Queries 3001 to 4000

GO:0036459

sp|O75319|DUS11_HUMAN
RNA/RNP complex-1-interacting phosphatase
Search

DUSP11

0.91	Dual specificity protein phosphatase 1

0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.58	GO:0098507	polynucleotide 5' dephosphorylation
0.42	GO:0016070	RNA metabolic process
0.33	GO:0010467	gene expression
0.32	GO:0016310	phosphorylation

0.78	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.74	GO:0004725	protein tyrosine phosphatase activity
0.58	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides
0.58	GO:0004651	polynucleotide 5'-phosphatase activity
0.44	GO:0003723	RNA binding
0.33	GO:0016772	transferase activity, transferring phosphorus-containing groups

0.57	GO:0045171	intercellular bridge
0.56	GO:0001650	fibrillar center
0.55	GO:0016607	nuclear speck

0.78

GO:0008138

sp|O75323|NIPS2_HUMAN
Protein NipSnap homolog 2
Search

NIPSNAP2

0.97	Nipsnap homolog 2

0.85	GO:2000984	negative regulation of ATP citrate synthase activity
0.64	GO:0006754	ATP biosynthetic process
0.59	GO:0006119	oxidative phosphorylation
0.50	GO:1901843	positive regulation of high voltage-gated calcium channel activity
0.48	GO:0019233	sensory perception of pain

0.47	GO:0042165	neurotransmitter binding
0.36	GO:0005515	protein binding

0.70	GO:0005741	mitochondrial outer membrane
0.46	GO:0097060	synaptic membrane
0.40	GO:0019866	organelle inner membrane
0.37	GO:0005887	integral component of plasma membrane

sp|O75324|SNN_HUMAN
Stannin
Search

SNN

0.79

Stannin

0.34

GO:0009636

response to toxic substance

0.45	GO:0046872	metal ion binding
0.33	GO:0003677	DNA binding

0.42	GO:0005737	cytoplasm
0.40	GO:0031968	organelle outer membrane
0.35	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0044425	membrane part

sp|O75325|LRRN2_HUMAN
Leucine-rich repeat neuronal protein 2
Search

LRRN2

0.97	LOW QUALITY PROTEIN: leucine-rich repeat neuronal protein 2

0.49	GO:0007409	axonogenesis
0.45	GO:0051965	positive regulation of synapse assembly
0.41	GO:0021628	olfactory nerve formation
0.40	GO:0071699	olfactory placode morphogenesis
0.35	GO:0007155	cell adhesion
0.34	GO:0007165	signal transduction

0.34	GO:0004872	receptor activity
0.33	GO:0005515	protein binding

0.48	GO:0005578	proteinaceous extracellular matrix
0.47	GO:0005615	extracellular space
0.30	GO:0016020	membrane

sp|O75326|SEM7A_HUMAN
Semaphorin-7A
Search

SEMA7A

0.97	Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

0.66	GO:0060907	positive regulation of macrophage cytokine production
0.64	GO:0045773	positive regulation of axon extension
0.63	GO:0021988	olfactory lobe development
0.62	GO:0048675	axon extension
0.62	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.60	GO:0050727	regulation of inflammatory response
0.60	GO:0007229	integrin-mediated signaling pathway
0.55	GO:0050919	negative chemotaxis
0.40	GO:0001649	osteoblast differentiation
0.39	GO:0006954	inflammatory response

0.62	GO:0005178	integrin binding
0.56	GO:0038191	neuropilin binding
0.34	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.33	GO:0020037	heme binding
0.33	GO:0005506	iron ion binding

0.60	GO:0009897	external side of plasma membrane
0.49	GO:0005615	extracellular space
0.39	GO:0031225	anchored component of membrane
0.32	GO:0034998	oligosaccharyltransferase I complex
0.30	GO:0016021	integral component of membrane

0.34

EC:1.14

GO:0016705

sp|O75330|HMMR_HUMAN
Hyaluronan mediated motility receptor
Search

HMMR

0.91	Hyaluronan mediated motility receptor

0.37	GO:0035023	regulation of Rho protein signal transduction
0.37	GO:0061026	cardiac muscle tissue regeneration
0.36	GO:0042981	regulation of apoptotic process
0.36	GO:0065009	regulation of molecular function
0.35	GO:0007267	cell-cell signaling
0.35	GO:0007010	cytoskeleton organization
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression
0.33	GO:0006351	transcription, DNA-templated

0.85	GO:0005540	hyaluronic acid binding
0.37	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.32	GO:0032550	purine ribonucleoside binding
0.32	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003700	DNA binding transcription factor activity

0.58	GO:0005813	centrosome
0.53	GO:0005829	cytosol
0.38	GO:0009986	cell surface
0.35	GO:0016592	mediator complex
0.31	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O75333|TBX10_HUMAN
T-box transcription factor TBX10
Search

TBX1

0.93	T-box transcription factor

0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.48	GO:0060017	parathyroid gland development
0.47	GO:0060023	soft palate development
0.47	GO:0060037	pharyngeal system development
0.47	GO:0048538	thymus development
0.46	GO:0048703	embryonic viscerocranium morphogenesis
0.45	GO:0007507	heart development

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.43	GO:0042803	protein homodimerization activity
0.35	GO:0001067	regulatory region nucleic acid binding
0.33	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.33	GO:0016787	hydrolase activity
0.33	GO:0005525	GTP binding

0.61	GO:0005634	nucleus
0.34	GO:0008021	synaptic vesicle
0.30	GO:0016020	membrane

0.33

EC:1.2.1

GO:0016620

sp|O75334|LIPA2_HUMAN
Liprin-alpha-2
Search

PPFIA2

0.94	PTPRF interacting protein alpha 2

0.36	GO:0014047	glutamate secretion
0.35	GO:0099643	signal release from synapse
0.35	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.35	GO:0007160	cell-matrix adhesion
0.34	GO:0006836	neurotransmitter transport
0.34	GO:0001505	regulation of neurotransmitter levels
0.34	GO:0051649	establishment of localization in cell

0.36

GO:0032403

protein complex binding

0.76	GO:0045202	synapse
0.36	GO:0070062	extracellular exosome
0.36	GO:0009986	cell surface
0.34	GO:0097458	neuron part
0.34	GO:0005829	cytosol

sp|O75335|LIPA4_HUMAN
Liprin-alpha-4
Search

PPFIA4

0.87	PTPRF interacting protein alpha 4

0.39	GO:0014047	glutamate secretion
0.38	GO:0099643	signal release from synapse
0.38	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.37	GO:0006836	neurotransmitter transport
0.36	GO:0001505	regulation of neurotransmitter levels
0.36	GO:0051649	establishment of localization in cell

0.38	GO:0005515	protein binding
0.34	GO:0044877	macromolecular complex binding

0.77	GO:0048786	presynaptic active zone
0.38	GO:0009986	cell surface
0.36	GO:0005829	cytosol
0.34	GO:0070062	extracellular exosome

sp|O75339|CILP1_HUMAN
Cartilage intermediate layer protein 1
Search

CILP

0.97	Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase

0.83

GO:0043569

negative regulation of insulin-like growth factor receptor signaling pathway

0.49	GO:0030246	carbohydrate binding
0.42	GO:0004035	alkaline phosphatase activity
0.42	GO:0004551	nucleotide diphosphatase activity
0.36	GO:0030554	adenyl nucleotide binding
0.35	GO:0097367	carbohydrate derivative binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0003677	DNA binding

0.68	GO:0031012	extracellular matrix
0.67	GO:0005615	extracellular space
0.42	GO:1903561	extracellular vesicle

0.42

EC:3.1.3.1

GO:0004035

sp|O75340|PDCD6_HUMAN
Programmed cell death protein 6
Search

PDCD6

0.93	LOW QUALITY PROTEIN: programmed cell death protein 6

0.54	GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway
0.53	GO:1902527	positive regulation of protein monoubiquitination
0.52	GO:0014029	neural crest formation
0.52	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
0.51	GO:0051898	negative regulation of protein kinase B signaling
0.50	GO:0001938	positive regulation of endothelial cell proliferation
0.50	GO:0010595	positive regulation of endothelial cell migration
0.50	GO:0048208	COPII vesicle coating
0.50	GO:0014032	neural crest cell development
0.50	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

0.68	GO:0005509	calcium ion binding
0.51	GO:0043495	protein membrane anchor
0.51	GO:0048306	calcium-dependent protein binding
0.48	GO:0060090	molecular adaptor activity
0.46	GO:0042803	protein homodimerization activity
0.46	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.41	GO:0000287	magnesium ion binding

0.51	GO:0070971	endoplasmic reticulum exit site
0.49	GO:0031463	Cul3-RING ubiquitin ligase complex
0.48	GO:0030127	COPII vesicle coat
0.46	GO:0000139	Golgi membrane
0.42	GO:0005634	nucleus
0.37	GO:0005768	endosome
0.37	GO:0005789	endoplasmic reticulum membrane
0.37	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

sp|O75342|LX12B_HUMAN
Arachidonate 12-lipoxygenase, 12R-type
Search

0.97	Epidermis-type lipoxygenase 3

0.73	GO:0019372	lipoxygenase pathway
0.73	GO:0043651	linoleic acid metabolic process
0.70	GO:0019369	arachidonic acid metabolic process
0.67	GO:0061436	establishment of skin barrier
0.66	GO:0046513	ceramide biosynthetic process
0.62	GO:0070257	positive regulation of mucus secretion
0.58	GO:0009967	positive regulation of signal transduction
0.56	GO:0051122	hepoxilin biosynthetic process
0.55	GO:0043408	regulation of MAPK cascade
0.55	GO:0006497	protein lipidation

0.75	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
0.61	GO:0005506	iron ion binding
0.53	GO:0051120	hepoxilin A3 synthase activity
0.42	GO:0005509	calcium ion binding
0.36	GO:0005515	protein binding
0.35	GO:0008289	lipid binding
0.35	GO:0016829	lyase activity

0.44	GO:0019898	extrinsic component of membrane
0.43	GO:0005829	cytosol
0.42	GO:0005856	cytoskeleton
0.38	GO:0005886	plasma membrane
0.35	GO:0070062	extracellular exosome
0.34	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.75

EC:1.13.11

GO:0016702

sp|O75343|GCYB2_HUMAN
Guanylate cyclase soluble subunit beta-2
Search

0.97	Guanylate cyclase soluble subunit beta-2

0.82	GO:0006182	cGMP biosynthetic process
0.62	GO:0035556	intracellular signal transduction
0.37	GO:0006468	protein phosphorylation
0.36	GO:0007631	feeding behavior
0.35	GO:0070482	response to oxygen levels

0.83	GO:0004383	guanylate cyclase activity
0.61	GO:0020037	heme binding
0.52	GO:1901265	nucleoside phosphate binding
0.50	GO:0036094	small molecule binding
0.48	GO:0004016	adenylate cyclase activity
0.37	GO:0004672	protein kinase activity
0.37	GO:0019826	oxygen sensor activity
0.36	GO:0097367	carbohydrate derivative binding
0.36	GO:0043168	anion binding
0.33	GO:0046872	metal ion binding

0.51	GO:0008074	guanylate cyclase complex, soluble
0.40	GO:0005886	plasma membrane
0.35	GO:0043025	neuronal cell body
0.35	GO:0030425	dendrite
0.30	GO:0016021	integral component of membrane

0.83

EC:4.6.1.2

GO:0004383

sp|O75344|FKBP6_HUMAN
Inactive peptidyl-prolyl cis-trans isomerase FKBP6
Search

FKBP6

0.60	Inactive peptidyl-prolyl cis-trans isomerase FKBP6

0.85	GO:0043046	DNA methylation involved in gamete generation
0.85	GO:0034587	piRNA metabolic process
0.79	GO:0045070	positive regulation of viral genome replication
0.78	GO:0007283	spermatogenesis
0.77	GO:0031047	gene silencing by RNA
0.76	GO:0061077	chaperone-mediated protein folding
0.75	GO:0051321	meiotic cell cycle
0.70	GO:0000413	protein peptidyl-prolyl isomerization
0.70	GO:0030154	cell differentiation

0.85	GO:0051879	Hsp90 protein binding
0.83	GO:0005528	FK506 binding
0.70	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.67	GO:0042802	identical protein binding

0.83	GO:0000795	synaptonemal complex
0.66	GO:0005829	cytosol
0.47	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.70

EC:5.2.1.8

GO:0003755

sp|O75346|ZN253_HUMAN
Zinc finger protein 253
Search

0.79	Zinc finger protein 506

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.42	GO:0070895	negative regulation of transposon integration
0.40	GO:0006351	transcription, DNA-templated
0.37	GO:1902679	negative regulation of RNA biosynthetic process

0.51	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.41	GO:0003700	DNA binding transcription factor activity

0.45	GO:0005622	intracellular
0.40	GO:0043227	membrane-bounded organelle
0.38	GO:0031974	membrane-enclosed lumen
0.36	GO:0043228	non-membrane-bounded organelle
0.36	GO:0044422	organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|O75347|TBCA_HUMAN
Tubulin-specific chaperone A
Search

TBCA

0.74	Tubulin-specific chaperone A

0.84	GO:0007021	tubulin complex assembly
0.84	GO:0007023	post-chaperonin tubulin folding pathway
0.38	GO:0007420	brain development

0.84	GO:0048487	beta-tubulin binding
0.34	GO:0051087	chaperone binding
0.34	GO:0003723	RNA binding

0.73	GO:0005874	microtubule
0.49	GO:0005737	cytoplasm
0.46	GO:0005730	nucleolus
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

sp|O75348|VATG1_HUMAN
V-type proton ATPase subunit G 1
Search

ATP6V1G1

0.68	V-type proton ATPase subunit G

0.62	GO:0015992	proton transport
0.55	GO:0055085	transmembrane transport
0.54	GO:0036295	cellular response to increased oxygen levels
0.49	GO:0006879	cellular iron ion homeostasis
0.37	GO:0090383	phagosome acidification
0.36	GO:0033572	transferrin transport
0.36	GO:0008286	insulin receptor signaling pathway
0.36	GO:0016241	regulation of macroautophagy
0.32	GO:0055114	oxidation-reduction process

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.53	GO:0051117	ATPase binding
0.47	GO:0022853	active ion transmembrane transporter activity
0.44	GO:0015078	hydrogen ion transmembrane transporter activity
0.34	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
0.33	GO:0020037	heme binding
0.33	GO:0005506	iron ion binding

0.82	GO:0016471	vacuolar proton-transporting V-type ATPase complex
0.49	GO:0005765	lysosomal membrane
0.45	GO:0005829	cytosol
0.44	GO:0030285	integral component of synaptic vesicle membrane
0.41	GO:0005886	plasma membrane
0.38	GO:0042470	melanosome
0.36	GO:0070062	extracellular exosome

0.34

EC:1.14.14

GO:0016712

sp|O75351|VPS4B_HUMAN
Vacuolar protein sorting-associated protein 4B
Search

VPS4B

0.92	Vacuolar protein sorting-associated protein 4B

0.61	GO:0061738	late endosomal microautophagy
0.59	GO:0036258	multivesicular body assembly
0.58	GO:1903724	positive regulation of centriole elongation
0.57	GO:0090611	ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
0.57	GO:1903542	negative regulation of exosomal secretion
0.56	GO:1903543	positive regulation of exosomal secretion
0.56	GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway
0.56	GO:1902188	positive regulation of viral release from host cell
0.54	GO:0000920	cell separation after cytokinesis
0.54	GO:1901673	regulation of mitotic spindle assembly

0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0008022	protein C-terminus binding
0.49	GO:0042803	protein homodimerization activity
0.45	GO:0016887	ATPase activity
0.35	GO:0019904	protein domain specific binding
0.34	GO:0017048	Rho GTPase binding

0.55	GO:0090543	Flemming body
0.51	GO:0000922	spindle pole
0.51	GO:0010008	endosome membrane
0.51	GO:0005813	centrosome
0.47	GO:0005829	cytosol
0.46	GO:0005634	nucleus
0.42	GO:0048471	perinuclear region of cytoplasm
0.40	GO:0005770	late endosome
0.37	GO:0070062	extracellular exosome
0.35	GO:0036452	ESCRT complex

0.45

EC:3.6.1.3

GO:0016887

sp|O75352|MPU1_HUMAN
Mannose-P-dolichol utilization defect 1 protein
Search

MPDU1

0.86	Mannose-P-dolichol utilization defect 1

0.51	GO:0009312	oligosaccharide biosynthetic process
0.47	GO:0006488	dolichol-linked oligosaccharide biosynthetic process
0.34	GO:0006457	protein folding
0.34	GO:0006413	translational initiation

0.34	GO:0004004	ATP-dependent RNA helicase activity
0.34	GO:0003743	translation initiation factor activity
0.33	GO:0005515	protein binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.37	GO:0070062	extracellular exosome
0.34	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

sp|O75354|ENTP6_HUMAN
Ectonucleoside triphosphate diphosphohydrolase 6
Search

ENTPD6

0.97	Ectonucleoside triphosphate diphosphohydrolase 6

0.40	GO:0032026	response to magnesium ion
0.39	GO:0051592	response to calcium ion
0.37	GO:0034656	nucleobase-containing small molecule catabolic process

0.50

GO:0016787

hydrolase activity

0.49	GO:0005794	Golgi apparatus
0.38	GO:0009986	cell surface
0.37	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.36	GO:0098588	bounding membrane of organelle
0.35	GO:0031984	organelle subcompartment
0.34	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.50

GO:0016787

sp|O75355|ENTP3_HUMAN
Ectonucleoside triphosphate diphosphohydrolase 3
Search

ENTPD3

0.97	Ecto-nucleosidase triphosphate diphosphohydrolase 3

0.60	GO:0009134	nucleoside diphosphate catabolic process
0.53	GO:0009143	nucleoside triphosphate catabolic process
0.37	GO:0034656	nucleobase-containing small molecule catabolic process
0.36	GO:0071405	cellular response to methanol
0.35	GO:0045471	response to ethanol
0.35	GO:0046688	response to copper ion
0.34	GO:0006413	translational initiation
0.34	GO:0030168	platelet activation
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0009185	ribonucleoside diphosphate metabolic process

0.56	GO:0017110	nucleoside-diphosphatase activity
0.44	GO:0017111	nucleoside-triphosphatase activity
0.40	GO:0102491	dGTP phosphohydrolase activity
0.40	GO:0102487	dUTP phosphohydrolase activity
0.40	GO:0102488	dTTP phosphohydrolase activity
0.40	GO:0102489	GTP phosphohydrolase activity
0.40	GO:0102490	8-oxo-dGTP phosphohydrolase activity
0.40	GO:0102486	dCTP phosphohydrolase activity
0.40	GO:0102485	dATP phosphohydrolase activity
0.40	GO:0008253	5'-nucleotidase activity

0.43	GO:0005886	plasma membrane
0.34	GO:0005605	basal lamina
0.30	GO:0016021	integral component of membrane

0.56

EC:3.6.1.6

GO:0017110

sp|O75356|ENTP5_HUMAN
Ectonucleoside triphosphate diphosphohydrolase 5
Search

ENTPD5

0.96	ectonucleoside triphosphate diphosphohydrolase 5 precursor

0.44	GO:0045821	positive regulation of glycolytic process
0.42	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling
0.42	GO:0051084	'de novo' posttranslational protein folding
0.41	GO:0006487	protein N-linked glycosylation
0.41	GO:0008283	cell proliferation
0.40	GO:0030282	bone mineralization
0.39	GO:0072506	trivalent inorganic anion homeostasis
0.39	GO:0072505	divalent inorganic anion homeostasis
0.39	GO:0055083	monovalent inorganic anion homeostasis
0.37	GO:0046034	ATP metabolic process

0.51	GO:0016787	hydrolase activity
0.33	GO:0005515	protein binding

0.39	GO:0012505	endomembrane system
0.38	GO:0005576	extracellular region
0.36	GO:0043231	intracellular membrane-bounded organelle
0.36	GO:0044444	cytoplasmic part
0.35	GO:0031982	vesicle
0.30	GO:0016020	membrane

0.51

GO:0016787

sp|O75360|PROP1_HUMAN
Homeobox protein prophet of Pit-1
Search

PROP1

0.94	Pituitary specific homeodomain factor

0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.53	GO:0048850	hypophysis morphogenesis
0.53	GO:0060126	somatotropin secreting cell differentiation
0.53	GO:0021979	hypothalamus cell differentiation
0.50	GO:0060070	canonical Wnt signaling pathway
0.50	GO:0009953	dorsal/ventral pattern formation
0.48	GO:0001568	blood vessel development
0.48	GO:0016477	cell migration

0.62	GO:0043565	sequence-specific DNA binding
0.53	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
0.52	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
0.51	GO:0035326	enhancer binding
0.50	GO:0008013	beta-catenin binding
0.50	GO:0008022	protein C-terminus binding
0.48	GO:0001012	RNA polymerase II regulatory region DNA binding
0.47	GO:0003682	chromatin binding
0.46	GO:0003690	double-stranded DNA binding
0.36	GO:0001103	RNA polymerase II repressing transcription factor binding

0.61	GO:0005634	nucleus
0.47	GO:0005667	transcription factor complex
0.35	GO:0000785	chromatin
0.34	GO:0043233	organelle lumen
0.30	GO:0016020	membrane

0.33

EC:3.5.4.4

GO:0004000

sp|O75362|ZN217_HUMAN
Zinc finger protein 217
Search

ZNF217

0.92	Zinc finger domain-containing protein (Fragment)

0.60	GO:0000122	negative regulation of transcription by RNA polymerase II
0.48	GO:0006366	transcription by RNA polymerase II
0.47	GO:0007275	multicellular organism development
0.43	GO:0007165	signal transduction
0.42	GO:0048387	negative regulation of retinoic acid receptor signaling pathway
0.40	GO:0051961	negative regulation of nervous system development
0.40	GO:0010721	negative regulation of cell development
0.39	GO:0048869	cellular developmental process
0.36	GO:0007568	aging

0.64	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.61	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0005515	protein binding
0.34	GO:0046872	metal ion binding

0.61	GO:0000118	histone deacetylase complex
0.60	GO:0016607	nuclear speck
0.48	GO:0005739	mitochondrion

sp|O75363|BCAS1_HUMAN
Breast carcinoma-amplified sequence 1
Search

sp|O75364|PITX3_HUMAN
Pituitary homeobox 3
Search

PITX3

0.94	Pituitary homeobox 3

0.69	GO:0007275	multicellular organism development
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0060322	head development
0.55	GO:0010468	regulation of gene expression
0.54	GO:0060429	epithelium development
0.53	GO:0007626	locomotory behavior
0.52	GO:0006366	transcription by RNA polymerase II
0.51	GO:0009653	anatomical structure morphogenesis
0.51	GO:0048468	cell development

0.63	GO:0043565	sequence-specific DNA binding
0.60	GO:0003700	DNA binding transcription factor activity
0.52	GO:0044212	transcription regulatory region DNA binding
0.50	GO:0003690	double-stranded DNA binding
0.39	GO:0001105	RNA polymerase II transcription coactivator activity
0.39	GO:0001102	RNA polymerase II activating transcription factor binding
0.37	GO:0031490	chromatin DNA binding

0.61	GO:0005634	nucleus
0.39	GO:0043025	neuronal cell body
0.37	GO:0005667	transcription factor complex
0.33	GO:0005737	cytoplasm

sp|O75365|TP4A3_HUMAN
Protein tyrosine phosphatase type IVA 3
Search

PTP4A3

0.97	Protein tyrosine phosphatase type IVA, member 3

0.71	GO:0006470	protein dephosphorylation
0.55	GO:0043542	endothelial cell migration
0.54	GO:1901224	positive regulation of NIK/NF-kappaB signaling
0.52	GO:0043117	positive regulation of vascular permeability
0.52	GO:1900746	regulation of vascular endothelial growth factor signaling pathway
0.51	GO:1904951	positive regulation of establishment of protein localization
0.50	GO:1990830	cellular response to leukemia inhibitory factor
0.49	GO:0007219	Notch signaling pathway
0.41	GO:1903506	regulation of nucleic acid-templated transcription
0.41	GO:2000112	regulation of cellular macromolecule biosynthetic process

0.76	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.49	GO:0004725	protein tyrosine phosphatase activity
0.33	GO:0005515	protein binding

0.45	GO:0005634	nucleus
0.39	GO:0005737	cytoplasm
0.36	GO:0097708	intracellular vesicle
0.35	GO:0012505	endomembrane system
0.34	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.76

GO:0008138

sp|O75366|AVIL_HUMAN
Advillin
Search

AVIL

0.95

Advillin

0.69	GO:0007010	cytoskeleton organization
0.62	GO:0051130	positive regulation of cellular component organization
0.62	GO:0051014	actin filament severing
0.61	GO:0051693	actin filament capping
0.58	GO:0120035	regulation of plasma membrane bounded cell projection organization
0.58	GO:0044089	positive regulation of cellular component biogenesis
0.56	GO:0051094	positive regulation of developmental process
0.56	GO:0051240	positive regulation of multicellular organismal process
0.56	GO:0097435	supramolecular fiber organization
0.53	GO:0030154	cell differentiation

0.78	GO:0051015	actin filament binding
0.62	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.53	GO:0005509	calcium ion binding
0.51	GO:0035727	lysophosphatidic acid binding
0.49	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.45	GO:0042803	protein homodimerization activity

0.49	GO:0032433	filopodium tip
0.48	GO:0005902	microvillus
0.48	GO:0032432	actin filament bundle
0.47	GO:0005903	brush border
0.47	GO:0001726	ruffle
0.47	GO:0030027	lamellipodium
0.38	GO:0005886	plasma membrane
0.38	GO:0030424	axon
0.34	GO:0070062	extracellular exosome
0.34	GO:0005737	cytoplasm

sp|O75367|H2AY_HUMAN
Core histone macro-H2A.1
Search

H2AFY

0.96	Core histone macro-H2A

0.72	GO:0006334	nucleosome assembly
0.67	GO:0016569	covalent chromatin modification
0.59	GO:1904815	negative regulation of protein localization to chromosome, telomeric region
0.59	GO:0033128	negative regulation of histone phosphorylation
0.59	GO:1901837	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
0.58	GO:0051572	negative regulation of histone H3-K4 methylation
0.58	GO:0034184	positive regulation of maintenance of mitotic sister chromatid cohesion
0.58	GO:0061086	negative regulation of histone H3-K27 methylation
0.58	GO:0071169	establishment of protein localization to chromatin
0.57	GO:0045618	positive regulation of keratinocyte differentiation

0.76	GO:0031490	chromatin DNA binding
0.74	GO:0046982	protein heterodimerization activity
0.57	GO:0010385	double-stranded methylated DNA binding
0.56	GO:0000182	rDNA binding
0.56	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
0.54	GO:0030291	protein serine/threonine kinase inhibitor activity
0.54	GO:0031491	nucleosome binding
0.52	GO:0019901	protein kinase binding

0.74	GO:0000786	nucleosome
0.68	GO:0000790	nuclear chromatin
0.56	GO:0001740	Barr body
0.55	GO:0005721	pericentric heterochromatin
0.55	GO:0035098	ESC/E(Z) complex
0.51	GO:0000793	condensed chromosome
0.50	GO:0005730	nucleolus
0.36	GO:0000784	nuclear chromosome, telomeric region
0.36	GO:0070062	extracellular exosome
0.34	GO:0005813	centrosome

sp|O75368|SH3L1_HUMAN
SH3 domain-binding glutamic acid-rich-like protein
Search

SH3BGRL

0.94	SH3 domain binding glutamate rich protein like

0.42

GO:0009967

positive regulation of signal transduction

0.58	GO:0017124	SH3 domain binding
0.44	GO:0005070	SH3/SH2 adaptor activity

0.48	GO:0070062	extracellular exosome
0.48	GO:0005737	cytoplasm
0.38	GO:0005634	nucleus

sp|O75369|FLNB_HUMAN
Filamin-B
Search

0.50

Filamin-B

0.73	GO:0030036	actin cytoskeleton organization
0.71	GO:0030154	cell differentiation
0.47	GO:0071346	cellular response to interferon-gamma
0.46	GO:0007519	skeletal muscle tissue development
0.46	GO:0043588	skin development
0.46	GO:0008544	epidermis development
0.45	GO:0060429	epithelium development
0.44	GO:0000902	cell morphogenesis
0.38	GO:0045185	maintenance of protein location
0.37	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway

0.74	GO:0003779	actin binding
0.48	GO:0045296	cadherin binding
0.45	GO:0042802	identical protein binding
0.39	GO:0032403	protein complex binding
0.37	GO:0034987	immunoglobulin receptor binding
0.36	GO:0048365	Rac GTPase binding
0.36	GO:0030506	ankyrin binding
0.35	GO:0008134	transcription factor binding
0.35	GO:0017160	Ral GTPase binding
0.35	GO:0015459	potassium channel regulator activity

0.47	GO:0097517	contractile actin filament bundle
0.47	GO:0042641	actomyosin
0.46	GO:0005903	brush border
0.46	GO:0045335	phagocytic vesicle
0.46	GO:0005925	focal adhesion
0.44	GO:0005829	cytosol
0.40	GO:0005886	plasma membrane
0.36	GO:0030018	Z disc
0.35	GO:0070062	extracellular exosome
0.35	GO:0031523	Myb complex

sp|O75373|ZN737_HUMAN
Zinc finger protein 737
Search

0.77	Zinc finger protein 92

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.44	GO:0006351	transcription, DNA-templated
0.44	GO:0070895	negative regulation of transposon integration
0.42	GO:0035108	limb morphogenesis
0.39	GO:1902679	negative regulation of RNA biosynthetic process

0.52	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.42	GO:0003700	DNA binding transcription factor activity
0.37	GO:0005515	protein binding

0.47	GO:0005634	nucleus
0.39	GO:0070062	extracellular exosome
0.38	GO:0043233	organelle lumen
0.36	GO:0043232	intracellular non-membrane-bounded organelle
0.36	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|O75376|NCOR1_HUMAN
Nuclear receptor corepressor 1
Search

NCOR1

0.87	Nuclear receptor co-repressor

0.52	GO:0072362	regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
0.51	GO:0072368	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
0.51	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA
0.49	GO:0046329	negative regulation of JNK cascade
0.48	GO:0051225	spindle assembly
0.46	GO:0030223	neutrophil differentiation
0.44	GO:0030902	hindbrain development
0.43	GO:0009952	anterior/posterior pattern specification
0.36	GO:0060318	definitive erythrocyte differentiation
0.36	GO:1904017	cellular response to Thyroglobulin triiodothyronine

0.55	GO:0003677	DNA binding
0.50	GO:0035257	nuclear hormone receptor binding
0.49	GO:0001102	RNA polymerase II activating transcription factor binding
0.48	GO:0003714	transcription corepressor activity
0.48	GO:0042826	histone deacetylase binding
0.36	GO:0035033	histone deacetylase regulator activity
0.35	GO:0042975	peroxisome proliferator activated receptor binding
0.34	GO:0003682	chromatin binding
0.34	GO:0001067	regulatory region nucleic acid binding
0.34	GO:0019904	protein domain specific binding

0.61	GO:0005634	nucleus
0.47	GO:0005876	spindle microtubule
0.47	GO:0017053	transcriptional repressor complex
0.45	GO:0000785	chromatin
0.45	GO:0070013	intracellular organelle lumen
0.45	GO:0005829	cytosol
0.41	GO:1902494	catalytic complex
0.34	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0005667	transcription factor complex
0.30	GO:0016020	membrane

sp|O75379|VAMP4_HUMAN
Vesicle-associated membrane protein 4
Search

VAMP4

0.95	Vesicle associated membrane protein 4

0.69	GO:0016192	vesicle-mediated transport
0.57	GO:0090161	Golgi ribbon formation
0.55	GO:0090174	organelle membrane fusion
0.53	GO:0016050	vesicle organization
0.50	GO:0000226	microtubule cytoskeleton organization
0.48	GO:0043623	cellular protein complex assembly
0.42	GO:0032940	secretion by cell
0.39	GO:0061951	establishment of protein localization to plasma membrane
0.39	GO:0042996	regulation of Golgi to plasma membrane protein transport
0.38	GO:0071346	cellular response to interferon-gamma

0.45	GO:0000149	SNARE binding
0.45	GO:0005484	SNAP receptor activity

0.50	GO:0009986	cell surface
0.48	GO:0005794	Golgi apparatus
0.46	GO:0031201	SNARE complex
0.46	GO:0008021	synaptic vesicle
0.39	GO:0099501	exocytic vesicle membrane
0.38	GO:0045335	phagocytic vesicle
0.38	GO:0031301	integral component of organelle membrane
0.37	GO:0031984	organelle subcompartment
0.35	GO:0030665	clathrin-coated vesicle membrane
0.34	GO:0005764	lysosome

sp|O75380|NDUS6_HUMAN
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Search

NDUFS6

0.91	Mitochondrial NADH dehydrogenase [ubiquinone] iron-sulfur protein 6

0.72	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
0.55	GO:0070584	mitochondrion morphogenesis
0.54	GO:0035264	multicellular organism growth
0.54	GO:0010259	multicellular organism aging
0.53	GO:0006936	muscle contraction
0.52	GO:0072358	cardiovascular system development
0.51	GO:0061458	reproductive system development
0.47	GO:0006631	fatty acid metabolic process
0.36	GO:0032981	mitochondrial respiratory chain complex I assembly

0.35	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.34	GO:0009055	electron transfer activity

0.79

GO:0005747

mitochondrial respiratory chain complex I

0.35

GO:0008137

sp|O75381|PEX14_HUMAN
Peroxisomal membrane protein PEX14
Search

PEX14

0.93	Peroxisomal biogenesis factor 14

0.83	GO:0016560	protein import into peroxisome matrix, docking
0.63	GO:0036250	peroxisome transport along microtubule
0.63	GO:0044721	protein import into peroxisome matrix, substrate release
0.63	GO:1901091	negative regulation of protein tetramerization
0.63	GO:1901093	regulation of protein homotetramerization
0.62	GO:0016561	protein import into peroxisome matrix, translocation
0.61	GO:0032463	negative regulation of protein homooligomerization
0.57	GO:0032091	negative regulation of protein binding
0.57	GO:0034453	microtubule anchoring
0.57	GO:0043433	negative regulation of DNA binding transcription factor activity

0.58	GO:0047485	protein N-terminus binding
0.57	GO:0048487	beta-tubulin binding
0.56	GO:0003714	transcription corepressor activity
0.52	GO:0005102	receptor binding
0.52	GO:0008017	microtubule binding
0.36	GO:0046982	protein heterodimerization activity

0.78	GO:0031903	microbody membrane
0.78	GO:0044439	peroxisomal part
0.57	GO:0001650	fibrillar center
0.50	GO:1990429	peroxisomal importomer complex
0.45	GO:0043234	protein complex
0.36	GO:0044451	nucleoplasm part
0.30	GO:0031224	intrinsic component of membrane

sp|O75382|TRIM3_HUMAN
Tripartite motif-containing protein 3
Search

0.72	Tripartite motif-containing protein 3

0.42	GO:0016567	protein ubiquitination
0.39	GO:0060215	primitive hemopoiesis
0.38	GO:0030099	myeloid cell differentiation
0.30	GO:0008104	protein localization
0.30	GO:0006810	transport
0.30	GO:0007399	nervous system development

0.63	GO:0008270	zinc ion binding
0.42	GO:0004842	ubiquitin-protein transferase activity
0.37	GO:0061659	ubiquitin-like protein ligase activity
0.30	GO:0005515	protein binding

0.45	GO:0005622	intracellular
0.30	GO:0120038	plasma membrane bounded cell projection part
0.30	GO:0097447	dendritic tree
0.30	GO:0031982	vesicle
0.30	GO:0012505	endomembrane system

0.42

GO:0004842

sp|O75385|ULK1_HUMAN
Serine/threonine-protein kinase ULK1
Search

ULK1

0.93	LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1

0.63	GO:0006468	protein phosphorylation
0.52	GO:0007409	axonogenesis
0.47	GO:0075071	autophagy involved in symbiotic interaction
0.44	GO:0018210	peptidyl-threonine modification
0.44	GO:0007165	signal transduction
0.44	GO:0018209	peptidyl-serine modification
0.44	GO:0016236	macroautophagy
0.44	GO:0031333	negative regulation of protein complex assembly
0.43	GO:2000786	positive regulation of autophagosome assembly
0.43	GO:0031102	neuron projection regeneration

0.70	GO:0004674	protein serine/threonine kinase activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0008144	drug binding
0.44	GO:0017137	Rab GTPase binding
0.42	GO:0032403	protein complex binding
0.42	GO:0042802	identical protein binding
0.39	GO:0051879	Hsp90 protein binding
0.38	GO:0004222	metalloendopeptidase activity

0.47	GO:0097635	extrinsic component of autophagosome membrane
0.47	GO:0097629	extrinsic component of omegasome membrane
0.46	GO:0097632	extrinsic component of phagophore assembly site membrane
0.45	GO:0032045	guanyl-nucleotide exchange factor complex
0.45	GO:1990316	Atg1/ULK1 kinase complex
0.43	GO:0043005	neuron projection
0.40	GO:0005829	cytosol
0.39	GO:0031410	cytoplasmic vesicle
0.38	GO:0031012	extracellular matrix
0.38	GO:0043025	neuronal cell body

0.70

GO:0004674

sp|O75386|TULP3_HUMAN
Tubby-related protein 3
Search

TULP3

0.66	Tubby-related protein 3 isoform 1

0.81	GO:0060434	bronchus morphogenesis
0.80	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
0.79	GO:0097500	receptor localization to non-motile cilium
0.79	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
0.79	GO:1903546	protein localization to photoreceptor outer segment
0.79	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning
0.78	GO:0048702	embryonic neurocranium morphogenesis
0.77	GO:0061548	ganglion development
0.75	GO:0031076	embryonic camera-type eye development
0.74	GO:0042733	embryonic digit morphogenesis

0.67	GO:0035091	phosphatidylinositol binding
0.65	GO:0032403	protein complex binding
0.63	GO:0019899	enzyme binding
0.50	GO:0003700	DNA binding transcription factor activity

0.75	GO:0097546	ciliary base
0.75	GO:0030991	intraciliary transport particle A
0.71	GO:0005930	axoneme
0.64	GO:0005730	nucleolus
0.59	GO:0005576	extracellular region
0.50	GO:0005886	plasma membrane

sp|O75387|LAT3_HUMAN
Large neutral amino acids transporter small subunit 3
Search

SLC43A1

0.91	Solute carrier family 43 (amino acid system L transporter), member 1b

0.63	GO:0015804	neutral amino acid transport
0.61	GO:1902475	L-alpha-amino acid transmembrane transport
0.45	GO:0072015	glomerular visceral epithelial cell development

0.64

GO:0015171

amino acid transmembrane transporter activity

0.46

GO:0005887

integral component of plasma membrane

sp|O75388|GPR32_HUMAN
Probable G-protein coupled receptor 32
Search

0.85	Formyl peptide receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.56	GO:0002430	complement receptor mediated signaling pathway
0.54	GO:0006935	chemotaxis
0.51	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.51	GO:0070887	cellular response to chemical stimulus
0.51	GO:0050900	leukocyte migration
0.51	GO:0006954	inflammatory response
0.48	GO:0010033	response to organic substance
0.45	GO:0071675	regulation of mononuclear cell migration
0.44	GO:0002690	positive regulation of leukocyte chemotaxis

0.72	GO:0004930	G-protein coupled receptor activity
0.64	GO:0001653	peptide receptor activity
0.56	GO:0004875	complement receptor activity
0.48	GO:0004896	cytokine receptor activity
0.45	GO:0005124	scavenger receptor binding
0.39	GO:0038024	cargo receptor activity
0.39	GO:0019956	chemokine binding
0.36	GO:0030594	neurotransmitter receptor activity
0.35	GO:0001847	opsonin receptor activity
0.34	GO:0030165	PDZ domain binding

0.45	GO:0005887	integral component of plasma membrane
0.36	GO:0101003	ficolin-1-rich granule membrane
0.36	GO:0035579	specific granule membrane
0.36	GO:0070821	tertiary granule membrane
0.33	GO:0005829	cytosol

sp|O75390|CISY_HUMAN
Citrate synthase, mitochondrial
Search

0.45	Citrate synthase, mitochondrial

0.70	GO:0006101	citrate metabolic process
0.63	GO:0009060	aerobic respiration
0.45	GO:0005975	carbohydrate metabolic process
0.35	GO:0014823	response to activity
0.34	GO:0006107	oxaloacetate metabolic process
0.34	GO:0006084	acetyl-CoA metabolic process

0.76	GO:0004108	citrate (Si)-synthase activity
0.34	GO:0003723	RNA binding

0.52	GO:0005759	mitochondrial matrix
0.36	GO:0070062	extracellular exosome
0.34	GO:0005634	nucleus

0.76

EC:2.3.3.1

GO:0004108

sp|O75391|SPAG7_HUMAN
Sperm-associated antigen 7
Search

SPAG7

0.97	Sperm-associated antigen 7

0.32

GO:0009405

pathogenesis

0.51

GO:0003676

nucleic acid binding

0.50	GO:0005634	nucleus
0.30	GO:0044425	membrane part

sp|O75394|RM33_HUMAN
39S ribosomal protein L33, mitochondrial
Search

MRPL33

0.44	Mitochondrial ribosomal protein L33

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.38	GO:0043624	cellular protein complex disassembly

0.63

GO:0003735

structural constituent of ribosome

0.62	GO:0005762	mitochondrial large ribosomal subunit
0.38	GO:0031966	mitochondrial membrane
0.38	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

sp|O75396|SC22B_HUMAN
Vesicle-trafficking protein SEC22b
Search

SEC22B

0.94	SEC22 vesicle trafficking protein homolog B (S. cerevisiae)

0.67	GO:0016192	vesicle-mediated transport
0.56	GO:1902902	negative regulation of autophagosome assembly
0.52	GO:0045732	positive regulation of protein catabolic process
0.47	GO:0090174	organelle membrane fusion
0.46	GO:0016050	vesicle organization
0.43	GO:0032940	secretion by cell
0.43	GO:0046907	intracellular transport
0.39	GO:0015031	protein transport
0.35	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.35	GO:0051650	establishment of vesicle localization

0.47	GO:0000149	SNARE binding
0.47	GO:0005484	SNAP receptor activity

0.55	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.52	GO:0012507	ER to Golgi transport vesicle membrane
0.48	GO:0005789	endoplasmic reticulum membrane
0.48	GO:0005794	Golgi apparatus
0.48	GO:0031201	SNARE complex
0.43	GO:0042470	melanosome
0.35	GO:0030670	phagocytic vesicle membrane
0.34	GO:0070382	exocytic vesicle
0.30	GO:0016021	integral component of membrane

sp|O75398|DEAF1_HUMAN
Deformed epidermal autoregulatory factor 1 homolog
Search

DEAF1

0.89	DEAF1 transcription factor

0.73	GO:0033599	regulation of mammary gland epithelial cell proliferation
0.73	GO:0001662	behavioral fear response
0.72	GO:0008542	visual learning
0.70	GO:0001843	neural tube closure
0.69	GO:0048706	embryonic skeletal system development
0.64	GO:0000122	negative regulation of transcription by RNA polymerase II
0.63	GO:0006366	transcription by RNA polymerase II
0.61	GO:0045893	positive regulation of transcription, DNA-templated

0.68	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.64	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding

0.68	GO:0001650	fibrillar center
0.63	GO:0005667	transcription factor complex
0.30	GO:0016020	membrane

sp|O75400|PR40A_HUMAN
Pre-mRNA-processing factor 40 homolog A
Search

PRPF40A

0.94	Pre-mRNA-processing factor 40 like protein A

0.76	GO:0032465	regulation of cytokinesis
0.75	GO:0016477	cell migration
0.69	GO:0007010	cytoskeleton organization
0.67	GO:0008360	regulation of cell shape
0.59	GO:0000398	mRNA splicing, via spliceosome
0.37	GO:0051301	cell division
0.37	GO:0007049	cell cycle

0.84	GO:0070064	proline-rich region binding
0.49	GO:0003723	RNA binding

0.82	GO:0016363	nuclear matrix
0.79	GO:0016607	nuclear speck
0.67	GO:0005829	cytosol
0.64	GO:0071004	U2-type prespliceosome
0.63	GO:0005685	U1 snRNP
0.30	GO:0016020	membrane

sp|O75409|HYPM_HUMAN
Huntingtin-interacting protein M
Search

HYPM

0.96	Huntingtin-interacting protein M

0.51

GO:0006342

chromatin silencing

0.74	GO:0046982	protein heterodimerization activity
0.40	GO:0003677	DNA binding

0.49

GO:0000790

nuclear chromatin

sp|O75410|TACC1_HUMAN
Transforming acidic coiled-coil-containing protein 1
Search

TACC1

0.92	Transforming acidic coiled-coil-containing protein 1

0.85	GO:0021987	cerebral cortex development
0.80	GO:0008283	cell proliferation
0.76	GO:0000226	microtubule cytoskeleton organization
0.53	GO:0007097	nuclear migration
0.51	GO:0032886	regulation of microtubule-based process
0.49	GO:0022008	neurogenesis
0.47	GO:0051301	cell division
0.47	GO:0007049	cell cycle

0.49

GO:0019904

protein domain specific binding

0.70	GO:0015630	microtubule cytoskeleton
0.54	GO:0030496	midbody
0.48	GO:0005737	cytoplasm
0.48	GO:0044430	cytoskeletal part
0.44	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|O75414|NDK6_HUMAN
Nucleoside diphosphate kinase 6
Search

NME6

0.47	Nucleoside diphosphate kinase

0.77	GO:0006228	UTP biosynthetic process
0.77	GO:0006183	GTP biosynthetic process
0.73	GO:0046036	CTP metabolic process
0.68	GO:0006165	nucleoside diphosphate phosphorylation
0.39	GO:0030308	negative regulation of cell growth
0.39	GO:0045839	negative regulation of mitotic nuclear division
0.36	GO:0015949	nucleobase-containing small molecule interconversion
0.35	GO:0006915	apoptotic process

0.77	GO:0004550	nucleoside diphosphate kinase activity
0.51	GO:0032559	adenyl ribonucleotide binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0046872	metal ion binding

0.47	GO:0005739	mitochondrion
0.34	GO:0005829	cytosol

0.77

EC:2.7.4.6

GO:0004550

sp|O75417|DPOLQ_HUMAN
DNA polymerase theta
Search

POLQ

0.87	DNA polymerase theta

0.70	GO:0006261	DNA-dependent DNA replication
0.65	GO:0071897	DNA biosynthetic process
0.65	GO:0097681	double-strand break repair via alternative nonhomologous end joining
0.63	GO:2000042	negative regulation of double-strand break repair via homologous recombination
0.60	GO:0016446	somatic hypermutation of immunoglobulin genes
0.56	GO:0051260	protein homooligomerization
0.53	GO:0006284	base-excision repair
0.37	GO:0010501	RNA secondary structure unwinding
0.37	GO:0000724	double-strand break repair via homologous recombination
0.34	GO:0032259	methylation

0.71	GO:0003887	DNA-directed DNA polymerase activity
0.64	GO:0051575	5'-deoxyribose-5-phosphate lyase activity
0.59	GO:0043142	single-stranded DNA-dependent ATPase activity
0.56	GO:0003682	chromatin binding
0.53	GO:0003677	DNA binding
0.52	GO:0032559	adenyl ribonucleotide binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0008409	5'-3' exonuclease activity
0.38	GO:0042802	identical protein binding

0.42	GO:0005634	nucleus
0.38	GO:0031974	membrane-enclosed lumen
0.38	GO:0005737	cytoplasm
0.36	GO:0043232	intracellular non-membrane-bounded organelle
0.36	GO:0044446	intracellular organelle part
0.34	GO:0012506	vesicle membrane
0.33	GO:0097708	intracellular vesicle
0.33	GO:0012505	endomembrane system
0.30	GO:0031224	intrinsic component of membrane

0.71

EC:2.7.7.7

GO:0003887

sp|O75419|CDC45_HUMAN
Cell division control protein 45 homolog
Search

CDC45

0.90	Cell division control protein 45

0.75	GO:0006270	DNA replication initiation
0.55	GO:0051301	cell division
0.50	GO:1902977	mitotic DNA replication preinitiation complex assembly
0.49	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
0.49	GO:1902299	pre-replicative complex assembly involved in cell cycle DNA replication
0.49	GO:0031938	regulation of chromatin silencing at telomere
0.48	GO:0000727	double-strand break repair via break-induced replication
0.43	GO:0032392	DNA geometric change
0.35	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
0.35	GO:0000076	DNA replication checkpoint

0.46	GO:0043138	3'-5' DNA helicase activity
0.46	GO:0003682	chromatin binding
0.46	GO:0003688	DNA replication origin binding
0.44	GO:0003697	single-stranded DNA binding
0.35	GO:0008270	zinc ion binding
0.34	GO:0005515	protein binding

0.49	GO:0005813	centrosome
0.49	GO:0005656	nuclear pre-replicative complex
0.48	GO:0031298	replication fork protection complex
0.48	GO:0031261	DNA replication preinitiation complex
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|O75420|GGYF1_HUMAN
GRB10-interacting GYF protein 1
Search

GIGYF1

0.93	PERQ amino acid-rich with GYF domain-containing protein 1

0.86	GO:0048009	insulin-like growth factor receptor signaling pathway
0.33	GO:0061157	mRNA destabilization
0.33	GO:0048873	homeostasis of number of cells within a tissue
0.33	GO:0050881	musculoskeletal movement
0.33	GO:0021522	spinal cord motor neuron differentiation
0.33	GO:0031571	mitotic G1 DNA damage checkpoint
0.33	GO:0050885	neuromuscular process controlling balance
0.33	GO:0035264	multicellular organism growth
0.33	GO:0008344	adult locomotory behavior
0.33	GO:0007631	feeding behavior

0.40	GO:0005515	protein binding
0.33	GO:0005509	calcium ion binding

0.59	GO:0043234	protein complex
0.33	GO:1990635	proximal dendrite
0.33	GO:0043204	perikaryon
0.33	GO:0010494	cytoplasmic stress granule
0.33	GO:0005768	endosome
0.32	GO:0005794	Golgi apparatus
0.32	GO:0005783	endoplasmic reticulum
0.32	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O75425|MSPD3_HUMAN
Motile sperm domain-containing protein 3
Search

MOSPD3

0.96	Motile sperm domain-containing protein 3

0.57	GO:0007507	heart development
0.38	GO:0000122	negative regulation of transcription by RNA polymerase II
0.38	GO:0045944	positive regulation of transcription by RNA polymerase II

0.63	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0005634	nucleus
0.34	GO:0005856	cytoskeleton
0.30	GO:0016021	integral component of membrane

sp|O75426|FBX24_HUMAN
F-box only protein 24
Search

FBXO24

0.97	F-box only protein 24

0.65

GO:0016567

protein ubiquitination

0.66	GO:0004842	ubiquitin-protein transferase activity
0.57	GO:0005515	protein binding

0.68

GO:0000151

ubiquitin ligase complex

0.66

GO:0004842

sp|O75427|LRCH4_HUMAN
Leucine-rich repeat and calponin homology domain-containing protein 4
Search

LRCH4

0.92	Leucine-rich repeat and calponin like proteiny domain-containing protein 4

0.57	GO:0045199	maintenance of epithelial cell apical/basal polarity
0.46	GO:0007165	signal transduction
0.43	GO:2000405	negative regulation of T cell migration
0.42	GO:1990868	response to chemokine
0.42	GO:0034260	negative regulation of GTPase activity
0.40	GO:0071345	cellular response to cytokine stimulus
0.38	GO:0045892	negative regulation of transcription, DNA-templated
0.37	GO:0007399	nervous system development

0.38

GO:0005515

protein binding

0.65	GO:0016605	PML body
0.54	GO:0016323	basolateral plasma membrane
0.39	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|O75431|MTX2_HUMAN
Metaxin-2
Search

MTX2

0.87	Metaxin-2 protein 2

0.78

GO:0006626

protein targeting to mitochondrion

0.33	GO:0005515	protein binding
0.32	GO:0003723	RNA binding

0.77	GO:0005741	mitochondrial outer membrane
0.50	GO:0005730	nucleolus
0.30	GO:0016021	integral component of membrane

sp|O75436|VP26A_HUMAN
Vacuolar protein sorting-associated protein 26A
Search

VPS26A

0.97	Vacuolar protein sorting-associated protein 26A-A

0.61	GO:0007165	signal transduction
0.54	GO:1990126	retrograde transport, endosome to plasma membrane
0.54	GO:0042147	retrograde transport, endosome to Golgi
0.43	GO:0006886	intracellular protein transport
0.35	GO:0016241	regulation of macroautophagy
0.34	GO:0198738	cell-cell signaling by wnt
0.34	GO:0045053	protein retention in Golgi apparatus
0.33	GO:0071346	cellular response to interferon-gamma

0.44	GO:0008565	protein transporter activity
0.34	GO:0005515	protein binding
0.34	GO:0004386	helicase activity

0.55	GO:0097422	tubular endosome
0.54	GO:0030904	retromer complex
0.52	GO:0005769	early endosome
0.51	GO:0010008	endosome membrane
0.50	GO:0005764	lysosome
0.48	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome
0.33	GO:0045335	phagocytic vesicle
0.33	GO:0005770	late endosome

sp|O75437|ZN254_HUMAN
Zinc finger protein 254
Search

0.74	Zinc finger protein 726

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.40	GO:0006351	transcription, DNA-templated
0.34	GO:0035108	limb morphogenesis
0.30	GO:0010558	negative regulation of macromolecule biosynthetic process
0.30	GO:0045934	negative regulation of nucleobase-containing compound metabolic process
0.30	GO:0031327	negative regulation of cellular biosynthetic process

0.52	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.37	GO:0005515	protein binding
0.30	GO:0003700	DNA binding transcription factor activity

0.45	GO:0005622	intracellular
0.39	GO:0043227	membrane-bounded organelle
0.30	GO:0016020	membrane

sp|O75438|NDUB1_HUMAN
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
Search

NDUFB1

0.97	Mitochondrial NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

0.56	GO:0032981	mitochondrial respiratory chain complex I assembly
0.53	GO:0055114	oxidation-reduction process
0.35	GO:0006119	oxidative phosphorylation

0.69	GO:0003954	NADH dehydrogenase activity
0.36	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

0.61	GO:0005739	mitochondrion
0.55	GO:0045271	respiratory chain complex I
0.49	GO:1990204	oxidoreductase complex
0.47	GO:0016607	nuclear speck
0.45	GO:0019866	organelle inner membrane
0.41	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.69

EC:1.6.99.3

GO:0003954

sp|O75439|MPPB_HUMAN
Mitochondrial-processing peptidase subunit beta
Search

PMPCB

0.84	Mitochondrial-processing peptidase subunit beta

0.83	GO:0006627	protein processing involved in protein targeting to mitochondrion
0.45	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c
0.41	GO:0009060	aerobic respiration
0.35	GO:0006851	mitochondrial calcium ion transmembrane transport

0.70	GO:0004222	metalloendopeptidase activity
0.54	GO:0046872	metal ion binding

0.85	GO:0017087	mitochondrial processing peptidase complex
0.48	GO:0005750	mitochondrial respiratory chain complex III
0.30	GO:0016021	integral component of membrane

0.70

GO:0004222

sp|O75443|TECTA_HUMAN
Alpha-tectorin
Search

TECTA

0.80	Tectorin alpha

0.82	GO:0007605	sensory perception of sound
0.76	GO:0007160	cell-matrix adhesion
0.53	GO:0035889	otolith tethering
0.34	GO:0006501	C-terminal protein lipidation
0.33	GO:0008610	lipid biosynthetic process
0.32	GO:0055114	oxidation-reduction process

0.82	GO:0005201	extracellular matrix structural constituent
0.33	GO:0005506	iron ion binding
0.33	GO:0005515	protein binding
0.32	GO:0016491	oxidoreductase activity

0.75	GO:0005578	proteinaceous extracellular matrix
0.39	GO:0031225	anchored component of membrane
0.35	GO:0070062	extracellular exosome
0.35	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.32

GO:0016491

sp|O75444|MAF_HUMAN
Transcription factor Maf
Search

MAF

0.86	V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba

0.59	GO:0070306	lens fiber cell differentiation
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:0010468	regulation of gene expression
0.55	GO:0006351	transcription, DNA-templated
0.55	GO:0032330	regulation of chondrocyte differentiation
0.54	GO:0001816	cytokine production
0.53	GO:0048839	inner ear development
0.51	GO:1902680	positive regulation of RNA biosynthetic process
0.50	GO:0048468	cell development

0.61	GO:0003700	DNA binding transcription factor activity
0.53	GO:0003677	DNA binding
0.40	GO:0001067	regulatory region nucleic acid binding
0.39	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.38	GO:0005737	cytoplasm
0.36	GO:0000785	chromatin
0.36	GO:0043233	organelle lumen
0.35	GO:0042025	host cell nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|O75445|USH2A_HUMAN
Usherin
Search

USH2A

0.64	Usher syndrome 2A (autosomal recessive, mild)

0.57	GO:0007423	sensory organ development
0.56	GO:0030182	neuron differentiation
0.55	GO:0048496	maintenance of animal organ identity
0.53	GO:0045494	photoreceptor cell maintenance
0.52	GO:0009913	epidermal cell differentiation
0.51	GO:0007605	sensory perception of sound
0.50	GO:0050953	sensory perception of light stimulus
0.48	GO:0009887	animal organ morphogenesis
0.47	GO:0048468	cell development
0.44	GO:0045184	establishment of protein localization

0.52	GO:0017022	myosin binding
0.51	GO:0005518	collagen binding
0.48	GO:0042803	protein homodimerization activity
0.33	GO:0003707	steroid hormone receptor activity
0.33	GO:0005044	scavenger receptor activity
0.32	GO:0043565	sequence-specific DNA binding
0.32	GO:0008270	zinc ion binding
0.32	GO:0003700	DNA binding transcription factor activity

0.56	GO:0060171	stereocilium membrane
0.56	GO:0002142	stereocilia ankle link complex
0.56	GO:1990696	USH2 complex
0.55	GO:1990075	periciliary membrane compartment
0.53	GO:0001917	photoreceptor inner segment
0.53	GO:0032391	photoreceptor connecting cilium
0.51	GO:0036064	ciliary basal body
0.51	GO:0005604	basement membrane
0.51	GO:0016324	apical plasma membrane
0.39	GO:0043195	terminal bouton

sp|O75446|SAP30_HUMAN
Histone deacetylase complex subunit SAP30
Search

SAP30

0.93	Histone deacetylase complex subunit SAP30

0.73	GO:0035914	skeletal muscle cell differentiation
0.67	GO:0000122	negative regulation of transcription by RNA polymerase II
0.60	GO:0016575	histone deacetylation
0.50	GO:0001947	heart looping
0.38	GO:0006351	transcription, DNA-templated
0.38	GO:0000183	chromatin silencing at rDNA
0.37	GO:0006486	protein glycosylation

0.69	GO:0003714	transcription corepressor activity
0.62	GO:0044378	non-sequence-specific DNA binding, bending
0.61	GO:0004407	histone deacetylase activity
0.59	GO:0010314	phosphatidylinositol-5-phosphate binding
0.57	GO:0031491	nucleosome binding
0.55	GO:0042393	histone binding
0.47	GO:0008270	zinc ion binding
0.40	GO:0070273	phosphatidylinositol-4-phosphate binding
0.40	GO:0032266	phosphatidylinositol-3-phosphate binding
0.36	GO:0030246	carbohydrate binding

0.74	GO:0000118	histone deacetylase complex
0.52	GO:0005730	nucleolus
0.37	GO:0000139	Golgi membrane
0.37	GO:0000790	nuclear chromatin
0.30	GO:0031224	intrinsic component of membrane

0.61

EC:3.5.1.98

GO:0004407

sp|O75448|MED24_HUMAN
Mediator of RNA polymerase II transcription subunit 24
Search

MED24

0.93	Mediator of RNA polymerase II transcription subunit 24

0.70	GO:0019827	stem cell population maintenance
0.66	GO:0006366	transcription by RNA polymerase II
0.65	GO:0061453	interstitial cell of Cajal differentiation
0.61	GO:0046549	retinal cone cell development
0.60	GO:0048484	enteric nervous system development
0.59	GO:0048538	thymus development
0.55	GO:0006357	regulation of transcription by RNA polymerase II
0.50	GO:0030521	androgen receptor signaling pathway
0.47	GO:0051291	protein heterooligomerization
0.45	GO:0045893	positive regulation of transcription, DNA-templated

0.60	GO:0001104	RNA polymerase II transcription cofactor activity
0.50	GO:0046966	thyroid hormone receptor binding
0.47	GO:0003713	transcription coactivator activity
0.45	GO:0004402	histone acetyltransferase activity
0.44	GO:0061630	ubiquitin protein ligase activity
0.42	GO:0004872	receptor activity
0.41	GO:0042809	vitamin D receptor binding

0.72	GO:0016592	mediator complex
0.44	GO:0000151	ubiquitin ligase complex

0.45

GO:0004402

sp|O75449|KTNA1_HUMAN
Katanin p60 ATPase-containing subunit A1
Search

KATNA1

0.79	Katanin catalytic subunit A1

0.81	GO:0051013	microtubule severing
0.63	GO:0051301	cell division
0.62	GO:0007049	cell cycle
0.43	GO:0031122	cytoplasmic microtubule organization
0.42	GO:0048675	axon extension
0.42	GO:0035329	hippo signaling
0.37	GO:0036211	protein modification process
0.36	GO:0001764	neuron migration
0.36	GO:0044267	cellular protein metabolic process
0.36	GO:0001578	microtubule bundle formation

0.82	GO:0008568	microtubule-severing ATPase activity
0.71	GO:0008017	microtubule binding
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0046982	protein heterodimerization activity
0.39	GO:0004674	protein serine/threonine kinase activity
0.36	GO:0070840	dynein complex binding
0.35	GO:0004842	ubiquitin-protein transferase activity
0.34	GO:0042802	identical protein binding

0.74	GO:0000922	spindle pole
0.71	GO:0005813	centrosome
0.68	GO:0005874	microtubule
0.64	GO:0030496	midbody
0.56	GO:0072686	mitotic spindle
0.47	GO:0005737	cytoplasm
0.40	GO:0005634	nucleus
0.38	GO:0031463	Cul3-RING ubiquitin ligase complex
0.36	GO:0005811	lipid droplet
0.36	GO:0030424	axon

0.82	EC:3.6.4.3	GO:0008568
0.35	KEGG:R03876	GO:0004842

sp|O75452|RDH16_HUMAN
Retinol dehydrogenase 16
Search

0.94	Retinol dehydrogenase similar protein 2

0.51	GO:0055114	oxidation-reduction process
0.47	GO:0001523	retinoid metabolic process
0.42	GO:0034754	cellular hormone metabolic process
0.42	GO:0008202	steroid metabolic process
0.41	GO:0016102	diterpenoid biosynthetic process
0.38	GO:0072330	monocarboxylic acid biosynthetic process
0.37	GO:0034308	primary alcohol metabolic process
0.36	GO:0017144	drug metabolic process
0.34	GO:0042446	hormone biosynthetic process
0.34	GO:0042447	hormone catabolic process

0.53	GO:0004745	retinol dehydrogenase activity
0.43	GO:0016229	steroid dehydrogenase activity
0.36	GO:0042803	protein homodimerization activity
0.34	GO:0009055	electron transfer activity

0.40	GO:0005783	endoplasmic reticulum
0.37	GO:0031090	organelle membrane
0.36	GO:0005769	early endosome
0.36	GO:0044446	intracellular organelle part
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.35	GO:0098805	whole membrane
0.35	GO:0043233	organelle lumen
0.30	GO:0016021	integral component of membrane

0.53

EC:1.1.1.105

GO:0004745

sp|O75459|PAGE1_HUMAN
P antigen family member 1
Search

0.96	G antigen 4

0.63

GO:0006968

cellular defense response

0.58

GO:0005515

protein binding

sp|O75460|ERN1_HUMAN
Serine/threonine-protein kinase/endoribonuclease IRE1
Search

ERN1

0.89	Endoplasmic reticulum to nucleus signaling 1

0.69	GO:0006397	mRNA processing
0.69	GO:0090501	RNA phosphodiester bond hydrolysis
0.63	GO:0006468	protein phosphorylation
0.61	GO:0006987	activation of signaling protein activity involved in unfolded protein response
0.60	GO:0036498	IRE1-mediated unfolded protein response
0.60	GO:1901142	insulin metabolic process
0.60	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response
0.59	GO:1904707	positive regulation of vascular smooth muscle cell proliferation
0.59	GO:0001935	endothelial cell proliferation
0.59	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

0.69	GO:0004540	ribonuclease activity
0.63	GO:0004672	protein kinase activity
0.59	GO:0005161	platelet-derived growth factor receptor binding
0.59	GO:0051879	Hsp90 protein binding
0.59	GO:0030544	Hsp70 protein binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0042803	protein homodimerization activity

0.62	GO:1990630	IRE1-RACK1-PP2A complex
0.61	GO:1990597	AIP1-IRE1 complex
0.61	GO:1990604	IRE1-TRAF2-ASK1 complex
0.56	GO:0005637	nuclear inner membrane
0.53	GO:0030176	integral component of endoplasmic reticulum membrane
0.45	GO:0005739	mitochondrion
0.37	GO:1990332	Ire1 complex

sp|O75461|E2F6_HUMAN
Transcription factor E2F6
Search

E2F6

0.97	Transcription factor E2F6 isoform B

0.57	GO:0006351	transcription, DNA-templated
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.52	GO:0000082	G1/S transition of mitotic cell cycle
0.48	GO:0048519	negative regulation of biological process
0.46	GO:1990086	lens fiber cell apoptotic process
0.44	GO:1902680	positive regulation of RNA biosynthetic process
0.44	GO:1903670	regulation of sprouting angiogenesis
0.44	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator

0.67	GO:0046983	protein dimerization activity
0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.47	GO:0001047	core promoter binding
0.41	GO:0008134	transcription factor binding
0.35	GO:0051539	4 iron, 4 sulfur cluster binding
0.35	GO:0003714	transcription corepressor activity
0.33	GO:0016740	transferase activity
0.32	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

0.74	GO:0005667	transcription factor complex
0.61	GO:0005634	nucleus
0.49	GO:0034708	methyltransferase complex
0.46	GO:0031974	membrane-enclosed lumen
0.45	GO:0044446	intracellular organelle part
0.34	GO:0032993	protein-DNA complex
0.33	GO:0005694	chromosome
0.32	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:2

GO:0016740

sp|O75462|CRLF1_HUMAN
Cytokine receptor-like factor 1
Search

CRLF1

0.97	Class I helical cytokine receptor number 1

0.85	GO:2000672	negative regulation of motor neuron apoptotic process
0.82	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
0.81	GO:0001657	ureteric bud development
0.75	GO:0008284	positive regulation of cell proliferation
0.72	GO:0010469	regulation of receptor activity
0.44	GO:0070106	interleukin-27-mediated signaling pathway

0.85	GO:0005127	ciliary neurotrophic factor receptor binding
0.79	GO:0019955	cytokine binding
0.76	GO:0005125	cytokine activity
0.71	GO:0046982	protein heterodimerization activity

0.85	GO:0097058	CRLF-CLCF1 complex
0.39	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O75467|Z324A_HUMAN
Zinc finger protein 324A
Search

0.95	LOW QUALITY PROTEIN: zinc finger protein 324A

0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.36	GO:0006351	transcription, DNA-templated
0.32	GO:0006468	protein phosphorylation

0.52	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.35	GO:0003700	DNA binding transcription factor activity
0.32	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.44	GO:0005622	intracellular
0.35	GO:0043227	membrane-bounded organelle

sp|O75469|NR1I2_HUMAN
Nuclear receptor subfamily 1 group I member 2
Search

NR1I2

0.94	Nuclear receptor subfamily 1 group I member 2

0.77	GO:0043401	steroid hormone mediated signaling pathway
0.69	GO:0030522	intracellular receptor signaling pathway
0.66	GO:0042738	exogenous drug catabolic process
0.61	GO:0046618	drug export
0.60	GO:0006366	transcription by RNA polymerase II
0.58	GO:0042908	xenobiotic transport
0.58	GO:0045944	positive regulation of transcription by RNA polymerase II
0.57	GO:0006805	xenobiotic metabolic process
0.55	GO:0045892	negative regulation of transcription, DNA-templated
0.40	GO:0009636	response to toxic substance

0.78	GO:0003707	steroid hormone receptor activity
0.71	GO:0004879	nuclear receptor activity
0.61	GO:0043565	sequence-specific DNA binding
0.61	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.60	GO:0008270	zinc ion binding
0.59	GO:0001012	RNA polymerase II regulatory region DNA binding
0.56	GO:0003690	double-stranded DNA binding
0.44	GO:0008144	drug binding
0.37	GO:0003713	transcription coactivator activity
0.36	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.58	GO:0045111	intermediate filament cytoskeleton
0.54	GO:0043233	organelle lumen
0.48	GO:0044446	intracellular organelle part
0.40	GO:0005829	cytosol

sp|O75473|LGR5_HUMAN
Leucine-rich repeat-containing G-protein coupled receptor 5
Search

LGR5

0.89	Leucine-rich repeat-containing G-protein coupled receptor 5

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.48	GO:0030177	positive regulation of Wnt signaling pathway
0.46	GO:0060828	regulation of canonical Wnt signaling pathway
0.46	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis
0.45	GO:0001942	hair follicle development
0.44	GO:0009994	oocyte differentiation
0.44	GO:0048839	inner ear development
0.42	GO:0042127	regulation of cell proliferation
0.38	GO:1990523	bone regeneration
0.37	GO:0030335	positive regulation of cell migration

0.84	GO:0016500	protein-hormone receptor activity
0.69	GO:0004930	G-protein coupled receptor activity
0.35	GO:0005515	protein binding

0.48	GO:0032588	trans-Golgi network membrane
0.42	GO:0005887	integral component of plasma membrane
0.36	GO:0031982	vesicle

sp|O75474|FRAT2_HUMAN
GSK-3-binding protein FRAT2
Search

FRAT2

0.96	Frequently rearranged in advanced T-cell lymphomas

0.69	GO:0016055	Wnt signaling pathway
0.44	GO:0007275	multicellular organism development
0.43	GO:0043241	protein complex disassembly
0.42	GO:0008283	cell proliferation
0.39	GO:0006611	protein export from nucleus
0.38	GO:0016310	phosphorylation
0.34	GO:0097466	ubiquitin-dependent glycoprotein ERAD pathway
0.34	GO:0006491	N-glycan processing
0.34	GO:0030968	endoplasmic reticulum unfolded protein response

0.39	GO:0016301	kinase activity
0.38	GO:0005515	protein binding
0.34	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
0.33	GO:0005509	calcium ion binding

0.52	GO:0005829	cytosol
0.44	GO:0043231	intracellular membrane-bounded organelle
0.33	GO:0012505	endomembrane system
0.30	GO:0016020	membrane

0.34	EC:3.2.1.113	GO:0004571
0.34	KEGG:R05982 KEGG:R06722	GO:0004571

sp|O75475|PSIP1_HUMAN
PC4 and SFRS1-interacting protein
Search

PSIP1

0.96	Lens epithelium-derived growth factor

0.85	GO:0000395	mRNA 5'-splice site recognition
0.74	GO:0009408	response to heat
0.70	GO:0006979	response to oxidative stress
0.54	GO:0006366	transcription by RNA polymerase II
0.54	GO:0045944	positive regulation of transcription by RNA polymerase II
0.39	GO:0075713	establishment of integrated proviral latency
0.39	GO:0051169	nuclear transport

0.63	GO:0097100	supercoiled DNA binding
0.60	GO:0001105	RNA polymerase II transcription coactivator activity
0.60	GO:0033613	activating transcription factor binding
0.55	GO:0003682	chromatin binding
0.38	GO:0003723	RNA binding

0.68	GO:0005654	nucleoplasm
0.60	GO:0035327	transcriptionally active chromatin
0.59	GO:0005720	nuclear heterochromatin
0.46	GO:0034399	nuclear periphery
0.41	GO:0005730	nucleolus
0.37	GO:0005829	cytosol
0.33	GO:0019013	viral nucleocapsid
0.33	GO:0030529	intracellular ribonucleoprotein complex

sp|O75477|ERLN1_HUMAN
Erlin-1
Search

ERLIN1

0.95	ER lipid raft associated 1

0.82	GO:0030433	ubiquitin-dependent ERAD pathway
0.66	GO:0045541	negative regulation of cholesterol biosynthetic process
0.65	GO:0032933	SREBP signaling pathway
0.62	GO:0045717	negative regulation of fatty acid biosynthetic process
0.44	GO:0008203	cholesterol metabolic process
0.40	GO:0007252	I-kappaB phosphorylation
0.35	GO:1902741	positive regulation of interferon-alpha secretion
0.35	GO:0038061	NIK/NF-kappaB signaling
0.35	GO:0071276	cellular response to cadmium ion
0.35	GO:0032088	negative regulation of NF-kappaB transcription factor activity

0.79	GO:0031625	ubiquitin protein ligase binding
0.60	GO:0015485	cholesterol binding
0.40	GO:0008384	IkappaB kinase activity
0.35	GO:0097110	scaffold protein binding
0.34	GO:0070330	aromatase activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0042803	protein homodimerization activity
0.34	GO:0008233	peptidase activity

0.70	GO:0005783	endoplasmic reticulum
0.56	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.54	GO:0031984	organelle subcompartment
0.49	GO:0045121	membrane raft
0.47	GO:0043234	protein complex
0.45	GO:0005829	cytosol
0.40	GO:0005886	plasma membrane
0.35	GO:0070062	extracellular exosome
0.33	GO:0005654	nucleoplasm
0.30	GO:0016021	integral component of membrane

0.40

EC:2.7.11.10

GO:0008384

sp|O75478|TAD2A_HUMAN
Transcriptional adapter 2-alpha
Search

TADA2A

0.80	Transcriptional adapter

0.81	GO:0035065	regulation of histone acetylation
0.68	GO:0006357	regulation of transcription by RNA polymerase II
0.58	GO:0090043	regulation of tubulin deacetylation
0.56	GO:0031063	regulation of histone deacetylation
0.55	GO:0006351	transcription, DNA-templated
0.52	GO:0031647	regulation of protein stability
0.50	GO:0000278	mitotic cell cycle
0.49	GO:0001932	regulation of protein phosphorylation
0.49	GO:2000758	positive regulation of peptidyl-lysine acetylation
0.48	GO:0031058	positive regulation of histone modification

0.76	GO:0003713	transcription coactivator activity
0.55	GO:0003677	DNA binding
0.47	GO:0004402	histone acetyltransferase activity
0.46	GO:0003682	chromatin binding
0.40	GO:0003700	DNA binding transcription factor activity
0.34	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.53	GO:0031248	protein acetyltransferase complex
0.53	GO:0072686	mitotic spindle
0.49	GO:0031974	membrane-enclosed lumen
0.45	GO:0043234	protein complex
0.37	GO:0005694	chromosome
0.30	GO:0016020	membrane

0.47

GO:0004402

sp|O75486|SUPT3_HUMAN
Transcription initiation protein SPT3 homolog
Search

SUPT3H

0.89	Suppressor of Ty 3

0.76	GO:0006366	transcription by RNA polymerase II
0.52	GO:0043966	histone H3 acetylation
0.52	GO:0016578	histone deubiquitination
0.41	GO:2001141	regulation of RNA biosynthetic process
0.36	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.36	GO:0010468	regulation of gene expression

0.74	GO:0046982	protein heterodimerization activity
0.50	GO:0004402	histone acetyltransferase activity
0.49	GO:0003713	transcription coactivator activity
0.36	GO:0003677	DNA binding

0.53	GO:0030914	STAGA complex
0.53	GO:0033276	transcription factor TFTC complex
0.42	GO:0000124	SAGA complex
0.41	GO:0005669	transcription factor TFIID complex

0.50

GO:0004402

sp|O75487|GPC4_HUMAN
Glypican-4
Search

GPC4

0.90	K-glypican

0.70	GO:0009966	regulation of signal transduction
0.44	GO:0016477	cell migration
0.41	GO:0060028	convergent extension involved in axis elongation
0.41	GO:0036342	post-anal tail morphogenesis
0.40	GO:0060027	convergent extension involved in gastrulation
0.40	GO:0030903	notochord development
0.40	GO:0001702	gastrulation with mouth forming second
0.40	GO:0009826	unidimensional cell growth
0.40	GO:0030166	proteoglycan biosynthetic process
0.40	GO:0051216	cartilage development

0.84	GO:0043395	heparan sulfate proteoglycan binding
0.37	GO:1904929	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway

0.83	GO:0046658	anchored component of plasma membrane
0.76	GO:0005578	proteinaceous extracellular matrix
0.53	GO:0009897	external side of plasma membrane
0.49	GO:0005615	extracellular space
0.40	GO:0005796	Golgi lumen
0.37	GO:0043202	lysosomal lumen
0.37	GO:1903561	extracellular vesicle
0.35	GO:0005634	nucleus
0.35	GO:0005887	integral component of plasma membrane

sp|O75489|NDUS3_HUMAN
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Search

NDUFS3

0.92	NADH:ubiquinone oxidoreductase core subunit S3

0.73	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway
0.72	GO:0030308	negative regulation of cell growth
0.64	GO:0072593	reactive oxygen species metabolic process
0.53	GO:0055114	oxidation-reduction process
0.46	GO:0006091	generation of precursor metabolites and energy

0.69

GO:0008137

NADH dehydrogenase (ubiquinone) activity

0.78	GO:0005747	mitochondrial respiratory chain complex I
0.76	GO:0043209	myelin sheath
0.68	GO:0016604	nuclear body

0.69

GO:0008137

sp|O75493|CAH11_HUMAN
Carbonic anhydrase-related protein 11
Search

CA11

0.94	Carbonic anhydrase XI

0.37	GO:0007420	brain development
0.37	GO:1903506	regulation of nucleic acid-templated transcription
0.37	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.37	GO:0010468	regulation of gene expression
0.34	GO:0007623	circadian rhythm

0.51	GO:0004089	carbonate dehydratase activity
0.38	GO:0003700	DNA binding transcription factor activity
0.34	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding

0.76	GO:0016323	basolateral plasma membrane
0.47	GO:0005576	extracellular region
0.33	GO:0005634	nucleus

0.51

EC:4.2.1.1

GO:0004089

sp|O75494|SRS10_HUMAN
Serine/arginine-rich splicing factor 10
Search

SRSF10

0.97	Serine and arginine rich splicing factor 10

0.79	GO:0043484	regulation of RNA splicing
0.54	GO:0006376	mRNA splice site selection
0.52	GO:0050684	regulation of mRNA processing
0.50	GO:0016482	cytosolic transport
0.49	GO:1903312	negative regulation of mRNA metabolic process
0.46	GO:0010629	negative regulation of gene expression
0.40	GO:0045292	mRNA cis splicing, via spliceosome
0.37	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.37	GO:0000244	spliceosomal tri-snRNP complex assembly
0.37	GO:0051028	mRNA transport

0.57	GO:0003723	RNA binding
0.38	GO:0050733	RS domain binding
0.37	GO:0051082	unfolded protein binding

0.50	GO:0016607	nuclear speck
0.45	GO:0005829	cytosol

sp|O75496|GEMI_HUMAN
Geminin
Search

GMNN

0.89	Geminin, DNA replication inhibitor

0.81	GO:0008156	negative regulation of DNA replication
0.77	GO:0045786	negative regulation of cell cycle
0.72	GO:0035563	positive regulation of chromatin binding
0.72	GO:0071163	DNA replication preinitiation complex assembly
0.65	GO:0090329	regulation of DNA-dependent DNA replication
0.64	GO:0048513	animal organ development
0.60	GO:0045892	negative regulation of transcription, DNA-templated
0.60	GO:0009653	anatomical structure morphogenesis
0.58	GO:0006461	protein complex assembly
0.50	GO:0070121	Kupffer's vesicle development

0.70	GO:0070491	repressing transcription factor binding
0.68	GO:0042826	histone deacetylase binding
0.67	GO:0003714	transcription corepressor activity
0.62	GO:0003682	chromatin binding

0.57	GO:0005829	cytosol
0.53	GO:0005634	nucleus

sp|O75503|CLN5_HUMAN
Ceroid-lipofuscinosis neuronal protein 5
Search

CLN5

0.97	Ceroid-lipofuscinosis neuronal protein 5

0.46	GO:1904426	positive regulation of GTP binding
0.45	GO:0007040	lysosome organization
0.43	GO:0042147	retrograde transport, endosome to Golgi
0.43	GO:0007035	vacuolar acidification
0.42	GO:0006465	signal peptide processing
0.42	GO:0007601	visual perception
0.41	GO:0007420	brain development
0.41	GO:0070085	glycosylation
0.40	GO:0022008	neurogenesis
0.37	GO:0071695	anatomical structure maturation

0.44	GO:0005537	mannose binding
0.36	GO:0005515	protein binding
0.33	GO:0016829	lyase activity

0.78	GO:0005764	lysosome
0.44	GO:0005775	vacuolar lumen
0.41	GO:0048471	perinuclear region of cytoplasm
0.41	GO:0098852	lytic vacuole membrane
0.40	GO:0005829	cytosol
0.39	GO:0005794	Golgi apparatus
0.39	GO:0005783	endoplasmic reticulum
0.37	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.33

EC:4

GO:0016829

sp|O75506|HSBP1_HUMAN
Heat shock factor-binding protein 1
Search

HSBP1

0.91	Heat shock factor-binding protein 1

0.72	GO:1903507	negative regulation of nucleic acid-templated transcription
0.48	GO:0035987	endodermal cell differentiation
0.40	GO:0014029	neural crest formation
0.38	GO:0007417	central nervous system development
0.38	GO:0006936	muscle contraction
0.35	GO:1900034	regulation of cellular response to heat
0.35	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.34	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
0.34	GO:0006357	regulation of transcription by RNA polymerase II
0.34	GO:0051492	regulation of stress fiber assembly

0.81	GO:0003714	transcription corepressor activity
0.47	GO:0042802	identical protein binding
0.34	GO:0005509	calcium ion binding
0.34	GO:0046983	protein dimerization activity

0.36	GO:0005634	nucleus
0.36	GO:0005856	cytoskeleton
0.33	GO:0031974	membrane-enclosed lumen
0.33	GO:0005886	plasma membrane
0.33	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|O75508|CLD11_HUMAN
Claudin-11
Search

CLDN11

0.67

Claudin

0.60	GO:0008366	axon ensheathment
0.58	GO:0007283	spermatogenesis
0.54	GO:0007155	cell adhesion
0.37	GO:0035622	intrahepatic bile duct development

0.62	GO:0005198	structural molecule activity
0.37	GO:0042802	identical protein binding

0.81	GO:0005923	bicellular tight junction
0.61	GO:0045178	basal part of cell
0.59	GO:0043209	myelin sheath
0.55	GO:0005886	plasma membrane
0.37	GO:0070062	extracellular exosome
0.30	GO:0044425	membrane part

sp|O75509|TNR21_HUMAN
Tumor necrosis factor receptor superfamily member 21
Search

TNFRSF21

0.97	LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 21

0.69	GO:2000663	negative regulation of interleukin-5 secretion
0.69	GO:2001180	negative regulation of interleukin-10 secretion
0.69	GO:0031642	negative regulation of myelination
0.69	GO:2000666	negative regulation of interleukin-13 secretion
0.68	GO:0097252	oligodendrocyte apoptotic process
0.67	GO:0001783	B cell apoptotic process
0.66	GO:0048713	regulation of oligodendrocyte differentiation
0.66	GO:0030889	negative regulation of B cell proliferation
0.64	GO:0051402	neuron apoptotic process
0.64	GO:0042130	negative regulation of T cell proliferation

0.51

GO:0005031

tumor necrosis factor-activated receptor activity

0.60	GO:0030424	axon
0.53	GO:0031226	intrinsic component of plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O75521|ECI2_HUMAN
Enoyl-CoA delta isomerase 2, mitochondrial
Search

ECI2

0.84	Enoyl-CoA delta isomerase 2, mitochondrial

0.38

GO:0006635

fatty acid beta-oxidation

0.81	GO:0000062	fatty-acyl-CoA binding
0.51	GO:0016853	isomerase activity
0.49	GO:0005102	receptor binding

0.52	GO:0042579	microbody
0.48	GO:0005654	nucleoplasm
0.45	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.51

EC:5

GO:0016853

sp|O75525|KHDR3_HUMAN
KH domain-containing, RNA-binding, signal transduction-associated protein 3
Search

KHDRBS3

0.93	KH domain-containing RNA-binding signal transduction-associated protein 3-1

0.58	GO:0048024	regulation of mRNA splicing, via spliceosome
0.50	GO:0051259	protein oligomerization
0.37	GO:0006397	mRNA processing
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:0033120	positive regulation of RNA splicing
0.35	GO:2001141	regulation of RNA biosynthetic process
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0007283	spermatogenesis

0.58	GO:0003723	RNA binding
0.55	GO:0019904	protein domain specific binding
0.54	GO:0042802	identical protein binding
0.42	GO:0046982	protein heterodimerization activity

0.49	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O75526|RMXL2_HUMAN
RNA-binding motif protein, X-linked-like-2
Search

0.84	RNA binding motif protein, X-linked

0.53	GO:0006509	membrane protein ectodomain proteolysis
0.52	GO:0071347	cellular response to interleukin-1
0.52	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
0.48	GO:0006366	transcription by RNA polymerase II
0.48	GO:0045944	positive regulation of transcription by RNA polymerase II
0.47	GO:0048025	negative regulation of mRNA splicing, via spliceosome
0.47	GO:0051259	protein oligomerization
0.47	GO:0048026	positive regulation of mRNA splicing, via spliceosome
0.44	GO:0008380	RNA splicing
0.43	GO:0006397	mRNA processing

0.59	GO:0003723	RNA binding
0.51	GO:0001047	core promoter binding
0.49	GO:0003682	chromatin binding
0.44	GO:0019904	protein domain specific binding
0.43	GO:0042802	identical protein binding

0.55	GO:0044530	supraspliceosomal complex
0.52	GO:0005719	nuclear euchromatin
0.50	GO:0071013	catalytic step 2 spliceosome
0.50	GO:0070062	extracellular exosome
0.36	GO:0019013	viral nucleocapsid
0.35	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O75528|TADA3_HUMAN
Transcriptional adapter 3
Search

TADA3

0.84	Transcriptional adapter 3-A

0.81	GO:0090043	regulation of tubulin deacetylation
0.78	GO:0031063	regulation of histone deacetylation
0.78	GO:0043966	histone H3 acetylation
0.71	GO:0031647	regulation of protein stability
0.68	GO:0043967	histone H4 acetylation
0.67	GO:0000278	mitotic cell cycle
0.65	GO:0001932	regulation of protein phosphorylation
0.65	GO:0045893	positive regulation of transcription, DNA-templated
0.58	GO:0006357	regulation of transcription by RNA polymerase II
0.52	GO:0006351	transcription, DNA-templated

0.78	GO:0016922	ligand-dependent nuclear receptor binding
0.76	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
0.74	GO:0004402	histone acetyltransferase activity
0.68	GO:0019904	protein domain specific binding
0.43	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.39	GO:0003700	DNA binding transcription factor activity

0.80	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
0.79	GO:0030914	STAGA complex
0.77	GO:0033276	transcription factor TFTC complex
0.72	GO:0072686	mitotic spindle
0.65	GO:0000124	SAGA complex

0.74

GO:0004402

sp|O75529|TAF5L_HUMAN
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Search

TAF5L

0.91	TAF5-like RNA polymerase II/CBP-associated factor-associated protein (Fragment)

0.43	GO:0043966	histone H3 acetylation
0.37	GO:2001141	regulation of RNA biosynthetic process
0.35	GO:0006366	transcription by RNA polymerase II
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression
0.33	GO:0055085	transmembrane transport

0.42	GO:0004402	histone acetyltransferase activity
0.42	GO:0003713	transcription coactivator activity
0.34	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.34	GO:0005515	protein binding
0.34	GO:0003700	DNA binding transcription factor activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.85	GO:0030914	STAGA complex
0.85	GO:0033276	transcription factor TFTC complex
0.42	GO:0016607	nuclear speck
0.41	GO:0036464	cytoplasmic ribonucleoprotein granule
0.30	GO:0016020	membrane

0.42

GO:0004402

sp|O75530|EED_HUMAN
Polycomb protein EED
Search

EED

0.92	Embryonic ectoderm development

0.79	GO:0016571	histone methylation
0.71	GO:2000011	regulation of adaxial/abaxial pattern formation
0.70	GO:0061087	positive regulation of histone H3-K27 methylation
0.68	GO:0006349	regulation of gene expression by genetic imprinting
0.66	GO:1990823	response to leukemia inhibitory factor
0.62	GO:0018022	peptidyl-lysine methylation
0.61	GO:0071345	cellular response to cytokine stimulus
0.61	GO:0000122	negative regulation of transcription by RNA polymerase II
0.38	GO:0021510	spinal cord development
0.35	GO:0016573	histone acetylation

0.71	GO:0046976	histone methyltransferase activity (H3-K27 specific)
0.63	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.61	GO:0003682	chromatin binding
0.59	GO:0042802	identical protein binding
0.35	GO:0004402	histone acetyltransferase activity

0.85	GO:0035098	ESC/E(Z) complex
0.70	GO:0001739	sex chromatin
0.68	GO:0045120	pronucleus
0.55	GO:0005829	cytosol

0.35

GO:0004402

sp|O75531|BAF_HUMAN
Barrier-to-autointegration factor
Search

BANF1

0.94	Barrier-to-autointegration factor B

0.52	GO:0045071	negative regulation of viral genome replication
0.36	GO:0075713	establishment of integrated proviral latency
0.35	GO:0015074	DNA integration
0.35	GO:0007077	mitotic nuclear envelope disassembly
0.35	GO:0010951	negative regulation of endopeptidase activity
0.35	GO:0007084	mitotic nuclear envelope reassembly
0.34	GO:0051169	nuclear transport
0.34	GO:0009615	response to virus

0.56	GO:0097726	LEM domain binding
0.55	GO:0003677	DNA binding
0.51	GO:0047485	protein N-terminus binding
0.50	GO:0008022	protein C-terminus binding
0.47	GO:0042803	protein homodimerization activity
0.46	GO:0019899	enzyme binding
0.36	GO:0004869	cysteine-type endopeptidase inhibitor activity

0.45	GO:0005654	nucleoplasm
0.45	GO:0005829	cytosol
0.39	GO:0005635	nuclear envelope
0.38	GO:0005694	chromosome
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

sp|O75533|SF3B1_HUMAN
Splicing factor 3B subunit 1
Search

SF3B1

0.87	LOW QUALITY PROTEIN: splicing factor 3B subunit 1

0.70	GO:0000398	mRNA splicing, via spliceosome
0.62	GO:0060218	hematopoietic stem cell differentiation
0.61	GO:0060216	definitive hemopoiesis
0.61	GO:0030318	melanocyte differentiation
0.60	GO:0061515	myeloid cell development
0.60	GO:0014032	neural crest cell development
0.57	GO:0022618	ribonucleoprotein complex assembly
0.54	GO:0042981	regulation of apoptotic process
0.44	GO:0001825	blastocyst formation
0.42	GO:0009952	anterior/posterior pattern specification

