1_HUMAN
Ubiquitin-like modifier-activating enzyme 1
Search

UBA1

0.78	Ubiquitin activating enzyme

0.60	GO:0036211	protein modification process
0.55	GO:0044267	cellular protein metabolic process
0.47	GO:0006974	cellular response to DNA damage stimulus
0.44	GO:0043632	modification-dependent macromolecule catabolic process
0.44	GO:0007409	axonogenesis
0.43	GO:0030163	protein catabolic process
0.40	GO:0006508	proteolysis
0.36	GO:0007283	spermatogenesis

0.76	GO:0008641	ubiquitin-like modifier activating enzyme activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0016881	acid-amino acid ligase activity
0.35	GO:0003723	RNA binding
0.34	GO:0005515	protein binding
0.32	GO:0046872	metal ion binding

0.54	GO:0030057	desmosome
0.53	GO:0030867	rough endoplasmic reticulum membrane
0.52	GO:0000792	heterochromatin
0.52	GO:0005765	lysosomal membrane
0.51	GO:0010008	endosome membrane
0.48	GO:0005654	nucleoplasm
0.47	GO:0005829	cytosol
0.43	GO:0005739	mitochondrion
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.37

EC:6.3.2

GO:0016881

sp|P22352|GPX3_HUMAN
Glutathione peroxidase 3
Search

0.47	Epididymal secretory glutathione peroxidase

0.71	GO:0006979	response to oxidative stress
0.69	GO:0098869	cellular oxidant detoxification
0.53	GO:0051289	protein homotetramerization
0.52	GO:0055114	oxidation-reduction process
0.45	GO:0042744	hydrogen peroxide catabolic process
0.43	GO:0033554	cellular response to stress
0.36	GO:0010269	response to selenium ion
0.36	GO:0051412	response to corticosterone
0.36	GO:0002238	response to molecule of fungal origin
0.34	GO:0006749	glutathione metabolic process

0.79	GO:0004602	glutathione peroxidase activity
0.53	GO:0008430	selenium binding
0.34	GO:0008134	transcription factor binding

0.54	GO:0005615	extracellular space
0.53	GO:0097524	sperm plasma membrane
0.37	GO:1903561	extracellular vesicle
0.30	GO:0016021	integral component of membrane

0.79

EC:1.11.1.9

GO:0004602

sp|P22362|CCL1_HUMAN
C-C motif chemokine 1
Search

CCL1

0.65	C-C motif chemokine

0.82	GO:0060326	cell chemotaxis
0.74	GO:0090026	positive regulation of monocyte chemotaxis
0.74	GO:0006955	immune response
0.69	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.67	GO:0010469	regulation of receptor activity
0.57	GO:0072676	lymphocyte migration
0.56	GO:1990266	neutrophil migration
0.56	GO:0071347	cellular response to interleukin-1
0.55	GO:0071356	cellular response to tumor necrosis factor
0.55	GO:0070374	positive regulation of ERK1 and ERK2 cascade

0.84	GO:0008009	chemokine activity
0.57	GO:0048020	CCR chemokine receptor binding

0.68	GO:0005615	extracellular space
0.30	GO:0005623	cell

sp|P22392|NDKB_HUMAN
Nucleoside diphosphate kinase B
Search

0.47	Nucleoside diphosphate kinase B

0.78	GO:0006228	UTP biosynthetic process
0.78	GO:0006183	GTP biosynthetic process
0.75	GO:0046036	CTP metabolic process
0.70	GO:0006165	nucleoside diphosphate phosphorylation
0.48	GO:0042981	regulation of apoptotic process
0.47	GO:0050679	positive regulation of epithelial cell proliferation
0.45	GO:0007595	lactation
0.44	GO:0043388	positive regulation of DNA binding
0.44	GO:2000026	regulation of multicellular organismal development
0.42	GO:0045597	positive regulation of cell differentiation

0.78	GO:0004550	nucleoside diphosphate kinase activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0043024	ribosomal small subunit binding
0.41	GO:0042802	identical protein binding
0.41	GO:0019215	intermediate filament binding
0.41	GO:0004536	deoxyribonuclease activity
0.40	GO:0046872	metal ion binding

0.49	GO:0001726	ruffle
0.45	GO:0043209	myelin sheath
0.44	GO:0031256	leading edge membrane
0.43	GO:0030027	lamellipodium
0.43	GO:0031253	cell projection membrane
0.42	GO:0005634	nucleus
0.42	GO:0005829	cytosol
0.41	GO:0005925	focal adhesion
0.39	GO:0005739	mitochondrion
0.39	GO:0070062	extracellular exosome

0.78

EC:2.7.4.6

GO:0004550

sp|P22413|ENPP1_HUMAN
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Search

ENPP1

0.97	Ectonucleotide pyrophosphatase/phosphodiesterase 1

0.73	GO:0006955	immune response
0.71	GO:0006898	receptor-mediated endocytosis
0.61	GO:0030505	inorganic diphosphate transport
0.59	GO:0030730	sequestering of triglyceride
0.59	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
0.59	GO:0045719	negative regulation of glycogen biosynthetic process
0.59	GO:0031953	negative regulation of protein autophosphorylation
0.58	GO:0046325	negative regulation of glucose import
0.57	GO:0046627	negative regulation of insulin receptor signaling pathway
0.57	GO:0045599	negative regulation of fat cell differentiation

0.80	GO:0005044	scavenger receptor activity
0.77	GO:0030247	polysaccharide binding
0.60	GO:0004528	phosphodiesterase I activity
0.57	GO:0005158	insulin receptor binding
0.55	GO:0004551	nucleotide diphosphatase activity
0.54	GO:0047429	nucleoside-triphosphate diphosphatase activity
0.53	GO:0046872	metal ion binding
0.51	GO:0042803	protein homodimerization activity
0.50	GO:0003676	nucleic acid binding
0.42	GO:0030554	adenyl nucleotide binding

0.52	GO:0009986	cell surface
0.51	GO:0005615	extracellular space
0.43	GO:0048471	perinuclear region of cytoplasm
0.42	GO:0005886	plasma membrane
0.38	GO:0005765	lysosomal membrane
0.36	GO:0097441	basal dendrite
0.36	GO:0097440	apical dendrite
0.35	GO:0043025	neuronal cell body
0.34	GO:0045202	synapse
0.34	GO:1903561	extracellular vesicle

0.60

EC:3.1.4.1

GO:0004528

sp|P22415|USF1_HUMAN
Upstream stimulatory factor 1
Search

USF1

0.95	Upstream transcription factor 1 short form

0.61	GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose
0.58	GO:0019086	late viral transcription
0.55	GO:0055088	lipid homeostasis
0.54	GO:0032869	cellular response to insulin stimulus
0.53	GO:0009411	response to UV
0.53	GO:0001666	response to hypoxia
0.51	GO:0006366	transcription by RNA polymerase II
0.40	GO:0007595	lactation
0.38	GO:0006006	glucose metabolic process
0.36	GO:0051918	negative regulation of fibrinolysis

0.68	GO:0046983	protein dimerization activity
0.57	GO:0043425	bHLH transcription factor binding
0.56	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.54	GO:0042826	histone deacetylase binding
0.51	GO:0019901	protein kinase binding
0.51	GO:0042802	identical protein binding
0.47	GO:0043565	sequence-specific DNA binding
0.38	GO:0003690	double-stranded DNA binding

0.54	GO:0016589	NURF complex
0.52	GO:0048188	Set1C/COMPASS complex
0.50	GO:0005667	transcription factor complex

sp|P22455|FGFR4_HUMAN
Fibroblast growth factor receptor 4
Search

FGFR4

0.70	Fibroblast growth factor receptor

0.80	GO:0008543	fibroblast growth factor receptor signaling pathway
0.75	GO:0008284	positive regulation of cell proliferation
0.75	GO:0018108	peptidyl-tyrosine phosphorylation
0.59	GO:0070857	regulation of bile acid biosynthetic process
0.59	GO:0010715	regulation of extracellular matrix disassembly
0.59	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.57	GO:0046777	protein autophosphorylation
0.57	GO:2000573	positive regulation of DNA biosynthetic process
0.53	GO:0045862	positive regulation of proteolysis
0.53	GO:0016477	cell migration

0.84	GO:0005007	fibroblast growth factor-activated receptor activity
0.61	GO:0017134	fibroblast growth factor binding
0.55	GO:0008201	heparin binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0032555	purine ribonucleotide binding
0.41	GO:0042802	identical protein binding
0.38	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.37	GO:0098772	molecular function regulator

0.55	GO:0030133	transport vesicle
0.52	GO:0005911	cell-cell junction
0.52	GO:0005794	Golgi apparatus
0.52	GO:0005783	endoplasmic reticulum
0.50	GO:0005887	integral component of plasma membrane
0.41	GO:0005768	endosome
0.38	GO:0009986	cell surface
0.37	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0005764	lysosome
0.36	GO:0009898	cytoplasmic side of plasma membrane

0.38	EC:2.7.1.153	GO:0046934
0.38	KEGG:R04545	GO:0046934

sp|P22459|KCNA4_HUMAN
Potassium voltage-gated channel subfamily A member 4
Search

KCNA4

0.96	Potassium channel shaker alpha subunit pKv 1.4

0.76	GO:0051260	protein homooligomerization
0.75	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071805	potassium ion transmembrane transport

0.78	GO:0005249	voltage-gated potassium channel activity
0.66	GO:0030955	potassium ion binding
0.35	GO:0005515	protein binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.48	GO:0030424	axon
0.36	GO:0098889	intrinsic component of presynaptic membrane
0.36	GO:0045121	membrane raft
0.36	GO:0098936	intrinsic component of postsynaptic membrane
0.36	GO:0099699	integral component of synaptic membrane
0.35	GO:0043198	dendritic shaft
0.35	GO:0043197	dendritic spine
0.35	GO:0032279	asymmetric synapse
0.34	GO:0009986	cell surface

sp|P22460|KCNA5_HUMAN
Potassium voltage-gated channel subfamily A member 5
Search

KCNA5

0.90	Delayed rectifier K+ channel

0.77	GO:0051260	protein homooligomerization
0.77	GO:0034765	regulation of ion transmembrane transport
0.73	GO:0071804	cellular potassium ion transport
0.62	GO:0086052	membrane repolarization during SA node cell action potential
0.62	GO:0086050	membrane repolarization during bundle of His cell action potential
0.62	GO:0098662	inorganic cation transmembrane transport
0.61	GO:0099624	atrial cardiac muscle cell membrane repolarization
0.59	GO:0060081	membrane hyperpolarization
0.59	GO:0086014	atrial cardiac muscle cell action potential
0.58	GO:0086091	regulation of heart rate by cardiac conduction

0.78	GO:0005249	voltage-gated potassium channel activity
0.58	GO:0051393	alpha-actinin binding
0.58	GO:0097110	scaffold protein binding
0.57	GO:0019870	potassium channel inhibitor activity
0.53	GO:0019901	protein kinase binding
0.50	GO:0030955	potassium ion binding
0.37	GO:0005102	receptor binding

0.78	GO:0008076	voltage-gated potassium channel complex
0.57	GO:0014704	intercalated disc
0.54	GO:0045121	membrane raft
0.42	GO:0046691	intracellular canaliculus
0.39	GO:0030018	Z disc
0.38	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0030424	axon
0.37	GO:0005794	Golgi apparatus
0.37	GO:0005783	endoplasmic reticulum
0.36	GO:0043679	axon terminus

sp|P22466|GALA_HUMAN
Galanin peptides
Search

GAL

0.97	Galanin and GMAP prepropeptide

0.76	GO:0010469	regulation of receptor activity
0.64	GO:1902891	negative regulation of root hair elongation
0.63	GO:1902606	regulation of large conductance calcium-activated potassium channel activity
0.62	GO:0051795	positive regulation of timing of catagen
0.62	GO:0051464	positive regulation of cortisol secretion
0.61	GO:0010737	protein kinase A signaling
0.60	GO:1901018	positive regulation of potassium ion transmembrane transporter activity
0.59	GO:2001259	positive regulation of cation channel activity
0.59	GO:0007218	neuropeptide signaling pathway
0.58	GO:0019933	cAMP-mediated signaling

0.79	GO:0005179	hormone activity
0.66	GO:0031763	galanin receptor binding
0.62	GO:0004966	galanin receptor activity

0.66	GO:0005576	extracellular region
0.56	GO:0043025	neuronal cell body
0.49	GO:0030141	secretory granule
0.39	GO:0005794	Golgi apparatus
0.30	GO:0031224	intrinsic component of membrane

sp|P22492|H1T_HUMAN
Histone H1t
Search

0.97	Testicular H1 histone

0.79	GO:0006334	nucleosome assembly
0.52	GO:0098532	histone H3-K27 trimethylation
0.51	GO:0080182	histone H3-K4 trimethylation
0.50	GO:0016584	nucleosome positioning
0.48	GO:0000122	negative regulation of transcription by RNA polymerase II
0.46	GO:0007283	spermatogenesis
0.43	GO:0048260	positive regulation of receptor-mediated endocytosis
0.39	GO:0007275	multicellular organism development
0.39	GO:0030154	cell differentiation
0.38	GO:0071169	establishment of protein localization to chromatin

0.59	GO:0031490	chromatin DNA binding
0.42	GO:0008201	heparin binding
0.40	GO:0032564	dATP binding
0.38	GO:0003690	double-stranded DNA binding
0.38	GO:0005515	protein binding
0.37	GO:0016208	AMP binding
0.37	GO:0043531	ADP binding
0.36	GO:0005509	calcium ion binding
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0019001	guanyl nucleotide binding

0.75	GO:0000786	nucleosome
0.61	GO:0005634	nucleus
0.54	GO:0000791	euchromatin
0.51	GO:0031974	membrane-enclosed lumen
0.46	GO:0000792	heterochromatin
0.44	GO:0035327	transcriptionally active chromatin
0.41	GO:0031982	vesicle
0.40	GO:0009986	cell surface
0.37	GO:0043230	extracellular organelle
0.36	GO:0005615	extracellular space

sp|P22528|SPR1B_HUMAN
Cornifin-B
Search

0.93	Small proline rich protein 3

0.82	GO:0018149	peptide cross-linking
0.62	GO:0030216	keratinocyte differentiation
0.40	GO:0012501	programmed cell death
0.35	GO:0042060	wound healing
0.34	GO:0007010	cytoskeleton organization
0.34	GO:0030001	metal ion transport
0.34	GO:0008360	regulation of cell shape

0.48	GO:0005198	structural molecule activity
0.48	GO:0030674	protein binding, bridging
0.33	GO:0046872	metal ion binding

0.64	GO:0001533	cornified envelope
0.48	GO:0005737	cytoplasm
0.41	GO:0012505	endomembrane system
0.40	GO:0070062	extracellular exosome
0.38	GO:0043231	intracellular membrane-bounded organelle

sp|P22531|SPR2E_HUMAN
Small proline-rich protein 2E
Search

0.97	Small proline-rich protein 2E

0.58	GO:0018149	peptide cross-linking
0.58	GO:0008544	epidermis development
0.57	GO:0043588	skin development
0.55	GO:0030855	epithelial cell differentiation
0.46	GO:0032355	response to estradiol
0.41	GO:0012501	programmed cell death
0.37	GO:0008585	female gonad development
0.35	GO:0009411	response to UV
0.35	GO:0051258	protein polymerization
0.34	GO:0009664	plant-type cell wall organization

0.46	GO:0005198	structural molecule activity
0.36	GO:0005515	protein binding
0.34	GO:0060090	molecular adaptor activity
0.33	GO:0046872	metal ion binding
0.32	GO:0003676	nucleic acid binding
0.32	GO:0003700	DNA binding transcription factor activity

0.81	GO:0001533	cornified envelope
0.41	GO:0005737	cytoplasm
0.38	GO:0005634	nucleus
0.34	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

sp|P22532|SPR2D_HUMAN
Small proline-rich protein 2D
Search

0.97	Small proline-rich protein 2D

0.63	GO:0018149	peptide cross-linking
0.57	GO:0030216	keratinocyte differentiation
0.44	GO:0032355	response to estradiol
0.41	GO:0012501	programmed cell death
0.36	GO:0008585	female gonad development
0.35	GO:0009411	response to UV
0.34	GO:0051258	protein polymerization
0.33	GO:0007010	cytoskeleton organization
0.33	GO:0010054	trichoblast differentiation
0.33	GO:0008360	regulation of cell shape

0.46	GO:0005198	structural molecule activity
0.38	GO:0030674	protein binding, bridging
0.33	GO:0046983	protein dimerization activity
0.33	GO:0046872	metal ion binding
0.32	GO:0003676	nucleic acid binding

0.78	GO:0001533	cornified envelope
0.42	GO:0005737	cytoplasm
0.37	GO:0005634	nucleus
0.35	GO:0070062	extracellular exosome
0.34	GO:0012505	endomembrane system
0.33	GO:0009505	plant-type cell wall
0.33	GO:0055044	symplast
0.32	GO:0005911	cell-cell junction
0.32	GO:0036338	viral membrane
0.30	GO:0016021	integral component of membrane

sp|P22557|HEM0_HUMAN
5-aminolevulinate synthase, erythroid-specific, mitochondrial
Search

ALAS2

0.63	5-aminolevulinate synthase, erythroid-specific, mitochondrial

0.73	GO:0006782	protoporphyrinogen IX biosynthetic process
0.57	GO:0042541	hemoglobin biosynthetic process
0.56	GO:0001666	response to hypoxia
0.54	GO:0030218	erythrocyte differentiation
0.48	GO:0006879	cellular iron ion homeostasis
0.42	GO:0035162	embryonic hemopoiesis
0.41	GO:0061515	myeloid cell development
0.37	GO:0032025	response to cobalt ion
0.36	GO:1901423	response to benzene
0.36	GO:0032364	oxygen homeostasis

0.84	GO:0003870	5-aminolevulinate synthase activity
0.67	GO:0030170	pyridoxal phosphate binding
0.40	GO:0042802	identical protein binding
0.37	GO:0016594	glycine binding
0.33	GO:0016874	ligase activity

0.75	GO:0005759	mitochondrial matrix
0.46	GO:0031966	mitochondrial membrane
0.46	GO:0019866	organelle inner membrane
0.39	GO:0005829	cytosol
0.38	GO:0005654	nucleoplasm

0.84	EC:2.3.1.37	GO:0003870
0.84	KEGG:R00830	GO:0003870

sp|P22570|ADRO_HUMAN
NADPH:adrenodoxin oxidoreductase, mitochondrial
Search

FDXR

0.78	NADPH:adrenodoxin oxidoreductase, mitochondrial

0.52	GO:0055114	oxidation-reduction process
0.45	GO:0006744	ubiquinone biosynthetic process
0.41	GO:0008203	cholesterol metabolic process
0.37	GO:0006694	steroid biosynthetic process
0.36	GO:0008207	C21-steroid hormone metabolic process
0.36	GO:0006739	NADP metabolic process
0.35	GO:0042446	hormone biosynthetic process
0.33	GO:0006091	generation of precursor metabolites and energy

0.84	GO:0015039	NADPH-adrenodoxin reductase activity
0.37	GO:0004324	ferredoxin-NADP+ reductase activity
0.37	GO:0070402	NADPH binding
0.35	GO:0005515	protein binding
0.34	GO:0050660	flavin adenine dinucleotide binding

0.72	GO:0005759	mitochondrial matrix
0.44	GO:0031966	mitochondrial membrane
0.44	GO:0019866	organelle inner membrane

0.84

EC:1.18.1.6

GO:0015039

sp|P22607|FGFR3_HUMAN
Fibroblast growth factor receptor 3
Search

FGFR3

0.67	Fibroblast growth factor receptor

0.82	GO:0008543	fibroblast growth factor receptor signaling pathway
0.77	GO:0008284	positive regulation of cell proliferation
0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.57	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
0.56	GO:0010518	positive regulation of phospholipase activity
0.56	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
0.55	GO:0097191	extrinsic apoptotic signaling pathway
0.54	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.53	GO:0046777	protein autophosphorylation
0.43	GO:0070977	bone maturation

0.85	GO:0005007	fibroblast growth factor-activated receptor activity
0.56	GO:0017134	fibroblast growth factor binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0042802	identical protein binding
0.40	GO:0004908	interleukin-1 receptor activity
0.38	GO:0008083	growth factor activity
0.36	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity

0.52	GO:0030133	transport vesicle
0.49	GO:0005794	Golgi apparatus
0.48	GO:0005783	endoplasmic reticulum
0.47	GO:0005887	integral component of plasma membrane
0.40	GO:0048471	perinuclear region of cytoplasm
0.40	GO:0005764	lysosome
0.40	GO:0009986	cell surface
0.40	GO:0009898	cytoplasmic side of plasma membrane
0.37	GO:0005634	nucleus
0.35	GO:0005925	focal adhesion

0.36	EC:2.7.1.153	GO:0046934
0.36	KEGG:R04545	GO:0046934

sp|P22612|KAPCG_HUMAN
cAMP-dependent protein kinase catalytic subunit gamma
Search

0.89	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b

0.63

GO:0006468

protein phosphorylation

0.70	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.70

GO:0004674

sp|P22626|ROA2_HUMAN
Heterogeneous nuclear ribonucleoproteins A2/B1
Search

HNRNPA2B1

0.77	Heterogeneous nuclear ribonucleoprotein A2 homolog 1

0.79	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.75	GO:0051028	mRNA transport
0.74	GO:0006405	RNA export from nucleus
0.69	GO:0006397	mRNA processing
0.61	GO:1990428	miRNA transport
0.58	GO:0031053	primary miRNA processing
0.56	GO:0048025	negative regulation of mRNA splicing, via spliceosome
0.52	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
0.51	GO:0000122	negative regulation of transcription by RNA polymerase II
0.36	GO:1905661	regulation of telomerase RNA reverse transcriptase activity

0.59	GO:1990247	N6-methyladenosine-containing RNA binding
0.58	GO:0035198	miRNA binding
0.57	GO:0097157	pre-mRNA intronic binding
0.56	GO:0043047	single-stranded telomeric DNA binding
0.55	GO:0003730	mRNA 3'-UTR binding
0.35	GO:0042802	identical protein binding
0.35	GO:1990715	mRNA CDS binding
0.35	GO:0001069	regulatory region RNA binding
0.34	GO:0070182	DNA polymerase binding

0.59	GO:0019013	viral nucleocapsid
0.57	GO:0030529	intracellular ribonucleoprotein complex
0.54	GO:0070062	extracellular exosome
0.50	GO:0005654	nucleoplasm
0.45	GO:1902494	catalytic complex
0.39	GO:0005737	cytoplasm
0.35	GO:0016363	nuclear matrix
0.35	GO:0000781	chromosome, telomeric region
0.34	GO:0043204	perikaryon
0.33	GO:0043005	neuron projection

sp|P22670|RFX1_HUMAN
MHC class II regulatory factor RFX1
Search

RFX1

0.97	LOW QUALITY PROTEIN: MHC class II regulatory factor RFX1

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.44	GO:0006955	immune response
0.37	GO:0007368	determination of left/right symmetry
0.37	GO:0060284	regulation of cell development
0.36	GO:0072560	type B pancreatic cell maturation
0.36	GO:0120036	plasma membrane bounded cell projection organization
0.36	GO:2000026	regulation of multicellular organismal development
0.36	GO:0003351	epithelial cilium movement

0.55	GO:0003677	DNA binding
0.47	GO:0001067	regulatory region nucleic acid binding
0.42	GO:0003700	DNA binding transcription factor activity
0.36	GO:0005515	protein binding
0.34	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
0.34	GO:0004864	protein phosphatase inhibitor activity
0.34	GO:0004435	phosphatidylinositol phospholipase C activity

0.59	GO:0005634	nucleus
0.47	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.35	GO:0005694	chromosome
0.33	GO:0005737	cytoplasm
0.32	GO:0005667	transcription factor complex
0.30	GO:0031224	intrinsic component of membrane

0.34	EC:3.5	GO:0016810
0.34	KEGG:R03435	GO:0004435

sp|P22674|CCNO_HUMAN
Cyclin-O
Search

CCNO

0.97	Novel protein containing a Cyclin, N-terminal domain

0.71	GO:1903251	multi-ciliated epithelial cell differentiation
0.64	GO:0060271	cilium assembly
0.61	GO:0000278	mitotic cell cycle
0.59	GO:0006284	base-excision repair
0.41	GO:0042493	response to drug
0.40	GO:0051301	cell division
0.36	GO:0006275	regulation of DNA replication

0.64	GO:0097506	deaminated base DNA N-glycosylase activity
0.35	GO:0004386	helicase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005634	nucleus
0.55	GO:0031974	membrane-enclosed lumen
0.49	GO:0044446	intracellular organelle part
0.43	GO:0005737	cytoplasm

sp|P22676|CALB2_HUMAN
Calretinin
Search

0.83	Calretinin

0.65	GO:0055074	calcium ion homeostasis
0.51	GO:0072027	connecting tubule development
0.50	GO:0072221	metanephric distal convoluted tubule development
0.50	GO:0035502	metanephric part of ureteric bud development
0.50	GO:0072205	metanephric collecting duct development
0.49	GO:1900271	regulation of long-term synaptic potentiation
0.49	GO:0007614	short-term memory
0.49	GO:0010842	retina layer formation
0.48	GO:0007616	long-term memory
0.46	GO:0007626	locomotory behavior

0.70	GO:0005509	calcium ion binding
0.41	GO:0008270	zinc ion binding

0.49	GO:0043005	neuron projection
0.48	GO:0045202	synapse
0.46	GO:0043025	neuronal cell body
0.46	GO:0005829	cytosol
0.45	GO:0120038	plasma membrane bounded cell projection part
0.43	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane
0.30	GO:0005921	gap junction

sp|P22680|CP7A1_HUMAN
Cholesterol 7-alpha-monooxygenase
Search

CYP7A1

0.97	Cholesterol 7-alpha-monooxygenase

0.85	GO:0006707	cholesterol catabolic process
0.85	GO:0006699	bile acid biosynthetic process
0.84	GO:0071333	cellular response to glucose stimulus
0.83	GO:0042632	cholesterol homeostasis
0.60	GO:0070857	regulation of bile acid biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.43	GO:0071397	cellular response to cholesterol
0.35	GO:1904253	positive regulation of bile acid metabolic process
0.35	GO:0010893	positive regulation of steroid biosynthetic process
0.34	GO:0031328	positive regulation of cellular biosynthetic process

0.86	GO:0008123	cholesterol 7-alpha-monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.37	GO:0008397	sterol 12-alpha-hydroxylase activity
0.33	GO:0015002	heme-copper terminal oxidase activity
0.33	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.33	GO:0015078	hydrogen ion transmembrane transporter activity
0.33	GO:0009055	electron transfer activity

0.65	GO:0005789	endoplasmic reticulum membrane
0.37	GO:0031090	organelle membrane
0.33	GO:0005740	mitochondrial envelope
0.30	GO:0031224	intrinsic component of membrane

0.86

EC:1.14.13.17

GO:0008123

sp|P22681|CBL_HUMAN
E3 ubiquitin-protein ligase CBL
Search

CBL

0.94	Tyrosine kinase negative regulator Cbl

0.72	GO:0016567	protein ubiquitination
0.70	GO:0007166	cell surface receptor signaling pathway
0.69	GO:0023051	regulation of signaling
0.57	GO:0048260	positive regulation of receptor-mediated endocytosis
0.53	GO:0043066	negative regulation of apoptotic process
0.52	GO:0010648	negative regulation of cell communication
0.51	GO:0010647	positive regulation of cell communication
0.51	GO:0048584	positive regulation of response to stimulus
0.51	GO:0048585	negative regulation of response to stimulus
0.50	GO:0006511	ubiquitin-dependent protein catabolic process

0.85	GO:0001784	phosphotyrosine residue binding
0.73	GO:0004842	ubiquitin-protein transferase activity
0.69	GO:0005509	calcium ion binding
0.63	GO:0004871	signal transducer activity
0.56	GO:0046875	ephrin receptor binding
0.55	GO:0017124	SH3 domain binding
0.54	GO:0045296	cadherin binding
0.52	GO:0016874	ligase activity
0.49	GO:0030971	receptor tyrosine kinase binding
0.46	GO:0061659	ubiquitin-like protein ligase activity

0.60	GO:0005634	nucleus
0.58	GO:0016600	flotillin complex
0.49	GO:0005829	cytosol
0.39	GO:0030426	growth cone
0.39	GO:0005925	focal adhesion
0.39	GO:0030424	axon
0.38	GO:0048471	perinuclear region of cytoplasm
0.38	GO:0042629	mast cell granule
0.33	GO:0070013	intracellular organelle lumen
0.33	GO:0042025	host cell nucleus

0.52	EC:6	GO:0016874
0.73	KEGG:R03876	GO:0004842

sp|P22692|IBP4_HUMAN
Insulin-like growth factor-binding protein 4
Search

IGFBP4

0.97	Insulin like growth factor binding protein 4

0.77	GO:0001558	regulation of cell growth
0.62	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway
0.61	GO:0044342	type B pancreatic cell proliferation
0.57	GO:0010906	regulation of glucose metabolic process
0.55	GO:0043410	positive regulation of MAPK cascade
0.42	GO:0042127	regulation of cell proliferation
0.39	GO:0006954	inflammatory response
0.39	GO:0014912	negative regulation of smooth muscle cell migration
0.39	GO:0045663	positive regulation of myoblast differentiation
0.38	GO:0032868	response to insulin

0.84	GO:0005520	insulin-like growth factor binding
0.40	GO:0008160	protein tyrosine phosphatase activator activity
0.38	GO:0001968	fibronectin binding
0.35	GO:0005102	receptor binding
0.31	GO:0046872	metal ion binding

0.66	GO:0005576	extracellular region
0.40	GO:0036454	growth factor complex
0.36	GO:0005788	endoplasmic reticulum lumen
0.35	GO:0005634	nucleus
0.33	GO:0031982	vesicle
0.32	GO:0016324	apical plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P22694|KAPCB_HUMAN
cAMP-dependent protein kinase catalytic subunit beta
Search

PRKACB

0.95	cAMP-dependent protein kinase catalytic subunit beta

0.61	GO:0006468	protein phosphorylation
0.59	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
0.55	GO:0001843	neural tube closure
0.55	GO:0070613	regulation of protein processing
0.48	GO:0071374	cellular response to parathyroid hormone stimulus
0.48	GO:2000810	regulation of bicellular tight junction assembly
0.47	GO:0048240	sperm capacitation
0.47	GO:0071158	positive regulation of cell cycle arrest
0.47	GO:0034605	cellular response to heat
0.47	GO:0071333	cellular response to glucose stimulus

0.67	GO:0004674	protein serine/threonine kinase activity
0.53	GO:0031625	ubiquitin protein ligase binding
0.53	GO:0030554	adenyl nucleotide binding
0.52	GO:0097367	carbohydrate derivative binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0034237	protein kinase A regulatory subunit binding
0.48	GO:0060089	molecular transducer activity
0.46	GO:0000287	magnesium ion binding
0.45	GO:0004712	protein serine/threonine/tyrosine kinase activity

0.57	GO:0097546	ciliary base
0.56	GO:0045171	intercellular bridge
0.52	GO:0005813	centrosome
0.49	GO:0005829	cytosol
0.48	GO:0005952	cAMP-dependent protein kinase complex
0.48	GO:0036126	sperm flagellum
0.48	GO:0001669	acrosomal vesicle
0.48	GO:0048471	perinuclear region of cytoplasm
0.46	GO:0044853	plasma membrane raft
0.46	GO:0043197	dendritic spine

0.67

GO:0004674

sp|P22695|QCR2_HUMAN
Cytochrome b-c1 complex subunit 2, mitochondrial
Search

UQCRC2

0.82	Ubiquinol-cytochrome c reductase core protein II

0.51	GO:0006627	protein processing involved in protein targeting to mitochondrion
0.34	GO:0022900	electron transport chain

0.57	GO:0004222	metalloendopeptidase activity
0.54	GO:0046872	metal ion binding
0.36	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
0.34	GO:0009055	electron transfer activity

0.59	GO:0005750	mitochondrial respiratory chain complex III
0.58	GO:0005751	mitochondrial respiratory chain complex IV
0.58	GO:0043209	myelin sheath
0.51	GO:0005654	nucleoplasm

0.57

GO:0004222

sp|P22732|GTR5_HUMAN
Solute carrier family 2, facilitated glucose transporter member 5
Search

SLC2A5

0.93	Solute carrier family 2, facilitated glucose transporter member 5

0.62	GO:0015755	fructose transport
0.57	GO:0071332	cellular response to fructose stimulus
0.57	GO:0098704	carbohydrate import across plasma membrane
0.52	GO:0003044	regulation of systemic arterial blood pressure mediated by a chemical signal
0.51	GO:1905950	monosaccharide transmembrane transport
0.37	GO:0015758	glucose transport
0.36	GO:0106001	intestinal hexose absorption
0.36	GO:0043312	neutrophil degranulation
0.33	GO:0005975	carbohydrate metabolic process

0.62	GO:0005353	fructose transmembrane transporter activity
0.43	GO:0070061	fructose binding
0.37	GO:0005355	glucose transmembrane transporter activity

0.51	GO:0016324	apical plasma membrane
0.45	GO:0005887	integral component of plasma membrane
0.43	GO:0042383	sarcolemma
0.37	GO:0070062	extracellular exosome
0.36	GO:0035579	specific granule membrane

sp|P22735|TGM1_HUMAN
Protein-glutamine gamma-glutamyltransferase K
Search

TGM1

0.97	Glutamine gamma-glutamyltransferase K

0.84	GO:0018149	peptide cross-linking
0.62	GO:0010838	positive regulation of keratinocyte proliferation
0.59	GO:0030216	keratinocyte differentiation
0.55	GO:0045787	positive regulation of cell cycle
0.37	GO:0009887	animal organ morphogenesis
0.36	GO:0043163	cell envelope organization
0.35	GO:0012501	programmed cell death
0.34	GO:0051262	protein tetramerization
0.34	GO:0072378	blood coagulation, fibrin clot formation
0.33	GO:0098869	cellular oxidant detoxification

0.84	GO:0003810	protein-glutamine gamma-glutamyltransferase activity
0.36	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding
0.33	GO:0004096	catalase activity
0.32	GO:0020037	heme binding
0.32	GO:0003677	DNA binding

0.38	GO:0005913	cell-cell adherens junction
0.38	GO:0070062	extracellular exosome
0.36	GO:0001533	cornified envelope
0.34	GO:0005829	cytosol
0.34	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.30	GO:0016021	integral component of membrane

0.84

EC:2.3.2.13

GO:0003810

sp|P22736|NR4A1_HUMAN
Nuclear receptor subfamily 4 group A member 1
Search

NR4A1

0.95	Orphan nuclear receptor HMR

0.80	GO:0030522	intracellular receptor signaling pathway
0.78	GO:0043401	steroid hormone mediated signaling pathway
0.64	GO:0071376	cellular response to corticotropin-releasing hormone stimulus
0.60	GO:0045444	fat cell differentiation
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0043066	negative regulation of apoptotic process
0.55	GO:0035914	skeletal muscle cell differentiation

0.82	GO:0004879	nuclear receptor activity
0.80	GO:0003707	steroid hormone receptor activity
0.64	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.58	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.54	GO:0046982	protein heterodimerization activity
0.51	GO:0035259	glucocorticoid receptor binding
0.50	GO:0042803	protein homodimerization activity
0.44	GO:0001012	RNA polymerase II regulatory region DNA binding
0.42	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.50	GO:0005667	transcription factor complex
0.49	GO:0005829	cytosol
0.48	GO:0012505	endomembrane system
0.46	GO:0044446	intracellular organelle part
0.45	GO:0031090	organelle membrane
0.45	GO:0031975	envelope
0.42	GO:0070013	intracellular organelle lumen

sp|P22748|CAH4_HUMAN
Carbonic anhydrase 4
Search

CA4

0.42	Carbonic anhydrase IV a

0.68	GO:0006730	one-carbon metabolic process
0.58	GO:0015701	bicarbonate transport
0.36	GO:0015670	carbon dioxide transport
0.36	GO:0006885	regulation of pH
0.35	GO:0048545	response to steroid hormone
0.35	GO:0032501	multicellular organismal process
0.34	GO:0035813	regulation of renal sodium excretion
0.34	GO:0048856	anatomical structure development
0.34	GO:0035335	peptidyl-tyrosine dephosphorylation
0.34	GO:0050878	regulation of body fluid levels

0.76	GO:0004089	carbonate dehydratase activity
0.62	GO:0008270	zinc ion binding
0.36	GO:0005515	protein binding
0.34	GO:0004725	protein tyrosine phosphatase activity

0.70	GO:0031225	anchored component of membrane
0.58	GO:0031233	intrinsic component of external side of plasma membrane
0.57	GO:0031526	brush border membrane
0.56	GO:0030667	secretory granule membrane
0.56	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.55	GO:0005791	rough endoplasmic reticulum
0.55	GO:0016324	apical plasma membrane
0.54	GO:0070062	extracellular exosome
0.54	GO:0005802	trans-Golgi network
0.54	GO:0048471	perinuclear region of cytoplasm

0.76

GO:0004089

sp|P22749|GNLY_HUMAN
Granulysin
Search

GNLY

0.97	Granulysin

0.90	GO:0002818	intracellular defense response
0.86	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
0.83	GO:0050832	defense response to fungus
0.79	GO:0031640	killing of cells of other organism
0.78	GO:0042742	defense response to bacterium

0.89	GO:0097013	phagocytic vesicle lumen
0.87	GO:0044194	cytolytic granule
0.73	GO:0005615	extracellular space

sp|P22760|AAAD_HUMAN
Arylacetamide deacetylase
Search

AADAC

0.91	Arylacetamide deacetylase

0.53	GO:0010898	positive regulation of triglyceride catabolic process
0.44	GO:0009056	catabolic process
0.39	GO:0006805	xenobiotic metabolic process
0.37	GO:0060395	SMAD protein signal transduction
0.36	GO:0006470	protein dephosphorylation
0.33	GO:0006629	lipid metabolic process
0.32	GO:0032392	DNA geometric change
0.32	GO:0006260	DNA replication

0.68	GO:0052689	carboxylic ester hydrolase activity
0.48	GO:0016298	lipase activity
0.47	GO:0019213	deacetylase activity
0.46	GO:0017171	serine hydrolase activity
0.36	GO:0042301	phosphate ion binding
0.32	GO:0003678	DNA helicase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.47	GO:0005789	endoplasmic reticulum membrane
0.36	GO:0031090	organelle membrane
0.33	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

0.68	EC:3.1.1 EC:3.1.1.1	GO:0052689
0.68	KEGG:R00630	GO:0052689

sp|P22792|CPN2_HUMAN
Carboxypeptidase N subunit 2
Search

CPN2

0.85	Carboxypeptidase N subunit 2

0.55	GO:0006508	proteolysis
0.45	GO:0048731	system development
0.44	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.44	GO:0000904	cell morphogenesis involved in differentiation
0.43	GO:0120036	plasma membrane bounded cell projection organization
0.41	GO:0022602	ovulation cycle process
0.41	GO:0046545	development of primary female sexual characteristics
0.40	GO:0022412	cellular process involved in reproduction in multicellular organism
0.38	GO:0007186	G-protein coupled receptor signaling pathway
0.37	GO:0006468	protein phosphorylation

0.64	GO:0004180	carboxypeptidase activity
0.42	GO:0004963	follicle-stimulating hormone receptor activity
0.37	GO:0004672	protein kinase activity
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.30	GO:0008237	metallopeptidase activity
0.30	GO:0098772	molecular function regulator

0.44	GO:0005576	extracellular region
0.39	GO:0031982	vesicle
0.30	GO:0016020	membrane

sp|P22794|EVI2A_HUMAN
Protein EVI2A
Search

EVI2A

0.92	Ecotropic viral integration site 2A

0.30

GO:0044425

membrane part

sp|P22830|HEMH_HUMAN
Ferrochelatase, mitochondrial
Search

FECH

0.55	Ferrochelatase

0.71	GO:0006783	heme biosynthetic process
0.49	GO:0046501	protoporphyrinogen IX metabolic process
0.39	GO:0030218	erythrocyte differentiation
0.38	GO:0070541	response to platinum ion
0.38	GO:0010288	response to lead ion
0.38	GO:0061515	myeloid cell development
0.38	GO:0051597	response to methylmercury
0.38	GO:0017085	response to insecticide
0.37	GO:0071549	cellular response to dexamethasone stimulus
0.37	GO:0071695	anatomical structure maturation

0.76	GO:0004325	ferrochelatase activity
0.36	GO:0030350	iron-responsive element binding
0.33	GO:0020037	heme binding
0.33	GO:0005506	iron ion binding
0.32	GO:0005509	calcium ion binding

0.39	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.76	EC:4.99.1.1	GO:0004325
0.76	KEGG:R00310	GO:0004325

sp|P22888|LSHR_HUMAN
Lutropin-choriogonadotropic hormone receptor
Search

LHCGR

0.79	Lutropin-choriogonadotropic hormone receptor

0.80	GO:0042700	luteinizing hormone signaling pathway
0.69	GO:0001541	ovarian follicle development
0.63	GO:0071371	cellular response to gonadotropin stimulus
0.62	GO:0007190	activation of adenylate cyclase activity
0.62	GO:0032962	positive regulation of inositol trisphosphate biosynthetic process
0.62	GO:0046544	development of secondary male sexual characteristics
0.61	GO:0060065	uterus development
0.60	GO:0008584	male gonad development
0.60	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
0.60	GO:0090030	regulation of steroid hormone biosynthetic process

0.84	GO:0016500	protein-hormone receptor activity
0.71	GO:0004930	G-protein coupled receptor activity
0.63	GO:0038106	choriogonadotropin hormone binding
0.48	GO:0001653	peptide receptor activity
0.36	GO:0017046	peptide hormone binding
0.36	GO:0051117	ATPase binding
0.35	GO:0042803	protein homodimerization activity

0.53	GO:0005886	plasma membrane
0.40	GO:0009986	cell surface
0.38	GO:0005622	intracellular
0.37	GO:0031982	vesicle
0.36	GO:0012505	endomembrane system
0.35	GO:0043235	receptor complex
0.35	GO:0098552	side of membrane
0.35	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane

sp|P22891|PROZ_HUMAN
Vitamin K-dependent protein Z
Search

PROZ

0.97	Vitamin K-dependent protein Z

0.73	GO:0007596	blood coagulation
0.57	GO:0006508	proteolysis
0.53	GO:0030195	negative regulation of blood coagulation
0.41	GO:1900141	regulation of oligodendrocyte apoptotic process
0.41	GO:0097241	hematopoietic stem cell migration to bone marrow
0.41	GO:0071307	cellular response to vitamin K
0.41	GO:0033159	negative regulation of protein import into nucleus, translocation
0.41	GO:2000669	negative regulation of dendritic cell apoptotic process
0.41	GO:0035754	B cell chemotaxis
0.40	GO:1900165	negative regulation of interleukin-6 secretion

0.70	GO:0005509	calcium ion binding
0.64	GO:0004252	serine-type endopeptidase activity
0.40	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.40	GO:0030296	protein tyrosine kinase activator activity
0.40	GO:0001786	phosphatidylserine binding
0.39	GO:0030971	receptor tyrosine kinase binding
0.39	GO:0005245	voltage-gated calcium channel activity
0.38	GO:0060090	molecular adaptor activity
0.38	GO:0048018	receptor ligand activity
0.35	GO:0004872	receptor activity

0.65	GO:0005576	extracellular region
0.39	GO:0031982	vesicle
0.39	GO:0005796	Golgi lumen
0.38	GO:0005788	endoplasmic reticulum lumen
0.35	GO:0009986	cell surface
0.32	GO:0000139	Golgi membrane
0.32	GO:0005789	endoplasmic reticulum membrane
0.32	GO:0005634	nucleus
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.64

GO:0004252

sp|P22894|MMP8_HUMAN
Neutrophil collagenase
Search

MMP8

0.71	Matrix metalloproteinase

0.61	GO:0006508	proteolysis
0.56	GO:0035987	endodermal cell differentiation
0.46	GO:0030574	collagen catabolic process
0.45	GO:0032461	positive regulation of protein oligomerization
0.41	GO:0022617	extracellular matrix disassembly
0.38	GO:0001503	ossification
0.38	GO:0060349	bone morphogenesis
0.38	GO:0016477	cell migration
0.37	GO:0002376	immune system process
0.37	GO:0003416	endochondral bone growth

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.48	GO:0004252	serine-type endopeptidase activity
0.38	GO:0005518	collagen binding
0.37	GO:0005509	calcium ion binding
0.34	GO:0001047	core promoter binding
0.33	GO:0043565	sequence-specific DNA binding

0.74	GO:0031012	extracellular matrix
0.50	GO:0005615	extracellular space
0.40	GO:0005581	collagen trimer
0.37	GO:1904724	tertiary granule lumen
0.37	GO:0035580	specific granule lumen
0.33	GO:0005634	nucleus

0.70

GO:0004222

sp|P22897|MRC1_HUMAN
Macrophage mannose receptor 1
Search

0.64	macrophage mannose receptor 1

0.50	GO:0071353	cellular response to interleukin-4
0.49	GO:0071346	cellular response to interferon-gamma
0.48	GO:0071222	cellular response to lipopolysaccharide
0.44	GO:0006898	receptor-mediated endocytosis
0.44	GO:0007165	signal transduction
0.30	GO:0016032	viral process
0.30	GO:0051806	entry into cell of other organism involved in symbiotic interaction
0.30	GO:0044409	entry into host

0.49	GO:0005537	mannose binding
0.48	GO:0004888	transmembrane signaling receptor activity
0.30	GO:0005515	protein binding
0.30	GO:0001618	virus receptor activity

0.47	GO:0005887	integral component of plasma membrane
0.46	GO:0010008	endosome membrane
0.46	GO:0009986	cell surface

sp|P22914|CRBS_HUMAN
Beta-crystallin S
Search

CRYGS

0.96	Gamma-crystallin S

0.81	GO:0002088	lens development in camera-type eye
0.71	GO:0060429	epithelium development
0.70	GO:0048729	tissue morphogenesis
0.49	GO:0007601	visual perception
0.42	GO:0030154	cell differentiation
0.41	GO:0034614	cellular response to reactive oxygen species
0.36	GO:0048593	camera-type eye morphogenesis
0.35	GO:0000902	cell morphogenesis

0.84	GO:0005212	structural constituent of eye lens
0.35	GO:0005515	protein binding

0.42	GO:0005634	nucleus
0.37	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|P23025|XPA_HUMAN
DNA repair protein complementing XP-A cells
Search

XPA

0.96	DNA repair protein complementing XP-A cells

0.73	GO:0006289	nucleotide-excision repair
0.60	GO:0009650	UV protection
0.57	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
0.57	GO:0035264	multicellular organism growth
0.55	GO:0034504	protein localization to nucleus
0.50	GO:0006979	response to oxidative stress
0.49	GO:0070914	UV-damage excision repair
0.48	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.48	GO:0009636	response to toxic substance
0.47	GO:0036297	interstrand cross-link repair

0.73	GO:0003684	damaged DNA binding
0.53	GO:0019904	protein domain specific binding
0.53	GO:0042803	protein homodimerization activity
0.35	GO:0046872	metal ion binding
0.34	GO:0003690	double-stranded DNA binding
0.34	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity

0.61	GO:0005634	nucleus
0.58	GO:0045171	intercellular bridge
0.53	GO:0030894	replisome
0.49	GO:0031974	membrane-enclosed lumen
0.46	GO:0043234	protein complex
0.45	GO:1990391	DNA repair complex
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.34

EC:2.3.1.51

GO:0003841

sp|P23083|HV102_HUMAN
Immunoglobulin heavy variable 1-2
Search

0.50	Immunoglobulin heavy variable 1-2

0.81	GO:0006958	complement activation, classical pathway
0.79	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.78	GO:0006909	phagocytosis
0.74	GO:0099024	plasma membrane invagination
0.73	GO:0050871	positive regulation of B cell activation
0.69	GO:0008037	cell recognition
0.68	GO:0045087	innate immune response
0.67	GO:0042742	defense response to bacterium
0.58	GO:0038094	Fc-gamma receptor signaling pathway
0.58	GO:0038095	Fc-epsilon receptor signaling pathway

0.82	GO:0003823	antigen binding
0.76	GO:0034987	immunoglobulin receptor binding
0.48	GO:0004252	serine-type endopeptidase activity

0.75	GO:0042571	immunoglobulin complex, circulating
0.74	GO:0072562	blood microparticle
0.70	GO:0009897	external side of plasma membrane
0.38	GO:0005887	integral component of plasma membrane

0.48

GO:0004252

sp|P23109|AMPD1_HUMAN
AMP deaminase 1
Search

AMPD1

0.74	Adenosine monophosphate deaminase 1

0.79	GO:0032264	IMP salvage
0.43	GO:0097009	energy homeostasis
0.42	GO:0034101	erythrocyte homeostasis
0.40	GO:0046039	GTP metabolic process
0.40	GO:0046033	AMP metabolic process
0.39	GO:0046031	ADP metabolic process
0.37	GO:0046034	ATP metabolic process
0.36	GO:0010033	response to organic substance
0.33	GO:0007165	signal transduction

0.84	GO:0003876	AMP deaminase activity
0.50	GO:0046872	metal ion binding
0.39	GO:0032036	myosin heavy chain binding
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0032561	guanyl ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.84

EC:3.5.4.6

GO:0003876

sp|P23141|EST1_HUMAN
Liver carboxylesterase 1
Search

0.52	Liver carboxylesterase

0.57	GO:0051791	medium-chain fatty acid metabolic process
0.56	GO:0034377	plasma lipoprotein particle assembly
0.55	GO:0006695	cholesterol biosynthetic process
0.52	GO:0030855	epithelial cell differentiation
0.51	GO:0019626	short-chain fatty acid catabolic process
0.51	GO:0046464	acylglycerol catabolic process
0.50	GO:0090122	cholesterol ester hydrolysis involved in cholesterol transport
0.47	GO:0090320	regulation of chylomicron remnant clearance
0.44	GO:0009636	response to toxic substance
0.44	GO:0090207	regulation of triglyceride metabolic process

0.70	GO:0052689	carboxylic ester hydrolase activity
0.50	GO:0016298	lipase activity
0.45	GO:0016290	palmitoyl-CoA hydrolase activity
0.43	GO:0019213	deacetylase activity

0.77	GO:0005788	endoplasmic reticulum lumen
0.52	GO:0005811	lipid droplet
0.50	GO:0005829	cytosol
0.41	GO:0005576	extracellular region

0.70	EC:3.1.1 EC:3.1.1.1	GO:0052689
0.70	KEGG:R00630	GO:0052689

sp|P23142|FBLN1_HUMAN
Fibulin-1
Search

FBLN1

0.73

Fibulin-1

0.80	GO:0010952	positive regulation of peptidase activity
0.78	GO:0030198	extracellular matrix organization
0.61	GO:0072378	blood coagulation, fibrin clot formation
0.61	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
0.60	GO:2000647	negative regulation of stem cell proliferation
0.59	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.57	GO:2000146	negative regulation of cell motility
0.42	GO:1904188	negative regulation of transformation of host cell by virus
0.42	GO:1904237	positive regulation of substrate-dependent cell migration, cell attachment to substrate
0.42	GO:2001202	negative regulation of transforming growth factor-beta secretion

0.82	GO:0016504	peptidase activator activity
0.70	GO:0005509	calcium ion binding
0.63	GO:0070051	fibrinogen binding
0.61	GO:0001968	fibronectin binding
0.57	GO:0008022	protein C-terminus binding
0.57	GO:0005201	extracellular matrix structural constituent
0.53	GO:0042802	identical protein binding
0.43	GO:0005178	integrin binding

0.69	GO:0005578	proteinaceous extracellular matrix
0.62	GO:0071953	elastic fiber
0.60	GO:0005577	fibrinogen complex
0.39	GO:0070062	extracellular exosome
0.33	GO:0005622	intracellular

sp|P23193|TCEA1_HUMAN
Transcription elongation factor A protein 1
Search

TCEA1

0.96	Transcription elongation factor A protein 1

0.62	GO:0006414	translational elongation
0.57	GO:0006351	transcription, DNA-templated
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.41	GO:1901919	positive regulation of exoribonuclease activity
0.35	GO:0030218	erythrocyte differentiation
0.35	GO:0006283	transcription-coupled nucleotide-excision repair
0.34	GO:0010557	positive regulation of macromolecule biosynthetic process
0.34	GO:0031328	positive regulation of cellular biosynthetic process

0.62	GO:0003746	translation elongation factor activity
0.62	GO:0008270	zinc ion binding
0.35	GO:0003677	DNA binding
0.35	GO:0005515	protein binding
0.32	GO:0016787	hydrolase activity

0.61	GO:0005634	nucleus
0.50	GO:0000428	DNA-directed RNA polymerase complex
0.50	GO:0005667	transcription factor complex
0.46	GO:0031974	membrane-enclosed lumen
0.43	GO:0043232	intracellular non-membrane-bounded organelle
0.42	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016787

sp|P23219|PGH1_HUMAN
Prostaglandin G/H synthase 1
Search

PTGS1

0.96	Prostaglandin-endoperoxide synthase 1 (Prostaglandin G/H synthase and cyclooxygenase)

0.86	GO:0019371	cyclooxygenase pathway
0.83	GO:0008217	regulation of blood pressure
0.80	GO:0006954	inflammatory response
0.71	GO:0006979	response to oxidative stress
0.69	GO:0098869	cellular oxidant detoxification
0.53	GO:0055114	oxidation-reduction process
0.50	GO:0042127	regulation of cell proliferation
0.39	GO:1990402	embryonic liver development
0.39	GO:0071471	cellular response to non-ionic osmotic stress
0.39	GO:0031394	positive regulation of prostaglandin biosynthetic process

0.86	GO:0004666	prostaglandin-endoperoxide synthase activity
0.72	GO:0004601	peroxidase activity
0.63	GO:0020037	heme binding
0.40	GO:0051213	dioxygenase activity
0.37	GO:0042803	protein homodimerization activity
0.37	GO:0019899	enzyme binding
0.36	GO:0046872	metal ion binding
0.32	GO:0008144	drug binding

0.53	GO:0001750	photoreceptor outer segment
0.48	GO:0012505	endomembrane system
0.42	GO:0043231	intracellular membrane-bounded organelle
0.42	GO:0044444	cytoplasmic part
0.39	GO:0031984	organelle subcompartment
0.38	GO:0031090	organelle membrane
0.36	GO:0070062	extracellular exosome
0.33	GO:0031967	organelle envelope
0.30	GO:0016021	integral component of membrane

0.86	EC:1.14.99.1	GO:0004666
0.72	KEGG:R03532	GO:0004601

sp|P23229|ITA6_HUMAN
Integrin alpha-6
Search

ITGA6

0.95	Integrin subunit alpha 6

0.77	GO:0007229	integrin-mediated signaling pathway
0.69	GO:0007155	cell adhesion
0.60	GO:0010668	ectodermal cell differentiation
0.59	GO:0035878	nail development
0.59	GO:0046847	filopodium assembly
0.58	GO:0097186	amelogenesis
0.57	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
0.57	GO:0050873	brown fat cell differentiation
0.56	GO:0043588	skin development
0.56	GO:0048565	digestive tract development

0.61	GO:0038132	neuregulin binding
0.59	GO:0031994	insulin-like growth factor I binding
0.56	GO:0005178	integrin binding
0.55	GO:0045296	cadherin binding
0.41	GO:0043236	laminin binding
0.34	GO:0046872	metal ion binding

0.78	GO:0008305	integrin complex
0.59	GO:0030056	hemidesmosome
0.58	GO:0009925	basal plasma membrane
0.55	GO:0005604	basement membrane
0.55	GO:0009897	external side of plasma membrane
0.40	GO:0030175	filopodium
0.40	GO:0005913	cell-cell adherens junction
0.39	GO:0005925	focal adhesion

sp|P23246|SFPQ_HUMAN
Splicing factor, proline- and glutamine-rich
Search

SFPQ

0.96	Splicing factor proline and glutamine rich

0.55	GO:0000380	alternative mRNA splicing, via spliceosome
0.55	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
0.53	GO:0045876	positive regulation of sister chromatid cohesion
0.52	GO:0042754	negative regulation of circadian rhythm
0.51	GO:0002218	activation of innate immune response
0.50	GO:0070932	histone H3 deacetylation
0.50	GO:0000122	negative regulation of transcription by RNA polymerase II
0.49	GO:0000724	double-strand break repair via homologous recombination
0.48	GO:0045944	positive regulation of transcription by RNA polymerase II
0.46	GO:0048681	negative regulation of axon regeneration

0.58	GO:0003723	RNA binding
0.52	GO:0042826	histone deacetylase binding
0.51	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.50	GO:0001047	core promoter binding
0.48	GO:0042803	protein homodimerization activity
0.48	GO:0003682	chromatin binding

0.55	GO:0042382	paraspeckles
0.52	GO:0016363	nuclear matrix
0.48	GO:0090575	RNA polymerase II transcription factor complex
0.47	GO:0000785	chromatin
0.37	GO:0031012	extracellular matrix
0.36	GO:0016607	nuclear speck
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|P23258|TBG1_HUMAN
Tubulin gamma-1 chain
Search

TUBG1

0.71	Tubulin gamma chain

0.84	GO:0031122	cytoplasmic microtubule organization
0.81	GO:0007020	microtubule nucleation
0.47	GO:0000212	meiotic spindle organization
0.35	GO:0007346	regulation of mitotic cell cycle
0.35	GO:1903047	mitotic cell cycle process
0.35	GO:0097711	ciliary basal body-plasma membrane docking
0.35	GO:0010564	regulation of cell cycle process
0.35	GO:0044839	cell cycle G2/M phase transition
0.34	GO:0051783	regulation of nuclear division

0.68	GO:0003924	GTPase activity
0.65	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0042802	identical protein binding
0.35	GO:0005200	structural constituent of cytoskeleton

0.84	GO:0000930	gamma-tubulin complex
0.73	GO:0005874	microtubule
0.54	GO:0000242	pericentriolar material
0.51	GO:0005819	spindle
0.47	GO:0055037	recycling endosome
0.46	GO:0036064	ciliary basal body
0.46	GO:0097730	non-motile cilium
0.46	GO:0005814	centriole
0.45	GO:0045177	apical part of cell
0.45	GO:0031252	cell leading edge

sp|P23276|KELL_HUMAN
Kell blood group glycoprotein
Search

KEL

0.97	Truncated kell blood group antigen Cellano

0.67	GO:0031133	regulation of axon diameter
0.65	GO:0010961	cellular magnesium ion homeostasis
0.65	GO:1901380	negative regulation of potassium ion transmembrane transport
0.63	GO:0048741	skeletal muscle fiber development
0.62	GO:0042552	myelination
0.60	GO:0008361	regulation of cell size
0.60	GO:0006508	proteolysis
0.59	GO:0006874	cellular calcium ion homeostasis
0.38	GO:0042310	vasoconstriction

0.70	GO:0004222	metalloendopeptidase activity
0.35	GO:0005515	protein binding
0.34	GO:0046872	metal ion binding

0.35	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.70

GO:0004222

sp|P23280|CAH6_HUMAN
Carbonic anhydrase 6
Search

CA6

0.89	Stress-inducible intra-cellular carbonic anhydrase isozyme VI

0.71	GO:0006730	one-carbon metabolic process
0.59	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
0.38	GO:0015701	bicarbonate transport
0.32	GO:0006414	translational elongation

0.77	GO:0004089	carbonate dehydratase activity
0.62	GO:0008270	zinc ion binding
0.33	GO:0005515	protein binding
0.32	GO:0003746	translation elongation factor activity

0.51	GO:0005615	extracellular space
0.42	GO:0005829	cytosol
0.38	GO:1903561	extracellular vesicle
0.34	GO:0009570	chloroplast stroma
0.30	GO:0016021	integral component of membrane

0.77

GO:0004089

sp|P23284|PPIB_HUMAN
Peptidyl-prolyl cis-trans isomerase B
Search

PPIB

0.48	Peptidyl-prolyl cis-trans isomerase B

0.72	GO:0000413	protein peptidyl-prolyl isomerization
0.68	GO:0006457	protein folding
0.57	GO:0044829	positive regulation by host of viral genome replication
0.54	GO:0040018	positive regulation of multicellular organism growth
0.53	GO:0060348	bone development
0.52	GO:0050821	protein stabilization
0.37	GO:1901873	regulation of post-translational protein modification
0.34	GO:0051169	nuclear transport

0.72	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.50	GO:0070063	RNA polymerase binding
0.49	GO:0032403	protein complex binding
0.34	GO:0051082	unfolded protein binding
0.34	GO:0003723	RNA binding
0.32	GO:0046872	metal ion binding

0.55	GO:0034663	endoplasmic reticulum chaperone complex
0.51	GO:0048471	perinuclear region of cytoplasm
0.44	GO:0005634	nucleus
0.40	GO:0005788	endoplasmic reticulum lumen
0.40	GO:0042470	melanosome
0.40	GO:0005790	smooth endoplasmic reticulum
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.72

GO:0003755

sp|P23297|S10A1_HUMAN
Protein S100-A1
Search

sp|P23327|SRCH_HUMAN
Sarcoplasmic reticulum histidine-rich calcium-binding protein
Search

HRC

0.94	Sarcoplasmic reticulum histidine-rich calcium-binding protein

0.70	GO:1901899	positive regulation of relaxation of cardiac muscle
0.68	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction
0.67	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
0.67	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
0.66	GO:0045823	positive regulation of heart contraction
0.64	GO:0002027	regulation of heart rate
0.62	GO:0033135	regulation of peptidyl-serine phosphorylation
0.62	GO:0055074	calcium ion homeostasis
0.61	GO:0072503	cellular divalent inorganic cation homeostasis
0.57	GO:0006875	cellular metal ion homeostasis

0.69	GO:0005509	calcium ion binding
0.64	GO:0044325	ion channel binding
0.63	GO:0051117	ATPase binding
0.33	GO:0030331	estrogen receptor binding
0.33	GO:0016851	magnesium chelatase activity
0.33	GO:0051082	unfolded protein binding
0.33	GO:0003712	transcription cofactor activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0003682	chromatin binding
0.33	GO:0032553	ribonucleotide binding

0.63	GO:0030018	Z disc
0.59	GO:0016529	sarcoplasmic reticulum
0.48	GO:0044432	endoplasmic reticulum part
0.47	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.46	GO:0098588	bounding membrane of organelle
0.45	GO:0031984	organelle subcompartment
0.39	GO:0032040	small-subunit processome
0.36	GO:0070013	intracellular organelle lumen
0.33	GO:0005634	nucleus
0.33	GO:0030688	preribosome, small subunit precursor

0.33	EC:6.6.1.1	GO:0016851
0.33	KEGG:R03877	GO:0016851

sp|P23352|KALM_HUMAN
Anosmin-1
Search

ANOS1

0.95	Kallmann syndrome 1

0.74	GO:0010466	negative regulation of peptidase activity
0.43	GO:0097155	fasciculation of sensory neuron axon
0.43	GO:0048920	posterior lateral line neuromast primordium migration
0.43	GO:0097154	GABAergic neuron differentiation
0.42	GO:0071542	dopaminergic neuron differentiation
0.42	GO:0021772	olfactory bulb development
0.42	GO:0007411	axon guidance
0.37	GO:0052548	regulation of endopeptidase activity
0.37	GO:0007155	cell adhesion
0.36	GO:0008543	fibroblast growth factor receptor signaling pathway

0.74	GO:0030414	peptidase inhibitor activity
0.37	GO:0061135	endopeptidase regulator activity
0.35	GO:0008201	heparin binding
0.35	GO:0005201	extracellular matrix structural constituent
0.34	GO:0005515	protein binding
0.32	GO:0016787	hydrolase activity

0.65	GO:0005576	extracellular region
0.36	GO:0009986	cell surface
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016787

sp|P23368|MAOM_HUMAN
NAD-dependent malic enzyme, mitochondrial
Search

ME2

0.57	NAD-dependent malic enzyme, mitochondrial

0.57	GO:1902031	regulation of NADP metabolic process
0.52	GO:0055114	oxidation-reduction process
0.46	GO:0006108	malate metabolic process
0.43	GO:0006090	pyruvate metabolic process
0.34	GO:0042779	tRNA 3'-trailer cleavage
0.34	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.33	GO:0006468	protein phosphorylation
0.33	GO:0006091	generation of precursor metabolites and energy

0.78	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity
0.67	GO:0051287	NAD binding
0.53	GO:0046872	metal ion binding
0.48	GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity
0.36	GO:0008948	oxaloacetate decarboxylase activity
0.34	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters
0.33	GO:0009055	electron transfer activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032553	ribonucleotide binding

0.45	GO:0005739	mitochondrion
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.78	EC:1.1.1.38 EC:1.1.1.39	GO:0004471
0.78	KEGG:R00214	GO:0004471

sp|P23378|GCSP_HUMAN
Glycine dehydrogenase (decarboxylating), mitochondrial
Search

GLDC

0.71	Glycine dehydrogenase (decarboxylating), mitochondrial

0.75	GO:0006546	glycine catabolic process
0.52	GO:0055114	oxidation-reduction process
0.50	GO:1990830	cellular response to leukemia inhibitory factor
0.41	GO:0036255	response to methylamine
0.41	GO:1903442	response to lipoic acid
0.33	GO:0006091	generation of precursor metabolites and energy

0.78	GO:0016642	oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
0.57	GO:0016829	lyase activity
0.41	GO:0070280	pyridoxal binding
0.39	GO:0016594	glycine binding
0.37	GO:0042803	protein homodimerization activity
0.37	GO:0019899	enzyme binding
0.36	GO:0047960	glycine dehydrogenase activity
0.36	GO:0030170	pyridoxal phosphate binding
0.33	GO:0009055	electron transfer activity

0.59	GO:0005739	mitochondrion
0.45	GO:0005634	nucleus
0.42	GO:0005886	plasma membrane
0.38	GO:0005960	glycine cleavage complex
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part

0.78

EC:1.4.4

GO:0016642

sp|P23381|SYWC_HUMAN
Tryptophan--tRNA ligase, cytoplasmic
Search

WARS

0.57	Tryptophanyl-tRNA synthetase

0.78	GO:0006436	tryptophanyl-tRNA aminoacylation
0.58	GO:0010835	regulation of protein ADP-ribosylation
0.54	GO:0045765	regulation of angiogenesis
0.53	GO:0006469	negative regulation of protein kinase activity
0.52	GO:0031334	positive regulation of protein complex assembly
0.49	GO:0010628	positive regulation of gene expression
0.40	GO:0001525	angiogenesis
0.34	GO:0008285	negative regulation of cell proliferation

0.78	GO:0004830	tryptophan-tRNA ligase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0019210	kinase inhibitor activity
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0019901	protein kinase binding
0.51	GO:0019904	protein domain specific binding
0.51	GO:0042803	protein homodimerization activity

0.49	GO:0005829	cytosol
0.45	GO:0005634	nucleus
0.44	GO:0043234	protein complex
0.36	GO:0070062	extracellular exosome

0.78

EC:6.1.1.2

GO:0004830

sp|P23396|RS3_HUMAN
40S ribosomal protein S3
Search

RPS3

0.58	Ribosomal protein S3

0.59	GO:0006518	peptide metabolic process
0.59	GO:0043604	amide biosynthetic process
0.55	GO:0044267	cellular protein metabolic process
0.54	GO:0061481	response to TNF agonist
0.53	GO:1901566	organonitrogen compound biosynthetic process
0.53	GO:0010467	gene expression
0.53	GO:1905051	regulation of base-excision repair
0.53	GO:1902546	positive regulation of DNA N-glycosylase activity
0.53	GO:2001272	positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
0.52	GO:0009059	macromolecule biosynthetic process

0.63	GO:0003735	structural constituent of ribosome
0.58	GO:0003723	RNA binding
0.54	GO:0032358	oxidized pyrimidine DNA binding
0.52	GO:0032357	oxidized purine DNA binding
0.52	GO:0097100	supercoiled DNA binding
0.51	GO:0051879	Hsp90 protein binding
0.50	GO:0030544	Hsp70 protein binding
0.50	GO:0044390	ubiquitin-like protein conjugating enzyme binding
0.49	GO:0051018	protein kinase A binding
0.49	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity

0.69	GO:0015935	small ribosomal subunit
0.51	GO:0071159	NF-kappaB complex
0.50	GO:0032587	ruffle membrane
0.49	GO:0005844	polysome
0.49	GO:0022626	cytosolic ribosome
0.49	GO:0005819	spindle
0.47	GO:0005730	nucleolus
0.46	GO:0005759	mitochondrial matrix
0.44	GO:0005783	endoplasmic reticulum
0.43	GO:0031966	mitochondrial membrane

0.49

EC:4.2.99.18

GO:0003906

sp|P23409|MYF6_HUMAN
Myogenic factor 6
Search

MYF6

0.86	Myogenic regulatory factor 4

0.81	GO:0007517	muscle organ development
0.61	GO:0014706	striated muscle tissue development
0.58	GO:0001756	somitogenesis
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0006366	transcription by RNA polymerase II
0.55	GO:0048729	tissue morphogenesis
0.54	GO:1902680	positive regulation of RNA biosynthetic process
0.54	GO:0048743	positive regulation of skeletal muscle fiber development

0.68	GO:0046983	protein dimerization activity
0.59	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.55	GO:0003677	DNA binding
0.50	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.48	GO:0001067	regulatory region nucleic acid binding
0.40	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.39	GO:0003682	chromatin binding
0.33	GO:0004725	protein tyrosine phosphatase activity

0.61	GO:0005634	nucleus
0.38	GO:0070013	intracellular organelle lumen
0.36	GO:0044446	intracellular organelle part
0.36	GO:0005667	transcription factor complex
0.34	GO:0032993	protein-DNA complex
0.30	GO:0016020	membrane

0.33

GO:0004725

sp|P23415|GLRA1_HUMAN
Glycine receptor subunit alpha-1
Search

GLRA1

0.96	Glycine receptor subunit alpha-1

0.71	GO:0060079	excitatory postsynaptic potential
0.69	GO:1902476	chloride transmembrane transport
0.59	GO:0060012	synaptic transmission, glycinergic
0.59	GO:0051970	negative regulation of transmission of nerve impulse
0.58	GO:0071294	cellular response to zinc ion
0.58	GO:0071361	cellular response to ethanol
0.57	GO:2000344	positive regulation of acrosome reaction
0.57	GO:0060080	inhibitory postsynaptic potential
0.57	GO:0060013	righting reflex
0.57	GO:0002087	regulation of respiratory gaseous exchange by neurological system process

0.85	GO:0016594	glycine binding
0.79	GO:0016934	extracellularly glycine-gated chloride channel activity
0.76	GO:0022824	transmitter-gated ion channel activity
0.69	GO:0004888	transmembrane signaling receptor activity
0.60	GO:0043210	alkanesulfonate binding
0.45	GO:0008270	zinc ion binding
0.36	GO:0042802	identical protein binding

0.70	GO:0045211	postsynaptic membrane
0.66	GO:0005887	integral component of plasma membrane
0.56	GO:0060077	inhibitory synapse
0.54	GO:0043025	neuronal cell body
0.53	GO:0009897	external side of plasma membrane
0.52	GO:0043005	neuron projection
0.43	GO:0034707	chloride channel complex
0.42	GO:0043231	intracellular membrane-bounded organelle
0.40	GO:0120038	plasma membrane bounded cell projection part
0.39	GO:0030054	cell junction

sp|P23416|GLRA2_HUMAN
Glycine receptor subunit alpha-2
Search

GLRA2

0.90	Glycine receptor subunit alpha-2

0.69	GO:0060079	excitatory postsynaptic potential
0.66	GO:1902476	chloride transmembrane transport
0.60	GO:0043200	response to amino acid
0.58	GO:0071294	cellular response to zinc ion
0.57	GO:0071361	cellular response to ethanol
0.56	GO:0007218	neuropeptide signaling pathway
0.53	GO:0071229	cellular response to acid chemical
0.53	GO:0071417	cellular response to organonitrogen compound
0.51	GO:0060012	synaptic transmission, glycinergic
0.35	GO:0007416	synapse assembly

0.85	GO:0016594	glycine binding
0.76	GO:0022824	transmitter-gated ion channel activity
0.76	GO:0016934	extracellularly glycine-gated chloride channel activity
0.70	GO:0099600	transmembrane receptor activity
0.34	GO:0046872	metal ion binding

0.67	GO:0098794	postsynapse
0.66	GO:0005887	integral component of plasma membrane
0.66	GO:0097060	synaptic membrane
0.39	GO:0034707	chloride channel complex
0.37	GO:0030054	cell junction
0.36	GO:0042995	cell projection
0.35	GO:0043204	perikaryon

sp|P23434|GCSH_HUMAN
Glycine cleavage system H protein, mitochondrial
Search

GCSH

0.46	Glycine cleavage system H protein, mitochondrial

0.76	GO:0019464	glycine decarboxylation via glycine cleavage system
0.42	GO:0009249	protein lipoylation
0.34	GO:0032259	methylation
0.33	GO:0098869	cellular oxidant detoxification
0.32	GO:0055114	oxidation-reduction process
0.32	GO:0034641	cellular nitrogen compound metabolic process

0.36	GO:0004047	aminomethyltransferase activity
0.35	GO:0005515	protein binding
0.34	GO:0030246	carbohydrate binding
0.34	GO:0005509	calcium ion binding
0.33	GO:0004096	catalase activity
0.33	GO:0020037	heme binding

0.78	GO:0005960	glycine cleavage complex
0.59	GO:0005739	mitochondrion
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.36

EC:2.1.2.10

GO:0004047

sp|P23435|CBLN1_HUMAN
Cerebellin-1
Search

CBLN1

0.93	Cerebellin 1 precursor

0.80	GO:0051965	positive regulation of synapse assembly
0.77	GO:1900454	positive regulation of long term synaptic depression
0.76	GO:0090394	negative regulation of excitatory postsynaptic potential
0.74	GO:0021684	cerebellar granular layer formation
0.72	GO:0021533	cell differentiation in hindbrain
0.70	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
0.68	GO:0021953	central nervous system neuron differentiation
0.59	GO:0009306	protein secretion
0.37	GO:0048168	regulation of neuronal synaptic plasticity
0.37	GO:0007268	chemical synaptic transmission

0.62	GO:0042803	protein homodimerization activity
0.35	GO:0003676	nucleic acid binding
0.34	GO:0046872	metal ion binding

0.62	GO:0045202	synapse
0.54	GO:0005615	extracellular space
0.43	GO:0098590	plasma membrane region
0.42	GO:0030054	cell junction
0.30	GO:0016021	integral component of membrane

sp|P23443|KS6B1_HUMAN
Ribosomal protein S6 kinase beta-1
Search

RPS6KB1

0.75	Ribosomal protein S6 kinase beta-1

0.63	GO:0006468	protein phosphorylation
0.59	GO:0007165	signal transduction
0.58	GO:0071549	cellular response to dexamethasone stimulus
0.58	GO:0046627	negative regulation of insulin receptor signaling pathway
0.57	GO:0001662	behavioral fear response
0.57	GO:0045948	positive regulation of translational initiation
0.56	GO:0032869	cellular response to insulin stimulus
0.56	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
0.55	GO:0000082	G1/S transition of mitotic cell cycle
0.55	GO:0045931	positive regulation of mitotic cell cycle

0.69	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0004712	protein serine/threonine/tyrosine kinase activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0008144	drug binding
0.51	GO:0004435	phosphatidylinositol phospholipase C activity
0.38	GO:0051721	protein phosphatase 2A binding
0.38	GO:0030165	PDZ domain binding
0.37	GO:0042277	peptide binding

0.49	GO:0005654	nucleoplasm
0.45	GO:0005739	mitochondrion
0.39	GO:0043005	neuron projection
0.39	GO:0031968	organelle outer membrane
0.39	GO:0045202	synapse
0.38	GO:0030054	cell junction
0.37	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0009986	cell surface
0.36	GO:0005829	cytosol
0.35	GO:0005840	ribosome

0.69	EC:2.7.11	GO:0004674
0.51	KEGG:R03435	GO:0004435

sp|P23458|JAK1_HUMAN
Tyrosine-protein kinase JAK1
Search

JAK1

0.60	Tyrosine-protein kinase

0.75	GO:0018108	peptidyl-tyrosine phosphorylation
0.61	GO:0035556	intracellular signal transduction
0.59	GO:0038110	interleukin-2-mediated signaling pathway
0.58	GO:1903672	positive regulation of sprouting angiogenesis
0.51	GO:0046677	response to antibiotic
0.45	GO:0046777	protein autophosphorylation
0.44	GO:0045087	innate immune response
0.44	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.43	GO:0016477	cell migration
0.43	GO:0042127	regulation of cell proliferation

0.79	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.56	GO:0019903	protein phosphatase binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0031625	ubiquitin protein ligase binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0005102	receptor binding

0.67	GO:0005856	cytoskeleton
0.45	GO:0005634	nucleus
0.44	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.39	GO:0005737	cytoplasm
0.35	GO:0005925	focal adhesion

0.79

GO:0004715

sp|P23467|PTPRB_HUMAN
Receptor-type tyrosine-protein phosphatase beta
Search

PTPRB

0.59	Receptor-type tyrosine-protein phosphatase beta

0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.53	GO:0001525	angiogenesis
0.36	GO:0043312	neutrophil degranulation

0.74	GO:0004725	protein tyrosine phosphatase activity
0.36	GO:0019198	transmembrane receptor protein phosphatase activity
0.33	GO:0005515	protein binding

0.53	GO:0043235	receptor complex
0.36	GO:0035579	specific granule membrane
0.36	GO:0070821	tertiary granule membrane
0.34	GO:0005887	integral component of plasma membrane

0.74

GO:0004725

sp|P23468|PTPRD_HUMAN
Receptor-type tyrosine-protein phosphatase delta
Search

PTPRD

0.89	Protein tyrosine phosphatase receptor type D

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.39	GO:0097105	presynaptic membrane assembly
0.38	GO:0050775	positive regulation of dendrite morphogenesis
0.38	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
0.38	GO:0046426	negative regulation of JAK-STAT cascade
0.38	GO:0051965	positive regulation of synapse assembly
0.37	GO:0030182	neuron differentiation
0.36	GO:0050776	regulation of immune response

0.75	GO:0004725	protein tyrosine phosphatase activity
0.37	GO:0050839	cell adhesion molecule binding
0.36	GO:0005102	receptor binding

0.37	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.75

GO:0004725

sp|P23469|PTPRE_HUMAN
Receptor-type tyrosine-protein phosphatase epsilon
Search

PTPRE

0.82	Receptor-type tyrosine-protein phosphatase epsilon

0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.47	GO:0046627	negative regulation of insulin receptor signaling pathway
0.47	GO:0060027	convergent extension involved in gastrulation
0.44	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway
0.42	GO:0033003	regulation of mast cell activation

0.75	GO:0004725	protein tyrosine phosphatase activity
0.40	GO:0042803	protein homodimerization activity
0.40	GO:0019198	transmembrane receptor protein phosphatase activity

0.48	GO:0005634	nucleus
0.45	GO:0005886	plasma membrane
0.41	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.75

GO:0004725

sp|P23470|PTPRG_HUMAN
Receptor-type tyrosine-protein phosphatase gamma
Search

PTPRG

0.92	Protein tyrosine phosphatase, receptor type G

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.73	GO:0010633	negative regulation of epithelial cell migration
0.43	GO:1903385	regulation of homophilic cell adhesion
0.41	GO:0010977	negative regulation of neuron projection development
0.40	GO:1901998	toxin transport
0.40	GO:0007420	brain development

0.75	GO:0004725	protein tyrosine phosphatase activity
0.63	GO:0042802	identical protein binding

0.40	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.75

GO:0004725

sp|P23471|PTPRZ_HUMAN
Receptor-type tyrosine-protein phosphatase zeta
Search

PTPRZ1

0.44	Receptor-type tyrosine-protein phosphatase zeta

0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.62	GO:0070445	regulation of oligodendrocyte progenitor proliferation
0.59	GO:0048709	oligodendrocyte differentiation
0.59	GO:0002244	hematopoietic progenitor cell differentiation
0.57	GO:0007611	learning or memory
0.56	GO:0007409	axonogenesis
0.37	GO:1900149	positive regulation of Schwann cell migration
0.36	GO:2001224	positive regulation of neuron migration
0.36	GO:2000171	negative regulation of dendrite development
0.36	GO:0007413	axonal fasciculation

0.74	GO:0004725	protein tyrosine phosphatase activity
0.37	GO:0019198	transmembrane receptor protein phosphatase activity
0.37	GO:0005515	protein binding

0.63	GO:0072534	perineuronal net
0.54	GO:0005578	proteinaceous extracellular matrix
0.37	GO:0031226	intrinsic component of plasma membrane
0.36	GO:0032587	ruffle membrane
0.36	GO:0043197	dendritic spine
0.36	GO:0030175	filopodium
0.36	GO:0030426	growth cone
0.36	GO:0030027	lamellipodium
0.36	GO:0043025	neuronal cell body
0.35	GO:0030424	axon

0.74

GO:0004725

sp|P23490|LORI_HUMAN
Loricrin
Search

LOR

0.74

Loricrin

0.55	GO:0030216	keratinocyte differentiation
0.46	GO:0018149	peptide cross-linking
0.43	GO:0007010	cytoskeleton organization
0.42	GO:0012501	programmed cell death
0.38	GO:0006413	translational initiation
0.38	GO:0010501	RNA secondary structure unwinding
0.36	GO:0007059	chromosome segregation
0.36	GO:0051641	cellular localization
0.36	GO:0048193	Golgi vesicle transport
0.35	GO:0070647	protein modification by small protein conjugation or removal

0.83	GO:0030280	structural constituent of epidermis
0.44	GO:0005200	structural constituent of cytoskeleton
0.43	GO:0030674	protein binding, bridging
0.39	GO:0003723	RNA binding
0.37	GO:0004004	ATP-dependent RNA helicase activity
0.35	GO:0003697	single-stranded DNA binding
0.35	GO:0051020	GTPase binding
0.35	GO:0008270	zinc ion binding
0.35	GO:0098772	molecular function regulator
0.34	GO:0032559	adenyl ribonucleotide binding

0.79	GO:0001533	cornified envelope
0.41	GO:0031981	nuclear lumen
0.40	GO:0005829	cytosol
0.39	GO:0005882	intermediate filament
0.38	GO:0009898	cytoplasmic side of plasma membrane
0.37	GO:0036464	cytoplasmic ribonucleoprotein granule
0.34	GO:0005776	autophagosome
0.34	GO:0005813	centrosome
0.34	GO:0055037	recycling endosome
0.30	GO:0031224	intrinsic component of membrane

0.34	EC:3.4.19.12	GO:0036459
0.34	KEGG:R03876	GO:0004842

sp|P23497|SP100_HUMAN
Nuclear autoantigen Sp-100
Search

SP100

0.93	SP100 nuclear antigen

0.69	GO:1902044	regulation of Fas signaling pathway
0.67	GO:0046826	negative regulation of protein export from nucleus
0.66	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
0.65	GO:0034340	response to type I interferon
0.64	GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors
0.64	GO:0010596	negative regulation of endothelial cell migration
0.63	GO:0043392	negative regulation of DNA binding
0.63	GO:0034341	response to interferon-gamma
0.62	GO:0043433	negative regulation of DNA binding transcription factor activity
0.61	GO:0045765	regulation of angiogenesis

0.67	GO:0070087	chromo shadow domain binding
0.60	GO:0003714	transcription corepressor activity
0.59	GO:0003713	transcription coactivator activity
0.59	GO:0019900	kinase binding
0.57	GO:0042803	protein homodimerization activity
0.52	GO:0003677	DNA binding
0.48	GO:0046872	metal ion binding

0.63	GO:0016605	PML body
0.62	GO:0030870	Mre11 complex
0.41	GO:0005737	cytoplasm

sp|P23508|CRCM_HUMAN
Colorectal mutant cancer protein
Search

MCC

0.95	Mutated in colorectal cancers

0.70	GO:0010633	negative regulation of epithelial cell migration
0.69	GO:0050680	negative regulation of epithelial cell proliferation
0.69	GO:0090090	negative regulation of canonical Wnt signaling pathway
0.55	GO:0045184	establishment of protein localization
0.42	GO:0060027	convergent extension involved in gastrulation
0.38	GO:0016055	Wnt signaling pathway