0.59	GO:0003729	mRNA binding
0.41	GO:0003682	chromatin binding
0.38	GO:0005515	protein binding

0.83	GO:0034693	U11/U12 snRNP
0.79	GO:0005689	U12-type spliceosomal complex
0.77	GO:0005686	U2 snRNP
0.75	GO:0071013	catalytic step 2 spliceosome
0.71	GO:0016607	nuclear speck
0.63	GO:0071004	U2-type prespliceosome
0.43	GO:0016363	nuclear matrix
0.40	GO:0000785	chromatin

sp|O75534|CSDE1_HUMAN
Cold shock domain-containing protein E1
Search

CSDE1

0.89	Cold shock domain-containing protein E1

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.42	GO:0006401	RNA catabolic process
0.41	GO:0016071	mRNA metabolic process
0.41	GO:0010605	negative regulation of macromolecule metabolic process
0.33	GO:0008584	male gonad development

0.55	GO:0003677	DNA binding
0.33	GO:0003723	RNA binding
0.32	GO:0005515	protein binding

0.48	GO:0070937	CRD-mediated mRNA stability complex
0.42	GO:0005794	Golgi apparatus
0.42	GO:0005829	cytosol
0.39	GO:0031966	mitochondrial membrane
0.39	GO:0019866	organelle inner membrane
0.38	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O75541|ZN821_HUMAN
Zinc finger protein 821
Search

ZNF821

0.66	Zinc finger protein 821

0.47	GO:0045944	positive regulation of transcription by RNA polymerase II
0.35	GO:0006351	transcription, DNA-templated

0.51	GO:0003676	nucleic acid binding
0.42	GO:0003700	DNA binding transcription factor activity
0.34	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.36	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|O75553|DAB1_HUMAN
Disabled homolog 1
Search

DAB1

0.96	Disabled like protein 1

0.86	GO:0021813	cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
0.85	GO:0021589	cerebellum structural organization
0.85	GO:0097477	lateral motor column neuron migration
0.85	GO:0021942	radial glia guided migration of Purkinje cell
0.84	GO:0048712	negative regulation of astrocyte differentiation
0.83	GO:0051645	Golgi localization
0.81	GO:0007628	adult walking behavior
0.81	GO:0050771	negative regulation of axonogenesis
0.81	GO:0021517	ventral spinal cord development
0.80	GO:0046426	negative regulation of JAK-STAT cascade

0.47	GO:0043548	phosphatidylinositol 3-kinase binding
0.42	GO:0042169	SH2 domain binding
0.40	GO:0005543	phospholipid binding

0.74	GO:0048471	perinuclear region of cytoplasm
0.53	GO:0043231	intracellular membrane-bounded organelle
0.50	GO:0005579	membrane attack complex
0.46	GO:0005903	brush border
0.46	GO:0014069	postsynaptic density
0.45	GO:0043025	neuronal cell body
0.45	GO:0045177	apical part of cell
0.44	GO:0043005	neuron projection
0.42	GO:0005829	cytosol

sp|O75554|WBP4_HUMAN
WW domain-binding protein 4
Search

WBP4

0.94	WW domain-binding protein 4

0.59	GO:0045292	mRNA cis splicing, via spliceosome
0.38	GO:0006415	translational termination
0.33	GO:0007165	signal transduction

0.63	GO:0008270	zinc ion binding
0.62	GO:0070064	proline-rich region binding
0.51	GO:0003676	nucleic acid binding

0.61	GO:0005634	nucleus
0.50	GO:0031974	membrane-enclosed lumen
0.47	GO:0030529	intracellular ribonucleoprotein complex
0.45	GO:0044446	intracellular organelle part

sp|O75556|SG2A1_HUMAN
Mammaglobin-B
Search

0.97	Mammaglobin-B

0.82

GO:0030521

androgen receptor signaling pathway

0.70	GO:0046982	protein heterodimerization activity
0.36	GO:0016787	hydrolase activity

0.69	GO:0005615	extracellular space
0.30	GO:0031224	intrinsic component of membrane

0.36

GO:0016787

sp|O75558|STX11_HUMAN
Syntaxin-11
Search

STX11

0.97	Syntaxin-11 isoform B

0.69	GO:0016192	vesicle-mediated transport
0.63	GO:0006886	intracellular protein transport
0.63	GO:0061025	membrane fusion
0.61	GO:0007340	acrosome reaction
0.53	GO:0030154	cell differentiation
0.50	GO:0097480	establishment of synaptic vesicle localization
0.50	GO:0099504	synaptic vesicle cycle
0.50	GO:0099643	signal release from synapse
0.50	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.49	GO:0140056	organelle localization by membrane tethering

0.73	GO:0005484	SNAP receptor activity
0.49	GO:0000149	SNARE binding
0.39	GO:0046983	protein dimerization activity
0.35	GO:0048306	calcium-dependent protein binding
0.32	GO:0019901	protein kinase binding
0.32	GO:0005102	receptor binding

0.63	GO:0005794	Golgi apparatus
0.50	GO:0031201	SNARE complex
0.49	GO:0008021	synaptic vesicle
0.42	GO:0030027	lamellipodium
0.42	GO:0016323	basolateral plasma membrane
0.40	GO:0005615	extracellular space
0.37	GO:0045335	phagocytic vesicle
0.34	GO:1903561	extracellular vesicle
0.34	GO:0045121	membrane raft
0.33	GO:0005911	cell-cell junction

sp|O75563|SKAP2_HUMAN
Src kinase-associated phosphoprotein 2
Search

SKAP2

0.97	Src kinase-associated phosphoprotein 2

0.57	GO:0008285	negative regulation of cell proliferation
0.53	GO:0002757	immune response-activating signal transduction
0.50	GO:0016310	phosphorylation
0.49	GO:0009967	positive regulation of signal transduction
0.45	GO:0042113	B cell activation
0.44	GO:0002768	immune response-regulating cell surface receptor signaling pathway
0.43	GO:0072659	protein localization to plasma membrane
0.42	GO:0045785	positive regulation of cell adhesion
0.42	GO:0045944	positive regulation of transcription by RNA polymerase II
0.37	GO:0002250	adaptive immune response

0.53	GO:0005070	SH3/SH2 adaptor activity
0.52	GO:0016301	kinase activity
0.45	GO:0042169	SH2 domain binding
0.44	GO:0019903	protein phosphatase binding
0.42	GO:0019901	protein kinase binding
0.35	GO:0032403	protein complex binding
0.34	GO:0017124	SH3 domain binding

0.53	GO:0005829	cytosol
0.52	GO:0005654	nucleoplasm
0.46	GO:0005886	plasma membrane
0.42	GO:0043235	receptor complex
0.42	GO:0005911	cell-cell junction
0.30	GO:0016021	integral component of membrane

sp|O75564|JERKY_HUMAN
Jerky protein homolog
Search

JRK

0.96	Jerky protein homolog

0.37	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.33	GO:0007417	central nervous system development
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression
0.33	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.54	GO:0003677	DNA binding
0.51	GO:0003729	mRNA binding
0.35	GO:0005515	protein binding
0.33	GO:0004519	endonuclease activity
0.31	GO:0008270	zinc ion binding

0.45	GO:0005634	nucleus
0.44	GO:0030529	intracellular ribonucleoprotein complex
0.39	GO:0005737	cytoplasm
0.35	GO:0043232	intracellular non-membrane-bounded organelle

sp|O75569|PRKRA_HUMAN
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Search

PRKRA

0.93	Interferon-inducible double-stranded RNA-dependent protein kinase activator A

0.85	GO:0030422	production of siRNA involved in RNA interference
0.73	GO:0043085	positive regulation of catalytic activity
0.56	GO:0042473	outer ear morphogenesis
0.55	GO:0016310	phosphorylation
0.55	GO:0042474	middle ear morphogenesis
0.55	GO:0031054	pre-miRNA processing
0.54	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
0.52	GO:0048705	skeletal system morphogenesis
0.51	GO:0050821	protein stabilization
0.49	GO:0034599	cellular response to oxidative stress

0.77	GO:0003725	double-stranded RNA binding
0.75	GO:0008047	enzyme activator activity
0.56	GO:0016301	kinase activity
0.53	GO:0070883	pre-miRNA binding
0.49	GO:0042803	protein homodimerization activity
0.48	GO:0019899	enzyme binding

0.56	GO:0070578	RISC-loading complex
0.48	GO:0048471	perinuclear region of cytoplasm
0.46	GO:0005654	nucleoplasm
0.45	GO:0005829	cytosol
0.35	GO:0005730	nucleolus
0.30	GO:0016020	membrane

sp|O75570|RF1M_HUMAN
Peptide chain release factor 1, mitochondrial
Search

MTRF1

0.41	Mitochondrial translational release factor 1

0.74	GO:0006415	translational termination
0.35	GO:0006449	regulation of translational termination
0.34	GO:0032543	mitochondrial translation

0.75	GO:0003747	translation release factor activity
0.35	GO:0008270	zinc ion binding

0.45	GO:0005739	mitochondrion
0.35	GO:0005634	nucleus
0.33	GO:0019866	organelle inner membrane

sp|O75575|RPC9_HUMAN
DNA-directed RNA polymerase III subunit RPC9
Search

CRCP

0.94	CGRP receptor component

0.71	GO:0006383	transcription by RNA polymerase III
0.65	GO:0007218	neuropeptide signaling pathway
0.48	GO:0006352	DNA-templated transcription, initiation
0.40	GO:0061484	hematopoietic stem cell homeostasis

0.75	GO:0001635	calcitonin gene-related peptide receptor activity
0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.53	GO:1901265	nucleoside phosphate binding
0.51	GO:0036094	small molecule binding

0.68	GO:0001669	acrosomal vesicle
0.64	GO:0061695	transferase complex, transferring phosphorus-containing groups
0.49	GO:0044451	nucleoplasm part
0.30	GO:0031224	intrinsic component of membrane

0.70

EC:2.7.7.6

GO:0003899

sp|O75578|ITA10_HUMAN
Integrin alpha-10
Search

ITGA10

0.94	Integrin subunit alpha 10

0.80	GO:0007229	integrin-mediated signaling pathway
0.72	GO:0007155	cell adhesion
0.48	GO:0006929	substrate-dependent cell migration
0.47	GO:0038065	collagen-activated signaling pathway
0.38	GO:0016559	peroxisome fission
0.36	GO:0030198	extracellular matrix organization
0.35	GO:0001649	osteoblast differentiation
0.33	GO:0007517	muscle organ development

0.66	GO:0098639	collagen binding involved in cell-matrix adhesion
0.48	GO:0038064	collagen receptor activity
0.34	GO:0046872	metal ion binding

0.81	GO:0008305	integrin complex
0.46	GO:0005925	focal adhesion
0.38	GO:0005779	integral component of peroxisomal membrane

sp|O75581|LRP6_HUMAN
Low-density lipoprotein receptor-related protein 6
Search

0.45	Low-density lipoprotein receptor-related protein 6

0.75	GO:0060070	canonical Wnt signaling pathway
0.61	GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification
0.60	GO:2000055	positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
0.59	GO:0034392	negative regulation of smooth muscle cell apoptotic process
0.59	GO:0071397	cellular response to cholesterol
0.58	GO:0014029	neural crest formation
0.56	GO:0060828	regulation of canonical Wnt signaling pathway
0.56	GO:0051091	positive regulation of DNA binding transcription factor activity
0.56	GO:0071901	negative regulation of protein serine/threonine kinase activity
0.55	GO:0014033	neural crest cell differentiation

0.77	GO:0017147	Wnt-protein binding
0.76	GO:0042813	Wnt-activated receptor activity
0.74	GO:0071936	coreceptor activity involved in Wnt signaling pathway
0.58	GO:0005041	low-density lipoprotein receptor activity
0.57	GO:0005109	frizzled binding
0.55	GO:0019534	toxin transmembrane transporter activity
0.55	GO:0019210	kinase inhibitor activity
0.51	GO:0042803	protein homodimerization activity
0.46	GO:0034185	apolipoprotein binding

0.59	GO:1990851	Wnt-Frizzled-LRP5/6 complex
0.59	GO:1990909	Wnt signalosome
0.55	GO:0005901	caveola
0.53	GO:0005769	early endosome
0.51	GO:0009986	cell surface
0.49	GO:0005794	Golgi apparatus
0.47	GO:0043235	receptor complex
0.45	GO:0043025	neuronal cell body
0.43	GO:0045202	synapse
0.36	GO:0005739	mitochondrion

sp|O75582|KS6A5_HUMAN
Ribosomal protein S6 kinase alpha-5
Search

RPS6KA5

0.75	Ribosomal protein S6 kinase, polypeptide 5

0.62	GO:0006468	protein phosphorylation
0.61	GO:0035556	intracellular signal transduction
0.57	GO:0033129	positive regulation of histone phosphorylation
0.55	GO:0070498	interleukin-1-mediated signaling pathway
0.55	GO:0035066	positive regulation of histone acetylation
0.53	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.52	GO:0018209	peptidyl-serine modification
0.50	GO:0045944	positive regulation of transcription by RNA polymerase II
0.49	GO:0016570	histone modification
0.48	GO:0045892	negative regulation of transcription, DNA-templated

0.69	GO:0004674	protein serine/threonine kinase activity
0.63	GO:0000287	magnesium ion binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding
0.32	GO:0003676	nucleic acid binding

0.47	GO:0005654	nucleoplasm
0.39	GO:0005737	cytoplasm
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016020	membrane

0.69

GO:0004674

sp|O75586|MED6_HUMAN
Mediator of RNA polymerase II transcription subunit 6
Search

MED6

0.83	Mediator of RNA polymerase II transcription subunit 6

0.70	GO:0006357	regulation of transcription by RNA polymerase II
0.53	GO:0006351	transcription, DNA-templated
0.51	GO:0019827	stem cell population maintenance
0.44	GO:0065004	protein-DNA complex assembly
0.36	GO:0045893	positive regulation of transcription, DNA-templated
0.36	GO:0016567	protein ubiquitination

0.78	GO:0001104	RNA polymerase II transcription cofactor activity
0.47	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.45	GO:0003713	transcription coactivator activity
0.40	GO:0003677	DNA binding
0.37	GO:0061630	ubiquitin protein ligase activity
0.36	GO:0008134	transcription factor binding

0.76	GO:0016592	mediator complex
0.47	GO:0070847	core mediator complex
0.37	GO:0000151	ubiquitin ligase complex
0.30	GO:0016020	membrane

sp|O75592|MYCB2_HUMAN
E3 ubiquitin-protein ligase MYCBP2
Search

MYCBP2

0.81	MYC binding protein 2

0.63	GO:0042068	regulation of pteridine metabolic process
0.60	GO:0021986	habenula development
0.59	GO:0016198	axon choice point recognition
0.58	GO:0031290	retinal ganglion cell axon guidance
0.57	GO:0048066	developmental pigmentation
0.51	GO:0016567	protein ubiquitination

0.51

GO:0004842

ubiquitin-protein transferase activity

0.57	GO:0005634	nucleus
0.39	GO:0005737	cytoplasm

0.51

GO:0004842

sp|O75593|FOXH1_HUMAN
Forkhead box protein H1
Search

FOXH1

0.97	Forkhead activin signal transducer 1

0.79	GO:2000824	negative regulation of androgen receptor activity
0.78	GO:0035054	embryonic heart tube anterior/posterior pattern specification
0.76	GO:0003139	secondary heart field specification
0.76	GO:0048318	axial mesoderm development
0.76	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
0.75	GO:0003222	ventricular trabecula myocardium morphogenesis
0.75	GO:0003215	cardiac right ventricle morphogenesis
0.74	GO:0035909	aorta morphogenesis
0.72	GO:0003151	outflow tract morphogenesis
0.72	GO:0001947	heart looping

0.76	GO:0070410	co-SMAD binding
0.75	GO:0070412	R-SMAD binding
0.75	GO:0050681	androgen receptor binding
0.74	GO:0043425	bHLH transcription factor binding
0.74	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
0.72	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.67	GO:0001104	RNA polymerase II transcription cofactor activity
0.65	GO:0019904	protein domain specific binding
0.65	GO:0044212	transcription regulatory region DNA binding
0.65	GO:0043565	sequence-specific DNA binding

0.78	GO:0032444	activin responsive factor complex
0.64	GO:0000790	nuclear chromatin
0.37	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

sp|O75594|PGRP1_HUMAN
Peptidoglycan recognition protein 1
Search

PGLYRP1

0.61	Peptidoglycan recognition protein 1

0.74	GO:0009253	peptidoglycan catabolic process
0.71	GO:0045087	innate immune response
0.59	GO:0051714	positive regulation of cytolysis in other organism
0.56	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
0.56	GO:0016045	detection of bacterium
0.55	GO:0050830	defense response to Gram-positive bacterium
0.53	GO:0002221	pattern recognition receptor signaling pathway
0.52	GO:0031640	killing of cells of other organism
0.47	GO:0032824	negative regulation of natural killer cell differentiation
0.46	GO:0032826	regulation of natural killer cell differentiation involved in immune response

0.76	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity
0.70	GO:0042834	peptidoglycan binding
0.63	GO:0008270	zinc ion binding
0.59	GO:0016019	peptidoglycan receptor activity
0.34	GO:0005125	cytokine activity
0.34	GO:0005044	scavenger receptor activity

0.39	GO:0005576	extracellular region
0.37	GO:0097013	phagocytic vesicle lumen
0.37	GO:1904724	tertiary granule lumen
0.37	GO:0035580	specific granule lumen
0.33	GO:0031314	extrinsic component of mitochondrial inner membrane
0.30	GO:0016021	integral component of membrane

0.76

EC:3.5.1.28

GO:0008745

sp|O75596|CLC3A_HUMAN
C-type lectin domain family 3 member A
Search

CLEC3A

0.97	C-type (Calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 1 (Cartilage-derived) (Predicted)

0.41	GO:0030282	bone mineralization
0.40	GO:0071560	cellular response to transforming growth factor beta stimulus
0.37	GO:0010756	positive regulation of plasminogen activation
0.36	GO:0001501	skeletal system development
0.34	GO:0055114	oxidation-reduction process

0.68	GO:0030246	carbohydrate binding
0.43	GO:0036143	kringle domain binding
0.40	GO:0008201	heparin binding
0.38	GO:0005509	calcium ion binding
0.36	GO:0008270	zinc ion binding
0.34	GO:0016491	oxidoreductase activity

0.42	GO:0001652	granular component
0.41	GO:0005576	extracellular region
0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.34

GO:0016491

sp|O75600|KBL_HUMAN
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
Search

GCAT

0.48	Glycine C-acetyltransferase

0.79	GO:0006567	threonine catabolic process
0.49	GO:0009058	biosynthetic process
0.36	GO:0006544	glycine metabolic process
0.36	GO:0042737	drug catabolic process
0.36	GO:0006334	nucleosome assembly
0.35	GO:0007313	maternal specification of dorsal/ventral axis, oocyte, soma encoded
0.35	GO:0007362	terminal region determination
0.35	GO:0008293	torso signaling pathway
0.34	GO:0008586	imaginal disc-derived wing vein morphogenesis
0.33	GO:0016485	protein processing

0.83	GO:0008890	glycine C-acetyltransferase activity
0.67	GO:0030170	pyridoxal phosphate binding
0.48	GO:0016874	ligase activity
0.33	GO:0003677	DNA binding
0.33	GO:0005509	calcium ion binding

0.51	GO:0016607	nuclear speck
0.44	GO:0005739	mitochondrion
0.43	GO:0019866	organelle inner membrane
0.35	GO:0000786	nucleosome
0.30	GO:0031224	intrinsic component of membrane

0.83	EC:2.3.1.29	GO:0008890
0.83	KEGG:R00371	GO:0008890

sp|O75602|SPAG6_HUMAN
Sperm-associated antigen 6
Search

SPAG6

0.94	Sperm-associated antigen 6

0.51	GO:0007288	sperm axoneme assembly
0.50	GO:0021591	ventricular system development

0.36

GO:0005515

protein binding

0.68	GO:0015630	microtubule cytoskeleton
0.52	GO:1990716	axonemal central apparatus
0.50	GO:0097228	sperm principal piece
0.41	GO:0099513	polymeric cytoskeletal fiber
0.38	GO:0005634	nucleus

sp|O75603|GCM2_HUMAN
Chorion-specific transcription factor GCMb
Search

GCM2

0.95	Transcription factor Glial cells missing-2

0.80	GO:0060017	parathyroid gland development
0.74	GO:0055074	calcium ion homeostasis
0.70	GO:0072503	cellular divalent inorganic cation homeostasis
0.70	GO:0072502	cellular trivalent inorganic anion homeostasis
0.70	GO:0072501	cellular divalent inorganic anion homeostasis
0.70	GO:0030320	cellular monovalent inorganic anion homeostasis
0.70	GO:0055062	phosphate ion homeostasis
0.68	GO:0006366	transcription by RNA polymerase II
0.66	GO:0006875	cellular metal ion homeostasis
0.64	GO:0006357	regulation of transcription by RNA polymerase II

0.66	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.60	GO:0043565	sequence-specific DNA binding
0.45	GO:0042826	histone deacetylase binding
0.43	GO:0001012	RNA polymerase II regulatory region DNA binding
0.41	GO:0008134	transcription factor binding
0.41	GO:0003690	double-stranded DNA binding
0.39	GO:0008270	zinc ion binding

0.61	GO:0005634	nucleus
0.42	GO:0005667	transcription factor complex

sp|O75604|UBP2_HUMAN
Ubiquitin carboxyl-terminal hydrolase 2
Search

USP2

0.84	Ubiquitin carboxyl-terminal hydrolase 2

0.76	GO:0016579	protein deubiquitination
0.72	GO:0006511	ubiquitin-dependent protein catabolic process
0.59	GO:0043153	entrainment of circadian clock by photoperiod
0.58	GO:0045475	locomotor rhythm
0.57	GO:0032922	circadian regulation of gene expression
0.55	GO:0045931	positive regulation of mitotic cell cycle
0.54	GO:0050821	protein stabilization
0.53	GO:0000122	negative regulation of transcription by RNA polymerase II
0.40	GO:0007517	muscle organ development
0.38	GO:0051926	negative regulation of calcium ion transport

0.76	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.56	GO:0030332	cyclin binding
0.54	GO:0031625	ubiquitin protein ligase binding
0.51	GO:0042802	identical protein binding
0.35	GO:0046872	metal ion binding
0.35	GO:0004197	cysteine-type endopeptidase activity

0.54	GO:0048471	perinuclear region of cytoplasm
0.52	GO:0005938	cell cortex
0.45	GO:0005634	nucleus
0.38	GO:0005813	centrosome
0.34	GO:0031974	membrane-enclosed lumen
0.30	GO:0031224	intrinsic component of membrane

0.76

GO:0036459

sp|O75607|NPM3_HUMAN
Nucleoplasmin-3
Search

NPM3

0.95	Nucleophosmin/nucleoplasmin 3

0.80	GO:0009303	rRNA transcription
0.64	GO:0006364	rRNA processing
0.44	GO:0008543	fibroblast growth factor receptor signaling pathway
0.44	GO:0010469	regulation of receptor activity
0.35	GO:0007275	multicellular organism development

0.45	GO:0008083	growth factor activity
0.45	GO:0005104	fibroblast growth factor receptor binding
0.38	GO:0003676	nucleic acid binding
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0032561	guanyl ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.68	GO:0015629	actin cytoskeleton
0.68	GO:0005730	nucleolus
0.64	GO:0005829	cytosol
0.40	GO:0005576	extracellular region

sp|O75608|LYPA1_HUMAN
Acyl-protein thioesterase 1
Search

LYPLA1

0.85	Lysophospholipase II

0.59	GO:0042997	negative regulation of Golgi to plasma membrane protein transport
0.59	GO:0098734	macromolecule depalmitoylation
0.58	GO:0042159	lipoprotein catabolic process
0.54	GO:0035601	protein deacylation

0.59	GO:0008474	palmitoyl-(protein) hydrolase activity
0.51	GO:0016298	lipase activity
0.44	GO:0052689	carboxylic ester hydrolase activity

0.48	GO:0005829	cytosol
0.44	GO:0005739	mitochondrion

0.59	EC:3.1.2.22	GO:0008474
0.44	KEGG:R00630	GO:0052689

sp|O75610|LFTY1_HUMAN
Left-right determination factor 1
Search

0.97	Left-right determination factor 1

0.81	GO:0016049	cell growth
0.75	GO:0010469	regulation of receptor activity
0.55	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.55	GO:0060395	SMAD protein signal transduction
0.54	GO:0030509	BMP signaling pathway
0.51	GO:0043408	regulation of MAPK cascade
0.50	GO:0048468	cell development
0.50	GO:0042981	regulation of apoptotic process
0.44	GO:1900123	regulation of nodal receptor complex assembly
0.43	GO:0007368	determination of left/right symmetry

0.85	GO:0005160	transforming growth factor beta receptor binding
0.78	GO:0008083	growth factor activity
0.52	GO:0005125	cytokine activity
0.43	GO:0038100	nodal binding

0.66	GO:0005576	extracellular region
0.38	GO:0031093	platelet alpha granule lumen

sp|O75616|ERAL1_HUMAN
GTPase Era, mitochondrial
Search

ERAL1

0.92	Era like 12S mitochondrial rRNA chaperone 1

0.76

GO:0000028

ribosomal small subunit assembly

0.79	GO:0043024	ribosomal small subunit binding
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.61	GO:0019843	rRNA binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0032555	purine ribonucleotide binding

0.69	GO:0005759	mitochondrial matrix
0.63	GO:0005829	cytosol

sp|O75618|DEDD_HUMAN
Death effector domain-containing protein
Search

DEDD

0.97	Death effector domain containing

0.72	GO:0042981	regulation of apoptotic process
0.59	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
0.59	GO:1901837	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
0.57	GO:0046697	decidualization
0.55	GO:0042177	negative regulation of protein catabolic process
0.41	GO:0007283	spermatogenesis
0.35	GO:0006351	transcription, DNA-templated

0.44	GO:0003677	DNA binding
0.35	GO:0005515	protein binding
0.34	GO:0005509	calcium ion binding

0.52	GO:0005730	nucleolus
0.39	GO:0005737	cytoplasm

sp|O75626|PRDM1_HUMAN
PR domain zinc finger protein 1
Search

PRDM1

0.96	PR domain containing 1 with ZNF domain

0.62	GO:1990654	sebum secreting cell proliferation
0.62	GO:0033082	regulation of extrathymic T cell differentiation
0.60	GO:0051136	regulation of NK T cell differentiation
0.60	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
0.60	GO:0060576	intestinal epithelial cell development
0.60	GO:0032823	regulation of natural killer cell differentiation
0.59	GO:0045579	positive regulation of B cell differentiation
0.59	GO:0030889	negative regulation of B cell proliferation
0.58	GO:0060976	coronary vasculature development
0.58	GO:0003170	heart valve development

0.58	GO:1990841	promoter-specific chromatin binding
0.58	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.57	GO:0042826	histone deacetylase binding
0.56	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0008168	methyltransferase activity
0.33	GO:0046872	metal ion binding

0.45	GO:0005634	nucleus
0.40	GO:0005737	cytoplasm
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part

0.35

GO:0008168

sp|O75628|REM1_HUMAN
GTP-binding protein REM 1
Search

REM1

0.81	GTP-binding protein GEM

0.85	GO:1901842	negative regulation of high voltage-gated calcium channel activity
0.61	GO:0007165	signal transduction
0.42	GO:0051310	metaphase plate congression
0.40	GO:0000278	mitotic cell cycle
0.38	GO:0051276	chromosome organization
0.35	GO:0006955	immune response

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0000287	magnesium ion binding
0.37	GO:0005246	calcium channel regulator activity
0.35	GO:0005516	calmodulin binding

0.42	GO:0051233	spindle midzone
0.42	GO:0030496	midbody
0.41	GO:0072686	mitotic spindle
0.40	GO:0009898	cytoplasmic side of plasma membrane
0.37	GO:0005634	nucleus

sp|O75629|CREG1_HUMAN
Protein CREG1
Search

CREG1

0.97	Cellular repressor of E1A-stimulated genes 1

0.44	GO:0006355	regulation of transcription, DNA-templated
0.38	GO:0040008	regulation of growth
0.37	GO:0043312	neutrophil degranulation
0.36	GO:0008283	cell proliferation
0.35	GO:1903507	negative regulation of nucleic acid-templated transcription
0.35	GO:0007275	multicellular organism development
0.32	GO:0055114	oxidation-reduction process

0.56	GO:0048037	cofactor binding
0.52	GO:0008134	transcription factor binding
0.36	GO:0003714	transcription corepressor activity
0.33	GO:0016730	oxidoreductase activity, acting on iron-sulfur proteins as donors

0.53	GO:0005667	transcription factor complex
0.52	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.37	GO:0035578	azurophil granule lumen
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:1.18

GO:0016730

sp|O75631|UPK3A_HUMAN
Uroplakin-3a
Search

UPK3A

0.97	Uroplakin-3a isoform B

0.75	GO:0060157	urinary bladder development
0.73	GO:0055078	sodium ion homeostasis
0.70	GO:0055075	potassium ion homeostasis
0.69	GO:0015840	urea transport
0.69	GO:0006833	water transport
0.68	GO:0001822	kidney development
0.66	GO:0030855	epithelial cell differentiation
0.62	GO:0000902	cell morphogenesis
0.35	GO:0046325	negative regulation of glucose import
0.33	GO:0010629	negative regulation of gene expression

0.38	GO:0005515	protein binding
0.32	GO:0008270	zinc ion binding

0.68	GO:0016324	apical plasma membrane
0.41	GO:0070062	extracellular exosome
0.41	GO:0005789	endoplasmic reticulum membrane
0.35	GO:0005887	integral component of plasma membrane

sp|O75635|SPB7_HUMAN
Serpin B7
Search

SERPINB7

0.83	Heterochromatin-associated protein MENT

0.58	GO:0010951	negative regulation of endopeptidase activity
0.48	GO:0043066	negative regulation of apoptotic process
0.44	GO:0061108	seminal vesicle epithelium development
0.44	GO:0042628	mating plug formation
0.44	GO:0010757	negative regulation of plasminogen activation
0.43	GO:0051094	positive regulation of developmental process
0.43	GO:0051240	positive regulation of multicellular organismal process
0.43	GO:0090331	negative regulation of platelet aggregation
0.43	GO:0021683	cerebellar granular layer morphogenesis
0.43	GO:0010766	negative regulation of sodium ion transport

0.60	GO:0004867	serine-type endopeptidase inhibitor activity
0.42	GO:0008201	heparin binding
0.40	GO:0005102	receptor binding
0.36	GO:0002020	protease binding
0.36	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.35	GO:0008233	peptidase activity
0.31	GO:0046872	metal ion binding

0.73	GO:0005615	extracellular space
0.43	GO:0031232	extrinsic component of external side of plasma membrane
0.42	GO:0031091	platelet alpha granule
0.42	GO:0031594	neuromuscular junction
0.40	GO:0031012	extracellular matrix
0.40	GO:0005829	cytosol
0.35	GO:0005654	nucleoplasm
0.34	GO:0005794	Golgi apparatus
0.34	GO:1903561	extracellular vesicle
0.33	GO:0043025	neuronal cell body

0.35

GO:0008233

sp|O75636|FCN3_HUMAN
Ficolin-3
Search

FCN3

0.85

Ficolin A

0.65	GO:0043654	recognition of apoptotic cell
0.64	GO:0046597	negative regulation of viral entry into host cell
0.64	GO:0001867	complement activation, lectin pathway
0.61	GO:0030199	collagen fibril organization
0.57	GO:0051607	defense response to virus
0.55	GO:0048523	negative regulation of cellular process
0.53	GO:0010558	negative regulation of macromolecule biosynthetic process
0.52	GO:0051172	negative regulation of nitrogen compound metabolic process
0.49	GO:0001525	angiogenesis
0.47	GO:0042981	regulation of apoptotic process

0.62	GO:0003823	antigen binding
0.44	GO:0008201	heparin binding
0.42	GO:0005518	collagen binding
0.40	GO:0090729	toxin activity
0.37	GO:0005178	integrin binding
0.37	GO:0030246	carbohydrate binding
0.37	GO:0008233	peptidase activity
0.36	GO:0017171	serine hydrolase activity
0.35	GO:0005509	calcium ion binding
0.35	GO:0048407	platelet-derived growth factor binding

0.59	GO:0044421	extracellular region part
0.46	GO:0005581	collagen trimer
0.35	GO:0099512	supramolecular fiber
0.35	GO:0042383	sarcolemma
0.34	GO:0031982	vesicle
0.32	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

0.37

GO:0008233

sp|O75638|CTAG2_HUMAN
Cancer/testis antigen 2
Search

CTAG2

0.94	Cancer/testis antigen 2

0.41	GO:0051276	chromosome organization
0.40	GO:0007412	axon target recognition
0.40	GO:0000494	box C/D snoRNA 3'-end processing
0.39	GO:1902284	neuron projection extension involved in neuron projection guidance
0.39	GO:0031290	retinal ganglion cell axon guidance
0.39	GO:0071711	basement membrane organization
0.39	GO:0048675	axon extension
0.39	GO:0006356	regulation of transcription by RNA polymerase I
0.38	GO:0032259	methylation
0.38	GO:0006281	DNA repair

0.50	GO:0005515	protein binding
0.50	GO:0042302	structural constituent of cuticle
0.42	GO:0004386	helicase activity
0.42	GO:0005201	extracellular matrix structural constituent
0.41	GO:0008094	DNA-dependent ATPase activity
0.40	GO:1990259	histone-glutamine methyltransferase activity
0.39	GO:0140097	catalytic activity, acting on DNA
0.39	GO:0004527	exonuclease activity
0.38	GO:0003676	nucleic acid binding
0.38	GO:0032559	adenyl ribonucleotide binding

0.54	GO:0005813	centrosome
0.45	GO:0005581	collagen trimer
0.39	GO:0031428	box C/D snoRNP complex
0.38	GO:0005604	basement membrane
0.38	GO:0032040	small-subunit processome
0.38	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.37

GO:0008649

sp|O75643|U520_HUMAN
U5 small nuclear ribonucleoprotein 200 kDa helicase
Search

SNRNP200

0.80	Activating signal cointegrator 1 complex subunit 3

0.50	GO:0000398	mRNA splicing, via spliceosome
0.37	GO:0001649	osteoblast differentiation
0.34	GO:0010501	RNA secondary structure unwinding
0.34	GO:0022618	ribonucleoprotein complex assembly

0.58	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.50	GO:0008186	RNA-dependent ATPase activity
0.49	GO:0042802	identical protein binding
0.44	GO:0140098	catalytic activity, acting on RNA
0.33	GO:0008270	zinc ion binding

0.56	GO:0019013	viral nucleocapsid
0.54	GO:0005682	U5 snRNP
0.53	GO:0071013	catalytic step 2 spliceosome
0.52	GO:0046540	U4/U6 x U5 tri-snRNP complex
0.47	GO:0005654	nucleoplasm
0.34	GO:0005730	nucleolus
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|O75648|MTU1_HUMAN
Mitochondrial tRNA-specific 2-thiouridylase 1
Search

TRMU

0.74	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase

0.66	GO:0008033	tRNA processing
0.50	GO:1900864	mitochondrial RNA modification
0.50	GO:0000963	mitochondrial RNA processing
0.46	GO:0070525	tRNA threonylcarbamoyladenosine metabolic process
0.41	GO:0032259	methylation
0.32	GO:0032981	mitochondrial respiratory chain complex I assembly

0.71	GO:0016783	sulfurtransferase activity
0.41	GO:0008168	methyltransferase activity
0.39	GO:0000049	tRNA binding
0.36	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding

0.50	GO:0005654	nucleoplasm
0.46	GO:0005739	mitochondrion

0.71

EC:2.8.1

GO:0016783

sp|O75663|TIPRL_HUMAN
TIP41-like protein
Search

TIPRL

0.97	TOR signaling pathway regulator

0.75	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.73	GO:0000077	DNA damage checkpoint
0.53	GO:0043009	chordate embryonic development
0.53	GO:0043066	negative regulation of apoptotic process
0.39	GO:0016192	vesicle-mediated transport
0.34	GO:0035335	peptidyl-tyrosine dephosphorylation

0.36	GO:0005515	protein binding
0.34	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.34	GO:0004725	protein tyrosine phosphatase activity

0.37	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.34

GO:0008138

sp|O75665|OFD1_HUMAN
Oral-facial-digital syndrome 1 protein
Search

OFD1

0.94	OFD1, centriole and centriolar satellite protein

0.45	GO:2000314	negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
0.43	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry
0.42	GO:0010172	embryonic body morphogenesis
0.42	GO:0007099	centriole replication
0.42	GO:0090307	mitotic spindle assembly
0.42	GO:0035082	axoneme assembly

0.74	GO:0042802	identical protein binding
0.42	GO:0043014	alpha-tubulin binding
0.41	GO:0043015	gamma-tubulin binding

0.83	GO:0036064	ciliary basal body
0.83	GO:0005814	centriole
0.78	GO:0005813	centrosome
0.30	GO:0016020	membrane

sp|O75674|TM1L1_HUMAN
TOM1-like protein 1
Search

TOM1L1

0.97	Target of myb1 like 1 membrane trafficking protein

0.80	GO:0032147	activation of protein kinase activity
0.76	GO:0031954	positive regulation of protein autophosphorylation
0.71	GO:0045839	negative regulation of mitotic nuclear division
0.69	GO:0006886	intracellular protein transport
0.54	GO:0007165	signal transduction

0.83	GO:0030295	protein kinase activator activity
0.70	GO:0030276	clathrin binding
0.68	GO:0019901	protein kinase binding

0.66	GO:0005768	endosome
0.60	GO:0005829	cytosol

sp|O75676|KS6A4_HUMAN
Ribosomal protein S6 kinase alpha-4
Search

RPS6KA4

0.74	Ribosomal protein S6 kinase, polypeptide 4

0.63	GO:0006468	protein phosphorylation
0.62	GO:0035556	intracellular signal transduction
0.61	GO:0033129	positive regulation of histone phosphorylation
0.58	GO:0070498	interleukin-1-mediated signaling pathway
0.58	GO:0035066	positive regulation of histone acetylation
0.55	GO:0018209	peptidyl-serine modification
0.52	GO:0045944	positive regulation of transcription by RNA polymerase II
0.52	GO:0016570	histone modification
0.48	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.44	GO:0045892	negative regulation of transcription, DNA-templated

0.69	GO:0004674	protein serine/threonine kinase activity
0.63	GO:0000287	magnesium ion binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0005515	protein binding
0.32	GO:0003676	nucleic acid binding

0.50	GO:0005654	nucleoplasm
0.45	GO:0005829	cytosol
0.34	GO:0005840	ribosome

0.69

GO:0004674

sp|O75677|RFPL1_HUMAN
Ret finger protein-like 1
Search

0.97	Ret finger protein like 1

0.40	GO:0032897	negative regulation of viral transcription
0.39	GO:0051091	positive regulation of DNA binding transcription factor activity
0.39	GO:0045087	innate immune response
0.36	GO:0016567	protein ubiquitination
0.35	GO:0001666	response to hypoxia
0.34	GO:0031047	gene silencing by RNA
0.34	GO:0032526	response to retinoic acid
0.34	GO:0070206	protein trimerization
0.34	GO:0090086	negative regulation of protein deubiquitination
0.34	GO:0046598	positive regulation of viral entry into host cell

0.52	GO:0046872	metal ion binding
0.37	GO:0016874	ligase activity
0.36	GO:0004842	ubiquitin-protein transferase activity
0.35	GO:0005515	protein binding
0.32	GO:0003676	nucleic acid binding

0.37	GO:0005622	intracellular
0.36	GO:0043227	membrane-bounded organelle
0.33	GO:0098805	whole membrane
0.32	GO:0044422	organelle part
0.32	GO:1990234	transferase complex
0.32	GO:0019867	outer membrane
0.32	GO:0031974	membrane-enclosed lumen
0.32	GO:0031975	envelope
0.31	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.37	EC:6	GO:0016874
0.36	KEGG:R03876	GO:0004842

sp|O75678|RFPL2_HUMAN
Ret finger protein-like 2
Search

0.97	Ret finger protein like 1

0.45	GO:0032897	negative regulation of viral transcription
0.44	GO:1902187	negative regulation of viral release from host cell
0.44	GO:1900041	negative regulation of interleukin-2 secretion
0.44	GO:0072643	interferon-gamma secretion
0.43	GO:0090281	negative regulation of calcium ion import
0.43	GO:0070206	protein trimerization
0.43	GO:0032720	negative regulation of tumor necrosis factor production
0.43	GO:0070534	protein K63-linked ubiquitination
0.42	GO:0051127	positive regulation of actin nucleation
0.42	GO:0051091	positive regulation of DNA binding transcription factor activity

0.51	GO:0046872	metal ion binding
0.41	GO:0004842	ubiquitin-protein transferase activity
0.41	GO:0042802	identical protein binding
0.36	GO:0016874	ligase activity
0.35	GO:0061659	ubiquitin-like protein ligase activity
0.33	GO:0008134	transcription factor binding
0.33	GO:0035035	histone acetyltransferase binding
0.33	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.33	GO:0003676	nucleic acid binding
0.33	GO:0051427	hormone receptor binding

0.42	GO:0001650	fibrillar center
0.41	GO:0030904	retromer complex
0.41	GO:0031965	nuclear membrane
0.40	GO:0005768	endosome
0.40	GO:0005654	nucleoplasm
0.39	GO:0005829	cytosol
0.35	GO:0019005	SCF ubiquitin ligase complex
0.32	GO:0005794	Golgi apparatus
0.32	GO:0005887	integral component of plasma membrane
0.32	GO:0005882	intermediate filament

0.36	EC:6	GO:0016874
0.41	KEGG:R03876	GO:0004842

sp|O75679|RFPL3_HUMAN
Ret finger protein-like 3
Search

0.97	Ret finger protein like 1

0.40	GO:0032897	negative regulation of viral transcription
0.39	GO:0051091	positive regulation of DNA binding transcription factor activity
0.39	GO:0045087	innate immune response
0.36	GO:0016567	protein ubiquitination
0.35	GO:0001666	response to hypoxia
0.35	GO:0031047	gene silencing by RNA
0.34	GO:0032526	response to retinoic acid
0.34	GO:0070206	protein trimerization
0.34	GO:0090086	negative regulation of protein deubiquitination
0.34	GO:0046598	positive regulation of viral entry into host cell

0.52	GO:0046872	metal ion binding
0.37	GO:0016874	ligase activity
0.36	GO:0004842	ubiquitin-protein transferase activity
0.35	GO:0005515	protein binding
0.32	GO:0020037	heme binding
0.32	GO:0003676	nucleic acid binding

0.37	GO:0005622	intracellular
0.35	GO:0043227	membrane-bounded organelle
0.33	GO:0098805	whole membrane
0.32	GO:1990234	transferase complex
0.32	GO:0044422	organelle part
0.32	GO:0031974	membrane-enclosed lumen
0.32	GO:0019867	outer membrane
0.32	GO:0031975	envelope
0.31	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.37	EC:6	GO:0016874
0.36	KEGG:R03876	GO:0004842

sp|O75683|SURF6_HUMAN
Surfeit locus protein 6
Search

SURF6

0.97

Surfeit 6

0.63	GO:0042254	ribosome biogenesis
0.49	GO:0007507	heart development
0.40	GO:0006357	regulation of transcription by RNA polymerase II
0.38	GO:0022618	ribonucleoprotein complex assembly
0.38	GO:0070925	organelle assembly
0.35	GO:0005975	carbohydrate metabolic process
0.33	GO:0006359	regulation of transcription by RNA polymerase III
0.33	GO:0006383	transcription by RNA polymerase III

0.56	GO:0003723	RNA binding
0.52	GO:0003677	DNA binding
0.42	GO:0001104	RNA polymerase II transcription cofactor activity
0.37	GO:0005515	protein binding
0.36	GO:0016758	transferase activity, transferring hexosyl groups
0.33	GO:0001026	TFIIIB-type transcription factor activity

0.78	GO:0001652	granular component
0.64	GO:0022625	cytosolic large ribosomal subunit
0.63	GO:0005654	nucleoplasm
0.38	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.36

GO:0016758

sp|O75688|PPM1B_HUMAN
Protein phosphatase 1B
Search

sp|O75689|ADAP1_HUMAN
Arf-GAP with dual PH domain-containing protein 1
Search

ADAP1

0.94	Arf-GAP with dual PH domain-containing protein 1

0.76	GO:0043547	positive regulation of GTPase activity
0.38	GO:0048016	inositol phosphate-mediated signaling
0.34	GO:0007166	cell surface receptor signaling pathway
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.83	GO:1902936	phosphatidylinositol bisphosphate binding
0.76	GO:0005096	GTPase activator activity
0.49	GO:0046872	metal ion binding
0.41	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.36	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding
0.33	GO:0004930	G-protein coupled receptor activity
0.33	GO:0005515	protein binding
0.33	GO:0043565	sequence-specific DNA binding
0.33	GO:0003700	DNA binding transcription factor activity

0.48	GO:0005829	cytosol
0.44	GO:0005634	nucleus
0.42	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O75690|KRA58_HUMAN
Keratin-associated protein 5-8
Search

0.80	Keratin-associated protein 5-8

0.45	GO:0031424	keratinization
0.35	GO:0002244	hematopoietic progenitor cell differentiation
0.35	GO:0006952	defense response

0.36	GO:0030280	structural constituent of epidermis
0.34	GO:0005515	protein binding

0.82	GO:0045095	keratin filament
0.40	GO:0005829	cytosol
0.34	GO:0005576	extracellular region

sp|O75691|UTP20_HUMAN
Small subunit processome component 20 homolog
Search

UTP20

0.93	Small subunit processome component 20

0.68	GO:0006364	rRNA processing
0.58	GO:0042274	ribosomal small subunit biogenesis
0.39	GO:0008285	negative regulation of cell proliferation
0.39	GO:0034471	ncRNA 5'-end processing
0.38	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

0.38	GO:0003723	RNA binding
0.36	GO:0005515	protein binding

0.72	GO:0005730	nucleolus
0.63	GO:0030686	90S preribosome
0.61	GO:0032040	small-subunit processome
0.55	GO:0005886	plasma membrane
0.40	GO:0030688	preribosome, small subunit precursor
0.38	GO:0005654	nucleoplasm
0.34	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O75694|NU155_HUMAN
Nuclear pore complex protein Nup155
Search

NUP155

0.79	Nuclear pore complex protein Nup155

0.72	GO:0006913	nucleocytoplasmic transport
0.60	GO:0086026	atrial cardiac muscle cell to AV node cell signaling
0.58	GO:0086002	cardiac muscle cell action potential involved in contraction
0.58	GO:0006998	nuclear envelope organization
0.56	GO:0034504	protein localization to nucleus
0.55	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.54	GO:0017038	protein import
0.53	GO:0072594	establishment of protein localization to organelle
0.53	GO:0051028	mRNA transport
0.49	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

0.80	GO:0017056	structural constituent of nuclear pore
0.35	GO:0005515	protein binding
0.35	GO:0015288	porin activity

0.78	GO:0005643	nuclear pore
0.54	GO:0031965	nuclear membrane
0.35	GO:0046930	pore complex
0.34	GO:0043657	host cell
0.32	GO:0005737	cytoplasm

sp|O75695|XRP2_HUMAN
Protein XRP2
Search

sp|O75711|SCRG1_HUMAN
Scrapie-responsive protein 1
Search

sp|O75712|CXB3_HUMAN
Gap junction beta-3 protein
Search

GJB3

0.64	Gap junction beta-3 protein (Fragment)

0.59	GO:0007154	cell communication
0.51	GO:0001890	placenta development
0.40	GO:0042048	olfactory behavior
0.39	GO:0071300	cellular response to retinoic acid
0.38	GO:0043588	skin development
0.38	GO:0001701	in utero embryonic development
0.38	GO:0007608	sensory perception of smell
0.38	GO:0007283	spermatogenesis
0.33	GO:0055085	transmembrane transport

0.36	GO:0005243	gap junction channel activity
0.33	GO:0005515	protein binding

0.81	GO:0005922	connexin complex
0.42	GO:0043231	intracellular membrane-bounded organelle
0.38	GO:0005737	cytoplasm
0.36	GO:0070013	intracellular organelle lumen
0.35	GO:0043232	intracellular non-membrane-bounded organelle
0.35	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

sp|O75715|GPX5_HUMAN
Epididymal secretory glutathione peroxidase
Search

0.45	Epididymal secretory glutathione peroxidase

0.71	GO:0006979	response to oxidative stress
0.69	GO:0098869	cellular oxidant detoxification
0.53	GO:0055114	oxidation-reduction process
0.48	GO:0051289	protein homotetramerization
0.44	GO:0033554	cellular response to stress
0.42	GO:0042744	hydrogen peroxide catabolic process
0.35	GO:0010269	response to selenium ion
0.35	GO:0051412	response to corticosterone
0.35	GO:0002238	response to molecule of fungal origin
0.34	GO:0006749	glutathione metabolic process

0.79	GO:0004602	glutathione peroxidase activity
0.48	GO:0008430	selenium binding
0.33	GO:0008134	transcription factor binding

0.54	GO:0097524	sperm plasma membrane
0.52	GO:0005615	extracellular space
0.35	GO:1903561	extracellular vesicle
0.30	GO:0016021	integral component of membrane

0.79

EC:1.11.1.9

GO:0004602

sp|O75716|STK16_HUMAN
Serine/threonine-protein kinase 16
Search

STK16

0.92	Serine/threonine-protein kinase 16

0.63	GO:0006468	protein phosphorylation
0.47	GO:0071560	cellular response to transforming growth factor beta stimulus
0.41	GO:0045793	positive regulation of cell size
0.39	GO:0006366	transcription by RNA polymerase II
0.38	GO:0045944	positive regulation of transcription by RNA polymerase II
0.37	GO:0018212	peptidyl-tyrosine modification
0.33	GO:0006413	translational initiation

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.34	GO:0003743	translation initiation factor activity
0.33	GO:0005515	protein binding

0.52	GO:0005798	Golgi-associated vesicle
0.48	GO:0005829	cytosol
0.38	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0016020	membrane

sp|O75717|WDHD1_HUMAN
WD repeat and HMG-box DNA-binding protein 1
Search

WDHD1

0.95	WD repeat and HMG-box DNA-binding protein 1

0.61	GO:0070829	heterochromatin maintenance
0.54	GO:0033044	regulation of chromosome organization
0.47	GO:0006396	RNA processing
0.33	GO:0043043	peptide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process
0.32	GO:0009059	macromolecule biosynthetic process

0.54	GO:0070063	RNA polymerase binding
0.54	GO:0003682	chromatin binding
0.54	GO:0003677	DNA binding
0.45	GO:0003723	RNA binding
0.33	GO:0003735	structural constituent of ribosome

0.59	GO:0005634	nucleus
0.54	GO:0000775	chromosome, centromeric region
0.36	GO:0031974	membrane-enclosed lumen
0.33	GO:0005737	cytoplasm
0.33	GO:0030529	intracellular ribonucleoprotein complex

sp|O75718|CRTAP_HUMAN
Cartilage-associated protein
Search

CRTAP

0.96	Putative membrane-associated proteoglycan leprecan

0.85	GO:0018400	peptidyl-proline hydroxylation to 3-hydroxy-L-proline
0.58	GO:1901874	negative regulation of post-translational protein modification
0.52	GO:0050821	protein stabilization
0.50	GO:0007283	spermatogenesis
0.49	GO:0061077	chaperone-mediated protein folding
0.47	GO:0032964	collagen biosynthetic process
0.46	GO:0017185	peptidyl-lysine hydroxylation
0.45	GO:0046849	bone remodeling
0.45	GO:0030199	collagen fibril organization
0.34	GO:0007130	synaptonemal complex assembly

0.47

GO:0032403

protein complex binding

0.69	GO:0005783	endoplasmic reticulum
0.49	GO:0005615	extracellular space
0.42	GO:0032991	macromolecular complex
0.37	GO:0005578	proteinaceous extracellular matrix
0.36	GO:0000795	synaptonemal complex
0.33	GO:0005730	nucleolus
0.30	GO:0031224	intrinsic component of membrane

sp|O75746|CMC1_HUMAN
Calcium-binding mitochondrial carrier protein Aralar1
Search

SLC25A12

0.89	Calcium-binding mitochondrial carrier protein Aralar1

0.62	GO:0043490	malate-aspartate shuttle
0.60	GO:0089712	L-aspartate transmembrane transport
0.56	GO:0051592	response to calcium ion
0.56	GO:0089711	L-glutamate transmembrane transport
0.38	GO:0006754	ATP biosynthetic process
0.35	GO:0019319	hexose biosynthetic process
0.35	GO:0006006	glucose metabolic process
0.33	GO:0006518	peptide metabolic process
0.33	GO:0043604	amide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process

0.70	GO:0005509	calcium ion binding
0.61	GO:0015183	L-aspartate transmembrane transporter activity
0.56	GO:0005313	L-glutamate transmembrane transporter activity
0.33	GO:0003735	structural constituent of ribosome

0.53	GO:0043209	myelin sheath
0.46	GO:0031966	mitochondrial membrane
0.46	GO:0019866	organelle inner membrane
0.33	GO:0005887	integral component of plasma membrane
0.33	GO:0005840	ribosome

sp|O75747|P3C2G_HUMAN
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Search

PIK3C2G

0.92	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma

0.81	GO:0048015	phosphatidylinositol-mediated signaling
0.75	GO:0046854	phosphatidylinositol phosphorylation
0.52	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
0.44	GO:0016477	cell migration
0.41	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis
0.40	GO:0001525	angiogenesis
0.38	GO:0048268	clathrin coat assembly
0.38	GO:0006897	endocytosis
0.36	GO:0006935	chemotaxis
0.36	GO:0039694	viral RNA genome replication

0.74	GO:0035091	phosphatidylinositol binding
0.72	GO:0035004	phosphatidylinositol 3-kinase activity
0.62	GO:0016307	phosphatidylinositol phosphate kinase activity
0.52	GO:0052742	phosphatidylinositol kinase activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003735	structural constituent of ribosome

0.45	GO:0005942	phosphatidylinositol 3-kinase complex
0.45	GO:0005622	intracellular
0.38	GO:0005886	plasma membrane
0.38	GO:0031982	vesicle
0.32	GO:1990904	ribonucleoprotein complex
0.32	GO:0043228	non-membrane-bounded organelle

0.72

GO:0035004

sp|O75751|S22A3_HUMAN
Solute carrier family 22 member 3
Search

SLC22A3

0.94	Organic cation transporter 3

0.60	GO:0051615	histamine uptake
0.59	GO:0015844	monoamine transport
0.57	GO:0032098	regulation of appetite
0.56	GO:0015695	organic cation transport
0.55	GO:0055085	transmembrane transport
0.49	GO:0015850	organic hydroxy compound transport
0.46	GO:0015893	drug transport
0.44	GO:0015711	organic anion transport
0.41	GO:1901374	acetate ester transport
0.39	GO:1901998	toxin transport

0.60	GO:0015651	quaternary ammonium group transmembrane transporter activity
0.54	GO:0005329	dopamine transmembrane transporter activity
0.45	GO:0008514	organic anion transmembrane transporter activity
0.41	GO:0008513	secondary active organic cation transmembrane transporter activity
0.41	GO:0005333	norepinephrine transmembrane transporter activity
0.41	GO:0005277	acetylcholine transmembrane transporter activity
0.40	GO:0019534	toxin transmembrane transporter activity
0.35	GO:0005515	protein binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding

0.45	GO:0005887	integral component of plasma membrane
0.34	GO:0070062	extracellular exosome
0.34	GO:0098793	presynapse

sp|O75752|B3GL1_HUMAN
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
Search

B3GALNT1

0.50	Hexosyltransferase

0.74	GO:0006486	protein glycosylation
0.49	GO:0009312	oligosaccharide biosynthetic process
0.36	GO:0006687	glycosphingolipid metabolic process
0.33	GO:0006400	tRNA modification

0.80	GO:0008378	galactosyltransferase activity
0.51	GO:0008194	UDP-glycosyltransferase activity
0.33	GO:0016763	transferase activity, transferring pentosyl groups
0.33	GO:0008270	zinc ion binding

0.72	GO:0000139	Golgi membrane
0.30	GO:0031224	intrinsic component of membrane

0.80

GO:0008378

sp|O75762|TRPA1_HUMAN
Transient receptor potential cation channel subfamily A member 1
Search

TRPA1

0.96	Transient receptor potential ankyrin 1

0.60	GO:0034220	ion transmembrane transport
0.59	GO:0050955	thermoception
0.58	GO:0050968	detection of chemical stimulus involved in sensory perception of pain
0.57	GO:0050974	detection of mechanical stimulus involved in sensory perception
0.55	GO:0048265	response to pain
0.53	GO:0051289	protein homotetramerization
0.53	GO:0051283	negative regulation of sequestering of calcium ion
0.53	GO:0042542	response to hydrogen peroxide
0.53	GO:0060402	calcium ion transport into cytosol
0.52	GO:0009409	response to cold

0.70	GO:0005216	ion channel activity
0.51	GO:0022834	ligand-gated channel activity
0.50	GO:0015085	calcium ion transmembrane transporter activity
0.49	GO:0042802	identical protein binding
0.45	GO:0004871	signal transducer activity
0.35	GO:0022832	voltage-gated channel activity
0.34	GO:0099600	transmembrane receptor activity

0.54	GO:0032421	stereocilium bundle
0.46	GO:0005887	integral component of plasma membrane
0.35	GO:0016324	apical plasma membrane
0.35	GO:0030424	axon

sp|O75764|TCEA3_HUMAN
Transcription elongation factor A protein 3
Search

TCEA3

0.95	Tissue-specific transcription factor S-II

0.57	GO:0097659	nucleic acid-templated transcription
0.56	GO:0006414	translational elongation
0.54	GO:1903506	regulation of nucleic acid-templated transcription
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:0010468	regulation of gene expression

0.61	GO:0008270	zinc ion binding
0.57	GO:0003746	translation elongation factor activity
0.35	GO:0003677	DNA binding

0.60

GO:0005634

nucleus

sp|O75771|RA51D_HUMAN
DNA repair protein RAD51 homolog 4
Search

RAD51D

0.94	Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

0.65	GO:0006281	DNA repair
0.62	GO:0042148	strand invasion
0.54	GO:0000723	telomere maintenance
0.51	GO:0051726	regulation of cell cycle
0.49	GO:0090735	DNA repair complex assembly
0.49	GO:0006312	mitotic recombination
0.48	GO:0010212	response to ionizing radiation
0.48	GO:0007131	reciprocal meiotic recombination
0.46	GO:0065004	protein-DNA complex assembly
0.40	GO:1900426	positive regulation of defense response to bacterium

0.69	GO:0008094	DNA-dependent ATPase activity
0.60	GO:0000400	four-way junction DNA binding
0.56	GO:0043015	gamma-tubulin binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0003697	single-stranded DNA binding
0.45	GO:0000150	recombinase activity
0.44	GO:0004520	endodeoxyribonuclease activity
0.44	GO:0003690	double-stranded DNA binding

0.60	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex
0.56	GO:0000784	nuclear chromosome, telomeric region
0.54	GO:0005813	centrosome
0.53	GO:0005657	replication fork
0.39	GO:0005737	cytoplasm
0.34	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

sp|O75781|PALM_HUMAN
Paralemmin-1
Search

PALM

0.97	Paralemmin

0.69	GO:0008360	regulation of cell shape
0.61	GO:0071257	cellular response to electrical stimulus
0.61	GO:0060074	synapse maturation
0.60	GO:0060160	negative regulation of dopamine receptor signaling pathway
0.59	GO:0007194	negative regulation of adenylate cyclase activity
0.58	GO:0051491	positive regulation of filopodium assembly
0.58	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.57	GO:0072659	protein localization to plasma membrane
0.51	GO:0007010	cytoskeleton organization
0.41	GO:0060999	positive regulation of dendritic spine development

0.63	GO:0031750	D3 dopamine receptor binding
0.34	GO:0016301	kinase activity

0.59	GO:0031527	filopodium membrane
0.58	GO:0044309	neuron spine
0.57	GO:0014069	postsynaptic density
0.46	GO:0005634	nucleus
0.44	GO:0016327	apicolateral plasma membrane
0.43	GO:0016323	basolateral plasma membrane
0.43	GO:0030425	dendrite
0.42	GO:0030424	axon
0.42	GO:0032589	neuron projection membrane
0.42	GO:0097060	synaptic membrane

sp|O75783|RHBL1_HUMAN
Rhomboid-related protein 1
Search

RHBDL1

0.78	Rhomboid-related protein 1

0.64	GO:0016485	protein processing
0.46	GO:0007165	signal transduction

0.69	GO:0004252	serine-type endopeptidase activity
0.49	GO:0005509	calcium ion binding
0.48	GO:0003924	GTPase activity
0.47	GO:0005525	GTP binding

0.49

GO:0005887

integral component of plasma membrane

0.69

GO:0004252

sp|O75787|RENR_HUMAN
Renin receptor
Search

ATP6AP2

0.86	ATPase H+ transporting accessory protein 2

0.73	GO:0032914	positive regulation of transforming growth factor beta1 production
0.70	GO:0021903	rostrocaudal neural tube patterning
0.70	GO:0002003	angiotensin maturation
0.70	GO:0048069	eye pigmentation
0.69	GO:0060323	head morphogenesis
0.67	GO:0030177	positive regulation of Wnt signaling pathway
0.63	GO:0043408	regulation of MAPK cascade
0.51	GO:0035622	intrahepatic bile duct development

0.65	GO:0004872	receptor activity
0.30	GO:0003824	catalytic activity

0.65	GO:0009897	external side of plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O75791|GRAP2_HUMAN
GRB2-related adapter protein 2
Search

GRAP2

0.97	growth factor receptor-bound protein 2-like isoform X1

0.63	GO:0038083	peptidyl-tyrosine autophosphorylation
0.58	GO:0045087	innate immune response
0.58	GO:0016477	cell migration
0.58	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.57	GO:0042127	regulation of cell proliferation
0.54	GO:0030154	cell differentiation
0.52	GO:0007265	Ras protein signal transduction
0.41	GO:0038095	Fc-epsilon receptor signaling pathway
0.41	GO:0031295	T cell costimulation
0.40	GO:0050852	T cell receptor signaling pathway

0.60	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.55	GO:0005102	receptor binding
0.40	GO:0005070	SH3/SH2 adaptor activity
0.33	GO:0043565	sequence-specific DNA binding
0.33	GO:0003700	DNA binding transcription factor activity
0.33	GO:0005096	GTPase activator activity
0.32	GO:0015075	ion transmembrane transporter activity

0.70	GO:0005768	endosome
0.59	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.58	GO:0005634	nucleus
0.37	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.60

EC:2.7.10.2

GO:0004715

sp|O75792|RNH2A_HUMAN
Ribonuclease H2 subunit A
Search

RNASEH2A

0.55	Ribonuclease

0.70	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.56	GO:0006298	mismatch repair
0.54	GO:0006401	RNA catabolic process
0.51	GO:0033567	DNA replication, Okazaki fragment processing
0.38	GO:0045005	DNA-dependent DNA replication maintenance of fidelity
0.35	GO:0007010	cytoskeleton organization
0.34	GO:0006468	protein phosphorylation
0.34	GO:0035556	intracellular signal transduction
0.33	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.33	GO:0006289	nucleotide-excision repair

0.74	GO:0004523	RNA-DNA hybrid ribonuclease activity
0.59	GO:0003723	RNA binding
0.36	GO:0046872	metal ion binding
0.35	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003684	damaged DNA binding

0.62	GO:0032299	ribonuclease H2 complex
0.50	GO:0005654	nucleoplasm
0.50	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.74

EC:3.1.26.4

GO:0004523

sp|O75794|CD123_HUMAN
Cell division cycle protein 123 homolog
Search

CDC123

0.97	Cell division cycle protein 123 homolog

0.67	GO:0007049	cell cycle
0.63	GO:0051301	cell division
0.47	GO:0045786	negative regulation of cell cycle
0.45	GO:0006417	regulation of translation
0.38	GO:1905143	eukaryotic translation initiation factor 2 complex assembly
0.36	GO:0034250	positive regulation of cellular amide metabolic process
0.36	GO:0032270	positive regulation of cellular protein metabolic process
0.35	GO:0010557	positive regulation of macromolecule biosynthetic process
0.35	GO:0031328	positive regulation of cellular biosynthetic process
0.35	GO:0010628	positive regulation of gene expression

0.34	GO:0000287	magnesium ion binding
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0008144	drug binding

0.44

GO:0005737

cytoplasm

sp|O75795|UDB17_HUMAN
UDP-glucuronosyltransferase 2B17
Search

0.54	UDP-glucuronosyltransferase

0.52	GO:0052695	cellular glucuronidation
0.40	GO:0008202	steroid metabolic process
0.38	GO:0006805	xenobiotic metabolic process
0.38	GO:0034754	cellular hormone metabolic process
0.37	GO:0018879	biphenyl metabolic process
0.37	GO:0071394	cellular response to testosterone stimulus
0.36	GO:0071361	cellular response to ethanol
0.36	GO:0071378	cellular response to growth hormone stimulus
0.36	GO:0071385	cellular response to glucocorticoid stimulus
0.36	GO:0032496	response to lipopolysaccharide

0.80	GO:0015020	glucuronosyltransferase activity
0.41	GO:0001972	retinoic acid binding

0.43	GO:0005789	endoplasmic reticulum membrane
0.40	GO:0031090	organelle membrane
0.34	GO:0070062	extracellular exosome
0.34	GO:0005635	nuclear envelope
0.33	GO:0098805	whole membrane
0.33	GO:0019867	outer membrane
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.80

EC:2.4.1.17

GO:0015020

sp|O75800|ZMY10_HUMAN
Zinc finger MYND domain-containing protein 10
Search

ZMYND10

0.96	Zinc finger MYND domain-containing protein 10

0.85	GO:0036158	outer dynein arm assembly
0.79	GO:0036159	inner dynein arm assembly
0.78	GO:0044458	motile cilium assembly
0.37	GO:0007165	signal transduction

0.51	GO:0046872	metal ion binding
0.36	GO:0005515	protein binding

0.49	GO:0034451	centriolar satellite
0.36	GO:0005929	cilium

sp|O75807|PR15A_HUMAN
Protein phosphatase 1 regulatory subunit 15A
Search

PPP1R15A

0.68	Protein phosphatase 1 regulatory subunit 15A

0.86	GO:1903917	positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
0.86	GO:0036496	regulation of translational initiation by eIF2 alpha dephosphorylation
0.86	GO:1902310	positive regulation of peptidyl-serine dephosphorylation
0.84	GO:0032516	positive regulation of phosphoprotein phosphatase activity
0.77	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.75	GO:0034976	response to endoplasmic reticulum stress
0.70	GO:0070972	protein localization to endoplasmic reticulum
0.58	GO:0006915	apoptotic process
0.55	GO:0060734	regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
0.53	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

0.81	GO:0008157	protein phosphatase 1 binding
0.73	GO:0019901	protein kinase binding
0.48	GO:0019888	protein phosphatase regulator activity
0.30	GO:0008047	enzyme activator activity

0.78	GO:0000164	protein phosphatase type 1 complex
0.70	GO:0005783	endoplasmic reticulum
0.67	GO:0005794	Golgi apparatus
0.61	GO:0005739	mitochondrion
0.57	GO:0031968	organelle outer membrane
0.54	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.52	GO:0031984	organelle subcompartment
0.36	GO:0005829	cytosol
0.30	GO:0044425	membrane part

sp|O75808|CAN15_HUMAN
Calpain-15
Search

CAPN15

0.96	Small optic lobes homolog

0.60	GO:0006508	proteolysis
0.34	GO:0016567	protein ubiquitination
0.34	GO:2001141	regulation of RNA biosynthetic process
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression
0.33	GO:0032456	endocytic recycling
0.33	GO:0055114	oxidation-reduction process
0.32	GO:0000910	cytokinesis

0.81	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.53	GO:0046872	metal ion binding
0.34	GO:0003700	DNA binding transcription factor activity
0.34	GO:0004842	ubiquitin-protein transferase activity
0.34	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.33	GO:0030306	ADP-ribosylation factor binding
0.33	GO:0017137	Rab GTPase binding

0.45	GO:0005622	intracellular
0.30	GO:0016020	membrane

0.34	EC:1.14	GO:0016705
0.34	KEGG:R03876	GO:0004842

sp|O75815|BCAR3_HUMAN
Breast cancer anti-estrogen resistance protein 3
Search

BCAR3

0.96	Breast cancer anti-estrogen resistance protein 3

0.75	GO:0007264	small GTPase mediated signal transduction
0.65	GO:0065009	regulation of molecular function
0.58	GO:0002089	lens morphogenesis in camera-type eye
0.56	GO:0033138	positive regulation of peptidyl-serine phosphorylation
0.45	GO:0009967	positive regulation of signal transduction
0.34	GO:0042493	response to drug

0.74	GO:0005085	guanyl-nucleotide exchange factor activity
0.48	GO:0005070	SH3/SH2 adaptor activity

0.44

GO:0005622

intracellular

sp|O75817|POP7_HUMAN
Ribonuclease P protein subunit p20
Search

POP7

0.97	Ribonuclease P protein subunit like protein (Fragment)

0.70	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.66	GO:0008033	tRNA processing

0.78	GO:0004526	ribonuclease P activity
0.51	GO:0003676	nucleic acid binding
0.34	GO:0005515	protein binding

0.71	GO:0005730	nucleolus
0.62	GO:0030681	multimeric ribonuclease P complex
0.61	GO:0000172	ribonuclease MRP complex
0.44	GO:0005737	cytoplasm
0.35	GO:0005654	nucleoplasm

0.78

EC:3.1.26.5

GO:0004526

sp|O75818|RPP40_HUMAN
Ribonuclease P protein subunit p40
Search

RPP40

0.96	Ribonuclease P protein subunit p40

0.68	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.60	GO:0001682	tRNA 5'-leader removal
0.48	GO:0006364	rRNA processing

0.76

GO:0004526

ribonuclease P activity

0.66	GO:0005730	nucleolus
0.64	GO:0030681	multimeric ribonuclease P complex
0.48	GO:0005654	nucleoplasm

0.76

EC:3.1.26.5

GO:0004526

sp|O75820|ZN189_HUMAN
Zinc finger protein 189
Search

ZNF189

0.80	Zinc finger protein 7

0.52	GO:1903506	regulation of nucleic acid-templated transcription
0.52	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.52	GO:0010468	regulation of gene expression
0.41	GO:0044791	positive regulation by host of viral release from host cell
0.36	GO:1902679	negative regulation of RNA biosynthetic process
0.35	GO:0006351	transcription, DNA-templated

0.51	GO:0003676	nucleic acid binding
0.49	GO:0046872	metal ion binding
0.42	GO:0003700	DNA binding transcription factor activity

0.43	GO:0005622	intracellular
0.37	GO:0043227	membrane-bounded organelle
0.30	GO:0016020	membrane

sp|O75821|EIF3G_HUMAN
Eukaryotic translation initiation factor 3 subunit G
Search

EIF3G

0.70	Eukaryotic translation initiation factor 3 subunit G-A

0.72	GO:0001731	formation of translation preinitiation complex
0.71	GO:0006446	regulation of translational initiation
0.56	GO:0075525	viral translational termination-reinitiation
0.34	GO:0090116	C-5 methylation of cytosine
0.32	GO:0006508	proteolysis

0.72	GO:0003743	translation initiation factor activity
0.34	GO:0005515	protein binding
0.34	GO:0003886	DNA (cytosine-5-)-methyltransferase activity
0.34	GO:0003682	chromatin binding
0.33	GO:0008270	zinc ion binding
0.33	GO:0004252	serine-type endopeptidase activity
0.32	GO:0003677	DNA binding

0.78	GO:0005852	eukaryotic translation initiation factor 3 complex
0.72	GO:0016282	eukaryotic 43S preinitiation complex
0.72	GO:0033290	eukaryotic 48S preinitiation complex
0.60	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0005634	nucleus
0.47	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.34

EC:2.1.1.37

GO:0003886

sp|O75822|EIF3J_HUMAN
Eukaryotic translation initiation factor 3 subunit J
Search

EIF3J

0.73	Eukaryotic translation initiation factor 3 subunit J-A

0.71	GO:0006413	translational initiation
0.67	GO:0002181	cytoplasmic translation
0.67	GO:0006446	regulation of translational initiation
0.63	GO:0022618	ribonucleoprotein complex assembly
0.35	GO:0016311	dephosphorylation
0.34	GO:1903507	negative regulation of nucleic acid-templated transcription

0.71	GO:0003743	translation initiation factor activity
0.35	GO:0016791	phosphatase activity
0.34	GO:0003714	transcription corepressor activity
0.33	GO:0005515	protein binding

0.77	GO:0005852	eukaryotic translation initiation factor 3 complex
0.67	GO:0016282	eukaryotic 43S preinitiation complex
0.67	GO:0033290	eukaryotic 48S preinitiation complex
0.46	GO:0005829	cytosol

0.35

EC:3.1.3 EC:3.1.3.41

GO:0016791

sp|O75828|CBR3_HUMAN
Carbonyl reductase [NADPH] 3
Search

0.76	Carbonyl reductase

0.52	GO:0055114	oxidation-reduction process
0.51	GO:0050890	cognition
0.49	GO:0042373	vitamin K metabolic process
0.43	GO:0030855	epithelial cell differentiation
0.43	GO:1901662	quinone catabolic process
0.41	GO:0042374	phylloquinone metabolic process
0.39	GO:0009111	vitamin catabolic process
0.39	GO:0017144	drug metabolic process
0.36	GO:0006692	prostanoid metabolic process
0.35	GO:1901523	icosanoid catabolic process

0.61	GO:0004090	carbonyl reductase (NADPH) activity
0.50	GO:0070402	NADPH binding
0.44	GO:0047021	15-hydroxyprostaglandin dehydrogenase (NADP+) activity
0.44	GO:0050221	prostaglandin-E2 9-reductase activity
0.41	GO:0000253	3-keto sterol reductase activity
0.40	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
0.35	GO:0005515	protein binding
0.33	GO:0003735	structural constituent of ribosome

0.46	GO:0005654	nucleoplasm
0.46	GO:0005829	cytosol
0.37	GO:0005615	extracellular space
0.36	GO:1903561	extracellular vesicle
0.34	GO:0005902	microvillus
0.33	GO:0005840	ribosome
0.32	GO:0005886	plasma membrane

0.61	EC:1.1.1.184	GO:0004090
0.44	KEGG:R04552	GO:0047021

sp|O75829|LECT1_HUMAN
Leukocyte cell-derived chemotaxin 1
Search

CNMD

0.97	Leukocyte cell-derived chemotaxin 1

0.63	GO:0016525	negative regulation of angiogenesis
0.44	GO:0051216	cartilage development
0.41	GO:0030154	cell differentiation
0.41	GO:0007585	respiratory gaseous exchange
0.39	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
0.39	GO:0001937	negative regulation of endothelial cell proliferation
0.39	GO:0003158	endothelium development
0.37	GO:0000902	cell morphogenesis
0.36	GO:0006029	proteoglycan metabolic process
0.36	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

0.35

GO:0005509

calcium ion binding

0.42	GO:0005578	proteinaceous extracellular matrix
0.40	GO:0012505	endomembrane system
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O75830|SPI2_HUMAN
Serpin I2
Search

SERPINI2

0.86	Serine (Or cysteine) peptidase inhibitor, clade I, member 2

0.54	GO:0010951	negative regulation of endopeptidase activity
0.40	GO:0030155	regulation of cell adhesion
0.37	GO:0042270	protection from natural killer cell mediated cytotoxicity
0.36	GO:0002448	mast cell mediated immunity
0.36	GO:0033668	negative regulation by symbiont of host apoptotic process
0.36	GO:0071391	cellular response to estrogen stimulus
0.36	GO:0006508	proteolysis
0.36	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.35	GO:0043066	negative regulation of apoptotic process
0.35	GO:0006915	apoptotic process

0.56	GO:0004867	serine-type endopeptidase inhibitor activity
0.36	GO:0008233	peptidase activity
0.36	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.36	GO:0002020	protease binding
0.35	GO:0008270	zinc ion binding
0.33	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0004721	phosphoprotein phosphatase activity

0.73	GO:0005615	extracellular space
0.39	GO:1903561	extracellular vesicle
0.34	GO:0005794	Golgi apparatus
0.34	GO:0005654	nucleoplasm
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.36

GO:0008233

sp|O75832|PSD10_HUMAN
26S proteasome non-ATPase regulatory subunit 10
Search

PSMD10

0.87	Ankyrin repeat domain-containing protein 16

0.58	GO:0007253	cytoplasmic sequestering of NF-kappaB
0.57	GO:0090201	negative regulation of release of cytochrome c from mitochondria
0.57	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
0.55	GO:0032088	negative regulation of NF-kappaB transcription factor activity
0.55	GO:0070682	proteasome regulatory particle assembly
0.55	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
0.55	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.54	GO:0030307	positive regulation of cell growth
0.53	GO:0043409	negative regulation of MAPK cascade
0.53	GO:0031398	positive regulation of protein ubiquitination

0.49

GO:0008134

transcription factor binding

0.70	GO:1905369	endopeptidase complex
0.57	GO:0043234	protein complex
0.51	GO:0045111	intermediate filament cytoskeleton
0.47	GO:0005829	cytosol
0.44	GO:0005634	nucleus
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part

sp|O75838|CIB2_HUMAN
Calcium and integrin-binding family member 2
Search

CIB2

0.97	DNA-dependent protein kinase catalytic subunit-interacting protein 2

0.65	GO:0007229	integrin-mediated signaling pathway
0.57	GO:0071318	cellular response to ATP
0.53	GO:0045494	photoreceptor cell maintenance
0.53	GO:0055074	calcium ion homeostasis
0.52	GO:0072503	cellular divalent inorganic cation homeostasis
0.49	GO:0006875	cellular metal ion homeostasis
0.41	GO:0007638	mechanosensory behavior
0.41	GO:0048884	neuromast development
0.40	GO:0043010	camera-type eye development
0.37	GO:0007602	phototransduction

0.70	GO:0005509	calcium ion binding
0.52	GO:0005178	integrin binding
0.50	GO:0042803	protein homodimerization activity
0.46	GO:0000287	magnesium ion binding
0.35	GO:0016301	kinase activity
0.34	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity
0.32	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.57	GO:0032437	cuticular plate
0.54	GO:0005927	muscle tendon junction
0.54	GO:0032420	stereocilium
0.54	GO:0001917	photoreceptor inner segment
0.53	GO:0001750	photoreceptor outer segment
0.52	GO:0042383	sarcolemma
0.52	GO:0031594	neuromuscular junction
0.37	GO:0072562	blood microparticle
0.34	GO:0005955	calcineurin complex

0.32

GO:0016773

sp|O75840|KLF7_HUMAN
Krueppel-like factor 7
Search

KLF7

0.97	Kruppel like factor 7

0.56	GO:0048813	dendrite morphogenesis
0.54	GO:0007411	axon guidance
0.52	GO:0006366	transcription by RNA polymerase II
0.52	GO:0045944	positive regulation of transcription by RNA polymerase II
0.37	GO:0021634	optic nerve formation

0.55	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.55	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.36	GO:0001158	enhancer sequence-specific DNA binding
0.35	GO:0003713	transcription coactivator activity
0.33	GO:0046872	metal ion binding

0.35	GO:0005634	nucleus
0.33	GO:0005829	cytosol
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.32	GO:0044446	intracellular organelle part

sp|O75841|UPK1B_HUMAN
Uroplakin-1b
Search

UPK1B

0.59	Tetraspanin

0.57	GO:0030855	epithelial cell differentiation
0.44	GO:0007166	cell surface receptor signaling pathway
0.36	GO:0034394	protein localization to cell surface

0.35	GO:0005515	protein binding
0.34	GO:0005198	structural molecule activity

0.58	GO:0016324	apical plasma membrane
0.42	GO:0005887	integral component of plasma membrane
0.37	GO:0070062	extracellular exosome
0.34	GO:0005783	endoplasmic reticulum

sp|O75843|AP1G2_HUMAN
AP-1 complex subunit gamma-like 2
Search

AP1G2

0.83	AP-1 complex subunit gamma-1

0.68	GO:0006886	intracellular protein transport
0.68	GO:0016192	vesicle-mediated transport
0.45	GO:0043323	positive regulation of natural killer cell degranulation
0.45	GO:0035646	endosome to melanosome transport
0.43	GO:0007041	lysosomal transport
0.42	GO:0016482	cytosolic transport
0.35	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.35	GO:0032438	melanosome organization
0.35	GO:0016032	viral process
0.33	GO:0006518	peptide metabolic process

0.44	GO:0030742	GTP-dependent protein binding
0.43	GO:0019894	kinesin binding
0.42	GO:0017137	Rab GTPase binding
0.42	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0005215	transporter activity

0.77	GO:0030131	clathrin adaptor complex
0.67	GO:0005794	Golgi apparatus
0.53	GO:0031410	cytoplasmic vesicle
0.39	GO:0005829	cytosol
0.38	GO:0012506	vesicle membrane
0.37	GO:0098805	whole membrane
0.37	GO:0098588	bounding membrane of organelle
0.36	GO:0031984	organelle subcompartment
0.34	GO:0005764	lysosome
0.34	GO:0044437	vacuolar part

0.42

EC:3.2.1

GO:0004553

sp|O75844|FACE1_HUMAN
CAAX prenyl protease 1 homolog
Search

ZMPSTE24

0.75	Zinc metallopeptidase

0.83	GO:0071586	CAAX-box protein processing
0.58	GO:0030327	prenylated protein catabolic process
0.54	GO:0006998	nuclear envelope organization
0.34	GO:0033184	positive regulation of histone ubiquitination
0.34	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.34	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
0.34	GO:0033169	histone H3-K9 demethylation
0.34	GO:0034720	histone H3-K4 demethylation
0.34	GO:0071480	cellular response to gamma radiation
0.34	GO:0010569	regulation of double-strand break repair via homologous recombination

0.70	GO:0004222	metalloendopeptidase activity
0.35	GO:0061752	telomeric repeat-containing RNA binding
0.35	GO:0043426	MRF binding
0.35	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)
0.34	GO:0032454	histone demethylase activity (H3-K9 specific)
0.34	GO:0050681	androgen receptor binding
0.34	GO:0008235	metalloexopeptidase activity
0.34	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
0.34	GO:0002039	p53 binding
0.34	GO:0042162	telomeric DNA binding

0.47	GO:0030176	integral component of endoplasmic reticulum membrane
0.37	GO:0005637	nuclear inner membrane
0.36	GO:0070062	extracellular exosome
0.34	GO:0000784	nuclear chromosome, telomeric region
0.33	GO:1990391	DNA repair complex
0.33	GO:0000790	nuclear chromatin
0.33	GO:0005654	nucleoplasm
0.32	GO:0043234	protein complex

0.70

GO:0004222

sp|O75845|SC5D_HUMAN
Lathosterol oxidase
Search

SC5D

0.93	Lathosterol oxidase

0.65	GO:0008610	lipid biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.52	GO:1902653	secondary alcohol biosynthetic process
0.52	GO:0016125	sterol metabolic process
0.46	GO:0001878	response to yeast
0.44	GO:0044108	cellular alcohol biosynthetic process
0.44	GO:0016128	phytosteroid metabolic process
0.41	GO:1901362	organic cyclic compound biosynthetic process
0.40	GO:0044255	cellular lipid metabolic process
0.36	GO:0007605	sensory perception of sound

0.63	GO:0005506	iron ion binding
0.58	GO:0000248	C-5 sterol desaturase activity
0.53	GO:0050046	lathosterol oxidase activity
0.36	GO:0005201	extracellular matrix structural constituent
0.33	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
0.32	GO:0003723	RNA binding

0.49	GO:0044432	endoplasmic reticulum part
0.45	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.43	GO:0031984	organelle subcompartment
0.40	GO:0043233	organelle lumen
0.35	GO:0005578	proteinaceous extracellular matrix
0.30	GO:0016021	integral component of membrane

0.53

EC:1.14.21.6

GO:0050046

sp|O75864|PPR37_HUMAN
Protein phosphatase 1 regulatory subunit 37
Search

PPP1R37

0.95	Leucine-rich repeat-containing protein 68

0.80	GO:0010923	negative regulation of phosphatase activity
0.53	GO:0035308	negative regulation of protein dephosphorylation
0.52	GO:0043666	regulation of phosphoprotein phosphatase activity
0.38	GO:0009966	regulation of signal transduction
0.37	GO:0030010	establishment of cell polarity
0.36	GO:0000226	microtubule cytoskeleton organization
0.35	GO:0007186	G-protein coupled receptor signaling pathway
0.35	GO:0006468	protein phosphorylation
0.34	GO:0035556	intracellular signal transduction

0.54	GO:0004864	protein phosphatase inhibitor activity
0.41	GO:0005515	protein binding
0.38	GO:0030545	receptor regulator activity
0.35	GO:0004674	protein serine/threonine kinase activity
0.34	GO:0004871	signal transducer activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.37	GO:0005576	extracellular region
0.36	GO:1905360	GTPase complex
0.36	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.34	GO:0098797	plasma membrane protein complex
0.34	GO:0034719	SMN-Sm protein complex
0.30	GO:0016021	integral component of membrane

0.35

GO:0004674

sp|O75865|TPC6A_HUMAN
Trafficking protein particle complex subunit 6A
Search

TRAPPC6A

0.89	Trafficking protein particle complex subunit 6A

0.76	GO:0048193	Golgi vesicle transport
0.75	GO:0043087	regulation of GTPase activity
0.51	GO:1903232	melanosome assembly
0.44	GO:0046907	intracellular transport
0.36	GO:0006900	vesicle budding from membrane
0.36	GO:0006903	vesicle targeting
0.34	GO:0006461	protein complex assembly
0.33	GO:0016925	protein sumoylation
0.32	GO:0034613	cellular protein localization
0.32	GO:0015031	protein transport

0.36	GO:0017112	Rab guanyl-nucleotide exchange factor activity
0.33	GO:0019789	SUMO transferase activity
0.32	GO:0008270	zinc ion binding

0.48	GO:0005801	cis-Golgi network
0.48	GO:0030008	TRAPP complex
0.47	GO:0005802	trans-Golgi network
0.37	GO:0005783	endoplasmic reticulum
0.35	GO:0000139	Golgi membrane
0.34	GO:0005829	cytosol
0.33	GO:0030127	COPII vesicle coat

sp|O75871|CEAM4_HUMAN
Carcinoembryonic antigen-related cell adhesion molecule 4
Search

CEACAM4

0.96	Carcinoembryonic antigen-related cell adhesion molecule 4

0.52	GO:0007565	female pregnancy
0.44	GO:0006909	phagocytosis
0.40	GO:0016477	cell migration
0.38	GO:0043312	neutrophil degranulation
0.38	GO:0030334	regulation of cell migration
0.38	GO:0043317	regulation of cytotoxic T cell degranulation
0.37	GO:0002859	negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
0.37	GO:0001915	negative regulation of T cell mediated cytotoxicity
0.37	GO:0043301	negative regulation of leukocyte degranulation
0.37	GO:0050860	negative regulation of T cell receptor signaling pathway

0.37	GO:0031005	filamin binding
0.36	GO:1990782	protein tyrosine kinase binding
0.36	GO:0019903	protein phosphatase binding
0.35	GO:0042803	protein homodimerization activity
0.35	GO:0003779	actin binding

0.39	GO:0005576	extracellular region
0.38	GO:0030667	secretory granule membrane
0.37	GO:0042581	specific granule
0.37	GO:0044459	plasma membrane part
0.36	GO:0031225	anchored component of membrane
0.35	GO:0043235	receptor complex
0.35	GO:0005911	cell-cell junction
0.35	GO:0009986	cell surface
0.35	GO:0005766	primary lysosome
0.34	GO:0005765	lysosomal membrane

sp|O75874|IDHC_HUMAN
Isocitrate dehydrogenase [NADP] cytoplasmic
Search

IDH1

0.49	Isocitrate dehydrogenase [NADP] cytoplasmic

0.81	GO:0006102	isocitrate metabolic process
0.60	GO:0006099	tricarboxylic acid cycle
0.53	GO:0006103	2-oxoglutarate metabolic process
0.53	GO:0060696	regulation of phospholipid catabolic process
0.51	GO:0071071	regulation of phospholipid biosynthetic process
0.47	GO:0006749	glutathione metabolic process
0.45	GO:0006979	response to oxidative stress
0.42	GO:0048513	animal organ development
0.41	GO:0006097	glyoxylate cycle
0.40	GO:0002520	immune system development

0.78	GO:0004450	isocitrate dehydrogenase (NADP+) activity
0.67	GO:0051287	NAD binding
0.64	GO:0000287	magnesium ion binding
0.52	GO:0045296	cadherin binding
0.49	GO:0042803	protein homodimerization activity
0.48	GO:0005102	receptor binding
0.39	GO:0051990	(R)-2-hydroxyglutarate dehydrogenase activity
0.36	GO:0050661	NADP binding

0.50	GO:0005777	peroxisome
0.47	GO:0005829	cytosol
0.41	GO:0005739	mitochondrion
0.36	GO:0070062	extracellular exosome
0.35	GO:1904724	tertiary granule lumen
0.35	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0034774	secretory granule lumen
0.35	GO:0031907	microbody lumen

0.78

EC:1.1.1.42

GO:0004450

sp|O75879|GATB_HUMAN
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
Search

GATB

0.72	Glutamyl-tRNA amidotransferase subunit B

0.75	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation
0.71	GO:0032543	mitochondrial translation

0.71	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor
0.58	GO:0140101	catalytic activity, acting on a tRNA
0.50	GO:0032559	adenyl ribonucleotide binding
0.49	GO:0008144	drug binding
0.49	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0016740	transferase activity
0.34	GO:0008135	translation factor activity, RNA binding

0.69	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex
0.55	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

0.71

EC:6.3.5

GO:0016884

sp|O75880|SCO1_HUMAN
Protein SCO1 homolog, mitochondrial
Search

SCO1

0.97	SCO cytochrome oxidase deficient homolog 1

0.77	GO:0008535	respiratory chain complex IV assembly
0.75	GO:0006878	cellular copper ion homeostasis
0.71	GO:0006825	copper ion transport
0.60	GO:1901799	negative regulation of proteasomal protein catabolic process
0.59	GO:0097034	mitochondrial respiratory chain complex IV biogenesis
0.57	GO:0033108	mitochondrial respiratory chain complex assembly
0.54	GO:0045454	cell redox homeostasis
0.34	GO:0007018	microtubule-based movement
0.34	GO:0006091	generation of precursor metabolites and energy
0.33	GO:0006629	lipid metabolic process

0.66	GO:0005507	copper ion binding
0.35	GO:0005515	protein binding
0.34	GO:0003777	microtubule motor activity
0.34	GO:0044877	macromolecular complex binding
0.33	GO:0052689	carboxylic ester hydrolase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.66	GO:0072492	host cell mitochondrial intermembrane space
0.58	GO:0030016	myofibril
0.58	GO:0005739	mitochondrion
0.57	GO:0019866	organelle inner membrane
0.34	GO:0016459	myosin complex
0.34	GO:0005581	collagen trimer
0.33	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.33	EC:3.1.1 EC:3.1.1.1	GO:0052689
0.33	KEGG:R00630	GO:0052689

sp|O75881|CP7B1_HUMAN
25-hydroxycholesterol 7-alpha-hydroxylase
Search

CYP7B1

0.77	25-hydroxycholesterol 7-alpha-hydroxylase

0.59	GO:0035754	B cell chemotaxis
0.59	GO:0006699	bile acid biosynthetic process
0.58	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
0.58	GO:0060740	prostate gland epithelium morphogenesis
0.55	GO:0050679	positive regulation of epithelial cell proliferation
0.53	GO:0055114	oxidation-reduction process
0.40	GO:0008203	cholesterol metabolic process
0.40	GO:0046457	prostanoid biosynthetic process
0.40	GO:0006693	prostaglandin metabolic process
0.39	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway

0.68	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.68	GO:0004497	monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.41	GO:0008116	prostaglandin-I synthase activity
0.32	GO:0005515	protein binding

0.63	GO:0005789	endoplasmic reticulum membrane
0.38	GO:0005901	caveola
0.36	GO:0031090	organelle membrane
0.35	GO:0005615	extracellular space
0.35	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.68	EC:1.14	GO:0016705
0.41	KEGG:R02267	GO:0008116

sp|O75882|ATRN_HUMAN
Attractin
Search

ATRN

0.97

Attractin

0.55	GO:0021549	cerebellum development
0.55	GO:0040014	regulation of multicellular organism growth
0.55	GO:0042552	myelination
0.54	GO:0043473	pigmentation
0.39	GO:0007186	G-protein coupled receptor signaling pathway
0.38	GO:0006954	inflammatory response
0.37	GO:0006979	response to oxidative stress
0.34	GO:0016569	covalent chromatin modification
0.33	GO:0006351	transcription, DNA-templated
0.33	GO:1903506	regulation of nucleic acid-templated transcription

0.46	GO:0004872	receptor activity
0.37	GO:0030246	carbohydrate binding
0.33	GO:0005515	protein binding
0.32	GO:0016787	hydrolase activity

0.51	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.34	GO:0005886	plasma membrane
0.33	GO:0005737	cytoplasm
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.32

GO:0016787

sp|O75884|RBBP9_HUMAN
Putative hydrolase RBBP9
Search

RBBP9

0.37	Retinoblastoma binding protein 9

0.40	GO:0042127	regulation of cell proliferation
0.35	GO:0009312	oligosaccharide biosynthetic process
0.34	GO:0006446	regulation of translational initiation
0.34	GO:0006413	translational initiation
0.32	GO:0006429	leucyl-tRNA aminoacylation
0.32	GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity

0.51	GO:0016787	hydrolase activity
0.35	GO:0005515	protein binding
0.34	GO:0043022	ribosome binding
0.34	GO:0003743	translation initiation factor activity
0.32	GO:0004823	leucine-tRNA ligase activity
0.31	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.50	GO:0005654	nucleoplasm
0.38	GO:0070062	extracellular exosome
0.34	GO:0005852	eukaryotic translation initiation factor 3 complex

0.51	EC:3	GO:0016787
0.32	KEGG:R03657	GO:0004823

sp|O75886|STAM2_HUMAN
Signal transducing adapter molecule 2
Search

STAM2

0.97	Signal transducing adapter molecule 2

0.68	GO:0006886	intracellular protein transport
0.39	GO:1903551	regulation of extracellular exosome assembly
0.39	GO:1903543	positive regulation of exosomal secretion
0.36	GO:0036258	multivesicular body assembly
0.35	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
0.35	GO:0016236	macroautophagy
0.35	GO:0016197	endosomal transport
0.34	GO:0016579	protein deubiquitination
0.34	GO:0061024	membrane organization
0.33	GO:0007165	signal transduction

0.37	GO:0044389	ubiquitin-like protein ligase binding
0.34	GO:0017124	SH3 domain binding

0.48	GO:0005654	nucleoplasm
0.48	GO:0005829	cytosol
0.41	GO:0044440	endosomal part
0.39	GO:0005769	early endosome
0.37	GO:0098805	whole membrane
0.37	GO:0098588	bounding membrane of organelle
0.35	GO:0043234	protein complex
0.34	GO:0030139	endocytic vesicle
0.30	GO:0031224	intrinsic component of membrane

sp|O75888|TNF13_HUMAN
Tumor necrosis factor ligand superfamily member 13
Search

TNFSF13

0.96	Tumor necrosis factor ligand superfamily member 13

0.74	GO:0006955	immune response
0.72	GO:0010469	regulation of receptor activity
0.51	GO:0050871	positive regulation of B cell activation
0.50	GO:0002824	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
0.50	GO:0048296	regulation of isotype switching to IgA isotypes
0.49	GO:0002639	positive regulation of immunoglobulin production
0.49	GO:0045911	positive regulation of DNA recombination
0.48	GO:0002708	positive regulation of lymphocyte mediated immunity
0.47	GO:0051094	positive regulation of developmental process
0.45	GO:0051240	positive regulation of multicellular organismal process

0.83	GO:0005164	tumor necrosis factor receptor binding
0.76	GO:0005125	cytokine activity

0.70	GO:0005615	extracellular space
0.39	GO:0048471	perinuclear region of cytoplasm
0.38	GO:1903561	extracellular vesicle
0.37	GO:0009897	external side of plasma membrane
0.36	GO:0005654	nucleoplasm
0.36	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

sp|O75891|AL1L1_HUMAN
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Search

ALDH1L1

0.92	Mitochondrial 10-formyltetrahydrofolate dehydrogenase

0.85	GO:0009258	10-formyltetrahydrofolate catabolic process
0.70	GO:0006730	one-carbon metabolic process
0.52	GO:0055114	oxidation-reduction process
0.49	GO:0009058	biosynthetic process
0.45	GO:0048885	neuromast deposition
0.44	GO:0048703	embryonic viscerocranium morphogenesis
0.43	GO:0001755	neural crest cell migration
0.42	GO:0007369	gastrulation
0.42	GO:0007507	heart development
0.36	GO:0046655	folic acid metabolic process

0.85	GO:0016155	formyltetrahydrofolate dehydrogenase activity
0.73	GO:0016742	hydroxymethyl-, formyl- and related transferase activity
0.68	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.35	GO:0016787	hydrolase activity
0.34	GO:0005515	protein binding
0.34	GO:0044877	macromolecular complex binding

0.48	GO:0005737	cytoplasm
0.43	GO:0043231	intracellular membrane-bounded organelle
0.37	GO:0070062	extracellular exosome
0.33	GO:0043233	organelle lumen
0.33	GO:0043234	protein complex
0.32	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.85	EC:1.5.1.6	GO:0016155
0.85	KEGG:R00941	GO:0016155

sp|O75896|TUSC2_HUMAN
Tumor suppressor candidate 2
Search

TUSC2

0.97	LOW QUALITY PROTEIN: tumor suppressor candidate 2

0.86	GO:0032618	interleukin-15 production
0.86	GO:0071609	chemokine (C-C motif) ligand 5 production
0.86	GO:0052567	response to defense-related host reactive oxygen species production
0.85	GO:0070945	neutrophil mediated killing of gram-negative bacterium
0.84	GO:0001779	natural killer cell differentiation
0.84	GO:0032700	negative regulation of interleukin-17 production
0.83	GO:0032733	positive regulation of interleukin-10 production
0.80	GO:0051881	regulation of mitochondrial membrane potential
0.78	GO:2000377	regulation of reactive oxygen species metabolic process
0.78	GO:0006909	phagocytosis

0.38	GO:0005515	protein binding
0.38	GO:0004415	hyalurononglucosaminidase activity
0.36	GO:0003700	DNA binding transcription factor activity
0.36	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.33	GO:0046872	metal ion binding

0.57	GO:0005739	mitochondrion
0.37	GO:0005667	transcription factor complex
0.36	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.38

EC:3.2.1.35

GO:0004415

sp|O75897|ST1C4_HUMAN
Sulfotransferase 1C4
Search

0.57	Sulfotransferase

0.52	GO:0051923	sulfation
0.50	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
0.50	GO:0006068	ethanol catabolic process
0.33	GO:0006805	xenobiotic metabolic process
0.33	GO:0009308	amine metabolic process

0.78	GO:0008146	sulfotransferase activity
0.33	GO:0005515	protein binding

0.43	GO:0005829	cytosol
0.34	GO:0070062	extracellular exosome

0.78

EC:2.8.2

GO:0008146

sp|O75899|GABR2_HUMAN
Gamma-aminobutyric acid type B receptor subunit 2
Search

GABBR2

0.92	LOW QUALITY PROTEIN: gamma-aminobutyric acid type B receptor subunit 2

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.36	GO:0007194	negative regulation of adenylate cyclase activity
0.35	GO:0007268	chemical synaptic transmission

0.84	GO:0004965	G-protein coupled GABA receptor activity
0.52	GO:0046982	protein heterodimerization activity

0.62	GO:0038039	G-protein coupled receptor heterodimeric complex
0.60	GO:1902710	GABA receptor complex
0.53	GO:0043005	neuron projection
0.39	GO:0045211	postsynaptic membrane
0.39	GO:0005737	cytoplasm
0.38	GO:0030054	cell junction
0.36	GO:0043204	perikaryon
0.35	GO:0120038	plasma membrane bounded cell projection part

sp|O75900|MMP23_HUMAN
Matrix metalloproteinase-23
Search

MMP23B

0.97	Matrix metalloproteinase-23

0.61	GO:0006508	proteolysis
0.47	GO:0000003	reproduction
0.40	GO:0001889	liver development
0.36	GO:0016567	protein ubiquitination
0.34	GO:0006886	intracellular protein transport
0.33	GO:0016192	vesicle-mediated transport
0.32	GO:0034769	basement membrane disassembly

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.36	GO:0004842	ubiquitin-protein transferase activity
0.35	GO:0016874	ligase activity
0.32	GO:0016887	ATPase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.74	GO:0031012	extracellular matrix
0.38	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0030131	clathrin adaptor complex
0.32	GO:0009986	cell surface
0.30	GO:0016021	integral component of membrane

0.70	EC:3.4.24	GO:0004222
0.36	KEGG:R03876	GO:0004842

sp|O75901|RASF9_HUMAN
Ras association domain-containing protein 9
Search

RASSF9

0.97	Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor

0.75	GO:0016197	endosomal transport
0.60	GO:0007165	signal transduction
0.36	GO:0006605	protein targeting
0.34	GO:0055114	oxidation-reduction process

0.37	GO:0004497	monooxygenase activity
0.36	GO:0005515	protein binding
0.34	GO:0005215	transporter activity

0.57	GO:0012510	trans-Golgi network transport vesicle membrane
0.53	GO:0005768	endosome
0.50	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.33	GO:0000922	spindle pole
0.33	GO:0005815	microtubule organizing center

sp|O75907|DGAT1_HUMAN
Diacylglycerol O-acyltransferase 1
Search

DGAT1

0.61	Diacylglycerol O-acyltransferase 1

0.80	GO:0019432	triglyceride biosynthetic process
0.56	GO:0034379	very-low-density lipoprotein particle assembly
0.55	GO:0055089	fatty acid homeostasis
0.55	GO:0046339	diacylglycerol metabolic process
0.54	GO:0035336	long-chain fatty-acyl-CoA metabolic process
0.52	GO:0019915	lipid storage
0.44	GO:0001878	response to yeast
0.41	GO:0042572	retinol metabolic process
0.36	GO:0036155	acylglycerol acyl-chain remodeling
0.36	GO:1901738	regulation of vitamin A metabolic process

0.79	GO:0004144	diacylglycerol O-acyltransferase activity
0.56	GO:0003846	2-acylglycerol O-acyltransferase activity
0.44	GO:0050252	retinol O-fatty-acyltransferase activity
0.35	GO:0005504	fatty acid binding
0.35	GO:0019992	diacylglycerol binding
0.33	GO:0005515	protein binding
0.32	GO:0004672	protein kinase activity
0.31	GO:0005524	ATP binding

0.65	GO:0005789	endoplasmic reticulum membrane
0.36	GO:0035579	specific granule membrane
0.34	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.79

EC:2.3.1.20

GO:0004144

sp|O75908|SOAT2_HUMAN
Sterol O-acyltransferase 2
Search

SOAT2

0.62	O-acyltransferase

0.77	GO:0034435	cholesterol esterification
0.70	GO:0042632	cholesterol homeostasis
0.65	GO:0034379	very-low-density lipoprotein particle assembly
0.63	GO:0008203	cholesterol metabolic process
0.63	GO:0033344	cholesterol efflux
0.52	GO:0042986	positive regulation of amyloid precursor protein biosynthetic process
0.52	GO:0010742	macrophage derived foam cell differentiation
0.51	GO:0010878	cholesterol storage
0.37	GO:0034383	low-density lipoprotein particle clearance
0.36	GO:0030299	intestinal cholesterol absorption

0.78	GO:0034736	cholesterol O-acyltransferase activity
0.60	GO:0015485	cholesterol binding
0.59	GO:0000062	fatty-acyl-CoA binding
0.33	GO:0005515	protein binding
0.32	GO:0003676	nucleic acid binding

0.67	GO:0005789	endoplasmic reticulum membrane
0.55	GO:0005903	brush border
0.30	GO:0016021	integral component of membrane

0.78	EC:2.3.1.26	GO:0034736
0.78	KEGG:R01461	GO:0034736

sp|O75909|CCNK_HUMAN
Cyclin-K
Search

CCNK

0.91

Cyclin K

0.57	GO:1901409	positive regulation of phosphorylation of RNA polymerase II C-terminal domain
0.56	GO:0044828	negative regulation by host of viral genome replication
0.55	GO:2001163	regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
0.54	GO:0071157	negative regulation of cell cycle arrest
0.48	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
0.45	GO:0045944	positive regulation of transcription by RNA polymerase II
0.44	GO:0006974	cellular response to DNA damage stimulus
0.44	GO:0006468	protein phosphorylation
0.36	GO:2000737	negative regulation of stem cell differentiation
0.36	GO:0042795	snRNA transcription by RNA polymerase II

0.53	GO:0004693	cyclin-dependent protein serine/threonine kinase activity
0.53	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.50	GO:0019901	protein kinase binding
0.47	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity

0.60	GO:0005634	nucleus
0.57	GO:0002944	cyclin K-CDK12 complex
0.57	GO:0002945	cyclin K-CDK13 complex
0.47	GO:0031974	membrane-enclosed lumen
0.42	GO:0044446	intracellular organelle part
0.33	GO:0032993	protein-DNA complex
0.33	GO:0005694	chromosome
0.30	GO:0016020	membrane

0.53

EC:2.7.11.22

GO:0004693

sp|O75911|DHRS3_HUMAN
Short-chain dehydrogenase/reductase 3
Search

DHRS3

0.97	Short-chain dehydrogenase/reductase 3

0.84	GO:0042572	retinol metabolic process
0.58	GO:0048387	negative regulation of retinoic acid receptor signaling pathway
0.56	GO:0060411	cardiac septum morphogenesis
0.55	GO:0003151	outflow tract morphogenesis
0.55	GO:0060021	palate development
0.55	GO:0060349	bone morphogenesis
0.54	GO:0030278	regulation of ossification
0.52	GO:0055114	oxidation-reduction process
0.42	GO:0002138	retinoic acid biosynthetic process
0.36	GO:0007601	visual perception

0.85	GO:0004745	retinol dehydrogenase activity
0.46	GO:0052650	NADP-retinol dehydrogenase activity
0.33	GO:0102131	3-oxo-glutaryl-[acp] methyl ester reductase activity
0.33	GO:0102132	3-oxo-pimeloyl-[acp] methyl ester reductase activity
0.33	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
0.33	GO:0009055	electron transfer activity
0.33	GO:0003885	D-arabinono-1,4-lactone oxidase activity
0.33	GO:1901265	nucleoside phosphate binding
0.32	GO:0036094	small molecule binding
0.32	GO:0008874	gluconate 5-dehydrogenase activity

0.35	GO:0042622	photoreceptor outer segment membrane
0.34	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.85	EC:1.1.1.105	GO:0004745
0.46	KEGG:R08379	GO:0052650

sp|O75912|DGKI_HUMAN
Diacylglycerol kinase iota
Search

DGKI

0.48	Diacylglycerol kinase iota

0.83	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
0.61	GO:0035556	intracellular signal transduction
0.59	GO:1900452	regulation of long term synaptic depression
0.59	GO:0046959	habituation
0.57	GO:0034260	negative regulation of GTPase activity
0.57	GO:0016310	phosphorylation
0.57	GO:0051966	regulation of synaptic transmission, glutamatergic
0.56	GO:0046579	positive regulation of Ras protein signal transduction
0.55	GO:0099643	signal release from synapse
0.55	GO:0099531	presynaptic process involved in chemical synaptic transmission

0.80	GO:0004143	diacylglycerol kinase activity
0.76	GO:0003951	NAD+ kinase activity
0.59	GO:0005095	GTPase inhibitor activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0017016	Ras GTPase binding
0.33	GO:0046872	metal ion binding

0.57	GO:0032045	guanyl-nucleotide exchange factor complex
0.56	GO:0043197	dendritic spine
0.53	GO:0048471	perinuclear region of cytoplasm
0.53	GO:0098793	presynapse
0.50	GO:0005654	nucleoplasm
0.44	GO:0060076	excitatory synapse
0.43	GO:0044306	neuron projection terminus
0.42	GO:0014069	postsynaptic density
0.42	GO:0070382	exocytic vesicle
0.42	GO:0043025	neuronal cell body

0.80	EC:2.7.1.107	GO:0004143
0.76	KEGG:R00104	GO:0003951

sp|O75914|PAK3_HUMAN
Serine/threonine-protein kinase PAK 3
Search

PAK3

0.94	LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 3

0.73	GO:0042981	regulation of apoptotic process
0.63	GO:0006468	protein phosphorylation
0.55	GO:0060997	dendritic spine morphogenesis
0.53	GO:0000187	activation of MAPK activity
0.51	GO:0007409	axonogenesis
0.50	GO:0030833	regulation of actin filament polymerization
0.49	GO:0071407	cellular response to organic cyclic compound
0.47	GO:0031098	stress-activated protein kinase signaling cascade
0.47	GO:0007266	Rho protein signal transduction
0.46	GO:0050770	regulation of axonogenesis

0.70	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.55	GO:0004708	MAP kinase kinase activity
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0017048	Rho GTPase binding
0.39	GO:0017124	SH3 domain binding
0.37	GO:0042803	protein homodimerization activity
0.35	GO:0046872	metal ion binding

0.37	GO:0005622	intracellular
0.36	GO:0031982	vesicle
0.36	GO:0012505	endomembrane system
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044422	organelle part
0.33	GO:1902494	catalytic complex
0.33	GO:0043228	non-membrane-bounded organelle
0.33	GO:0005886	plasma membrane
0.32	GO:0098796	membrane protein complex

0.70

GO:0004674

sp|O75915|PRAF3_HUMAN
PRA1 family protein 3
Search

sp|O75916|RGS9_HUMAN
Regulator of G-protein signaling 9
Search

RGS9

0.93	Regulator of G-protein signaling 9

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.61	GO:0035556	intracellular signal transduction
0.46	GO:0043547	positive regulation of GTPase activity
0.40	GO:0007601	visual perception
0.40	GO:0043627	response to estrogen
0.40	GO:0009968	negative regulation of signal transduction
0.40	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.38	GO:0007399	nervous system development
0.34	GO:0006457	protein folding

0.63	GO:0004871	signal transducer activity
0.46	GO:0005096	GTPase activator activity
0.38	GO:0032403	protein complex binding
0.36	GO:0031681	G-protein beta-subunit binding

0.80	GO:1905360	GTPase complex
0.79	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.65	GO:0098797	plasma membrane protein complex
0.59	GO:0001917	photoreceptor inner segment
0.58	GO:0001750	photoreceptor outer segment
0.38	GO:0060170	ciliary membrane
0.37	GO:0005737	cytoplasm
0.36	GO:0005634	nucleus
0.34	GO:0044292	dendrite terminus
0.30	GO:0031224	intrinsic component of membrane

sp|O75920|SERF1_HUMAN
Small EDRK-rich factor 1
Search

SERF1A

0.77	Small EDRK-rich factor 1

0.45

GO:0007399

nervous system development

0.43	GO:0005829	cytosol
0.41	GO:0005634	nucleus
0.30	GO:0044425	membrane part

sp|O75923|DYSF_HUMAN
Dysferlin
Search

DYSF

0.91

Dysferlin

0.60	GO:0001778	plasma membrane repair
0.56	GO:0006906	vesicle fusion
0.37	GO:0071433	cell wall repair
0.37	GO:0033292	T-tubule organization
0.37	GO:0006936	muscle contraction
0.36	GO:0048644	muscle organ morphogenesis

0.55	GO:0005544	calcium-dependent phospholipid binding
0.50	GO:0005509	calcium ion binding
0.36	GO:0005515	protein binding

0.59	GO:0030315	T-tubule
0.55	GO:0030027	lamellipodium
0.55	GO:0030139	endocytic vesicle
0.54	GO:0005770	late endosome
0.54	GO:0005769	early endosome
0.51	GO:0005815	microtubule organizing center
0.40	GO:0030659	cytoplasmic vesicle membrane
0.39	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

sp|O75925|PIAS1_HUMAN
E3 SUMO-protein ligase PIAS1
Search

PIAS1

0.96	Protein inhibitor of activated STAT 1 (Predicted)

0.65	GO:0033235	positive regulation of protein sumoylation
0.61	GO:0045444	fat cell differentiation
0.61	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.59	GO:0016925	protein sumoylation
0.57	GO:0000122	negative regulation of transcription by RNA polymerase II
0.56	GO:0042127	regulation of cell proliferation
0.42	GO:0051152	positive regulation of smooth muscle cell differentiation
0.41	GO:0008542	visual learning
0.41	GO:0000082	G1/S transition of mitotic cell cycle
0.40	GO:0007283	spermatogenesis

0.65	GO:0061665	SUMO ligase activity
0.63	GO:0008270	zinc ion binding
0.58	GO:0031625	ubiquitin protein ligase binding
0.54	GO:0008134	transcription factor binding
0.41	GO:0008022	protein C-terminus binding
0.39	GO:0019904	protein domain specific binding

0.61	GO:0016605	PML body
0.30	GO:0016020	membrane

sp|O75928|PIAS2_HUMAN
E3 SUMO-protein ligase PIAS2
Search

PIAS2

0.90	Protein inhibitor of activated STAT 2

0.81	GO:0016925	protein sumoylation
0.64	GO:0060766	negative regulation of androgen receptor signaling pathway
0.62	GO:0045667	regulation of osteoblast differentiation
0.56	GO:0045944	positive regulation of transcription by RNA polymerase II
0.46	GO:0006351	transcription, DNA-templated

0.83	GO:0019789	SUMO transferase activity
0.63	GO:0008270	zinc ion binding
0.59	GO:0031625	ubiquitin protein ligase binding
0.56	GO:0061659	ubiquitin-like protein ligase activity
0.55	GO:0008134	transcription factor binding
0.45	GO:0003677	DNA binding

0.61	GO:0016605	PML body
0.30	GO:0031224	intrinsic component of membrane

sp|O75934|SPF27_HUMAN
Pre-mRNA-splicing factor SPF27
Search

BCAS2

0.93	BCAS2, pre-mRNA processing factor

0.70

GO:0006397

mRNA processing

0.72	GO:0005662	DNA replication factor A complex
0.72	GO:0071007	U2-type catalytic step 2 spliceosome
0.67	GO:0016607	nuclear speck
0.66	GO:0005813	centrosome
0.57	GO:0071011	precatalytic spliceosome
0.57	GO:0000974	Prp19 complex

sp|O75935|DCTN3_HUMAN
Dynactin subunit 3
Search

DCTN3

0.97	Dynactin complex subunit 22 kDa subunit

0.76	GO:0061640	cytoskeleton-dependent cytokinesis
0.67	GO:0007017	microtubule-based process
0.42	GO:0097711	ciliary basal body-plasma membrane docking
0.41	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.41	GO:0000086	G2/M transition of mitotic cell cycle
0.40	GO:0010389	regulation of G2/M transition of mitotic cell cycle
0.39	GO:0006888	ER to Golgi vesicle-mediated transport

0.38	GO:0003676	nucleic acid binding
0.36	GO:0005515	protein binding
0.36	GO:0005198	structural molecule activity

0.77	GO:0005869	dynactin complex
0.74	GO:0048471	perinuclear region of cytoplasm
0.73	GO:0005813	centrosome
0.70	GO:0005730	nucleolus
0.65	GO:0005829	cytosol
0.48	GO:0097610	cell surface furrow
0.47	GO:0030496	midbody
0.46	GO:0032155	cell division site part
0.46	GO:0000777	condensed chromosome kinetochore
0.45	GO:0005819	spindle

sp|O75936|BODG_HUMAN
Gamma-butyrobetaine dioxygenase
Search

BBOX1

0.74	Gamma-butyrobetaine dioxygenase

0.81	GO:0045329	carnitine biosynthetic process
0.52	GO:0055114	oxidation-reduction process

0.83	GO:0008336	gamma-butyrobetaine dioxygenase activity
0.59	GO:0005506	iron ion binding
0.52	GO:0042802	identical protein binding
0.47	GO:0008270	zinc ion binding
0.33	GO:0050353	trimethyllysine dioxygenase activity

0.45	GO:0005739	mitochondrion
0.37	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol

0.83	EC:1.14.11.1	GO:0008336
0.83	KEGG:R02397	GO:0008336

sp|O75937|DNJC8_HUMAN
DnaJ homolog subfamily C member 8
Search

DNAJC8

0.92	DnaJ like protein subfamily C member 8

0.43

GO:0000398

mRNA splicing, via spliceosome

0.85

GO:0030544

Hsp70 protein binding

0.84	GO:0045171	intercellular bridge
0.68	GO:0005654	nucleoplasm
0.67	GO:0005829	cytosol

sp|O75940|SPF30_HUMAN
Survival of motor neuron-related-splicing factor 30
Search

SMNDC1

0.94	Survival motor neuron domain-containing protein 1

0.67	GO:0006397	mRNA processing
0.40	GO:0008380	RNA splicing
0.39	GO:0006915	apoptotic process

0.57	GO:0003723	RNA binding
0.33	GO:0005515	protein binding

0.59	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.38	GO:0070013	intracellular organelle lumen
0.37	GO:1990904	ribonucleoprotein complex
0.36	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

sp|O75943|RAD17_HUMAN
Cell cycle checkpoint protein RAD17
Search

RAD17

0.88	RAD17 checkpoint clamp loader component

0.76	GO:0000077	DNA damage checkpoint
0.66	GO:0007049	cell cycle
0.64	GO:0006281	DNA repair
0.57	GO:0045930	negative regulation of mitotic cell cycle
0.57	GO:0008156	negative regulation of DNA replication
0.52	GO:0042325	regulation of phosphorylation
0.48	GO:0000076	DNA replication checkpoint
0.48	GO:1902750	negative regulation of cell cycle G2/M phase transition
0.47	GO:0010389	regulation of G2/M transition of mitotic cell cycle
0.36	GO:1901796	regulation of signal transduction by p53 class mediator

0.80	GO:0003689	DNA clamp loader activity
0.46	GO:0003682	chromatin binding
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding

0.82	GO:0031389	Rad17 RFC-like complex
0.61	GO:0005634	nucleus
0.56	GO:0000781	chromosome, telomeric region
0.50	GO:0031974	membrane-enclosed lumen
0.44	GO:0000785	chromatin
0.30	GO:0016020	membrane

sp|O75947|ATP5H_HUMAN
ATP synthase subunit d, mitochondrial
Search

ATP5H

0.73	ATP synthase subunit d, mitochondrial

0.68	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.68	GO:0006754	ATP biosynthetic process
0.49	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.35	GO:0042407	cristae formation
0.34	GO:0006839	mitochondrial transport
0.34	GO:0046907	intracellular transport

0.61	GO:0015078	hydrogen ion transmembrane transporter activity
0.50	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
0.49	GO:0019829	cation-transporting ATPase activity

0.75	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
0.58	GO:0045265	proton-transporting ATP synthase, stator stalk
0.47	GO:0043209	myelin sheath
0.44	GO:0005654	nucleoplasm
0.36	GO:0070062	extracellular exosome

sp|O75949|F155B_HUMAN
Transmembrane protein FAM155B
Search

FAM155B

0.92	Transmembrane protein FAM155B

0.55	GO:0098703	calcium ion import across plasma membrane
0.40	GO:0006275	regulation of DNA replication
0.37	GO:0006259	DNA metabolic process

0.56	GO:0015275	stretch-activated, cation-selective, calcium channel activity
0.42	GO:0030337	DNA polymerase processivity factor activity
0.36	GO:0003677	DNA binding

0.41	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O75951|LYZL6_HUMAN
Lysozyme-like protein 6
Search

0.67	Lysozyme-like protein 6

0.74	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization
0.69	GO:0050830	defense response to Gram-positive bacterium
0.68	GO:0050829	defense response to Gram-negative bacterium
0.64	GO:0019835	cytolysis
0.63	GO:0016998	cell wall macromolecule catabolic process

0.76

GO:0003796

lysozyme activity

0.77	GO:0097524	sperm plasma membrane
0.75	GO:0097225	sperm midpiece
0.62	GO:0009986	cell surface
0.60	GO:0005615	extracellular space

0.76

EC:3.2.1.17

GO:0003796

sp|O75952|CABYR_HUMAN
Calcium-binding tyrosine phosphorylation-regulated protein
Search

CABYR

0.90	Calcium binding tyrosine phosphorylation regulated

0.72	GO:0019904	protein domain specific binding
0.70	GO:0046982	protein heterodimerization activity
0.68	GO:0005509	calcium ion binding

0.86	GO:0097229	sperm end piece
0.86	GO:0035686	sperm fibrous sheath
0.82	GO:0097228	sperm principal piece
0.69	GO:0005829	cytosol
0.61	GO:0005634	nucleus

sp|O75953|DNJB5_HUMAN
DnaJ homolog subfamily B member 5
Search

DNAJB5

0.97	DnaJ like protein subfamily B member 5

0.68	GO:0006457	protein folding
0.53	GO:0000122	negative regulation of transcription by RNA polymerase II
0.53	GO:0006986	response to unfolded protein
0.42	GO:0090084	negative regulation of inclusion body assembly
0.41	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress
0.41	GO:0032781	positive regulation of ATPase activity
0.36	GO:0002088	lens development in camera-type eye

0.70	GO:0051082	unfolded protein binding
0.52	GO:0051087	chaperone binding
0.42	GO:0001106	RNA polymerase II transcription corepressor activity
0.41	GO:0030544	Hsp70 protein binding
0.41	GO:0051117	ATPase binding
0.41	GO:0001671	ATPase activator activity
0.40	GO:0045296	cadherin binding
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding

0.48	GO:0005829	cytosol
0.45	GO:0005634	nucleus
0.34	GO:0014069	postsynaptic density
0.34	GO:0070062	extracellular exosome
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.32	GO:0044446	intracellular organelle part

sp|O75954|TSN9_HUMAN
Tetraspanin-9
Search

TSPAN9

0.58	Tetraspanin

0.44	GO:0007166	cell surface receptor signaling pathway
0.33	GO:2001141	regulation of RNA biosynthetic process
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.33

GO:0003700

DNA binding transcription factor activity

0.56	GO:0097197	tetraspanin-enriched microdomain
0.42	GO:0005887	integral component of plasma membrane
0.37	GO:0005925	focal adhesion

sp|O75955|FLOT1_HUMAN
Flotillin-1
Search

FLOT1

0.90	Novel flotillin

0.85	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin
0.85	GO:0060355	positive regulation of cell adhesion molecule production
0.84	GO:0032226	positive regulation of synaptic transmission, dopaminergic
0.84	GO:0070528	protein kinase C signaling
0.83	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway
0.83	GO:1903044	protein localization to membrane raft
0.83	GO:1901741	positive regulation of myoblast fusion
0.83	GO:0034116	positive regulation of heterotypic cell-cell adhesion
0.82	GO:0071360	cellular response to exogenous dsRNA
0.82	GO:0048643	positive regulation of skeletal muscle tissue development

0.78	GO:0002020	protease binding
0.68	GO:0046982	protein heterodimerization activity
0.52	GO:0035255	ionotropic glutamate receptor binding

0.83	GO:0016600	flotillin complex
0.82	GO:0001931	uropod
0.80	GO:0034451	centriolar satellite
0.78	GO:0044291	cell-cell contact zone
0.77	GO:0042383	sarcolemma
0.76	GO:0005913	cell-cell adherens junction
0.76	GO:0030027	lamellipodium
0.75	GO:0016323	basolateral plasma membrane
0.74	GO:0008180	COP9 signalosome
0.74	GO:0030864	cortical actin cytoskeleton

sp|O75956|CDKA2_HUMAN
Cyclin-dependent kinase 2-associated protein 2
Search

CDK2AP2

0.94	Cyclin-dependent kinase 2-associated protein 2

0.57	GO:2000035	regulation of stem cell division
0.57	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle
0.53	GO:0070507	regulation of microtubule cytoskeleton organization
0.50	GO:0016310	phosphorylation
0.46	GO:0001934	positive regulation of protein phosphorylation
0.38	GO:0015914	phospholipid transport
0.36	GO:0060325	face morphogenesis
0.36	GO:0001701	in utero embryonic development
0.35	GO:0007049	cell cycle
0.34	GO:1903506	regulation of nucleic acid-templated transcription

0.52	GO:0016301	kinase activity
0.50	GO:0070182	DNA polymerase binding
0.39	GO:0005548	phospholipid transporter activity
0.37	GO:0005509	calcium ion binding
0.36	GO:0031210	phosphatidylcholine binding
0.36	GO:0070300	phosphatidic acid binding
0.35	GO:0030971	receptor tyrosine kinase binding
0.35	GO:0035091	phosphatidylinositol binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.49	GO:0005874	microtubule
0.48	GO:0005634	nucleus
0.47	GO:0048471	perinuclear region of cytoplasm
0.44	GO:0005829	cytosol
0.43	GO:0031974	membrane-enclosed lumen
0.35	GO:0036464	cytoplasmic ribonucleoprotein granule
0.34	GO:0005815	microtubule organizing center

sp|O75962|TRIO_HUMAN
Triple functional domain protein
Search

TRIO

0.90	Trio Rho guanine nucleotide exchange factor a

0.78	GO:0035023	regulation of Rho protein signal transduction
0.66	GO:0065009	regulation of molecular function
0.65	GO:0045599	negative regulation of fat cell differentiation
0.63	GO:0006468	protein phosphorylation
0.34	GO:0018210	peptidyl-threonine modification
0.34	GO:0018209	peptidyl-serine modification
0.33	GO:0042981	regulation of apoptotic process
0.33	GO:0035556	intracellular signal transduction

0.78	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.70	GO:0004674	protein serine/threonine kinase activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding

0.32

GO:0005622

intracellular

0.70

GO:0004674

sp|O75964|ATP5L_HUMAN
ATP synthase subunit g, mitochondrial
Search

ATP5L

0.92	ATP synthase subunit gserine-threonine

0.70	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.70	GO:0006754	ATP biosynthetic process
0.45	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.36	GO:0051568	histone H3-K4 methylation
0.35	GO:0042407	cristae formation
0.34	GO:0006839	mitochondrial transport
0.34	GO:0006511	ubiquitin-dependent protein catabolic process
0.34	GO:0046907	intracellular transport
0.34	GO:0016567	protein ubiquitination
0.33	GO:0006355	regulation of transcription, DNA-templated

0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.46	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
0.46	GO:0019829	cation-transporting ATPase activity
0.36	GO:0042800	histone methyltransferase activity (H3-K4 specific)
0.36	GO:0047624	adenosine-tetraphosphatase activity
0.35	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
0.35	GO:0034450	ubiquitin-ubiquitin ligase activity
0.34	GO:0008270	zinc ion binding
0.33	GO:0003677	DNA binding

0.78	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
0.36	GO:0070062	extracellular exosome
0.36	GO:0071339	MLL1 complex
0.34	GO:0000151	ubiquitin ligase complex
0.32	GO:0030126	COPI vesicle coat
0.32	GO:0005783	endoplasmic reticulum
0.30	GO:0016021	integral component of membrane

0.36

EC:3.6.1.14

GO:0047624

sp|O75969|AKAP3_HUMAN
A-kinase anchor protein 3
Search

AKAP3

0.97	A-kinase anchoring protein 3

0.68	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.60	GO:0010738	regulation of protein kinase A signaling
0.57	GO:0008104	protein localization
0.48	GO:0016310	phosphorylation
0.42	GO:0044458	motile cilium assembly
0.42	GO:0030317	flagellated sperm motility
0.40	GO:0007340	acrosome reaction
0.35	GO:0051234	establishment of localization

0.74	GO:0051018	protein kinase A binding
0.49	GO:0016301	kinase activity
0.36	GO:0003924	GTPase activity
0.36	GO:0032550	purine ribonucleoside binding
0.36	GO:0019001	guanyl nucleotide binding
0.34	GO:0032555	purine ribonucleotide binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.80	GO:0035686	sperm fibrous sheath
0.77	GO:0097228	sperm principal piece
0.71	GO:0001669	acrosomal vesicle
0.41	GO:0030018	Z disc
0.40	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0005634	nucleus
0.33	GO:0005952	cAMP-dependent protein kinase complex
0.32	GO:0005856	cytoskeleton

sp|O75970|MPDZ_HUMAN
Multiple PDZ domain protein
Search

MPDZ

0.85	Multiple PDZ domain crumbs cell polarity complex component

0.71	GO:0007155	cell adhesion
0.42	GO:0042552	myelination
0.38	GO:0016032	viral process
0.37	GO:0035556	intracellular signal transduction

0.83

GO:0008022

protein C-terminus binding

0.86	GO:0043220	Schmidt-Lanterman incisure
0.86	GO:0016327	apicolateral plasma membrane
0.80	GO:0016324	apical plasma membrane
0.79	GO:0005923	bicellular tight junction
0.71	GO:0031410	cytoplasmic vesicle
0.51	GO:0014069	postsynaptic density
0.50	GO:0030425	dendrite
0.49	GO:0045211	postsynaptic membrane
0.38	GO:0012505	endomembrane system
0.30	GO:0031224	intrinsic component of membrane

sp|O75971|SNPC5_HUMAN
snRNA-activating protein complex subunit 5
Search

SNAPC5

0.97	Small nuclear RNA activating complex polypeptide 5

0.85	GO:0006384	transcription initiation from RNA polymerase III promoter
0.75	GO:0006366	transcription by RNA polymerase II
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.37	GO:0009301	snRNA transcription
0.33	GO:0043043	peptide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process

0.61	GO:0003700	DNA binding transcription factor activity
0.34	GO:0005515	protein binding
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0003676	nucleic acid binding

0.61	GO:0005634	nucleus
0.52	GO:0031974	membrane-enclosed lumen
0.47	GO:0043232	intracellular non-membrane-bounded organelle
0.46	GO:0044446	intracellular organelle part
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0044444	cytoplasmic part

sp|O75973|C1QRF_HUMAN
C1q-related factor
Search

0.94	Phospholipase C delta 3

0.55	GO:0061743	motor learning
0.54	GO:0099558	maintenance of synapse structure
0.53	GO:0016322	neuron remodeling
0.44	GO:0050807	regulation of synapse organization
0.40	GO:0051259	protein oligomerization
0.35	GO:0007626	locomotory behavior

0.47

GO:0005515

protein binding

0.73	GO:0005581	collagen trimer
0.63	GO:0005576	extracellular region
0.55	GO:0044301	climbing fiber
0.49	GO:0098793	presynapse
0.37	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O75976|CBPD_HUMAN
Carboxypeptidase D
Search

CPDA

0.63	carboxypeptidase D

0.61	GO:0006508	proteolysis
0.40	GO:0051604	protein maturation
0.37	GO:0006518	peptide metabolic process

0.78	GO:0004181	metallocarboxypeptidase activity
0.72	GO:0004185	serine-type carboxypeptidase activity
0.63	GO:0008270	zinc ion binding

0.40	GO:0005615	extracellular space
0.30	GO:0031224	intrinsic component of membrane
0.30	GO:1903561	extracellular vesicle
0.30	GO:0044464	cell part

0.78

EC:3.4.17

GO:0004181

sp|O75995|SASH3_HUMAN
SAM and SH3 domain-containing protein 3
Search

SASH3

0.97	SAM and SH3 domain-containing protein 3

0.85	GO:0002726	positive regulation of T cell cytokine production
0.84	GO:0032753	positive regulation of interleukin-4 production
0.84	GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation
0.84	GO:0050864	regulation of B cell activation
0.84	GO:0032733	positive regulation of interleukin-10 production
0.83	GO:0032743	positive regulation of interleukin-2 production
0.83	GO:0048873	homeostasis of number of cells within a tissue
0.83	GO:0002639	positive regulation of immunoglobulin production
0.82	GO:0032760	positive regulation of tumor necrosis factor production
0.82	GO:0046622	positive regulation of organ growth

0.53	GO:0001784	phosphotyrosine residue binding
0.36	GO:0031435	mitogen-activated protein kinase kinase kinase binding
0.36	GO:0008022	protein C-terminus binding
0.35	GO:0032947	protein complex scaffold activity
0.33	GO:0003723	RNA binding

0.61	GO:0005634	nucleus
0.49	GO:0005737	cytoplasm
0.41	GO:0005886	plasma membrane
0.33	GO:0043234	protein complex

sp|O76000|OR2B3_HUMAN
Putative olfactory receptor 2B3
Search

0.45	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0010469	regulation of receptor activity

0.76	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity
0.34	GO:0046982	protein heterodimerization activity
0.34	GO:0005179	hormone activity
0.32	GO:0003677	DNA binding

0.55	GO:0005886	plasma membrane
0.34	GO:0000786	nucleosome
0.33	GO:0005938	cell cortex
0.33	GO:0005576	extracellular region
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|O76001|OR2J3_HUMAN
Olfactory receptor 2J3
Search

0.45	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0010469	regulation of receptor activity

0.76	GO:0004984	olfactory receptor activity
0.72	GO:0004930	G-protein coupled receptor activity
0.34	GO:0005179	hormone activity

0.55	GO:0005886	plasma membrane
0.33	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

sp|O76002|OR2J2_HUMAN
Olfactory receptor 2J2
Search

0.45	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.34	GO:0007618	mating
0.33	GO:0006952	defense response

0.76	GO:0004984	olfactory receptor activity
0.72	GO:0004930	G-protein coupled receptor activity

0.56	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O76003|GLRX3_HUMAN
Glutaredoxin-3
Search

GLRX3

0.45	Glutaredoxin-3

0.69	GO:0045454	cell redox homeostasis
0.64	GO:0010614	negative regulation of cardiac muscle hypertrophy
0.63	GO:0002026	regulation of the force of heart contraction
0.61	GO:0022900	electron transport chain
0.54	GO:0044571	[2Fe-2S] cluster assembly
0.52	GO:0097428	protein maturation by iron-sulfur cluster transfer

0.72	GO:0015035	protein disulfide oxidoreductase activity
0.62	GO:0009055	electron transfer activity
0.50	GO:0042802	identical protein binding
0.45	GO:0051536	iron-sulfur cluster binding
0.40	GO:0046872	metal ion binding
0.37	GO:0016853	isomerase activity
0.30	GO:1901363	heterocyclic compound binding
0.30	GO:0019900	kinase binding
0.30	GO:0097159	organic cyclic compound binding

0.60	GO:0030018	Z disc
0.45	GO:0005938	cell cortex
0.43	GO:0005829	cytosol
0.30	GO:0120038	plasma membrane bounded cell projection part
0.30	GO:0005615	extracellular space
0.30	GO:0097447	dendritic tree
0.30	GO:0043230	extracellular organelle
0.30	GO:0031982	vesicle
0.30	GO:0043231	intracellular membrane-bounded organelle

0.37

EC:5

GO:0016853

sp|O76009|KT33A_HUMAN
Keratin, type I cuticular Ha3-I
Search

0.96	Keratin, type I cuticular Ha3-II

0.43	GO:0042633	hair cycle
0.41	GO:0007568	aging
0.40	GO:0070268	cornification
0.38	GO:0045616	regulation of keratinocyte differentiation
0.34	GO:0007010	cytoskeleton organization

0.62	GO:0005198	structural molecule activity
0.35	GO:0005515	protein binding

0.79	GO:0005882	intermediate filament
0.40	GO:0070062	extracellular exosome
0.37	GO:0005829	cytosol

sp|O76011|KRT34_HUMAN
Keratin, type I cuticular Ha4
Search

0.96	LOW QUALITY PROTEIN: keratin, type I cuticular Ha4

0.42	GO:0042633	hair cycle
0.41	GO:0007568	aging
0.40	GO:0070268	cornification
0.38	GO:0045616	regulation of keratinocyte differentiation
0.33	GO:0007010	cytoskeleton organization
0.33	GO:0009653	anatomical structure morphogenesis

0.62	GO:0005198	structural molecule activity
0.35	GO:0005515	protein binding

0.79	GO:0005882	intermediate filament
0.40	GO:0070062	extracellular exosome
0.37	GO:0005829	cytosol

sp|O76013|KRT36_HUMAN
Keratin, type I cuticular Ha6
Search

0.97	Keratin, type I cuticular Ha6

0.54	GO:0045616	regulation of keratinocyte differentiation
0.40	GO:0070268	cornification
0.40	GO:0042633	hair cycle
0.39	GO:0007568	aging
0.33	GO:0009653	anatomical structure morphogenesis
0.33	GO:0007010	cytoskeleton organization

0.62	GO:0005198	structural molecule activity
0.34	GO:0005515	protein binding

0.79	GO:0005882	intermediate filament
0.41	GO:0070062	extracellular exosome
0.37	GO:0005829	cytosol

sp|O76014|KRT37_HUMAN
Keratin, type I cuticular Ha7
Search

0.93	Hair acidic keratin 1

0.41	GO:0045616	regulation of keratinocyte differentiation
0.40	GO:0070268	cornification
0.33	GO:0009653	anatomical structure morphogenesis

0.62	GO:0005198	structural molecule activity
0.34	GO:0005515	protein binding

0.79	GO:0005882	intermediate filament
0.41	GO:0070062	extracellular exosome
0.37	GO:0005829	cytosol

sp|O76015|KRT38_HUMAN
Keratin, type I cuticular Ha8
Search

0.92	Hair acidic keratin 1

0.44	GO:0045616	regulation of keratinocyte differentiation
0.42	GO:0070268	cornification
0.37	GO:0042633	hair cycle
0.36	GO:0007568	aging
0.31	GO:0007010	cytoskeleton organization

0.62	GO:0005198	structural molecule activity
0.35	GO:0005515	protein binding

0.79	GO:0005882	intermediate filament
0.40	GO:0070062	extracellular exosome
0.38	GO:0005829	cytosol

sp|O76021|RL1D1_HUMAN
Ribosomal L1 domain-containing protein 1
Search

RSL1D1

0.92	Ribosomal L1 domain-containing protein 1

0.81	GO:2000772	regulation of cellular senescence
0.69	GO:0042981	regulation of apoptotic process
0.68	GO:0032880	regulation of protein localization
0.61	GO:0000470	maturation of LSU-rRNA
0.49	GO:0043043	peptide biosynthetic process
0.46	GO:0044267	cellular protein metabolic process
0.44	GO:0009059	macromolecule biosynthetic process
0.42	GO:0001649	osteoblast differentiation
0.34	GO:0045454	cell redox homeostasis
0.33	GO:0017062	respiratory chain complex III assembly

0.76	GO:0003730	mRNA 3'-UTR binding
0.75	GO:0048027	mRNA 5'-UTR binding
0.74	GO:0045296	cadherin binding
0.38	GO:0003735	structural constituent of ribosome
0.33	GO:0046872	metal ion binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0004386	helicase activity

0.69	GO:0005730	nucleolus
0.60	GO:0030686	90S preribosome
0.60	GO:0022625	cytosolic large ribosomal subunit
0.32	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

sp|O76024|WFS1_HUMAN
Wolframin
Search

WFS1

0.96	Wolfram syndrome 1 (Wolframin)

0.80	GO:0055074	calcium ion homeostasis
0.65	GO:1903892	negative regulation of ATF6-mediated unfolded protein response
0.63	GO:2000675	negative regulation of type B pancreatic cell apoptotic process
0.62	GO:0003091	renal water homeostasis
0.61	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.61	GO:0045762	positive regulation of adenylate cyclase activity
0.59	GO:0051928	positive regulation of calcium ion transport
0.59	GO:0043524	negative regulation of neuron apoptotic process
0.58	GO:0043433	negative regulation of DNA binding transcription factor activity
0.58	GO:0042593	glucose homeostasis

0.60	GO:0051117	ATPase binding
0.56	GO:0031625	ubiquitin protein ligase binding
0.43	GO:0048306	calcium-dependent protein binding
0.42	GO:0033613	activating transcription factor binding
0.41	GO:0005516	calmodulin binding
0.34	GO:0004373	glycogen (starch) synthase activity

0.70	GO:0005783	endoplasmic reticulum
0.52	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.50	GO:0031984	organelle subcompartment
0.39	GO:1905369	endopeptidase complex
0.38	GO:0030425	dendrite
0.36	GO:0043234	protein complex
0.34	GO:0070013	intracellular organelle lumen
0.30	GO:0016021	integral component of membrane

0.34

EC:2.4.1.11

GO:0004373

sp|O76027|ANXA9_HUMAN
Annexin A9
Search

ANXA9

0.56

Annexin

0.57	GO:0098609	cell-cell adhesion
0.49	GO:0007165	signal transduction
0.44	GO:0051560	mitochondrial calcium ion homeostasis
0.43	GO:0006937	regulation of muscle contraction
0.42	GO:0006915	apoptotic process
0.41	GO:0006816	calcium ion transport
0.41	GO:0051260	protein homooligomerization
0.39	GO:0043086	negative regulation of catalytic activity
0.38	GO:0050819	negative regulation of coagulation
0.37	GO:0034220	ion transmembrane transport

0.81	GO:0005544	calcium-dependent phospholipid binding
0.70	GO:0005509	calcium ion binding
0.63	GO:0001786	phosphatidylserine binding
0.62	GO:0015464	acetylcholine receptor activity
0.43	GO:0048306	calcium-dependent protein binding
0.43	GO:0015485	cholesterol binding
0.42	GO:0042803	protein homodimerization activity
0.42	GO:0004859	phospholipase inhibitor activity
0.41	GO:0015276	ligand-gated ion channel activity
0.38	GO:0032550	purine ribonucleoside binding

0.56	GO:0009986	cell surface
0.52	GO:0005829	cytosol
0.42	GO:0031902	late endosome membrane
0.42	GO:0005765	lysosomal membrane
0.42	GO:0048471	perinuclear region of cytoplasm
0.40	GO:0070062	extracellular exosome
0.38	GO:0005739	mitochondrion
0.36	GO:0042470	melanosome
0.34	GO:0005925	focal adhesion

sp|O76031|CLPX_HUMAN
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
Search

CLPX

0.94	Caseinolytic mitochondrial matrix peptidase chaperone subunit

0.69	GO:0006457	protein folding
0.53	GO:0010952	positive regulation of peptidase activity
0.52	GO:0006508	proteolysis
0.50	GO:0030163	protein catabolic process
0.47	GO:0044265	cellular macromolecule catabolic process
0.44	GO:0046034	ATP metabolic process
0.41	GO:0044267	cellular protein metabolic process
0.36	GO:0048821	erythrocyte development

0.71	GO:0051082	unfolded protein binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0016504	peptidase activator activity
0.53	GO:0008233	peptidase activity
0.46	GO:0042623	ATPase activity, coupled
0.34	GO:0046872	metal ion binding

0.58	GO:0009841	mitochondrial endopeptidase Clp complex
0.53	GO:0042645	mitochondrial nucleoid
0.48	GO:0005654	nucleoplasm
0.47	GO:0005829	cytosol
0.44	GO:0031966	mitochondrial membrane
0.44	GO:0019866	organelle inner membrane

0.53

GO:0008233

sp|O76036|NCTR1_HUMAN
Natural cytotoxicity triggering receptor 1
Search

NCR1

0.97	Natural cytotoxicity triggering receptor

0.39	GO:0009597	detection of virus
0.39	GO:0002376	immune system process
0.38	GO:0006952	defense response
0.38	GO:0042269	regulation of natural killer cell mediated cytotoxicity
0.37	GO:0001775	cell activation
0.35	GO:0007165	signal transduction
0.34	GO:0034156	negative regulation of toll-like receptor 7 signaling pathway
0.34	GO:0051241	negative regulation of multicellular organismal process
0.33	GO:0034164	negative regulation of toll-like receptor 9 signaling pathway
0.33	GO:1900454	positive regulation of long term synaptic depression

0.36	GO:0005057	signal transducer activity, downstream of receptor
0.36	GO:0005515	protein binding
0.33	GO:0001540	amyloid-beta binding
0.33	GO:0015026	coreceptor activity
0.32	GO:0044877	macromolecular complex binding

0.37	GO:0016514	SWI/SNF complex
0.37	GO:0005886	plasma membrane
0.33	GO:0106003	amyloid-beta complex
0.32	GO:0098796	membrane protein complex
0.30	GO:0031224	intrinsic component of membrane

sp|O76038|SEGN_HUMAN
Secretagogin
Search

SCGN

0.97	Secretagogin

0.50	GO:0051480	regulation of cytosolic calcium ion concentration
0.44	GO:0007420	brain development
0.34	GO:0072027	connecting tubule development
0.34	GO:0072221	metanephric distal convoluted tubule development
0.34	GO:0035502	metanephric part of ureteric bud development
0.34	GO:0072205	metanephric collecting duct development
0.34	GO:1900271	regulation of long-term synaptic potentiation
0.33	GO:0007614	short-term memory
0.33	GO:0010842	retina layer formation
0.33	GO:0007616	long-term memory

0.70	GO:0005509	calcium ion binding
0.32	GO:0008270	zinc ion binding

0.48	GO:0043005	neuron projection
0.47	GO:0045202	synapse
0.45	GO:0005829	cytosol
0.42	GO:0005634	nucleus
0.40	GO:0030658	transport vesicle membrane
0.38	GO:0005576	extracellular region
0.33	GO:0043025	neuronal cell body
0.33	GO:0120038	plasma membrane bounded cell projection part
0.30	GO:0016021	integral component of membrane

sp|O76039|CDKL5_HUMAN
Cyclin-dependent kinase-like 5
Search

CDKL5

0.95	Cyclin dependent kinase like 5

0.62	GO:0006468	protein phosphorylation
0.48	GO:0045773	positive regulation of axon extension
0.48	GO:0050773	regulation of dendrite development
0.39	GO:0001764	neuron migration
0.38	GO:0043547	positive regulation of GTPase activity
0.37	GO:0051726	regulation of cell cycle

0.63	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0060089	molecular transducer activity
0.39	GO:0048365	Rac GTPase binding

0.50	GO:0005654	nucleoplasm
0.49	GO:0005829	cytosol
0.49	GO:0032839	dendrite cytoplasm
0.40	GO:0044294	dendritic growth cone
0.39	GO:0032587	ruffle membrane
0.39	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0045202	synapse
0.30	GO:0031224	intrinsic component of membrane

sp|O76041|NEBL_HUMAN
Nebulette
Search

0.54

Nebulette

0.44	GO:0071691	cardiac muscle thin filament assembly
0.37	GO:0030832	regulation of actin filament length
0.36	GO:0030240	skeletal muscle thin filament assembly
0.36	GO:0045214	sarcomere organization
0.35	GO:1901880	negative regulation of protein depolymerization
0.35	GO:1902904	negative regulation of supramolecular fiber organization
0.35	GO:0051494	negative regulation of cytoskeleton organization
0.35	GO:0110053	regulation of actin filament organization
0.33	GO:0016310	phosphorylation

0.61	GO:0003779	actin binding
0.47	GO:0046872	metal ion binding
0.44	GO:0031005	filamin binding
0.43	GO:0005523	tropomyosin binding
0.41	GO:0032403	protein complex binding
0.37	GO:0031014	troponin T binding
0.33	GO:0016301	kinase activity
0.30	GO:0008307	structural constituent of muscle

0.46	GO:0030018	Z disc
0.42	GO:0097517	contractile actin filament bundle
0.42	GO:0042641	actomyosin
0.37	GO:0005865	striated muscle thin filament
0.37	GO:0098723	skeletal muscle myofibril
0.35	GO:0070062	extracellular exosome
0.33	GO:0043234	protein complex

sp|O76042|ERIT1_HUMAN
Putative uncharacterized protein encoded by ERC2-IT1
Search

sp|O76050|NEUL1_HUMAN
E3 ubiquitin-protein ligase NEURL1
Search

NEURL1

0.95	Neuralized E3 ubiquitin protein ligase 1

0.87	GO:0048170	positive regulation of long-term neuronal synaptic plasticity
0.86	GO:0090129	positive regulation of synapse maturation
0.86	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
0.86	GO:0007288	sperm axoneme assembly
0.85	GO:0060999	positive regulation of dendritic spine development
0.85	GO:0045746	negative regulation of Notch signaling pathway
0.85	GO:0051491	positive regulation of filopodium assembly
0.83	GO:0071230	cellular response to amino acid stimulus
0.83	GO:0007595	lactation
0.82	GO:0006513	protein monoubiquitination

0.88	GO:0045183	translation factor activity, non-nucleic acid binding
0.75	GO:0061630	ubiquitin protein ligase activity

0.86	GO:0097440	apical dendrite
0.84	GO:0043204	perikaryon
0.84	GO:0043197	dendritic spine
0.82	GO:0014069	postsynaptic density
0.56	GO:0005886	plasma membrane
0.48	GO:0005737	cytoplasm

sp|O76054|S14L2_HUMAN
SEC14-like protein 2
Search

SEC14L3

0.84	Putative phosphatidylinositol transfer protein sec14

0.54	GO:0045540	regulation of cholesterol biosynthetic process
0.48	GO:0090205	positive regulation of cholesterol metabolic process
0.47	GO:0009891	positive regulation of biosynthetic process
0.46	GO:0006351	transcription, DNA-templated
0.45	GO:1903506	regulation of nucleic acid-templated transcription
0.45	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.45	GO:0010468	regulation of gene expression
0.43	GO:0051254	positive regulation of RNA metabolic process
0.42	GO:0043085	positive regulation of catalytic activity

0.60	GO:0008289	lipid binding
0.49	GO:0008431	vitamin E binding
0.43	GO:0008047	enzyme activator activity
0.41	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups
0.38	GO:0005515	protein binding
0.37	GO:0043168	anion binding

0.62	GO:0005829	cytosol
0.58	GO:0070062	extracellular exosome
0.57	GO:0005634	nucleus

0.41

EC:2.5 EC:2.5.1

GO:0016765

sp|O76061|STC2_HUMAN
Stanniocalcin-2
Search

STC2

0.97	Stanniocalcin-2

0.76	GO:0010469	regulation of receptor activity
0.61	GO:0046885	regulation of hormone biosynthetic process
0.58	GO:0040015	negative regulation of multicellular organism growth
0.57	GO:2001256	regulation of store-operated calcium entry
0.55	GO:0030968	endoplasmic reticulum unfolded protein response
0.54	GO:0006874	cellular calcium ion homeostasis
0.50	GO:0010629	negative regulation of gene expression
0.49	GO:0006979	response to oxidative stress
0.42	GO:0046697	decidualization
0.42	GO:0033280	response to vitamin D

0.79	GO:0005179	hormone activity
0.55	GO:0042803	protein homodimerization activity
0.52	GO:0019899	enzyme binding
0.48	GO:0020037	heme binding
0.33	GO:0043565	sequence-specific DNA binding

0.66	GO:0005576	extracellular region
0.57	GO:0048471	perinuclear region of cytoplasm
0.52	GO:0005783	endoplasmic reticulum
0.50	GO:0005794	Golgi apparatus
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.33	GO:0005634	nucleus

sp|O76062|ERG24_HUMAN
Delta(14)-sterol reductase
Search

TM7SF2

0.80	Lamin-B receptor

0.52	GO:0055114	oxidation-reduction process
0.49	GO:0016126	sterol biosynthetic process
0.39	GO:0008203	cholesterol metabolic process
0.38	GO:1902653	secondary alcohol biosynthetic process
0.36	GO:0045540	regulation of cholesterol biosynthetic process
0.34	GO:0042074	cell migration involved in gastrulation
0.33	GO:0000278	mitotic cell cycle

0.73	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
0.54	GO:0070087	chromo shadow domain binding
0.36	GO:0050661	NADP binding
0.34	GO:0005521	lamin binding
0.34	GO:0008139	nuclear localization sequence binding
0.34	GO:0003677	DNA binding
0.34	GO:0051087	chaperone binding
0.33	GO:0003723	RNA binding

0.55	GO:0031965	nuclear membrane
0.52	GO:0005783	endoplasmic reticulum
0.51	GO:0043235	receptor complex
0.46	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.44	GO:0031984	organelle subcompartment
0.43	GO:0019866	organelle inner membrane
0.40	GO:0031301	integral component of organelle membrane
0.34	GO:0005652	nuclear lamina
0.34	GO:0005887	integral component of plasma membrane
0.34	GO:0005643	nuclear pore

0.73

EC:1.3.1

GO:0016628

sp|O76064|RNF8_HUMAN
E3 ubiquitin-protein ligase RNF8
Search

RNF8

0.89	E3 ubiquitin-protein ligase rnf8-A

0.81	GO:0033522	histone H2A ubiquitination
0.81	GO:0033523	histone H2B ubiquitination
0.78	GO:0045739	positive regulation of DNA repair
0.76	GO:0010212	response to ionizing radiation
0.70	GO:0070534	protein K63-linked ubiquitination
0.70	GO:0006302	double-strand break repair
0.63	GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter
0.62	GO:0070936	protein K48-linked ubiquitination
0.60	GO:0051865	protein autoubiquitination
0.57	GO:0051301	cell division

0.73	GO:0042393	histone binding
0.73	GO:0043130	ubiquitin binding
0.71	GO:0003682	chromatin binding
0.69	GO:0004842	ubiquitin-protein transferase activity
0.62	GO:0042803	protein homodimerization activity
0.56	GO:0031625	ubiquitin protein ligase binding
0.52	GO:0016874	ligase activity
0.51	GO:0046872	metal ion binding
0.40	GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity
0.37	GO:0061659	ubiquitin-like protein ligase activity

0.70	GO:0000151	ubiquitin ligase complex
0.67	GO:0000781	chromosome, telomeric region
0.60	GO:0035861	site of double-strand break
0.58	GO:0005634	nucleus
0.52	GO:0030496	midbody
0.51	GO:0005829	cytosol
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0012505	endomembrane system
0.30	GO:0016021	integral component of membrane

0.52	EC:6	GO:0016874
0.69	KEGG:R03876	GO:0004842

sp|O76070|SYUG_HUMAN
Gamma-synuclein
Search

SNCG

0.97	Gamma-synuclein

0.69	GO:0050808	synapse organization
0.68	GO:0014059	regulation of dopamine secretion
0.66	GO:0007268	chemical synaptic transmission
0.66	GO:0046928	regulation of neurotransmitter secretion
0.65	GO:0008344	adult locomotory behavior
0.56	GO:0009306	protein secretion
0.55	GO:0042417	dopamine metabolic process
0.53	GO:0043524	negative regulation of neuron apoptotic process
0.42	GO:0008345	larval locomotory behavior
0.42	GO:0071542	dopaminergic neuron differentiation

0.56	GO:1903136	cuprous ion binding
0.47	GO:0005509	calcium ion binding
0.39	GO:0005515	protein binding
0.35	GO:0004859	phospholipase inhibitor activity

0.63	GO:0043025	neuronal cell body
0.62	GO:0030424	axon
0.53	GO:0016234	inclusion body
0.50	GO:0045202	synapse
0.48	GO:0005737	cytoplasm
0.43	GO:0005819	spindle
0.42	GO:0005815	microtubule organizing center
0.42	GO:0043227	membrane-bounded organelle
0.39	GO:0043230	extracellular organelle
0.38	GO:0044306	neuron projection terminus

sp|O76071|CIAO1_HUMAN
Probable cytosolic iron-sulfur protein assembly protein CIAO1
Search

CIAO1

0.84	Cytosolic iron-sulfur assembly component 1

0.72	GO:0031163	metallo-sulfur cluster assembly
0.64	GO:0006790	sulfur compound metabolic process
0.61	GO:0051188	cofactor biosynthetic process
0.58	GO:0007059	chromosome segregation
0.36	GO:0006357	regulation of transcription by RNA polymerase II
0.35	GO:0008284	positive regulation of cell proliferation
0.32	GO:0006468	protein phosphorylation
0.32	GO:0007186	G-protein coupled receptor signaling pathway

0.34	GO:0005515	protein binding
0.33	GO:0004683	calmodulin-dependent protein kinase activity
0.33	GO:0003700	DNA binding transcription factor activity
0.32	GO:0004930	G-protein coupled receptor activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0016746	transferase activity, transferring acyl groups

0.83	GO:0097361	CIA complex
0.72	GO:0071817	MMXD complex
0.33	GO:0019013	viral nucleocapsid
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:2.7.11.17

GO:0004683

sp|O76074|PDE5A_HUMAN
cGMP-specific 3',5'-cyclic phosphodiesterase
Search

PDE5A

0.58	Phosphodiesterase

0.61	GO:0046069	cGMP catabolic process
0.60	GO:0007165	signal transduction
0.57	GO:0055118	negative regulation of cardiac muscle contraction
0.57	GO:0055119	relaxation of cardiac muscle
0.57	GO:0060282	positive regulation of oocyte development
0.56	GO:0014742	positive regulation of muscle hypertrophy
0.55	GO:0010611	regulation of cardiac muscle hypertrophy
0.55	GO:0030823	regulation of cGMP metabolic process
0.55	GO:0042130	negative regulation of T cell proliferation
0.52	GO:0043406	positive regulation of MAP kinase activity

0.78	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.55	GO:0030553	cGMP binding
0.53	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.36

GO:0005829

cytosol

0.78

GO:0004114

sp|O76075|DFFB_HUMAN
DNA fragmentation factor subunit beta
Search

DFFB

0.97	DNAation factor subunit beta

0.85	GO:0006309	apoptotic DNA fragmentation
0.41	GO:0030263	apoptotic chromosome condensation
0.39	GO:0051260	protein homooligomerization
0.35	GO:0007420	brain development

0.51	GO:0016787	hydrolase activity
0.42	GO:0140097	catalytic activity, acting on DNA
0.42	GO:0003677	DNA binding
0.40	GO:0097718	disordered domain specific binding
0.38	GO:0042802	identical protein binding
0.37	GO:0019899	enzyme binding

0.61	GO:0005634	nucleus
0.49	GO:0031974	membrane-enclosed lumen
0.49	GO:0005737	cytoplasm
0.46	GO:0000785	chromatin
0.30	GO:0031224	intrinsic component of membrane

0.51

GO:0016787

sp|O76076|WISP2_HUMAN
WNT1-inducible-signaling pathway protein 2
Search

WISP2

0.93	Connective tissue growth factor a

0.79	GO:0001558	regulation of cell growth
0.50	GO:0035988	chondrocyte proliferation
0.50	GO:0007155	cell adhesion
0.50	GO:0001502	cartilage condensation
0.49	GO:0051496	positive regulation of stress fiber assembly
0.49	GO:0032330	regulation of chondrocyte differentiation
0.48	GO:0060548	negative regulation of cell death
0.48	GO:0046330	positive regulation of JNK cascade
0.48	GO:0030324	lung development
0.48	GO:0008543	fibroblast growth factor receptor signaling pathway

0.84	GO:0005520	insulin-like growth factor binding
0.56	GO:0005178	integrin binding
0.55	GO:0008201	heparin binding
0.48	GO:0008022	protein C-terminus binding
0.37	GO:0008083	growth factor activity
0.37	GO:0001968	fibronectin binding
0.34	GO:0019904	protein domain specific binding
0.33	GO:0004930	G-protein coupled receptor activity

0.66	GO:0005576	extracellular region
0.38	GO:0005829	cytosol
0.36	GO:0005801	cis-Golgi network
0.36	GO:0031982	vesicle
0.36	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0005938	cell cortex
0.34	GO:0009986	cell surface
0.34	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O76080|ZFAN5_HUMAN
AN1-type zinc finger protein 5
Search

ZFAND5

0.95	Zinc finger A20 domain-containing protein 2

0.57	GO:0010761	fibroblast migration
0.57	GO:0003016	respiratory system process
0.56	GO:0048745	smooth muscle tissue development
0.55	GO:0048008	platelet-derived growth factor receptor signaling pathway
0.55	GO:0060324	face development
0.53	GO:0048705	skeletal system morphogenesis
0.52	GO:0001944	vasculature development
0.50	GO:0001701	in utero embryonic development
0.37	GO:0071356	cellular response to tumor necrosis factor
0.37	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling

0.63	GO:0008270	zinc ion binding
0.54	GO:0003677	DNA binding
0.37	GO:0031593	polyubiquitin modification-dependent protein binding

0.33

GO:0005737

cytoplasm

sp|O76081|RGS20_HUMAN
Regulator of G-protein signaling 20
Search

RGS20

0.87	LOW QUALITY PROTEIN: regulator of G-protein signaling 20

0.66	GO:0043547	positive regulation of GTPase activity
0.50	GO:0009968	negative regulation of signal transduction
0.44	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.40	GO:0007186	G-protein coupled receptor signaling pathway

0.66	GO:0005096	GTPase activator activity
0.39	GO:0005515	protein binding

0.74	GO:0005802	trans-Golgi network
0.63	GO:0031410	cytoplasmic vesicle
0.50	GO:0005886	plasma membrane
0.45	GO:0005634	nucleus
0.40	GO:0043005	neuron projection
0.40	GO:0045202	synapse
0.40	GO:0030054	cell junction

sp|O76082|S22A5_HUMAN
Solute carrier family 22 member 5
Search

SLC22A5

0.90	LOW QUALITY PROTEIN: solute carrier family 22 member 5

0.66	GO:1902603	carnitine transmembrane transport
0.59	GO:0070715	sodium-dependent organic cation transport
0.59	GO:0060731	positive regulation of intestinal epithelial structure maintenance
0.58	GO:0052097	interspecies quorum sensing
0.57	GO:0009437	carnitine metabolic process
0.51	GO:0006641	triglyceride metabolic process
0.46	GO:0072337	modified amino acid transport
0.45	GO:0051701	interaction with host
0.45	GO:0015711	organic anion transport
0.40	GO:0006814	sodium ion transport

0.66	GO:0015226	carnitine transmembrane transporter activity
0.63	GO:0030165	PDZ domain binding
0.54	GO:0015491	cation:cation antiporter activity
0.46	GO:0008514	organic anion transmembrane transporter activity
0.40	GO:0015293	symporter activity
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0008513	secondary active organic cation transmembrane transporter activity
0.36	GO:0015238	drug transmembrane transporter activity

0.61	GO:0016324	apical plasma membrane
0.55	GO:0031526	brush border membrane
0.45	GO:0005887	integral component of plasma membrane
0.43	GO:0005739	mitochondrion
0.37	GO:0070062	extracellular exosome
0.35	GO:0016323	basolateral plasma membrane
0.35	GO:0031231	intrinsic component of peroxisomal membrane

sp|O76083|PDE9A_HUMAN
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Search

PDE9A

0.55	Phosphodiesterase

0.60	GO:0007165	signal transduction
0.57	GO:0046069	cGMP catabolic process
0.56	GO:0014742	positive regulation of muscle hypertrophy
0.56	GO:0010611	regulation of cardiac muscle hypertrophy
0.31	GO:0055085	transmembrane transport

0.79	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.54	GO:0046872	metal ion binding
0.37	GO:0042802	identical protein binding

0.54	GO:0042383	sarcolemma
0.40	GO:0043204	perikaryon
0.40	GO:0032587	ruffle membrane
0.39	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0005794	Golgi apparatus
0.37	GO:0005783	endoplasmic reticulum
0.35	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.79

GO:0004114

sp|O76087|GAGE7_HUMAN
G antigen 7
Search

0.97	G antigen family B member 1

0.62

GO:0006968

cellular defense response

0.58

GO:0005515

protein binding

sp|O76090|BEST1_HUMAN
Bestrophin-1
Search

BEST1

0.67	Bestrophin

0.77	GO:1902476	chloride transmembrane transport
0.71	GO:0007601	visual perception
0.56	GO:0030321	transepithelial chloride transport
0.56	GO:0050962	detection of light stimulus involved in sensory perception
0.55	GO:0043269	regulation of ion transport
0.52	GO:0009584	detection of visible light
0.46	GO:0051051	negative regulation of transport
0.36	GO:0015701	bicarbonate transport

0.78	GO:0005254	chloride channel activity
0.49	GO:0042802	identical protein binding
0.36	GO:0015106	bicarbonate transmembrane transporter activity
0.35	GO:0022839	ion gated channel activity
0.35	GO:0008381	mechanosensitive ion channel activity
0.32	GO:0046872	metal ion binding

0.81	GO:0034707	chloride channel complex
0.55	GO:0005886	plasma membrane
0.34	GO:0005829	cytosol

sp|O76093|FGF18_HUMAN
Fibroblast growth factor 18
Search

FGF18

0.61	Fibroblast growth factor

0.84	GO:0008543	fibroblast growth factor receptor signaling pathway
0.76	GO:0010469	regulation of receptor activity
0.58	GO:1904849	positive regulation of cell chemotaxis to fibroblast growth factor
0.58	GO:0001957	intramembranous ossification
0.58	GO:2000544	regulation of endothelial cell chemotaxis to fibroblast growth factor
0.57	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
0.57	GO:2001028	positive regulation of endothelial cell chemotaxis
0.57	GO:0032332	positive regulation of chondrocyte differentiation
0.56	GO:0001958	endochondral ossification
0.56	GO:0002063	chondrocyte development

0.85	GO:0005104	fibroblast growth factor receptor binding
0.78	GO:0008083	growth factor activity
0.36	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.35	GO:0016303	1-phosphatidylinositol-3-kinase activity
0.34	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.34	GO:0004713	protein tyrosine kinase activity
0.32	GO:0003676	nucleic acid binding

0.66	GO:0005576	extracellular region
0.49	GO:0005730	nucleolus
0.32	GO:0005737	cytoplasm

0.36	EC:2.7.1.153	GO:0046934
0.36	KEGG:R04545	GO:0046934

sp|O76094|SRP72_HUMAN
Signal recognition particle subunit SRP72
Search

SRP72

0.74	Signal recognition particle 72

0.75	GO:0006614	SRP-dependent cotranslational protein targeting to membrane
0.49	GO:0042493	response to drug
0.44	GO:0065002	intracellular protein transmembrane transport

0.74	GO:0008312	7S RNA binding
0.60	GO:0030911	TPR domain binding
0.56	GO:0005047	signal recognition particle binding
0.51	GO:0043022	ribosome binding
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0019001	guanyl nucleotide binding
0.34	GO:0032555	purine ribonucleotide binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.73	GO:0048500	signal recognition particle
0.49	GO:0005783	endoplasmic reticulum
0.37	GO:0005730	nucleolus
0.35	GO:0005829	cytosol

sp|O76095|JTB_HUMAN
Protein JTB
Search

JTB

0.97	Jumping translocation breakpoint

0.73	GO:0008637	apoptotic mitochondrial changes
0.69	GO:0000281	mitotic cytokinesis
0.67	GO:0045860	positive regulation of protein kinase activity
0.65	GO:0042127	regulation of cell proliferation

0.67

GO:0019901

protein kinase binding

0.71	GO:0030496	midbody
0.67	GO:0005813	centrosome
0.66	GO:0005819	spindle
0.53	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

sp|O76096|CYTF_HUMAN
Cystatin-F
Search

CST7

0.73	Cystatin-F

0.76	GO:0010951	negative regulation of endopeptidase activity
0.52	GO:2000116	regulation of cysteine-type endopeptidase activity
0.36	GO:0006955	immune response
0.35	GO:0010711	negative regulation of collagen catabolic process
0.35	GO:0060311	negative regulation of elastin catabolic process
0.35	GO:0060313	negative regulation of blood vessel remodeling
0.35	GO:0010716	negative regulation of extracellular matrix disassembly
0.33	GO:0097435	supramolecular fiber organization
0.33	GO:0006952	defense response

0.83	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.53	GO:0002020	protease binding
0.34	GO:0001540	amyloid-beta binding
0.33	GO:0042802	identical protein binding

0.48	GO:0005615	extracellular space
0.33	GO:0005737	cytoplasm

sp|O76099|OR7C1_HUMAN
Olfactory receptor 7C1
Search

0.45	Olfactory receptor

0.75	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.35	GO:0007283	spermatogenesis

0.75	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O76100|OR7AA_HUMAN
Olfactory receptor 7A10
Search

0.45	Olfactory receptor

0.75	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.70	GO:0007186	G-protein coupled receptor signaling pathway

0.75	GO:0004984	olfactory receptor activity
0.70	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O77932|DXO_HUMAN
Decapping and exoribonuclease protein
Search

DXO

0.97	Decapping exoribonuclease

0.52	GO:0050779	RNA destabilization
0.51	GO:0071028	nuclear mRNA surveillance
0.43	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.55	GO:0034353	RNA pyrophosphohydrolase activity
0.48	GO:0008409	5'-3' exonuclease activity
0.48	GO:0003729	mRNA binding
0.43	GO:0000287	magnesium ion binding
0.39	GO:1901265	nucleoside phosphate binding
0.38	GO:0036094	small molecule binding

0.67	GO:0005829	cytosol
0.61	GO:0005634	nucleus
0.55	GO:0005886	plasma membrane

sp|O94759|TRPM2_HUMAN
Transient receptor potential cation channel subfamily M member 2
Search

TRPM2

0.93	Transient receptor potential melastatin 2

0.70	GO:0006979	response to oxidative stress
0.64	GO:0071502	cellular response to temperature stimulus
0.63	GO:0071415	cellular response to purine-containing compound
0.62	GO:0002407	dendritic cell chemotaxis
0.61	GO:0035584	calcium-mediated signaling using intracellular calcium source
0.61	GO:0097028	dendritic cell differentiation
0.61	GO:0098703	calcium ion import across plasma membrane
0.61	GO:0001659	temperature homeostasis
0.59	GO:0051209	release of sequestered calcium ion into cytosol
0.57	GO:0071421	manganese ion transmembrane transport

0.82	GO:0047631	ADP-ribose diphosphatase activity
0.73	GO:0005261	cation channel activity
0.58	GO:0005384	manganese ion transmembrane transporter activity
0.55	GO:0015085	calcium ion transmembrane transporter activity
0.54	GO:0015276	ligand-gated ion channel activity
0.48	GO:0004871	signal transducer activity
0.39	GO:0015081	sodium ion transmembrane transporter activity
0.38	GO:0005509	calcium ion binding

0.58	GO:0005765	lysosomal membrane
0.55	GO:0030659	cytoplasmic vesicle membrane
0.50	GO:0005887	integral component of plasma membrane
0.42	GO:0043025	neuronal cell body
0.39	GO:0043005	neuron projection
0.38	GO:0101002	ficolin-1-rich granule
0.38	GO:0070820	tertiary granule
0.37	GO:0042581	specific granule
0.34	GO:0034706	sodium channel complex
0.33	GO:0005794	Golgi apparatus

0.82

EC:3.6.1.13

GO:0047631

sp|O94760|DDAH1_HUMAN
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Search

DDAH1

0.89	Dimethylarginine dimethylaminohydrolase I

0.85	GO:0000052	citrulline metabolic process
0.84	GO:0045429	positive regulation of nitric oxide biosynthetic process
0.74	GO:0006527	arginine catabolic process
0.58	GO:0043116	negative regulation of vascular permeability
0.57	GO:1900038	negative regulation of cellular response to hypoxia
0.55	GO:0003073	regulation of systemic arterial blood pressure
0.52	GO:0008285	negative regulation of cell proliferation
0.40	GO:0045766	positive regulation of angiogenesis
0.38	GO:0017014	protein nitrosylation
0.37	GO:0006809	nitric oxide biosynthetic process

0.85	GO:0016403	dimethylargininase activity
0.38	GO:0016597	amino acid binding
0.35	GO:0046872	metal ion binding

0.44	GO:0005739	mitochondrion
0.37	GO:0070062	extracellular exosome
0.35	GO:0005829	cytosol
0.34	GO:0005815	microtubule organizing center

0.85

EC:3.5.3.18

GO:0016403

sp|O94761|RECQ4_HUMAN
ATP-dependent DNA helicase Q4
Search

RECQL4

0.84	RecQ like helicase 4

0.61	GO:0006310	DNA recombination
0.49	GO:0006302	double-strand break repair
0.48	GO:0006284	base-excision repair
0.47	GO:0032392	DNA geometric change
0.45	GO:0006260	DNA replication
0.45	GO:0061820	telomeric D-loop disassembly
0.40	GO:0007275	multicellular organism development
0.40	GO:0045875	negative regulation of sister chromatid cohesion
0.40	GO:0008284	positive regulation of cell proliferation
0.39	GO:0043473	pigmentation

0.66	GO:0070035	purine NTP-dependent helicase activity
0.60	GO:0042623	ATPase activity, coupled
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008270	zinc ion binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0043138	3'-5' DNA helicase activity
0.51	GO:0003676	nucleic acid binding
0.49	GO:0009378	four-way junction helicase activity
0.36	GO:0005515	protein binding

0.50	GO:0005634	nucleus
0.46	GO:0005694	chromosome
0.38	GO:0005737	cytoplasm
0.37	GO:0044446	intracellular organelle part
0.35	GO:0005834	heterotrimeric G-protein complex
0.30	GO:0031224	intrinsic component of membrane

sp|O94762|RECQ5_HUMAN
ATP-dependent DNA helicase Q5
Search

RECQL5

0.69	RecQ like helicase 5

0.72	GO:0072757	cellular response to camptothecin
0.71	GO:0045910	negative regulation of DNA recombination
0.70	GO:1990414	replication-born double-strand break repair via sister chromatid exchange
0.70	GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter
0.69	GO:2000780	negative regulation of double-strand break repair
0.68	GO:0010569	regulation of double-strand break repair via homologous recombination
0.63	GO:0051304	chromosome separation
0.60	GO:0000278	mitotic cell cycle
0.58	GO:0032392	DNA geometric change
0.56	GO:0000019	regulation of mitotic recombination

0.71	GO:0070035	purine NTP-dependent helicase activity
0.67	GO:0000993	RNA polymerase II core binding
0.64	GO:0042623	ATPase activity, coupled
0.58	GO:0003678	DNA helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding

0.60	GO:0016591	DNA-directed RNA polymerase II, holoenzyme
0.56	GO:0005829	cytosol
0.44	GO:0005694	chromosome

sp|O94763|RMP_HUMAN
Unconventional prefoldin RPB5 interactor 1
Search

URI1

0.78	Unconventional prefoldin RPB5 interactor

0.82	GO:0010923	negative regulation of phosphatase activity
0.81	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway
0.78	GO:0000122	negative regulation of transcription by RNA polymerase II
0.75	GO:0001558	regulation of cell growth
0.75	GO:0071363	cellular response to growth factor stimulus
0.74	GO:0071383	cellular response to steroid hormone stimulus
0.73	GO:0009615	response to virus
0.42	GO:0035308	negative regulation of protein dephosphorylation
0.41	GO:0043666	regulation of phosphoprotein phosphatase activity
0.36	GO:0006351	transcription, DNA-templated

0.85	GO:0001106	RNA polymerase II transcription corepressor activity
0.78	GO:0051219	phosphoprotein binding
0.77	GO:0003682	chromatin binding
0.70	GO:0019212	phosphatase inhibitor activity
0.41	GO:0019888	protein phosphatase regulator activity

0.81	GO:0005665	DNA-directed RNA polymerase II, core complex
0.64	GO:0005829	cytosol
0.41	GO:0030425	dendrite
0.37	GO:0005739	mitochondrion

sp|O94766|B3GA3_HUMAN
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
Search

B3GAT3

0.77	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

0.74	GO:0043413	macromolecule glycosylation
0.74	GO:0009101	glycoprotein biosynthetic process
0.63	GO:0050654	chondroitin sulfate proteoglycan metabolic process
0.61	GO:0030201	heparan sulfate proteoglycan metabolic process
0.60	GO:0036211	protein modification process
0.60	GO:0050655	dermatan sulfate proteoglycan metabolic process
0.56	GO:0090316	positive regulation of intracellular protein transport
0.55	GO:0044267	cellular protein metabolic process
0.53	GO:0043666	regulation of phosphoprotein phosphatase activity
0.50	GO:0043085	positive regulation of catalytic activity

0.85	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
0.59	GO:0072542	protein phosphatase activator activity
0.54	GO:0046872	metal ion binding
0.36	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
0.34	GO:0030246	carbohydrate binding
0.34	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.34	GO:0005515	protein binding

0.74	GO:0000139	Golgi membrane
0.55	GO:0005801	cis-Golgi network
0.37	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.85

EC:2.4.1.135

GO:0015018

sp|O94768|ST17B_HUMAN
Serine/threonine-protein kinase 17B
Search

STK17B

0.97	Serine/threonine kinase 17b (Apoptosis-inducing)

0.68	GO:2000271	positive regulation of fibroblast apoptotic process
0.63	GO:0006468	protein phosphorylation
0.50	GO:0035556	intracellular signal transduction
0.41	GO:0006915	apoptotic process

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding

0.50	GO:0005634	nucleus
0.41	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.40	GO:0015629	actin cytoskeleton
0.35	GO:0005886	plasma membrane

sp|O94769|ECM2_HUMAN
Extracellular matrix protein 2
Search

ECM2

0.97	Extracellular matrix protein 2, female organ and adipocyte specific

0.79	GO:0010811	positive regulation of cell-substrate adhesion
0.75	GO:0030198	extracellular matrix organization
0.62	GO:0007409	axonogenesis
0.41	GO:0007160	cell-matrix adhesion
0.33	GO:0010951	negative regulation of endopeptidase activity
0.33	GO:0006336	DNA replication-independent nucleosome assembly
0.32	GO:0001558	regulation of cell growth
0.32	GO:0016310	phosphorylation
0.32	GO:0018212	peptidyl-tyrosine modification
0.32	GO:0007166	cell surface receptor signaling pathway

0.87	GO:0070052	collagen V binding
0.80	GO:0008201	heparin binding
0.42	GO:0005178	integrin binding
0.40	GO:0005201	extracellular matrix structural constituent
0.37	GO:0005509	calcium ion binding
0.34	GO:0004386	helicase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0004867	serine-type endopeptidase inhibitor activity
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.83	GO:0005614	interstitial matrix
0.58	GO:0005615	extracellular space
0.34	GO:0005581	collagen trimer
0.32	GO:0043189	H4/H2A histone acetyltransferase complex
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016773

sp|O94772|LY6H_HUMAN
Lymphocyte antigen 6H
Search

LY6H

0.97	Lymphocyte antigen 6 family member H

0.70	GO:2000272	negative regulation of receptor activity
0.68	GO:0095500	acetylcholine receptor signaling pathway
0.55	GO:0006501	C-terminal protein lipidation
0.50	GO:0009887	animal organ morphogenesis
0.49	GO:0007399	nervous system development

0.71	GO:0033130	acetylcholine receptor binding
0.71	GO:0030550	acetylcholine receptor inhibitor activity

0.71	GO:0031225	anchored component of membrane
0.51	GO:0005886	plasma membrane
0.46	GO:0005576	extracellular region

sp|O94776|MTA2_HUMAN
Metastasis-associated protein MTA2
Search

MTA2

0.96	Metastasis associated 1 family member 2

0.60	GO:0016575	histone deacetylation
0.58	GO:0000122	negative regulation of transcription by RNA polymerase II
0.57	GO:0045944	positive regulation of transcription by RNA polymerase II
0.56	GO:0006306	DNA methylation
0.53	GO:0031101	fin regeneration
0.44	GO:0060215	primitive hemopoiesis
0.44	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
0.42	GO:0008284	positive regulation of cell proliferation
0.41	GO:0010762	regulation of fibroblast migration
0.37	GO:0043044	ATP-dependent chromatin remodeling

0.76	GO:0003682	chromatin binding
0.64	GO:0001103	RNA polymerase II repressing transcription factor binding
0.64	GO:0043565	sequence-specific DNA binding
0.62	GO:0008270	zinc ion binding
0.60	GO:0003700	DNA binding transcription factor activity
0.60	GO:0004407	histone deacetylase activity
0.58	GO:0044212	transcription regulatory region DNA binding
0.56	GO:0000989	transcription factor activity, transcription factor binding
0.55	GO:0003690	double-stranded DNA binding
0.42	GO:0044877	macromolecular complex binding

0.81	GO:0090545	CHD-type complex
0.79	GO:0090568	nuclear transcriptional repressor complex
0.77	GO:0000118	histone deacetylase complex
0.56	GO:0005667	transcription factor complex
0.35	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.60

EC:3.5.1.98

GO:0004407

sp|O94777|DPM2_HUMAN
Dolichol phosphate-mannose biosynthesis regulatory protein
Search

DPM2

0.88	Dolichyl-phosphate mannosyltransferase 2 regulatory subunit

0.85	GO:0019348	dolichol metabolic process
0.69	GO:0050790	regulation of catalytic activity
0.58	GO:0097502	mannosylation
0.58	GO:0006506	GPI anchor biosynthetic process
0.56	GO:0031647	regulation of protein stability
0.51	GO:0006493	protein O-linked glycosylation
0.40	GO:0046854	phosphatidylinositol phosphorylation
0.38	GO:0006487	protein N-linked glycosylation
0.37	GO:0018196	peptidyl-asparagine modification
0.36	GO:0006397	mRNA processing

0.70	GO:0030234	enzyme regulator activity
0.63	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity
0.41	GO:0016307	phosphatidylinositol phosphate kinase activity
0.37	GO:0005515	protein binding
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding

0.78	GO:0030176	integral component of endoplasmic reticulum membrane
0.67	GO:0033185	dolichol-phosphate-mannose synthase complex
0.61	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
0.36	GO:0048471	perinuclear region of cytoplasm

0.63

EC:2.4.1.83

GO:0004582

sp|O94778|AQP8_HUMAN
Aquaporin-8
Search

AQP8

0.95	Putative mitochondrial malate dehydrogenase

0.63	GO:0006833	water transport
0.58	GO:0071320	cellular response to cAMP
0.55	GO:0055085	transmembrane transport
0.41	GO:0015840	urea transport
0.40	GO:0006811	ion transport
0.35	GO:0046717	acid secretion
0.35	GO:0032259	methylation
0.35	GO:0015850	organic hydroxy compound transport
0.34	GO:0006869	lipid transport
0.34	GO:0030437	ascospore formation

0.69	GO:0022803	passive transmembrane transporter activity
0.57	GO:0005372	water transmembrane transporter activity
0.41	GO:0015204	urea transmembrane transporter activity
0.35	GO:0008168	methyltransferase activity
0.32	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.55	GO:0045177	apical part of cell
0.43	GO:0005887	integral component of plasma membrane
0.35	GO:0042807	central vacuole
0.35	GO:0046930	pore complex
0.34	GO:0098590	plasma membrane region
0.34	GO:0009705	plant-type vacuole membrane
0.34	GO:0031410	cytoplasmic vesicle