0.63	GO:0005509	calcium ion binding
0.39	GO:0005515	protein binding
0.36	GO:0004872	receptor activity

0.57	GO:0005654	nucleoplasm
0.56	GO:0005829	cytosol
0.48	GO:0005886	plasma membrane
0.39	GO:0030027	lamellipodium

sp|P23510|TNFL4_HUMAN
Tumor necrosis factor ligand superfamily member 4
Search

TNFSF4

0.97	Tumor necrosis factor ligand superfamily member 4

0.74	GO:0006955	immune response
0.70	GO:0032753	positive regulation of interleukin-4 production
0.70	GO:0032700	negative regulation of interleukin-17 production
0.70	GO:0071380	cellular response to prostaglandin E stimulus
0.68	GO:0032729	positive regulation of interferon-gamma production
0.68	GO:0032755	positive regulation of interleukin-6 production
0.66	GO:0050729	positive regulation of inflammatory response
0.65	GO:0071222	cellular response to lipopolysaccharide
0.61	GO:0010469	regulation of receptor activity
0.54	GO:0042102	positive regulation of T cell proliferation

0.83	GO:0005164	tumor necrosis factor receptor binding
0.65	GO:0005125	cytokine activity
0.35	GO:0015299	solute:proton antiporter activity

0.66	GO:0005615	extracellular space
0.60	GO:0009986	cell surface
0.36	GO:0005887	integral component of plasma membrane

sp|P23511|NFYA_HUMAN
Nuclear transcription factor Y subunit alpha
Search

NFYA

0.93	Nuclear transcription factor Y subunit alpha

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.38	GO:0048511	rhythmic process
0.37	GO:1902680	positive regulation of RNA biosynthetic process
0.37	GO:2000036	regulation of stem cell population maintenance
0.37	GO:2000648	positive regulation of stem cell proliferation
0.37	GO:0006366	transcription by RNA polymerase II
0.35	GO:0045540	regulation of cholesterol biosynthetic process

0.60	GO:0003700	DNA binding transcription factor activity
0.54	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.39	GO:0001046	core promoter sequence-specific DNA binding
0.36	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0001221	transcription cofactor binding

0.81	GO:0016602	CCAAT-binding factor complex
0.48	GO:0032993	protein-DNA complex
0.47	GO:0005654	nucleoplasm

sp|P23515|OMGP_HUMAN
Oligodendrocyte-myelin glycoprotein
Search

OMG

0.97	Oligodendrocyte myelin glycoprotein variant (Fragment)

0.75	GO:0031175	neuron projection development
0.73	GO:0048667	cell morphogenesis involved in neuron differentiation
0.72	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.59	GO:0048683	regulation of collateral sprouting of intact axon in response to injury
0.53	GO:0031099	regeneration
0.45	GO:0007155	cell adhesion
0.45	GO:0050771	negative regulation of axonogenesis
0.45	GO:0022010	central nervous system myelination
0.45	GO:0033554	cellular response to stress
0.41	GO:0009190	cyclic nucleotide biosynthetic process

0.49	GO:0042802	identical protein binding
0.41	GO:0016849	phosphorus-oxygen lyase activity
0.40	GO:0009975	cyclase activity
0.40	GO:0046983	protein dimerization activity
0.38	GO:0000287	magnesium ion binding
0.37	GO:0004672	protein kinase activity
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding

0.71	GO:0005578	proteinaceous extracellular matrix
0.69	GO:0005615	extracellular space
0.48	GO:0031225	anchored component of membrane
0.43	GO:0043209	myelin sheath
0.39	GO:0005886	plasma membrane
0.34	GO:0005622	intracellular
0.33	GO:0031301	integral component of organelle membrane
0.33	GO:0012505	endomembrane system
0.32	GO:0031975	envelope

0.41

EC:4.6

GO:0016849

sp|P23526|SAHH_HUMAN
Adenosylhomocysteinase
Search

AHCY

0.56	Adenosylhomocysteinase A

0.77	GO:0019510	S-adenosylhomocysteine catabolic process
0.72	GO:0006730	one-carbon metabolic process
0.48	GO:0033353	S-adenosylmethionine cycle
0.38	GO:0002439	chronic inflammatory response to antigenic stimulus
0.37	GO:0042745	circadian sleep/wake cycle
0.36	GO:0071268	homocysteine biosynthetic process
0.36	GO:0001666	response to hypoxia
0.36	GO:0007584	response to nutrient
0.33	GO:0032259	methylation

0.80	GO:0004013	adenosylhomocysteinase activity
0.65	GO:0051287	NAD binding
0.38	GO:0043621	protein self-association
0.36	GO:0098604	adenosylselenohomocysteinase activity
0.36	GO:0005507	copper ion binding
0.35	GO:0042802	identical protein binding
0.33	GO:0030554	adenyl nucleotide binding

0.47	GO:0005829	cytosol
0.41	GO:0042470	melanosome
0.36	GO:0070062	extracellular exosome
0.36	GO:0043005	neuron projection
0.34	GO:0005634	nucleus

0.80

EC:3.3.1.1

GO:0004013

sp|P23527|H2B1O_HUMAN
Histone H2B type 1-O
Search

sp|P23528|COF1_HUMAN
Cofilin-1
Search

CFL1

0.93	Cofilin 1, non-muscle

0.84	GO:0030042	actin filament depolymerization
0.59	GO:0030836	positive regulation of actin filament depolymerization
0.54	GO:0046716	muscle cell cellular homeostasis
0.53	GO:0009888	tissue development
0.53	GO:0045214	sarcomere organization
0.52	GO:0048513	animal organ development
0.48	GO:0044794	positive regulation by host of viral process
0.47	GO:0061001	regulation of dendritic spine morphogenesis
0.47	GO:0048864	stem cell development
0.47	GO:0043200	response to amino acid

0.74	GO:0003779	actin binding
0.55	GO:0032403	protein complex binding
0.43	GO:0005102	receptor binding
0.37	GO:0019903	protein phosphatase binding
0.37	GO:1902936	phosphatidylinositol bisphosphate binding
0.34	GO:0046872	metal ion binding

0.74	GO:0015629	actin cytoskeleton
0.52	GO:0030018	Z disc
0.48	GO:0030027	lamellipodium
0.46	GO:0030863	cortical cytoskeleton
0.44	GO:0005911	cell-cell junction
0.44	GO:0016363	nuclear matrix
0.44	GO:0005615	extracellular space
0.42	GO:0044430	cytoskeletal part
0.42	GO:0032587	ruffle membrane
0.38	GO:1903561	extracellular vesicle

sp|P23560|BDNF_HUMAN
Brain-derived neurotrophic factor
Search

BDNF

0.59	Brain-derived neurotrophic factor

0.75	GO:0010469	regulation of receptor activity
0.51	GO:1900122	positive regulation of receptor binding
0.51	GO:0048672	positive regulation of collateral sprouting
0.51	GO:0048668	collateral sprouting
0.49	GO:0051965	positive regulation of synapse assembly
0.49	GO:0007416	synapse assembly
0.42	GO:0043524	negative regulation of neuron apoptotic process
0.41	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.40	GO:0007267	cell-cell signaling
0.37	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway

0.78	GO:0008083	growth factor activity
0.44	GO:0005169	neurotrophin TRKB receptor binding

0.66	GO:0005576	extracellular region
0.47	GO:0016607	nuclear speck
0.41	GO:0005739	mitochondrion
0.40	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0031410	cytoplasmic vesicle
0.36	GO:0030425	dendrite
0.36	GO:0030424	axon
0.36	GO:0098794	postsynapse
0.35	GO:0043204	perikaryon
0.35	GO:0043679	axon terminus

sp|P23582|ANFC_HUMAN
C-type natriuretic peptide
Search

NPPC

0.96	C-type natriuretic peptide

0.79	GO:0050880	regulation of blood vessel size
0.75	GO:0010469	regulation of receptor activity
0.67	GO:0003419	growth plate cartilage chondrocyte proliferation
0.66	GO:1900194	negative regulation of oocyte maturation
0.66	GO:0003418	growth plate cartilage chondrocyte differentiation
0.66	GO:0007168	receptor guanylyl cyclase signaling pathway
0.63	GO:0030823	regulation of cGMP metabolic process
0.62	GO:0051447	negative regulation of meiotic cell cycle
0.62	GO:0030814	regulation of cAMP metabolic process
0.61	GO:0006182	cGMP biosynthetic process

0.79	GO:0005179	hormone activity
0.61	GO:0051427	hormone receptor binding
0.41	GO:0090729	toxin activity
0.40	GO:0042803	protein homodimerization activity
0.39	GO:0008191	metalloendopeptidase inhibitor activity
0.35	GO:0005272	sodium channel activity
0.35	GO:0005267	potassium channel activity
0.34	GO:0060422	peptidyl-dipeptidase inhibitor activity

0.66	GO:0005576	extracellular region
0.47	GO:0043234	protein complex
0.42	GO:0030141	secretory granule
0.33	GO:0005829	cytosol
0.32	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P23588|IF4B_HUMAN
Eukaryotic translation initiation factor 4B
Search

EIF4B

0.87	LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4B

0.85	GO:0097010	eukaryotic translation initiation factor 4F complex assembly
0.70	GO:0006413	translational initiation
0.45	GO:0002181	cytoplasmic translation
0.44	GO:0022618	ribonucleoprotein complex assembly
0.36	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
0.35	GO:0006446	regulation of translational initiation

0.64	GO:0003743	translation initiation factor activity
0.48	GO:0043024	ribosomal small subunit binding
0.48	GO:0034057	RNA strand-exchange activity
0.47	GO:0033592	RNA strand annealing activity
0.34	GO:0004386	helicase activity
0.34	GO:0005515	protein binding
0.33	GO:0005198	structural molecule activity

0.49	GO:0016281	eukaryotic translation initiation factor 4F complex
0.46	GO:0005844	polysome
0.46	GO:0005829	cytosol
0.38	GO:0043025	neuronal cell body
0.38	GO:0030425	dendrite
0.35	GO:0005882	intermediate filament

sp|P23610|F8I2_HUMAN
Factor VIII intron 22 protein
Search

F8A1

0.83	Coagulation factor VIII-associated 1

0.59	GO:0005634	nucleus
0.43	GO:0005737	cytoplasm

sp|P23634|AT2B4_HUMAN
Plasma membrane calcium-transporting ATPase 4
Search

ATP2B4

0.60	Plasma membrane calcium-transporting ATPase 4

0.77	GO:0070588	calcium ion transmembrane transport
0.69	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.56	GO:0006874	cellular calcium ion homeostasis
0.53	GO:1901660	calcium ion export
0.52	GO:0098736	negative regulation of the force of heart contraction
0.52	GO:1903248	regulation of citrulline biosynthetic process
0.52	GO:2000283	negative regulation of cellular amino acid biosynthetic process
0.52	GO:1900082	negative regulation of arginine catabolic process
0.52	GO:1901205	negative regulation of adrenergic receptor signaling pathway involved in heart process
0.51	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress

0.81	GO:0005388	calcium-transporting ATPase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0036487	nitric-oxide synthase inhibitor activity
0.50	GO:0030346	protein phosphatase 2B binding
0.50	GO:0050998	nitric-oxide synthase binding
0.49	GO:0030165	PDZ domain binding
0.48	GO:0005516	calmodulin binding

0.49	GO:0030315	T-tubule
0.48	GO:0036126	sperm flagellum
0.48	GO:0030018	Z disc
0.43	GO:0005887	integral component of plasma membrane
0.42	GO:0005634	nucleus
0.40	GO:0016323	basolateral plasma membrane
0.40	GO:0032591	dendritic spine membrane
0.40	GO:0098857	membrane microdomain
0.39	GO:0032809	neuronal cell body membrane
0.38	GO:0016324	apical plasma membrane

0.81

EC:3.6.3.8

GO:0005388

sp|P23677|IP3KA_HUMAN
Inositol-trisphosphate 3-kinase A
Search

ITPKA

0.52	Inositol-trisphosphate 3-kinase A

0.86	GO:0097062	dendritic spine maintenance
0.86	GO:0061003	positive regulation of dendritic spine morphogenesis
0.83	GO:0032958	inositol phosphate biosynthetic process
0.81	GO:0048167	regulation of synaptic plasticity
0.76	GO:0006020	inositol metabolic process
0.71	GO:0030036	actin cytoskeleton organization
0.61	GO:0006468	protein phosphorylation
0.47	GO:0007165	signal transduction

0.86	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity
0.83	GO:0048365	Rac GTPase binding
0.80	GO:0004683	calmodulin-dependent protein kinase activity
0.76	GO:0005516	calmodulin binding
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding

0.82	GO:0043197	dendritic spine
0.52	GO:0005829	cytosol

0.86	EC:2.7.1.127	GO:0008440
0.86	KEGG:R03433	GO:0008440

sp|P23743|DGKA_HUMAN
Diacylglycerol kinase alpha
Search

DGKA

0.48	Diacylglycerol kinase alpha

0.82	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
0.62	GO:0035556	intracellular signal transduction
0.57	GO:0016310	phosphorylation
0.56	GO:0046339	diacylglycerol metabolic process
0.52	GO:0006654	phosphatidic acid biosynthetic process
0.50	GO:0030258	lipid modification
0.36	GO:0030168	platelet activation

0.80	GO:0004143	diacylglycerol kinase activity
0.75	GO:0003951	NAD+ kinase activity
0.69	GO:0005509	calcium ion binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0005543	phospholipid binding

0.47	GO:0005829	cytosol
0.42	GO:0005886	plasma membrane
0.33	GO:0005634	nucleus

0.80	EC:2.7.1.107	GO:0004143
0.75	KEGG:R00104	GO:0003951

sp|P23759|PAX7_HUMAN
Paired box protein Pax-7
Search

PAX7

0.92	Paired box protein 7 alpha variant 3

0.69	GO:0007275	multicellular organism development
0.57	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:0042060	wound healing
0.53	GO:2000288	positive regulation of myoblast proliferation
0.51	GO:0031062	positive regulation of histone methylation
0.51	GO:0045595	regulation of cell differentiation
0.50	GO:0031099	regeneration

0.64	GO:0043565	sequence-specific DNA binding
0.51	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding
0.33	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.34	GO:0005667	transcription factor complex

sp|P23760|PAX3_HUMAN
Paired box protein Pax-3
Search

PAX3

0.92	Paired box protein Pax-3-B

0.67	GO:0007275	multicellular organism development
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0006351	transcription, DNA-templated
0.55	GO:0010468	regulation of gene expression
0.50	GO:0051254	positive regulation of RNA metabolic process
0.50	GO:0010557	positive regulation of macromolecule biosynthetic process
0.50	GO:0031328	positive regulation of cellular biosynthetic process
0.45	GO:0048863	stem cell differentiation
0.45	GO:0009888	tissue development

0.63	GO:0043565	sequence-specific DNA binding
0.39	GO:0071837	HMG box domain binding
0.37	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.36	GO:0003682	chromatin binding
0.32	GO:0046872	metal ion binding

0.60	GO:0005634	nucleus
0.47	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.34	GO:0005667	transcription factor complex
0.30	GO:0031224	intrinsic component of membrane

sp|P23763|VAMP1_HUMAN
Vesicle-associated membrane protein 1
Search

VAMP1

0.77	Sodium channel epithelial 1 alpha subunit

0.69	GO:0016192	vesicle-mediated transport
0.55	GO:0090174	organelle membrane fusion
0.54	GO:0016050	vesicle organization
0.48	GO:0001921	positive regulation of receptor recycling
0.48	GO:0043623	cellular protein complex assembly
0.47	GO:0034446	substrate adhesion-dependent cell spreading
0.47	GO:0061951	establishment of protein localization to plasma membrane
0.47	GO:0071346	cellular response to interferon-gamma
0.46	GO:0032940	secretion by cell
0.46	GO:1903531	negative regulation of secretion by cell

0.48	GO:0000149	SNARE binding
0.47	GO:0005484	SNAP receptor activity
0.35	GO:0015280	ligand-gated sodium channel activity
0.35	GO:0050699	WW domain binding

0.52	GO:0030141	secretory granule
0.52	GO:0031201	SNARE complex
0.50	GO:0009986	cell surface
0.47	GO:0030659	cytoplasmic vesicle membrane
0.46	GO:0055037	recycling endosome
0.46	GO:0045335	phagocytic vesicle
0.45	GO:0098805	whole membrane
0.45	GO:0030136	clathrin-coated vesicle
0.45	GO:0098588	bounding membrane of organelle
0.45	GO:0048471	perinuclear region of cytoplasm

sp|P23769|GATA2_HUMAN
Endothelial transcription factor GATA-2
Search

GATA2

0.37	Endothelial transcription factor GATA-2

0.74	GO:0030097	hemopoiesis
0.60	GO:1903708	positive regulation of hemopoiesis
0.60	GO:0021514	ventral spinal cord interneuron differentiation
0.60	GO:1902105	regulation of leukocyte differentiation
0.59	GO:0070345	negative regulation of fat cell proliferation
0.59	GO:2000352	negative regulation of endothelial cell apoptotic process
0.59	GO:2000977	regulation of forebrain neuron differentiation
0.59	GO:0010725	regulation of primitive erythrocyte differentiation
0.58	GO:0045599	negative regulation of fat cell differentiation
0.58	GO:0045597	positive regulation of cell differentiation

0.64	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.58	GO:0044212	transcription regulatory region DNA binding
0.58	GO:0070742	C2H2 zinc finger domain binding
0.56	GO:0003690	double-stranded DNA binding
0.55	GO:0003682	chromatin binding
0.53	GO:0008134	transcription factor binding
0.41	GO:0071837	HMG box domain binding
0.40	GO:0005134	interleukin-2 receptor binding

0.59	GO:0005634	nucleus
0.48	GO:0070013	intracellular organelle lumen
0.47	GO:0005667	transcription factor complex
0.44	GO:0044446	intracellular organelle part
0.37	GO:0005694	chromosome

sp|P23771|GATA3_HUMAN
Trans-acting T-cell-specific transcription factor GATA-3
Search

GATA3

0.96	Trans-acting T-cell-specific transcription factor GATA-3

0.84	GO:0045582	positive regulation of T cell differentiation
0.61	GO:2000611	positive regulation of thyroid hormone generation
0.61	GO:2000667	positive regulation of interleukin-13 secretion
0.60	GO:2000683	regulation of cellular response to X-ray
0.60	GO:2000664	positive regulation of interleukin-5 secretion
0.60	GO:0033600	negative regulation of mammary gland epithelial cell proliferation
0.59	GO:0060231	mesenchymal to epithelial transition
0.59	GO:0035457	cellular response to interferon-alpha
0.58	GO:2000702	regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
0.58	GO:2000733	regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation

0.75	GO:0000976	transcription regulatory region sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.59	GO:0071837	HMG box domain binding
0.55	GO:0005134	interleukin-2 receptor binding
0.55	GO:0001047	core promoter binding
0.55	GO:0001012	RNA polymerase II regulatory region DNA binding
0.54	GO:0003713	transcription coactivator activity
0.53	GO:0035326	enhancer binding
0.52	GO:0008134	transcription factor binding

0.60	GO:0005634	nucleus
0.50	GO:0000785	chromatin
0.48	GO:0070013	intracellular organelle lumen
0.45	GO:0005667	transcription factor complex
0.30	GO:0016021	integral component of membrane

sp|P23786|CPT2_HUMAN
Carnitine O-palmitoyltransferase 2, mitochondrial
Search

CPT2

0.89	Mitochondrial carnitine palmitoyltransferase II

0.40	GO:0006635	fatty acid beta-oxidation
0.37	GO:0015909	long-chain fatty acid transport
0.36	GO:1902001	fatty acid transmembrane transport
0.36	GO:0032365	intracellular lipid transport
0.35	GO:1990542	mitochondrial transmembrane transport
0.35	GO:0019216	regulation of lipid metabolic process

0.61

GO:0016746

transferase activity, transferring acyl groups

0.54	GO:0005730	nucleolus
0.52	GO:0005654	nucleoplasm
0.48	GO:0005739	mitochondrion
0.38	GO:0019866	organelle inner membrane

0.61

GO:0016746

sp|P23919|KTHY_HUMAN
Thymidylate kinase
Search

DTYMK

0.45	Deoxythymidylate kinase

0.79	GO:0006233	dTDP biosynthetic process
0.69	GO:0046939	nucleotide phosphorylation
0.52	GO:0006227	dUDP biosynthetic process
0.51	GO:0071363	cellular response to growth factor stimulus
0.48	GO:0006235	dTTP biosynthetic process
0.40	GO:0045445	myoblast differentiation
0.40	GO:0046940	nucleoside monophosphate phosphorylation
0.40	GO:0043627	response to estrogen
0.40	GO:0046686	response to cadmium ion
0.35	GO:0015949	nucleobase-containing small molecule interconversion

0.79	GO:0004798	thymidylate kinase activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0009041	uridylate kinase activity
0.40	GO:0050145	nucleoside phosphate kinase activity
0.38	GO:0004550	nucleoside diphosphate kinase activity
0.31	GO:0016787	hydrolase activity

0.39	GO:0005758	mitochondrial intermembrane space
0.38	GO:0005759	mitochondrial matrix
0.35	GO:0005634	nucleus
0.34	GO:0005829	cytosol

0.79

EC:2.7.4.9

GO:0004798

sp|P23921|RIR1_HUMAN
Ribonucleoside-diphosphate reductase large subunit
Search

RRM1

0.55	Ribonucleoside-diphosphate reductase large subunit

0.66	GO:0006260	DNA replication
0.55	GO:0051290	protein heterotetramerization
0.52	GO:0055114	oxidation-reduction process
0.49	GO:0009263	deoxyribonucleotide biosynthetic process
0.38	GO:0021846	cell proliferation in forebrain
0.38	GO:0008584	male gonad development
0.38	GO:0060041	retina development in camera-type eye
0.38	GO:0010212	response to ionizing radiation
0.36	GO:0000278	mitotic cell cycle
0.36	GO:0006206	pyrimidine nucleobase metabolic process

0.75	GO:0061731	ribonucleoside-diphosphate reductase activity
0.54	GO:0097718	disordered domain specific binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0042802	identical protein binding

0.52	GO:0005971	ribonucleoside-diphosphate reductase complex
0.37	GO:0043025	neuronal cell body
0.37	GO:0005635	nuclear envelope
0.36	GO:0070062	extracellular exosome
0.36	GO:0042995	cell projection
0.33	GO:0031463	Cul3-RING ubiquitin ligase complex

sp|P23942|PRPH2_HUMAN
Peripherin-2
Search

PRPH2

0.97	Retinal degeneration, slow (Retinitis pigmentosa 7)

0.78	GO:0007601	visual perception
0.55	GO:0060041	retina development in camera-type eye
0.44	GO:0007166	cell surface receptor signaling pathway
0.40	GO:0007155	cell adhesion
0.35	GO:1903525	regulation of membrane tubulation
0.35	GO:0009645	response to low light intensity stimulus
0.35	GO:0051289	protein homotetramerization
0.34	GO:0051258	protein polymerization

0.34	GO:0042803	protein homodimerization activity
0.34	GO:0015631	tubulin binding

0.56	GO:0001750	photoreceptor outer segment
0.42	GO:0005887	integral component of plasma membrane
0.35	GO:0055037	recycling endosome
0.34	GO:0005795	Golgi stack
0.34	GO:0005783	endoplasmic reticulum
0.33	GO:0043234	protein complex

sp|P23945|FSHR_HUMAN
Follicle-stimulating hormone receptor
Search

FSHR

0.83	Follicle-stimulating hormone receptor

0.86	GO:0042699	follicle-stimulating hormone signaling pathway
0.64	GO:0001545	primary ovarian follicle growth
0.60	GO:0060408	regulation of acetylcholine metabolic process
0.60	GO:0045670	regulation of osteoclast differentiation
0.59	GO:0060011	Sertoli cell proliferation
0.59	GO:0009992	cellular water homeostasis
0.58	GO:0035093	spermatogenesis, exchange of chromosomal proteins
0.58	GO:0045779	negative regulation of bone resorption
0.58	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
0.58	GO:0060009	Sertoli cell development

0.86	GO:0004963	follicle-stimulating hormone receptor activity
0.71	GO:0004930	G-protein coupled receptor activity
0.45	GO:0001653	peptide receptor activity
0.41	GO:0017046	peptide hormone binding
0.35	GO:0005515	protein binding

0.54	GO:0005886	plasma membrane
0.51	GO:0009986	cell surface
0.38	GO:0005768	endosome
0.30	GO:0016021	integral component of membrane

sp|P23946|CMA1_HUMAN
Chymase
Search

CMA1

0.95	Skeletal muscle neutral protease mekratin

0.61	GO:0006508	proteolysis
0.57	GO:0042222	interleukin-1 biosynthetic process
0.55	GO:0034769	basement membrane disassembly
0.55	GO:0032611	interleukin-1 beta production
0.51	GO:0001909	leukocyte mediated cytotoxicity
0.50	GO:0008626	granzyme-mediated apoptotic signaling pathway
0.50	GO:0002228	natural killer cell mediated immunity
0.39	GO:1901701	cellular response to oxygen-containing compound
0.39	GO:0071310	cellular response to organic substance
0.39	GO:0030901	midbrain development

0.69	GO:0004252	serine-type endopeptidase activity
0.38	GO:0042277	peptide binding
0.38	GO:0008201	heparin binding
0.34	GO:0005515	protein binding

0.56	GO:0030141	secretory granule
0.49	GO:0031012	extracellular matrix
0.37	GO:0010494	cytoplasmic stress granule
0.36	GO:0005615	extracellular space
0.35	GO:0005766	primary lysosome
0.35	GO:0060205	cytoplasmic vesicle lumen
0.34	GO:0005775	vacuolar lumen
0.34	GO:0001772	immunological synapse
0.34	GO:1903561	extracellular vesicle
0.34	GO:0009986	cell surface

0.69

GO:0004252

sp|P23975|SC6A2_HUMAN
Sodium-dependent noradrenaline transporter
Search

SLC6A2

0.75	Sodium-dependent noradrenaline transporter

0.76	GO:0006836	neurotransmitter transport
0.55	GO:0055085	transmembrane transport
0.51	GO:0015874	norepinephrine transport
0.50	GO:0090494	dopamine uptake
0.50	GO:0001963	synaptic transmission, dopaminergic
0.47	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.46	GO:0048265	response to pain
0.44	GO:0001505	regulation of neurotransmitter levels
0.44	GO:0098657	import into cell
0.43	GO:0051649	establishment of localization in cell

0.79	GO:0005328	neurotransmitter:sodium symporter activity
0.51	GO:0005333	norepinephrine transmembrane transporter activity
0.50	GO:0005329	dopamine transmembrane transporter activity
0.46	GO:0043014	alpha-tubulin binding
0.45	GO:0048487	beta-tubulin binding
0.38	GO:0046872	metal ion binding

0.63	GO:0005887	integral component of plasma membrane
0.46	GO:0043005	neuron projection
0.44	GO:0045121	membrane raft
0.42	GO:0009986	cell surface

sp|P24001|IL32_HUMAN
Interleukin-32
Search

IL32

0.51	Matrix metalloproteinase

0.74	GO:0006955	immune response
0.46	GO:0019221	cytokine-mediated signaling pathway
0.45	GO:0010469	regulation of receptor activity
0.44	GO:0007155	cell adhesion
0.44	GO:0006952	defense response
0.37	GO:0006508	proteolysis

0.46	GO:0005125	cytokine activity
0.39	GO:0008237	metallopeptidase activity
0.36	GO:0046872	metal ion binding

0.44	GO:0005615	extracellular space
0.42	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|P24043|LAMA2_HUMAN
Laminin subunit alpha-2
Search

0.56	Laminin subunit alpha 2

0.83	GO:0045995	regulation of embryonic development
0.79	GO:0030334	regulation of cell migration
0.76	GO:0030155	regulation of cell adhesion
0.70	GO:0007155	cell adhesion
0.39	GO:0032224	positive regulation of synaptic transmission, cholinergic
0.38	GO:0022008	neurogenesis
0.37	GO:0048468	cell development
0.37	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.37	GO:0120036	plasma membrane bounded cell projection organization
0.36	GO:0006935	chemotaxis

0.72	GO:0005102	receptor binding
0.54	GO:0008022	protein C-terminus binding
0.35	GO:0005201	extracellular matrix structural constituent

0.59	GO:0005606	laminin-1 complex
0.59	GO:0005608	laminin-3 complex
0.51	GO:0005615	extracellular space
0.38	GO:0042383	sarcolemma
0.33	GO:0043197	dendritic spine
0.32	GO:1903561	extracellular vesicle
0.30	GO:0031224	intrinsic component of membrane

sp|P24046|GBRR1_HUMAN
Gamma-aminobutyric acid receptor subunit rho-1
Search

GABRR1

0.96	LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit rho-1

0.59	GO:0007165	signal transduction
0.59	GO:0034220	ion transmembrane transport
0.44	GO:0007601	visual perception
0.38	GO:0006821	chloride transport
0.35	GO:0007268	chemical synaptic transmission

0.75	GO:0004890	GABA-A receptor activity
0.74	GO:0005230	extracellular ligand-gated ion channel activity
0.38	GO:0005254	chloride channel activity
0.34	GO:0019904	protein domain specific binding
0.34	GO:0042803	protein homodimerization activity
0.34	GO:0046982	protein heterodimerization activity

0.55	GO:0005886	plasma membrane
0.51	GO:1902711	GABA-A receptor complex
0.39	GO:0034707	chloride channel complex
0.38	GO:0098794	postsynapse
0.38	GO:0030054	cell junction

sp|P24071|FCAR_HUMAN
Immunoglobulin alpha Fc receptor
Search

FCAR

0.97	Immunoglobulin alpha Fc receptor

0.47	GO:0033031	positive regulation of neutrophil apoptotic process
0.47	GO:0038093	Fc receptor signaling pathway
0.46	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus
0.46	GO:0035457	cellular response to interferon-alpha
0.46	GO:1903209	positive regulation of oxidative stress-induced cell death
0.46	GO:0071354	cellular response to interleukin-6
0.46	GO:0002274	myeloid leukocyte activation
0.46	GO:0002446	neutrophil mediated immunity
0.45	GO:0071346	cellular response to interferon-gamma
0.45	GO:0071356	cellular response to tumor necrosis factor

0.49	GO:0019766	IgA receptor activity
0.47	GO:0019862	IgA binding
0.40	GO:0001540	amyloid-beta binding
0.38	GO:0005057	signal transducer activity, downstream of receptor
0.35	GO:0015026	coreceptor activity
0.35	GO:0042803	protein homodimerization activity
0.34	GO:0005102	receptor binding

0.46	GO:0005886	plasma membrane
0.44	GO:0101003	ficolin-1-rich granule membrane
0.44	GO:0035579	specific granule membrane
0.44	GO:0070821	tertiary granule membrane
0.38	GO:0005576	extracellular region
0.37	GO:0106003	amyloid-beta complex
0.33	GO:0098796	membrane protein complex
0.30	GO:0016021	integral component of membrane

sp|P24158|PRTN3_HUMAN
Myeloblastin
Search

ELANE

0.88	Serine protease harobin

0.61	GO:0050900	leukocyte migration
0.61	GO:0006508	proteolysis
0.59	GO:0002812	biosynthetic process of antibacterial peptides active against Gram-negative bacteria
0.58	GO:0070947	neutrophil mediated killing of fungus
0.58	GO:0045079	negative regulation of chemokine biosynthetic process
0.58	GO:0070944	neutrophil mediated killing of bacterium
0.58	GO:0045415	negative regulation of interleukin-8 biosynthetic process
0.57	GO:0006909	phagocytosis
0.57	GO:0002438	acute inflammatory response to antigenic stimulus
0.57	GO:0045416	positive regulation of interleukin-8 biosynthetic process

0.69	GO:0004252	serine-type endopeptidase activity
0.55	GO:0001106	RNA polymerase II transcription corepressor activity
0.54	GO:0019899	enzyme binding
0.53	GO:0019955	cytokine binding
0.53	GO:0008201	heparin binding
0.47	GO:0005102	receptor binding
0.35	GO:0043395	heparan sulfate proteoglycan binding
0.35	GO:0030552	cAMP binding
0.34	GO:0005249	voltage-gated potassium channel activity
0.33	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

0.60	GO:0030141	secretory granule
0.56	GO:0044421	extracellular region part
0.55	GO:0005766	primary lysosome
0.54	GO:0060205	cytoplasmic vesicle lumen
0.53	GO:0005775	vacuolar lumen
0.52	GO:0017053	transcriptional repressor complex
0.52	GO:0044853	plasma membrane raft
0.50	GO:0009986	cell surface
0.45	GO:0005829	cytosol
0.35	GO:0005765	lysosomal membrane

0.69

GO:0004252

sp|P24278|ZBT25_HUMAN
Zinc finger and BTB domain-containing protein 25
Search

ZBTB25

0.97	Zinc finger and BTB domain-containing protein 25

0.43	GO:0010467	gene expression
0.43	GO:0000122	negative regulation of transcription by RNA polymerase II
0.35	GO:0097659	nucleic acid-templated transcription
0.34	GO:0034645	cellular macromolecule biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.34	GO:0005515	protein binding
0.34	GO:0046872	metal ion binding
0.34	GO:0003700	DNA binding transcription factor activity

0.52	GO:0005654	nucleoplasm
0.40	GO:0005737	cytoplasm

sp|P24298|ALAT1_HUMAN
Alanine aminotransferase 1
Search

GPT

0.87	Mitochondrial alanine aminotransferase

0.51	GO:0042851	L-alanine metabolic process
0.50	GO:0006103	2-oxoglutarate metabolic process
0.49	GO:0009058	biosynthetic process
0.42	GO:0009080	pyruvate family amino acid catabolic process

0.67	GO:0030170	pyridoxal phosphate binding
0.61	GO:0008483	transaminase activity

0.46	GO:0005615	extracellular space
0.41	GO:0005739	mitochondrion
0.36	GO:1903561	extracellular vesicle
0.34	GO:0005829	cytosol
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part

0.61

EC:2.6.1

GO:0008483

sp|P24310|CX7A1_HUMAN
Cytochrome c oxidase subunit 7A1, mitochondrial
Search

0.97	Cytochrome c oxidase subunit VIIa polypeptide 1

0.63	GO:1902600	hydrogen ion transmembrane transport
0.61	GO:0022900	electron transport chain
0.34	GO:0006879	cellular iron ion homeostasis
0.34	GO:0006826	iron ion transport
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression

0.65	GO:0015002	heme-copper terminal oxidase activity
0.65	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.62	GO:0009055	electron transfer activity
0.34	GO:0008199	ferric iron binding
0.32	GO:0003676	nucleic acid binding

0.79	GO:0005746	mitochondrial respiratory chain
0.36	GO:0070062	extracellular exosome
0.35	GO:0045277	respiratory chain complex IV
0.30	GO:0016021	integral component of membrane

0.65

GO:0016676

sp|P24311|COX7B_HUMAN
Cytochrome c oxidase subunit 7B, mitochondrial
Search

0.97	Cytochrome c oxidase polypeptide VIIb

0.63	GO:1902600	hydrogen ion transmembrane transport
0.61	GO:0022900	electron transport chain
0.48	GO:0007417	central nervous system development
0.35	GO:0060003	copper ion export
0.34	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.34	GO:0006119	oxidative phosphorylation
0.34	GO:0009060	aerobic respiration

0.65	GO:0015002	heme-copper terminal oxidase activity
0.65	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.62	GO:0009055	electron transfer activity
0.35	GO:0004008	copper-exporting ATPase activity
0.34	GO:0005507	copper ion binding
0.33	GO:1901265	nucleoside phosphate binding
0.32	GO:0036094	small molecule binding

0.79	GO:0005746	mitochondrial respiratory chain
0.46	GO:0045277	respiratory chain complex IV
0.30	GO:0016021	integral component of membrane

0.65

GO:0016676

sp|P24347|MMP11_HUMAN
Stromelysin-3
Search

MMP11

0.72	Matrix metalloproteinase

0.69	GO:0007275	multicellular organism development
0.61	GO:0006508	proteolysis
0.60	GO:0030574	collagen catabolic process
0.59	GO:0071711	basement membrane organization
0.59	GO:0045599	negative regulation of fat cell differentiation
0.58	GO:0030199	collagen fibril organization
0.36	GO:0022617	extracellular matrix disassembly
0.34	GO:0006338	chromatin remodeling
0.33	GO:0050900	leukocyte migration
0.33	GO:0001503	ossification

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.34	GO:0004252	serine-type endopeptidase activity

0.74	GO:0031012	extracellular matrix
0.36	GO:0005796	Golgi lumen
0.34	GO:0000228	nuclear chromosome
0.32	GO:0005581	collagen trimer
0.30	GO:0016020	membrane

0.70

GO:0004222

sp|P24385|CCND1_HUMAN
G1/S-specific cyclin-D1
Search

CCND1

0.97	G1/S-specific cyclin-D1

0.67	GO:0007049	cell cycle
0.59	GO:2000045	regulation of G1/S transition of mitotic cell cycle
0.58	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
0.58	GO:0070141	response to UV-A
0.57	GO:1901992	positive regulation of mitotic cell cycle phase transition
0.56	GO:0044783	G1 DNA damage checkpoint
0.56	GO:0071157	negative regulation of cell cycle arrest
0.55	GO:1902807	negative regulation of cell cycle G1/S phase transition
0.55	GO:0033601	positive regulation of mammary gland epithelial cell proliferation
0.55	GO:0097421	liver regeneration

0.55	GO:0070064	proline-rich region binding
0.54	GO:0019901	protein kinase binding
0.53	GO:0003714	transcription corepressor activity
0.53	GO:0042826	histone deacetylase binding
0.51	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.48	GO:0008134	transcription factor binding
0.44	GO:0004672	protein kinase activity
0.39	GO:0032403	protein complex binding
0.35	GO:0060089	molecular transducer activity

0.61	GO:0005634	nucleus
0.58	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
0.53	GO:0017053	transcriptional repressor complex
0.51	GO:0005923	bicellular tight junction
0.48	GO:0070013	intracellular organelle lumen
0.43	GO:0044446	intracellular organelle part
0.41	GO:0005829	cytosol
0.40	GO:0005694	chromosome
0.40	GO:0012505	endomembrane system
0.38	GO:0031090	organelle membrane

0.51

GO:0016538

sp|P24386|RAE1_HUMAN
Rab proteins geranylgeranyltransferase component A 1
Search

CHM

0.94	Rab proteins geranylgeranyltransferase component A 1

0.84	GO:0018344	protein geranylgeranylation
0.77	GO:0007264	small GTPase mediated signal transduction
0.69	GO:0006886	intracellular protein transport
0.69	GO:0050790	regulation of catalytic activity
0.48	GO:0090150	establishment of protein localization to membrane
0.43	GO:0048798	swim bladder inflation
0.42	GO:0050935	iridophore differentiation
0.42	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
0.41	GO:0010842	retina layer formation
0.41	GO:0042491	inner ear auditory receptor cell differentiation

0.83	GO:0005092	GDP-dissociation inhibitor activity
0.55	GO:0017137	Rab GTPase binding
0.44	GO:0016740	transferase activity
0.39	GO:0005096	GTPase activator activity
0.36	GO:0140096	catalytic activity, acting on a protein
0.34	GO:0032403	protein complex binding
0.34	GO:0004930	G-protein coupled receptor activity

0.84	GO:0005968	Rab-protein geranylgeranyltransferase complex
0.49	GO:0005829	cytosol
0.40	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.44

GO:0016740

sp|P24387|CRHBP_HUMAN
Corticotropin-releasing factor-binding protein
Search

CRHBP

0.96	Corticotropin releasing hormone binding protein (Fragment)

0.64	GO:1900010	regulation of corticotropin-releasing hormone receptor activity
0.64	GO:0051460	negative regulation of corticotropin secretion
0.62	GO:0002125	maternal aggressive behavior
0.62	GO:0035865	cellular response to potassium ion
0.61	GO:0097211	cellular response to gonadotropin-releasing hormone
0.61	GO:0071392	cellular response to estradiol stimulus
0.60	GO:2000310	regulation of NMDA receptor activity
0.60	GO:0001963	synaptic transmission, dopaminergic
0.60	GO:0071391	cellular response to estrogen stimulus
0.60	GO:0048149	behavioral response to ethanol

0.86	GO:0051424	corticotropin-releasing hormone binding
0.33	GO:0005515	protein binding

0.62	GO:0005576	extracellular region
0.56	GO:0030141	secretory granule
0.46	GO:0005634	nucleus
0.41	GO:0043196	varicosity
0.41	GO:0005767	secondary lysosome
0.40	GO:0005771	multivesicular body
0.40	GO:0043204	perikaryon
0.40	GO:0043679	axon terminus
0.39	GO:0030425	dendrite
0.38	GO:0005874	microtubule

sp|P24390|ERD21_HUMAN
ER lumen protein-retaining receptor 1
Search

KDELR1

0.66	ER lumen protein-retaining receptor

0.84	GO:0006621	protein retention in ER lumen
0.64	GO:0015031	protein transport
0.52	GO:0002369	T cell cytokine production
0.52	GO:0070231	T cell apoptotic process
0.50	GO:0030217	T cell differentiation
0.41	GO:0016192	vesicle-mediated transport
0.34	GO:0046907	intracellular transport
0.33	GO:0006629	lipid metabolic process

0.84	GO:0046923	ER retention sequence binding
0.32	GO:0016787	hydrolase activity
0.32	GO:0003676	nucleic acid binding

0.71	GO:0005789	endoplasmic reticulum membrane
0.51	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.50	GO:0005801	cis-Golgi network
0.45	GO:0005794	Golgi apparatus
0.40	GO:0030663	COPI-coated vesicle membrane
0.35	GO:0070062	extracellular exosome
0.35	GO:0030133	transport vesicle
0.30	GO:0016021	integral component of membrane

0.32

GO:0016787

sp|P24394|IL4RA_HUMAN
Interleukin-4 receptor subunit alpha
Search

IL4R

0.95	Interleukin-4 receptor subunit alpha

0.86	GO:0002532	production of molecular mediator involved in inflammatory response
0.79	GO:0019221	cytokine-mediated signaling pathway
0.61	GO:0045626	negative regulation of T-helper 1 cell differentiation
0.59	GO:0045630	positive regulation of T-helper 2 cell differentiation
0.58	GO:0090197	positive regulation of chemokine secretion
0.58	GO:0043306	positive regulation of mast cell degranulation
0.58	GO:1901741	positive regulation of myoblast fusion
0.58	GO:0043032	positive regulation of macrophage activation
0.58	GO:0042832	defense response to protozoan
0.57	GO:0002639	positive regulation of immunoglobulin production

0.81	GO:0004896	cytokine receptor activity
0.38	GO:0005057	signal transducer activity, downstream of receptor
0.37	GO:0005515	protein binding
0.31	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.58	GO:0043235	receptor complex
0.39	GO:0005576	extracellular region
0.37	GO:0005886	plasma membrane
0.32	GO:0008021	synaptic vesicle
0.30	GO:0016021	integral component of membrane

sp|P24462|CP3A7_HUMAN
Cytochrome P450 3A7
Search

0.97	Cytochrome P450 family 3 subfamily A polypeptide 4

0.53	GO:0055114	oxidation-reduction process
0.49	GO:0009822	alkaloid catabolic process
0.49	GO:0002933	lipid hydroxylation
0.47	GO:0008202	steroid metabolic process
0.45	GO:0070988	demethylation
0.43	GO:0042445	hormone metabolic process
0.42	GO:0016098	monoterpenoid metabolic process
0.42	GO:0042738	exogenous drug catabolic process
0.41	GO:0042362	fat-soluble vitamin biosynthetic process
0.41	GO:1901615	organic hydroxy compound metabolic process

0.78	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.52	GO:0008395	steroid hydroxylase activity
0.43	GO:0030343	vitamin D3 25-hydroxylase activity
0.42	GO:0034875	caffeine oxidase activity
0.42	GO:0070576	vitamin D 24-hydroxylase activity
0.40	GO:0005496	steroid binding
0.38	GO:0019899	enzyme binding
0.37	GO:0019825	oxygen binding

0.42	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0031090	organelle membrane
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.78

GO:0016712

sp|P24468|COT2_HUMAN
COUP transcription factor 2
Search

NR2F2

0.81	Nuclear receptor subfamily 2 group F member 1-A

0.80	GO:0030522	intracellular receptor signaling pathway
0.79	GO:0043401	steroid hormone mediated signaling pathway
0.71	GO:0060838	lymphatic endothelial cell fate commitment
0.68	GO:0060850	regulation of transcription involved in cell fate commitment
0.61	GO:0001568	blood vessel development
0.61	GO:0009956	radial pattern formation
0.60	GO:0000122	negative regulation of transcription by RNA polymerase II
0.60	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
0.60	GO:0001937	negative regulation of endothelial cell proliferation
0.60	GO:0010596	negative regulation of endothelial cell migration

0.82	GO:0004879	nuclear receptor activity
0.80	GO:0003707	steroid hormone receptor activity
0.63	GO:0043565	sequence-specific DNA binding
0.61	GO:0001972	retinoic acid binding
0.61	GO:0008270	zinc ion binding
0.54	GO:0042803	protein homodimerization activity
0.47	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.45	GO:0001012	RNA polymerase II regulatory region DNA binding
0.44	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.54	GO:0005829	cytosol
0.53	GO:0070013	intracellular organelle lumen
0.47	GO:0044446	intracellular organelle part

sp|P24522|GA45A_HUMAN
Growth arrest and DNA damage-inducible protein GADD45 alpha
Search

GADD45A

0.97	Growth arrest and DNA-damage-inducible protein alpha

0.72	GO:0051726	regulation of cell cycle
0.65	GO:1900745	positive regulation of p38MAPK cascade
0.64	GO:0000185	activation of MAPKKK activity
0.62	GO:0046330	positive regulation of JNK cascade
0.61	GO:0006950	response to stress
0.58	GO:0043065	positive regulation of apoptotic process
0.58	GO:0071260	cellular response to mechanical stimulus
0.57	GO:0071479	cellular response to ionizing radiation
0.57	GO:2000379	positive regulation of reactive oxygen species metabolic process
0.55	GO:0007098	centrosome cycle

0.57	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
0.57	GO:0047485	protein N-terminus binding
0.53	GO:0019900	kinase binding
0.52	GO:0042803	protein homodimerization activity
0.52	GO:0046982	protein heterodimerization activity
0.33	GO:0003735	structural constituent of ribosome

0.60	GO:0005634	nucleus
0.48	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.42	GO:0005737	cytoplasm
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0043232	intracellular non-membrane-bounded organelle

sp|P24530|EDNRB_HUMAN
Endothelin B receptor
Search

EDNRB

0.97	Endothelin receptor type B

0.82	GO:0086100	endothelin receptor signaling pathway
0.81	GO:0048484	enteric nervous system development
0.79	GO:0042310	vasoconstriction
0.77	GO:0008217	regulation of blood pressure
0.61	GO:0035645	enteric smooth muscle cell differentiation
0.61	GO:0007497	posterior midgut development
0.60	GO:0014043	negative regulation of neuron maturation
0.59	GO:0050931	pigment cell differentiation
0.59	GO:0048246	macrophage chemotaxis
0.59	GO:0014821	phasic smooth muscle contraction

0.83	GO:0004962	endothelin receptor activity
0.58	GO:0017046	peptide hormone binding
0.42	GO:0031702	type 1 angiotensin receptor binding

0.43	GO:0005886	plasma membrane
0.39	GO:0098857	membrane microdomain
0.39	GO:0031965	nuclear membrane
0.30	GO:0016021	integral component of membrane

sp|P24534|EF1B_HUMAN
Elongation factor 1-beta
Search

EEF1B2

0.66	Eukaryotic translation elongation factor 1 beta 2

0.70	GO:0006414	translational elongation
0.37	GO:0045471	response to ethanol
0.34	GO:0071479	cellular response to ionizing radiation

0.71	GO:0003746	translation elongation factor activity
0.35	GO:0005515	protein binding

0.83	GO:0005853	eukaryotic translation elongation factor 1 complex
0.44	GO:0005783	endoplasmic reticulum
0.34	GO:0005634	nucleus
0.34	GO:0005829	cytosol
0.33	GO:0043233	organelle lumen
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.32	GO:0044446	intracellular organelle part

sp|P24539|AT5F1_HUMAN
ATP synthase F(0) complex subunit B1, mitochondrial
Search

ATP5F1

0.42	ATP synthase peripheral stalk-membrane subunit b

0.70	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.70	GO:0006754	ATP biosynthetic process
0.43	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.38	GO:0021762	substantia nigra development
0.35	GO:0042407	cristae formation
0.35	GO:0006839	mitochondrial transport
0.34	GO:0046907	intracellular transport

0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.44	GO:0016887	ATPase activity
0.43	GO:0022853	active ion transmembrane transporter activity
0.42	GO:0015399	primary active transmembrane transporter activity
0.33	GO:0005515	protein binding

0.78	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
0.50	GO:0043209	myelin sheath
0.46	GO:0005654	nucleoplasm
0.36	GO:0070062	extracellular exosome
0.34	GO:0005759	mitochondrial matrix
0.30	GO:0016021	integral component of membrane

0.44

GO:0016887

sp|P24557|THAS_HUMAN
Thromboxane-A synthase
Search

TBXAS1

0.96	Thromboxane-A synthase

0.53	GO:0055114	oxidation-reduction process
0.44	GO:0046457	prostanoid biosynthetic process
0.44	GO:0006693	prostaglandin metabolic process
0.39	GO:0030644	cellular chloride ion homeostasis
0.38	GO:0045907	positive regulation of vasoconstriction
0.38	GO:0070542	response to fatty acid
0.38	GO:0045471	response to ethanol
0.36	GO:0019369	arachidonic acid metabolic process

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.65	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.62	GO:0004796	thromboxane-A synthase activity
0.38	GO:0036134	12-hydroxyheptadecatrienoic acid synthase activity

0.40	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.68	EC:1.14	GO:0016705
0.62	KEGG:R02268	GO:0004796

sp|P24588|AKAP5_HUMAN
A-kinase anchor protein 5
Search

AKAP5

0.96	A-kinase anchoring protein 5

0.83	GO:0010738	regulation of protein kinase A signaling
0.82	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.70	GO:0006605	protein targeting
0.44	GO:0033159	negative regulation of protein import into nucleus, translocation
0.44	GO:1903538	regulation of meiotic cell cycle process involved in oocyte maturation

0.85	GO:0030346	protein phosphatase 2B binding
0.85	GO:0008179	adenylate cyclase binding
0.85	GO:0035254	glutamate receptor binding
0.84	GO:0034237	protein kinase A regulatory subunit binding
0.84	GO:0097110	scaffold protein binding
0.77	GO:0017124	SH3 domain binding

0.45	GO:0005622	intracellular
0.36	GO:0005886	plasma membrane

sp|P24592|IBP6_HUMAN
Insulin-like growth factor-binding protein 6
Search

IGFBP6

0.97	Insulin like growth factor binding protein 6

0.78	GO:0001558	regulation of cell growth
0.53	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway
0.38	GO:0090090	negative regulation of canonical Wnt signaling pathway
0.38	GO:0008285	negative regulation of cell proliferation
0.36	GO:0044342	type B pancreatic cell proliferation
0.36	GO:0032268	regulation of cellular protein metabolic process
0.36	GO:0010906	regulation of glucose metabolic process
0.35	GO:0052548	regulation of endopeptidase activity
0.35	GO:0051346	negative regulation of hydrolase activity
0.35	GO:1902533	positive regulation of intracellular signal transduction

0.84	GO:0005520	insulin-like growth factor binding
0.37	GO:0005102	receptor binding
0.36	GO:0004867	serine-type endopeptidase inhibitor activity
0.33	GO:0008374	O-acyltransferase activity
0.32	GO:0004252	serine-type endopeptidase activity

0.74	GO:0042568	insulin-like growth factor binary complex
0.40	GO:0070062	extracellular exosome
0.39	GO:0005794	Golgi apparatus
0.33	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.33

GO:0008374

sp|P24593|IBP5_HUMAN
Insulin-like growth factor-binding protein 5
Search

IGFBP5

0.95	Insulin like growth factor binding protein 5

0.74	GO:0001558	regulation of cell growth
0.63	GO:0060416	response to growth hormone
0.61	GO:1904205	negative regulation of skeletal muscle hypertrophy
0.61	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway
0.59	GO:0044342	type B pancreatic cell proliferation
0.59	GO:0060056	mammary gland involution
0.58	GO:0014912	negative regulation of smooth muscle cell migration
0.57	GO:0048286	lung alveolus development
0.57	GO:0045668	negative regulation of osteoblast differentiation
0.57	GO:1901862	negative regulation of muscle tissue development

0.84	GO:0005520	insulin-like growth factor binding
0.61	GO:0001968	fibronectin binding

0.66	GO:0005576	extracellular region
0.59	GO:0036454	growth factor complex
0.35	GO:0005788	endoplasmic reticulum lumen

sp|P24666|PPAC_HUMAN
Low molecular weight phosphotyrosine protein phosphatase
Search

ACP1

0.61	Low molecular weight phosphotyrosine protein phosphatase

0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.44	GO:0048793	pronephros development
0.34	GO:0098916	anterograde trans-synaptic signaling

0.85	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity
0.77	GO:0003993	acid phosphatase activity
0.34	GO:0017124	SH3 domain binding

0.51	GO:0042383	sarcolemma
0.49	GO:0009898	cytoplasmic side of plasma membrane
0.48	GO:0005737	cytoplasm
0.36	GO:0070062	extracellular exosome
0.34	GO:0043005	neuron projection
0.30	GO:0016021	integral component of membrane

0.77

EC:3.1.3.2

GO:0003993

sp|P24723|KPCL_HUMAN
Protein kinase C eta type
Search

PRKCH

0.94	Protein kinase C eta type

0.62	GO:0006468	protein phosphorylation
0.62	GO:0010744	positive regulation of macrophage derived foam cell differentiation
0.61	GO:0035556	intracellular signal transduction
0.61	GO:0045618	positive regulation of keratinocyte differentiation
0.61	GO:0034351	negative regulation of glial cell apoptotic process
0.61	GO:0060252	positive regulation of glial cell proliferation
0.61	GO:0050861	positive regulation of B cell receptor signaling pathway
0.61	GO:2000810	regulation of bicellular tight junction assembly
0.57	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.49	GO:0018209	peptidyl-serine modification

0.80	GO:0004697	protein kinase C activity
0.60	GO:0017160	Ral GTPase binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0046872	metal ion binding

0.54	GO:0005911	cell-cell junction
0.50	GO:0005829	cytosol
0.43	GO:0005886	plasma membrane
0.37	GO:0070062	extracellular exosome
0.33	GO:0048471	perinuclear region of cytoplasm
0.32	GO:0005856	cytoskeleton
0.32	GO:0005634	nucleus

0.80

EC:2.7.11.13

GO:0004697

sp|P24752|THIL_HUMAN
Acetyl-CoA acetyltransferase, mitochondrial
Search

ACAT1

0.40	Acetyl-CoA acetyltransferase

0.60	GO:1902860	propionyl-CoA biosynthetic process
0.58	GO:0006550	isoleucine catabolic process
0.57	GO:0046356	acetyl-CoA catabolic process
0.54	GO:0046952	ketone body catabolic process
0.51	GO:0006085	acetyl-CoA biosynthetic process
0.50	GO:0015937	coenzyme A biosynthetic process
0.46	GO:0006635	fatty acid beta-oxidation
0.41	GO:0072229	metanephric proximal convoluted tubule development
0.40	GO:0060612	adipose tissue development
0.39	GO:0001889	liver development

0.64	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
0.51	GO:0016885	ligase activity, forming carbon-carbon bonds
0.47	GO:0016830	carbon-carbon lyase activity
0.38	GO:0042803	protein homodimerization activity
0.37	GO:0019899	enzyme binding
0.36	GO:0046872	metal ion binding
0.35	GO:0050662	coenzyme binding
0.34	GO:0005044	scavenger receptor activity
0.33	GO:0004222	metalloendopeptidase activity
0.33	GO:0004252	serine-type endopeptidase activity

0.46	GO:0005739	mitochondrion
0.45	GO:0019866	organelle inner membrane
0.36	GO:0043233	organelle lumen
0.36	GO:0070062	extracellular exosome
0.34	GO:0005777	peroxisome
0.34	GO:0031012	extracellular matrix
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.64

GO:0016747

sp|P24821|TENA_HUMAN
Tenascin
Search

0.45	Tenascin C

0.76	GO:0042127	regulation of cell proliferation
0.72	GO:0007155	cell adhesion
0.50	GO:0060739	mesenchymal-epithelial cell signaling involved in prostate gland development
0.50	GO:0031103	axon regeneration
0.48	GO:0060740	prostate gland epithelium morphogenesis
0.47	GO:0007528	neuromuscular junction development
0.43	GO:0048522	positive regulation of cellular process
0.43	GO:0010628	positive regulation of gene expression
0.39	GO:0021554	optic nerve development
0.39	GO:0030517	negative regulation of axon extension

0.49

GO:0045545

syndecan binding

0.74	GO:0031012	extracellular matrix
0.43	GO:0005615	extracellular space
0.37	GO:0005925	focal adhesion
0.30	GO:0043226	organelle
0.30	GO:0005737	cytoplasm
0.30	GO:0016020	membrane
0.30	GO:0012505	endomembrane system
0.30	GO:0031974	membrane-enclosed lumen

sp|P24844|MYL9_HUMAN
Myosin regulatory light polypeptide 9
Search

MYL9

0.94	Regulatory myosin light chain long version

0.45	GO:0072659	protein localization to plasma membrane
0.42	GO:0050793	regulation of developmental process
0.41	GO:0065008	regulation of biological quality
0.40	GO:0051128	regulation of cellular component organization
0.37	GO:0034109	homotypic cell-cell adhesion
0.37	GO:0050817	coagulation
0.37	GO:0042060	wound healing
0.36	GO:0001775	cell activation
0.36	GO:0031032	actomyosin structure organization
0.36	GO:0006936	muscle contraction

0.70	GO:0005509	calcium ion binding
0.47	GO:0035254	glutamate receptor binding
0.45	GO:0032036	myosin heavy chain binding
0.36	GO:0008307	structural constituent of muscle
0.35	GO:0045159	myosin II binding
0.35	GO:0030898	actin-dependent ATPase activity
0.34	GO:0051015	actin filament binding
0.34	GO:0019904	protein domain specific binding
0.34	GO:0046982	protein heterodimerization activity
0.33	GO:0051020	GTPase binding

0.52	GO:0016460	myosin II complex
0.51	GO:0097517	contractile actin filament bundle
0.51	GO:0042641	actomyosin
0.50	GO:0030018	Z disc
0.38	GO:0099738	cell cortex region
0.35	GO:0097513	myosin II filament
0.34	GO:0005829	cytosol
0.34	GO:0005903	brush border
0.34	GO:0070062	extracellular exosome
0.34	GO:0045177	apical part of cell

sp|P24855|DNAS1_HUMAN
Deoxyribonuclease-1
Search

DNASE1

0.63	Deoxyribonuclease

0.76	GO:0006308	DNA catabolic process
0.62	GO:0070948	regulation of neutrophil mediated cytotoxicity
0.59	GO:0002283	neutrophil activation involved in immune response
0.59	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.58	GO:0002673	regulation of acute inflammatory response
0.50	GO:0003335	corneocyte development
0.47	GO:0001942	hair follicle development
0.44	GO:0006915	apoptotic process
0.34	GO:0010623	programmed cell death involved in cell development
0.33	GO:0022411	cellular component disassembly

0.71	GO:0004536	deoxyribonuclease activity
0.61	GO:0004519	endonuclease activity
0.42	GO:0003779	actin binding
0.33	GO:0005509	calcium ion binding
0.32	GO:0003677	DNA binding

0.43	GO:0005634	nucleus
0.41	GO:0005576	extracellular region
0.41	GO:0012505	endomembrane system
0.39	GO:0031967	organelle envelope
0.36	GO:0031982	vesicle
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|P24863|CCNC_HUMAN
Cyclin-C
Search

CCNC

0.90

Cyclin C

0.76	GO:0045859	regulation of protein kinase activity
0.49	GO:1901409	positive regulation of phosphorylation of RNA polymerase II C-terminal domain
0.47	GO:0072015	glomerular visceral epithelial cell development
0.46	GO:0045787	positive regulation of cell cycle
0.46	GO:0033674	positive regulation of kinase activity
0.45	GO:0045944	positive regulation of transcription by RNA polymerase II
0.36	GO:0006351	transcription, DNA-templated
0.35	GO:0090209	negative regulation of triglyceride metabolic process
0.34	GO:0036211	protein modification process
0.33	GO:0016310	phosphorylation

0.82	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.34	GO:0061630	ubiquitin protein ligase activity
0.34	GO:0016301	kinase activity
0.33	GO:0005515	protein binding
0.33	GO:0016773	phosphotransferase activity, alcohol group as acceptor

0.77	GO:0016592	mediator complex
0.47	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
0.34	GO:0000151	ubiquitin ligase complex
0.30	GO:0016020	membrane

0.82

GO:0016538

sp|P24864|CCNE1_HUMAN
G1/S-specific cyclin-E1
Search

CCNE1

0.90

Cyclin E

0.82	GO:0000082	G1/S transition of mitotic cell cycle
0.72	GO:0051726	regulation of cell cycle
0.57	GO:0007129	synapsis
0.54	GO:0000723	telomere maintenance
0.53	GO:0000122	negative regulation of transcription by RNA polymerase II
0.53	GO:0016055	Wnt signaling pathway
0.52	GO:1903827	regulation of cellular protein localization
0.52	GO:0045859	regulation of protein kinase activity
0.52	GO:0006270	DNA replication initiation
0.46	GO:0006468	protein phosphorylation

0.55	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.53	GO:0019901	protein kinase binding
0.45	GO:0016301	kinase activity
0.36	GO:0050681	androgen receptor binding
0.35	GO:0003713	transcription coactivator activity
0.34	GO:0032403	protein complex binding

0.61	GO:0005634	nucleus
0.61	GO:0097134	cyclin E1-CDK2 complex
0.48	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.34	GO:0097135	cyclin E2-CDK2 complex
0.34	GO:0005829	cytosol
0.34	GO:0015630	microtubule cytoskeleton

0.55

GO:0016538

sp|P24903|CP2F1_HUMAN
Cytochrome P450 2F1
Search

CYP2F1

0.86	Cytochrome P450 family 2 subfamily F member 1

0.56	GO:0019373	epoxygenase P450 pathway
0.54	GO:0090420	naphthalene-containing compound metabolic process
0.53	GO:0055114	oxidation-reduction process
0.43	GO:0009636	response to toxic substance
0.41	GO:0017144	drug metabolic process
0.41	GO:0042196	chlorinated hydrocarbon metabolic process
0.37	GO:0007565	female pregnancy
0.36	GO:0006587	serotonin biosynthetic process from tryptophan
0.35	GO:0042423	catecholamine biosynthetic process
0.35	GO:0007608	sensory perception of smell

0.69	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.58	GO:0019825	oxygen binding
0.57	GO:0008391	arachidonic acid monooxygenase activity
0.56	GO:0008395	steroid hydroxylase activity
0.34	GO:0005515	protein binding
0.33	GO:0008519	ammonium transmembrane transporter activity

0.42	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0031090	organelle membrane
0.32	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0016712

sp|P24928|RPB1_HUMAN
DNA-directed RNA polymerase II subunit RPB1
Search

POLR2A

0.49	DNA-directed RNA polymerase subunit

0.72	GO:0006366	transcription by RNA polymerase II
0.36	GO:0033120	positive regulation of RNA splicing
0.36	GO:0071453	cellular response to oxygen levels
0.35	GO:0014070	response to organic cyclic compound
0.35	GO:0006353	DNA-templated transcription, termination

0.69	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.54	GO:0003677	DNA binding
0.50	GO:0001067	regulatory region nucleic acid binding
0.35	GO:0031625	ubiquitin protein ligase binding
0.33	GO:0003723	RNA binding
0.33	GO:0046872	metal ion binding

0.77	GO:0005665	DNA-directed RNA polymerase II, core complex
0.54	GO:0005719	nuclear euchromatin
0.36	GO:0000974	Prp19 complex
0.35	GO:0005730	nucleolus

0.69

GO:0003899

sp|P24941|CDK2_HUMAN
Cyclin-dependent kinase 2
Search

CDK2

0.91	Porcine cyclin dependent kinase 2

0.62	GO:0006468	protein phosphorylation
0.54	GO:0000082	G1/S transition of mitotic cell cycle
0.54	GO:0032298	positive regulation of DNA-dependent DNA replication initiation
0.53	GO:0008284	positive regulation of cell proliferation
0.52	GO:0051726	regulation of cell cycle
0.52	GO:0007099	centriole replication
0.51	GO:0007265	Ras protein signal transduction
0.50	GO:0060968	regulation of gene silencing
0.50	GO:0018209	peptidyl-serine modification
0.48	GO:0000122	negative regulation of transcription by RNA polymerase II

0.67	GO:0004674	protein serine/threonine kinase activity
0.58	GO:0097472	cyclin-dependent protein kinase activity
0.54	GO:0030332	cyclin binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0035173	histone kinase activity
0.48	GO:0019904	protein domain specific binding
0.35	GO:0046872	metal ion binding

0.56	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
0.55	GO:0000806	Y chromosome
0.53	GO:0000805	X chromosome
0.53	GO:0015030	Cajal body
0.49	GO:0005815	microtubule organizing center
0.49	GO:0000781	chromosome, telomeric region
0.49	GO:0005768	endosome
0.48	GO:0005667	transcription factor complex
0.48	GO:0000793	condensed chromosome
0.35	GO:0005829	cytosol

0.67

GO:0004674

sp|P25021|HRH2_HUMAN
Histamine H2 receptor
Search

HRH2

0.97	Histamine receptor H2

0.83	GO:0001696	gastric acid secretion
0.81	GO:0045907	positive regulation of vasoconstriction
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.54	GO:0008542	visual learning
0.54	GO:0003382	epithelial cell morphogenesis
0.53	GO:0007613	memory
0.52	GO:0048167	regulation of synaptic plasticity
0.52	GO:0048565	digestive tract development
0.51	GO:0048732	gland development
0.51	GO:1901998	toxin transport

0.81	GO:0004969	histamine receptor activity
0.44	GO:0004952	dopamine neurotransmitter receptor activity
0.38	GO:0099589	serotonin receptor activity
0.36	GO:0001594	trace-amine receptor activity
0.35	GO:0051378	serotonin binding
0.35	GO:0004935	adrenergic receptor activity
0.34	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.33	GO:0009881	photoreceptor activity
0.33	GO:0004989	octopamine receptor activity

0.41

GO:0005887

integral component of plasma membrane

0.34

GO:0004715

sp|P25024|CXCR1_HUMAN
C-X-C chemokine receptor type 1
Search

0.97	High affinity interleukin-8 receptor B

0.83	GO:0070098	chemokine-mediated signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.71	GO:0006935	chemotaxis
0.57	GO:0038112	interleukin-8-mediated signaling pathway
0.53	GO:0031623	receptor internalization
0.48	GO:0042119	neutrophil activation
0.48	GO:0006968	cellular defense response
0.47	GO:1990266	neutrophil migration
0.44	GO:0008284	positive regulation of cell proliferation
0.43	GO:0043066	negative regulation of apoptotic process

0.86	GO:0016494	C-X-C chemokine receptor activity
0.80	GO:0019959	interleukin-8 binding
0.39	GO:0016493	C-C chemokine receptor activity
0.37	GO:0051916	granulocyte colony-stimulating factor binding
0.34	GO:0005044	scavenger receptor activity
0.34	GO:0035716	chemokine (C-C motif) ligand 12 binding
0.34	GO:0035715	chemokine (C-C motif) ligand 2 binding
0.34	GO:0035717	chemokine (C-C motif) ligand 7 binding
0.34	GO:0031727	CCR2 chemokine receptor binding
0.33	GO:0008289	lipid binding

0.47	GO:0042629	mast cell granule
0.43	GO:0009986	cell surface
0.39	GO:0005886	plasma membrane
0.37	GO:0030667	secretory granule membrane
0.33	GO:0005576	extracellular region
0.33	GO:0098552	side of membrane
0.30	GO:0016021	integral component of membrane

sp|P25025|CXCR2_HUMAN
C-X-C chemokine receptor type 2
Search

0.97	High affinity interleukin-8 receptor B

0.84	GO:0070098	chemokine-mediated signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.71	GO:0006935	chemotaxis
0.57	GO:0038112	interleukin-8-mediated signaling pathway
0.53	GO:0031623	receptor internalization
0.49	GO:0042119	neutrophil activation
0.49	GO:0006968	cellular defense response
0.48	GO:1990266	neutrophil migration
0.46	GO:0008284	positive regulation of cell proliferation
0.44	GO:0043066	negative regulation of apoptotic process

0.86	GO:0016494	C-X-C chemokine receptor activity
0.80	GO:0019959	interleukin-8 binding
0.39	GO:0016493	C-C chemokine receptor activity
0.38	GO:0051916	granulocyte colony-stimulating factor binding
0.34	GO:0035716	chemokine (C-C motif) ligand 12 binding
0.34	GO:0035715	chemokine (C-C motif) ligand 2 binding
0.34	GO:0035717	chemokine (C-C motif) ligand 7 binding
0.34	GO:0031727	CCR2 chemokine receptor binding
0.33	GO:0008289	lipid binding

0.48	GO:0042629	mast cell granule
0.44	GO:0009986	cell surface
0.39	GO:0005886	plasma membrane
0.37	GO:0030667	secretory granule membrane
0.33	GO:0005576	extracellular region
0.33	GO:0098552	side of membrane
0.30	GO:0016021	integral component of membrane

sp|P25054|APC_HUMAN
Adenomatous polyposis coli protein
Search

APC

0.72	Adenomatous polyposis coli

0.85	GO:0007026	negative regulation of microtubule depolymerization
0.84	GO:0007050	cell cycle arrest
0.83	GO:0030178	negative regulation of Wnt signaling pathway
0.81	GO:0000281	mitotic cytokinesis
0.79	GO:0008285	negative regulation of cell proliferation
0.79	GO:0043065	positive regulation of apoptotic process
0.78	GO:0016477	cell migration
0.76	GO:0016055	Wnt signaling pathway
0.65	GO:0006974	cellular response to DNA damage stimulus
0.51	GO:0061380	superior colliculus development

0.84	GO:0008013	beta-catenin binding
0.71	GO:0008017	microtubule binding
0.38	GO:0045295	gamma-catenin binding
0.37	GO:0070840	dynein complex binding
0.37	GO:0019887	protein kinase regulator activity
0.36	GO:0031625	ubiquitin protein ligase binding
0.36	GO:0019901	protein kinase binding
0.36	GO:0042802	identical protein binding
0.33	GO:0002020	protease binding
0.32	GO:0045296	cadherin binding

0.61	GO:0005634	nucleus
0.49	GO:0005737	cytoplasm
0.38	GO:0016342	catenin complex
0.37	GO:0016328	lateral plasma membrane
0.37	GO:0032587	ruffle membrane
0.37	GO:0005913	cell-cell adherens junction
0.37	GO:0030027	lamellipodium
0.37	GO:0005923	bicellular tight junction
0.36	GO:0000776	kinetochore
0.36	GO:0005813	centrosome

sp|P25063|CD24_HUMAN
Signal transducer CD24
Search

CD24

0.97	Signal transducer CD24

0.72	GO:0007155	cell adhesion
0.61	GO:0032595	B cell receptor transport within lipid bilayer
0.61	GO:0032913	negative regulation of transforming growth factor beta3 production
0.59	GO:0072139	glomerular parietal epithelial cell differentiation
0.59	GO:2000768	positive regulation of nephron tubule epithelial cell differentiation
0.59	GO:0032596	protein transport into membrane raft
0.58	GO:0032599	protein transport out of membrane raft
0.58	GO:0033606	chemokine receptor transport within lipid bilayer
0.57	GO:0042104	positive regulation of activated T cell proliferation
0.57	GO:0031295	T cell costimulation

0.57	GO:0030296	protein tyrosine kinase activator activity
0.52	GO:0019901	protein kinase binding
0.49	GO:0051879	Hsp90 protein binding
0.49	GO:0030544	Hsp70 protein binding
0.43	GO:0030246	carbohydrate binding
0.38	GO:0004871	signal transducer activity

0.54	GO:0031362	anchored component of external side of plasma membrane
0.53	GO:0045121	membrane raft
0.50	GO:0031528	microvillus membrane
0.49	GO:0060170	ciliary membrane
0.45	GO:0045202	synapse
0.41	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

sp|P25067|CO8A2_HUMAN
Collagen alpha-2(VIII) chain
Search

COL8A1

0.90	Collagen type VIII alpha 1 chain

0.59	GO:0050673	epithelial cell proliferation
0.59	GO:0048593	camera-type eye morphogenesis
0.52	GO:0035987	endodermal cell differentiation
0.50	GO:0010811	positive regulation of cell-substrate adhesion
0.40	GO:0001525	angiogenesis
0.39	GO:0007155	cell adhesion
0.37	GO:0030574	collagen catabolic process
0.36	GO:0030198	extracellular matrix organization

0.34	GO:0005201	extracellular matrix structural constituent
0.34	GO:0030674	protein binding, bridging

0.77	GO:0005581	collagen trimer
0.65	GO:0005576	extracellular region
0.41	GO:0005938	cell cortex
0.36	GO:0005788	endoplasmic reticulum lumen
0.35	GO:0031982	vesicle
0.34	GO:0043235	receptor complex
0.34	GO:0099081	supramolecular polymer
0.30	GO:0031224	intrinsic component of membrane

sp|P25089|FPR3_HUMAN
N-formyl peptide receptor 3
Search

0.96	Formyl peptide receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.55	GO:0002430	complement receptor mediated signaling pathway
0.52	GO:0050900	leukocyte migration
0.52	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.51	GO:0060326	cell chemotaxis
0.51	GO:0006954	inflammatory response
0.49	GO:1904646	cellular response to amyloid-beta
0.49	GO:0090026	positive regulation of monocyte chemotaxis
0.47	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.47	GO:0019722	calcium-mediated signaling

0.85	GO:0004982	N-formyl peptide receptor activity
0.55	GO:0004875	complement receptor activity
0.52	GO:0005124	scavenger receptor binding
0.38	GO:0050786	RAGE receptor binding
0.36	GO:0038024	cargo receptor activity
0.33	GO:0004945	angiotensin type II receptor activity
0.32	GO:0019956	chemokine binding
0.32	GO:0004950	chemokine receptor activity

0.45	GO:0005887	integral component of plasma membrane
0.37	GO:0101003	ficolin-1-rich granule membrane
0.36	GO:0035579	specific granule membrane
0.36	GO:0070821	tertiary granule membrane
0.35	GO:0035577	azurophil granule membrane
0.34	GO:0060417	yolk
0.32	GO:0005829	cytosol

sp|P25090|FPR2_HUMAN
N-formyl peptide receptor 2
Search

0.96	Formyl peptide receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.57	GO:0002430	complement receptor mediated signaling pathway
0.53	GO:0050900	leukocyte migration
0.53	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.53	GO:0060326	cell chemotaxis
0.52	GO:0006954	inflammatory response
0.50	GO:1904646	cellular response to amyloid-beta
0.50	GO:0090026	positive regulation of monocyte chemotaxis
0.48	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.48	GO:0019722	calcium-mediated signaling

0.85	GO:0004982	N-formyl peptide receptor activity
0.57	GO:0004875	complement receptor activity
0.53	GO:0005124	scavenger receptor binding
0.38	GO:0050786	RAGE receptor binding
0.37	GO:0038024	cargo receptor activity

0.46	GO:0005887	integral component of plasma membrane
0.38	GO:0101003	ficolin-1-rich granule membrane
0.36	GO:0035579	specific granule membrane
0.36	GO:0070821	tertiary granule membrane
0.35	GO:0035577	azurophil granule membrane

sp|P25092|GUC2C_HUMAN
Heat-stable enterotoxin receptor
Search

GUCY2C

0.57	Heat-stable enterotoxin receptor

0.77	GO:0006182	cGMP biosynthetic process
0.62	GO:0042127	regulation of cell proliferation
0.61	GO:0035556	intracellular signal transduction
0.59	GO:0006468	protein phosphorylation
0.56	GO:0007168	receptor guanylyl cyclase signaling pathway
0.56	GO:0009636	response to toxic substance
0.53	GO:0007586	digestion

0.78	GO:0004383	guanylate cyclase activity
0.69	GO:0004016	adenylate cyclase activity
0.66	GO:0015643	toxic substance binding
0.61	GO:0032550	purine ribonucleoside binding
0.61	GO:0019001	guanyl nucleotide binding
0.60	GO:0004672	protein kinase activity
0.52	GO:0032559	adenyl ribonucleotide binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0005515	protein binding

0.75	GO:0008074	guanylate cyclase complex, soluble
0.67	GO:0005789	endoplasmic reticulum membrane
0.52	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.78

GO:0004383

sp|P25098|ARBK1_HUMAN
Beta-adrenergic receptor kinase 1
Search

0.69	G protein-coupled receptor kinase

0.63	GO:0006468	protein phosphorylation
0.61	GO:0007165	signal transduction
0.59	GO:0031623	receptor internalization
0.57	GO:0003108	negative regulation of the force of heart contraction by chemical signal
0.55	GO:0045988	negative regulation of striated muscle contraction
0.55	GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
0.53	GO:0060048	cardiac muscle contraction
0.52	GO:0007507	heart development
0.52	GO:0018210	peptidyl-threonine modification
0.51	GO:0018209	peptidyl-serine modification

0.85	GO:0004703	G-protein coupled receptor kinase activity
0.57	GO:0031755	Edg-2 lysophosphatidic acid receptor binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0047696	beta-adrenergic receptor kinase activity
0.37	GO:0031694	alpha-2A adrenergic receptor binding
0.34	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.34	GO:0004725	protein tyrosine phosphatase activity

0.38	GO:0005737	cytoplasm
0.36	GO:0120025	plasma membrane bounded cell projection
0.36	GO:0005886	plasma membrane
0.34	GO:0045121	membrane raft
0.34	GO:0045177	apical part of cell
0.34	GO:0036477	somatodendritic compartment
0.34	GO:0098794	postsynapse
0.34	GO:0044463	cell projection part
0.33	GO:0043226	organelle

0.85

EC:2.7.11.16

GO:0004703

sp|P25100|ADA1D_HUMAN
Alpha-1D adrenergic receptor
Search

ADRA1D

0.85	Adrenoceptor alpha 1D

0.85	GO:0071875	adrenergic receptor signaling pathway
0.66	GO:0019229	regulation of vasoconstriction
0.64	GO:0006937	regulation of muscle contraction
0.60	GO:0008016	regulation of heart contraction
0.59	GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
0.55	GO:1903524	positive regulation of blood circulation
0.55	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
0.53	GO:0043410	positive regulation of MAPK cascade
0.50	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.50	GO:0007204	positive regulation of cytosolic calcium ion concentration

0.86	GO:0004937	alpha1-adrenergic receptor activity
0.50	GO:0046982	protein heterodimerization activity

0.55	GO:0005886	plasma membrane
0.53	GO:0031965	nuclear membrane
0.39	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|P25101|EDNRA_HUMAN
Endothelin-1 receptor
Search

EDNRA

0.97	Endothelin receptor type A

0.86	GO:0086100	endothelin receptor signaling pathway
0.85	GO:0048484	enteric nervous system development
0.85	GO:0042310	vasoconstriction
0.83	GO:0008217	regulation of blood pressure
0.61	GO:0014820	tonic smooth muscle contraction
0.58	GO:0001569	branching involved in blood vessel morphogenesis
0.58	GO:0007585	respiratory gaseous exchange
0.57	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.57	GO:0014032	neural crest cell development
0.56	GO:0015758	glucose transport

0.86	GO:0004962	endothelin receptor activity
0.35	GO:0004435	phosphatidylinositol phospholipase C activity
0.34	GO:0005515	protein binding
0.34	GO:0004713	protein tyrosine kinase activity
0.33	GO:0003924	GTPase activity
0.33	GO:0005525	GTP binding
0.32	GO:0003735	structural constituent of ribosome

0.36	GO:0005886	plasma membrane
0.34	GO:0098857	membrane microdomain
0.34	GO:0031965	nuclear membrane
0.32	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

0.35	EC:3.1.4.11	GO:0004435
0.35	KEGG:R03435	GO:0004435

sp|P25103|NK1R_HUMAN
Substance-P receptor
Search

TACR1

0.97	Neuromedin-K receptor

0.85	GO:0007217	tachykinin receptor signaling pathway
0.60	GO:1902093	positive regulation of flagellated sperm motility
0.56	GO:0070472	regulation of uterine smooth muscle contraction
0.54	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.54	GO:0048265	response to pain
0.48	GO:0045987	positive regulation of smooth muscle contraction
0.44	GO:0007268	chemical synaptic transmission
0.42	GO:0072347	response to anesthetic
0.42	GO:0043279	response to alkaloid
0.41	GO:0060359	response to ammonium ion

0.86	GO:0004995	tachykinin receptor activity
0.34	GO:0050254	rhodopsin kinase activity
0.33	GO:0005515	protein binding

0.59	GO:0097225	sperm midpiece
0.58	GO:0061827	sperm head
0.56	GO:0005886	plasma membrane
0.38	GO:0030425	dendrite
0.38	GO:0044297	cell body
0.37	GO:0009986	cell surface
0.33	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.34

EC:2.7.11.14

GO:0050254

sp|P25105|PTAFR_HUMAN
Platelet-activating factor receptor
Search

PTAFR

0.97	Platelet-activating factor receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.70	GO:0006935	chemotaxis
0.64	GO:0032959	inositol trisphosphate biosynthetic process
0.59	GO:0031663	lipopolysaccharide-mediated signaling pathway
0.59	GO:0001816	cytokine production
0.58	GO:0006954	inflammatory response
0.57	GO:0048015	phosphatidylinositol-mediated signaling
0.50	GO:0035590	purinergic nucleotide receptor signaling pathway
0.43	GO:0002687	positive regulation of leukocyte migration
0.42	GO:0019221	cytokine-mediated signaling pathway

0.86	GO:0004992	platelet activating factor receptor activity
0.60	GO:0001875	lipopolysaccharide receptor activity
0.58	GO:0001530	lipopolysaccharide binding
0.54	GO:0005543	phospholipid binding
0.51	GO:0001608	G-protein coupled nucleotide receptor activity
0.50	GO:0001614	purinergic nucleotide receptor activity
0.42	GO:0004950	chemokine receptor activity
0.40	GO:0051019	mitogen-activated protein kinase binding
0.37	GO:0019956	chemokine binding
0.37	GO:0031727	CCR2 chemokine receptor binding

0.43	GO:0005887	integral component of plasma membrane
0.38	GO:0005622	intracellular
0.35	GO:0009897	external side of plasma membrane
0.35	GO:0012506	vesicle membrane
0.34	GO:0098805	whole membrane
0.34	GO:0098588	bounding membrane of organelle
0.34	GO:0012505	endomembrane system
0.32	GO:0043204	perikaryon
0.32	GO:0030425	dendrite
0.32	GO:0043234	protein complex

0.32

GO:0004725

sp|P25106|ACKR3_HUMAN
Atypical chemokine receptor 3
Search

ACKR3

0.97	C-X-C chemokine receptor type 7

0.84	GO:0001570	vasculogenesis
0.79	GO:0001525	angiogenesis
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.70	GO:0006935	chemotaxis
0.60	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
0.59	GO:0031623	receptor internalization
0.59	GO:0070098	chemokine-mediated signaling pathway
0.58	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.46	GO:0048920	posterior lateral line neuromast primordium migration
0.41	GO:1905322	positive regulation of mesenchymal stem cell migration

0.85	GO:0019956	chemokine binding
0.84	GO:0015026	coreceptor activity
0.72	GO:0004930	G-protein coupled receptor activity
0.58	GO:0004896	cytokine receptor activity
0.56	GO:0005044	scavenger receptor activity
0.56	GO:0001653	peptide receptor activity
0.35	GO:0016502	nucleotide receptor activity
0.35	GO:0035586	purinergic receptor activity
0.34	GO:0008289	lipid binding
0.33	GO:0004876	complement component C3a receptor activity

0.56	GO:0005905	clathrin-coated pit
0.54	GO:0005768	endosome
0.54	GO:0009986	cell surface
0.44	GO:0005886	plasma membrane
0.43	GO:0043231	intracellular membrane-bounded organelle
0.39	GO:0048471	perinuclear region of cytoplasm
0.32	GO:0043005	neuron projection
0.32	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

sp|P25116|PAR1_HUMAN
Proteinase-activated receptor 1
Search

F2R

0.97	Coagulation factor II thrombin receptor

0.85	GO:0070493	thrombin-activated receptor signaling pathway
0.82	GO:0007596	blood coagulation
0.68	GO:1900133	regulation of renin secretion into blood stream
0.67	GO:0035025	positive regulation of Rho protein signal transduction
0.65	GO:2000484	positive regulation of interleukin-8 secretion
0.64	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
0.64	GO:1903524	positive regulation of blood circulation
0.64	GO:2000778	positive regulation of interleukin-6 secretion
0.64	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.63	GO:0030193	regulation of blood coagulation

0.86	GO:0015057	thrombin-activated receptor activity
0.67	GO:0031681	G-protein beta-subunit binding
0.65	GO:0001965	G-protein alpha-subunit binding
0.51	GO:0005102	receptor binding
0.37	GO:0032795	heterotrimeric G-protein binding
0.33	GO:0008233	peptidase activity
0.32	GO:0004983	neuropeptide Y receptor activity

0.62	GO:0031094	platelet dense tubular network
0.58	GO:0005901	caveola
0.57	GO:0005769	early endosome
0.54	GO:0005770	late endosome
0.52	GO:0009986	cell surface
0.50	GO:0031594	neuromuscular junction
0.48	GO:0045211	postsynaptic membrane
0.46	GO:0031143	pseudopodium
0.45	GO:0005887	integral component of plasma membrane
0.35	GO:0005794	Golgi apparatus

0.33

GO:0008233

sp|P25189|MYP0_HUMAN
Myelin protein P0
Search

MPZ

0.97	Myelin protein zero

0.59	GO:0098743	cell aggregation
0.57	GO:0042552	myelination
0.54	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules
0.46	GO:0023052	signaling
0.46	GO:0007154	cell communication
0.44	GO:0051716	cellular response to stimulus
0.42	GO:0065007	biological regulation
0.38	GO:0045217	cell-cell junction maintenance
0.36	GO:0060028	convergent extension involved in axis elongation

0.35	GO:0000062	fatty-acyl-CoA binding
0.34	GO:0005515	protein binding
0.34	GO:0005198	structural molecule activity

0.76	GO:0043209	myelin sheath
0.67	GO:0005887	integral component of plasma membrane
0.39	GO:0016323	basolateral plasma membrane
0.39	GO:0005791	rough endoplasmic reticulum
0.38	GO:0005764	lysosome
0.34	GO:0005925	focal adhesion
0.33	GO:0009986	cell surface

sp|P25205|MCM3_HUMAN
DNA replication licensing factor MCM3
Search

MCM3

0.49	Zygotic DNA replication licensing factor mcm3

0.75	GO:0006270	DNA replication initiation
0.52	GO:0007049	cell cycle
0.45	GO:0030174	regulation of DNA-dependent DNA replication initiation
0.40	GO:0006268	DNA unwinding involved in DNA replication

0.55	GO:0032559	adenyl ribonucleotide binding
0.55	GO:0003677	DNA binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0004386	helicase activity
0.47	GO:0003682	chromatin binding
0.40	GO:0005515	protein binding
0.36	GO:0016887	ATPase activity

0.79	GO:0042555	MCM complex
0.50	GO:0005634	nucleus
0.49	GO:0005813	centrosome
0.46	GO:0048471	perinuclear region of cytoplasm
0.45	GO:0031974	membrane-enclosed lumen
0.42	GO:0044427	chromosomal part
0.41	GO:0000428	DNA-directed RNA polymerase complex
0.40	GO:0032993	protein-DNA complex
0.30	GO:0016020	membrane

0.36

GO:0016887

sp|P25208|NFYB_HUMAN
Nuclear transcription factor Y subunit beta
Search

NFYB

0.94	Nuclear transcription factor Y subunit beta

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:1990830	cellular response to leukemia inhibitory factor
0.48	GO:1902680	positive regulation of RNA biosynthetic process
0.36	GO:0006351	transcription, DNA-templated
0.35	GO:0045540	regulation of cholesterol biosynthetic process

0.73	GO:0046982	protein heterodimerization activity
0.64	GO:0043565	sequence-specific DNA binding
0.53	GO:0070491	repressing transcription factor binding
0.52	GO:0035326	enhancer binding
0.49	GO:0001012	RNA polymerase II regulatory region DNA binding
0.47	GO:0003690	double-stranded DNA binding
0.43	GO:0003700	DNA binding transcription factor activity
0.38	GO:0032403	protein complex binding

0.60	GO:0005634	nucleus
0.48	GO:0005667	transcription factor complex
0.47	GO:0032993	protein-DNA complex
0.41	GO:0044446	intracellular organelle part
0.35	GO:0043233	organelle lumen

sp|P25311|ZA2G_HUMAN
Zinc-alpha-2-glycoprotein
Search

AZGP1

0.97	Alpha-2-glycoprotein 1, zinc-binding

0.74	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
0.62	GO:0007155	cell adhesion
0.45	GO:0019882	antigen processing and presentation
0.44	GO:0001895	retina homeostasis
0.44	GO:0006955	immune response
0.40	GO:0008285	negative regulation of cell proliferation
0.38	GO:0040014	regulation of multicellular organism growth
0.38	GO:0071806	protein transmembrane transport
0.38	GO:0090501	RNA phosphodiester bond hydrolysis
0.36	GO:0002626	negative regulation of T cell antigen processing and presentation

0.39	GO:0008320	protein transmembrane transporter activity
0.38	GO:0005515	protein binding
0.38	GO:0004540	ribonuclease activity
0.36	GO:0042605	peptide antigen binding

0.64	GO:0005615	extracellular space
0.64	GO:0031012	extracellular matrix
0.47	GO:0005886	plasma membrane
0.43	GO:1903561	extracellular vesicle
0.38	GO:0098796	membrane protein complex
0.38	GO:0005634	nucleus
0.35	GO:0043235	receptor complex
0.30	GO:0016021	integral component of membrane

sp|P25325|THTM_HUMAN
3-mercaptopyruvate sulfurtransferase
Search

MPST

0.52	Mercaptopyruvate sulfurtransferase

0.40	GO:0035928	rRNA import into mitochondrion
0.39	GO:0019346	transsulfuration
0.38	GO:0048856	anatomical structure development
0.37	GO:0070813	hydrogen sulfide metabolic process
0.37	GO:0009403	toxin biosynthetic process
0.36	GO:0030154	cell differentiation
0.36	GO:0009440	cyanate catabolic process
0.36	GO:0032501	multicellular organismal process
0.35	GO:0044272	sulfur compound biosynthetic process
0.34	GO:0042221	response to chemical

0.78	GO:0004792	thiosulfate sulfurtransferase activity
0.38	GO:0016784	3-mercaptopyruvate sulfurtransferase activity
0.38	GO:0008097	5S rRNA binding
0.36	GO:0042802	identical protein binding
0.34	GO:0004896	cytokine receptor activity
0.33	GO:0004252	serine-type endopeptidase activity

0.37	GO:0005739	mitochondrion
0.37	GO:0043005	neuron projection
0.37	GO:0045202	synapse
0.37	GO:0030054	cell junction
0.36	GO:0070062	extracellular exosome
0.36	GO:0019866	organelle inner membrane
0.36	GO:0005829	cytosol
0.33	GO:0031974	membrane-enclosed lumen
0.30	GO:0031224	intrinsic component of membrane

0.78	EC:2.8.1.1	GO:0004792
0.78	KEGG:R01931	GO:0004792

sp|P25391|LAMA1_HUMAN
Laminin subunit alpha-1
Search

LAMA2

0.58	Laminin subunit alpha 1

0.82	GO:0045995	regulation of embryonic development
0.78	GO:0030334	regulation of cell migration
0.75	GO:0030155	regulation of cell adhesion
0.70	GO:0007155	cell adhesion
0.64	GO:0003412	establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis
0.61	GO:0060035	notochord cell development
0.61	GO:0061303	cornea development in camera-type eye
0.60	GO:0007634	optokinetic behavior
0.59	GO:0031290	retinal ganglion cell axon guidance
0.58	GO:0048854	brain morphogenesis

0.72	GO:0005102	receptor binding
0.44	GO:0008022	protein C-terminus binding
0.32	GO:0005198	structural molecule activity

0.50	GO:0005605	basal lamina
0.45	GO:0005615	extracellular space
0.42	GO:0042383	sarcolemma
0.38	GO:0043234	protein complex
0.34	GO:0043197	dendritic spine
0.34	GO:1903561	extracellular vesicle
0.30	GO:0016021	integral component of membrane

sp|P25398|RS12_HUMAN
40S ribosomal protein S12
Search

RPS12

0.68	40S ribosomal protein S12

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.52	GO:0009059	macromolecule biosynthetic process
0.34	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0010243	response to organonitrogen compound
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.34	GO:0019083	viral transcription
0.33	GO:0016072	rRNA metabolic process
0.33	GO:0042254	ribosome biogenesis

0.64	GO:0003735	structural constituent of ribosome
0.33	GO:0003723	RNA binding

0.61	GO:0005840	ribosome
0.48	GO:0044445	cytosolic part
0.43	GO:0005794	Golgi apparatus
0.42	GO:0044446	intracellular organelle part
0.33	GO:0043233	organelle lumen
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|P25440|BRD2_HUMAN
Bromodomain-containing protein 2
Search

BRD2

0.81	Bromodomain-containing protein 3 isoform B

sp|P25445|TNR6_HUMAN
Tumor necrosis factor receptor superfamily member 6
Search

FAS

0.94	Fas cell surface death receptor

0.78	GO:0006915	apoptotic process
0.74	GO:0006955	immune response
0.61	GO:0007165	signal transduction
0.57	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
0.57	GO:0071455	cellular response to hyperoxia
0.56	GO:0070266	necroptotic process
0.55	GO:0071260	cellular response to mechanical stimulus
0.55	GO:0034198	cellular response to amino acid starvation
0.53	GO:0032872	regulation of stress-activated MAPK cascade
0.51	GO:0001934	positive regulation of protein phosphorylation

0.70	GO:0004888	transmembrane signaling receptor activity
0.52	GO:0005516	calmodulin binding
0.51	GO:0019900	kinase binding
0.50	GO:0042802	identical protein binding
0.49	GO:0043120	tumor necrosis factor binding

0.58	GO:0031265	CD95 death-inducing signaling complex
0.53	GO:0045121	membrane raft
0.51	GO:0016604	nuclear body
0.50	GO:0009986	cell surface
0.47	GO:0005829	cytosol
0.41	GO:0005887	integral component of plasma membrane
0.39	GO:0005739	mitochondrion
0.35	GO:0098552	side of membrane
0.34	GO:0005576	extracellular region

sp|P25490|TYY1_HUMAN
Transcriptional repressor protein YY1
Search

YY1

0.93	Transcriptional repressor protein YY1

0.53	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II
0.53	GO:0032688	negative regulation of interferon-beta production
0.53	GO:0010225	response to UV-C
0.51	GO:0034644	cellular response to UV
0.51	GO:0048593	camera-type eye morphogenesis
0.50	GO:0009952	anterior/posterior pattern specification
0.49	GO:0007283	spermatogenesis
0.48	GO:0000724	double-strand break repair via homologous recombination
0.47	GO:0010628	positive regulation of gene expression
0.47	GO:0006403	RNA localization

0.52	GO:0001158	enhancer sequence-specific DNA binding
0.52	GO:0000400	four-way junction DNA binding
0.51	GO:0046332	SMAD binding
0.51	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.49	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.41	GO:0003723	RNA binding
0.40	GO:0042826	histone deacetylase binding
0.36	GO:0003714	transcription corepressor activity
0.35	GO:0003713	transcription coactivator activity
0.35	GO:0003682	chromatin binding

0.50	GO:0031519	PcG protein complex
0.49	GO:0031011	Ino80 complex
0.47	GO:0005667	transcription factor complex
0.40	GO:0016363	nuclear matrix
0.36	GO:0005654	nucleoplasm
0.34	GO:0005737	cytoplasm

sp|P25685|DNJB1_HUMAN
DnaJ homolog subfamily B member 1
Search

DNAJB1

0.88	DnaJ like protein subfamily B member 1

0.69	GO:0006457	protein folding
0.55	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress
0.55	GO:0090084	negative regulation of inclusion body assembly
0.53	GO:0032781	positive regulation of ATPase activity
0.48	GO:0006986	response to unfolded protein
0.45	GO:0002088	lens development in camera-type eye
0.35	GO:1900034	regulation of cellular response to heat

0.71	GO:0051082	unfolded protein binding
0.55	GO:0051087	chaperone binding
0.54	GO:0001106	RNA polymerase II transcription corepressor activity
0.54	GO:0030544	Hsp70 protein binding
0.53	GO:0051117	ATPase binding
0.53	GO:0001671	ATPase activator activity
0.51	GO:0045296	cadherin binding

0.51	GO:0005829	cytosol
0.48	GO:0005634	nucleus
0.38	GO:0031974	membrane-enclosed lumen
0.37	GO:0070062	extracellular exosome
0.36	GO:0044446	intracellular organelle part
0.35	GO:0014069	postsynaptic density
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.34	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P25686|DNJB2_HUMAN
DnaJ homolog subfamily B member 2
Search

DNAJB2

0.87	DnaJ like protein subfamily B member 2

0.86	GO:0090084	negative regulation of inclusion body assembly
0.85	GO:1903644	regulation of chaperone-mediated protein folding
0.78	GO:0030308	negative regulation of cell growth
0.78	GO:0032091	negative regulation of protein binding
0.76	GO:0061077	chaperone-mediated protein folding
0.74	GO:0032781	positive regulation of ATPase activity
0.74	GO:0031396	regulation of protein ubiquitination
0.73	GO:0008285	negative regulation of cell proliferation
0.70	GO:0042026	protein refolding
0.52	GO:0090086	negative regulation of protein deubiquitination

0.80	GO:0030544	Hsp70 protein binding
0.75	GO:0051087	chaperone binding
0.75	GO:0001671	ATPase activator activity
0.69	GO:0051082	unfolded protein binding
0.54	GO:0044183	protein binding involved in protein folding
0.49	GO:0031593	polyubiquitin modification-dependent protein binding
0.49	GO:0070628	proteasome binding
0.47	GO:0031625	ubiquitin protein ligase binding
0.38	GO:0005200	structural constituent of cytoskeleton
0.37	GO:0003924	GTPase activity

0.72	GO:0031965	nuclear membrane
0.67	GO:0005829	cytosol
0.49	GO:0016234	inclusion body
0.47	GO:0031227	intrinsic component of endoplasmic reticulum membrane
0.45	GO:1905369	endopeptidase complex
0.40	GO:0043234	protein complex
0.37	GO:0005874	microtubule

sp|P25705|ATPA_HUMAN
ATP synthase subunit alpha, mitochondrial
Search

ATP5A1

0.45	ATP synthase subunit alpha

0.70	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.70	GO:0006754	ATP biosynthetic process
0.69	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.51	GO:0001937	negative regulation of endothelial cell proliferation
0.51	GO:0043536	positive regulation of blood vessel endothelial cell migration
0.43	GO:0006629	lipid metabolic process
0.35	GO:0042407	cristae formation
0.34	GO:0006839	mitochondrial transport
0.33	GO:0046907	intracellular transport

0.71	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
0.54	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0043532	angiostatin binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0042288	MHC class I protein binding
0.34	GO:0003723	RNA binding

0.71	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)
0.51	GO:0043209	myelin sheath
0.49	GO:0008180	COP9 signalosome
0.49	GO:0005753	mitochondrial proton-transporting ATP synthase complex
0.40	GO:0005886	plasma membrane
0.36	GO:0031012	extracellular matrix
0.36	GO:0070062	extracellular exosome
0.34	GO:0045121	membrane raft
0.34	GO:0005759	mitochondrial matrix

sp|P25713|MT3_HUMAN
Metallothionein-3
Search

0.75	Metallothionein

0.60	GO:0071248	cellular response to metal ion
0.59	GO:0045926	negative regulation of growth
0.57	GO:0097214	positive regulation of lysosomal membrane permeability
0.56	GO:0055073	cadmium ion homeostasis
0.56	GO:2000376	positive regulation of oxygen metabolic process
0.55	GO:0060547	negative regulation of necrotic cell death
0.55	GO:0010940	positive regulation of necrotic cell death
0.55	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
0.55	GO:0071732	cellular response to nitric oxide
0.54	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress

0.55	GO:0046870	cadmium ion binding
0.54	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.52	GO:0030295	protein kinase activator activity
0.49	GO:0008270	zinc ion binding
0.47	GO:0005507	copper ion binding
0.40	GO:0008144	drug binding
0.35	GO:0005515	protein binding
0.34	GO:0016209	antioxidant activity

0.57	GO:0048471	perinuclear region of cytoplasm
0.52	GO:0016234	inclusion body
0.51	GO:0008021	synaptic vesicle
0.44	GO:0005634	nucleus
0.42	GO:0097450	astrocyte end-foot
0.40	GO:0043197	dendritic spine
0.40	GO:0014069	postsynaptic density
0.40	GO:0005791	rough endoplasmic reticulum
0.39	GO:0030424	axon
0.39	GO:0005741	mitochondrial outer membrane

sp|P25774|CATS_HUMAN
Cathepsin S
Search

CTSS

0.89	LOW QUALITY PROTEIN: cathepsin S

0.61	GO:0006508	proteolysis
0.61	GO:0034769	basement membrane disassembly
0.60	GO:0030574	collagen catabolic process
0.57	GO:0097067	cellular response to thyroid hormone stimulus
0.56	GO:2001259	positive regulation of cation channel activity
0.56	GO:0010447	response to acidic pH
0.54	GO:0002250	adaptive immune response
0.54	GO:0048002	antigen processing and presentation of peptide antigen
0.53	GO:0044257	cellular protein catabolic process
0.49	GO:0051604	protein maturation

0.72	GO:0008234	cysteine-type peptidase activity
0.61	GO:0001968	fibronectin binding
0.60	GO:0043394	proteoglycan binding
0.58	GO:0005518	collagen binding
0.57	GO:0043236	laminin binding
0.49	GO:0004175	endopeptidase activity
0.35	GO:0017171	serine hydrolase activity
0.34	GO:0070273	phosphatidylinositol-4-phosphate binding
0.33	GO:0046983	protein dimerization activity
0.33	GO:0003700	DNA binding transcription factor activity

0.56	GO:0005764	lysosome
0.54	GO:0005615	extracellular space
0.40	GO:0043233	organelle lumen
0.39	GO:0044428	nuclear part
0.36	GO:0044440	endosomal part
0.36	GO:0101002	ficolin-1-rich granule
0.36	GO:0070820	tertiary granule
0.34	GO:0044437	vacuolar part
0.34	GO:0005769	early endosome
0.34	GO:0005667	transcription factor complex

0.72

GO:0008234

sp|P25786|PSA1_HUMAN
Proteasome subunit alpha type-1
Search

PSMA1

0.49	Proteasome endopeptidase complex

0.71	GO:0051603	proteolysis involved in cellular protein catabolic process
0.70	GO:0043632	modification-dependent macromolecule catabolic process
0.54	GO:0002862	negative regulation of inflammatory response to antigenic stimulus
0.38	GO:0002376	immune system process
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:1902036	regulation of hematopoietic stem cell differentiation
0.35	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
0.35	GO:0070498	interleukin-1-mediated signaling pathway

0.77	GO:0070003	threonine-type peptidase activity
0.64	GO:0004175	endopeptidase activity
0.50	GO:0001530	lipopolysaccharide binding
0.34	GO:0005515	protein binding
0.33	GO:0003723	RNA binding

0.79	GO:0019773	proteasome core complex, alpha-subunit complex
0.59	GO:0005634	nucleus
0.49	GO:0005737	cytoplasm
0.44	GO:0005813	centrosome
0.41	GO:0043233	organelle lumen
0.36	GO:0070062	extracellular exosome
0.34	GO:0005844	polysome
0.30	GO:0044425	membrane part

sp|P25787|PSA2_HUMAN
Proteasome subunit alpha type-2
Search

PSMA2

0.48	Proteasome endopeptidase complex

0.72	GO:0051603	proteolysis involved in cellular protein catabolic process
0.67	GO:0043632	modification-dependent macromolecule catabolic process
0.35	GO:0009615	response to virus
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.35	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:1902036	regulation of hematopoietic stem cell differentiation
0.35	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia

0.77	GO:0004298	threonine-type endopeptidase activity
0.34	GO:0001104	RNA polymerase II transcription cofactor activity
0.33	GO:0005515	protein binding

0.79	GO:0019773	proteasome core complex, alpha-subunit complex
0.57	GO:0005634	nucleus
0.51	GO:0000932	P-body
0.38	GO:0070062	extracellular exosome
0.35	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0034774	secretory granule lumen
0.34	GO:0005829	cytosol
0.30	GO:0044425	membrane part

0.77

GO:0004298

sp|P25788|PSA3_HUMAN
Proteasome subunit alpha type-3
Search

PSMA3

0.48	Proteasome endopeptidase complex

0.72	GO:0051603	proteolysis involved in cellular protein catabolic process
0.71	GO:0043632	modification-dependent macromolecule catabolic process
0.49	GO:0052548	regulation of endopeptidase activity
0.36	GO:0007224	smoothened signaling pathway
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.35	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:1902036	regulation of hematopoietic stem cell differentiation

0.77	GO:0070003	threonine-type peptidase activity
0.64	GO:0004175	endopeptidase activity
0.34	GO:0005515	protein binding
0.34	GO:0003677	DNA binding

0.79	GO:0019773	proteasome core complex, alpha-subunit complex
0.60	GO:0005634	nucleus
0.49	GO:0005737	cytoplasm
0.38	GO:0045202	synapse
0.36	GO:0070062	extracellular exosome
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part

sp|P25789|PSA4_HUMAN
Proteasome subunit alpha type-4
Search

PSMA4

0.49	Proteasome endopeptidase complex

0.72	GO:0051603	proteolysis involved in cellular protein catabolic process
0.71	GO:0043632	modification-dependent macromolecule catabolic process
0.36	GO:0010608	posttranscriptional regulation of gene expression
0.36	GO:0032269	negative regulation of cellular protein metabolic process
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0034249	negative regulation of cellular amide metabolic process
0.35	GO:0006879	cellular iron ion homeostasis
0.35	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.35	GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway

0.77	GO:0004298	threonine-type endopeptidase activity
0.37	GO:0030350	iron-responsive element binding
0.36	GO:0030371	translation repressor activity
0.33	GO:0005515	protein binding
0.32	GO:0016301	kinase activity

0.79	GO:0019773	proteasome core complex, alpha-subunit complex
0.60	GO:0005634	nucleus
0.51	GO:0000932	P-body
0.47	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome
0.34	GO:0070013	intracellular organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.77

GO:0004298

sp|P25791|RBTN2_HUMAN
Rhombotin-2
Search

LMO2

0.91	LIM domain only 2

0.53	GO:0097067	cellular response to thyroid hormone stimulus
0.52	GO:0042789	mRNA transcription by RNA polymerase II
0.48	GO:0045944	positive regulation of transcription by RNA polymerase II
0.45	GO:0035162	embryonic hemopoiesis
0.45	GO:0061304	retinal blood vessel morphogenesis
0.44	GO:0031101	fin regeneration
0.44	GO:0001935	endothelial cell proliferation
0.43	GO:0048821	erythrocyte development
0.39	GO:0032844	regulation of homeostatic process
0.38	GO:0002682	regulation of immune system process

0.54	GO:0046872	metal ion binding
0.52	GO:0043425	bHLH transcription factor binding
0.52	GO:0070888	E-box binding
0.51	GO:0001102	RNA polymerase II activating transcription factor binding
0.51	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.49	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.40	GO:0048037	cofactor binding
0.36	GO:0003682	chromatin binding
0.32	GO:0003707	steroid hormone receptor activity

0.47	GO:0005667	transcription factor complex
0.38	GO:0005634	nucleus
0.33	GO:0043233	organelle lumen
0.32	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

sp|P25800|RBTN1_HUMAN
Rhombotin-1
Search

LMO1

0.96	LIM domain only 1

0.54	GO:0046013	regulation of T cell homeostatic proliferation
0.48	GO:0000122	negative regulation of transcription by RNA polymerase II
0.47	GO:0045944	positive regulation of transcription by RNA polymerase II
0.43	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway
0.42	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway
0.41	GO:0045600	positive regulation of fat cell differentiation
0.41	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.35	GO:1902036	regulation of hematopoietic stem cell differentiation
0.34	GO:0006351	transcription, DNA-templated

0.54	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.42	GO:0005634	nucleus
0.35	GO:0043233	organelle lumen
0.34	GO:0005737	cytoplasm
0.34	GO:0044446	intracellular organelle part
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane

sp|P25815|S100P_HUMAN
Protein S100-P
Search

S100P

0.47	Ictacalcin

0.62	GO:0043542	endothelial cell migration
0.54	GO:0010033	response to organic substance
0.51	GO:0042127	regulation of cell proliferation
0.39	GO:0006013	mannose metabolic process
0.38	GO:0006955	immune response
0.38	GO:0002446	neutrophil mediated immunity
0.38	GO:0043299	leukocyte degranulation
0.38	GO:0042119	neutrophil activation
0.36	GO:0006952	defense response
0.35	GO:0048583	regulation of response to stimulus

0.81	GO:0050786	RAGE receptor binding
0.71	GO:0048306	calcium-dependent protein binding
0.70	GO:0005509	calcium ion binding
0.59	GO:0045296	cadherin binding
0.55	GO:0042803	protein homodimerization activity
0.55	GO:0046914	transition metal ion binding
0.38	GO:0004559	alpha-mannosidase activity
0.37	GO:0030246	carbohydrate binding
0.36	GO:0035662	Toll-like receptor 4 binding
0.36	GO:0050544	arachidonic acid binding

0.57	GO:0016604	nuclear body
0.41	GO:0005737	cytoplasm
0.38	GO:0031528	microvillus membrane
0.38	GO:0031983	vesicle lumen
0.37	GO:0070062	extracellular exosome
0.36	GO:0097708	intracellular vesicle
0.35	GO:0012505	endomembrane system
0.30	GO:0031224	intrinsic component of membrane

0.38

EC:3.2.1.24

GO:0004559

sp|P25874|UCP1_HUMAN
Mitochondrial brown fat uncoupling protein 1
Search

UCP1

0.88	Mitochondrial brown fat uncoupling protein 1

0.77	GO:0006839	mitochondrial transport
0.61	GO:1990845	adaptive thermogenesis
0.57	GO:0071398	cellular response to fatty acid
0.56	GO:1903426	regulation of reactive oxygen species biosynthetic process
0.55	GO:0002021	response to dietary excess
0.54	GO:0050873	brown fat cell differentiation
0.53	GO:0009266	response to temperature stimulus
0.52	GO:0032870	cellular response to hormone stimulus
0.52	GO:0000302	response to reactive oxygen species
0.51	GO:0034599	cellular response to oxidative stress

0.64	GO:0017077	oxidative phosphorylation uncoupler activity
0.58	GO:0036041	long-chain fatty acid binding
0.48	GO:1901612	cardiolipin binding
0.41	GO:0032555	purine ribonucleotide binding
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0019001	guanyl nucleotide binding
0.33	GO:0005515	protein binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.62	GO:0031966	mitochondrial membrane
0.47	GO:0019866	organelle inner membrane
0.35	GO:0055044	symplast
0.34	GO:0005774	vacuolar membrane
0.34	GO:0005911	cell-cell junction
0.33	GO:0009507	chloroplast
0.33	GO:0005794	Golgi apparatus
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P25929|NPY1R_HUMAN
Neuropeptide Y receptor type 1
Search

NPY1R

0.97	Neuropeptide Y receptor type 1

0.78	GO:0007218	neuropeptide signaling pathway
0.58	GO:0003151	outflow tract morphogenesis
0.58	GO:0007631	feeding behavior
0.57	GO:0019233	sensory perception of pain
0.56	GO:0040014	regulation of multicellular organism growth
0.56	GO:0008015	blood circulation
0.55	GO:0007626	locomotory behavior
0.50	GO:0006006	glucose metabolic process
0.46	GO:0065008	regulation of biological quality
0.46	GO:0007268	chemical synaptic transmission

0.83	GO:0004983	neuropeptide Y receptor activity
0.42	GO:0042923	neuropeptide binding
0.34	GO:0017046	peptide hormone binding
0.33	GO:0005515	protein binding

0.37	GO:0005886	plasma membrane
0.35	GO:0008021	synaptic vesicle
0.35	GO:0030424	axon
0.34	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

sp|P25940|CO5A3_HUMAN
Collagen alpha-3(V) chain
Search

0.81	Collagen type XI alpha 2 chain

0.50	GO:0007160	cell-matrix adhesion
0.49	GO:0035989	tendon development
0.49	GO:0030199	collagen fibril organization
0.47	GO:0045112	integrin biosynthetic process
0.46	GO:1903225	negative regulation of endodermal cell differentiation
0.46	GO:0003007	heart morphogenesis
0.46	GO:0090596	sensory organ morphogenesis
0.46	GO:0032964	collagen biosynthetic process
0.46	GO:0035313	wound healing, spreading of epidermal cells
0.45	GO:0043588	skin development

0.81	GO:0005201	extracellular matrix structural constituent
0.54	GO:0008201	heparin binding
0.49	GO:0043394	proteoglycan binding
0.46	GO:0048407	platelet-derived growth factor binding
0.35	GO:0032403	protein complex binding
0.34	GO:0050840	extracellular matrix binding
0.34	GO:0050839	cell adhesion molecule binding
0.34	GO:0030674	protein binding, bridging
0.33	GO:0005102	receptor binding
0.33	GO:0046872	metal ion binding

0.71	GO:0005581	collagen trimer
0.60	GO:0098643	banded collagen fibril
0.45	GO:0005615	extracellular space
0.43	GO:0005604	basement membrane
0.38	GO:1903561	extracellular vesicle
0.37	GO:0005788	endoplasmic reticulum lumen
0.30	GO:0016020	membrane

sp|P25942|TNR5_HUMAN
Tumor necrosis factor receptor superfamily member 5
Search

CD40

0.97	Tumor necrosis factor receptor superfamily member 5

0.83	GO:0042113	B cell activation
0.71	GO:0050776	regulation of immune response
0.65	GO:0090037	positive regulation of protein kinase C signaling
0.65	GO:2000353	positive regulation of endothelial cell apoptotic process
0.64	GO:0051023	regulation of immunoglobulin secretion
0.64	GO:0042832	defense response to protozoan
0.63	GO:0032735	positive regulation of interleukin-12 production
0.63	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
0.63	GO:0043536	positive regulation of blood vessel endothelial cell migration
0.63	GO:0043491	protein kinase B signaling

0.64	GO:0004872	receptor activity
0.59	GO:0031625	ubiquitin protein ligase binding
0.44	GO:0003823	antigen binding
0.44	GO:0004871	signal transducer activity
0.42	GO:0019904	protein domain specific binding
0.34	GO:0008061	chitin binding
0.34	GO:0019955	cytokine binding

0.80	GO:0009897	external side of plasma membrane
0.64	GO:0035631	CD40 receptor complex
0.46	GO:0043196	varicosity
0.45	GO:0043231	intracellular membrane-bounded organelle
0.43	GO:0043025	neuronal cell body
0.41	GO:0005615	extracellular space
0.40	GO:1903561	extracellular vesicle
0.35	GO:0005737	cytoplasm
0.33	GO:0098857	membrane microdomain

sp|P25963|IKBA_HUMAN
NF-kappa-B inhibitor alpha
Search

NFKBIA

0.96	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

0.85	GO:0007253	cytoplasmic sequestering of NF-kappaB
0.85	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway
0.84	GO:0010745	negative regulation of macrophage derived foam cell differentiation
0.84	GO:0010875	positive regulation of cholesterol efflux
0.83	GO:0010888	negative regulation of lipid storage
0.83	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway
0.81	GO:0035994	response to muscle stretch
0.81	GO:0032495	response to muramyl dipeptide
0.80	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.80	GO:0007249	I-kappaB kinase/NF-kappaB signaling

0.83	GO:0051059	NF-kappaB binding
0.80	GO:0008139	nuclear localization sequence binding
0.74	GO:0031625	ubiquitin protein ligase binding
0.69	GO:0042802	identical protein binding
0.44	GO:0031072	heat shock protein binding
0.43	GO:0032403	protein complex binding
0.42	GO:0003700	DNA binding transcription factor activity
0.40	GO:0003677	DNA binding
0.38	GO:0001067	regulatory region nucleic acid binding
0.35	GO:0003682	chromatin binding

0.65	GO:0005829	cytosol
0.60	GO:0005634	nucleus
0.53	GO:0005886	plasma membrane
0.47	GO:0033256	I-kappaB/NF-kappaB complex
0.33	GO:0043233	organelle lumen
0.33	GO:0005739	mitochondrion
0.33	GO:0044446	intracellular organelle part
0.30	GO:0044425	membrane part

sp|P26006|ITA3_HUMAN
Integrin alpha-3
Search

ITGA3

0.96	Integrin alpha 3A subunit cytoplasmic domain variant

0.79	GO:0007229	integrin-mediated signaling pathway
0.71	GO:0007155	cell adhesion
0.63	GO:0097062	dendritic spine maintenance
0.61	GO:0097205	renal filtration
0.60	GO:0035024	negative regulation of Rho protein signal transduction
0.60	GO:0035640	exploration behavior
0.60	GO:0048333	mesodermal cell differentiation
0.60	GO:1903078	positive regulation of protein localization to plasma membrane
0.58	GO:0007613	memory
0.58	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway

0.58	GO:0002020	protease binding
0.54	GO:0046982	protein heterodimerization activity
0.44	GO:0001968	fibronectin binding
0.44	GO:0043236	laminin binding
0.43	GO:0005178	integrin binding
0.43	GO:0005518	collagen binding
0.41	GO:0019904	protein domain specific binding
0.35	GO:0046872	metal ion binding
0.32	GO:0038132	neuregulin binding
0.32	GO:0031994	insulin-like growth factor I binding

0.80	GO:0008305	integrin complex
0.62	GO:0071438	invadopodium membrane
0.61	GO:0031527	filopodium membrane
0.60	GO:0060076	excitatory synapse
0.57	GO:0016323	basolateral plasma membrane
0.57	GO:0009897	external side of plasma membrane
0.55	GO:0097060	synaptic membrane
0.43	GO:0030426	growth cone
0.42	GO:0048471	perinuclear region of cytoplasm
0.41	GO:0030054	cell junction

sp|P26010|ITB7_HUMAN
Integrin beta-7
Search

ITGB2

0.68	Integrin beta

0.82	GO:0007160	cell-matrix adhesion
0.80	GO:0007229	integrin-mediated signaling pathway
0.63	GO:0034113	heterotypic cell-cell adhesion
0.63	GO:0007159	leukocyte cell-cell adhesion
0.62	GO:0043113	receptor clustering
0.60	GO:0050900	leukocyte migration
0.54	GO:0043315	positive regulation of neutrophil degranulation
0.54	GO:0034446	substrate adhesion-dependent cell spreading
0.53	GO:0001667	ameboidal-type cell migration
0.53	GO:0032930	positive regulation of superoxide anion generation

0.65	GO:0004872	receptor activity
0.58	GO:0050839	cell adhesion molecule binding
0.48	GO:0019901	protein kinase binding
0.48	GO:0031072	heat shock protein binding
0.43	GO:0004871	signal transducer activity
0.39	GO:0001851	complement component C3b binding
0.38	GO:0001540	amyloid-beta binding
0.37	GO:0001618	virus receptor activity
0.37	GO:0046982	protein heterodimerization activity
0.36	GO:0032403	protein complex binding

0.81	GO:0008305	integrin complex
0.56	GO:0009986	cell surface
0.50	GO:0044853	plasma membrane raft
0.47	GO:0099568	cytoplasmic region
0.38	GO:0070062	extracellular exosome
0.35	GO:0101003	ficolin-1-rich granule membrane
0.35	GO:0035579	specific granule membrane
0.35	GO:0070821	tertiary granule membrane
0.35	GO:0071438	invadopodium membrane
0.34	GO:0032587	ruffle membrane

sp|P26012|ITB8_HUMAN
Integrin beta-8
Search

ITGB8

0.67	Integrin beta

0.80	GO:0007160	cell-matrix adhesion
0.79	GO:0007229	integrin-mediated signaling pathway
0.47	GO:0045766	positive regulation of angiogenesis
0.47	GO:0001573	ganglioside metabolic process
0.47	GO:0051216	cartilage development
0.43	GO:0010628	positive regulation of gene expression
0.42	GO:0001935	endothelial cell proliferation
0.42	GO:0010629	negative regulation of gene expression
0.40	GO:0001525	angiogenesis
0.36	GO:0038044	transforming growth factor-beta secretion

0.63	GO:0004872	receptor activity
0.50	GO:1990430	extracellular matrix protein binding
0.35	GO:0005178	integrin binding

0.79	GO:0008305	integrin complex
0.45	GO:0009986	cell surface
0.35	GO:0005925	focal adhesion
0.35	GO:0005813	centrosome
0.34	GO:0098552	side of membrane
0.34	GO:0005654	nucleoplasm
0.34	GO:0055120	striated muscle dense body
0.33	GO:0005605	basal lamina
0.33	GO:0031430	M band
0.33	GO:0016328	lateral plasma membrane

sp|P26022|PTX3_HUMAN
Pentraxin-related protein PTX3
Search

PTX3

0.94	Pentraxin 3, long b

0.85	GO:1903016	negative regulation of exo-alpha-sialidase activity
0.85	GO:0052403	negative regulation by host of symbiont catalytic activity
0.85	GO:0044867	modulation by host of viral catalytic activity
0.85	GO:0044870	modulation by host of viral glycoprotein metabolic process
0.85	GO:0008228	opsonization
0.85	GO:0044793	negative regulation by host of viral process
0.84	GO:0046597	negative regulation of viral entry into host cell
0.83	GO:1903019	negative regulation of glycoprotein metabolic process
0.83	GO:0001878	response to yeast
0.80	GO:0045429	positive regulation of nitric oxide biosynthetic process

0.85	GO:0001872	(1->3)-beta-D-glucan binding
0.85	GO:0046790	virion binding
0.85	GO:0001849	complement component C1q binding
0.69	GO:0042802	identical protein binding
0.40	GO:0046872	metal ion binding

0.68	GO:0005615	extracellular space
0.44	GO:1904724	tertiary granule lumen
0.44	GO:0035580	specific granule lumen

sp|P26038|MOES_HUMAN
Moesin
Search

MSN

0.97	Epididymis luminal protein 70

0.58	GO:0070489	T cell aggregation
0.57	GO:1902965	regulation of protein localization to early endosome
0.57	GO:2000643	positive regulation of early endosome to late endosome transport
0.57	GO:1905668	positive regulation of protein localization to endosome
0.56	GO:0022614	membrane to membrane docking
0.56	GO:0001771	immunological synapse formation
0.56	GO:0061028	establishment of endothelial barrier
0.56	GO:0071394	cellular response to testosterone stimulus
0.55	GO:0072678	T cell migration
0.55	GO:0045198	establishment of epithelial cell apical/basal polarity

0.73	GO:0003779	actin binding
0.52	GO:0050839	cell adhesion molecule binding
0.50	GO:0019901	protein kinase binding
0.49	GO:0003725	double-stranded RNA binding
0.48	GO:0005102	receptor binding
0.39	GO:0051117	ATPase binding
0.38	GO:0019904	protein domain specific binding
0.37	GO:0042803	protein homodimerization activity
0.35	GO:0032403	protein complex binding
0.34	GO:0044548	S100 protein binding

0.69	GO:0005856	cytoskeleton
0.56	GO:0071437	invadopodium
0.55	GO:0005902	microvillus
0.54	GO:0031143	pseudopodium
0.54	GO:0030175	filopodium
0.54	GO:0001931	uropod
0.54	GO:0016324	apical plasma membrane
0.53	GO:0005925	focal adhesion
0.52	GO:0043209	myelin sheath
0.51	GO:0016323	basolateral plasma membrane

sp|P26045|PTN3_HUMAN
Tyrosine-protein phosphatase non-receptor type 3
Search

PTPN3

0.62	Tyrosine-protein phosphatase non-receptor type

0.71	GO:0035335	peptidyl-tyrosine dephosphorylation
0.60	GO:0098902	regulation of membrane depolarization during action potential
0.59	GO:0051045	negative regulation of membrane protein ectodomain proteolysis
0.57	GO:2000649	regulation of sodium ion transmembrane transporter activity
0.53	GO:0045930	negative regulation of mitotic cell cycle
0.42	GO:0097421	liver regeneration
0.36	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway

0.71	GO:0004725	protein tyrosine phosphatase activity
0.66	GO:0008092	cytoskeletal protein binding
0.57	GO:0017080	sodium channel regulator activity
0.57	GO:0001784	phosphotyrosine residue binding
0.57	GO:0051117	ATPase binding

0.66	GO:0005856	cytoskeleton
0.52	GO:0009898	cytoplasmic side of plasma membrane
0.46	GO:0005737	cytoplasm

0.71

GO:0004725

sp|P26196|DDX6_HUMAN
Probable ATP-dependent RNA helicase DDX6
Search

DDX6

0.93	ATP-dependent RNA helicase DDX6 protein 1

0.48	GO:0033962	cytoplasmic mRNA processing body assembly
0.48	GO:0019074	viral RNA genome packaging
0.46	GO:0019827	stem cell population maintenance
0.46	GO:0045665	negative regulation of neuron differentiation
0.42	GO:0010501	RNA secondary structure unwinding
0.40	GO:0006417	regulation of translation
0.38	GO:0007283	spermatogenesis
0.37	GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
0.37	GO:0034063	stress granule assembly
0.35	GO:0009408	response to heat

0.67	GO:0004386	helicase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.45	GO:0045296	cadherin binding
0.44	GO:0019904	protein domain specific binding
0.42	GO:0008186	RNA-dependent ATPase activity
0.38	GO:0140098	catalytic activity, acting on RNA

0.49	GO:0036464	cytoplasmic ribonucleoprotein granule
0.46	GO:0016442	RISC complex
0.42	GO:0005829	cytosol
0.42	GO:0005634	nucleus
0.40	GO:0097227	sperm annulus
0.40	GO:0001520	outer dense fiber
0.39	GO:0031974	membrane-enclosed lumen
0.39	GO:0060293	germ plasm
0.39	GO:0000792	heterochromatin
0.35	GO:0005739	mitochondrion

0.35

EC:3.2.1.28

GO:0004555

sp|P26232|CTNA2_HUMAN
Catenin alpha-2
Search

CTNNA2

0.71	Catenin (cadherin-associated protein), alpha 2

0.83	GO:0048854	brain morphogenesis
0.72	GO:0007155	cell adhesion
0.66	GO:0051823	regulation of synapse structural plasticity
0.62	GO:0048813	dendrite morphogenesis
0.61	GO:0021942	radial glia guided migration of Purkinje cell
0.60	GO:0060134	prepulse inhibition
0.59	GO:0007409	axonogenesis
0.44	GO:0007010	cytoskeleton organization
0.43	GO:0045595	regulation of cell differentiation
0.42	GO:2001045	negative regulation of integrin-mediated signaling pathway

0.82	GO:0045296	cadherin binding
0.78	GO:0051015	actin filament binding
0.60	GO:0005198	structural molecule activity
0.53	GO:0042802	identical protein binding
0.44	GO:0008013	beta-catenin binding
0.41	GO:0045295	gamma-catenin binding
0.41	GO:0017166	vinculin binding
0.38	GO:0046982	protein heterodimerization activity

0.81	GO:0005913	cell-cell adherens junction
0.72	GO:0015629	actin cytoskeleton
0.59	GO:0030424	axon
0.58	GO:0030027	lamellipodium
0.56	GO:0014069	postsynaptic density
0.56	GO:0016323	basolateral plasma membrane
0.43	GO:0005634	nucleus
0.43	GO:0005829	cytosol
0.41	GO:0016600	flotillin complex
0.41	GO:0016342	catenin complex

sp|P26358|DNMT1_HUMAN
DNA (cytosine-5)-methyltransferase 1
Search

DNMT1

0.74	DNA (cytosine-5)-methyltransferase

0.76	GO:0090116	C-5 methylation of cytosine
0.51	GO:0090309	positive regulation of methylation-dependent chromatin silencing
0.51	GO:0035622	intrahepatic bile duct development
0.51	GO:1901538	changes to DNA methylation involved in embryo development
0.50	GO:0010216	maintenance of DNA methylation
0.50	GO:0051573	negative regulation of histone H3-K9 methylation
0.50	GO:0044030	regulation of DNA methylation
0.50	GO:0051571	positive regulation of histone H3-K4 methylation
0.50	GO:0051567	histone H3-K9 methylation
0.50	GO:0031017	exocrine pancreas development

0.76	GO:0003886	DNA (cytosine-5-)-methyltransferase activity
0.74	GO:0003682	chromatin binding
0.61	GO:0008270	zinc ion binding
0.53	GO:0003677	DNA binding
0.40	GO:0003723	RNA binding
0.38	GO:0000166	nucleotide binding
0.36	GO:0030331	estrogen receptor binding
0.35	GO:0042826	histone deacetylase binding
0.35	GO:0019904	protein domain specific binding

0.59	GO:0005634	nucleus
0.48	GO:0005721	pericentric heterochromatin
0.44	GO:0005657	replication fork
0.35	GO:0043025	neuronal cell body
0.34	GO:0070013	intracellular organelle lumen
0.33	GO:0043234	protein complex
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.76

EC:2.1.1.37

GO:0003886

sp|P26367|PAX6_HUMAN
Paired box protein Pax-6
Search

PAX6

0.88	Paired domain transcription factor variant A

0.68	GO:0007275	multicellular organism development
0.57	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.55	GO:0009786	regulation of asymmetric cell division
0.55	GO:0048505	regulation of timing of cell differentiation
0.54	GO:0002068	glandular epithelial cell development
0.54	GO:2000178	negative regulation of neural precursor cell proliferation
0.54	GO:0035883	enteroendocrine cell differentiation

0.65	GO:0043565	sequence-specific DNA binding
0.55	GO:0070410	co-SMAD binding
0.55	GO:0071837	HMG box domain binding
0.54	GO:0070412	R-SMAD binding
0.54	GO:0035035	histone acetyltransferase binding
0.52	GO:0001047	core promoter binding
0.52	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.51	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.50	GO:0031625	ubiquitin protein ligase binding
0.50	GO:0019901	protein kinase binding

0.61	GO:0005634	nucleus
0.47	GO:0000785	chromatin
0.46	GO:0005829	cytosol
0.46	GO:0070013	intracellular organelle lumen
0.34	GO:0005667	transcription factor complex
0.30	GO:0016020	membrane

0.36

KEGG:R03876

GO:0004842

sp|P26368|U2AF2_HUMAN
Splicing factor U2AF 65 kDa subunit
Search

U2AF2

0.71	U2 snRNP auxiliary factor large subunit

0.72	GO:0008380	RNA splicing
0.69	GO:0006397	mRNA processing
0.53	GO:0048025	negative regulation of mRNA splicing, via spliceosome
0.53	GO:0033120	positive regulation of RNA splicing
0.53	GO:1903146	regulation of autophagy of mitochondrion
0.52	GO:1903955	positive regulation of protein targeting to mitochondrion
0.52	GO:0031397	negative regulation of protein ubiquitination
0.43	GO:0046660	female sex differentiation

0.58	GO:0003723	RNA binding
0.52	GO:0070742	C2H2 zinc finger domain binding
0.46	GO:0019899	enzyme binding

0.60	GO:0005634	nucleus
0.52	GO:0000974	Prp19 complex
0.46	GO:0031974	membrane-enclosed lumen
0.44	GO:0030529	intracellular ribonucleoprotein complex
0.42	GO:0044446	intracellular organelle part
0.36	GO:0019013	viral nucleocapsid

sp|P26371|KRA59_HUMAN
Keratin-associated protein 5-9
Search

0.76	Keratin associated protein 5-7

0.83

GO:0045095

keratin filament

sp|P26373|RL13_HUMAN
60S ribosomal protein L13
Search

RPL13

0.68	Ribosomal protein L13

0.60	GO:0043043	peptide biosynthetic process
0.55	GO:0044267	cellular protein metabolic process
0.53	GO:0010467	gene expression
0.52	GO:0009059	macromolecule biosynthetic process
0.41	GO:0051726	regulation of cell cycle
0.35	GO:0097421	liver regeneration
0.34	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0006508	proteolysis
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.34	GO:0019083	viral transcription

0.63	GO:0003735	structural constituent of ribosome
0.40	GO:0003723	RNA binding
0.36	GO:0004222	metalloendopeptidase activity
0.34	GO:0005515	protein binding
0.34	GO:0008270	zinc ion binding
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005840	ribosome
0.47	GO:0005829	cytosol
0.45	GO:0005730	nucleolus
0.44	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane

0.36

GO:0004222

sp|P26374|RAE2_HUMAN
Rab proteins geranylgeranyltransferase component A 2
Search

CHM

0.94	Rab proteins geranylgeranyltransferase component A 2

0.84	GO:0018344	protein geranylgeranylation
0.77	GO:0007264	small GTPase mediated signal transduction
0.69	GO:0006886	intracellular protein transport
0.69	GO:0050790	regulation of catalytic activity
0.46	GO:0090150	establishment of protein localization to membrane
0.44	GO:0048798	swim bladder inflation
0.44	GO:0050935	iridophore differentiation
0.43	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
0.43	GO:0010842	retina layer formation
0.42	GO:0042491	inner ear auditory receptor cell differentiation

0.83	GO:0005092	GDP-dissociation inhibitor activity
0.54	GO:0017137	Rab GTPase binding
0.45	GO:0016740	transferase activity
0.39	GO:0005096	GTPase activator activity
0.37	GO:0140096	catalytic activity, acting on a protein
0.34	GO:0004930	G-protein coupled receptor activity
0.34	GO:0032403	protein complex binding

0.84	GO:0005968	Rab-protein geranylgeranyltransferase complex
0.48	GO:0005829	cytosol
0.41	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.45

GO:0016740

sp|P26378|ELAV4_HUMAN
ELAV-like protein 4
Search

ELAVL4

0.81	ELAV-like protein 4

0.71	GO:0048813	dendrite morphogenesis
0.71	GO:0007612	learning
0.69	GO:0007626	locomotory behavior
0.62	GO:1990090	cellular response to nerve growth factor stimulus
0.61	GO:0042220	response to cocaine
0.60	GO:1900006	positive regulation of dendrite development
0.59	GO:0043488	regulation of mRNA stability
0.59	GO:0031099	regeneration
0.57	GO:0007568	aging
0.57	GO:0034976	response to endoplasmic reticulum stress

0.83	GO:0017091	AU-rich element binding
0.72	GO:0003729	mRNA binding
0.48	GO:0005515	protein binding

0.59	GO:0042788	polysomal ribosome
0.59	GO:0030426	growth cone
0.57	GO:0043025	neuronal cell body
0.57	GO:0030425	dendrite
0.54	GO:0005635	nuclear envelope
0.51	GO:0005856	cytoskeleton
0.50	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|P26436|ASPX_HUMAN
Acrosomal protein SP-10
Search

ACRV1

0.97	Acrosomal vesicle protein 1

0.37

GO:0007275

multicellular organism development

0.84

GO:0001669

acrosomal vesicle

sp|P26439|3BHS2_HUMAN
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
Search

0.50	3 beta-hydroxysteroid dehydrogenase isomerase VI

0.78	GO:0006694	steroid biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.40	GO:0008209	androgen metabolic process
0.39	GO:0042446	hormone biosynthetic process
0.39	GO:0008212	mineralocorticoid metabolic process
0.38	GO:0008207	C21-steroid hormone metabolic process
0.38	GO:0008211	glucocorticoid metabolic process
0.38	GO:0014070	response to organic cyclic compound
0.37	GO:0010288	response to lead ion
0.37	GO:0033327	Leydig cell differentiation

0.83	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
0.54	GO:0004769	steroid delta-isomerase activity
0.53	GO:0102294	cholesterol dehydrogenase activity
0.38	GO:0010181	FMN binding
0.36	GO:0005496	steroid binding
0.36	GO:0035410	dihydrotestosterone 17-beta-dehydrogenase activity
0.35	GO:0030283	testosterone dehydrogenase [NAD(P)] activity
0.35	GO:0051287	NAD binding
0.34	GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity
0.33	GO:0016651	oxidoreductase activity, acting on NAD(P)H

0.45	GO:0005789	endoplasmic reticulum membrane
0.44	GO:0005758	mitochondrial intermembrane space
0.44	GO:0031966	mitochondrial membrane
0.41	GO:0019866	organelle inner membrane
0.40	GO:0097425	smooth endoplasmic reticulum part
0.36	GO:0098588	bounding membrane of organelle
0.30	GO:0016021	integral component of membrane

0.83

EC:1.1.1.145

GO:0003854

sp|P26440|IVD_HUMAN
Isovaleryl-CoA dehydrogenase, mitochondrial
Search

IVD

0.52	Isovaleryl Coenzyme A dehydrogenase

0.53	GO:0055114	oxidation-reduction process
0.42	GO:0006552	leucine catabolic process
0.37	GO:0009062	fatty acid catabolic process
0.36	GO:0030258	lipid modification
0.34	GO:0051260	protein homooligomerization
0.33	GO:0019538	protein metabolic process
0.33	GO:0043043	peptide biosynthetic process
0.32	GO:0010467	gene expression
0.32	GO:0009059	macromolecule biosynthetic process
0.32	GO:0044260	cellular macromolecule metabolic process

0.74	GO:0003995	acyl-CoA dehydrogenase activity
0.66	GO:0050660	flavin adenine dinucleotide binding
0.33	GO:0004252	serine-type endopeptidase activity
0.33	GO:0003735	structural constituent of ribosome

0.47	GO:0005654	nucleoplasm
0.44	GO:0005739	mitochondrion
0.35	GO:0031967	organelle envelope
0.35	GO:0031090	organelle membrane
0.33	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.74

EC:1.3.99.3

GO:0003995

sp|P26441|CNTF_HUMAN
Ciliary neurotrophic factor
Search

CNTF

0.97	Ciliary neurotrophic factor

0.78	GO:0040007	growth
0.75	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway
0.72	GO:0046533	negative regulation of photoreceptor cell differentiation
0.72	GO:0046668	regulation of retinal cell programmed cell death
0.71	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
0.69	GO:0043524	negative regulation of neuron apoptotic process
0.68	GO:0048644	muscle organ morphogenesis
0.64	GO:0008284	positive regulation of cell proliferation
0.63	GO:0010469	regulation of receptor activity
0.63	GO:0048666	neuron development

0.72	GO:0005138	interleukin-6 receptor binding
0.65	GO:0008083	growth factor activity
0.57	GO:0005127	ciliary neurotrophic factor receptor binding
0.52	GO:0005125	cytokine activity
0.37	GO:0019888	protein phosphatase regulator activity
0.33	GO:0003676	nucleic acid binding

0.74	GO:0097058	CRLF-CLCF1 complex
0.52	GO:0030424	axon
0.49	GO:0005737	cytoplasm
0.37	GO:0043025	neuronal cell body
0.37	GO:0000159	protein phosphatase type 2A complex
0.37	GO:0120038	plasma membrane bounded cell projection part
0.35	GO:0005634	nucleus

sp|P26447|S10A4_HUMAN
Protein S100-A4
Search

sp|P26572|MGAT1_HUMAN
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Search

MGAT1

0.90	N-acetylglucosaminyltransferase I mutant

0.74	GO:0043413	macromolecule glycosylation
0.74	GO:0009101	glycoprotein biosynthetic process
0.60	GO:0036211	protein modification process
0.57	GO:0006049	UDP-N-acetylglucosamine catabolic process
0.56	GO:0044267	cellular protein metabolic process
0.51	GO:0001701	in utero embryonic development
0.45	GO:0035283	central nervous system segmentation
0.44	GO:0035010	encapsulation of foreign target
0.44	GO:0016319	mushroom body development
0.43	GO:0008340	determination of adult lifespan

0.77	GO:0008375	acetylglucosaminyltransferase activity
0.49	GO:0140103	catalytic activity, acting on a glycoprotein
0.35	GO:0046872	metal ion binding
0.34	GO:0003924	GTPase activity
0.34	GO:0032550	purine ribonucleoside binding
0.34	GO:0019001	guanyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0005797	Golgi medial cisterna
0.38	GO:0000139	Golgi membrane
0.37	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.77

GO:0008375

sp|P26583|HMGB2_HUMAN
High mobility group protein B2
Search

HMGB2

0.82	High mobility group box 2

0.68	GO:0002437	inflammatory response to antigenic stimulus
0.64	GO:0050830	defense response to Gram-positive bacterium
0.63	GO:0050829	defense response to Gram-negative bacterium
0.62	GO:0032496	response to lipopolysaccharide
0.62	GO:0072091	regulation of stem cell proliferation
0.59	GO:0032392	DNA geometric change
0.58	GO:0050767	regulation of neurogenesis
0.56	GO:0043388	positive regulation of DNA binding
0.56	GO:0045654	positive regulation of megakaryocyte differentiation
0.56	GO:0001938	positive regulation of endothelial cell proliferation

0.74	GO:0008301	DNA binding, bending
0.71	GO:0000400	four-way junction DNA binding
0.71	GO:0097100	supercoiled DNA binding
0.62	GO:0001158	enhancer sequence-specific DNA binding
0.59	GO:0000405	bubble DNA binding
0.56	GO:0008134	transcription factor binding
0.56	GO:0050786	RAGE receptor binding
0.55	GO:0042056	chemoattractant activity
0.50	GO:0003684	damaged DNA binding
0.47	GO:0019904	protein domain specific binding

0.61	GO:0005634	nucleus
0.58	GO:0005615	extracellular space
0.55	GO:0000785	chromatin
0.52	GO:0000793	condensed chromosome
0.52	GO:0070013	intracellular organelle lumen
0.51	GO:0048471	perinuclear region of cytoplasm
0.44	GO:0043234	protein complex
0.40	GO:0017053	transcriptional repressor complex
0.39	GO:0009986	cell surface
0.38	GO:0005768	endosome

0.36

EC:4

GO:0016829

sp|P26599|PTBP1_HUMAN
Polypyrimidine tract-binding protein 1
Search

PTBP1

0.92	Polypyrimidine tract-binding protein 1

0.69	GO:0006397	mRNA processing
0.52	GO:0075522	IRES-dependent viral translational initiation
0.52	GO:0048025	negative regulation of mRNA splicing, via spliceosome
0.51	GO:0051148	negative regulation of muscle cell differentiation
0.50	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.39	GO:0008380	RNA splicing
0.36	GO:0045944	positive regulation of transcription by RNA polymerase II
0.36	GO:1904411	positive regulation of secretory granule organization
0.36	GO:0008543	fibroblast growth factor receptor signaling pathway
0.35	GO:0070935	3'-UTR-mediated mRNA stabilization

0.59	GO:0003723	RNA binding
0.35	GO:0005515	protein binding
0.34	GO:0000014	single-stranded DNA endodeoxyribonuclease activity
0.34	GO:0001067	regulatory region nucleic acid binding
0.34	GO:0003697	single-stranded DNA binding
0.33	GO:0043565	sequence-specific DNA binding

0.60	GO:0005634	nucleus
0.37	GO:0070062	extracellular exosome
0.34	GO:0044306	neuron projection terminus
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0044446	intracellular organelle part
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|P26639|SYTC_HUMAN
Threonine--tRNA ligase, cytoplasmic
Search

TARS

0.68	Threonyl-tRNA synthetase

0.78	GO:0006435	threonyl-tRNA aminoacylation
0.45	GO:0001569	branching involved in blood vessel morphogenesis
0.45	GO:1903670	regulation of sprouting angiogenesis

0.79	GO:0004829	threonine-tRNA ligase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005515	protein binding
0.34	GO:0000049	tRNA binding

0.49	GO:0005737	cytoplasm
0.48	GO:0015629	actin cytoskeleton
0.36	GO:0070062	extracellular exosome

0.79

EC:6.1.1.3

GO:0004829

sp|P26640|SYVC_HUMAN
Valine--tRNA ligase
Search

VARS

0.46	Valyl-tRNA synthetase

0.77	GO:0006438	valyl-tRNA aminoacylation
0.72	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity
0.36	GO:0006397	mRNA processing

0.77	GO:0004832	valine-tRNA ligase activity
0.73	GO:0002161	aminoacyl-tRNA editing activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding

0.49	GO:0005829	cytosol
0.43	GO:0005739	mitochondrion
0.35	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0016020	membrane

0.77	EC:6.1.1.9	GO:0004832
0.77	KEGG:R03665	GO:0004832

sp|P26641|EF1G_HUMAN
Elongation factor 1-gamma
Search

EEF1G

0.70	Eukaryotic translation elongation factor 1 gamma

0.68	GO:0006414	translational elongation
0.50	GO:0009615	response to virus
0.44	GO:0006749	glutathione metabolic process
0.35	GO:0006378	mRNA polyadenylation
0.33	GO:0006351	transcription, DNA-templated

0.69	GO:0003746	translation elongation factor activity
0.51	GO:0045296	cadherin binding
0.45	GO:0004364	glutathione transferase activity
0.36	GO:0050265	RNA uridylyltransferase activity
0.35	GO:0003730	mRNA 3'-UTR binding
0.34	GO:0003899	DNA-directed 5'-3' RNA polymerase activity

0.47	GO:0005783	endoplasmic reticulum
0.40	GO:0005634	nucleus
0.37	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.45

EC:2.5.1.18

GO:0004364

sp|P26651|TTP_HUMAN
mRNA decay activator protein ZFP36
Search

ZFP36

0.96	Tristetraproline

0.67	GO:1904246	negative regulation of polynucleotide adenylyltransferase activity
0.65	GO:0045085	negative regulation of interleukin-2 biosynthetic process
0.64	GO:0061158	3'-UTR-mediated mRNA destabilization
0.64	GO:0038066	p38MAPK cascade
0.63	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
0.62	GO:0045600	positive regulation of fat cell differentiation
0.61	GO:0035278	miRNA mediated inhibition of translation
0.61	GO:0045638	negative regulation of myeloid cell differentiation
0.60	GO:0071356	cellular response to tumor necrosis factor
0.60	GO:0071222	cellular response to lipopolysaccharide

0.64	GO:0035925	mRNA 3'-UTR AU-rich region binding
0.63	GO:0071889	14-3-3 protein binding
0.56	GO:0070063	RNA polymerase binding
0.54	GO:0046872	metal ion binding
0.42	GO:0031072	heat shock protein binding
0.42	GO:0019957	C-C chemokine binding
0.39	GO:0019901	protein kinase binding
0.36	GO:0003677	DNA binding
0.36	GO:0003727	single-stranded RNA binding
0.33	GO:0070577	lysine-acetylated histone binding

0.59	GO:0030014	CCR4-NOT complex
0.52	GO:0005829	cytosol
0.47	GO:0005634	nucleus
0.47	GO:0030529	intracellular ribonucleoprotein complex
0.46	GO:0098745	Dcp1-Dcp2 complex
0.45	GO:0070578	RISC-loading complex
0.42	GO:0000178	exosome (RNase complex)
0.37	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016020	membrane

sp|P26678|PPLA_HUMAN
Cardiac phospholamban
Search

PLN

0.97	Cardiac phospholamban

0.77	GO:0006816	calcium ion transport
0.72	GO:0043086	negative regulation of catalytic activity
0.69	GO:1901877	negative regulation of calcium ion binding
0.68	GO:0086023	adrenergic receptor signaling pathway involved in heart process
0.68	GO:0086092	regulation of the force of heart contraction by cardiac conduction
0.66	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
0.66	GO:1901894	regulation of calcium-transporting ATPase activity
0.66	GO:1901077	regulation of relaxation of muscle
0.65	GO:0010459	negative regulation of heart rate
0.65	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity

0.85	GO:0005246	calcium channel regulator activity
0.82	GO:0042030	ATPase inhibitor activity
0.39	GO:0051117	ATPase binding
0.37	GO:0042802	identical protein binding

0.83	GO:0033017	sarcoplasmic reticulum membrane
0.68	GO:0090534	calcium ion-transporting ATPase complex
0.59	GO:0031966	mitochondrial membrane
0.39	GO:0031982	vesicle
0.38	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0043234	protein complex

sp|P26715|NKG2A_HUMAN
NKG2-A/NKG2-B type II integral membrane protein
Search

0.95	NK cell receptor C

0.38	GO:0006968	cellular defense response
0.35	GO:0002228	natural killer cell mediated immunity
0.35	GO:0007165	signal transduction
0.34	GO:0050776	regulation of immune response

0.67	GO:0030246	carbohydrate binding
0.48	GO:0023024	MHC class I protein complex binding
0.39	GO:1990405	protein antigen binding
0.36	GO:0099600	transmembrane receptor activity
0.36	GO:0038023	signaling receptor activity

0.43	GO:0043235	receptor complex
0.35	GO:0005887	integral component of plasma membrane

sp|P26717|NKG2C_HUMAN
NKG2-C type II integral membrane protein
Search

0.96	NK cell receptor C

0.39	GO:0006968	cellular defense response
0.36	GO:0002228	natural killer cell mediated immunity
0.35	GO:0007165	signal transduction
0.34	GO:0050776	regulation of immune response

0.67	GO:0030246	carbohydrate binding
0.46	GO:0023024	MHC class I protein complex binding
0.38	GO:1990405	protein antigen binding
0.36	GO:0099600	transmembrane receptor activity
0.36	GO:0038023	signaling receptor activity

0.42	GO:0043235	receptor complex
0.35	GO:0005887	integral component of plasma membrane

sp|P26718|NKG2D_HUMAN
NKG2-D type II integral membrane protein
Search

KLRK1

0.96	Killer cell lectin like receptor K1

0.70	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
0.70	GO:2000502	negative regulation of natural killer cell chemotaxis
0.66	GO:0042267	natural killer cell mediated cytotoxicity
0.66	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.65	GO:0034260	negative regulation of GTPase activity
0.64	GO:0030101	natural killer cell activation
0.63	GO:0045429	positive regulation of nitric oxide biosynthetic process
0.63	GO:0032729	positive regulation of interferon-gamma production
0.62	GO:0050830	defense response to Gram-positive bacterium
0.61	GO:0071222	cellular response to lipopolysaccharide

0.69	GO:0032394	MHC class Ib receptor activity
0.69	GO:0030246	carbohydrate binding
0.65	GO:0042288	MHC class I protein binding
0.56	GO:0042803	protein homodimerization activity
0.38	GO:0019900	kinase binding

0.61	GO:0009986	cell surface
0.56	GO:0098552	side of membrane
0.49	GO:0044459	plasma membrane part
0.30	GO:0016021	integral component of membrane

sp|P26842|CD27_HUMAN
CD27 antigen
Search

sp|P26885|FKBP2_HUMAN
Peptidyl-prolyl cis-trans isomerase FKBP2
Search

FKBP2

0.56	Peptidyl-prolyl cis-trans isomerase FKBP2

0.69	GO:0061077	chaperone-mediated protein folding
0.64	GO:0000413	protein peptidyl-prolyl isomerization

0.75	GO:0005528	FK506 binding
0.64	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.46	GO:0005515	protein binding

0.64	GO:0005789	endoplasmic reticulum membrane
0.54	GO:0070062	extracellular exosome

0.64

GO:0003755

sp|P26927|HGFL_HUMAN
Hepatocyte growth factor-like protein
Search

MST1

0.66	Hepatocyte growth factor

0.61	GO:0006508	proteolysis
0.51	GO:0010469	regulation of receptor activity
0.48	GO:0008284	positive regulation of cell proliferation
0.47	GO:0048012	hepatocyte growth factor receptor signaling pathway
0.45	GO:0061138	morphogenesis of a branching epithelium
0.44	GO:0051241	negative regulation of multicellular organismal process
0.44	GO:0001934	positive regulation of protein phosphorylation
0.44	GO:2000026	regulation of multicellular organismal development
0.43	GO:0014842	regulation of skeletal muscle satellite cell proliferation
0.43	GO:1902947	regulation of tau-protein kinase activity

0.69	GO:0004252	serine-type endopeptidase activity
0.52	GO:0008083	growth factor activity
0.42	GO:0042056	chemoattractant activity
0.39	GO:0042802	identical protein binding
0.30	GO:0019900	kinase binding

0.42	GO:0005615	extracellular space
0.34	GO:0005773	vacuole
0.30	GO:0031982	vesicle
0.30	GO:0043230	extracellular organelle

0.69

GO:0004252

sp|P26951|IL3RA_HUMAN
Interleukin-3 receptor subunit alpha
Search

IL3RA

0.97	Interleukin-3 receptor subunit alpha

0.77	GO:0019221	cytokine-mediated signaling pathway
0.49	GO:0036015	response to interleukin-3
0.45	GO:0000165	MAPK cascade
0.44	GO:0018108	peptidyl-tyrosine phosphorylation
0.41	GO:0065009	regulation of molecular function

0.79	GO:0004896	cytokine receptor activity
0.44	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.44	GO:0004713	protein tyrosine kinase activity

0.38	GO:0005886	plasma membrane
0.35	GO:0005622	intracellular
0.30	GO:0031224	intrinsic component of membrane

0.44

GO:0004713

sp|P26992|CNTFR_HUMAN
Ciliary neurotrophic factor receptor subunit alpha
Search

CNTFR

0.97	Ciliary neurotrophic factor receptor subunit alpha

0.77	GO:0019221	cytokine-mediated signaling pathway
0.64	GO:0003360	brainstem development
0.62	GO:0001967	suckling behavior
0.59	GO:0043524	negative regulation of neuron apoptotic process
0.58	GO:0060538	skeletal muscle organ development
0.57	GO:0007548	sex differentiation
0.56	GO:0008284	positive regulation of cell proliferation
0.41	GO:0048680	positive regulation of axon regeneration

0.79	GO:0004896	cytokine receptor activity
0.59	GO:0019955	cytokine binding
0.52	GO:0005102	receptor binding

0.64	GO:0097059	CNTFR-CLCF1 complex
0.63	GO:0070110	ciliary neurotrophic factor receptor complex
0.57	GO:0016324	apical plasma membrane
0.41	GO:0031225	anchored component of membrane
0.35	GO:0019898	extrinsic component of membrane

sp|P26998|CRBB3_HUMAN
Beta-crystallin B3
Search

CRYBB3

0.97	Beta-crystallin B3

0.73	GO:0007601	visual perception
0.39	GO:0043010	camera-type eye development
0.34	GO:0006468	protein phosphorylation
0.33	GO:0007165	signal transduction

0.81	GO:0005212	structural constituent of eye lens
0.38	GO:0042803	protein homodimerization activity
0.37	GO:0047696	beta-adrenergic receptor kinase activity
0.35	GO:0004703	G-protein coupled receptor kinase activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.37

EC:2.7.11.15

GO:0047696

sp|P27037|AVR2A_HUMAN
Activin receptor type-2A
Search

ACVR2A

0.74	Serine/threonine-protein kinase receptor

0.80	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.66	GO:0023014	signal transduction by protein phosphorylation
0.59	GO:0043084	penile erection
0.59	GO:0032927	positive regulation of activin receptor signaling pathway
0.59	GO:0042713	sperm ejaculation
0.58	GO:0060011	Sertoli cell proliferation
0.58	GO:0045648	positive regulation of erythrocyte differentiation
0.57	GO:0030501	positive regulation of bone mineralization
0.57	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.57	GO:0045669	positive regulation of osteoblast differentiation

0.81	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
0.79	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
0.59	GO:0048185	activin binding
0.59	GO:0034711	inhibin binding
0.57	GO:0015026	coreceptor activity
0.55	GO:0043621	protein self-association
0.55	GO:0030165	PDZ domain binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.60	GO:0034673	inhibin-betaglycan-ActRII complex
0.54	GO:0043235	receptor complex
0.51	GO:0009986	cell surface
0.39	GO:0005737	cytoplasm
0.34	GO:0005887	integral component of plasma membrane
0.34	GO:1902554	serine/threonine protein kinase complex

0.81

GO:0004675

sp|P27105|STOM_HUMAN
Erythrocyte band 7 integral membrane protein
Search

STOM

0.89	Erythrocyte band 7 integral membrane protein stomatin

0.56	GO:1901585	regulation of acid-sensing ion channel activity
0.55	GO:0044829	positive regulation by host of viral genome replication
0.54	GO:0090314	positive regulation of protein targeting to membrane
0.50	GO:0051260	protein homooligomerization
0.35	GO:0043312	neutrophil degranulation

0.49	GO:0070063	RNA polymerase binding
0.48	GO:0042803	protein homodimerization activity

0.65	GO:0005887	integral component of plasma membrane
0.51	GO:0045121	membrane raft
0.50	GO:0048471	perinuclear region of cytoplasm
0.47	GO:0005783	endoplasmic reticulum
0.46	GO:0005856	cytoskeleton
0.43	GO:0005739	mitochondrion
0.37	GO:0072562	blood microparticle
0.36	GO:0042470	melanosome
0.36	GO:0070062	extracellular exosome
0.35	GO:0035579	specific granule membrane

sp|P27144|KAD4_HUMAN
Adenylate kinase 4, mitochondrial
Search

AK4

0.94	Adenylate kinase isoenzyme 4, mitochondrial

0.72	GO:0006172	ADP biosynthetic process
0.68	GO:0046939	nucleotide phosphorylation
0.68	GO:0046039	GTP metabolic process
0.66	GO:0046033	AMP metabolic process
0.64	GO:0046041	ITP metabolic process
0.49	GO:0046034	ATP metabolic process
0.46	GO:0046051	UTP metabolic process
0.45	GO:0009142	nucleoside triphosphate biosynthetic process
0.41	GO:0048513	animal organ development
0.39	GO:0061008	hepaticobiliary system development

0.77	GO:0046899	nucleoside triphosphate adenylate kinase activity
0.77	GO:0004017	adenylate kinase activity
0.58	GO:0004550	nucleoside diphosphate kinase activity
0.57	GO:0032550	purine ribonucleoside binding
0.57	GO:0019001	guanyl nucleotide binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0050145	nucleoside phosphate kinase activity
0.33	GO:0005515	protein binding

0.67	GO:0005759	mitochondrial matrix
0.36	GO:0070062	extracellular exosome
0.34	GO:0005740	mitochondrial envelope
0.33	GO:0019866	organelle inner membrane
0.33	GO:0031970	organelle envelope lumen
0.32	GO:0005829	cytosol

0.77

EC:2.7.4.10

GO:0046899

sp|P27169|PON1_HUMAN
Serum paraoxonase/arylesterase 1
Search

PON1

0.90	Paraoxonase

0.66	GO:0010875	positive regulation of cholesterol efflux
0.63	GO:0032411	positive regulation of transporter activity
0.62	GO:0051099	positive regulation of binding
0.61	GO:0019439	aromatic compound catabolic process
0.61	GO:0046470	phosphatidylcholine metabolic process
0.61	GO:0008203	cholesterol metabolic process
0.57	GO:0009636	response to toxic substance
0.56	GO:0046395	carboxylic acid catabolic process
0.55	GO:0046434	organophosphate catabolic process
0.54	GO:0016311	dephosphorylation

0.85	GO:0004064	arylesterase activity
0.69	GO:0004063	aryldialkylphosphatase activity
0.67	GO:0042802	identical protein binding
0.57	GO:0005543	phospholipid binding
0.56	GO:0046983	protein dimerization activity
0.54	GO:0005509	calcium ion binding

0.67	GO:0034366	spherical high-density lipoprotein particle
0.43	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.85

EC:3.1.1.2

GO:0004064

sp|P27216|ANX13_HUMAN
Annexin A13
Search

ANXA13

0.57

Annexin

0.39	GO:0042997	negative regulation of Golgi to plasma membrane protein transport
0.38	GO:0042998	positive regulation of Golgi to plasma membrane protein transport
0.36	GO:0051241	negative regulation of multicellular organismal process
0.36	GO:0050818	regulation of coagulation
0.36	GO:0030154	cell differentiation
0.35	GO:2000482	regulation of interleukin-8 secretion
0.35	GO:0032088	negative regulation of NF-kappaB transcription factor activity
0.35	GO:0050709	negative regulation of protein secretion
0.34	GO:0007219	Notch signaling pathway
0.34	GO:0060429	epithelium development

0.81	GO:0005544	calcium-dependent phospholipid binding
0.70	GO:0005509	calcium ion binding
0.40	GO:1901611	phosphatidylglycerol binding
0.40	GO:0001786	phosphatidylserine binding
0.38	GO:0031210	phosphatidylcholine binding
0.35	GO:0051059	NF-kappaB binding
0.35	GO:0048306	calcium-dependent protein binding
0.34	GO:0042802	identical protein binding
0.34	GO:0005200	structural constituent of cytoskeleton
0.33	GO:0003924	GTPase activity

0.51	GO:0005654	nucleoplasm
0.44	GO:0005886	plasma membrane
0.38	GO:0031982	vesicle
0.37	GO:0045177	apical part of cell
0.37	GO:0045121	membrane raft
0.37	GO:0043230	extracellular organelle
0.36	GO:0012505	endomembrane system
0.36	GO:0005615	extracellular space
0.34	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0009986	cell surface

sp|P27338|AOFB_HUMAN
Amine oxidase [flavin-containing] B
Search

MAOB

0.49	Amine oxidase [flavin-containing] B

0.52	GO:0055114	oxidation-reduction process
0.52	GO:0042420	dopamine catabolic process
0.41	GO:0042135	neurotransmitter catabolic process
0.39	GO:0014063	negative regulation of serotonin secretion
0.39	GO:0010269	response to selenium ion
0.39	GO:0045964	positive regulation of dopamine metabolic process
0.39	GO:0051412	response to corticosterone
0.39	GO:0010044	response to aluminum ion
0.38	GO:0045471	response to ethanol
0.37	GO:0032496	response to lipopolysaccharide

0.54	GO:0016491	oxidoreductase activity
0.37	GO:0042803	protein homodimerization activity
0.36	GO:0050660	flavin adenine dinucleotide binding
0.35	GO:0051378	serotonin binding

0.48	GO:0005739	mitochondrion
0.46	GO:0031967	organelle envelope
0.46	GO:0031090	organelle membrane
0.43	GO:0098805	whole membrane
0.41	GO:0019867	outer membrane
0.36	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.54

GO:0016491

sp|P27348|1433T_HUMAN
14-3-3 protein theta
Search

YWHAQ

0.97	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta

0.48	GO:0007264	small GTPase mediated signal transduction
0.48	GO:0045892	negative regulation of transcription, DNA-templated
0.47	GO:0006605	protein targeting
0.40	GO:0090168	Golgi reassembly
0.40	GO:0051683	establishment of Golgi localization
0.39	GO:0034766	negative regulation of ion transmembrane transport
0.38	GO:0010941	regulation of cell death
0.37	GO:0021762	substantia nigra development
0.36	GO:0055114	oxidation-reduction process
0.35	GO:0006839	mitochondrial transport

0.77	GO:0019904	protein domain specific binding
0.54	GO:0047485	protein N-terminus binding
0.50	GO:0042802	identical protein binding
0.42	GO:0044325	ion channel binding
0.39	GO:0004497	monooxygenase activity
0.39	GO:0071889	14-3-3 protein binding
0.38	GO:0008022	protein C-terminus binding
0.38	GO:0045296	cadherin binding
0.38	GO:0031625	ubiquitin protein ligase binding
0.38	GO:0019901	protein kinase binding

0.43	GO:0043234	protein complex
0.39	GO:0005737	cytoplasm
0.38	GO:0031982	vesicle
0.37	GO:0005925	focal adhesion
0.37	GO:0043230	extracellular organelle
0.36	GO:0005615	extracellular space
0.35	GO:0005634	nucleus
0.34	GO:0031090	organelle membrane
0.34	GO:0014069	postsynaptic density
0.34	GO:0031252	cell leading edge

0.34

GO:0004222

sp|P27352|IF_HUMAN
Gastric intrinsic factor
Search

GIF

0.97	Gastric intrinsic factor

0.78	GO:0015889	cobalamin transport
0.44	GO:0006824	cobalt ion transport
0.39	GO:0009235	cobalamin metabolic process
0.37	GO:0043043	peptide biosynthetic process
0.36	GO:0044267	cellular protein metabolic process
0.36	GO:0010467	gene expression
0.35	GO:0009059	macromolecule biosynthetic process
0.35	GO:0006886	intracellular protein transport
0.35	GO:0016192	vesicle-mediated transport

0.75	GO:0031419	cobalamin binding
0.38	GO:0003735	structural constituent of ribosome
0.35	GO:0019843	rRNA binding

0.70	GO:0005902	microvillus
0.67	GO:0016324	apical plasma membrane
0.63	GO:0005768	endosome
0.61	GO:0005615	extracellular space
0.39	GO:0043202	lysosomal lumen
0.37	GO:0005840	ribosome
0.36	GO:0030117	membrane coat
0.30	GO:0031224	intrinsic component of membrane

sp|P27361|MK03_HUMAN
Mitogen-activated protein kinase 3
Search

MAPK3

0.57	Mitogen-activated protein kinase

0.79	GO:0000165	MAPK cascade
0.59	GO:0060440	trachea formation
0.58	GO:0042473	outer ear morphogenesis
0.58	GO:0061308	cardiac neural crest cell development involved in heart development
0.58	GO:0060020	Bergmann glial cell differentiation
0.58	GO:1903351	cellular response to dopamine
0.57	GO:1904355	positive regulation of telomere capping
0.57	GO:0070849	response to epidermal growth factor
0.57	GO:0030878	thyroid gland development
0.57	GO:0071276	cellular response to cadmium ion

0.81	GO:0004707	MAP kinase activity
0.57	GO:0004708	MAP kinase kinase activity
0.56	GO:0001784	phosphotyrosine residue binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0019902	phosphatase binding
0.54	GO:0008144	drug binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0042802	identical protein binding
0.44	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity

0.57	GO:0031143	pseudopodium
0.50	GO:0005901	caveola
0.50	GO:0005829	cytosol
0.49	GO:0005925	focal adhesion
0.48	GO:0005770	late endosome
0.48	GO:0005769	early endosome
0.48	GO:0005635	nuclear envelope
0.45	GO:0005794	Golgi apparatus
0.44	GO:0005856	cytoskeleton
0.43	GO:0005739	mitochondrion

0.81	EC:2.7.11.24	GO:0004707
0.81	KEGG:R00162	GO:0004707

sp|P27448|MARK3_HUMAN
MAP/microtubule affinity-regulating kinase 3
Search

MARK3

0.59	Non-specific serine/threonine protein kinase

0.81	GO:0030010	establishment of cell polarity
0.76	GO:0000226	microtubule cytoskeleton organization
0.63	GO:0006468	protein phosphorylation
0.39	GO:0035331	negative regulation of hippo signaling
0.33	GO:0035556	intracellular signal transduction

0.70	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005515	protein binding

0.36	GO:0070062	extracellular exosome
0.34	GO:0005886	plasma membrane
0.34	GO:0005829	cytosol

0.70

GO:0004674

sp|P27449|VATL_HUMAN
V-type proton ATPase 16 kDa proteolipid subunit
Search

ATP6V0C

0.61	V-type proton ATPase proteolipid subunit

0.76	GO:0015991	ATP hydrolysis coupled proton transport
0.51	GO:0030177	positive regulation of Wnt signaling pathway
0.51	GO:0007042	lysosomal lumen acidification
0.41	GO:0060036	notochord cell vacuolation
0.40	GO:0001878	response to yeast
0.40	GO:0060059	embryonic retina morphogenesis in camera-type eye
0.35	GO:0090383	phagosome acidification
0.35	GO:0033572	transferrin transport
0.35	GO:0043312	neutrophil degranulation
0.35	GO:0008286	insulin receptor signaling pathway

0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.49	GO:0031625	ubiquitin protein ligase binding
0.47	GO:0036442	proton-exporting ATPase activity
0.44	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
0.34	GO:0005245	voltage-gated calcium channel activity
0.34	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
0.34	GO:0008448	N-acetylglucosamine-6-phosphate deacetylase activity

0.78	GO:0033179	proton-transporting V-type ATPase, V0 domain
0.76	GO:0005774	vacuolar membrane
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.36	GO:0099503	secretory vesicle
0.36	GO:0005764	lysosome
0.35	GO:0012505	endomembrane system
0.35	GO:0030670	phagocytic vesicle membrane
0.34	GO:0048786	presynaptic active zone
0.32	GO:0005886	plasma membrane

0.34

EC:3.5.1.25

GO:0008448

sp|P27469|G0S2_HUMAN
G0/G1 switch protein 2
Search

G0S2

0.97	G0/G1 switch regulatory protein 2

0.74	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
0.73	GO:0097191	extrinsic apoptotic signaling pathway
0.38	GO:0019216	regulation of lipid metabolic process
0.36	GO:0007049	cell cycle