0.35

GO:0008168

sp|O94779|CNTN5_HUMAN
Contactin-5
Search

CNTN5

0.86	Contactin-5

0.71	GO:0007605	sensory perception of sound
0.47	GO:0007155	cell adhesion
0.43	GO:0030182	neuron differentiation
0.42	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.42	GO:0000904	cell morphogenesis involved in differentiation
0.42	GO:0006501	C-terminal protein lipidation
0.41	GO:0120036	plasma membrane bounded cell projection organization
0.40	GO:0006935	chemotaxis
0.40	GO:0006928	movement of cell or subcellular component
0.37	GO:0045665	negative regulation of neuron differentiation

0.38

GO:0005112

Notch binding

0.65	GO:0005829	cytosol
0.44	GO:0031225	anchored component of membrane
0.38	GO:0005576	extracellular region
0.38	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O94782|UBP1_HUMAN
Ubiquitin carboxyl-terminal hydrolase 1
Search

USP1

0.95	Ubiquitin carboxyl-terminal hydrolase 1

0.76	GO:0006282	regulation of DNA repair
0.75	GO:0016579	protein deubiquitination
0.72	GO:0006511	ubiquitin-dependent protein catabolic process
0.57	GO:0009411	response to UV
0.56	GO:0001501	skeletal system development
0.37	GO:0006281	DNA repair
0.37	GO:0042769	DNA damage response, detection of DNA damage

0.75	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.72	GO:0004197	cysteine-type endopeptidase activity
0.34	GO:0005515	protein binding

0.51

GO:0005654

nucleoplasm

0.75

GO:0036459

sp|O94788|AL1A2_HUMAN
Retinal dehydrogenase 2
Search

ALDH1A2

0.88	Aldehyde dehydrogenase 1 family member A2

0.70	GO:0048384	retinoic acid receptor signaling pathway
0.69	GO:0060324	face development
0.69	GO:0035799	ureter maturation
0.69	GO:0042904	9-cis-retinoic acid biosynthetic process
0.68	GO:0031016	pancreas development
0.67	GO:0030902	hindbrain development
0.67	GO:0009855	determination of bilateral symmetry
0.67	GO:0048565	digestive tract development
0.67	GO:0042574	retinal metabolic process
0.66	GO:0060485	mesenchyme development

0.70	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity
0.68	GO:0001758	retinal dehydrogenase activity
0.50	GO:0004029	aldehyde dehydrogenase (NAD) activity

0.42

GO:0005737

cytoplasm

0.70

EC:1.2.1

GO:0004028

sp|O94804|STK10_HUMAN
Serine/threonine-protein kinase 10
Search

STK10

0.94	Serine/threonine-protein kinase 10-A

0.63	GO:0006468	protein phosphorylation
0.61	GO:2000401	regulation of lymphocyte migration
0.61	GO:0071593	lymphocyte aggregation
0.50	GO:0031098	stress-activated protein kinase signaling cascade
0.48	GO:0032147	activation of protein kinase activity
0.47	GO:0007346	regulation of mitotic cell cycle
0.47	GO:0042981	regulation of apoptotic process
0.39	GO:0007049	cell cycle
0.36	GO:0043312	neutrophil degranulation
0.36	GO:0051893	regulation of focal adhesion assembly

0.70	GO:0004674	protein serine/threonine kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0042803	protein homodimerization activity
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0045296	cadherin binding
0.32	GO:0035091	phosphatidylinositol binding

0.44	GO:0005886	plasma membrane
0.37	GO:0070062	extracellular exosome
0.37	GO:0005737	cytoplasm
0.36	GO:0031252	cell leading edge
0.35	GO:0012506	vesicle membrane
0.35	GO:0097708	intracellular vesicle
0.35	GO:0098805	whole membrane
0.34	GO:0098588	bounding membrane of organelle
0.34	GO:0012505	endomembrane system
0.33	GO:0044446	intracellular organelle part

0.70

GO:0004674

sp|O94805|ACL6B_HUMAN
Actin-like protein 6B
Search

ACTL6B

0.60	Actin-related protein 8

0.76	GO:0006338	chromatin remodeling
0.57	GO:0007399	nervous system development
0.54	GO:1903146	regulation of autophagy of mitochondrion
0.54	GO:0043968	histone H2A acetylation
0.54	GO:0003407	neural retina development
0.54	GO:1903955	positive regulation of protein targeting to mitochondrion
0.53	GO:0043967	histone H4 acetylation
0.37	GO:0040008	regulation of growth
0.36	GO:0006351	transcription, DNA-templated
0.36	GO:1903506	regulation of nucleic acid-templated transcription

0.50	GO:0003682	chromatin binding
0.37	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.36	GO:0003713	transcription coactivator activity
0.36	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0033570	transferrin transmembrane transporter activity
0.35	GO:0044877	macromolecular complex binding
0.35	GO:0005515	protein binding
0.34	GO:0005200	structural constituent of cytoskeleton

0.77	GO:0071564	npBAF complex
0.62	GO:0016514	SWI/SNF complex
0.53	GO:0071565	nBAF complex
0.52	GO:0035267	NuA4 histone acetyltransferase complex
0.51	GO:0031011	Ino80 complex
0.49	GO:0005730	nucleolus
0.41	GO:0005886	plasma membrane

sp|O94806|KPCD3_HUMAN
Serine/threonine-protein kinase D3
Search

PRKD3

0.49	Serine/threonine-protein kinase

0.63	GO:0006468	protein phosphorylation
0.62	GO:0035556	intracellular signal transduction
0.39	GO:0010837	regulation of keratinocyte proliferation
0.39	GO:0042993	positive regulation of transcription factor import into nucleus
0.39	GO:0045669	positive regulation of osteoblast differentiation
0.39	GO:0051279	regulation of release of sequestered calcium ion into cytosol
0.38	GO:0050829	defense response to Gram-negative bacterium
0.37	GO:0048193	Golgi vesicle transport
0.35	GO:0030148	sphingolipid biosynthetic process
0.35	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway

0.84	GO:0004697	protein kinase C activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.50	GO:0005829	cytosol
0.49	GO:0005654	nucleoplasm
0.38	GO:0005802	trans-Golgi network
0.37	GO:0005911	cell-cell junction
0.37	GO:0005938	cell cortex
0.34	GO:0005886	plasma membrane

0.84

EC:2.7.11.13

GO:0004697

sp|O94808|GFPT2_HUMAN
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
Search

GFPT2

0.81	Glutamine--fructose-6-phosphate aminotransferase

0.60	GO:1901137	carbohydrate derivative biosynthetic process
0.53	GO:1990830	cellular response to leukemia inhibitory factor
0.47	GO:0006047	UDP-N-acetylglucosamine metabolic process
0.47	GO:0006002	fructose 6-phosphate metabolic process
0.46	GO:0043413	macromolecule glycosylation
0.45	GO:0009100	glycoprotein metabolic process
0.41	GO:0036211	protein modification process
0.39	GO:0044267	cellular protein metabolic process
0.38	GO:1901566	organonitrogen compound biosynthetic process
0.38	GO:0032922	circadian regulation of gene expression

0.76	GO:0004360	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
0.54	GO:0097367	carbohydrate derivative binding
0.33	GO:0005515	protein binding
0.33	GO:0051536	iron-sulfur cluster binding
0.33	GO:0005506	iron ion binding

0.33

GO:0005829

cytosol

0.76	EC:2.6.1.16	GO:0004360
0.76	KEGG:R00768	GO:0004360

sp|O94810|RGS11_HUMAN
Regulator of G-protein signaling 11
Search

RGS11

0.94	Regulator of G protein signaling 9

0.69	GO:0007186	G-protein coupled receptor signaling pathway
0.61	GO:0035556	intracellular signal transduction
0.46	GO:0043547	positive regulation of GTPase activity
0.38	GO:0009968	negative regulation of signal transduction
0.38	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.36	GO:0007601	visual perception
0.36	GO:0043627	response to estrogen
0.35	GO:0007399	nervous system development

0.63	GO:0004871	signal transducer activity
0.56	GO:0031681	G-protein beta-subunit binding
0.46	GO:0005096	GTPase activator activity
0.35	GO:0032403	protein complex binding

0.79	GO:1905360	GTPase complex
0.78	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.64	GO:0098797	plasma membrane protein complex
0.47	GO:0001917	photoreceptor inner segment
0.47	GO:0001750	photoreceptor outer segment
0.37	GO:0005737	cytoplasm
0.36	GO:0044292	dendrite terminus
0.34	GO:0060170	ciliary membrane
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|O94811|TPPP_HUMAN
Tubulin polymerization-promoting protein
Search

TPPP

0.97	Tubulin polymerization promoting protein p25 alpha

0.81	GO:0001578	microtubule bundle formation
0.79	GO:0046785	microtubule polymerization
0.52	GO:0032273	positive regulation of protein polymerization
0.39	GO:0022900	electron transport chain
0.35	GO:0048675	axon extension

0.73	GO:0015631	tubulin binding
0.39	GO:0020037	heme binding
0.39	GO:0009055	electron transfer activity
0.37	GO:0019706	protein-cysteine S-palmitoyltransferase activity
0.37	GO:0046872	metal ion binding

0.59	GO:0097427	microtubule bundle
0.53	GO:0048471	perinuclear region of cytoplasm
0.52	GO:0043209	myelin sheath
0.50	GO:0005874	microtubule
0.49	GO:0005829	cytosol
0.44	GO:0005634	nucleus
0.44	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

0.37

EC:2.3.1.225

GO:0019706

sp|O94812|BAIP3_HUMAN
BAI1-associated protein 3
Search

BAIAP3

0.96	BAI1-associated protein 3

0.67	GO:0007186	G-protein coupled receptor signaling pathway
0.43	GO:0099643	signal release from synapse
0.43	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.42	GO:0006836	neurotransmitter transport
0.41	GO:0001505	regulation of neurotransmitter levels
0.40	GO:0051649	establishment of localization in cell
0.33	GO:0017156	calcium ion regulated exocytosis
0.33	GO:0097479	synaptic vesicle localization
0.33	GO:0099003	vesicle-mediated transport in synapse
0.33	GO:0140029	exocytic process

0.43

GO:0008022

protein C-terminus binding

0.59	GO:0005783	endoplasmic reticulum
0.42	GO:0098793	presynapse
0.33	GO:0070382	exocytic vesicle
0.30	GO:0016020	membrane

sp|O94813|SLIT2_HUMAN
Slit homolog 2 protein
Search

SLIT2

0.97	Slit guidance ligand 2

0.58	GO:0021952	central nervous system projection neuron axonogenesis
0.57	GO:0090260	negative regulation of retinal ganglion cell axon guidance
0.57	GO:0050929	induction of negative chemotaxis
0.57	GO:0021836	chemorepulsion involved in postnatal olfactory bulb interneuron migration
0.56	GO:0010593	negative regulation of lamellipodium assembly
0.56	GO:0090024	negative regulation of neutrophil chemotaxis
0.56	GO:0071672	negative regulation of smooth muscle cell chemotaxis
0.56	GO:0071504	cellular response to heparin
0.56	GO:0071676	negative regulation of mononuclear cell migration
0.56	GO:0030308	negative regulation of cell growth

0.69	GO:0005509	calcium ion binding
0.56	GO:0043237	laminin-1 binding
0.56	GO:0048495	Roundabout binding
0.55	GO:0005095	GTPase inhibitor activity
0.53	GO:0043394	proteoglycan binding
0.52	GO:0008201	heparin binding
0.49	GO:0042803	protein homodimerization activity
0.38	GO:0045499	chemorepellent activity
0.35	GO:0004963	follicle-stimulating hormone receptor activity

0.61	GO:0005576	extracellular region
0.38	GO:0005737	cytoplasm
0.35	GO:0031982	vesicle
0.35	GO:0009986	cell surface
0.34	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O94817|ATG12_HUMAN
Ubiquitin-like protein ATG12
Search

ATG12

0.77	Ubiquitin-like protein ATG12

0.83	GO:0000045	autophagosome assembly
0.52	GO:0006501	C-terminal protein lipidation
0.51	GO:0044804	autophagy of nucleus
0.51	GO:0000422	autophagy of mitochondrion
0.38	GO:0045087	innate immune response
0.34	GO:0055114	oxidation-reduction process
0.32	GO:0015031	protein transport

0.53	GO:0019776	Atg8 ligase activity
0.37	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
0.36	GO:0005515	protein binding
0.36	GO:0005506	iron ion binding

0.59	GO:0034045	phagophore assembly site membrane
0.55	GO:0005776	autophagosome
0.53	GO:0034274	Atg12-Atg5-Atg16 complex
0.36	GO:0030670	phagocytic vesicle membrane
0.36	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.37

EC:1.13.11

GO:0016702

sp|O94818|NOL4_HUMAN
Nucleolar protein 4
Search

NOL4

0.89	Nucleolar protein 4 like

0.35	GO:0005515	protein binding
0.34	GO:0003723	RNA binding

0.71	GO:0005730	nucleolus
0.44	GO:0005654	nucleoplasm
0.43	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O94819|KBTBB_HUMAN
Kelch repeat and BTB domain-containing protein 11
Search

KBTBD11

0.94	Kelch repeat and BTB domain-containing protein 11

0.68	GO:0016567	protein ubiquitination
0.37	GO:0008584	male gonad development
0.37	GO:0007286	spermatid development
0.37	GO:0009566	fertilization
0.36	GO:0034968	histone lysine methylation
0.34	GO:0045938	positive regulation of circadian sleep/wake cycle, sleep
0.34	GO:0032225	regulation of synaptic transmission, dopaminergic
0.34	GO:0008344	adult locomotory behavior
0.32	GO:0034220	ion transmembrane transport

0.69	GO:0004842	ubiquitin-protein transferase activity
0.36	GO:0018024	histone-lysine N-methyltransferase activity
0.34	GO:0008270	zinc ion binding
0.33	GO:0005216	ion channel activity

0.77	GO:0031463	Cul3-RING ubiquitin ligase complex
0.34	GO:0005634	nucleus
0.33	GO:0005618	cell wall
0.33	GO:0005737	cytoplasm
0.33	GO:0005576	extracellular region
0.30	GO:0016020	membrane

0.36	EC:2.1.1.43	GO:0018024
0.69	KEGG:R03876	GO:0004842

sp|O94822|LTN1_HUMAN
E3 ubiquitin-protein ligase listerin
Search

LTN1

0.88	E3 ubiquitin-protein ligase listerin

0.61	GO:0051865	protein autoubiquitination
0.32	GO:0006351	transcription, DNA-templated
0.31	GO:1903506	regulation of nucleic acid-templated transcription
0.31	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.31	GO:0010468	regulation of gene expression

0.61	GO:0008270	zinc ion binding
0.56	GO:0061630	ubiquitin protein ligase activity
0.50	GO:0016874	ligase activity
0.34	GO:0005515	protein binding
0.31	GO:0003677	DNA binding

0.37	GO:0005680	anaphase-promoting complex
0.30	GO:0031224	intrinsic component of membrane

0.50

GO:0016874

sp|O94823|AT10B_HUMAN
Probable phospholipid-transporting ATPase VB
Search

ATP10B

0.59	Phospholipid-transporting ATPase

0.80	GO:0045332	phospholipid translocation
0.33	GO:0006812	cation transport
0.32	GO:0034220	ion transmembrane transport

0.80	GO:0004012	phospholipid-translocating ATPase activity
0.64	GO:0000287	magnesium ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding

0.56	GO:0005783	endoplasmic reticulum
0.45	GO:0005654	nucleoplasm
0.43	GO:0005886	plasma membrane
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0031984	organelle subcompartment
0.35	GO:0030659	cytoplasmic vesicle membrane
0.30	GO:0031224	intrinsic component of membrane

0.80

EC:3.6.3.1

GO:0004012

sp|O94826|TOM70_HUMAN
Mitochondrial import receptor subunit TOM70
Search

TOMM70

0.92	Translocase of outer mitochondrial membrane 70

0.52	GO:0055015	ventricular cardiac muscle cell development
0.38	GO:0097068	response to thyroxine
0.38	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development
0.36	GO:1904591	positive regulation of protein import
0.36	GO:0016236	macroautophagy
0.36	GO:0006626	protein targeting to mitochondrion
0.35	GO:0071806	protein transmembrane transport
0.33	GO:0006396	RNA processing

0.36	GO:0005515	protein binding
0.35	GO:0008320	protein transmembrane transporter activity

0.50	GO:0005739	mitochondrion
0.40	GO:0031968	organelle outer membrane
0.38	GO:0070062	extracellular exosome
0.36	GO:0031301	integral component of organelle membrane
0.35	GO:0098796	membrane protein complex

sp|O94827|PKHG5_HUMAN
Pleckstrin homology domain-containing family G member 5
Search

PLEKHG5

0.96	Pleckstrin y domain-containing family G member 5

0.76	GO:0035023	regulation of Rho protein signal transduction
0.65	GO:0065009	regulation of molecular function
0.58	GO:0035767	endothelial cell chemotaxis
0.39	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.38	GO:0043534	blood vessel endothelial cell migration
0.37	GO:0007369	gastrulation
0.37	GO:0001525	angiogenesis
0.36	GO:0043065	positive regulation of apoptotic process
0.36	GO:0007165	signal transduction

0.76	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.36	GO:0004871	signal transducer activity

0.55	GO:0030027	lamellipodium
0.54	GO:0030139	endocytic vesicle
0.52	GO:0005911	cell-cell junction
0.42	GO:0005886	plasma membrane
0.40	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0005829	cytosol
0.33	GO:0005813	centrosome
0.30	GO:0016021	integral component of membrane

sp|O94829|IPO13_HUMAN
Importin-13
Search

IPO13

0.92	Putative nuclear transport regulator

0.67	GO:0006886	intracellular protein transport
0.56	GO:0006606	protein import into nucleus
0.33	GO:0006189	'de novo' IMP biosynthetic process

0.78	GO:0008536	Ran GTPase binding
0.48	GO:0008139	nuclear localization sequence binding
0.43	GO:0008565	protein transporter activity
0.35	GO:0035259	glucocorticoid receptor binding
0.34	GO:0004642	phosphoribosylformylglycinamidine synthase activity

0.60	GO:0005634	nucleus
0.42	GO:0012505	endomembrane system
0.40	GO:0031967	organelle envelope
0.40	GO:0031090	organelle membrane
0.37	GO:0005737	cytoplasm
0.35	GO:0042564	NLS-dependent protein nuclear import complex
0.30	GO:0016021	integral component of membrane

0.34	EC:6.3.5.3	GO:0004642
0.34	KEGG:R04463	GO:0004642

sp|O94830|DDHD2_HUMAN
Phospholipase DDHD2
Search

DDHD2

0.94	DDHD domain containing 2

0.70	GO:0090141	positive regulation of mitochondrial fission
0.70	GO:0019433	triglyceride catabolic process
0.69	GO:0034389	lipid particle organization
0.69	GO:0008542	visual learning
0.65	GO:0007626	locomotory behavior
0.51	GO:0006888	ER to Golgi vesicle-mediated transport

0.66	GO:0004806	triglyceride lipase activity
0.54	GO:0046872	metal ion binding
0.51	GO:0004620	phospholipase activity

0.61	GO:0005815	microtubule organizing center
0.56	GO:0005829	cytosol
0.52	GO:0030134	COPII-coated ER to Golgi transport vesicle
0.30	GO:0031224	intrinsic component of membrane

0.66

EC:3.1.1.3

GO:0004806

sp|O94832|MYO1D_HUMAN
Unconventional myosin-Id
Search

MYO1D

0.96	Unconventional myosin-Id

0.74	GO:0007018	microtubule-based movement
0.52	GO:0010923	negative regulation of phosphatase activity
0.45	GO:0051641	cellular localization
0.40	GO:0098927	vesicle-mediated transport between endosomal compartments
0.38	GO:0030900	forebrain development
0.37	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.36	GO:0072678	T cell migration
0.36	GO:0002456	T cell mediated immunity
0.35	GO:0071976	cell gliding
0.34	GO:0031589	cell-substrate adhesion

0.74	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.73	GO:0003779	actin binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0019904	protein domain specific binding
0.41	GO:0030898	actin-dependent ATPase activity
0.39	GO:0005516	calmodulin binding
0.39	GO:0000146	microfilament motor activity

0.77	GO:0016459	myosin complex
0.51	GO:0005903	brush border
0.51	GO:0043209	myelin sheath
0.50	GO:0043025	neuronal cell body
0.50	GO:0030424	axon
0.41	GO:0097440	apical dendrite
0.39	GO:0016323	basolateral plasma membrane
0.39	GO:0031256	leading edge membrane
0.39	GO:0005790	smooth endoplasmic reticulum
0.38	GO:0031410	cytoplasmic vesicle

sp|O94842|TOX4_HUMAN
TOX high mobility group box family member 4
Search

TOX3

0.89	TOX high mobility group box family member 4-A

0.48	GO:0043524	negative regulation of neuron apoptotic process
0.44	GO:0045893	positive regulation of transcription, DNA-templated
0.36	GO:0006915	apoptotic process
0.34	GO:0019722	calcium-mediated signaling
0.33	GO:0006351	transcription, DNA-templated

0.54	GO:0003677	DNA binding
0.48	GO:0051219	phosphoprotein binding
0.45	GO:0003682	chromatin binding
0.45	GO:0001067	regulatory region nucleic acid binding
0.45	GO:0042803	protein homodimerization activity

0.74	GO:0072357	PTW/PP1 phosphatase complex
0.61	GO:0005634	nucleus
0.54	GO:0000781	chromosome, telomeric region
0.51	GO:0000785	chromatin
0.48	GO:0031974	membrane-enclosed lumen

sp|O94844|RHBT1_HUMAN
Rho-related BTB domain-containing protein 1
Search

RHOBTB1

0.97	Rho-related BTB domain-containing protein 1

0.76	GO:0007264	small GTPase mediated signal transduction
0.35	GO:0051056	regulation of small GTPase mediated signal transduction

0.67	GO:0003924	GTPase activity
0.65	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.54	GO:0032553	ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding

0.45	GO:0005622	intracellular
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O94850|DEND_HUMAN
Dendrin
Search

DDN

0.97

Dendrin

0.57

GO:0045944

positive regulation of transcription by RNA polymerase II

0.60	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.59	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.39	GO:0005515	protein binding

0.68	GO:0042995	cell projection
0.61	GO:0005634	nucleus
0.56	GO:0005886	plasma membrane
0.52	GO:0043204	perikaryon
0.50	GO:0031252	cell leading edge
0.49	GO:0098794	postsynapse
0.49	GO:0005737	cytoplasm
0.47	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.45	GO:0031984	organelle subcompartment
0.30	GO:0031224	intrinsic component of membrane

sp|O94851|MICA2_HUMAN
[F-actin]-methionine sulfoxide oxidase MICAL2
Search

MICAL2

0.88	[F-actin]-methionine sulfoxide oxidase MICAL2

0.85	GO:0010735	positive regulation of transcription via serum response element binding
0.82	GO:0030042	actin filament depolymerization
0.52	GO:0055114	oxidation-reduction process
0.45	GO:0001947	heart looping
0.43	GO:0006790	sulfur compound metabolic process

0.86	GO:0043914	NADPH:sulfur oxidoreductase activity
0.72	GO:0003779	actin binding
0.72	GO:0071949	FAD binding
0.52	GO:0046872	metal ion binding
0.46	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

0.60	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.86

GO:0043914

sp|O94854|K0754_HUMAN
Uncharacterized protein KIAA0754
Search

MACF1

0.65	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

0.44	GO:0005509	calcium ion binding
0.39	GO:0008017	microtubule binding
0.39	GO:0003779	actin binding

0.72	GO:0030054	cell junction
0.71	GO:0015629	actin cytoskeleton
0.54	GO:0005886	plasma membrane

sp|O94855|SC24D_HUMAN
Protein transport protein Sec24D
Search

SEC24D

0.91	SEC24 homolog D, COPII coat complex component

0.78	GO:0006888	ER to Golgi vesicle-mediated transport
0.75	GO:0035459	cargo loading into vesicle
0.71	GO:0051668	localization within membrane
0.70	GO:0048194	Golgi vesicle budding
0.69	GO:0006886	intracellular protein transport
0.66	GO:0043009	chordate embryonic development
0.53	GO:0070278	extracellular matrix constituent secretion
0.52	GO:0060536	cartilage morphogenesis
0.50	GO:1904888	cranial skeletal system development
0.49	GO:0048705	skeletal system morphogenesis

0.69	GO:0000149	SNARE binding
0.62	GO:0008270	zinc ion binding

0.80	GO:0030127	COPII vesicle coat
0.63	GO:0000139	Golgi membrane
0.35	GO:0005829	cytosol

sp|O94856|NFASC_HUMAN
Neurofascin
Search

NFASC

0.91	Neurofascin

0.85	GO:0019226	transmission of nerve impulse
0.84	GO:0042552	myelination
0.84	GO:0007422	peripheral nervous system development
0.82	GO:0050808	synapse organization
0.81	GO:0007411	axon guidance
0.68	GO:0002175	protein localization to paranode region of axon
0.66	GO:0045162	clustering of voltage-gated sodium channels
0.66	GO:0071205	protein localization to juxtaparanode region of axon
0.65	GO:0034113	heterotypic cell-cell adhesion
0.62	GO:0007043	cell-cell junction assembly

0.68	GO:0086080	protein binding involved in heterotypic cell-cell adhesion
0.37	GO:0019904	protein domain specific binding

0.67	GO:0033010	paranodal junction
0.66	GO:0043194	axon initial segment
0.65	GO:0033270	paranode region of axon
0.61	GO:0043209	myelin sheath
0.46	GO:0005886	plasma membrane
0.40	GO:0097454	Schwann cell microvillus
0.39	GO:0101003	ficolin-1-rich granule membrane
0.39	GO:0033268	node of Ranvier
0.37	GO:0005925	focal adhesion
0.37	GO:0070062	extracellular exosome

sp|O94864|ST65G_HUMAN
STAGA complex 65 subunit gamma
Search

SUPT7L

0.97	STAGA complex 65 subunit gamma

0.60	GO:0051457	maintenance of protein location in nucleus
0.58	GO:0043966	histone H3 acetylation
0.44	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:0006351	transcription, DNA-templated
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression

0.72	GO:0046982	protein heterodimerization activity
0.56	GO:0004402	histone acetyltransferase activity
0.55	GO:0003713	transcription coactivator activity

0.60

GO:0030914

STAGA complex

0.56

GO:0004402

sp|O94868|FCSD2_HUMAN
F-BAR and double SH3 domains protein 2
Search

FCHSD2

0.95	F-BAR and double SH3 domains protein 2

0.85	GO:0007274	neuromuscular synaptic transmission
0.78	GO:0030833	regulation of actin filament polymerization

0.40

GO:0005515

protein binding

0.85	GO:0031594	neuromuscular junction
0.83	GO:0055037	recycling endosome

sp|O94874|UFL1_HUMAN
E3 UFM1-protein ligase 1
Search

UFL1

0.94	UFM1 specific ligase 1

0.65	GO:0071569	protein ufmylation
0.63	GO:1902065	response to L-glutamate
0.63	GO:0033146	regulation of intracellular estrogen receptor signaling pathway
0.62	GO:0032088	negative regulation of NF-kappaB transcription factor activity
0.62	GO:0060252	positive regulation of glial cell proliferation
0.61	GO:0031397	negative regulation of protein ubiquitination
0.60	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
0.58	GO:0034976	response to endoplasmic reticulum stress
0.55	GO:0032880	regulation of protein localization
0.39	GO:0043066	negative regulation of apoptotic process

0.67	GO:0071568	UFM1 transferase activity
0.56	GO:0016874	ligase activity
0.35	GO:0005515	protein binding

0.55	GO:0043005	neuron projection
0.53	GO:0005783	endoplasmic reticulum
0.53	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.51	GO:0031984	organelle subcompartment
0.47	GO:0043234	protein complex
0.39	GO:0005829	cytosol
0.30	GO:0044425	membrane part

0.56

GO:0016874

sp|O94875|SRBS2_HUMAN
Sorbin and SH3 domain-containing protein 2
Search

SORBS2

0.94	Sorbin and SH3 domain-containing protein 2

0.74	GO:0007015	actin filament organization
0.41	GO:0061049	cell growth involved in cardiac muscle cell development
0.38	GO:0007219	Notch signaling pathway

0.44	GO:0003676	nucleic acid binding
0.38	GO:0019904	protein domain specific binding
0.37	GO:0008307	structural constituent of muscle
0.37	GO:0008093	cytoskeletal adaptor activity
0.36	GO:0005200	structural constituent of cytoskeleton
0.32	GO:0046872	metal ion binding

0.49	GO:0005654	nucleoplasm
0.41	GO:0030027	lamellipodium
0.40	GO:0005925	focal adhesion
0.40	GO:0016324	apical plasma membrane
0.40	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0030018	Z disc
0.37	GO:0005856	cytoskeleton
0.36	GO:0014069	postsynaptic density
0.36	GO:0043025	neuronal cell body
0.36	GO:0030425	dendrite

sp|O94876|TMCC1_HUMAN
Transmembrane and coiled-coil domains protein 1
Search

TMCC1

0.93	LOW QUALITY PROTEIN: transmembrane and coiled-coil domains protein 1

0.55	GO:0051291	protein heterooligomerization
0.54	GO:0007029	endoplasmic reticulum organization
0.52	GO:0051260	protein homooligomerization
0.34	GO:0071526	semaphorin-plexin signaling pathway
0.33	GO:0006468	protein phosphorylation

0.50	GO:0042803	protein homodimerization activity
0.50	GO:0046982	protein heterodimerization activity
0.34	GO:0017154	semaphorin receptor activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.54	GO:0005791	rough endoplasmic reticulum
0.47	GO:0005829	cytosol
0.36	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O94880|PHF14_HUMAN
PHD finger protein 14
Search

PHF14

0.93	PHD finger protein 14

0.57	GO:2000584	negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
0.57	GO:2000791	negative regulation of mesenchymal cell proliferation involved in lung development
0.54	GO:0048286	lung alveolus development
0.50	GO:0000122	negative regulation of transcription by RNA polymerase II

0.54

GO:0046872

metal ion binding

0.43	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|O94885|SASH1_HUMAN
SAM and SH3 domain-containing protein 1
Search

SASH1

0.97	SAM and SH3 domain-containing protein 1

0.87	GO:1902498	regulation of protein autoubiquitination
0.87	GO:1900044	regulation of protein K63-linked ubiquitination
0.87	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
0.86	GO:1900745	positive regulation of p38MAPK cascade
0.85	GO:1901224	positive regulation of NIK/NF-kappaB signaling
0.85	GO:0043507	positive regulation of JUN kinase activity
0.85	GO:0010595	positive regulation of endothelial cell migration
0.84	GO:0045766	positive regulation of angiogenesis
0.82	GO:0000209	protein polyubiquitination

0.86	GO:0031435	mitogen-activated protein kinase kinase kinase binding
0.83	GO:0008022	protein C-terminus binding
0.81	GO:0032947	protein complex scaffold activity

0.60	GO:0043234	protein complex
0.30	GO:0016020	membrane

sp|O94886|CSCL1_HUMAN
CSC1-like protein 1
Search

TMEM63A

0.97	Transmembrane protein 63A

0.50

GO:0003676

nucleic acid binding

0.57	GO:0005765	lysosomal membrane
0.54	GO:0005815	microtubule organizing center
0.38	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

sp|O94887|FARP2_HUMAN
FERM, RhoGEF and pleckstrin domain-containing protein 2
Search

FARP2

0.97	FERM, ARHGEF and pleckstrin domain-containing protein 2

0.75	GO:0035023	regulation of Rho protein signal transduction
0.64	GO:0065009	regulation of molecular function
0.59	GO:0033623	regulation of integrin activation
0.59	GO:0071800	podosome assembly
0.59	GO:0016601	Rac protein signal transduction
0.58	GO:0016322	neuron remodeling
0.57	GO:0030316	osteoclast differentiation
0.55	GO:0071526	semaphorin-plexin signaling pathway
0.54	GO:0022405	hair cycle process
0.52	GO:0031532	actin cytoskeleton reorganization

0.76	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.60	GO:0008092	cytoskeletal protein binding
0.57	GO:0048365	Rac GTPase binding

0.67	GO:0005856	cytoskeleton
0.39	GO:0005737	cytoplasm

sp|O94888|UBXN7_HUMAN
UBX domain-containing protein 7
Search

UBXN7

0.96	UBX domain-containing protein 7

0.40

GO:0043687

post-translational protein modification

0.80	GO:0043130	ubiquitin binding
0.78	GO:0031625	ubiquitin protein ligase binding
0.71	GO:0008134	transcription factor binding

0.85	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex
0.76	GO:0016604	nuclear body
0.37	GO:0005829	cytosol

sp|O94889|KLH18_HUMAN
Kelch-like protein 18
Search

0.48	Kelch like family member 18

0.73

GO:0016567

protein ubiquitination

0.74	GO:0004842	ubiquitin-protein transferase activity
0.39	GO:0005515	protein binding

0.83

GO:0031463

Cul3-RING ubiquitin ligase complex

0.74

GO:0004842

sp|O94892|ZN432_HUMAN
Zinc finger protein 432
Search

ZNF432

0.70	Zinc finger protein 432

0.54	GO:1903506	regulation of nucleic acid-templated transcription
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.36	GO:1902679	negative regulation of RNA biosynthetic process
0.35	GO:1902680	positive regulation of RNA biosynthetic process
0.33	GO:1902600	hydrogen ion transmembrane transport
0.33	GO:0022900	electron transport chain
0.30	GO:0044238	primary metabolic process
0.30	GO:0018130	heterocycle biosynthetic process
0.30	GO:1901362	organic cyclic compound biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.51	GO:0046872	metal ion binding
0.41	GO:0003700	DNA binding transcription factor activity
0.35	GO:0003682	chromatin binding
0.34	GO:0015002	heme-copper terminal oxidase activity
0.34	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.33	GO:0015078	hydrogen ion transmembrane transporter activity
0.33	GO:0009055	electron transfer activity

0.43	GO:0005622	intracellular
0.41	GO:0031974	membrane-enclosed lumen
0.39	GO:0044422	organelle part
0.38	GO:0043227	membrane-bounded organelle
0.33	GO:0070469	respiratory chain
0.33	GO:0031975	envelope
0.33	GO:0017053	transcriptional repressor complex
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0016676

sp|O94898|LRIG2_HUMAN
Leucine-rich repeats and immunoglobulin-like domains protein 2
Search

LRIG2

0.93	Leucine rich repeats and immunoglobulin like domains 2

0.61	GO:0051045	negative regulation of membrane protein ectodomain proteolysis
0.61	GO:0060384	innervation
0.60	GO:2000010	positive regulation of protein localization to cell surface
0.60	GO:0010640	regulation of platelet-derived growth factor receptor signaling pathway
0.60	GO:0048681	negative regulation of axon regeneration
0.59	GO:2001222	regulation of neuron migration
0.57	GO:0007605	sensory perception of sound
0.55	GO:0032474	otolith morphogenesis

0.51

GO:0005102

receptor binding

0.58	GO:0030426	growth cone
0.56	GO:0043025	neuronal cell body
0.52	GO:0097708	intracellular vesicle
0.35	GO:0012506	vesicle membrane
0.35	GO:0005615	extracellular space
0.35	GO:0005886	plasma membrane
0.34	GO:0005737	cytoplasm
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

sp|O94900|TOX_HUMAN
Thymocyte selection-associated high mobility group box protein TOX
Search

TOX

0.97	Thymocyte selection-associated high mobility group box protein TOX

0.36	GO:0043524	negative regulation of neuron apoptotic process
0.35	GO:0045893	positive regulation of transcription, DNA-templated

0.54	GO:0003677	DNA binding
0.36	GO:0051219	phosphoprotein binding
0.36	GO:0003682	chromatin binding
0.35	GO:0001067	regulatory region nucleic acid binding
0.35	GO:0042803	protein homodimerization activity

0.60

GO:0005634

nucleus

sp|O94901|SUN1_HUMAN
SUN domain-containing protein 1
Search

SUN1

0.74	Sad1 and UNC84 domain containing 1

0.68	GO:0021817	nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
0.68	GO:0090292	nuclear matrix anchoring at nuclear membrane
0.67	GO:0090286	cytoskeletal anchoring at nuclear membrane
0.66	GO:0006998	nuclear envelope organization
0.65	GO:0070197	meiotic attachment of telomere to nuclear envelope
0.64	GO:0051642	centrosome localization
0.62	GO:0007129	synapsis
0.45	GO:0009612	response to mechanical stimulus
0.45	GO:0001503	ossification

0.65	GO:0005521	lamin binding
0.55	GO:0043495	protein membrane anchor

0.84	GO:0106094	nuclear membrane microtubule tethering complex
0.84	GO:0034992	microtubule organizing center attachment site
0.84	GO:0031229	intrinsic component of nuclear inner membrane
0.77	GO:0031301	integral component of organelle membrane
0.65	GO:0002080	acrosomal membrane
0.42	GO:0005730	nucleolus

sp|O94903|PROSC_HUMAN
Proline synthase co-transcribed bacterial homolog protein
Search

PROSC

0.67	Proline synthase co-transcribed bacterial protein (Fragment)

0.67

GO:0030170

pyridoxal phosphate binding

0.36	GO:0005739	mitochondrion
0.30	GO:0070062	extracellular exosome

sp|O94905|ERLN2_HUMAN
Erlin-2
Search

ERLIN2

0.97	Endoplasmic reticulum lipid raft-associated protein 2

0.82	GO:0030433	ubiquitin-dependent ERAD pathway
0.63	GO:0045541	negative regulation of cholesterol biosynthetic process
0.62	GO:0032933	SREBP signaling pathway
0.59	GO:0045717	negative regulation of fatty acid biosynthetic process
0.45	GO:0008203	cholesterol metabolic process
0.34	GO:0018108	peptidyl-tyrosine phosphorylation
0.33	GO:0055085	transmembrane transport

0.79	GO:0031625	ubiquitin protein ligase binding
0.54	GO:0015485	cholesterol binding
0.34	GO:0004713	protein tyrosine kinase activity
0.33	GO:0008233	peptidase activity
0.33	GO:0070279	vitamin B6 binding
0.32	GO:0050662	coenzyme binding
0.32	GO:0043168	anion binding

0.70	GO:0005783	endoplasmic reticulum
0.54	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.53	GO:0045121	membrane raft
0.52	GO:0031984	organelle subcompartment
0.48	GO:0005829	cytosol
0.46	GO:0043234	protein complex
0.42	GO:0005886	plasma membrane
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0004713

sp|O94906|PRP6_HUMAN
Pre-mRNA-processing factor 6
Search

PRPF6

0.93	Pre-mRNA processing factor 6

0.75	GO:0000398	mRNA splicing, via spliceosome
0.52	GO:0022618	ribonucleoprotein complex assembly
0.49	GO:0045944	positive regulation of transcription by RNA polymerase II
0.49	GO:0006403	RNA localization

0.55	GO:0050681	androgen receptor binding
0.51	GO:0003713	transcription coactivator activity
0.49	GO:0043021	ribonucleoprotein complex binding
0.43	GO:0003723	RNA binding

0.61	GO:0005634	nucleus
0.54	GO:0120114	Sm-like protein family complex
0.46	GO:0031974	membrane-enclosed lumen
0.46	GO:1902494	catalytic complex
0.46	GO:0030529	intracellular ribonucleoprotein complex
0.44	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|O94907|DKK1_HUMAN
Dickkopf-related protein 1
Search

DKK1

0.94	Dickkopf WNT signaling pathway inhibitor 1

0.80	GO:0030178	negative regulation of Wnt signaling pathway
0.68	GO:0007275	multicellular organism development
0.65	GO:1904711	regulation of Wnt-Frizzled-LRP5/6 complex assembly
0.64	GO:0060828	regulation of canonical Wnt signaling pathway
0.63	GO:0003307	regulation of Wnt signaling pathway involved in heart development
0.63	GO:0042662	negative regulation of mesodermal cell fate specification
0.63	GO:0042663	regulation of endodermal cell fate specification
0.62	GO:2000726	negative regulation of cardiac muscle cell differentiation
0.62	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
0.61	GO:1901321	positive regulation of heart induction

0.68	GO:0039706	co-receptor binding
0.61	GO:0048019	receptor antagonist activity
0.60	GO:0050750	low-density lipoprotein particle receptor binding
0.35	GO:0008083	growth factor activity
0.35	GO:0004692	cGMP-dependent protein kinase activity
0.34	GO:0004871	signal transducer activity
0.33	GO:0004190	aspartic-type endopeptidase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0008144	drug binding

0.65	GO:0005576	extracellular region
0.44	GO:0005886	plasma membrane
0.36	GO:0031901	early endosome membrane
0.30	GO:0016021	integral component of membrane

0.35

EC:2.7.11.12

GO:0004692

sp|O94910|AGRL1_HUMAN
Adhesion G protein-coupled receptor L1
Search

ADGRL1

0.89	Adhesion G protein-coupled receptor L1

0.71	GO:0007166	cell surface receptor signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.53	GO:0051965	positive regulation of synapse assembly
0.41	GO:0090129	positive regulation of synapse maturation
0.40	GO:0035584	calcium-mediated signaling using intracellular calcium source
0.40	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
0.35	GO:0016079	synaptic vesicle exocytosis
0.34	GO:0007420	brain development

0.72	GO:0004930	G-protein coupled receptor activity
0.68	GO:0030246	carbohydrate binding
0.42	GO:0016524	latrotoxin receptor activity
0.39	GO:0050839	cell adhesion molecule binding
0.35	GO:0015643	toxic substance binding

0.40	GO:0042734	presynaptic membrane
0.40	GO:0030426	growth cone
0.39	GO:0030424	axon
0.38	GO:0030054	cell junction
0.35	GO:0014069	postsynaptic density
0.33	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

sp|O94911|ABCA8_HUMAN
ATP-binding cassette sub-family A member 8
Search

0.73	ATP-binding cassette sub-family A member 8

0.56	GO:0006869	lipid transport
0.55	GO:0055085	transmembrane transport
0.43	GO:0042908	xenobiotic transport
0.41	GO:0015893	drug transport

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0042910	xenobiotic transmembrane transporter activity
0.41	GO:0015238	drug transmembrane transporter activity

0.44	GO:0043231	intracellular membrane-bounded organelle
0.43	GO:0044446	intracellular organelle part
0.43	GO:0031090	organelle membrane
0.42	GO:0031975	envelope
0.40	GO:0044444	cytoplasmic part
0.40	GO:0031974	membrane-enclosed lumen
0.37	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O94913|PCF11_HUMAN
Pre-mRNA cleavage complex 2 protein Pcf11
Search

PCF11

0.90	Cleavage and polyadenylation factor subunit homolog (S. cerevisiae)

0.65	GO:0006369	termination of RNA polymerase II transcription
0.63	GO:0006379	mRNA cleavage
0.62	GO:0006378	mRNA polyadenylation
0.40	GO:0000398	mRNA splicing, via spliceosome
0.35	GO:0006886	intracellular protein transport

0.63	GO:0000993	RNA polymerase II core binding
0.57	GO:0003729	mRNA binding

0.70	GO:0005654	nucleoplasm
0.59	GO:0005739	mitochondrion
0.49	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

sp|O94915|FRYL_HUMAN
Protein furry homolog-like
Search

FRYL

0.97	FRY like transcription coactivator

0.71	GO:0031175	neuron projection development
0.70	GO:0090527	actin filament reorganization
0.68	GO:0000902	cell morphogenesis
0.58	GO:0007507	heart development
0.37	GO:0006351	transcription, DNA-templated
0.36	GO:1903506	regulation of nucleic acid-templated transcription
0.36	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.36	GO:0010468	regulation of gene expression

0.73	GO:0030427	site of polarized growth
0.69	GO:0005938	cell cortex
0.30	GO:0016020	membrane

sp|O94916|NFAT5_HUMAN
Nuclear factor of activated T-cells 5
Search

NFAT5

0.95	Tonicity-responsive enhancer binding protein TonEBP

0.76	GO:0006366	transcription by RNA polymerase II
0.62	GO:0070884	regulation of calcineurin-NFAT signaling cascade
0.59	GO:0001816	cytokine production
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:0051254	positive regulation of RNA metabolic process
0.53	GO:0010557	positive regulation of macromolecule biosynthetic process
0.53	GO:0031328	positive regulation of cellular biosynthetic process
0.37	GO:0006970	response to osmotic stress

0.80	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.34	GO:0005515	protein binding
0.33	GO:0020037	heme binding
0.32	GO:0016491	oxidoreductase activity
0.32	GO:0046872	metal ion binding
0.32	GO:0016301	kinase activity

0.52	GO:0005654	nucleoplasm
0.51	GO:0005829	cytosol

0.32

GO:0016491

sp|O94919|ENDD1_HUMAN
Endonuclease domain-containing 1 protein
Search

ENDOD1

0.93	Endonuclease domain containing 1

0.53	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.39	GO:0002576	platelet degranulation

0.54	GO:0004519	endonuclease activity
0.52	GO:0046872	metal ion binding
0.49	GO:0003676	nucleic acid binding

0.39	GO:0070062	extracellular exosome
0.36	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O94921|CDK14_HUMAN
Cyclin-dependent kinase 14
Search

CDK14

0.96	Serine/threonine-protein kinase PFTAIRE-1 (Predicted)

0.60	GO:0006468	protein phosphorylation
0.55	GO:0000086	G2/M transition of mitotic cell cycle
0.54	GO:0060828	regulation of canonical Wnt signaling pathway
0.50	GO:0051726	regulation of cell cycle
0.42	GO:0016055	Wnt signaling pathway
0.40	GO:0051301	cell division

0.65	GO:0004674	protein serine/threonine kinase activity
0.56	GO:0097472	cyclin-dependent protein kinase activity
0.53	GO:0030332	cyclin binding
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0020037	heme binding

0.59	GO:0000308	cytoplasmic cyclin-dependent protein kinase holoenzyme complex
0.47	GO:0005829	cytosol
0.45	GO:0005634	nucleus
0.42	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.65

GO:0004674

sp|O94923|GLCE_HUMAN
D-glucuronyl C5-epimerase
Search

GLCE

0.92	Glucuronic acid epimerase a

0.69	GO:0006024	glycosaminoglycan biosynthetic process
0.61	GO:0030202	heparin metabolic process
0.60	GO:0030201	heparan sulfate proteoglycan metabolic process
0.58	GO:0030166	proteoglycan biosynthetic process
0.48	GO:0044272	sulfur compound biosynthetic process
0.37	GO:0009950	dorsal/ventral axis specification

0.72

GO:0016857

racemase and epimerase activity, acting on carbohydrates and derivatives

0.51	GO:0005794	Golgi apparatus
0.37	GO:0098588	bounding membrane of organelle
0.37	GO:0031984	organelle subcompartment
0.30	GO:0031224	intrinsic component of membrane

0.72

EC:5.1.3

GO:0016857

sp|O94925|GLSK_HUMAN
Glutaminase kidney isoform, mitochondrial
Search

GLS

0.49	Glutaminase kidney

0.71	GO:0006541	glutamine metabolic process
0.55	GO:0001967	suckling behavior
0.55	GO:0002087	regulation of respiratory gaseous exchange by neurological system process
0.53	GO:0051289	protein homotetramerization
0.52	GO:0006537	glutamate biosynthetic process
0.51	GO:0009065	glutamine family amino acid catabolic process
0.50	GO:0007268	chemical synaptic transmission
0.36	GO:0014047	glutamate secretion

0.79	GO:0004359	glutaminase activity
0.36	GO:0042802	identical protein binding

0.45	GO:0005759	mitochondrial matrix
0.36	GO:0005829	cytosol

0.79

EC:3.5.1.2

GO:0004359

sp|O94927|HAUS5_HUMAN
HAUS augmin-like complex subunit 5
Search

HAUS5

0.96	HAUS augmin like complex subunit 5

0.82	GO:0007098	centrosome cycle
0.82	GO:0051225	spindle assembly
0.40	GO:0097711	ciliary basal body-plasma membrane docking
0.39	GO:0000086	G2/M transition of mitotic cell cycle
0.39	GO:0010389	regulation of G2/M transition of mitotic cell cycle
0.38	GO:0051301	cell division
0.36	GO:0009607	response to biotic stimulus

0.35	GO:0005515	protein binding
0.35	GO:0003723	RNA binding

0.84	GO:0070652	HAUS complex
0.63	GO:0005813	centrosome
0.40	GO:0005819	spindle
0.39	GO:0005874	microtubule
0.36	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O94929|ABLM3_HUMAN
Actin-binding LIM protein 3
Search

ABLIM3

0.95	Actin-binding LIM protein 3

0.74	GO:0030036	actin cytoskeleton organization
0.62	GO:0030032	lamellipodium assembly
0.60	GO:1903955	positive regulation of protein targeting to mitochondrion
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:0060271	cilium assembly
0.54	GO:0045944	positive regulation of transcription by RNA polymerase II

0.74	GO:0003779	actin binding
0.53	GO:0046872	metal ion binding

0.60	GO:0097517	contractile actin filament bundle
0.60	GO:0042641	actomyosin
0.59	GO:0030027	lamellipodium
0.33	GO:0005737	cytoplasm

sp|O94933|SLIK3_HUMAN
SLIT and NTRK-like protein 3
Search

SLITRK3

0.94	SLIT and NTRK like family member 3

0.64	GO:0051965	positive regulation of synapse assembly
0.62	GO:0007409	axonogenesis
0.39	GO:0007625	grooming behavior
0.39	GO:0021756	striatum development
0.38	GO:0048813	dendrite morphogenesis
0.38	GO:0043588	skin development
0.38	GO:0030534	adult behavior
0.38	GO:0072358	cardiovascular system development
0.37	GO:0007268	chemical synaptic transmission
0.37	GO:0009410	response to xenobiotic stimulus

0.32	GO:0005515	protein binding
0.32	GO:0003677	DNA binding

0.40	GO:0043235	receptor complex
0.34	GO:0005886	plasma membrane
0.32	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

sp|O94941|RNF37_HUMAN
RING finger protein 37
Search

UBOX5

0.92	RING finger protein 37

0.73	GO:0016567	protein ubiquitination
0.36	GO:0010469	regulation of receptor activity

0.74	GO:0004842	ubiquitin-protein transferase activity
0.50	GO:0031625	ubiquitin protein ligase binding
0.49	GO:0061659	ubiquitin-like protein ligase activity
0.37	GO:0005185	neurohypophyseal hormone activity
0.36	GO:0046872	metal ion binding

0.51	GO:0005925	focal adhesion
0.50	GO:0016604	nuclear body
0.35	GO:0005576	extracellular region

0.74

GO:0004842

sp|O94952|FBX21_HUMAN
F-box only protein 21
Search

FBXO21

0.92	F-box only protein 21

0.37	GO:0016567	protein ubiquitination
0.35	GO:0043687	post-translational protein modification
0.35	GO:0006511	ubiquitin-dependent protein catabolic process

0.54	GO:0003677	DNA binding
0.37	GO:0004842	ubiquitin-protein transferase activity
0.35	GO:0005509	calcium ion binding

0.35	GO:0000151	ubiquitin ligase complex
0.34	GO:0005829	cytosol

0.37

GO:0004842

sp|O94953|KDM4B_HUMAN
Lysine-specific demethylase 4B
Search

KDM4B

0.92	Lysine-specific demethylase 4B

0.58	GO:1900113	negative regulation of histone H3-K9 trimethylation
0.58	GO:0070544	histone H3-K36 demethylation
0.58	GO:0033169	histone H3-K9 demethylation
0.54	GO:0032259	methylation
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0010468	regulation of gene expression
0.34	GO:0055114	oxidation-reduction process

0.58	GO:0032454	histone demethylase activity (H3-K9 specific)
0.54	GO:0008168	methyltransferase activity
0.53	GO:0046872	metal ion binding
0.46	GO:0051864	histone demethylase activity (H3-K36 specific)

0.59	GO:0005634	nucleus
0.55	GO:0005721	pericentric heterochromatin
0.48	GO:0031974	membrane-enclosed lumen
0.47	GO:0005829	cytosol

0.54

GO:0008168

sp|O94955|RHBT3_HUMAN
Rho-related BTB domain-containing protein 3
Search

RHOBTB3

0.97	Rho-related BTB domain-containing protein 3

0.68	GO:0016192	vesicle-mediated transport
0.60	GO:0008584	male gonad development
0.58	GO:0016482	cytosolic transport
0.57	GO:0016197	endosomal transport
0.37	GO:0042128	nitrate assimilation
0.36	GO:0007264	small GTPase mediated signal transduction
0.34	GO:0055114	oxidation-reduction process
0.34	GO:0045454	cell redox homeostasis
0.33	GO:0006091	generation of precursor metabolites and energy

0.80	GO:0017137	Rab GTPase binding
0.63	GO:0003924	GTPase activity
0.60	GO:0032550	purine ribonucleoside binding
0.60	GO:0016887	ATPase activity
0.60	GO:0019001	guanyl nucleotide binding
0.51	GO:0032555	purine ribonucleotide binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0030554	adenyl nucleotide binding
0.44	GO:0008144	drug binding
0.37	GO:0008942	nitrite reductase [NAD(P)H] activity

0.52	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.36	GO:0005794	Golgi apparatus
0.34	GO:0098588	bounding membrane of organelle
0.34	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.60	EC:3.6.1.3	GO:0016887
0.37	KEGG:R00787 KEGG:R00789	GO:0008942

sp|O94956|SO2B1_HUMAN
Solute carrier organic anion transporter family member 2B1
Search

SLCO2B1

0.61	Solute carrier organic anion transporter family member

0.58	GO:0006811	ion transport
0.55	GO:0055085	transmembrane transport
0.48	GO:0015850	organic hydroxy compound transport
0.47	GO:0006869	lipid transport
0.45	GO:0015849	organic acid transport
0.40	GO:0001889	liver development
0.39	GO:1901571	fatty acid derivative transport

0.56	GO:0005215	transporter activity
0.39	GO:0008270	zinc ion binding

0.55	GO:0005886	plasma membrane
0.39	GO:0045177	apical part of cell
0.36	GO:0045178	basal part of cell
0.30	GO:0016021	integral component of membrane

sp|O94964|SOGA1_HUMAN
Protein SOGA1
Search

SOGA1

0.94	Microtubule crosslinking factor 1

0.74	GO:0010506	regulation of autophagy
0.52	GO:0008286	insulin receptor signaling pathway
0.42	GO:0045721	negative regulation of gluconeogenesis
0.37	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
0.37	GO:0001578	microtubule bundle formation
0.33	GO:2000576	positive regulation of microtubule motor activity
0.33	GO:0090314	positive regulation of protein targeting to membrane
0.30	GO:0008152	metabolic process

0.38	GO:0008017	microtubule binding
0.34	GO:0042803	protein homodimerization activity
0.30	GO:0003824	catalytic activity

0.73	GO:0005615	extracellular space
0.40	GO:0030496	midbody
0.39	GO:0000922	spindle pole
0.39	GO:1903561	extracellular vesicle
0.38	GO:0097427	microtubule bundle
0.38	GO:0016327	apicolateral plasma membrane
0.37	GO:0016328	lateral plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O94966|UBP19_HUMAN
Ubiquitin carboxyl-terminal hydrolase 19
Search

USP19

0.72	Ubiquitin carboxyl-terminal hydrolase 19

0.76	GO:0016579	protein deubiquitination
0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.54	GO:1900037	regulation of cellular response to hypoxia
0.54	GO:0048642	negative regulation of skeletal muscle tissue development
0.53	GO:1904292	regulation of ERAD pathway
0.53	GO:1901799	negative regulation of proteasomal protein catabolic process
0.51	GO:0036503	ERAD pathway
0.50	GO:0050821	protein stabilization
0.42	GO:0021551	central nervous system morphogenesis
0.41	GO:0090068	positive regulation of cell cycle process

0.77	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.53	GO:0051879	Hsp90 protein binding
0.52	GO:1990380	Lys48-specific deubiquitinase activity
0.50	GO:0031625	ubiquitin protein ligase binding
0.35	GO:0046872	metal ion binding

0.47	GO:0005789	endoplasmic reticulum membrane
0.45	GO:0005829	cytosol
0.39	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.77

GO:0036459

sp|O94967|WDR47_HUMAN
WD repeat-containing protein 47
Search

WDR47

0.95	WD repeat-containing protein 47

0.58	GO:0007275	multicellular organism development
0.53	GO:0120036	plasma membrane bounded cell projection organization
0.52	GO:0048468	cell development
0.47	GO:0006366	transcription by RNA polymerase II

0.58	GO:0030507	spectrin binding
0.55	GO:0005516	calmodulin binding
0.52	GO:0008017	microtubule binding
0.46	GO:0046982	protein heterodimerization activity

0.61	GO:0005874	microtubule
0.40	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O94972|TRI37_HUMAN
E3 ubiquitin-protein ligase TRIM37
Search

TRIM37

0.91	Tripartite motif-containing 37

0.72	GO:0016567	protein ubiquitination
0.71	GO:0070842	aggresome assembly
0.68	GO:0046600	negative regulation of centriole replication
0.66	GO:0032088	negative regulation of NF-kappaB transcription factor activity
0.65	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.61	GO:0000122	negative regulation of transcription by RNA polymerase II
0.59	GO:0016570	histone modification
0.38	GO:0006898	receptor-mediated endocytosis

0.65	GO:0005164	tumor necrosis factor receptor binding
0.63	GO:0008270	zinc ion binding
0.62	GO:0031625	ubiquitin protein ligase binding
0.61	GO:0003682	chromatin binding
0.60	GO:0061630	ubiquitin protein ligase activity
0.60	GO:0042803	protein homodimerization activity
0.40	GO:0005044	scavenger receptor activity

0.67	GO:0016235	aggresome
0.66	GO:0035098	ESC/E(Z) complex
0.60	GO:0005777	peroxisome
0.55	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O94973|AP2A2_HUMAN
AP-2 complex subunit alpha-2
Search

AP2A2

0.69	AP-2 complex subunit alpha

0.71	GO:0072583	clathrin-dependent endocytosis
0.69	GO:0006886	intracellular protein transport
0.38	GO:0060218	hematopoietic stem cell differentiation
0.38	GO:0009950	dorsal/ventral axis specification
0.36	GO:0032802	low-density lipoprotein particle receptor catabolic process
0.35	GO:2000026	regulation of multicellular organismal development
0.35	GO:0034383	low-density lipoprotein particle clearance
0.35	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.35	GO:0043312	neutrophil degranulation
0.35	GO:0035567	non-canonical Wnt signaling pathway

0.84	GO:0035615	clathrin adaptor activity
0.64	GO:0008565	protein transporter activity
0.52	GO:0097718	disordered domain specific binding
0.49	GO:0019901	protein kinase binding
0.37	GO:0008289	lipid binding
0.34	GO:0032403	protein complex binding
0.32	GO:0043168	anion binding

0.78	GO:0030131	clathrin adaptor complex
0.73	GO:0005905	clathrin-coated pit
0.47	GO:0031410	cytoplasmic vesicle
0.40	GO:0005794	Golgi apparatus
0.37	GO:0012506	vesicle membrane
0.36	GO:0098588	bounding membrane of organelle
0.35	GO:0098797	plasma membrane protein complex
0.34	GO:0005764	lysosome
0.34	GO:0098793	presynapse
0.34	GO:0044446	intracellular organelle part

sp|O94979|SC31A_HUMAN
Protein transport protein Sec31A
Search

SEC31A

0.92	SEC31 homolog A, COPII coat complex component

0.84	GO:0090110	cargo loading into COPII-coated vesicle
0.80	GO:0051592	response to calcium ion
0.43	GO:0015031	protein transport
0.43	GO:0036498	IRE1-mediated unfolded protein response
0.42	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.41	GO:0048208	COPII vesicle coating
0.41	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I

0.82

GO:0048306

calcium-dependent protein binding

0.84	GO:0070971	endoplasmic reticulum exit site
0.77	GO:0030134	COPII-coated ER to Golgi transport vesicle
0.75	GO:0030658	transport vesicle membrane
0.75	GO:0048471	perinuclear region of cytoplasm
0.74	GO:0030120	vesicle coat
0.74	GO:0030660	Golgi-associated vesicle membrane
0.70	GO:0000139	Golgi membrane
0.67	GO:0005829	cytosol
0.46	GO:0005789	endoplasmic reticulum membrane
0.38	GO:0005768	endosome

sp|O94983|CMTA2_HUMAN
Calmodulin-binding transcription activator 2
Search

CAMTA2

0.95	Calmodulin-binding transcription activator 2

0.59	GO:0003299	muscle hypertrophy in response to stress
0.58	GO:0014887	cardiac muscle adaptation
0.58	GO:0003300	cardiac muscle hypertrophy
0.53	GO:0045944	positive regulation of transcription by RNA polymerase II
0.45	GO:0006366	transcription by RNA polymerase II
0.35	GO:0050885	neuromuscular process controlling balance
0.32	GO:0016192	vesicle-mediated transport

0.56	GO:0042826	histone deacetylase binding
0.54	GO:0003677	DNA binding
0.52	GO:0003682	chromatin binding
0.50	GO:0008134	transcription factor binding
0.47	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding

0.60	GO:0005634	nucleus
0.36	GO:0097197	tetraspanin-enriched microdomain
0.35	GO:0001772	immunological synapse
0.35	GO:0005829	cytosol
0.35	GO:0043233	organelle lumen
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.34	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

sp|O94985|CSTN1_HUMAN
Calsyntenin-1
Search

CLSTN1

0.95	Calsyntenin-1

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.54	GO:0001558	regulation of cell growth
0.54	GO:0051965	positive regulation of synapse assembly
0.53	GO:0050806	positive regulation of synaptic transmission
0.45	GO:1990126	retrograde transport, endosome to plasma membrane
0.43	GO:0050770	regulation of axonogenesis
0.43	GO:0008361	regulation of cell size
0.42	GO:0048638	regulation of developmental growth
0.34	GO:0006874	cellular calcium ion homeostasis
0.34	GO:0007268	chemical synaptic transmission

0.70	GO:0005509	calcium ion binding
0.58	GO:0042988	X11-like protein binding
0.54	GO:0001540	amyloid-beta binding
0.53	GO:0019894	kinesin binding
0.40	GO:0008013	beta-catenin binding

0.53	GO:0014069	postsynaptic density
0.51	GO:0045211	postsynaptic membrane
0.49	GO:0009986	cell surface
0.48	GO:0005615	extracellular space
0.36	GO:0030054	cell junction
0.36	GO:0000139	Golgi membrane
0.36	GO:0005789	endoplasmic reticulum membrane
0.35	GO:1903561	extracellular vesicle
0.35	GO:0042995	cell projection
0.34	GO:0005634	nucleus

sp|O94986|CE152_HUMAN
Centrosomal protein of 152 kDa
Search

CEP152

0.90	Centrosomal protein of 152 kDa

0.86	GO:0098535	de novo centriole assembly involved in multi-ciliated epithelial cell differentiation
0.85	GO:0007099	centriole replication
0.42	GO:0097711	ciliary basal body-plasma membrane docking
0.41	GO:0000086	G2/M transition of mitotic cell cycle
0.40	GO:0010389	regulation of G2/M transition of mitotic cell cycle
0.35	GO:0035556	intracellular signal transduction
0.32	GO:0007018	microtubule-based movement

0.60	GO:0019901	protein kinase binding
0.32	GO:0051015	actin filament binding
0.32	GO:0003777	microtubule motor activity
0.32	GO:0008017	microtubule binding
0.31	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.86	GO:0098536	deuterosome
0.75	GO:0005815	microtubule organizing center
0.53	GO:0005654	nucleoplasm
0.45	GO:0044444	cytoplasmic part
0.32	GO:0016459	myosin complex
0.30	GO:0016020	membrane

sp|O94988|FA13A_HUMAN
Protein FAM13A
Search

0.10	Putative gtpase-activator protein (Fragment)

0.60	GO:0007165	signal transduction
0.37	GO:0051056	regulation of small GTPase mediated signal transduction
0.37	GO:0043547	positive regulation of GTPase activity

0.37	GO:0005096	GTPase activator activity
0.33	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

0.36

GO:0005829

cytosol

0.33

EC:2.3.3

GO:0046912

sp|O94989|ARHGF_HUMAN
Rho guanine nucleotide exchange factor 15
Search

ARHGEF15

0.97	Rho guanine nucleotide exchange factor 15

0.78	GO:0035023	regulation of Rho protein signal transduction
0.67	GO:2000297	negative regulation of synapse maturation
0.66	GO:0065009	regulation of molecular function
0.62	GO:0061299	retina vasculature morphogenesis in camera-type eye
0.56	GO:0051496	positive regulation of stress fiber assembly
0.37	GO:0007165	signal transduction
0.35	GO:0061002	negative regulation of dendritic spine morphogenesis
0.33	GO:0043065	positive regulation of apoptotic process
0.32	GO:0006310	DNA recombination

0.78	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.37	GO:0005096	GTPase activator activity
0.33	GO:0046875	ephrin receptor binding
0.32	GO:0070035	purine NTP-dependent helicase activity
0.32	GO:0042623	ATPase activity, coupled
0.31	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding
0.31	GO:0003676	nucleic acid binding

0.60	GO:0030425	dendrite
0.39	GO:0005737	cytoplasm
0.35	GO:0030426	growth cone
0.30	GO:0016020	membrane

sp|O94991|SLIK5_HUMAN
SLIT and NTRK-like protein 5
Search

SLITRK5

0.96	Leucine-rich repeat-containing protein 11

0.61	GO:0051965	positive regulation of synapse assembly
0.60	GO:0007625	grooming behavior
0.60	GO:0021756	striatum development
0.59	GO:0007409	axonogenesis
0.57	GO:0048813	dendrite morphogenesis
0.57	GO:0043588	skin development
0.56	GO:0030534	adult behavior
0.55	GO:0072358	cardiovascular system development
0.54	GO:0007268	chemical synaptic transmission
0.54	GO:0009410	response to xenobiotic stimulus

0.58	GO:0043235	receptor complex
0.34	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O94992|HEXI1_HUMAN
Protein HEXIM1
Search

HEXIM1

0.97	Hexamethylene bis-acetamide inducible 1

0.82	GO:0071901	negative regulation of protein serine/threonine kinase activity
0.78	GO:0000122	negative regulation of transcription by RNA polymerase II
0.77	GO:1904030	negative regulation of cyclin-dependent protein kinase activity
0.73	GO:1901798	positive regulation of signal transduction by p53 class mediator
0.71	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
0.68	GO:0045786	negative regulation of cell cycle
0.67	GO:0002218	activation of innate immune response
0.66	GO:0007507	heart development

0.85	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
0.83	GO:0017069	snRNA binding
0.47	GO:0042802	identical protein binding

0.63	GO:0005654	nucleoplasm
0.49	GO:0005737	cytoplasm

sp|O94993|SOX30_HUMAN
Transcription factor SOX-30
Search

SOX30

0.97	Transcription factor SOX-30

0.63	GO:0031960	response to corticosteroid
0.58	GO:0007283	spermatogenesis
0.38	GO:0030238	male sex determination
0.38	GO:0006357	regulation of transcription by RNA polymerase II
0.38	GO:0007548	sex differentiation
0.37	GO:0006351	transcription, DNA-templated
0.37	GO:0030154	cell differentiation
0.34	GO:0040025	vulval development
0.34	GO:0036445	neuronal stem cell division
0.34	GO:0098722	asymmetric stem cell division

0.55	GO:0003677	DNA binding
0.39	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.37	GO:0005516	calmodulin binding
0.33	GO:0008234	cysteine-type peptidase activity
0.32	GO:0004084	branched-chain-amino-acid transaminase activity

0.61	GO:0005634	nucleus
0.36	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0008234

sp|O95006|OR2F2_HUMAN
Olfactory receptor 2F2
Search

0.45	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.72	GO:0004930	G-protein coupled receptor activity
0.34	GO:0005549	odorant binding

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O95007|OR6B1_HUMAN
Olfactory receptor 6B1
Search

OR6B1

0.45	Olfactory receptor

0.75	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.70	GO:0007186	G-protein coupled receptor signaling pathway

0.75	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity
0.38	GO:0005549	odorant binding

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O95013|O4F21_HUMAN
Olfactory receptor 4F21
Search

0.46	Olfactory receptor

0.75	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.72	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O95025|SEM3D_HUMAN
Semaphorin-3D
Search

SEMA3D

0.97	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D

0.64	GO:0050919	negative chemotaxis
0.51	GO:1903045	neural crest cell migration involved in sympathetic nervous system development
0.51	GO:0007413	axonal fasciculation
0.51	GO:2001224	positive regulation of neuron migration
0.51	GO:1903375	facioacoustic ganglion development
0.50	GO:0021828	gonadotrophin-releasing hormone neuronal migration to the hypothalamus
0.50	GO:0036486	ventral trunk neural crest cell migration
0.50	GO:0097490	sympathetic neuron projection extension
0.50	GO:0097491	sympathetic neuron projection guidance
0.50	GO:0140059	dendrite arborization

0.66	GO:0038191	neuropilin binding
0.50	GO:0045499	chemorepellent activity
0.50	GO:0030215	semaphorin receptor binding

0.65	GO:0005615	extracellular space
0.42	GO:0030424	axon
0.38	GO:0030425	dendrite
0.38	GO:0044297	cell body
0.30	GO:0016020	membrane

sp|O95045|UPP2_HUMAN
Uridine phosphorylase 2
Search

UPP2

0.59	Uridine phosphorylase

0.77	GO:0044206	UMP salvage
0.74	GO:0009166	nucleotide catabolic process
0.47	GO:0046108	uridine metabolic process
0.45	GO:0046135	pyrimidine nucleoside catabolic process
0.43	GO:0042454	ribonucleoside catabolic process
0.38	GO:0042149	cellular response to glucose starvation
0.34	GO:0043413	macromolecule glycosylation
0.34	GO:0009101	glycoprotein biosynthetic process
0.33	GO:0036211	protein modification process
0.32	GO:0044267	cellular protein metabolic process

0.82	GO:0004850	uridine phosphorylase activity
0.37	GO:0042802	identical protein binding
0.33	GO:0030246	carbohydrate binding

0.53	GO:0045098	type III intermediate filament
0.48	GO:0005737	cytoplasm
0.41	GO:0005654	nucleoplasm
0.33	GO:0012505	endomembrane system
0.30	GO:0016021	integral component of membrane

0.82

EC:2.4.2.3

GO:0004850

sp|O95047|OR2A4_HUMAN
Olfactory receptor 2A4
Search

0.44	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.35	GO:0032467	positive regulation of cytokinesis
0.34	GO:0032956	regulation of actin cytoskeleton organization

0.76	GO:0004984	olfactory receptor activity
0.72	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.37	GO:0090543	Flemming body
0.37	GO:0097431	mitotic spindle pole
0.37	GO:0032154	cleavage furrow
0.37	GO:1990023	mitotic spindle midzone
0.36	GO:0055037	recycling endosome
0.30	GO:0016021	integral component of membrane

sp|O95049|ZO3_HUMAN
Tight junction protein ZO-3
Search

TJP3

0.93	Tight junction protein ZO-3

0.40	GO:2000045	regulation of G1/S transition of mitotic cell cycle
0.40	GO:0001825	blastocyst formation
0.39	GO:0003008	system process
0.39	GO:0090557	establishment of endothelial intestinal barrier
0.38	GO:0090559	regulation of membrane permeability
0.37	GO:2001205	negative regulation of osteoclast development
0.37	GO:0007586	digestion
0.37	GO:0071847	TNFSF11-mediated signaling pathway
0.34	GO:0007043	cell-cell junction assembly
0.34	GO:1901350	cell-cell signaling involved in cell-cell junction organization

0.40	GO:0071253	connexin binding
0.40	GO:0019904	protein domain specific binding
0.38	GO:0045296	cadherin binding
0.37	GO:0030674	protein binding, bridging
0.34	GO:0005516	calmodulin binding
0.33	GO:0008022	protein C-terminus binding

0.81	GO:0005923	bicellular tight junction
0.48	GO:0005634	nucleus
0.43	GO:0016324	apical plasma membrane
0.40	GO:0046581	intercellular canaliculus
0.40	GO:0016327	apicolateral plasma membrane
0.40	GO:0014704	intercalated disc
0.39	GO:0005913	cell-cell adherens junction
0.39	GO:0005829	cytosol
0.38	GO:0009986	cell surface
0.35	GO:0043234	protein complex

sp|O95050|INMT_HUMAN
Indolethylamine N-methyltransferase
Search

NNMT

0.89	Indolethylamine N-methyltransferase

0.63	GO:0032259	methylation
0.39	GO:0042418	epinephrine biosynthetic process
0.39	GO:0031100	animal organ regeneration
0.39	GO:0009308	amine metabolic process
0.39	GO:0042221	response to chemical
0.35	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway
0.34	GO:0035900	response to isolation stress
0.34	GO:0035902	response to immobilization stress
0.34	GO:0042415	norepinephrine metabolic process
0.34	GO:0030325	adrenal gland development

0.63	GO:0008168	methyltransferase activity
0.34	GO:0005515	protein binding

0.48	GO:0005829	cytosol
0.34	GO:0043196	varicosity
0.34	GO:0043204	perikaryon
0.34	GO:0043195	terminal bouton
0.33	GO:0030425	dendrite

0.63

GO:0008168

sp|O95057|DIRA1_HUMAN
GTP-binding protein Di-Ras1
Search

DIRAS1

0.91	GTP-binding protein Di-Ras1

0.61	GO:0007165	signal transduction
0.44	GO:0061551	trigeminal ganglion development
0.41	GO:0048666	neuron development
0.37	GO:0043406	positive regulation of MAP kinase activity
0.34	GO:0030001	metal ion transport
0.33	GO:0055085	transmembrane transport

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0051019	mitogen-activated protein kinase binding
0.34	GO:0046873	metal ion transmembrane transporter activity

0.44	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O95067|CCNB2_HUMAN
G2/mitotic-specific cyclin-B2
Search

CCNB2

0.97	Mitotic specific cyclin B2

0.56	GO:0043029	T cell homeostasis
0.55	GO:0048538	thymus development
0.54	GO:0001701	in utero embryonic development
0.52	GO:0040007	growth
0.46	GO:2000775	histone H3-S10 phosphorylation involved in chromosome condensation
0.46	GO:0031662	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
0.45	GO:1905448	positive regulation of mitochondrial ATP synthesis coupled electron transport
0.44	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore
0.44	GO:0048146	positive regulation of fibroblast proliferation
0.44	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint

0.55	GO:0045296	cadherin binding
0.45	GO:0005113	patched binding
0.43	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity
0.42	GO:0044389	ubiquitin-like protein ligase binding
0.42	GO:0019901	protein kinase binding
0.38	GO:0016301	kinase activity
0.34	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.34	GO:0016874	ligase activity
0.34	GO:0060089	molecular transducer activity
0.34	GO:0140096	catalytic activity, acting on a protein

0.61	GO:0005634	nucleus
0.56	GO:0005813	centrosome
0.51	GO:0005829	cytosol
0.45	GO:0097125	cyclin B1-CDK1 complex
0.42	GO:0000940	condensed chromosome outer kinetochore
0.42	GO:0000922	spindle pole
0.41	GO:0005759	mitochondrial matrix
0.30	GO:0016020	membrane

0.34

GO:0016773

sp|O95069|KCNK2_HUMAN
Potassium channel subfamily K member 2
Search

KCNK2

0.97	Potassium two pore domain channel subfamily K member 2

0.73	GO:0071805	potassium ion transmembrane transport
0.53	GO:0042391	regulation of membrane potential
0.48	GO:0007186	G-protein coupled receptor signaling pathway
0.40	GO:1900039	positive regulation of cellular response to hypoxia
0.39	GO:0060044	negative regulation of cardiac muscle cell proliferation
0.39	GO:0090102	cochlea development
0.39	GO:0048678	response to axon injury
0.39	GO:2000279	negative regulation of DNA biosynthetic process
0.38	GO:0071456	cellular response to hypoxia
0.38	GO:0003231	cardiac ventricle development

0.76	GO:0005267	potassium channel activity
0.57	GO:0022842	narrow pore channel activity
0.55	GO:0022843	voltage-gated cation channel activity
0.38	GO:0019870	potassium channel inhibitor activity
0.34	GO:0005515	protein binding

0.52	GO:0008076	voltage-gated potassium channel complex
0.40	GO:0044305	calyx of Held
0.39	GO:0097449	astrocyte projection
0.38	GO:0016324	apical plasma membrane
0.38	GO:0043025	neuronal cell body
0.38	GO:0030424	axon
0.37	GO:0009986	cell surface
0.35	GO:0005789	endoplasmic reticulum membrane
0.35	GO:0005634	nucleus

sp|O95070|YIF1A_HUMAN
Protein YIF1A
Search

YIF1A

0.97	Yip1 interacting factor homolog A

0.48

GO:0006888

ER to Golgi vesicle-mediated transport

0.59	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.49	GO:0030173	integral component of Golgi membrane
0.48	GO:0030134	COPII-coated ER to Golgi transport vesicle
0.45	GO:0005789	endoplasmic reticulum membrane

sp|O95071|UBR5_HUMAN
E3 ubiquitin-protein ligase UBR5
Search

UBR5

0.92	Ubiquitin protein ligase E3 component n-recognin 5

0.71	GO:0016567	protein ubiquitination
0.58	GO:1901314	regulation of histone H2A K63-linked ubiquitination
0.58	GO:0033183	negative regulation of histone ubiquitination
0.58	GO:1900045	negative regulation of protein K63-linked ubiquitination
0.57	GO:0050847	progesterone receptor signaling pathway
0.57	GO:0035413	positive regulation of catenin import into nucleus
0.57	GO:0033160	positive regulation of protein import into nucleus, translocation
0.56	GO:2000780	negative regulation of double-strand break repair
0.54	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.49	GO:0010628	positive regulation of gene expression

0.76	GO:0043130	ubiquitin binding
0.72	GO:0004842	ubiquitin-protein transferase activity
0.62	GO:0008270	zinc ion binding
0.58	GO:0003723	RNA binding
0.55	GO:0016874	ligase activity
0.52	GO:0061659	ubiquitin-like protein ligase activity
0.34	GO:0019904	protein domain specific binding

0.52	GO:0048471	perinuclear region of cytoplasm
0.48	GO:0005654	nucleoplasm
0.48	GO:0005829	cytosol
0.43	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

0.55	EC:6	GO:0016874
0.72	KEGG:R03876	GO:0004842

sp|O95072|REC8_HUMAN
Meiotic recombination protein REC8 homolog
Search

REC8

0.90	Meiotic recombination protein REC8 homolog

0.71	GO:0072520	seminiferous tubule development
0.71	GO:0001556	oocyte maturation
0.70	GO:0007141	male meiosis I
0.69	GO:0007130	synaptonemal complex assembly
0.66	GO:0007286	spermatid development
0.66	GO:0009566	fertilization
0.64	GO:0006302	double-strand break repair
0.62	GO:0000725	recombinational repair
0.52	GO:0007062	sister chromatid cohesion
0.41	GO:0007131	reciprocal meiotic recombination

0.51	GO:0003682	chromatin binding
0.36	GO:0005515	protein binding

0.76	GO:0030893	meiotic cohesin complex
0.74	GO:0000798	nuclear cohesin complex
0.71	GO:0000800	lateral element
0.70	GO:0001673	male germ cell nucleus
0.65	GO:0000778	condensed nuclear chromosome kinetochore
0.35	GO:0005654	nucleoplasm

sp|O95073|FSBP_HUMAN
Fibrinogen silencer-binding protein
Search

FSBP

0.97	Fibrinogen silencer-binding protein

0.53	GO:0097659	nucleic acid-templated transcription
0.52	GO:1903506	regulation of nucleic acid-templated transcription
0.52	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.52	GO:0010468	regulation of gene expression
0.50	GO:0010467	gene expression
0.49	GO:0034645	cellular macromolecule biosynthetic process

0.66

GO:0042802

identical protein binding

0.61

GO:0005634

nucleus

sp|O95076|ALX3_HUMAN
Homeobox protein aristaless-like 3
Search

ALX3

0.91	ALX homeobox protein 1

0.73	GO:0048704	embryonic skeletal system morphogenesis
0.70	GO:1904888	cranial skeletal system development
0.64	GO:0035116	embryonic hindlimb morphogenesis
0.64	GO:0035115	embryonic forelimb morphogenesis
0.59	GO:0007389	pattern specification process
0.56	GO:0042981	regulation of apoptotic process
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.48	GO:0060021	palate development

0.63	GO:0043565	sequence-specific DNA binding
0.49	GO:0003700	DNA binding transcription factor activity
0.48	GO:0071837	HMG box domain binding
0.45	GO:0001012	RNA polymerase II regulatory region DNA binding
0.44	GO:0046982	protein heterodimerization activity
0.43	GO:0003690	double-stranded DNA binding

0.60	GO:0005634	nucleus
0.44	GO:0005667	transcription factor complex
0.35	GO:0005794	Golgi apparatus
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part

sp|O95081|AGFG2_HUMAN
Arf-GAP domain and FG repeat-containing protein 2
Search

AGFG2

0.82	Arf-GAP domain and FG repeats-containing protein 2

0.76	GO:0043547	positive regulation of GTPase activity
0.45	GO:0001675	acrosome assembly
0.44	GO:0045109	intermediate filament organization
0.44	GO:0007289	spermatid nucleus differentiation
0.35	GO:0007275	multicellular organism development
0.33	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.33	GO:0051028	mRNA transport
0.33	GO:0006405	RNA export from nucleus
0.33	GO:0061024	membrane organization
0.32	GO:0010467	gene expression

0.76	GO:0005096	GTPase activator activity
0.52	GO:0046872	metal ion binding
0.33	GO:0003677	DNA binding
0.32	GO:0005515	protein binding
0.32	GO:0003723	RNA binding

0.43	GO:0043025	neuronal cell body
0.41	GO:0031410	cytoplasmic vesicle
0.39	GO:0042995	cell projection
0.37	GO:0043231	intracellular membrane-bounded organelle
0.33	GO:0005829	cytosol
0.33	GO:0012505	endomembrane system
0.32	GO:0031967	organelle envelope
0.32	GO:0043234	protein complex
0.30	GO:0016020	membrane

sp|O95084|PRS23_HUMAN
Serine protease 23
Search

PRSS23

0.46	Serine protease

0.60	GO:0006508	proteolysis
0.38	GO:0003160	endocardium morphogenesis
0.38	GO:0003171	atrioventricular valve development
0.37	GO:0008593	regulation of Notch signaling pathway
0.35	GO:0043687	post-translational protein modification
0.34	GO:1902475	L-alpha-amino acid transmembrane transport

0.67	GO:0004252	serine-type endopeptidase activity
0.32	GO:0022857	transmembrane transporter activity

0.52	GO:0005615	extracellular space
0.46	GO:0005634	nucleus
0.37	GO:1903561	extracellular vesicle
0.35	GO:0005788	endoplasmic reticulum lumen
0.30	GO:0016020	membrane

0.67

GO:0004252

sp|O95096|NKX22_HUMAN
Homeobox protein Nkx-2.2
Search

NKX2-2

0.93	Homeobox protein Nkx-2.2

0.61	GO:0003327	type B pancreatic cell fate commitment
0.61	GO:0060580	ventral spinal cord interneuron fate determination
0.61	GO:0021530	spinal cord oligodendrocyte cell fate specification
0.60	GO:0003326	pancreatic A cell fate commitment
0.60	GO:0003329	pancreatic PP cell fate commitment
0.59	GO:0048714	positive regulation of oligodendrocyte differentiation
0.58	GO:0003323	type B pancreatic cell development
0.58	GO:0021782	glial cell development
0.57	GO:0048708	astrocyte differentiation
0.57	GO:0021522	spinal cord motor neuron differentiation

0.64	GO:0043565	sequence-specific DNA binding
0.53	GO:0003713	transcription coactivator activity
0.52	GO:0003682	chromatin binding
0.52	GO:0044212	transcription regulatory region DNA binding
0.51	GO:0008134	transcription factor binding
0.50	GO:0003690	double-stranded DNA binding
0.46	GO:0003700	DNA binding transcription factor activity
0.33	GO:0004000	adenosine deaminase activity

0.61	GO:0005634	nucleus
0.35	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:3.5.4.4

GO:0004000

sp|O95104|SFR15_HUMAN
Splicing factor, arginine/serine-rich 15
Search

SCAF4

0.96	Splicing factor, arginine/serine-rich 15

0.34	GO:0006397	mRNA processing
0.32	GO:0018298	protein-chromophore linkage

0.59	GO:0003723	RNA binding
0.35	GO:0008022	protein C-terminus binding

0.52	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O95125|ZN202_HUMAN
Zinc finger protein 202
Search

0.71	Zinc finger protein 202

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.49	GO:0006351	transcription, DNA-templated
0.48	GO:1902679	negative regulation of RNA biosynthetic process
0.33	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.33	GO:0006629	lipid metabolic process
0.32	GO:0007186	G-protein coupled receptor signaling pathway

0.60	GO:0003700	DNA binding transcription factor activity
0.51	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.50	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding
0.33	GO:0004984	olfactory receptor activity
0.32	GO:0004930	G-protein coupled receptor activity

0.58	GO:0005634	nucleus
0.39	GO:0005829	cytosol
0.39	GO:0031974	membrane-enclosed lumen
0.37	GO:0044446	intracellular organelle part
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O95136|S1PR2_HUMAN
Sphingosine 1-phosphate receptor 2
Search

S1PR2

0.96	Endothelial differentiation, sphingolipid G-protein-coupled receptor, 1

0.85	GO:0003376	sphingosine-1-phosphate signaling pathway
0.58	GO:1901552	positive regulation of endothelial cell development
0.57	GO:1903140	regulation of establishment of endothelial barrier
0.57	GO:0090394	negative regulation of excitatory postsynaptic potential
0.56	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
0.56	GO:0046847	filopodium assembly
0.52	GO:0031532	actin cytoskeleton reorganization
0.45	GO:0035676	anterior lateral line neuromast hair cell development
0.44	GO:0035677	posterior lateral line neuromast hair cell development
0.44	GO:0003319	cardioblast migration to the midline involved in heart rudiment formation

0.86	GO:0038036	sphingosine-1-phosphate receptor activity
0.55	GO:0005178	integrin binding
0.54	GO:0001664	G-protein coupled receptor binding
0.35	GO:0003886	DNA (cytosine-5-)-methyltransferase activity
0.34	GO:0003682	chromatin binding
0.34	GO:0008289	lipid binding
0.33	GO:0070915	lysophosphatidic acid receptor activity
0.33	GO:0008270	zinc ion binding
0.32	GO:0003677	DNA binding
0.32	GO:0016491	oxidoreductase activity

0.43	GO:0005886	plasma membrane
0.37	GO:0009986	cell surface
0.37	GO:0098552	side of membrane
0.36	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.35

EC:2.1.1.37

GO:0003886

sp|O95139|NDUB6_HUMAN
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
Search

NDUFB6

0.97	NADH dehydrogenase 1 beta subcomplex subunit 6

0.65	GO:0032981	mitochondrial respiratory chain complex I assembly
0.54	GO:0042775	mitochondrial ATP synthesis coupled electron transport

0.38	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.34	GO:0016874	ligase activity

0.62	GO:0005747	mitochondrial respiratory chain complex I
0.53	GO:0005654	nucleoplasm
0.30	GO:0016021	integral component of membrane

0.38

GO:0008137

sp|O95140|MFN2_HUMAN
Mitofusin-2
Search

MFN2

0.97	Putative mitofusin 1 gtpase involved in mitochondrila bioproteinsis

0.85	GO:0008053	mitochondrial fusion
0.84	GO:0048662	negative regulation of smooth muscle cell proliferation
0.58	GO:0051646	mitochondrion localization
0.57	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process
0.57	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
0.55	GO:1904707	positive regulation of vascular smooth muscle cell proliferation
0.55	GO:0034497	protein localization to phagophore assembly site
0.53	GO:0046580	negative regulation of Ras protein signal transduction
0.53	GO:0048593	camera-type eye morphogenesis
0.53	GO:0001825	blastocyst formation

0.68	GO:0003924	GTPase activity
0.65	GO:0005525	GTP binding
0.51	GO:0031625	ubiquitin protein ligase binding
0.35	GO:0043394	proteoglycan binding
0.34	GO:0008475	procollagen-lysine 5-dioxygenase activity
0.34	GO:0017016	Ras GTPase binding
0.34	GO:0042803	protein homodimerization activity
0.34	GO:0031418	L-ascorbic acid binding
0.32	GO:0005506	iron ion binding
0.32	GO:0003676	nucleic acid binding

0.77	GO:0005741	mitochondrial outer membrane
0.47	GO:0015630	microtubule cytoskeleton
0.46	GO:0098573	intrinsic component of mitochondrial membrane
0.44	GO:1904115	axon cytoplasm
0.37	GO:0005829	cytosol
0.33	GO:0005783	endoplasmic reticulum
0.30	GO:0016021	integral component of membrane

0.34

EC:1.14.11.4

GO:0008475

sp|O95147|DUS14_HUMAN
Dual specificity protein phosphatase 14
Search

DUSP14

0.94	Dual-specificity protein phosphatase 6

0.80	GO:0000188	inactivation of MAPK activity
0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.33	GO:0006626	protein targeting to mitochondrion
0.33	GO:0006612	protein targeting to membrane
0.32	GO:0007018	microtubule-based movement

0.81	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
0.74	GO:0004725	protein tyrosine phosphatase activity
0.34	GO:0003723	RNA binding
0.33	GO:0005515	protein binding
0.32	GO:0003677	DNA binding
0.32	GO:0003777	microtubule motor activity
0.31	GO:0030554	adenyl nucleotide binding
0.31	GO:0032555	purine ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.35	GO:0005634	nucleus
0.34	GO:0005863	striated muscle myosin thick filament
0.33	GO:0031314	extrinsic component of mitochondrial inner membrane
0.33	GO:0005758	mitochondrial intermembrane space
0.33	GO:0005759	mitochondrial matrix
0.30	GO:0031224	intrinsic component of membrane

0.81

GO:0017017

sp|O95149|SPN1_HUMAN
Snurportin-1
Search

SNUPN

0.92	Snurportin-1 isoform B

0.81	GO:0061015	snRNA import into nucleus
0.75	GO:0006606	protein import into nucleus
0.38	GO:0006397	mRNA processing
0.38	GO:0036260	RNA capping
0.36	GO:0045903	positive regulation of translational fidelity
0.35	GO:0022613	ribonucleoprotein complex biogenesis
0.35	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
0.34	GO:0071826	ribonucleoprotein complex subunit organization
0.34	GO:0035335	peptidyl-tyrosine dephosphorylation
0.34	GO:0034622	cellular macromolecular complex assembly

0.78	GO:0061608	nuclear import signal receptor activity
0.55	GO:0008565	protein transporter activity
0.49	GO:0003723	RNA binding
0.39	GO:0004484	mRNA guanylyltransferase activity
0.34	GO:0004725	protein tyrosine phosphatase activity
0.33	GO:0005515	protein binding
0.33	GO:0003735	structural constituent of ribosome