0.36

GO:0005515

protein binding

0.54	GO:0005739	mitochondrion
0.39	GO:0005811	lipid droplet
0.30	GO:0044425	membrane part

sp|P27482|CALL3_HUMAN
Calmodulin-like protein 3
Search

0.60	EF-hand domain

0.35	GO:1990954	establishment of protein localization to meiotic spindle pole body
0.34	GO:0090307	mitotic spindle assembly

0.70	GO:0005509	calcium ion binding
0.34	GO:0005515	protein binding

0.36	GO:0070062	extracellular exosome
0.35	GO:0035840	old growing cell tip
0.35	GO:0035841	new growing cell tip
0.34	GO:0035974	meiotic spindle pole body
0.34	GO:0000935	division septum
0.34	GO:0044732	mitotic spindle pole body
0.34	GO:0042995	cell projection
0.32	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|P27487|DPP4_HUMAN
Dipeptidyl peptidase 4
Search

DPP4

0.83	Venom dipeptidylpeptidase IV

0.61

GO:0006508

proteolysis

0.69

GO:0004252

serine-type endopeptidase activity

0.30

GO:0031224

intrinsic component of membrane

0.69

GO:0004252

sp|P27539|GDF1_HUMAN
Embryonic growth/differentiation factor 1
Search

GDF1

0.95	Embryonic growth/differentiation factor 1

0.76	GO:0010469	regulation of receptor activity
0.57	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.56	GO:0060395	SMAD protein signal transduction
0.56	GO:0030509	BMP signaling pathway
0.53	GO:0043408	regulation of MAPK cascade
0.51	GO:0048468	cell development
0.51	GO:0042981	regulation of apoptotic process
0.46	GO:0007492	endoderm development
0.46	GO:0007498	mesoderm development
0.45	GO:0001701	in utero embryonic development

0.78	GO:0008083	growth factor activity
0.56	GO:0005160	transforming growth factor beta receptor binding
0.54	GO:0005125	cytokine activity

0.66

GO:0005576

extracellular region

sp|P27540|ARNT_HUMAN
Aryl hydrocarbon receptor nuclear translocator
Search

ARNT

0.90	Aryl hydrocarbon receptor nuclear translocator

0.60	GO:0033235	positive regulation of protein sumoylation
0.60	GO:0046886	positive regulation of hormone biosynthetic process
0.59	GO:0010575	positive regulation of vascular endothelial growth factor production
0.59	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
0.57	GO:0006351	transcription, DNA-templated
0.56	GO:0001666	response to hypoxia
0.56	GO:0001892	embryonic placenta development
0.55	GO:0030522	intracellular receptor signaling pathway
0.54	GO:0045893	positive regulation of transcription, DNA-templated
0.51	GO:0030154	cell differentiation

0.68	GO:0046983	protein dimerization activity
0.65	GO:0017162	aryl hydrocarbon receptor binding
0.61	GO:0003700	DNA binding transcription factor activity
0.59	GO:0004874	aryl hydrocarbon receptor activity
0.57	GO:0035326	enhancer binding
0.54	GO:0003713	transcription coactivator activity
0.50	GO:0043565	sequence-specific DNA binding
0.45	GO:0001047	core promoter binding
0.43	GO:0003690	double-stranded DNA binding
0.36	GO:0008234	cysteine-type peptidase activity

0.74	GO:0005667	transcription factor complex
0.61	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.48	GO:0031974	membrane-enclosed lumen
0.47	GO:0034751	aryl hydrocarbon receptor complex
0.44	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

0.36

GO:0008234

sp|P27544|CERS1_HUMAN
Ceramide synthase 1
Search

CERS1

0.96	Cytokine receptor like factor 1

0.50	GO:0046513	ceramide biosynthetic process
0.42	GO:0072721	cellular response to dithiothreitol
0.41	GO:0036146	cellular response to mycotoxin
0.41	GO:0071492	cellular response to UV-A
0.40	GO:0051974	negative regulation of telomerase activity
0.39	GO:0035690	cellular response to drug
0.37	GO:0007420	brain development
0.36	GO:0010469	regulation of receptor activity
0.36	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.36	GO:0060395	SMAD protein signal transduction

0.52	GO:0050291	sphingosine N-acyltransferase activity
0.36	GO:0048018	receptor ligand activity
0.36	GO:0005160	transforming growth factor beta receptor binding
0.32	GO:0005127	ciliary neurotrophic factor receptor binding
0.32	GO:0019955	cytokine binding
0.32	GO:0046982	protein heterodimerization activity

0.45	GO:0005783	endoplasmic reticulum
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0031984	organelle subcompartment
0.35	GO:0005576	extracellular region
0.35	GO:0044431	Golgi apparatus part
0.34	GO:0098588	bounding membrane of organelle
0.31	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

0.52

EC:2.3.1.24

GO:0050291

sp|P27635|RL10_HUMAN
60S ribosomal protein L10
Search

RPL10

0.42	Ribosomal protein 10

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.51	GO:1990403	embryonic brain development
0.49	GO:0000027	ribosomal large subunit assembly
0.48	GO:0007283	spermatogenesis
0.45	GO:0006417	regulation of translation
0.42	GO:0007420	brain development
0.38	GO:0043066	negative regulation of apoptotic process

0.64	GO:0003735	structural constituent of ribosome
0.48	GO:0045182	translation regulator activity
0.41	GO:0003723	RNA binding
0.34	GO:0005515	protein binding
0.33	GO:0005092	GDP-dissociation inhibitor activity
0.32	GO:0016787	hydrolase activity

0.61	GO:0005840	ribosome
0.51	GO:0044445	cytosolic part
0.50	GO:0005783	endoplasmic reticulum
0.47	GO:0005844	polysome
0.44	GO:0044446	intracellular organelle part
0.43	GO:0005634	nucleus
0.35	GO:0043234	protein complex
0.34	GO:0098562	cytoplasmic side of membrane
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.33	GO:0098588	bounding membrane of organelle

0.32

GO:0016787

sp|P27658|CO8A1_HUMAN
Collagen alpha-1(VIII) chain
Search

COL8A1

0.86	Collagen type VIII alpha 1 chain

0.60	GO:0050673	epithelial cell proliferation
0.59	GO:0048593	camera-type eye morphogenesis
0.59	GO:0035987	endodermal cell differentiation
0.54	GO:0010811	positive regulation of cell-substrate adhesion
0.40	GO:0001525	angiogenesis
0.39	GO:0007155	cell adhesion
0.37	GO:0030574	collagen catabolic process
0.36	GO:0030198	extracellular matrix organization
0.36	GO:0014028	notochord formation
0.35	GO:0060322	head development

0.34	GO:0005201	extracellular matrix structural constituent
0.34	GO:0030674	protein binding, bridging

0.77	GO:0005581	collagen trimer
0.64	GO:0005576	extracellular region
0.41	GO:0005938	cell cortex
0.36	GO:0005788	endoplasmic reticulum lumen
0.35	GO:0031982	vesicle
0.34	GO:0099081	supramolecular polymer
0.30	GO:0016020	membrane

sp|P27694|RFA1_HUMAN
Replication protein A 70 kDa DNA-binding subunit
Search

RPA1

0.69	Replication protein A subunit

0.66	GO:0006260	DNA replication
0.65	GO:0006310	DNA recombination
0.64	GO:0006281	DNA repair
0.55	GO:0034502	protein localization to chromosome
0.51	GO:0000723	telomere maintenance
0.42	GO:0048513	animal organ development
0.42	GO:0072359	circulatory system development
0.38	GO:0048873	homeostasis of number of cells within a tissue
0.37	GO:0001701	in utero embryonic development
0.37	GO:0008284	positive regulation of cell proliferation

0.57	GO:0098505	G-rich strand telomeric DNA binding
0.53	GO:0046872	metal ion binding
0.50	GO:0003684	damaged DNA binding
0.37	GO:0003682	chromatin binding
0.33	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.51	GO:0030894	replisome
0.47	GO:0031974	membrane-enclosed lumen
0.44	GO:0043234	protein complex
0.37	GO:0000781	chromosome, telomeric region
0.37	GO:0000793	condensed chromosome

sp|P27695|APEX1_HUMAN
DNA-(apurinic or apyrimidinic site) lyase
Search

APEX1

0.65	DNA-(apurinic or apyrimidinic site) lyase

0.64	GO:0006281	DNA repair
0.64	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.57	GO:0043247	telomere maintenance in response to DNA damage
0.56	GO:0080111	DNA demethylation
0.56	GO:0043488	regulation of mRNA stability
0.51	GO:0042981	regulation of apoptotic process
0.48	GO:0045454	cell redox homeostasis
0.43	GO:2001141	regulation of RNA biosynthetic process
0.42	GO:0014912	negative regulation of smooth muscle cell migration
0.42	GO:0071320	cellular response to cAMP

0.77	GO:0140080	class III/IV DNA-(apurinic or apyrimidinic site) lyase activity
0.77	GO:0140078	class I DNA-(apurinic or apyrimidinic site) lyase activity
0.65	GO:0004519	endonuclease activity
0.59	GO:0008309	double-stranded DNA exodeoxyribonuclease activity
0.56	GO:0003691	double-stranded telomeric DNA binding
0.55	GO:0031490	chromatin DNA binding
0.53	GO:0046872	metal ion binding
0.53	GO:0003713	transcription coactivator activity
0.52	GO:0008408	3'-5' exonuclease activity
0.50	GO:0003684	damaged DNA binding

0.58	GO:0005634	nucleus
0.58	GO:0005739	mitochondrion
0.53	GO:0048471	perinuclear region of cytoplasm
0.52	GO:0005813	centrosome
0.48	GO:0043233	organelle lumen
0.41	GO:0005783	endoplasmic reticulum
0.39	GO:0005667	transcription factor complex
0.35	GO:0000781	chromosome, telomeric region
0.33	GO:0005840	ribosome

0.50

EC:3.1.4

GO:0008081

sp|P27701|CD82_HUMAN
CD82 antigen
Search

CD82

0.60	Tetraspanin

0.42

GO:0007166

cell surface receptor signaling pathway

0.41	GO:0005887	integral component of plasma membrane
0.32	GO:0005634	nucleus

sp|P27707|DCK_HUMAN
Deoxycytidine kinase
Search

DCK

0.60	Deoxynucleoside kinase

0.63	GO:0009165	nucleotide biosynthetic process
0.52	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process
0.51	GO:0016310	phosphorylation
0.48	GO:0006220	pyrimidine nucleotide metabolic process
0.36	GO:0046092	deoxycytidine metabolic process
0.34	GO:0043097	pyrimidine nucleoside salvage
0.34	GO:0046053	dAMP metabolic process
0.34	GO:0072522	purine-containing compound biosynthetic process
0.33	GO:0046385	deoxyribose phosphate biosynthetic process
0.33	GO:0009127	purine nucleoside monophosphate biosynthetic process

0.77	GO:0019206	nucleoside kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0042803	protein homodimerization activity
0.36	GO:0032548	pyrimidine deoxyribonucleoside binding
0.33	GO:0000287	magnesium ion binding
0.32	GO:0046982	protein heterodimerization activity
0.31	GO:0003677	DNA binding

0.45	GO:0005634	nucleus
0.35	GO:0005829	cytosol
0.32	GO:0000786	nucleosome

sp|P27708|PYR1_HUMAN
CAD protein
Search

CAD

0.67	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

0.73	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
0.68	GO:0006541	glutamine metabolic process
0.50	GO:0000050	urea cycle
0.49	GO:0021644	vagus nerve morphogenesis
0.48	GO:0021615	glossopharyngeal nerve morphogenesis
0.48	GO:0021636	trigeminal nerve morphogenesis
0.48	GO:0021610	facial nerve morphogenesis
0.47	GO:1900746	regulation of vascular endothelial growth factor signaling pathway
0.47	GO:0001946	lymphangiogenesis
0.47	GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway

0.77	GO:0004070	aspartate carbamoyltransferase activity
0.75	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
0.74	GO:0016597	amino acid binding
0.74	GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.54	GO:0046872	metal ion binding
0.52	GO:0004087	carbamoyl-phosphate synthase (ammonia) activity

0.55	GO:0016363	nuclear matrix
0.48	GO:0005654	nucleoplasm
0.48	GO:0005829	cytosol
0.39	GO:0043195	terminal bouton
0.38	GO:0043025	neuronal cell body
0.37	GO:0070062	extracellular exosome
0.35	GO:0043234	protein complex
0.33	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

0.77	EC:2.1.3.2	GO:0004070
0.77	KEGG:R01397	GO:0004070

sp|P27797|CALR_HUMAN
Calreticulin
Search

CALR

0.77	Calreticulin like

0.69	GO:0006457	protein folding
0.61	GO:0002502	peptide antigen assembly with MHC class I protein complex
0.60	GO:1901164	negative regulation of trophoblast cell migration
0.59	GO:2000510	positive regulation of dendritic cell chemotaxis
0.59	GO:0048387	negative regulation of retinoic acid receptor signaling pathway
0.58	GO:0090398	cellular senescence
0.57	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
0.57	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway
0.57	GO:0071157	negative regulation of cell cycle arrest
0.57	GO:0050766	positive regulation of phagocytosis

0.71	GO:0051082	unfolded protein binding
0.70	GO:0005509	calcium ion binding
0.58	GO:0050681	androgen receptor binding
0.56	GO:0005178	integrin binding
0.53	GO:0031625	ubiquitin protein ligase binding
0.52	GO:0003729	mRNA binding
0.50	GO:0030246	carbohydrate binding
0.41	GO:0042562	hormone binding
0.40	GO:0042277	peptide binding
0.37	GO:0005506	iron ion binding

0.70	GO:0005783	endoplasmic reticulum
0.55	GO:0005844	polysome
0.54	GO:0009897	external side of plasma membrane
0.54	GO:0048471	perinuclear region of cytoplasm
0.52	GO:0005635	nuclear envelope
0.51	GO:0005615	extracellular space
0.50	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.49	GO:0070013	intracellular organelle lumen
0.48	GO:0005829	cytosol
0.48	GO:0031984	organelle subcompartment

sp|P27815|PDE4A_HUMAN
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Search

PDE4A

0.56	Phosphodiesterase

0.61	GO:0007165	signal transduction
0.58	GO:0006198	cAMP catabolic process
0.55	GO:0035690	cellular response to drug
0.54	GO:0043949	regulation of cAMP-mediated signaling
0.53	GO:0010738	regulation of protein kinase A signaling
0.49	GO:0007608	sensory perception of smell
0.47	GO:0001780	neutrophil homeostasis
0.47	GO:0032743	positive regulation of interleukin-2 production
0.47	GO:0032729	positive regulation of interferon-gamma production
0.46	GO:0030593	neutrophil chemotaxis

0.80	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.58	GO:0030552	cAMP binding
0.54	GO:0046872	metal ion binding
0.45	GO:0043015	gamma-tubulin binding
0.34	GO:0044325	ion channel binding
0.34	GO:0019901	protein kinase binding

0.50	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0005829	cytosol
0.47	GO:0060076	excitatory synapse
0.46	GO:0005654	nucleoplasm
0.46	GO:0043197	dendritic spine
0.45	GO:0014069	postsynaptic density
0.45	GO:0000930	gamma-tubulin complex
0.45	GO:0008021	synaptic vesicle
0.44	GO:0005813	centrosome
0.42	GO:0071944	cell periphery

0.80

EC:3.1.4.17

GO:0004114

sp|P27816|MAP4_HUMAN
Microtubule-associated protein 4
Search

MAP4

0.53	Microtubule-associated protein 4

0.86	GO:1902856	negative regulation of non-motile cilium assembly
0.85	GO:0051012	microtubule sliding
0.80	GO:0051294	establishment of spindle orientation
0.78	GO:0007052	mitotic spindle organization
0.75	GO:0031175	neuron projection development
0.63	GO:0051301	cell division

0.71	GO:0008017	microtubule binding
0.46	GO:0003723	RNA binding
0.41	GO:0005198	structural molecule activity

0.78	GO:0014069	postsynaptic density
0.77	GO:0005930	axoneme
0.76	GO:0072686	mitotic spindle
0.74	GO:0043005	neuron projection
0.73	GO:0005875	microtubule associated complex
0.70	GO:0005874	microtubule
0.63	GO:0005829	cytosol
0.59	GO:0070062	extracellular exosome
0.52	GO:0005886	plasma membrane

sp|P27824|CALX_HUMAN
Calnexin
Search

CANX

0.86

Calnexin

0.69	GO:0006457	protein folding
0.57	GO:0048488	synaptic vesicle endocytosis
0.50	GO:0072583	clathrin-dependent endocytosis
0.42	GO:0048916	posterior lateral line development
0.39	GO:0007568	aging
0.36	GO:0070757	interleukin-35-mediated signaling pathway
0.36	GO:0070106	interleukin-27-mediated signaling pathway
0.35	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.35	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
0.34	GO:0009306	protein secretion

0.71	GO:0051082	unfolded protein binding
0.70	GO:0005509	calcium ion binding
0.40	GO:0034185	apolipoprotein binding
0.40	GO:0035255	ionotropic glutamate receptor binding
0.38	GO:0030246	carbohydrate binding
0.34	GO:0003723	RNA binding
0.33	GO:0005198	structural molecule activity

0.70	GO:0005783	endoplasmic reticulum
0.54	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.54	GO:0044233	ER-mitochondrion membrane contact site
0.54	GO:0043209	myelin sheath
0.52	GO:0031984	organelle subcompartment
0.51	GO:0045202	synapse
0.40	GO:0042470	melanosome
0.40	GO:0032839	dendrite cytoplasm
0.39	GO:0044309	neuron spine
0.39	GO:0043025	neuronal cell body

sp|P27918|PROP_HUMAN
Properdin
Search

CFP

0.76	Complement factor properdin

0.58	GO:0048036	central complex development
0.55	GO:0042048	olfactory behavior
0.55	GO:0001700	embryonic development via the syncytial blastoderm
0.53	GO:0006508	proteolysis
0.48	GO:0006957	complement activation, alternative pathway
0.44	GO:0007229	integrin-mediated signaling pathway
0.43	GO:0099643	signal release from synapse
0.43	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.42	GO:0006836	neurotransmitter transport
0.41	GO:0010466	negative regulation of peptidase activity

0.57	GO:0008237	metallopeptidase activity
0.52	GO:0002020	protease binding
0.50	GO:0004175	endopeptidase activity
0.48	GO:0046872	metal ion binding
0.41	GO:0030414	peptidase inhibitor activity
0.40	GO:0061135	endopeptidase regulator activity
0.35	GO:0070001	aspartic-type peptidase activity
0.33	GO:0003677	DNA binding

0.58	GO:0005576	extracellular region
0.49	GO:0016607	nuclear speck
0.43	GO:0008021	synaptic vesicle
0.30	GO:0016020	membrane
0.30	GO:0070820	tertiary granule
0.30	GO:0035580	specific granule lumen
0.30	GO:0044432	endoplasmic reticulum part

sp|P27930|IL1R2_HUMAN
Interleukin-1 receptor type 2
Search

IL1R2

0.97	Interleukin-1 receptor type II

0.79	GO:0019221	cytokine-mediated signaling pathway
0.71	GO:0032690	negative regulation of interleukin-1 alpha production
0.70	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway
0.69	GO:0050705	regulation of interleukin-1 alpha secretion
0.68	GO:0050711	negative regulation of interleukin-1 secretion
0.68	GO:1900016	negative regulation of cytokine production involved in inflammatory response
0.65	GO:0010955	negative regulation of protein processing
0.39	GO:0071347	cellular response to interleukin-1
0.37	GO:0006955	immune response

0.87	GO:0004910	interleukin-1, Type II, blocking receptor activity
0.68	GO:0019966	interleukin-1 binding

0.42	GO:0005737	cytoplasm
0.40	GO:0005576	extracellular region
0.37	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P27986|P85A_HUMAN
Phosphatidylinositol 3-kinase regulatory subunit alpha
Search

PIK3R1

0.92	Phosphatidylinositol 3-kinase regulatory subunit alpha

0.85	GO:0043551	regulation of phosphatidylinositol 3-kinase activity
0.58	GO:1900076	regulation of cellular response to insulin stimulus
0.57	GO:0007165	signal transduction
0.57	GO:0051531	NFAT protein import into nucleus
0.57	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response
0.56	GO:0046326	positive regulation of glucose import
0.55	GO:0033120	positive regulation of RNA splicing
0.55	GO:0042993	positive regulation of transcription factor import into nucleus
0.55	GO:0032869	cellular response to insulin stimulus
0.55	GO:0071378	cellular response to growth hormone stimulus

0.85	GO:0035014	phosphatidylinositol 3-kinase regulator activity
0.58	GO:0043125	ErbB-3 class receptor binding
0.57	GO:0043559	insulin binding
0.57	GO:0005168	neurotrophin TRKA receptor binding
0.55	GO:0005159	insulin-like growth factor receptor binding
0.55	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding
0.55	GO:0005158	insulin receptor binding
0.54	GO:0043560	insulin receptor substrate binding
0.54	GO:0001784	phosphotyrosine residue binding
0.53	GO:0016301	kinase activity

0.83	GO:0005942	phosphatidylinositol 3-kinase complex
0.56	GO:1990578	perinuclear endoplasmic reticulum membrane
0.51	GO:0005801	cis-Golgi network
0.49	GO:0005911	cell-cell junction
0.46	GO:0005829	cytosol
0.43	GO:0005634	nucleus
0.42	GO:0043234	protein complex
0.34	GO:0043005	neuron projection
0.33	GO:0005886	plasma membrane

0.35

GO:0016773

sp|P27987|IP3KB_HUMAN
Inositol-trisphosphate 3-kinase B
Search

ITPKB

0.64	Inositol-trisphosphate 3-kinase B

0.86	GO:0033030	negative regulation of neutrophil apoptotic process
0.85	GO:0035726	common myeloid progenitor cell proliferation
0.84	GO:0045059	positive thymic T cell selection
0.83	GO:0032958	inositol phosphate biosynthetic process
0.81	GO:0046638	positive regulation of alpha-beta T cell differentiation
0.80	GO:0032957	inositol trisphosphate metabolic process
0.80	GO:0071277	cellular response to calcium ion
0.80	GO:0045638	negative regulation of myeloid cell differentiation
0.79	GO:0046579	positive regulation of Ras protein signal transduction
0.78	GO:0002262	myeloid cell homeostasis

0.85	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity
0.74	GO:0005516	calmodulin binding
0.52	GO:0032559	adenyl ribonucleotide binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding

0.64	GO:0005829	cytosol
0.58	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.85	EC:2.7.1.127	GO:0008440
0.85	KEGG:R03433	GO:0008440

sp|P28039|AOAH_HUMAN
Acyloxyacyl hydrolase
Search

AOAH

0.93	Acyloxyacyl hydrolase

0.54	GO:0050728	negative regulation of inflammatory response
0.49	GO:0008653	lipopolysaccharide metabolic process
0.36	GO:0006643	membrane lipid metabolic process
0.36	GO:0006954	inflammatory response
0.34	GO:0006497	protein lipidation
0.34	GO:0006661	phosphatidylinositol biosynthetic process
0.33	GO:1901137	carbohydrate derivative biosynthetic process

0.61

GO:0016788

hydrolase activity, acting on ester bonds

0.38	GO:0031410	cytoplasmic vesicle
0.37	GO:0005576	extracellular region
0.35	GO:0005764	lysosome
0.30	GO:0016020	membrane

0.61

EC:3.1

GO:0016788

sp|P28062|PSB8_HUMAN
Proteasome subunit beta type-8
Search

PSMB8

0.53	Proteasome subunit beta type

0.71	GO:0051603	proteolysis involved in cellular protein catabolic process
0.54	GO:0045444	fat cell differentiation
0.49	GO:0019882	antigen processing and presentation
0.49	GO:0052548	regulation of endopeptidase activity
0.36	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.36	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.36	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.36	GO:0060337	type I interferon signaling pathway
0.36	GO:0038095	Fc-epsilon receptor signaling pathway
0.36	GO:1902036	regulation of hematopoietic stem cell differentiation

0.77	GO:0070003	threonine-type peptidase activity
0.64	GO:0004175	endopeptidase activity
0.33	GO:0005515	protein binding

0.75	GO:0005839	proteasome core complex
0.60	GO:0005634	nucleus
0.56	GO:1990111	spermatoproteasome complex
0.48	GO:0005737	cytoplasm
0.36	GO:0070062	extracellular exosome
0.35	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part

sp|P28065|PSB9_HUMAN
Proteasome subunit beta type-9
Search

PSMB9

0.53	Proteasome subunit beta type

0.72	GO:0051603	proteolysis involved in cellular protein catabolic process
0.67	GO:0002376	immune system process
0.55	GO:2000116	regulation of cysteine-type endopeptidase activity
0.48	GO:0043632	modification-dependent macromolecule catabolic process
0.37	GO:0071347	cellular response to interleukin-1
0.36	GO:1901423	response to benzene
0.36	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.36	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:1902036	regulation of hematopoietic stem cell differentiation

0.77	GO:0004298	threonine-type endopeptidase activity
0.35	GO:0070628	proteasome binding

0.76	GO:0005839	proteasome core complex
0.59	GO:0005634	nucleus
0.49	GO:0005829	cytosol
0.44	GO:1990111	spermatoproteasome complex
0.36	GO:0070062	extracellular exosome
0.35	GO:0070013	intracellular organelle lumen
0.34	GO:0044446	intracellular organelle part

0.77

GO:0004298

sp|P28066|PSA5_HUMAN
Proteasome subunit alpha type-5
Search

PSMA5

0.48	Proteasome endopeptidase complex

0.76	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.35	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.35	GO:0045595	regulation of cell differentiation
0.35	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.35	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
0.35	GO:0051005	negative regulation of lipoprotein lipase activity
0.35	GO:0071310	cellular response to organic substance

0.77	GO:0004298	threonine-type endopeptidase activity
0.35	GO:0030379	neurotensin receptor activity, non-G-protein coupled
0.35	GO:0010465	nerve growth factor receptor activity
0.35	GO:0048406	nerve growth factor binding
0.33	GO:0019899	enzyme binding

0.79	GO:0019773	proteasome core complex, alpha-subunit complex
0.58	GO:0005634	nucleus
0.49	GO:0005737	cytoplasm
0.37	GO:0070062	extracellular exosome
0.35	GO:0012505	endomembrane system
0.35	GO:0031983	vesicle lumen
0.35	GO:0097708	intracellular vesicle
0.34	GO:0070013	intracellular organelle lumen
0.34	GO:0044446	intracellular organelle part
0.34	GO:0098589	membrane region

0.77

GO:0004298

sp|P28067|DMA_HUMAN
HLA class II histocompatibility antigen, DM alpha chain
Search

HLA-DMA

0.65	Histocompatibility antigen DM heterodimer heavy chain

0.79	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
0.73	GO:0006955	immune response
0.56	GO:0002399	MHC class II protein complex assembly
0.56	GO:0002501	peptide antigen assembly with MHC protein complex
0.38	GO:0002478	antigen processing and presentation of exogenous peptide antigen
0.36	GO:0002636	positive regulation of germinal center formation
0.36	GO:0045059	positive thymic T cell selection
0.35	GO:0002922	positive regulation of humoral immune response
0.35	GO:0045582	positive regulation of T cell differentiation
0.35	GO:0002449	lymphocyte mediated immunity

0.56	GO:0023026	MHC class II protein complex binding
0.36	GO:0032395	MHC class II receptor activity

0.75	GO:0042613	MHC class II protein complex
0.49	GO:0009986	cell surface
0.41	GO:0043227	membrane-bounded organelle
0.40	GO:0043229	intracellular organelle
0.37	GO:0043230	extracellular organelle
0.36	GO:0005615	extracellular space
0.36	GO:0098805	whole membrane
0.36	GO:0005581	collagen trimer
0.35	GO:0012505	endomembrane system
0.34	GO:0044422	organelle part

sp|P28068|DMB_HUMAN
HLA class II histocompatibility antigen, DM beta chain
Search

0.40	Histocompatibility antigen DM heterodimer light chain

0.77	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
0.72	GO:0006955	immune response
0.52	GO:0002478	antigen processing and presentation of exogenous peptide antigen
0.49	GO:0051085	chaperone cofactor-dependent protein refolding
0.41	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
0.40	GO:0002399	MHC class II protein complex assembly
0.40	GO:0002501	peptide antigen assembly with MHC protein complex
0.39	GO:0050671	positive regulation of lymphocyte proliferation
0.38	GO:0042129	regulation of T cell proliferation
0.33	GO:0016446	somatic hypermutation of immunoglobulin genes

0.53	GO:0023026	MHC class II protein complex binding
0.34	GO:0003823	antigen binding
0.32	GO:0034987	immunoglobulin receptor binding
0.32	GO:0042802	identical protein binding

0.74	GO:0042613	MHC class II protein complex
0.50	GO:0005771	multivesicular body
0.49	GO:0005765	lysosomal membrane
0.48	GO:0010008	endosome membrane
0.34	GO:0005581	collagen trimer
0.33	GO:0019815	B cell receptor complex
0.32	GO:0009897	external side of plasma membrane
0.32	GO:0042571	immunoglobulin complex, circulating
0.32	GO:0072562	blood microparticle
0.30	GO:0016021	integral component of membrane

sp|P28069|PIT1_HUMAN
Pituitary-specific positive transcription factor 1
Search

POU1F1

0.60	Pituitary-specific positive transcription factor 1

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:0006351	transcription, DNA-templated
0.56	GO:0010468	regulation of gene expression
0.54	GO:0060133	somatotropin secreting cell development
0.54	GO:0032962	positive regulation of inositol trisphosphate biosynthetic process
0.53	GO:0001708	cell fate specification
0.52	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway
0.51	GO:0040018	positive regulation of multicellular organism growth
0.51	GO:0051254	positive regulation of RNA metabolic process

0.63	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.51	GO:0001105	RNA polymerase II transcription coactivator activity
0.51	GO:0001102	RNA polymerase II activating transcription factor binding
0.48	GO:0003682	chromatin binding
0.41	GO:0003714	transcription corepressor activity
0.41	GO:0044212	transcription regulatory region DNA binding
0.40	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.47	GO:0005667	transcription factor complex
0.30	GO:0016020	membrane

sp|P28070|PSB4_HUMAN
Proteasome subunit beta type-4
Search

PSMB4

0.51	Proteasome subunit beta type

0.71	GO:0051603	proteolysis involved in cellular protein catabolic process
0.59	GO:0002862	negative regulation of inflammatory response to antigenic stimulus
0.36	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.36	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.36	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.36	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.35	GO:0038095	Fc-epsilon receptor signaling pathway
0.35	GO:1902036	regulation of hematopoietic stem cell differentiation
0.35	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
0.35	GO:0070498	interleukin-1-mediated signaling pathway

0.76	GO:0070003	threonine-type peptidase activity
0.64	GO:0004175	endopeptidase activity
0.55	GO:0001530	lipopolysaccharide binding
0.33	GO:0005515	protein binding
0.32	GO:0003677	DNA binding

0.75	GO:0005839	proteasome core complex
0.60	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.36	GO:0070062	extracellular exosome
0.35	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part
0.30	GO:0044425	membrane part

sp|P28072|PSB6_HUMAN
Proteasome subunit beta type-6
Search

PSMB6

0.53	Proteasome subunit beta type

0.72	GO:0051603	proteolysis involved in cellular protein catabolic process
0.53	GO:0043632	modification-dependent macromolecule catabolic process
0.36	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.36	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.36	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.36	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.36	GO:0038095	Fc-epsilon receptor signaling pathway
0.36	GO:1902036	regulation of hematopoietic stem cell differentiation
0.36	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
0.35	GO:0070498	interleukin-1-mediated signaling pathway

0.77	GO:0070003	threonine-type peptidase activity
0.65	GO:0004175	endopeptidase activity
0.51	GO:0045296	cadherin binding

0.76	GO:0005839	proteasome core complex
0.60	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.45	GO:0031974	membrane-enclosed lumen
0.41	GO:0044446	intracellular organelle part
0.36	GO:0070062	extracellular exosome

sp|P28074|PSB5_HUMAN
Proteasome subunit beta type-5
Search

PSMB5

0.53	Proteasome subunit beta type

0.73	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.48	GO:0006979	response to oxidative stress
0.40	GO:0080129	proteasome core complex assembly
0.39	GO:0010499	proteasomal ubiquitin-independent protein catabolic process
0.36	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.36	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.36	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.36	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.36	GO:0038095	Fc-epsilon receptor signaling pathway
0.36	GO:1902036	regulation of hematopoietic stem cell differentiation

0.76	GO:0070003	threonine-type peptidase activity
0.64	GO:0004175	endopeptidase activity
0.33	GO:0005515	protein binding

0.75	GO:0005839	proteasome core complex
0.60	GO:0005634	nucleus
0.51	GO:0005813	centrosome
0.48	GO:0005737	cytoplasm
0.46	GO:0031974	membrane-enclosed lumen
0.36	GO:0070062	extracellular exosome

sp|P28161|GSTM2_HUMAN
Glutathione S-transferase Mu 2
Search

0.43	Glutathione S-transferase

0.53	GO:0018916	nitrobenzene metabolic process
0.50	GO:0006749	glutathione metabolic process
0.48	GO:0042178	xenobiotic catabolic process
0.48	GO:0070458	cellular detoxification of nitrogen compound
0.42	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
0.42	GO:0071313	cellular response to caffeine
0.42	GO:0043651	linoleic acid metabolic process
0.42	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
0.42	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
0.41	GO:1901685	glutathione derivative metabolic process

0.78	GO:0004364	glutathione transferase activity
0.51	GO:0043295	glutathione binding
0.48	GO:0042802	identical protein binding
0.45	GO:0019899	enzyme binding
0.44	GO:0046983	protein dimerization activity
0.40	GO:0004602	glutathione peroxidase activity
0.38	GO:0005102	receptor binding
0.34	GO:0005496	steroid binding
0.34	GO:0016151	nickel cation binding

0.55	GO:0045171	intercellular bridge
0.48	GO:0005829	cytosol
0.41	GO:0016529	sarcoplasmic reticulum
0.35	GO:0070062	extracellular exosome
0.34	GO:0043209	myelin sheath
0.33	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

0.78

EC:2.5.1.18

GO:0004364

sp|P28221|5HT1D_HUMAN
5-hydroxytryptamine receptor 1D
Search

HTR1D

0.97	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled

0.85	GO:0042310	vasoconstriction
0.85	GO:0098664	G-protein coupled serotonin receptor signaling pathway
0.84	GO:0050795	regulation of behavior
0.78	GO:0007268	chemical synaptic transmission
0.76	GO:0006939	smooth muscle contraction
0.69	GO:0040012	regulation of locomotion
0.63	GO:0046849	bone remodeling
0.62	GO:0007631	feeding behavior
0.62	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.50	GO:0014063	negative regulation of serotonin secretion

0.85	GO:0099589	serotonin receptor activity
0.82	GO:0099528	G-protein coupled neurotransmitter receptor activity
0.82	GO:0008227	G-protein coupled amine receptor activity
0.61	GO:0051378	serotonin binding
0.37	GO:0008144	drug binding
0.33	GO:0005515	protein binding

0.67	GO:0005887	integral component of plasma membrane
0.36	GO:0005737	cytoplasm

sp|P28222|5HT1B_HUMAN
5-hydroxytryptamine receptor 1B
Search

HTR1B

0.97	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

0.81	GO:0046849	bone remodeling
0.80	GO:0042310	vasoconstriction
0.80	GO:0098664	G-protein coupled serotonin receptor signaling pathway
0.79	GO:0050795	regulation of behavior
0.78	GO:0007631	feeding behavior
0.73	GO:0007268	chemical synaptic transmission
0.63	GO:0014063	negative regulation of serotonin secretion
0.61	GO:0071312	cellular response to alkaloid
0.59	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.59	GO:0071502	cellular response to temperature stimulus

0.80	GO:0099589	serotonin receptor activity
0.77	GO:0099528	G-protein coupled neurotransmitter receptor activity
0.77	GO:0008227	G-protein coupled amine receptor activity
0.58	GO:0051378	serotonin binding
0.41	GO:0008144	drug binding
0.33	GO:0005515	protein binding

0.63	GO:0005887	integral component of plasma membrane
0.39	GO:0005737	cytoplasm

sp|P28223|5HT2A_HUMAN
5-hydroxytryptamine receptor 2A
Search

HTR2A

0.97	5-hydroxytryptamine (Serotonin) receptor 2 A

0.81	GO:0006939	smooth muscle contraction
0.81	GO:0098664	G-protein coupled serotonin receptor signaling pathway
0.80	GO:0050795	regulation of behavior
0.78	GO:0046883	regulation of hormone secretion
0.60	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process
0.59	GO:0007202	activation of phospholipase C activity
0.58	GO:0051209	release of sequestered calcium ion into cytosol
0.58	GO:0014065	phosphatidylinositol 3-kinase signaling
0.57	GO:0045821	positive regulation of glycolytic process
0.56	GO:0070374	positive regulation of ERK1 and ERK2 cascade

0.81	GO:0099589	serotonin receptor activity
0.78	GO:0099528	G-protein coupled neurotransmitter receptor activity
0.78	GO:0008227	G-protein coupled amine receptor activity
0.61	GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
0.60	GO:0051378	serotonin binding
0.41	GO:0001965	G-protein alpha-subunit binding
0.38	GO:0032403	protein complex binding
0.36	GO:0018738	S-formylglutathione hydrolase activity
0.36	GO:0104005	hijacked molecular function

0.83	GO:0043198	dendritic shaft
0.64	GO:0005887	integral component of plasma membrane
0.45	GO:0005901	caveola
0.44	GO:0030424	axon
0.42	GO:0031410	cytoplasmic vesicle
0.42	GO:0070852	cell body fiber
0.39	GO:0043025	neuronal cell body
0.37	GO:0005829	cytosol

0.36	EC:3.1.2.12	GO:0018738
0.36	KEGG:R00527	GO:0018738

sp|P28288|ABCD3_HUMAN
ATP-binding cassette sub-family D member 3
Search

ABCD3

0.96	LOW QUALITY PROTEIN: ATP-binding cassette sub-family D member 3

0.85	GO:0015910	peroxisomal long-chain fatty acid import
0.56	GO:0042760	very long-chain fatty acid catabolic process
0.54	GO:0055085	transmembrane transport
0.52	GO:0007031	peroxisome organization
0.51	GO:0006635	fatty acid beta-oxidation
0.47	GO:0006633	fatty acid biosynthetic process
0.37	GO:0014070	response to organic cyclic compound
0.36	GO:0042493	response to drug

0.83	GO:0005324	long-chain fatty acid transporter activity
0.73	GO:0042803	protein homodimerization activity
0.64	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0043621	protein self-association
0.33	GO:0005198	structural molecule activity

0.74	GO:0005777	peroxisome
0.54	GO:0031907	microbody lumen
0.51	GO:0031903	microbody membrane
0.44	GO:0031966	mitochondrial membrane
0.44	GO:0019866	organelle inner membrane
0.34	GO:0005829	cytosol
0.33	GO:0019028	viral capsid
0.30	GO:0016021	integral component of membrane

sp|P28289|TMOD1_HUMAN
Tropomodulin-1
Search

TMOD1

0.89	Erythrocyte tropomodulin

0.85	GO:0051694	pointed-end actin filament capping
0.58	GO:0070307	lens fiber cell development
0.58	GO:0030239	myofibril assembly
0.57	GO:0006936	muscle contraction
0.55	GO:0008344	adult locomotory behavior
0.44	GO:0007015	actin filament organization
0.36	GO:0033275	actin-myosin filament sliding
0.35	GO:0031034	myosin filament assembly
0.35	GO:0045292	mRNA cis splicing, via spliceosome
0.34	GO:0048821	erythrocyte development

0.85	GO:0005523	tropomyosin binding
0.78	GO:0051015	actin filament binding
0.35	GO:0000339	RNA cap binding
0.32	GO:0046872	metal ion binding

0.57	GO:0005865	striated muscle thin filament
0.55	GO:0005884	actin filament
0.54	GO:0008180	COP9 signalosome
0.53	GO:0030863	cortical cytoskeleton
0.38	GO:0043034	costamere
0.38	GO:0042383	sarcolemma
0.36	GO:0098723	skeletal muscle myofibril
0.35	GO:0005846	nuclear cap binding complex
0.34	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

sp|P28290|SSFA2_HUMAN
Sperm-specific antigen 2
Search

SSFA2

0.97	Sperm-specific antigen 2

0.73	GO:0003779	actin binding
0.70	GO:0005102	receptor binding
0.53	GO:0032403	protein complex binding

0.55	GO:0005886	plasma membrane
0.50	GO:0005829	cytosol
0.46	GO:0005634	nucleus
0.30	GO:0044425	membrane part

sp|P28300|LYOX_HUMAN
Protein-lysine 6-oxidase
Search

LOX

0.86	Lysyl oxidase a

0.57	GO:0048251	elastic fiber assembly
0.56	GO:0035904	aorta development
0.56	GO:0030199	collagen fibril organization
0.54	GO:0030324	lung development
0.54	GO:0048514	blood vessel morphogenesis
0.53	GO:0055114	oxidation-reduction process
0.53	GO:0007507	heart development
0.42	GO:0051216	cartilage development
0.42	GO:0007517	muscle organ development
0.41	GO:0042060	wound healing

0.77	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
0.72	GO:0005507	copper ion binding
0.43	GO:0140096	catalytic activity, acting on a protein
0.35	GO:0005515	protein binding
0.34	GO:0035091	phosphatidylinositol binding

0.52	GO:0005581	collagen trimer
0.51	GO:0005578	proteinaceous extracellular matrix
0.51	GO:0005615	extracellular space
0.37	GO:0005634	nucleus

0.77

EC:1.4.3

GO:0016641

sp|P28324|ELK4_HUMAN
ETS domain-containing protein Elk-4
Search

ELK4

0.97	ETS domain-containing protein Elk-4

0.60	GO:0070932	histone H3 deacetylation
0.57	GO:0000122	negative regulation of transcription by RNA polymerase II
0.56	GO:0045944	positive regulation of transcription by RNA polymerase II
0.45	GO:0030154	cell differentiation
0.38	GO:0006366	transcription by RNA polymerase II
0.36	GO:0001525	angiogenesis
0.36	GO:0042060	wound healing

0.63	GO:0043565	sequence-specific DNA binding
0.60	GO:0003700	DNA binding transcription factor activity
0.58	GO:0001012	RNA polymerase II regulatory region DNA binding
0.57	GO:0003682	chromatin binding
0.54	GO:0003690	double-stranded DNA binding
0.38	GO:0003712	transcription cofactor activity
0.36	GO:0001047	core promoter binding
0.34	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.52	GO:0005829	cytosol
0.52	GO:0031974	membrane-enclosed lumen
0.46	GO:0044446	intracellular organelle part
0.34	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

sp|P28325|CYTD_HUMAN
Cystatin-D
Search

0.76	Cystatin-SA

0.76	GO:0010951	negative regulation of endopeptidase activity
0.56	GO:0010711	negative regulation of collagen catabolic process
0.56	GO:2000116	regulation of cysteine-type endopeptidase activity
0.56	GO:0060311	negative regulation of elastin catabolic process
0.54	GO:0060313	negative regulation of blood vessel remodeling
0.54	GO:0010716	negative regulation of extracellular matrix disassembly
0.47	GO:0097435	supramolecular fiber organization
0.46	GO:0006952	defense response
0.45	GO:0042747	circadian sleep/wake cycle, REM sleep
0.44	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste

0.83	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.62	GO:0002020	protease binding
0.52	GO:0001540	amyloid-beta binding
0.47	GO:0042802	identical protein binding

0.56	GO:0005615	extracellular space
0.43	GO:1903561	extracellular vesicle
0.42	GO:0005771	multivesicular body
0.41	GO:0005604	basement membrane
0.41	GO:0043025	neuronal cell body
0.41	GO:0043292	contractile fiber
0.41	GO:0030424	axon
0.41	GO:0031965	nuclear membrane
0.41	GO:0048471	perinuclear region of cytoplasm
0.41	GO:0005764	lysosome

sp|P28328|PEX2_HUMAN
Peroxisome biogenesis factor 2
Search

PEX2

0.83	Peroxisomal biogenesis factor 2

0.59	GO:0048147	negative regulation of fibroblast proliferation
0.58	GO:0031648	protein destabilization
0.57	GO:0050680	negative regulation of epithelial cell proliferation
0.57	GO:0000038	very long-chain fatty acid metabolic process
0.56	GO:0016558	protein import into peroxisome matrix
0.54	GO:0000122	negative regulation of transcription by RNA polymerase II
0.53	GO:0006635	fatty acid beta-oxidation
0.38	GO:0045540	regulation of cholesterol biosynthetic process
0.38	GO:0006699	bile acid biosynthetic process
0.37	GO:0042632	cholesterol homeostasis

0.53	GO:0046872	metal ion binding
0.38	GO:0061630	ubiquitin protein ligase activity
0.35	GO:0016874	ligase activity
0.33	GO:0005515	protein binding

0.55	GO:0016593	Cdc73/Paf1 complex
0.55	GO:0005779	integral component of peroxisomal membrane

0.35

EC:6

GO:0016874

sp|P28329|CLAT_HUMAN
Choline O-acetyltransferase
Search

CHAT

0.96	Choline O-acetyltransferase a

0.55	GO:0060416	response to growth hormone
0.43	GO:0007626	locomotory behavior
0.40	GO:0042136	neurotransmitter biosynthetic process
0.38	GO:0007529	establishment of synaptic specificity at neuromuscular junction
0.38	GO:0043179	rhythmic excitation
0.38	GO:0007268	chemical synaptic transmission
0.37	GO:0007622	rhythmic behavior
0.37	GO:0016358	dendrite development
0.37	GO:0030534	adult behavior
0.36	GO:0007517	muscle organ development

0.62	GO:0016746	transferase activity, transferring acyl groups
0.35	GO:0033265	choline binding

0.37	GO:0097458	neuron part
0.36	GO:0044297	cell body
0.36	GO:0120025	plasma membrane bounded cell projection
0.35	GO:0044456	synapse part
0.34	GO:0043231	intracellular membrane-bounded organelle
0.34	GO:0044444	cytoplasmic part

0.62

GO:0016746

sp|P28330|ACADL_HUMAN
Long-chain specific acyl-CoA dehydrogenase, mitochondrial
Search

ACADL

0.96	Acyl-CoA dehydrogenase long chain

0.85	GO:0042758	long-chain fatty acid catabolic process
0.53	GO:0055114	oxidation-reduction process

0.86	GO:0004466	long-chain-acyl-CoA dehydrogenase activity
0.66	GO:0050660	flavin adenine dinucleotide binding

0.30

GO:0031224

intrinsic component of membrane

0.86

EC:1.3.99.13

GO:0004466

sp|P28331|NDUS1_HUMAN
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Search

NDUFS1

0.90	NADH:ubiquinone oxidoreductase core subunit S1

0.75	GO:0008637	apoptotic mitochondrial changes
0.71	GO:0051881	regulation of mitochondrial membrane potential
0.69	GO:0042773	ATP synthesis coupled electron transport
0.62	GO:0072593	reactive oxygen species metabolic process

0.69	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.64	GO:0051536	iron-sulfur cluster binding
0.60	GO:0009055	electron transfer activity
0.34	GO:0046872	metal ion binding

0.71	GO:0005747	mitochondrial respiratory chain complex I
0.69	GO:0043209	myelin sheath
0.67	GO:0005758	mitochondrial intermembrane space
0.59	GO:0045272	plasma membrane respiratory chain complex I

0.69

EC:1.6.5.3

GO:0008137

sp|P28332|ADH6_HUMAN
Alcohol dehydrogenase 6
Search

0.72	Alcohol dehydrogenase class VII

0.52	GO:0055114	oxidation-reduction process
0.48	GO:0006067	ethanol metabolic process
0.43	GO:0045471	response to ethanol
0.42	GO:0042573	retinoic acid metabolic process
0.41	GO:0042572	retinol metabolic process
0.41	GO:0034310	primary alcohol catabolic process
0.39	GO:0033574	response to testosterone
0.38	GO:1900116	extracellular negative regulation of signal transduction
0.38	GO:0042737	drug catabolic process
0.38	GO:0032526	response to retinoic acid

0.61	GO:0008270	zinc ion binding
0.53	GO:0004022	alcohol dehydrogenase (NAD) activity
0.47	GO:0035276	ethanol binding
0.41	GO:0004745	retinol dehydrogenase activity
0.39	GO:0004031	aldehyde oxidase activity
0.39	GO:0019841	retinol binding
0.38	GO:0048019	receptor antagonist activity
0.37	GO:0042803	protein homodimerization activity
0.36	GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase activity
0.35	GO:0051287	NAD binding

0.40	GO:0005829	cytosol
0.37	GO:0005654	nucleoplasm
0.37	GO:0005576	extracellular region
0.36	GO:0031982	vesicle
0.36	GO:0005886	plasma membrane
0.35	GO:0005739	mitochondrion

0.53	EC:1.1.1.1	GO:0004022
0.36	KEGG:R06983 KEGG:R07140	GO:0051903

sp|P28335|5HT2C_HUMAN
5-hydroxytryptamine receptor 2C
Search

HTR2C

0.97	5-hydroxytryptamine (Serotonin) receptor 2C long isoform

0.79	GO:0098664	G-protein coupled serotonin receptor signaling pathway
0.78	GO:0007631	feeding behavior
0.76	GO:0007626	locomotory behavior
0.63	GO:0043397	regulation of corticotropin-releasing hormone secretion
0.62	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process
0.61	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
0.60	GO:0001662	behavioral fear response
0.60	GO:0032098	regulation of appetite
0.60	GO:0051209	release of sequestered calcium ion into cytosol
0.60	GO:0031644	regulation of neurological system process

0.79	GO:0099589	serotonin receptor activity
0.76	GO:0099528	G-protein coupled neurotransmitter receptor activity
0.76	GO:0008227	G-protein coupled amine receptor activity
0.64	GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
0.62	GO:0051378	serotonin binding
0.33	GO:0005515	protein binding

0.63	GO:0005887	integral component of plasma membrane
0.37	GO:0009897	external side of plasma membrane
0.32	GO:0005622	intracellular

sp|P28336|NMBR_HUMAN
Neuromedin-B receptor
Search

NMBR

0.97	Neuromedin-B receptor

0.77	GO:0031989	bombesin receptor signaling pathway
0.49	GO:0036343	psychomotor behavior
0.47	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
0.47	GO:0035176	social behavior
0.46	GO:0007218	neuropeptide signaling pathway
0.44	GO:0042127	regulation of cell proliferation
0.42	GO:0043207	response to external biotic stimulus

0.79	GO:0008528	G-protein coupled peptide receptor activity
0.32	GO:0005515	protein binding

0.48	GO:0005829	cytosol
0.45	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

sp|P28340|DPOD1_HUMAN
DNA polymerase delta catalytic subunit
Search

POLD1

0.47	DNA polymerase delta catalytic subunit

0.67	GO:0071897	DNA biosynthetic process
0.66	GO:0006260	DNA replication
0.64	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.57	GO:0006287	base-excision repair, gap-filling
0.49	GO:0006297	nucleotide-excision repair, DNA gap filling
0.42	GO:0055089	fatty acid homeostasis
0.41	GO:0034644	cellular response to UV
0.36	GO:0042769	DNA damage response, detection of DNA damage
0.35	GO:0006301	postreplication repair
0.35	GO:0006283	transcription-coupled nucleotide-excision repair

0.72	GO:0008408	3'-5' exonuclease activity
0.71	GO:0003887	DNA-directed DNA polymerase activity
0.64	GO:0051539	4 iron, 4 sulfur cluster binding
0.55	GO:0003677	DNA binding
0.52	GO:1901265	nucleoside phosphate binding
0.52	GO:0046872	metal ion binding
0.51	GO:0036094	small molecule binding
0.46	GO:0019899	enzyme binding
0.44	GO:0016895	exodeoxyribonuclease activity, producing 5'-phosphomonoesters
0.40	GO:0003682	chromatin binding

0.59	GO:0005634	nucleus
0.52	GO:0016235	aggresome
0.47	GO:0031974	membrane-enclosed lumen
0.45	GO:0005829	cytosol
0.44	GO:0030894	replisome
0.44	GO:0042575	DNA polymerase complex
0.38	GO:0000781	chromosome, telomeric region
0.37	GO:1990391	DNA repair complex
0.35	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.71

EC:2.7.7.7

GO:0003887

sp|P28347|TEAD1_HUMAN
Transcriptional enhancer factor TEF-1
Search

TEAD1

0.86	Transcriptional enhancer factor TEF-1

0.84	GO:0035329	hippo signaling
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.54	GO:0006351	transcription, DNA-templated
0.47	GO:0051254	positive regulation of RNA metabolic process
0.47	GO:0010557	positive regulation of macromolecule biosynthetic process
0.47	GO:0031328	positive regulation of cellular biosynthetic process
0.45	GO:0048568	embryonic organ development
0.40	GO:1902459	positive regulation of stem cell population maintenance

0.61	GO:0003700	DNA binding transcription factor activity
0.51	GO:0003677	DNA binding
0.48	GO:0001067	regulatory region nucleic acid binding
0.44	GO:0001085	RNA polymerase II transcription factor binding
0.41	GO:0001223	transcription coactivator binding
0.40	GO:0001134	transcription factor activity, transcription factor recruiting
0.38	GO:0046982	protein heterodimerization activity

0.57	GO:0005634	nucleus
0.43	GO:0005667	transcription factor complex
0.43	GO:0031974	membrane-enclosed lumen
0.40	GO:0044446	intracellular organelle part

sp|P28356|HXD9_HUMAN
Homeobox protein Hox-D9
Search

HOXD9

0.73	Homeobox protein Hox-D9

0.64	GO:0007275	multicellular organism development
0.58	GO:0008344	adult locomotory behavior
0.57	GO:0007338	single fertilization
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0014706	striated muscle tissue development
0.56	GO:0006351	transcription, DNA-templated
0.55	GO:0061061	muscle structure development
0.54	GO:0051254	positive regulation of RNA metabolic process

0.64	GO:0043565	sequence-specific DNA binding
0.56	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.56	GO:0001012	RNA polymerase II regulatory region DNA binding
0.53	GO:0003690	double-stranded DNA binding
0.33	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.32	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.50	GO:0031974	membrane-enclosed lumen
0.45	GO:0044446	intracellular organelle part
0.44	GO:0043232	intracellular non-membrane-bounded organelle
0.40	GO:0005667	transcription factor complex
0.37	GO:0016235	aggresome
0.37	GO:0005739	mitochondrion

sp|P28358|HXD10_HUMAN
Homeobox protein Hox-D10
Search

HOXD10

0.97	Homeobox protein Hox-D10 isoform A

0.58	GO:0021520	spinal cord motor neuron cell fate specification
0.57	GO:0048935	peripheral nervous system neuron development
0.57	GO:0035137	hindlimb morphogenesis
0.57	GO:0035136	forelimb morphogenesis
0.57	GO:0009954	proximal/distal pattern formation
0.56	GO:0050905	neuromuscular process
0.55	GO:0008344	adult locomotory behavior
0.55	GO:0030326	embryonic limb morphogenesis
0.55	GO:0048704	embryonic skeletal system morphogenesis
0.55	GO:0007519	skeletal muscle tissue development

0.61	GO:0043565	sequence-specific DNA binding
0.54	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.52	GO:0001012	RNA polymerase II regulatory region DNA binding
0.52	GO:0003682	chromatin binding
0.50	GO:0003690	double-stranded DNA binding
0.33	GO:0005515	protein binding

0.59	GO:0005634	nucleus
0.53	GO:0036464	cytoplasmic ribonucleoprotein granule
0.48	GO:0005829	cytosol
0.48	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part

sp|P28360|MSX1_HUMAN
Homeobox protein MSX-1
Search

MSX1

0.93	Homeobox protein GHOX-7

0.56	GO:0035880	embryonic nail plate morphogenesis
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
0.55	GO:0010468	regulation of gene expression
0.54	GO:2001055	positive regulation of mesenchymal cell apoptotic process
0.54	GO:0060325	face morphogenesis
0.53	GO:0090427	activation of meiosis
0.52	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
0.52	GO:0042475	odontogenesis of dentin-containing tooth

0.64	GO:0043565	sequence-specific DNA binding
0.52	GO:0002039	p53 binding
0.50	GO:0035326	enhancer binding
0.49	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.49	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.48	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.47	GO:0001012	RNA polymerase II regulatory region DNA binding
0.45	GO:0003690	double-stranded DNA binding

0.60	GO:0005634	nucleus
0.45	GO:0031974	membrane-enclosed lumen
0.41	GO:0044446	intracellular organelle part
0.35	GO:0005667	transcription factor complex

sp|P28370|SMCA1_HUMAN
Probable global transcription activator SNF2L1
Search

SMARCA1

0.96	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 isoform A

0.81	GO:0043044	ATP-dependent chromatin remodeling
0.74	GO:0016569	covalent chromatin modification
0.49	GO:2000177	regulation of neural precursor cell proliferation
0.48	GO:0048513	animal organ development
0.48	GO:0060322	head development
0.47	GO:0007417	central nervous system development
0.47	GO:0030154	cell differentiation
0.42	GO:0021999	neural plate anterior/posterior regionalization
0.40	GO:0034101	erythrocyte homeostasis
0.39	GO:0016584	nucleosome positioning

0.83	GO:0031491	nucleosome binding
0.67	GO:0004386	helicase activity
0.61	GO:0016887	ATPase activity
0.55	GO:0030554	adenyl nucleotide binding
0.55	GO:0003677	DNA binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0036310	annealing helicase activity
0.38	GO:0042393	histone binding

0.84	GO:0016589	NURF complex
0.48	GO:0005654	nucleoplasm
0.40	GO:0031213	RSF complex
0.39	GO:0001650	fibrillar center
0.39	GO:0043596	nuclear replication fork
0.39	GO:0090537	CERF complex
0.38	GO:0017053	transcriptional repressor complex
0.38	GO:0000793	condensed chromosome

0.61

GO:0016887

sp|P28472|GBRB3_HUMAN
Gamma-aminobutyric acid receptor subunit beta-3
Search

GABRB3

0.89	Gamma-aminobutyric acid A receptor

0.61	GO:0007165	signal transduction
0.60	GO:0034220	ion transmembrane transport
0.58	GO:0060384	innervation
0.58	GO:0090102	cochlea development
0.57	GO:0060119	inner ear receptor cell development
0.56	GO:0043524	negative regulation of neuron apoptotic process
0.56	GO:0071420	cellular response to histamine
0.55	GO:0007605	sensory perception of sound
0.52	GO:0060021	palate development
0.50	GO:0060078	regulation of postsynaptic membrane potential

0.84	GO:0004890	GABA-A receptor activity
0.76	GO:0005230	extracellular ligand-gated ion channel activity
0.53	GO:0099095	ligand-gated anion channel activity
0.50	GO:0005254	chloride channel activity
0.49	GO:0022835	transmitter-gated channel activity
0.48	GO:0042802	identical protein binding
0.35	GO:0035612	AP-2 adaptor complex binding

0.58	GO:1902711	GABA-A receptor complex
0.56	GO:0005886	plasma membrane
0.49	GO:0098794	postsynapse
0.39	GO:0034707	chloride channel complex
0.38	GO:0030659	cytoplasmic vesicle membrane
0.38	GO:0030054	cell junction
0.37	GO:0060077	inhibitory synapse
0.35	GO:0043195	terminal bouton
0.34	GO:0070062	extracellular exosome
0.33	GO:0005829	cytosol

sp|P28476|GBRR2_HUMAN
Gamma-aminobutyric acid receptor subunit rho-2
Search

GABRR2

0.97	Gamma-aminobutyric acid receptor subunit rho-2

0.61	GO:0007165	signal transduction
0.60	GO:0034220	ion transmembrane transport
0.51	GO:0007601	visual perception
0.39	GO:0006821	chloride transport
0.36	GO:0042462	eye photoreceptor cell development
0.34	GO:0007268	chemical synaptic transmission

0.79	GO:0004890	GABA-A receptor activity
0.76	GO:0005230	extracellular ligand-gated ion channel activity
0.39	GO:0005254	chloride channel activity
0.37	GO:0019904	protein domain specific binding
0.33	GO:0042803	protein homodimerization activity
0.33	GO:0046982	protein heterodimerization activity
0.32	GO:0003676	nucleic acid binding

0.56	GO:0005886	plasma membrane
0.52	GO:1902711	GABA-A receptor complex
0.40	GO:0034707	chloride channel complex
0.39	GO:0098794	postsynapse
0.39	GO:0030054	cell junction
0.34	GO:0030424	axon

sp|P28482|MK01_HUMAN
Mitogen-activated protein kinase 1
Search

MAPK1

0.58	Mitogen-activated protein kinase

0.80	GO:0000165	MAPK cascade
0.55	GO:0019858	cytosine metabolic process
0.55	GO:0060440	trachea formation
0.55	GO:0042473	outer ear morphogenesis
0.54	GO:0061308	cardiac neural crest cell development involved in heart development
0.54	GO:0060020	Bergmann glial cell differentiation
0.54	GO:1903351	cellular response to dopamine
0.54	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus
0.54	GO:0070849	response to epidermal growth factor
0.53	GO:1904355	positive regulation of telomere capping

0.82	GO:0004707	MAP kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0004708	MAP kinase kinase activity
0.53	GO:0001784	phosphotyrosine residue binding
0.51	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.51	GO:0019902	phosphatase binding
0.48	GO:0042802	identical protein binding

0.53	GO:0031143	pseudopodium
0.48	GO:0005901	caveola
0.48	GO:0005829	cytosol
0.47	GO:0005925	focal adhesion
0.46	GO:0005770	late endosome
0.46	GO:0005769	early endosome
0.45	GO:0005634	nucleus
0.44	GO:0005739	mitochondrion
0.44	GO:0005794	Golgi apparatus
0.43	GO:0005856	cytoskeleton

0.82	EC:2.7.11.24	GO:0004707
0.82	KEGG:R00162	GO:0004707

sp|P28562|DUS1_HUMAN
Dual specificity protein phosphatase 1
Search

DUSP1

0.71	Dual specificity protein phosphatase

0.85	GO:0000188	inactivation of MAPK activity
0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.49	GO:0001706	endoderm formation
0.47	GO:0035970	peptidyl-threonine dephosphorylation
0.45	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.44	GO:0042981	regulation of apoptotic process
0.41	GO:0071850	mitotic cell cycle arrest
0.41	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint
0.40	GO:0033574	response to testosterone
0.40	GO:0051447	negative regulation of meiotic cell cycle

0.85	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
0.75	GO:0004725	protein tyrosine phosphatase activity
0.48	GO:0008330	protein tyrosine/threonine phosphatase activity
0.44	GO:1990439	MAP kinase serine/threonine phosphatase activity
0.39	GO:0019838	growth factor binding
0.35	GO:0016301	kinase activity

0.46	GO:0005634	nucleus
0.39	GO:0005737	cytoplasm
0.38	GO:0043233	organelle lumen
0.36	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

0.85

EC:3.1.3

GO:0017017

sp|P28566|5HT1E_HUMAN
5-hydroxytryptamine receptor 1E
Search

HTR1E

0.97	5-hydroxytryptamine (Serotonin) receptor 1E

0.83	GO:0030815	negative regulation of cAMP metabolic process
0.82	GO:0098664	G-protein coupled serotonin receptor signaling pathway
0.74	GO:0098916	anterograde trans-synaptic signaling
0.61	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

0.82	GO:0099589	serotonin receptor activity
0.79	GO:0099528	G-protein coupled neurotransmitter receptor activity
0.79	GO:0008227	G-protein coupled amine receptor activity
0.62	GO:0051378	serotonin binding
0.34	GO:0005515	protein binding

0.65

GO:0005887

integral component of plasma membrane

sp|P28676|GRAN_HUMAN
Grancalcin
Search

GCA

0.91	EF-hand calcium-binding domain-containing protein 2

0.50	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction
0.49	GO:0055118	negative regulation of cardiac muscle contraction
0.49	GO:1901077	regulation of relaxation of muscle
0.49	GO:0010459	negative regulation of heart rate
0.49	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
0.49	GO:1901841	regulation of high voltage-gated calcium channel activity
0.48	GO:0042994	cytoplasmic sequestering of transcription factor
0.48	GO:0086004	regulation of cardiac muscle cell contraction
0.48	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
0.48	GO:2000678	negative regulation of transcription regulatory region DNA binding

0.70	GO:0005509	calcium ion binding
0.54	GO:0046982	protein heterodimerization activity
0.50	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.50	GO:0042803	protein homodimerization activity
0.47	GO:0070491	repressing transcription factor binding
0.47	GO:0002020	protease binding
0.34	GO:0005246	calcium channel regulator activity
0.34	GO:0044325	ion channel binding
0.33	GO:0005102	receptor binding

0.51	GO:0005829	cytosol
0.49	GO:0042584	chromaffin granule membrane
0.47	GO:0070062	extracellular exosome
0.47	GO:0030018	Z disc
0.44	GO:0005886	plasma membrane
0.43	GO:0005789	endoplasmic reticulum membrane
0.42	GO:0005654	nucleoplasm
0.38	GO:0044326	dendritic spine neck
0.37	GO:0005790	smooth endoplasmic reticulum
0.36	GO:0016529	sarcoplasmic reticulum

sp|P28698|MZF1_HUMAN
Myeloid zinc finger 1
Search

MZF1

0.63	Myeloid zinc finger 1

0.55	GO:2001141	regulation of RNA biosynthetic process
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.52	GO:0006351	transcription, DNA-templated
0.48	GO:0051254	positive regulation of RNA metabolic process
0.47	GO:0010557	positive regulation of macromolecule biosynthetic process
0.47	GO:0031328	positive regulation of cellular biosynthetic process
0.47	GO:0051253	negative regulation of RNA metabolic process
0.47	GO:0010558	negative regulation of macromolecule biosynthetic process
0.47	GO:0031327	negative regulation of cellular biosynthetic process

0.59	GO:0003700	DNA binding transcription factor activity
0.51	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.50	GO:0042802	identical protein binding
0.49	GO:0046872	metal ion binding
0.46	GO:0046983	protein dimerization activity
0.40	GO:0003682	chromatin binding

0.59	GO:0005634	nucleus
0.36	GO:0005615	extracellular space
0.30	GO:0016020	membrane

sp|P28702|RXRB_HUMAN
Retinoic acid receptor RXR-beta
Search

RXRB

0.97	Retinoid X nuclear receptor beta

0.78	GO:0043401	steroid hormone mediated signaling pathway
0.58	GO:0097659	nucleic acid-templated transcription
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.54	GO:0030522	intracellular receptor signaling pathway
0.54	GO:0010467	gene expression
0.53	GO:0034645	cellular macromolecule biosynthetic process
0.51	GO:1902680	positive regulation of RNA biosynthetic process
0.38	GO:0060038	cardiac muscle cell proliferation

0.79	GO:0003707	steroid hormone receptor activity
0.64	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.53	GO:0001012	RNA polymerase II regulatory region DNA binding
0.50	GO:0003690	double-stranded DNA binding
0.37	GO:0042809	vitamin D receptor binding
0.37	GO:0035326	enhancer binding
0.36	GO:0003713	transcription coactivator activity
0.36	GO:0042803	protein homodimerization activity

0.61	GO:0005634	nucleus
0.35	GO:0005581	collagen trimer
0.34	GO:0070013	intracellular organelle lumen
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.34	GO:0043235	receptor complex
0.33	GO:0044446	intracellular organelle part
0.33	GO:0005667	transcription factor complex
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0044444	cytoplasmic part
0.30	GO:0016020	membrane

sp|P28715|ERCC5_HUMAN
DNA repair protein complementing XP-G cells
Search

ERCC5

0.91	Excision repair cross-complementing rodent repair deficiency, complementation group 5

0.73	GO:0006289	nucleotide-excision repair
0.64	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.48	GO:0010225	response to UV-C
0.45	GO:0043066	negative regulation of apoptotic process
0.44	GO:0009650	UV protection
0.43	GO:0035264	multicellular organism growth
0.43	GO:0008340	determination of adult lifespan

0.74	GO:0003697	single-stranded DNA binding
0.66	GO:0004519	endonuclease activity
0.49	GO:0004536	deoxyribonuclease activity
0.48	GO:0000405	bubble DNA binding
0.47	GO:0047485	protein N-terminus binding
0.44	GO:0042803	protein homodimerization activity
0.43	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.45	GO:1902554	serine/threonine protein kinase complex
0.44	GO:0000428	DNA-directed RNA polymerase complex
0.44	GO:0005667	transcription factor complex
0.41	GO:0031974	membrane-enclosed lumen
0.41	GO:0030894	replisome
0.30	GO:0016020	membrane

sp|P28749|RBL1_HUMAN
Retinoblastoma-like protein 1
Search

RBL1

0.97	RB transcriptional corepressor like 1

0.80	GO:2000773	negative regulation of cellular senescence
0.77	GO:0043550	regulation of lipid kinase activity
0.73	GO:0051726	regulation of cell cycle
0.71	GO:0006357	regulation of transcription by RNA polymerase II
0.67	GO:0007049	cell cycle
0.63	GO:0045892	negative regulation of transcription, DNA-templated

0.79	GO:1990841	promoter-specific chromatin binding
0.66	GO:0008134	transcription factor binding

0.75	GO:0005667	transcription factor complex
0.63	GO:0005654	nucleoplasm
0.38	GO:0005730	nucleolus
0.37	GO:0005829	cytosol

sp|P28799|GRN_HUMAN
Granulins
Search

GRN

0.61

Granulins

0.71	GO:0048675	axon extension
0.71	GO:0071340	skeletal muscle acetylcholine-gated channel clustering
0.66	GO:0001889	liver development
0.46	GO:0042742	defense response to bacterium
0.44	GO:0001835	blastocyst hatching
0.44	GO:0010469	regulation of receptor activity
0.43	GO:0043312	neutrophil degranulation
0.43	GO:0007566	embryo implantation
0.42	GO:0050679	positive regulation of epithelial cell proliferation
0.37	GO:0007165	signal transduction

0.46	GO:0005125	cytokine activity
0.41	GO:0008083	growth factor activity
0.37	GO:0003723	RNA binding

0.57	GO:0005764	lysosome
0.55	GO:0005768	endosome
0.52	GO:0005783	endoplasmic reticulum
0.47	GO:0005886	plasma membrane
0.46	GO:0005576	extracellular region
0.43	GO:0034774	secretory granule lumen
0.43	GO:0005775	vacuolar lumen
0.37	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

sp|P28827|PTPRM_HUMAN
Receptor-type tyrosine-protein phosphatase mu
Search

PTPRM

0.43	Receptor-type tyrosine-protein phosphatase mu

0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.57	GO:0010842	retina layer formation
0.57	GO:0031290	retinal ganglion cell axon guidance
0.57	GO:0001937	negative regulation of endothelial cell proliferation
0.56	GO:0010596	negative regulation of endothelial cell migration
0.55	GO:0016525	negative regulation of angiogenesis
0.52	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.49	GO:0042493	response to drug
0.44	GO:0007165	signal transduction
0.37	GO:0097755	positive regulation of blood vessel diameter

0.74	GO:0004725	protein tyrosine phosphatase activity
0.58	GO:0019198	transmembrane receptor protein phosphatase activity
0.54	GO:0045296	cadherin binding
0.48	GO:0042802	identical protein binding

0.55	GO:0005913	cell-cell adherens junction
0.54	GO:0030027	lamellipodium
0.53	GO:0048471	perinuclear region of cytoplasm
0.41	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.74

GO:0004725

sp|P28838|AMPL_HUMAN
Cytosol aminopeptidase
Search

LAP3

0.70	Cytosol aminopeptidase

0.61

GO:0006508

proteolysis

0.74	GO:0008235	metalloexopeptidase activity
0.73	GO:0030145	manganese ion binding
0.71	GO:0004177	aminopeptidase activity
0.35	GO:0097718	disordered domain specific binding

0.55	GO:0030496	midbody
0.49	GO:0005654	nucleoplasm
0.49	GO:0005737	cytoplasm
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.36	GO:0031984	organelle subcompartment
0.36	GO:0012505	endomembrane system

0.71

EC:3.4.11

GO:0004177

sp|P28845|DHI1_HUMAN
Corticosteroid 11-beta-dehydrogenase isozyme 1
Search

HSD11B1

0.97	Corticosteroid 11-beta-dehydrogenase isozyme 1

0.57	GO:0030324	lung development
0.52	GO:0055114	oxidation-reduction process
0.42	GO:0008202	steroid metabolic process
0.37	GO:0042445	hormone metabolic process
0.36	GO:0043456	regulation of pentose-phosphate shunt
0.35	GO:0071392	cellular response to estradiol stimulus
0.35	GO:0008610	lipid biosynthetic process
0.34	GO:0031667	response to nutrient levels
0.34	GO:0016042	lipid catabolic process
0.34	GO:1901361	organic cyclic compound catabolic process

0.63	GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
0.47	GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity
0.35	GO:0005496	steroid binding
0.34	GO:0050661	NADP binding
0.33	GO:0102132	3-oxo-pimeloyl-[acp] methyl ester reductase activity
0.33	GO:0102131	3-oxo-glutaryl-[acp] methyl ester reductase activity
0.33	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity

0.41	GO:0005789	endoplasmic reticulum membrane
0.35	GO:0005791	rough endoplasmic reticulum
0.35	GO:0044428	nuclear part
0.35	GO:0045177	apical part of cell
0.34	GO:0031090	organelle membrane
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0031967	organelle envelope
0.30	GO:0031224	intrinsic component of membrane

0.47

EC:1.1.1.146

GO:0070524

sp|P28906|CD34_HUMAN
Hematopoietic progenitor cell antigen CD34
Search

CD34

0.97	Hematopoietic progenitor cell antigen CD34

0.72	GO:0007155	cell adhesion
0.71	GO:0071971	extracellular exosome assembly
0.70	GO:1900035	negative regulation of cellular response to heat
0.70	GO:2001214	positive regulation of vasculogenesis
0.69	GO:1901258	positive regulation of macrophage colony-stimulating factor production
0.69	GO:1900041	negative regulation of interleukin-2 secretion
0.69	GO:0071655	regulation of granulocyte colony-stimulating factor production
0.69	GO:0045019	negative regulation of nitric oxide biosynthetic process
0.69	GO:0042482	positive regulation of odontogenesis
0.69	GO:0071636	positive regulation of transforming growth factor beta production

0.64	GO:0043199	sulfate binding
0.56	GO:0030246	carbohydrate binding
0.54	GO:0008134	transcription factor binding
0.34	GO:0003735	structural constituent of ribosome

0.65	GO:0045171	intercellular bridge
0.64	GO:0009897	external side of plasma membrane
0.62	GO:0036053	glomerular endothelium fenestra
0.61	GO:0048471	perinuclear region of cytoplasm
0.58	GO:0009925	basal plasma membrane
0.55	GO:0016324	apical plasma membrane
0.53	GO:0005764	lysosome
0.42	GO:0005887	integral component of plasma membrane
0.34	GO:0005840	ribosome

sp|P28907|CD38_HUMAN
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Search

CD38

0.97	ADP-ribosyl cyclase 1

0.51	GO:0030890	positive regulation of B cell proliferation
0.51	GO:0050853	B cell receptor signaling pathway
0.48	GO:0043066	negative regulation of apoptotic process
0.46	GO:0045893	positive regulation of transcription, DNA-templated
0.45	GO:0045892	negative regulation of transcription, DNA-templated
0.45	GO:0042493	response to drug
0.30	GO:0008152	metabolic process

0.87	GO:0050135	NAD(P)+ nucleosidase activity
0.86	GO:0003953	NAD+ nucleosidase activity
0.46	GO:0016849	phosphorus-oxygen lyase activity
0.46	GO:0042802	identical protein binding

0.47	GO:0009986	cell surface
0.36	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.87

EC:3.2.2.6

GO:0050135

sp|P28908|TNR8_HUMAN
Tumor necrosis factor receptor superfamily member 8
Search

0.63	Tumor necrosis factor receptor superfamily member 8

0.57	GO:0007165	signal transduction
0.56	GO:0045556	positive regulation of TRAIL biosynthetic process
0.54	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
0.52	GO:0071260	cellular response to mechanical stimulus
0.49	GO:0043065	positive regulation of apoptotic process
0.30	GO:0040011	locomotion
0.30	GO:0050768	negative regulation of neurogenesis
0.30	GO:0042221	response to chemical
0.30	GO:0030182	neuron differentiation
0.30	GO:0032989	cellular component morphogenesis

0.65	GO:0004888	transmembrane signaling receptor activity
0.30	GO:0043121	neurotrophin binding

0.30	GO:0031224	intrinsic component of membrane
0.30	GO:0043005	neuron projection
0.30	GO:0044459	plasma membrane part
0.30	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:1903561	extracellular vesicle
0.30	GO:0005615	extracellular space
0.30	GO:0005737	cytoplasm

sp|P29016|CD1B_HUMAN
T-cell surface glycoprotein CD1b
Search

0.95	T-cell surface glycoprotein CD1e, membrane-associated-like

0.60	GO:0002250	adaptive immune response
0.42	GO:0048007	antigen processing and presentation, exogenous lipid antigen via MHC class Ib

0.43	GO:0030883	endogenous lipid antigen binding
0.42	GO:0030884	exogenous lipid antigen binding
0.42	GO:0030881	beta-2-microglobulin binding
0.42	GO:0071723	lipopeptide binding

0.57	GO:0005764	lysosome
0.56	GO:0098852	lytic vacuole membrane
0.55	GO:0005768	endosome
0.53	GO:0044433	cytoplasmic vesicle part
0.44	GO:0005886	plasma membrane
0.41	GO:0005775	vacuolar lumen
0.39	GO:0000139	Golgi membrane
0.30	GO:0044425	membrane part

sp|P29017|CD1C_HUMAN
T-cell surface glycoprotein CD1c
Search

0.94	T-cell surface glycoprotein CD1b-1

0.57

GO:0002250

adaptive immune response

0.54	GO:0010008	endosome membrane
0.46	GO:0005765	lysosomal membrane
0.43	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

sp|P29033|CXB2_HUMAN
Gap junction beta-2 protein
Search

GJB2

0.63	Gap junction protein (Fragment)

0.60	GO:0007154	cell communication
0.58	GO:0016264	gap junction assembly
0.54	GO:0007605	sensory perception of sound
0.53	GO:0043583	ear development
0.50	GO:0048562	embryonic organ morphogenesis
0.50	GO:0090596	sensory organ morphogenesis
0.44	GO:0023052	signaling
0.43	GO:0032496	response to lipopolysaccharide
0.43	GO:0007568	aging
0.42	GO:1905867	epididymis development

0.57	GO:0005243	gap junction channel activity
0.50	GO:0042802	identical protein binding

0.83	GO:0005922	connexin complex
0.41	GO:0097449	astrocyte projection
0.40	GO:0016328	lateral plasma membrane
0.40	GO:0005829	cytosol
0.39	GO:0016324	apical plasma membrane
0.39	GO:0044297	cell body
0.39	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.30	GO:0016021	integral component of membrane

sp|P29034|S10A2_HUMAN
Protein S100-A2
Search

sp|P29074|PTN4_HUMAN
Tyrosine-protein phosphatase non-receptor type 4
Search

PTPN4

0.61	Tyrosine-protein phosphatase non-receptor type

0.71	GO:0035335	peptidyl-tyrosine dephosphorylation
0.35	GO:0071345	cellular response to cytokine stimulus

0.71	GO:0004725	protein tyrosine phosphatase activity
0.66	GO:0008092	cytoskeletal protein binding

0.66	GO:0005856	cytoskeleton
0.51	GO:0009898	cytoplasmic side of plasma membrane
0.46	GO:0005737	cytoplasm
0.34	GO:0005654	nucleoplasm

0.71

GO:0004725

sp|P29083|T2EA_HUMAN
General transcription factor IIE subunit 1
Search

GTF2E1

0.89	General transcription factor IIE subunit 1

0.78	GO:0006367	transcription initiation from RNA polymerase II promoter
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.36	GO:0042795	snRNA transcription by RNA polymerase II
0.35	GO:0006368	transcription elongation from RNA polymerase II promoter
0.34	GO:0006413	translational initiation
0.34	GO:0016192	vesicle-mediated transport
0.33	GO:0016032	viral process

0.63	GO:0043565	sequence-specific DNA binding
0.34	GO:0046872	metal ion binding
0.34	GO:0003743	translation initiation factor activity
0.33	GO:0005515	protein binding

0.58	GO:0097550	transcriptional preinitiation complex
0.53	GO:0005669	transcription factor TFIID complex
0.48	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|P29084|T2EB_HUMAN
Transcription initiation factor IIE subunit beta
Search

GTF2E2

0.75	Transcription initiation factor IIE subunit beta

0.78	GO:0006367	transcription initiation from RNA polymerase II promoter
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.46	GO:0006413	translational initiation
0.35	GO:0042795	snRNA transcription by RNA polymerase II
0.35	GO:0006368	transcription elongation from RNA polymerase II promoter

0.54	GO:0003677	DNA binding
0.46	GO:0003743	translation initiation factor activity
0.34	GO:0005515	protein binding

0.84	GO:0005673	transcription factor TFIIE complex
0.52	GO:0016607	nuclear speck
0.52	GO:0005669	transcription factor TFIID complex
0.47	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|P29120|NEC1_HUMAN
Neuroendocrine convertase 1
Search

PCSK1

0.95	Proprotein convertase subtilisin kexin type 1 variant 1

0.61	GO:0006508	proteolysis
0.51	GO:0042445	hormone metabolic process
0.50	GO:0051604	protein maturation
0.44	GO:0043043	peptide biosynthetic process
0.36	GO:0010157	response to chlorate
0.36	GO:0043278	response to morphine
0.35	GO:0048678	response to axon injury
0.35	GO:0021983	pituitary gland development
0.35	GO:0070542	response to fatty acid
0.35	GO:0051384	response to glucocorticoid

0.69	GO:0004252	serine-type endopeptidase activity
0.50	GO:0042802	identical protein binding
0.36	GO:0043559	insulin binding
0.34	GO:0051087	chaperone binding
0.34	GO:0032403	protein complex binding

0.52	GO:0005615	extracellular space
0.39	GO:0030133	transport vesicle
0.39	GO:0034774	secretory granule lumen
0.35	GO:0005783	endoplasmic reticulum
0.35	GO:0043204	perikaryon
0.35	GO:0043679	axon terminus
0.35	GO:0030425	dendrite
0.35	GO:0005802	trans-Golgi network
0.35	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0004252

sp|P29122|PCSK6_HUMAN
Proprotein convertase subtilisin/kexin type 6
Search

PCSK6

0.94	Proprotein convertase subtilisin/kexin type 6

0.61	GO:0032902	nerve growth factor production
0.61	GO:0006508	proteolysis
0.57	GO:0007354	zygotic determination of anterior/posterior axis, embryo
0.54	GO:0007368	determination of left/right symmetry
0.52	GO:0042445	hormone metabolic process
0.51	GO:0009100	glycoprotein metabolic process
0.50	GO:0051604	protein maturation
0.49	GO:0032940	secretion by cell
0.45	GO:0006518	peptide metabolic process
0.36	GO:0070268	cornification

0.69	GO:0004252	serine-type endopeptidase activity
0.60	GO:0048406	nerve growth factor binding
0.55	GO:0008201	heparin binding
0.33	GO:0016301	kinase activity

0.52	GO:0009986	cell surface
0.51	GO:0031012	extracellular matrix
0.51	GO:0005615	extracellular space
0.36	GO:0005796	Golgi lumen
0.34	GO:0005783	endoplasmic reticulum
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0004252

sp|P29144|TPP2_HUMAN
Tripeptidyl-peptidase 2
Search

TPP2

0.86	Tripeptidyl-peptidase 2

0.61	GO:0006508	proteolysis
0.37	GO:0000209	protein polyubiquitination

0.86	GO:0008240	tripeptidyl-peptidase activity
0.69	GO:0004252	serine-type endopeptidase activity
0.40	GO:0042277	peptide binding
0.40	GO:0004177	aminopeptidase activity
0.39	GO:0042802	identical protein binding

0.44	GO:0016604	nuclear body
0.41	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.86

EC:3.4.14

GO:0008240

sp|P29218|IMPA1_HUMAN
Inositol monophosphatase 1
Search

IMPA1

0.41	Inositol monophosphatase 1

0.80	GO:0006021	inositol biosynthetic process
0.79	GO:0046855	inositol phosphate dephosphorylation
0.75	GO:0046854	phosphatidylinositol phosphorylation
0.50	GO:0006661	phosphatidylinositol biosynthetic process
0.44	GO:0007165	signal transduction
0.35	GO:0010226	response to lithium ion

0.79	GO:0008934	inositol monophosphate 1-phosphatase activity
0.79	GO:0052832	inositol monophosphate 3-phosphatase activity
0.79	GO:0052833	inositol monophosphate 4-phosphatase activity
0.58	GO:0031403	lithium ion binding
0.49	GO:0042803	protein homodimerization activity
0.49	GO:0030145	manganese ion binding
0.45	GO:0000287	magnesium ion binding

0.38	GO:0005737	cytoplasm
0.36	GO:0070062	extracellular exosome
0.34	GO:0043025	neuronal cell body
0.34	GO:0030424	axon
0.30	GO:0016020	membrane

0.79

EC:3.1.3.25

GO:0008934

sp|P29274|AA2AR_HUMAN
Adenosine receptor A2a
Search

ADORA2A

0.95	Adenosine receptor A2

0.85	GO:0001973	adenosine receptor signaling pathway
0.59	GO:0032230	positive regulation of synaptic transmission, GABAergic
0.59	GO:0060080	inhibitory postsynaptic potential
0.58	GO:0001963	synaptic transmission, dopaminergic
0.58	GO:0001975	response to amphetamine
0.58	GO:0042755	eating behavior
0.58	GO:0046636	negative regulation of alpha-beta T cell activation
0.58	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.56	GO:0050728	negative regulation of inflammatory response
0.55	GO:2001235	positive regulation of apoptotic signaling pathway

0.85	GO:0001609	G-protein coupled adenosine receptor activity
0.51	GO:0042802	identical protein binding
0.50	GO:0019899	enzyme binding
0.42	GO:0031802	type 5 metabotropic glutamate receptor binding
0.41	GO:0051393	alpha-actinin binding
0.38	GO:0046982	protein heterodimerization activity
0.34	GO:0016519	gastric inhibitory peptide receptor activity

0.55	GO:0005886	plasma membrane
0.52	GO:0098794	postsynapse
0.41	GO:0044304	main axon
0.40	GO:0032279	asymmetric synapse
0.40	GO:0048786	presynaptic active zone
0.40	GO:0043025	neuronal cell body
0.40	GO:0030425	dendrite
0.40	GO:0031252	cell leading edge
0.39	GO:0005882	intermediate filament
0.37	GO:0012505	endomembrane system

sp|P29275|AA2BR_HUMAN
Adenosine receptor A2b
Search

ADORA2B

0.92	Adenosine receptor A2

0.85	GO:0001973	adenosine receptor signaling pathway
0.56	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.56	GO:0002880	regulation of chronic inflammatory response to non-antigenic stimulus
0.54	GO:0002678	positive regulation of chronic inflammatory response
0.54	GO:0060087	relaxation of vascular smooth muscle
0.54	GO:0033008	positive regulation of mast cell activation involved in immune response
0.53	GO:0043302	positive regulation of leukocyte degranulation
0.53	GO:0002888	positive regulation of myeloid leukocyte mediated immunity
0.53	GO:0031284	positive regulation of guanylate cyclase activity
0.53	GO:0043304	regulation of mast cell degranulation

0.85	GO:0001609	G-protein coupled adenosine receptor activity
0.42	GO:0042802	identical protein binding
0.42	GO:0019899	enzyme binding
0.37	GO:0031802	type 5 metabotropic glutamate receptor binding
0.36	GO:0051393	alpha-actinin binding
0.35	GO:0046982	protein heterodimerization activity

0.55	GO:0005886	plasma membrane
0.43	GO:0098794	postsynapse
0.37	GO:0005622	intracellular
0.36	GO:0044304	main axon
0.36	GO:0032279	asymmetric synapse
0.36	GO:0048786	presynaptic active zone
0.35	GO:0043025	neuronal cell body
0.35	GO:0030425	dendrite
0.35	GO:0031252	cell leading edge
0.35	GO:0099512	supramolecular fiber

sp|P29279|CTGF_HUMAN
Connective tissue growth factor
Search

CTGF

0.95	Connective tissue growth factor XCTGF

0.73	GO:0001558	regulation of cell growth
0.59	GO:0035988	chondrocyte proliferation
0.58	GO:0001502	cartilage condensation
0.57	GO:0051496	positive regulation of stress fiber assembly
0.57	GO:0032330	regulation of chondrocyte differentiation
0.56	GO:0046330	positive regulation of JNK cascade
0.56	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.55	GO:0030324	lung development
0.55	GO:0008543	fibroblast growth factor receptor signaling pathway
0.55	GO:0001894	tissue homeostasis

0.77	GO:0005520	insulin-like growth factor binding
0.58	GO:0005178	integrin binding
0.57	GO:0008201	heparin binding
0.55	GO:0008022	protein C-terminus binding
0.39	GO:0001968	fibronectin binding
0.37	GO:0008083	growth factor activity

0.63	GO:0005576	extracellular region
0.38	GO:0005801	cis-Golgi network
0.37	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0005938	cell cortex
0.36	GO:0005829	cytosol
0.33	GO:0005886	plasma membrane

sp|P29317|EPHA2_HUMAN
Ephrin type-A receptor 2
Search

EPHA2

0.94	Eph receptor tyrosine kinase

0.84	GO:0048013	ephrin receptor signaling pathway
0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.59	GO:1901491	negative regulation of lymphangiogenesis
0.59	GO:0048320	axial mesoderm formation
0.58	GO:0060035	notochord cell development
0.58	GO:1904238	pericyte cell differentiation
0.58	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis
0.58	GO:0014028	notochord formation
0.58	GO:0070309	lens fiber cell morphogenesis
0.57	GO:0032682	negative regulation of chemokine production

0.85	GO:0005003	ephrin receptor activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0045296	cadherin binding

0.66	GO:0005887	integral component of plasma membrane
0.56	GO:0009986	cell surface
0.50	GO:0031256	leading edge membrane
0.49	GO:0030027	lamellipodium
0.49	GO:0005925	focal adhesion
0.36	GO:0005622	intracellular

sp|P29320|EPHA3_HUMAN
Ephrin type-A receptor 3
Search

EPHA3

0.91	Eph receptor A3, like

0.84	GO:0048013	ephrin receptor signaling pathway
0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.68	GO:0071300	cellular response to retinoic acid
0.68	GO:0045806	negative regulation of endocytosis
0.67	GO:0051893	regulation of focal adhesion assembly
0.67	GO:1903078	positive regulation of protein localization to plasma membrane
0.65	GO:0010976	positive regulation of neuron projection development
0.63	GO:0070507	regulation of microtubule cytoskeleton organization
0.61	GO:0032956	regulation of actin cytoskeleton organization
0.60	GO:0043087	regulation of GTPase activity

0.85	GO:0005003	ephrin receptor activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.65	GO:0005887	integral component of plasma membrane
0.63	GO:0005769	early endosome

sp|P29322|EPHA8_HUMAN
Ephrin type-A receptor 8
Search

EPHA8

0.86	EPH receptor A8

0.84	GO:0048013	ephrin receptor signaling pathway
0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.76	GO:0071372	cellular response to follicle-stimulating hormone stimulus
0.69	GO:0006929	substrate-dependent cell migration
0.69	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
0.69	GO:0016322	neuron remodeling
0.68	GO:0033628	regulation of cell adhesion mediated by integrin
0.67	GO:0007411	axon guidance
0.64	GO:0046777	protein autophosphorylation
0.63	GO:0043410	positive regulation of MAPK cascade

0.86	GO:0005004	GPI-linked ephrin receptor activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.66	GO:0005887	integral component of plasma membrane
0.62	GO:0043005	neuron projection
0.46	GO:0005912	adherens junction

sp|P29323|EPHB2_HUMAN
Ephrin type-B receptor 2
Search

EPHB2

0.91	EPH receptor B2

0.84	GO:0048013	ephrin receptor signaling pathway
0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.70	GO:0106028	neuron projection retraction
0.70	GO:0099557	trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
0.70	GO:1904782	negative regulation of NMDA glutamate receptor activity
0.70	GO:1904783	positive regulation of NMDA glutamate receptor activity
0.69	GO:0048170	positive regulation of long-term neuronal synaptic plasticity
0.69	GO:0051389	inactivation of MAPKK activity
0.68	GO:0031915	positive regulation of synaptic plasticity
0.67	GO:0021631	optic nerve morphogenesis

0.85	GO:0005003	ephrin receptor activity
0.67	GO:0008046	axon guidance receptor activity
0.64	GO:0001540	amyloid-beta binding
0.57	GO:0042802	identical protein binding
0.56	GO:0005102	receptor binding
0.55	GO:0044877	macromolecular complex binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding

0.66	GO:0005887	integral component of plasma membrane
0.61	GO:0043025	neuronal cell body
0.61	GO:0030425	dendrite
0.60	GO:0030424	axon
0.48	GO:0005634	nucleus

sp|P29350|PTN6_HUMAN
Tyrosine-protein phosphatase non-receptor type 6
Search

PTPN6

0.60	Tyrosine-protein phosphatase non-receptor type

0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.59	GO:0033277	abortive mitotic cell cycle
0.58	GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin
0.58	GO:0050859	negative regulation of B cell receptor signaling pathway
0.57	GO:0050860	negative regulation of T cell receptor signaling pathway
0.56	GO:0042267	natural killer cell mediated cytotoxicity
0.56	GO:0035855	megakaryocyte development
0.56	GO:0030220	platelet formation
0.56	GO:0033630	positive regulation of cell adhesion mediated by integrin
0.56	GO:0045577	regulation of B cell differentiation

0.74	GO:0004725	protein tyrosine phosphatase activity
0.59	GO:0140031	phosphorylation-dependent protein binding
0.58	GO:0019198	transmembrane receptor protein phosphatase activity
0.56	GO:0042169	SH2 domain binding
0.55	GO:0001784	phosphotyrosine residue binding
0.52	GO:0050839	cell adhesion molecule binding
0.52	GO:0017124	SH3 domain binding
0.52	GO:0019901	protein kinase binding
0.36	GO:0046703	natural killer cell lectin-like receptor binding

0.57	GO:0042105	alpha-beta T cell receptor complex
0.51	GO:0005911	cell-cell junction
0.49	GO:0005730	nucleolus
0.44	GO:0005737	cytoplasm
0.43	GO:0043234	protein complex
0.36	GO:0070062	extracellular exosome
0.35	GO:0031983	vesicle lumen
0.34	GO:0097708	intracellular vesicle
0.34	GO:0005654	nucleoplasm
0.33	GO:0012505	endomembrane system

0.74

GO:0004725

sp|P29353|SHC1_HUMAN
SHC-transforming protein 1
Search

SHC1

0.92	SHC (Src homology 2 domain containing) transforming protein 1

0.80	GO:0001525	angiogenesis
0.69	GO:0000187	activation of MAPK activity
0.67	GO:0007173	epidermal growth factor receptor signaling pathway
0.67	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.64	GO:0000165	MAPK cascade
0.64	GO:0071363	cellular response to growth factor stimulus
0.63	GO:0043066	negative regulation of apoptotic process
0.63	GO:0042742	defense response to bacterium
0.62	GO:0007507	heart development
0.62	GO:0042127	regulation of cell proliferation

0.85	GO:0030971	receptor tyrosine kinase binding
0.73	GO:0005168	neurotrophin TRKA receptor binding
0.72	GO:0048408	epidermal growth factor binding
0.70	GO:0005159	insulin-like growth factor receptor binding
0.70	GO:0005158	insulin receptor binding
0.69	GO:0046875	ephrin receptor binding
0.69	GO:0001784	phosphotyrosine residue binding
0.40	GO:0019904	protein domain specific binding

0.48	GO:0005886	plasma membrane
0.45	GO:0005622	intracellular

sp|P29371|NK3R_HUMAN
Neuromedin-K receptor
Search

TACR3

0.97	Neuromedin-K receptor

0.85	GO:0007217	tachykinin receptor signaling pathway
0.60	GO:1902093	positive regulation of flagellated sperm motility
0.41	GO:0070472	regulation of uterine smooth muscle contraction
0.39	GO:0043278	response to morphine
0.39	GO:0042053	regulation of dopamine metabolic process
0.39	GO:0010460	positive regulation of heart rate
0.39	GO:0045777	positive regulation of blood pressure
0.39	GO:0045987	positive regulation of smooth muscle contraction
0.39	GO:0042220	response to cocaine
0.39	GO:0060259	regulation of feeding behavior

0.86	GO:0004995	tachykinin receptor activity
0.36	GO:0050254	rhodopsin kinase activity
0.33	GO:0005515	protein binding

0.58	GO:0097225	sperm midpiece
0.56	GO:0005886	plasma membrane
0.38	GO:0061827	sperm head
0.38	GO:0043025	neuronal cell body
0.38	GO:0030425	dendrite
0.38	GO:0031252	cell leading edge
0.35	GO:0005634	nucleus
0.33	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.36

EC:2.7.11.14

GO:0050254

sp|P29372|3MG_HUMAN
DNA-3-methyladenine glycosylase
Search

MPG

0.50	N-methylpurine DNA glycosylase

0.73	GO:0006284	base-excision repair
0.35	GO:0006307	DNA dealkylation involved in DNA repair

0.79	GO:0003905	alkylbase DNA N-glycosylase activity
0.55	GO:0003677	DNA binding
0.34	GO:0005515	protein binding

0.38	GO:0042645	mitochondrial nucleoid
0.35	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:3.2.2.21

GO:0003905

sp|P29373|RABP2_HUMAN
Cellular retinoic acid-binding protein 2
Search

CRABP2

0.94	Cellular retinoic acid binding protein I

0.74	GO:0042573	retinoic acid metabolic process
0.72	GO:0048385	regulation of retinoic acid receptor signaling pathway
0.68	GO:0042363	fat-soluble vitamin catabolic process
0.67	GO:0016103	diterpenoid catabolic process
0.57	GO:0048672	positive regulation of collateral sprouting
0.56	GO:0072329	monocarboxylic acid catabolic process
0.56	GO:0035115	embryonic forelimb morphogenesis
0.46	GO:0021575	hindbrain morphogenesis
0.35	GO:0016102	diterpenoid biosynthetic process
0.35	GO:0008544	epidermis development

0.84	GO:0001972	retinoic acid binding
0.47	GO:0019841	retinol binding
0.46	GO:0016918	retinal binding
0.36	GO:0005515	protein binding

0.50	GO:0005634	nucleus
0.49	GO:0005829	cytosol
0.47	GO:0031974	membrane-enclosed lumen
0.42	GO:0044446	intracellular organelle part
0.37	GO:0070852	cell body fiber
0.37	GO:0005783	endoplasmic reticulum
0.36	GO:0070062	extracellular exosome
0.36	GO:0030424	axon
0.33	GO:0043234	protein complex

sp|P29374|ARI4A_HUMAN
AT-rich interactive domain-containing protein 4A
Search

ARID4A

0.85	AT-rich interaction domain 4A

0.82	GO:0097368	establishment of Sertoli cell barrier
0.81	GO:0036124	histone H3-K9 trimethylation
0.78	GO:0034773	histone H4-K20 trimethylation
0.78	GO:0006349	regulation of gene expression by genetic imprinting
0.75	GO:0080182	histone H3-K4 trimethylation
0.74	GO:0048821	erythrocyte development
0.71	GO:0007283	spermatogenesis
0.67	GO:0045944	positive regulation of transcription by RNA polymerase II
0.62	GO:0045892	negative regulation of transcription, DNA-templated

0.55	GO:0003677	DNA binding
0.54	GO:0001067	regulatory region nucleic acid binding

0.69	GO:0017053	transcriptional repressor complex
0.61	GO:0005634	nucleus
0.60	GO:0005829	cytosol
0.59	GO:0031974	membrane-enclosed lumen
0.51	GO:0044446	intracellular organelle part
0.50	GO:0005886	plasma membrane

sp|P29375|KDM5A_HUMAN
Lysine-specific demethylase 5A
Search

KDM5A

0.95	Lysine-specific demethylase 5A

0.60	GO:0034721	histone H3-K4 demethylation, trimethyl-H3-K4-specific
0.58	GO:1901726	negative regulation of histone deacetylase activity
0.55	GO:0032259	methylation
0.54	GO:0051090	regulation of DNA binding transcription factor activity
0.54	GO:0032922	circadian regulation of gene expression
0.51	GO:0045893	positive regulation of transcription, DNA-templated
0.50	GO:0000122	negative regulation of transcription by RNA polymerase II
0.41	GO:0008584	male gonad development
0.41	GO:0033169	histone H3-K9 demethylation
0.40	GO:0007283	spermatogenesis

0.60	GO:0034647	histone demethylase activity (H3-trimethyl-K4 specific)
0.60	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)
0.56	GO:0035064	methylated histone binding
0.56	GO:0001046	core promoter sequence-specific DNA binding
0.55	GO:0008168	methyltransferase activity
0.53	GO:0031490	chromatin DNA binding
0.53	GO:0046872	metal ion binding
0.51	GO:0003713	transcription coactivator activity
0.45	GO:0003700	DNA binding transcription factor activity
0.41	GO:0032454	histone demethylase activity (H3-K9 specific)

0.60	GO:0005634	nucleus
0.56	GO:0150005	enzyme activator complex
0.56	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
0.48	GO:0032993	protein-DNA complex
0.43	GO:0044446	intracellular organelle part
0.35	GO:0031974	membrane-enclosed lumen
0.35	GO:0043232	intracellular non-membrane-bounded organelle
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0044444	cytoplasmic part

0.55

EC:2.1.1

GO:0008168

sp|P29376|LTK_HUMAN
Leukocyte tyrosine kinase receptor
Search

LTK

0.66	Leukocyte tyrosine kinase receptor

0.78	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.66	GO:0000187	activation of MAPK activity
0.64	GO:0048699	generation of neurons
0.61	GO:0048468	cell development
0.54	GO:0090648	response to environmental enrichment
0.54	GO:0010666	positive regulation of cardiac muscle cell apoptotic process
0.52	GO:0036269	swimming behavior
0.52	GO:0060159	regulation of dopamine receptor signaling pathway
0.52	GO:0071300	cellular response to retinoic acid

0.80	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0042802	identical protein binding
0.35	GO:0004704	NF-kappaB-inducing kinase activity
0.33	GO:0030276	clathrin binding
0.33	GO:0035091	phosphatidylinositol binding

0.44	GO:0005887	integral component of plasma membrane
0.41	GO:0043234	protein complex
0.36	GO:0005622	intracellular
0.36	GO:0070062	extracellular exosome
0.34	GO:0044297	cell body
0.34	GO:0030424	axon
0.34	GO:0012505	endomembrane system

0.80

EC:2.7.10.1

GO:0004714

sp|P29377|S100G_HUMAN
Protein S100-G
Search

0.41	GO:0042127	regulation of cell proliferation
0.35	GO:0006486	protein glycosylation
0.35	GO:0050727	regulation of inflammatory response
0.35	GO:0045087	innate immune response
0.33	GO:0006468	protein phosphorylation

0.70	GO:0005509	calcium ion binding
0.54	GO:0046914	transition metal ion binding
0.51	GO:0005499	vitamin D binding
0.43	GO:0048306	calcium-dependent protein binding
0.36	GO:0035662	Toll-like receptor 4 binding
0.36	GO:0050544	arachidonic acid binding
0.36	GO:0008378	galactosyltransferase activity
0.36	GO:0050786	RAGE receptor binding
0.34	GO:0008017	microtubule binding
0.33	GO:0004672	protein kinase activity

0.62	GO:0016323	basolateral plasma membrane
0.62	GO:0016324	apical plasma membrane
0.33	GO:0005634	nucleus
0.32	GO:0005737	cytoplasm

0.36

GO:0008378

sp|P29400|CO4A5_HUMAN
Collagen alpha-5(IV) chain
Search

COL4A5

0.78	Collagen type IV alpha 5 transcript variant 2

0.61	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
0.60	GO:0007528	neuromuscular junction development
0.53	GO:0061304	retinal blood vessel morphogenesis
0.52	GO:0001569	branching involved in blood vessel morphogenesis
0.52	GO:0071711	basement membrane organization
0.51	GO:0061333	renal tubule morphogenesis
0.50	GO:0071230	cellular response to amino acid stimulus
0.48	GO:0007420	brain development
0.38	GO:0030855	epithelial cell differentiation
0.37	GO:0030574	collagen catabolic process

0.80	GO:0005201	extracellular matrix structural constituent
0.53	GO:0048407	platelet-derived growth factor binding
0.36	GO:0097493	structural molecule activity conferring elasticity

0.80	GO:0005604	basement membrane
0.77	GO:0005581	collagen trimer
0.63	GO:0098645	collagen network
0.52	GO:0031594	neuromuscular junction
0.46	GO:0005615	extracellular space
0.37	GO:0005788	endoplasmic reticulum lumen

sp|P29401|TKT_HUMAN
Transketolase
Search

TKT

0.46	Transketolase

0.57	GO:0046166	glyceraldehyde-3-phosphate biosynthetic process
0.51	GO:0040008	regulation of growth
0.37	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA
0.36	GO:0009052	pentose-phosphate shunt, non-oxidative branch
0.36	GO:0005999	xylulose biosynthetic process
0.36	GO:0043085	positive regulation of catalytic activity
0.33	GO:0046390	ribose phosphate biosynthetic process

0.53	GO:0004802	transketolase activity
0.50	GO:0042803	protein homodimerization activity
0.41	GO:0048037	cofactor binding
0.36	GO:0008047	enzyme activator activity
0.35	GO:0046872	metal ion binding
0.34	GO:0048029	monosaccharide binding
0.34	GO:1901681	sulfur compound binding
0.33	GO:0019842	vitamin binding
0.32	GO:0043168	anion binding
0.32	GO:1901363	heterocyclic compound binding

0.53	GO:0043209	myelin sheath
0.52	GO:0016607	nuclear speck
0.36	GO:0070062	extracellular exosome
0.36	GO:0005777	peroxisome
0.34	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0005829	cytosol

0.53

EC:2.2.1.1

GO:0004802

sp|P29459|IL12A_HUMAN
Interleukin-12 subunit alpha
Search

IL12A

0.97	Interleukin-12 subunit alpha

0.76	GO:0010469	regulation of receptor activity
0.74	GO:0006955	immune response
0.66	GO:0051135	positive regulation of NK T cell activation
0.66	GO:0002857	positive regulation of natural killer cell mediated immune response to tumor cell
0.66	GO:0002858	regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
0.66	GO:2000510	positive regulation of dendritic cell chemotaxis
0.65	GO:0034393	positive regulation of smooth muscle cell apoptotic process
0.65	GO:0001916	positive regulation of T cell mediated cytotoxicity
0.65	GO:0032700	negative regulation of interleukin-17 production
0.65	GO:0032816	positive regulation of natural killer cell activation

0.87	GO:0005143	interleukin-12 receptor binding
0.80	GO:0005125	cytokine activity
0.78	GO:0008083	growth factor activity
0.71	GO:0042163	interleukin-12 beta subunit binding
0.69	GO:0019975	interleukin-17 binding
0.58	GO:0046982	protein heterodimerization activity

0.73	GO:0005615	extracellular space
0.48	GO:0043234	protein complex
0.40	GO:0031904	endosome lumen
0.39	GO:0005788	endoplasmic reticulum lumen
0.37	GO:0005770	late endosome
0.36	GO:0005796	Golgi lumen

sp|P29460|IL12B_HUMAN
Interleukin-12 subunit beta
Search

IL12B

0.96	Interleukin-12 subunit beta

0.78	GO:0019221	cytokine-mediated signaling pathway
0.74	GO:0010469	regulation of receptor activity
0.65	GO:0010536	positive regulation of activation of Janus kinase activity
0.65	GO:0051140	regulation of NK T cell proliferation
0.65	GO:0032819	positive regulation of natural killer cell proliferation
0.65	GO:0051135	positive regulation of NK T cell activation
0.64	GO:0002857	positive regulation of natural killer cell mediated immune response to tumor cell
0.64	GO:0002858	regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
0.64	GO:0042104	positive regulation of activated T cell proliferation
0.64	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production

0.80	GO:0004896	cytokine receptor activity
0.79	GO:0005125	cytokine activity
0.67	GO:0042164	interleukin-12 alpha subunit binding
0.66	GO:0045519	interleukin-23 receptor binding
0.57	GO:0008083	growth factor activity
0.55	GO:0046982	protein heterodimerization activity
0.54	GO:0042802	identical protein binding
0.39	GO:0005143	interleukin-12 receptor binding

0.72	GO:0005615	extracellular space
0.47	GO:0043234	protein complex
0.40	GO:0005737	cytoplasm
0.36	GO:0097708	intracellular vesicle
0.35	GO:0012505	endomembrane system
0.35	GO:0070013	intracellular organelle lumen
0.34	GO:0044446	intracellular organelle part
0.34	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016020	membrane

sp|P29466|CASP1_HUMAN
Caspase-1
Search

CASP1

0.87	Caspase 4, apoptosis-related cysteine peptidase

0.69	GO:0042981	regulation of apoptotic process
0.60	GO:0006508	proteolysis
0.56	GO:0012501	programmed cell death
0.55	GO:0050727	regulation of inflammatory response
0.55	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway
0.53	GO:0050706	regulation of interleukin-1 beta secretion
0.52	GO:0050716	positive regulation of interleukin-1 secretion
0.52	GO:0032731	positive regulation of interleukin-1 beta production
0.51	GO:0071260	cellular response to mechanical stimulus
0.50	GO:0071310	cellular response to organic substance

0.74	GO:0004197	cysteine-type endopeptidase activity
0.54	GO:0050700	CARD domain binding
0.47	GO:0019900	kinase binding
0.46	GO:0042802	identical protein binding
0.37	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
0.36	GO:0002020	protease binding
0.35	GO:0097110	scaffold protein binding
0.35	GO:0004869	cysteine-type endopeptidase inhibitor activity

0.62	GO:0097169	AIM2 inflammasome complex
0.62	GO:0072559	NLRP3 inflammasome complex
0.61	GO:0072557	IPAF inflammasome complex
0.56	GO:0072558	NLRP1 inflammasome complex
0.52	GO:0097179	protease inhibitor complex
0.42	GO:0005783	endoplasmic reticulum
0.41	GO:0005576	extracellular region
0.41	GO:0005739	mitochondrion
0.35	GO:0005886	plasma membrane
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network

0.74

EC:3.4.22

GO:0004197

sp|P29474|NOS3_HUMAN
Nitric oxide synthase, endothelial
Search

NOS3

0.72	Nitric oxide synthase

0.84	GO:0006809	nitric oxide biosynthetic process
0.61	GO:0031284	positive regulation of guanylate cyclase activity
0.61	GO:0043267	negative regulation of potassium ion transport
0.61	GO:0002026	regulation of the force of heart contraction
0.61	GO:0014900	muscle hyperplasia
0.60	GO:0014740	negative regulation of muscle hyperplasia
0.60	GO:0014805	smooth muscle adaptation
0.60	GO:0050880	regulation of blood vessel size
0.59	GO:0051926	negative regulation of calcium ion transport
0.59	GO:0002028	regulation of sodium ion transport

0.84	GO:0004517	nitric-oxide synthase activity
0.77	GO:0005516	calmodulin binding
0.70	GO:0010181	FMN binding
0.68	GO:0050661	NADP binding
0.64	GO:0050660	flavin adenine dinucleotide binding
0.62	GO:0020037	heme binding
0.61	GO:0005506	iron ion binding
0.60	GO:0034617	tetrahydrobiopterin binding
0.57	GO:0097110	scaffold protein binding
0.55	GO:0003785	actin monomer binding

0.60	GO:0005901	caveola
0.47	GO:0005634	nucleus
0.46	GO:0042383	sarcolemma
0.45	GO:0033017	sarcoplasmic reticulum membrane
0.44	GO:0030018	Z disc
0.44	GO:0005856	cytoskeleton
0.43	GO:0045202	synapse
0.41	GO:0070013	intracellular organelle lumen
0.40	GO:0005794	Golgi apparatus
0.39	GO:0005739	mitochondrion

0.84

EC:1.14.13.39

GO:0004517

sp|P29475|NOS1_HUMAN
Nitric oxide synthase, brain
Search

NOS1

0.72	Neuronal nitric oxide synthase

0.84	GO:0006809	nitric oxide biosynthetic process
0.57	GO:0098924	retrograde trans-synaptic signaling by nitric oxide
0.57	GO:1901206	positive regulation of adrenergic receptor signaling pathway involved in heart process
0.57	GO:0051612	negative regulation of serotonin uptake
0.56	GO:0097755	positive regulation of blood vessel diameter
0.56	GO:0042738	exogenous drug catabolic process
0.56	GO:0098735	positive regulation of the force of heart contraction
0.56	GO:0018119	peptidyl-cysteine S-nitrosylation
0.55	GO:0007263	nitric oxide mediated signal transduction
0.54	GO:0043267	negative regulation of potassium ion transport

0.84	GO:0004517	nitric-oxide synthase activity
0.77	GO:0005516	calmodulin binding
0.70	GO:0010181	FMN binding
0.68	GO:0050661	NADP binding
0.65	GO:0050660	flavin adenine dinucleotide binding
0.62	GO:0020037	heme binding
0.62	GO:0005506	iron ion binding
0.47	GO:0003958	NADPH-hemoprotein reductase activity
0.38	GO:0046870	cadmium ion binding
0.38	GO:0017080	sodium channel regulator activity

0.54	GO:0030315	T-tubule
0.53	GO:0033017	sarcoplasmic reticulum membrane
0.52	GO:0005901	caveola
0.52	GO:0030018	Z disc
0.49	GO:0045202	synapse
0.47	GO:0005654	nucleoplasm
0.46	GO:0005856	cytoskeleton
0.43	GO:0005739	mitochondrion
0.40	GO:0044309	neuron spine
0.39	GO:0036477	somatodendritic compartment

0.84

EC:1.14.13.39

GO:0004517

sp|P29508|SPB3_HUMAN
Serpin B3
Search

SERPINB13

0.97	Squamous cell carcinoma antigen 2

0.54	GO:0010951	negative regulation of endopeptidase activity
0.43	GO:0042270	protection from natural killer cell mediated cytotoxicity
0.42	GO:0035425	autocrine signaling
0.41	GO:0038001	paracrine signaling
0.41	GO:0043508	negative regulation of JUN kinase activity
0.40	GO:0010718	positive regulation of epithelial to mesenchymal transition
0.40	GO:0010950	positive regulation of endopeptidase activity
0.39	GO:1902173	negative regulation of keratinocyte apoptotic process
0.39	GO:0030335	positive regulation of cell migration
0.39	GO:0008284	positive regulation of cell proliferation

0.55	GO:0004867	serine-type endopeptidase inhibitor activity
0.46	GO:0002020	protease binding
0.44	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.41	GO:0104005	hijacked molecular function
0.34	GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process
0.32	GO:0008233	peptidase activity

0.73	GO:0005615	extracellular space
0.47	GO:0016607	nuclear speck
0.43	GO:0005829	cytosol
0.42	GO:1903561	extracellular vesicle
0.38	GO:0031410	cytoplasmic vesicle
0.38	GO:0005775	vacuolar lumen
0.36	GO:0005764	lysosome
0.36	GO:0031983	vesicle lumen
0.35	GO:0005730	nucleolus
0.35	GO:0012505	endomembrane system

0.32

GO:0008233

sp|P29536|LMOD1_HUMAN
Leiomodin-1
Search

LMOD1

0.97	Leiomodin 1 (Smooth muscle)

0.85	GO:0051694	pointed-end actin filament capping
0.80	GO:0006936	muscle contraction
0.58	GO:0045010	actin nucleation
0.52	GO:0030239	myofibril assembly
0.41	GO:0030041	actin filament polymerization

0.85	GO:0005523	tropomyosin binding
0.69	GO:0003779	actin binding
0.33	GO:0003677	DNA binding

0.59	GO:0030016	myofibril
0.51	GO:0044449	contractile fiber part
0.50	GO:0005829	cytosol
0.48	GO:0015629	actin cytoskeleton
0.47	GO:0044430	cytoskeletal part
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P29558|RBMS1_HUMAN
RNA-binding motif, single-stranded-interacting protein 1
Search

RBMS1

0.95	RNA binding motif single stranded interacting protein 1

0.36	GO:0006260	DNA replication
0.33	GO:0006396	RNA processing

0.59	GO:0003723	RNA binding
0.34	GO:0003677	DNA binding
0.33	GO:0005515	protein binding

0.47	GO:0005829	cytosol
0.35	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|P29590|PML_HUMAN
Protein PML
Search

PML

0.97	Promyelocytic leukemia

0.73	GO:0016525	negative regulation of angiogenesis
0.73	GO:0030308	negative regulation of cell growth
0.71	GO:0001666	response to hypoxia
0.70	GO:0030578	PML body organization
0.69	GO:0045345	positive regulation of MHC class I biosynthetic process
0.68	GO:0050713	negative regulation of interleukin-1 beta secretion
0.68	GO:0007182	common-partner SMAD protein phosphorylation
0.68	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.67	GO:0010761	fibroblast migration
0.67	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

0.67	GO:0032183	SUMO binding
0.64	GO:0046332	SMAD binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0031625	ubiquitin protein ligase binding
0.58	GO:0042803	protein homodimerization activity

0.74	GO:0016605	PML body
0.66	GO:0042406	extrinsic component of endoplasmic reticulum membrane
0.64	GO:0005730	nucleolus
0.64	GO:0016363	nuclear matrix
0.62	GO:0000784	nuclear chromosome, telomeric region
0.62	GO:0000792	heterochromatin
0.54	GO:0005829	cytosol

sp|P29597|TYK2_HUMAN
Non-receptor tyrosine-protein kinase TYK2
Search

TYK2

0.59	Tyrosine-protein kinase

0.75	GO:0018108	peptidyl-tyrosine phosphorylation
0.61	GO:0035556	intracellular signal transduction
0.47	GO:0046777	protein autophosphorylation
0.46	GO:0045087	innate immune response
0.46	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.45	GO:0016477	cell migration
0.45	GO:0042127	regulation of cell proliferation
0.43	GO:0030154	cell differentiation
0.38	GO:0038110	interleukin-2-mediated signaling pathway
0.38	GO:1903672	positive regulation of sprouting angiogenesis

0.79	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.56	GO:0005131	growth hormone receptor binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0031702	type 1 angiotensin receptor binding
0.38	GO:0097677	STAT family protein binding
0.37	GO:0019903	protein phosphatase binding
0.36	GO:0031625	ubiquitin protein ligase binding
0.33	GO:0003723	RNA binding

0.67	GO:0005856	cytoskeleton
0.46	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.45	GO:0005634	nucleus
0.39	GO:0005737	cytoplasm
0.35	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.79

GO:0004715

sp|P29622|KAIN_HUMAN
Kallistatin
Search

SERPINA4

0.80	Thyroxine-binding globulin

0.52	GO:0010951	negative regulation of endopeptidase activity
0.41	GO:0070327	thyroid hormone transport
0.40	GO:0043434	response to peptide hormone
0.38	GO:0034097	response to cytokine
0.36	GO:0002576	platelet degranulation
0.36	GO:0006508	proteolysis
0.35	GO:0033273	response to vitamin
0.35	GO:0051384	response to glucocorticoid
0.35	GO:0006954	inflammatory response
0.34	GO:0051385	response to mineralocorticoid

0.53	GO:0004867	serine-type endopeptidase inhibitor activity
0.36	GO:0008233	peptidase activity
0.36	GO:0002020	protease binding
0.34	GO:0032190	acrosin binding
0.34	GO:0042802	identical protein binding
0.34	GO:0015349	thyroid hormone transmembrane transporter activity
0.34	GO:0001972	retinoic acid binding
0.34	GO:0031210	phosphatidylcholine binding
0.34	GO:0042562	hormone binding
0.34	GO:0008201	heparin binding

0.73	GO:0005615	extracellular space
0.38	GO:1903561	extracellular vesicle
0.37	GO:0030141	secretory granule
0.36	GO:0060205	cytoplasmic vesicle lumen
0.34	GO:0097182	protein C inhibitor-coagulation factor Xa complex
0.34	GO:0097183	protein C inhibitor-coagulation factor XI complex
0.34	GO:0097181	protein C inhibitor-coagulation factor V complex
0.34	GO:0036030	protein C inhibitor-plasma kallikrein complex
0.34	GO:0036028	protein C inhibitor-thrombin complex
0.34	GO:0036029	protein C inhibitor-KLK3 complex

0.36

GO:0008233

sp|P29692|EF1D_HUMAN
Elongation factor 1-delta
Search

EEF1D

0.83	Eukaryotic translation elongation factor 1 delta transcript variant 1

0.69	GO:0006414	translational elongation
0.50	GO:0071479	cellular response to ionizing radiation
0.40	GO:0009299	mRNA transcription
0.37	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.37	GO:0010941	regulation of cell death
0.35	GO:2001141	regulation of RNA biosynthetic process
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0010468	regulation of gene expression
0.34	GO:0007165	signal transduction

0.69	GO:0003746	translation elongation factor activity
0.48	GO:0045296	cadherin binding
0.39	GO:0033613	activating transcription factor binding
0.38	GO:0031072	heat shock protein binding
0.35	GO:0003677	DNA binding
0.35	GO:0004871	signal transducer activity

0.82	GO:0005853	eukaryotic translation elongation factor 1 complex
0.48	GO:0001650	fibrillar center
0.44	GO:0005783	endoplasmic reticulum
0.44	GO:0005829	cytosol

sp|P29728|OAS2_HUMAN
2'-5'-oligoadenylate synthase 2
Search

0.66	2'-5'-oligoadenylate synthetase 3

0.78	GO:0051607	defense response to virus
0.74	GO:0006955	immune response
0.48	GO:0048525	negative regulation of viral process
0.47	GO:0045069	regulation of viral genome replication
0.40	GO:0042593	glucose homeostasis
0.40	GO:0006164	purine nucleotide biosynthetic process
0.39	GO:0060700	regulation of ribonuclease activity
0.39	GO:0006006	glucose metabolic process
0.38	GO:0018377	protein myristoylation
0.37	GO:0035457	cellular response to interferon-alpha

0.77	GO:0003725	double-stranded RNA binding
0.60	GO:0016779	nucleotidyltransferase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0008270	zinc ion binding
0.34	GO:0005515	protein binding

0.41	GO:0005829	cytosol
0.38	GO:0005634	nucleus
0.37	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0005783	endoplasmic reticulum
0.35	GO:0031974	membrane-enclosed lumen
0.35	GO:0044446	intracellular organelle part
0.35	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.34	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.60

EC:2.7.7

GO:0016779

sp|P29762|RABP1_HUMAN
Cellular retinoic acid-binding protein 1
Search

CRABP1

0.93	Cellular retinoic acid binding protein I

0.85	GO:0042573	retinoic acid metabolic process
0.84	GO:0042363	fat-soluble vitamin catabolic process
0.84	GO:0016103	diterpenoid catabolic process
0.68	GO:0072329	monocarboxylic acid catabolic process
0.56	GO:0048385	regulation of retinoic acid receptor signaling pathway
0.49	GO:0048672	positive regulation of collateral sprouting
0.48	GO:0035115	embryonic forelimb morphogenesis
0.34	GO:0051260	protein homooligomerization
0.34	GO:0008544	epidermis development
0.34	GO:0007165	signal transduction

0.86	GO:0001972	retinoic acid binding
0.45	GO:0019841	retinol binding
0.44	GO:0016918	retinal binding
0.35	GO:0005515	protein binding
0.33	GO:0044877	macromolecular complex binding
0.32	GO:0005198	structural molecule activity

0.49	GO:0005737	cytoplasm
0.44	GO:0005634	nucleus
0.42	GO:0043233	organelle lumen
0.39	GO:0044446	intracellular organelle part
0.37	GO:0070852	cell body fiber
0.36	GO:0030424	axon
0.34	GO:0070062	extracellular exosome
0.34	GO:0045111	intermediate filament cytoskeleton
0.33	GO:0099512	supramolecular fiber
0.33	GO:0012505	endomembrane system

sp|P29803|ODPAT_HUMAN
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Search

PDHA1

0.52	Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

0.80	GO:0006086	acetyl-CoA biosynthetic process from pyruvate
0.52	GO:0055114	oxidation-reduction process
0.46	GO:0006101	citrate metabolic process
0.43	GO:0019362	pyridine nucleotide metabolic process
0.41	GO:0006091	generation of precursor metabolites and energy
0.41	GO:0006006	glucose metabolic process
0.37	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate

0.78	GO:0004738	pyruvate dehydrogenase activity
0.75	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
0.47	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.33	GO:0005515	protein binding

0.55	GO:0043231	intracellular membrane-bounded organelle
0.49	GO:0045254	pyruvate dehydrogenase complex
0.48	GO:0031974	membrane-enclosed lumen
0.47	GO:0043209	myelin sheath
0.43	GO:0044446	intracellular organelle part
0.43	GO:0043232	intracellular non-membrane-bounded organelle

0.75

EC:1.2.4

GO:0016624

sp|P29965|CD40L_HUMAN
CD40 ligand
Search

sp|P29966|MARCS_HUMAN
Myristoylated alanine-rich C-kinase substrate
Search

MARCKS

0.97	Myristoylated alanine-rich protein kinase C substrate a

0.60	GO:0051764	actin crosslink formation
0.57	GO:0051017	actin filament bundle assembly
0.55	GO:0051260	protein homooligomerization
0.48	GO:0010842	retina layer formation
0.47	GO:0035914	skeletal muscle cell differentiation
0.46	GO:0007420	brain development
0.46	GO:0060541	respiratory system development
0.43	GO:0016310	phosphorylation
0.42	GO:0003381	epithelial cell morphogenesis involved in gastrulation
0.41	GO:0060027	convergent extension involved in gastrulation

0.79	GO:0005516	calmodulin binding
0.60	GO:0005080	protein kinase C binding
0.55	GO:0051015	actin filament binding
0.52	GO:0042802	identical protein binding
0.45	GO:0016301	kinase activity
0.37	GO:0001786	phosphatidylserine binding
0.32	GO:0042954	lipoprotein transporter activity

0.62	GO:0042585	germinal vesicle
0.58	GO:0032432	actin filament bundle
0.55	GO:0005813	centrosome
0.53	GO:0005938	cell cortex
0.41	GO:0070062	extracellular exosome
0.40	GO:0005925	focal adhesion
0.38	GO:0044307	dendritic branch
0.38	GO:0005886	plasma membrane
0.38	GO:0032059	bleb
0.38	GO:0001520	outer dense fiber

sp|P29972|AQP1_HUMAN
Aquaporin-1
Search

AQP1

0.89	Aquaporin 1, Colton blood group antigen

0.59	GO:0085018	maintenance of symbiont-containing vacuole by host
0.57	GO:0003097	renal water transport
0.57	GO:0072230	metanephric proximal straight tubule development
0.57	GO:0072232	metanephric proximal convoluted tubule segment 2 development
0.57	GO:0072220	metanephric descending thin limb development
0.57	GO:0021670	lateral ventricle development
0.57	GO:0051458	corticotropin secretion
0.55	GO:0072239	metanephric glomerulus vasculature development
0.55	GO:0044241	lipid digestion
0.55	GO:0055085	transmembrane transport

0.69	GO:0022803	passive transmembrane transporter activity
0.56	GO:0005372	water transmembrane transporter activity
0.54	GO:0035379	carbon dioxide transmembrane transporter activity
0.53	GO:0046875	ephrin receptor binding
0.49	GO:0015079	potassium ion transmembrane transporter activity
0.49	GO:0030184	nitric oxide transmembrane transporter activity
0.47	GO:0015168	glycerol transmembrane transporter activity
0.47	GO:0008519	ammonium transmembrane transporter activity
0.39	GO:0042802	identical protein binding

0.56	GO:0020003	symbiont-containing vacuole
0.55	GO:0009925	basal plasma membrane
0.54	GO:0005903	brush border
0.53	GO:0016324	apical plasma membrane
0.52	GO:0005901	caveola
0.51	GO:0070062	extracellular exosome
0.51	GO:0030424	axon
0.45	GO:0042383	sarcolemma
0.44	GO:0031253	cell projection membrane
0.44	GO:0031965	nuclear membrane

sp|P29973|CNGA1_HUMAN
cGMP-gated cation channel alpha-1
Search

CNGA1

0.97	Cyclic nucleotide-gated channel rod photoreceptor subunit alpha

0.73	GO:0007601	visual perception
0.60	GO:0034220	ion transmembrane transport
0.59	GO:0006812	cation transport
0.46	GO:0042391	regulation of membrane potential
0.36	GO:0022400	regulation of rhodopsin mediated signaling pathway
0.35	GO:0016056	rhodopsin mediated signaling pathway
0.35	GO:0051480	regulation of cytosolic calcium ion concentration
0.34	GO:0007283	spermatogenesis
0.32	GO:0006355	regulation of transcription, DNA-templated

0.83	GO:0005221	intracellular cyclic nucleotide activated cation channel activity
0.50	GO:0005249	voltage-gated potassium channel activity
0.43	GO:0030553	cGMP binding
0.34	GO:0030552	cAMP binding
0.33	GO:0005515	protein binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0003700	DNA binding transcription factor activity

0.52	GO:0042622	photoreceptor outer segment membrane
0.42	GO:0005887	integral component of plasma membrane
0.36	GO:1902495	transmembrane transporter complex
0.35	GO:0043195	terminal bouton
0.33	GO:0005634	nucleus
0.32	GO:0005737	cytoplasm

sp|P29992|GNA11_HUMAN
Guanine nucleotide-binding protein subunit alpha-11
Search

GNA11

0.76	G protein subunit alpha q

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.55	GO:0007603	phototransduction, visible light
0.55	GO:0009649	entrainment of circadian clock
0.54	GO:0001508	action potential
0.54	GO:0045634	regulation of melanocyte differentiation
0.54	GO:1905145	cellular response to acetylcholine
0.54	GO:1903831	signal transduction involved in cellular response to ammonium ion
0.51	GO:0048066	developmental pigmentation
0.50	GO:0071467	cellular response to pH
0.50	GO:0001501	skeletal system development

0.81	GO:0031683	G-protein beta/gamma-subunit complex binding
0.80	GO:0001664	G-protein coupled receptor binding
0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.64	GO:0004871	signal transducer activity
0.38	GO:0005096	GTPase activator activity
0.38	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity
0.36	GO:0046872	metal ion binding
0.35	GO:0002046	opsin binding
0.33	GO:0042626	ATPase activity, coupled to transmembrane movement of substances

0.55	GO:0001750	photoreceptor outer segment
0.45	GO:1905360	GTPase complex
0.44	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.40	GO:0098797	plasma membrane protein complex
0.38	GO:0030425	dendrite
0.38	GO:0044297	cell body
0.37	GO:0005765	lysosomal membrane
0.36	GO:0031982	vesicle
0.36	GO:0043230	extracellular organelle
0.35	GO:0005615	extracellular space

0.38

EC:3.1.4.39

GO:0047391

sp|P30038|AL4A1_HUMAN
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Search

ALDH4A1

0.59	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

0.78	GO:0010133	proline catabolic process to glutamate
0.53	GO:0055114	oxidation-reduction process
0.36	GO:0007005	mitochondrion organization
0.36	GO:0019470	4-hydroxyproline catabolic process
0.35	GO:0046487	glyoxylate metabolic process
0.34	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0006091	generation of precursor metabolites and energy

0.79	GO:0003842	1-pyrroline-5-carboxylate dehydrogenase activity
0.69	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.47	GO:0042802	identical protein binding
0.34	GO:0004930	G-protein coupled receptor activity
0.33	GO:0009055	electron transfer activity

0.43	GO:0005739	mitochondrion
0.37	GO:0031974	membrane-enclosed lumen
0.35	GO:0044446	intracellular organelle part
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:1.5.1.12

GO:0003842

sp|P30039|PBLD_HUMAN
Phenazine biosynthesis-like domain-containing protein
Search

PBLD

0.97	Phenazine biosynthesis like protein domain containing

0.60	GO:0060392	negative regulation of SMAD protein import into nucleus
0.59	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
0.58	GO:0030277	maintenance of gastrointestinal epithelium
0.58	GO:0010719	negative regulation of epithelial to mesenchymal transition
0.56	GO:0010633	negative regulation of epithelial cell migration
0.56	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.56	GO:0050680	negative regulation of epithelial cell proliferation
0.49	GO:0009058	biosynthetic process
0.34	GO:0003407	neural retina development
0.32	GO:2001141	regulation of RNA biosynthetic process

0.51	GO:0042802	identical protein binding
0.39	GO:0016853	isomerase activity
0.33	GO:0046983	protein dimerization activity
0.32	GO:0003723	RNA binding
0.32	GO:0008080	N-acetyltransferase activity

0.39	GO:0005737	cytoplasm
0.37	GO:0070062	extracellular exosome
0.33	GO:0019013	viral nucleocapsid
0.32	GO:0030529	intracellular ribonucleoprotein complex

0.39

EC:5

GO:0016853

sp|P30040|ERP29_HUMAN
Endoplasmic reticulum resident protein 29
Search

ERP29

0.97	Endoplasmic reticulum resident protein 29

0.70	GO:0009306	protein secretion
0.67	GO:0000187	activation of MAPK activity
0.67	GO:0050709	negative regulation of protein secretion
0.63	GO:1902235	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.58	GO:0010628	positive regulation of gene expression
0.55	GO:0010629	negative regulation of gene expression
0.48	GO:0006886	intracellular protein transport
0.48	GO:0006457	protein folding
0.37	GO:0043335	protein unfolding
0.37	GO:0034976	response to endoplasmic reticulum stress

0.42	GO:0051087	chaperone binding
0.42	GO:0042803	protein homodimerization activity
0.37	GO:0003756	protein disulfide isomerase activity
0.34	GO:0016887	ATPase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.84	GO:0005788	endoplasmic reticulum lumen
0.71	GO:0042470	melanosome
0.61	GO:0009986	cell surface
0.45	GO:0005790	smooth endoplasmic reticulum
0.42	GO:0030133	transport vesicle
0.40	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.37

EC:5.3.4.1

GO:0003756

sp|P30041|PRDX6_HUMAN
Peroxiredoxin-6
Search

PRDX6

0.88	Epididymis secretory sperm binding protein Li 128m

0.69	GO:0098869	cellular oxidant detoxification
0.68	GO:0045454	cell redox homeostasis
0.54	GO:0048026	positive regulation of mRNA splicing, via spliceosome
0.53	GO:0046475	glycerophospholipid catabolic process
0.53	GO:0055114	oxidation-reduction process
0.47	GO:0006979	response to oxidative stress
0.37	GO:0032060	bleb assembly
0.37	GO:0042744	hydrogen peroxide catabolic process
0.36	GO:1901700	response to oxygen-containing compound
0.35	GO:0043312	neutrophil degranulation

0.74	GO:0051920	peroxiredoxin activity
0.56	GO:0047499	calcium-independent phospholipase A2 activity
0.52	GO:0045296	cadherin binding
0.51	GO:0004602	glutathione peroxidase activity
0.51	GO:0031625	ubiquitin protein ligase binding
0.49	GO:0042803	protein homodimerization activity
0.43	GO:0102568	phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
0.43	GO:0102567	phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)

0.51	GO:0048471	perinuclear region of cytoplasm
0.43	GO:0005634	nucleus
0.41	GO:0005764	lysosome
0.37	GO:0005615	extracellular space
0.36	GO:0005829	cytosol
0.36	GO:1903561	extracellular vesicle
0.35	GO:0034774	secretory granule lumen
0.35	GO:0005775	vacuolar lumen
0.34	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.74

EC:1.11.1.15

GO:0051920

sp|P30042|ES1_HUMAN
ES1 protein homolog, mitochondrial
Search

0.48	ES1 protein like protein, mitochondrial

0.39	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.37	GO:0006959	humoral immune response
0.36	GO:0006417	regulation of translation
0.36	GO:0006914	autophagy
0.36	GO:0006468	protein phosphorylation
0.34	GO:0006541	glutamine metabolic process

0.43	GO:0016829	lyase activity
0.39	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
0.37	GO:0045182	translation regulator activity
0.36	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0003677	DNA binding
0.34	GO:0046872	metal ion binding

0.57	GO:0005739	mitochondrion
0.35	GO:0031967	organelle envelope
0.35	GO:0031090	organelle membrane
0.35	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.43

EC:4

GO:0016829

sp|P30043|BLVRB_HUMAN
Flavin reductase (NADPH)
Search

BLVRB

0.45	Biliverdin reductase B

0.84	GO:0042167	heme catabolic process
0.51	GO:0055114	oxidation-reduction process
0.38	GO:0000183	chromatin silencing at rDNA

0.85	GO:0004074	biliverdin reductase activity
0.83	GO:0042602	riboflavin reductase (NADPH) activity
0.34	GO:0003677	DNA binding

0.67	GO:0005654	nucleoplasm
0.66	GO:0005829	cytosol
0.54	GO:0005886	plasma membrane
0.53	GO:0043195	terminal bouton
0.43	GO:0070062	extracellular exosome
0.38	GO:0005720	nuclear heterochromatin
0.30	GO:0031224	intrinsic component of membrane

0.85	EC:1.3.1.24	GO:0004074
0.83	KEGG:R05707	GO:0042602

sp|P30044|PRDX5_HUMAN
Peroxiredoxin-5, mitochondrial
Search

PRDX5

0.94	Mitochondrial peroxiredoxin 5

0.68	GO:0045454	cell redox homeostasis
0.53	GO:0055114	oxidation-reduction process
0.52	GO:0016480	negative regulation of transcription by RNA polymerase III
0.52	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.49	GO:0006915	apoptotic process
0.48	GO:0034614	cellular response to reactive oxygen species
0.47	GO:0098869	cellular oxidant detoxification
0.44	GO:0031101	fin regeneration
0.40	GO:0060785	regulation of apoptosis involved in tissue homeostasis
0.39	GO:0010714	positive regulation of collagen metabolic process

0.54	GO:0016491	oxidoreductase activity
0.53	GO:0001016	RNA polymerase III regulatory region DNA binding
0.53	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.47	GO:0016209	antioxidant activity
0.47	GO:0005102	receptor binding
0.45	GO:0046983	protein dimerization activity
0.34	GO:0003707	steroid hormone receptor activity
0.34	GO:0051082	unfolded protein binding
0.33	GO:0043565	sequence-specific DNA binding
0.33	GO:0008270	zinc ion binding

0.50	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0005777	peroxisome
0.47	GO:0031410	cytoplasmic vesicle
0.46	GO:0005829	cytosol
0.43	GO:0005739	mitochondrion
0.43	GO:0005634	nucleus
0.42	GO:0031907	microbody lumen
0.37	GO:0070062	extracellular exosome

0.54

GO:0016491

sp|P30046|DOPD_HUMAN
D-dopachrome decarboxylase
Search

DDT

0.97	D-dopachrome tautomerase like

0.76	GO:0050729	positive regulation of inflammatory response
0.60	GO:0042438	melanin biosynthetic process
0.52	GO:0010760	negative regulation of macrophage chemotaxis
0.50	GO:0032760	positive regulation of tumor necrosis factor production
0.49	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.46	GO:0048839	inner ear development
0.45	GO:0043066	negative regulation of apoptotic process
0.40	GO:0006954	inflammatory response
0.39	GO:0006336	DNA replication-independent nucleosome assembly
0.37	GO:0006749	glutathione metabolic process

0.75	GO:0002020	protease binding
0.67	GO:0033981	D-dopachrome decarboxylase activity
0.52	GO:0050178	phenylpyruvate tautomerase activity
0.49	GO:0004167	dopachrome isomerase activity
0.47	GO:0005126	cytokine receptor binding
0.38	GO:0004364	glutathione transferase activity

0.68	GO:0005615	extracellular space
0.48	GO:1903561	extracellular vesicle
0.41	GO:0005737	cytoplasm

0.67	EC:4.1.1.84	GO:0033981
0.67	KEGG:R07313	GO:0033981

sp|P30047|GFRP_HUMAN
GTP cyclohydrolase 1 feedback regulatory protein
Search

GCHFR

0.97	GTP cyclohydrolase I feedback regulator

0.69	GO:0009890	negative regulation of biosynthetic process
0.43	GO:0043105	negative regulation of GTP cyclohydrolase I activity
0.41	GO:0051291	protein heterooligomerization
0.36	GO:0001505	regulation of neurotransmitter levels
0.35	GO:1903426	regulation of reactive oxygen species biosynthetic process
0.35	GO:1903409	reactive oxygen species biosynthetic process
0.35	GO:2001057	reactive nitrogen species metabolic process
0.33	GO:0051186	cofactor metabolic process
0.33	GO:0017144	drug metabolic process
0.33	GO:0031326	regulation of cellular biosynthetic process

0.47	GO:0016787	hydrolase activity
0.43	GO:0044549	GTP cyclohydrolase binding
0.41	GO:0030742	GTP-dependent protein binding
0.39	GO:0016597	amino acid binding
0.38	GO:0004857	enzyme inhibitor activity

0.57	GO:0042470	melanosome
0.55	GO:0031965	nuclear membrane
0.55	GO:0030425	dendrite
0.50	GO:0005654	nucleoplasm
0.39	GO:0005829	cytosol
0.36	GO:0043234	protein complex

0.47

GO:0016787

sp|P30048|PRDX3_HUMAN
Thioredoxin-dependent peroxide reductase, mitochondrial
Search

PRDX3

0.93	Thioredoxin-dependent peroxide reductase

0.69	GO:0098869	cellular oxidant detoxification
0.68	GO:0045454	cell redox homeostasis
0.55	GO:0018171	peptidyl-cysteine oxidation
0.53	GO:0051881	regulation of mitochondrial membrane potential
0.52	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.52	GO:0042542	response to hydrogen peroxide
0.52	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.51	GO:0001893	maternal placenta development
0.51	GO:0030099	myeloid cell differentiation
0.51	GO:0032496	response to lipopolysaccharide

0.74	GO:0051920	peroxiredoxin activity
0.54	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.52	GO:0008022	protein C-terminus binding
0.50	GO:0019901	protein kinase binding
0.48	GO:0004601	peroxidase activity
0.48	GO:0042802	identical protein binding
0.35	GO:0015075	ion transmembrane transporter activity
0.35	GO:0008785	alkyl hydroperoxide reductase activity

0.54	GO:0008385	IkappaB kinase complex
0.51	GO:0043209	myelin sheath
0.50	GO:0005769	early endosome
0.43	GO:0005739	mitochondrion
0.42	GO:0043234	protein complex
0.36	GO:0070062	extracellular exosome
0.35	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.74	EC:1.11.1.15	GO:0051920
0.48	KEGG:R03532	GO:0004601

sp|P30049|ATPD_HUMAN
ATP synthase subunit delta, mitochondrial
Search

ATP5D

0.45	Mitochondrial ATP synthase subunit delta

0.70	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.70	GO:0006754	ATP biosynthetic process
0.69	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.36	GO:0042407	cristae formation
0.35	GO:0046688	response to copper ion
0.35	GO:0006839	mitochondrial transport
0.34	GO:0046907	intracellular transport
0.34	GO:0006119	oxidative phosphorylation
0.33	GO:0055114	oxidation-reduction process

0.72	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
0.35	GO:0043531	ADP binding
0.34	GO:0032403	protein complex binding
0.34	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
0.33	GO:0005524	ATP binding

0.72	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)
0.54	GO:0005753	mitochondrial proton-transporting ATP synthase complex
0.35	GO:0005759	mitochondrial matrix

0.34

EC:1.1.1

GO:0016616

sp|P30050|RL12_HUMAN
60S ribosomal protein L12
Search

RPL12

0.72	Alpha-tubulin N-acetyltransferase 1 (Fragment)

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.50	GO:0000027	ribosomal large subunit assembly
0.34	GO:0045901	positive regulation of translational elongation
0.34	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.34	GO:0019083	viral transcription
0.33	GO:0016072	rRNA metabolic process

0.64	GO:0003735	structural constituent of ribosome
0.45	GO:0019843	rRNA binding
0.34	GO:0005515	protein binding
0.32	GO:0016740	transferase activity

0.61	GO:0005840	ribosome
0.47	GO:0044445	cytosolic part
0.42	GO:0044446	intracellular organelle part
0.36	GO:0031012	extracellular matrix
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.35	GO:0043233	organelle lumen
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016740

sp|P30084|ECHM_HUMAN
Enoyl-CoA hydratase, mitochondrial
Search

ECHS1

0.38	Mitochondrial enoyl-CoA hydratase

0.52	GO:0006635	fatty acid beta-oxidation
0.33	GO:0005996	monosaccharide metabolic process

0.54	GO:0004300	enoyl-CoA hydratase activity
0.35	GO:0016508	long-chain-enoyl-CoA hydratase activity
0.33	GO:0048029	monosaccharide binding
0.33	GO:0005515	protein binding
0.32	GO:0016853	isomerase activity

0.45	GO:0005739	mitochondrion
0.37	GO:0043233	organelle lumen
0.36	GO:0070062	extracellular exosome
0.35	GO:0044446	intracellular organelle part
0.30	GO:0044425	membrane part

0.54

EC:4.2.1.17

GO:0004300

sp|P30085|KCY_HUMAN
UMP-CMP kinase
Search

CMPK1

0.82	Cytidine/uridine monophosphate kinase 1

0.73	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
0.68	GO:0006221	pyrimidine nucleotide biosynthetic process
0.68	GO:0046939	nucleotide phosphorylation
0.60	GO:0009132	nucleoside diphosphate metabolic process
0.49	GO:0009142	nucleoside triphosphate biosynthetic process
0.40	GO:0046940	nucleoside monophosphate phosphorylation
0.36	GO:0018963	phthalate metabolic process
0.35	GO:0015949	nucleobase-containing small molecule interconversion
0.35	GO:0046134	pyrimidine nucleoside biosynthetic process
0.35	GO:0009218	pyrimidine ribonucleotide metabolic process

0.78	GO:0004127	cytidylate kinase activity
0.78	GO:0009041	uridylate kinase activity
0.67	GO:0004550	nucleoside diphosphate kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0050145	nucleoside phosphate kinase activity
0.35	GO:0004849	uridine kinase activity

0.55	GO:0005634	nucleus
0.47	GO:0031974	membrane-enclosed lumen
0.45	GO:0005737	cytoplasm
0.43	GO:0043232	intracellular non-membrane-bounded organelle
0.43	GO:0044446	intracellular organelle part
0.36	GO:0070062	extracellular exosome

0.78

EC:2.7.4.14

GO:0004127

sp|P30086|PEBP1_HUMAN
Phosphatidylethanolamine-binding protein 1
Search

PEBP1

0.63	Phosphatidylethanolamine-binding protein 1

0.55	GO:0010951	negative regulation of endopeptidase activity
0.51	GO:0060409	positive regulation of acetylcholine metabolic process
0.51	GO:0048240	sperm capacitation
0.49	GO:0051412	response to corticosterone
0.49	GO:0010243	response to organonitrogen compound
0.48	GO:0043950	positive regulation of cAMP-mediated signaling
0.48	GO:0051602	response to electrical stimulus
0.48	GO:0042755	eating behavior
0.48	GO:0002026	regulation of the force of heart contraction
0.48	GO:0014823	response to activity

0.70	GO:0019901	protein kinase binding
0.56	GO:0004867	serine-type endopeptidase inhibitor activity
0.53	GO:0008289	lipid binding
0.44	GO:0032559	adenyl ribonucleotide binding
0.44	GO:0008144	drug binding
0.44	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0005102	receptor binding
0.40	GO:0019210	kinase inhibitor activity
0.38	GO:0003723	RNA binding

0.49	GO:0043209	myelin sheath
0.47	GO:0043679	axon terminus
0.46	GO:0009986	cell surface
0.46	GO:0005791	rough endoplasmic reticulum
0.46	GO:0008021	synaptic vesicle
0.46	GO:0043025	neuronal cell body
0.45	GO:0005615	extracellular space
0.45	GO:0045177	apical part of cell
0.44	GO:0005741	mitochondrial outer membrane
0.43	GO:1903561	extracellular vesicle

sp|P30101|PDIA3_HUMAN
Protein disulfide-isomerase A3
Search

PDIA3

0.57	Protein disulfide-isomerase A3

0.69	GO:0045454	cell redox homeostasis
0.67	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
0.64	GO:0034976	response to endoplasmic reticulum stress
0.53	GO:0006457	protein folding
0.52	GO:1904148	cellular response to nonylphenol
0.51	GO:1901423	response to benzene
0.51	GO:1903334	positive regulation of protein folding
0.51	GO:0033595	response to genistein
0.50	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.48	GO:0071305	cellular response to vitamin D

0.72	GO:0003756	protein disulfide isomerase activity
0.64	GO:0015037	peptide disulfide oxidoreductase activity
0.59	GO:0042802	identical protein binding
0.49	GO:0019153	protein-disulfide reductase (glutathione) activity
0.48	GO:0042288	MHC class I protein binding
0.46	GO:0004629	phospholipase C activity
0.44	GO:0004197	cysteine-type endopeptidase activity
0.43	GO:0003723	RNA binding

0.74	GO:0042470	melanosome
0.73	GO:0005788	endoplasmic reticulum lumen
0.64	GO:0043209	myelin sheath
0.63	GO:0009986	cell surface
0.58	GO:0005615	extracellular space
0.52	GO:0005925	focal adhesion
0.52	GO:1903561	extracellular vesicle
0.48	GO:0042825	TAP complex
0.48	GO:0005790	smooth endoplasmic reticulum
0.48	GO:0055038	recycling endosome membrane

0.72

EC:5.3.4.1

GO:0003756

sp|P30153|2AAA_HUMAN
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Search

0.86	Serine-threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha

0.74	GO:0043666	regulation of phosphoprotein phosphatase activity
0.65	GO:0006461	protein complex assembly
0.57	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
0.52	GO:0051232	meiotic spindle elongation
0.51	GO:1903538	regulation of meiotic cell cycle process involved in oocyte maturation
0.50	GO:0051306	mitotic sister chromatid separation
0.49	GO:0051754	meiotic sister chromatid cohesion, centromeric
0.49	GO:0070262	peptidyl-serine dephosphorylation
0.48	GO:0007143	female meiotic nuclear division
0.48	GO:0060561	apoptotic process involved in morphogenesis

0.75	GO:0019888	protein phosphatase regulator activity
0.49	GO:1990405	protein antigen binding
0.45	GO:0004722	protein serine/threonine phosphatase activity
0.43	GO:0046982	protein heterodimerization activity
0.36	GO:0003676	nucleic acid binding
0.35	GO:0046872	metal ion binding

0.47	GO:0000775	chromosome, centromeric region
0.47	GO:0000159	protein phosphatase type 2A complex
0.46	GO:0016328	lateral plasma membrane
0.45	GO:0098857	membrane microdomain
0.45	GO:0030425	dendrite
0.44	GO:0070062	extracellular exosome
0.43	GO:0005829	cytosol
0.36	GO:0015630	microtubule cytoskeleton
0.35	GO:0005634	nucleus
0.35	GO:0005739	mitochondrion

sp|P30154|2AAB_HUMAN
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Search

PPP2R1B

0.87	LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

0.72	GO:0043666	regulation of phosphoprotein phosphatase activity
0.63	GO:0006461	protein complex assembly
0.62	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
0.54	GO:0051232	meiotic spindle elongation
0.53	GO:1903538	regulation of meiotic cell cycle process involved in oocyte maturation
0.53	GO:0060561	apoptotic process involved in morphogenesis
0.52	GO:0051306	mitotic sister chromatid separation
0.52	GO:0051754	meiotic sister chromatid cohesion, centromeric
0.51	GO:0070262	peptidyl-serine dephosphorylation
0.51	GO:0007143	female meiotic nuclear division

0.73	GO:0019888	protein phosphatase regulator activity
0.51	GO:1990405	protein antigen binding
0.47	GO:0004722	protein serine/threonine phosphatase activity
0.45	GO:0046982	protein heterodimerization activity
0.36	GO:0003676	nucleic acid binding
0.36	GO:0046872	metal ion binding

0.50	GO:0098857	membrane microdomain
0.49	GO:0000775	chromosome, centromeric region
0.49	GO:0000159	protein phosphatase type 2A complex
0.48	GO:0016328	lateral plasma membrane
0.47	GO:0070062	extracellular exosome
0.47	GO:0030425	dendrite
0.44	GO:0005829	cytosol
0.37	GO:0015630	microtubule cytoskeleton
0.35	GO:0005634	nucleus
0.35	GO:0005739	mitochondrion

sp|P30203|CD6_HUMAN
T-cell differentiation antigen CD6
Search

CD6

0.97	T-cell differentiation antigen CD6

0.72	GO:0006898	receptor-mediated endocytosis
0.68	GO:0002438	acute inflammatory response to antigenic stimulus
0.67	GO:0001771	immunological synapse formation
0.66	GO:1900017	positive regulation of cytokine production involved in inflammatory response
0.64	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
0.64	GO:0031663	lipopolysaccharide-mediated signaling pathway
0.63	GO:0042102	positive regulation of T cell proliferation
0.39	GO:0001934	positive regulation of protein phosphorylation
0.39	GO:0002250	adaptive immune response
0.38	GO:0045087	innate immune response

0.81	GO:0005044	scavenger receptor activity
0.68	GO:0070891	lipoteichoic acid binding
0.62	GO:0001530	lipopolysaccharide binding
0.56	GO:0042802	identical protein binding
0.39	GO:0019901	protein kinase binding
0.34	GO:0035375	zymogen binding
0.33	GO:0030246	carbohydrate binding

0.65	GO:0042101	T cell receptor complex
0.64	GO:0001772	immunological synapse
0.52	GO:0031226	intrinsic component of plasma membrane
0.42	GO:0089717	spanning component of membrane
0.37	GO:0005576	extracellular region
0.35	GO:0009897	external side of plasma membrane
0.33	GO:0042589	zymogen granule membrane
0.33	GO:0030670	phagocytic vesicle membrane
0.33	GO:0030658	transport vesicle membrane
0.33	GO:0019898	extrinsic component of membrane

sp|P30260|CDC27_HUMAN
Cell division cycle protein 27 homolog
Search

CDC27

0.94	Cell division cycle protein 27

0.60	GO:0051301	cell division
0.56	GO:0007091	metaphase/anaphase transition of mitotic cell cycle
0.55	GO:0070979	protein K11-linked ubiquitination
0.36	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.36	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.35	GO:0031145	anaphase-promoting complex-dependent catabolic process
0.35	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.35	GO:0008283	cell proliferation
0.33	GO:0010469	regulation of receptor activity

0.53	GO:0019903	protein phosphatase binding
0.33	GO:0005179	hormone activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0003677	DNA binding

0.52	GO:0005876	spindle microtubule
0.51	GO:0005680	anaphase-promoting complex
0.50	GO:0005813	centrosome
0.47	GO:0005654	nucleoplasm
0.38	GO:0005737	cytoplasm
0.32	GO:0005576	extracellular region

sp|P30273|FCERG_HUMAN
High affinity immunoglobulin epsilon receptor subunit gamma
Search

FCER1G

0.97	High affinity immunoglobulin epsilon receptor subunit gamma

0.73	GO:0001812	positive regulation of type I hypersensitivity
0.72	GO:0001805	positive regulation of type III hypersensitivity
0.72	GO:0032765	positive regulation of mast cell cytokine production
0.72	GO:0033026	negative regulation of mast cell apoptotic process
0.72	GO:0002894	positive regulation of type II hypersensitivity
0.72	GO:0001796	regulation of type IIa hypersensitivity
0.71	GO:0002554	serotonin secretion by platelet
0.71	GO:0071404	cellular response to low-density lipoprotein particle stimulus
0.70	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
0.69	GO:0043306	positive regulation of mast cell degranulation

0.72	GO:0019767	IgE receptor activity
0.72	GO:0019863	IgE binding
0.71	GO:0019864	IgG binding
0.58	GO:0042803	protein homodimerization activity
0.38	GO:0048038	quinone binding
0.38	GO:0051287	NAD binding
0.37	GO:0016651	oxidoreductase activity, acting on NAD(P)H

0.71	GO:0032997	Fc receptor complex
0.63	GO:0009897	external side of plasma membrane
0.54	GO:0005887	integral component of plasma membrane
0.40	GO:0101003	ficolin-1-rich granule membrane
0.40	GO:0070821	tertiary granule membrane
0.37	GO:0098857	membrane microdomain

0.37

EC:1.6

GO:0016651

sp|P30279|CCND2_HUMAN
G1/S-specific cyclin-D2
Search

CCND2

0.94	G1/S-specific cyclin-D2

0.67	GO:0007049	cell cycle
0.60	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
0.59	GO:0071481	cellular response to X-ray
0.59	GO:2000045	regulation of G1/S transition of mitotic cell cycle
0.59	GO:1901992	positive regulation of mitotic cell cycle phase transition
0.57	GO:0007616	long-term memory
0.57	GO:1902808	positive regulation of cell cycle G1/S phase transition
0.56	GO:0008284	positive regulation of cell proliferation
0.56	GO:0008344	adult locomotory behavior
0.53	GO:0043066	negative regulation of apoptotic process

0.56	GO:0019901	protein kinase binding
0.44	GO:0070064	proline-rich region binding
0.43	GO:0042826	histone deacetylase binding
0.43	GO:0003714	transcription corepressor activity
0.42	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.40	GO:0008134	transcription factor binding
0.38	GO:0004672	protein kinase activity
0.35	GO:0032403	protein complex binding
0.33	GO:0060089	molecular transducer activity
0.32	GO:0003677	DNA binding

0.61	GO:0005634	nucleus
0.60	GO:0097129	cyclin D2-CDK4 complex
0.51	GO:0000785	chromatin
0.50	GO:0070013	intracellular organelle lumen
0.49	GO:0005829	cytosol
0.48	GO:0012505	endomembrane system
0.45	GO:0031967	organelle envelope
0.45	GO:0031090	organelle membrane
0.43	GO:0017053	transcriptional repressor complex
0.42	GO:0005923	bicellular tight junction

0.42

GO:0016538

sp|P30281|CCND3_HUMAN
G1/S-specific cyclin-D3
Search

CCND3

0.87	Cyclin D3 (Predicted)

0.67	GO:0007049	cell cycle
0.60	GO:0042098	T cell proliferation
0.59	GO:0046626	regulation of insulin receptor signaling pathway
0.59	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
0.55	GO:0042127	regulation of cell proliferation
0.55	GO:0000122	negative regulation of transcription by RNA polymerase II
0.46	GO:0007165	signal transduction
0.41	GO:1901992	positive regulation of mitotic cell cycle phase transition
0.41	GO:2000045	regulation of G1/S transition of mitotic cell cycle
0.40	GO:0071481	cellular response to X-ray

0.58	GO:0004693	cyclin-dependent protein serine/threonine kinase activity
0.57	GO:0019901	protein kinase binding
0.37	GO:0070064	proline-rich region binding
0.36	GO:0042826	histone deacetylase binding
0.36	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.36	GO:0003714	transcription corepressor activity
0.35	GO:0008134	transcription factor binding

0.61	GO:0005634	nucleus
0.58	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
0.40	GO:0005737	cytoplasm
0.38	GO:0070013	intracellular organelle lumen
0.37	GO:0000785	chromatin
0.36	GO:0012505	endomembrane system
0.36	GO:0017053	transcriptional repressor complex
0.36	GO:0005923	bicellular tight junction
0.35	GO:0031967	organelle envelope
0.35	GO:0031090	organelle membrane

0.58

EC:2.7.11.22

GO:0004693

sp|P30291|WEE1_HUMAN
Wee1-like protein kinase
Search

WEE1

0.92	WEE1 G2 checkpoint kinase

0.72	GO:0018108	peptidyl-tyrosine phosphorylation
0.70	GO:0000278	mitotic cell cycle
0.55	GO:0030010	establishment of cell polarity
0.54	GO:0048812	neuron projection morphogenesis
0.52	GO:0000226	microtubule cytoskeleton organization
0.42	GO:0009416	response to light stimulus
0.38	GO:0051301	cell division
0.37	GO:0051321	meiotic cell cycle
0.37	GO:0051726	regulation of cell cycle
0.36	GO:0044839	cell cycle G2/M phase transition

0.76	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.61	GO:0000287	magnesium ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0004674	protein serine/threonine kinase activity
0.36	GO:0005515	protein binding
0.32	GO:0003676	nucleic acid binding

0.58	GO:0005634	nucleus
0.48	GO:0031974	membrane-enclosed lumen
0.44	GO:0043232	intracellular non-membrane-bounded organelle
0.44	GO:0044446	intracellular organelle part
0.39	GO:0005737	cytoplasm

0.76

GO:0004715

sp|P30301|MIP_HUMAN
Lens fiber major intrinsic protein
Search

MIP

0.93	Major intrinsic protein of eye lens fiber

0.64	GO:0006833	water transport
0.61	GO:1990349	gap junction-mediated intercellular transport
0.60	GO:0002088	lens development in camera-type eye
0.56	GO:0051289	protein homotetramerization
0.55	GO:0055085	transmembrane transport
0.52	GO:0045785	positive regulation of cell adhesion
0.51	GO:0007601	visual perception
0.44	GO:0071288	cellular response to mercury ion
0.43	GO:0071280	cellular response to copper ion
0.43	GO:0015793	glycerol transport

0.69	GO:0022803	passive transmembrane transporter activity
0.64	GO:0005372	water transmembrane transporter activity
0.56	GO:0005212	structural constituent of eye lens
0.43	GO:0015168	glycerol transmembrane transporter activity
0.41	GO:0005516	calmodulin binding
0.35	GO:0015204	urea transmembrane transporter activity
0.34	GO:0046983	protein dimerization activity

0.52	GO:0016324	apical plasma membrane
0.49	GO:0012505	endomembrane system
0.44	GO:0005887	integral component of plasma membrane
0.44	GO:0043227	membrane-bounded organelle
0.43	GO:0044444	cytoplasmic part
0.42	GO:0005921	gap junction
0.42	GO:0043229	intracellular organelle
0.41	GO:0043230	extracellular organelle
0.39	GO:0016323	basolateral plasma membrane
0.39	GO:0005615	extracellular space

sp|P30304|MPIP1_HUMAN
M-phase inducer phosphatase 1
Search

CDC25A

0.97	Cell division cycle 25 homolog A

0.84	GO:1902751	positive regulation of cell cycle G2/M phase transition
0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.64	GO:0034644	cellular response to UV
0.48	GO:0051301	cell division
0.46	GO:0009794	regulation of mitotic cell cycle, embryonic
0.46	GO:0045931	positive regulation of mitotic cell cycle
0.44	GO:0010389	regulation of G2/M transition of mitotic cell cycle
0.39	GO:0032467	positive regulation of cytokinesis
0.38	GO:0007144	female meiosis I
0.38	GO:0001556	oocyte maturation

0.75	GO:0004725	protein tyrosine phosphatase activity
0.62	GO:0019901	protein kinase binding
0.60	GO:0051087	chaperone binding

0.50	GO:0005634	nucleus
0.42	GO:0005737	cytoplasm
0.38	GO:0000922	spindle pole
0.38	GO:0005813	centrosome

0.75

GO:0004725

sp|P30305|MPIP2_HUMAN
M-phase inducer phosphatase 2
Search

CDC25B

0.89	Cell division cycle 25 homolog B

0.84	GO:1902751	positive regulation of cell cycle G2/M phase transition
0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.66	GO:0007144	female meiosis I
0.65	GO:0001556	oocyte maturation
0.63	GO:0032467	positive regulation of cytokinesis
0.63	GO:0045931	positive regulation of mitotic cell cycle
0.59	GO:0045860	positive regulation of protein kinase activity
0.50	GO:0006468	protein phosphorylation
0.49	GO:0034644	cellular response to UV
0.47	GO:0051301	cell division

0.75	GO:0004725	protein tyrosine phosphatase activity
0.63	GO:0019901	protein kinase binding
0.46	GO:0051087	chaperone binding

0.60	GO:0000922	spindle pole
0.59	GO:0005813	centrosome
0.51	GO:0005634	nucleus
0.43	GO:0005737	cytoplasm

0.75

GO:0004725

sp|P30307|MPIP3_HUMAN
M-phase inducer phosphatase 3
Search

CDC25C

0.83	M-phase inducer phosphatase 1-B

0.84	GO:1902751	positive regulation of cell cycle G2/M phase transition
0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.56	GO:0000086	G2/M transition of mitotic cell cycle
0.48	GO:0045931	positive regulation of mitotic cell cycle
0.48	GO:0007144	female meiosis I
0.47	GO:0001556	oocyte maturation
0.46	GO:0032467	positive regulation of cytokinesis
0.45	GO:0045859	regulation of protein kinase activity
0.44	GO:0033674	positive regulation of kinase activity
0.44	GO:0001934	positive regulation of protein phosphorylation

0.75	GO:0004725	protein tyrosine phosphatase activity
0.57	GO:0050699	WW domain binding
0.57	GO:0019901	protein kinase binding
0.34	GO:0003735	structural constituent of ribosome
0.33	GO:0051087	chaperone binding

0.54	GO:0016607	nuclear speck
0.45	GO:0000922	spindle pole
0.44	GO:0005813	centrosome
0.40	GO:0005737	cytoplasm
0.33	GO:0030529	intracellular ribonucleoprotein complex

0.75

GO:0004725

sp|P30405|PPIF_HUMAN
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Search

PPIF

0.49	Peptidyl-prolyl cis-trans isomerase

0.72	GO:0000413	protein peptidyl-prolyl isomerization
0.68	GO:0006457	protein folding
0.57	GO:0010849	regulation of proton-transporting ATPase activity, rotational mechanism
0.56	GO:2000276	negative regulation of oxidative phosphorylation uncoupler activity
0.56	GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
0.56	GO:0090201	negative regulation of release of cytochrome c from mitochondria
0.56	GO:1902686	mitochondrial outer membrane permeabilization involved in programmed cell death
0.55	GO:0090324	negative regulation of oxidative phosphorylation
0.55	GO:0070301	cellular response to hydrogen peroxide
0.54	GO:0071243	cellular response to arsenic-containing substance

0.72	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.41	GO:0016018	cyclosporin A binding
0.35	GO:0005515	protein binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003723	RNA binding
0.32	GO:0016301	kinase activity

0.57	GO:0005757	mitochondrial permeability transition pore complex
0.42	GO:0005759	mitochondrial matrix
0.38	GO:0005753	mitochondrial proton-transporting ATP synthase complex
0.34	GO:0009533	chloroplast stromal thylakoid
0.33	GO:0031977	thylakoid lumen
0.33	GO:0005750	mitochondrial respiratory chain complex III
0.33	GO:0009535	chloroplast thylakoid membrane

0.72

GO:0003755

sp|P30408|T4S1_HUMAN
Transmembrane 4 L6 family member 1
Search

TM4SF1

0.94	Transmembrane 4 L six family member 1

0.33

GO:0005515

protein binding

0.47

GO:0005887

integral component of plasma membrane

sp|P30411|BKRB2_HUMAN
B2 bradykinin receptor
Search

BDKRB2

0.97	Bradykinin receptor, beta 2

0.82	GO:0006939	smooth muscle contraction
0.82	GO:0042310	vasoconstriction
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.64	GO:1902238	regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
0.62	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
0.62	GO:0006950	response to stress
0.60	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
0.60	GO:0033137	negative regulation of peptidyl-serine phosphorylation
0.59	GO:0042311	vasodilation
0.58	GO:0050482	arachidonic acid secretion

0.86	GO:0004947	bradykinin receptor activity
0.64	GO:0031702	type 1 angiotensin receptor binding
0.59	GO:0002020	protease binding
0.54	GO:0046982	protein heterodimerization activity
0.36	GO:0031698	beta-2 adrenergic receptor binding
0.36	GO:0004435	phosphatidylinositol phospholipase C activity
0.35	GO:0042277	peptide binding
0.33	GO:1990239	steroid hormone binding
0.33	GO:0030284	estrogen receptor activity
0.33	GO:0015057	thrombin-activated receptor activity

0.54	GO:0005768	endosome
0.44	GO:0005886	plasma membrane
0.33	GO:0045095	keratin filament
0.32	GO:0005802	trans-Golgi network
0.32	GO:0048471	perinuclear region of cytoplasm
0.32	GO:0030659	cytoplasmic vesicle membrane
0.32	GO:0005635	nuclear envelope
0.32	GO:0005783	endoplasmic reticulum
0.30	GO:0016021	integral component of membrane

0.36	EC:3.1.4.11	GO:0004435
0.36	KEGG:R03435	GO:0004435

sp|P30414|NKTR_HUMAN
NK-tumor recognition protein
Search

NKTR

0.83	NK-tumor recognition protein isoform X1

0.72	GO:0000413	protein peptidyl-prolyl isomerization
0.65	GO:0006457	protein folding
0.32	GO:2001141	regulation of RNA biosynthetic process

0.72	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.34	GO:0016018	cyclosporin A binding
0.33	GO:0003713	transcription coactivator activity
0.31	GO:0003676	nucleic acid binding