0.56	GO:0005634	nucleus
0.45	GO:0005737	cytoplasm
0.37	GO:0070062	extracellular exosome
0.35	GO:0012505	endomembrane system
0.35	GO:0005846	nuclear cap binding complex
0.35	GO:0030686	90S preribosome
0.35	GO:0043234	protein complex
0.35	GO:0032040	small-subunit processome
0.35	GO:0044446	intracellular organelle part
0.34	GO:0031975	envelope

0.39

EC:2.7.7.50

GO:0004484

sp|O95150|TNF15_HUMAN
Tumor necrosis factor ligand superfamily member 15
Search

TNFSF15

0.97	Vascular endothelial cell growth inhibitor

0.78	GO:0006915	apoptotic process
0.75	GO:0010469	regulation of receptor activity
0.74	GO:0006955	immune response
0.68	GO:0042107	cytokine metabolic process
0.67	GO:0007250	activation of NF-kappaB-inducing kinase activity
0.65	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
0.37	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.36	GO:0050715	positive regulation of cytokine secretion

0.84	GO:0005164	tumor necrosis factor receptor binding
0.80	GO:0005125	cytokine activity
0.37	GO:0005123	death receptor binding

0.73	GO:0005615	extracellular space
0.46	GO:0005886	plasma membrane
0.40	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

sp|O95153|RIMB1_HUMAN
Peripheral-type benzodiazepine receptor-associated protein 1
Search

TSPOAP1

0.95	TSPO associated protein 1

0.86	GO:0030156	benzodiazepine receptor binding
0.35	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity

0.51

GO:0005739

mitochondrion

0.35

GO:0004114

sp|O95154|ARK73_HUMAN
Aflatoxin B1 aldehyde reductase member 3
Search

AKR7A2

0.85	Aflatoxin aldehyde reductase

0.54	GO:0044598	doxorubicin metabolic process
0.54	GO:0044597	daunorubicin metabolic process
0.49	GO:0055114	oxidation-reduction process
0.41	GO:0006805	xenobiotic metabolic process
0.39	GO:0046223	aflatoxin catabolic process
0.38	GO:0006081	cellular aldehyde metabolic process
0.36	GO:0006091	generation of precursor metabolites and energy
0.34	GO:0005975	carbohydrate metabolic process

0.56	GO:0019119	phenanthrene-9,10-epoxide hydrolase activity
0.50	GO:0016491	oxidoreductase activity
0.40	GO:0042802	identical protein binding

0.47	GO:0005829	cytosol
0.46	GO:0005739	mitochondrion
0.45	GO:0070062	extracellular exosome
0.39	GO:0005794	Golgi apparatus
0.35	GO:0031984	organelle subcompartment

0.56

EC:3.3.2

GO:0019119

sp|O95155|UBE4B_HUMAN
Ubiquitin conjugation factor E4 B
Search

UBE4B

0.93	Ubiquitination factor E4/UFD2

0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.73	GO:0016567	protein ubiquitination
0.57	GO:0008626	granzyme-mediated apoptotic signaling pathway
0.56	GO:0003222	ventricular trabecula myocardium morphogenesis
0.55	GO:0034976	response to endoplasmic reticulum stress
0.53	GO:0010498	proteasomal protein catabolic process
0.52	GO:0009411	response to UV
0.51	GO:0031175	neuron projection development
0.46	GO:0010243	response to organonitrogen compound

0.85	GO:0034450	ubiquitin-ubiquitin ligase activity
0.48	GO:0019899	enzyme binding
0.41	GO:0032559	adenyl ribonucleotide binding
0.41	GO:0008144	drug binding
0.41	GO:0035639	purine ribonucleoside triphosphate binding

0.76	GO:0000151	ubiquitin ligase complex
0.46	GO:0005634	nucleus
0.40	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O95156|NXPH2_HUMAN
Neurexophilin-2
Search

NXPH2

0.92	Neurexophilin

0.40

GO:0007218

neuropeptide signaling pathway

0.72

GO:0005102

receptor binding

0.46	GO:0005576	extracellular region
0.30	GO:0044425	membrane part

sp|O95157|NXPH3_HUMAN
Neurexophilin-3
Search

NXPH3

0.90	Neurexophilin

0.39

GO:0007218

neuropeptide signaling pathway

0.72

GO:0005102

receptor binding

0.42	GO:0005576	extracellular region
0.30	GO:0044425	membrane part

sp|O95158|NXPH4_HUMAN
Neurexophilin-4
Search

NXPH4

0.79	Neurexophilin

0.44	GO:0007218	neuropeptide signaling pathway
0.40	GO:0019264	glycine biosynthetic process from serine
0.39	GO:0035999	tetrahydrofolate interconversion
0.37	GO:0032259	methylation

0.71	GO:0005102	receptor binding
0.40	GO:0004372	glycine hydroxymethyltransferase activity
0.37	GO:0030170	pyridoxal phosphate binding
0.37	GO:0008168	methyltransferase activity

0.45	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.40

EC:2.1.2.1

GO:0004372

sp|O95159|ZFPL1_HUMAN
Zinc finger protein-like 1
Search

ZFPL1

0.82	Zinc finger protein like 1

0.38	GO:0016192	vesicle-mediated transport
0.34	GO:0032367	intracellular cholesterol transport
0.34	GO:0033227	dsRNA transport
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.33	GO:0010468	regulation of gene expression
0.32	GO:0055114	oxidation-reduction process

0.37	GO:0046872	metal ion binding
0.35	GO:0016874	ligase activity
0.34	GO:0005515	protein binding
0.33	GO:0003677	DNA binding
0.33	GO:0008080	N-acetyltransferase activity
0.32	GO:0016491	oxidoreductase activity

0.54	GO:0005794	Golgi apparatus
0.33	GO:0005634	nucleus
0.30	GO:0044425	membrane part

0.35

GO:0016874

sp|O95163|ELP1_HUMAN
Elongator complex protein 1
Search

ELP1

0.73	Elongator complex protein 1

0.74	GO:0002098	tRNA wobble uridine modification
0.54	GO:0006351	transcription, DNA-templated
0.54	GO:2001141	regulation of RNA biosynthetic process
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0030335	positive regulation of cell migration
0.53	GO:0010468	regulation of gene expression
0.52	GO:0045859	regulation of protein kinase activity
0.43	GO:0048484	enteric nervous system development
0.39	GO:0016310	phosphorylation
0.35	GO:0006955	immune response

0.61	GO:0008607	phosphorylase kinase regulator activity
0.56	GO:0000993	RNA polymerase II core binding
0.39	GO:0016301	kinase activity
0.34	GO:0004871	signal transducer activity
0.33	GO:0099600	transmembrane receptor activity

0.78	GO:0033588	Elongator holoenzyme complex
0.58	GO:0005634	nucleus
0.52	GO:0031248	protein acetyltransferase complex
0.49	GO:0005829	cytosol
0.48	GO:0031974	membrane-enclosed lumen
0.44	GO:0043232	intracellular non-membrane-bounded organelle
0.43	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.61

GO:0008607

sp|O95164|UBL3_HUMAN
Ubiquitin-like protein 3
Search

UBL3

0.77	Ubiquitin-like protein 3

0.66	GO:0070062	extracellular exosome
0.56	GO:0005886	plasma membrane
0.43	GO:0005622	intracellular

sp|O95166|GBRAP_HUMAN
Gamma-aminobutyric acid receptor-associated protein
Search

GABARAP

0.97	GABA(A) receptor-associated protein b

0.77	GO:0006914	autophagy
0.51	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
0.46	GO:0000226	microtubule cytoskeleton organization
0.46	GO:0006995	cellular response to nitrogen starvation
0.45	GO:0061726	mitochondrion disassembly
0.44	GO:0007033	vacuole organization
0.41	GO:0070925	organelle assembly
0.40	GO:0060322	head development
0.40	GO:0007417	central nervous system development
0.39	GO:0048513	animal organ development

0.51	GO:0050811	GABA receptor binding
0.49	GO:0048487	beta-tubulin binding
0.47	GO:0031625	ubiquitin protein ligase binding
0.46	GO:0008017	microtubule binding
0.34	GO:0016791	phosphatase activity
0.34	GO:0019901	protein kinase binding
0.32	GO:0046872	metal ion binding

0.53	GO:0000421	autophagosome membrane
0.51	GO:0005790	smooth endoplasmic reticulum
0.51	GO:0097225	sperm midpiece
0.48	GO:0005930	axoneme
0.48	GO:0005764	lysosome
0.46	GO:0005875	microtubule associated complex
0.45	GO:0015629	actin cytoskeleton
0.45	GO:0005794	Golgi apparatus
0.41	GO:0005829	cytosol
0.39	GO:0005886	plasma membrane

0.34

EC:3.1.3 EC:3.1.3.41

GO:0016791

sp|O95167|NDUA3_HUMAN
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Search

NDUFA3

0.63	Mitochondrial NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

0.53	GO:0032981	mitochondrial respiratory chain complex I assembly
0.36	GO:0055114	oxidation-reduction process
0.35	GO:0034765	regulation of ion transmembrane transport
0.35	GO:0070588	calcium ion transmembrane transport
0.34	GO:0006338	chromatin remodeling
0.34	GO:0006119	oxidative phosphorylation
0.33	GO:0006281	DNA repair
0.33	GO:0006351	transcription, DNA-templated

0.35	GO:0005262	calcium channel activity
0.35	GO:0022832	voltage-gated channel activity
0.34	GO:0022839	ion gated channel activity
0.34	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.34	GO:0008381	mechanosensitive ion channel activity
0.33	GO:0004386	helicase activity
0.33	GO:0016887	ATPase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0003677	DNA binding
0.32	GO:0097367	carbohydrate derivative binding

0.82	GO:0005747	mitochondrial respiratory chain complex I
0.34	GO:0031011	Ino80 complex
0.30	GO:0016021	integral component of membrane

0.34

GO:0008137

sp|O95168|NDUB4_HUMAN
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Search

NDUFB4

0.90	NADH:ubiquinone oxidoreductase subunit B4

0.78	GO:0032981	mitochondrial respiratory chain complex I assembly
0.66	GO:0006979	response to oxidative stress
0.53	GO:0055114	oxidation-reduction process

0.69

GO:0008137

NADH dehydrogenase (ubiquinone) activity

0.75	GO:0005747	mitochondrial respiratory chain complex I
0.72	GO:0031965	nuclear membrane
0.42	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0008137

sp|O95169|NDUB8_HUMAN
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
Search

NDUFB8

0.92	NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial

0.70	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
0.44	GO:0032981	mitochondrial respiratory chain complex I assembly
0.35	GO:0006626	protein targeting to mitochondrion

0.69

GO:0008137

NADH dehydrogenase (ubiquinone) activity

0.76	GO:0005747	mitochondrial respiratory chain complex I
0.37	GO:0005783	endoplasmic reticulum
0.34	GO:0005759	mitochondrial matrix
0.30	GO:0016021	integral component of membrane

0.69

GO:0008137

sp|O95170|CDRT1_HUMAN
CMT1A duplicated region transcript 1 protein
Search

0.83	F-box and WD repeat domain containing 10

0.71	GO:0016567	protein ubiquitination
0.58	GO:0043687	post-translational protein modification
0.36	GO:0055114	oxidation-reduction process

0.72	GO:0004842	ubiquitin-protein transferase activity
0.40	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.39	GO:0020037	heme binding
0.39	GO:0005506	iron ion binding
0.37	GO:0043531	ADP binding

0.51	GO:0005829	cytosol
0.30	GO:0044425	membrane part

0.40	EC:1.14	GO:0016705
0.72	KEGG:R03876	GO:0004842

sp|O95171|SCEL_HUMAN
Sciellin
Search

SCEL

0.93

Sciellin

0.68	GO:0030216	keratinocyte differentiation
0.68	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.67	GO:0009612	response to mechanical stimulus
0.62	GO:0009792	embryo development ending in birth or egg hatching

0.54	GO:0046872	metal ion binding
0.30	GO:0005515	protein binding

0.64	GO:0048471	perinuclear region of cytoplasm
0.44	GO:0070062	extracellular exosome
0.30	GO:0001533	cornified envelope

sp|O95177|GAAS1_HUMAN
Uncharacterized protein GAS8-AS1
Search

sp|O95178|NDUB2_HUMAN
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
Search

NDUFB2

0.41	Mitochondrial NADH dehydrogenase 1 beta subcomplex subunit 2

0.56	GO:0032981	mitochondrial respiratory chain complex I assembly
0.36	GO:0055114	oxidation-reduction process
0.34	GO:0006119	oxidative phosphorylation
0.33	GO:0016579	protein deubiquitination
0.33	GO:0006511	ubiquitin-dependent protein catabolic process

0.34	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.33	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.33	GO:0005509	calcium ion binding

0.81	GO:0005747	mitochondrial respiratory chain complex I
0.30	GO:0016021	integral component of membrane

0.34

GO:0008137

sp|O95180|CAC1H_HUMAN
Voltage-dependent T-type calcium channel subunit alpha-1H
Search

CACNA1H

0.78	Voltage-dependent T-type calcium channel subunit alpha

0.76	GO:0070588	calcium ion transmembrane transport
0.64	GO:0070509	calcium ion import
0.62	GO:0019228	neuronal action potential
0.57	GO:0034651	cortisol biosynthetic process
0.56	GO:0032341	aldosterone metabolic process
0.56	GO:0006705	mineralocorticoid biosynthetic process
0.55	GO:0030317	flagellated sperm motility
0.55	GO:0035865	cellular response to potassium ion
0.55	GO:2000344	positive regulation of acrosome reaction
0.55	GO:0006700	C21-steroid hormone biosynthetic process

0.80	GO:0005245	voltage-gated calcium channel activity
0.54	GO:0097110	scaffold protein binding
0.49	GO:0005248	voltage-gated sodium channel activity
0.35	GO:0046872	metal ion binding

0.79	GO:0005891	voltage-gated calcium channel complex
0.45	GO:0005887	integral component of plasma membrane
0.38	GO:0042383	sarcolemma
0.38	GO:0005901	caveola
0.36	GO:0043204	perikaryon
0.36	GO:0030425	dendrite
0.34	GO:0005634	nucleus
0.33	GO:0005737	cytoplasm

sp|O95182|NDUA7_HUMAN
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Search

NDUFA7

0.41	Mitochondrial NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

0.69	GO:0042773	ATP synthesis coupled electron transport
0.39	GO:0032543	mitochondrial translation
0.36	GO:0032981	mitochondrial respiratory chain complex I assembly

0.69	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.36	GO:0003735	structural constituent of ribosome

0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane
0.50	GO:0045271	respiratory chain complex I
0.47	GO:0098798	mitochondrial protein complex
0.46	GO:1990204	oxidoreductase complex
0.39	GO:0005761	mitochondrial ribosome
0.30	GO:0016021	integral component of membrane

0.69

GO:0008137

sp|O95183|VAMP5_HUMAN
Vesicle-associated membrane protein 5
Search

VAMP5

0.97	Vesicle-associated membrane protein 5

0.71	GO:0043001	Golgi to plasma membrane protein transport
0.69	GO:0007519	skeletal muscle tissue development
0.55	GO:0006906	vesicle fusion
0.52	GO:0006887	exocytosis
0.43	GO:0030154	cell differentiation

0.54	GO:0000149	SNARE binding
0.54	GO:0005484	SNAP receptor activity

0.71	GO:0014704	intercalated disc
0.67	GO:0005770	late endosome
0.66	GO:0048471	perinuclear region of cytoplasm
0.65	GO:0009986	cell surface
0.64	GO:0031301	integral component of organelle membrane
0.64	GO:0030659	cytoplasmic vesicle membrane
0.57	GO:0005887	integral component of plasma membrane
0.55	GO:0031201	SNARE complex
0.42	GO:0005794	Golgi apparatus
0.41	GO:0070062	extracellular exosome

sp|O95185|UNC5C_HUMAN
Netrin receptor UNC5C
Search

UNC5C

0.92	Unc-5 netrin receptor C

0.85	GO:0038007	netrin-activated signaling pathway
0.57	GO:0033564	anterior/posterior axon guidance
0.52	GO:0007420	brain development
0.52	GO:0030334	regulation of cell migration
0.52	GO:0043065	positive regulation of apoptotic process
0.38	GO:0006915	apoptotic process

0.85

GO:0005042

netrin receptor activity

0.42	GO:0005886	plasma membrane
0.39	GO:0043005	neuron projection
0.38	GO:0045202	synapse
0.38	GO:0030054	cell junction
0.30	GO:0016021	integral component of membrane

sp|O95190|OAZ2_HUMAN
Ornithine decarboxylase antizyme 2
Search

OAZ2

0.85	Ornithine decarboxylase antizyme

0.75	GO:0006595	polyamine metabolic process
0.72	GO:0043086	negative regulation of catalytic activity
0.67	GO:1902268	negative regulation of polyamine transmembrane transport
0.62	GO:0045732	positive regulation of protein catabolic process
0.62	GO:0090316	positive regulation of intracellular protein transport
0.40	GO:0042401	cellular biogenic amine biosynthetic process
0.36	GO:0006521	regulation of cellular amino acid metabolic process
0.33	GO:0006368	transcription elongation from RNA polymerase II promoter
0.33	GO:0007283	spermatogenesis
0.32	GO:1903506	regulation of nucleic acid-templated transcription

0.85	GO:0008073	ornithine decarboxylase inhibitor activity
0.37	GO:0005515	protein binding
0.34	GO:0003723	RNA binding
0.32	GO:0008270	zinc ion binding

0.68	GO:0005829	cytosol
0.43	GO:0005634	nucleus
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0043234	protein complex
0.32	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|O95196|CSPG5_HUMAN
Chondroitin sulfate proteoglycan 5
Search

CSPG5

0.96	Chondroitin sulfate proteoglycan 5

0.59	GO:0050804	modulation of chemical synaptic transmission
0.42	GO:0040008	regulation of growth
0.42	GO:0007399	nervous system development
0.41	GO:0030154	cell differentiation
0.40	GO:0030207	chondroitin sulfate catabolic process
0.40	GO:0030208	dermatan sulfate biosynthetic process
0.39	GO:0030206	chondroitin sulfate biosynthetic process
0.38	GO:0048678	response to axon injury
0.38	GO:0031099	regeneration
0.37	GO:0010469	regulation of receptor activity

0.37

GO:0008083

growth factor activity

0.56	GO:0030660	Golgi-associated vesicle membrane
0.53	GO:0005794	Golgi apparatus
0.41	GO:0009986	cell surface
0.40	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0043202	lysosomal lumen
0.37	GO:0005886	plasma membrane
0.36	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

sp|O95197|RTN3_HUMAN
Reticulon-3
Search

RTN3

0.65

Reticulon

0.61	GO:0071787	endoplasmic reticulum tubular network formation
0.40	GO:0006915	apoptotic process
0.39	GO:0016192	vesicle-mediated transport
0.35	GO:0016032	viral process

0.36

GO:0005515

protein binding

0.71	GO:0005789	endoplasmic reticulum membrane
0.40	GO:0000139	Golgi membrane
0.39	GO:0070062	extracellular exosome
0.34	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O95198|KLHL2_HUMAN
Kelch-like protein 2
Search

KLHL2

0.96	Kelch like family member 2

0.72	GO:0016567	protein ubiquitination
0.64	GO:0070294	renal sodium ion absorption
0.63	GO:0072156	distal tubule morphogenesis
0.62	GO:0006511	ubiquitin-dependent protein catabolic process
0.53	GO:0050801	ion homeostasis

0.66	GO:0003779	actin binding
0.64	GO:0042802	identical protein binding
0.57	GO:0004842	ubiquitin-protein transferase activity

0.83	GO:0031463	Cul3-RING ubiquitin ligase complex
0.66	GO:0015629	actin cytoskeleton
0.51	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.57

GO:0004842

sp|O95199|RCBT2_HUMAN
RCC1 and BTB domain-containing protein 2
Search

RCBTB2

0.94	RCC1 and BTB domain-containing protein 2

0.37	GO:0016569	covalent chromatin modification
0.37	GO:0065009	regulation of molecular function
0.36	GO:0007049	cell cycle
0.35	GO:0006351	transcription, DNA-templated
0.34	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression

0.41

GO:0005087

Ran guanyl-nucleotide exchange factor activity

0.76	GO:0001669	acrosomal vesicle
0.35	GO:0005634	nucleus

sp|O95201|ZN205_HUMAN
Zinc finger protein 205
Search

ZNF205

0.91	Repressor of heat-inducible transcription

0.63	GO:0010729	positive regulation of hydrogen peroxide biosynthetic process
0.61	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
0.58	GO:0000122	negative regulation of transcription by RNA polymerase II
0.37	GO:0006351	transcription, DNA-templated
0.34	GO:0072707	cellular response to sodium dodecyl sulfate
0.34	GO:0006508	proteolysis
0.34	GO:0045654	positive regulation of megakaryocyte differentiation
0.34	GO:0045648	positive regulation of erythrocyte differentiation
0.33	GO:1901989	positive regulation of cell cycle phase transition
0.33	GO:0008284	positive regulation of cell proliferation

0.56	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.54	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.49	GO:0046872	metal ion binding
0.35	GO:0005515	protein binding
0.35	GO:0004222	metalloendopeptidase activity

0.46	GO:0005739	mitochondrion
0.38	GO:0005634	nucleus
0.35	GO:0031012	extracellular matrix
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0005829	cytosol
0.33	GO:0044446	intracellular organelle part
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane

0.35

GO:0004222

sp|O95202|LETM1_HUMAN
LETM1 and EF-hand domain-containing protein 1, mitochondrial
Search

LETM1

0.92	Leucine zipper and EF-hand containing transmembrane protein 1

0.70	GO:0099093	mitochondrial calcium release
0.66	GO:0006851	mitochondrial calcium ion transmembrane transport
0.66	GO:0051560	mitochondrial calcium ion homeostasis
0.64	GO:0042407	cristae formation
0.64	GO:0034214	protein hexamerization
0.57	GO:0051260	protein homooligomerization

0.74	GO:0043022	ribosome binding
0.67	GO:0005509	calcium ion binding
0.63	GO:0015369	calcium:proton antiporter activity

0.60	GO:0005739	mitochondrion
0.51	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

sp|O95206|PCDH8_HUMAN
Protocadherin-8
Search

PCDH8

0.88	Protocadherin-8

0.77	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.61	GO:0001756	somitogenesis
0.59	GO:0016331	morphogenesis of embryonic epithelium
0.50	GO:0007267	cell-cell signaling
0.50	GO:0007399	nervous system development
0.39	GO:0007616	long-term memory

0.69

GO:0005509

calcium ion binding

0.55	GO:0005886	plasma membrane
0.44	GO:0030425	dendrite
0.43	GO:0098793	presynapse
0.43	GO:0098794	postsynapse
0.42	GO:0030054	cell junction
0.30	GO:0031224	intrinsic component of membrane

sp|O95208|EPN2_HUMAN
Epsin-2
Search

EPN2

0.81	EPS-15-interacting protein 2

0.71	GO:0006897	endocytosis
0.60	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
0.59	GO:1903671	negative regulation of sprouting angiogenesis
0.58	GO:0045747	positive regulation of Notch signaling pathway
0.35	GO:0001701	in utero embryonic development
0.35	GO:0007219	Notch signaling pathway
0.35	GO:0061024	membrane organization
0.35	GO:0030100	regulation of endocytosis
0.35	GO:0048568	embryonic organ development

0.56	GO:0045296	cadherin binding
0.37	GO:0008289	lipid binding

0.85	GO:0030128	clathrin coat of endocytic vesicle
0.43	GO:0043231	intracellular membrane-bounded organelle
0.35	GO:0005829	cytosol

sp|O95210|STBD1_HUMAN
Starch-binding domain-containing protein 1
Search

STBD1

0.97	Starch-binding domain-containing protein 1

0.69	GO:0061723	glycophagy
0.54	GO:0046907	intracellular transport
0.40	GO:0043312	neutrophil degranulation

0.85	GO:2001069	glycogen binding
0.82	GO:2001070	starch binding
0.56	GO:0019899	enzyme binding

0.66	GO:0030315	T-tubule
0.61	GO:0048471	perinuclear region of cytoplasm
0.55	GO:0005783	endoplasmic reticulum
0.54	GO:0005829	cytosol
0.53	GO:0005887	integral component of plasma membrane
0.42	GO:0034045	phagophore assembly site membrane
0.41	GO:0101003	ficolin-1-rich granule membrane
0.41	GO:0070821	tertiary granule membrane
0.39	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.38	GO:0031984	organelle subcompartment

sp|O95214|LERL1_HUMAN
Leptin receptor overlapping transcript-like 1
Search

LEPROTL1

0.97	Leptin receptor overlapping transcript like 1

0.49	GO:2000009	negative regulation of protein localization to cell surface
0.46	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway
0.39	GO:0060400	negative regulation of growth hormone receptor signaling pathway
0.38	GO:0046426	negative regulation of JAK-STAT cascade
0.34	GO:1903955	positive regulation of protein targeting to mitochondrion

0.37

GO:0005515

protein binding

0.44	GO:0005768	endosome
0.33	GO:0044433	cytoplasmic vesicle part
0.33	GO:0000139	Golgi membrane
0.33	GO:0098805	whole membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O95218|ZRAB2_HUMAN
Zinc finger Ran-binding domain-containing protein 2
Search

ZRANB2

0.92	Zinc finger Ran-binding domain-containing protein 2

0.42	GO:0042742	defense response to bacterium
0.39	GO:0008380	RNA splicing
0.38	GO:0006397	mRNA processing
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression

0.55	GO:0003723	RNA binding
0.53	GO:0046872	metal ion binding
0.46	GO:0030882	lipid antigen binding
0.43	GO:0001530	lipopolysaccharide binding
0.35	GO:0004960	thromboxane receptor activity
0.34	GO:0004957	prostaglandin E receptor activity
0.33	GO:0005515	protein binding
0.33	GO:0003700	DNA binding transcription factor activity
0.32	GO:0016746	transferase activity, transferring acyl groups

0.57	GO:0005634	nucleus
0.47	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.32

EC:2.3

GO:0016746

sp|O95219|SNX4_HUMAN
Sorting nexin-4
Search

SNX4

0.91	Sorting nexin-4

0.65	GO:0015031	protein transport
0.58	GO:1903595	positive regulation of histamine secretion by mast cell
0.54	GO:0032456	endocytic recycling
0.45	GO:0016050	vesicle organization
0.43	GO:0006897	endocytosis
0.35	GO:0006869	lipid transport
0.34	GO:0007155	cell adhesion
0.33	GO:0006508	proteolysis
0.33	GO:0006518	peptide metabolic process
0.33	GO:0043604	amide biosynthetic process

0.76	GO:0035091	phosphatidylinositol binding
0.58	GO:1990460	leptin receptor binding
0.57	GO:1990459	transferrin receptor binding
0.55	GO:0005158	insulin receptor binding
0.55	GO:0005154	epidermal growth factor receptor binding
0.33	GO:0004222	metalloendopeptidase activity
0.33	GO:0003735	structural constituent of ribosome

0.54	GO:0031901	early endosome membrane
0.53	GO:0031201	SNARE complex
0.53	GO:0005868	cytoplasmic dynein complex
0.44	GO:0019898	extrinsic component of membrane
0.41	GO:0005886	plasma membrane
0.33	GO:0005840	ribosome

0.33

GO:0004222

sp|O95221|OR5F1_HUMAN
Olfactory receptor 5F1
Search

OR5

0.40	Olfactory receptor

0.75	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.70	GO:0007186	G-protein coupled receptor signaling pathway

0.75	GO:0004984	olfactory receptor activity
0.66	GO:0004930	G-protein coupled receptor activity
0.47	GO:0005549	odorant binding

0.52	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O95222|OR6A2_HUMAN
Olfactory receptor 6A2
Search

0.44	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity
0.38	GO:0005549	odorant binding

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O95229|ZWINT_HUMAN
ZW10 interactor
Search

ZWINT

0.97	ZW10 interacting kinetochore protein

0.80	GO:0007093	mitotic cell cycle checkpoint
0.60	GO:0000070	mitotic sister chromatid segregation
0.54	GO:0051649	establishment of localization in cell
0.40	GO:0051301	cell division
0.38	GO:0007062	sister chromatid cohesion

0.64

GO:0047485

protein N-terminus binding

0.78	GO:0000776	kinetochore
0.60	GO:0016604	nuclear body
0.54	GO:0005829	cytosol
0.44	GO:0000779	condensed chromosome, centromeric region
0.42	GO:0030425	dendrite

sp|O95231|VENTX_HUMAN
Homeobox protein VENTX
Search

VENTX

0.97	Homeobox protein VENTX

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:0007275	multicellular organism development
0.47	GO:0051254	positive regulation of RNA metabolic process
0.46	GO:0010557	positive regulation of macromolecule biosynthetic process
0.46	GO:0031328	positive regulation of cellular biosynthetic process
0.41	GO:0060322	head development
0.39	GO:0045165	cell fate commitment
0.37	GO:0042755	eating behavior

0.64	GO:0043565	sequence-specific DNA binding
0.45	GO:0003700	DNA binding transcription factor activity
0.35	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.36	GO:0005667	transcription factor complex
0.34	GO:0005829	cytosol
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|O95232|LC7L3_HUMAN
Luc7-like protein 3
Search

LUC7L3

0.96	Cisplatin resistance-associated overexpressed protein

0.83

GO:0006376

mRNA splice site selection

0.76	GO:0003729	mRNA binding
0.34	GO:0003677	DNA binding
0.34	GO:0005515	protein binding

0.82	GO:0005685	U1 snRNP
0.54	GO:0016607	nuclear speck
0.49	GO:0071004	U2-type prespliceosome

sp|O95235|KI20A_HUMAN
Kinesin-like protein KIF20A
Search

sp|O95236|APOL3_HUMAN
Apolipoprotein L3
Search

APOL1

0.90	Apolipoprotein L-I

0.75	GO:0042157	lipoprotein metabolic process
0.74	GO:0006869	lipid transport
0.38	GO:0006954	inflammatory response
0.37	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.36	GO:0008203	cholesterol metabolic process
0.35	GO:0060135	maternal process involved in female pregnancy
0.34	GO:0043687	post-translational protein modification
0.34	GO:0007165	signal transduction
0.34	GO:0031640	killing of cells of other organism
0.34	GO:0045087	innate immune response

0.72	GO:0008289	lipid binding
0.36	GO:0005319	lipid transporter activity
0.35	GO:0008035	high-density lipoprotein particle binding
0.35	GO:0004871	signal transducer activity
0.34	GO:0005515	protein binding
0.34	GO:0005254	chloride channel activity

0.66	GO:0005576	extracellular region
0.36	GO:0043231	intracellular membrane-bounded organelle
0.35	GO:1990777	lipoprotein particle
0.35	GO:0012505	endomembrane system
0.34	GO:0005737	cytoplasm
0.33	GO:0031984	organelle subcompartment
0.33	GO:0043233	organelle lumen
0.30	GO:0016020	membrane

sp|O95237|LRAT_HUMAN
Lecithin retinol acyltransferase
Search

LRAT

0.92	Lecithin retinol acyltransferase b (phosphatidylcholine-retinol O-acyltransferase)

0.64	GO:0042572	retinol metabolic process
0.63	GO:0006776	vitamin A metabolic process
0.61	GO:0032370	positive regulation of lipid transport
0.60	GO:1990830	cellular response to leukemia inhibitory factor
0.42	GO:0042573	retinoic acid metabolic process
0.40	GO:0007601	visual perception
0.38	GO:0006653	1,2-diacyl-sn-glycero-3-phosphocholine metabolic process

0.70	GO:0047173	phosphatidylcholine-retinol O-acyltransferase activity
0.47	GO:0102279	lecithin:11-cis retinol acyltransferase activity
0.43	GO:0019841	retinol binding
0.43	GO:0001972	retinoic acid binding
0.37	GO:0016416	O-palmitoyltransferase activity

0.43	GO:0005771	multivesicular body
0.42	GO:0005791	rough endoplasmic reticulum
0.42	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.70

EC:2.3.1.135

GO:0047173

sp|O95238|SPDEF_HUMAN
SAM pointed domain-containing Ets transcription factor
Search

SPDEF

0.97	SAM pointed domain-containing Ets transcription factor

0.63	GO:0060480	lung goblet cell differentiation
0.62	GO:0060576	intestinal epithelial cell development
0.62	GO:0010455	positive regulation of cell fate commitment
0.61	GO:0010454	negative regulation of cell fate commitment
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0043065	positive regulation of apoptotic process
0.52	GO:0051254	positive regulation of RNA metabolic process
0.52	GO:0010557	positive regulation of macromolecule biosynthetic process

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity

0.61

GO:0005634

nucleus

sp|O95239|KIF4A_HUMAN
Chromosome-associated kinesin KIF4A
Search

KIF4A

0.95	Kinesin family member 4

0.74	GO:0007018	microtubule-based movement
0.49	GO:0051256	mitotic spindle midzone assembly
0.46	GO:0000281	mitotic cytokinesis
0.38	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.37	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.35	GO:0030705	cytoskeleton-dependent intracellular transport
0.34	GO:0006629	lipid metabolic process
0.33	GO:0022008	neurogenesis
0.33	GO:0030030	cell projection organization

0.74	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0042623	ATPase activity, coupled
0.36	GO:0008889	glycerophosphodiester phosphodiesterase activity
0.35	GO:0003677	DNA binding

0.49	GO:0005871	kinesin complex
0.46	GO:0045171	intercellular bridge
0.44	GO:0030496	midbody
0.42	GO:0005874	microtubule
0.42	GO:0005654	nucleoplasm
0.38	GO:0016363	nuclear matrix
0.37	GO:0005694	chromosome
0.37	GO:0005829	cytosol
0.36	GO:1904115	axon cytoplasm
0.35	GO:0005819	spindle

0.36

EC:3.1.4.46

GO:0008889

sp|O95243|MBD4_HUMAN
Methyl-CpG-binding domain protein 4
Search

MBD4

0.92	Methyl-CpG-binding domain protein 4

0.65	GO:0006281	DNA repair
0.47	GO:0009314	response to radiation
0.39	GO:0032355	response to estradiol
0.38	GO:0009223	pyrimidine deoxyribonucleotide catabolic process
0.38	GO:0007095	mitotic G2 DNA damage checkpoint
0.37	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
0.37	GO:0006304	DNA modification
0.34	GO:0043414	macromolecule methylation
0.32	GO:0006751	glutathione catabolic process
0.32	GO:0006508	proteolysis

0.85	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity
0.54	GO:0003677	DNA binding
0.35	GO:0004520	endodeoxyribonuclease activity
0.34	GO:0005515	protein binding
0.33	GO:0036374	glutathione hydrolase activity
0.32	GO:0005509	calcium ion binding

0.58	GO:0016607	nuclear speck
0.45	GO:0000785	chromatin
0.33	GO:0005737	cytoplasm

0.33	EC:3.4.19.13	GO:0036374
0.33	KEGG:R00494	GO:0036374

sp|O95248|MTMR5_HUMAN
Myotubularin-related protein 5
Search

SBF1

0.92	SET binding factor 1

0.75	GO:0043087	regulation of GTPase activity
0.54	GO:0007283	spermatogenesis

0.79	GO:0019208	phosphatase regulator activity
0.56	GO:0017112	Rab guanyl-nucleotide exchange factor activity

0.54	GO:0016604	nuclear body
0.39	GO:0005737	cytoplasm

sp|O95249|GOSR1_HUMAN
Golgi SNAP receptor complex member 1
Search

GOSR1

0.73	Golgi SNAP receptor complex member 1

0.76	GO:0006888	ER to Golgi vesicle-mediated transport
0.58	GO:0015031	protein transport
0.50	GO:0042147	retrograde transport, endosome to Golgi
0.49	GO:0048209	regulation of vesicle targeting, to, from or within Golgi
0.48	GO:0061025	membrane fusion
0.46	GO:0006891	intra-Golgi vesicle-mediated transport
0.46	GO:0048284	organelle fusion
0.45	GO:0016050	vesicle organization

0.53	GO:0005484	SNAP receptor activity
0.46	GO:0000149	SNARE binding

0.80	GO:0005801	cis-Golgi network
0.72	GO:0000139	Golgi membrane
0.48	GO:0005797	Golgi medial cisterna
0.46	GO:0031201	SNARE complex
0.45	GO:0005829	cytosol
0.35	GO:0000138	Golgi trans cisterna
0.34	GO:0030133	transport vesicle
0.30	GO:0031224	intrinsic component of membrane

sp|O95251|KAT7_HUMAN
Histone acetyltransferase KAT7
Search

KAT7

0.55	Histone acetyltransferase

0.78	GO:0016573	histone acetylation
0.61	GO:0072739	response to anisomycin
0.61	GO:0072720	response to dithiothreitol
0.60	GO:0072708	response to sorbitol
0.60	GO:0072716	response to actinomycin D
0.60	GO:0090240	positive regulation of histone H4 acetylation
0.59	GO:0072710	response to hydroxyurea
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:0010468	regulation of gene expression

0.80	GO:0004402	histone acetyltransferase activity
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.53	GO:0003688	DNA replication origin binding
0.52	GO:0044212	transcription regulatory region DNA binding
0.33	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.52	GO:0031248	protein acetyltransferase complex
0.49	GO:0005829	cytosol
0.48	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.34	GO:0043232	intracellular non-membrane-bounded organelle

0.80

GO:0004402

sp|O95255|MRP6_HUMAN
Multidrug resistance-associated protein 6
Search

ABCC6

0.72	Multidrug resistance-associated protein 6

0.55	GO:0055085	transmembrane transport
0.42	GO:0030500	regulation of bone mineralization
0.40	GO:0043009	chordate embryonic development
0.36	GO:0071585	detoxification of cadmium ion
0.36	GO:0042493	response to drug
0.36	GO:0007601	visual perception
0.35	GO:0099133	ATP hydrolysis coupled anion transmembrane transport
0.34	GO:0034635	glutathione transport
0.34	GO:0042908	xenobiotic transport

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0034634	glutathione transmembrane transporter activity
0.34	GO:0042910	xenobiotic transmembrane transporter activity
0.34	GO:0015238	drug transmembrane transporter activity

0.43	GO:0016323	basolateral plasma membrane
0.42	GO:0005634	nucleus
0.40	GO:0016328	lateral plasma membrane
0.39	GO:0016324	apical plasma membrane
0.38	GO:0005887	integral component of plasma membrane
0.35	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0005856	cytoskeleton

sp|O95256|I18RA_HUMAN
Interleukin-18 receptor accessory protein
Search

IL18RAP

0.97	interleukin-18 receptor accessory protein isoform X1

0.72	GO:0019221	cytokine-mediated signaling pathway
0.70	GO:0035744	T-helper 1 cell cytokine production
0.70	GO:0071351	cellular response to interleukin-18
0.69	GO:0032635	interleukin-6 production
0.68	GO:0032609	interferon-gamma production
0.68	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
0.66	GO:0042119	neutrophil activation
0.61	GO:0008283	cell proliferation
0.45	GO:0070301	cellular response to hydrogen peroxide
0.38	GO:0006954	inflammatory response

0.68	GO:0004908	interleukin-1 receptor activity
0.39	GO:0042007	interleukin-18 binding
0.34	GO:0002113	interleukin-33 binding
0.34	GO:0002114	interleukin-33 receptor activity

0.35	GO:0005886	plasma membrane
0.33	GO:0005578	proteinaceous extracellular matrix
0.33	GO:0009986	cell surface
0.33	GO:0098552	side of membrane
0.30	GO:0016021	integral component of membrane

sp|O95257|GA45G_HUMAN
Growth arrest and DNA damage-inducible protein GADD45 gamma
Search

GADD45G

0.96	Growth arrest and DNA damage inducible gamma

0.73	GO:0051726	regulation of cell cycle
0.62	GO:1900745	positive regulation of p38MAPK cascade
0.62	GO:0006950	response to stress
0.62	GO:0000185	activation of MAPKKK activity
0.60	GO:0046330	positive regulation of JNK cascade
0.56	GO:0043065	positive regulation of apoptotic process
0.46	GO:0071260	cellular response to mechanical stimulus
0.46	GO:0071479	cellular response to ionizing radiation
0.46	GO:2000379	positive regulation of reactive oxygen species metabolic process
0.45	GO:0006469	negative regulation of protein kinase activity

0.46	GO:0047485	protein N-terminus binding
0.46	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
0.44	GO:0019900	kinase binding
0.43	GO:0042802	identical protein binding
0.43	GO:0046982	protein heterodimerization activity
0.33	GO:0017056	structural constituent of nuclear pore
0.33	GO:0003735	structural constituent of ribosome

0.61	GO:0005634	nucleus
0.41	GO:0005737	cytoplasm
0.41	GO:0043233	organelle lumen
0.38	GO:0044446	intracellular organelle part
0.34	GO:0030529	intracellular ribonucleoprotein complex
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0012505	endomembrane system
0.32	GO:0031975	envelope
0.32	GO:0043234	protein complex

sp|O95258|UCP5_HUMAN
Brain mitochondrial carrier protein 1
Search

SLC25A14

0.89	Component of oligomeric golgi complex 3

0.77	GO:0006839	mitochondrial transport
0.41	GO:0055085	transmembrane transport
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0009060	aerobic respiration
0.33	GO:0015992	proton transport

0.39	GO:0022857	transmembrane transporter activity
0.34	GO:0004930	G-protein coupled receptor activity
0.33	GO:0005515	protein binding

0.62	GO:0031966	mitochondrial membrane
0.59	GO:0019866	organelle inner membrane
0.33	GO:0005887	integral component of plasma membrane

sp|O95259|KCNH1_HUMAN
Potassium voltage-gated channel subfamily H member 1
Search

KCNH1

0.91	Potassium voltage-gated channel subfamily H member 1

0.72	GO:0034765	regulation of ion transmembrane transport
0.72	GO:0071805	potassium ion transmembrane transport
0.63	GO:0023014	signal transduction by protein phosphorylation
0.60	GO:0000160	phosphorelay signal transduction system
0.50	GO:0021576	hindbrain formation
0.47	GO:0001756	somitogenesis
0.46	GO:0042391	regulation of membrane potential
0.46	GO:0071277	cellular response to calcium ion
0.45	GO:0048015	phosphatidylinositol-mediated signaling
0.43	GO:0042127	regulation of cell proliferation

0.76	GO:0005249	voltage-gated potassium channel activity
0.63	GO:0000155	phosphorelay sensor kinase activity
0.45	GO:1902936	phosphatidylinositol bisphosphate binding
0.42	GO:0005516	calmodulin binding
0.41	GO:0071889	14-3-3 protein binding
0.40	GO:0030551	cyclic nucleotide binding
0.40	GO:0044325	ion channel binding
0.39	GO:0019901	protein kinase binding
0.38	GO:0046982	protein heterodimerization activity
0.38	GO:0042802	identical protein binding

0.64	GO:0005887	integral component of plasma membrane
0.46	GO:0031901	early endosome membrane
0.44	GO:0034705	potassium channel complex
0.43	GO:0042734	presynaptic membrane
0.43	GO:0005637	nuclear inner membrane
0.43	GO:0009986	cell surface
0.42	GO:0043025	neuronal cell body
0.42	GO:0030425	dendrite
0.42	GO:0030424	axon
0.41	GO:0014069	postsynaptic density

0.63

EC:2.7.3

GO:0000155

sp|O95260|ATE1_HUMAN
Arginyl-tRNA--protein transferase 1
Search

ATE1

0.80	Arginyl-tRNA--protein transferase 1

0.80	GO:0016598	protein arginylation
0.50	GO:0010498	proteasomal protein catabolic process
0.32	GO:0006281	DNA repair

0.81	GO:0004057	arginyltransferase activity
0.35	GO:0005515	protein binding

0.44	GO:0005634	nucleus
0.39	GO:0005737	cytoplasm
0.33	GO:0030915	Smc5-Smc6 complex

0.81

EC:2.3.2.8

GO:0004057

sp|O95263|PDE8B_HUMAN
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Search

PDE8B

0.56	Phosphodiesterase

0.60	GO:0007165	signal transduction
0.39	GO:0031323	regulation of cellular metabolic process
0.39	GO:0080090	regulation of primary metabolic process
0.38	GO:0046676	negative regulation of insulin secretion
0.38	GO:0009889	regulation of biosynthetic process
0.38	GO:0060255	regulation of macromolecule metabolic process
0.38	GO:0051171	regulation of nitrogen compound metabolic process
0.38	GO:1903206	negative regulation of hydrogen peroxide-induced cell death
0.38	GO:0071364	cellular response to epidermal growth factor stimulus
0.36	GO:1902533	positive regulation of intracellular signal transduction

0.79	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.54	GO:0046872	metal ion binding
0.36	GO:0019900	kinase binding

0.34	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.79

GO:0004114

sp|O95264|5HT3B_HUMAN
5-hydroxytryptamine receptor 3B
Search

HTR3B

0.97	5-hydroxytryptamine (Serotonin) receptor 3B

0.60	GO:0007165	signal transduction
0.60	GO:0034220	ion transmembrane transport
0.49	GO:0006812	cation transport
0.38	GO:0007268	chemical synaptic transmission
0.37	GO:0032414	positive regulation of ion transmembrane transporter activity
0.36	GO:0071363	cellular response to growth factor stimulus
0.34	GO:0043043	peptide biosynthetic process
0.34	GO:0060078	regulation of postsynaptic membrane potential
0.33	GO:0044267	cellular protein metabolic process
0.33	GO:0010467	gene expression

0.74	GO:0005230	extracellular ligand-gated ion channel activity
0.70	GO:0004888	transmembrane signaling receptor activity
0.60	GO:0022835	transmitter-gated channel activity
0.59	GO:0140135	mechanosensitive cation channel activity
0.34	GO:0003735	structural constituent of ribosome
0.34	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

0.76	GO:0045211	postsynaptic membrane
0.69	GO:1904602	serotonin-activated cation-selective channel complex
0.58	GO:0009986	cell surface
0.53	GO:0005887	integral component of plasma membrane
0.36	GO:0043025	neuronal cell body
0.36	GO:0030424	axon
0.34	GO:0005840	ribosome

sp|O95267|GRP1_HUMAN
RAS guanyl-releasing protein 1
Search

RASGRP1

0.97	RAS guanyl releasing protein 1 (Calcium and DAG-regulated)

0.77	GO:0007265	Ras protein signal transduction
0.71	GO:0043547	positive regulation of GTPase activity
0.58	GO:0032252	secretory granule localization
0.58	GO:1902715	positive regulation of interferon-gamma secretion
0.57	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
0.57	GO:0032825	positive regulation of natural killer cell differentiation
0.57	GO:0033089	positive regulation of T cell differentiation in thymus
0.56	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
0.56	GO:0002279	mast cell activation involved in immune response
0.56	GO:0002448	mast cell mediated immunity

0.75	GO:0005085	guanyl-nucleotide exchange factor activity
0.72	GO:0005096	GTPase activator activity
0.69	GO:0005509	calcium ion binding
0.56	GO:0031210	phosphatidylcholine binding
0.56	GO:0001786	phosphatidylserine binding
0.55	GO:0019992	diacylglycerol binding
0.50	GO:0017016	Ras GTPase binding
0.50	GO:0042803	protein homodimerization activity
0.45	GO:0008270	zinc ion binding
0.32	GO:0003677	DNA binding

0.56	GO:0042629	mast cell granule
0.49	GO:0005794	Golgi apparatus
0.49	GO:0005829	cytosol
0.43	GO:0005886	plasma membrane
0.39	GO:0005789	endoplasmic reticulum membrane
0.38	GO:0098588	bounding membrane of organelle
0.30	GO:0016021	integral component of membrane

sp|O95271|TNKS1_HUMAN
Tankyrase-1
Search

0.47	Poly [ADP-ribose] polymerase

0.85	GO:0032212	positive regulation of telomere maintenance via telomerase
0.82	GO:0051225	spindle assembly
0.77	GO:0016055	Wnt signaling pathway
0.49	GO:1904743	negative regulation of telomeric DNA binding
0.49	GO:1904908	negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric
0.49	GO:0070213	protein auto-ADP-ribosylation
0.49	GO:0070212	protein poly-ADP-ribosylation
0.48	GO:0070198	protein localization to chromosome, telomeric region
0.48	GO:1904355	positive regulation of telomere capping
0.47	GO:0051973	positive regulation of telomerase activity

0.82	GO:0003950	NAD+ ADP-ribosyltransferase activity
0.45	GO:0042393	histone binding
0.40	GO:0008270	zinc ion binding
0.32	GO:0003676	nucleic acid binding

0.47	GO:0097431	mitotic spindle pole
0.45	GO:0000784	nuclear chromosome, telomeric region
0.45	GO:0031965	nuclear membrane
0.44	GO:0016604	nuclear body
0.42	GO:0005794	Golgi apparatus
0.41	GO:0005829	cytosol
0.34	GO:0000242	pericentriolar material
0.33	GO:0005643	nuclear pore
0.33	GO:0000775	chromosome, centromeric region
0.33	GO:0098588	bounding membrane of organelle

0.82

EC:2.4.2.30

GO:0003950

sp|O95273|CCDB1_HUMAN
Cyclin-D1-binding protein 1
Search

CCNDBP1

0.97	Cyclin D-type binding-protein 1

0.73

GO:0051726

regulation of cell cycle

0.63

GO:0005654

nucleoplasm

sp|O95274|LYPD3_HUMAN
Ly6/PLAUR domain-containing protein 3
Search

LYPD3

0.97	Ly6/PLAUR domain-containing protein 3

0.79	GO:0007160	cell-matrix adhesion
0.51	GO:0006501	C-terminal protein lipidation

0.85

GO:0043236

laminin binding

0.58	GO:0031225	anchored component of membrane
0.53	GO:0005886	plasma membrane
0.50	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane

sp|O95279|KCNK5_HUMAN
Potassium channel subfamily K member 5
Search

KCNK5

0.97	Potassium two pore domain channel subfamily K member 5

0.72	GO:0071805	potassium ion transmembrane transport
0.52	GO:0030322	stabilization of membrane potential
0.39	GO:0033334	fin morphogenesis
0.36	GO:0007588	excretion
0.35	GO:0034765	regulation of ion transmembrane transport

0.75	GO:0005267	potassium channel activity
0.54	GO:0022843	voltage-gated cation channel activity
0.52	GO:0022842	narrow pore channel activity
0.31	GO:0003676	nucleic acid binding

0.44	GO:0005887	integral component of plasma membrane
0.31	GO:0005737	cytoplasm

sp|O95292|VAPB_HUMAN
Vesicle-associated membrane protein-associated protein B/C
Search

VAPB

0.90	Vesicle-associated membrane protein-associated protein B

0.75	GO:0030968	endoplasmic reticulum unfolded protein response
0.72	GO:0006874	cellular calcium ion homeostasis
0.48	GO:0045070	positive regulation of viral genome replication
0.46	GO:0090114	COPII-coated vesicle budding
0.46	GO:0032075	positive regulation of nuclease activity
0.45	GO:0007029	endoplasmic reticulum organization
0.45	GO:0044828	negative regulation by host of viral genome replication
0.45	GO:0044789	modulation by host of viral release from host cell
0.44	GO:1902188	positive regulation of viral release from host cell
0.44	GO:0044794	positive regulation by host of viral process

0.54	GO:0033149	FFAT motif binding
0.46	GO:0045296	cadherin binding
0.45	GO:0048487	beta-tubulin binding
0.44	GO:0008017	microtubule binding
0.44	GO:0046982	protein heterodimerization activity
0.43	GO:0042803	protein homodimerization activity
0.42	GO:0019899	enzyme binding

0.71	GO:0005789	endoplasmic reticulum membrane
0.65	GO:0005794	Golgi apparatus
0.43	GO:0098588	bounding membrane of organelle
0.39	GO:0070971	endoplasmic reticulum exit site
0.38	GO:0005923	bicellular tight junction
0.37	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0031982	vesicle
0.35	GO:0015630	microtubule cytoskeleton
0.35	GO:0031965	nuclear membrane
0.34	GO:0005886	plasma membrane

sp|O95294|RASL1_HUMAN
RasGAP-activating-like protein 1
Search

RASAL1

0.95	RAS protein activator like 1

0.82	GO:0046580	negative regulation of Ras protein signal transduction
0.79	GO:0071277	cellular response to calcium ion
0.74	GO:0043087	regulation of GTPase activity
0.73	GO:0051345	positive regulation of hydrolase activity
0.64	GO:1903861	positive regulation of dendrite extension
0.61	GO:0035556	intracellular signal transduction
0.36	GO:0051346	negative regulation of hydrolase activity
0.34	GO:0023014	signal transduction by protein phosphorylation

0.74	GO:0005096	GTPase activator activity
0.74	GO:0005543	phospholipid binding
0.33	GO:0046872	metal ion binding

0.52	GO:0005829	cytosol
0.51	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O95295|SNAPN_HUMAN
SNARE-associated protein Snapin
Search

SNAPIN

0.97	SNARE-associated protein Snapin

0.69	GO:0006886	intracellular protein transport
0.61	GO:1902774	late endosome to lysosome transport
0.61	GO:0072553	terminal button organization
0.61	GO:0007042	lysosomal lumen acidification
0.60	GO:0099500	vesicle fusion to plasma membrane
0.60	GO:0008090	retrograde axonal transport
0.60	GO:0048490	anterograde synaptic vesicle transport
0.59	GO:0016188	synaptic vesicle maturation
0.59	GO:0032418	lysosome localization
0.59	GO:0008333	endosome to lysosome transport

0.56	GO:0000149	SNARE binding
0.35	GO:0001784	phosphotyrosine residue binding
0.34	GO:0008276	protein methyltransferase activity
0.34	GO:0004842	ubiquitin-protein transferase activity
0.34	GO:0003700	DNA binding transcription factor activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
0.33	GO:0003676	nucleic acid binding
0.33	GO:0004871	signal transducer activity
0.33	GO:0016874	ligase activity

0.83	GO:0031083	BLOC-1 complex
0.69	GO:0030672	synaptic vesicle membrane
0.61	GO:0099078	BORC complex
0.58	GO:1904115	axon cytoplasm
0.55	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0005765	lysosomal membrane
0.39	GO:0030141	secretory granule
0.38	GO:0030054	cell junction
0.38	GO:0000139	Golgi membrane
0.35	GO:0005667	transcription factor complex

0.34	EC:2.1.1	GO:0008276
0.34	KEGG:R03876	GO:0004842

sp|O95297|MPZL1_HUMAN
Myelin protein zero-like protein 1
Search

MPZL1

0.97	Myelin protein zero like 1

0.58	GO:0007165	signal transduction
0.45	GO:0098743	cell aggregation
0.44	GO:0042552	myelination
0.42	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules
0.39	GO:0060028	convergent extension involved in axis elongation
0.36	GO:0007267	cell-cell signaling
0.35	GO:0045217	cell-cell junction maintenance
0.35	GO:0043066	negative regulation of apoptotic process

0.35	GO:0005515	protein binding
0.34	GO:0005198	structural molecule activity

0.66	GO:0005887	integral component of plasma membrane
0.48	GO:0043209	myelin sheath
0.38	GO:0005925	focal adhesion
0.37	GO:0009986	cell surface
0.35	GO:0016323	basolateral plasma membrane
0.35	GO:0005791	rough endoplasmic reticulum
0.35	GO:0005764	lysosome

sp|O95298|NDUC2_HUMAN
NADH dehydrogenase [ubiquinone] 1 subunit C2
Search

NDUFC2

0.90	Potassium channel tetramerization domain containing 14

0.75	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
0.50	GO:0032981	mitochondrial respiratory chain complex I assembly
0.41	GO:2001171	positive regulation of ATP biosynthetic process
0.41	GO:0010918	positive regulation of mitochondrial membrane potential
0.40	GO:1901223	negative regulation of NIK/NF-kappaB signaling
0.40	GO:0060547	negative regulation of necrotic cell death
0.40	GO:1903427	negative regulation of reactive oxygen species biosynthetic process
0.39	GO:0050727	regulation of inflammatory response
0.38	GO:0043312	neutrophil degranulation
0.35	GO:0043413	macromolecule glycosylation

0.69	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.35	GO:0016758	transferase activity, transferring hexosyl groups

0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane
0.60	GO:0070469	respiratory chain
0.48	GO:0030964	NADH dehydrogenase complex
0.46	GO:0098798	mitochondrial protein complex
0.44	GO:1990204	oxidoreductase complex
0.42	GO:0098796	membrane protein complex
0.39	GO:0035577	azurophil granule membrane
0.35	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0005886	plasma membrane

0.69

GO:0008137

sp|O95299|NDUAA_HUMAN
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Search

NDUFA10

0.89	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

0.74	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
0.56	GO:0032981	mitochondrial respiratory chain complex I assembly
0.34	GO:0042221	response to chemical
0.34	GO:0009165	nucleotide biosynthetic process
0.33	GO:0007608	sensory perception of smell
0.33	GO:0050906	detection of stimulus involved in sensory perception
0.33	GO:0007186	G-protein coupled receptor signaling pathway

0.46	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.35	GO:0019206	nucleoside kinase activity
0.33	GO:0004984	olfactory receptor activity
0.33	GO:0004930	G-protein coupled receptor activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.81	GO:0005747	mitochondrial respiratory chain complex I
0.69	GO:0005759	mitochondrial matrix
0.51	GO:0043209	myelin sheath
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.46

GO:0008137

sp|O95302|FKBP9_HUMAN
Peptidyl-prolyl cis-trans isomerase FKBP9
Search

0.10	Peptidyl-prolyl cis-trans isomerase FKBP9

0.30	GO:0044260	cellular macromolecule metabolic process
0.30	GO:0006807	nitrogen compound metabolic process
0.30	GO:0043412	macromolecule modification
0.30	GO:0061077	chaperone-mediated protein folding
0.30	GO:0044238	primary metabolic process

0.30	GO:0016853	isomerase activity
0.30	GO:0140096	catalytic activity, acting on a protein
0.30	GO:0097159	organic cyclic compound binding
0.30	GO:0043167	ion binding
0.30	GO:0008144	drug binding
0.30	GO:1901363	heterocyclic compound binding

0.30

GO:0005783

endoplasmic reticulum

0.30

EC:5

GO:0016853

sp|O95319|CELF2_HUMAN
CUGBP Elav-like family member 2
Search

CELF2

0.92	cDNA FLJ56893, highly similar to Homo sapiens CUG triplet repeat, RNA binding protein 2 (CUGBP2), transcript variant 3, mRNA

0.50	GO:0006376	mRNA splice site selection
0.35	GO:0000380	alternative mRNA splicing, via spliceosome
0.35	GO:0008016	regulation of heart contraction
0.34	GO:0017148	negative regulation of translation

0.59	GO:0003723	RNA binding
0.35	GO:0000900	translation repressor activity, nucleic acid binding
0.32	GO:1901265	nucleoside phosphate binding
0.32	GO:0036094	small molecule binding

0.43	GO:0005634	nucleus
0.38	GO:0005737	cytoplasm
0.33	GO:0019013	viral nucleocapsid
0.32	GO:0030529	intracellular ribonucleoprotein complex

sp|O95336|6PGL_HUMAN
6-phosphogluconolactonase
Search

PGLS

0.43	6-phosphogluconolactonase

0.72	GO:0006098	pentose-phosphate shunt
0.60	GO:0005975	carbohydrate metabolic process
0.33	GO:0015908	fatty acid transport
0.33	GO:0001676	long-chain fatty acid metabolic process

0.80	GO:0017057	6-phosphogluconolactonase activity
0.35	GO:0048029	monosaccharide binding
0.34	GO:0015245	fatty acid transmembrane transporter activity
0.34	GO:0031957	very long-chain fatty acid-CoA ligase activity
0.34	GO:0005515	protein binding
0.33	GO:0004467	long-chain fatty acid-CoA ligase activity
0.32	GO:0016757	transferase activity, transferring glycosyl groups
0.32	GO:0003676	nucleic acid binding

0.37	GO:0070062	extracellular exosome
0.37	GO:0005737	cytoplasm
0.33	GO:0000178	exosome (RNase complex)
0.30	GO:0016020	membrane

0.80	EC:3.1.1.31	GO:0017057
0.80	KEGG:R02035	GO:0017057

sp|O95340|PAPS2_HUMAN
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Search

PAPSS2

0.96	LOW QUALITY PROTEIN: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

0.76	GO:0000103	sulfate assimilation
0.57	GO:0016310	phosphorylation
0.52	GO:0060348	bone development
0.51	GO:0007596	blood coagulation
0.51	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
0.34	GO:0070814	hydrogen sulfide biosynthetic process

0.80	GO:0004020	adenylylsulfate kinase activity
0.79	GO:0004781	sulfate adenylyltransferase (ATP) activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0098616	selenate adenylyltransferase (ATP) activity
0.34	GO:0042803	protein homodimerization activity

0.35

GO:0005829

cytosol

0.80

EC:2.7.1.25

GO:0004020

sp|O95342|ABCBB_HUMAN
Bile salt export pump
Search

ABCB11

0.90	Bile salt export pump

0.79	GO:0015721	bile acid and bile salt transport
0.55	GO:0055085	transmembrane transport
0.42	GO:0046717	acid secretion
0.39	GO:0006699	bile acid biosynthetic process
0.38	GO:0043627	response to estrogen
0.37	GO:0046618	drug export
0.36	GO:0006814	sodium ion transport
0.36	GO:0042908	xenobiotic transport
0.36	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.36	GO:0006979	response to oxidative stress

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0015126	canalicular bile acid transmembrane transporter activity
0.36	GO:0015081	sodium ion transmembrane transporter activity
0.36	GO:0042910	xenobiotic transmembrane transporter activity
0.36	GO:0022853	active ion transmembrane transporter activity
0.36	GO:0015238	drug transmembrane transporter activity

0.48	GO:0046581	intercellular canaliculus
0.45	GO:0045177	apical part of cell
0.40	GO:0070062	extracellular exosome
0.37	GO:0044459	plasma membrane part
0.36	GO:0000139	Golgi membrane
0.30	GO:0016021	integral component of membrane

sp|O95343|SIX3_HUMAN
Homeobox protein SIX3
Search

SIX3

0.94	SIX homeobox 3

0.80	GO:0001654	eye development
0.70	GO:0006357	regulation of transcription by RNA polymerase II
0.69	GO:0007420	brain development
0.63	GO:0097402	neuroblast migration
0.62	GO:1990086	lens fiber cell apoptotic process
0.61	GO:0009946	proximal/distal axis specification
0.61	GO:0061074	regulation of neural retina development
0.60	GO:0006366	transcription by RNA polymerase II
0.60	GO:0002070	epithelial cell maturation
0.60	GO:0014016	neuroblast differentiation

0.73	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.61	GO:0001222	transcription corepressor binding
0.58	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.58	GO:0042826	histone deacetylase binding
0.55	GO:0003713	transcription coactivator activity
0.38	GO:0005102	receptor binding

0.61

GO:0005634

nucleus

sp|O95347|SMC2_HUMAN
Structural maintenance of chromosomes protein 2
Search

sp|O95352|ATG7_HUMAN
Ubiquitin-like modifier-activating enzyme ATG7
Search

ATG7

0.78	Autophagy-related protein 7

0.77	GO:0006914	autophagy
0.71	GO:0071455	cellular response to hyperoxia
0.69	GO:0061726	mitochondrion disassembly
0.64	GO:0009267	cellular response to starvation
0.64	GO:0006497	protein lipidation
0.64	GO:0045732	positive regulation of protein catabolic process
0.63	GO:0043065	positive regulation of apoptotic process
0.62	GO:0051607	defense response to virus
0.61	GO:0031401	positive regulation of protein modification process
0.61	GO:0039521	suppression by virus of host autophagy

0.76	GO:0008641	ubiquitin-like modifier activating enzyme activity
0.61	GO:0042803	protein homodimerization activity
0.59	GO:0008134	transcription factor binding
0.39	GO:0016740	transferase activity

0.52

GO:0000407

phagophore assembly site

0.39

EC:2

GO:0016740

sp|O95359|TACC2_HUMAN
Transforming acidic coiled-coil-containing protein 2
Search

TACC2

0.76	Transforming acidic coiled-coil-containing protein 2

0.71	GO:0021987	cerebral cortex development
0.67	GO:0008283	cell proliferation
0.64	GO:0000226	microtubule cytoskeleton organization
0.53	GO:0007097	nuclear migration
0.51	GO:0032886	regulation of microtubule-based process
0.49	GO:0022008	neurogenesis
0.48	GO:0097435	supramolecular fiber organization
0.47	GO:0022402	cell cycle process

0.75	GO:0035257	nuclear hormone receptor binding
0.49	GO:0019904	protein domain specific binding

0.67	GO:0005654	nucleoplasm
0.66	GO:0005829	cytosol
0.57	GO:0015630	microtubule cytoskeleton
0.54	GO:0005886	plasma membrane
0.46	GO:0044430	cytoskeletal part

sp|O95361|TRI16_HUMAN
Tripartite motif-containing protein 16
Search

TRIM16

0.87	Tripartite motif-containing protein 16

0.45	GO:0048386	positive regulation of retinoic acid receptor signaling pathway
0.44	GO:0045618	positive regulation of keratinocyte differentiation
0.44	GO:0050718	positive regulation of interleukin-1 beta secretion
0.43	GO:0060416	response to growth hormone
0.43	GO:0043966	histone H3 acetylation
0.43	GO:0043967	histone H4 acetylation
0.42	GO:0032526	response to retinoic acid
0.41	GO:0046683	response to organophosphorus
0.40	GO:0045893	positive regulation of transcription, DNA-templated
0.32	GO:0016567	protein ubiquitination

0.62	GO:0008270	zinc ion binding
0.46	GO:0032089	NACHT domain binding
0.44	GO:0019966	interleukin-1 binding
0.36	GO:0003677	DNA binding
0.36	GO:0016874	ligase activity
0.32	GO:0032550	purine ribonucleoside binding
0.32	GO:0032561	guanyl ribonucleotide binding
0.32	GO:0004842	ubiquitin-protein transferase activity
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0005622	intracellular
0.39	GO:0031974	membrane-enclosed lumen
0.37	GO:0005886	plasma membrane
0.36	GO:0044422	organelle part
0.36	GO:0043227	membrane-bounded organelle

0.36	EC:6	GO:0016874
0.32	KEGG:R03876	GO:0004842

sp|O95363|SYFM_HUMAN
Phenylalanine--tRNA ligase, mitochondrial
Search

FARS2

0.71	Phenylalanyl-tRNA synthetase

0.76	GO:0006432	phenylalanyl-tRNA aminoacylation
0.46	GO:0008033	tRNA processing

0.76	GO:0004826	phenylalanine-tRNA ligase activity
0.69	GO:0000049	tRNA binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding

0.49	GO:0005737	cytoplasm
0.42	GO:0043231	intracellular membrane-bounded organelle
0.36	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part

0.76

EC:6.1.1.20

GO:0004826

sp|O95365|ZBT7A_HUMAN
Zinc finger and BTB domain-containing protein 7A
Search

ZBTB7A

0.95	Zinc finger and BTB domain-containing protein 7A

0.54	GO:0000122	negative regulation of transcription by RNA polymerase II
0.47	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding
0.47	GO:0045600	positive regulation of fat cell differentiation
0.45	GO:0008285	negative regulation of cell proliferation
0.43	GO:0045944	positive regulation of transcription by RNA polymerase II
0.39	GO:0030154	cell differentiation
0.39	GO:0007275	multicellular organism development
0.37	GO:0045670	regulation of osteoclast differentiation
0.37	GO:0061448	connective tissue development
0.37	GO:0006351	transcription, DNA-templated

0.59	GO:0035035	histone acetyltransferase binding
0.57	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.55	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.36	GO:0046872	metal ion binding

0.42

GO:0005634

nucleus

sp|O95371|OR2C1_HUMAN
Olfactory receptor 2C1
Search

0.45	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.72	GO:0004930	G-protein coupled receptor activity
0.32	GO:0003676	nucleic acid binding

0.55	GO:0005886	plasma membrane
0.48	GO:0005938	cell cortex
0.30	GO:0031224	intrinsic component of membrane

sp|O95372|LYPA2_HUMAN
Acyl-protein thioesterase 2
Search

LYPLA2

0.87	Acyl-protein thioesterase 2

0.48	GO:0098734	macromolecule depalmitoylation
0.47	GO:0042159	lipoprotein catabolic process
0.45	GO:0035601	protein deacylation
0.40	GO:0006631	fatty acid metabolic process
0.39	GO:0042997	negative regulation of Golgi to plasma membrane protein transport
0.36	GO:0007411	axon guidance
0.36	GO:0050999	regulation of nitric-oxide synthase activity

0.51	GO:0016787	hydrolase activity
0.43	GO:0045296	cadherin binding
0.39	GO:0140096	catalytic activity, acting on a protein

0.42	GO:0005795	Golgi stack
0.40	GO:0070062	extracellular exosome
0.37	GO:0005829	cytosol
0.35	GO:0005739	mitochondrion

0.51

GO:0016787

sp|O95373|IPO7_HUMAN
Importin-7
Search

IPO7

0.89

Importin

0.68	GO:0006886	intracellular protein transport
0.55	GO:0006606	protein import into nucleus
0.51	GO:0045087	innate immune response
0.40	GO:0007165	signal transduction
0.35	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
0.33	GO:0016032	viral process

0.78	GO:0008536	Ran GTPase binding
0.54	GO:0046332	SMAD binding
0.52	GO:0042393	histone binding
0.44	GO:0008565	protein transporter activity
0.34	GO:0030695	GTPase regulator activity
0.32	GO:0003676	nucleic acid binding

0.57	GO:0005634	nucleus
0.48	GO:0005829	cytosol
0.46	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.43	GO:0012505	endomembrane system
0.40	GO:0031975	envelope
0.33	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

sp|O95376|ARI2_HUMAN
E3 ubiquitin-protein ligase ARIH2
Search

ARIH2

0.58	RING-type E3 ubiquitin transferase

0.72	GO:0016567	protein ubiquitination
0.54	GO:0071425	hematopoietic stem cell proliferation
0.53	GO:1903955	positive regulation of protein targeting to mitochondrion
0.52	GO:0048588	developmental cell growth
0.51	GO:0006511	ubiquitin-dependent protein catabolic process
0.48	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.33	GO:0055114	oxidation-reduction process

0.73	GO:0004842	ubiquitin-protein transferase activity
0.56	GO:0031624	ubiquitin conjugating enzyme binding
0.54	GO:0046872	metal ion binding
0.51	GO:0016874	ligase activity
0.45	GO:0061659	ubiquitin-like protein ligase activity
0.35	GO:0031418	L-ascorbic acid binding
0.34	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.32	GO:0003676	nucleic acid binding

0.54	GO:0031466	Cul5-RING ubiquitin ligase complex
0.47	GO:0005654	nucleoplasm
0.39	GO:0005737	cytoplasm

0.51	EC:6	GO:0016874
0.73	KEGG:R03876	GO:0004842

sp|O95377|CXB5_HUMAN
Gap junction beta-5 protein
Search

GJB5

0.64	Gap junction protein beta 5

0.60	GO:0007154	cell communication
0.58	GO:0060708	spongiotrophoblast differentiation
0.57	GO:0060707	trophoblast giant cell differentiation
0.56	GO:0060713	labyrinthine layer morphogenesis
0.50	GO:0042048	olfactory behavior
0.46	GO:0007608	sensory perception of smell
0.41	GO:1905867	epididymis development
0.35	GO:0008544	epidermis development

0.83	GO:0005922	connexin complex
0.45	GO:0005730	nucleolus
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O95379|TFIP8_HUMAN
Tumor necrosis factor alpha-induced protein 8
Search

TNFAIP8

0.93	TNF alpha induced protein 8

0.74	GO:0042981	regulation of apoptotic process
0.71	GO:2000117	negative regulation of cysteine-type endopeptidase activity
0.66	GO:0043069	negative regulation of programmed cell death
0.65	GO:0006915	apoptotic process
0.65	GO:0043068	positive regulation of programmed cell death
0.43	GO:0032611	interleukin-1 beta production
0.42	GO:0050830	defense response to Gram-positive bacterium
0.41	GO:0032007	negative regulation of TOR signaling

0.73

GO:0043027

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

0.58	GO:0005654	nucleoplasm
0.44	GO:0005737	cytoplasm

sp|O95382|M3K6_HUMAN
Mitogen-activated protein kinase kinase kinase 6
Search

MAP3K6

0.85	Mitogen-activated protein kinase kinase kinase 6

0.63	GO:0000186	activation of MAPKK activity
0.63	GO:0006468	protein phosphorylation
0.50	GO:0035556	intracellular signal transduction
0.49	GO:1902170	cellular response to reactive nitrogen species
0.49	GO:0036473	cell death in response to oxidative stress
0.49	GO:0043507	positive regulation of JUN kinase activity
0.49	GO:0045663	positive regulation of myoblast differentiation
0.48	GO:0000187	activation of MAPK activity
0.48	GO:0097300	programmed necrotic cell death
0.48	GO:1901216	positive regulation of neuron death

0.64	GO:0004709	MAP kinase kinase kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0000287	magnesium ion binding
0.47	GO:0019903	protein phosphatase binding
0.46	GO:0019901	protein kinase binding
0.45	GO:0019904	protein domain specific binding
0.45	GO:0042803	protein homodimerization activity

0.50	GO:1990604	IRE1-TRAF2-ASK1 complex
0.46	GO:1902911	protein kinase complex
0.37	GO:0009897	external side of plasma membrane
0.35	GO:0005829	cytosol
0.33	GO:0015630	microtubule cytoskeleton

0.64

EC:2.7.11 EC:2.7.11.25

GO:0004709

sp|O95388|WISP1_HUMAN
WNT1-inducible-signaling pathway protein 1
Search

WISP1

0.97	WNT1 inducible signaling pathway protein 1

0.77	GO:0001558	regulation of cell growth
0.46	GO:0060548	negative regulation of cell death
0.45	GO:0007267	cell-cell signaling
0.44	GO:0007155	cell adhesion
0.40	GO:0007165	signal transduction
0.36	GO:0014742	positive regulation of muscle hypertrophy
0.36	GO:2000727	positive regulation of cardiac muscle cell differentiation
0.36	GO:0055023	positive regulation of cardiac muscle tissue growth
0.36	GO:0010611	regulation of cardiac muscle hypertrophy
0.35	GO:0048661	positive regulation of smooth muscle cell proliferation

0.82	GO:0005520	insulin-like growth factor binding
0.48	GO:0005178	integrin binding
0.47	GO:0008201	heparin binding

0.66	GO:0005576	extracellular region
0.48	GO:0005829	cytosol
0.33	GO:0005783	endoplasmic reticulum

sp|O95389|WISP3_HUMAN
WNT1-inducible-signaling pathway protein 3
Search

WISP3

0.97	WNT1 inducible signaling pathway protein 3 variant

0.74	GO:0001558	regulation of cell growth
0.45	GO:0060548	negative regulation of cell death
0.43	GO:0007267	cell-cell signaling
0.43	GO:0007155	cell adhesion
0.42	GO:0030514	negative regulation of BMP signaling pathway
0.41	GO:0030509	BMP signaling pathway
0.41	GO:0051216	cartilage development
0.41	GO:0009953	dorsal/ventral pattern formation
0.41	GO:0030178	negative regulation of Wnt signaling pathway
0.36	GO:0010469	regulation of receptor activity

0.78	GO:0005520	insulin-like growth factor binding
0.47	GO:0005178	integrin binding
0.46	GO:0008201	heparin binding
0.36	GO:0008083	growth factor activity

0.63	GO:0005576	extracellular region
0.48	GO:0005783	endoplasmic reticulum

sp|O95390|GDF11_HUMAN
Growth/differentiation factor 11
Search

GDF11

0.94	Growth differentiation factor 11

0.75	GO:0010469	regulation of receptor activity
0.58	GO:0021512	spinal cord anterior/posterior patterning
0.57	GO:0060395	SMAD protein signal transduction
0.56	GO:0045596	negative regulation of cell differentiation
0.56	GO:0008285	negative regulation of cell proliferation
0.53	GO:0001656	metanephros development
0.53	GO:0001657	ureteric bud development
0.53	GO:0060021	palate development
0.53	GO:0031016	pancreas development
0.53	GO:0048593	camera-type eye morphogenesis

0.78	GO:0008083	growth factor activity
0.49	GO:0005160	transforming growth factor beta receptor binding
0.48	GO:0005125	cytokine activity
0.40	GO:0008201	heparin binding
0.39	GO:0042802	identical protein binding
0.37	GO:0046983	protein dimerization activity

0.66	GO:0005576	extracellular region
0.47	GO:0005654	nucleoplasm
0.43	GO:0043234	protein complex
0.32	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O95391|SLU7_HUMAN
Pre-mRNA-splicing factor SLU7
Search

SLU7

0.86	Pre-mRNA-splicing factor SLU7

0.84	GO:0000389	mRNA 3'-splice site recognition
0.82	GO:0000380	alternative mRNA splicing, via spliceosome
0.77	GO:0034605	cellular response to heat
0.66	GO:0006886	intracellular protein transport
0.40	GO:0006369	termination of RNA polymerase II transcription
0.39	GO:0031124	mRNA 3'-end processing
0.39	GO:0071166	ribonucleoprotein complex localization
0.39	GO:0051169	nuclear transport
0.38	GO:0051028	mRNA transport
0.38	GO:0006405	RNA export from nucleus

0.85	GO:0000386	second spliceosomal transesterification activity
0.84	GO:0030628	pre-mRNA 3'-splice site binding
0.60	GO:0008270	zinc ion binding
0.36	GO:0005515	protein binding

0.77	GO:0071013	catalytic step 2 spliceosome
0.75	GO:0016607	nuclear speck
0.73	GO:0030532	small nuclear ribonucleoprotein complex
0.65	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O95393|BMP10_HUMAN
Bone morphogenetic protein 10
Search

BMP10

0.95	Growth differentiation factor 2

0.76	GO:0010469	regulation of receptor activity
0.67	GO:0060389	pathway-restricted SMAD protein phosphorylation
0.66	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.66	GO:0032924	activin receptor signaling pathway
0.65	GO:0010596	negative regulation of endothelial cell migration
0.65	GO:0061036	positive regulation of cartilage development
0.65	GO:0030509	BMP signaling pathway
0.65	GO:0060298	positive regulation of sarcomere organization
0.64	GO:1903242	regulation of cardiac muscle hypertrophy in response to stress
0.63	GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis

0.78	GO:0008083	growth factor activity
0.65	GO:0031433	telethonin binding
0.63	GO:0033612	receptor serine/threonine kinase binding
0.57	GO:0005179	hormone activity
0.51	GO:0005160	transforming growth factor beta receptor binding
0.49	GO:0005125	cytokine activity
0.34	GO:0005501	retinoid binding
0.33	GO:0008236	serine-type peptidase activity

0.66	GO:0005576	extracellular region
0.60	GO:0030018	Z disc
0.55	GO:0009986	cell surface
0.33	GO:0031982	vesicle
0.30	GO:0016020	membrane

sp|O95394|AGM1_HUMAN
Phosphoacetylglucosamine mutase
Search

PGM3

0.74	Phosphoacetylglucosamine mutase

0.72	GO:0006048	UDP-N-acetylglucosamine biosynthetic process
0.59	GO:0019255	glucose 1-phosphate metabolic process
0.58	GO:0005975	carbohydrate metabolic process
0.54	GO:0030097	hemopoiesis
0.53	GO:0006487	protein N-linked glycosylation
0.53	GO:0007283	spermatogenesis
0.53	GO:0006493	protein O-linked glycosylation
0.36	GO:0006041	glucosamine metabolic process

0.84	GO:0004610	phosphoacetylglucosamine mutase activity
0.62	GO:0000287	magnesium ion binding
0.53	GO:0004614	phosphoglucomutase activity

0.42

GO:0005829

cytosol

0.84	EC:5.4.2.3	GO:0004610
0.84	KEGG:R08193	GO:0004610

sp|O95395|GCNT3_HUMAN
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
Search

GCNT3

0.95	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

0.60	GO:0060993	kidney morphogenesis
0.60	GO:0002426	immunoglobulin production in mucosal tissue
0.57	GO:0048729	tissue morphogenesis
0.57	GO:0050892	intestinal absorption
0.51	GO:0060352	cell adhesion molecule production
0.50	GO:0009101	glycoprotein biosynthetic process
0.49	GO:0050901	leukocyte tethering or rolling
0.44	GO:0043413	macromolecule glycosylation
0.40	GO:0036211	protein modification process
0.38	GO:0044267	cellular protein metabolic process

0.77	GO:0008375	acetylglucosaminyltransferase activity
0.58	GO:0140103	catalytic activity, acting on a glycoprotein
0.33	GO:0005515	protein binding

0.48	GO:0098791	Golgi subcompartment
0.41	GO:0098588	bounding membrane of organelle
0.38	GO:0044178	host cell Golgi membrane
0.37	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.77

GO:0008375

sp|O95396|MOCS3_HUMAN
Adenylyltransferase and sulfurtransferase MOCS3
Search

MOCS3

0.86	Adenylyltransferase and sulfurtransferase MOCS3

0.77	GO:0098822	peptidyl-cysteine modification to L-cysteine persulfide
0.74	GO:0002143	tRNA wobble position uridine thiolation
0.73	GO:0018307	enzyme active site formation
0.65	GO:0006777	Mo-molybdopterin cofactor biosynthetic process
0.50	GO:0032447	protein urmylation
0.35	GO:0032324	molybdopterin cofactor biosynthetic process

0.77	GO:0061604	molybdopterin-synthase sulfurtransferase activity
0.76	GO:0061605	molybdopterin-synthase adenylyltransferase activity
0.73	GO:0008641	ubiquitin-like modifier activating enzyme activity
0.71	GO:0004792	thiosulfate sulfurtransferase activity
0.51	GO:0032559	adenyl ribonucleotide binding
0.50	GO:0008144	drug binding
0.50	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.62	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.77	EC:2.8.1.11	GO:0061604
0.71	KEGG:R01931	GO:0004792

sp|O95397|PKHA9_HUMAN
Putative protein PLEKHA9
Search

PLEKHA8

0.95	Pleckstrin like proteiny domain-containing family A member 8

0.84	GO:0120009	intermembrane lipid transfer
0.62	GO:0035621	ER to Golgi ceramide transport
0.62	GO:0046836	glycolipid transport
0.37	GO:0015031	protein transport
0.35	GO:0006661	phosphatidylinositol biosynthetic process

0.84	GO:0120013	intermembrane lipid transfer activity
0.64	GO:0017089	glycolipid transporter activity
0.61	GO:0097001	ceramide binding
0.60	GO:0051861	glycolipid binding
0.57	GO:0070273	phosphatidylinositol-4-phosphate binding
0.35	GO:0042802	identical protein binding
0.33	GO:0003779	actin binding

0.55	GO:0005802	trans-Golgi network
0.51	GO:0005654	nucleoplasm
0.35	GO:0000139	Golgi membrane

sp|O95398|RPGF3_HUMAN
Rap guanine nucleotide exchange factor 3
Search

RAPGEF3

0.97	Exchange protein directly activated by cAMP 1

0.75	GO:0007264	small GTPase mediated signal transduction
0.66	GO:0065009	regulation of molecular function
0.60	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion
0.58	GO:0060143	positive regulation of syncytium formation by plasma membrane fusion
0.57	GO:0061028	establishment of endothelial barrier
0.57	GO:0071320	cellular response to cAMP
0.57	GO:0051496	positive regulation of stress fiber assembly
0.57	GO:2000249	regulation of actin cytoskeleton reorganization
0.57	GO:0046827	positive regulation of protein export from nucleus
0.56	GO:1901985	positive regulation of protein acetylation

0.75	GO:0005085	guanyl-nucleotide exchange factor activity
0.52	GO:0019904	protein domain specific binding
0.51	GO:0017016	Ras GTPase binding
0.40	GO:0030552	cAMP binding
0.36	GO:0044325	ion channel binding

0.56	GO:0005902	microvillus
0.56	GO:0030175	filopodium
0.55	GO:0030027	lamellipodium
0.54	GO:0030864	cortical actin cytoskeleton
0.42	GO:0005886	plasma membrane
0.37	GO:0070062	extracellular exosome
0.37	GO:1990795	rod bipolar cell terminal bouton
0.37	GO:1990794	basolateral part of cell
0.37	GO:1990796	photoreceptor cell terminal bouton
0.36	GO:0097470	ribbon synapse

sp|O95399|UTS2_HUMAN
Urotensin-2
Search

UTS2

0.92	Urotensin II

0.83	GO:0008217	regulation of blood pressure
0.83	GO:0097746	regulation of blood vessel diameter
0.76	GO:0010469	regulation of receptor activity
0.48	GO:0046005	positive regulation of circadian sleep/wake cycle, REM sleep
0.47	GO:0035814	negative regulation of renal sodium excretion
0.47	GO:0035811	negative regulation of urine volume
0.47	GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness
0.46	GO:0032224	positive regulation of synaptic transmission, cholinergic
0.46	GO:0010459	negative regulation of heart rate
0.46	GO:0010763	positive regulation of fibroblast migration

0.79

GO:0005179

hormone activity

0.66	GO:0005576	extracellular region
0.30	GO:0005623	cell

sp|O95400|CD2B2_HUMAN
CD2 antigen cytoplasmic tail-binding protein 2
Search

CD2BP2

0.93	Neutral sphingomyelinase N-smase activation associated factor (Fragment)

0.78	GO:0010923	negative regulation of phosphatase activity
0.41	GO:0008380	RNA splicing
0.40	GO:0006397	mRNA processing
0.38	GO:0022618	ribonucleoprotein complex assembly
0.35	GO:0055085	transmembrane transport

0.70	GO:0043021	ribonucleoprotein complex binding
0.36	GO:0005515	protein binding
0.33	GO:0003677	DNA binding

0.82	GO:0005682	U5 snRNP
0.80	GO:0001650	fibrillar center
0.77	GO:0016607	nuclear speck
0.66	GO:0005829	cytosol
0.43	GO:0046540	U4/U6 x U5 tri-snRNP complex
0.30	GO:0031224	intrinsic component of membrane

sp|O95402|MED26_HUMAN
Mediator of RNA polymerase II transcription subunit 26
Search

MED26

0.87	LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 26

0.40	GO:0006357	regulation of transcription by RNA polymerase II
0.36	GO:0006351	transcription, DNA-templated

0.43	GO:0001104	RNA polymerase II transcription cofactor activity
0.36	GO:0003713	transcription coactivator activity
0.34	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.50	GO:0031974	membrane-enclosed lumen
0.46	GO:0043234	protein complex
0.45	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|O95405|ZFYV9_HUMAN
Zinc finger FYVE domain-containing protein 9
Search

ZFYVE9

0.95	Smad anchor for receptor activation

0.60	GO:0007184	SMAD protein import into nucleus
0.59	GO:0007183	SMAD protein complex assembly
0.56	GO:0007179	transforming growth factor beta receptor signaling pathway
0.38	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
0.36	GO:0001889	liver development
0.35	GO:0007399	nervous system development
0.35	GO:0006897	endocytosis
0.34	GO:0050673	epithelial cell proliferation
0.34	GO:0022612	gland morphogenesis
0.34	GO:0006508	proteolysis

0.56	GO:0005545	1-phosphatidylinositol binding
0.53	GO:0046872	metal ion binding
0.52	GO:0019904	protein domain specific binding
0.38	GO:0046332	SMAD binding
0.34	GO:0017171	serine hydrolase activity
0.34	GO:0070011	peptidase activity, acting on L-amino acid peptides

0.57	GO:0031901	early endosome membrane
0.49	GO:0005829	cytosol
0.44	GO:0043234	protein complex
0.42	GO:0043231	intracellular membrane-bounded organelle

sp|O95406|CNIH1_HUMAN
Protein cornichon homolog 1
Search

CNIH1

0.92	Putative er vesicle integral membrane protein involved in establishing cell polarity signaling

0.69	GO:0016192	vesicle-mediated transport
0.41	GO:0007310	oocyte dorsal/ventral axis specification
0.41	GO:0046843	dorsal appendage formation
0.40	GO:0007350	blastoderm segmentation
0.39	GO:0009952	anterior/posterior pattern specification
0.38	GO:0046907	intracellular transport
0.35	GO:0008314	gurken signaling pathway
0.34	GO:0051650	establishment of vesicle localization
0.34	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation
0.34	GO:0016050	vesicle organization

0.35	GO:0003779	actin binding
0.34	GO:0071933	Arp2/3 complex binding

0.40	GO:0005789	endoplasmic reticulum membrane
0.37	GO:0000139	Golgi membrane
0.35	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
0.34	GO:0012507	ER to Golgi transport vesicle membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O95407|TNF6B_HUMAN
Tumor necrosis factor receptor superfamily member 6B
Search

TNFRSF6B

0.97	LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 6B

0.71	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.67	GO:0006954	inflammatory response
0.66	GO:0032496	response to lipopolysaccharide
0.65	GO:0097190	apoptotic signaling pathway
0.63	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.62	GO:0042127	regulation of cell proliferation
0.60	GO:0006955	immune response
0.57	GO:0007275	multicellular organism development
0.37	GO:0043043	peptide biosynthetic process
0.36	GO:0044267	cellular protein metabolic process

0.74	GO:0005031	tumor necrosis factor-activated receptor activity
0.41	GO:0005515	protein binding
0.38	GO:0003735	structural constituent of ribosome

0.55	GO:0005887	integral component of plasma membrane
0.46	GO:0005615	extracellular space
0.43	GO:0005634	nucleus
0.38	GO:1903561	extracellular vesicle
0.37	GO:0005840	ribosome

sp|O95409|ZIC2_HUMAN
Zinc finger protein ZIC 2
Search

ZIC2

0.93	Zinc finger protein ZIC 2-B

0.49	GO:0007417	central nervous system development
0.47	GO:0048513	animal organ development
0.47	GO:0048598	embryonic morphogenesis
0.46	GO:0060322	head development
0.46	GO:0043009	chordate embryonic development
0.45	GO:0030154	cell differentiation
0.45	GO:0007389	pattern specification process
0.45	GO:0045893	positive regulation of transcription, DNA-templated
0.45	GO:0008589	regulation of smoothened signaling pathway
0.45	GO:0051091	positive regulation of DNA binding transcription factor activity

0.51	GO:0003676	nucleic acid binding
0.44	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.43	GO:0003682	chromatin binding
0.37	GO:0046872	metal ion binding
0.35	GO:0005515	protein binding

0.61	GO:0016604	nuclear body
0.37	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|O95411|TIAF1_HUMAN
TGFB1-induced anti-apoptotic factor 1
Search

0.85	GO:0007249	I-kappaB kinase/NF-kappaB signaling
0.78	GO:0043066	negative regulation of apoptotic process
0.78	GO:0006915	apoptotic process

0.61

GO:0005634

nucleus

sp|O95415|BRI3_HUMAN
Brain protein I3
Search

BRI3

0.97	Brain protein I3 isoform b

0.38

GO:0043312

neutrophil degranulation

0.52

GO:0042802

identical protein binding

0.44	GO:0005765	lysosomal membrane
0.38	GO:0042582	azurophil granule
0.37	GO:0030667	secretory granule membrane
0.34	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

sp|O95416|SOX14_HUMAN
Transcription factor SOX-14
Search

SOX14

0.94	Transcription factor SOX-14

0.55	GO:2001141	regulation of RNA biosynthetic process
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.53	GO:0009649	entrainment of circadian clock
0.52	GO:2001222	regulation of neuron migration
0.49	GO:0007601	visual perception
0.45	GO:0021854	hypothalamus development
0.38	GO:0051253	negative regulation of RNA metabolic process
0.38	GO:0010558	negative regulation of macromolecule biosynthetic process
0.38	GO:0031327	negative regulation of cellular biosynthetic process

0.54	GO:0003677	DNA binding
0.48	GO:0003682	chromatin binding
0.47	GO:0046982	protein heterodimerization activity
0.47	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.33	GO:0032440	2-alkenal reductase [NAD(P)] activity
0.32	GO:0005509	calcium ion binding
0.32	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005634	nucleus
0.48	GO:0005667	transcription factor complex
0.41	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.33

EC:1.3.1.74

GO:0032440

sp|O95424|DEXI_HUMAN
Dexamethasone-induced protein
Search

DEXI

0.97	Dexamethasone-induced transcript

0.30

GO:0044425

membrane part

sp|O95425|SVIL_HUMAN
Supervillin
Search

SVIL

0.94	Smooth muscle archvillin

0.71	GO:0007010	cytoskeleton organization
0.53	GO:0007519	skeletal muscle tissue development
0.39	GO:0032467	positive regulation of cytokinesis

0.78

GO:0051015

actin filament binding

0.56	GO:0043034	costamere
0.49	GO:0015629	actin cytoskeleton
0.47	GO:0005829	cytosol
0.44	GO:0005634	nucleus
0.41	GO:0005886	plasma membrane
0.40	GO:0036449	microtubule minus-end
0.40	GO:0071437	invadopodium
0.40	GO:0032154	cleavage furrow
0.39	GO:0030496	midbody
0.39	GO:0030054	cell junction

sp|O95427|PIGN_HUMAN
GPI ethanolamine phosphate transferase 1
Search

PIGN

0.94	Phosphatidylinositol glycan anchor biosynthesis class N

0.78

GO:0006506

GPI anchor biosynthetic process

0.84	GO:0051377	mannose-ethanolamine phosphotransferase activity
0.36	GO:0008484	sulfuric ester hydrolase activity

0.72	GO:0005789	endoplasmic reticulum membrane
0.57	GO:0005829	cytosol
0.48	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.36

EC:3.1.6

GO:0008484

sp|O95428|PPN_HUMAN
Papilin
Search

PAPLN

0.73	Papilin, proteoglycan like sulfated glycoprotein

0.74	GO:0010951	negative regulation of endopeptidase activity
0.58	GO:0006508	proteolysis
0.43	GO:0001658	branching involved in ureteric bud morphogenesis
0.36	GO:0007229	integrin-mediated signaling pathway
0.34	GO:1902017	regulation of cilium assembly
0.34	GO:0003073	regulation of systemic arterial blood pressure
0.34	GO:0006030	chitin metabolic process
0.34	GO:0048232	male gamete generation

0.76	GO:0004867	serine-type endopeptidase inhibitor activity
0.59	GO:0008233	peptidase activity
0.37	GO:0046872	metal ion binding
0.34	GO:0008061	chitin binding

0.52

GO:0005576

extracellular region

0.59

GO:0008233

sp|O95429|BAG4_HUMAN
BAG family molecular chaperone regulator 4
Search

BAG4

0.95	BCL2-associated athanogene 4

0.82	GO:2001145	negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
0.82	GO:1903215	negative regulation of protein targeting to mitochondrion
0.78	GO:0010763	positive regulation of fibroblast migration
0.76	GO:0097178	ruffle assembly
0.76	GO:0071364	cellular response to epidermal growth factor stimulus
0.75	GO:0051496	positive regulation of stress fiber assembly
0.74	GO:0071356	cellular response to tumor necrosis factor
0.74	GO:0051897	positive regulation of protein kinase B signaling
0.74	GO:0033138	positive regulation of peptidyl-serine phosphorylation
0.72	GO:0072659	protein localization to plasma membrane

0.77	GO:0051087	chaperone binding
0.70	GO:0031625	ubiquitin protein ligase binding
0.37	GO:0003723	RNA binding

0.61	GO:0005829	cytosol
0.56	GO:0005634	nucleus
0.51	GO:0005886	plasma membrane
0.35	GO:0030018	Z disc

sp|O95433|AHSA1_HUMAN
Activator of 90 kDa heat shock protein ATPase homolog 1
Search

AHSA1

0.94	Activator heat shock protein ATPase 1

0.78	GO:0032781	positive regulation of ATPase activity
0.59	GO:0006950	response to stress
0.37	GO:0048702	embryonic neurocranium morphogenesis
0.34	GO:0006457	protein folding

0.78	GO:0001671	ATPase activator activity
0.74	GO:0051087	chaperone binding
0.56	GO:0045296	cadherin binding

0.49	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.36	GO:0005783	endoplasmic reticulum

sp|O95436|NPT2B_HUMAN
Sodium-dependent phosphate transport protein 2B
Search

SLC34A2

0.95	Type IIb Na-dependent phosphate cotransporter

0.81	GO:0044341	sodium-dependent phosphate transport
0.56	GO:0072506	trivalent inorganic anion homeostasis
0.56	GO:0072505	divalent inorganic anion homeostasis
0.56	GO:0055083	monovalent inorganic anion homeostasis
0.56	GO:0035725	sodium ion transmembrane transport
0.56	GO:0035435	phosphate ion transmembrane transport
0.55	GO:0043627	response to estrogen
0.55	GO:0030002	cellular anion homeostasis
0.51	GO:0001701	in utero embryonic development
0.44	GO:0010288	response to lead ion

0.81	GO:0015321	sodium-dependent phosphate transmembrane transporter activity
0.63	GO:0005436	sodium:phosphate symporter activity
0.53	GO:0031402	sodium ion binding
0.52	GO:0042301	phosphate ion binding
0.38	GO:0015370	solute:sodium symporter activity
0.36	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.36	GO:0019904	protein domain specific binding
0.34	GO:0042803	protein homodimerization activity
0.34	GO:0032403	protein complex binding
0.33	GO:0005057	signal transducer activity, downstream of receptor

0.60	GO:0016324	apical plasma membrane
0.57	GO:0005903	brush border
0.45	GO:0031982	vesicle
0.42	GO:0072686	mitotic spindle
0.42	GO:0016607	nuclear speck
0.42	GO:0045203	integral component of cell outer membrane
0.38	GO:0031253	cell projection membrane
0.37	GO:0005737	cytoplasm
0.35	GO:0005902	microvillus
0.35	GO:0031226	intrinsic component of plasma membrane

0.36

EC:2.7.10.1

GO:0004714

sp|O95445|APOM_HUMAN
Apolipoprotein M
Search

APOM

0.97	Apolipoprotein M

0.87	GO:0034444	regulation of plasma lipoprotein oxidation
0.87	GO:0034384	high-density lipoprotein particle clearance
0.86	GO:0034380	high-density lipoprotein particle assembly
0.86	GO:0034375	high-density lipoprotein particle remodeling
0.86	GO:0043691	reverse cholesterol transport
0.85	GO:0033344	cholesterol efflux
0.77	GO:0051241	negative regulation of multicellular organismal process
0.76	GO:0051129	negative regulation of cellular component organization
0.74	GO:0042157	lipoprotein metabolic process
0.68	GO:0098869	cellular oxidant detoxification

0.76	GO:0005319	lipid transporter activity
0.74	GO:0005543	phospholipid binding
0.69	GO:0016209	antioxidant activity
0.37	GO:0005515	protein binding

0.88	GO:0034365	discoidal high-density lipoprotein particle
0.86	GO:0034366	spherical high-density lipoprotein particle
0.86	GO:0034362	low-density lipoprotein particle
0.85	GO:0034361	very-low-density lipoprotein particle
0.45	GO:0070062	extracellular exosome
0.38	GO:0005887	integral component of plasma membrane

sp|O95447|LCA5L_HUMAN
Lebercilin-like protein
Search

LCA5L

0.97	Leber congenital amaurosis 5-like

0.39	GO:0006412	translation
0.37	GO:0015031	protein transport

0.62	GO:0044877	macromolecular complex binding
0.60	GO:0031490	chromatin DNA binding
0.54	GO:0005515	protein binding
0.40	GO:0003735	structural constituent of ribosome

0.56	GO:0005929	cilium
0.54	GO:0000785	chromatin
0.48	GO:0005634	nucleus
0.40	GO:0005840	ribosome
0.38	GO:0005815	microtubule organizing center

sp|O95450|ATS2_HUMAN
A disintegrin and metalloproteinase with thrombospondin motifs 2
Search

ADAMTS2

0.95	A disintegrin and metalloproteinase with thrombospondin motifs 2

0.66	GO:0007229	integrin-mediated signaling pathway
0.60	GO:0006508	proteolysis
0.57	GO:0030199	collagen fibril organization
0.56	GO:0030324	lung development
0.55	GO:0043588	skin development
0.54	GO:0007283	spermatogenesis
0.50	GO:0051604	protein maturation
0.40	GO:0032963	collagen metabolic process
0.40	GO:0044243	multicellular organismal catabolic process
0.36	GO:0009056	catabolic process

0.69	GO:0004222	metalloendopeptidase activity
0.57	GO:0008270	zinc ion binding

0.68	GO:0005578	proteinaceous extracellular matrix
0.51	GO:0005615	extracellular space

0.69

GO:0004222

sp|O95452|CXB6_HUMAN
Gap junction beta-6 protein
Search

GJB6

0.64	Gap junction beta-6 protein (Fragment)

0.60	GO:0007154	cell communication
0.56	GO:0043583	ear development
0.56	GO:0007605	sensory perception of sound
0.55	GO:0016264	gap junction assembly
0.53	GO:0048562	embryonic organ morphogenesis
0.53	GO:0090596	sensory organ morphogenesis
0.43	GO:0032496	response to lipopolysaccharide
0.43	GO:0007568	aging
0.42	GO:0023052	signaling
0.42	GO:0051602	response to electrical stimulus

0.55	GO:0005243	gap junction channel activity
0.48	GO:0042802	identical protein binding

0.83	GO:0005922	connexin complex
0.40	GO:0016324	apical plasma membrane
0.40	GO:0005829	cytosol
0.40	GO:0097449	astrocyte projection
0.39	GO:0016328	lateral plasma membrane
0.38	GO:0044297	cell body
0.38	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.30	GO:0016021	integral component of membrane

sp|O95453|PARN_HUMAN
Poly(A)-specific ribonuclease PARN
Search

PARN

0.90	Poly(A)-specific ribonuclease (Deadenylation nuclease)

0.74	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
0.73	GO:0006402	mRNA catabolic process
0.62	GO:0110008	ncRNA deadenylation
0.60	GO:0090669	telomerase RNA stabilization
0.59	GO:1904872	regulation of telomerase RNA localization to Cajal body
0.58	GO:0051973	positive regulation of telomerase activity
0.57	GO:0032212	positive regulation of telomere maintenance via telomerase
0.35	GO:0022414	reproductive process
0.35	GO:0043488	regulation of mRNA stability
0.35	GO:0032501	multicellular organismal process

0.83	GO:0004535	poly(A)-specific ribonuclease activity
0.58	GO:0003723	RNA binding
0.53	GO:0019901	protein kinase binding
0.53	GO:0046872	metal ion binding

0.60	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.34	GO:0044446	intracellular organelle part

0.83

EC:3.1.13.4

GO:0004535

sp|O95455|TGDS_HUMAN
dTDP-D-glucose 4,6-dehydratase
Search

TGDS

0.87	dTDP-D-glucose 4,6-dehydratase

0.39	GO:0009225	nucleotide-sugar metabolic process
0.38	GO:0045454	cell redox homeostasis
0.35	GO:0055114	oxidation-reduction process

0.65	GO:0008460	dTDP-glucose 4,6-dehydratase activity
0.42	GO:0050662	coenzyme binding
0.39	GO:0046982	protein heterodimerization activity
0.35	GO:0003677	DNA binding
0.35	GO:0016491	oxidoreductase activity

0.39	GO:0000786	nucleosome
0.37	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.65	EC:4.2.1.46	GO:0008460
0.65	KEGG:R06513	GO:0008460

sp|O95456|PSMG1_HUMAN
Proteasome assembly chaperone 1
Search

PSMG1

0.96	Proteasome assembly chaperone 1

0.81	GO:0043248	proteasome assembly
0.64	GO:0021924	cell proliferation in external granule layer
0.34	GO:0006413	translational initiation

0.61	GO:0070628	proteasome binding
0.35	GO:0003743	translation initiation factor activity

0.70	GO:0005783	endoplasmic reticulum
0.62	GO:1905369	endopeptidase complex
0.54	GO:0005794	Golgi apparatus
0.53	GO:0005654	nucleoplasm
0.52	GO:0005829	cytosol
0.52	GO:0043234	protein complex
0.30	GO:0016020	membrane

sp|O95460|MATN4_HUMAN
Matrilin-4
Search

MATN4

0.95	Matrilin-4

0.36	GO:0030198	extracellular matrix organization
0.33	GO:0010466	negative regulation of peptidase activity

0.69	GO:0005509	calcium ion binding
0.34	GO:0005515	protein binding
0.33	GO:0030414	peptidase inhibitor activity
0.33	GO:0000287	magnesium ion binding

0.35	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

sp|O95461|LARG1_HUMAN
LARGE xylosyl- and glucuronyltransferase 1
Search

LARGE1

0.96	LARGE xylosyl- and glucuronyltransferase 1

0.57	GO:0035269	protein O-linked mannosylation
0.50	GO:0043403	skeletal muscle tissue regeneration
0.49	GO:0046716	muscle cell cellular homeostasis
0.48	GO:0060538	skeletal muscle organ development
0.35	GO:0006688	glycosphingolipid biosynthetic process
0.34	GO:0006044	N-acetylglucosamine metabolic process

0.64	GO:0016757	transferase activity, transferring glycosyl groups
0.50	GO:0030145	manganese ion binding
0.34	GO:0005515	protein binding

0.50	GO:0005794	Golgi apparatus
0.37	GO:0098588	bounding membrane of organelle
0.37	GO:0031984	organelle subcompartment
0.34	GO:0031301	integral component of organelle membrane

0.64

EC:2.4

GO:0016757

sp|O95466|FMNL1_HUMAN
Formin-like protein 1
Search

FMNL1

0.90	Formin protein 1

0.72	GO:0030036	actin cytoskeleton organization
0.69	GO:0022604	regulation of cell morphogenesis
0.62	GO:0065008	regulation of biological quality
0.59	GO:0006929	substrate-dependent cell migration
0.56	GO:0051014	actin filament severing
0.56	GO:0030865	cortical cytoskeleton organization
0.39	GO:0032273	positive regulation of protein polymerization
0.39	GO:1902905	positive regulation of supramolecular fiber organization
0.39	GO:0051495	positive regulation of cytoskeleton organization
0.39	GO:0110053	regulation of actin filament organization

0.75	GO:0017048	Rho GTPase binding
0.72	GO:0003779	actin binding
0.60	GO:0032794	GTPase activating protein binding
0.60	GO:0005522	profilin binding
0.52	GO:0032403	protein complex binding
0.39	GO:0045296	cadherin binding
0.38	GO:0008017	microtubule binding
0.34	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
0.34	GO:0017069	snRNA binding
0.34	GO:0000062	fatty-acyl-CoA binding

0.56	GO:0045335	phagocytic vesicle
0.50	GO:0005829	cytosol
0.43	GO:0005886	plasma membrane
0.40	GO:0070062	extracellular exosome
0.40	GO:0005884	actin filament
0.38	GO:0032059	bleb
0.36	GO:0005938	cell cortex
0.35	GO:0005794	Golgi apparatus
0.33	GO:0005634	nucleus

sp|O95470|SGPL1_HUMAN
Sphingosine-1-phosphate lyase 1
Search

SGPL1

0.96	Sphingosine-1-phosphate lyase 1

0.56	GO:0019752	carboxylic acid metabolic process
0.56	GO:0001553	luteinization
0.56	GO:0033327	Leydig cell differentiation
0.56	GO:0010761	fibroblast migration
0.55	GO:0008209	androgen metabolic process
0.55	GO:0008210	estrogen metabolic process
0.54	GO:0060325	face morphogenesis
0.54	GO:0048008	platelet-derived growth factor receptor signaling pathway
0.54	GO:0030149	sphingolipid catabolic process
0.53	GO:0001570	vasculogenesis

0.66	GO:0016831	carboxy-lyase activity
0.65	GO:0030170	pyridoxal phosphate binding
0.57	GO:0008117	sphinganine-1-phosphate aldolase activity
0.33	GO:0005515	protein binding

0.48	GO:0005783	endoplasmic reticulum
0.37	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.37	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.66

EC:4.1.1

GO:0016831

sp|O95471|CLD7_HUMAN
Claudin-7
Search

0.68

Claudin

0.55	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
0.52	GO:0061436	establishment of skin barrier
0.51	GO:0070830	bicellular tight junction assembly
0.51	GO:0051291	protein heterooligomerization
0.48	GO:0051260	protein homooligomerization
0.44	GO:0051806	entry into cell of other organism involved in symbiotic interaction
0.44	GO:0044409	entry into host
0.43	GO:0019058	viral life cycle
0.42	GO:0045471	response to ethanol
0.41	GO:0061772	drug transport across blood-nerve barrier

0.62	GO:0005198	structural molecule activity
0.52	GO:0104005	hijacked molecular function
0.48	GO:0042802	identical protein binding
0.38	GO:0050839	cell adhesion molecule binding
0.32	GO:0046872	metal ion binding

0.81	GO:0005923	bicellular tight junction
0.62	GO:0016328	lateral plasma membrane
0.60	GO:0016323	basolateral plasma membrane
0.56	GO:0016327	apicolateral plasma membrane
0.49	GO:0016324	apical plasma membrane
0.44	GO:0005887	integral component of plasma membrane
0.33	GO:0005737	cytoplasm
0.32	GO:0005634	nucleus

sp|O95473|SNG4_HUMAN
Synaptogyrin-4
Search

0.89	Synaptogyrin

0.42	GO:0048172	regulation of short-term neuronal synaptic plasticity
0.41	GO:0048169	regulation of long-term neuronal synaptic plasticity
0.41	GO:1990830	cellular response to leukemia inhibitory factor
0.36	GO:0048499	synaptic vesicle membrane organization
0.35	GO:0045055	regulated exocytosis
0.35	GO:0006470	protein dephosphorylation
0.34	GO:0006605	protein targeting
0.34	GO:0060976	coronary vasculature development
0.34	GO:0035904	aorta development
0.34	GO:0000185	activation of MAPKKK activity

0.35	GO:0004722	protein serine/threonine phosphatase activity
0.34	GO:0019209	kinase activator activity
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0016301	kinase activity
0.32	GO:0003723	RNA binding

0.53	GO:0030672	synaptic vesicle membrane
0.53	GO:0031594	neuromuscular junction
0.36	GO:0043195	terminal bouton
0.35	GO:0042470	melanosome
0.34	GO:0030054	cell junction
0.33	GO:0016607	nuclear speck
0.33	GO:0005829	cytosol
0.32	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

sp|O95475|SIX6_HUMAN
Homeobox protein SIX6
Search

SIX6

0.94	SIX homeobox 6

0.80	GO:0001654	eye development
0.70	GO:0006357	regulation of transcription by RNA polymerase II
0.61	GO:0006366	transcription by RNA polymerase II
0.60	GO:0007420	brain development
0.59	GO:0045893	positive regulation of transcription, DNA-templated
0.53	GO:0097402	neuroblast migration
0.53	GO:1990086	lens fiber cell apoptotic process
0.52	GO:0009946	proximal/distal axis specification
0.52	GO:0090596	sensory organ morphogenesis
0.52	GO:0061074	regulation of neural retina development

0.73	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.55	GO:0003677	DNA binding
0.52	GO:0001222	transcription corepressor binding
0.50	GO:0042826	histone deacetylase binding
0.48	GO:0003713	transcription coactivator activity
0.47	GO:0001067	regulatory region nucleic acid binding
0.37	GO:0005102	receptor binding

0.61

GO:0005634

nucleus

sp|O95476|CNEP1_HUMAN
CTD nuclear envelope phosphatase 1
Search

CTDNEP1

0.96	Serine/threonine-protein phosphatase dullard-A

0.66	GO:0016311	dephosphorylation
0.55	GO:0010867	positive regulation of triglyceride biosynthetic process
0.53	GO:0006998	nuclear envelope organization
0.49	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.49	GO:0007498	mesoderm development
0.49	GO:0034504	protein localization to nucleus
0.47	GO:0007276	gamete generation
0.43	GO:0036211	protein modification process
0.41	GO:0044267	cellular protein metabolic process
0.36	GO:0007399	nervous system development

0.67	GO:0016791	phosphatase activity
0.42	GO:0140096	catalytic activity, acting on a protein
0.35	GO:0005515	protein binding

0.55	GO:0071595	Nem1-Spo7 phosphatase complex
0.51	GO:0005811	lipid droplet
0.51	GO:0031965	nuclear membrane
0.48	GO:0005789	endoplasmic reticulum membrane
0.37	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.67

EC:3.1.3 EC:3.1.3.41

GO:0016791

sp|O95477|ABCA1_HUMAN
ATP-binding cassette sub-family A member 1
Search

ABCA1

0.91	ATP-binding cassette transporter 1

0.63	GO:0060155	platelet dense granule organization
0.63	GO:0038027	apolipoprotein A-I-mediated signaling pathway
0.62	GO:0010874	regulation of cholesterol efflux
0.62	GO:0050702	interleukin-1 beta secretion
0.62	GO:0032489	regulation of Cdc42 protein signal transduction
0.62	GO:0034380	high-density lipoprotein particle assembly
0.62	GO:0034616	response to laminar fluid shear stress
0.61	GO:0033700	phospholipid efflux
0.61	GO:0055091	phospholipid homeostasis
0.61	GO:0071404	cellular response to low-density lipoprotein particle stimulus

0.65	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.64	GO:0090556	phosphatidylserine-translocating ATPase activity
0.64	GO:0034188	apolipoprotein A-I receptor activity
0.63	GO:0090554	phosphatidylcholine-translocating ATPase activity
0.63	GO:0034186	apolipoprotein A-I binding
0.60	GO:0017127	cholesterol transporter activity
0.59	GO:0051117	ATPase binding
0.58	GO:0019905	syntaxin binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0031267	small GTPase binding

0.58	GO:0045335	phagocytic vesicle
0.56	GO:0098857	membrane microdomain
0.56	GO:0009897	external side of plasma membrane
0.55	GO:0048471	perinuclear region of cytoplasm
0.51	GO:0005794	Golgi apparatus
0.49	GO:0005887	integral component of plasma membrane
0.41	GO:0034364	high-density lipoprotein particle
0.35	GO:0016323	basolateral plasma membrane
0.35	GO:0016324	apical plasma membrane
0.34	GO:0005789	endoplasmic reticulum membrane

sp|O95478|NSA2_HUMAN
Ribosome biogenesis protein NSA2 homolog
Search

NSA2

0.81	TGF beta-inducible nuclear protein 1

0.79	GO:0000470	maturation of LSU-rRNA
0.78	GO:0000460	maturation of 5.8S rRNA

0.38	GO:0003723	RNA binding
0.34	GO:0046872	metal ion binding

0.78	GO:0030687	preribosome, large subunit precursor
0.71	GO:0005730	nucleolus
0.34	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

sp|O95479|G6PE_HUMAN
GDH/6PGL endoplasmic bifunctional protein
Search

H6PD

0.59	Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase

0.71	GO:0006098	pentose-phosphate shunt
0.71	GO:0006006	glucose metabolic process
0.52	GO:0055114	oxidation-reduction process
0.39	GO:0097305	response to alcohol
0.33	GO:0006044	N-acetylglucosamine metabolic process

0.79	GO:0017057	6-phosphogluconolactonase activity
0.78	GO:0004345	glucose-6-phosphate dehydrogenase activity
0.69	GO:0050661	NADP binding
0.39	GO:0047936	glucose 1-dehydrogenase [NAD(P)] activity
0.37	GO:0030246	carbohydrate binding
0.33	GO:0004342	glucosamine-6-phosphate deaminase activity

0.39	GO:0005788	endoplasmic reticulum lumen
0.35	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.79	EC:3.1.1.31	GO:0017057
0.79	KEGG:R02035	GO:0017057

sp|O95484|CLD9_HUMAN
Claudin-9
Search

0.70

Claudin

0.61	GO:0045216	cell-cell junction organization
0.52	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
0.51	GO:0070293	renal absorption
0.50	GO:0051806	entry into cell of other organism involved in symbiotic interaction
0.50	GO:0044409	entry into host
0.50	GO:0061436	establishment of skin barrier
0.49	GO:0019058	viral life cycle
0.46	GO:1902476	chloride transmembrane transport
0.46	GO:0003382	epithelial cell morphogenesis
0.46	GO:0051291	protein heterooligomerization

0.62	GO:0104005	hijacked molecular function
0.62	GO:0005198	structural molecule activity
0.47	GO:0005254	chloride channel activity
0.45	GO:0042802	identical protein binding
0.34	GO:0004888	transmembrane signaling receptor activity
0.31	GO:0016787	hydrolase activity

0.81	GO:0005923	bicellular tight junction
0.62	GO:0016327	apicolateral plasma membrane
0.47	GO:0016328	lateral plasma membrane
0.43	GO:0005887	integral component of plasma membrane
0.41	GO:0043227	membrane-bounded organelle
0.39	GO:0043229	intracellular organelle
0.37	GO:0034707	chloride channel complex
0.36	GO:0009925	basal plasma membrane
0.35	GO:0016324	apical plasma membrane
0.34	GO:0043230	extracellular organelle

0.31

GO:0016787

sp|O95486|SC24A_HUMAN
Protein transport protein Sec24A
Search

SEC24A

0.95	SEC24 homolog A, COPII coat complex component

0.78	GO:0006888	ER to Golgi vesicle-mediated transport
0.71	GO:0035459	cargo loading into vesicle
0.69	GO:0006886	intracellular protein transport
0.67	GO:0051668	localization within membrane
0.66	GO:0048194	Golgi vesicle budding
0.60	GO:2000189	positive regulation of cholesterol homeostasis
0.60	GO:0045714	regulation of low-density lipoprotein particle receptor biosynthetic process
0.55	GO:0050714	positive regulation of protein secretion
0.50	GO:1901301	regulation of cargo loading into COPII-coated vesicle
0.50	GO:0021747	cochlear nucleus development

0.63

GO:0008270

zinc ion binding

0.80	GO:0030127	COPII vesicle coat
0.60	GO:0000139	Golgi membrane
0.43	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O95487|SC24B_HUMAN
Protein transport protein Sec24B
Search

SEC24B

0.96	SEC24 homolog B, COPII coat complex component

0.78	GO:0006888	ER to Golgi vesicle-mediated transport
0.69	GO:0006886	intracellular protein transport
0.64	GO:1901301	regulation of cargo loading into COPII-coated vesicle
0.64	GO:0021747	cochlear nucleus development
0.63	GO:0035459	cargo loading into vesicle
0.63	GO:0060463	lung lobe morphogenesis
0.63	GO:0060982	coronary artery morphogenesis
0.63	GO:0061156	pulmonary artery morphogenesis
0.62	GO:0090178	regulation of establishment of planar polarity involved in neural tube closure
0.62	GO:0060088	auditory receptor cell stereocilium organization

0.63

GO:0008270

zinc ion binding

0.80	GO:0030127	COPII vesicle coat
0.55	GO:0000139	Golgi membrane
0.51	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O95490|AGRL2_HUMAN
Adhesion G protein-coupled receptor L2
Search

ADGRL2

0.88	Adhesion G protein-coupled receptor L2

0.71	GO:0007166	cell surface receptor signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.36	GO:0051965	positive regulation of synapse assembly
0.36	GO:0060317	cardiac epithelial to mesenchymal transition
0.34	GO:0007420	brain development

0.72	GO:0004930	G-protein coupled receptor activity
0.70	GO:0030246	carbohydrate binding
0.37	GO:0016524	latrotoxin receptor activity
0.35	GO:0030165	PDZ domain binding

0.34	GO:0043005	neuron projection
0.32	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

sp|O95497|VNN1_HUMAN
Pantetheinase
Search

VNN1

0.96	vascular non-inflammatory molecule 2

0.55	GO:0015939	pantothenate metabolic process
0.55	GO:0002544	chronic inflammatory response
0.55	GO:0033089	positive regulation of T cell differentiation in thymus
0.54	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
0.53	GO:0002526	acute inflammatory response
0.50	GO:0045087	innate immune response
0.49	GO:0098609	cell-cell adhesion
0.38	GO:0006501	C-terminal protein lipidation
0.36	GO:0043312	neutrophil degranulation
0.35	GO:0007186	G-protein coupled receptor signaling pathway

0.68	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
0.36	GO:0001594	trace-amine receptor activity
0.35	GO:0034235	GPI anchor binding

0.41	GO:0031225	anchored component of membrane
0.41	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.36	GO:0035577	azurophil granule membrane
0.36	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.68

EC:3.5.1

GO:0016811

sp|O95498|VNN2_HUMAN
Vascular non-inflammatory molecule 2
Search

0.95	Vascular non-inflammatory molecule 2

0.54	GO:0015939	pantothenate metabolic process
0.52	GO:0002544	chronic inflammatory response
0.52	GO:0033089	positive regulation of T cell differentiation in thymus
0.51	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
0.50	GO:0002526	acute inflammatory response
0.47	GO:0045087	innate immune response
0.47	GO:0098609	cell-cell adhesion
0.39	GO:0006501	C-terminal protein lipidation
0.35	GO:0043312	neutrophil degranulation
0.34	GO:0007186	G-protein coupled receptor signaling pathway

0.68	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
0.36	GO:0001594	trace-amine receptor activity
0.35	GO:0034235	GPI anchor binding

0.41	GO:0031225	anchored component of membrane
0.39	GO:0005615	extracellular space
0.36	GO:0005886	plasma membrane
0.36	GO:1903561	extracellular vesicle
0.35	GO:0035577	azurophil granule membrane
0.30	GO:0016021	integral component of membrane

0.68

EC:3.5.1

GO:0016811

sp|O95500|CLD14_HUMAN
Claudin-14
Search

CLDN14

0.65

Claudin

0.50	GO:0045216	cell-cell junction organization
0.48	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
0.46	GO:0070293	renal absorption
0.45	GO:0061436	establishment of skin barrier
0.43	GO:0003382	epithelial cell morphogenesis
0.43	GO:0051291	protein heterooligomerization
0.43	GO:1902476	chloride transmembrane transport
0.42	GO:0034329	cell junction assembly
0.42	GO:0001666	response to hypoxia
0.42	GO:0051806	entry into cell of other organism involved in symbiotic interaction

0.62	GO:0005198	structural molecule activity
0.48	GO:0104005	hijacked molecular function
0.43	GO:0005254	chloride channel activity
0.43	GO:0042802	identical protein binding
0.33	GO:0004888	transmembrane signaling receptor activity

0.81	GO:0005923	bicellular tight junction
0.55	GO:0005886	plasma membrane
0.37	GO:0043227	membrane-bounded organelle
0.37	GO:0045178	basal part of cell
0.37	GO:0045177	apical part of cell
0.36	GO:0043229	intracellular organelle
0.36	GO:0034707	chloride channel complex
0.34	GO:0012505	endomembrane system
0.34	GO:0043230	extracellular organelle
0.33	GO:0005615	extracellular space

sp|O95502|NPTXR_HUMAN
Neuronal pentraxin receptor
Search

0.94	Neuronal pentraxin with chromo domain

0.59	GO:0008306	associative learning
0.46	GO:0031175	neuron projection development
0.44	GO:0042542	response to hydrogen peroxide
0.40	GO:0023052	signaling
0.39	GO:0007154	cell communication
0.38	GO:0051716	cellular response to stimulus
0.37	GO:0048168	regulation of neuronal synaptic plasticity
0.37	GO:0042752	regulation of circadian rhythm

0.49	GO:0008029	pentraxin receptor activity
0.47	GO:0019903	protein phosphatase binding
0.45	GO:0019904	protein domain specific binding
0.42	GO:0032403	protein complex binding
0.41	GO:0046872	metal ion binding
0.39	GO:0030246	carbohydrate binding

0.50	GO:0005634	nucleus
0.48	GO:0030175	filopodium
0.48	GO:0030426	growth cone
0.47	GO:0043025	neuronal cell body
0.46	GO:0030425	dendrite
0.45	GO:0005576	extracellular region
0.45	GO:0009898	cytoplasmic side of plasma membrane
0.43	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

sp|O95503|CBX6_HUMAN
Chromobox protein homolog 6
Search

CBX6

0.96	Chromobox protein like protein 6

0.59	GO:0000122	negative regulation of transcription by RNA polymerase II
0.44	GO:0016569	covalent chromatin modification
0.41	GO:0016567	protein ubiquitination
0.40	GO:0050790	regulation of catalytic activity
0.39	GO:0002244	hematopoietic progenitor cell differentiation
0.36	GO:0006351	transcription, DNA-templated
0.35	GO:0010714	positive regulation of collagen metabolic process
0.35	GO:0032965	regulation of collagen biosynthetic process
0.34	GO:0045739	positive regulation of DNA repair
0.34	GO:0070301	cellular response to hydrogen peroxide

0.59	GO:0003727	single-stranded RNA binding
0.43	GO:0140034	methylation-dependent protein binding
0.43	GO:0097027	ubiquitin-protein transferase activator activity
0.42	GO:0042393	histone binding
0.35	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
0.34	GO:0008270	zinc ion binding

0.62	GO:0031519	PcG protein complex
0.60	GO:0000792	heterochromatin
0.42	GO:0000152	nuclear ubiquitin ligase complex
0.42	GO:0005654	nucleoplasm
0.41	GO:0000790	nuclear chromatin

0.35

EC:3.5.4

GO:0016814

sp|O95521|PRAM1_HUMAN
PRAME family member 1
Search

0.93	PRAME family member 1

0.79	GO:0045596	negative regulation of cell differentiation
0.79	GO:0008284	positive regulation of cell proliferation
0.78	GO:0043066	negative regulation of apoptotic process
0.72	GO:0045892	negative regulation of transcription, DNA-templated

sp|O95522|PRA12_HUMAN
PRAME family member 12
Search

0.88	PRAME family member 7

0.79	GO:0045596	negative regulation of cell differentiation
0.79	GO:0008284	positive regulation of cell proliferation
0.78	GO:0043066	negative regulation of apoptotic process
0.72	GO:0045892	negative regulation of transcription, DNA-templated

sp|O95528|GTR10_HUMAN
Solute carrier family 2, facilitated glucose transporter member 10
Search

SLC2A10

0.96	Solute carrier family 2, facilitated glucose transporter member 10

0.60	GO:0008643	carbohydrate transport
0.54	GO:0055085	transmembrane transport
0.42	GO:0015992	proton transport
0.40	GO:0030903	notochord development
0.39	GO:0072358	cardiovascular system development

0.56

GO:0022857

transmembrane transporter activity

0.41	GO:0048471	perinuclear region of cytoplasm
0.38	GO:0012505	endomembrane system
0.35	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O95544|NADK_HUMAN
NAD kinase
Search

NADK

0.46	NAD kinase a

0.78	GO:0006741	NADP biosynthetic process
0.72	GO:0019674	NAD metabolic process
0.57	GO:0016310	phosphorylation
0.33	GO:0046034	ATP metabolic process

0.76	GO:0003951	NAD+ kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0005515	protein binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0046872	metal ion binding

0.35	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.76	EC:2.7.1.23	GO:0003951
0.76	KEGG:R00104	GO:0003951

sp|O95551|TYDP2_HUMAN
Tyrosyl-DNA phosphodiesterase 2
Search

TDP2

0.96	Tyrosyl-DNA phosphodiesterase 2

0.75	GO:0048666	neuron development
0.74	GO:0006302	double-strand break repair
0.44	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.38	GO:1903507	negative regulation of nucleic acid-templated transcription
0.38	GO:0007166	cell surface receptor signaling pathway

0.87	GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity
0.87	GO:0036317	tyrosyl-RNA phosphodiesterase activity
0.72	GO:0003697	single-stranded DNA binding
0.71	GO:0030145	manganese ion binding
0.63	GO:0000287	magnesium ion binding
0.44	GO:0004518	nuclease activity
0.40	GO:0003714	transcription corepressor activity
0.36	GO:0005515	protein binding

0.84	GO:0016605	PML body
0.83	GO:0016235	aggresome
0.48	GO:0005737	cytoplasm
0.44	GO:0005730	nucleolus
0.30	GO:0031224	intrinsic component of membrane

0.44

EC:3.1

GO:0004518

sp|O95561|CA105_HUMAN
Uncharacterized protein C1orf105
Search

0.53	GO:0005515	protein binding
0.49	GO:0003924	GTPase activity
0.48	GO:0032550	purine ribonucleoside binding
0.48	GO:0019001	guanyl nucleotide binding
0.42	GO:0032555	purine ribonucleotide binding
0.42	GO:0035639	purine ribonucleoside triphosphate binding

sp|O95562|SFT2B_HUMAN
Vesicle transport protein SFT2B
Search

SFT2D2

0.69	Vesicle transport protein (Fragment)

0.68	GO:0016192	vesicle-mediated transport
0.65	GO:0015031	protein transport
0.32	GO:0016310	phosphorylation

0.32

GO:0016301

kinase activity

0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

sp|O95563|MPC2_HUMAN
Mitochondrial pyruvate carrier 2
Search

MPC2

0.61	Mitochondrial pyruvate carrier

0.84	GO:0006850	mitochondrial pyruvate transmembrane transport
0.57	GO:0061732	mitochondrial acetyl-CoA biosynthetic process from pyruvate
0.54	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus

0.58

GO:0050833

pyruvate transmembrane transporter activity

0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane
0.46	GO:0031301	integral component of organelle membrane
0.34	GO:0005634	nucleus

sp|O95567|CV031_HUMAN
Uncharacterized protein C22orf31
Search

sp|O95568|MET18_HUMAN
Histidine protein methyltransferase 1 homolog
Search

METTL18

0.95	Histidine protein methyltransferase 1

0.56

GO:0032259

methylation

0.62	GO:0031072	heat shock protein binding
0.57	GO:0008168	methyltransferase activity

0.50	GO:0043234	protein complex
0.32	GO:0005634	nucleus
0.32	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

0.57

GO:0008168

sp|O95571|ETHE1_HUMAN
Persulfide dioxygenase ETHE1, mitochondrial
Search

ETHE1

0.93	Metallo-beta-lactamase domain-containing protein 2

0.59	GO:0070813	hydrogen sulfide metabolic process
0.58	GO:0006749	glutathione metabolic process
0.50	GO:0055114	oxidation-reduction process
0.34	GO:0009651	response to salt stress
0.33	GO:0006351	transcription, DNA-templated

0.71	GO:0050313	sulfur dioxygenase activity
0.50	GO:0005506	iron ion binding
0.38	GO:0008201	heparin binding
0.38	GO:0016787	hydrolase activity

0.56	GO:0005654	nucleoplasm
0.50	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

0.71

EC:1.13.11.18

GO:0050313

sp|O95573|ACSL3_HUMAN
Long-chain-fatty-acid--CoA ligase 3
Search

ACSL3

0.89	Long-chain-fatty-acid--CoA ligase 3

0.50	GO:0034379	very-low-density lipoprotein particle assembly
0.50	GO:2001247	positive regulation of phosphatidylcholine biosynthetic process
0.49	GO:0044539	long-chain fatty acid import
0.49	GO:0042998	positive regulation of Golgi to plasma membrane protein transport
0.47	GO:0001676	long-chain fatty acid metabolic process
0.47	GO:0051047	positive regulation of secretion
0.41	GO:0007584	response to nutrient
0.41	GO:0007420	brain development
0.40	GO:0014070	response to organic cyclic compound
0.39	GO:0006633	fatty acid biosynthetic process

0.62	GO:0016874	ligase activity
0.46	GO:0019901	protein kinase binding
0.45	GO:0019904	protein domain specific binding
0.36	GO:0030554	adenyl nucleotide binding
0.36	GO:0032555	purine ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding

0.47	GO:0005811	lipid droplet
0.46	GO:0048471	perinuclear region of cytoplasm
0.44	GO:0005783	endoplasmic reticulum
0.43	GO:0005794	Golgi apparatus
0.42	GO:0031903	microbody membrane
0.42	GO:0044439	peroxisomal part
0.42	GO:0005741	mitochondrial outer membrane
0.41	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.40	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.62

GO:0016874

sp|O95600|KLF8_HUMAN
Krueppel-like factor 8
Search

KLF8

0.97	Kruppel like factor 8

0.56	GO:0000122	negative regulation of transcription by RNA polymerase II
0.41	GO:0021684	cerebellar granular layer formation
0.41	GO:0021702	cerebellar Purkinje cell differentiation
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:1901653	cellular response to peptide

0.56	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.56	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.54	GO:0000987	proximal promoter sequence-specific DNA binding
0.34	GO:0046872	metal ion binding
0.32	GO:0005515	protein binding

0.58	GO:0016235	aggresome
0.52	GO:0005654	nucleoplasm
0.49	GO:0005829	cytosol

sp|O95602|RPA1_HUMAN
DNA-directed RNA polymerase I subunit RPA1
Search

POLR1A

0.49	DNA-directed RNA polymerase subunit

0.66	GO:1904750	negative regulation of protein localization to nucleolus
0.60	GO:0006360	transcription by RNA polymerase I
0.44	GO:0048703	embryonic viscerocranium morphogenesis
0.43	GO:0014032	neural crest cell development
0.37	GO:0040029	regulation of gene expression, epigenetic
0.36	GO:0009303	rRNA transcription
0.35	GO:0006354	DNA-templated transcription, elongation
0.35	GO:0016458	gene silencing
0.35	GO:0006353	DNA-templated transcription, termination
0.35	GO:0010628	positive regulation of gene expression

0.69	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.62	GO:0008270	zinc ion binding
0.55	GO:0003682	chromatin binding
0.54	GO:0003677	DNA binding
0.35	GO:0005515	protein binding
0.33	GO:0008373	sialyltransferase activity

0.60	GO:0005634	nucleus
0.55	GO:0000428	DNA-directed RNA polymerase complex
0.51	GO:0031974	membrane-enclosed lumen
0.46	GO:0043232	intracellular non-membrane-bounded organelle
0.45	GO:0044446	intracellular organelle part

0.69

EC:2.7.7.6

GO:0003899

sp|O95613|PCNT_HUMAN
Pericentrin
Search

PCNT

0.79	Pericentrin

0.70	GO:0090316	positive regulation of intracellular protein transport
0.69	GO:0007052	mitotic spindle organization
0.67	GO:0060271	cilium assembly
0.61	GO:0007165	signal transduction
0.46	GO:0000086	G2/M transition of mitotic cell cycle
0.45	GO:0010389	regulation of G2/M transition of mitotic cell cycle
0.44	GO:0140056	organelle localization by membrane tethering
0.33	GO:1990403	embryonic brain development
0.33	GO:0021772	olfactory bulb development
0.33	GO:0021696	cerebellar cortex morphogenesis

0.81	GO:0032947	protein complex scaffold activity
0.44	GO:0005516	calmodulin binding
0.37	GO:0003677	DNA binding
0.32	GO:0003779	actin binding
0.31	GO:0003723	RNA binding
0.30	GO:0003824	catalytic activity

0.73	GO:0034451	centriolar satellite
0.69	GO:0005814	centriole
0.59	GO:0005829	cytosol
0.43	GO:0005874	microtubule
0.33	GO:0000242	pericentriolar material
0.33	GO:0045171	intercellular bridge
0.33	GO:0036064	ciliary basal body
0.33	GO:0005801	cis-Golgi network
0.33	GO:0031514	motile cilium
0.30	GO:0016020	membrane

sp|O95619|YETS4_HUMAN
YEATS domain-containing protein 4
Search

YEATS4

0.94	YEATS domain-containing protein 4

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.54	GO:0043968	histone H2A acetylation
0.54	GO:0043967	histone H4 acetylation
0.37	GO:0006413	translational initiation
0.36	GO:0040008	regulation of growth
0.34	GO:0000278	mitotic cell cycle
0.34	GO:1902680	positive regulation of RNA biosynthetic process
0.34	GO:0007010	cytoskeleton organization

0.53	GO:0008022	protein C-terminus binding
0.37	GO:0003743	translation initiation factor activity
0.34	GO:0005200	structural constituent of cytoskeleton
0.33	GO:0003700	DNA binding transcription factor activity
0.33	GO:0003796	lysozyme activity
0.32	GO:0003677	DNA binding
0.32	GO:0003735	structural constituent of ribosome

0.82	GO:0000812	Swr1 complex
0.78	GO:0035267	NuA4 histone acetyltransferase complex
0.52	GO:0031965	nuclear membrane
0.35	GO:0016363	nuclear matrix
0.34	GO:0005849	mRNA cleavage factor complex
0.32	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

0.33

EC:3.2.1.17

GO:0003796

sp|O95620|DUS4L_HUMAN
tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like
Search

DUS4L

0.54	tRNA-dihydrouridine synthase

0.77	GO:0002943	tRNA dihydrouridine synthesis
0.53	GO:0055114	oxidation-reduction process
0.33	GO:1902358	sulfate transmembrane transport
0.32	GO:0006886	intracellular protein transport

0.77	GO:0017150	tRNA dihydrouridine synthase activity
0.66	GO:0050660	flavin adenine dinucleotide binding
0.33	GO:0008271	secondary active sulfate transmembrane transporter activity

0.32	GO:0005783	endoplasmic reticulum
0.30	GO:0016021	integral component of membrane

sp|O95622|ADCY5_HUMAN
Adenylate cyclase type 5
Search

ADCY5

0.91	Adenylate cyclase type 5

0.79	GO:0006171	cAMP biosynthetic process
0.62	GO:0035556	intracellular signal transduction
0.61	GO:1904321	response to forskolin
0.58	GO:1901655	cellular response to ketone
0.58	GO:0007212	dopamine receptor signaling pathway
0.57	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
0.56	GO:0035690	cellular response to drug
0.54	GO:0071396	cellular response to lipid
0.54	GO:0071407	cellular response to organic cyclic compound
0.54	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus

0.79	GO:0004016	adenylate cyclase activity
0.55	GO:0008179	adenylate cyclase binding
0.54	GO:0097110	scaffold protein binding
0.52	GO:1901265	nucleoside phosphate binding
0.51	GO:0036094	small molecule binding
0.50	GO:0097367	carbohydrate derivative binding
0.50	GO:0008144	drug binding
0.49	GO:0043168	anion binding
0.49	GO:0004383	guanylate cyclase activity
0.48	GO:0046982	protein heterodimerization activity

0.55	GO:0005886	plasma membrane
0.51	GO:0005929	cilium
0.50	GO:0008074	guanylate cyclase complex, soluble
0.50	GO:0045111	intermediate filament cytoskeleton
0.36	GO:0098857	membrane microdomain
0.36	GO:0005768	endosome
0.34	GO:0005902	microvillus
0.34	GO:0120038	plasma membrane bounded cell projection part
0.30	GO:0016021	integral component of membrane

0.79

EC:4.6.1.1

GO:0004016

sp|O95625|ZBT11_HUMAN
Zinc finger and BTB domain-containing protein 11
Search

ZBTB11

0.97	Zinc finger and BTB domain-containing protein 11

0.33	GO:0006351	transcription, DNA-templated
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0010468	regulation of gene expression

0.51	GO:0003676	nucleic acid binding
0.33	GO:0046872	metal ion binding

0.53	GO:0005654	nucleoplasm
0.31	GO:0005856	cytoskeleton

sp|O95626|AN32D_HUMAN
Acidic leucine-rich nuclear phosphoprotein 32 family member D
Search

0.74	Acidic leucine-rich nuclear phosphoprotein 32 family member D

0.71	GO:0006913	nucleocytoplasmic transport
0.70	GO:0043486	histone exchange
0.66	GO:0006334	nucleosome assembly
0.63	GO:0042981	regulation of apoptotic process
0.44	GO:0006351	transcription, DNA-templated
0.44	GO:1903506	regulation of nucleic acid-templated transcription
0.44	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.43	GO:0010468	regulation of gene expression
0.43	GO:0035067	negative regulation of histone acetylation
0.43	GO:0010977	negative regulation of neuron projection development

0.67	GO:0042393	histone binding
0.43	GO:0005178	integrin binding
0.42	GO:0008022	protein C-terminus binding
0.40	GO:0003723	RNA binding

0.73	GO:0048471	perinuclear region of cytoplasm
0.65	GO:0005783	endoplasmic reticulum
0.61	GO:0005634	nucleus
0.49	GO:0031974	membrane-enclosed lumen
0.44	GO:0044446	intracellular organelle part
0.39	GO:0005829	cytosol

sp|O95628|CNOT4_HUMAN
CCR4-NOT transcription complex subunit 4
Search

CNOT4

0.91	CCR4-NOT transcription complex subunit 4

0.54	GO:0051865	protein autoubiquitination
0.46	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
0.36	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.33	GO:0006351	transcription, DNA-templated

0.58	GO:0003723	RNA binding
0.53	GO:0046872	metal ion binding
0.50	GO:0004842	ubiquitin-protein transferase activity
0.33	GO:0005515	protein binding
0.32	GO:0004871	signal transducer activity
0.32	GO:0003700	DNA binding transcription factor activity

0.54	GO:0030014	CCR4-NOT complex
0.35	GO:0005634	nucleus
0.34	GO:0005829	cytosol

0.50

GO:0004842

sp|O95630|STABP_HUMAN
STAM-binding protein
Search

STAMBP

0.94	STAM binding protein a

0.78	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
0.73	GO:0046580	negative regulation of Ras protein signal transduction
0.71	GO:0000281	mitotic cytokinesis
0.68	GO:0016579	protein deubiquitination
0.65	GO:0043524	negative regulation of neuron apoptotic process
0.39	GO:0007259	JAK-STAT cascade
0.39	GO:0035335	peptidyl-tyrosine dephosphorylation
0.38	GO:0008284	positive regulation of cell proliferation
0.36	GO:0006915	apoptotic process
0.35	GO:0006955	immune response

0.69	GO:0004843	thiol-dependent ubiquitin-specific protease activity
0.67	GO:0019904	protein domain specific binding
0.42	GO:0008237	metallopeptidase activity
0.40	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.39	GO:0004725	protein tyrosine phosphatase activity
0.38	GO:0046872	metal ion binding
0.35	GO:0004888	transmembrane signaling receptor activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.75	GO:0097610	cell surface furrow
0.72	GO:0032155	cell division site part
0.62	GO:0005654	nucleoplasm
0.61	GO:0005829	cytosol
0.51	GO:0005886	plasma membrane
0.42	GO:0005768	endosome
0.41	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.40

GO:0008138

sp|O95631|NET1_HUMAN
Netrin-1
Search

NTN1

0.91	Putative extracellular matrix glycoprotein laminin subunit beta (Fragment)

0.59	GO:0030516	regulation of axon extension
0.57	GO:0033564	anterior/posterior axon guidance
0.54	GO:0071678	olfactory bulb axon guidance
0.53	GO:0021960	anterior commissure morphogenesis
0.53	GO:0048562	embryonic organ morphogenesis
0.51	GO:0048732	gland development
0.51	GO:0051093	negative regulation of developmental process
0.51	GO:0051241	negative regulation of multicellular organismal process
0.51	GO:0060562	epithelial tube morphogenesis
0.51	GO:0050772	positive regulation of axonogenesis

0.38

GO:0005515

protein binding

0.65	GO:0005576	extracellular region
0.37	GO:0005737	cytoplasm
0.34	GO:0012505	endomembrane system
0.33	GO:0071944	cell periphery
0.33	GO:0043227	membrane-bounded organelle
0.33	GO:0043229	intracellular organelle
0.30	GO:0016021	integral component of membrane

sp|O95633|FSTL3_HUMAN
Follistatin-related protein 3
Search

FSTL3

0.95	Follistatin-like 3 (Secreted glycoprotein)

0.85	GO:0032926	negative regulation of activin receptor signaling pathway
0.85	GO:0030514	negative regulation of BMP signaling pathway
0.84	GO:0045671	negative regulation of osteoclast differentiation
0.80	GO:0002244	hematopoietic progenitor cell differentiation
0.79	GO:0030325	adrenal gland development
0.76	GO:0008584	male gonad development
0.75	GO:0030324	lung development
0.75	GO:0071248	cellular response to metal ion
0.74	GO:0001822	kidney development
0.73	GO:0022409	positive regulation of cell-cell adhesion

0.87	GO:0048185	activin binding
0.84	GO:0001968	fibronectin binding

0.76	GO:0044306	neuron projection terminus
0.73	GO:0005615	extracellular space
0.73	GO:0030141	secretory granule
0.70	GO:0005654	nucleoplasm
0.65	GO:0005794	Golgi apparatus
0.52	GO:0005788	endoplasmic reticulum lumen

sp|O95639|CPSF4_HUMAN
Cleavage and polyadenylation specificity factor subunit 4
Search

CPSF4

0.63	Cleavage and polyadenylation specificity factor subunit 4

0.51	GO:0098789	pre-mRNA cleavage required for polyadenylation
0.48	GO:0006378	mRNA polyadenylation
0.48	GO:0042462	eye photoreceptor cell development
0.45	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.36	GO:0006369	termination of RNA polymerase II transcription
0.36	GO:0042254	ribosome biogenesis
0.35	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation
0.35	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.35	GO:0046778	modification by virus of host mRNA processing
0.35	GO:0051028	mRNA transport

0.61	GO:0008270	zinc ion binding
0.50	GO:0003676	nucleic acid binding
0.45	GO:0004521	endoribonuclease activity
0.34	GO:0005515	protein binding
0.32	GO:0051537	2 iron, 2 sulfur cluster binding

0.57	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
0.37	GO:0005730	nucleolus
0.35	GO:0030529	intracellular ribonucleoprotein complex

sp|O95644|NFAC1_HUMAN
Nuclear factor of activated T-cells, cytoplasmic 1
Search

NFATC1

0.97	Nuclear factor of activated T cells c

0.59	GO:0033173	calcineurin-NFAT signaling cascade
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:1902680	positive regulation of RNA biosynthetic process
0.40	GO:0009612	response to mechanical stimulus
0.40	GO:0060854	branching involved in lymph vessel morphogenesis
0.40	GO:0002337	B-1a B cell differentiation
0.40	GO:0003180	aortic valve morphogenesis
0.39	GO:0014883	transition between fast and slow fiber

0.61	GO:0003700	DNA binding transcription factor activity
0.54	GO:0003677	DNA binding
0.42	GO:0001225	RNA polymerase II transcription coactivator binding
0.42	GO:0048273	mitogen-activated protein kinase p38 binding
0.41	GO:0001067	regulatory region nucleic acid binding
0.40	GO:0001085	RNA polymerase II transcription factor binding
0.37	GO:0003682	chromatin binding
0.36	GO:0005528	FK506 binding

0.53	GO:0016604	nuclear body
0.52	GO:0000790	nuclear chromatin
0.37	GO:0005667	transcription factor complex
0.35	GO:0005829	cytosol

sp|O95661|DIRA3_HUMAN
GTP-binding protein Di-Ras3
Search

DIRAS3

0.75	GTP-binding protein Di-Ras3

0.59	GO:0007165	signal transduction
0.39	GO:0006349	regulation of gene expression by genetic imprinting
0.38	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
0.38	GO:0032456	endocytic recycling
0.37	GO:0032008	positive regulation of TOR signaling
0.34	GO:0071851	mitotic G1 cell cycle arrest in response to nitrogen starvation
0.34	GO:1905541	regulation of L-arginine import across plasma membrane
0.34	GO:1901042	positive regulation of L-arginine import
0.34	GO:1903961	positive regulation of anion transmembrane transport
0.34	GO:0015819	lysine transport

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005515	protein binding
0.33	GO:0046872	metal ion binding

0.37	GO:0010008	endosome membrane
0.36	GO:0005886	plasma membrane
0.33	GO:0019898	extrinsic component of membrane
0.33	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

sp|O95665|NTR2_HUMAN
Neurotensin receptor type 2
Search

NTSR2

0.97	Low affinity neurotensin receptor

0.79	GO:0007218	neuropeptide signaling pathway
0.63	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
0.59	GO:0042391	regulation of membrane potential
0.44	GO:0008344	adult locomotory behavior
0.43	GO:0043066	negative regulation of apoptotic process
0.39	GO:0007600	sensory perception
0.39	GO:0010562	positive regulation of phosphorus metabolic process
0.39	GO:0009967	positive regulation of signal transduction
0.38	GO:0014054	positive regulation of gamma-aminobutyric acid secretion
0.38	GO:0090238	positive regulation of arachidonic acid secretion

0.86	GO:0016492	G-protein coupled neurotensin receptor activity
0.43	GO:0042802	identical protein binding
0.39	GO:0004990	oxytocin receptor activity
0.38	GO:0005000	vasopressin receptor activity
0.38	GO:0046982	protein heterodimerization activity
0.37	GO:0047485	protein N-terminus binding
0.33	GO:0019958	C-X-C chemokine binding
0.33	GO:0016494	C-X-C chemokine receptor activity
0.33	GO:0015026	coreceptor activity
0.33	GO:0005044	scavenger receptor activity

0.43	GO:0098857	membrane microdomain
0.41	GO:0005887	integral component of plasma membrane
0.40	GO:0043198	dendritic shaft
0.40	GO:0043204	perikaryon
0.38	GO:0009986	cell surface
0.38	GO:0032280	symmetric synapse
0.37	GO:0005794	Golgi apparatus
0.37	GO:0043195	terminal bouton
0.37	GO:0043197	dendritic spine
0.36	GO:0009898	cytoplasmic side of plasma membrane

sp|O95670|VATG2_HUMAN
V-type proton ATPase subunit G 2
Search

ATP6V1G2

0.68	V-type proton ATPase subunit G

0.62	GO:0015992	proton transport
0.55	GO:0055085	transmembrane transport
0.47	GO:0036295	cellular response to increased oxygen levels
0.44	GO:0006879	cellular iron ion homeostasis
0.37	GO:0090383	phagosome acidification
0.37	GO:0033572	transferrin transport
0.36	GO:0008286	insulin receptor signaling pathway
0.36	GO:0016241	regulation of macroautophagy

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.48	GO:0022853	active ion transmembrane transporter activity
0.47	GO:0051117	ATPase binding
0.45	GO:0015078	hydrogen ion transmembrane transporter activity

0.82	GO:0016471	vacuolar proton-transporting V-type ATPase complex
0.54	GO:0030285	integral component of synaptic vesicle membrane
0.43	GO:0005765	lysosomal membrane
0.42	GO:0005829	cytosol
0.40	GO:0042470	melanosome
0.39	GO:0005886	plasma membrane
0.34	GO:0070062	extracellular exosome

sp|O95671|ASML_HUMAN
N-acetylserotonin O-methyltransferase-like protein
Search

ASMTL

0.95	Acetylserotonin O-methyltransferase like

0.62	GO:0032259	methylation
0.38	GO:0030187	melatonin biosynthetic process
0.35	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
0.33	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.33	GO:0006913	nucleocytoplasmic transport
0.32	GO:0055085	transmembrane transport

0.74	GO:0047429	nucleoside-triphosphate diphosphatase activity
0.71	GO:0008171	O-methyltransferase activity
0.36	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
0.35	GO:0005515	protein binding
0.35	GO:0045028	G-protein coupled purinergic nucleotide receptor activity
0.32	GO:0022857	transmembrane transporter activity
0.32	GO:0003676	nucleic acid binding

0.44	GO:0005829	cytosol
0.32	GO:0031966	mitochondrial membrane
0.32	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.74

EC:3.6.1.19

GO:0047429

sp|O95672|ECEL1_HUMAN
Endothelin-converting enzyme-like 1
Search

ECEL1

0.90	Endothelin converting enzyme like 1

0.80	GO:0007218	neuropeptide signaling pathway
0.61	GO:0003016	respiratory system process
0.61	GO:0006508	proteolysis
0.34	GO:0035556	intracellular signal transduction

0.70	GO:0004222	metalloendopeptidase activity
0.35	GO:0046872	metal ion binding

0.36	GO:0005887	integral component of plasma membrane
0.32	GO:0005622	intracellular

0.70

GO:0004222

sp|O95674|CDS2_HUMAN
Phosphatidate cytidylyltransferase 2
Search

CDS2

0.48	Phosphatidate cytidylyltransferase

0.78	GO:0016024	CDP-diacylglycerol biosynthetic process
0.47	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway
0.46	GO:0006655	phosphatidylglycerol biosynthetic process
0.46	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.45	GO:0001525	angiogenesis
0.44	GO:0006661	phosphatidylinositol biosynthetic process
0.35	GO:0007602	phototransduction
0.34	GO:0006657	CDP-choline pathway
0.34	GO:0070085	glycosylation
0.33	GO:0006511	ubiquitin-dependent protein catabolic process

0.79	GO:0004605	phosphatidate cytidylyltransferase activity
0.35	GO:0004142	diacylglycerol cholinephosphotransferase activity

0.52	GO:0005783	endoplasmic reticulum
0.45	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.43	GO:0031984	organelle subcompartment
0.35	GO:0031966	mitochondrial membrane
0.35	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.79

EC:2.7.7.41

GO:0004605

sp|O95677|EYA4_HUMAN
Eyes absent homolog 4
Search

EYA4

0.75	Eyes absent homolog

0.82	GO:0007605	sensory perception of sound
0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.69	GO:0007275	multicellular organism development
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.48	GO:0016576	histone dephosphorylation
0.47	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
0.46	GO:0045739	positive regulation of DNA repair
0.44	GO:0030154	cell differentiation

0.75	GO:0004725	protein tyrosine phosphatase activity
0.54	GO:0046872	metal ion binding
0.36	GO:0008134	transcription factor binding
0.33	GO:0003735	structural constituent of ribosome
0.33	GO:0008289	lipid binding

0.39	GO:0005634	nucleus
0.33	GO:0005737	cytoplasm
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0043232	intracellular non-membrane-bounded organelle

0.75

EC:3.1.3.48

GO:0004725

sp|O95678|K2C75_HUMAN
Keratin, type II cytoskeletal 75
Search

KRT75

0.81	Keratin, type II cytoskeletal 5

0.51	GO:0002244	hematopoietic progenitor cell differentiation
0.43	GO:0031424	keratinization
0.40	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
0.39	GO:0045104	intermediate filament cytoskeleton organization
0.39	GO:0050830	defense response to Gram-positive bacterium
0.39	GO:0043901	negative regulation of multi-organism process
0.38	GO:0044139	modulation of growth of symbiont on or near host
0.38	GO:0012501	programmed cell death
0.38	GO:0002009	morphogenesis of an epithelium
0.38	GO:0001898	regulation of cytolysis by symbiont of host cells

0.62	GO:0005198	structural molecule activity
0.50	GO:0097110	scaffold protein binding

0.83	GO:0045095	keratin filament
0.42	GO:0070062	extracellular exosome
0.40	GO:0005739	mitochondrion
0.39	GO:0005886	plasma membrane
0.37	GO:0005829	cytosol
0.34	GO:0005634	nucleus
0.33	GO:0036338	viral membrane

sp|O95684|FR1OP_HUMAN
FGFR1 oncogene partner
Search

FGFR1OP

0.91	FGFR1 oncogene partner isoform a

0.84	GO:0034453	microtubule anchoring
0.60	GO:0061099	negative regulation of protein tyrosine kinase activity
0.58	GO:0030307	positive regulation of cell growth
0.56	GO:0030335	positive regulation of cell migration
0.55	GO:0008284	positive regulation of cell proliferation
0.40	GO:0030030	cell projection organization
0.37	GO:0000086	G2/M transition of mitotic cell cycle
0.36	GO:0010389	regulation of G2/M transition of mitotic cell cycle
0.36	GO:0140056	organelle localization by membrane tethering
0.36	GO:0018108	peptidyl-tyrosine phosphorylation

0.63	GO:0030292	protein tyrosine kinase inhibitor activity
0.55	GO:0019901	protein kinase binding
0.53	GO:0042803	protein homodimerization activity
0.51	GO:0005509	calcium ion binding
0.36	GO:0004713	protein tyrosine kinase activity

0.75	GO:0005815	microtubule organizing center
0.55	GO:0048471	perinuclear region of cytoplasm
0.46	GO:0005634	nucleus
0.39	GO:0042995	cell projection
0.35	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.36

GO:0004713

sp|O95685|PPR3D_HUMAN
Protein phosphatase 1 regulatory subunit 3D
Search

PPP1R3D

0.85	LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 3D-like

0.75	GO:0005977	glycogen metabolic process
0.45	GO:0005981	regulation of glycogen catabolic process
0.45	GO:0005979	regulation of glycogen biosynthetic process
0.40	GO:0006470	protein dephosphorylation

0.41	GO:0004722	protein serine/threonine phosphatase activity
0.40	GO:0019899	enzyme binding

0.46	GO:0042587	glycogen granule
0.37	GO:0043231	intracellular membrane-bounded organelle

sp|O95696|BRD1_HUMAN
Bromodomain-containing protein 1
Search

BRD1

0.91	Bromodomain-containing protein 1

0.49	GO:0043966	histone H3 acetylation
0.45	GO:0035902	response to immobilization stress
0.45	GO:0051602	response to electrical stimulus

0.54	GO:0046872	metal ion binding
0.47	GO:0042393	histone binding

0.50	GO:0070776	MOZ/MORF histone acetyltransferase complex
0.47	GO:0016607	nuclear speck
0.44	GO:0043204	perikaryon
0.42	GO:0030425	dendrite

sp|O95704|APBB3_HUMAN
Amyloid beta A4 precursor protein-binding family B member 3
Search

APBB3

0.97	Amyloid beta precursor protein binding family B member 3

0.48	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.48	GO:1903506	regulation of nucleic acid-templated transcription
0.47	GO:0010468	regulation of gene expression
0.39	GO:0043066	negative regulation of apoptotic process
0.36	GO:0030308	negative regulation of cell growth
0.36	GO:0007050	cell cycle arrest

0.67	GO:0001540	amyloid-beta binding
0.58	GO:0008134	transcription factor binding
0.36	GO:0005540	hyaluronic acid binding

0.69	GO:0015629	actin cytoskeleton
0.64	GO:0005829	cytosol
0.50	GO:0005634	nucleus
0.36	GO:0030426	growth cone
0.36	GO:0030027	lamellipodium
0.35	GO:0045202	synapse

sp|O95707|RPP29_HUMAN
Ribonuclease P protein subunit p29
Search

POP4

0.88	POP4 homolog, ribonuclease P/MRP subunit

0.81	GO:0006379	mRNA cleavage
0.69	GO:0001682	tRNA 5'-leader removal
0.69	GO:0006364	rRNA processing
0.63	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

0.70	GO:0004540	ribonuclease activity
0.63	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
0.59	GO:0003723	RNA binding
0.59	GO:0140101	catalytic activity, acting on a tRNA

0.85	GO:0030681	multimeric ribonuclease P complex
0.84	GO:0000172	ribonuclease MRP complex
0.77	GO:0044452	nucleolar part
0.30	GO:0031224	intrinsic component of membrane

0.63

EC:3.1.30

GO:0016893

sp|O95711|LY86_HUMAN
Lymphocyte antigen 86
Search

LY86

0.96	Lymphocyte antigen 86

0.87	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
0.45	GO:0006954	inflammatory response
0.45	GO:0045087	innate immune response
0.42	GO:0006959	humoral immune response
0.41	GO:0008283	cell proliferation
0.41	GO:0006915	apoptotic process

0.42

GO:0005515

protein binding

0.43	GO:0005615	extracellular space
0.36	GO:0005886	plasma membrane

sp|O95714|HERC2_HUMAN
E3 ubiquitin-protein ligase HERC2
Search

LOC108933171

0.59	E3 ubiquitin-protein ligase HERC2

0.72	GO:0016567	protein ubiquitination
0.37	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.35	GO:0007283	spermatogenesis
0.34	GO:0006974	cellular response to DNA damage stimulus
0.33	GO:0006259	DNA metabolic process
0.33	GO:0006886	intracellular protein transport
0.33	GO:0065009	regulation of molecular function

0.73	GO:0004842	ubiquitin-protein transferase activity
0.62	GO:0008270	zinc ion binding
0.61	GO:0016874	ligase activity
0.37	GO:0032183	SUMO binding
0.37	GO:0061659	ubiquitin-like protein ligase activity
0.36	GO:0031625	ubiquitin protein ligase binding
0.33	GO:0005085	guanyl-nucleotide exchange factor activity

0.35	GO:0005814	centriole
0.35	GO:0005634	nucleus
0.33	GO:0031966	mitochondrial membrane
0.33	GO:0019866	organelle inner membrane
0.33	GO:0031974	membrane-enclosed lumen

0.61	EC:6	GO:0016874
0.73	KEGG:R03876	GO:0004842

sp|O95715|CXL14_HUMAN
C-X-C motif chemokine 14
Search

CXCL14

0.97	C-X-C motif chemokine ligand 14

0.82	GO:0060326	cell chemotaxis
0.74	GO:0006955	immune response
0.64	GO:2000503	positive regulation of natural killer cell chemotaxis
0.62	GO:0045662	negative regulation of myoblast differentiation
0.59	GO:0048839	inner ear development
0.47	GO:0007267	cell-cell signaling
0.37	GO:0031640	killing of cells of other organism
0.37	GO:0010469	regulation of receptor activity
0.36	GO:0043207	response to external biotic stimulus
0.34	GO:0007165	signal transduction

0.84	GO:0008009	chemokine activity
0.34	GO:0046983	protein dimerization activity

0.66	GO:0005576	extracellular region
0.53	GO:0005794	Golgi apparatus
0.30	GO:0016020	membrane

sp|O95716|RAB3D_HUMAN
Ras-related protein Rab-3D
Search

RAB3D

0.88	Synaptic vesicle specific GTP-binding protein protein

0.57	GO:0018125	peptidyl-cysteine methylation
0.53	GO:0045453	bone resorption
0.52	GO:0017157	regulation of exocytosis
0.50	GO:0051050	positive regulation of transport
0.46	GO:0048522	positive regulation of cellular process
0.41	GO:0097494	regulation of vesicle size
0.40	GO:0051584	regulation of dopamine uptake involved in synaptic transmission
0.40	GO:2001025	positive regulation of response to drug
0.38	GO:0019882	antigen processing and presentation
0.38	GO:0023056	positive regulation of signaling

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.55	GO:0031489	myosin V binding
0.55	GO:0030742	GTP-dependent protein binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.34	GO:0008168	methyltransferase activity
0.32	GO:0046872	metal ion binding

0.53	GO:0042588	zymogen granule
0.50	GO:0005881	cytoplasmic microtubule
0.42	GO:0005739	mitochondrion
0.41	GO:0030133	transport vesicle
0.38	GO:0048471	perinuclear region of cytoplasm
0.38	GO:0098793	presynapse
0.36	GO:0070062	extracellular exosome
0.35	GO:0035577	azurophil granule membrane
0.34	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0004114

sp|O95718|ERR2_HUMAN
Steroid hormone receptor ERR2
Search

ESRRB

0.93	Estrogen-related receptor beta type 1

0.76	GO:0043401	steroid hormone mediated signaling pathway
0.57	GO:0048384	retinoic acid receptor signaling pathway
0.57	GO:0006351	transcription, DNA-templated
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:2001141	regulation of RNA biosynthetic process
0.55	GO:0019827	stem cell population maintenance
0.55	GO:0010468	regulation of gene expression
0.47	GO:0045935	positive regulation of nucleobase-containing compound metabolic process
0.47	GO:0010557	positive regulation of macromolecule biosynthetic process
0.47	GO:0031328	positive regulation of cellular biosynthetic process

0.79	GO:0005496	steroid binding
0.77	GO:0003707	steroid hormone receptor activity
0.63	GO:0043565	sequence-specific DNA binding
0.61	GO:0008270	zinc ion binding
0.60	GO:0003700	DNA binding transcription factor activity
0.49	GO:0001012	RNA polymerase II regulatory region DNA binding
0.46	GO:0003690	double-stranded DNA binding
0.38	GO:0050682	AF-2 domain binding
0.35	GO:0005516	calmodulin binding

0.60	GO:0005634	nucleus
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part

sp|O95721|SNP29_HUMAN
Synaptosomal-associated protein 29
Search

SNAP29

0.96	Synaptosomal-associated protein 29

0.84	GO:0016240	autophagosome membrane docking
0.73	GO:0060271	cilium assembly
0.67	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane
0.66	GO:0016082	synaptic vesicle priming
0.60	GO:0072114	pronephros morphogenesis
0.58	GO:0048730	epidermis morphogenesis
0.44	GO:0015031	protein transport
0.41	GO:0043312	neutrophil degranulation
0.40	GO:0006903	vesicle targeting

0.62	GO:0019905	syntaxin binding
0.61	GO:0005484	SNAP receptor activity

0.85	GO:0020018	ciliary pocket membrane
0.77	GO:0031201	SNARE complex
0.74	GO:0005776	autophagosome
0.71	GO:0005813	centrosome
0.64	GO:0005654	nucleoplasm
0.63	GO:0005829	cytosol
0.60	GO:0098793	presynapse
0.48	GO:0005774	vacuolar membrane
0.47	GO:0000139	Golgi membrane
0.46	GO:0031410	cytoplasmic vesicle

sp|O95727|CRTAM_HUMAN
Cytotoxic and regulatory T-cell molecule
Search

CRTAM

0.97	Cytotoxic and regulatory T-cell molecule

0.76	GO:0002355	detection of tumor cell
0.74	GO:0002857	positive regulation of natural killer cell mediated immune response to tumor cell
0.74	GO:0002858	regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
0.72	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
0.69	GO:0050715	positive regulation of cytokine secretion
0.66	GO:0008037	cell recognition
0.56	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
0.52	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.42	GO:0002250	adaptive immune response
0.41	GO:0050798	activated T cell proliferation

0.60	GO:0005102	receptor binding
0.53	GO:0050839	cell adhesion molecule binding
0.50	GO:0042803	protein homodimerization activity
0.46	GO:0004872	receptor activity
0.32	GO:0005509	calcium ion binding

0.54	GO:0005913	cell-cell adherens junction
0.48	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O95741|CPNE6_HUMAN
Copine-6
Search

CPNE6

0.94	Copine VII

0.84	GO:0071277	cellular response to calcium ion
0.78	GO:1903861	positive regulation of dendrite extension
0.39	GO:0046474	glycerophospholipid biosynthetic process
0.38	GO:0007268	chemical synaptic transmission
0.37	GO:0016192	vesicle-mediated transport
0.35	GO:0006094	gluconeogenesis
0.34	GO:0016310	phosphorylation

0.77	GO:0001786	phosphatidylserine binding
0.41	GO:0005515	protein binding
0.37	GO:0005509	calcium ion binding
0.37	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity
0.36	GO:0005215	transporter activity
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0019001	guanyl nucleotide binding
0.34	GO:0016301	kinase activity
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.74	GO:0045334	clathrin-coated endocytic vesicle
0.72	GO:0030425	dendrite
0.71	GO:0030424	axon
0.55	GO:0005886	plasma membrane
0.49	GO:0043204	perikaryon
0.48	GO:0070062	extracellular exosome
0.46	GO:0005634	nucleus
0.45	GO:0005768	endosome
0.37	GO:0008537	proteasome activator complex

0.37

EC:4.1.1.32

GO:0004613

sp|O95744|PM2P2_HUMAN
Putative postmeiotic segregation increased 2-like protein 2
Search

sp|O95747|OXSR1_HUMAN
Serine/threonine-protein kinase OSR1
Search

OXSR1

0.97	Oxidative-stress responsive 1

0.63	GO:0006468	protein phosphorylation
0.51	GO:0031098	stress-activated protein kinase signaling cascade
0.50	GO:0032147	activation of protein kinase activity
0.48	GO:0007346	regulation of mitotic cell cycle
0.48	GO:0042981	regulation of apoptotic process
0.38	GO:0018210	peptidyl-threonine modification

0.69	GO:0004674	protein serine/threonine kinase activity
0.57	GO:0005057	signal transducer activity, downstream of receptor
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0042802	identical protein binding
0.35	GO:0000287	magnesium ion binding

0.39

GO:0005622

intracellular

0.69

GO:0004674

sp|O95749|GGPPS_HUMAN
Geranylgeranyl pyrophosphate synthase
Search

GGPS1

0.53	Geranylgeranyl pyrophosphate synthetase

0.70	GO:0008299	isoprenoid biosynthetic process
0.41	GO:0033383	geranyl diphosphate metabolic process
0.41	GO:0033385	geranylgeranyl diphosphate metabolic process
0.40	GO:0045338	farnesyl diphosphate metabolic process
0.37	GO:0008654	phospholipid biosynthetic process
0.36	GO:0045540	regulation of cholesterol biosynthetic process
0.35	GO:0006695	cholesterol biosynthetic process

0.54	GO:0004337	geranyltranstransferase activity
0.52	GO:0004311	farnesyltranstransferase activity
0.50	GO:0042802	identical protein binding
0.40	GO:0004161	dimethylallyltranstransferase activity
0.34	GO:0046872	metal ion binding

0.34

GO:0005829

cytosol

0.54	EC:2.5.1.10	GO:0004337
0.54	KEGG:R02003	GO:0004337

sp|O95750|FGF19_HUMAN
Fibroblast growth factor 19
Search

FGF19

0.62	Fibroblast growth factor

0.84	GO:0008543	fibroblast growth factor receptor signaling pathway
0.76	GO:0010469	regulation of receptor activity
0.72	GO:0070858	negative regulation of bile acid biosynthetic process
0.67	GO:0046326	positive regulation of glucose import
0.65	GO:0046330	positive regulation of JNK cascade
0.65	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.63	GO:0008284	positive regulation of cell proliferation
0.54	GO:0010629	negative regulation of gene expression
0.53	GO:0001755	neural crest cell migration
0.50	GO:0007507	heart development

0.85	GO:0005104	fibroblast growth factor receptor binding
0.78	GO:0008083	growth factor activity
0.40	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.39	GO:0016303	1-phosphatidylinositol-3-kinase activity
0.37	GO:0005088	Ras guanyl-nucleotide exchange factor activity

0.66	GO:0005576	extracellular region
0.33	GO:0005622	intracellular
0.30	GO:0016020	membrane

0.40	EC:2.7.1.153	GO:0046934
0.40	KEGG:R04545	GO:0046934

sp|O95751|LDOC1_HUMAN
Protein LDOC1
Search

LDOC1

0.92	Mammalian retrotransposon derived protein 8B

0.63

GO:0005515

protein binding

sp|O95754|SEM4F_HUMAN
Semaphorin-4F
Search

SEMA4F

0.89	Semaphorin-4F isoform B

0.74	GO:0007409	axonogenesis
0.74	GO:0097485	neuron projection guidance
0.53	GO:0050919	negative chemotaxis
0.44	GO:0051093	negative regulation of developmental process
0.44	GO:0051241	negative regulation of multicellular organismal process
0.43	GO:2000026	regulation of multicellular organismal development
0.42	GO:0045063	T-helper 1 cell differentiation
0.42	GO:0071526	semaphorin-plexin signaling pathway
0.42	GO:0061387	regulation of extent of cell growth
0.41	GO:0022604	regulation of cell morphogenesis

0.54	GO:0038191	neuropilin binding
0.36	GO:0030215	semaphorin receptor binding
0.35	GO:0005536	glucose binding
0.34	GO:0004396	hexokinase activity
0.34	GO:0004888	transmembrane signaling receptor activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0008144	drug binding
0.32	GO:0005198	structural molecule activity

0.50	GO:0005783	endoplasmic reticulum
0.48	GO:0005615	extracellular space
0.44	GO:0005886	plasma membrane
0.40	GO:0045202	synapse
0.38	GO:0005829	cytosol
0.37	GO:0005634	nucleus
0.33	GO:0005882	intermediate filament
0.30	GO:0016021	integral component of membrane

0.34

EC:2.7.1.1

GO:0004396

sp|O95755|RAB36_HUMAN
Ras-related protein Rab-36
Search

RAB36

0.97	RAB36, member RAS oncogene family

0.35	GO:0008104	protein localization
0.35	GO:0042886	amide transport
0.34	GO:0006518	peptide metabolic process
0.34	GO:0071702	organic substance transport
0.34	GO:0043604	amide biosynthetic process
0.34	GO:0035023	regulation of Rho protein signal transduction
0.34	GO:0043547	positive regulation of GTPase activity
0.34	GO:0044267	cellular protein metabolic process
0.34	GO:0032482	Rab protein signal transduction
0.34	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.65	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0003735	structural constituent of ribosome
0.34	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.34	GO:0005096	GTPase activator activity

0.37	GO:0045202	synapse
0.36	GO:0005794	Golgi apparatus
0.35	GO:0098588	bounding membrane of organelle
0.35	GO:0031984	organelle subcompartment
0.34	GO:0005840	ribosome
0.33	GO:0005829	cytosol
0.33	GO:0031982	vesicle
0.32	GO:0005801	cis-Golgi network
0.30	GO:0031224	intrinsic component of membrane

sp|O95757|HS74L_HUMAN
Heat shock 70 kDa protein 4L
Search

HSPA4L

0.90	Heat shock protein 4 like

0.45	GO:0045040	protein import into mitochondrial outer membrane
0.44	GO:0051131	chaperone-mediated protein complex assembly
0.37	GO:0006986	response to unfolded protein
0.35	GO:0006457	protein folding

0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding
0.32	GO:0046872	metal ion binding

0.50	GO:0005829	cytosol
0.44	GO:0070062	extracellular exosome
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|O95758|PTBP3_HUMAN
Polypyrimidine tract-binding protein 3
Search

PTBP3

0.91	Polypyrimidine tract-binding protein 3

0.67	GO:0006397	mRNA processing
0.62	GO:0045595	regulation of cell differentiation
0.59	GO:0033119	negative regulation of RNA splicing
0.45	GO:0075522	IRES-dependent viral translational initiation
0.45	GO:0048024	regulation of mRNA splicing, via spliceosome
0.43	GO:0050686	negative regulation of mRNA processing
0.42	GO:0051093	negative regulation of developmental process
0.39	GO:0043249	erythrocyte maturation
0.38	GO:0008380	RNA splicing
0.36	GO:1904411	positive regulation of secretory granule organization

0.58	GO:0003723	RNA binding
0.35	GO:0000014	single-stranded DNA endodeoxyribonuclease activity
0.34	GO:0001067	regulatory region nucleic acid binding
0.34	GO:0003697	single-stranded DNA binding
0.33	GO:0043565	sequence-specific DNA binding

0.59	GO:0005634	nucleus
0.35	GO:0044306	neuron projection terminus
0.34	GO:0070062	extracellular exosome
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|O95759|TBCD8_HUMAN
TBC1 domain family member 8
Search

TBC1D8

0.92	TBC1 domain family, member 8 (With GRAM domain)

0.63	GO:0031338	regulation of vesicle fusion
0.63	GO:0090630	activation of GTPase activity
0.53	GO:0006886	intracellular protein transport
0.43	GO:1902017	regulation of cilium assembly
0.38	GO:0008015	blood circulation
0.38	GO:0008284	positive regulation of cell proliferation

0.64	GO:0005509	calcium ion binding
0.60	GO:0017137	Rab GTPase binding
0.58	GO:0005096	GTPase activator activity
0.34	GO:0048037	cofactor binding

0.52	GO:0012505	endomembrane system
0.39	GO:0005622	intracellular
0.30	GO:0016020	membrane

sp|O95760|IL33_HUMAN
Interleukin-33
Search

IL33

0.97	Interleukin-33

0.76	GO:0010469	regulation of receptor activity
0.71	GO:0090197	positive regulation of chemokine secretion
0.70	GO:0043032	positive regulation of macrophage activation
0.68	GO:0002282	microglial cell activation involved in immune response
0.67	GO:0051025	negative regulation of immunoglobulin secretion
0.67	GO:0061518	microglial cell proliferation
0.66	GO:0002826	negative regulation of T-helper 1 type immune response
0.65	GO:0051024	positive regulation of immunoglobulin secretion
0.65	GO:0032736	positive regulation of interleukin-13 production
0.65	GO:0032754	positive regulation of interleukin-5 production

0.81

GO:0005125

cytokine activity

0.45	GO:0030133	transport vesicle
0.44	GO:0005615	extracellular space
0.42	GO:0005694	chromosome
0.40	GO:0005634	nucleus
0.37	GO:0031974	membrane-enclosed lumen
0.35	GO:0044446	intracellular organelle part

sp|O95772|MENTO_HUMAN
MLN64 N-terminal domain homolog
Search

STARD3NL

0.96	MLN64 N-terminal domain homolog

0.43	GO:0099044	vesicle tethering to endoplasmic reticulum
0.30	GO:1901362	organic cyclic compound biosynthetic process
0.30	GO:0010817	regulation of hormone levels
0.30	GO:0044237	cellular metabolic process
0.30	GO:0044238	primary metabolic process

0.41	GO:0015485	cholesterol binding
0.39	GO:0042803	protein homodimerization activity

0.41	GO:0031902	late endosome membrane
0.41	GO:0044232	organelle membrane contact site
0.39	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane
0.30	GO:0005765	lysosomal membrane
0.30	GO:0005829	cytosol

sp|O95777|LSM8_HUMAN
U6 snRNA-associated Sm-like protein LSm8
Search

LSM8

0.92	N-alpha-acetyltransferase 38, NatC auxiliary subunit

0.75	GO:0000398	mRNA splicing, via spliceosome
0.43	GO:0030217	T cell differentiation

0.41	GO:0016740	transferase activity
0.40	GO:0003723	RNA binding
0.33	GO:0005515	protein binding

0.84	GO:0005688	U6 snRNP
0.81	GO:0046540	U4/U6 x U5 tri-snRNP complex
0.48	GO:0071011	precatalytic spliceosome
0.41	GO:0019013	viral nucleocapsid
0.33	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.41

EC:2

GO:0016740

sp|O95780|ZN682_HUMAN
Zinc finger protein 682
Search

0.76	Zinc finger protein 66

0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.39	GO:0006351	transcription, DNA-templated
0.36	GO:1902679	negative regulation of RNA biosynthetic process
0.33	GO:0035108	limb morphogenesis

0.51	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.40	GO:0003700	DNA binding transcription factor activity

0.44	GO:0005622	intracellular
0.39	GO:0043227	membrane-bounded organelle
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0043228	non-membrane-bounded organelle
0.34	GO:0044422	organelle part

sp|O95782|AP2A1_HUMAN
AP-2 complex subunit alpha-1
Search

AP2A1

0.72	AP-2 complex subunit alpha

0.71	GO:0072583	clathrin-dependent endocytosis
0.69	GO:0006886	intracellular protein transport
0.55	GO:1900126	negative regulation of hyaluronan biosynthetic process
0.44	GO:0060218	hematopoietic stem cell differentiation
0.44	GO:0009950	dorsal/ventral axis specification
0.40	GO:0048260	positive regulation of receptor-mediated endocytosis
0.40	GO:0010976	positive regulation of neuron projection development
0.37	GO:0032802	low-density lipoprotein particle receptor catabolic process
0.37	GO:0034383	low-density lipoprotein particle clearance
0.37	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

0.85	GO:0035615	clathrin adaptor activity
0.68	GO:0008565	protein transporter activity
0.53	GO:0050750	low-density lipoprotein particle receptor binding
0.49	GO:0019901	protein kinase binding
0.40	GO:0008022	protein C-terminus binding
0.38	GO:0032403	protein complex binding
0.36	GO:0097718	disordered domain specific binding

0.78	GO:0030131	clathrin adaptor complex
0.78	GO:0005905	clathrin-coated pit
0.53	GO:0032433	filopodium tip
0.40	GO:0016323	basolateral plasma membrane
0.39	GO:0016324	apical plasma membrane
0.39	GO:0030136	clathrin-coated vesicle
0.37	GO:0036020	endolysosome membrane
0.37	GO:0005794	Golgi apparatus
0.36	GO:0030666	endocytic vesicle membrane
0.36	GO:0030141	secretory granule

sp|O95785|WIZ_HUMAN
Protein Wiz
Search

sp|O95786|DDX58_HUMAN
Probable ATP-dependent RNA helicase DDX58
Search

DDX58

0.85	Retinoic acid inducible protein I

0.62	GO:0039529	RIG-I signaling pathway
0.60	GO:0035549	positive regulation of interferon-beta secretion
0.60	GO:1904469	positive regulation of tumor necrosis factor secretion
0.59	GO:0009597	detection of virus
0.59	GO:1902741	positive regulation of interferon-alpha secretion
0.59	GO:0071360	cellular response to exogenous dsRNA
0.59	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
0.58	GO:2000778	positive regulation of interleukin-6 secretion
0.58	GO:0002230	positive regulation of defense response to virus by host
0.58	GO:0060760	positive regulation of response to cytokine stimulus

0.55	GO:0008270	zinc ion binding
0.54	GO:0030554	adenyl nucleotide binding
0.54	GO:0004386	helicase activity
0.54	GO:0003727	single-stranded RNA binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0031625	ubiquitin protein ligase binding
0.52	GO:0003725	double-stranded RNA binding
0.51	GO:0042802	identical protein binding

0.57	GO:0032587	ruffle membrane
0.54	GO:0005923	bicellular tight junction
0.51	GO:0015629	actin cytoskeleton
0.49	GO:0005829	cytosol
0.35	GO:0005634	nucleus
0.31	GO:0016442	RISC complex
0.30	GO:0016021	integral component of membrane

0.33

EC:3.1.26.3

GO:0004525

sp|O95789|ZMYM6_HUMAN
Zinc finger MYM-type protein 6
Search

ZMYM6

0.97	Zinc finger MYM-type containing 6

0.50	GO:0007010	cytoskeleton organization
0.49	GO:0022604	regulation of cell morphogenesis
0.45	GO:0006357	regulation of transcription by RNA polymerase II
0.45	GO:0007275	multicellular organism development

0.63	GO:0008270	zinc ion binding
0.46	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.39	GO:0003677	DNA binding
0.33	GO:0005515	protein binding

0.45	GO:0005654	nucleoplasm
0.37	GO:0005737	cytoplasm

sp|O95793|STAU1_HUMAN
Double-stranded RNA-binding protein Staufen homolog 1
Search

STAU1

0.90	Double-stranded RNA-binding protein Staufen

0.61	GO:0046726	positive regulation by virus of viral protein levels in host cell
0.59	GO:0045070	positive regulation of viral genome replication
0.44	GO:1900273	positive regulation of long-term synaptic potentiation
0.40	GO:0034599	cellular response to oxidative stress
0.40	GO:0007281	germ cell development
0.40	GO:0008298	intracellular mRNA localization

0.59	GO:0003723	RNA binding
0.43	GO:0008157	protein phosphatase 1 binding

0.55	GO:0030425	dendrite
0.55	GO:0044297	cell body
0.54	GO:0036464	cytoplasmic ribonucleoprotein granule
0.51	GO:0005783	endoplasmic reticulum
0.50	GO:0005829	cytosol
0.43	GO:0005886	plasma membrane
0.40	GO:0070062	extracellular exosome
0.37	GO:0005875	microtubule associated complex

sp|O95800|GPR75_HUMAN
Probable G-protein coupled receptor 75
Search

GPR75

0.89	G protein-coupled receptor 75

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.61	GO:0070098	chemokine-mediated signaling pathway
0.61	GO:1901214	regulation of neuron death