0.38	GO:0005654	nucleoplasm
0.37	GO:0005829	cytosol
0.36	GO:0005739	mitochondrion
0.35	GO:0005886	plasma membrane

0.72

GO:0003755

sp|P30419|NMT1_HUMAN
Glycylpeptide N-tetradecanoyltransferase 1
Search

NMT1

0.72	Glycylpeptide N-tetradecanoyltransferase

0.85	GO:0006499	N-terminal protein myristoylation
0.59	GO:0018201	peptidyl-glycine modification
0.51	GO:0001701	in utero embryonic development
0.48	GO:0042180	cellular ketone metabolic process
0.36	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
0.35	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
0.35	GO:0022400	regulation of rhodopsin mediated signaling pathway
0.35	GO:1903749	positive regulation of establishment of protein localization to mitochondrion
0.34	GO:0071901	negative regulation of protein serine/threonine kinase activity
0.34	GO:1905477	positive regulation of protein localization to membrane

0.85	GO:0004379	glycylpeptide N-tetradecanoyltransferase activity
0.35	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
0.34	GO:0017069	snRNA binding
0.34	GO:0000062	fatty-acyl-CoA binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.51	GO:0019898	extrinsic component of membrane
0.48	GO:0005829	cytosol
0.42	GO:0005886	plasma membrane
0.36	GO:0005794	Golgi apparatus
0.33	GO:0005739	mitochondrion
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.85

EC:2.3.1.97

GO:0004379

sp|P30511|HLAF_HUMAN
HLA class I histocompatibility antigen, alpha chain F
Search

0.40	Mamu class I histocompatibility antigen, alpha chain F

0.56	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
0.51	GO:0006955	immune response
0.35	GO:0002478	antigen processing and presentation of exogenous peptide antigen
0.34	GO:0019221	cytokine-mediated signaling pathway
0.34	GO:0006952	defense response
0.34	GO:0050776	regulation of immune response

0.40	GO:0046978	TAP1 binding
0.40	GO:0046979	TAP2 binding
0.40	GO:0042605	peptide antigen binding
0.37	GO:0005102	receptor binding

0.55	GO:0042612	MHC class I protein complex
0.37	GO:0009986	cell surface
0.37	GO:0005783	endoplasmic reticulum
0.35	GO:0030670	phagocytic vesicle membrane
0.35	GO:0055038	recycling endosome membrane
0.35	GO:0031901	early endosome membrane
0.34	GO:0012507	ER to Golgi transport vesicle membrane
0.34	GO:0098552	side of membrane
0.34	GO:0000139	Golgi membrane
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network

sp|P30518|V2R_HUMAN
Vasopressin V2 receptor
Search

AVPR2

0.97	Vasopressin V2 receptor

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.57	GO:0032609	interferon-gamma production
0.55	GO:0007249	I-kappaB kinase/NF-kappaB signaling
0.52	GO:0034097	response to cytokine
0.50	GO:0001992	regulation of systemic arterial blood pressure by vasopressin
0.49	GO:0045907	positive regulation of vasoconstriction
0.46	GO:1901652	response to peptide
0.45	GO:0032870	cellular response to hormone stimulus
0.43	GO:0035814	negative regulation of renal sodium excretion
0.42	GO:0035811	negative regulation of urine volume

0.85	GO:0005000	vasopressin receptor activity
0.46	GO:0042277	peptide binding
0.35	GO:0042562	hormone binding
0.34	GO:0005515	protein binding

0.48	GO:0005886	plasma membrane
0.37	GO:0005622	intracellular
0.35	GO:0012506	vesicle membrane
0.34	GO:0098805	whole membrane
0.34	GO:0098588	bounding membrane of organelle
0.34	GO:0012505	endomembrane system
0.30	GO:0016021	integral component of membrane

sp|P30519|HMOX2_HUMAN
Heme oxygenase 2
Search

HMOX2

0.58	Heme oxygenase

0.82	GO:0006788	heme oxidation
0.52	GO:0042167	heme catabolic process
0.47	GO:0055072	iron ion homeostasis
0.46	GO:0006979	response to oxidative stress
0.43	GO:0001666	response to hypoxia
0.42	GO:0002246	wound healing involved in inflammatory response
0.42	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron
0.42	GO:0072719	cellular response to cisplatin
0.42	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
0.42	GO:0071243	cellular response to arsenic-containing substance

0.82	GO:0004392	heme oxygenase (decyclizing) activity
0.47	GO:0046872	metal ion binding
0.43	GO:0020037	heme binding
0.39	GO:0042803	protein homodimerization activity
0.36	GO:0004630	phospholipase D activity
0.34	GO:0019899	enzyme binding
0.33	GO:0004871	signal transducer activity

0.41	GO:0005783	endoplasmic reticulum
0.40	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0005634	nucleus
0.36	GO:0035579	specific granule membrane
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0005901	caveola
0.35	GO:0031984	organelle subcompartment
0.34	GO:0005829	cytosol
0.34	GO:0070013	intracellular organelle lumen
0.33	GO:0043232	intracellular non-membrane-bounded organelle

0.82

EC:1.14.99.3

GO:0004392

sp|P30520|PURA2_HUMAN
Adenylosuccinate synthetase isozyme 2
Search

ADSS

0.45	Adenylosuccinate synthetase

0.72	GO:0044208	'de novo' AMP biosynthetic process
0.45	GO:0046040	IMP metabolic process
0.43	GO:0071257	cellular response to electrical stimulus
0.41	GO:0006531	aspartate metabolic process
0.40	GO:0014074	response to purine-containing compound
0.40	GO:0060359	response to ammonium ion
0.36	GO:0014850	response to muscle activity
0.35	GO:0035690	cellular response to drug
0.35	GO:0042594	response to starvation
0.35	GO:0002376	immune system process

0.78	GO:0004019	adenylosuccinate synthase activity
0.65	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.58	GO:0000287	magnesium ion binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0042301	phosphate ion binding
0.35	GO:0051015	actin filament binding
0.35	GO:0042803	protein homodimerization activity
0.34	GO:0003924	GTPase activity

0.47	GO:0005829	cytosol
0.42	GO:0005886	plasma membrane
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.78	EC:6.3.4.4	GO:0004019
0.78	KEGG:R01135	GO:0004019

sp|P30530|UFO_HUMAN
Tyrosine-protein kinase receptor UFO
Search

AXL

0.97	AXL receptor tyrosine kinase

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.73	GO:0048549	positive regulation of pinocytosis
0.73	GO:0097350	neutrophil clearance
0.72	GO:2000669	negative regulation of dendritic cell apoptotic process
0.72	GO:0032825	positive regulation of natural killer cell differentiation
0.71	GO:0060068	vagina development
0.71	GO:0001779	natural killer cell differentiation
0.71	GO:0035457	cellular response to interferon-alpha
0.70	GO:0032689	negative regulation of interferon-gamma production
0.70	GO:0097028	dendritic cell differentiation

0.77	GO:0004713	protein tyrosine kinase activity
0.69	GO:0001786	phosphatidylserine binding
0.60	GO:0046982	protein heterodimerization activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0032036	myosin heavy chain binding
0.48	GO:0043548	phosphatidylinositol 3-kinase binding
0.47	GO:0019838	growth factor binding

0.64	GO:0044228	host cell surface
0.61	GO:0009986	cell surface
0.59	GO:0005615	extracellular space
0.46	GO:1903561	extracellular vesicle
0.40	GO:0005622	intracellular
0.30	GO:0016020	membrane

0.77

GO:0004713

sp|P30531|SC6A1_HUMAN
Sodium- and chloride-dependent GABA transporter 1
Search

SLC6A1

0.58	Sodium- and chloride-dependent GABA transporter 1

0.85	GO:0015812	gamma-aminobutyric acid transport
0.67	GO:0032229	negative regulation of synaptic transmission, GABAergic
0.67	GO:0014054	positive regulation of gamma-aminobutyric acid secretion
0.65	GO:0010288	response to lead ion
0.63	GO:0042220	response to cocaine
0.63	GO:0009744	response to sucrose
0.62	GO:0032355	response to estradiol
0.62	GO:0043090	amino acid import
0.61	GO:0051592	response to calcium ion
0.61	GO:0007612	learning

0.86	GO:0005332	gamma-aminobutyric acid:sodium symporter activity
0.44	GO:0046872	metal ion binding
0.41	GO:0005515	protein binding

0.67	GO:0005887	integral component of plasma membrane
0.66	GO:0030424	axon
0.56	GO:0009986	cell surface

sp|P30532|ACHA5_HUMAN
Neuronal acetylcholine receptor subunit alpha-5
Search

CHRNA5

0.92	Neuronal acetylcholine receptor subunit alpha-5

0.77	GO:0060079	excitatory postsynaptic potential
0.60	GO:0034220	ion transmembrane transport
0.52	GO:0035094	response to nicotine
0.48	GO:0007271	synaptic transmission, cholinergic
0.48	GO:0007274	neuromuscular synaptic transmission
0.45	GO:0030534	adult behavior
0.38	GO:0006812	cation transport

0.80	GO:0022848	acetylcholine-gated cation-selective channel activity
0.69	GO:0099600	transmembrane receptor activity
0.49	GO:0042166	acetylcholine binding
0.36	GO:0005515	protein binding

0.77	GO:0045211	postsynaptic membrane
0.72	GO:0030054	cell junction
0.51	GO:0005892	acetylcholine-gated channel complex
0.36	GO:0043025	neuronal cell body
0.36	GO:0030425	dendrite

sp|P30533|AMRP_HUMAN
Alpha-2-macroglobulin receptor-associated protein
Search

LRPAP1

0.93	Low density lipoprotein receptor-associated protein 1

0.86	GO:1900116	extracellular negative regulation of signal transduction
0.59	GO:1900222	negative regulation of amyloid-beta clearance
0.59	GO:0010916	negative regulation of very-low-density lipoprotein particle clearance
0.58	GO:0002091	negative regulation of receptor internalization
0.57	GO:0045056	transcytosis
0.55	GO:0032091	negative regulation of protein binding
0.52	GO:0060548	negative regulation of cell death
0.36	GO:1900223	positive regulation of amyloid-beta clearance

0.86	GO:0048019	receptor antagonist activity
0.86	GO:0050750	low-density lipoprotein particle receptor binding
0.83	GO:0008201	heparin binding
0.58	GO:0070326	very-low-density lipoprotein particle receptor binding
0.41	GO:0035473	lipase binding
0.36	GO:0001540	amyloid-beta binding

0.70	GO:0005783	endoplasmic reticulum
0.66	GO:0005576	extracellular region
0.54	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.53	GO:0005801	cis-Golgi network
0.51	GO:0005768	endosome
0.49	GO:0005794	Golgi apparatus
0.47	GO:0043233	organelle lumen
0.42	GO:0044446	intracellular organelle part
0.42	GO:0005886	plasma membrane
0.37	GO:0009986	cell surface

sp|P30536|TSPO_HUMAN
Translocator protein
Search

TSPO

0.90	Peripheral benzodiazepine receptor

0.60	GO:0072656	maintenance of protein location in mitochondrion
0.59	GO:1903147	negative regulation of autophagy of mitochondrion
0.58	GO:1903578	regulation of ATP metabolic process
0.57	GO:1900543	negative regulation of purine nucleotide metabolic process
0.56	GO:0031397	negative regulation of protein ubiquitination
0.56	GO:2000379	positive regulation of reactive oxygen species metabolic process
0.53	GO:0072655	establishment of protein localization to mitochondrion
0.44	GO:0060319	primitive erythrocyte differentiation
0.41	GO:0007568	aging
0.41	GO:0043065	positive regulation of apoptotic process

0.56	GO:0044325	ion channel binding
0.42	GO:0008503	benzodiazepine receptor activity
0.40	GO:0005497	androgen binding
0.38	GO:0015485	cholesterol binding
0.36	GO:0017127	cholesterol transporter activity

0.46	GO:0005739	mitochondrion
0.41	GO:0031968	organelle outer membrane
0.37	GO:0070062	extracellular exosome
0.35	GO:0005783	endoplasmic reticulum
0.30	GO:0016021	integral component of membrane

sp|P30542|AA1R_HUMAN
Adenosine receptor A1
Search

ADORA1

0.97	Adenosine receptor A1

0.85	GO:0001973	adenosine receptor signaling pathway
0.61	GO:0070256	negative regulation of mucus secretion
0.61	GO:1900453	negative regulation of long term synaptic depression
0.60	GO:0003093	regulation of glomerular filtration
0.59	GO:0051930	regulation of sensory perception of pain
0.58	GO:0002686	negative regulation of leukocyte migration
0.56	GO:0050728	negative regulation of inflammatory response
0.54	GO:0060079	excitatory postsynaptic potential
0.42	GO:0008285	negative regulation of cell proliferation
0.41	GO:0032088	negative regulation of NF-kappaB transcription factor activity

0.85	GO:0001609	G-protein coupled adenosine receptor activity
0.40	GO:0032795	heterotrimeric G-protein binding
0.38	GO:0031683	G-protein beta/gamma-subunit complex binding
0.38	GO:0001664	G-protein coupled receptor binding
0.38	GO:0004629	phospholipase C activity
0.37	GO:0031072	heat shock protein binding
0.37	GO:0046982	protein heterodimerization activity
0.36	GO:0001883	purine nucleoside binding

0.57	GO:0043197	dendritic spine
0.55	GO:0005886	plasma membrane
0.39	GO:0043195	terminal bouton
0.38	GO:0044304	main axon
0.38	GO:0014069	postsynaptic density
0.38	GO:0048786	presynaptic active zone
0.38	GO:0043025	neuronal cell body
0.38	GO:0031252	cell leading edge
0.36	GO:0005783	endoplasmic reticulum
0.34	GO:0042629	mast cell granule

sp|P30550|GRPR_HUMAN
Gastrin-releasing peptide receptor
Search

GRPR

0.97	Gastrin-releasing peptide receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.58	GO:0036343	psychomotor behavior
0.56	GO:0035176	social behavior
0.51	GO:0042127	regulation of cell proliferation
0.48	GO:0043207	response to external biotic stimulus
0.35	GO:0007611	learning or memory
0.35	GO:0008283	cell proliferation

0.79	GO:0008528	G-protein coupled peptide receptor activity
0.35	GO:0042923	neuropeptide binding
0.33	GO:0005515	protein binding

0.47	GO:0005887	integral component of plasma membrane
0.39	GO:0005829	cytosol

sp|P30556|AGTR1_HUMAN
Type-1 angiotensin II receptor
Search

AGTR1

0.97	Type-1 angiotensin II receptor

0.84	GO:0038166	angiotensin-activated signaling pathway
0.82	GO:0019229	regulation of vasoconstriction
0.42	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
0.41	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.41	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin
0.41	GO:0042756	drinking behavior
0.40	GO:0003071	renal system process involved in regulation of systemic arterial blood pressure
0.40	GO:0071549	cellular response to dexamethasone stimulus
0.40	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
0.40	GO:0045777	positive regulation of blood pressure

0.85	GO:0004945	angiotensin type II receptor activity
0.43	GO:0001596	angiotensin type I receptor activity
0.40	GO:0031711	bradykinin receptor binding
0.40	GO:0017046	peptide hormone binding
0.40	GO:0043621	protein self-association
0.38	GO:0031748	D1 dopamine receptor binding
0.37	GO:0001965	G-protein alpha-subunit binding
0.37	GO:0046982	protein heterodimerization activity
0.36	GO:0019901	protein kinase binding

0.40	GO:0031983	vesicle lumen
0.39	GO:0016323	basolateral plasma membrane
0.38	GO:0012506	vesicle membrane
0.37	GO:0055037	recycling endosome
0.36	GO:0030425	dendrite
0.36	GO:0031968	organelle outer membrane
0.35	GO:0005794	Golgi apparatus
0.34	GO:0005887	integral component of plasma membrane

sp|P30559|OXYR_HUMAN
Oxytocin receptor
Search

OXTR

0.96	Oxytocin receptor

0.68	GO:0007186	G-protein coupled receptor signaling pathway
0.56	GO:0045777	positive regulation of blood pressure
0.49	GO:0001992	regulation of systemic arterial blood pressure by vasopressin
0.48	GO:0045907	positive regulation of vasoconstriction
0.47	GO:0042711	maternal behavior
0.46	GO:1901652	response to peptide
0.46	GO:0035176	social behavior
0.46	GO:0007595	lactation
0.45	GO:0007565	female pregnancy
0.44	GO:0009725	response to hormone

0.85	GO:0004990	oxytocin receptor activity
0.83	GO:0005000	vasopressin receptor activity
0.46	GO:0042277	peptide binding
0.39	GO:0042562	hormone binding
0.33	GO:0004984	olfactory receptor activity
0.33	GO:0005515	protein binding

0.49	GO:0005886	plasma membrane
0.39	GO:0005902	microvillus
0.39	GO:0005913	cell-cell adherens junction
0.39	GO:0045177	apical part of cell
0.33	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

sp|P30566|PUR8_HUMAN
Adenylosuccinate lyase
Search

ADSL

0.48	Adenylosuccinate lyase

0.75	GO:0044208	'de novo' AMP biosynthetic process
0.69	GO:0006189	'de novo' IMP biosynthetic process
0.52	GO:0051262	protein tetramerization
0.40	GO:0014850	response to muscle activity
0.39	GO:0001666	response to hypoxia
0.39	GO:0007584	response to nutrient
0.38	GO:0042594	response to starvation
0.36	GO:0009060	aerobic respiration

0.78	GO:0004018	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
0.78	GO:0070626	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity

0.48	GO:0005829	cytosol
0.43	GO:0005739	mitochondrion

0.78	EC:4.3.2.2	GO:0004018
0.78	KEGG:R01083	GO:0004018

sp|P30613|KPYR_HUMAN
Pyruvate kinase PKLR
Search

PKLR

0.47	Pyruvate kinase PKLR

0.71	GO:0006757	ATP generation from ADP
0.69	GO:0006090	pyruvate metabolic process
0.68	GO:0016052	carbohydrate catabolic process
0.67	GO:0019362	pyridine nucleotide metabolic process
0.47	GO:0032868	response to insulin
0.47	GO:0071375	cellular response to peptide hormone stimulus
0.42	GO:0012501	programmed cell death
0.39	GO:0071872	cellular response to epinephrine stimulus
0.39	GO:0010226	response to lithium ion
0.39	GO:0001666	response to hypoxia

0.78	GO:0004743	pyruvate kinase activity
0.77	GO:0030955	potassium ion binding
0.64	GO:0000287	magnesium ion binding
0.60	GO:0016301	kinase activity
0.43	GO:0045296	cadherin binding
0.36	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0043168	anion binding
0.35	GO:0008144	drug binding
0.35	GO:0070324	thyroid hormone binding
0.34	GO:0005248	voltage-gated sodium channel activity

0.43	GO:0043209	myelin sheath
0.42	GO:0005829	cytosol
0.42	GO:0005929	cilium
0.38	GO:0005739	mitochondrion
0.38	GO:0005634	nucleus
0.36	GO:0070062	extracellular exosome
0.35	GO:1902912	pyruvate kinase complex
0.34	GO:0031012	extracellular matrix
0.33	GO:0005887	integral component of plasma membrane

0.78

EC:2.7.1.40

GO:0004743

sp|P30622|CLIP1_HUMAN
CAP-Gly domain-containing linker protein 1
Search

CLIP1

0.89	CAP-Gly domain-containing linker protein 1

0.88	GO:0044861	protein transport into plasma membrane raft
0.85	GO:0031116	positive regulation of microtubule polymerization
0.82	GO:0001578	microtubule bundle formation
0.40	GO:0007062	sister chromatid cohesion
0.40	GO:0000278	mitotic cell cycle
0.33	GO:1900006	positive regulation of dendrite development

0.84	GO:0051010	microtubule plus-end binding
0.62	GO:0008270	zinc ion binding
0.42	GO:0042802	identical protein binding
0.39	GO:0046983	protein dimerization activity

0.86	GO:0044352	pinosome
0.85	GO:0035371	microtubule plus-end
0.82	GO:0005881	cytoplasmic microtubule
0.77	GO:0005813	centrosome
0.75	GO:0005635	nuclear envelope
0.47	GO:0001726	ruffle
0.45	GO:0030659	cytoplasmic vesicle membrane
0.41	GO:0005882	intermediate filament
0.40	GO:0000776	kinetochore
0.38	GO:0005829	cytosol

sp|P30626|SORCN_HUMAN
Sorcin
Search

SRI

0.96	Sorcin isoform C

0.56	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction
0.56	GO:0055118	negative regulation of cardiac muscle contraction
0.55	GO:1901077	regulation of relaxation of muscle
0.55	GO:0010459	negative regulation of heart rate
0.55	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
0.55	GO:1901841	regulation of high voltage-gated calcium channel activity
0.55	GO:0042994	cytoplasmic sequestering of transcription factor
0.54	GO:0086004	regulation of cardiac muscle cell contraction
0.54	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
0.54	GO:2000678	negative regulation of transcription regulatory region DNA binding

0.70	GO:0005509	calcium ion binding
0.53	GO:0070491	repressing transcription factor binding
0.53	GO:0002020	protease binding
0.51	GO:0046982	protein heterodimerization activity
0.48	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.42	GO:0042802	identical protein binding
0.35	GO:0005246	calcium channel regulator activity
0.35	GO:0044325	ion channel binding
0.34	GO:0005102	receptor binding

0.56	GO:0042584	chromaffin granule membrane
0.52	GO:0030018	Z disc
0.51	GO:0070062	extracellular exosome
0.48	GO:0005829	cytosol
0.48	GO:0005789	endoplasmic reticulum membrane
0.47	GO:0005654	nucleoplasm
0.42	GO:0005886	plasma membrane
0.40	GO:0044326	dendritic spine neck
0.39	GO:0016529	sarcoplasmic reticulum
0.39	GO:0005790	smooth endoplasmic reticulum

sp|P30679|GNA15_HUMAN
Guanine nucleotide-binding protein subunit alpha-15
Search

GNA15

0.87	Guanine nucleotide-binding protein G(q) subunit alpha

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.52	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.48	GO:0045634	regulation of melanocyte differentiation
0.48	GO:0001508	action potential
0.46	GO:0007603	phototransduction, visible light
0.46	GO:0071467	cellular response to pH
0.46	GO:0095500	acetylcholine receptor signaling pathway
0.46	GO:0048066	developmental pigmentation
0.46	GO:0009649	entrainment of circadian clock
0.45	GO:0001501	skeletal system development

0.81	GO:0031683	G-protein beta/gamma-subunit complex binding
0.78	GO:0001664	G-protein coupled receptor binding
0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.64	GO:0004871	signal transducer activity
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity
0.36	GO:0046872	metal ion binding

0.50	GO:1905360	GTPase complex
0.50	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.46	GO:0001750	photoreceptor outer segment
0.44	GO:0098797	plasma membrane protein complex
0.36	GO:0005765	lysosomal membrane
0.35	GO:0070062	extracellular exosome
0.33	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.36

EC:3.1.4.39

GO:0047391

sp|P30711|GSTT1_HUMAN
Glutathione S-transferase theta-1
Search

0.84	Glutathione S-transferase theta 1

0.56	GO:0006749	glutathione metabolic process
0.40	GO:0018900	dichloromethane metabolic process
0.39	GO:0033197	response to vitamin E
0.39	GO:0010269	response to selenium ion
0.39	GO:0070887	cellular response to chemical stimulus
0.38	GO:1990823	response to leukemia inhibitory factor
0.38	GO:0009751	response to salicylic acid
0.37	GO:1901685	glutathione derivative metabolic process
0.37	GO:0098754	detoxification
0.36	GO:0006304	DNA modification

0.58	GO:0004364	glutathione transferase activity
0.39	GO:0047651	alkylhalidase activity
0.39	GO:0004602	glutathione peroxidase activity
0.34	GO:0005515	protein binding

0.39	GO:0005737	cytoplasm
0.38	GO:0070062	extracellular exosome
0.36	GO:0005634	nucleus

0.58	EC:2.5.1.18	GO:0004364
0.39	KEGG:R03523	GO:0047651

sp|P30740|ILEU_HUMAN
Leukocyte elastase inhibitor
Search

SERPINB1

0.82	Leukocyte elastase inhibitor A

0.76	GO:0010951	negative regulation of endopeptidase activity
0.40	GO:0042176	regulation of protein catabolic process
0.38	GO:0043312	neutrophil degranulation

0.79

GO:0004867

serine-type endopeptidase inhibitor activity

0.73	GO:0005615	extracellular space
0.44	GO:0031012	extracellular matrix
0.39	GO:1903561	extracellular vesicle
0.38	GO:0034774	secretory granule lumen
0.30	GO:0031224	intrinsic component of membrane

sp|P30793|GCH1_HUMAN
GTP cyclohydrolase 1
Search

GCH1

0.44	GTP cyclohydrolase I

0.75	GO:0046654	tetrahydrofolate biosynthetic process
0.58	GO:0014916	regulation of lung blood pressure
0.56	GO:0042416	dopamine biosynthetic process
0.56	GO:0010460	positive regulation of heart rate
0.56	GO:0051000	positive regulation of nitric-oxide synthase activity
0.56	GO:2000121	regulation of removal of superoxide radicals
0.56	GO:0050884	neuromuscular process controlling posture
0.54	GO:0034341	response to interferon-gamma
0.54	GO:0046146	tetrahydrobiopterin metabolic process
0.54	GO:0034312	diol biosynthetic process

0.79	GO:0003934	GTP cyclohydrolase I activity
0.55	GO:0051019	mitogen-activated protein kinase binding
0.49	GO:0042803	protein homodimerization activity
0.47	GO:0032550	purine ribonucleoside binding
0.47	GO:0019001	guanyl nucleotide binding
0.46	GO:0003924	GTPase activity
0.46	GO:0008270	zinc ion binding
0.42	GO:0030742	GTP-dependent protein binding
0.42	GO:0032555	purine ribonucleotide binding
0.42	GO:0035639	purine ribonucleoside triphosphate binding

0.52	GO:0031965	nuclear membrane
0.49	GO:0005737	cytoplasm
0.48	GO:0097708	intracellular vesicle
0.48	GO:0005654	nucleoplasm
0.43	GO:0043234	protein complex
0.35	GO:0044306	neuron projection terminus

0.79	EC:3.5.4.16	GO:0003934
0.79	KEGG:R00424	GO:0003934

sp|P30825|CTR1_HUMAN
High affinity cationic amino acid transporter 1
Search

SLC7A1

0.65	High affinity cationic amino acid transporter

0.69	GO:0006865	amino acid transport
0.55	GO:0055085	transmembrane transport
0.45	GO:0006812	cation transport
0.35	GO:0002537	nitric oxide production involved in inflammatory response
0.34	GO:0048583	regulation of response to stimulus
0.34	GO:0043030	regulation of macrophage activation
0.34	GO:0042116	macrophage activation
0.34	GO:0006809	nitric oxide biosynthetic process
0.34	GO:0010646	regulation of cell communication
0.34	GO:0023051	regulation of signaling

0.57	GO:0022857	transmembrane transporter activity
0.33	GO:0005515	protein binding

0.34	GO:0005886	plasma membrane
0.33	GO:0030054	cell junction
0.30	GO:0016021	integral component of membrane

sp|P30837|AL1B1_HUMAN
Aldehyde dehydrogenase X, mitochondrial
Search

0.61	Aldehyde dehydrogenase X, mitochondrial

0.53	GO:0055114	oxidation-reduction process
0.47	GO:0006068	ethanol catabolic process
0.43	GO:0006117	acetaldehyde metabolic process
0.41	GO:0045471	response to ethanol
0.40	GO:1901215	negative regulation of neuron death
0.35	GO:0033574	response to testosterone
0.35	GO:0055093	response to hyperoxia
0.35	GO:0032570	response to progesterone
0.35	GO:0035094	response to nicotine
0.34	GO:0071398	cellular response to fatty acid

0.69	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.38	GO:0051287	NAD binding
0.34	GO:0005515	protein binding
0.33	GO:0004222	metalloendopeptidase activity
0.33	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
0.33	GO:0050660	flavin adenine dinucleotide binding
0.33	GO:0004672	protein kinase activity
0.33	GO:0009055	electron transfer activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding

0.47	GO:0005739	mitochondrion
0.47	GO:0031974	membrane-enclosed lumen
0.44	GO:0044428	nuclear part
0.35	GO:0070062	extracellular exosome
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.69

EC:1.2.1

GO:0016620

sp|P30838|AL3A1_HUMAN
Aldehyde dehydrogenase, dimeric NADP-preferring
Search

ALDH3A1

0.43	Aldehyde dehydrogenase, dimeric NADP-preferring

0.66	GO:0006081	cellular aldehyde metabolic process
0.52	GO:0055114	oxidation-reduction process
0.51	GO:0033306	phytol metabolic process
0.48	GO:0007422	peripheral nervous system development
0.47	GO:0008544	epidermis development
0.46	GO:0007417	central nervous system development
0.37	GO:0051591	response to cAMP
0.37	GO:0051384	response to glucocorticoid
0.36	GO:0001666	response to hypoxia
0.36	GO:0007584	response to nutrient

0.76	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
0.56	GO:0004029	aldehyde dehydrogenase (NAD) activity
0.53	GO:0008106	alcohol dehydrogenase (NADP+) activity
0.49	GO:0046577	long-chain-alcohol oxidase activity
0.46	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity
0.33	GO:0005515	protein binding
0.32	GO:1901265	nucleoside phosphate binding
0.32	GO:0036094	small molecule binding

0.50	GO:0005783	endoplasmic reticulum
0.46	GO:0005829	cytosol
0.41	GO:0005886	plasma membrane
0.39	GO:0031090	organelle membrane
0.39	GO:0005740	mitochondrial envelope
0.36	GO:0005615	extracellular space
0.36	GO:0042579	microbody
0.35	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.34	GO:0031984	organelle subcompartment
0.34	GO:1903561	extracellular vesicle

0.76

EC:1.2.1.5

GO:0004030

sp|P30872|SSR1_HUMAN
Somatostatin receptor type 1
Search

SSTR1

0.97	Somatostatin receptor type 1 subtype A

0.86	GO:0038169	somatostatin receptor signaling pathway
0.77	GO:0009755	hormone-mediated signaling pathway
0.55	GO:0007218	neuropeptide signaling pathway
0.54	GO:1990823	response to leukemia inhibitory factor
0.51	GO:0071345	cellular response to cytokine stimulus
0.51	GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
0.51	GO:0007215	glutamate receptor signaling pathway
0.49	GO:0071392	cellular response to estradiol stimulus
0.48	GO:0008285	negative regulation of cell proliferation
0.44	GO:0071385	cellular response to glucocorticoid stimulus

0.86	GO:0004994	somatostatin receptor activity
0.52	GO:0042923	neuropeptide binding
0.43	GO:0030165	PDZ domain binding
0.36	GO:0046982	protein heterodimerization activity
0.36	GO:0017046	peptide hormone binding
0.35	GO:0042803	protein homodimerization activity
0.33	GO:0004985	opioid receptor activity

0.48	GO:0043005	neuron projection
0.44	GO:0005886	plasma membrane
0.39	GO:0005829	cytosol
0.36	GO:0043235	receptor complex
0.30	GO:0016021	integral component of membrane

sp|P30874|SSR2_HUMAN
Somatostatin receptor type 2
Search

SSTR2

0.97	Somatostatin receptor type 2

0.85	GO:0038169	somatostatin receptor signaling pathway
0.76	GO:0009755	hormone-mediated signaling pathway
0.56	GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
0.53	GO:0007218	neuropeptide signaling pathway
0.50	GO:0071385	cellular response to glucocorticoid stimulus
0.50	GO:0071392	cellular response to estradiol stimulus
0.48	GO:0008285	negative regulation of cell proliferation
0.39	GO:0030432	peristalsis
0.38	GO:0021549	cerebellum development
0.38	GO:0006937	regulation of muscle contraction

0.85	GO:0004994	somatostatin receptor activity
0.56	GO:0030165	PDZ domain binding
0.52	GO:0042923	neuropeptide binding
0.34	GO:0017046	peptide hormone binding
0.34	GO:0046982	protein heterodimerization activity

0.48	GO:0005829	cytosol
0.47	GO:0043005	neuron projection
0.43	GO:0005887	integral component of plasma membrane
0.35	GO:0098802	plasma membrane receptor complex

sp|P30876|RPB2_HUMAN
DNA-directed RNA polymerase II subunit RPB2
Search

POLR2B

0.41	DNA-directed RNA polymerase subunit beta

0.58	GO:0006351	transcription, DNA-templated
0.35	GO:0035019	somatic stem cell population maintenance
0.35	GO:0060964	regulation of gene silencing by miRNA
0.34	GO:0008543	fibroblast growth factor receptor signaling pathway
0.34	GO:0016073	snRNA metabolic process
0.34	GO:0050434	positive regulation of viral transcription
0.34	GO:0006283	transcription-coupled nucleotide-excision repair
0.34	GO:0000398	mRNA splicing, via spliceosome
0.34	GO:0006370	7-methylguanosine mRNA capping

0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.65	GO:0001882	nucleoside binding
0.54	GO:0003677	DNA binding
0.50	GO:0003682	chromatin binding
0.34	GO:0005515	protein binding
0.34	GO:0003723	RNA binding
0.34	GO:0046872	metal ion binding

0.54	GO:0005665	DNA-directed RNA polymerase II, core complex
0.53	GO:0000784	nuclear chromosome, telomeric region
0.30	GO:0031224	intrinsic component of membrane

0.70

GO:0003899

sp|P30926|ACHB4_HUMAN
Neuronal acetylcholine receptor subunit beta-4
Search

CHRNB4

0.95	Neuronal acetylcholine receptor subunit beta-4

0.79	GO:0060079	excitatory postsynaptic potential
0.64	GO:0060084	synaptic transmission involved in micturition
0.61	GO:0035094	response to nicotine
0.60	GO:0034220	ion transmembrane transport
0.56	GO:0006939	smooth muscle contraction
0.56	GO:0001508	action potential
0.56	GO:0030534	adult behavior
0.54	GO:0051971	positive regulation of transmission of nerve impulse
0.54	GO:0007626	locomotory behavior
0.52	GO:0006940	regulation of smooth muscle contraction

0.83	GO:0022848	acetylcholine-gated cation-selective channel activity
0.70	GO:0004888	transmembrane signaling receptor activity
0.57	GO:0042166	acetylcholine binding
0.40	GO:0046982	protein heterodimerization activity

0.79	GO:0045211	postsynaptic membrane
0.74	GO:0030054	cell junction
0.64	GO:0005892	acetylcholine-gated channel complex
0.44	GO:0009897	external side of plasma membrane
0.39	GO:0043005	neuron projection
0.36	GO:0035579	specific granule membrane
0.36	GO:0070821	tertiary granule membrane
0.36	GO:0044853	plasma membrane raft

sp|P30939|5HT1F_HUMAN
5-hydroxytryptamine receptor 1F
Search

HTR1F

0.97	5-hydroxytryptamine (Serotonin) receptor 1F

0.85	GO:0098664	G-protein coupled serotonin receptor signaling pathway
0.74	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.37	GO:0098916	anterograde trans-synaptic signaling

0.85	GO:0004993	G-protein coupled serotonin receptor activity
0.76	GO:0051378	serotonin binding

0.67

GO:0005887

integral component of plasma membrane

sp|P30953|OR1E1_HUMAN
Olfactory receptor 1E1
Search

0.45	Olfactory receptor

0.75	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.70	GO:0007186	G-protein coupled receptor signaling pathway

0.75	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P30954|O10J1_HUMAN
Olfactory receptor 10J1
Search

0.38	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.42	GO:0007210	serotonin receptor signaling pathway
0.35	GO:0007338	single fertilization

0.76	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity
0.42	GO:0099589	serotonin receptor activity
0.40	GO:0030594	neurotransmitter receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P30968|GNRHR_HUMAN
Gonadotropin-releasing hormone receptor
Search

GNRHR

0.86	Pituitary gonadotropin releasing hormone receptor

0.78	GO:0097211	cellular response to gonadotropin-releasing hormone
0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.37	GO:0021764	amygdala development
0.36	GO:0060996	dendritic spine development
0.36	GO:0021766	hippocampus development
0.36	GO:0007612	learning
0.36	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.36	GO:0007626	locomotory behavior
0.36	GO:0007623	circadian rhythm
0.35	GO:0008285	negative regulation of cell proliferation

0.83	GO:0016500	protein-hormone receptor activity
0.71	GO:0004930	G-protein coupled receptor activity
0.45	GO:0042277	peptide binding
0.38	GO:0008641	ubiquitin-like modifier activating enzyme activity
0.36	GO:0001653	peptide receptor activity
0.34	GO:0005515	protein binding

0.42	GO:0005887	integral component of plasma membrane
0.32	GO:0005737	cytoplasm

sp|P30988|CALCR_HUMAN
Calcitonin receptor
Search

CALCR

0.90	Calcitonin receptor like receptor

0.70	GO:0007166	cell surface receptor signaling pathway
0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.55	GO:0019933	cAMP-mediated signaling
0.53	GO:0030316	osteoclast differentiation
0.53	GO:0030279	negative regulation of ossification
0.52	GO:0043488	regulation of mRNA stability
0.52	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.42	GO:0071329	cellular response to sucrose stimulus
0.42	GO:0031623	receptor internalization
0.41	GO:0007202	activation of phospholipase C activity

0.86	GO:0004948	calcitonin receptor activity
0.46	GO:0097644	calcitonin family binding
0.42	GO:0001635	calcitonin gene-related peptide receptor activity
0.42	GO:0001605	adrenomedullin receptor activity
0.40	GO:0008565	protein transporter activity
0.39	GO:0097643	amylin receptor activity
0.35	GO:0005515	protein binding
0.34	GO:0008144	drug binding

0.52	GO:0005886	plasma membrane
0.52	GO:0001669	acrosomal vesicle
0.49	GO:0005929	cilium
0.41	GO:0043235	receptor complex
0.39	GO:0005764	lysosome
0.39	GO:0005768	endosome
0.38	GO:0005783	endoplasmic reticulum
0.34	GO:0043025	neuronal cell body
0.34	GO:0030424	axon
0.30	GO:0016021	integral component of membrane

sp|P30989|NTR1_HUMAN
Neurotensin receptor type 1
Search

NTSR1

0.96	Neurotensin receptor type 1

0.80	GO:0007218	neuropeptide signaling pathway
0.66	GO:0008344	adult locomotory behavior
0.62	GO:0043066	negative regulation of apoptotic process
0.46	GO:0014054	positive regulation of gamma-aminobutyric acid secretion
0.46	GO:0097151	positive regulation of inhibitory postsynaptic potential
0.46	GO:0090238	positive regulation of arachidonic acid secretion
0.46	GO:0014049	positive regulation of glutamate secretion
0.46	GO:0070777	D-aspartate transport
0.45	GO:0098712	L-glutamate import across plasma membrane
0.45	GO:0060732	positive regulation of inositol phosphate biosynthetic process

0.87	GO:0016492	G-protein coupled neurotensin receptor activity
0.59	GO:0042802	identical protein binding
0.44	GO:0047485	protein N-terminus binding
0.41	GO:0046982	protein heterodimerization activity

0.63	GO:0098857	membrane microdomain
0.54	GO:0005887	integral component of plasma membrane
0.46	GO:0032280	symmetric synapse
0.44	GO:0043198	dendritic shaft
0.44	GO:0043204	perikaryon
0.44	GO:0043195	terminal bouton
0.44	GO:0043197	dendritic spine
0.41	GO:0009898	cytoplasmic side of plasma membrane
0.41	GO:0009986	cell surface
0.40	GO:0005794	Golgi apparatus

sp|P30990|NEUT_HUMAN
Neurotensin/neuromedin N
Search

NTS

0.97	Neurotensin/neuromedin N

0.76	GO:0010469	regulation of receptor activity
0.43	GO:0050880	regulation of blood vessel size
0.37	GO:0097332	response to antipsychotic drug
0.37	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
0.37	GO:0051412	response to corticosterone
0.37	GO:0071285	cellular response to lithium ion
0.37	GO:0071549	cellular response to dexamethasone stimulus
0.37	GO:0001975	response to amphetamine
0.37	GO:1990090	cellular response to nerve growth factor stimulus
0.36	GO:0042220	response to cocaine

0.85

GO:0005184

neuropeptide hormone activity

0.66	GO:0005576	extracellular region
0.51	GO:0043679	axon terminus
0.42	GO:0030133	transport vesicle
0.36	GO:0043025	neuronal cell body
0.30	GO:0016020	membrane

sp|P31025|LCN1_HUMAN
Lipocalin-1
Search

0.74	von Ebner gland protein 2

0.44	GO:0050909	sensory perception of taste
0.42	GO:0001895	retina homeostasis
0.39	GO:0015909	long-chain fatty acid transport
0.38	GO:0010951	negative regulation of endopeptidase activity
0.37	GO:0050896	response to stimulus
0.35	GO:0006508	proteolysis

0.52	GO:0031404	chloride ion binding
0.51	GO:0036094	small molecule binding
0.46	GO:0005102	receptor binding
0.42	GO:0008270	zinc ion binding
0.39	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.37	GO:0043621	protein self-association
0.36	GO:0042803	protein homodimerization activity

0.47	GO:0005615	extracellular space
0.41	GO:1903561	extracellular vesicle

sp|P31040|SDHA_HUMAN
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Search

SDHA

0.68	Succinate dehydrogenase [ubiquinone] flavoprotein subunit A, mitochondrial

0.70	GO:0006099	tricarboxylic acid cycle
0.60	GO:0022900	electron transport chain
0.52	GO:0006105	succinate metabolic process
0.47	GO:0007399	nervous system development
0.44	GO:0009061	anaerobic respiration
0.40	GO:0006119	oxidative phosphorylation
0.36	GO:0006106	fumarate metabolic process
0.34	GO:0007034	vacuolar transport

0.78	GO:0008177	succinate dehydrogenase (ubiquinone) activity
0.65	GO:0050660	flavin adenine dinucleotide binding
0.40	GO:0009055	electron transfer activity
0.36	GO:0004333	fumarate hydratase activity
0.35	GO:0005515	protein binding

0.56	GO:0031966	mitochondrial membrane
0.56	GO:0019866	organelle inner membrane
0.49	GO:0045282	plasma membrane succinate dehydrogenase complex
0.49	GO:0043209	myelin sheath
0.49	GO:0045257	succinate dehydrogenase complex (ubiquinone)
0.49	GO:0045283	fumarate reductase complex
0.47	GO:0005730	nucleolus
0.45	GO:0098798	mitochondrial protein complex
0.36	GO:0045239	tricarboxylic acid cycle enzyme complex
0.30	GO:0016021	integral component of membrane

0.78	EC:1.3.5.1	GO:0008177
0.78	KEGG:R02164	GO:0008177

sp|P31146|COR1A_HUMAN
Coronin-1A
Search

CORO1A

0.69

Coronin

0.74	GO:0001845	phagolysosome assembly
0.70	GO:0030595	leukocyte chemotaxis
0.64	GO:0030036	actin cytoskeleton organization
0.61	GO:0061502	early endosome to recycling endosome transport
0.61	GO:0032796	uropod organization
0.60	GO:0038180	nerve growth factor signaling pathway
0.59	GO:0043320	natural killer cell degranulation
0.59	GO:0031339	negative regulation of vesicle fusion
0.58	GO:0071353	cellular response to interleukin-4
0.58	GO:0048873	homeostasis of number of cells within a tissue

0.75	GO:0051015	actin filament binding
0.59	GO:0032036	myosin heavy chain binding
0.57	GO:0043548	phosphatidylinositol 3-kinase binding
0.56	GO:0003785	actin monomer binding
0.55	GO:0008022	protein C-terminus binding
0.52	GO:0042802	identical protein binding
0.48	GO:0046983	protein dimerization activity
0.46	GO:0048365	Rac GTPase binding
0.38	GO:0071933	Arp2/3 complex binding
0.37	GO:0045296	cadherin binding

0.64	GO:0015629	actin cytoskeleton
0.59	GO:0030027	lamellipodium
0.57	GO:0001891	phagocytic cup
0.57	GO:0001772	immunological synapse
0.56	GO:0045335	phagocytic vesicle
0.54	GO:0005769	early endosome
0.54	GO:0030424	axon
0.54	GO:0030863	cortical cytoskeleton
0.52	GO:0005911	cell-cell junction
0.51	GO:0099513	polymeric cytoskeletal fiber

sp|P31150|GDIA_HUMAN
Rab GDP dissociation inhibitor alpha
Search

GDI1

0.68	Rab GDP dissociation inhibitor alpha

0.77	GO:0007264	small GTPase mediated signal transduction
0.75	GO:0043547	positive regulation of GTPase activity
0.65	GO:0015031	protein transport
0.55	GO:0090315	negative regulation of protein targeting to membrane
0.43	GO:0050771	negative regulation of axonogenesis
0.39	GO:0045773	positive regulation of axon extension
0.39	GO:0051592	response to calcium ion
0.35	GO:0051056	regulation of small GTPase mediated signal transduction
0.35	GO:0043312	neutrophil degranulation

0.85	GO:0005093	Rab GDP-dissociation inhibitor activity
0.76	GO:0005096	GTPase activator activity
0.39	GO:0031267	small GTPase binding
0.33	GO:0003723	RNA binding
0.32	GO:0016740	transferase activity

0.54	GO:0043209	myelin sheath
0.50	GO:0030496	midbody
0.49	GO:0005737	cytoplasm
0.42	GO:0012505	endomembrane system
0.38	GO:0043227	membrane-bounded organelle
0.38	GO:0043025	neuronal cell body
0.38	GO:0030424	axon
0.37	GO:0043229	intracellular organelle
0.35	GO:0043234	protein complex
0.34	GO:0005925	focal adhesion

0.32

GO:0016740

sp|P31151|S10A7_HUMAN
Protein S100-A7
Search

0.46	GO:0010820	positive regulation of T cell chemotaxis
0.45	GO:0090026	positive regulation of monocyte chemotaxis
0.45	GO:0071624	positive regulation of granulocyte chemotaxis
0.45	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
0.45	GO:0051238	sequestering of metal ion
0.44	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.44	GO:0050829	defense response to Gram-negative bacterium
0.44	GO:0032496	response to lipopolysaccharide
0.42	GO:0000302	response to reactive oxygen species
0.39	GO:0043312	neutrophil degranulation

0.70	GO:0005509	calcium ion binding
0.57	GO:0046914	transition metal ion binding
0.46	GO:0050786	RAGE receptor binding
0.42	GO:0043621	protein self-association
0.34	GO:0005198	structural molecule activity

0.45	GO:0005615	extracellular space
0.42	GO:0031012	extracellular matrix
0.41	GO:0005783	endoplasmic reticulum
0.40	GO:0005829	cytosol
0.40	GO:0035578	azurophil granule lumen
0.38	GO:0005634	nucleus
0.38	GO:0005925	focal adhesion
0.38	GO:1903561	extracellular vesicle

sp|P31152|MK04_HUMAN
Mitogen-activated protein kinase 4
Search

MAPK4

0.93	Extracellular signal-regulated kinase 4

0.79	GO:0000165	MAPK cascade
0.47	GO:0071310	cellular response to organic substance
0.45	GO:0060999	positive regulation of dendritic spine development
0.40	GO:0060255	regulation of macromolecule metabolic process
0.37	GO:0007049	cell cycle

0.81	GO:0004707	MAP kinase activity
0.56	GO:0019901	protein kinase binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0046982	protein heterodimerization activity
0.51	GO:0042803	protein homodimerization activity

0.49	GO:0005634	nucleus
0.44	GO:0032156	septin cytoskeleton
0.42	GO:0005829	cytosol
0.38	GO:0043234	protein complex
0.35	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.81	EC:2.7.11.24	GO:0004707
0.81	KEGG:R00162	GO:0004707

sp|P31153|METK2_HUMAN
S-adenosylmethionine synthase isoform type-2
Search

MAT2A

0.54	S-adenosylmethionine synthase

0.78	GO:0006556	S-adenosylmethionine biosynthetic process
0.72	GO:0006730	one-carbon metabolic process
0.55	GO:0034214	protein hexamerization
0.53	GO:0051291	protein heterooligomerization
0.52	GO:1990830	cellular response to leukemia inhibitory factor
0.43	GO:0009087	methionine catabolic process
0.42	GO:0055013	cardiac muscle cell development
0.41	GO:0051289	protein homotetramerization
0.41	GO:0072358	cardiovascular system development
0.35	GO:0051591	response to cAMP

0.79	GO:0004478	methionine adenosyltransferase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0046872	metal ion binding
0.50	GO:0042802	identical protein binding
0.35	GO:0016597	amino acid binding
0.34	GO:0008488	gamma-glutamyl carboxylase activity
0.33	GO:0046983	protein dimerization activity

0.58	GO:0048269	methionine adenosyltransferase complex
0.43	GO:0005829	cytosol
0.34	GO:0016363	nuclear matrix
0.30	GO:0016020	membrane

0.79

EC:2.5.1.6

GO:0004478

sp|P31213|S5A2_HUMAN
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Search

SRD5A2

0.97	Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)

0.69	GO:0008202	steroid metabolic process
0.58	GO:0008584	male gonad development
0.57	GO:0030539	male genitalia development
0.55	GO:0042446	hormone biosynthetic process
0.55	GO:0034754	cellular hormone metabolic process
0.52	GO:0055114	oxidation-reduction process
0.52	GO:1901617	organic hydroxy compound biosynthetic process
0.52	GO:0042181	ketone biosynthetic process
0.49	GO:0008610	lipid biosynthetic process
0.49	GO:0030540	female genitalia development

0.77	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity
0.63	GO:0009917	sterol 5-alpha reductase activity
0.62	GO:0030283	testosterone dehydrogenase [NAD(P)] activity
0.45	GO:0047751	cholestenone 5-alpha-reductase activity
0.37	GO:0033218	amide binding

0.49	GO:0005737	cytoplasm
0.41	GO:0070852	cell body fiber
0.39	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.39	GO:0043025	neuronal cell body
0.38	GO:0031984	organelle subcompartment
0.37	GO:0031090	organelle membrane
0.36	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

0.77	EC:1.3.99.5	GO:0003865
0.45	KEGG:R02610	GO:0047751

sp|P31249|HXD3_HUMAN
Homeobox protein Hox-D3
Search

HOXD3

0.94	Homeobox protein Hox-D3

0.68	GO:0007275	multicellular organism development
0.58	GO:0061448	connective tissue development
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.55	GO:0007219	Notch signaling pathway
0.55	GO:0007160	cell-matrix adhesion
0.54	GO:0051960	regulation of nervous system development
0.54	GO:0060284	regulation of cell development
0.53	GO:0045597	positive regulation of cell differentiation

0.63	GO:0043565	sequence-specific DNA binding
0.60	GO:0003700	DNA binding transcription factor activity
0.54	GO:0001012	RNA polymerase II regulatory region DNA binding
0.51	GO:0003690	double-stranded DNA binding
0.40	GO:0071837	HMG box domain binding

0.60	GO:0005634	nucleus
0.57	GO:0016235	aggresome
0.49	GO:0043233	organelle lumen
0.44	GO:0044446	intracellular organelle part

sp|P31260|HXA10_HUMAN
Homeobox protein Hox-A10
Search

0.93	LOW QUALITY PROTEIN: homeobox protein Hox-C10

0.64	GO:0009954	proximal/distal pattern formation
0.62	GO:0030326	embryonic limb morphogenesis
0.60	GO:0009952	anterior/posterior pattern specification
0.59	GO:0001501	skeletal system development
0.59	GO:0060065	uterus development
0.57	GO:0008584	male gonad development
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:0006366	transcription by RNA polymerase II
0.56	GO:0007338	single fertilization

0.64	GO:0043565	sequence-specific DNA binding
0.60	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.58	GO:0001012	RNA polymerase II regulatory region DNA binding
0.57	GO:0042826	histone deacetylase binding
0.55	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.54	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.52	GO:0005667	transcription factor complex
0.47	GO:0150005	enzyme activator complex
0.47	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
0.42	GO:0043233	organelle lumen
0.39	GO:0005737	cytoplasm
0.39	GO:0044446	intracellular organelle part

sp|P31267|HXA6_HUMAN
Homeobox protein Hox-A6
Search

HOXA6

0.97	Homeobox protein Hox-A6

0.67	GO:0007275	multicellular organism development
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.52	GO:0009653	anatomical structure morphogenesis
0.38	GO:0034101	erythrocyte homeostasis
0.37	GO:0006351	transcription, DNA-templated
0.34	GO:0048863	stem cell differentiation
0.33	GO:0045617	negative regulation of keratinocyte differentiation
0.33	GO:0045656	negative regulation of monocyte differentiation

0.63	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.33	GO:0001012	RNA polymerase II regulatory region DNA binding
0.32	GO:0008134	transcription factor binding
0.32	GO:0003690	double-stranded DNA binding

0.60	GO:0005634	nucleus
0.32	GO:0012505	endomembrane system
0.32	GO:0031974	membrane-enclosed lumen
0.32	GO:0031967	organelle envelope
0.32	GO:0031090	organelle membrane

sp|P31268|HXA7_HUMAN
Homeobox protein Hox-A7
Search

HOXA7

0.96	Homeobox protein Hox-A7 (Predicted)

0.66	GO:0007275	multicellular organism development
0.63	GO:0045617	negative regulation of keratinocyte differentiation
0.62	GO:0045656	negative regulation of monocyte differentiation
0.60	GO:0002686	negative regulation of leukocyte migration
0.60	GO:0001953	negative regulation of cell-matrix adhesion
0.58	GO:0048863	stem cell differentiation
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.54	GO:0006366	transcription by RNA polymerase II

0.63	GO:0043565	sequence-specific DNA binding
0.59	GO:0003700	DNA binding transcription factor activity
0.55	GO:0001012	RNA polymerase II regulatory region DNA binding
0.52	GO:0008134	transcription factor binding
0.52	GO:0003690	double-stranded DNA binding
0.34	GO:0042803	protein homodimerization activity

0.60	GO:0005634	nucleus
0.50	GO:0012505	endomembrane system
0.49	GO:0031974	membrane-enclosed lumen
0.47	GO:0031967	organelle envelope
0.46	GO:0031090	organelle membrane

sp|P31269|HXA9_HUMAN
Homeobox protein Hox-A9
Search

HOXA9

0.74	Homeobox protein Hox-A9

0.64	GO:0007275	multicellular organism development
0.58	GO:0045638	negative regulation of myeloid cell differentiation
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0007338	single fertilization
0.56	GO:0006351	transcription, DNA-templated
0.56	GO:0010468	regulation of gene expression
0.55	GO:0007548	sex differentiation
0.55	GO:0042118	endothelial cell activation
0.55	GO:0007283	spermatogenesis

0.64	GO:0043565	sequence-specific DNA binding
0.53	GO:0001012	RNA polymerase II regulatory region DNA binding
0.51	GO:0003690	double-stranded DNA binding
0.47	GO:0019899	enzyme binding
0.36	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.52	GO:0005667	transcription factor complex
0.39	GO:0005737	cytoplasm
0.38	GO:0016235	aggresome
0.35	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part

sp|P31270|HXA11_HUMAN
Homeobox protein Hox-A11
Search

HOXA11

0.93	Homeobox protein Hox-A11 (Predicted)

0.61	GO:0007501	mesodermal cell fate specification
0.61	GO:0032332	positive regulation of chondrocyte differentiation
0.60	GO:0060272	embryonic skeletal joint morphogenesis
0.60	GO:0060351	cartilage development involved in endochondral bone morphogenesis
0.60	GO:0060065	uterus development
0.60	GO:0001759	organ induction
0.59	GO:0001658	branching involved in ureteric bud morphogenesis
0.59	GO:0035115	embryonic forelimb morphogenesis
0.59	GO:0009954	proximal/distal pattern formation
0.58	GO:0042733	embryonic digit morphogenesis

0.62	GO:0043565	sequence-specific DNA binding
0.34	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.53	GO:0005667	transcription factor complex
0.51	GO:0032993	protein-DNA complex
0.49	GO:0031974	membrane-enclosed lumen
0.44	GO:0044446	intracellular organelle part

sp|P31271|HXA13_HUMAN
Homeobox protein Hox-A13
Search

HOXA13

0.96	LOW QUALITY PROTEIN: homeobox protein Hox-A13

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.45	GO:0060173	limb development
0.43	GO:0007423	sensory organ development
0.43	GO:0009887	animal organ morphogenesis
0.43	GO:0060429	epithelium development
0.43	GO:0006366	transcription by RNA polymerase II
0.42	GO:0022405	hair cycle process
0.42	GO:1902680	positive regulation of RNA biosynthetic process

0.64	GO:0043565	sequence-specific DNA binding
0.46	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.40	GO:0003682	chromatin binding
0.40	GO:0035326	enhancer binding
0.39	GO:0001012	RNA polymerase II regulatory region DNA binding
0.38	GO:0003690	double-stranded DNA binding
0.35	GO:0005515	protein binding

0.61

GO:0005634

nucleus

sp|P31273|HXC8_HUMAN
Homeobox protein Hox-C8
Search

HOXC8

0.95	Homeobox protein pXhoxc8

0.66	GO:0007275	multicellular organism development
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:0009653	anatomical structure morphogenesis
0.49	GO:1902679	negative regulation of RNA biosynthetic process
0.49	GO:0030154	cell differentiation
0.37	GO:0006351	transcription, DNA-templated
0.37	GO:0008283	cell proliferation
0.37	GO:0016477	cell migration

0.63	GO:0043565	sequence-specific DNA binding
0.59	GO:0003700	DNA binding transcription factor activity
0.33	GO:0001012	RNA polymerase II regulatory region DNA binding
0.33	GO:0003690	double-stranded DNA binding

0.60	GO:0005634	nucleus
0.49	GO:0015630	microtubule cytoskeleton
0.47	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part

sp|P31274|HXC9_HUMAN
Homeobox protein Hox-C9
Search

HOXC9

0.91	Homeobox protein Hox-C9

0.64	GO:0007275	multicellular organism development
0.57	GO:0006351	transcription, DNA-templated
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.49	GO:0009653	anatomical structure morphogenesis
0.36	GO:2001213	negative regulation of vasculogenesis
0.35	GO:1901492	positive regulation of lymphangiogenesis
0.35	GO:0008344	adult locomotory behavior
0.35	GO:0007338	single fertilization

0.63	GO:0043565	sequence-specific DNA binding
0.35	GO:0003700	DNA binding transcription factor activity
0.34	GO:0001012	RNA polymerase II regulatory region DNA binding
0.34	GO:0003690	double-stranded DNA binding
0.33	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.57	GO:0016235	aggresome
0.48	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.33	GO:0043232	intracellular non-membrane-bounded organelle

sp|P31275|HXC12_HUMAN
Homeobox protein Hox-C12
Search

0.76	Homeobox protein Hox-C12 isoform B

0.54	GO:1903506	regulation of nucleic acid-templated transcription
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:0010468	regulation of gene expression
0.37	GO:0007275	multicellular organism development
0.35	GO:0097659	nucleic acid-templated transcription
0.34	GO:0010467	gene expression
0.34	GO:0034645	cellular macromolecule biosynthetic process

0.61

GO:0043565

sequence-specific DNA binding

0.59

GO:0005634

nucleus

sp|P31276|HXC13_HUMAN
Homeobox protein Hox-C13
Search

0.96	Transcription factor HoxC13

0.58	GO:0043587	tongue morphogenesis
0.58	GO:0035878	nail development
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.55	GO:0001942	hair follicle development
0.53	GO:0009952	anterior/posterior pattern specification
0.51	GO:0006366	transcription by RNA polymerase II
0.50	GO:1902680	positive regulation of RNA biosynthetic process
0.37	GO:2001055	positive regulation of mesenchymal cell apoptotic process

0.63	GO:0043565	sequence-specific DNA binding
0.54	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.51	GO:0003682	chromatin binding
0.36	GO:0035326	enhancer binding
0.35	GO:0001012	RNA polymerase II regulatory region DNA binding
0.35	GO:0003690	double-stranded DNA binding
0.34	GO:0005515	protein binding
0.34	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding

0.60

GO:0005634

nucleus

sp|P31277|HXD11_HUMAN
Homeobox protein Hox-D11
Search

0.90	Homeobox protein Hox-D11

0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:0010468	regulation of gene expression
0.41	GO:0001658	branching involved in ureteric bud morphogenesis
0.41	GO:0009953	dorsal/ventral pattern formation
0.39	GO:0060272	embryonic skeletal joint morphogenesis
0.39	GO:0032332	positive regulation of chondrocyte differentiation
0.39	GO:0001759	organ induction
0.39	GO:0060351	cartilage development involved in endochondral bone morphogenesis
0.39	GO:0035115	embryonic forelimb morphogenesis

0.65	GO:0043565	sequence-specific DNA binding
0.33	GO:0003700	DNA binding transcription factor activity

0.61	GO:0005634	nucleus
0.48	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.33	GO:0005667	transcription factor complex
0.33	GO:0032993	protein-DNA complex

sp|P31314|TLX1_HUMAN
T-cell leukemia homeobox protein 1
Search

TLX1

0.96	T-cell leukemia homeobox protein 1

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:0006366	transcription by RNA polymerase II
0.52	GO:0051254	positive regulation of RNA metabolic process
0.52	GO:0010557	positive regulation of macromolecule biosynthetic process
0.52	GO:0031328	positive regulation of cellular biosynthetic process
0.49	GO:0002087	regulation of respiratory gaseous exchange by neurological system process
0.48	GO:0007585	respiratory gaseous exchange
0.47	GO:0048665	neuron fate specification

0.64	GO:0043565	sequence-specific DNA binding
0.56	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.54	GO:0001012	RNA polymerase II regulatory region DNA binding
0.51	GO:0003690	double-stranded DNA binding
0.37	GO:0005515	protein binding
0.33	GO:0005198	structural molecule activity

0.61	GO:0005634	nucleus
0.42	GO:0043233	organelle lumen
0.39	GO:0044446	intracellular organelle part
0.34	GO:0045111	intermediate filament cytoskeleton
0.33	GO:0099512	supramolecular fiber
0.32	GO:0005737	cytoplasm

sp|P31321|KAP1_HUMAN
cAMP-dependent protein kinase type I-beta regulatory subunit
Search

PRKAR1B

0.93	cAMP-dependent protein kinase type I-alpha regulatory subunit

0.74	GO:0045859	regulation of protein kinase activity
0.58	GO:0033673	negative regulation of kinase activity
0.55	GO:0001933	negative regulation of protein phosphorylation
0.52	GO:0007611	learning or memory
0.52	GO:0046007	negative regulation of activated T cell proliferation
0.51	GO:0016310	phosphorylation
0.50	GO:0060038	cardiac muscle cell proliferation
0.49	GO:0045214	sarcomere organization
0.48	GO:0001707	mesoderm formation
0.37	GO:0007143	female meiotic nuclear division

0.84	GO:0008603	cAMP-dependent protein kinase regulator activity
0.82	GO:0030552	cAMP binding
0.62	GO:0034236	protein kinase A catalytic subunit binding
0.62	GO:0004862	cAMP-dependent protein kinase inhibitor activity
0.53	GO:0016301	kinase activity
0.47	GO:0031625	ubiquitin protein ligase binding
0.46	GO:0019904	protein domain specific binding
0.34	GO:0008083	growth factor activity
0.34	GO:0042802	identical protein binding

0.82	GO:0005952	cAMP-dependent protein kinase complex
0.50	GO:0001772	immunological synapse
0.50	GO:0031588	nucleotide-activated protein kinase complex
0.49	GO:0044853	plasma membrane raft
0.48	GO:0005930	axoneme
0.48	GO:0031594	neuromuscular junction
0.36	GO:0097546	ciliary base
0.34	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

sp|P31323|KAP3_HUMAN
cAMP-dependent protein kinase type II-beta regulatory subunit
Search

PRKAR2B

0.97	cAMP-dependent protein kinase type II-beta regulatory subunit

0.75	GO:0045859	regulation of protein kinase activity
0.57	GO:0033673	negative regulation of kinase activity
0.55	GO:0007612	learning
0.54	GO:0001933	negative regulation of protein phosphorylation
0.51	GO:0016310	phosphorylation
0.48	GO:0006631	fatty acid metabolic process
0.42	GO:0097338	response to clozapine
0.37	GO:0071377	cellular response to glucagon stimulus
0.37	GO:0003091	renal water homeostasis
0.36	GO:0007596	blood coagulation

0.85	GO:0008603	cAMP-dependent protein kinase regulator activity
0.84	GO:0030552	cAMP binding
0.61	GO:0034236	protein kinase A catalytic subunit binding
0.60	GO:0004862	cAMP-dependent protein kinase inhibitor activity
0.56	GO:0031625	ubiquitin protein ligase binding
0.53	GO:0016301	kinase activity
0.45	GO:0019904	protein domain specific binding
0.33	GO:0031698	beta-2 adrenergic receptor binding
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0042803	protein homodimerization activity

0.83	GO:0005952	cAMP-dependent protein kinase complex
0.57	GO:0097546	ciliary base
0.57	GO:0043198	dendritic shaft
0.56	GO:0043197	dendritic spine
0.55	GO:0005813	centrosome
0.46	GO:0098857	membrane microdomain
0.45	GO:0031588	nucleotide-activated protein kinase complex
0.44	GO:0005930	axoneme
0.44	GO:0005886	plasma membrane
0.39	GO:0043025	neuronal cell body

sp|P31327|CPSM_HUMAN
Carbamoyl-phosphate synthase [ammonia], mitochondrial
Search

CPS1

0.63	Carbamoyl-phosphate synthetase I

0.71	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
0.68	GO:0006541	glutamine metabolic process
0.61	GO:0070409	carbamoyl phosphate biosynthetic process
0.60	GO:1903718	cellular response to ammonia
0.58	GO:0019433	triglyceride catabolic process
0.57	GO:0042311	vasodilation
0.56	GO:0046209	nitric oxide metabolic process
0.55	GO:0050667	homocysteine metabolic process
0.55	GO:0032496	response to lipopolysaccharide
0.54	GO:0000050	urea cycle

0.74	GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
0.66	GO:0004087	carbamoyl-phosphate synthase (ammonia) activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0046872	metal ion binding
0.51	GO:0072341	modified amino acid binding
0.40	GO:0016595	glutamate binding
0.37	GO:0005543	phospholipid binding
0.37	GO:0032403	protein complex binding

0.55	GO:0042645	mitochondrial nucleoid
0.51	GO:0005730	nucleolus
0.35	GO:0031966	mitochondrial membrane
0.35	GO:0019866	organelle inner membrane
0.35	GO:0043234	protein complex

0.74	EC:6.3.5.5	GO:0004088
0.66	KEGG:R00149	GO:0004087

sp|P31350|RIR2_HUMAN
Ribonucleoside-diphosphate reductase subunit M2
Search

RRM2

0.85	LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2

0.74	GO:0009263	deoxyribonucleotide biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.47	GO:0051290	protein heterotetramerization
0.43	GO:0006264	mitochondrial DNA replication
0.43	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
0.42	GO:0003014	renal system process
0.41	GO:0001822	kidney development
0.40	GO:0009200	deoxyribonucleoside triphosphate metabolic process
0.39	GO:0006979	response to oxidative stress
0.37	GO:0006281	DNA repair

0.54	GO:0016491	oxidoreductase activity
0.43	GO:0008199	ferric iron binding
0.43	GO:0042803	protein homodimerization activity

0.51	GO:0005971	ribonucleoside-diphosphate reductase complex
0.38	GO:0005654	nucleoplasm
0.37	GO:0005739	mitochondrion
0.34	GO:0005635	nuclear envelope
0.30	GO:0031224	intrinsic component of membrane

0.54

GO:0016491

sp|P31358|CD52_HUMAN
CAMPATH-1 antigen
Search

CD52

0.96	CAMPATH-1 antigen

0.74	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.61	GO:0045730	respiratory burst
0.61	GO:0006501	C-terminal protein lipidation

0.72	GO:0031225	anchored component of membrane
0.52	GO:0005886	plasma membrane
0.49	GO:0005576	extracellular region
0.48	GO:0097225	sperm midpiece
0.30	GO:0016021	integral component of membrane

sp|P31371|FGF9_HUMAN
Fibroblast growth factor 9
Search

FGF9

0.62	Fibroblast growth factor

0.82	GO:0008543	fibroblast growth factor receptor signaling pathway
0.75	GO:0010469	regulation of receptor activity
0.59	GO:0060043	regulation of cardiac muscle cell proliferation
0.58	GO:1904707	positive regulation of vascular smooth muscle cell proliferation
0.57	GO:0048839	inner ear development
0.56	GO:0060484	lung-associated mesenchyme development
0.56	GO:0032927	positive regulation of activin receptor signaling pathway
0.56	GO:0008584	male gonad development
0.56	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
0.56	GO:0048505	regulation of timing of cell differentiation

0.83	GO:0005104	fibroblast growth factor receptor binding
0.78	GO:0008083	growth factor activity
0.48	GO:0090722	receptor-receptor interaction
0.41	GO:0008201	heparin binding
0.38	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.37	GO:0016303	1-phosphatidylinositol-3-kinase activity
0.36	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.36	GO:0004713	protein tyrosine kinase activity
0.34	GO:0043395	heparan sulfate proteoglycan binding

0.65	GO:0005576	extracellular region
0.38	GO:0031982	vesicle
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.38	EC:2.7.1.153	GO:0046934
0.38	KEGG:R04545	GO:0046934

sp|P31391|SSR4_HUMAN
Somatostatin receptor type 4
Search

SSTR4

0.96	Somatostatin receptor subtype 1

0.86	GO:0038169	somatostatin receptor signaling pathway
0.77	GO:0009755	hormone-mediated signaling pathway
0.51	GO:1990830	cellular response to leukemia inhibitory factor
0.49	GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
0.49	GO:0007218	neuropeptide signaling pathway
0.48	GO:0071396	cellular response to lipid
0.48	GO:0071407	cellular response to organic cyclic compound
0.48	GO:0008285	negative regulation of cell proliferation
0.48	GO:0007215	glutamate receptor signaling pathway
0.46	GO:0051384	response to glucocorticoid

0.86	GO:0004994	somatostatin receptor activity
0.52	GO:0042923	neuropeptide binding
0.36	GO:0017046	peptide hormone binding
0.36	GO:0005515	protein binding

0.48	GO:0043005	neuron projection
0.44	GO:0005887	integral component of plasma membrane
0.35	GO:0098802	plasma membrane receptor complex
0.35	GO:0005737	cytoplasm

sp|P31415|CASQ1_HUMAN
Calsequestrin-1
Search

CASQ1

0.90	Calsequestrin

0.57	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
0.56	GO:1901341	positive regulation of store-operated calcium channel activity
0.55	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
0.55	GO:0045214	sarcomere organization
0.55	GO:2001256	regulation of store-operated calcium entry
0.52	GO:0051258	protein polymerization
0.51	GO:0007029	endoplasmic reticulum organization
0.48	GO:0009408	response to heat
0.41	GO:0051208	sequestering of calcium ion
0.41	GO:0071313	cellular response to caffeine

0.70	GO:0005509	calcium ion binding
0.49	GO:0042802	identical protein binding
0.40	GO:0048306	calcium-dependent protein binding
0.35	GO:0005391	sodium:potassium-exchanging ATPase activity
0.34	GO:0030955	potassium ion binding
0.34	GO:0046983	protein dimerization activity
0.33	GO:0000287	magnesium ion binding
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0008144	drug binding

0.59	GO:0033018	sarcoplasmic reticulum lumen
0.49	GO:0005759	mitochondrial matrix
0.45	GO:0031674	I band
0.42	GO:0014802	terminal cisterna
0.41	GO:0033017	sarcoplasmic reticulum membrane
0.40	GO:0030314	junctional membrane complex
0.39	GO:0030315	T-tubule
0.36	GO:0005794	Golgi apparatus
0.35	GO:0005790	smooth endoplasmic reticulum
0.33	GO:0030529	intracellular ribonucleoprotein complex

0.35

EC:3.6.3.9

GO:0005391

sp|P31431|SDC4_HUMAN
Syndecan-4
Search

SDC4

0.81

Syndecan

0.63	GO:1903553	positive regulation of extracellular exosome assembly
0.62	GO:1903543	positive regulation of exosomal secretion
0.61	GO:0010762	regulation of fibroblast migration
0.61	GO:0042060	wound healing
0.60	GO:0060122	inner ear receptor cell stereocilium organization
0.60	GO:0042130	negative regulation of T cell proliferation
0.60	GO:0002009	morphogenesis of an epithelium
0.59	GO:0060606	tube closure
0.58	GO:0021915	neural tube development
0.56	GO:0048598	embryonic morphogenesis

0.63	GO:0070053	thrombospondin receptor activity
0.53	GO:0042802	identical protein binding
0.42	GO:0005080	protein kinase C binding
0.41	GO:0001968	fibronectin binding
0.38	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.37	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.36	GO:0043395	heparan sulfate proteoglycan binding
0.34	GO:0046983	protein dimerization activity
0.34	GO:0030554	adenyl nucleotide binding
0.33	GO:0008144	drug binding

0.54	GO:0009986	cell surface
0.42	GO:0005925	focal adhesion
0.41	GO:0043034	costamere
0.39	GO:0098857	membrane microdomain
0.38	GO:0005796	Golgi lumen
0.38	GO:0005576	extracellular region
0.36	GO:0043202	lysosomal lumen
0.36	GO:0031982	vesicle
0.35	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.37

EC:2.7.10.1

GO:0004714

sp|P31483|TIA1_HUMAN
Nucleolysin TIA-1 isoform p40
Search

TIA1

0.83	Cytotoxic granule-associated RNA binding protein 1, like

0.57	GO:1903608	protein localization to cytoplasmic stress granule
0.55	GO:0042036	negative regulation of cytokine biosynthetic process
0.53	GO:0048024	regulation of mRNA splicing, via spliceosome
0.50	GO:0017148	negative regulation of translation
0.40	GO:1904037	positive regulation of epithelial cell apoptotic process
0.36	GO:0006915	apoptotic process
0.35	GO:0008543	fibroblast growth factor receptor signaling pathway
0.34	GO:0017145	stem cell division
0.34	GO:0007281	germ cell development
0.34	GO:0008284	positive regulation of cell proliferation

0.59	GO:0003723	RNA binding
0.34	GO:0003677	DNA binding
0.34	GO:0005515	protein binding

0.57	GO:0097165	nuclear stress granule
0.52	GO:0010494	cytoplasmic stress granule
0.48	GO:0005654	nucleoplasm
0.47	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|P31512|FMO4_HUMAN
Dimethylaniline monooxygenase [N-oxide-forming] 4
Search

0.61	Flavin-containing monooxygenase

0.55	GO:0070995	NADPH oxidation
0.50	GO:0072592	oxygen metabolic process
0.47	GO:0042737	drug catabolic process
0.46	GO:0009404	toxin metabolic process
0.44	GO:0006805	xenobiotic metabolic process
0.40	GO:0006082	organic acid metabolic process
0.34	GO:0032496	response to lipopolysaccharide
0.34	GO:0006970	response to osmotic stress

0.78	GO:0004499	N,N-dimethylaniline monooxygenase activity
0.70	GO:0050661	NADP binding
0.66	GO:0050660	flavin adenine dinucleotide binding
0.39	GO:0034899	trimethylamine monooxygenase activity
0.34	GO:0016597	amino acid binding

0.43	GO:0005789	endoplasmic reticulum membrane
0.40	GO:0031090	organelle membrane
0.30	GO:0016021	integral component of membrane

0.78	EC:1.14.13.8	GO:0004499
0.39	KEGG:R05623	GO:0034899

sp|P31513|FMO3_HUMAN
Dimethylaniline monooxygenase [N-oxide-forming] 3
Search

FMO3

0.60	Flavin-containing monooxygenase

0.52	GO:0055114	oxidation-reduction process
0.42	GO:0072592	oxygen metabolic process
0.41	GO:0006739	NADP metabolic process
0.40	GO:0009404	toxin metabolic process
0.40	GO:0006805	xenobiotic metabolic process
0.37	GO:0006082	organic acid metabolic process
0.36	GO:0042737	drug catabolic process

0.78	GO:0004499	N,N-dimethylaniline monooxygenase activity
0.69	GO:0050661	NADP binding
0.65	GO:0050660	flavin adenine dinucleotide binding
0.46	GO:0034899	trimethylamine monooxygenase activity
0.34	GO:0016597	amino acid binding
0.33	GO:0005515	protein binding

0.42	GO:0005783	endoplasmic reticulum
0.42	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.41	GO:0031984	organelle subcompartment
0.39	GO:0031090	organelle membrane
0.35	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.78	EC:1.14.13.8	GO:0004499
0.46	KEGG:R05623	GO:0034899

sp|P31629|ZEP2_HUMAN
Transcription factor HIVEP2
Search

HIVEP2

0.95	Transcription factor HIVEP2

0.37	GO:0006366	transcription by RNA polymerase II
0.36	GO:0007275	multicellular organism development
0.35	GO:0007165	signal transduction
0.34	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression

0.51	GO:0003676	nucleic acid binding
0.35	GO:0003700	DNA binding transcription factor activity
0.34	GO:0046872	metal ion binding

0.41	GO:0005654	nucleoplasm
0.36	GO:0005667	transcription factor complex

sp|P31639|SC5A2_HUMAN
Sodium/glucose cotransporter 2
Search

SLC5A2

0.65	Sodium/nucleoside cotransporter

0.56	GO:1904659	glucose transmembrane transport
0.49	GO:0006814	sodium ion transport
0.44	GO:0001951	intestinal D-glucose absorption
0.36	GO:0001656	metanephros development
0.33	GO:0006730	one-carbon metabolic process
0.33	GO:0005975	carbohydrate metabolic process

0.61	GO:0005412	glucose:sodium symporter activity
0.34	GO:0005515	protein binding
0.34	GO:0004089	carbonate dehydratase activity
0.33	GO:0008270	zinc ion binding

0.46	GO:0005887	integral component of plasma membrane
0.38	GO:0070062	extracellular exosome
0.38	GO:0005903	brush border
0.37	GO:0098590	plasma membrane region
0.37	GO:0045177	apical part of cell
0.36	GO:0120038	plasma membrane bounded cell projection part
0.35	GO:0005911	cell-cell junction

0.34

GO:0004089

sp|P31641|SC6A6_HUMAN
Sodium- and chloride-dependent taurine transporter
Search

SLC6A6

0.46	Sodium- and chloride-dependent taurine transporter

0.82	GO:0015734	taurine transport
0.76	GO:0006836	neurotransmitter transport
0.54	GO:0055085	transmembrane transport
0.42	GO:0006865	amino acid transport
0.33	GO:0006520	cellular amino acid metabolic process

0.86	GO:0005369	taurine:sodium symporter activity
0.79	GO:0005328	neurotransmitter:sodium symporter activity
0.35	GO:0043210	alkanesulfonate binding
0.34	GO:0015171	amino acid transmembrane transporter activity

0.66

GO:0005887

integral component of plasma membrane

sp|P31644|GBRA5_HUMAN
Gamma-aminobutyric acid receptor subunit alpha-5
Search

GABRA5

0.93	Gamma-aminobutyric acid receptor subunit alpha-5

0.85	GO:0007214	gamma-aminobutyric acid signaling pathway
0.76	GO:0006821	chloride transport
0.60	GO:0034220	ion transmembrane transport
0.53	GO:0060384	innervation
0.53	GO:0001662	behavioral fear response
0.53	GO:0090102	cochlea development
0.52	GO:0060119	inner ear receptor cell development
0.52	GO:0008306	associative learning
0.51	GO:0043524	negative regulation of neuron apoptotic process
0.50	GO:0007605	sensory perception of sound

0.84	GO:0004890	GABA-A receptor activity
0.76	GO:0005230	extracellular ligand-gated ion channel activity
0.41	GO:0005254	chloride channel activity
0.39	GO:0050811	GABA receptor binding
0.38	GO:0008503	benzodiazepine receptor activity
0.38	GO:0099095	ligand-gated anion channel activity
0.37	GO:0022835	transmitter-gated channel activity
0.34	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

0.56	GO:0030425	dendrite
0.56	GO:0044297	cell body
0.56	GO:0005886	plasma membrane
0.53	GO:1902711	GABA-A receptor complex
0.50	GO:0060077	inhibitory synapse
0.49	GO:0098794	postsynapse
0.47	GO:0030424	axon
0.47	GO:0005654	nucleoplasm
0.46	GO:0005829	cytosol
0.42	GO:0034707	chloride channel complex

sp|P31645|SC6A4_HUMAN
Sodium-dependent serotonin transporter
Search

SLC6A4

0.48	Sodium-dependent serotonin transporter

0.82	GO:0006837	serotonin transport
0.67	GO:0090067	regulation of thalamus size
0.63	GO:0098810	neurotransmitter reuptake
0.57	GO:0046621	negative regulation of organ growth
0.57	GO:0035176	social behavior
0.57	GO:0048854	brain morphogenesis
0.55	GO:0055085	transmembrane transport
0.53	GO:0045787	positive regulation of cell cycle
0.52	GO:0090494	dopamine uptake
0.51	GO:0001963	synaptic transmission, dopaminergic

0.83	GO:0015222	serotonin transmembrane transporter activity
0.79	GO:0005328	neurotransmitter:sodium symporter activity
0.59	GO:0050998	nitric-oxide synthase binding
0.54	GO:0017137	Rab GTPase binding
0.52	GO:0005329	dopamine transmembrane transporter activity
0.40	GO:0019811	cocaine binding
0.40	GO:0051015	actin filament binding
0.39	GO:0017075	syntaxin-1 binding
0.38	GO:0017022	myosin binding
0.37	GO:0051378	serotonin binding

0.61	GO:0005887	integral component of plasma membrane
0.56	GO:0098793	presynapse
0.54	GO:0045121	membrane raft
0.49	GO:0005829	cytosol
0.49	GO:0012505	endomembrane system
0.47	GO:0043005	neuron projection
0.39	GO:0044433	cytoplasmic vesicle part
0.39	GO:0098588	bounding membrane of organelle
0.36	GO:0016324	apical plasma membrane

sp|P31689|DNJA1_HUMAN
DnaJ homolog subfamily A member 1
Search

DNAJA1

0.81	DnaJ like protein subfamily A member 1

0.69	GO:0006457	protein folding
0.67	GO:0009408	response to heat
0.57	GO:1905259	negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
0.56	GO:0043508	negative regulation of JUN kinase activity
0.56	GO:1903748	negative regulation of establishment of protein localization to mitochondrion
0.53	GO:0031397	negative regulation of protein ubiquitination
0.52	GO:0032781	positive regulation of ATPase activity
0.51	GO:0043065	positive regulation of apoptotic process
0.51	GO:0070585	protein localization to mitochondrion
0.51	GO:0051223	regulation of protein transport

0.76	GO:0031072	heat shock protein binding
0.71	GO:0051082	unfolded protein binding
0.56	GO:0055131	C3HC4-type RING finger domain binding
0.56	GO:0030957	Tat protein binding
0.54	GO:0050750	low-density lipoprotein particle receptor binding
0.53	GO:0046872	metal ion binding
0.52	GO:0001671	ATPase activator activity
0.51	GO:0001664	G-protein coupled receptor binding
0.50	GO:0031625	ubiquitin protein ligase binding
0.50	GO:0051087	chaperone binding

0.49	GO:0005829	cytosol
0.49	GO:0000151	ubiquitin ligase complex
0.47	GO:0015630	microtubule cytoskeleton
0.40	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0005783	endoplasmic reticulum
0.37	GO:0005634	nucleus
0.37	GO:0005739	mitochondrion
0.36	GO:0070062	extracellular exosome
0.34	GO:0098562	cytoplasmic side of membrane
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network

sp|P31749|AKT1_HUMAN
RAC-alpha serine/threonine-protein kinase
Search

AKT1

0.41	RAC-alpha serine/threonine-protein kinase

0.63	GO:0006468	protein phosphorylation
0.62	GO:1990418	response to insulin-like growth factor stimulus
0.59	GO:0060416	response to growth hormone
0.56	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport
0.55	GO:1903721	positive regulation of I-kappaB phosphorylation
0.55	GO:0090201	negative regulation of release of cytochrome c from mitochondria
0.55	GO:0010918	positive regulation of mitochondrial membrane potential
0.55	GO:0006924	activation-induced cell death of T cells
0.55	GO:0032287	peripheral nervous system myelin maintenance
0.55	GO:0031999	negative regulation of fatty acid beta-oxidation

0.70	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030235	nitric-oxide synthase regulator activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.54	GO:0071889	14-3-3 protein binding
0.54	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
0.53	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.51	GO:0004712	protein serine/threonine/tyrosine kinase activity

0.52	GO:0036064	ciliary basal body
0.49	GO:0005819	spindle
0.49	GO:0005911	cell-cell junction
0.47	GO:0031982	vesicle
0.46	GO:0005829	cytosol
0.44	GO:0005634	nucleus
0.43	GO:0005739	mitochondrion
0.43	GO:0043234	protein complex
0.41	GO:0005886	plasma membrane
0.36	GO:0001726	ruffle

0.70

GO:0004674

sp|P31751|AKT2_HUMAN
RAC-beta serine/threonine-protein kinase
Search

AKT2

0.54	RAC-beta serine/threonine-protein kinase A

0.63	GO:0006468	protein phosphorylation
0.58	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport
0.57	GO:0046326	positive regulation of glucose import
0.57	GO:0010918	positive regulation of mitochondrial membrane potential
0.57	GO:0043434	response to peptide hormone
0.56	GO:0045725	positive regulation of glycogen biosynthetic process
0.56	GO:0031998	regulation of fatty acid beta-oxidation
0.56	GO:0032287	peripheral nervous system myelin maintenance
0.56	GO:0097473	retinal rod cell apoptotic process
0.55	GO:0071486	cellular response to high light intensity

0.70	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0032555	purine ribonucleotide binding
0.42	GO:0030235	nitric-oxide synthase regulator activity
0.42	GO:0071889	14-3-3 protein binding
0.41	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
0.41	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.40	GO:0019901	protein kinase binding

0.53	GO:0032587	ruffle membrane
0.49	GO:0005938	cell cortex
0.47	GO:0005829	cytosol
0.45	GO:0005634	nucleus
0.43	GO:0043234	protein complex
0.40	GO:0036064	ciliary basal body
0.40	GO:0031982	vesicle
0.39	GO:0005819	spindle
0.39	GO:0005911	cell-cell junction
0.36	GO:0005739	mitochondrion

0.70

GO:0004674

sp|P31785|IL2RG_HUMAN
Cytokine receptor common subunit gamma
Search

IL2RG

0.93	Common cytokine receptor gamma chain variant b

0.78	GO:0019221	cytokine-mediated signaling pathway
0.47	GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
0.47	GO:0033089	positive regulation of T cell differentiation in thymus
0.46	GO:0045579	positive regulation of B cell differentiation
0.42	GO:0010628	positive regulation of gene expression
0.40	GO:0098756	response to interleukin-21
0.40	GO:0071355	cellular response to interleukin-9
0.39	GO:0098761	cellular response to interleukin-7
0.39	GO:0071350	cellular response to interleukin-15
0.39	GO:0071352	cellular response to interleukin-2

0.80	GO:0004896	cytokine receptor activity
0.49	GO:0019976	interleukin-2 binding
0.37	GO:0005088	Ras guanyl-nucleotide exchange factor activity

0.46	GO:0009897	external side of plasma membrane
0.37	GO:0005768	endosome
0.36	GO:0005829	cytosol
0.35	GO:0005887	integral component of plasma membrane

sp|P31930|QCR1_HUMAN
Cytochrome b-c1 complex subunit 1, mitochondrial
Search

UQCRC1

0.90	Mitochondrial ubiquinol-cytochrome-c reductase complex core protein i

0.62	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c
0.49	GO:0016485	protein processing
0.44	GO:0009060	aerobic respiration

0.63	GO:0031625	ubiquitin protein ligase binding
0.54	GO:0046872	metal ion binding
0.47	GO:0004222	metalloendopeptidase activity
0.36	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
0.34	GO:0009055	electron transfer activity

0.65	GO:0043209	myelin sheath
0.56	GO:0005829	cytosol
0.53	GO:0031966	mitochondrial membrane
0.53	GO:0019866	organelle inner membrane
0.49	GO:0098798	mitochondrial protein complex
0.48	GO:0045275	respiratory chain complex III
0.30	GO:0016021	integral component of membrane

0.47

GO:0004222

sp|P31937|3HIDH_HUMAN
3-hydroxyisobutyrate dehydrogenase, mitochondrial
Search

HIBADH

0.54	3-hydroxyisobutyrate dehydrogenase, mitochondrial

0.78	GO:0006574	valine catabolic process
0.53	GO:0055114	oxidation-reduction process

0.81	GO:0008442	3-hydroxyisobutyrate dehydrogenase activity
0.76	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
0.68	GO:0051287	NAD binding

0.43	GO:0005739	mitochondrion
0.33	GO:0070013	intracellular organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.81

EC:1.1.1.31

GO:0008442

sp|P31939|PUR9_HUMAN
Bifunctional purine biosynthesis protein PURH
Search

ATIC

0.81	Aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase

0.66

GO:0006164

purine nucleotide biosynthetic process

0.79	GO:0004643	phosphoribosylaminoimidazolecarboxamide formyltransferase activity
0.79	GO:0003937	IMP cyclohydrolase activity
0.66	GO:0045296	cadherin binding
0.62	GO:0042803	protein homodimerization activity

0.57	GO:0005829	cytosol
0.51	GO:0005739	mitochondrion
0.48	GO:0005886	plasma membrane

0.79

EC:2.1.2.3

GO:0004643

sp|P31941|ABC3A_HUMAN
DNA dC->dU-editing enzyme APOBEC-3A
Search

APOBEC3A

0.94	Apolipoprotein B mRNA editing enzyme catalytic subunit 3A

0.46	GO:0070383	DNA cytosine deamination
0.46	GO:0010529	negative regulation of transposition
0.43	GO:0045087	innate immune response
0.43	GO:0009972	cytidine deamination
0.43	GO:0051607	defense response to virus
0.40	GO:0045071	negative regulation of viral genome replication
0.38	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate
0.37	GO:0044356	clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine
0.36	GO:0002230	positive regulation of defense response to virus by host
0.36	GO:0080111	DNA demethylation

0.71	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
0.63	GO:0008270	zinc ion binding
0.42	GO:0019239	deaminase activity
0.35	GO:0005515	protein binding
0.34	GO:0003723	RNA binding

0.42	GO:0000932	P-body
0.39	GO:0005634	nucleus

0.71

EC:3.5.4

GO:0016814

sp|P31942|HNRH3_HUMAN
Heterogeneous nuclear ribonucleoprotein H3
Search

HNRNPH3

0.97	Heterogeneous nuclear ribonucleoprotein H3

0.54	GO:0030855	epithelial cell differentiation
0.34	GO:0000398	mRNA splicing, via spliceosome
0.32	GO:0009058	biosynthetic process

0.57	GO:0003723	RNA binding
0.33	GO:0005515	protein binding
0.30	GO:0003824	catalytic activity

0.62	GO:0019013	viral nucleocapsid
0.54	GO:1990904	ribonucleoprotein complex
0.50	GO:0005654	nucleoplasm

sp|P31943|HNRH1_HUMAN
Heterogeneous nuclear ribonucleoprotein H
Search

HNRNPH1

0.88	Heterogeneous nuclear ribonucleoprotein H

0.52	GO:0043484	regulation of RNA splicing
0.37	GO:0008380	RNA splicing
0.37	GO:0006397	mRNA processing
0.36	GO:0071495	cellular response to endogenous stimulus
0.36	GO:0071310	cellular response to organic substance
0.35	GO:0071774	response to fibroblast growth factor
0.35	GO:1901652	response to peptide
0.35	GO:1901699	cellular response to nitrogen compound
0.35	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.35	GO:1901701	cellular response to oxygen-containing compound

0.59	GO:0003723	RNA binding
0.36	GO:0005515	protein binding

0.58	GO:0019013	viral nucleocapsid
0.55	GO:0030529	intracellular ribonucleoprotein complex
0.49	GO:0005654	nucleoplasm
0.48	GO:0005829	cytosol
0.43	GO:1902494	catalytic complex
0.30	GO:0016020	membrane

sp|P31944|CASPE_HUMAN
Caspase-14
Search

CASP14

0.97	Caspase 14, apoptosis-related cysteine peptidase

0.76	GO:0070268	cornification
0.61	GO:0006508	proteolysis
0.56	GO:0097194	execution phase of apoptosis
0.49	GO:0042981	regulation of apoptotic process
0.40	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway
0.40	GO:0050718	positive regulation of interleukin-1 beta secretion
0.39	GO:0051882	mitochondrial depolarization
0.39	GO:0050727	regulation of inflammatory response
0.39	GO:0050717	positive regulation of interleukin-1 alpha secretion
0.39	GO:0071260	cellular response to mechanical stimulus

0.75	GO:0004197	cysteine-type endopeptidase activity
0.40	GO:0050700	CARD domain binding
0.38	GO:0019900	kinase binding
0.37	GO:0042802	identical protein binding
0.33	GO:0097110	scaffold protein binding
0.32	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0008144	drug binding

0.54	GO:0005829	cytosol
0.49	GO:0005634	nucleus
0.49	GO:0005739	mitochondrion
0.44	GO:0045095	keratin filament
0.40	GO:0097179	protease inhibitor complex
0.39	GO:0005576	extracellular region
0.37	GO:0031982	vesicle
0.33	GO:0043005	neuron projection
0.32	GO:0070013	intracellular organelle lumen

0.75

EC:3.4.22

GO:0004197

sp|P31946|1433B_HUMAN
14-3-3 protein beta/alpha
Search

YWHAB

0.96	14-3-3 protein beta/alpha

0.51	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
0.50	GO:0051220	cytoplasmic sequestering of protein
0.48	GO:0035308	negative regulation of protein dephosphorylation
0.46	GO:0006605	protein targeting
0.45	GO:0043085	positive regulation of catalytic activity
0.41	GO:0090168	Golgi reassembly
0.40	GO:0051683	establishment of Golgi localization
0.39	GO:0051291	protein heterooligomerization
0.39	GO:0010941	regulation of cell death
0.37	GO:0045892	negative regulation of transcription, DNA-templated

0.73	GO:0019904	protein domain specific binding
0.50	GO:0050815	phosphoserine residue binding
0.49	GO:0045296	cadherin binding
0.49	GO:0042826	histone deacetylase binding
0.47	GO:0042802	identical protein binding
0.39	GO:0044325	ion channel binding
0.38	GO:0031625	ubiquitin protein ligase binding
0.38	GO:0008022	protein C-terminus binding
0.38	GO:0019901	protein kinase binding
0.38	GO:0003714	transcription corepressor activity

0.48	GO:0048471	perinuclear region of cytoplasm
0.45	GO:0042470	melanosome
0.43	GO:0005829	cytosol
0.38	GO:0017053	transcriptional repressor complex
0.38	GO:0005925	focal adhesion
0.38	GO:0070062	extracellular exosome
0.37	GO:0005634	nucleus
0.37	GO:0030659	cytoplasmic vesicle membrane
0.36	GO:0005739	mitochondrion
0.35	GO:0043234	protein complex

sp|P31947|1433S_HUMAN
14-3-3 protein sigma
Search

SFN

0.96	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like

0.60	GO:0010482	regulation of epidermal cell division
0.58	GO:0001836	release of cytochrome c from mitochondria
0.58	GO:0010839	negative regulation of keratinocyte proliferation
0.58	GO:0045606	positive regulation of epidermal cell differentiation
0.58	GO:0003334	keratinocyte development
0.58	GO:0061436	establishment of skin barrier
0.57	GO:0031424	keratinization
0.56	GO:0046827	positive regulation of protein export from nucleus
0.56	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
0.56	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

0.77	GO:0019904	protein domain specific binding
0.55	GO:0051219	phosphoprotein binding
0.54	GO:0045296	cadherin binding
0.52	GO:0019901	protein kinase binding
0.51	GO:0042802	identical protein binding
0.36	GO:0008426	protein kinase C inhibitor activity
0.35	GO:0004497	monooxygenase activity
0.34	GO:0004584	dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity
0.34	GO:0047485	protein N-terminus binding
0.34	GO:0019706	protein-cysteine S-palmitoyltransferase activity

0.48	GO:0005829	cytosol
0.45	GO:0005634	nucleus
0.37	GO:0005576	extracellular region
0.36	GO:0031982	vesicle
0.34	GO:0031090	organelle membrane
0.34	GO:0044446	intracellular organelle part
0.33	GO:0005739	mitochondrion
0.33	GO:0032991	macromolecular complex
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

0.34

EC:2.4.1.130

GO:0004584

sp|P31948|STIP1_HUMAN
Stress-induced-phosphoprotein 1
Search

STIP1

0.83	Stress-induced-phosphoprotein 1

0.43	GO:0007229	integrin-mediated signaling pathway
0.34	GO:0006412	translation

0.47	GO:0008483	transaminase activity
0.43	GO:0031072	heat shock protein binding
0.35	GO:0003735	structural constituent of ribosome
0.34	GO:0003723	RNA binding
0.30	GO:0008022	protein C-terminus binding
0.30	GO:0051087	chaperone binding

0.68	GO:0043209	myelin sheath
0.53	GO:0043234	protein complex
0.38	GO:0005634	nucleus
0.36	GO:0005737	cytoplasm
0.34	GO:0030529	intracellular ribonucleoprotein complex
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane
0.30	GO:0012505	endomembrane system

0.47

EC:2.6.1

GO:0008483

sp|P31949|S10AB_HUMAN
Protein S100-A11
Search

S100A11

0.80	S100 calcium binding protein A11

0.76	GO:0042127	regulation of cell proliferation
0.49	GO:0098609	cell-cell adhesion
0.36	GO:0007283	spermatogenesis
0.36	GO:0043312	neutrophil degranulation
0.35	GO:0008156	negative regulation of DNA replication
0.34	GO:0051013	microtubule severing
0.33	GO:0007165	signal transduction
0.33	GO:0051301	cell division
0.33	GO:0007049	cell cycle

0.85	GO:0048306	calcium-dependent protein binding
0.70	GO:0005509	calcium ion binding
0.53	GO:0098641	cadherin binding involved in cell-cell adhesion
0.53	GO:0044548	S100 protein binding
0.48	GO:0042803	protein homodimerization activity
0.35	GO:0008568	microtubule-severing ATPase activity
0.34	GO:0008017	microtubule binding
0.34	GO:0046914	transition metal ion binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.51	GO:0005913	cell-cell adherens junction
0.51	GO:0001726	ruffle
0.44	GO:0005576	extracellular region
0.43	GO:0005634	nucleus
0.38	GO:0005737	cytoplasm
0.36	GO:0031983	vesicle lumen
0.34	GO:0097708	intracellular vesicle
0.34	GO:0030496	midbody
0.34	GO:0000922	spindle pole
0.34	GO:0005813	centrosome

0.35

EC:3.6.4.3

GO:0008568

sp|P31994|FCG2B_HUMAN
Low affinity immunoglobulin gamma Fc region receptor II-b
Search

FCGR2A

0.97	Low affinity immunoglobulin gamma Fc region receptor II-b

0.42	GO:0038094	Fc-gamma receptor signaling pathway
0.42	GO:0001810	regulation of type I hypersensitivity
0.41	GO:0002274	myeloid leukocyte activation
0.41	GO:0002443	leukocyte mediated immunity
0.41	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
0.41	GO:0002431	Fc receptor mediated stimulatory signaling pathway
0.40	GO:0002478	antigen processing and presentation of exogenous peptide antigen
0.40	GO:0050766	positive regulation of phagocytosis
0.40	GO:0002884	negative regulation of hypersensitivity
0.40	GO:0006911	phagocytosis, engulfment

0.46	GO:0019864	IgG binding
0.42	GO:0019770	IgG receptor activity
0.39	GO:0001540	amyloid-beta binding
0.34	GO:0034987	immunoglobulin receptor binding
0.34	GO:0005057	signal transducer activity, downstream of receptor
0.34	GO:0019767	IgE receptor activity

0.39	GO:0009897	external side of plasma membrane
0.38	GO:0043197	dendritic spine
0.38	GO:0044297	cell body
0.36	GO:0070062	extracellular exosome
0.36	GO:0030667	secretory granule membrane
0.36	GO:0005887	integral component of plasma membrane
0.34	GO:0055037	recycling endosome
0.34	GO:0098857	membrane microdomain
0.33	GO:0005856	cytoskeleton
0.33	GO:0031225	anchored component of membrane

sp|P31995|FCG2C_HUMAN
Low affinity immunoglobulin gamma Fc region receptor II-c
Search

FCGR2A

0.97	Low affinity immunoglobulin gamma Fc region receptor II-c

0.42	GO:0038094	Fc-gamma receptor signaling pathway
0.41	GO:0002274	myeloid leukocyte activation
0.41	GO:0001810	regulation of type I hypersensitivity
0.41	GO:0002443	leukocyte mediated immunity
0.40	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
0.40	GO:0002431	Fc receptor mediated stimulatory signaling pathway
0.40	GO:0006955	immune response
0.40	GO:0002478	antigen processing and presentation of exogenous peptide antigen
0.39	GO:0050766	positive regulation of phagocytosis
0.39	GO:0006911	phagocytosis, engulfment

0.46	GO:0019864	IgG binding
0.41	GO:0019770	IgG receptor activity
0.38	GO:0001540	amyloid-beta binding
0.34	GO:0034987	immunoglobulin receptor binding
0.34	GO:0019767	IgE receptor activity
0.34	GO:0005057	signal transducer activity, downstream of receptor

0.39	GO:0009897	external side of plasma membrane
0.38	GO:0043197	dendritic spine
0.37	GO:0044297	cell body
0.37	GO:0070062	extracellular exosome
0.36	GO:0030667	secretory granule membrane
0.35	GO:0005887	integral component of plasma membrane
0.34	GO:0055037	recycling endosome
0.34	GO:0098857	membrane microdomain
0.33	GO:0031225	anchored component of membrane
0.33	GO:0005856	cytoskeleton

sp|P31997|CEAM8_HUMAN
Carcinoembryonic antigen-related cell adhesion molecule 8
Search

0.78	Carcinoembryonic antigen-related cell adhesion molecule 8

0.53	GO:0016477	cell migration
0.52	GO:0043312	neutrophil degranulation
0.52	GO:0043317	regulation of cytotoxic T cell degranulation
0.51	GO:0002859	negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
0.51	GO:0030334	regulation of cell migration
0.50	GO:0001915	negative regulation of T cell mediated cytotoxicity
0.50	GO:0043301	negative regulation of leukocyte degranulation
0.49	GO:0050860	negative regulation of T cell receptor signaling pathway
0.49	GO:0042127	regulation of cell proliferation
0.48	GO:0090505	epiboly involved in wound healing

0.51	GO:0031005	filamin binding
0.50	GO:1990782	protein tyrosine kinase binding
0.49	GO:0019903	protein phosphatase binding
0.48	GO:0042803	protein homodimerization activity
0.46	GO:0003779	actin binding
0.45	GO:0015125	bile acid transmembrane transporter activity
0.42	GO:0005516	calmodulin binding
0.42	GO:0034235	GPI anchor binding
0.41	GO:0005130	granulocyte colony-stimulating factor receptor binding
0.40	GO:0046790	virion binding

0.59	GO:0005615	extracellular space
0.51	GO:0042101	T cell receptor complex
0.51	GO:0030667	secretory granule membrane
0.49	GO:0042581	specific granule
0.48	GO:0009986	cell surface
0.48	GO:1903561	extracellular vesicle
0.48	GO:0070820	tertiary granule
0.48	GO:0005766	primary lysosome
0.48	GO:0031225	anchored component of membrane
0.46	GO:0005911	cell-cell junction

sp|P32004|L1CAM_HUMAN
Neural cell adhesion molecule L1
Search

L1CAM

0.94	Neural cell adhesion molecule L1

0.56	GO:0007160	cell-matrix adhesion
0.56	GO:0050808	synapse organization
0.56	GO:0007411	axon guidance
0.54	GO:0016477	cell migration
0.42	GO:0045773	positive regulation of axon extension
0.39	GO:0033631	cell-cell adhesion mediated by integrin
0.39	GO:0007159	leukocyte cell-cell adhesion
0.39	GO:0050850	positive regulation of calcium-mediated signaling
0.39	GO:0034109	homotypic cell-cell adhesion
0.39	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

0.53	GO:0019904	protein domain specific binding
0.39	GO:0033691	sialic acid binding
0.38	GO:0043621	protein self-association
0.38	GO:0005178	integrin binding
0.37	GO:0042802	identical protein binding
0.36	GO:0030506	ankyrin binding
0.35	GO:0086080	protein binding involved in heterotypic cell-cell adhesion
0.33	GO:0030247	polysaccharide binding
0.33	GO:0046982	protein heterodimerization activity

0.56	GO:0030424	axon
0.56	GO:0043025	neuronal cell body
0.53	GO:0009986	cell surface
0.52	GO:0031012	extracellular matrix
0.43	GO:0005886	plasma membrane
0.42	GO:0030426	growth cone
0.38	GO:0043679	axon terminus
0.38	GO:0005925	focal adhesion
0.38	GO:0030425	dendrite
0.37	GO:0098552	side of membrane

sp|P32019|I5P2_HUMAN
Type II inositol 1,4,5-trisphosphate 5-phosphatase
Search

INPP5B

0.96	Inositol polyphosphate-5-phosphatase B

0.79	GO:0046856	phosphatidylinositol dephosphorylation
0.59	GO:0007165	signal transduction
0.56	GO:0030317	flagellated sperm motility
0.56	GO:0070613	regulation of protein processing
0.54	GO:0007283	spermatogenesis
0.54	GO:0001701	in utero embryonic development
0.45	GO:0039023	pronephric duct morphogenesis
0.44	GO:0071871	response to epinephrine
0.44	GO:0070121	Kupffer's vesicle development
0.44	GO:0032402	melanosome transport

0.77	GO:0052745	inositol phosphate phosphatase activity
0.59	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
0.38	GO:0005096	GTPase activator activity
0.38	GO:0048365	Rac GTPase binding
0.35	GO:0046872	metal ion binding
0.33	GO:0003676	nucleic acid binding

0.49	GO:0005829	cytosol
0.40	GO:0005769	early endosome
0.38	GO:0030670	phagocytic vesicle membrane
0.38	GO:0001750	photoreceptor outer segment
0.38	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.37	GO:0005794	Golgi apparatus
0.37	GO:0030136	clathrin-coated vesicle
0.37	GO:0010008	endosome membrane
0.36	GO:0005634	nucleus
0.36	GO:0031984	organelle subcompartment

0.77	EC:3.1.3	GO:0052745
0.59	KEGG:R04404	GO:0004439

sp|P32119|PRDX2_HUMAN
Peroxiredoxin-2
Search

PRDX2

0.42	Natural killer cell enhancement factor

0.69	GO:0098869	cellular oxidant detoxification
0.68	GO:0045454	cell redox homeostasis
0.53	GO:0055114	oxidation-reduction process
0.49	GO:0071450	cellular response to oxygen radical
0.49	GO:0000303	response to superoxide
0.49	GO:0006801	superoxide metabolic process
0.47	GO:0042981	regulation of apoptotic process
0.41	GO:0042744	hydrogen peroxide catabolic process
0.41	GO:0046649	lymphocyte activation
0.40	GO:0008283	cell proliferation

0.73	GO:0051920	peroxiredoxin activity
0.51	GO:0004601	peroxidase activity
0.38	GO:0045296	cadherin binding
0.37	GO:0042802	identical protein binding
0.35	GO:0008430	selenium binding
0.34	GO:0000033	alpha-1,3-mannosyltransferase activity
0.33	GO:0003677	DNA binding
0.32	GO:0016829	lyase activity

0.41	GO:0043209	myelin sheath
0.37	GO:0043227	membrane-bounded organelle
0.36	GO:0005615	extracellular space
0.36	GO:0044444	cytoplasmic part
0.36	GO:0043229	intracellular organelle
0.36	GO:0043230	extracellular organelle
0.34	GO:0012505	endomembrane system
0.30	GO:0016021	integral component of membrane

0.73	EC:1.11.1.15	GO:0051920
0.51	KEGG:R03532	GO:0004601

sp|P32121|ARRB2_HUMAN
Beta-arrestin-2
Search

ARRB2

0.96	Beta arrestin 2 variant 4

0.61	GO:0007165	signal transduction
0.53	GO:0043393	regulation of protein binding
0.53	GO:0002031	G-protein coupled receptor internalization
0.53	GO:0032226	positive regulation of synaptic transmission, dopaminergic
0.53	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity
0.52	GO:0002092	positive regulation of receptor internalization
0.52	GO:0032691	negative regulation of interleukin-1 beta production
0.52	GO:0032695	negative regulation of interleukin-12 production
0.52	GO:2000727	positive regulation of cardiac muscle cell differentiation
0.52	GO:0034122	negative regulation of toll-like receptor signaling pathway

0.53	GO:0031701	angiotensin receptor binding
0.53	GO:0043422	protein kinase B binding
0.49	GO:0032947	protein complex scaffold activity
0.48	GO:0031625	ubiquitin protein ligase binding
0.41	GO:0031859	platelet activating factor receptor binding
0.41	GO:0031691	alpha-1A adrenergic receptor binding
0.41	GO:0031692	alpha-1B adrenergic receptor binding
0.41	GO:0031762	follicle-stimulating hormone receptor binding
0.41	GO:0031826	type 2A serotonin receptor binding
0.40	GO:0031748	D1 dopamine receptor binding

0.49	GO:0030139	endocytic vesicle
0.42	GO:0005634	nucleus
0.40	GO:0005886	plasma membrane
0.39	GO:0005905	clathrin-coated pit
0.39	GO:0043197	dendritic spine
0.39	GO:0014069	postsynaptic density
0.35	GO:0005829	cytosol

sp|P32189|GLPK_HUMAN
Glycerol kinase
Search

0.43	Glycerol kinase 3 pseudogene

0.73	GO:0006072	glycerol-3-phosphate metabolic process
0.59	GO:0005975	carbohydrate metabolic process
0.57	GO:0016310	phosphorylation
0.47	GO:0006641	triglyceride metabolic process
0.46	GO:0019751	polyol metabolic process
0.42	GO:0046164	alcohol catabolic process
0.41	GO:1901137	carbohydrate derivative biosynthetic process
0.41	GO:0090407	organophosphate biosynthetic process
0.40	GO:0019217	regulation of fatty acid metabolic process
0.40	GO:0042593	glucose homeostasis

0.77	GO:0004370	glycerol kinase activity
0.37	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0042393	histone binding
0.33	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

0.44	GO:0005739	mitochondrion
0.43	GO:0031968	organelle outer membrane
0.38	GO:0070062	extracellular exosome
0.38	GO:0005829	cytosol
0.36	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.77	EC:2.7.1.30	GO:0004370
0.77	KEGG:R00847	GO:0004370

sp|P32238|CCKAR_HUMAN
Cholecystokinin receptor type A
Search

CCKAR

0.96	Cholecystokinin receptor type A

0.79	GO:0038188	cholecystokinin signaling pathway
0.57	GO:0001764	neuron migration
0.55	GO:0030900	forebrain development
0.55	GO:0007409	axonogenesis
0.47	GO:0007631	feeding behavior
0.47	GO:0007586	digestion
0.46	GO:0046883	regulation of hormone secretion
0.46	GO:1901652	response to peptide
0.44	GO:0032870	cellular response to hormone stimulus
0.37	GO:0007584	response to nutrient

0.79	GO:0004951	cholecystokinin receptor activity
0.69	GO:0015054	gastrin receptor activity
0.45	GO:0042277	peptide binding

0.42	GO:0005887	integral component of plasma membrane
0.35	GO:0043195	terminal bouton
0.35	GO:0005764	lysosome
0.34	GO:0005768	endosome
0.34	GO:0005783	endoplasmic reticulum

sp|P32239|GASR_HUMAN
Gastrin/cholecystokinin type B receptor
Search

CCKBR

0.95	Cholecystokinin B receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.54	GO:0001696	gastric acid secretion
0.53	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.52	GO:0008284	positive regulation of cell proliferation
0.52	GO:0048565	digestive tract development
0.51	GO:0048732	gland development
0.37	GO:0007631	feeding behavior
0.36	GO:0043551	regulation of phosphatidylinositol 3-kinase activity
0.35	GO:0001764	neuron migration
0.35	GO:0008283	cell proliferation

0.85	GO:0015054	gastrin receptor activity
0.58	GO:0031741	type B gastrin/cholecystokinin receptor binding
0.55	GO:0004951	cholecystokinin receptor activity
0.36	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity
0.35	GO:0004435	phosphatidylinositol phospholipase C activity
0.33	GO:0042277	peptide binding
0.33	GO:0005216	ion channel activity

0.36	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.35	EC:3.1.4.11	GO:0004435
0.35	KEGG:R03435	GO:0004435

sp|P32241|VIPR1_HUMAN
Vasoactive intestinal polypeptide receptor 1
Search

VIPR1

0.94	Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide receptor

0.69	GO:0007166	cell surface receptor signaling pathway
0.69	GO:0007186	G-protein coupled receptor signaling pathway
0.36	GO:0007586	digestion
0.35	GO:0006936	muscle contraction
0.35	GO:0008284	positive regulation of cell proliferation
0.35	GO:0098916	anterograde trans-synaptic signaling
0.35	GO:0002121	inter-male aggressive behavior
0.35	GO:0006955	immune response

0.85	GO:0004999	vasoactive intestinal polypeptide receptor activity
0.34	GO:0005515	protein binding

0.51	GO:0005886	plasma membrane
0.51	GO:0043235	receptor complex
0.30	GO:0031224	intrinsic component of membrane

sp|P32242|OTX1_HUMAN
Homeobox protein OTX1
Search

OTX1

0.96	Orthodenticle homeobox 1

0.74	GO:0048852	diencephalon morphogenesis
0.70	GO:0030901	midbrain development
0.69	GO:0042472	inner ear morphogenesis
0.69	GO:0022037	metencephalon development
0.67	GO:0009952	anterior/posterior pattern specification
0.64	GO:0006366	transcription by RNA polymerase II
0.63	GO:0045944	positive regulation of transcription by RNA polymerase II
0.46	GO:0071542	dopaminergic neuron differentiation
0.44	GO:0003406	retinal pigment epithelium development
0.44	GO:0007411	axon guidance

0.68	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.67	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.45	GO:0030426	growth cone
0.38	GO:0043234	protein complex

sp|P32243|OTX2_HUMAN
Homeobox protein OTX2
Search

OTX2

0.88	Orthodenticle homeobox 2

0.70	GO:0007275	multicellular organism development
0.61	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.61	GO:0000904	cell morphogenesis involved in differentiation
0.60	GO:0045944	positive regulation of transcription by RNA polymerase II
0.60	GO:0120036	plasma membrane bounded cell projection organization
0.59	GO:0006366	transcription by RNA polymerase II
0.56	GO:0006935	chemotaxis
0.55	GO:0006928	movement of cell or subcellular component
0.55	GO:0006461	protein complex assembly
0.45	GO:2000543	positive regulation of gastrulation

0.63	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.63	GO:0043565	sequence-specific DNA binding
0.61	GO:0001012	RNA polymerase II regulatory region DNA binding
0.57	GO:0003690	double-stranded DNA binding
0.35	GO:0005515	protein binding

0.65	GO:0030426	growth cone
0.61	GO:0005634	nucleus
0.49	GO:0043234	protein complex

sp|P32245|MC4R_HUMAN
Melanocortin receptor 4
Search

MC4R

0.94	Melanocortin 4 receptor variant

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.57	GO:0046852	positive regulation of bone remodeling
0.56	GO:0045124	regulation of bone resorption
0.54	GO:0019933	cAMP-mediated signaling
0.54	GO:0032846	positive regulation of homeostatic process
0.48	GO:0030073	insulin secretion
0.47	GO:0007631	feeding behavior
0.46	GO:0032868	response to insulin
0.38	GO:2000821	regulation of grooming behavior
0.38	GO:2000252	negative regulation of feeding behavior

0.84	GO:0004977	melanocortin receptor activity
0.57	GO:0042923	neuropeptide binding
0.52	GO:0031625	ubiquitin protein ligase binding
0.38	GO:0017046	peptide hormone binding

0.55	GO:0005886	plasma membrane
0.37	GO:0005622	intracellular
0.34	GO:0043227	membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

sp|P32246|CCR1_HUMAN
C-C chemokine receptor type 1
Search

0.97	C-C motif chemokine receptor 1

0.83	GO:0070098	chemokine-mediated signaling pathway
0.79	GO:0006954	inflammatory response
0.72	GO:0090026	positive regulation of monocyte chemotaxis
0.70	GO:0006935	chemotaxis
0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.67	GO:0006955	immune response
0.56	GO:0051094	positive regulation of developmental process
0.56	GO:0051240	positive regulation of multicellular organismal process
0.55	GO:2000026	regulation of multicellular organismal development
0.52	GO:0030279	negative regulation of ossification

0.85	GO:0016493	C-C chemokine receptor activity
0.65	GO:0019957	C-C chemokine binding
0.50	GO:0004435	phosphatidylinositol phospholipase C activity
0.37	GO:0031727	CCR2 chemokine receptor binding
0.36	GO:0003779	actin binding

0.52	GO:0009897	external side of plasma membrane
0.37	GO:0005768	endosome
0.36	GO:0043025	neuronal cell body
0.35	GO:0005887	integral component of plasma membrane
0.34	GO:0005615	extracellular space

0.50	EC:3.1.4.11	GO:0004435
0.50	KEGG:R03435	GO:0004435

sp|P32247|BRS3_HUMAN
Bombesin receptor subtype-3
Search

BRS3

0.94	Gastrin-releasing peptide receptor

0.79	GO:0031989	bombesin receptor signaling pathway
0.52	GO:0036343	psychomotor behavior
0.50	GO:0035176	social behavior
0.50	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
0.48	GO:0007218	neuropeptide signaling pathway
0.47	GO:0042127	regulation of cell proliferation
0.44	GO:0043207	response to external biotic stimulus
0.36	GO:0008343	adult feeding behavior
0.35	GO:0008217	regulation of blood pressure
0.34	GO:0006006	glucose metabolic process

0.79	GO:0004946	bombesin receptor activity
0.34	GO:0042923	neuropeptide binding
0.32	GO:0005515	protein binding
0.32	GO:0003723	RNA binding

0.44	GO:0005887	integral component of plasma membrane
0.40	GO:0005829	cytosol
0.38	GO:0043025	neuronal cell body
0.37	GO:0043005	neuron projection

sp|P32248|CCR7_HUMAN
C-C chemokine receptor type 7
Search

CCR7

0.97	C-C motif chemokine receptor 7

0.83	GO:0070098	chemokine-mediated signaling pathway
0.73	GO:0006954	inflammatory response
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.70	GO:0006935	chemotaxis
0.69	GO:0006955	immune response
0.64	GO:2000526	positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
0.64	GO:2000522	positive regulation of immunological synapse formation
0.64	GO:0072610	interleukin-12 secretion
0.63	GO:2000523	regulation of T cell costimulation
0.63	GO:0097029	mature conventional dendritic cell differentiation

0.84	GO:0004950	chemokine receptor activity
0.63	GO:0035757	chemokine (C-C motif) ligand 19 binding
0.63	GO:0035758	chemokine (C-C motif) ligand 21 binding
0.38	GO:0015026	coreceptor activity
0.35	GO:0019958	C-X-C chemokine binding
0.35	GO:0019960	C-X3-C chemokine binding
0.35	GO:0051916	granulocyte colony-stimulating factor binding
0.35	GO:0005044	scavenger receptor activity
0.34	GO:0048020	CCR chemokine receptor binding
0.33	GO:0008188	neuropeptide receptor activity

0.58	GO:0009897	external side of plasma membrane
0.46	GO:0005739	mitochondrion
0.39	GO:0097524	sperm plasma membrane
0.39	GO:0097225	sperm midpiece
0.39	GO:0097228	sperm principal piece
0.33	GO:0005887	integral component of plasma membrane
0.33	GO:0005654	nucleoplasm
0.32	GO:0043005	neuron projection

sp|P32249|GP183_HUMAN
G-protein coupled receptor 183
Search

GPR183

0.78	Epstein-Barr virus-induced G-protein coupled receptor 2

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.65	GO:2000458	regulation of astrocyte chemotaxis
0.65	GO:0036145	dendritic cell homeostasis
0.63	GO:0061470	T follicular helper cell differentiation
0.63	GO:0010818	T cell chemotaxis
0.62	GO:0002407	dendritic cell chemotaxis
0.62	GO:0002312	B cell activation involved in immune response
0.61	GO:0030890	positive regulation of B cell proliferation
0.61	GO:0002335	mature B cell differentiation
0.61	GO:0030316	osteoclast differentiation

0.72	GO:0004930	G-protein coupled receptor activity
0.65	GO:0008142	oxysterol binding
0.36	GO:0004896	cytokine receptor activity
0.36	GO:0001653	peptide receptor activity
0.34	GO:0035717	chemokine (C-C motif) ligand 7 binding
0.34	GO:0071791	chemokine (C-C motif) ligand 5 binding
0.33	GO:0004435	phosphatidylinositol phospholipase C activity

0.44	GO:0005886	plasma membrane
0.33	GO:0009986	cell surface
0.33	GO:0098552	side of membrane
0.30	GO:0016021	integral component of membrane

0.33	EC:3.1.4.11	GO:0004435
0.33	KEGG:R03435	GO:0004435

sp|P32297|ACHA3_HUMAN
Neuronal acetylcholine receptor subunit alpha-3
Search

CHRNA3

0.90	Cholinergic receptor nicotinic alpha 3 subunit

0.80	GO:0060079	excitatory postsynaptic potential
0.66	GO:0060084	synaptic transmission involved in micturition
0.64	GO:0035095	behavioral response to nicotine
0.60	GO:0034220	ion transmembrane transport
0.55	GO:0007399	nervous system development
0.41	GO:0006812	cation transport
0.38	GO:0007271	synaptic transmission, cholinergic

0.83	GO:0022848	acetylcholine-gated cation-selective channel activity
0.70	GO:0099600	transmembrane receptor activity
0.50	GO:0022850	serotonin-gated cation-selective channel activity
0.38	GO:0042166	acetylcholine binding
0.35	GO:0051537	2 iron, 2 sulfur cluster binding

0.79	GO:0045211	postsynaptic membrane
0.75	GO:0030054	cell junction
0.62	GO:0005892	acetylcholine-gated channel complex

sp|P32298|GRK4_HUMAN
G protein-coupled receptor kinase 4
Search

GRK4

0.70	G protein-coupled receptor kinase

0.63	GO:0006468	protein phosphorylation
0.60	GO:0007165	signal transduction
0.55	GO:0031623	receptor internalization
0.45	GO:0008284	positive regulation of cell proliferation
0.45	GO:0043066	negative regulation of apoptotic process
0.43	GO:0051726	regulation of cell cycle
0.41	GO:0045444	fat cell differentiation
0.40	GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
0.38	GO:0085033	positive regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
0.36	GO:0006915	apoptotic process

0.85	GO:0004703	G-protein coupled receptor kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0047696	beta-adrenergic receptor kinase activity
0.39	GO:0050254	rhodopsin kinase activity
0.36	GO:0008289	lipid binding
0.35	GO:0005080	protein kinase C binding

0.45	GO:0016607	nuclear speck
0.45	GO:0031965	nuclear membrane
0.43	GO:0005829	cytosol
0.38	GO:0071944	cell periphery
0.37	GO:0043025	neuronal cell body
0.37	GO:0030425	dendrite
0.37	GO:0099568	cytoplasmic region
0.35	GO:0001750	photoreceptor outer segment
0.35	GO:0070062	extracellular exosome
0.34	GO:0098588	bounding membrane of organelle

0.85

EC:2.7.11.16

GO:0004703

sp|P32302|CXCR5_HUMAN
C-X-C chemokine receptor type 5
Search

CXCR5

0.94	C-X-C motif chemokine receptor 5

0.81	GO:0070098	chemokine-mediated signaling pathway
0.78	GO:0048535	lymph node development
0.74	GO:0042113	B cell activation
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.69	GO:0006935	chemotaxis
0.69	GO:0006955	immune response
0.60	GO:0032467	positive regulation of cytokinesis
0.58	GO:0050900	leukocyte migration
0.51	GO:0006954	inflammatory response
0.43	GO:0002507	tolerance induction

0.82	GO:0004950	chemokine receptor activity
0.40	GO:0004982	N-formyl peptide receptor activity
0.39	GO:0019956	chemokine binding
0.35	GO:0004435	phosphatidylinositol phospholipase C activity
0.35	GO:0004875	complement receptor activity
0.34	GO:0004535	poly(A)-specific ribonuclease activity
0.33	GO:0005124	scavenger receptor binding
0.33	GO:0050786	RAGE receptor binding
0.33	GO:0015057	thrombin-activated receptor activity

0.59	GO:0009897	external side of plasma membrane
0.36	GO:0005887	integral component of plasma membrane
0.35	GO:0043025	neuronal cell body
0.33	GO:0101003	ficolin-1-rich granule membrane
0.33	GO:0035577	azurophil granule membrane
0.33	GO:0005768	endosome
0.33	GO:0005615	extracellular space

0.35	EC:3.1.4.11	GO:0004435
0.35	KEGG:R03435	GO:0004435

sp|P32314|FOXN2_HUMAN
Forkhead box protein N2
Search

FOXN2

0.93	Forkhead box protein N2

0.63	GO:0035914	skeletal muscle cell differentiation
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.49	GO:0051254	positive regulation of RNA metabolic process
0.48	GO:0010557	positive regulation of macromolecule biosynthetic process
0.48	GO:0031328	positive regulation of cellular biosynthetic process
0.44	GO:0007095	mitotic G2 DNA damage checkpoint
0.42	GO:0097094	craniofacial suture morphogenesis
0.40	GO:0051253	negative regulation of RNA metabolic process

0.64	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.43	GO:0008022	protein C-terminus binding

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P32320|CDD_HUMAN
Cytidine deaminase
Search

CDA

0.48	Cytidine deaminase

0.79	GO:0009972	cytidine deamination
0.55	GO:0045980	negative regulation of nucleotide metabolic process
0.54	GO:0051289	protein homotetramerization
0.54	GO:0030308	negative regulation of cell growth
0.36	GO:0019858	cytosine metabolic process
0.36	GO:0071217	cellular response to external biotic stimulus
0.36	GO:0043312	neutrophil degranulation
0.36	GO:0046898	response to cycloheximide
0.35	GO:0043097	pyrimidine nucleoside salvage
0.34	GO:0007166	cell surface receptor signaling pathway

0.79	GO:0004126	cytidine deaminase activity
0.62	GO:0008270	zinc ion binding
0.50	GO:0042803	protein homodimerization activity
0.46	GO:0001882	nucleoside binding

0.41	GO:0005829	cytosol
0.36	GO:1904724	tertiary granule lumen
0.36	GO:1904813	ficolin-1-rich granule lumen
0.36	GO:0034774	secretory granule lumen
0.34	GO:0005576	extracellular region

0.79

EC:3.5.4.5

GO:0004126

sp|P32321|DCTD_HUMAN
Deoxycytidylate deaminase
Search

DCTD

0.61	Deoxycytidylate deaminase

0.63	GO:0006220	pyrimidine nucleotide metabolic process
0.39	GO:0009176	pyrimidine deoxyribonucleoside monophosphate metabolic process
0.39	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process
0.39	GO:0046385	deoxyribose phosphate biosynthetic process
0.38	GO:0009394	2'-deoxyribonucleotide metabolic process
0.38	GO:0009263	deoxyribonucleotide biosynthetic process
0.38	GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process
0.37	GO:0072528	pyrimidine-containing compound biosynthetic process
0.37	GO:0015949	nucleobase-containing small molecule interconversion

0.74	GO:0004132	dCMP deaminase activity
0.62	GO:0008270	zinc ion binding
0.42	GO:0042802	identical protein binding
0.32	GO:0003676	nucleic acid binding

0.38	GO:0070062	extracellular exosome
0.35	GO:0005829	cytosol

0.74

EC:3.5.4.12

GO:0004132

sp|P32322|P5CR1_HUMAN
Pyrroline-5-carboxylate reductase 1, mitochondrial
Search

PYCR1

0.52	Pyrroline-5-carboxylate reductase

0.75	GO:0055129	L-proline biosynthetic process
0.52	GO:0055114	oxidation-reduction process
0.52	GO:1901032	negative regulation of response to reactive oxygen species
0.52	GO:2001039	negative regulation of cellular response to drug
0.51	GO:1903205	regulation of hydrogen peroxide-induced cell death
0.51	GO:1903202	negative regulation of oxidative stress-induced cell death
0.50	GO:0051881	regulation of mitochondrial membrane potential
0.50	GO:0034599	cellular response to oxidative stress
0.40	GO:0007420	brain development
0.32	GO:0006351	transcription, DNA-templated

0.78	GO:0004735	pyrroline-5-carboxylate reductase activity
0.46	GO:0042802	identical protein binding
0.33	GO:0003700	DNA binding transcription factor activity
0.32	GO:0003677	DNA binding

0.44	GO:0005739	mitochondrion
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.78

EC:1.5.1.2

GO:0004735

sp|P32418|NAC1_HUMAN
Sodium/calcium exchanger 1
Search

SLC8A1

0.82	Solute carrier family 8 sodium/calcium exchanger member 1 splicing variant 1.41

0.76	GO:0035725	sodium ion transmembrane transport
0.76	GO:0006816	calcium ion transport
0.67	GO:0098735	positive regulation of the force of heart contraction
0.66	GO:0006883	cellular sodium ion homeostasis
0.66	GO:0035994	response to muscle stretch
0.64	GO:0030501	positive regulation of bone mineralization
0.60	GO:0007154	cell communication
0.40	GO:0045214	sarcomere organization
0.39	GO:0006874	cellular calcium ion homeostasis

0.85	GO:0005432	calcium:sodium antiporter activity
0.66	GO:0030506	ankyrin binding

0.54	GO:0005654	nucleoplasm
0.52	GO:0005887	integral component of plasma membrane

sp|P32455|GBP1_HUMAN
Guanylate-binding protein 1
Search

0.95	Guanylate binding protein 1, interferon-inducible

0.48	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly
0.48	GO:0051260	protein homooligomerization
0.48	GO:0050702	interleukin-1 beta secretion
0.46	GO:0001817	regulation of cytokine production
0.45	GO:0051262	protein tetramerization
0.45	GO:0050860	negative regulation of T cell receptor signaling pathway
0.44	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
0.44	GO:1903077	negative regulation of protein localization to plasma membrane
0.44	GO:0072616	interleukin-18 secretion
0.44	GO:0070373	negative regulation of ERK1 and ERK2 cascade

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0042802	identical protein binding
0.44	GO:0051879	Hsp90 protein binding
0.44	GO:0030507	spectrin binding
0.43	GO:0019955	cytokine binding
0.41	GO:0003779	actin binding

0.46	GO:0005829	cytosol
0.45	GO:0015629	actin cytoskeleton
0.43	GO:0005654	nucleoplasm
0.40	GO:0031410	cytoplasmic vesicle
0.38	GO:0020005	symbiont-containing vacuole membrane
0.30	GO:0016020	membrane

sp|P32456|GBP2_HUMAN
Guanylate-binding protein 2
Search

0.97	Guanylate binding protein 1, interferon-inducible

0.48	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly
0.48	GO:0050702	interleukin-1 beta secretion
0.48	GO:0051260	protein homooligomerization
0.45	GO:0001817	regulation of cytokine production
0.45	GO:0051262	protein tetramerization
0.44	GO:0072616	interleukin-18 secretion
0.44	GO:0050860	negative regulation of T cell receptor signaling pathway
0.44	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
0.44	GO:1903077	negative regulation of protein localization to plasma membrane
0.44	GO:0071346	cellular response to interferon-gamma

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0042802	identical protein binding
0.43	GO:0051879	Hsp90 protein binding
0.43	GO:0030507	spectrin binding
0.42	GO:0019955	cytokine binding
0.40	GO:0003779	actin binding

0.46	GO:0005829	cytosol
0.45	GO:0015629	actin cytoskeleton
0.44	GO:0005654	nucleoplasm
0.40	GO:0031410	cytoplasmic vesicle
0.38	GO:0020005	symbiont-containing vacuole membrane
0.30	GO:0016020	membrane

sp|P32519|ELF1_HUMAN
ETS-related transcription factor Elf-1
Search

ELF1

0.97	LOW QUALITY PROTEIN: ETS-related transcription factor Elf-1

0.61	GO:0050860	negative regulation of T cell receptor signaling pathway
0.59	GO:0045944	positive regulation of transcription by RNA polymerase II
0.57	GO:0006366	transcription by RNA polymerase II
0.56	GO:0001817	regulation of cytokine production
0.52	GO:0001787	natural killer cell proliferation
0.52	GO:0001866	NK T cell proliferation
0.48	GO:0045087	innate immune response
0.45	GO:0030154	cell differentiation
0.36	GO:0050855	regulation of B cell receptor signaling pathway
0.35	GO:0001959	regulation of cytokine-mediated signaling pathway

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.58	GO:0001012	RNA polymerase II regulatory region DNA binding
0.55	GO:0003690	double-stranded DNA binding
0.34	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.39	GO:0031974	membrane-enclosed lumen
0.37	GO:0044446	intracellular organelle part
0.32	GO:0005829	cytosol

sp|P32745|SSR3_HUMAN
Somatostatin receptor type 3
Search

SSTR3

0.94	Type-three somatostatin receptor subtype B

0.86	GO:0038169	somatostatin receptor signaling pathway
0.77	GO:0009755	hormone-mediated signaling pathway
0.50	GO:0090276	regulation of peptide hormone secretion
0.49	GO:0032467	positive regulation of cytokinesis
0.49	GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
0.48	GO:0007268	chemical synaptic transmission
0.47	GO:0042593	glucose homeostasis
0.47	GO:0050708	regulation of protein secretion
0.45	GO:0007218	neuropeptide signaling pathway
0.45	GO:0071385	cellular response to glucocorticoid stimulus

0.86	GO:0004994	somatostatin receptor activity
0.52	GO:0042923	neuropeptide binding
0.50	GO:0005102	receptor binding
0.34	GO:0003924	GTPase activity
0.34	GO:0032550	purine ribonucleoside binding
0.34	GO:0032561	guanyl ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.57	GO:0060170	ciliary membrane
0.55	GO:0097730	non-motile cilium
0.48	GO:0043005	neuron projection
0.44	GO:0005887	integral component of plasma membrane
0.36	GO:0005581	collagen trimer
0.34	GO:0005576	extracellular region
0.33	GO:0005737	cytoplasm

sp|P32754|HPPD_HUMAN
4-hydroxyphenylpyruvate dioxygenase
Search

HPD

0.58	4-hydroxyphenylpyruvate dioxygenase

0.69	GO:0009072	aromatic amino acid family metabolic process
0.53	GO:0055114	oxidation-reduction process
0.44	GO:1901606	alpha-amino acid catabolic process
0.43	GO:1901361	organic cyclic compound catabolic process
0.43	GO:0019439	aromatic compound catabolic process
0.40	GO:1902221	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
0.39	GO:0042737	drug catabolic process

0.82	GO:0003868	4-hydroxyphenylpyruvate dioxygenase activity
0.52	GO:0046872	metal ion binding
0.47	GO:0004462	lactoylglutathione lyase activity

0.45	GO:0000139	Golgi membrane
0.45	GO:0005789	endoplasmic reticulum membrane
0.36	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol

0.82	EC:1.13.11.27	GO:0003868
0.47	KEGG:R02530	GO:0004462

sp|P32780|TF2H1_HUMAN
General transcription factor IIH subunit 1
Search

GTF2H1

0.96	General transcription factor IIH polypeptide 1

0.71	GO:0006289	nucleotide-excision repair
0.57	GO:0006351	transcription, DNA-templated
0.51	GO:0045944	positive regulation of transcription by RNA polymerase II
0.48	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain
0.37	GO:1990830	cellular response to leukemia inhibitory factor
0.35	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
0.35	GO:0031334	positive regulation of protein complex assembly
0.35	GO:0065004	protein-DNA complex assembly
0.34	GO:0006370	7-methylguanosine mRNA capping
0.34	GO:0032392	DNA geometric change

0.57	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.50	GO:0008094	DNA-dependent ATPase activity
0.37	GO:0003682	chromatin binding
0.34	GO:0005515	protein binding

0.79	GO:0000439	core TFIIH complex
0.56	GO:0005675	holo TFIIH complex

0.57

EC:2.7.11.23

GO:0008353

sp|P32856|STX2_HUMAN
Syntaxin-2
Search

STX2

0.97	Epimorphin

0.83	GO:0007340	acrosome reaction
0.69	GO:0030154	cell differentiation
0.69	GO:0016192	vesicle-mediated transport
0.67	GO:0006886	intracellular protein transport
0.66	GO:0061025	membrane fusion
0.55	GO:1903575	cornified envelope assembly
0.54	GO:0033194	response to hydroperoxide
0.53	GO:0097480	establishment of synaptic vesicle localization
0.53	GO:0099504	synaptic vesicle cycle
0.52	GO:0099643	signal release from synapse

0.78	GO:0005484	SNAP receptor activity
0.49	GO:0000149	SNARE binding
0.46	GO:0046983	protein dimerization activity
0.42	GO:0019901	protein kinase binding
0.41	GO:0005102	receptor binding
0.38	GO:0048306	calcium-dependent protein binding
0.35	GO:0019904	protein domain specific binding

0.51	GO:0030027	lamellipodium
0.51	GO:0016323	basolateral plasma membrane
0.51	GO:0098793	presynapse
0.49	GO:0031201	SNARE complex
0.48	GO:0070382	exocytic vesicle
0.47	GO:0005615	extracellular space
0.43	GO:0030424	axon
0.36	GO:1903561	extracellular vesicle
0.36	GO:0005652	nuclear lamina
0.36	GO:0045121	membrane raft

sp|P32881|IFNA8_HUMAN
Interferon alpha-8
Search

0.89	Interferon alpha-N

0.77	GO:0051607	defense response to virus
0.75	GO:0010469	regulation of receptor activity
0.55	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
0.55	GO:0002323	natural killer cell activation involved in immune response
0.54	GO:0042100	B cell proliferation
0.53	GO:0002286	T cell activation involved in immune response
0.53	GO:0043330	response to exogenous dsRNA
0.53	GO:0030183	B cell differentiation
0.51	GO:0002250	adaptive immune response
0.51	GO:0006959	humoral immune response

0.80	GO:0005125	cytokine activity
0.79	GO:0005126	cytokine receptor binding
0.49	GO:0032403	protein complex binding

0.73

GO:0005615

extracellular space

sp|P32926|DSG3_HUMAN
Desmoglein-3
Search

0.93	LOW QUALITY PROTEIN: desmoglein-4

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.54	GO:0030216	keratinocyte differentiation
0.53	GO:0001942	hair follicle development
0.52	GO:0030509	BMP signaling pathway
0.40	GO:0050821	protein stabilization
0.38	GO:0012501	programmed cell death
0.35	GO:0003165	Purkinje myocyte development
0.35	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication
0.35	GO:0098911	regulation of ventricular cardiac muscle cell action potential
0.35	GO:0002934	desmosome organization

0.70	GO:0005509	calcium ion binding
0.42	GO:0045295	gamma-catenin binding
0.34	GO:0050839	cell adhesion molecule binding
0.32	GO:0015643	toxic substance binding

0.57	GO:0030057	desmosome
0.55	GO:0005886	plasma membrane
0.40	GO:0070062	extracellular exosome
0.39	GO:0098562	cytoplasmic side of membrane
0.37	GO:0005914	spot adherens junction
0.36	GO:0005829	cytosol
0.35	GO:0014704	intercalated disc
0.33	GO:0031012	extracellular matrix
0.32	GO:0045177	apical part of cell
0.32	GO:0043231	intracellular membrane-bounded organelle

sp|P32927|IL3RB_HUMAN
Cytokine receptor common subunit beta
Search

CSF2RB

0.94	Cytokine receptor common subunit beta

0.79	GO:0019221	cytokine-mediated signaling pathway
0.42	GO:0036015	response to interleukin-3
0.42	GO:0032496	response to lipopolysaccharide
0.41	GO:0007585	respiratory gaseous exchange
0.40	GO:0000165	MAPK cascade
0.39	GO:0018108	peptidyl-tyrosine phosphorylation
0.37	GO:0001558	regulation of cell growth
0.37	GO:0065009	regulation of molecular function
0.36	GO:0002532	production of molecular mediator involved in inflammatory response

0.81	GO:0004896	cytokine receptor activity
0.39	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.39	GO:0004713	protein tyrosine kinase activity

0.44	GO:0030526	granulocyte macrophage colony-stimulating factor receptor complex
0.33	GO:0005622	intracellular

0.39

GO:0004713

sp|P32929|CGL_HUMAN
Cystathionine gamma-lyase
Search

CTH

0.78	Cystathionase (Cystathionine gamma-lyase)

0.51	GO:0019346	transsulfuration
0.49	GO:0019343	cysteine biosynthetic process via cystathionine
0.47	GO:0071266	'de novo' L-methionine biosynthetic process
0.43	GO:1904831	positive regulation of aortic smooth muscle cell differentiation
0.43	GO:0044524	protein sulfhydration
0.43	GO:0018272	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
0.41	GO:0051289	protein homotetramerization
0.41	GO:1990823	response to leukemia inhibitory factor
0.41	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.41	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling

0.67	GO:0030170	pyridoxal phosphate binding
0.51	GO:0016829	lyase activity
0.49	GO:0003962	cystathionine gamma-synthase activity
0.39	GO:0042802	identical protein binding

0.37

GO:0005737

cytoplasm

0.51

EC:4

GO:0016829

sp|P32942|ICAM3_HUMAN
Intercellular adhesion molecule 3
Search

0.96	Intercellular adhesion molecule

0.74	GO:0098609	cell-cell adhesion
0.50	GO:0002457	T cell antigen processing and presentation
0.50	GO:0006909	phagocytosis
0.50	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
0.49	GO:0022614	membrane to membrane docking
0.49	GO:0002693	positive regulation of cellular extravasation
0.48	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
0.48	GO:0033627	cell adhesion mediated by integrin
0.48	GO:1900027	regulation of ruffle assembly
0.48	GO:0061028	establishment of endothelial barrier

0.60	GO:0005178	integrin binding
0.35	GO:0001618	virus receptor activity
0.33	GO:0004888	transmembrane signaling receptor activity
0.33	GO:0003735	structural constituent of ribosome

0.48	GO:0001772	immunological synapse
0.47	GO:0070062	extracellular exosome
0.46	GO:0009897	external side of plasma membrane
0.46	GO:0098857	membrane microdomain
0.45	GO:0005887	integral component of plasma membrane
0.44	GO:0031012	extracellular matrix
0.34	GO:0005925	focal adhesion
0.33	GO:0005840	ribosome

sp|P32969|RL9_HUMAN
60S ribosomal protein L9
Search

RPL9

0.71	Ribosomal protein L9, pseudogene 6

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.35	GO:1990090	cellular response to nerve growth factor stimulus
0.34	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.34	GO:0019083	viral transcription
0.33	GO:0016072	rRNA metabolic process
0.33	GO:0042254	ribosome biogenesis

0.66	GO:0019843	rRNA binding
0.64	GO:0003735	structural constituent of ribosome
0.33	GO:0005515	protein binding

0.61	GO:0005840	ribosome
0.47	GO:0044445	cytosolic part
0.41	GO:0044446	intracellular organelle part
0.36	GO:0031012	extracellular matrix
0.36	GO:0005925	focal adhesion
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|P32970|CD70_HUMAN
CD70 antigen
Search

sp|P32971|TNFL8_HUMAN
Tumor necrosis factor ligand superfamily member 8
Search

TNFSF8

0.96	Tumor necrosis factor ligand superfamily member 8

0.73	GO:0006955	immune response
0.72	GO:0043374	CD8-positive, alpha-beta T cell differentiation
0.68	GO:0050830	defense response to Gram-positive bacterium
0.61	GO:0045944	positive regulation of transcription by RNA polymerase II
0.59	GO:0010469	regulation of receptor activity
0.39	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.38	GO:0008283	cell proliferation
0.37	GO:0006915	apoptotic process
0.37	GO:0007267	cell-cell signaling

0.83	GO:0005164	tumor necrosis factor receptor binding
0.62	GO:0005125	cytokine activity

0.58	GO:0005615	extracellular space
0.36	GO:0005887	integral component of plasma membrane

sp|P33032|MC5R_HUMAN
Melanocortin receptor 5
Search

MC5R

0.97	Melanocortin receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.52	GO:0019933	cAMP-mediated signaling
0.41	GO:0030819	positive regulation of cAMP biosynthetic process
0.41	GO:2000252	negative regulation of feeding behavior
0.41	GO:0097009	energy homeostasis
0.39	GO:0040008	regulation of growth
0.38	GO:0006112	energy reserve metabolic process

0.84	GO:0004977	melanocortin receptor activity
0.39	GO:0042562	hormone binding
0.33	GO:0005515	protein binding

0.55	GO:0005886	plasma membrane
0.36	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

sp|P33076|C2TA_HUMAN
MHC class II transactivator
Search

CIITA

0.97	Class II major histocompatibility complex transactivator

0.63	GO:0034341	response to interferon-gamma
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.55	GO:1902679	negative regulation of RNA biosynthetic process
0.50	GO:0045348	positive regulation of MHC class II biosynthetic process
0.48	GO:0071257	cellular response to electrical stimulus
0.48	GO:0071360	cellular response to exogenous dsRNA
0.47	GO:0045345	positive regulation of MHC class I biosynthetic process
0.46	GO:0071345	cellular response to cytokine stimulus

0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0033613	activating transcription factor binding
0.45	GO:0008022	protein C-terminus binding
0.43	GO:0044212	transcription regulatory region DNA binding
0.42	GO:0032403	protein complex binding
0.37	GO:0003713	transcription coactivator activity
0.36	GO:0032550	purine ribonucleoside binding
0.36	GO:0019001	guanyl nucleotide binding

0.45	GO:0016605	PML body
0.43	GO:0009986	cell surface

0.36

GO:0016746

sp|P33121|ACSL1_HUMAN
Long-chain-fatty-acid--CoA ligase 1
Search

ACSL1

0.60	Long-chain fatty acid CoA ligase

0.56	GO:0033211	adiponectin-activated signaling pathway
0.56	GO:0044539	long-chain fatty acid import
0.54	GO:0001676	long-chain fatty acid metabolic process
0.51	GO:0071902	positive regulation of protein serine/threonine kinase activity
0.45	GO:0008610	lipid biosynthetic process
0.39	GO:0034201	response to oleic acid
0.38	GO:0007584	response to nutrient
0.37	GO:0006641	triglyceride metabolic process
0.37	GO:0042178	xenobiotic catabolic process
0.37	GO:0014070	response to organic cyclic compound

0.55	GO:0004467	long-chain fatty acid-CoA ligase activity
0.44	GO:0102391	decanoate--CoA ligase activity
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0003987	acetate-CoA ligase activity
0.34	GO:0032555	purine ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0004197	cysteine-type endopeptidase activity

0.44	GO:0005739	mitochondrion
0.38	GO:0031903	microbody membrane
0.38	GO:0044439	peroxisomal part
0.38	GO:0031968	organelle outer membrane
0.37	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.55

EC:6.2.1.3

GO:0004467

sp|P33151|CADH5_HUMAN
Cadherin-5
Search

CDH5

0.80

Cadherin

0.84	GO:0001955	blood vessel maturation
0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.61	GO:1901552	positive regulation of endothelial cell development
0.60	GO:1903140	regulation of establishment of endothelial barrier
0.58	GO:0050728	negative regulation of inflammatory response
0.57	GO:0007043	cell-cell junction assembly
0.57	GO:0045765	regulation of angiogenesis
0.57	GO:0007179	transforming growth factor beta receptor signaling pathway
0.56	GO:1904018	positive regulation of vasculature development
0.54	GO:2000114	regulation of establishment of cell polarity

0.70	GO:0005509	calcium ion binding
0.58	GO:0044325	ion channel binding
0.57	GO:0008013	beta-catenin binding
0.56	GO:0019903	protein phosphatase binding
0.51	GO:0005102	receptor binding
0.33	GO:0042802	identical protein binding

0.57	GO:0005913	cell-cell adherens junction
0.55	GO:0005886	plasma membrane
0.55	GO:0005923	bicellular tight junction
0.53	GO:0009986	cell surface
0.52	GO:0098552	side of membrane
0.33	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

sp|P33176|KINH_HUMAN
Kinesin-1 heavy chain
Search

KIF5B

0.85	Kinesin-1 heavy chain

0.74	GO:0007018	microtubule-based movement
0.72	GO:1905152	positive regulation of voltage-gated sodium channel activity
0.68	GO:0035617	stress granule disassembly
0.67	GO:0032230	positive regulation of synaptic transmission, GABAergic
0.66	GO:0031340	positive regulation of vesicle fusion
0.65	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
0.65	GO:0007028	cytoplasm organization
0.65	GO:0051642	centrosome localization
0.64	GO:1903078	positive regulation of protein localization to plasma membrane
0.64	GO:0021766	hippocampus development

0.75	GO:0003777	microtubule motor activity
0.70	GO:0099609	microtubule lateral binding
0.67	GO:0008432	JUN kinase binding
0.61	GO:0045296	cadherin binding
0.56	GO:0042802	identical protein binding
0.50	GO:0042623	ATPase activity, coupled
0.49	GO:0032559	adenyl ribonucleotide binding
0.49	GO:0008144	drug binding
0.49	GO:0035639	purine ribonucleoside triphosphate binding

0.66	GO:0035253	ciliary rootlet
0.65	GO:0044295	axonal growth cone
0.62	GO:0045335	phagocytic vesicle
0.61	GO:0005871	kinesin complex
0.60	GO:0048471	perinuclear region of cytoplasm
0.57	GO:0005815	microtubule organizing center
0.56	GO:0005874	microtubule
0.53	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|P33240|CSTF2_HUMAN
Cleavage stimulation factor subunit 2
Search

CSTF2

0.88	Cleavage stimulation factor subunit 2 tau variant

0.79	GO:0031124	mRNA 3'-end processing
0.76	GO:0043631	RNA polyadenylation
0.52	GO:0098787	mRNA cleavage involved in mRNA processing
0.43	GO:1990090	cellular response to nerve growth factor stimulus
0.38	GO:0006369	termination of RNA polymerase II transcription
0.37	GO:0000398	mRNA splicing, via spliceosome
0.36	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation

0.59	GO:0003723	RNA binding
0.35	GO:0005515	protein binding

0.79	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
0.52	GO:0016604	nuclear body

sp|P33241|LSP1_HUMAN
Lymphocyte-specific protein 1
Search

LSP1

0.97	Lymphocyte-specific protein 1

0.60	GO:0007165	signal transduction
0.48	GO:0006952	defense response
0.46	GO:0006935	chemotaxis
0.41	GO:0006936	muscle contraction
0.35	GO:0006915	apoptotic process
0.35	GO:0007010	cytoskeleton organization
0.34	GO:0006942	regulation of striated muscle contraction

0.63	GO:0004871	signal transducer activity
0.42	GO:0003779	actin binding
0.42	GO:0017022	myosin binding
0.40	GO:0005516	calmodulin binding

0.41	GO:0005886	plasma membrane
0.39	GO:0070062	extracellular exosome
0.38	GO:0015629	actin cytoskeleton
0.36	GO:0036379	myofilament
0.36	GO:0030017	sarcomere
0.35	GO:0044430	cytoskeletal part
0.33	GO:0043234	protein complex

sp|P33260|CP2CI_HUMAN
Cytochrome P450 2C18
Search

0.96	Cytochrome P450 family 2 subfamily C polypeptide 9

0.56	GO:0042738	exogenous drug catabolic process
0.53	GO:0055114	oxidation-reduction process
0.50	GO:0002933	lipid hydroxylation
0.49	GO:0008202	steroid metabolic process
0.49	GO:0070988	demethylation
0.48	GO:0016098	monoterpenoid metabolic process
0.42	GO:0019373	epoxygenase P450 pathway
0.40	GO:0019627	urea metabolic process
0.34	GO:0046483	heterocycle metabolic process

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.66	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.54	GO:0034875	caffeine oxidase activity
0.39	GO:0019899	enzyme binding
0.35	GO:0008144	drug binding

0.43	GO:0005789	endoplasmic reticulum membrane
0.40	GO:0031090	organelle membrane
0.30	GO:0031224	intrinsic component of membrane

0.68

EC:1.14

GO:0016705

sp|P33261|CP2CJ_HUMAN
Cytochrome P450 2C19
Search

0.97	Cytochrome P450 family 2 subfamily C polypeptide 9

0.58	GO:0042738	exogenous drug catabolic process
0.53	GO:0055114	oxidation-reduction process
0.51	GO:0008202	steroid metabolic process
0.51	GO:0002933	lipid hydroxylation
0.50	GO:0070988	demethylation
0.50	GO:0016098	monoterpenoid metabolic process
0.43	GO:0019373	epoxygenase P450 pathway
0.40	GO:0019627	urea metabolic process
0.35	GO:0046483	heterocycle metabolic process

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.67	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.55	GO:0034875	caffeine oxidase activity
0.40	GO:0019899	enzyme binding
0.35	GO:0008144	drug binding

0.42	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0031090	organelle membrane
0.30	GO:0031224	intrinsic component of membrane

0.68

EC:1.14

GO:0016705

sp|P33316|DUT_HUMAN
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Search

DUT

0.45	Deoxyuridine 5'-triphosphate nucleotidohydrolase

0.78	GO:0046080	dUTP metabolic process
0.52	GO:0009213	pyrimidine deoxyribonucleoside triphosphate catabolic process
0.52	GO:0009223	pyrimidine deoxyribonucleotide catabolic process
0.48	GO:0006226	dUMP biosynthetic process
0.42	GO:0043497	regulation of protein heterodimerization activity
0.41	GO:0070207	protein homotrimerization
0.41	GO:2000272	negative regulation of receptor activity
0.41	GO:0001889	liver development
0.39	GO:0015949	nucleobase-containing small molecule interconversion
0.39	GO:0014070	response to organic cyclic compound

0.79	GO:0004170	dUTP diphosphatase activity
0.43	GO:0032556	pyrimidine deoxyribonucleotide binding
0.43	GO:0000287	magnesium ion binding
0.42	GO:0042975	peroxisome proliferator activated receptor binding
0.41	GO:0030547	receptor inhibitor activity
0.36	GO:0003723	RNA binding
0.34	GO:0032550	purine ribonucleoside binding
0.34	GO:0032561	guanyl ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.51	GO:0005654	nucleoplasm
0.45	GO:0005739	mitochondrion
0.40	GO:0070062	extracellular exosome
0.38	GO:0005829	cytosol

0.79	EC:3.6.1.23	GO:0004170
0.79	KEGG:R02100	GO:0004170

sp|P33402|GCYA2_HUMAN
Guanylate cyclase soluble subunit alpha-2
Search

GUCY1A2

0.94	Guanylate cyclase soluble subunit alpha-2

0.80	GO:0006182	cGMP biosynthetic process
0.61	GO:0030828	positive regulation of cGMP biosynthetic process
0.61	GO:0035556	intracellular signal transduction
0.43	GO:0052565	response to defense-related host nitric oxide production
0.42	GO:0060087	relaxation of vascular smooth muscle
0.41	GO:0008217	regulation of blood pressure
0.38	GO:0090594	inflammatory response to wounding

0.81	GO:0004383	guanylate cyclase activity
0.60	GO:0020037	heme binding
0.51	GO:1901265	nucleoside phosphate binding
0.50	GO:0036094	small molecule binding
0.48	GO:0004016	adenylate cyclase activity
0.36	GO:0005515	protein binding
0.34	GO:0097367	carbohydrate derivative binding
0.34	GO:0043168	anion binding
0.33	GO:0004872	receptor activity

0.53	GO:0008074	guanylate cyclase complex, soluble
0.40	GO:0005886	plasma membrane
0.34	GO:0048786	presynaptic active zone
0.30	GO:0016021	integral component of membrane

0.81

GO:0004383

sp|P33527|MRP1_HUMAN
Multidrug resistance-associated protein 1
Search

ABCC1

0.80	LOW QUALITY PROTEIN: multidrug resistance-associated protein 1

0.55	GO:0055085	transmembrane transport
0.48	GO:0099039	sphingolipid translocation
0.45	GO:0042908	xenobiotic transport
0.45	GO:0034635	glutathione transport
0.43	GO:0045332	phospholipid translocation
0.42	GO:0015893	drug transport
0.41	GO:0071585	detoxification of cadmium ion
0.37	GO:0060326	cell chemotaxis
0.36	GO:1905701	positive regulation of drug transmembrane export
0.36	GO:0006691	leukotriene metabolic process

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0034634	glutathione transmembrane transporter activity
0.48	GO:0046623	sphingolipid-translocating ATPase activity
0.45	GO:0042910	xenobiotic transmembrane transporter activity
0.44	GO:0004012	phospholipid-translocating ATPase activity
0.43	GO:0015238	drug transmembrane transporter activity
0.35	GO:0005324	long-chain fatty acid transporter activity

0.50	GO:0016323	basolateral plasma membrane
0.44	GO:0005887	integral component of plasma membrane
0.37	GO:0070062	extracellular exosome
0.32	GO:0005737	cytoplasm

0.44	EC:3.6.3.1	GO:0004012
0.34	KEGG:R04371	GO:0004409

sp|P33552|CKS2_HUMAN
Cyclin-dependent kinases regulatory subunit 2
Search

CKS2

0.68	Cyclin-dependent kinases regulatory subunit

0.76	GO:0045859	regulation of protein kinase activity
0.67	GO:0051301	cell division
0.67	GO:0007049	cell cycle
0.53	GO:0008283	cell proliferation
0.50	GO:0045787	positive regulation of cell cycle
0.49	GO:0033674	positive regulation of kinase activity
0.49	GO:0016310	phosphorylation
0.49	GO:0001934	positive regulation of protein phosphorylation
0.48	GO:0007346	regulation of mitotic cell cycle
0.47	GO:0045893	positive regulation of transcription, DNA-templated

0.82	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.52	GO:0043539	protein serine/threonine kinase activator activity
0.51	GO:0016301	kinase activity
0.50	GO:0043130	ubiquitin binding
0.50	GO:0042393	histone binding
0.49	GO:0019901	protein kinase binding
0.47	GO:0003682	chromatin binding

0.51	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
0.51	GO:0019005	SCF ubiquitin ligase complex
0.33	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.82

GO:0016538

sp|P33681|CD80_HUMAN
T-lymphocyte activation antigen CD80
Search

CD80

0.97	T-cell specific surface glycoprotein B7-1

0.86	GO:0031295	T cell costimulation
0.65	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
0.60	GO:0007165	signal transduction
0.48	GO:0046635	positive regulation of alpha-beta T cell activation
0.46	GO:0046640	regulation of alpha-beta T cell proliferation
0.45	GO:0042102	positive regulation of T cell proliferation
0.45	GO:0071222	cellular response to lipopolysaccharide
0.41	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
0.40	GO:0045625	regulation of T-helper 1 cell differentiation
0.40	GO:0045086	positive regulation of interleukin-2 biosynthetic process

0.85	GO:0015026	coreceptor activity
0.40	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.40	GO:0104005	hijacked molecular function
0.37	GO:0005515	protein binding

0.60	GO:0098636	protein complex involved in cell adhesion
0.45	GO:0009986	cell surface
0.42	GO:0098552	side of membrane
0.39	GO:0044459	plasma membrane part
0.33	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

0.40	EC:2.7.1.153	GO:0046934
0.40	KEGG:R04545	GO:0046934

sp|P33763|S10A5_HUMAN
Protein S100-A5
Search

0.10	S100 calcium binding protein A5

0.42	GO:0043542	endothelial cell migration
0.35	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling

0.70	GO:0005509	calcium ion binding
0.62	GO:0042802	identical protein binding
0.56	GO:0046983	protein dimerization activity
0.56	GO:0046914	transition metal ion binding
0.48	GO:0044548	S100 protein binding
0.47	GO:0048306	calcium-dependent protein binding
0.47	GO:0005523	tropomyosin binding
0.36	GO:0050786	RAGE receptor binding

0.61	GO:0043025	neuronal cell body
0.51	GO:0005634	nucleus
0.46	GO:0001726	ruffle
0.46	GO:0048471	perinuclear region of cytoplasm
0.45	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.42	GO:0005829	cytosol
0.42	GO:0005576	extracellular region
0.42	GO:0012505	endomembrane system
0.40	GO:0031967	organelle envelope

sp|P33764|S10A3_HUMAN
Protein S100-A3
Search

S100A3

0.97	EF-HAND 2 containing protein

0.37

GO:0008016

regulation of heart contraction

0.70	GO:0005509	calcium ion binding
0.62	GO:0008270	zinc ion binding

0.63	GO:0005730	nucleolus
0.60	GO:0005829	cytosol

sp|P33778|H2B1B_HUMAN
Histone H2B type 1-B
Search

sp|P33897|ABCD1_HUMAN
ATP-binding cassette sub-family D member 1
Search

ABCD1

0.88	ATP-binding cassette sub-family D member 1

0.77	GO:0006635	fatty acid beta-oxidation
0.74	GO:0000038	very long-chain fatty acid metabolic process
0.62	GO:0015910	peroxisomal long-chain fatty acid import
0.55	GO:0055085	transmembrane transport
0.54	GO:0042758	long-chain fatty acid catabolic process
0.54	GO:0032000	positive regulation of fatty acid beta-oxidation
0.50	GO:0007031	peroxisome organization
0.43	GO:0030301	cholesterol transport
0.36	GO:0036109	alpha-linolenic acid metabolic process
0.36	GO:0043651	linoleic acid metabolic process

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.62	GO:0005324	long-chain fatty acid transporter activity
0.55	GO:0042803	protein homodimerization activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0019899	enzyme binding
0.35	GO:0017154	semaphorin receptor activity
0.33	GO:0004672	protein kinase activity

0.76	GO:0005777	peroxisome
0.66	GO:0031903	microbody membrane
0.50	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0031301	integral component of organelle membrane
0.43	GO:0005739	mitochondrion
0.35	GO:0005829	cytosol

sp|P33908|MA1A1_HUMAN
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
Search

MAN1A1

0.47	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

0.52	GO:0006491	N-glycan processing
0.47	GO:0007585	respiratory gaseous exchange
0.47	GO:0048286	lung alveolus development
0.39	GO:0006486	protein glycosylation
0.37	GO:0036507	protein demannosylation

0.82	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
0.70	GO:0005509	calcium ion binding

0.55	GO:0000139	Golgi membrane
0.55	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.47	GO:0005829	cytosol
0.46	GO:0005783	endoplasmic reticulum
0.39	GO:0070062	extracellular exosome
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.30	GO:0016021	integral component of membrane

0.82	EC:3.2.1.113	GO:0004571
0.82	KEGG:R05982 KEGG:R06722	GO:0004571

sp|P33947|ERD22_HUMAN
ER lumen protein-retaining receptor 2
Search

KDELR2

0.66	ER lumen protein-retaining receptor

0.84	GO:0006621	protein retention in ER lumen
0.64	GO:0015031	protein transport
0.38	GO:0016192	vesicle-mediated transport
0.35	GO:0002369	T cell cytokine production
0.35	GO:0070231	T cell apoptotic process
0.34	GO:0030217	T cell differentiation
0.33	GO:0046907	intracellular transport
0.33	GO:0006629	lipid metabolic process

0.84	GO:0046923	ER retention sequence binding
0.33	GO:0003676	nucleic acid binding
0.32	GO:0016787	hydrolase activity

0.71	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0005801	cis-Golgi network
0.36	GO:0070062	extracellular exosome
0.35	GO:0005794	Golgi apparatus
0.34	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.34	GO:0030133	transport vesicle
0.33	GO:0098588	bounding membrane of organelle
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016787

sp|P33981|TTK_HUMAN
Dual specificity protein kinase TTK
Search

TTK

0.92	Dual specificity protein kinase TTK

0.80	GO:0007093	mitotic cell cycle checkpoint
0.79	GO:0051304	chromosome separation
0.66	GO:1903096	protein localization to meiotic spindle midzone
0.63	GO:0006468	protein phosphorylation
0.62	GO:0016321	female meiosis chromosome segregation
0.62	GO:0044779	meiotic spindle checkpoint
0.60	GO:0034501	protein localization to kinetochore
0.59	GO:0018210	peptidyl-threonine modification
0.58	GO:0071173	spindle assembly checkpoint
0.58	GO:0018209	peptidyl-serine modification

0.81	GO:0004712	protein serine/threonine/tyrosine kinase activity
0.54	GO:0042803	protein homodimerization activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0004674	protein serine/threonine kinase activity
0.39	GO:0004713	protein tyrosine kinase activity
0.38	GO:0043515	kinetochore binding

0.56	GO:0000776	kinetochore
0.40	GO:0005737	cytoplasm
0.36	GO:0005819	spindle
0.33	GO:0005816	spindle pole body
0.33	GO:0000780	condensed nuclear chromosome, centromeric region
0.30	GO:0016021	integral component of membrane

0.81

EC:2.7.12.1

GO:0004712

sp|P33991|MCM4_HUMAN
DNA replication licensing factor MCM4
Search

MCM4

0.44	DNA helicase

0.74	GO:0006270	DNA replication initiation
0.69	GO:0032392	DNA geometric change
0.46	GO:0001878	response to yeast

0.69	GO:0003678	DNA helicase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0003677	DNA binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0070035	purine NTP-dependent helicase activity
0.47	GO:0008094	DNA-dependent ATPase activity
0.42	GO:0003682	chromatin binding

0.78	GO:0042555	MCM complex
0.60	GO:0005634	nucleus
0.46	GO:0031974	membrane-enclosed lumen
0.42	GO:0044446	intracellular organelle part
0.33	GO:0005694	chromosome
0.30	GO:0016020	membrane

sp|P33992|MCM5_HUMAN
DNA replication licensing factor MCM5
Search

MCM5

0.43	DNA replication licensing factor mcm5-A

0.75	GO:0006270	DNA replication initiation
0.70	GO:0032392	DNA geometric change
0.43	GO:0007049	cell cycle
0.43	GO:0043009	chordate embryonic development
0.42	GO:0043066	negative regulation of apoptotic process
0.39	GO:0035825	homologous recombination
0.38	GO:0000280	nuclear division
0.38	GO:0030261	chromosome condensation
0.37	GO:0007059	chromosome segregation
0.37	GO:0030174	regulation of DNA-dependent DNA replication initiation

0.78	GO:0003688	DNA replication origin binding
0.77	GO:0003682	chromatin binding
0.70	GO:0003678	DNA helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0004392	heme oxygenase (decyclizing) activity
0.35	GO:0005515	protein binding
0.34	GO:0016887	ATPase activity
0.33	GO:0003924	GTPase activity

0.79	GO:0042555	MCM complex
0.61	GO:0005634	nucleus
0.47	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.38	GO:0005829	cytosol
0.38	GO:0005694	chromosome
0.30	GO:0031224	intrinsic component of membrane

0.36

EC:1.14.99.3

GO:0004392

sp|P33993|MCM7_HUMAN
DNA replication licensing factor MCM7
Search

MCM7

0.42	DNA replication licensing factor mcm7-A

0.75	GO:0006270	DNA replication initiation
0.70	GO:0032392	DNA geometric change
0.52	GO:0008283	cell proliferation
0.51	GO:0071466	cellular response to xenobiotic stimulus
0.49	GO:0042325	regulation of phosphorylation
0.45	GO:0006974	cellular response to DNA damage stimulus
0.41	GO:0071364	cellular response to epidermal growth factor stimulus
0.38	GO:0042493	response to drug
0.37	GO:0007049	cell cycle
0.37	GO:0030174	regulation of DNA-dependent DNA replication initiation

0.71	GO:0003678	DNA helicase activity
0.55	GO:0030554	adenyl nucleotide binding
0.55	GO:0003677	DNA binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0070035	purine NTP-dependent helicase activity
0.47	GO:0008094	DNA-dependent ATPase activity
0.37	GO:0003682	chromatin binding
0.36	GO:0005515	protein binding

0.80	GO:0042555	MCM complex
0.61	GO:0005634	nucleus
0.47	GO:0005829	cytosol
0.47	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.37	GO:0005694	chromosome
0.30	GO:0016020	membrane

sp|P34059|GALNS_HUMAN
N-acetylgalactosamine-6-sulfatase
Search

GALNS

0.83	N-acetylgalactosamine-6-sulfatase

0.36	GO:0042340	keratan sulfate catabolic process
0.36	GO:0043312	neutrophil degranulation
0.34	GO:0019083	viral transcription
0.33	GO:0001172	transcription, RNA-templated
0.33	GO:0009116	nucleoside metabolic process

0.83	GO:0043890	N-acetylgalactosamine-6-sulfatase activity
0.36	GO:0003943	N-acetylgalactosamine-4-sulfatase activity
0.35	GO:0046872	metal ion binding
0.33	GO:0003968	RNA-directed 5'-3' RNA polymerase activity
0.32	GO:0003723	RNA binding