0.71	GO:0004930	G-protein coupled receptor activity
0.60	GO:0004896	cytokine receptor activity
0.58	GO:0001653	peptide receptor activity

0.37

GO:0005887

integral component of plasma membrane

sp|O95801|TTC4_HUMAN
Tetratricopeptide repeat protein 4
Search

TTC4

0.93	Tetratricopeptide repeat protein 4

0.84	GO:0032474	otolith morphogenesis
0.78	GO:0061371	determination of heart left/right asymmetry
0.73	GO:0060271	cilium assembly

0.51

GO:0003779

actin binding

0.30

GO:0031224

intrinsic component of membrane

sp|O95803|NDST3_HUMAN
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
Search

0.97	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

0.55	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
0.40	GO:0030210	heparin biosynthetic process

0.85	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity
0.57	GO:0042328	heparan sulfate N-acetylglucosaminyltransferase activity
0.51	GO:0016787	hydrolase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.37	GO:0000139	Golgi membrane
0.30	GO:0016021	integral component of membrane

0.85

EC:2.8.2.8

GO:0015016

sp|O95807|TM50A_HUMAN
Transmembrane protein 50A
Search

TMEM50A

0.97	Cervical cancer oncogene 9

0.48	GO:0005783	endoplasmic reticulum
0.30	GO:0044425	membrane part

sp|O95810|SDPR_HUMAN
Serum deprivation-response protein
Search

CAVIN2

0.97	Serum deprivation response

0.58	GO:0097320	plasma membrane tubulation
0.51	GO:0006363	termination of RNA polymerase I transcription
0.44	GO:0006361	transcription initiation from RNA polymerase I promoter
0.44	GO:0009303	rRNA transcription
0.42	GO:2000147	positive regulation of cell motility
0.35	GO:0045944	positive regulation of transcription by RNA polymerase II
0.32	GO:0007165	signal transduction

0.58	GO:0001786	phosphatidylserine binding
0.51	GO:0005080	protein kinase C binding
0.44	GO:0042134	rRNA primary transcript binding
0.41	GO:0042802	identical protein binding
0.32	GO:0004871	signal transducer activity
0.32	GO:0003700	DNA binding transcription factor activity
0.31	GO:0003677	DNA binding

0.83	GO:0005901	caveola
0.51	GO:0015629	actin cytoskeleton
0.50	GO:0005654	nucleoplasm
0.49	GO:0005829	cytosol
0.38	GO:0005739	mitochondrion
0.37	GO:0043234	protein complex
0.34	GO:0005783	endoplasmic reticulum
0.30	GO:0016021	integral component of membrane

sp|O95813|CER1_HUMAN
Cerberus
Search

CER1

0.97	Cerberus 1 homolog (Xenopus laevis)

0.76	GO:0035582	sequestering of BMP in extracellular matrix
0.75	GO:2000381	negative regulation of mesoderm development
0.75	GO:0003419	growth plate cartilage chondrocyte proliferation
0.74	GO:0032926	negative regulation of activin receptor signaling pathway
0.74	GO:0048263	determination of dorsal identity
0.72	GO:0023019	signal transduction involved in regulation of gene expression
0.71	GO:0030282	bone mineralization
0.70	GO:0042074	cell migration involved in gastrulation
0.69	GO:0001657	ureteric bud development
0.69	GO:0009948	anterior/posterior axis specification

0.75	GO:0016015	morphogen activity
0.73	GO:0036122	BMP binding
0.61	GO:0042803	protein homodimerization activity
0.41	GO:0005125	cytokine activity
0.36	GO:0017147	Wnt-protein binding
0.35	GO:0038100	nodal binding

0.66	GO:0005576	extracellular region
0.30	GO:0016020	membrane

sp|O95816|BAG2_HUMAN
BAG family molecular chaperone regulator 2
Search

BAG2

0.97	BCL2-associated athanogene 2

0.69	GO:0050790	regulation of catalytic activity
0.47	GO:0006457	protein folding
0.46	GO:0019538	protein metabolic process

0.79	GO:0000774	adenyl-nucleotide exchange factor activity
0.77	GO:0051087	chaperone binding
0.60	GO:0042802	identical protein binding

sp|O95817|BAG3_HUMAN
BAG family molecular chaperone regulator 3
Search

BAG3

0.86	BCL2-associated athanogene 3

0.78	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress
0.77	GO:0010664	negative regulation of striated muscle cell apoptotic process
0.76	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
0.75	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
0.75	GO:0042993	positive regulation of transcription factor import into nucleus
0.75	GO:0046827	positive regulation of protein export from nucleus
0.74	GO:0071260	cellular response to mechanical stimulus
0.70	GO:0034605	cellular response to heat
0.68	GO:0050821	protein stabilization
0.60	GO:0050790	regulation of catalytic activity

0.77	GO:0051087	chaperone binding
0.71	GO:0045296	cadherin binding
0.68	GO:0000774	adenyl-nucleotide exchange factor activity
0.65	GO:0032403	protein complex binding

0.73	GO:0030018	Z disc
0.60	GO:0005829	cytosol
0.55	GO:0005634	nucleus
0.50	GO:0005886	plasma membrane
0.38	GO:0043005	neuron projection

sp|O95819|M4K4_HUMAN
Mitogen-activated protein kinase kinase kinase kinase 4
Search

MAP4K4

0.89	Mitogen-activated protein kinase kinase kinase kinase 4

0.63	GO:0006468	protein phosphorylation
0.47	GO:0046328	regulation of JNK cascade
0.46	GO:0043066	negative regulation of apoptotic process
0.42	GO:0000185	activation of MAPKKK activity
0.41	GO:0035556	intracellular signal transduction
0.41	GO:0120036	plasma membrane bounded cell projection organization
0.41	GO:0048699	generation of neurons
0.41	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.40	GO:0007346	regulation of mitotic cell cycle
0.40	GO:0048468	cell development

0.63	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0004111	creatine kinase activity
0.41	GO:0005057	signal transducer activity, downstream of receptor
0.35	GO:0005515	protein binding

0.37

GO:0005737

cytoplasm

0.50	EC:2.7.3.2	GO:0004111
0.50	KEGG:R01881	GO:0004111

sp|O95822|DCMC_HUMAN
Malonyl-CoA decarboxylase, mitochondrial
Search

MLYCD

0.69	Malonyl-CoA decarboxylase

0.70	GO:0006633	fatty acid biosynthetic process
0.60	GO:2001294	malonyl-CoA catabolic process
0.58	GO:0046321	positive regulation of fatty acid oxidation
0.48	GO:0010906	regulation of glucose metabolic process
0.46	GO:0006085	acetyl-CoA biosynthetic process
0.41	GO:0031998	regulation of fatty acid beta-oxidation
0.40	GO:0002931	response to ischemia
0.38	GO:0019395	fatty acid oxidation

0.85	GO:0050080	malonyl-CoA decarboxylase activity
0.45	GO:0042802	identical protein binding
0.44	GO:0005102	receptor binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003676	nucleic acid binding

0.50	GO:0005759	mitochondrial matrix
0.46	GO:0005777	peroxisome
0.40	GO:0031907	microbody lumen
0.37	GO:0005829	cytosol

0.85

EC:4.1.1.9

GO:0050080

sp|O95825|QORL1_HUMAN
Quinone oxidoreductase-like protein 1
Search

CRYZL1

0.94	Crystallin zeta like 1

0.53

GO:0055114

oxidation-reduction process

0.54

GO:0016491

oxidoreductase activity

0.36	GO:0005829	cytosol
0.30	GO:0044425	membrane part

0.54

GO:0016491

sp|O95831|AIFM1_HUMAN
Apoptosis-inducing factor 1, mitochondrial
Search

AIFM1

0.94	Apoptosis inducing factor mitochondria associated 1

0.79	GO:1902510	regulation of apoptotic DNA fragmentation
0.76	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
0.75	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
0.75	GO:0051402	neuron apoptotic process
0.53	GO:0055114	oxidation-reduction process

0.75	GO:0016174	NAD(P)H oxidase activity
0.68	GO:0046983	protein dimerization activity
0.65	GO:0050660	flavin adenine dinucleotide binding
0.49	GO:0003677	DNA binding

0.70	GO:0005758	mitochondrial intermembrane space
0.60	GO:0005829	cytosol
0.56	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.75

EC:1.6.3.1

GO:0016174

sp|O95832|CLD1_HUMAN
Claudin-1
Search

CLDN1

0.68

Claudin

0.60	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
0.60	GO:0043297	apical junction assembly
0.60	GO:0061436	establishment of skin barrier
0.58	GO:0051291	protein heterooligomerization
0.54	GO:0051260	protein homooligomerization
0.49	GO:0051806	entry into cell of other organism involved in symbiotic interaction
0.49	GO:0044409	entry into host
0.47	GO:0019058	viral life cycle
0.43	GO:0061772	drug transport across blood-nerve barrier
0.43	GO:1903545	cellular response to butyrate

0.62	GO:0005198	structural molecule activity
0.60	GO:0104005	hijacked molecular function
0.51	GO:0042802	identical protein binding
0.33	GO:0005254	chloride channel activity
0.32	GO:0016787	hydrolase activity

0.81	GO:0005923	bicellular tight junction
0.58	GO:0016323	basolateral plasma membrane
0.57	GO:0016328	lateral plasma membrane
0.55	GO:0016324	apical plasma membrane
0.49	GO:0005887	integral component of plasma membrane
0.37	GO:0005634	nucleus
0.36	GO:0016327	apicolateral plasma membrane
0.35	GO:0005737	cytoplasm

0.32

GO:0016787

sp|O95833|CLIC3_HUMAN
Chloride intracellular channel protein 3
Search

CLIC3

0.80	Chloride intracellular channel protein 3

0.77	GO:1902476	chloride transmembrane transport
0.70	GO:0034765	regulation of ion transmembrane transport
0.63	GO:0051284	positive regulation of sequestering of calcium ion
0.62	GO:0050849	negative regulation of calcium-mediated signaling
0.62	GO:0010523	negative regulation of calcium ion transport into cytosol
0.61	GO:0032410	negative regulation of transporter activity
0.60	GO:0034763	negative regulation of transmembrane transport
0.59	GO:0022898	regulation of transmembrane transporter activity
0.48	GO:0006749	glutathione metabolic process
0.46	GO:0051099	positive regulation of binding

0.77	GO:0005254	chloride channel activity
0.66	GO:0022832	voltage-gated channel activity
0.64	GO:0022839	ion gated channel activity
0.64	GO:0008381	mechanosensitive ion channel activity
0.49	GO:0004364	glutathione transferase activity
0.45	GO:0004602	glutathione peroxidase activity
0.36	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0005515	protein binding
0.34	GO:0032555	purine ribonucleotide binding

0.72	GO:0034707	chloride channel complex
0.51	GO:0016604	nuclear body
0.46	GO:0005737	cytoplasm
0.37	GO:0070062	extracellular exosome
0.36	GO:0005902	microvillus
0.36	GO:0016363	nuclear matrix
0.36	GO:0030496	midbody
0.36	GO:0045177	apical part of cell
0.35	GO:0005813	centrosome
0.35	GO:0005911	cell-cell junction

0.49

EC:2.5.1.18

GO:0004364

sp|O95834|EMAL2_HUMAN
Echinoderm microtubule-associated protein-like 2
Search

EML2

0.90	Echinoderm microtubule associated protein like 2

0.72	GO:0010968	regulation of microtubule nucleation
0.71	GO:0031115	negative regulation of microtubule polymerization
0.50	GO:0007405	neuroblast proliferation
0.50	GO:0002244	hematopoietic progenitor cell differentiation
0.49	GO:0007052	mitotic spindle organization
0.48	GO:0007420	brain development
0.39	GO:0036368	cone photoresponse recovery
0.39	GO:0007605	sensory perception of sound
0.38	GO:0007601	visual perception

0.65	GO:0008017	microtubule binding
0.42	GO:0008022	protein C-terminus binding
0.40	GO:0005102	receptor binding
0.36	GO:0005509	calcium ion binding
0.30	GO:0003824	catalytic activity

0.69	GO:0072686	mitotic spindle
0.49	GO:0051233	spindle midzone
0.48	GO:0000922	spindle pole
0.44	GO:0005829	cytosol
0.43	GO:0005874	microtubule
0.40	GO:0005875	microtubule associated complex
0.37	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O95835|LATS1_HUMAN
Serine/threonine-protein kinase LATS1
Search

LATS1

0.89	Large tumor suppressor kinase 1

0.85	GO:0035329	hippo signaling
0.75	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
0.75	GO:0000278	mitotic cell cycle
0.73	GO:0001828	inner cell mass cellular morphogenesis
0.73	GO:0001827	inner cell mass cell fate commitment
0.73	GO:0033146	regulation of intracellular estrogen receptor signaling pathway
0.72	GO:0051220	cytoplasmic sequestering of protein
0.72	GO:0090090	negative regulation of canonical Wnt signaling pathway
0.72	GO:2000058	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.72	GO:0030216	keratinocyte differentiation

0.73	GO:0030331	estrogen receptor binding
0.70	GO:0004674	protein serine/threonine kinase activity
0.65	GO:0019901	protein kinase binding
0.55	GO:0000287	magnesium ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.69	GO:0000922	spindle pole
0.43	GO:0005815	microtubule organizing center
0.41	GO:0005829	cytosol
0.39	GO:0005634	nucleus

0.70

GO:0004674

sp|O95837|GNA14_HUMAN
Guanine nucleotide-binding protein subunit alpha-14
Search

GNA14

0.83	Guanine nucleotide binding protein q polypeptide

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.52	GO:0007603	phototransduction, visible light
0.52	GO:0009649	entrainment of circadian clock
0.51	GO:0095500	acetylcholine receptor signaling pathway
0.50	GO:0045634	regulation of melanocyte differentiation
0.50	GO:0001508	action potential
0.48	GO:0048066	developmental pigmentation
0.47	GO:0001501	skeletal system development
0.46	GO:0007507	heart development
0.46	GO:0042711	maternal behavior

0.81	GO:0031683	G-protein beta/gamma-subunit complex binding
0.80	GO:0001664	G-protein coupled receptor binding
0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.64	GO:0004871	signal transducer activity
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0005096	GTPase activator activity
0.37	GO:0002046	opsin binding

0.52	GO:0001750	photoreceptor outer segment
0.49	GO:1905360	GTPase complex
0.49	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.44	GO:0030425	dendrite
0.44	GO:0044297	cell body
0.44	GO:0098797	plasma membrane protein complex
0.37	GO:0097232	lamellar body membrane
0.36	GO:0070062	extracellular exosome
0.35	GO:0031965	nuclear membrane
0.30	GO:0016021	integral component of membrane

0.35

EC:3.1.4.39

GO:0047391

sp|O95838|GLP2R_HUMAN
Glucagon-like peptide 2 receptor
Search

GLP2R

0.97	Glucagon like peptide 2 receptor

0.67	GO:0007166	cell surface receptor signaling pathway
0.67	GO:0007186	G-protein coupled receptor signaling pathway
0.48	GO:0071377	cellular response to glucagon stimulus
0.40	GO:0010906	regulation of glucose metabolic process
0.39	GO:0019933	cAMP-mediated signaling
0.38	GO:0032881	regulation of polysaccharide metabolic process
0.38	GO:0043467	regulation of generation of precursor metabolites and energy
0.38	GO:0042593	glucose homeostasis
0.37	GO:0042594	response to starvation
0.36	GO:0008284	positive regulation of cell proliferation

0.68	GO:0004930	G-protein coupled receptor activity
0.44	GO:0001653	peptide receptor activity
0.36	GO:0017046	peptide hormone binding

0.50	GO:0005886	plasma membrane
0.33	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

sp|O95841|ANGL1_HUMAN
Angiopoietin-related protein 1
Search

ANGPTL1

0.97	Angiopoietin like 1

0.71	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.55	GO:0060216	definitive hemopoiesis
0.53	GO:0045747	positive regulation of Notch signaling pathway
0.53	GO:0002244	hematopoietic progenitor cell differentiation
0.52	GO:0001525	angiogenesis

0.66

GO:0005102

receptor binding

0.69	GO:0005615	extracellular space
0.42	GO:1903561	extracellular vesicle
0.30	GO:0044425	membrane part

sp|O95843|GUC1C_HUMAN
Guanylyl cyclase-activating protein 3
Search

GUCA1C

0.92	Guanylate cyclase activating protein 4

0.85	GO:0031284	positive regulation of guanylate cyclase activity
0.69	GO:0007601	visual perception

0.86	GO:0008048	calcium sensitive guanylate cyclase activator activity
0.70	GO:0005509	calcium ion binding

0.30

GO:0044425

membrane part

sp|O95847|UCP4_HUMAN
Mitochondrial uncoupling protein 4
Search

SLC25A27

0.96	LOW QUALITY PROTEIN: mitochondrial uncoupling protein 4

0.59	GO:0006839	mitochondrial transport
0.50	GO:0051881	regulation of mitochondrial membrane potential
0.47	GO:0009409	response to cold
0.43	GO:0051562	negative regulation of mitochondrial calcium ion concentration
0.42	GO:0045837	negative regulation of membrane potential
0.42	GO:0035356	cellular triglyceride homeostasis
0.41	GO:0070997	neuron death
0.41	GO:0046324	regulation of glucose import
0.41	GO:0048839	inner ear development
0.40	GO:0008284	positive regulation of cell proliferation

0.39	GO:0022857	transmembrane transporter activity
0.34	GO:0004045	aminoacyl-tRNA hydrolase activity

0.54	GO:0031966	mitochondrial membrane
0.41	GO:0019866	organelle inner membrane
0.40	GO:0043025	neuronal cell body
0.40	GO:0045177	apical part of cell
0.30	GO:0016021	integral component of membrane

0.34

EC:3.1.1.29

GO:0004045

sp|O95848|NUD14_HUMAN
Uridine diphosphate glucose pyrophosphatase
Search

NUDT14

0.92	Uridine diphosphate glucose pyrophosphatase

0.37	GO:0007219	Notch signaling pathway
0.36	GO:0018279	protein N-linked glycosylation via asparagine
0.36	GO:0007275	multicellular organism development

0.58	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
0.53	GO:0046872	metal ion binding
0.49	GO:0042802	identical protein binding
0.38	GO:0005112	Notch binding

0.37	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.58

EC:3.6.1

GO:0016818

sp|O95857|TSN13_HUMAN
Tetraspanin-13
Search

TSPAN13

0.50	Tetraspanin

0.56	GO:1903169	regulation of calcium ion transmembrane transport
0.48	GO:0065009	regulation of molecular function
0.46	GO:0007166	cell surface receptor signaling pathway
0.34	GO:0008284	positive regulation of cell proliferation

0.58	GO:0005246	calcium channel regulator activity
0.33	GO:0005515	protein binding

0.44

GO:0005887

integral component of plasma membrane

sp|O95858|TSN15_HUMAN
Tetraspanin-15
Search

TSPAN15

0.58	Tetraspanin

0.56	GO:0072659	protein localization to plasma membrane
0.51	GO:0051604	protein maturation
0.44	GO:0007166	cell surface receptor signaling pathway
0.38	GO:0008593	regulation of Notch signaling pathway

0.50

GO:0019899

enzyme binding

0.60	GO:0097197	tetraspanin-enriched microdomain
0.52	GO:0009986	cell surface
0.42	GO:0005887	integral component of plasma membrane
0.38	GO:0031982	vesicle
0.38	GO:0043230	extracellular organelle
0.37	GO:0005615	extracellular space
0.37	GO:0098805	whole membrane
0.36	GO:0098588	bounding membrane of organelle
0.36	GO:0012505	endomembrane system
0.34	GO:0044446	intracellular organelle part

sp|O95859|TSN12_HUMAN
Tetraspanin-12
Search

TSPAN12

0.59	Tetraspanin

0.61	GO:0010842	retina layer formation
0.58	GO:0045765	regulation of angiogenesis
0.53	GO:0007166	cell surface receptor signaling pathway
0.42	GO:0001525	angiogenesis

0.43	GO:0042813	Wnt-activated receptor activity
0.33	GO:0005515	protein binding

0.50

GO:0005887

integral component of plasma membrane

sp|O95861|BPNT1_HUMAN
3'(2'),5'-bisphosphate nucleotidase 1
Search

BPNT1

0.96	3'(2'),5'-bisphosphate nucleotidase 1 isoform B

0.74	GO:0046854	phosphatidylinositol phosphorylation
0.37	GO:0016311	dephosphorylation
0.36	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
0.34	GO:0007399	nervous system development

0.41	GO:0008441	3'(2'),5'-bisphosphate nucleotidase activity
0.35	GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity
0.34	GO:0046872	metal ion binding

0.36	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.41

EC:3.1.3.7

GO:0008441

sp|O95863|SNAI1_HUMAN
Zinc finger protein SNAI1
Search

SNAI1

0.92	Snail family transcriptional repressor 1

0.73	GO:0010957	negative regulation of vitamin D biosynthetic process
0.71	GO:2000810	regulation of bicellular tight junction assembly
0.71	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
0.70	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
0.69	GO:0001837	epithelial to mesenchymal transition
0.68	GO:0001649	osteoblast differentiation
0.66	GO:0060806	negative regulation of cell differentiation involved in embryonic placenta development
0.65	GO:0030335	positive regulation of cell migration
0.65	GO:0007219	Notch signaling pathway
0.65	GO:0060536	cartilage morphogenesis

0.67	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.57	GO:0019900	kinase binding
0.56	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.41	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.40	GO:0003682	chromatin binding
0.33	GO:0046872	metal ion binding

0.61	GO:0005721	pericentric heterochromatin
0.52	GO:0005634	nucleus
0.51	GO:0005829	cytosol
0.45	GO:0070013	intracellular organelle lumen

sp|O95864|FADS2_HUMAN
Fatty acid desaturase 2
Search

FADS2

0.46	Fatty acid desaturase

0.63	GO:0006629	lipid metabolic process
0.52	GO:0055114	oxidation-reduction process
0.42	GO:0072330	monocarboxylic acid biosynthetic process
0.36	GO:0017144	drug metabolic process
0.36	GO:0006690	icosanoid metabolic process
0.35	GO:0031667	response to nutrient levels
0.35	GO:0035900	response to isolation stress
0.34	GO:0009744	response to sucrose
0.34	GO:1901570	fatty acid derivative biosynthetic process
0.34	GO:0032868	response to insulin

0.55	GO:0016215	acyl-CoA desaturase activity
0.37	GO:0045485	omega-6 fatty acid desaturase activity
0.35	GO:0102003	Delta8-sphingolipid desaturase activity
0.35	GO:0000248	C-5 sterol desaturase activity
0.32	GO:0003676	nucleic acid binding

0.40	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0005887	integral component of plasma membrane
0.33	GO:0005634	nucleus
0.32	GO:0005739	mitochondrion

0.55

EC:1.14.19

GO:0016215

sp|O95865|DDAH2_HUMAN
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
Search

DDAH2

0.88	Dimethylarginine dimethylaminohydrolase 2

0.86	GO:0000052	citrulline metabolic process
0.85	GO:0045429	positive regulation of nitric oxide biosynthetic process
0.76	GO:0006527	arginine catabolic process
0.48	GO:0043116	negative regulation of vascular permeability
0.48	GO:1900038	negative regulation of cellular response to hypoxia
0.46	GO:0003073	regulation of systemic arterial blood pressure
0.44	GO:0008285	negative regulation of cell proliferation
0.37	GO:0006809	nitric oxide biosynthetic process
0.37	GO:0007263	nitric oxide mediated signal transduction
0.37	GO:0045766	positive regulation of angiogenesis

0.85	GO:0016403	dimethylargininase activity
0.40	GO:0016597	amino acid binding
0.35	GO:0005515	protein binding
0.33	GO:0046872	metal ion binding
0.33	GO:0005254	chloride channel activity

0.52	GO:0005815	microtubule organizing center
0.49	GO:0005829	cytosol
0.41	GO:0005739	mitochondrion
0.38	GO:0070062	extracellular exosome

0.85

EC:3.5.3.18

GO:0016403

sp|O95866|G6B_HUMAN
Protein G6b
Search

MPIG6B

0.97	Megakaryocyte and platelet inhibitory receptor G6b

0.72	GO:0035855	megakaryocyte development
0.72	GO:0030220	platelet formation
0.67	GO:0030218	erythrocyte differentiation
0.66	GO:0007596	blood coagulation
0.65	GO:0007229	integrin-mediated signaling pathway
0.59	GO:0009968	negative regulation of signal transduction
0.39	GO:0001775	cell activation

0.42	GO:0008201	heparin binding
0.38	GO:0005515	protein binding

0.57	GO:0005794	Golgi apparatus
0.48	GO:0005886	plasma membrane
0.37	GO:0005783	endoplasmic reticulum
0.30	GO:0016021	integral component of membrane

sp|O95867|LY66C_HUMAN
Lymphocyte antigen 6 complex locus protein G6c
Search

LY6G6C

0.97	Lymphocyte antigen 6 family member G6C

0.77	GO:0051260	protein homooligomerization
0.43	GO:0006501	C-terminal protein lipidation

0.73

GO:0042802

identical protein binding

0.81	GO:0009897	external side of plasma membrane
0.59	GO:0043234	protein complex
0.48	GO:0031225	anchored component of membrane
0.38	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

sp|O95868|LY66D_HUMAN
Lymphocyte antigen 6 complex locus protein G6d
Search

LY6G6D

0.97	Lymphocyte antigen 6 complex G6D

0.73	GO:2000272	negative regulation of receptor activity
0.72	GO:0095500	acetylcholine receptor signaling pathway
0.67	GO:0051260	protein homooligomerization
0.49	GO:0006501	C-terminal protein lipidation

0.75	GO:0030550	acetylcholine receptor inhibitor activity
0.63	GO:0042802	identical protein binding

0.69	GO:0009897	external side of plasma membrane
0.54	GO:0031225	anchored component of membrane
0.53	GO:0030175	filopodium
0.52	GO:0043234	protein complex
0.42	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

sp|O95870|ABHGA_HUMAN
Protein ABHD16A
Search

ABHD16A

0.95	HLA-B-associated transcript 5

0.64	GO:1905344	prostaglandin catabolic process
0.63	GO:0052651	monoacylglycerol catabolic process

0.59	GO:0047372	acylglycerol lipase activity
0.37	GO:0004622	lysophospholipase activity
0.34	GO:0005515	protein binding

0.32	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.59

EC:3.1.1.23

GO:0047372

sp|O95872|GPAN1_HUMAN
G patch domain and ankyrin repeat-containing protein 1
Search

GPANK1

0.97	G patch domain and ankyrin repeats-containing protein 1

0.51	GO:0003676	nucleic acid binding
0.36	GO:0005515	protein binding

0.30

GO:0044425

membrane part

sp|O95873|CF047_HUMAN
Uncharacterized protein C6orf47
Search

0.46	Putative conserved protein with signal anchor

sp|O95876|FRITZ_HUMAN
WD repeat-containing and planar cell polarity effector protein fritz homolog
Search

WDPCP

0.97	WD repeat-containing and planar cell polarity effector protein fritz

0.87	GO:0090521	glomerular visceral epithelial cell migration
0.86	GO:0002093	auditory receptor cell morphogenesis
0.85	GO:0010762	regulation of fibroblast migration
0.85	GO:1900027	regulation of ruffle assembly
0.85	GO:0051893	regulation of focal adhesion assembly
0.85	GO:0042733	embryonic digit morphogenesis
0.84	GO:0060021	palate development
0.83	GO:0007224	smoothened signaling pathway
0.82	GO:0055123	digestive system development
0.81	GO:0060541	respiratory system development

0.38	GO:0005515	protein binding
0.36	GO:0020037	heme binding

0.87	GO:0097541	axonemal basal plate
0.48	GO:0016324	apical plasma membrane
0.46	GO:0005938	cell cortex

sp|O95881|TXD12_HUMAN
Thioredoxin domain-containing protein 12
Search

TXNDC12

0.60	Thioredoxin domain-containing protein 12

0.67	GO:0045454	cell redox homeostasis
0.58	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.45	GO:0030154	cell differentiation
0.41	GO:0055114	oxidation-reduction process
0.34	GO:0051607	defense response to virus
0.33	GO:0016032	viral process
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0008643	carbohydrate transport
0.33	GO:0051260	protein homooligomerization
0.33	GO:0006091	generation of precursor metabolites and energy

0.55	GO:0015037	peptide disulfide oxidoreductase activity
0.42	GO:0019153	protein-disulfide reductase (glutathione) activity
0.34	GO:0003924	GTPase activity
0.34	GO:0032550	purine ribonucleoside binding
0.34	GO:0019001	guanyl nucleotide binding
0.33	GO:0005351	sugar:proton symporter activity
0.33	GO:0005515	protein binding
0.33	GO:0004531	deoxyribonuclease II activity
0.33	GO:0009055	electron transfer activity
0.33	GO:0032555	purine ribonucleotide binding

0.55	GO:0005788	endoplasmic reticulum lumen
0.34	GO:1905360	GTPase complex
0.33	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.33	GO:0000139	Golgi membrane
0.33	GO:0098797	plasma membrane protein complex
0.30	GO:0016021	integral component of membrane

0.42

EC:1.8.4.2

GO:0019153

sp|O95886|DLGP3_HUMAN
Disks large-associated protein 3
Search

DLGAP3

0.95	Disks large-associated protein 3

0.60	GO:0023052	signaling
0.46	GO:0006461	protein complex assembly
0.38	GO:0007154	cell communication

0.67	GO:0001540	amyloid-beta binding
0.50	GO:0019904	protein domain specific binding
0.37	GO:0097110	scaffold protein binding
0.36	GO:0032947	protein complex scaffold activity
0.32	GO:0003676	nucleic acid binding

0.61	GO:0045202	synapse
0.40	GO:0098590	plasma membrane region
0.40	GO:0097458	neuron part
0.40	GO:0030054	cell junction
0.38	GO:0017146	NMDA selective glutamate receptor complex
0.37	GO:0044297	cell body
0.36	GO:0120038	plasma membrane bounded cell projection part
0.35	GO:0043226	organelle

sp|O95897|NOE2_HUMAN
Noelin-2
Search

OLFM2

0.97	Olfactomedin 2

0.69	GO:0051152	positive regulation of smooth muscle cell differentiation
0.67	GO:0032501	multicellular organismal process
0.63	GO:0007626	locomotory behavior
0.59	GO:0048856	anatomical structure development
0.55	GO:0009306	protein secretion
0.54	GO:0048863	stem cell differentiation
0.47	GO:1905174	regulation of vascular smooth muscle cell dedifferentiation
0.40	GO:0010718	positive regulation of epithelial to mesenchymal transition
0.38	GO:0023041	neuronal signal transduction
0.37	GO:0010628	positive regulation of gene expression

0.41	GO:0005201	extracellular matrix structural constituent
0.39	GO:0005515	protein binding

0.67	GO:0032281	AMPA glutamate receptor complex
0.61	GO:0097060	synaptic membrane
0.56	GO:0005654	nucleoplasm
0.54	GO:0005576	extracellular region
0.43	GO:0030054	cell junction
0.42	GO:0005737	cytoplasm
0.37	GO:0005581	collagen trimer
0.37	GO:0044295	axonal growth cone
0.37	GO:0043204	perikaryon
0.35	GO:0012505	endomembrane system

sp|O95900|TRUB2_HUMAN
Probable tRNA pseudouridine synthase 2
Search

TRUB2

0.89	Mitochondrial mRNA pseudouridine synthase TRUB2

0.72	GO:0001522	pseudouridine synthesis
0.63	GO:0006396	RNA processing
0.38	GO:0016071	mRNA metabolic process
0.36	GO:0006399	tRNA metabolic process

0.72	GO:0009982	pseudouridine synthase activity
0.59	GO:0003723	RNA binding

0.49	GO:0005829	cytosol
0.39	GO:0005759	mitochondrial matrix
0.34	GO:0005794	Golgi apparatus

0.72

EC:5.4.99.12

GO:0009982

sp|O95905|ECD_HUMAN
Protein ecdysoneless homolog
Search

ECD

0.95	Ecdysoneless cell cycle regulator

0.79	GO:2000045	regulation of G1/S transition of mitotic cell cycle
0.75	GO:0008283	cell proliferation
0.73	GO:0045944	positive regulation of transcription by RNA polymerase II
0.61	GO:0006366	transcription by RNA polymerase II
0.42	GO:0006110	regulation of glycolytic process
0.42	GO:0008380	RNA splicing
0.41	GO:0006397	mRNA processing

0.85	GO:0035035	histone acetyltransferase binding
0.64	GO:0003713	transcription coactivator activity
0.32	GO:0008270	zinc ion binding
0.32	GO:0003676	nucleic acid binding

0.80	GO:0097255	R2TP complex
0.68	GO:0005654	nucleoplasm
0.66	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O95907|MOT3_HUMAN
Monocarboxylate transporter 3
Search

SLC16A8

0.92	Monocarboxylate transporter 3

0.81	GO:0035873	lactate transmembrane transport
0.37	GO:0050900	leukocyte migration
0.35	GO:0006090	pyruvate metabolic process

0.81	GO:0015129	lactate transmembrane transporter activity
0.37	GO:0015293	symporter activity

0.67	GO:0005887	integral component of plasma membrane
0.34	GO:0031965	nuclear membrane

sp|O95918|OR2H2_HUMAN
Olfactory receptor 2H2
Search

0.45	Olfactory receptor

0.75	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.35	GO:0007618	mating
0.34	GO:0006952	defense response

0.76	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O95922|TTLL1_HUMAN
Probable tubulin polyglutamylase TTLL1
Search

TTLL1

0.92	Ubulin polyglutamylase TTLL1

0.85	GO:0018095	protein polyglutamylation
0.50	GO:0097724	sperm flagellum movement
0.48	GO:0060294	cilium movement involved in cell motility
0.48	GO:0007288	sperm axoneme assembly
0.48	GO:0003351	epithelial cilium movement

0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0070740	tubulin-glutamic acid ligase activity
0.34	GO:0005515	protein binding

0.40	GO:0005874	microtubule
0.35	GO:0005829	cytosol

0.43

EC:6.3.2

GO:0070740

sp|O95925|EPPI_HUMAN
Eppin
Search

0.97	WAP four-disulfide core domain protein 6

0.76	GO:0010466	negative regulation of peptidase activity
0.75	GO:0052548	regulation of endopeptidase activity
0.44	GO:0006508	proteolysis
0.41	GO:1901318	negative regulation of flagellated sperm motility
0.41	GO:0042742	defense response to bacterium
0.41	GO:0090281	negative regulation of calcium ion import
0.38	GO:0051259	protein oligomerization
0.37	GO:0019730	antimicrobial humoral response
0.36	GO:0007596	blood coagulation
0.36	GO:0006030	chitin metabolic process

0.78	GO:0004867	serine-type endopeptidase inhibitor activity
0.45	GO:0008233	peptidase activity
0.35	GO:0008061	chitin binding
0.34	GO:0005515	protein binding
0.34	GO:0090729	toxin activity

0.63	GO:0005576	extracellular region
0.51	GO:0097223	sperm part
0.49	GO:0030141	secretory granule
0.39	GO:0009986	cell surface
0.35	GO:0043234	protein complex
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.45

GO:0008233

sp|O95926|SYF2_HUMAN
Pre-mRNA-splicing factor SYF2
Search

SYF2

0.83	Pre-mRNA-splicing factor SYF2

0.74	GO:0007095	mitotic G2 DNA damage checkpoint
0.70	GO:0007369	gastrulation
0.68	GO:0001701	in utero embryonic development
0.68	GO:0048568	embryonic organ development
0.53	GO:0008380	RNA splicing
0.51	GO:0006397	mRNA processing
0.48	GO:0008284	positive regulation of cell proliferation

0.39	GO:0003723	RNA binding
0.37	GO:0005515	protein binding

0.80	GO:0071007	U2-type catalytic step 2 spliceosome
0.74	GO:0016607	nuclear speck
0.67	GO:0000974	Prp19 complex
0.65	GO:0071014	post-mRNA release spliceosomal complex

sp|O95931|CBX7_HUMAN
Chromobox protein homolog 7
Search

CBX7

0.97	Chromobox protein like protein 7

0.54	GO:0000122	negative regulation of transcription by RNA polymerase II
0.42	GO:0016574	histone ubiquitination
0.40	GO:0048733	sebaceous gland development
0.38	GO:0050790	regulation of catalytic activity
0.34	GO:0002244	hematopoietic progenitor cell differentiation
0.34	GO:0006351	transcription, DNA-templated
0.33	GO:0010714	positive regulation of collagen metabolic process
0.33	GO:0032965	regulation of collagen biosynthetic process
0.33	GO:0045739	positive regulation of DNA repair
0.33	GO:0070301	cellular response to hydrogen peroxide

0.44	GO:0140034	methylation-dependent protein binding
0.43	GO:0003727	single-stranded RNA binding
0.43	GO:0042393	histone binding
0.42	GO:0097027	ubiquitin-protein transferase activator activity
0.38	GO:0003682	chromatin binding
0.32	GO:0003677	DNA binding

0.61	GO:0005634	nucleus
0.52	GO:0000785	chromatin
0.49	GO:0031974	membrane-enclosed lumen
0.48	GO:0005829	cytosol
0.45	GO:0043234	protein complex
0.43	GO:0000151	ubiquitin ligase complex
0.30	GO:0031224	intrinsic component of membrane

sp|O95932|TGM3L_HUMAN
Protein-glutamine gamma-glutamyltransferase 6
Search

TGM6

0.97	Transglutaminase y

0.84	GO:0018149	peptide cross-linking
0.48	GO:0030216	keratinocyte differentiation
0.46	GO:0051262	protein tetramerization
0.45	GO:0043163	cell envelope organization
0.34	GO:0031069	hair follicle morphogenesis
0.34	GO:0035315	hair cell differentiation

0.84	GO:0003810	protein-glutamine gamma-glutamyltransferase activity
0.43	GO:0005509	calcium ion binding

0.46	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.41	GO:0005737	cytoplasm
0.35	GO:0070062	extracellular exosome
0.34	GO:0001533	cornified envelope

0.84

EC:2.3.2.13

GO:0003810

sp|O95935|TBX18_HUMAN
T-box transcription factor TBX18
Search

TBX18

0.89	T-box transcription factor TBX18

0.57	GO:0006351	transcription, DNA-templated
0.57	GO:0072001	renal system development
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.46	GO:0048562	embryonic organ morphogenesis
0.45	GO:0043009	chordate embryonic development
0.45	GO:1904888	cranial skeletal system development
0.44	GO:0048705	skeletal system morphogenesis
0.43	GO:0051253	negative regulation of RNA metabolic process

0.61	GO:0003700	DNA binding transcription factor activity
0.54	GO:0003677	DNA binding
0.48	GO:0001106	RNA polymerase II transcription corepressor activity
0.45	GO:0001067	regulatory region nucleic acid binding
0.45	GO:0042803	protein homodimerization activity
0.44	GO:0046982	protein heterodimerization activity
0.37	GO:0001085	RNA polymerase II transcription factor binding

0.61	GO:0005634	nucleus
0.46	GO:0017053	transcriptional repressor complex
0.41	GO:0031974	membrane-enclosed lumen
0.39	GO:0044446	intracellular organelle part

sp|O95936|EOMES_HUMAN
Eomesodermin homolog
Search

EOMES

0.95	T-box brain protein 1

0.64	GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response
0.58	GO:0007420	brain development
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.55	GO:0051254	positive regulation of RNA metabolic process
0.54	GO:0010557	positive regulation of macromolecule biosynthetic process
0.54	GO:0031328	positive regulation of cellular biosynthetic process
0.52	GO:0001714	endodermal cell fate specification

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.49	GO:0001067	regulatory region nucleic acid binding
0.48	GO:0001102	RNA polymerase II activating transcription factor binding
0.48	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding
0.45	GO:0003682	chromatin binding
0.35	GO:0019901	protein kinase binding
0.34	GO:0005452	inorganic anion exchanger activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding

0.61	GO:0005634	nucleus
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|O95944|NCTR2_HUMAN
Natural cytotoxicity triggering receptor 2
Search

NCR2

0.97	Triggering receptor expressed on myeloid cells like 4

0.53	GO:0006968	cellular defense response
0.48	GO:0045087	innate immune response
0.47	GO:0050776	regulation of immune response
0.41	GO:0007165	signal transduction
0.39	GO:0031349	positive regulation of defense response
0.38	GO:0009967	positive regulation of signal transduction
0.38	GO:0002684	positive regulation of immune system process

0.45	GO:0099600	transmembrane receptor activity
0.43	GO:0038023	signaling receptor activity
0.42	GO:0005515	protein binding

0.44

GO:0005887

integral component of plasma membrane

sp|O95947|TBX6_HUMAN
T-box transcription factor TBX6
Search

TBX6

0.93	T-box transcription factor TBX6

0.64	GO:0014043	negative regulation of neuron maturation
0.63	GO:0032525	somite rostral/caudal axis specification
0.62	GO:0023019	signal transduction involved in regulation of gene expression
0.60	GO:0001707	mesoderm formation
0.59	GO:0010977	negative regulation of neuron projection development
0.59	GO:0001708	cell fate specification
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:0051254	positive regulation of RNA metabolic process

0.61	GO:0003700	DNA binding transcription factor activity
0.60	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding
0.60	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.60	GO:0001102	RNA polymerase II activating transcription factor binding
0.35	GO:0003714	transcription corepressor activity
0.35	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0001104	RNA polymerase II transcription cofactor activity
0.35	GO:0042803	protein homodimerization activity
0.35	GO:0046982	protein heterodimerization activity
0.34	GO:0005249	voltage-gated potassium channel activity

0.61	GO:0005634	nucleus
0.35	GO:0017053	transcriptional repressor complex
0.33	GO:0070013	intracellular organelle lumen
0.33	GO:0044446	intracellular organelle part
0.33	GO:0005667	transcription factor complex
0.33	GO:0032993	protein-DNA complex
0.33	GO:0005694	chromosome
0.33	GO:0015629	actin cytoskeleton
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|O95948|ONEC2_HUMAN
One cut domain family member 2
Search

ONECUT2

0.80	One cut domain family member

0.64	GO:0001889	liver development
0.62	GO:0031018	endocrine pancreas development
0.61	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.61	GO:0001952	regulation of cell-matrix adhesion
0.59	GO:0002064	epithelial cell development
0.59	GO:0030335	positive regulation of cell migration
0.59	GO:0045165	cell fate commitment
0.59	GO:0006366	transcription by RNA polymerase II
0.58	GO:0045944	positive regulation of transcription by RNA polymerase II
0.58	GO:0060271	cilium assembly

0.62	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.58	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.54	GO:0003677	DNA binding
0.52	GO:0001067	regulatory region nucleic acid binding

0.61	GO:0005634	nucleus
0.51	GO:0015629	actin cytoskeleton
0.48	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.36	GO:0005667	transcription factor complex

sp|O95954|FTCD_HUMAN
Formimidoyltransferase-cyclodeaminase
Search

FTCD

0.80	Formimidoyltransferase-cyclodeaminase

0.39	GO:0019557	histidine catabolic process to glutamate and formate
0.39	GO:0043606	formamide metabolic process
0.39	GO:0035999	tetrahydrofolate interconversion
0.36	GO:0007010	cytoskeleton organization
0.33	GO:0006352	DNA-templated transcription, initiation
0.33	GO:0015074	DNA integration
0.33	GO:0006310	DNA recombination

0.84	GO:0005542	folic acid binding
0.51	GO:0016740	transferase activity
0.50	GO:0008017	microtubule binding
0.42	GO:0030412	formimidoyltetrahydrofolate cyclodeaminase activity
0.35	GO:0019215	intermediate filament binding
0.33	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity
0.33	GO:0016866	intramolecular transferase activity
0.32	GO:0003677	DNA binding

0.59	GO:0030868	smooth endoplasmic reticulum membrane
0.52	GO:0005794	Golgi apparatus
0.48	GO:0005829	cytosol
0.42	GO:0005886	plasma membrane
0.40	GO:0005814	centriole
0.38	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.37	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.51	EC:2	GO:0016740
0.42	KEGG:R02302	GO:0030412

sp|O95965|ITGBL_HUMAN
Integrin beta-like protein 1
Search

ITGBL1

0.83	Integrin subunit beta like 1

0.72	GO:0007229	integrin-mediated signaling pathway
0.53	GO:0060055	angiogenesis involved in wound healing
0.53	GO:0070527	platelet aggregation
0.52	GO:0007044	cell-substrate junction assembly
0.50	GO:0007160	cell-matrix adhesion
0.49	GO:0030334	regulation of cell migration
0.42	GO:0033690	positive regulation of osteoblast proliferation
0.42	GO:0036120	cellular response to platelet-derived growth factor stimulus
0.41	GO:0043277	apoptotic cell clearance
0.41	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading

0.44	GO:0004872	receptor activity
0.41	GO:0005178	integrin binding
0.41	GO:0005080	protein kinase C binding
0.34	GO:0038132	neuregulin binding
0.34	GO:0043184	vascular endothelial growth factor receptor 2 binding
0.34	GO:0019960	C-X3-C chemokine binding
0.34	GO:0042802	identical protein binding
0.34	GO:0005509	calcium ion binding
0.34	GO:0031994	insulin-like growth factor I binding
0.34	GO:0001618	virus receptor activity

0.51	GO:0005615	extracellular space
0.50	GO:0008305	integrin complex
0.43	GO:0035866	alphav-beta3 integrin-PKCalpha complex
0.42	GO:0071133	alpha9-beta1 integrin-ADAM8 complex
0.40	GO:0009897	external side of plasma membrane
0.40	GO:0016324	apical plasma membrane
0.34	GO:0071062	alphav-beta3 integrin-vitronectin complex
0.34	GO:0035868	alphav-beta3 integrin-HMGB1 complex
0.34	GO:0031092	platelet alpha granule membrane
0.34	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex

0.33

EC:5.3.4.1

GO:0003756

sp|O95967|FBLN4_HUMAN
EGF-containing fibulin-like extracellular matrix protein 2
Search

EFEMP2

0.97	EGF containing fibulin like extracellular matrix protein 2

0.84	GO:0048251	elastic fiber assembly
0.54	GO:0007173	epidermal growth factor receptor signaling pathway
0.40	GO:0048050	post-embryonic eye morphogenesis
0.39	GO:0032331	negative regulation of chondrocyte differentiation
0.39	GO:0048048	embryonic eye morphogenesis
0.38	GO:0043010	camera-type eye development
0.38	GO:0018108	peptidyl-tyrosine phosphorylation
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:0010468	regulation of gene expression

0.70	GO:0005509	calcium ion binding
0.56	GO:0005006	epidermal growth factor-activated receptor activity
0.39	GO:0005154	epidermal growth factor receptor binding
0.36	GO:0017134	fibroblast growth factor binding
0.35	GO:0005201	extracellular matrix structural constituent
0.32	GO:0003700	DNA binding transcription factor activity
0.32	GO:0003677	DNA binding

0.71	GO:0044421	extracellular region part
0.37	GO:0031982	vesicle
0.30	GO:0016020	membrane

sp|O95968|SG1D1_HUMAN
Secretoglobin family 1D member 1
Search

0.97	Pheromaxein A subunit

0.53	GO:0007165	signal transduction
0.41	GO:0000770	peptide pheromone export
0.38	GO:0032696	negative regulation of interleukin-13 production
0.38	GO:0032714	negative regulation of interleukin-5 production
0.38	GO:0032713	negative regulation of interleukin-4 production
0.38	GO:0032689	negative regulation of interferon-gamma production
0.37	GO:0042130	negative regulation of T cell proliferation
0.37	GO:0043488	regulation of mRNA stability
0.37	GO:0050727	regulation of inflammatory response
0.36	GO:0000122	negative regulation of transcription by RNA polymerase II

0.55	GO:0046982	protein heterodimerization activity
0.41	GO:0005550	pheromone binding

0.56	GO:0005615	extracellular space
0.33	GO:0005737	cytoplasm

sp|O95969|SG1D2_HUMAN
Secretoglobin family 1D member 2
Search

0.97	Pheromaxein A subunit

0.55	GO:0007165	signal transduction
0.45	GO:0032696	negative regulation of interleukin-13 production
0.45	GO:0032714	negative regulation of interleukin-5 production
0.45	GO:0032713	negative regulation of interleukin-4 production
0.44	GO:0032689	negative regulation of interferon-gamma production
0.44	GO:0042130	negative regulation of T cell proliferation
0.43	GO:0043488	regulation of mRNA stability
0.43	GO:0050727	regulation of inflammatory response
0.42	GO:0034021	response to silicon dioxide
0.42	GO:0000122	negative regulation of transcription by RNA polymerase II

0.49	GO:0046982	protein heterodimerization activity
0.42	GO:0097160	polychlorinated biphenyl binding
0.40	GO:0005550	pheromone binding
0.38	GO:0019834	phospholipase A2 inhibitor activity

0.55	GO:0005615	extracellular space
0.39	GO:0005791	rough endoplasmic reticulum
0.39	GO:0030141	secretory granule
0.38	GO:0005635	nuclear envelope
0.36	GO:1903561	extracellular vesicle

sp|O95970|LGI1_HUMAN
Leucine-rich glioma-inactivated protein 1
Search

LGI1

0.97	Leucine-rich glioma-inactivated protein 1

0.72	GO:0030307	positive regulation of cell growth
0.71	GO:0007399	nervous system development
0.69	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.68	GO:0000904	cell morphogenesis involved in differentiation
0.66	GO:0120036	plasma membrane bounded cell projection organization
0.62	GO:0006935	chemotaxis
0.61	GO:0006928	movement of cell or subcellular component
0.54	GO:0060322	head development
0.51	GO:0048513	animal organ development
0.50	GO:0050806	positive regulation of synaptic transmission

0.63	GO:0005102	receptor binding
0.39	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.34	GO:0046872	metal ion binding

0.66	GO:0005615	extracellular space
0.47	GO:0045202	synapse
0.45	GO:0030054	cell junction
0.30	GO:0016020	membrane

0.39

GO:0004114

sp|O95971|BY55_HUMAN
CD160 antigen
Search

sp|O95972|BMP15_HUMAN
Bone morphogenetic protein 15
Search

BMP15

0.96	Bone morphogenetic protein 15

0.86	GO:0060016	granulosa cell development
0.84	GO:0001541	ovarian follicle development
0.74	GO:0010469	regulation of receptor activity
0.51	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.50	GO:0060395	SMAD protein signal transduction
0.50	GO:0030509	BMP signaling pathway
0.47	GO:0043408	regulation of MAPK cascade
0.46	GO:0042981	regulation of apoptotic process
0.42	GO:0007292	female gamete generation
0.41	GO:0060283	negative regulation of oocyte development

0.77	GO:0008083	growth factor activity
0.50	GO:0005160	transforming growth factor beta receptor binding
0.49	GO:0005125	cytokine activity

0.72	GO:0005615	extracellular space
0.39	GO:0005737	cytoplasm
0.35	GO:0012505	endomembrane system
0.35	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part
0.34	GO:0043227	membrane-bounded organelle
0.30	GO:0016020	membrane

sp|O95976|IGSF6_HUMAN
Immunoglobulin superfamily member 6
Search

IGSF6

0.97	Immunoglobulin superfamily member 6

0.39	GO:0006955	immune response
0.39	GO:0007166	cell surface receptor signaling pathway

0.39	GO:0099600	transmembrane receptor activity
0.38	GO:0038023	signaling receptor activity

0.38

GO:0005887

integral component of plasma membrane

sp|O95977|S1PR4_HUMAN
Sphingosine 1-phosphate receptor 4
Search

S1PR4

0.93	Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 6 (Predicted)

0.81	GO:0003376	sphingosine-1-phosphate signaling pathway
0.58	GO:0038171	cannabinoid signaling pathway
0.57	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
0.54	GO:0019933	cAMP-mediated signaling
0.46	GO:0030595	leukocyte chemotaxis
0.44	GO:1990266	neutrophil migration
0.41	GO:0003245	cardiac muscle tissue growth involved in heart morphogenesis
0.41	GO:0007399	nervous system development
0.41	GO:0120036	plasma membrane bounded cell projection organization
0.41	GO:2000026	regulation of multicellular organismal development

0.81	GO:0038036	sphingosine-1-phosphate receptor activity
0.58	GO:0004949	cannabinoid receptor activity
0.39	GO:0005102	receptor binding
0.37	GO:0050839	cell adhesion molecule binding
0.37	GO:0032403	protein complex binding
0.35	GO:0008289	lipid binding
0.35	GO:0070915	lysophosphatidic acid receptor activity
0.33	GO:0004952	dopamine neurotransmitter receptor activity
0.33	GO:0003924	GTPase activity
0.33	GO:0005525	GTP binding

0.44	GO:0005739	mitochondrion
0.39	GO:0005886	plasma membrane
0.38	GO:0009986	cell surface
0.38	GO:0098552	side of membrane
0.38	GO:0030426	growth cone
0.37	GO:0030424	axon
0.37	GO:0098793	presynapse
0.37	GO:0005654	nucleoplasm
0.33	GO:0098857	membrane microdomain
0.33	GO:0031968	organelle outer membrane

sp|O95980|RECK_HUMAN
Reversion-inducing cysteine-rich protein with Kazal motifs
Search

RECK

0.87	Reversion inducing cysteine rich protein with kazal motifs

0.65	GO:0030336	negative regulation of cell migration
0.60	GO:0010951	negative regulation of endopeptidase activity
0.39	GO:1990791	dorsal root ganglion development
0.38	GO:0090049	regulation of cell migration involved in sprouting angiogenesis
0.38	GO:0002040	sprouting angiogenesis
0.38	GO:0060828	regulation of canonical Wnt signaling pathway
0.37	GO:0016055	Wnt signaling pathway
0.30	GO:0044238	primary metabolic process
0.30	GO:1901566	organonitrogen compound biosynthetic process
0.30	GO:0043412	macromolecule modification

0.61	GO:0004866	endopeptidase inhibitor activity
0.30	GO:0005515	protein binding

0.47	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane
0.30	GO:0005576	extracellular region
0.30	GO:0031225	anchored component of membrane

sp|O95983|MBD3_HUMAN
Methyl-CpG-binding domain protein 3
Search

MBD3

0.95	Methyl-CpG-binding domain protein 3

0.58	GO:0006346	methylation-dependent chromatin silencing
0.52	GO:0000122	negative regulation of transcription by RNA polymerase II
0.51	GO:0001701	in utero embryonic development
0.51	GO:0016573	histone acetylation
0.50	GO:0009888	tissue development
0.40	GO:0060216	definitive hemopoiesis
0.40	GO:0002244	hematopoietic progenitor cell differentiation
0.39	GO:0044030	regulation of DNA methylation
0.39	GO:0032355	response to estradiol
0.38	GO:0007568	aging

0.84	GO:0008327	methyl-CpG binding
0.50	GO:0003682	chromatin binding
0.37	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.36	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0044877	macromolecular complex binding
0.35	GO:0004407	histone deacetylase activity
0.34	GO:0005515	protein binding
0.34	GO:0008121	ubiquinol-cytochrome-c reductase activity

0.83	GO:0016581	NuRD complex
0.53	GO:0000792	heterochromatin
0.43	GO:0043234	protein complex
0.38	GO:0005737	cytoplasm
0.35	GO:0005730	nucleolus
0.30	GO:0016020	membrane

0.35

EC:3.5.1.98

GO:0004407

sp|O95985|TOP3B_HUMAN
DNA topoisomerase 3-beta-1
Search

TOP3B

0.55	DNA topoisomerase

0.72	GO:0006265	DNA topological change
0.49	GO:0007059	chromosome segregation
0.34	GO:0006470	protein dephosphorylation

0.77	GO:0003917	DNA topoisomerase type I activity
0.55	GO:0003677	DNA binding
0.34	GO:0003723	RNA binding
0.34	GO:0004721	phosphoprotein phosphatase activity
0.33	GO:0005515	protein binding
0.32	GO:0046872	metal ion binding

0.50	GO:0000793	condensed chromosome
0.40	GO:0005634	nucleus

0.77

EC:5.99.1.2

GO:0003917

sp|O95988|TCL1B_HUMAN
T-cell leukemia/lymphoma protein 1B
Search

TCL1B

0.97	T-cell leukemia/lymphoma protein 1B

0.85	GO:0033138	positive regulation of peptidyl-serine phosphorylation
0.80	GO:0071902	positive regulation of protein serine/threonine kinase activity

0.85	GO:0043539	protein serine/threonine kinase activator activity
0.78	GO:0019901	protein kinase binding

0.60

GO:0043234

protein complex

sp|O95989|NUDT3_HUMAN
Diphosphoinositol polyphosphate phosphohydrolase 1
Search

NUDT3

0.92	Diphosphoinositol polyphosphate phosphohydrolase

0.61	GO:0071543	diphosphoinositol polyphosphate metabolic process
0.53	GO:1901909	diadenosine hexaphosphate catabolic process
0.53	GO:1901907	diadenosine pentaphosphate catabolic process
0.53	GO:1901910	adenosine 5'-(hexahydrogen pentaphosphate) metabolic process
0.52	GO:0071545	inositol phosphate catabolic process
0.51	GO:0009169	purine ribonucleoside monophosphate catabolic process
0.49	GO:0009154	purine ribonucleotide catabolic process
0.34	GO:0007267	cell-cell signaling
0.33	GO:0000028	ribosomal small subunit assembly

0.61	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity
0.53	GO:0034431	bis(5'-adenosyl)-hexaphosphatase activity
0.52	GO:0034432	bis(5'-adenosyl)-pentaphosphatase activity
0.52	GO:0050072	m7G(5')pppN diphosphatase activity
0.51	GO:0000298	endopolyphosphatase activity
0.46	GO:0000287	magnesium ion binding
0.41	GO:0052848	inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
0.41	GO:0052844	inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
0.41	GO:0052845	inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
0.41	GO:0052846	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity

0.48	GO:0005829	cytosol
0.41	GO:0005634	nucleus
0.36	GO:0070062	extracellular exosome
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.34	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0099512	supramolecular fiber
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.61	EC:3.6.1.52	GO:0008486
0.61	KEGG:R05777	GO:0008486

sp|O95990|F107A_HUMAN
Protein FAM107A
Search

0.72	GO:0001558	regulation of cell growth
0.44	GO:0006635	fatty acid beta-oxidation
0.35	GO:0016192	vesicle-mediated transport
0.33	GO:0016310	phosphorylation

0.46	GO:0003997	acyl-CoA oxidase activity
0.44	GO:0033791	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity
0.41	GO:0050660	flavin adenine dinucleotide binding
0.38	GO:0003924	GTPase activity
0.37	GO:0032550	purine ribonucleoside binding
0.37	GO:0019001	guanyl nucleotide binding
0.36	GO:0005515	protein binding
0.35	GO:0032555	purine ribonucleotide binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0016301	kinase activity

0.73	GO:0016607	nuclear speck
0.70	GO:0043005	neuron projection
0.44	GO:0005777	peroxisome
0.30	GO:0016020	membrane

0.46

EC:1.3.3.6

GO:0003997

sp|O95992|CH25H_HUMAN
Cholesterol 25-hydroxylase
Search

CH25H

0.97	Cholesterol 25-hydroxylase

0.64	GO:0008610	lipid biosynthetic process
0.61	GO:0035754	B cell chemotaxis
0.57	GO:0008203	cholesterol metabolic process
0.52	GO:0055114	oxidation-reduction process
0.39	GO:1901617	organic hydroxy compound biosynthetic process
0.36	GO:0008206	bile acid metabolic process
0.35	GO:1901362	organic cyclic compound biosynthetic process
0.34	GO:0072330	monocarboxylic acid biosynthetic process

0.63	GO:0001567	cholesterol 25-hydroxylase activity
0.62	GO:0005506	iron ion binding

0.43	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.63	EC:1.14.99.38	GO:0001567
0.63	KEGG:R07218	GO:0001567

sp|O95994|AGR2_HUMAN
Anterior gradient protein 2 homolog
Search

AGR2

0.59	Anterior gradient protein 2

0.78	GO:0070254	mucus secretion
0.77	GO:0060480	lung goblet cell differentiation
0.76	GO:1903896	positive regulation of IRE1-mediated unfolded protein response
0.75	GO:1903899	positive regulation of PERK-mediated unfolded protein response
0.72	GO:0048565	digestive tract development
0.72	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
0.70	GO:0010811	positive regulation of cell-substrate adhesion
0.70	GO:1903078	positive regulation of protein localization to plasma membrane
0.69	GO:0048639	positive regulation of developmental growth
0.68	GO:0060548	negative regulation of cell death

0.81	GO:0002162	dystroglycan binding
0.71	GO:0005154	epidermal growth factor receptor binding
0.63	GO:0042803	protein homodimerization activity

0.66	GO:0005783	endoplasmic reticulum
0.61	GO:0005615	extracellular space
0.53	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

sp|O95995|GAS8_HUMAN
Growth arrest-specific protein 8
Search

GAS8

0.94	Growth arrest-specific protein 8

0.71	GO:0048870	cell motility
0.54	GO:0003341	cilium movement
0.50	GO:1904526	regulation of microtubule binding
0.47	GO:0035082	axoneme assembly
0.47	GO:0007368	determination of left/right symmetry
0.46	GO:0034613	cellular protein localization
0.46	GO:0007420	brain development
0.37	GO:0045880	positive regulation of smoothened signaling pathway
0.37	GO:0055001	muscle cell development
0.35	GO:0008285	negative regulation of cell proliferation

0.52	GO:0017137	Rab GTPase binding
0.44	GO:0008017	microtubule binding

0.80	GO:0031514	motile cilium
0.54	GO:0005930	axoneme
0.52	GO:0005874	microtubule
0.48	GO:0005794	Golgi apparatus
0.47	GO:0036064	ciliary basal body
0.47	GO:0097223	sperm part

sp|O95996|APCL_HUMAN
Adenomatous polyposis coli protein 2
Search

APC2

0.88	APC2, WNT signaling pathway regulator

0.83	GO:0030178	negative regulation of Wnt signaling pathway
0.80	GO:0060828	regulation of canonical Wnt signaling pathway
0.77	GO:0016055	Wnt signaling pathway
0.76	GO:0035414	negative regulation of catenin import into nucleus
0.71	GO:0090630	activation of GTPase activity
0.65	GO:0000226	microtubule cytoskeleton organization
0.47	GO:0007026	negative regulation of microtubule depolymerization
0.46	GO:0007050	cell cycle arrest
0.45	GO:0000281	mitotic cytokinesis
0.44	GO:0008285	negative regulation of cell proliferation

0.84	GO:0008013	beta-catenin binding
0.74	GO:0008017	microtubule binding
0.37	GO:0045295	gamma-catenin binding
0.36	GO:0070840	dynein complex binding
0.35	GO:0031625	ubiquitin protein ligase binding
0.35	GO:0019887	protein kinase regulator activity
0.35	GO:0019901	protein kinase binding
0.35	GO:0042802	identical protein binding

0.75	GO:0031258	lamellipodium membrane
0.74	GO:0016342	catenin complex
0.73	GO:0031941	filamentous actin
0.70	GO:0005881	cytoplasmic microtubule
0.70	GO:0045171	intercellular bridge
0.68	GO:0030496	midbody
0.67	GO:0048471	perinuclear region of cytoplasm
0.61	GO:0005794	Golgi apparatus
0.58	GO:0005829	cytosol
0.39	GO:0005634	nucleus

sp|O95997|PTTG1_HUMAN
Securin
Search

PTTG1

0.97	Pituitary tumor-transforming 1

0.66	GO:0051276	chromosome organization
0.59	GO:0045143	homologous chromosome segregation
0.55	GO:0010466	negative regulation of peptidase activity
0.52	GO:2000816	negative regulation of mitotic sister chromatid separation
0.49	GO:0140014	mitotic nuclear division
0.49	GO:0052548	regulation of endopeptidase activity
0.44	GO:0006366	transcription by RNA polymerase II
0.43	GO:0006355	regulation of transcription, DNA-templated
0.40	GO:0051301	cell division
0.40	GO:0006281	DNA repair

0.55	GO:0030414	peptidase inhibitor activity
0.49	GO:0061135	endopeptidase regulator activity
0.47	GO:0017124	SH3 domain binding
0.43	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.37	GO:0031072	heat shock protein binding
0.36	GO:0043022	ribosome binding

0.61	GO:0005634	nucleus
0.49	GO:0005737	cytoplasm

sp|O95998|I18BP_HUMAN
Interleukin-18-binding protein
Search

IL18BP

0.87	Interleukin-18-binding protein isoform c

0.84	GO:0042088	T-helper 1 type immune response
0.64	GO:1900116	extracellular negative regulation of signal transduction
0.54	GO:0070301	cellular response to hydrogen peroxide
0.54	GO:0071356	cellular response to tumor necrosis factor
0.53	GO:0032496	response to lipopolysaccharide
0.44	GO:0035655	interleukin-18-mediated signaling pathway

0.87	GO:0042007	interleukin-18 binding
0.64	GO:0048019	receptor antagonist activity

0.58	GO:0005615	extracellular space
0.47	GO:1903561	extracellular vesicle
0.30	GO:0016020	membrane

sp|O95999|BCL10_HUMAN
B-cell lymphoma/leukemia 10
Search

BCL10

0.97	Putative caspase activation and recruitment domain of b-cell lymphoma 10

0.84	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.78	GO:0006915	apoptotic process
0.74	GO:0042981	regulation of apoptotic process
0.66	GO:0045416	positive regulation of interleukin-8 biosynthetic process
0.65	GO:0006968	cellular defense response
0.65	GO:0032094	response to food
0.63	GO:0050856	regulation of T cell receptor signaling pathway
0.63	GO:0050852	T cell receptor signaling pathway
0.63	GO:0071260	cellular response to mechanical stimulus
0.62	GO:0001843	neural tube closure

0.66	GO:0043422	protein kinase B binding
0.64	GO:0051059	NF-kappaB binding
0.62	GO:0043621	protein self-association
0.62	GO:0002020	protease binding
0.61	GO:0008022	protein C-terminus binding
0.61	GO:0019209	kinase activator activity
0.59	GO:0031625	ubiquitin protein ligase binding
0.59	GO:0003713	transcription coactivator activity
0.55	GO:0042802	identical protein binding
0.37	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process

0.68	GO:0032449	CBM complex
0.64	GO:0042101	T cell receptor complex
0.63	GO:0001772	immunological synapse
0.63	GO:0046696	lipopolysaccharide receptor complex
0.61	GO:0005881	cytoplasmic microtubule
0.59	GO:0045121	membrane raft
0.59	GO:0048471	perinuclear region of cytoplasm
0.58	GO:0005764	lysosome
0.53	GO:0005829	cytosol
0.48	GO:0005634	nucleus

sp|O96000|NDUBA_HUMAN
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Search

NDUFB10

0.42	NADH-ubiquinone oxidoreductase PDSW subunit

0.79	GO:0032981	mitochondrial respiratory chain complex I assembly
0.41	GO:0055114	oxidation-reduction process
0.36	GO:0006119	oxidative phosphorylation

0.39	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.36	GO:0005515	protein binding

0.80	GO:0005747	mitochondrial respiratory chain complex I
0.43	GO:0070062	extracellular exosome

0.39

GO:0008137

sp|O96001|PPR17_HUMAN
Protein phosphatase 1 regulatory subunit 17
Search

0.62	Protein phosphatase 1 regulatory subunit 17

0.83	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.30	GO:0051716	cellular response to stimulus
0.30	GO:0007399	nervous system development
0.30	GO:0023052	signaling
0.30	GO:0007154	cell communication

0.83

GO:0004864

protein phosphatase inhibitor activity

0.47

GO:0005654

nucleoplasm

sp|O96002|TM257_HUMAN
Transmembrane protein 257
Search

TMEM257

0.97	LOW QUALITY PROTEIN: transmembrane protein 257

0.30

GO:0044425

membrane part

sp|O96004|HAND1_HUMAN
Heart- and neural crest derivatives-expressed protein 1
Search

HAND1

0.97	Heart and neural crest derivatives expressed transcript 1

0.68	GO:0003219	cardiac right ventricle formation
0.65	GO:0060536	cartilage morphogenesis
0.64	GO:2000677	regulation of transcription regulatory region DNA binding
0.64	GO:0043392	negative regulation of DNA binding
0.63	GO:0003218	cardiac left ventricle formation
0.63	GO:0001947	heart looping
0.63	GO:0003144	embryonic heart tube formation
0.62	GO:0042475	odontogenesis of dentin-containing tooth
0.62	GO:0043433	negative regulation of DNA binding transcription factor activity
0.61	GO:0060485	mesenchyme development

0.67	GO:0046983	protein dimerization activity
0.61	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.61	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.60	GO:0043425	bHLH transcription factor binding
0.57	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.56	GO:0003713	transcription coactivator activity
0.56	GO:0042802	identical protein binding
0.51	GO:0019899	enzyme binding
0.49	GO:0003680	AT DNA binding
0.47	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding

0.57	GO:0005667	transcription factor complex
0.53	GO:0031981	nuclear lumen
0.48	GO:0043232	intracellular non-membrane-bounded organelle
0.40	GO:0005737	cytoplasm

sp|O96005|CLPT1_HUMAN
Cleft lip and palate transmembrane protein 1
Search

CLPTM1

0.94	CLPTM1, transmembrane protein

0.74

GO:0033081

regulation of T cell differentiation in thymus

0.69	GO:0009897	external side of plasma membrane
0.46	GO:0005887	integral component of plasma membrane

sp|O96006|ZBED1_HUMAN
Zinc finger BED domain-containing protein 1
Search

ZBED1

0.93	Zinc finger BED domain-containing protein 1

0.54	GO:0006366	transcription by RNA polymerase II
0.53	GO:0045944	positive regulation of transcription by RNA polymerase II
0.37	GO:0016925	protein sumoylation

0.68	GO:0046983	protein dimerization activity
0.57	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.56	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.53	GO:0042802	identical protein binding
0.37	GO:0019789	SUMO transferase activity
0.35	GO:0004803	transposase activity
0.33	GO:0046872	metal ion binding

0.39	GO:0005634	nucleus
0.35	GO:0005694	chromosome
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part

sp|O96007|MOC2B_HUMAN
Molybdopterin synthase catalytic subunit
Search

MOCS2

0.61	Molybdopterin synthase catalytic subunit

0.72	GO:0006777	Mo-molybdopterin cofactor biosynthetic process
0.46	GO:0032324	molybdopterin cofactor biosynthetic process
0.39	GO:0016573	histone acetylation
0.39	GO:0006338	chromatin remodeling
0.33	GO:0006413	translational initiation

0.82	GO:0030366	molybdopterin synthase activity
0.40	GO:0004402	histone acetyltransferase activity
0.36	GO:0042802	identical protein binding
0.33	GO:0003743	translation initiation factor activity
0.32	GO:1901265	nucleoside phosphate binding
0.31	GO:0036094	small molecule binding

0.75	GO:0019008	molybdopterin synthase complex
0.66	GO:0005829	cytosol
0.53	GO:0016607	nuclear speck
0.41	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
0.40	GO:0005700	polytene chromosome
0.35	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.82

EC:2.8.1.12

GO:0030366

sp|O96008|TOM40_HUMAN
Mitochondrial import receptor subunit TOM40 homolog
Search

TOMM40

0.89	Translocase of outer mitochondrial membrane 40

0.82	GO:0030150	protein import into mitochondrial matrix
0.36	GO:0006811	ion transport
0.35	GO:0051204	protein insertion into mitochondrial membrane
0.35	GO:0016236	macroautophagy
0.35	GO:0043065	positive regulation of apoptotic process

0.74	GO:0008320	protein transmembrane transporter activity
0.40	GO:0070678	preprotein binding
0.40	GO:0015288	porin activity
0.37	GO:0030943	mitochondrion targeting sequence binding
0.34	GO:0005261	cation channel activity

0.78	GO:0005741	mitochondrial outer membrane
0.52	GO:0098798	mitochondrial protein complex
0.51	GO:0044455	mitochondrial membrane part
0.47	GO:0031301	integral component of organelle membrane
0.46	GO:0098796	membrane protein complex
0.46	GO:0005829	cytosol
0.43	GO:0019866	organelle inner membrane
0.37	GO:0070062	extracellular exosome

sp|O96009|NAPSA_HUMAN
Napsin-A
Search

NAPSA

0.83	Napsin A aspartic peptidase

0.61	GO:0006508	proteolysis
0.53	GO:0043129	surfactant homeostasis
0.45	GO:0006914	autophagy
0.44	GO:0030163	protein catabolic process
0.39	GO:0006629	lipid metabolic process
0.37	GO:0032258	protein localization by the Cvt pathway
0.36	GO:0051604	protein maturation
0.36	GO:0009267	cellular response to starvation
0.35	GO:0071805	potassium ion transmembrane transport
0.35	GO:0044265	cellular macromolecule catabolic process

0.70	GO:0070001	aspartic-type peptidase activity
0.65	GO:0004175	endopeptidase activity
0.37	GO:0070492	oligosaccharide binding
0.37	GO:0097718	disordered domain specific binding
0.35	GO:0005249	voltage-gated potassium channel activity
0.32	GO:0016757	transferase activity, transferring glycosyl groups

0.57	GO:0000323	lytic vacuole
0.54	GO:0097208	alveolar lamellar body
0.46	GO:0005615	extracellular space
0.42	GO:0000322	storage vacuole
0.36	GO:0097486	multivesicular body lumen
0.36	GO:1903561	extracellular vesicle
0.35	GO:0008076	voltage-gated potassium channel complex
0.34	GO:0043234	protein complex
0.33	GO:0031362	anchored component of external side of plasma membrane
0.33	GO:0009277	fungal-type cell wall

0.32

EC:2.4

GO:0016757

sp|O96011|PX11B_HUMAN
Peroxisomal membrane protein 11B
Search

PEX11B

0.97	Peroxisomal biogenesis factor 11 beta

0.82	GO:0016559	peroxisome fission
0.65	GO:0044375	regulation of peroxisome size
0.56	GO:0051260	protein homooligomerization
0.36	GO:0007165	signal transduction

0.55

GO:0042803

protein homodimerization activity

0.79	GO:0005779	integral component of peroxisomal membrane
0.46	GO:0043234	protein complex
0.38	GO:0070062	extracellular exosome
0.35	GO:0005739	mitochondrion

sp|O96013|PAK4_HUMAN
Serine/threonine-protein kinase PAK 4
Search

PAK4

0.85	Serine/threonine-protein kinase PAK 4

0.63	GO:0006468	protein phosphorylation
0.59	GO:0060996	dendritic spine development
0.56	GO:2000352	negative regulation of endothelial cell apoptotic process
0.54	GO:0045766	positive regulation of angiogenesis
0.53	GO:0071407	cellular response to organic cyclic compound
0.51	GO:0098609	cell-cell adhesion
0.46	GO:0007266	Rho protein signal transduction
0.45	GO:0031098	stress-activated protein kinase signaling cascade
0.44	GO:0032147	activation of protein kinase activity
0.44	GO:0043408	regulation of MAPK cascade

0.65	GO:0004674	protein serine/threonine kinase activity
0.57	GO:0098641	cadherin binding involved in cell-cell adhesion
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0048365	Rac GTPase binding

0.54	GO:0005913	cell-cell adherens junction
0.41	GO:0005925	focal adhesion
0.39	GO:0005794	Golgi apparatus

0.65

GO:0004674

sp|O96014|WNT11_HUMAN
Protein Wnt-11
Search

sp|O96015|DNAL4_HUMAN
Dynein light chain 4, axonemal
Search

DNAL4

0.96	Dynein axonemal light chain 4

0.68	GO:0007017	microtubule-based process
0.50	GO:2000580	regulation of ATP-dependent microtubule motor activity, plus-end-directed
0.50	GO:2000576	positive regulation of microtubule motor activity
0.47	GO:0032781	positive regulation of ATPase activity
0.34	GO:0006928	movement of cell or subcellular component

0.49	GO:0051959	dynein light intermediate chain binding
0.49	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed
0.49	GO:0045505	dynein intermediate chain binding
0.44	GO:0008092	cytoskeletal protein binding

0.75	GO:0030286	dynein complex
0.38	GO:0005929	cilium
0.37	GO:0005874	microtubule
0.33	GO:0005737	cytoplasm
0.32	GO:0005886	plasma membrane

0.49

EC:3.6.4.4

GO:0008574

sp|O96017|CHK2_HUMAN
Serine/threonine-protein kinase Chk2
Search

CHEK2

0.91	Checkpoint and tumor suppressor protein 2

0.77	GO:0006975	DNA damage induced protein phosphorylation
0.76	GO:0072428	signal transduction involved in intra-S DNA damage checkpoint
0.72	GO:0000086	G2/M transition of mitotic cell cycle
0.72	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
0.72	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
0.72	GO:0090307	mitotic spindle assembly
0.71	GO:0001302	replicative cell aging
0.71	GO:0071480	cellular response to gamma radiation
0.70	GO:0018105	peptidyl-serine phosphorylation
0.69	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator

0.67	GO:0031625	ubiquitin protein ligase binding
0.67	GO:0019901	protein kinase binding
0.64	GO:0042803	protein homodimerization activity
0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.72	GO:0016605	PML body
0.67	GO:0000781	chromosome, telomeric region
0.61	GO:0005794	Golgi apparatus

sp|O96018|APBA3_HUMAN
Amyloid beta A4 precursor protein-binding family A member 3
Search

APBA3

0.96	Amyloid beta precursor protein binding family A member 3

0.69	GO:0043086	negative regulation of catalytic activity
0.58	GO:0007268	chemical synaptic transmission
0.54	GO:0001701	in utero embryonic development
0.43	GO:0060255	regulation of macromolecule metabolic process
0.43	GO:0006461	protein complex assembly
0.38	GO:0015031	protein transport
0.37	GO:0014051	gamma-aminobutyric acid secretion
0.36	GO:0014047	glutamate secretion
0.36	GO:0035264	multicellular organism growth
0.35	GO:0007626	locomotory behavior

0.85	GO:0001540	amyloid-beta binding
0.71	GO:0004857	enzyme inhibitor activity
0.50	GO:0019899	enzyme binding

0.54	GO:0048471	perinuclear region of cytoplasm
0.48	GO:0008021	synaptic vesicle
0.34	GO:0005794	Golgi apparatus
0.30	GO:0016020	membrane

sp|O96019|ACL6A_HUMAN
Actin-like protein 6A
Search

ACTL6A

0.59	BRG1/brm-associated factor 53A

0.76	GO:0043044	ATP-dependent chromatin remodeling
0.55	GO:1903146	regulation of autophagy of mitochondrion
0.55	GO:0043968	histone H2A acetylation
0.54	GO:0007399	nervous system development
0.54	GO:0003407	neural retina development
0.54	GO:1903955	positive regulation of protein targeting to mitochondrion
0.54	GO:0043967	histone H4 acetylation
0.37	GO:0040008	regulation of growth
0.36	GO:0006351	transcription, DNA-templated
0.36	GO:1903506	regulation of nucleic acid-templated transcription

0.50	GO:0003682	chromatin binding
0.37	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.36	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.36	GO:0003713	transcription coactivator activity
0.35	GO:0044877	macromolecular complex binding
0.35	GO:0005515	protein binding
0.34	GO:0005200	structural constituent of cytoskeleton

0.79	GO:0071564	npBAF complex
0.59	GO:0016514	SWI/SNF complex
0.52	GO:0035267	NuA4 histone acetyltransferase complex
0.51	GO:0031011	Ino80 complex
0.49	GO:0071565	nBAF complex
0.45	GO:0005730	nucleolus
0.41	GO:0005886	plasma membrane

sp|O96020|CCNE2_HUMAN
G1/S-specific cyclin-E2
Search

CCNE2

0.97	G1/S-specific cyclin-E2 isoform A

0.83	GO:0000082	G1/S transition of mitotic cell cycle
0.73	GO:0051726	regulation of cell cycle
0.57	GO:0007129	synapsis
0.54	GO:0000723	telomere maintenance
0.53	GO:1903827	regulation of cellular protein localization
0.53	GO:0045859	regulation of protein kinase activity
0.53	GO:0006270	DNA replication initiation
0.38	GO:0000122	negative regulation of transcription by RNA polymerase II
0.38	GO:0016055	Wnt signaling pathway
0.38	GO:0051301	cell division

0.56	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.42	GO:0019901	protein kinase binding
0.35	GO:0016301	kinase activity
0.33	GO:0032403	protein complex binding

0.61	GO:0005634	nucleus
0.60	GO:0097135	cyclin E2-CDK2 complex
0.41	GO:0097134	cyclin E1-CDK2 complex
0.37	GO:0070013	intracellular organelle lumen
0.35	GO:0044446	intracellular organelle part
0.34	GO:0005829	cytosol
0.33	GO:0015630	microtubule cytoskeleton
0.30	GO:0016020	membrane

0.56

GO:0016538

sp|O96024|B3GT4_HUMAN
Beta-1,3-galactosyltransferase 4
Search

B3GALT4

0.47	Hexosyltransferase

0.74	GO:0006486	protein glycosylation
0.68	GO:0001574	ganglioside biosynthetic process
0.36	GO:0035235	ionotropic glutamate receptor signaling pathway
0.34	GO:0034220	ion transmembrane transport
0.33	GO:0051307	meiotic chromosome separation
0.33	GO:0007194	negative regulation of adenylate cyclase activity
0.33	GO:0043043	peptide biosynthetic process
0.32	GO:0010467	gene expression
0.32	GO:0007186	G-protein coupled receptor signaling pathway
0.32	GO:0006508	proteolysis

0.80	GO:0008378	galactosyltransferase activity
0.57	GO:0008194	UDP-glycosyltransferase activity
0.36	GO:0030594	neurotransmitter receptor activity
0.36	GO:0008066	glutamate receptor activity
0.36	GO:0005230	extracellular ligand-gated ion channel activity
0.33	GO:0003735	structural constituent of ribosome
0.33	GO:0003723	RNA binding
0.33	GO:0008227	G-protein coupled amine receptor activity
0.33	GO:0004197	cysteine-type endopeptidase activity

0.73	GO:0000139	Golgi membrane
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.80

GO:0008378

sp|O96028|NSD2_HUMAN
Histone-lysine N-methyltransferase NSD2
Search

NSD2

0.48	Histone-lysine N-methyltransferase

0.76	GO:0034968	histone lysine methylation
0.65	GO:0003290	atrial septum secundum morphogenesis
0.65	GO:0003289	atrial septum primum morphogenesis
0.64	GO:0048298	positive regulation of isotype switching to IgA isotypes
0.64	GO:0003149	membranous septum morphogenesis
0.62	GO:2001032	regulation of double-strand break repair via nonhomologous end joining
0.60	GO:0001501	skeletal system development
0.56	GO:0070201	regulation of establishment of protein localization
0.56	GO:0000122	negative regulation of transcription by RNA polymerase II
0.43	GO:0061448	connective tissue development

0.77	GO:0018024	histone-lysine N-methyltransferase activity
0.56	GO:0003682	chromatin binding
0.53	GO:0046872	metal ion binding
0.50	GO:0003677	DNA binding
0.39	GO:0050681	androgen receptor binding
0.37	GO:0001067	regulatory region nucleic acid binding
0.37	GO:0003712	transcription cofactor activity

0.61	GO:0005634	nucleus
0.36	GO:0005694	chromosome
0.35	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.33	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.77

EC:2.1.1.43

GO:0018024

sp|O97980|HMHB1_HUMAN
Minor histocompatibility protein HB-1
Search

HMHB1

0.97	Minor histocompatibility protein HB-1

0.87	GO:1902715	positive regulation of interferon-gamma secretion
0.86	GO:0042268	regulation of cytolysis
0.84	GO:0071356	cellular response to tumor necrosis factor
0.83	GO:0002250	adaptive immune response
0.56	GO:0060255	regulation of macromolecule metabolic process

sp|P00156|CYB_HUMAN
Cytochrome b
Search

CYTB

0.41	Cytochrome b

0.71	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c
0.37	GO:0033590	response to cobalamin
0.37	GO:0033762	response to glucagon
0.36	GO:0055093	response to hyperoxia
0.36	GO:0031100	animal organ regeneration
0.36	GO:0042538	hyperosmotic salinity response
0.36	GO:0045471	response to ethanol
0.36	GO:0051592	response to calcium ion
0.36	GO:0046686	response to cadmium ion
0.36	GO:0001666	response to hypoxia

0.71	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
0.62	GO:0009055	electron transfer activity
0.53	GO:0046872	metal ion binding
0.35	GO:0032403	protein complex binding

0.70	GO:0045275	respiratory chain complex III
0.61	GO:0031966	mitochondrial membrane
0.61	GO:0019866	organelle inner membrane
0.35	GO:0031301	integral component of organelle membrane
0.34	GO:0098798	mitochondrial protein complex

0.71

EC:1.10.2

GO:0016681

sp|P00167|CYB5_HUMAN
Cytochrome b5
Search

CYB5A

0.63	Microsomal cytochrome b5 type A

0.41	GO:0071466	cellular response to xenobiotic stimulus
0.39	GO:0046686	response to cadmium ion
0.36	GO:0055114	oxidation-reduction process
0.35	GO:0019852	L-ascorbic acid metabolic process
0.34	GO:0006091	generation of precursor metabolites and energy
0.33	GO:0006631	fatty acid metabolic process
0.33	GO:1902600	hydrogen ion transmembrane transport

0.60	GO:0020037	heme binding
0.52	GO:0046872	metal ion binding
0.48	GO:0019899	enzyme binding
0.35	GO:0004033	aldo-keto reductase (NADP) activity
0.35	GO:0004768	stearoyl-CoA 9-desaturase activity
0.34	GO:0009055	electron transfer activity
0.33	GO:0015002	heme-copper terminal oxidase activity
0.33	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.33	GO:0015078	hydrogen ion transmembrane transporter activity

0.47	GO:0005829	cytosol
0.43	GO:0005739	mitochondrion
0.41	GO:0005789	endoplasmic reticulum membrane
0.38	GO:0031090	organelle membrane
0.36	GO:0070062	extracellular exosome
0.34	GO:0098805	whole membrane
0.34	GO:0031967	organelle envelope
0.33	GO:0019867	outer membrane
0.30	GO:0016021	integral component of membrane

0.35

EC:1.1.1

GO:0004033

sp|P00325|ADH1B_HUMAN
Alcohol dehydrogenase 1B
Search

0.69	Alcohol dehydrogenase E chain

0.53	GO:0055114	oxidation-reduction process
0.50	GO:0006068	ethanol catabolic process
0.49	GO:0042573	retinoic acid metabolic process
0.48	GO:0042572	retinol metabolic process
0.48	GO:0045471	response to ethanol
0.47	GO:0033574	response to testosterone
0.46	GO:0032526	response to retinoic acid
0.45	GO:0030534	adult behavior
0.44	GO:0048545	response to steroid hormone
0.40	GO:1900116	extracellular negative regulation of signal transduction

0.63	GO:0008270	zinc ion binding
0.56	GO:0004022	alcohol dehydrogenase (NAD) activity
0.43	GO:0004745	retinol dehydrogenase activity
0.43	GO:0042803	protein homodimerization activity
0.42	GO:0035276	ethanol binding
0.41	GO:0004031	aldehyde oxidase activity
0.41	GO:0019841	retinol binding
0.40	GO:0048019	receptor antagonist activity
0.34	GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase activity
0.33	GO:0051287	NAD binding

0.44	GO:0005829	cytosol
0.42	GO:0005654	nucleoplasm
0.39	GO:0005886	plasma membrane
0.39	GO:0005739	mitochondrion
0.36	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.56	EC:1.1.1.1	GO:0004022
0.34	KEGG:R06983 KEGG:R07140	GO:0051903

sp|P00326|ADH1G_HUMAN
Alcohol dehydrogenase 1C
Search

0.70	Alcohol dehydrogenase E chain

0.52	GO:0055114	oxidation-reduction process
0.46	GO:0006067	ethanol metabolic process
0.42	GO:0001523	retinoid metabolic process
0.42	GO:0045471	response to ethanol
0.41	GO:0033574	response to testosterone
0.41	GO:0034310	primary alcohol catabolic process
0.40	GO:0032526	response to retinoic acid
0.40	GO:0034754	cellular hormone metabolic process
0.40	GO:0030534	adult behavior
0.39	GO:0048545	response to steroid hormone

0.62	GO:0008270	zinc ion binding
0.56	GO:0004022	alcohol dehydrogenase (NAD) activity
0.42	GO:0004745	retinol dehydrogenase activity
0.39	GO:0035276	ethanol binding
0.38	GO:0042803	protein homodimerization activity
0.37	GO:0004031	aldehyde oxidase activity
0.37	GO:0019841	retinol binding
0.37	GO:0048019	receptor antagonist activity
0.34	GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase activity
0.34	GO:0051287	NAD binding

0.44	GO:0005829	cytosol
0.43	GO:0005654	nucleoplasm
0.39	GO:0005886	plasma membrane
0.36	GO:0005739	mitochondrion
0.34	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.56	EC:1.1.1.1	GO:0004022
0.34	KEGG:R06983 KEGG:R07140	GO:0051903

sp|P00338|LDHA_HUMAN
L-lactate dehydrogenase A chain
Search

LDHA

0.54	L-lactate dehydrogenase A chain

0.60	GO:0005975	carbohydrate metabolic process
0.57	GO:0019752	carboxylic acid metabolic process
0.52	GO:0055114	oxidation-reduction process
0.38	GO:0051591	response to cAMP
0.38	GO:0043627	response to estrogen
0.37	GO:0009749	response to glucose
0.37	GO:0042542	response to hydrogen peroxide
0.37	GO:0048569	post-embryonic animal organ development
0.37	GO:0001666	response to hypoxia
0.37	GO:0007584	response to nutrient

0.81	GO:0004459	L-lactate dehydrogenase activity
0.42	GO:0045296	cadherin binding
0.37	GO:0019900	kinase binding
0.36	GO:0042802	identical protein binding
0.35	GO:0051287	NAD binding

0.48	GO:0005737	cytoplasm
0.37	GO:0035686	sperm fibrous sheath
0.36	GO:0070062	extracellular exosome
0.36	GO:0000439	core TFIIH complex
0.30	GO:0016020	membrane

0.81

EC:1.1.1.27

GO:0004459

sp|P00352|AL1A1_HUMAN
Retinal dehydrogenase 1
Search

ALDH1A1

0.81	Retinal dehydrogenase 1

0.53	GO:0055114	oxidation-reduction process
0.52	GO:0042572	retinol metabolic process
0.43	GO:0042905	9-cis-retinoic acid metabolic process
0.43	GO:0002072	optic cup morphogenesis involved in camera-type eye development
0.42	GO:0002138	retinoic acid biosynthetic process
0.40	GO:0043065	positive regulation of apoptotic process
0.39	GO:0061624	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
0.38	GO:0042493	response to drug
0.38	GO:0044849	estrous cycle
0.37	GO:0007494	midgut development

0.69	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.41	GO:0051287	NAD binding
0.38	GO:0005497	androgen binding
0.36	GO:0005096	GTPase activator activity
0.35	GO:0042802	identical protein binding