0.39	GO:0005764	lysosome
0.37	GO:0070062	extracellular exosome
0.36	GO:0034774	secretory granule lumen
0.35	GO:0005775	vacuolar lumen

0.83

EC:3.1.6.4

GO:0043890

sp|P34096|RNAS4_HUMAN
Ribonuclease 4
Search

RNASE4

0.48	LOW QUALITY PROTEIN: ribonuclease 4

0.62	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.39	GO:0016070	RNA metabolic process
0.37	GO:0009267	cellular response to starvation
0.33	GO:0048583	regulation of response to stimulus
0.33	GO:0002697	regulation of immune effector process
0.33	GO:0043900	regulation of multi-organism process
0.33	GO:0010646	regulation of cell communication
0.33	GO:0023051	regulation of signaling

0.64	GO:0004519	endonuclease activity
0.51	GO:0003676	nucleic acid binding
0.45	GO:0004540	ribonuclease activity

0.50	GO:0005576	extracellular region
0.36	GO:0031982	vesicle
0.33	GO:0046658	anchored component of plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P34130|NTF4_HUMAN
Neurotrophin-4
Search

NTF3

0.61	Neurotrophin 4

0.75	GO:0010469	regulation of receptor activity
0.56	GO:0061193	taste bud development
0.56	GO:0007402	ganglion mother cell fate determination
0.54	GO:0008052	sensory organ boundary specification
0.53	GO:0060384	innervation
0.52	GO:0007616	long-term memory
0.52	GO:0042490	mechanoreceptor differentiation
0.52	GO:0008344	adult locomotory behavior
0.51	GO:0008544	epidermis development
0.50	GO:0060548	negative regulation of cell death

0.78	GO:0008083	growth factor activity
0.68	GO:0005165	neurotrophin receptor binding
0.44	GO:0008191	metalloendopeptidase inhibitor activity
0.42	GO:0090729	toxin activity
0.34	GO:0005123	death receptor binding

0.55	GO:0005576	extracellular region
0.43	GO:0031410	cytoplasmic vesicle
0.35	GO:0005788	endoplasmic reticulum lumen
0.30	GO:0016020	membrane

sp|P34741|SDC2_HUMAN
Syndecan-2
Search

SDC2

0.82

Syndecan

0.55	GO:0048814	regulation of dendrite morphogenesis
0.47	GO:0016477	cell migration
0.47	GO:0048813	dendrite morphogenesis
0.42	GO:0055113	epiboly involved in gastrulation with mouth forming second
0.41	GO:0070121	Kupffer's vesicle development
0.41	GO:0002040	sprouting angiogenesis
0.40	GO:0048565	digestive tract development
0.40	GO:0007507	heart development
0.39	GO:0097435	supramolecular fiber organization
0.36	GO:0042060	wound healing

0.57	GO:0030165	PDZ domain binding
0.52	GO:0042802	identical protein binding
0.34	GO:0070053	thrombospondin receptor activity
0.33	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding

0.52	GO:0031012	extracellular matrix
0.45	GO:0009986	cell surface
0.38	GO:0005796	Golgi lumen
0.36	GO:0043202	lysosomal lumen
0.35	GO:0005788	endoplasmic reticulum lumen
0.35	GO:0043025	neuronal cell body
0.34	GO:0045202	synapse
0.33	GO:0005886	plasma membrane
0.33	GO:0005925	focal adhesion
0.30	GO:0016021	integral component of membrane

sp|P34810|CD68_HUMAN
Macrosialin
Search

CD68

0.97	Macrosialin

0.43	GO:0071310	cellular response to organic substance
0.30	GO:0051234	establishment of localization
0.30	GO:0002263	cell activation involved in immune response
0.30	GO:0002443	leukocyte mediated immunity
0.30	GO:0045321	leukocyte activation

0.82	GO:0005765	lysosomal membrane
0.41	GO:0010008	endosome membrane
0.36	GO:0005886	plasma membrane
0.30	GO:0030659	cytoplasmic vesicle membrane
0.30	GO:0042582	azurophil granule
0.30	GO:0044425	membrane part

sp|P34820|BMP8B_HUMAN
Bone morphogenetic protein 8B
Search

0.85	Bone morphogenetic protein 5

0.74	GO:0010469	regulation of receptor activity
0.57	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.56	GO:0060395	SMAD protein signal transduction
0.55	GO:0030509	BMP signaling pathway
0.52	GO:0043408	regulation of MAPK cascade
0.52	GO:0048468	cell development
0.50	GO:0042981	regulation of apoptotic process
0.45	GO:0001503	ossification
0.45	GO:0002024	diet induced thermogenesis
0.45	GO:2000505	regulation of energy homeostasis

0.77	GO:0008083	growth factor activity
0.59	GO:0070700	BMP receptor binding
0.56	GO:0005160	transforming growth factor beta receptor binding
0.53	GO:0005125	cytokine activity
0.35	GO:0008410	CoA-transferase activity
0.34	GO:0046982	protein heterodimerization activity
0.34	GO:0008017	microtubule binding
0.33	GO:0005509	calcium ion binding
0.32	GO:0003779	actin binding
0.32	GO:0030554	adenyl nucleotide binding

0.65	GO:0005576	extracellular region
0.34	GO:0031982	vesicle
0.32	GO:0005737	cytoplasm
0.32	GO:0005856	cytoskeleton
0.32	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016020	membrane

0.35

EC:2.8.3

GO:0008410

sp|P34896|GLYC_HUMAN
Serine hydroxymethyltransferase, cytosolic
Search

SHMT1

0.47	Serine hydroxymethyltransferase

0.77	GO:0019264	glycine biosynthetic process from serine
0.73	GO:0035999	tetrahydrofolate interconversion
0.59	GO:1904481	response to tetrahydrofolate
0.57	GO:0006565	L-serine catabolic process
0.55	GO:0051289	protein homotetramerization
0.53	GO:0032259	methylation
0.52	GO:0071229	cellular response to acid chemical
0.52	GO:0071417	cellular response to organonitrogen compound
0.51	GO:0046655	folic acid metabolic process
0.51	GO:0071407	cellular response to organic cyclic compound

0.77	GO:0004372	glycine hydroxymethyltransferase activity
0.66	GO:0030170	pyridoxal phosphate binding
0.58	GO:0070905	serine binding
0.56	GO:0000900	translation repressor activity, nucleic acid binding
0.54	GO:0008168	methyltransferase activity
0.52	GO:0048027	mRNA 5'-UTR binding
0.50	GO:0042803	protein homodimerization activity
0.38	GO:0008732	L-allo-threonine aldolase activity
0.33	GO:0004843	thiol-dependent ubiquitin-specific protease activity

0.51	GO:0005829	cytosol
0.47	GO:0005634	nucleus
0.41	GO:0005739	mitochondrion
0.37	GO:0070062	extracellular exosome

0.77

EC:2.1.2.1

GO:0004372

sp|P34897|GLYM_HUMAN
Serine hydroxymethyltransferase, mitochondrial
Search

SHMT2

0.47	Serine hydroxymethyltransferase

0.76	GO:0019264	glycine biosynthetic process from serine
0.73	GO:0035999	tetrahydrofolate interconversion
0.57	GO:0034340	response to type I interferon
0.55	GO:0070536	protein K63-linked deubiquitination
0.53	GO:0051262	protein tetramerization
0.51	GO:0032259	methylation
0.38	GO:0008284	positive regulation of cell proliferation
0.38	GO:0051260	protein homooligomerization
0.38	GO:0006564	L-serine biosynthetic process
0.34	GO:0046655	folic acid metabolic process

0.77	GO:0004372	glycine hydroxymethyltransferase activity
0.66	GO:0030170	pyridoxal phosphate binding
0.51	GO:0003682	chromatin binding
0.51	GO:0008168	methyltransferase activity
0.41	GO:0008732	L-allo-threonine aldolase activity
0.38	GO:0016597	amino acid binding
0.38	GO:0042802	identical protein binding

0.55	GO:0070552	BRISC complex
0.54	GO:0042645	mitochondrial nucleoid
0.49	GO:0015630	microtubule cytoskeleton
0.45	GO:0031966	mitochondrial membrane
0.45	GO:0019866	organelle inner membrane
0.39	GO:0005758	mitochondrial intermembrane space
0.36	GO:0070062	extracellular exosome

0.77

EC:2.1.2.1

GO:0004372

sp|P34903|GBRA3_HUMAN
Gamma-aminobutyric acid receptor subunit alpha-3
Search

GABRA3

0.97	Gamma-aminobutyric acid receptor subunit alpha-3

0.70	GO:0007214	gamma-aminobutyric acid signaling pathway
0.63	GO:0006821	chloride transport
0.60	GO:0034220	ion transmembrane transport
0.38	GO:0060384	innervation
0.38	GO:0001662	behavioral fear response
0.38	GO:0090102	cochlea development
0.38	GO:0060119	inner ear receptor cell development
0.38	GO:0008306	associative learning
0.38	GO:0043524	negative regulation of neuron apoptotic process
0.37	GO:0007605	sensory perception of sound

0.84	GO:0004890	GABA-A receptor activity
0.75	GO:0005230	extracellular ligand-gated ion channel activity
0.38	GO:0005254	chloride channel activity
0.36	GO:0008503	benzodiazepine receptor activity
0.34	GO:0005515	protein binding

0.55	GO:0005886	plasma membrane
0.49	GO:1902711	GABA-A receptor complex
0.39	GO:0034707	chloride channel complex
0.38	GO:0098794	postsynapse
0.38	GO:0030054	cell junction
0.37	GO:0030425	dendrite
0.37	GO:0044297	cell body
0.36	GO:0005654	nucleoplasm
0.36	GO:0005829	cytosol

sp|P34910|EVI2B_HUMAN
Protein EVI2B
Search

EVI2B

0.40	Putative mlx interactor

0.30

GO:0044425

membrane part

sp|P34913|HYES_HUMAN
Bifunctional epoxide hydrolase 2
Search

EPHX2

0.72	Soluble epoxide hydrolase

0.62	GO:0046272	stilbene catabolic process
0.60	GO:0097176	epoxide metabolic process
0.58	GO:0090181	regulation of cholesterol metabolic process
0.56	GO:0042632	cholesterol homeostasis
0.55	GO:0046839	phospholipid dephosphorylation
0.50	GO:0010628	positive regulation of gene expression
0.38	GO:0060841	venous blood vessel development
0.38	GO:0033559	unsaturated fatty acid metabolic process
0.38	GO:0008217	regulation of blood pressure
0.38	GO:0009636	response to toxic substance

0.59	GO:0004301	epoxide hydrolase activity
0.59	GO:0042577	lipid phosphatase activity
0.55	GO:0015643	toxic substance binding
0.52	GO:0042803	protein homodimerization activity
0.50	GO:0005102	receptor binding
0.47	GO:0000287	magnesium ion binding
0.43	GO:0033885	10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity

0.53	GO:0005777	peroxisome
0.49	GO:0005829	cytosol
0.38	GO:0070062	extracellular exosome

0.59	EC:3.3.2.10	GO:0004301
0.43	KEGG:R07582	GO:0033885

sp|P34925|RYK_HUMAN
Tyrosine-protein kinase RYK
Search

RYK

0.94	Tyrosine-protein kinase RYK-like

0.74	GO:0036518	chemorepulsion of dopaminergic neuron axon
0.73	GO:0035567	non-canonical Wnt signaling pathway
0.72	GO:0071679	commissural neuron axon guidance
0.72	GO:0048843	negative regulation of axon extension involved in axon guidance
0.72	GO:1904948	midbrain dopaminergic neuron differentiation
0.71	GO:0022038	corpus callosum development
0.68	GO:0090175	regulation of establishment of planar polarity
0.66	GO:0048705	skeletal system morphogenesis
0.63	GO:0006468	protein phosphorylation
0.53	GO:0060030	dorsal convergence

0.73	GO:0017147	Wnt-protein binding
0.69	GO:0005109	frizzled binding
0.68	GO:0042813	Wnt-activated receptor activity
0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.51	GO:0005634	nucleus
0.50	GO:0005886	plasma membrane
0.43	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|P34931|HS71L_HUMAN
Heat shock 70 kDa protein 1-like
Search

0.62	Epididymis secretory protein Li 103

0.53	GO:0007339	binding of sperm to zona pellucida
0.52	GO:0010638	positive regulation of organelle organization
0.52	GO:0042026	protein refolding
0.51	GO:1903749	positive regulation of establishment of protein localization to mitochondrion
0.51	GO:1903214	regulation of protein targeting to mitochondrion
0.50	GO:0090316	positive regulation of intracellular protein transport
0.47	GO:0010968	regulation of microtubule nucleation
0.46	GO:1901673	regulation of mitotic spindle assembly
0.44	GO:0032273	positive regulation of protein polymerization
0.44	GO:1902905	positive regulation of supramolecular fiber organization

0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.50	GO:0031625	ubiquitin protein ligase binding
0.50	GO:0031072	heat shock protein binding
0.47	GO:0051082	unfolded protein binding
0.41	GO:0055131	C3HC4-type RING finger domain binding
0.40	GO:0031249	denatured protein binding
0.40	GO:0001106	RNA polymerase II transcription corepressor activity

0.54	GO:0002199	zona pellucida receptor complex
0.50	GO:0044297	cell body
0.50	GO:0008180	COP9 signalosome
0.46	GO:0005829	cytosol
0.43	GO:0005813	centrosome
0.41	GO:0072562	blood microparticle
0.40	GO:0016235	aggresome
0.39	GO:0070013	intracellular organelle lumen
0.39	GO:0005814	centriole
0.39	GO:0070062	extracellular exosome

0.35	EC:6.1.1.9	GO:0004832
0.35	KEGG:R03665	GO:0004832

sp|P34932|HSP74_HUMAN
Heat shock 70 kDa protein 4
Search

HSPA4

0.94	Epididymis secretory sperm binding protein Li 5a

0.55	GO:0045040	protein import into mitochondrial outer membrane
0.54	GO:0051131	chaperone-mediated protein complex assembly
0.35	GO:0043392	negative regulation of DNA binding
0.35	GO:0032092	positive regulation of protein binding
0.35	GO:0045766	positive regulation of angiogenesis
0.35	GO:0006986	response to unfolded protein
0.35	GO:0001822	kidney development
0.34	GO:0043066	negative regulation of apoptotic process
0.34	GO:0009408	response to heat
0.34	GO:0001933	negative regulation of protein phosphorylation

0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0005515	protein binding
0.34	GO:0044877	macromolecular complex binding
0.33	GO:0046872	metal ion binding

0.53	GO:0070062	extracellular exosome
0.47	GO:0005829	cytosol
0.35	GO:0005811	lipid droplet
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P34947|GRK5_HUMAN
G protein-coupled receptor kinase 5
Search

GRK5

0.69	G protein-coupled receptor kinase

0.63	GO:0006468	protein phosphorylation
0.60	GO:0007165	signal transduction
0.54	GO:0008284	positive regulation of cell proliferation
0.53	GO:0043066	negative regulation of apoptotic process
0.51	GO:0051726	regulation of cell cycle
0.49	GO:0045444	fat cell differentiation
0.41	GO:0035469	determination of pancreatic left/right asymmetry
0.40	GO:1902017	regulation of cilium assembly
0.40	GO:0001947	heart looping
0.40	GO:0032007	negative regulation of TOR signaling

0.85	GO:0004703	G-protein coupled receptor kinase activity
0.61	GO:0047696	beta-adrenergic receptor kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0008289	lipid binding
0.35	GO:0005080	protein kinase C binding

0.54	GO:0016607	nuclear speck
0.54	GO:0031965	nuclear membrane
0.48	GO:0005829	cytosol
0.43	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.85

EC:2.7.11.16

GO:0004703

sp|P34949|MPI_HUMAN
Mannose-6-phosphate isomerase
Search

MPI

0.57	Mannose phosphate isomerase

0.81	GO:0009298	GDP-mannose biosynthetic process
0.61	GO:0061611	mannose to fructose-6-phosphate metabolic process
0.48	GO:0000032	cell wall mannoprotein biosynthetic process
0.46	GO:0090171	chondrocyte morphogenesis
0.44	GO:0006486	protein glycosylation
0.44	GO:0001889	liver development
0.42	GO:0043009	chordate embryonic development
0.36	GO:0035434	copper ion transmembrane transport
0.36	GO:0061619	glycolytic process from mannose through fructose-6-phosphate
0.36	GO:0006402	mRNA catabolic process

0.80	GO:0004476	mannose-6-phosphate isomerase activity
0.63	GO:0008270	zinc ion binding
0.37	GO:0005375	copper ion transmembrane transporter activity
0.36	GO:0004654	polyribonucleotide nucleotidyltransferase activity
0.35	GO:0004930	G-protein coupled receptor activity
0.35	GO:0004222	metalloendopeptidase activity
0.34	GO:0003735	structural constituent of ribosome
0.34	GO:0003723	RNA binding

0.37	GO:0005737	cytoplasm
0.37	GO:0070062	extracellular exosome
0.34	GO:0030529	intracellular ribonucleoprotein complex
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane

0.80

EC:5.3.1.8

GO:0004476

sp|P34969|5HT7R_HUMAN
5-hydroxytryptamine receptor 7
Search

HTR7

0.91	Serotonin 5-hydroxytryptamine 7-a receptor

0.84	GO:0006939	smooth muscle contraction
0.83	GO:0042310	vasoconstriction
0.83	GO:0098664	G-protein coupled serotonin receptor signaling pathway
0.80	GO:0007623	circadian rhythm
0.76	GO:0007268	chemical synaptic transmission
0.46	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.37	GO:0007192	adenylate cyclase-activating serotonin receptor signaling pathway
0.36	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep
0.36	GO:0014063	negative regulation of serotonin secretion
0.36	GO:0051412	response to corticosterone

0.83	GO:0099589	serotonin receptor activity
0.80	GO:0099528	G-protein coupled neurotransmitter receptor activity
0.80	GO:0008227	G-protein coupled amine receptor activity
0.47	GO:0051378	serotonin binding

0.49	GO:0005887	integral component of plasma membrane
0.35	GO:0043679	axon terminus
0.35	GO:0005791	rough endoplasmic reticulum
0.35	GO:0008021	synaptic vesicle
0.35	GO:0043025	neuronal cell body
0.35	GO:0030425	dendrite

sp|P34972|CNR2_HUMAN
Cannabinoid receptor 2
Search

CNR2

0.94	Cannabinoid receptor

0.86	GO:0038171	cannabinoid signaling pathway
0.56	GO:0030595	leukocyte chemotaxis
0.45	GO:0007413	axonal fasciculation
0.44	GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
0.44	GO:0001889	liver development
0.44	GO:0050804	modulation of chemical synaptic transmission
0.43	GO:0099542	trans-synaptic signaling by endocannabinoid
0.42	GO:0097241	hematopoietic stem cell migration to bone marrow
0.41	GO:0060218	hematopoietic stem cell differentiation
0.41	GO:0045759	negative regulation of action potential

0.86	GO:0004949	cannabinoid receptor activity
0.35	GO:1904483	synthetic cannabinoid binding

0.44	GO:0005886	plasma membrane
0.44	GO:0043005	neuron projection
0.43	GO:0120038	plasma membrane bounded cell projection part
0.41	GO:0044297	cell body
0.40	GO:0030427	site of polarized growth
0.40	GO:0098793	presynapse
0.40	GO:0036477	somatodendritic compartment
0.38	GO:0098562	cytoplasmic side of membrane
0.38	GO:0019898	extrinsic component of membrane
0.35	GO:0005741	mitochondrial outer membrane

sp|P34981|TRFR_HUMAN
Thyrotropin-releasing hormone receptor
Search

TRHR

0.92	Thyrotropin-releasing hormone receptor b

0.69	GO:0007186	G-protein coupled receptor signaling pathway
0.35	GO:0090073	positive regulation of protein homodimerization activity
0.35	GO:0007204	positive regulation of cytosolic calcium ion concentration

0.85	GO:0004997	thyrotropin-releasing hormone receptor activity
0.34	GO:0042803	protein homodimerization activity

0.35	GO:0005886	plasma membrane
0.34	GO:0009986	cell surface
0.30	GO:0044425	membrane part

sp|P34982|OR1D2_HUMAN
Olfactory receptor 1D2
Search

0.44	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.38	GO:0000060	protein import into nucleus, translocation
0.35	GO:0007338	single fertilization
0.34	GO:0006935	chemotaxis
0.32	GO:0006518	peptide metabolic process
0.32	GO:0043604	amide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process
0.32	GO:1901566	organonitrogen compound biosynthetic process
0.32	GO:0010467	gene expression

0.76	GO:0004984	olfactory receptor activity
0.72	GO:0004930	G-protein coupled receptor activity
0.37	GO:0005549	odorant binding
0.36	GO:0042802	identical protein binding
0.32	GO:0003735	structural constituent of ribosome

0.55	GO:0005886	plasma membrane
0.33	GO:0005622	intracellular
0.32	GO:1990904	ribonucleoprotein complex
0.32	GO:0043228	non-membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

sp|P34995|PE2R1_HUMAN
Prostaglandin E2 receptor EP1 subtype
Search

PTGER1

0.97	Prostaglandin E receptor 1

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.66	GO:0032496	response to lipopolysaccharide
0.49	GO:0071798	response to prostaglandin D
0.47	GO:0071379	cellular response to prostaglandin stimulus
0.47	GO:0035584	calcium-mediated signaling using intracellular calcium source
0.46	GO:0032355	response to estradiol
0.44	GO:0008284	positive regulation of cell proliferation
0.44	GO:0043066	negative regulation of apoptotic process
0.42	GO:0010628	positive regulation of gene expression
0.34	GO:0007567	parturition

0.85	GO:0004955	prostaglandin receptor activity
0.52	GO:0004960	thromboxane receptor activity

0.41	GO:0005886	plasma membrane
0.41	GO:0005576	extracellular region
0.36	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|P34998|CRFR1_HUMAN
Corticotropin-releasing factor receptor 1
Search

CRHR1

0.92	Corticotrophin-releasing factor type 1 alpha receptor

0.71	GO:0007166	cell surface receptor signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.50	GO:0051458	corticotropin secretion
0.50	GO:2000852	regulation of corticosterone secretion
0.49	GO:0071376	cellular response to corticotropin-releasing hormone stimulus
0.47	GO:0019933	cAMP-mediated signaling
0.44	GO:0051867	general adaptation syndrome, behavioral process
0.42	GO:0030325	adrenal gland development
0.42	GO:0042596	fear response
0.42	GO:0048149	behavioral response to ethanol

0.72	GO:0004930	G-protein coupled receptor activity
0.41	GO:0043404	corticotropin-releasing hormone receptor activity
0.39	GO:0051424	corticotropin-releasing hormone binding
0.39	GO:0001965	G-protein alpha-subunit binding
0.37	GO:0032403	protein complex binding

0.48	GO:0005886	plasma membrane
0.41	GO:0005768	endosome
0.38	GO:0043025	neuronal cell body
0.38	GO:0030425	dendrite
0.38	GO:0045177	apical part of cell
0.38	GO:0005802	trans-Golgi network
0.36	GO:0044309	neuron spine
0.35	GO:0098794	postsynapse
0.30	GO:0016021	integral component of membrane

sp|P35030|TRY3_HUMAN
Trypsin-3
Search

0.46	Cationic trypsinogen

0.61	GO:0006508	proteolysis
0.53	GO:0007586	digestion
0.40	GO:0030574	collagen catabolic process
0.40	GO:0043542	endothelial cell migration
0.38	GO:0007584	response to nutrient
0.38	GO:0031000	response to caffeine
0.37	GO:0035094	response to nicotine
0.37	GO:0043312	neutrophil degranulation
0.37	GO:0019730	antimicrobial humoral response
0.37	GO:0022617	extracellular matrix disassembly

0.69	GO:0004252	serine-type endopeptidase activity
0.40	GO:0005509	calcium ion binding
0.35	GO:0005515	protein binding
0.33	GO:0004222	metalloendopeptidase activity

0.51	GO:0005615	extracellular space
0.38	GO:1903561	extracellular vesicle
0.36	GO:0030141	secretory granule
0.36	GO:0044433	cytoplasmic vesicle part
0.35	GO:0005766	primary lysosome
0.35	GO:0031983	vesicle lumen
0.35	GO:0070013	intracellular organelle lumen
0.34	GO:0044437	vacuolar part
0.34	GO:0031012	extracellular matrix
0.30	GO:0016020	membrane

0.69

GO:0004252

sp|P35052|GPC1_HUMAN
Glypican-1
Search

GPC1

0.97	Glypican-1 isoform B

0.70	GO:0009966	regulation of signal transduction
0.63	GO:2001016	positive regulation of skeletal muscle cell differentiation
0.57	GO:0030200	heparan sulfate proteoglycan catabolic process
0.53	GO:1902724	positive regulation of skeletal muscle satellite cell proliferation
0.52	GO:1902723	negative regulation of skeletal muscle satellite cell proliferation
0.52	GO:1902725	negative regulation of satellite cell differentiation
0.52	GO:0090288	negative regulation of cellular response to growth factor stimulus
0.48	GO:0023057	negative regulation of signaling
0.48	GO:0010648	negative regulation of cell communication
0.40	GO:0032288	myelin assembly

0.85	GO:0043395	heparan sulfate proteoglycan binding
0.54	GO:0017134	fibroblast growth factor binding
0.54	GO:0043236	laminin binding
0.48	GO:0005507	copper ion binding
0.37	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.36	GO:0070052	collagen V binding
0.35	GO:0033549	MAP kinase phosphatase activity

0.83	GO:0046658	anchored component of plasma membrane
0.76	GO:0005578	proteinaceous extracellular matrix
0.52	GO:0045121	membrane raft
0.48	GO:0005654	nucleoplasm
0.47	GO:0005829	cytosol
0.41	GO:0005615	extracellular space
0.39	GO:0005768	endosome
0.39	GO:0005796	Golgi lumen
0.37	GO:1903561	extracellular vesicle
0.36	GO:0043202	lysosomal lumen

0.37

EC:3.1.3

GO:0008138

sp|P35070|BTC_HUMAN
Probetacellulin
Search

BTC

0.97	Probetacellulin

0.50	GO:0008284	positive regulation of cell proliferation
0.50	GO:0007173	epidermal growth factor receptor signaling pathway
0.49	GO:0051781	positive regulation of cell division
0.48	GO:0035810	positive regulation of urine volume
0.47	GO:0043066	negative regulation of apoptotic process
0.46	GO:0048145	regulation of fibroblast proliferation
0.46	GO:0010469	regulation of receptor activity
0.46	GO:0045840	positive regulation of mitotic nuclear division
0.44	GO:0045597	positive regulation of cell differentiation
0.44	GO:0038128	ERBB2 signaling pathway

0.50	GO:0005154	epidermal growth factor receptor binding
0.47	GO:0008083	growth factor activity
0.43	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.40	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.40	GO:0004713	protein tyrosine kinase activity

0.45	GO:0005615	extracellular space
0.39	GO:0005886	plasma membrane
0.34	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

0.43	EC:2.7.1.153	GO:0046934
0.43	KEGG:R04545	GO:0046934

sp|P35080|PROF2_HUMAN
Profilin-2
Search

PFN2

0.69

Profilin

0.78	GO:0030833	regulation of actin filament polymerization
0.74	GO:0030036	actin cytoskeleton organization
0.56	GO:1900028	negative regulation of ruffle assembly
0.54	GO:2000300	regulation of synaptic vesicle exocytosis
0.54	GO:0032233	positive regulation of actin filament bundle assembly
0.53	GO:0010633	negative regulation of epithelial cell migration
0.53	GO:0033138	positive regulation of peptidyl-serine phosphorylation
0.53	GO:0051492	regulation of stress fiber assembly
0.51	GO:0032272	negative regulation of protein polymerization
0.51	GO:1902904	negative regulation of supramolecular fiber organization

0.74	GO:0003779	actin binding
0.52	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.42	GO:0016887	ATPase activity

0.53	GO:0043195	terminal bouton
0.38	GO:0005856	cytoskeleton
0.36	GO:0070062	extracellular exosome
0.36	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.42

GO:0016887

sp|P35125|UBP6_HUMAN
Ubiquitin carboxyl-terminal hydrolase 6
Search

USP32

0.67	Ubiquitin carboxyl-terminal hydrolase 6

0.74	GO:0016579	protein deubiquitination
0.70	GO:0006511	ubiquitin-dependent protein catabolic process
0.40	GO:0031338	regulation of vesicle fusion
0.40	GO:0090630	activation of GTPase activity
0.37	GO:0006886	intracellular protein transport
0.33	GO:0007165	signal transduction

0.75	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.65	GO:0005509	calcium ion binding
0.39	GO:0017137	Rab GTPase binding
0.38	GO:0005096	GTPase activator activity
0.36	GO:0005516	calmodulin binding
0.36	GO:0004197	cysteine-type endopeptidase activity
0.35	GO:0032266	phosphatidylinositol-3-phosphate binding
0.33	GO:0003676	nucleic acid binding

0.41	GO:0012505	endomembrane system
0.38	GO:0043227	membrane-bounded organelle
0.38	GO:0005829	cytosol
0.37	GO:0043229	intracellular organelle
0.35	GO:0005886	plasma membrane
0.34	GO:0045271	respiratory chain complex I
0.33	GO:1990204	oxidoreductase complex
0.32	GO:0031975	envelope
0.32	GO:0044422	organelle part

0.36

EC:3.4.22

GO:0004197

sp|P35212|CXA4_HUMAN
Gap junction alpha-4 protein
Search

GJA4

0.63	Gap junction protein alpha 4

0.60	GO:0007154	cell communication
0.56	GO:0001568	blood vessel development
0.48	GO:0098905	regulation of bundle of His cell action potential
0.48	GO:0098906	regulation of Purkinje myocyte action potential
0.48	GO:0098904	regulation of AV node cell action potential
0.48	GO:0003008	system process
0.48	GO:0003193	pulmonary valve formation
0.47	GO:0098910	regulation of atrial cardiac muscle cell action potential
0.47	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
0.47	GO:0016264	gap junction assembly

0.56	GO:0005243	gap junction channel activity
0.37	GO:0071253	connexin binding
0.37	GO:0097718	disordered domain specific binding

0.83	GO:0005922	connexin complex
0.45	GO:0014704	intercalated disc
0.41	GO:0005887	integral component of plasma membrane
0.35	GO:0042995	cell projection

sp|P35218|CAH5A_HUMAN
Carbonic anhydrase 5A, mitochondrial
Search

CA5A

0.97	Carbonic anhydrase VB, mitochondrial

0.72	GO:0006730	one-carbon metabolic process
0.40	GO:2000021	regulation of ion homeostasis
0.37	GO:0015701	bicarbonate transport
0.37	GO:0015670	carbon dioxide transport
0.37	GO:0097369	sodium ion import
0.37	GO:0042539	hypotonic salinity response
0.36	GO:0006885	regulation of pH
0.35	GO:0071466	cellular response to xenobiotic stimulus
0.34	GO:0019319	hexose biosynthetic process
0.34	GO:0006006	glucose metabolic process

0.78	GO:0004089	carbonate dehydratase activity
0.63	GO:0008270	zinc ion binding

0.58	GO:0005739	mitochondrion
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.78

GO:0004089

sp|P35219|CAH8_HUMAN
Carbonic anhydrase-related protein
Search

CA8

0.97	Carbonic anhydrase VIII

0.68	GO:0006730	one-carbon metabolic process
0.57	GO:0048015	phosphatidylinositol-mediated signaling
0.48	GO:0036269	swimming behavior
0.46	GO:0021549	cerebellum development
0.45	GO:0043009	chordate embryonic development

0.74	GO:0004089	carbonate dehydratase activity
0.60	GO:0008270	zinc ion binding
0.35	GO:0005515	protein binding

0.40	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.74

GO:0004089

sp|P35221|CTNA1_HUMAN
Catenin alpha-1
Search

CTNNA1

0.92	LOW QUALITY PROTEIN: catenin alpha-1

0.85	GO:0090136	epithelial cell-cell adhesion
0.73	GO:0007015	actin filament organization
0.58	GO:0071681	cellular response to indole-3-methanol
0.58	GO:2001045	negative regulation of integrin-mediated signaling pathway
0.56	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
0.56	GO:0007406	negative regulation of neuroblast proliferation
0.55	GO:1901099	negative regulation of signal transduction in absence of ligand
0.55	GO:0045880	positive regulation of smoothened signaling pathway
0.54	GO:0043297	apical junction assembly
0.54	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

0.82	GO:0045296	cadherin binding
0.81	GO:0008013	beta-catenin binding
0.78	GO:0051015	actin filament binding
0.59	GO:0005198	structural molecule activity
0.58	GO:0045295	gamma-catenin binding
0.57	GO:0017166	vinculin binding
0.51	GO:0042802	identical protein binding
0.49	GO:0046982	protein heterodimerization activity
0.34	GO:0003723	RNA binding

0.80	GO:0005912	adherens junction
0.70	GO:0015629	actin cytoskeleton
0.67	GO:0005829	cytosol
0.61	GO:0016342	catenin complex
0.58	GO:0005911	cell-cell junction
0.56	GO:0016600	flotillin complex
0.54	GO:0030027	lamellipodium
0.49	GO:0005794	Golgi apparatus
0.45	GO:0005902	microvillus
0.43	GO:0005938	cell cortex

sp|P35222|CTNB1_HUMAN
Catenin beta-1
Search

CTNNB1

0.95	Catenin (Cadherin-associated protein) beta 1

0.85	GO:0034333	adherens junction assembly
0.61	GO:0007165	signal transduction
0.57	GO:0070602	regulation of centromeric sister chromatid cohesion
0.56	GO:1904499	regulation of chromatin-mediated maintenance of transcription
0.56	GO:1904793	regulation of euchromatin binding
0.56	GO:0072054	renal outer medulla development
0.56	GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process
0.56	GO:0072053	renal inner medulla development
0.56	GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
0.56	GO:0030997	regulation of centriole-centriole cohesion

0.64	GO:0004871	signal transducer activity
0.57	GO:0045294	alpha-catenin binding
0.55	GO:0045296	cadherin binding
0.55	GO:0019903	protein phosphatase binding
0.54	GO:0070411	I-SMAD binding
0.53	GO:0030331	estrogen receptor binding
0.53	GO:0001105	RNA polymerase II transcription coactivator activity
0.53	GO:0097718	disordered domain specific binding
0.53	GO:0001102	RNA polymerase II activating transcription factor binding
0.52	GO:0070491	repressing transcription factor binding

0.58	GO:0016342	catenin complex
0.56	GO:0070369	beta-catenin-TCF7L2 complex
0.56	GO:0034750	Scrib-APC-beta-catenin complex
0.55	GO:1990909	Wnt signalosome
0.54	GO:0014704	intercalated disc
0.54	GO:0030877	beta-catenin destruction complex
0.54	GO:0016600	flotillin complex
0.54	GO:0031528	microvillus membrane
0.54	GO:0005913	cell-cell adherens junction
0.53	GO:0016328	lateral plasma membrane

sp|P35225|IL13_HUMAN
Interleukin-13
Search

IL13

0.97	Interleukin 13 (Predicted)

0.74	GO:0006955	immune response
0.68	GO:1903660	negative regulation of complement-dependent cytotoxicity
0.65	GO:2000352	negative regulation of endothelial cell apoptotic process
0.64	GO:0043306	positive regulation of mast cell degranulation
0.63	GO:0043032	positive regulation of macrophage activation
0.62	GO:0002639	positive regulation of immunoglobulin production
0.58	GO:0006954	inflammatory response
0.57	GO:0071345	cellular response to cytokine stimulus
0.49	GO:0010469	regulation of receptor activity
0.43	GO:0032723	positive regulation of connective tissue growth factor production

0.79	GO:0005126	cytokine receptor binding
0.51	GO:0005125	cytokine activity
0.34	GO:0016887	ATPase activity
0.34	GO:0046872	metal ion binding

0.66	GO:0005576	extracellular region
0.59	GO:0009897	external side of plasma membrane
0.41	GO:0005737	cytoplasm
0.38	GO:0030870	Mre11 complex
0.30	GO:0016021	integral component of membrane

0.34

GO:0016887

sp|P35226|BMI1_HUMAN
Polycomb complex protein BMI-1
Search

BMI1

0.95	Polycomb group RING finger protein 4

0.82	GO:0033092	positive regulation of immature T cell proliferation in thymus
0.81	GO:2000011	regulation of adaxial/abaxial pattern formation
0.81	GO:0016574	histone ubiquitination
0.80	GO:0048704	embryonic skeletal system morphogenesis
0.79	GO:2001234	negative regulation of apoptotic signaling pathway
0.78	GO:0009952	anterior/posterior pattern specification
0.77	GO:0030890	positive regulation of B cell proliferation
0.76	GO:0048103	somatic stem cell division
0.76	GO:0021532	neural tube patterning
0.75	GO:0000122	negative regulation of transcription by RNA polymerase II

0.79	GO:1990841	promoter-specific chromatin binding
0.74	GO:0097027	ubiquitin-protein transferase activator activity
0.71	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.46	GO:0071535	RING-like zinc finger domain binding
0.42	GO:0008270	zinc ion binding
0.34	GO:0003700	DNA binding transcription factor activity

0.82	GO:0031519	PcG protein complex
0.78	GO:0000792	heterochromatin
0.76	GO:0016604	nuclear body
0.74	GO:0000151	ubiquitin ligase complex
0.57	GO:0000803	sex chromosome
0.51	GO:0000790	nuclear chromatin
0.39	GO:0005829	cytosol

sp|P35227|PCGF2_HUMAN
Polycomb group RING finger protein 2
Search

PCGF2

0.91	Polycomb group RING finger protein 2

0.82	GO:0016574	histone ubiquitination
0.81	GO:0048704	embryonic skeletal system morphogenesis
0.80	GO:2001234	negative regulation of apoptotic signaling pathway
0.79	GO:0009952	anterior/posterior pattern specification
0.77	GO:0001701	in utero embryonic development
0.76	GO:0000122	negative regulation of transcription by RNA polymerase II
0.76	GO:0016573	histone acetylation
0.72	GO:0006513	protein monoubiquitination
0.71	GO:0070301	cellular response to hydrogen peroxide
0.69	GO:0033092	positive regulation of immature T cell proliferation in thymus

0.76	GO:0003682	chromatin binding
0.64	GO:0097027	ubiquitin-protein transferase activator activity
0.61	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.42	GO:0071535	RING-like zinc finger domain binding
0.40	GO:0046872	metal ion binding
0.35	GO:0003700	DNA binding transcription factor activity

0.82	GO:0031519	PcG protein complex
0.80	GO:0000792	heterochromatin
0.76	GO:0016604	nuclear body
0.74	GO:0000151	ubiquitin ligase complex
0.72	GO:0000803	sex chromosome
0.63	GO:0000790	nuclear chromatin
0.36	GO:0005829	cytosol

sp|P35228|NOS2_HUMAN
Nitric oxide synthase, inducible
Search

NOS2

0.72	Nitric oxide synthase

0.83	GO:0006809	nitric oxide biosynthetic process
0.62	GO:0072604	interleukin-6 secretion
0.62	GO:0032310	prostaglandin secretion
0.62	GO:0072606	interleukin-8 secretion
0.61	GO:0018119	peptidyl-cysteine S-nitrosylation
0.60	GO:1900015	regulation of cytokine production involved in inflammatory response
0.57	GO:0009617	response to bacterium
0.56	GO:0071346	cellular response to interferon-gamma
0.56	GO:0050796	regulation of insulin secretion
0.55	GO:0098542	defense response to other organism

0.84	GO:0004517	nitric-oxide synthase activity
0.78	GO:0005516	calmodulin binding
0.69	GO:0010181	FMN binding
0.68	GO:0050661	NADP binding
0.64	GO:0050660	flavin adenine dinucleotide binding
0.62	GO:0020037	heme binding
0.61	GO:0005506	iron ion binding
0.60	GO:0034617	tetrahydrobiopterin binding
0.54	GO:0034618	arginine binding
0.51	GO:0042803	protein homodimerization activity

0.54	GO:0030863	cortical cytoskeleton
0.53	GO:0048471	perinuclear region of cytoplasm
0.52	GO:0005777	peroxisome
0.48	GO:0005829	cytosol
0.34	GO:0005634	nucleus
0.34	GO:0012506	vesicle membrane
0.34	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane

0.84

EC:1.14.13.39

GO:0004517

sp|P35232|PHB_HUMAN
Prohibitin
Search

PHB

0.84	Mitochondrial prohibitin

0.55	GO:0045917	positive regulation of complement activation
0.54	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway
0.54	GO:0050847	progesterone receptor signaling pathway
0.54	GO:0010944	negative regulation of transcription by competitive promoter binding
0.54	GO:0060766	negative regulation of androgen receptor signaling pathway
0.53	GO:0071354	cellular response to interleukin-6
0.53	GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
0.52	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.51	GO:0042177	negative regulation of protein catabolic process
0.51	GO:0030308	negative regulation of cell growth

0.56	GO:0001850	complement component C3a binding
0.56	GO:0001851	complement component C3b binding
0.55	GO:0031871	proteinase activated receptor binding
0.52	GO:0042826	histone deacetylase binding
0.51	GO:0008022	protein C-terminus binding
0.48	GO:0044212	transcription regulatory region DNA binding
0.47	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding

0.50	GO:0043209	myelin sheath
0.50	GO:0005769	early endosome
0.50	GO:0009986	cell surface
0.46	GO:0005654	nucleoplasm
0.44	GO:0005887	integral component of plasma membrane
0.44	GO:0031966	mitochondrial membrane
0.44	GO:0019866	organelle inner membrane
0.36	GO:0070062	extracellular exosome
0.36	GO:0031312	extrinsic component of organelle membrane
0.36	GO:0031968	organelle outer membrane

sp|P35236|PTN7_HUMAN
Tyrosine-protein phosphatase non-receptor type 7
Search

PTPN7

0.97	LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7

0.73	GO:0035335	peptidyl-tyrosine dephosphorylation
0.40	GO:0038128	ERBB2 signaling pathway
0.39	GO:0010633	negative regulation of epithelial cell migration
0.39	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.36	GO:0071345	cellular response to cytokine stimulus

0.74	GO:0004725	protein tyrosine phosphatase activity
0.46	GO:0001784	phosphotyrosine residue binding
0.37	GO:0019901	protein kinase binding
0.34	GO:0008138	protein tyrosine/serine/threonine phosphatase activity

0.52	GO:0009898	cytoplasmic side of plasma membrane
0.50	GO:0005829	cytosol
0.38	GO:0030054	cell junction
0.37	GO:0005856	cytoskeleton
0.35	GO:0005654	nucleoplasm
0.33	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

0.74

GO:0004725

sp|P35237|SPB6_HUMAN
Serpin B6
Search

0.97	Serpin peptidase inhibitor, clade B (Ovalbumin), member 6

0.60	GO:0010951	negative regulation of endopeptidase activity
0.49	GO:0090136	epithelial cell-cell adhesion
0.48	GO:0042270	protection from natural killer cell mediated cytotoxicity
0.46	GO:0002444	myeloid leukocyte mediated immunity
0.46	GO:0052490	negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction
0.46	GO:0071391	cellular response to estrogen stimulus
0.44	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.43	GO:0043066	negative regulation of apoptotic process
0.43	GO:0052150	modulation by symbiont of host apoptotic process
0.43	GO:0006915	apoptotic process

0.62	GO:0004867	serine-type endopeptidase inhibitor activity
0.47	GO:0002020	protease binding
0.46	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.33	GO:0004601	peroxidase activity

0.73	GO:0005615	extracellular space
0.47	GO:0005829	cytosol
0.42	GO:0005794	Golgi apparatus
0.41	GO:0005654	nucleoplasm
0.39	GO:0097180	serine protease inhibitor complex
0.38	GO:1903561	extracellular vesicle
0.36	GO:0101003	ficolin-1-rich granule membrane
0.36	GO:0070821	tertiary granule membrane
0.33	GO:0031012	extracellular matrix
0.33	GO:0005886	plasma membrane

0.33	EC:1.11.1.7	GO:0004601
0.33	KEGG:R03532	GO:0004601

sp|P35240|MERL_HUMAN
Merlin
Search

NF2

0.91	Neurofibromin 2

0.67	GO:0014010	Schwann cell proliferation
0.64	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein
0.64	GO:0007398	ectoderm development
0.63	GO:0035330	regulation of hippo signaling
0.63	GO:0070306	lens fiber cell differentiation
0.62	GO:0051496	positive regulation of stress fiber assembly
0.62	GO:0021766	hippocampus development
0.62	GO:0001707	mesoderm formation
0.62	GO:0072091	regulation of stem cell proliferation
0.62	GO:0014013	regulation of gliogenesis

0.73

GO:0003779

actin binding

0.69	GO:0005856	cytoskeleton
0.62	GO:0032154	cleavage furrow
0.61	GO:0030175	filopodium
0.60	GO:0001726	ruffle
0.60	GO:0030027	lamellipodium
0.59	GO:0044297	cell body
0.59	GO:0045177	apical part of cell
0.59	GO:0005769	early endosome
0.58	GO:0005912	adherens junction
0.58	GO:0048471	perinuclear region of cytoplasm

sp|P35241|RADI_HUMAN
Radixin
Search

RDX

0.97	Radixin isoform C

0.58	GO:1902966	positive regulation of protein localization to early endosome
0.58	GO:2000643	positive regulation of early endosome to late endosome transport
0.57	GO:0034111	negative regulation of homotypic cell-cell adhesion
0.57	GO:0045792	negative regulation of cell size
0.56	GO:1903392	negative regulation of adherens junction organization
0.56	GO:1900027	regulation of ruffle assembly
0.56	GO:0061028	establishment of endothelial barrier
0.56	GO:0034260	negative regulation of GTPase activity
0.56	GO:0030033	microvillus assembly
0.55	GO:0097067	cellular response to thyroid hormone stimulus

0.72	GO:0003779	actin binding
0.55	GO:0051117	ATPase binding
0.53	GO:0045296	cadherin binding
0.50	GO:0019904	protein domain specific binding
0.49	GO:0042803	protein homodimerization activity
0.36	GO:0051018	protein kinase A binding
0.35	GO:0003723	RNA binding

0.69	GO:0005856	cytoskeleton
0.54	GO:0005902	microvillus
0.54	GO:0032420	stereocilium
0.53	GO:0005925	focal adhesion
0.53	GO:0016324	apical plasma membrane
0.53	GO:0030175	filopodium
0.52	GO:0001726	ruffle
0.52	GO:0030027	lamellipodium
0.52	GO:0043209	myelin sheath
0.50	GO:0044448	cell cortex part

sp|P35243|RECO_HUMAN
Recoverin
Search

RCVRN

0.97	Recoverin a

0.56	GO:0009416	response to light stimulus
0.52	GO:0051924	regulation of calcium ion transport
0.51	GO:0007601	visual perception
0.50	GO:0009582	detection of abiotic stimulus
0.50	GO:0009581	detection of external stimulus
0.43	GO:0007165	signal transduction
0.35	GO:0031284	positive regulation of guanylate cyclase activity
0.33	GO:1904063	negative regulation of cation transmembrane transport
0.33	GO:0032845	negative regulation of homeostatic process
0.33	GO:2000021	regulation of ion homeostasis

0.70	GO:0005509	calcium ion binding
0.36	GO:0008048	calcium sensitive guanylate cyclase activator activity
0.34	GO:0098744	1-phosphatidylinositol 4-kinase activator activity
0.33	GO:0005515	protein binding
0.32	GO:0008236	serine-type peptidase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.32	GO:0003677	DNA binding

0.39	GO:0030425	dendrite
0.33	GO:0005829	cytosol
0.33	GO:0000139	Golgi membrane
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P35244|RFA3_HUMAN
Replication protein A 14 kDa subunit
Search

RPA3

0.66	Replication protein A subunit

0.66	GO:0006260	DNA replication
0.65	GO:0006310	DNA recombination
0.65	GO:0006281	DNA repair
0.51	GO:0042127	regulation of cell proliferation
0.51	GO:0007346	regulation of mitotic cell cycle
0.37	GO:0042769	DNA damage response, detection of DNA damage
0.37	GO:1900034	regulation of cellular response to heat
0.37	GO:1901796	regulation of signal transduction by p53 class mediator
0.36	GO:0000082	G1/S transition of mitotic cell cycle
0.36	GO:0031334	positive regulation of protein complex assembly

0.55	GO:0003677	DNA binding
0.34	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.52	GO:0030894	replisome
0.49	GO:0031974	membrane-enclosed lumen
0.45	GO:0043234	protein complex

sp|P35247|SFTPD_HUMAN
Pulmonary surfactant-associated protein D
Search

SFTPD

0.97	Pulmonary surfactant-associated protein D

0.67	GO:1905226	regulation of adhesion of symbiont to host epithelial cell
0.65	GO:0043129	surfactant homeostasis
0.64	GO:0043152	induction of bacterial agglutination
0.64	GO:0052405	negative regulation by host of symbiont molecular function
0.63	GO:0048286	lung alveolus development
0.48	GO:0007585	respiratory gaseous exchange
0.46	GO:0045087	innate immune response
0.41	GO:0032703	negative regulation of interleukin-2 production
0.41	GO:0050766	positive regulation of phagocytosis
0.41	GO:0042130	negative regulation of T cell proliferation

0.45	GO:0042802	identical protein binding
0.45	GO:0030246	carbohydrate binding
0.42	GO:0005201	extracellular matrix structural constituent
0.40	GO:0004867	serine-type endopeptidase inhibitor activity
0.37	GO:0001530	lipopolysaccharide binding
0.35	GO:0036094	small molecule binding
0.33	GO:0042302	structural constituent of cuticle
0.33	GO:0004713	protein tyrosine kinase activity
0.32	GO:0005509	calcium ion binding
0.32	GO:0004674	protein serine/threonine kinase activity

0.77	GO:0005581	collagen trimer
0.48	GO:0005578	proteinaceous extracellular matrix
0.44	GO:0005615	extracellular space
0.41	GO:0044420	extracellular matrix component
0.39	GO:0042599	lamellar body
0.38	GO:0045334	clathrin-coated endocytic vesicle
0.38	GO:0005783	endoplasmic reticulum
0.37	GO:0005771	multivesicular body
0.37	GO:0005764	lysosome
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network

0.33

GO:0004713

sp|P35249|RFC4_HUMAN
Replication factor C subunit 4
Search

RFC4

0.85	Replication factor C subunit 4

0.63	GO:0006260	DNA replication
0.59	GO:1900264	positive regulation of DNA-directed DNA polymerase activity
0.45	GO:0060041	retina development in camera-type eye
0.41	GO:0006281	DNA repair
0.36	GO:0042769	DNA damage response, detection of DNA damage
0.36	GO:1901796	regulation of signal transduction by p53 class mediator
0.35	GO:0022616	DNA strand elongation
0.35	GO:0000723	telomere maintenance
0.34	GO:0022402	cell cycle process
0.34	GO:0019725	cellular homeostasis

0.57	GO:0003689	DNA clamp loader activity
0.56	GO:0043142	single-stranded DNA-dependent ATPase activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0019899	enzyme binding

0.57	GO:0005663	DNA replication factor C complex
0.56	GO:0031390	Ctf18 RFC-like complex
0.49	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

sp|P35250|RFC2_HUMAN
Replication factor C subunit 2
Search

RFC2

0.87	Replication factor C subunit 2

0.66	GO:0006260	DNA replication
0.55	GO:1900264	positive regulation of DNA-directed DNA polymerase activity
0.42	GO:0006281	DNA repair
0.35	GO:0042769	DNA damage response, detection of DNA damage
0.35	GO:1901796	regulation of signal transduction by p53 class mediator
0.34	GO:0000723	telomere maintenance
0.34	GO:0022402	cell cycle process
0.33	GO:0019725	cellular homeostasis
0.33	GO:0071897	DNA biosynthetic process
0.33	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.57	GO:0003689	DNA clamp loader activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0043142	single-stranded DNA-dependent ATPase activity
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0019899	enzyme binding

0.56	GO:0005663	DNA replication factor C complex
0.53	GO:0031390	Ctf18 RFC-like complex
0.41	GO:0005634	nucleus
0.35	GO:0031974	membrane-enclosed lumen

sp|P35251|RFC1_HUMAN
Replication factor C subunit 1
Search

RFC1

0.69	Replication factor C subunit 1

0.66	GO:0006260	DNA replication
0.65	GO:0006281	DNA repair
0.41	GO:0000122	negative regulation of transcription by RNA polymerase II
0.40	GO:0045893	positive regulation of transcription, DNA-templated
0.34	GO:0006351	transcription, DNA-templated
0.30	GO:0051276	chromosome organization
0.30	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.30	GO:0060249	anatomical structure homeostasis
0.30	GO:0006278	RNA-dependent DNA biosynthetic process
0.30	GO:0022402	cell cycle process

0.84	GO:0003689	DNA clamp loader activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0019904	protein domain specific binding
0.39	GO:0003690	double-stranded DNA binding
0.38	GO:0043565	sequence-specific DNA binding
0.30	GO:0098772	molecular function regulator

0.84	GO:0005663	DNA replication factor C complex
0.59	GO:0005634	nucleus
0.47	GO:0031974	membrane-enclosed lumen
0.39	GO:0070062	extracellular exosome
0.34	GO:0005737	cytoplasm

sp|P35268|RL22_HUMAN
60S ribosomal protein L22
Search

RPL22

0.59	Chromodomain helicase DNA binding protein 5

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.47	GO:0030217	T cell differentiation
0.44	GO:0046631	alpha-beta T cell activation
0.34	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.34	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.34	GO:0019083	viral transcription
0.33	GO:0016072	rRNA metabolic process

0.64	GO:0003735	structural constituent of ribosome
0.45	GO:0008201	heparin binding
0.41	GO:0003723	RNA binding
0.33	GO:0005515	protein binding

0.61	GO:0005840	ribosome
0.43	GO:0044445	cytosolic part
0.39	GO:0044446	intracellular organelle part
0.38	GO:0005634	nucleus
0.36	GO:0031012	extracellular matrix
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.34	GO:0005791	rough endoplasmic reticulum
0.34	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0098562	cytoplasmic side of membrane

sp|P35269|T2FA_HUMAN
General transcription factor IIF subunit 1
Search

GTF2F1

0.94	Transcription initiation factor IIF alpha subunit

0.80	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
0.78	GO:0006367	transcription initiation from RNA polymerase II promoter
0.48	GO:0009615	response to virus
0.47	GO:0043085	positive regulation of catalytic activity
0.38	GO:0006413	translational initiation
0.35	GO:0010469	regulation of receptor activity
0.32	GO:0042795	snRNA transcription by RNA polymerase II
0.32	GO:0008543	fibroblast growth factor receptor signaling pathway
0.32	GO:0006368	transcription elongation from RNA polymerase II promoter
0.32	GO:0050434	positive regulation of viral transcription

0.54	GO:0003677	DNA binding
0.52	GO:0019211	phosphatase activator activity
0.51	GO:0019903	protein phosphatase binding
0.48	GO:0019904	protein domain specific binding
0.47	GO:0008134	transcription factor binding
0.38	GO:0003743	translation initiation factor activity
0.35	GO:0008083	growth factor activity
0.33	GO:0016740	transferase activity
0.32	GO:0003713	transcription coactivator activity

0.60	GO:0005634	nucleus
0.48	GO:0000428	DNA-directed RNA polymerase complex
0.48	GO:0005667	transcription factor complex
0.48	GO:0030054	cell junction
0.45	GO:0031974	membrane-enclosed lumen
0.41	GO:0044446	intracellular organelle part
0.34	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0016740

sp|P35270|SPRE_HUMAN
Sepiapterin reductase
Search

SPR

0.85	Sepiapterin reductase a

0.76	GO:0046146	tetrahydrobiopterin metabolic process
0.76	GO:0034312	diol biosynthetic process
0.69	GO:0042559	pteridine-containing compound biosynthetic process
0.62	GO:0009108	coenzyme biosynthetic process
0.56	GO:0006809	nitric oxide biosynthetic process
0.51	GO:0055114	oxidation-reduction process
0.38	GO:0019889	pteridine metabolic process
0.38	GO:0050882	voluntary musculoskeletal movement
0.38	GO:0042415	norepinephrine metabolic process
0.38	GO:0042428	serotonin metabolic process

0.85	GO:0004757	sepiapterin reductase activity
0.36	GO:0102306	benzil reductase [(S)-benzoin-forming] activity
0.36	GO:0004033	aldo-keto reductase (NADP) activity
0.36	GO:0042803	protein homodimerization activity
0.34	GO:0050661	NADP binding

0.49	GO:0005654	nucleoplasm
0.48	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.34	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.85

EC:1.1.1.153

GO:0004757

sp|P35318|ADML_HUMAN
ADM
Search

ADM

0.97	Adrenomedullin a

0.76	GO:0010469	regulation of receptor activity
0.68	GO:1990410	adrenomedullin receptor signaling pathway
0.68	GO:0097647	amylin receptor signaling pathway
0.67	GO:0045906	negative regulation of vasoconstriction
0.67	GO:0002031	G-protein coupled receptor internalization
0.66	GO:0035809	regulation of urine volume
0.66	GO:2001214	positive regulation of vasculogenesis
0.66	GO:0097084	vascular smooth muscle cell development
0.66	GO:0010460	positive regulation of heart rate
0.65	GO:0043116	negative regulation of vascular permeability

0.79	GO:0005179	hormone activity
0.70	GO:0031700	adrenomedullin receptor binding

0.66	GO:0005576	extracellular region
0.41	GO:0005737	cytoplasm

sp|P35321|SPR1A_HUMAN
Cornifin-A
Search

0.94	Small proline rich protein 3

0.83	GO:0018149	peptide cross-linking
0.63	GO:0030216	keratinocyte differentiation
0.40	GO:0012501	programmed cell death
0.34	GO:0007010	cytoskeleton organization
0.34	GO:0008360	regulation of cell shape
0.34	GO:0030001	metal ion transport
0.34	GO:0042060	wound healing

0.49	GO:0030280	structural constituent of epidermis
0.49	GO:0030674	protein binding, bridging
0.35	GO:0005200	structural constituent of cytoskeleton
0.33	GO:0046872	metal ion binding

0.65	GO:0001533	cornified envelope
0.48	GO:0005737	cytoplasm
0.40	GO:0012505	endomembrane system
0.39	GO:0070062	extracellular exosome
0.37	GO:0043231	intracellular membrane-bounded organelle

sp|P35325|SPR2B_HUMAN
Small proline-rich protein 2B
Search

0.97	Small proline-rich protein 2B

0.61	GO:0018149	peptide cross-linking
0.58	GO:0030216	keratinocyte differentiation
0.45	GO:0032355	response to estradiol
0.41	GO:0012501	programmed cell death
0.37	GO:0008585	female gonad development
0.35	GO:0009411	response to UV
0.34	GO:0051258	protein polymerization
0.34	GO:0009664	plant-type cell wall organization
0.33	GO:0051128	regulation of cellular component organization
0.33	GO:0040008	regulation of growth

0.46	GO:0005198	structural molecule activity
0.38	GO:0030674	protein binding, bridging
0.34	GO:0046983	protein dimerization activity
0.33	GO:0005520	insulin-like growth factor binding
0.33	GO:0046872	metal ion binding
0.32	GO:0003676	nucleic acid binding
0.32	GO:0003700	DNA binding transcription factor activity

0.81	GO:0001533	cornified envelope
0.42	GO:0005737	cytoplasm
0.38	GO:0005634	nucleus
0.34	GO:0005576	extracellular region
0.33	GO:0009505	plant-type cell wall
0.33	GO:0055044	symplast
0.33	GO:0031982	vesicle
0.33	GO:0005911	cell-cell junction
0.33	GO:0012505	endomembrane system
0.30	GO:0016021	integral component of membrane

sp|P35326|SPR2A_HUMAN
Small proline-rich protein 2A
Search

0.97	Small proline-rich protein 2A

0.62	GO:0018149	peptide cross-linking
0.58	GO:0008544	epidermis development
0.56	GO:0043588	skin development
0.54	GO:0030855	epithelial cell differentiation
0.43	GO:0032355	response to estradiol
0.40	GO:0012501	programmed cell death
0.36	GO:0008585	female gonad development
0.34	GO:0009664	plant-type cell wall organization
0.34	GO:0009411	response to UV
0.34	GO:0051258	protein polymerization

0.46	GO:0005198	structural molecule activity
0.37	GO:0030674	protein binding, bridging
0.33	GO:0046983	protein dimerization activity
0.33	GO:0005520	insulin-like growth factor binding
0.33	GO:0046872	metal ion binding
0.32	GO:0042802	identical protein binding
0.32	GO:0003676	nucleic acid binding
0.32	GO:0003700	DNA binding transcription factor activity

0.76	GO:0001533	cornified envelope
0.42	GO:0005737	cytoplasm
0.37	GO:0005634	nucleus
0.35	GO:0005576	extracellular region
0.34	GO:0031982	vesicle
0.34	GO:0012505	endomembrane system
0.33	GO:0009505	plant-type cell wall
0.33	GO:0055044	symplast
0.32	GO:0005911	cell-cell junction
0.30	GO:0016021	integral component of membrane

sp|P35346|SSR5_HUMAN
Somatostatin receptor type 5
Search

SSTR5

0.97	Somatostatin receptor subtype 5

0.86	GO:0038170	somatostatin signaling pathway
0.54	GO:0090276	regulation of peptide hormone secretion
0.54	GO:0032467	positive regulation of cytokinesis
0.52	GO:0050708	regulation of protein secretion
0.51	GO:0042593	glucose homeostasis
0.49	GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
0.48	GO:0071385	cellular response to glucocorticoid stimulus
0.48	GO:0007268	chemical synaptic transmission
0.45	GO:0008285	negative regulation of cell proliferation
0.42	GO:0007218	neuropeptide signaling pathway

0.86	GO:0004994	somatostatin receptor activity
0.52	GO:0042923	neuropeptide binding
0.43	GO:0005102	receptor binding

0.49	GO:0120025	plasma membrane bounded cell projection
0.47	GO:0097458	neuron part
0.45	GO:0098590	plasma membrane region
0.44	GO:0005887	integral component of plasma membrane
0.43	GO:0098588	bounding membrane of organelle
0.43	GO:0044463	cell projection part
0.33	GO:0005737	cytoplasm

sp|P35348|ADA1A_HUMAN
Alpha-1A adrenergic receptor
Search

ADRA1A

0.95	Alpha-1a adrenoceptor transcript variant 1

0.85	GO:0071875	adrenergic receptor signaling pathway
0.80	GO:0055117	regulation of cardiac muscle contraction
0.80	GO:0019229	regulation of vasoconstriction
0.70	GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
0.67	GO:0045987	positive regulation of smooth muscle contraction
0.66	GO:1903524	positive regulation of blood circulation
0.65	GO:0001985	negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
0.65	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
0.64	GO:1903995	regulation of non-membrane spanning protein tyrosine kinase activity
0.63	GO:0003057	regulation of the force of heart contraction by chemical signal

0.85	GO:0004935	adrenergic receptor activity
0.59	GO:0046982	protein heterodimerization activity

0.62	GO:0031965	nuclear membrane
0.56	GO:0005886	plasma membrane
0.42	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|P35354|PGH2_HUMAN
Prostaglandin G/H synthase 2
Search

PTGS2

0.96	Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)

0.86	GO:0019371	cyclooxygenase pathway
0.82	GO:0008217	regulation of blood pressure
0.80	GO:0006954	inflammatory response
0.71	GO:0006979	response to oxidative stress
0.69	GO:0098869	cellular oxidant detoxification
0.59	GO:0071471	cellular response to non-ionic osmotic stress
0.59	GO:0031394	positive regulation of prostaglandin biosynthetic process
0.58	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
0.58	GO:0031622	positive regulation of fever generation
0.57	GO:0090336	positive regulation of brown fat cell differentiation

0.86	GO:0004666	prostaglandin-endoperoxide synthase activity
0.72	GO:0004601	peroxidase activity
0.63	GO:0020037	heme binding
0.50	GO:0042803	protein homodimerization activity
0.49	GO:0019899	enzyme binding
0.40	GO:0051213	dioxygenase activity
0.36	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
0.36	GO:0046872	metal ion binding

0.52	GO:0043005	neuron projection
0.50	GO:0005783	endoplasmic reticulum
0.40	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.39	GO:0031984	organelle subcompartment
0.38	GO:0031090	organelle membrane
0.38	GO:0005901	caveola
0.34	GO:0043234	protein complex
0.33	GO:0070013	intracellular organelle lumen
0.33	GO:0005634	nucleus

0.86	EC:1.14.99.1	GO:0004666
0.72	KEGG:R03532	GO:0004601

sp|P35367|HRH1_HUMAN
Histamine H1 receptor
Search

HRH1

0.97	Histamine H1 receptor

0.85	GO:0048245	eosinophil chemotaxis
0.85	GO:0043114	regulation of vascular permeability
0.85	GO:0045907	positive regulation of vasoconstriction
0.69	GO:0007186	G-protein coupled receptor signaling pathway
0.61	GO:0050804	modulation of chemical synaptic transmission
0.61	GO:0008542	visual learning
0.59	GO:0007613	memory
0.49	GO:0071420	cellular response to histamine
0.49	GO:0006954	inflammatory response
0.40	GO:0032962	positive regulation of inositol trisphosphate biosynthetic process

0.85	GO:0004969	histamine receptor activity
0.37	GO:0015085	calcium ion transmembrane transporter activity
0.37	GO:0051381	histamine binding
0.35	GO:0016907	G-protein coupled acetylcholine receptor activity

0.52	GO:0005829	cytosol
0.46	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P35368|ADA1B_HUMAN
Alpha-1B adrenergic receptor
Search

ADRA1B

0.97	Alpha-1B adrenergic receptor

0.85	GO:0071875	adrenergic receptor signaling pathway
0.83	GO:0055117	regulation of cardiac muscle contraction
0.82	GO:0019229	regulation of vasoconstriction
0.55	GO:0043410	positive regulation of MAPK cascade
0.52	GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
0.50	GO:0045987	positive regulation of smooth muscle contraction
0.49	GO:1903524	positive regulation of blood circulation
0.49	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
0.49	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.48	GO:0007204	positive regulation of cytosolic calcium ion concentration

0.86	GO:0004937	alpha1-adrenergic receptor activity
0.53	GO:0046982	protein heterodimerization activity

0.55	GO:0031965	nuclear membrane
0.55	GO:0005886	plasma membrane
0.40	GO:0045121	membrane raft
0.40	GO:0005737	cytoplasm
0.35	GO:0014704	intercalated disc
0.30	GO:0016021	integral component of membrane

sp|P35372|OPRM_HUMAN
Mu-type opioid receptor
Search

OPRM1

0.97	Mu opioid receptor variant

0.85	GO:0038003	opioid receptor signaling pathway
0.79	GO:0007218	neuropeptide signaling pathway
0.60	GO:0061358	negative regulation of Wnt protein secretion
0.57	GO:0019233	sensory perception of pain
0.55	GO:0071315	cellular response to morphine
0.54	GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
0.53	GO:0048149	behavioral response to ethanol
0.52	GO:0050769	positive regulation of neurogenesis
0.51	GO:0007212	dopamine receptor signaling pathway
0.51	GO:0019933	cAMP-mediated signaling

0.86	GO:0004979	beta-endorphin receptor activity
0.58	GO:0001965	G-protein alpha-subunit binding
0.55	GO:0038047	morphine receptor activity
0.49	GO:0031681	G-protein beta-subunit binding
0.48	GO:0042923	neuropeptide binding
0.45	GO:0038046	enkephalin receptor activity
0.43	GO:0005245	voltage-gated calcium channel activity
0.39	GO:0031005	filamin binding
0.38	GO:0008022	protein C-terminus binding
0.37	GO:0019904	protein domain specific binding

0.46	GO:0043005	neuron projection
0.44	GO:0043204	perikaryon
0.42	GO:0120038	plasma membrane bounded cell projection part
0.42	GO:0005768	endosome
0.41	GO:0005887	integral component of plasma membrane
0.38	GO:0042383	sarcolemma
0.38	GO:0031256	leading edge membrane
0.38	GO:0005925	focal adhesion
0.38	GO:0098857	membrane microdomain
0.37	GO:0098794	postsynapse

sp|P35398|RORA_HUMAN
Nuclear receptor ROR-alpha
Search

RORA

0.97	Thyroid hormone nuclear receptor alpha

0.79	GO:0030522	intracellular receptor signaling pathway
0.78	GO:0043401	steroid hormone mediated signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.55	GO:0021924	cell proliferation in external granule layer
0.55	GO:0072539	T-helper 17 cell differentiation
0.55	GO:2000188	regulation of cholesterol homeostasis
0.54	GO:0010575	positive regulation of vascular endothelial growth factor production

0.81	GO:0004879	nuclear receptor activity
0.79	GO:0003707	steroid hormone receptor activity
0.63	GO:0043565	sequence-specific DNA binding
0.61	GO:0008270	zinc ion binding
0.56	GO:0008142	oxysterol binding
0.55	GO:0001222	transcription corepressor binding
0.55	GO:0001223	transcription coactivator binding
0.52	GO:0001047	core promoter binding
0.52	GO:0008013	beta-catenin binding
0.50	GO:0001012	RNA polymerase II regulatory region DNA binding

0.61	GO:0005634	nucleus
0.36	GO:0070013	intracellular organelle lumen
0.35	GO:0044446	intracellular organelle part
0.34	GO:0043234	protein complex

sp|P35408|PE2R4_HUMAN
Prostaglandin E2 receptor EP4 subtype
Search

PTGER4

0.95	Prostaglandin E receptor 4

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.65	GO:2000419	regulation of eosinophil extravasation
0.65	GO:2000417	negative regulation of eosinophil migration
0.64	GO:0033624	negative regulation of integrin activation
0.63	GO:0002692	negative regulation of cellular extravasation
0.60	GO:0050728	negative regulation of inflammatory response
0.59	GO:0042093	T-helper cell differentiation
0.59	GO:0050710	negative regulation of cytokine secretion
0.58	GO:0071260	cellular response to mechanical stimulus
0.58	GO:0050715	positive regulation of cytokine secretion

0.85	GO:0004957	prostaglandin E receptor activity
0.34	GO:0005515	protein binding

0.37	GO:0005886	plasma membrane
0.35	GO:0044306	neuron projection terminus
0.35	GO:0043025	neuronal cell body
0.35	GO:0031965	nuclear membrane
0.32	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|P35410|MAS1L_HUMAN
Mas-related G-protein coupled receptor MRG
Search

0.93	G-protein coupled adenine receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.44	GO:0002279	mast cell activation involved in immune response
0.43	GO:0002448	mast cell mediated immunity
0.43	GO:0070528	protein kinase C signaling
0.43	GO:0043299	leukocyte degranulation
0.43	GO:0032418	lysosome localization
0.43	GO:0007250	activation of NF-kappaB-inducing kinase activity
0.42	GO:1904385	cellular response to angiotensin
0.41	GO:0050727	regulation of inflammatory response
0.41	GO:0051656	establishment of organelle localization

0.72	GO:0004930	G-protein coupled receptor activity
0.43	GO:0042277	peptide binding
0.42	GO:0001653	peptide receptor activity
0.36	GO:0042562	hormone binding
0.33	GO:0005515	protein binding

0.46	GO:0005887	integral component of plasma membrane
0.43	GO:0042629	mast cell granule
0.40	GO:0005654	nucleoplasm
0.40	GO:0005829	cytosol
0.36	GO:0009986	cell surface

sp|P35414|APJ_HUMAN
Apelin receptor
Search

APLNR

0.97	G-protein coupled receptor APJ

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.67	GO:1904325	positive regulation of inhibitory G-protein coupled receptor phosphorylation
0.64	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
0.64	GO:0043951	negative regulation of cAMP-mediated signaling
0.63	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
0.62	GO:0007512	adult heart development
0.61	GO:0060976	coronary vasculature development
0.61	GO:0048514	blood vessel morphogenesis
0.56	GO:0030154	cell differentiation
0.49	GO:0007369	gastrulation

0.72	GO:0004930	G-protein coupled receptor activity
0.43	GO:0001653	peptide receptor activity
0.36	GO:0042277	peptide binding
0.35	GO:0004931	extracellularly ATP-gated cation channel activity
0.35	GO:0001614	purinergic nucleotide receptor activity
0.33	GO:0004875	complement receptor activity
0.33	GO:0004896	cytokine receptor activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0005886	plasma membrane
0.34	GO:0098794	postsynapse
0.32	GO:0043005	neuron projection
0.32	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|P35442|TSP2_HUMAN
Thrombospondin-2
Search

THBS2

0.96	Thrombospondin-2

0.84	GO:0016525	negative regulation of angiogenesis
0.81	GO:0030198	extracellular matrix organization
0.72	GO:0007155	cell adhesion
0.48	GO:0006954	inflammatory response
0.43	GO:0002605	negative regulation of dendritic cell antigen processing and presentation
0.43	GO:0010754	negative regulation of cGMP-mediated signaling
0.43	GO:0010751	negative regulation of nitric oxide mediated signal transduction
0.43	GO:2001027	negative regulation of endothelial cell chemotaxis
0.43	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport
0.42	GO:0010757	negative regulation of plasminogen activation

0.83	GO:0008201	heparin binding
0.70	GO:0005509	calcium ion binding
0.50	GO:0050840	extracellular matrix binding
0.43	GO:0070052	collagen V binding
0.43	GO:0070051	fibrinogen binding
0.42	GO:0030169	low-density lipoprotein particle binding
0.42	GO:0001968	fibronectin binding
0.42	GO:0017134	fibroblast growth factor binding
0.42	GO:0001786	phosphatidylserine binding
0.41	GO:0005178	integrin binding

0.74	GO:0031012	extracellular matrix
0.58	GO:0031091	platelet alpha granule
0.53	GO:0005615	extracellular space
0.40	GO:0009897	external side of plasma membrane
0.36	GO:0043234	protein complex
0.36	GO:0016529	sarcoplasmic reticulum
0.34	GO:0034774	secretory granule lumen
0.34	GO:0005788	endoplasmic reticulum lumen
0.34	GO:1903561	extracellular vesicle
0.30	GO:0016021	integral component of membrane

sp|P35443|TSP4_HUMAN
Thrombospondin-4
Search

THBS4

0.96	thrombospondin-4-B

0.81	GO:0030198	extracellular matrix organization
0.72	GO:0007155	cell adhesion
0.61	GO:0051451	myoblast migration
0.61	GO:0048266	behavioral response to pain
0.61	GO:0090023	positive regulation of neutrophil chemotaxis
0.59	GO:0034103	regulation of tissue remodeling
0.59	GO:0001938	positive regulation of endothelial cell proliferation
0.58	GO:0016525	negative regulation of angiogenesis
0.58	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
0.56	GO:0034976	response to endoplasmic reticulum stress

0.70	GO:0005509	calcium ion binding
0.59	GO:0008201	heparin binding
0.58	GO:0005178	integrin binding
0.42	GO:0005518	collagen binding
0.41	GO:0043395	heparan sulfate proteoglycan binding
0.41	GO:0002020	protease binding
0.40	GO:0008083	growth factor activity
0.36	GO:0043237	laminin-1 binding
0.36	GO:0001968	fibronectin binding

0.74	GO:0031012	extracellular matrix
0.59	GO:0016529	sarcoplasmic reticulum
0.54	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.35	GO:0031594	neuromuscular junction

sp|P35452|HXD12_HUMAN
Homeobox protein Hox-D12
Search

HOXD12

0.96	Homeobox protein Hox-D12

0.60	GO:0042733	embryonic digit morphogenesis
0.57	GO:0001501	skeletal system development
0.56	GO:0007389	pattern specification process
0.53	GO:2001141	regulation of RNA biosynthetic process
0.53	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:0010468	regulation of gene expression
0.36	GO:0006351	transcription, DNA-templated

0.60	GO:0043565	sequence-specific DNA binding
0.35	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.54	GO:0005667	transcription factor complex

sp|P35453|HXD13_HUMAN
Homeobox protein Hox-D13
Search

HOXD13

0.88	Transcription factor HoxD13

0.58	GO:0060526	prostate glandular acinus morphogenesis
0.58	GO:0060687	regulation of branching involved in prostate gland morphogenesis
0.57	GO:0060442	branching involved in prostate gland morphogenesis
0.57	GO:0060602	branch elongation of an epithelium
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0060571	morphogenesis of an epithelial fold
0.56	GO:0030539	male genitalia development
0.56	GO:0010468	regulation of gene expression
0.55	GO:0042733	embryonic digit morphogenesis

0.64	GO:0043565	sequence-specific DNA binding
0.55	GO:0035326	enhancer binding
0.54	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.52	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.51	GO:0001012	RNA polymerase II regulatory region DNA binding
0.51	GO:0003682	chromatin binding
0.49	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P35462|DRD3_HUMAN
D(3) dopamine receptor
Search

DRD3

0.90	Dopamine D2 receptor transcript variant 4

0.84	GO:0007212	dopamine receptor signaling pathway
0.80	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.61	GO:0060160	negative regulation of dopamine receptor signaling pathway
0.60	GO:0050883	musculoskeletal movement, spinal reflex action
0.60	GO:0048148	behavioral response to cocaine
0.60	GO:0002031	G-protein coupled receptor internalization
0.60	GO:0014059	regulation of dopamine secretion
0.60	GO:0043278	response to morphine
0.60	GO:0002016	regulation of blood volume by renin-angiotensin
0.59	GO:0034776	response to histamine

0.85	GO:0004952	dopamine neurotransmitter receptor activity
0.46	GO:0035240	dopamine binding
0.43	GO:0031748	D1 dopamine receptor binding
0.40	GO:0019904	protein domain specific binding
0.38	GO:0004935	adrenergic receptor activity
0.36	GO:0042802	identical protein binding
0.36	GO:0035255	ionotropic glutamate receptor binding
0.34	GO:0046982	protein heterodimerization activity
0.34	GO:0015459	potassium channel regulator activity

0.65	GO:0005887	integral component of plasma membrane
0.42	GO:0030139	endocytic vesicle
0.41	GO:0045177	apical part of cell
0.40	GO:0042995	cell projection
0.39	GO:0030672	synaptic vesicle membrane
0.37	GO:0036477	somatodendritic compartment
0.36	GO:0098590	plasma membrane region
0.35	GO:0016328	lateral plasma membrane
0.35	GO:0001669	acrosomal vesicle
0.35	GO:0014069	postsynaptic density

sp|P35475|IDUA_HUMAN
Alpha-L-iduronidase
Search

IDUA

0.97	Alpha-L-iduronidase

0.62	GO:0030209	dermatan sulfate catabolic process
0.60	GO:0005975	carbohydrate metabolic process
0.37	GO:0007040	lysosome organization
0.37	GO:0035108	limb morphogenesis
0.37	GO:0030207	chondroitin sulfate catabolic process
0.37	GO:0048705	skeletal system morphogenesis
0.36	GO:0000902	cell morphogenesis
0.36	GO:0048878	chemical homeostasis

0.66	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.37	GO:0005102	receptor binding

0.41	GO:0005764	lysosome
0.38	GO:0030135	coated vesicle
0.37	GO:0070062	extracellular exosome
0.36	GO:0005775	vacuolar lumen

0.66

EC:3.2.1

GO:0004553

sp|P35498|SCN1A_HUMAN
Sodium channel protein type 1 subunit alpha
Search

0.66	Sodium channel protein type 1 subunit alpha

0.77	GO:0035725	sodium ion transmembrane transport
0.76	GO:0034765	regulation of ion transmembrane transport
0.59	GO:0019228	neuronal action potential
0.54	GO:0086010	membrane depolarization during action potential
0.52	GO:0098870	action potential propagation
0.52	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
0.52	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress
0.52	GO:0086002	cardiac muscle cell action potential involved in contraction
0.52	GO:0050884	neuromuscular process controlling posture
0.51	GO:0007628	adult walking behavior

0.84	GO:0005248	voltage-gated sodium channel activity
0.73	GO:0022832	voltage-gated channel activity
0.71	GO:0022839	ion gated channel activity
0.71	GO:0008381	mechanosensitive ion channel activity
0.36	GO:0031402	sodium ion binding
0.35	GO:0043522	leucine zipper domain binding

0.83	GO:0001518	voltage-gated sodium channel complex
0.58	GO:0030315	T-tubule
0.58	GO:0014704	intercalated disc
0.57	GO:0044304	main axon
0.50	GO:0030018	Z disc
0.49	GO:0043025	neuronal cell body
0.48	GO:0016604	nuclear body

sp|P35499|SCN4A_HUMAN
Sodium channel protein type 4 subunit alpha
Search

SCN4A

0.56	Sodium channel protein type 4 subunit alpha

0.77	GO:0035725	sodium ion transmembrane transport
0.75	GO:0034765	regulation of ion transmembrane transport
0.53	GO:0019228	neuronal action potential
0.52	GO:0086010	membrane depolarization during action potential
0.37	GO:0006936	muscle contraction
0.37	GO:0015871	choline transport
0.36	GO:0006813	potassium ion transport
0.33	GO:0010469	regulation of receptor activity

0.84	GO:0005248	voltage-gated sodium channel activity
0.72	GO:0022832	voltage-gated channel activity
0.70	GO:0022839	ion gated channel activity
0.70	GO:0008381	mechanosensitive ion channel activity
0.39	GO:0005509	calcium ion binding
0.34	GO:0005267	potassium channel activity
0.33	GO:0005179	hormone activity

0.83	GO:0001518	voltage-gated sodium channel complex
0.34	GO:0008076	voltage-gated potassium channel complex
0.33	GO:0005576	extracellular region

sp|P35503|UD13_HUMAN
UDP-glucuronosyltransferase 1-3
Search

0.54	UDP-glucuronosyltransferase

0.59	GO:0052695	cellular glucuronidation
0.55	GO:0009812	flavonoid metabolic process
0.51	GO:0006805	xenobiotic metabolic process
0.46	GO:2001030	negative regulation of cellular glucuronidation
0.45	GO:1904223	regulation of glucuronosyltransferase activity
0.43	GO:0043086	negative regulation of catalytic activity
0.42	GO:0045922	negative regulation of fatty acid metabolic process
0.41	GO:0031100	animal organ regeneration
0.41	GO:0042440	pigment metabolic process
0.40	GO:0001889	liver development

0.80	GO:0015020	glucuronosyltransferase activity
0.50	GO:0001972	retinoic acid binding
0.48	GO:0042803	protein homodimerization activity
0.48	GO:0046982	protein heterodimerization activity
0.45	GO:0019899	enzyme binding
0.43	GO:0005496	steroid binding
0.42	GO:0004857	enzyme inhibitor activity
0.38	GO:0005504	fatty acid binding
0.34	GO:0008144	drug binding

0.48	GO:0005783	endoplasmic reticulum
0.44	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.43	GO:0031984	organelle subcompartment
0.39	GO:0005887	integral component of plasma membrane
0.37	GO:0043234	protein complex
0.36	GO:0070062	extracellular exosome
0.33	GO:0031966	mitochondrial membrane
0.33	GO:0019866	organelle inner membrane

0.80

GO:0015020

sp|P35504|UD15_HUMAN
UDP-glucuronosyltransferase 1-5
Search

0.54	UDP-glucuronosyltransferase

0.59	GO:0052695	cellular glucuronidation
0.55	GO:0009812	flavonoid metabolic process
0.51	GO:0006805	xenobiotic metabolic process
0.46	GO:2001030	negative regulation of cellular glucuronidation
0.45	GO:1904223	regulation of glucuronosyltransferase activity
0.43	GO:0043086	negative regulation of catalytic activity
0.42	GO:0045922	negative regulation of fatty acid metabolic process
0.41	GO:0042440	pigment metabolic process
0.41	GO:0031100	animal organ regeneration
0.40	GO:0001889	liver development

0.80	GO:0015020	glucuronosyltransferase activity
0.50	GO:0001972	retinoic acid binding
0.48	GO:0042803	protein homodimerization activity
0.48	GO:0046982	protein heterodimerization activity
0.44	GO:0019899	enzyme binding
0.43	GO:0005496	steroid binding
0.42	GO:0004857	enzyme inhibitor activity
0.36	GO:0005504	fatty acid binding
0.33	GO:0008144	drug binding

0.48	GO:0005783	endoplasmic reticulum
0.44	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.42	GO:0031984	organelle subcompartment
0.39	GO:0005887	integral component of plasma membrane
0.37	GO:0043234	protein complex
0.36	GO:0070062	extracellular exosome
0.33	GO:0031966	mitochondrial membrane
0.33	GO:0019866	organelle inner membrane

0.80