0.48	GO:0005829	cytosol
0.39	GO:0070062	extracellular exosome
0.34	GO:0005634	nucleus

0.69

EC:1.2.1

GO:0016620

sp|P00367|DHE3_HUMAN
Glutamate dehydrogenase 1, mitochondrial
Search

GLUD1

0.45	Glutamate dehydrogenase

0.57	GO:0006520	cellular amino acid metabolic process
0.50	GO:0055114	oxidation-reduction process
0.47	GO:0032024	positive regulation of insulin secretion
0.43	GO:0072350	tricarboxylic acid metabolic process
0.42	GO:0043649	dicarboxylic acid catabolic process
0.40	GO:0032094	response to food
0.39	GO:0043650	dicarboxylic acid biosynthetic process
0.39	GO:1901565	organonitrogen compound catabolic process
0.38	GO:0021762	substantia nigra development
0.38	GO:0010044	response to aluminum ion

0.71	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
0.44	GO:0070728	leucine binding
0.40	GO:0043531	ADP binding
0.39	GO:0032550	purine ribonucleoside binding
0.39	GO:0019001	guanyl nucleotide binding
0.38	GO:0070403	NAD+ binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0005515	protein binding
0.35	GO:0008144	drug binding

0.46	GO:0005759	mitochondrial matrix
0.40	GO:0031966	mitochondrial membrane
0.40	GO:0019866	organelle inner membrane

0.71

EC:1.4.1

GO:0016639

sp|P00374|DYR_HUMAN
Dihydrofolate reductase
Search

DHFR

0.45	Viral dihydrofolate reductase

0.75	GO:0046654	tetrahydrofolate biosynthetic process
0.53	GO:0055114	oxidation-reduction process
0.49	GO:0051000	positive regulation of nitric-oxide synthase activity
0.49	GO:2000121	regulation of removal of superoxide radicals
0.48	GO:0046146	tetrahydrobiopterin metabolic process
0.48	GO:0034312	diol biosynthetic process
0.45	GO:0031427	response to methotrexate
0.44	GO:0046452	dihydrofolate metabolic process
0.43	GO:0003232	bulbus arteriosus development
0.42	GO:0046655	folic acid metabolic process

0.79	GO:0004146	dihydrofolate reductase activity
0.45	GO:0051870	methotrexate binding
0.44	GO:1990825	sequence-specific mRNA binding
0.44	GO:0000900	translation repressor activity, nucleic acid binding
0.42	GO:0005542	folic acid binding
0.41	GO:0070402	NADPH binding
0.40	GO:0051871	dihydrofolic acid binding
0.37	GO:0033560	folate reductase activity
0.33	GO:0016757	transferase activity, transferring glycosyl groups
0.33	GO:0005515	protein binding

0.43	GO:0005739	mitochondrion
0.35	GO:0005829	cytosol
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0019866	organelle inner membrane
0.34	GO:0000439	core TFIIH complex
0.30	GO:0016021	integral component of membrane

0.79

EC:1.5.1.3

GO:0004146

sp|P00387|NB5R3_HUMAN
NADH-cytochrome b5 reductase 3
Search

CYB5R3

0.64	NADH-cytochrome b5 reductase

0.52	GO:0055114	oxidation-reduction process
0.42	GO:0006695	cholesterol biosynthetic process
0.35	GO:0043312	neutrophil degranulation
0.35	GO:0019852	L-ascorbic acid metabolic process
0.35	GO:0008015	blood circulation
0.34	GO:0006805	xenobiotic metabolic process

0.79	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H
0.37	GO:0016208	AMP binding
0.37	GO:0043531	ADP binding
0.37	GO:0050660	flavin adenine dinucleotide binding
0.36	GO:0051287	NAD binding
0.34	GO:0005515	protein binding

0.50	GO:0005811	lipid droplet
0.47	GO:0005783	endoplasmic reticulum
0.44	GO:0031966	mitochondrial membrane
0.43	GO:0019866	organelle inner membrane
0.40	GO:0031968	organelle outer membrane
0.39	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.38	GO:0031984	organelle subcompartment
0.38	GO:0070062	extracellular exosome
0.36	GO:0035578	azurophil granule lumen
0.35	GO:0005833	hemoglobin complex

0.79

EC:1.6.2.2

GO:0004128

sp|P00390|GSHR_HUMAN
Glutathione reductase, mitochondrial
Search

GSR

0.52	Glutathione-disulfide reductase

0.74	GO:0006749	glutathione metabolic process
0.68	GO:0098869	cellular oxidant detoxification
0.66	GO:0045454	cell redox homeostasis
0.54	GO:0022900	electron transport chain
0.37	GO:0015949	nucleobase-containing small molecule interconversion
0.36	GO:0010041	response to iron(III) ion
0.36	GO:0006979	response to oxidative stress
0.36	GO:0033189	response to vitamin A
0.36	GO:0002931	response to ischemia
0.36	GO:0014823	response to activity

0.81	GO:0004362	glutathione-disulfide reductase activity
0.69	GO:0050661	NADP binding
0.65	GO:0050660	flavin adenine dinucleotide binding
0.55	GO:0009055	electron transfer activity
0.37	GO:0098622	selenodiglutathione-disulfide reductase activity
0.35	GO:0043295	glutathione binding
0.34	GO:0042803	protein homodimerization activity
0.32	GO:0004601	peroxidase activity

0.53	GO:0009897	external side of plasma membrane
0.44	GO:0005739	mitochondrion
0.38	GO:0070062	extracellular exosome
0.36	GO:0005829	cytosol
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part

0.81	EC:1.8.1.7	GO:0004362
0.32	KEGG:R03532	GO:0004601

sp|P00395|COX1_HUMAN
Cytochrome c oxidase subunit 1
Search

COX1

0.29	Cytochrome c oxidase subunit 1

0.64	GO:0006119	oxidative phosphorylation
0.64	GO:0009060	aerobic respiration
0.63	GO:1902600	hydrogen ion transmembrane transport
0.61	GO:0022900	electron transport chain
0.30	GO:0051602	response to electrical stimulus
0.30	GO:0060322	head development
0.30	GO:0048731	system development
0.30	GO:0007568	aging
0.30	GO:0046688	response to copper ion
0.30	GO:0006950	response to stress

0.65	GO:0015002	heme-copper terminal oxidase activity
0.65	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.63	GO:0020037	heme binding
0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.63	GO:0005506	iron ion binding
0.62	GO:0009055	electron transfer activity
0.30	GO:0005515	protein binding

0.75	GO:0045277	respiratory chain complex IV
0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane
0.30	GO:1902494	catalytic complex
0.30	GO:0098798	mitochondrial protein complex

0.65

GO:0016676

sp|P00403|COX2_HUMAN
Cytochrome c oxidase subunit 2
Search

COX2

0.41	Cytochrome c oxidase subunit 2

0.63	GO:1902600	hydrogen ion transmembrane transport
0.61	GO:0022900	electron transport chain
0.36	GO:0007595	lactation
0.36	GO:0009409	response to cold
0.33	GO:0006119	oxidative phosphorylation
0.33	GO:0009060	aerobic respiration

0.72	GO:0005507	copper ion binding
0.65	GO:0015002	heme-copper terminal oxidase activity
0.65	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.62	GO:0009055	electron transfer activity
0.33	GO:0005515	protein binding

0.62	GO:0070469	respiratory chain
0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane
0.34	GO:0070062	extracellular exosome
0.34	GO:0098798	mitochondrial protein complex
0.33	GO:0070069	cytochrome complex
0.33	GO:0098796	membrane protein complex
0.30	GO:0016021	integral component of membrane

0.65

GO:0016676

sp|P00414|COX3_HUMAN
Cytochrome c oxidase subunit 3
Search

COX3

0.45	Cytochrome c oxidase subunit 3

0.76	GO:0019646	aerobic electron transport chain
0.63	GO:1902600	hydrogen ion transmembrane transport
0.34	GO:0008535	respiratory chain complex IV assembly
0.33	GO:0042775	mitochondrial ATP synthesis coupled electron transport

0.65	GO:0015002	heme-copper terminal oxidase activity
0.65	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.62	GO:0009055	electron transfer activity
0.33	GO:0005515	protein binding

0.61	GO:0005739	mitochondrion
0.34	GO:0045277	respiratory chain complex IV
0.33	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.65

GO:0016676

sp|P00439|PH4H_HUMAN
Phenylalanine-4-hydroxylase
Search

PAH

0.64	Phenylalanine hydroxylase

0.77	GO:1902222	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process
0.75	GO:0006558	L-phenylalanine metabolic process
0.73	GO:0009074	aromatic amino acid family catabolic process
0.68	GO:0042737	drug catabolic process
0.53	GO:0055114	oxidation-reduction process
0.44	GO:0071391	cellular response to estrogen stimulus
0.35	GO:0042423	catecholamine biosynthetic process
0.35	GO:0018126	protein hydroxylation
0.34	GO:0046146	tetrahydrobiopterin metabolic process
0.34	GO:0006571	tyrosine biosynthetic process

0.83	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
0.63	GO:0005506	iron ion binding
0.34	GO:0016597	amino acid binding
0.34	GO:0042803	protein homodimerization activity
0.32	GO:0048037	cofactor binding

0.36	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol

0.83

EC:1.14.16

GO:0016714

sp|P00441|SODC_HUMAN
Superoxide dismutase [Cu-Zn]
Search

SOD1

0.55	Superoxide dismutase [Cu-Zn]

0.75	GO:0071450	cellular response to oxygen radical
0.75	GO:0006801	superoxide metabolic process
0.75	GO:0000303	response to superoxide
0.69	GO:0098869	cellular oxidant detoxification
0.60	GO:0045541	negative regulation of cholesterol biosynthetic process
0.59	GO:0060087	relaxation of vascular smooth muscle
0.58	GO:0050665	hydrogen peroxide biosynthetic process
0.58	GO:0060088	auditory receptor cell stereocilium organization
0.58	GO:0032287	peripheral nervous system myelin maintenance
0.58	GO:0060052	neurofilament cytoskeleton organization

0.77	GO:0004784	superoxide dismutase activity
0.60	GO:0030346	protein phosphatase 2B binding
0.54	GO:0046872	metal ion binding
0.54	GO:0048365	Rac GTPase binding
0.53	GO:0051087	chaperone binding
0.49	GO:0042802	identical protein binding
0.36	GO:0046983	protein dimerization activity
0.34	GO:0004842	ubiquitin-protein transferase activity

0.58	GO:0032839	dendrite cytoplasm
0.55	GO:0043025	neuronal cell body
0.53	GO:1904115	axon cytoplasm
0.53	GO:0005615	extracellular space
0.52	GO:0043209	myelin sheath
0.51	GO:0031012	extracellular matrix
0.50	GO:0031410	cytoplasmic vesicle
0.50	GO:0005777	peroxisome
0.49	GO:0005829	cytosol
0.47	GO:0005654	nucleoplasm

0.77	EC:1.15.1.1	GO:0004784
0.34	KEGG:R03876	GO:0004842

sp|P00450|CERU_HUMAN
Ceruloplasmin
Search

0.10	Ceruloplasmin

0.78	GO:0006825	copper ion transport
0.76	GO:0006879	cellular iron ion homeostasis
0.53	GO:0055114	oxidation-reduction process
0.30	GO:0043687	post-translational protein modification

0.81	GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor
0.72	GO:0005507	copper ion binding
0.56	GO:0051087	chaperone binding

0.54	GO:0005615	extracellular space
0.30	GO:0016020	membrane
0.30	GO:0044464	cell part
0.30	GO:1903561	extracellular vesicle
0.30	GO:0043233	organelle lumen

0.81

EC:1.16.3

GO:0016724

sp|P00451|FA8_HUMAN
Coagulation factor VIII
Search

0.57	Coagulation factor VIII

0.85	GO:0030168	platelet activation
0.49	GO:0055114	oxidation-reduction process
0.38	GO:0006953	acute-phase response
0.34	GO:0007597	blood coagulation, intrinsic pathway
0.30	GO:0061024	membrane organization
0.30	GO:0002576	platelet degranulation
0.30	GO:0051641	cellular localization
0.30	GO:0048193	Golgi vesicle transport
0.30	GO:0016050	vesicle organization
0.30	GO:0065003	macromolecular complex assembly

0.66	GO:0005507	copper ion binding
0.49	GO:0016491	oxidoreductase activity
0.34	GO:0003676	nucleic acid binding
0.30	GO:0005515	protein binding

0.37	GO:0005615	extracellular space
0.30	GO:0044422	organelle part
0.30	GO:0016020	membrane
0.30	GO:0044464	cell part
0.30	GO:0031982	vesicle
0.30	GO:0031974	membrane-enclosed lumen

0.49

GO:0016491

sp|P00480|OTC_HUMAN
Ornithine carbamoyltransferase, mitochondrial
Search

OTC

0.45	Ornithine carbamoyltransferase

0.66	GO:0019240	citrulline biosynthetic process
0.66	GO:0000050	urea cycle
0.65	GO:0097272	ammonia homeostasis
0.64	GO:0006593	ornithine catabolic process
0.50	GO:0042450	arginine biosynthetic process via ornithine
0.44	GO:0070781	response to biotin
0.42	GO:0007494	midgut development
0.42	GO:0070207	protein homotrimerization
0.42	GO:0010043	response to zinc ion
0.41	GO:0001889	liver development

0.75	GO:0016743	carboxyl- or carbamoyltransferase activity
0.75	GO:0016597	amino acid binding
0.40	GO:0042301	phosphate ion binding
0.39	GO:0005543	phospholipid binding

0.50	GO:0005739	mitochondrion
0.49	GO:0019866	organelle inner membrane
0.41	GO:0031974	membrane-enclosed lumen
0.36	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.75

EC:2.1.3

GO:0016743

sp|P00488|F13A_HUMAN
Coagulation factor XIII A chain
Search

F13A1

0.87	Coagulation factor XIII A chain

0.85	GO:0072378	blood coagulation, fibrin clot formation
0.84	GO:0018149	peptide cross-linking
0.36	GO:0002576	platelet degranulation
0.35	GO:0019221	cytokine-mediated signaling pathway
0.33	GO:0006418	tRNA aminoacylation for protein translation

0.84	GO:0003810	protein-glutamine gamma-glutamyltransferase activity
0.34	GO:0046872	metal ion binding
0.33	GO:0016875	ligase activity, forming carbon-oxygen bonds
0.32	GO:0140101	catalytic activity, acting on a tRNA
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.38	GO:0072562	blood microparticle
0.37	GO:0031093	platelet alpha granule lumen

0.84

EC:2.3.2.13

GO:0003810

sp|P00491|PNPH_HUMAN
Purine nucleoside phosphorylase
Search

PNP

0.47	Purine nucleoside phosphorylase

0.66	GO:0009116	nucleoside metabolic process
0.56	GO:0034418	urate biosynthetic process
0.55	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway
0.55	GO:0070970	interleukin-2 secretion
0.53	GO:0046638	positive regulation of alpha-beta T cell differentiation
0.52	GO:0042102	positive regulation of T cell proliferation
0.52	GO:0072526	pyridine-containing compound catabolic process
0.51	GO:1901658	glycosyl compound catabolic process
0.50	GO:0072523	purine-containing compound catabolic process
0.47	GO:0006955	immune response

0.78	GO:0004731	purine-nucleoside phosphorylase activity
0.56	GO:0002060	purine nucleobase binding
0.50	GO:0042301	phosphate ion binding
0.45	GO:0001882	nucleoside binding
0.41	GO:0047724	inosine nucleosidase activity
0.40	GO:0070635	nicotinamide riboside hydrolase activity
0.40	GO:0008144	drug binding

0.46	GO:0005829	cytosol
0.37	GO:0005856	cytoskeleton
0.36	GO:0070062	extracellular exosome
0.36	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0034774	secretory granule lumen
0.35	GO:0005634	nucleus
0.30	GO:0044425	membrane part

0.78

EC:2.4.2.1

GO:0004731

sp|P00492|HPRT_HUMAN
Hypoxanthine-guanine phosphoribosyltransferase
Search

HPRT1

0.50	Hypoxanthine-guanine phosphoribosyltransferase

0.78	GO:0032264	IMP salvage
0.75	GO:0006166	purine ribonucleoside salvage
0.59	GO:0046038	GMP catabolic process
0.58	GO:0006178	guanine salvage
0.58	GO:0045964	positive regulation of dopamine metabolic process
0.54	GO:0051289	protein homotetramerization
0.54	GO:0046100	hypoxanthine metabolic process
0.54	GO:0007625	grooming behavior
0.54	GO:0021756	striatum development
0.54	GO:0001975	response to amphetamine

0.79	GO:0004422	hypoxanthine phosphoribosyltransferase activity
0.79	GO:0052657	guanine phosphoribosyltransferase activity
0.53	GO:0046872	metal ion binding
0.52	GO:1901265	nucleoside phosphate binding
0.50	GO:0036094	small molecule binding
0.50	GO:0042803	protein homodimerization activity

0.48	GO:0005737	cytoplasm
0.36	GO:0070062	extracellular exosome
0.33	GO:0005694	chromosome

0.79	EC:2.4.2.8	GO:0004422
0.79	KEGG:R01132	GO:0004422

sp|P00505|AATM_HUMAN
Aspartate aminotransferase, mitochondrial
Search

GOT2

0.49	Aspartate aminotransferase

0.59	GO:0006520	cellular amino acid metabolic process
0.53	GO:0043649	dicarboxylic acid catabolic process
0.52	GO:0045471	response to ethanol
0.50	GO:0015908	fatty acid transport
0.49	GO:0006103	2-oxoglutarate metabolic process
0.48	GO:0009058	biosynthetic process
0.46	GO:0006107	oxaloacetate metabolic process
0.46	GO:1901565	organonitrogen compound catabolic process
0.45	GO:0006106	fumarate metabolic process
0.41	GO:0042537	benzene-containing compound metabolic process

0.81	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity
0.77	GO:0070546	L-phenylalanine aminotransferase activity
0.66	GO:0030170	pyridoxal phosphate binding
0.45	GO:0016212	kynurenine-oxoglutarate transaminase activity
0.38	GO:0042803	protein homodimerization activity
0.37	GO:0016597	amino acid binding
0.37	GO:0005543	phospholipid binding
0.36	GO:0047578	4-hydroxyglutamate transaminase activity
0.36	GO:0019899	enzyme binding
0.34	GO:0003723	RNA binding

0.47	GO:0043209	myelin sheath
0.44	GO:0005739	mitochondrion
0.41	GO:0005886	plasma membrane
0.40	GO:0019866	organelle inner membrane
0.40	GO:0070013	intracellular organelle lumen
0.38	GO:0043204	perikaryon
0.38	GO:0009986	cell surface
0.36	GO:0070062	extracellular exosome
0.34	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

0.81	EC:2.6.1.1	GO:0004069
0.81	KEGG:R00355	GO:0004069

sp|P00519|ABL1_HUMAN
Tyrosine-protein kinase ABL1
Search

ABL1

0.57	Tyrosine-protein kinase

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.62	GO:1904531	positive regulation of actin filament binding
0.62	GO:0002333	transitional one stage B cell differentiation
0.61	GO:1900275	negative regulation of phospholipase C activity
0.61	GO:1990051	activation of protein kinase C activity
0.61	GO:0038189	neuropilin signaling pathway
0.61	GO:1905555	positive regulation blood vessel branching
0.61	GO:0090135	actin filament branching
0.61	GO:1904528	positive regulation of microtubule binding
0.61	GO:1905244	regulation of modification of synaptic structure

0.81	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.59	GO:0038191	neuropilin binding
0.59	GO:0070064	proline-rich region binding
0.59	GO:0051019	mitogen-activated protein kinase binding
0.58	GO:0042169	SH2 domain binding
0.58	GO:0005080	protein kinase C binding
0.57	GO:0001784	phosphotyrosine residue binding
0.57	GO:0046875	ephrin receptor binding
0.56	GO:0019905	syntaxin binding
0.56	GO:0008022	protein C-terminus binding

0.54	GO:0031252	cell leading edge
0.54	GO:0048471	perinuclear region of cytoplasm
0.52	GO:0016604	nuclear body
0.51	GO:0005730	nucleolus
0.51	GO:0015629	actin cytoskeleton
0.49	GO:0005829	cytosol
0.46	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.44	GO:0043234	protein complex
0.40	GO:0043005	neuron projection
0.40	GO:0043025	neuronal cell body

0.81

EC:2.7.10.2

GO:0004715

sp|P00533|EGFR_HUMAN
Epidermal growth factor receptor
Search

EGFR

0.65	Receptor protein-tyrosine kinase

0.75	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.74	GO:0018108	peptidyl-tyrosine phosphorylation
0.63	GO:0023014	signal transduction by protein phosphorylation
0.60	GO:0035556	intracellular signal transduction
0.56	GO:0010750	positive regulation of nitric oxide mediated signal transduction
0.55	GO:1900020	positive regulation of protein kinase C activity
0.54	GO:0031659	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
0.54	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA
0.54	GO:0070141	response to UV-A
0.54	GO:0035413	positive regulation of catenin import into nucleus

0.83	GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity
0.78	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.55	GO:0030235	nitric-oxide synthase regulator activity
0.53	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0019903	protein phosphatase binding
0.50	GO:0045296	cadherin binding
0.50	GO:0031625	ubiquitin protein ligase binding

0.56	GO:0097489	multivesicular body, internal vesicle lumen
0.52	GO:0031901	early endosome membrane
0.51	GO:0016323	basolateral plasma membrane
0.50	GO:0098857	membrane microdomain
0.49	GO:0043235	receptor complex
0.48	GO:0009986	cell surface
0.43	GO:0030139	endocytic vesicle
0.43	GO:0048471	perinuclear region of cytoplasm
0.42	GO:0005634	nucleus
0.42	GO:0043234	protein complex

0.83

GO:0004716

sp|P00540|MOS_HUMAN
Proto-oncogene serine/threonine-protein kinase mos
Search

0.54	Serine/threonine-protein kinase-transforming protein mos

0.63	GO:0006468	protein phosphorylation
0.48	GO:1902103	negative regulation of metaphase/anaphase transition of meiotic cell cycle
0.47	GO:0051296	establishment of meiotic spindle orientation
0.45	GO:0043410	positive regulation of MAPK cascade
0.45	GO:0000212	meiotic spindle organization
0.44	GO:0043405	regulation of MAP kinase activity
0.44	GO:0032147	activation of protein kinase activity
0.44	GO:0071902	positive regulation of protein serine/threonine kinase activity
0.41	GO:0006325	chromatin organization
0.40	GO:0035556	intracellular signal transduction

0.64	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0005057	signal transducer activity, downstream of receptor
0.35	GO:0004713	protein tyrosine kinase activity
0.34	GO:0005198	structural molecule activity
0.34	GO:0005515	protein binding
0.33	GO:0003723	RNA binding

0.36	GO:0005737	cytoplasm
0.34	GO:0019028	viral capsid
0.33	GO:0036338	viral membrane
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0044446	intracellular organelle part

0.64

GO:0004674

sp|P00558|PGK1_HUMAN
Phosphoglycerate kinase 1
Search

PGK1

0.46	Phosphoglycerate kinase

0.70	GO:0006757	ATP generation from ADP
0.69	GO:0006090	pyruvate metabolic process
0.68	GO:0016052	carbohydrate catabolic process
0.67	GO:0019362	pyridine nucleotide metabolic process
0.51	GO:0001666	response to hypoxia
0.48	GO:0031639	plasminogen activation
0.47	GO:0036294	cellular response to decreased oxygen levels
0.47	GO:0016525	negative regulation of angiogenesis
0.46	GO:1903862	positive regulation of oxidative phosphorylation
0.45	GO:0030855	epithelial cell differentiation

0.79	GO:0004618	phosphoglycerate kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0047134	protein-disulfide reductase activity
0.33	GO:0005515	protein binding

0.46	GO:0045121	membrane raft
0.44	GO:0005615	extracellular space
0.40	GO:0035686	sperm fibrous sheath
0.37	GO:1903561	extracellular vesicle
0.36	GO:0005737	cytoplasm
0.33	GO:0005694	chromosome
0.33	GO:0005634	nucleus

0.79	EC:2.7.2.3	GO:0004618
0.79	KEGG:R01512	GO:0004618

sp|P00568|KAD1_HUMAN
Adenylate kinase isoenzyme 1
Search

AK1

0.91	Adenylate kinase isoenzyme 1

0.77	GO:0006172	ADP biosynthetic process
0.67	GO:0046033	AMP metabolic process
0.66	GO:0046939	nucleotide phosphorylation
0.64	GO:0009142	nucleoside triphosphate biosynthetic process
0.60	GO:0046034	ATP metabolic process
0.52	GO:0007050	cell cycle arrest
0.37	GO:0097503	sialylation
0.37	GO:0033993	response to lipid
0.36	GO:0006486	protein glycosylation
0.36	GO:1901700	response to oxygen-containing compound

0.74	GO:0004017	adenylate kinase activity
0.74	GO:0004550	nucleoside diphosphate kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0008373	sialyltransferase activity
0.35	GO:0030695	GTPase regulator activity
0.35	GO:0019206	nucleoside kinase activity

0.54	GO:0001520	outer dense fiber
0.48	GO:0005829	cytosol
0.41	GO:0005886	plasma membrane
0.36	GO:0005815	microtubule organizing center
0.36	GO:0070062	extracellular exosome
0.35	GO:0030017	sarcomere
0.34	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0043005	neuron projection
0.30	GO:0016021	integral component of membrane

0.74

EC:2.7.4.3

GO:0004017

sp|P00709|LALBA_HUMAN
Alpha-lactalbumin
Search

LALBA

0.91	Alpha-lactalbumin protein variant D

0.86	GO:0005989	lactose biosynthetic process
0.45	GO:0042742	defense response to bacterium
0.44	GO:1903496	response to 11-deoxycorticosterone
0.44	GO:1903494	response to dehydroepiandrosterone
0.43	GO:0016998	cell wall macromolecule catabolic process
0.42	GO:0032570	response to progesterone
0.42	GO:0032355	response to estradiol
0.35	GO:0006915	apoptotic process
0.34	GO:0007267	cell-cell signaling
0.33	GO:0009566	fertilization

0.86	GO:0004461	lactose synthase activity
0.68	GO:0005509	calcium ion binding
0.49	GO:0003796	lysozyme activity
0.34	GO:0005515	protein binding
0.32	GO:0004672	protein kinase activity
0.31	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.45	GO:0005576	extracellular region
0.36	GO:0005796	Golgi lumen
0.34	GO:0000139	Golgi membrane
0.30	GO:0031224	intrinsic component of membrane

0.86

EC:2.4.1.22

GO:0004461

sp|P00734|THRB_HUMAN
Prothrombin
Search

0.97	Prothrombin

0.78	GO:0007596	blood coagulation
0.78	GO:0006953	acute-phase response
0.59	GO:0051838	cytolysis by host of symbiont cells
0.58	GO:0006508	proteolysis
0.58	GO:0070945	neutrophil mediated killing of gram-negative bacterium
0.58	GO:1900738	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
0.57	GO:1900016	negative regulation of cytokine production involved in inflammatory response
0.57	GO:0048712	negative regulation of astrocyte differentiation
0.56	GO:0042730	fibrinolysis
0.56	GO:0032967	positive regulation of collagen biosynthetic process

0.67	GO:0005509	calcium ion binding
0.66	GO:0004252	serine-type endopeptidase activity
0.58	GO:0070053	thrombospondin receptor activity
0.53	GO:0008201	heparin binding
0.53	GO:0001530	lipopolysaccharide binding
0.49	GO:0005102	receptor binding
0.36	GO:0030545	receptor regulator activity

0.64	GO:0005576	extracellular region
0.53	GO:0009897	external side of plasma membrane
0.37	GO:0005796	Golgi lumen
0.37	GO:0031982	vesicle
0.37	GO:0005788	endoplasmic reticulum lumen

0.66

GO:0004252

sp|P00736|C1R_HUMAN
Complement C1r subcomponent
Search

C1R

0.97	Complement component 1, r subcomponent

0.74	GO:0006958	complement activation, classical pathway
0.60	GO:0006508	proteolysis
0.49	GO:0051604	protein maturation
0.44	GO:0045087	innate immune response
0.37	GO:0030449	regulation of complement activation
0.33	GO:2001141	regulation of RNA biosynthetic process
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process

0.68	GO:0004252	serine-type endopeptidase activity
0.66	GO:0005509	calcium ion binding
0.34	GO:0005515	protein binding
0.34	GO:0043565	sequence-specific DNA binding
0.33	GO:0003700	DNA binding transcription factor activity

0.53	GO:0005615	extracellular space
0.41	GO:1903561	extracellular vesicle
0.30	GO:0016020	membrane

0.68

GO:0004252

sp|P00738|HPT_HUMAN
Haptoglobin
Search

0.84	Haptoglobin

0.59	GO:0006508	proteolysis
0.52	GO:0007219	Notch signaling pathway
0.49	GO:0006953	acute-phase response
0.46	GO:0042742	defense response to bacterium
0.44	GO:0002376	immune system process
0.43	GO:0098869	cellular oxidant detoxification
0.40	GO:2000296	negative regulation of hydrogen peroxide catabolic process
0.39	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
0.38	GO:0051354	negative regulation of oxidoreductase activity
0.38	GO:0042542	response to hydrogen peroxide

0.81	GO:0030492	hemoglobin binding
0.66	GO:0004252	serine-type endopeptidase activity
0.43	GO:0016209	antioxidant activity
0.39	GO:0004152	dihydroorotate dehydrogenase activity
0.36	GO:0005509	calcium ion binding
0.35	GO:0042803	protein homodimerization activity
0.31	GO:0016740	transferase activity

0.61	GO:0005576	extracellular region
0.39	GO:0031838	haptoglobin-hemoglobin complex
0.36	GO:0031982	vesicle
0.36	GO:1990777	lipoprotein particle
0.34	GO:0005794	Golgi apparatus
0.34	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane
0.30	GO:0043233	organelle lumen
0.30	GO:0044446	intracellular organelle part

0.66	EC:3.4.21	GO:0004252
0.39	KEGG:R01868	GO:0004152

sp|P00739|HPTR_HUMAN
Haptoglobin-related protein
Search

0.84	Haptoglobin

0.58	GO:0006508	proteolysis
0.52	GO:0007219	Notch signaling pathway
0.49	GO:0006953	acute-phase response
0.46	GO:0042742	defense response to bacterium
0.44	GO:0002376	immune system process
0.43	GO:0098869	cellular oxidant detoxification
0.40	GO:2000296	negative regulation of hydrogen peroxide catabolic process
0.38	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
0.38	GO:0051354	negative regulation of oxidoreductase activity
0.38	GO:0042542	response to hydrogen peroxide

0.80	GO:0030492	hemoglobin binding
0.66	GO:0004252	serine-type endopeptidase activity
0.43	GO:0016209	antioxidant activity
0.39	GO:0004152	dihydroorotate dehydrogenase activity
0.36	GO:0005509	calcium ion binding
0.35	GO:0042803	protein homodimerization activity

0.61	GO:0005576	extracellular region
0.39	GO:0031838	haptoglobin-hemoglobin complex
0.36	GO:1990777	lipoprotein particle
0.36	GO:0031982	vesicle
0.34	GO:0005794	Golgi apparatus
0.34	GO:0005783	endoplasmic reticulum
0.30	GO:0016020	membrane

0.66	EC:3.4.21	GO:0004252
0.39	KEGG:R01868	GO:0004152

sp|P00740|FA9_HUMAN
Coagulation factor IX
Search

0.85	Coagulation factor IXb

0.81	GO:0007596	blood coagulation
0.64	GO:0031638	zymogen activation
0.48	GO:0051897	positive regulation of protein kinase B signaling
0.37	GO:0017187	peptidyl-glutamic acid carboxylation
0.37	GO:0072376	protein activation cascade
0.37	GO:0006465	signal peptide processing
0.36	GO:0006888	ER to Golgi vesicle-mediated transport
0.34	GO:0030335	positive regulation of cell migration

0.68	GO:0004252	serine-type endopeptidase activity
0.67	GO:0005509	calcium ion binding
0.45	GO:0005543	phospholipid binding
0.35	GO:0005515	protein binding
0.34	GO:0000287	magnesium ion binding

0.63	GO:0005576	extracellular region
0.38	GO:0005796	Golgi lumen
0.37	GO:0005788	endoplasmic reticulum lumen
0.36	GO:0031982	vesicle
0.34	GO:0031233	intrinsic component of external side of plasma membrane
0.30	GO:0016021	integral component of membrane

0.68

GO:0004252

sp|P00742|FA10_HUMAN
Coagulation factor X
Search

F10

0.85	Coagulation factor IX

0.76	GO:0007596	blood coagulation
0.61	GO:0006508	proteolysis
0.59	GO:0051897	positive regulation of protein kinase B signaling
0.40	GO:0051604	protein maturation
0.40	GO:0035807	positive regulation of blood coagulation in other organism
0.39	GO:0044469	envenomation resulting in positive regulation of blood coagulation in other organism
0.38	GO:0010952	positive regulation of peptidase activity
0.37	GO:0017187	peptidyl-glutamic acid carboxylation
0.37	GO:0072376	protein activation cascade
0.37	GO:0009405	pathogenesis

0.69	GO:0004252	serine-type endopeptidase activity
0.67	GO:0005509	calcium ion binding
0.54	GO:0005543	phospholipid binding
0.39	GO:0016504	peptidase activator activity
0.38	GO:0090729	toxin activity
0.35	GO:0005515	protein binding

0.64	GO:0005576	extracellular region
0.38	GO:0005796	Golgi lumen
0.37	GO:0005788	endoplasmic reticulum lumen
0.36	GO:0031233	intrinsic component of external side of plasma membrane
0.33	GO:0031982	vesicle
0.32	GO:0005765	lysosomal membrane
0.30	GO:0016021	integral component of membrane

0.69

GO:0004252

sp|P00746|CFAD_HUMAN
Complement factor D
Search

CFD

0.75	Complement factor D

0.74	GO:0006957	complement activation, alternative pathway
0.61	GO:0006508	proteolysis
0.42	GO:0008219	cell death
0.38	GO:0019835	cytolysis
0.37	GO:0002576	platelet degranulation
0.37	GO:0043312	neutrophil degranulation
0.36	GO:0044057	regulation of system process
0.36	GO:0048731	system development
0.36	GO:0043616	keratinocyte proliferation
0.36	GO:0120035	regulation of plasma membrane bounded cell projection organization

0.69	GO:0004252	serine-type endopeptidase activity
0.35	GO:0005515	protein binding
0.34	GO:0030552	cAMP binding
0.34	GO:0008201	heparin binding
0.34	GO:0005249	voltage-gated potassium channel activity
0.33	GO:0046872	metal ion binding

0.51	GO:0005615	extracellular space
0.39	GO:1903561	extracellular vesicle
0.38	GO:0030141	secretory granule
0.37	GO:0060205	cytoplasmic vesicle lumen
0.36	GO:0097180	serine protease inhibitor complex
0.34	GO:0005766	primary lysosome
0.34	GO:0005775	vacuolar lumen
0.33	GO:0045177	apical part of cell
0.33	GO:0009986	cell surface
0.32	GO:0097223	sperm part

0.69

GO:0004252

sp|P00747|PLMN_HUMAN
Plasminogen
Search

0.45	Plasminogen

0.69	GO:0042730	fibrinolysis
0.65	GO:0048771	tissue remodeling
0.64	GO:0007596	blood coagulation
0.60	GO:0006508	proteolysis
0.54	GO:0071674	mononuclear cell migration
0.54	GO:0045445	myoblast differentiation
0.54	GO:0046716	muscle cell cellular homeostasis
0.53	GO:0042246	tissue regeneration
0.52	GO:0052213	interaction with symbiont via secreted substance involved in symbiotic interaction
0.52	GO:0060707	trophoblast giant cell differentiation

0.68	GO:0004252	serine-type endopeptidase activity
0.50	GO:1904854	proteasome core complex binding
0.50	GO:0019900	kinase binding
0.49	GO:1990405	protein antigen binding
0.49	GO:0034185	apolipoprotein binding
0.47	GO:0019904	protein domain specific binding
0.46	GO:0005102	receptor binding
0.44	GO:0051087	chaperone binding
0.35	GO:0001968	fibronectin binding

0.54	GO:0005576	extracellular region
0.50	GO:0019897	extrinsic component of plasma membrane
0.46	GO:0009897	external side of plasma membrane
0.41	GO:0044218	other organism cell membrane
0.35	GO:0031982	vesicle
0.35	GO:1990777	lipoprotein particle
0.33	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane
0.30	GO:0043233	organelle lumen
0.30	GO:0012505	endomembrane system

0.68

GO:0004252

sp|P00748|FA12_HUMAN
Coagulation factor XII
Search

F12

0.97	Mutant coagulation factor XII

0.67	GO:0002542	Factor XII activation
0.65	GO:0051919	positive regulation of fibrinolysis
0.65	GO:0010756	positive regulation of plasminogen activation
0.62	GO:0030194	positive regulation of blood coagulation
0.61	GO:0007596	blood coagulation
0.61	GO:0031638	zymogen activation
0.61	GO:0016540	protein autoprocessing
0.60	GO:0051788	response to misfolded protein
0.47	GO:0042730	fibrinolysis
0.40	GO:0006898	receptor-mediated endocytosis

0.69	GO:0004252	serine-type endopeptidase activity
0.62	GO:0005509	calcium ion binding
0.42	GO:0005044	scavenger receptor activity
0.38	GO:0051787	misfolded protein binding
0.33	GO:0003779	actin binding
0.33	GO:0017080	sodium channel regulator activity
0.32	GO:0070008	serine-type exopeptidase activity
0.32	GO:0005216	ion channel activity
0.32	GO:0004222	metalloendopeptidase activity
0.31	GO:0008270	zinc ion binding

0.63	GO:0005615	extracellular space
0.39	GO:1903561	extracellular vesicle
0.34	GO:0005737	cytoplasm
0.34	GO:0031012	extracellular matrix
0.34	GO:0005886	plasma membrane
0.33	GO:0031225	anchored component of membrane
0.33	GO:0019898	extrinsic component of membrane
0.30	GO:0016021	integral component of membrane

0.69

GO:0004252

sp|P00749|UROK_HUMAN
Urokinase-type plasminogen activator
Search

PLAU

0.91	Urokinase-type plasminogen activator

0.80	GO:0031639	plasminogen activation
0.66	GO:2000097	regulation of smooth muscle cell-matrix adhesion
0.65	GO:0014909	smooth muscle cell migration
0.64	GO:0042730	fibrinolysis
0.63	GO:0014910	regulation of smooth muscle cell migration
0.63	GO:0033628	regulation of cell adhesion mediated by integrin
0.60	GO:0001666	response to hypoxia
0.59	GO:0030335	positive regulation of cell migration
0.56	GO:0042127	regulation of cell proliferation
0.56	GO:0010469	regulation of receptor activity

0.69	GO:0004252	serine-type endopeptidase activity
0.49	GO:0016301	kinase activity
0.36	GO:0005044	scavenger receptor activity
0.35	GO:0005515	protein binding
0.33	GO:0008061	chitin binding
0.33	GO:0017080	sodium channel regulator activity
0.33	GO:0015035	protein disulfide oxidoreductase activity
0.33	GO:0008201	heparin binding
0.32	GO:0009055	electron transfer activity
0.32	GO:0004222	metalloendopeptidase activity

0.61	GO:0005576	extracellular region
0.56	GO:0009986	cell surface
0.38	GO:0005925	focal adhesion
0.37	GO:0035579	specific granule membrane
0.37	GO:0070821	tertiary granule membrane
0.35	GO:0031225	anchored component of membrane
0.34	GO:0005886	plasma membrane
0.34	GO:0019898	extrinsic component of membrane
0.30	GO:0016021	integral component of membrane

0.69

GO:0004252

sp|P00750|TPA_HUMAN
Tissue-type plasminogen activator
Search

PLAT

0.95	Salivary plasminogen activator gamma

0.85	GO:0031639	plasminogen activation
0.63	GO:0014909	smooth muscle cell migration
0.61	GO:0048008	platelet-derived growth factor receptor signaling pathway
0.58	GO:0001666	response to hypoxia
0.55	GO:0045861	negative regulation of proteolysis
0.38	GO:0042060	wound healing
0.38	GO:0071373	cellular response to luteinizing hormone stimulus
0.37	GO:0042730	fibrinolysis
0.37	GO:0060279	positive regulation of ovulation
0.37	GO:0071372	cellular response to follicle-stimulating hormone stimulus

0.69	GO:0004252	serine-type endopeptidase activity
0.59	GO:0051219	phosphoprotein binding
0.53	GO:0005102	receptor binding
0.38	GO:0097655	serpin family protein binding
0.34	GO:0005509	calcium ion binding
0.33	GO:0005198	structural molecule activity

0.65	GO:0005576	extracellular region
0.57	GO:0030141	secretory granule
0.57	GO:0045177	apical part of cell
0.55	GO:0009986	cell surface
0.35	GO:0045202	synapse
0.33	GO:0044175	host cell endosome membrane
0.33	GO:0036338	viral membrane
0.33	GO:0055036	virion membrane
0.30	GO:0016021	integral component of membrane

0.69

GO:0004252

sp|P00751|CFAB_HUMAN
Complement factor B
Search

CFB

0.95	Complement factor B

0.82	GO:0006956	complement activation
0.61	GO:0006508	proteolysis
0.54	GO:0002455	humoral immune response mediated by circulating immunoglobulin
0.46	GO:0045087	innate immune response
0.41	GO:2000427	positive regulation of apoptotic cell clearance
0.39	GO:0097066	response to thyroid hormone
0.38	GO:0032496	response to lipopolysaccharide
0.38	GO:0030449	regulation of complement activation
0.37	GO:0007584	response to nutrient
0.35	GO:0008283	cell proliferation

0.69	GO:0004252	serine-type endopeptidase activity
0.37	GO:0001848	complement binding
0.34	GO:0046872	metal ion binding
0.34	GO:0005044	scavenger receptor activity

0.65	GO:0005576	extracellular region
0.38	GO:0031982	vesicle
0.33	GO:0005886	plasma membrane

0.69

GO:0004252

sp|P00797|RENI_HUMAN
Renin
Search

REN

0.97	Renin-like aspartic protease

0.61	GO:0006508	proteolysis
0.60	GO:0002002	regulation of angiotensin levels in blood
0.59	GO:0002018	renin-angiotensin regulation of aldosterone production
0.58	GO:0042756	drinking behavior
0.55	GO:0001823	mesonephros development
0.54	GO:0008584	male gonad development
0.53	GO:0048469	cell maturation
0.53	GO:0042445	hormone metabolic process
0.52	GO:0043408	regulation of MAPK cascade
0.51	GO:0051604	protein maturation

0.70	GO:0070001	aspartic-type peptidase activity
0.65	GO:0004175	endopeptidase activity
0.49	GO:0005102	receptor binding
0.33	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity

0.53	GO:0045177	apical part of cell
0.50	GO:0005615	extracellular space
0.49	GO:0005764	lysosome
0.33	GO:0000324	fungal-type vacuole
0.33	GO:0005783	endoplasmic reticulum
0.33	GO:0005886	plasma membrane
0.32	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.32	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.33

EC:2.4.1.119

GO:0004579

sp|P00813|ADA_HUMAN
Adenosine deaminase
Search

ADA

0.51	Adenosine deaminase

0.65	GO:0009168	purine ribonucleoside monophosphate biosynthetic process
0.63	GO:0060169	negative regulation of adenosine receptor signaling pathway
0.61	GO:0046111	xanthine biosynthetic process
0.61	GO:0060407	negative regulation of penile erection
0.61	GO:0006157	deoxyadenosine catabolic process
0.60	GO:0006154	adenosine catabolic process
0.60	GO:0046103	inosine biosynthetic process
0.60	GO:0070256	negative regulation of mucus secretion
0.60	GO:0002636	positive regulation of germinal center formation
0.60	GO:0002314	germinal center B cell differentiation

0.72	GO:0019239	deaminase activity
0.61	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
0.47	GO:0008270	zinc ion binding
0.37	GO:0001883	purine nucleoside binding
0.35	GO:0005515	protein binding

0.56	GO:0009897	external side of plasma membrane
0.54	GO:0005764	lysosome
0.50	GO:0005829	cytosol
0.44	GO:0060205	cytoplasmic vesicle lumen
0.41	GO:0032839	dendrite cytoplasm
0.41	GO:0030054	cell junction
0.40	GO:0043025	neuronal cell body
0.38	GO:0005615	extracellular space

0.61

EC:3.5.4

GO:0016814

sp|P00846|ATP6_HUMAN
ATP synthase subunit a
Search

ATP6

0.43	ATP synthase subunit a

0.70	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.70	GO:0006754	ATP biosynthetic process
0.30	GO:0070482	response to oxygen levels
0.30	GO:0061024	membrane organization
0.30	GO:0007005	mitochondrion organization
0.30	GO:0007568	aging
0.30	GO:0046907	intracellular transport
0.30	GO:0006950	response to stress
0.30	GO:0006839	mitochondrial transport

0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.30	GO:0016887	ATPase activity

0.72	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)
0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane
0.30	GO:0005615	extracellular space
0.30	GO:0016021	integral component of membrane
0.30	GO:0043230	extracellular organelle
0.30	GO:0031982	vesicle
0.30	GO:0098798	mitochondrial protein complex

0.30

EC:3.6.1.3

GO:0016887

sp|P00915|CAH1_HUMAN
Carbonic anhydrase 1
Search

CA1

0.43	Erythrocyte carbonic anhydrase

0.72	GO:0006730	one-carbon metabolic process
0.51	GO:0038166	angiotensin-activated signaling pathway
0.50	GO:0044070	regulation of anion transport
0.50	GO:2000878	positive regulation of oligopeptide transport
0.50	GO:2001148	regulation of dipeptide transmembrane transport
0.49	GO:0015670	carbon dioxide transport
0.48	GO:0032849	positive regulation of cellular pH reduction
0.47	GO:0032230	positive regulation of synaptic transmission, GABAergic
0.46	GO:0034764	positive regulation of transmembrane transport
0.44	GO:0002009	morphogenesis of an epithelium

0.77	GO:0004089	carbonate dehydratase activity
0.63	GO:0008270	zinc ion binding
0.60	GO:0004064	arylesterase activity
0.35	GO:0016151	nickel cation binding
0.34	GO:0005515	protein binding

0.48	GO:0045177	apical part of cell
0.45	GO:0043209	myelin sheath
0.43	GO:0005737	cytoplasm
0.40	GO:0005886	plasma membrane
0.38	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.37	GO:0005902	microvillus
0.36	GO:0030424	axon
0.30	GO:0044425	membrane part

0.77

EC:4.2.1.1

GO:0004089

sp|P00918|CAH2_HUMAN
Carbonic anhydrase 2
Search

CA2

0.86	Carbonic anhydrase II

0.71	GO:0006730	one-carbon metabolic process
0.57	GO:0015670	carbon dioxide transport
0.56	GO:0038166	angiotensin-activated signaling pathway
0.56	GO:0044070	regulation of anion transport
0.56	GO:2000878	positive regulation of oligopeptide transport
0.56	GO:2001148	regulation of dipeptide transmembrane transport
0.54	GO:0032849	positive regulation of cellular pH reduction
0.53	GO:0032230	positive regulation of synaptic transmission, GABAergic
0.50	GO:0034764	positive regulation of transmembrane transport
0.48	GO:0002009	morphogenesis of an epithelium

0.77	GO:0004089	carbonate dehydratase activity
0.63	GO:0008270	zinc ion binding
0.55	GO:0004064	arylesterase activity
0.34	GO:0005515	protein binding

0.53	GO:0045177	apical part of cell
0.49	GO:0043209	myelin sheath
0.44	GO:0005829	cytosol
0.42	GO:0005886	plasma membrane
0.39	GO:0005902	microvillus
0.39	GO:0030424	axon
0.37	GO:0005615	extracellular space
0.36	GO:1903561	extracellular vesicle
0.32	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

0.77

EC:4.2.1.1

GO:0004089

sp|P00966|ASSY_HUMAN
Argininosuccinate synthase
Search

ASS1

0.46	Argininosuccinate synthetase

0.72	GO:0006526	arginine biosynthetic process
0.62	GO:0000053	argininosuccinate metabolic process
0.60	GO:0000050	urea cycle
0.56	GO:0071499	cellular response to laminar fluid shear stress
0.55	GO:0000052	citrulline metabolic process
0.54	GO:0045429	positive regulation of nitric oxide biosynthetic process
0.53	GO:1903038	negative regulation of leukocyte cell-cell adhesion
0.53	GO:0007623	circadian rhythm
0.52	GO:0006531	aspartate metabolic process
0.36	GO:0071418	cellular response to amine stimulus

0.80	GO:0004055	argininosuccinate synthase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0016597	amino acid binding
0.49	GO:0042802	identical protein binding
0.35	GO:0015643	toxic substance binding
0.34	GO:0003723	RNA binding

0.52	GO:0043209	myelin sheath
0.47	GO:0005829	cytosol
0.43	GO:0005739	mitochondrion
0.37	GO:0070062	extracellular exosome
0.36	GO:0070852	cell body fiber
0.35	GO:0043204	perikaryon
0.35	GO:0005764	lysosome
0.34	GO:0031968	organelle outer membrane
0.34	GO:0005783	endoplasmic reticulum
0.33	GO:0005634	nucleus

0.80

EC:6.3.4.5

GO:0004055

sp|P00973|OAS1_HUMAN
2'-5'-oligoadenylate synthase 1
Search

OAS1

0.97	Oligoadenylate synthetase 1

0.78	GO:0051607	defense response to virus
0.74	GO:0006955	immune response
0.58	GO:0045071	negative regulation of viral genome replication
0.48	GO:0060700	regulation of ribonuclease activity
0.48	GO:0042593	glucose homeostasis
0.45	GO:0035457	cellular response to interferon-alpha
0.45	GO:0006006	glucose metabolic process
0.43	GO:0006164	purine nucleotide biosynthetic process

0.77	GO:0003725	double-stranded RNA binding
0.63	GO:0016779	nucleotidyltransferase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0008270	zinc ion binding

0.44	GO:0005829	cytosol
0.39	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.63

EC:2.7.7

GO:0016779

sp|P00995|ISK1_HUMAN
Serine protease inhibitor Kazal-type 1
Search

SPINK1

0.85	Pancreatic secretory trypsin inhibitor

0.71	GO:0010951	negative regulation of endopeptidase activity
0.71	GO:1902572	negative regulation of serine-type peptidase activity
0.71	GO:1900003	regulation of serine-type endopeptidase activity
0.70	GO:0060046	regulation of acrosome reaction
0.68	GO:0010751	negative regulation of nitric oxide mediated signal transduction
0.65	GO:0090281	negative regulation of calcium ion import
0.65	GO:0048240	sperm capacitation
0.64	GO:2001256	regulation of store-operated calcium entry
0.64	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
0.46	GO:0043113	receptor clustering

0.74	GO:0004867	serine-type endopeptidase inhibitor activity
0.45	GO:0043236	laminin binding
0.45	GO:0005509	calcium ion binding
0.40	GO:0005044	scavenger receptor activity
0.37	GO:0008233	peptidase activity
0.37	GO:0099602	neurotransmitter receptor regulator activity
0.37	GO:0002162	dystroglycan binding
0.36	GO:0005539	glycosaminoglycan binding
0.36	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
0.36	GO:0033691	sialic acid binding

0.59	GO:0005615	extracellular space
0.55	GO:0001669	acrosomal vesicle
0.41	GO:1903561	extracellular vesicle
0.40	GO:0005605	basal lamina
0.37	GO:0005886	plasma membrane
0.37	GO:0045178	basal part of cell
0.37	GO:0031594	neuromuscular junction
0.36	GO:0030424	axon
0.35	GO:0005829	cytosol
0.35	GO:0098857	membrane microdomain

0.37

GO:0008233

sp|P01008|ANT3_HUMAN
Antithrombin-III
Search

SERPINC1

0.97	Serpin peptidase inhibitor clade C member 1

0.86	GO:2000266	regulation of blood coagulation, intrinsic pathway
0.74	GO:0010951	negative regulation of endopeptidase activity
0.45	GO:0071391	cellular response to estrogen stimulus
0.44	GO:0002438	acute inflammatory response to antigenic stimulus
0.44	GO:0007595	lactation
0.42	GO:0007584	response to nutrient
0.41	GO:0007596	blood coagulation
0.40	GO:0042129	regulation of T cell proliferation
0.38	GO:0010608	posttranscriptional regulation of gene expression
0.36	GO:0043687	post-translational protein modification

0.79	GO:0008201	heparin binding
0.77	GO:0004867	serine-type endopeptidase inhibitor activity
0.59	GO:0002020	protease binding
0.53	GO:0042802	identical protein binding
0.40	GO:0003730	mRNA 3'-UTR binding
0.34	GO:0046872	metal ion binding
0.34	GO:0035613	RNA stem-loop binding
0.33	GO:0016874	ligase activity

0.73	GO:0005615	extracellular space
0.38	GO:1903561	extracellular vesicle
0.36	GO:0060205	cytoplasmic vesicle lumen
0.36	GO:0005788	endoplasmic reticulum lumen
0.35	GO:0043025	neuronal cell body
0.35	GO:0030141	secretory granule
0.34	GO:0000932	P-body
0.34	GO:0010494	cytoplasmic stress granule
0.33	GO:0005886	plasma membrane

0.33

GO:0016874

sp|P01009|A1AT_HUMAN
Alpha-1-antitrypsin
Search

SERPINA1

0.87	Hibernation-specific plasma protein HP-55

0.58	GO:0010951	negative regulation of endopeptidase activity
0.46	GO:0006953	acute-phase response
0.40	GO:0034097	response to cytokine
0.40	GO:0043434	response to peptide hormone
0.37	GO:0032501	multicellular organismal process
0.36	GO:0002576	platelet degranulation
0.36	GO:0043312	neutrophil degranulation
0.36	GO:0006487	protein N-linked glycosylation
0.36	GO:0046687	response to chromate
0.36	GO:0033986	response to methanol

0.60	GO:0004867	serine-type endopeptidase inhibitor activity
0.53	GO:0002020	protease binding
0.49	GO:0042802	identical protein binding
0.36	GO:0008289	lipid binding
0.36	GO:0032190	acrosin binding
0.35	GO:0050997	quaternary ammonium group binding
0.35	GO:0070405	ammonium ion binding
0.34	GO:0033293	monocarboxylic acid binding
0.32	GO:0008233	peptidase activity
0.32	GO:0097159	organic cyclic compound binding

0.73	GO:0005615	extracellular space
0.48	GO:0005794	Golgi apparatus
0.47	GO:0005783	endoplasmic reticulum
0.38	GO:1903561	extracellular vesicle
0.38	GO:0031091	platelet alpha granule
0.36	GO:1904813	ficolin-1-rich granule lumen
0.36	GO:0034774	secretory granule lumen
0.36	GO:0097182	protein C inhibitor-coagulation factor Xa complex
0.36	GO:0097183	protein C inhibitor-coagulation factor XI complex
0.36	GO:0097181	protein C inhibitor-coagulation factor V complex

0.32

GO:0008233

sp|P01011|AACT_HUMAN
Alpha-1-antichymotrypsin
Search

SERPINA3

0.73	Serine protease inhibitor

0.54	GO:0010951	negative regulation of endopeptidase activity
0.41	GO:0043434	response to peptide hormone
0.40	GO:0034097	response to cytokine
0.39	GO:0006953	acute-phase response
0.39	GO:0008211	glucocorticoid metabolic process
0.39	GO:0006508	proteolysis
0.37	GO:0007283	spermatogenesis
0.37	GO:0006955	immune response
0.36	GO:0002576	platelet degranulation
0.36	GO:0030277	maintenance of gastrointestinal epithelium

0.56	GO:0004867	serine-type endopeptidase inhibitor activity
0.39	GO:0008233	peptidase activity
0.39	GO:0008289	lipid binding
0.38	GO:0032190	acrosin binding
0.38	GO:0050997	quaternary ammonium group binding
0.37	GO:0002020	protease binding
0.37	GO:0070405	ammonium ion binding
0.36	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.36	GO:0033293	monocarboxylic acid binding
0.34	GO:0008201	heparin binding

0.73	GO:0005615	extracellular space
0.44	GO:0030141	secretory granule
0.40	GO:1903561	extracellular vesicle
0.39	GO:0036030	protein C inhibitor-plasma kallikrein complex
0.39	GO:0097182	protein C inhibitor-coagulation factor Xa complex
0.39	GO:0097183	protein C inhibitor-coagulation factor XI complex
0.39	GO:0097181	protein C inhibitor-coagulation factor V complex
0.39	GO:0036029	protein C inhibitor-KLK3 complex
0.39	GO:0036028	protein C inhibitor-thrombin complex
0.39	GO:0036024	protein C inhibitor-TMPRSS7 complex

0.39

GO:0008233

sp|P01019|ANGT_HUMAN
Angiotensinogen
Search

AGT

0.97	Angiotensinogen

0.85	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin
0.66	GO:1903598	positive regulation of gap junction assembly
0.66	GO:0010536	positive regulation of activation of Janus kinase activity
0.66	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway
0.65	GO:0010873	positive regulation of cholesterol esterification
0.64	GO:1901201	regulation of extracellular matrix assembly
0.64	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
0.64	GO:1903779	regulation of cardiac conduction
0.63	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
0.62	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

0.69	GO:0031703	type 2 angiotensin receptor binding
0.67	GO:0031702	type 1 angiotensin receptor binding
0.46	GO:0004867	serine-type endopeptidase inhibitor activity
0.41	GO:0005179	hormone activity
0.38	GO:0016176	superoxide-generating NADPH oxidase activator activity
0.38	GO:0017080	sodium channel regulator activity
0.36	GO:0008083	growth factor activity

0.73	GO:0005615	extracellular space
0.39	GO:1903561	extracellular vesicle
0.35	GO:0005829	cytosol
0.33	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

sp|P01023|A2MG_HUMAN
Alpha-2-macroglobulin
Search

A2M

0.63	Alpha-macroglobulin

0.76	GO:0010951	negative regulation of endopeptidase activity
0.55	GO:0001869	negative regulation of complement activation, lectin pathway
0.42	GO:0007565	female pregnancy
0.41	GO:0048863	stem cell differentiation
0.38	GO:0007275	multicellular organism development
0.37	GO:0006953	acute-phase response
0.37	GO:0009611	response to wounding
0.36	GO:0002576	platelet degranulation
0.36	GO:0022617	extracellular matrix disassembly
0.36	GO:0002438	acute inflammatory response to antigenic stimulus

0.76	GO:0004866	endopeptidase inhibitor activity
0.55	GO:0043120	tumor necrosis factor binding
0.54	GO:0019959	interleukin-8 binding
0.53	GO:0019966	interleukin-1 binding
0.52	GO:0048306	calcium-dependent protein binding
0.51	GO:0002020	protease binding
0.46	GO:0005102	receptor binding
0.38	GO:0048403	brain-derived neurotrophic factor binding
0.38	GO:0048406	nerve growth factor binding
0.35	GO:0005096	GTPase activator activity

0.73	GO:0005615	extracellular space
0.39	GO:1903561	extracellular vesicle
0.37	GO:0031093	platelet alpha granule lumen
0.34	GO:0005829	cytosol
0.32	GO:0019866	organelle inner membrane
0.32	GO:0031966	mitochondrial membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P01024|CO3_HUMAN
Complement C3
Search

0.90	Epididymis secretory sperm binding protein Li 62p

0.84	GO:0006956	complement activation
0.74	GO:0010951	negative regulation of endopeptidase activity
0.66	GO:0006954	inflammatory response
0.59	GO:0001970	positive regulation of activation of membrane attack complex
0.59	GO:0002894	positive regulation of type II hypersensitivity
0.59	GO:0001796	regulation of type IIa hypersensitivity
0.58	GO:0010866	regulation of triglyceride biosynthetic process
0.58	GO:0097242	amyloid-beta clearance
0.57	GO:0010884	positive regulation of lipid storage
0.57	GO:2000427	positive regulation of apoptotic cell clearance

0.75	GO:0004866	endopeptidase inhibitor activity
0.61	GO:0031715	C5L2 anaphylatoxin chemotactic receptor binding
0.38	GO:0090729	toxin activity
0.36	GO:0005164	tumor necrosis factor receptor binding
0.36	GO:0004252	serine-type endopeptidase activity
0.34	GO:0008289	lipid binding
0.34	GO:0046872	metal ion binding
0.33	GO:0048037	cofactor binding
0.32	GO:0016491	oxidoreductase activity

0.73	GO:0005615	extracellular space
0.43	GO:0043234	protein complex
0.38	GO:1903561	extracellular vesicle
0.37	GO:0035578	azurophil granule lumen
0.36	GO:0005788	endoplasmic reticulum lumen
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.36

GO:0004252

sp|P01031|CO5_HUMAN
Complement C5
Search

0.97	Complement component 5

0.76	GO:0010951	negative regulation of endopeptidase activity
0.65	GO:0010760	negative regulation of macrophage chemotaxis
0.64	GO:0090197	positive regulation of chemokine secretion
0.63	GO:0006956	complement activation
0.63	GO:0010575	positive regulation of vascular endothelial growth factor production
0.60	GO:0006954	inflammatory response
0.59	GO:0045766	positive regulation of angiogenesis
0.57	GO:0001701	in utero embryonic development
0.40	GO:0016064	immunoglobulin mediated immune response
0.38	GO:0045087	innate immune response

0.76	GO:0004866	endopeptidase inhibitor activity
0.37	GO:0001664	G-protein coupled receptor binding
0.36	GO:0005125	cytokine activity
0.36	GO:0005126	cytokine receptor binding
0.34	GO:0001848	complement binding
0.33	GO:0001846	opsonin binding
0.33	GO:0003823	antigen binding
0.32	GO:0030246	carbohydrate binding
0.31	GO:0003924	GTPase activity
0.31	GO:0005525	GTP binding

0.71	GO:0005615	extracellular space
0.61	GO:0005579	membrane attack complex
0.37	GO:1903561	extracellular vesicle
0.33	GO:0030425	dendrite
0.33	GO:0030424	axon
0.33	GO:0045202	synapse
0.33	GO:0043025	neuronal cell body
0.32	GO:0030054	cell junction
0.32	GO:0045335	phagocytic vesicle
0.32	GO:0055037	recycling endosome

sp|P01033|TIMP1_HUMAN
Metalloproteinase inhibitor 1
Search

TIMP1

0.94	Tissue inhibitor of metalloproteinase 1

0.76	GO:0010951	negative regulation of endopeptidase activity
0.70	GO:2001044	regulation of integrin-mediated signaling pathway
0.70	GO:0051045	negative regulation of membrane protein ectodomain proteolysis
0.67	GO:1905049	negative regulation of metallopeptidase activity
0.66	GO:1901164	negative regulation of trophoblast cell migration
0.63	GO:0008284	positive regulation of cell proliferation
0.60	GO:0010469	regulation of receptor activity
0.51	GO:0034097	response to cytokine
0.49	GO:0009725	response to hormone
0.44	GO:0051216	cartilage development

0.85	GO:0008191	metalloendopeptidase inhibitor activity
0.64	GO:0005125	cytokine activity
0.54	GO:0002020	protease binding
0.51	GO:0008083	growth factor activity
0.49	GO:0008270	zinc ion binding
0.34	GO:0008237	metallopeptidase activity

0.66	GO:0005576	extracellular region
0.39	GO:0031093	platelet alpha granule lumen
0.38	GO:0005788	endoplasmic reticulum lumen
0.37	GO:0005581	collagen trimer

sp|P01034|CYTC_HUMAN
Cystatin-C
Search

CST3

0.75	Cystatin-C

0.76	GO:0010951	negative regulation of endopeptidase activity
0.62	GO:0010711	negative regulation of collagen catabolic process
0.62	GO:0060311	negative regulation of elastin catabolic process
0.60	GO:0060313	negative regulation of blood vessel remodeling
0.60	GO:0010716	negative regulation of extracellular matrix disassembly
0.52	GO:2000116	regulation of cysteine-type endopeptidase activity
0.51	GO:0097435	supramolecular fiber organization
0.50	GO:0006952	defense response
0.48	GO:0042747	circadian sleep/wake cycle, REM sleep
0.46	GO:0060009	Sertoli cell development

0.83	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.62	GO:0002020	protease binding
0.56	GO:0001540	amyloid-beta binding
0.50	GO:0042802	identical protein binding
0.33	GO:0008234	cysteine-type peptidase activity

0.56	GO:0005615	extracellular space
0.45	GO:0005771	multivesicular body
0.44	GO:0005604	basement membrane
0.43	GO:0043025	neuronal cell body
0.43	GO:0043292	contractile fiber
0.43	GO:0030424	axon
0.43	GO:0031965	nuclear membrane
0.43	GO:0048471	perinuclear region of cytoplasm
0.43	GO:0005764	lysosome
0.41	GO:1903561	extracellular vesicle

0.33

GO:0008234

sp|P01036|CYTS_HUMAN
Cystatin-S
Search

0.71	Cystatin-SN

0.76	GO:0010951	negative regulation of endopeptidase activity
0.56	GO:2000116	regulation of cysteine-type endopeptidase activity
0.51	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
0.40	GO:0001895	retina homeostasis
0.39	GO:0010711	negative regulation of collagen catabolic process
0.39	GO:0060311	negative regulation of elastin catabolic process
0.38	GO:0060313	negative regulation of blood vessel remodeling
0.38	GO:0010716	negative regulation of extracellular matrix disassembly
0.36	GO:0097435	supramolecular fiber organization
0.36	GO:0006952	defense response

0.83	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.58	GO:0002020	protease binding
0.37	GO:0001540	amyloid-beta binding
0.36	GO:0042802	identical protein binding

0.55	GO:0005615	extracellular space
0.41	GO:1903561	extracellular vesicle
0.30	GO:0016020	membrane

sp|P01037|CYTN_HUMAN
Cystatin-SN
Search

0.72	Cystatin-SN

0.76	GO:0010951	negative regulation of endopeptidase activity
0.56	GO:2000116	regulation of cysteine-type endopeptidase activity
0.51	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
0.39	GO:0001895	retina homeostasis
0.39	GO:0010711	negative regulation of collagen catabolic process
0.39	GO:0060311	negative regulation of elastin catabolic process
0.38	GO:0060313	negative regulation of blood vessel remodeling
0.38	GO:0010716	negative regulation of extracellular matrix disassembly
0.36	GO:0097435	supramolecular fiber organization
0.36	GO:0006952	defense response

0.83	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.58	GO:0002020	protease binding
0.37	GO:0001540	amyloid-beta binding
0.36	GO:0042802	identical protein binding

0.55	GO:0005615	extracellular space
0.41	GO:1903561	extracellular vesicle
0.30	GO:0016020	membrane

sp|P01040|CYTA_HUMAN
Cystatin-A
Search

CSTA

0.91	Leukocyte cysteine proteinase inhibitor 1

0.76	GO:0010951	negative regulation of endopeptidase activity
0.60	GO:0030216	keratinocyte differentiation
0.59	GO:0018149	peptide cross-linking
0.55	GO:0098609	cell-cell adhesion
0.36	GO:0012501	programmed cell death
0.34	GO:0006972	hyperosmotic response
0.33	GO:0006508	proteolysis
0.32	GO:0006281	DNA repair
0.32	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.83	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.60	GO:0002020	protease binding
0.58	GO:0030674	protein binding, bridging
0.48	GO:0005198	structural molecule activity
0.33	GO:0008234	cysteine-type peptidase activity
0.32	GO:0004518	nuclease activity

0.62	GO:0001533	cornified envelope
0.54	GO:0005615	extracellular space
0.51	GO:0005829	cytosol
0.47	GO:0005634	nucleus
0.39	GO:0031012	extracellular matrix
0.38	GO:1903561	extracellular vesicle

0.33

GO:0008234

sp|P01042|KNG1_HUMAN
Kininogen-1
Search

KNG1

0.94	High molecular weight kininogen II

0.76	GO:0010951	negative regulation of endopeptidase activity
0.64	GO:0030195	negative regulation of blood coagulation
0.61	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.57	GO:0007162	negative regulation of cell adhesion
0.47	GO:0042311	vasodilation
0.45	GO:0006954	inflammatory response
0.43	GO:0007596	blood coagulation
0.40	GO:0072376	protein activation cascade
0.39	GO:0002576	platelet degranulation
0.39	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide

0.82	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.54	GO:0005102	receptor binding
0.38	GO:0008201	heparin binding
0.36	GO:0002020	protease binding
0.35	GO:0008270	zinc ion binding
0.32	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.32	GO:0051537	2 iron, 2 sulfur cluster binding
0.31	GO:0043565	sequence-specific DNA binding
0.31	GO:0009055	electron transfer activity

0.57	GO:0005615	extracellular space
0.55	GO:0031012	extracellular matrix
0.40	GO:0031093	platelet alpha granule lumen
0.39	GO:1903561	extracellular vesicle
0.38	GO:0005788	endoplasmic reticulum lumen
0.36	GO:0043204	perikaryon
0.34	GO:0005886	plasma membrane
0.31	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

sp|P01100|FOS_HUMAN
Proto-oncogene c-Fos
Search

FOS

0.96	Proto-oncogene protein c-fos

0.71	GO:0006357	regulation of transcription by RNA polymerase II
0.62	GO:0035994	response to muscle stretch
0.62	GO:0045672	positive regulation of osteoclast differentiation
0.61	GO:0071277	cellular response to calcium ion
0.60	GO:0035914	skeletal muscle cell differentiation
0.60	GO:0071276	cellular response to cadmium ion
0.60	GO:0060395	SMAD protein signal transduction
0.58	GO:0007179	transforming growth factor beta receptor signaling pathway
0.55	GO:0006366	transcription by RNA polymerase II
0.54	GO:0034614	cellular response to reactive oxygen species

0.61	GO:0070412	R-SMAD binding
0.61	GO:0003700	DNA binding transcription factor activity
0.60	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
0.60	GO:0001102	RNA polymerase II activating transcription factor binding
0.60	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.57	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.55	GO:0003682	chromatin binding
0.54	GO:0046982	protein heterodimerization activity
0.33	GO:0005198	structural molecule activity

0.74	GO:0005667	transcription factor complex
0.52	GO:0032993	protein-DNA complex
0.52	GO:0005654	nucleoplasm
0.43	GO:0005783	endoplasmic reticulum
0.42	GO:0005829	cytosol
0.39	GO:0043005	neuron projection
0.35	GO:0042025	host cell nucleus
0.33	GO:0019028	viral capsid
0.30	GO:0016020	membrane

sp|P01106|MYC_HUMAN
Myc proto-oncogene protein
Search

MYC

0.93	MYC proto-oncogene, bHLH transcription factor

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0045656	negative regulation of monocyte differentiation
0.55	GO:0048146	positive regulation of fibroblast proliferation
0.54	GO:0010332	response to gamma radiation
0.53	GO:0060070	canonical Wnt signaling pathway
0.53	GO:2001022	positive regulation of response to DNA damage stimulus
0.53	GO:0032204	regulation of telomere maintenance
0.53	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

0.61	GO:0003700	DNA binding transcription factor activity
0.59	GO:0046983	protein dimerization activity
0.55	GO:0070888	E-box binding
0.49	GO:0032403	protein complex binding
0.39	GO:0070491	repressing transcription factor binding
0.38	GO:0033613	activating transcription factor binding
0.38	GO:0071074	eukaryotic initiation factor eIF2 binding
0.36	GO:0031625	ubiquitin protein ligase binding
0.36	GO:0003729	mRNA binding

0.61	GO:0005634	nucleus
0.51	GO:0070013	intracellular organelle lumen
0.45	GO:0044446	intracellular organelle part
0.42	GO:0043232	intracellular non-membrane-bounded organelle
0.37	GO:0005791	rough endoplasmic reticulum
0.36	GO:0030424	axon
0.36	GO:0042025	host cell nucleus
0.36	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0005739	mitochondrion
0.35	GO:0043234	protein complex

sp|P01111|RASN_HUMAN
GTPase NRas
Search

NRAS

0.84	NRAS proto-oncogene, GTPase

0.61	GO:0007165	signal transduction
0.52	GO:0008284	positive regulation of cell proliferation
0.50	GO:0001936	regulation of endothelial cell proliferation
0.45	GO:0038002	endocrine signaling
0.44	GO:0021897	forebrain astrocyte development
0.44	GO:0035022	positive regulation of Rac protein signal transduction
0.44	GO:0048169	regulation of long-term neuronal synaptic plasticity
0.43	GO:0060441	epithelial tube branching involved in lung morphogenesis
0.43	GO:0048873	homeostasis of number of cells within a tissue
0.43	GO:0032228	regulation of synaptic transmission, GABAergic

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.49	GO:0032403	protein complex binding
0.36	GO:0003876	AMP deaminase activity
0.34	GO:0019003	GDP binding
0.34	GO:0008022	protein C-terminus binding
0.33	GO:0003677	DNA binding
0.32	GO:0046872	metal ion binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0008144	drug binding

0.47	GO:0005794	Golgi apparatus
0.42	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.39	GO:0098588	bounding membrane of organelle
0.38	GO:0031984	organelle subcompartment
0.36	GO:0070062	extracellular exosome
0.35	GO:0070820	tertiary granule
0.34	GO:0030659	cytoplasmic vesicle membrane
0.33	GO:0098805	whole membrane

0.36

EC:3.5.4.6

GO:0003876

sp|P01112|RASH_HUMAN
GTPase HRas
Search

HRAS

0.53	V-Ha-ras Harvey rat sarcoma viral oncogene homolog a

0.61	GO:0007165	signal transduction
0.55	GO:0048169	regulation of long-term neuronal synaptic plasticity
0.53	GO:2000630	positive regulation of miRNA metabolic process
0.53	GO:0043524	negative regulation of neuron apoptotic process
0.52	GO:1900029	positive regulation of ruffle assembly
0.52	GO:0008284	positive regulation of cell proliferation
0.52	GO:0090398	cellular senescence
0.52	GO:2000251	positive regulation of actin cytoskeleton reorganization
0.51	GO:0071480	cellular response to gamma radiation
0.51	GO:0001934	positive regulation of protein phosphorylation

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.51	GO:0019003	GDP binding
0.50	GO:0008022	protein C-terminus binding
0.41	GO:0032403	protein complex binding
0.37	GO:0019002	GMP binding
0.36	GO:0030275	LRR domain binding
0.33	GO:0042802	identical protein binding
0.33	GO:0005198	structural molecule activity
0.32	GO:0030554	adenyl nucleotide binding

0.46	GO:0005794	Golgi apparatus
0.42	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.36	GO:0098588	bounding membrane of organelle
0.36	GO:0031984	organelle subcompartment
0.36	GO:0020002	host cell plasma membrane
0.35	GO:0098857	membrane microdomain
0.34	GO:0005829	cytosol
0.34	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0005925	focal adhesion
0.33	GO:0005739	mitochondrion

sp|P01116|RASK_HUMAN
GTPase KRas
Search

KRAS

0.91	KRAS proto-oncogene, GTPase

0.61	GO:0007165	signal transduction
0.56	GO:0038002	endocrine signaling
0.55	GO:0021897	forebrain astrocyte development
0.54	GO:0035022	positive regulation of Rac protein signal transduction
0.53	GO:0048169	regulation of long-term neuronal synaptic plasticity
0.53	GO:0060441	epithelial tube branching involved in lung morphogenesis
0.53	GO:0008284	positive regulation of cell proliferation
0.52	GO:0048873	homeostasis of number of cells within a tissue
0.52	GO:0032228	regulation of synaptic transmission, GABAergic
0.52	GO:0008542	visual learning

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.49	GO:0032403	protein complex binding
0.41	GO:0019002	GMP binding
0.40	GO:0030275	LRR domain binding
0.40	GO:0019003	GDP binding
0.36	GO:0042802	identical protein binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0003677	DNA binding

0.51	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.40	GO:0005737	cytoplasm
0.39	GO:0098857	membrane microdomain
0.37	GO:0012505	endomembrane system
0.36	GO:0043231	intracellular membrane-bounded organelle
0.36	GO:0098588	bounding membrane of organelle
0.36	GO:0005925	focal adhesion
0.36	GO:0031984	organelle subcompartment
0.35	GO:0070062	extracellular exosome
0.34	GO:0012506	vesicle membrane

sp|P01127|PDGFB_HUMAN
Platelet-derived growth factor subunit B
Search

PDGFB

0.97	Platelet-derived growth factor subunit B

0.75	GO:0010469	regulation of receptor activity
0.66	GO:0072126	positive regulation of glomerular mesangial cell proliferation
0.65	GO:2000591	positive regulation of metanephric mesenchymal cell migration
0.65	GO:1900238	regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
0.65	GO:1900127	positive regulation of hyaluronan biosynthetic process
0.65	GO:1905176	positive regulation of vascular smooth muscle cell dedifferentiation
0.64	GO:1905064	negative regulation of vascular smooth muscle cell differentiation
0.64	GO:0010512	negative regulation of phosphatidylinositol biosynthetic process
0.63	GO:0010544	negative regulation of platelet activation
0.63	GO:0031954	positive regulation of protein autophosphorylation

0.78	GO:0008083	growth factor activity
0.63	GO:0005161	platelet-derived growth factor receptor binding
0.63	GO:0016176	superoxide-generating NADPH oxidase activator activity
0.62	GO:0048407	platelet-derived growth factor binding
0.61	GO:0042056	chemoattractant activity
0.58	GO:0005518	collagen binding
0.55	GO:0042803	protein homodimerization activity
0.53	GO:0046982	protein heterodimerization activity
0.36	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.35	GO:0005088	Ras guanyl-nucleotide exchange factor activity

0.55	GO:0009986	cell surface
0.45	GO:0005615	extracellular space
0.42	GO:0016323	basolateral plasma membrane
0.38	GO:0005622	intracellular
0.38	GO:0031012	extracellular matrix
0.36	GO:0031983	vesicle lumen
0.35	GO:0043025	neuronal cell body
0.35	GO:0030425	dendrite
0.34	GO:0098588	bounding membrane of organelle
0.34	GO:0012505	endomembrane system

0.36	EC:2.7.1.153	GO:0046934
0.36	KEGG:R04545	GO:0046934

sp|P01130|LDLR_HUMAN
Low-density lipoprotein receptor
Search

LDLR

0.80	Low density lipoprotein receptor a

0.58	GO:0090118	receptor-mediated endocytosis involved in cholesterol transport
0.57	GO:0061889	negative regulation of astrocyte activation
0.56	GO:0061771	response to caloric restriction
0.56	GO:1903979	negative regulation of microglial cell activation
0.56	GO:0030299	intestinal cholesterol absorption
0.56	GO:0070508	cholesterol import
0.56	GO:1905167	positive regulation of lysosomal protein catabolic process
0.56	GO:0010899	regulation of phosphatidylcholine catabolic process
0.55	GO:0008203	cholesterol metabolic process
0.55	GO:0034383	low-density lipoprotein particle clearance

0.70	GO:0005509	calcium ion binding
0.58	GO:0005041	low-density lipoprotein receptor activity
0.56	GO:0030229	very-low-density lipoprotein particle receptor activity
0.55	GO:0030169	low-density lipoprotein particle binding
0.52	GO:0001540	amyloid-beta binding
0.52	GO:0002020	protease binding
0.48	GO:0042802	identical protein binding
0.37	GO:0038025	reelin receptor activity
0.37	GO:0034185	apolipoprotein binding
0.36	GO:0048306	calcium-dependent protein binding

0.56	GO:1990666	PCSK9-LDLR complex
0.55	GO:0005905	clathrin-coated pit
0.55	GO:0097443	sorting endosome
0.54	GO:0005770	late endosome
0.54	GO:0005769	early endosome
0.53	GO:0005764	lysosome
0.52	GO:0009986	cell surface
0.51	GO:0005615	extracellular space
0.51	GO:0016323	basolateral plasma membrane
0.51	GO:0043235	receptor complex

sp|P01133|EGF_HUMAN
Pro-epidermal growth factor
Search

EGF

0.97	Pro-epidermal growth factor

0.74	GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification
0.68	GO:0060070	canonical Wnt signaling pathway
0.63	GO:0010469	regulation of receptor activity
0.63	GO:0007262	STAT protein import into nucleus
0.61	GO:1900127	positive regulation of hyaluronan biosynthetic process
0.60	GO:0090370	negative regulation of cholesterol efflux
0.60	GO:0035413	positive regulation of catenin import into nucleus
0.59	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation
0.59	GO:0043388	positive regulation of DNA binding
0.59	GO:0070371	ERK1 and ERK2 cascade

0.70	GO:0017147	Wnt-protein binding
0.69	GO:0005509	calcium ion binding
0.69	GO:0042813	Wnt-activated receptor activity
0.66	GO:0008083	growth factor activity
0.58	GO:0005154	epidermal growth factor receptor binding
0.39	GO:0004713	protein tyrosine kinase activity
0.38	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
0.38	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.36	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.33	GO:0005201	extracellular matrix structural constituent

0.64	GO:0043235	receptor complex
0.55	GO:0070062	extracellular exosome
0.44	GO:0005886	plasma membrane
0.38	GO:0005765	lysosomal membrane
0.38	GO:0031093	platelet alpha granule lumen
0.37	GO:0030665	clathrin-coated vesicle membrane
0.35	GO:0005794	Golgi apparatus
0.33	GO:0031429	box H/ACA snoRNP complex
0.33	GO:0005578	proteinaceous extracellular matrix
0.32	GO:0043679	axon terminus

0.39	EC:2.7.10	GO:0004713
0.38	KEGG:R04545	GO:0046934

sp|P01135|TGFA_HUMAN
Protransforming growth factor alpha
Search

TGFA

0.97	Protransforming growth factor alpha

0.61	GO:0072574	hepatocyte proliferation
0.61	GO:0007173	epidermal growth factor receptor signaling pathway
0.58	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
0.58	GO:0061377	mammary gland lobule development
0.58	GO:0008284	positive regulation of cell proliferation
0.55	GO:0001525	angiogenesis
0.50	GO:0000187	activation of MAPK activity
0.47	GO:0010469	regulation of receptor activity
0.45	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
0.45	GO:0051781	positive regulation of cell division

0.63	GO:0005154	epidermal growth factor receptor binding
0.48	GO:0008083	growth factor activity

0.47	GO:0005615	extracellular space
0.43	GO:0005887	integral component of plasma membrane
0.40	GO:0016323	basolateral plasma membrane
0.40	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0009986	cell surface
0.38	GO:0031410	cytoplasmic vesicle
0.37	GO:0005634	nucleus
0.37	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
0.35	GO:0012506	vesicle membrane
0.35	GO:0000139	Golgi membrane

sp|P01137|TGFB1_HUMAN
Transforming growth factor beta-1
Search

TGFB1

0.92	Transforming growth factor beta

0.79	GO:0016049	cell growth
0.77	GO:1900126	negative regulation of hyaluronan biosynthetic process
0.76	GO:1901664	regulation of NAD+ ADP-ribosyltransferase activity
0.76	GO:0043932	ossification involved in bone remodeling
0.75	GO:0048298	positive regulation of isotype switching to IgA isotypes
0.75	GO:0007182	common-partner SMAD protein phosphorylation
0.75	GO:0010936	negative regulation of macrophage cytokine production
0.75	GO:0007183	SMAD protein complex assembly
0.75	GO:0010763	positive regulation of fibroblast migration
0.74	GO:0032740	positive regulation of interleukin-17 production

0.84	GO:0005160	transforming growth factor beta receptor binding
0.75	GO:0008083	growth factor activity
0.71	GO:0003823	antigen binding
0.58	GO:0043539	protein serine/threonine kinase activator activity
0.53	GO:0042802	identical protein binding
0.51	GO:0019899	enzyme binding
0.48	GO:0005125	cytokine activity
0.41	GO:0047485	protein N-terminus binding
0.39	GO:0046982	protein heterodimerization activity
0.34	GO:0050431	transforming growth factor beta binding

0.72	GO:0005615	extracellular space
0.63	GO:0009986	cell surface
0.61	GO:0005902	microvillus
0.56	GO:0005578	proteinaceous extracellular matrix
0.53	GO:0005634	nucleus
0.44	GO:0005737	cytoplasm
0.40	GO:0043025	neuronal cell body
0.40	GO:0030424	axon
0.38	GO:0097708	intracellular vesicle
0.37	GO:0012505	endomembrane system

sp|P01138|NGF_HUMAN
Beta-nerve growth factor
Search

NGF

0.76	Beta-nerve growth factor

0.75	GO:0010469	regulation of receptor activity
0.52	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
0.50	GO:0010951	negative regulation of endopeptidase activity
0.50	GO:0048812	neuron projection morphogenesis
0.46	GO:0010628	positive regulation of gene expression
0.45	GO:0043524	negative regulation of neuron apoptotic process
0.44	GO:0045664	regulation of neuron differentiation
0.44	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.42	GO:0007267	cell-cell signaling
0.38	GO:0038179	neurotrophin signaling pathway

0.78	GO:0008083	growth factor activity
0.57	GO:0005163	nerve growth factor receptor binding
0.54	GO:0008191	metalloendopeptidase inhibitor activity
0.37	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
0.36	GO:0038177	death receptor agonist activity
0.36	GO:0005057	signal transducer activity, downstream of receptor
0.36	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
0.33	GO:0042802	identical protein binding

0.42	GO:0005576	extracellular region
0.42	GO:0031410	cytoplasmic vesicle
0.37	GO:0005796	Golgi lumen
0.36	GO:0005788	endoplasmic reticulum lumen
0.35	GO:0044306	neuron projection terminus
0.30	GO:0016020	membrane

sp|P01148|GON1_HUMAN
Progonadoliberin-1
Search

GNRH1

0.91	Chicken-I-type gonadotropin-releasing hormone

0.76	GO:0010469	regulation of receptor activity
0.71	GO:2000354	regulation of ovarian follicle development
0.70	GO:2001223	negative regulation of neuron migration
0.66	GO:0045471	response to ethanol
0.62	GO:0048545	response to steroid hormone
0.47	GO:0060255	regulation of macromolecule metabolic process
0.46	GO:1990637	response to prolactin
0.45	GO:0044849	estrous cycle
0.45	GO:0033087	negative regulation of immature T cell proliferation
0.45	GO:0035864	response to potassium ion

0.87

GO:0005183

gonadotropin hormone-releasing hormone activity

0.66	GO:0005576	extracellular region
0.47	GO:1990008	neurosecretory vesicle
0.45	GO:0098556	cytoplasmic side of rough endoplasmic reticulum membrane
0.44	GO:0043204	perikaryon
0.43	GO:0043679	axon terminus
0.42	GO:0030425	dendrite
0.41	GO:0005798	Golgi-associated vesicle
0.38	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

sp|P01160|ANF_HUMAN
Natriuretic peptides A
Search

NPPA

0.97	Atrial natriuretic peptide hormone

0.77	GO:0050880	regulation of blood vessel size
0.76	GO:0010469	regulation of receptor activity
0.67	GO:0007168	receptor guanylyl cyclase signaling pathway
0.67	GO:1903766	positive regulation of potassium ion export across plasma membrane
0.65	GO:1902261	positive regulation of delayed rectifier potassium channel activity
0.65	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization
0.64	GO:0060452	positive regulation of cardiac muscle contraction
0.63	GO:0010460	positive regulation of heart rate
0.62	GO:0006182	cGMP biosynthetic process
0.62	GO:0007565	female pregnancy

0.79	GO:0005179	hormone activity
0.62	GO:0071855	neuropeptide receptor binding
0.59	GO:0051427	hormone receptor binding

0.66	GO:0005576	extracellular region
0.46	GO:0043234	protein complex
0.42	GO:0042629	mast cell granule
0.40	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|P01178|NEU1_HUMAN
Oxytocin-neurophysin 1
Search

OXT

0.96	Prepropeptide for oxytocin and neurophysin

0.76	GO:0010469	regulation of receptor activity
0.51	GO:0032094	response to food
0.49	GO:0070528	protein kinase C signaling
0.49	GO:0090201	negative regulation of release of cytochrome c from mitochondria
0.49	GO:0070371	ERK1 and ERK2 cascade
0.48	GO:0009612	response to mechanical stimulus
0.48	GO:0033138	positive regulation of peptidyl-serine phosphorylation
0.48	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.45	GO:0002125	maternal aggressive behavior
0.45	GO:0006915	apoptotic process

0.86	GO:0005185	neurohypophyseal hormone activity
0.52	GO:0031894	V1A vasopressin receptor binding
0.49	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.44	GO:0031855	oxytocin receptor binding
0.41	GO:0004871	signal transducer activity
0.41	GO:0004672	protein kinase activity
0.40	GO:0031895	V1B vasopressin receptor binding
0.36	GO:0031896	V2 vasopressin receptor binding
0.33	GO:0004842	ubiquitin-protein transferase activity

0.66	GO:0005576	extracellular region
0.42	GO:0030141	secretory granule
0.42	GO:0043005	neuron projection
0.41	GO:0120038	plasma membrane bounded cell projection part
0.40	GO:0098793	presynapse
0.38	GO:0036477	somatodendritic compartment
0.34	GO:0030665	clathrin-coated vesicle membrane
0.34	GO:0044297	cell body
0.33	GO:0005829	cytosol
0.30	GO:0044425	membrane part

0.33

GO:0004842

sp|P01185|NEU2_HUMAN
Vasopressin-neurophysin 2-copeptin
Search

0.95	Prepropeptide for oxytocin and neurophysin

0.76	GO:0010469	regulation of receptor activity
0.53	GO:0070528	protein kinase C signaling
0.53	GO:0090201	negative regulation of release of cytochrome c from mitochondria
0.52	GO:0070371	ERK1 and ERK2 cascade
0.51	GO:0033138	positive regulation of peptidyl-serine phosphorylation
0.51	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.48	GO:0032094	response to food
0.48	GO:0006915	apoptotic process
0.46	GO:0010628	positive regulation of gene expression
0.46	GO:0009612	response to mechanical stimulus

0.86	GO:0005185	neurohypophyseal hormone activity
0.56	GO:0031894	V1A vasopressin receptor binding
0.52	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.43	GO:0004871	signal transducer activity
0.43	GO:0004672	protein kinase activity
0.42	GO:0031855	oxytocin receptor binding
0.41	GO:0031895	V1B vasopressin receptor binding
0.36	GO:0031896	V2 vasopressin receptor binding
0.33	GO:0004842	ubiquitin-protein transferase activity
0.33	GO:0052795	exo-alpha-(2->6)-sialidase activity

0.66	GO:0005576	extracellular region
0.43	GO:0043005	neuron projection
0.43	GO:0120038	plasma membrane bounded cell projection part
0.41	GO:0036477	somatodendritic compartment
0.41	GO:0030141	secretory granule
0.39	GO:0044297	cell body
0.38	GO:0098793	presynapse
0.35	GO:0030665	clathrin-coated vesicle membrane
0.34	GO:0005829	cytosol
0.30	GO:0044425	membrane part

0.33	EC:3.2.1.18	GO:0052795
0.33	KEGG:R03876	GO:0004842

sp|P01189|COLI_HUMAN
Pro-opiomelanocortin
Search

POMC

0.59	Proopiomelanocortin (Adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)

0.75	GO:0010469	regulation of receptor activity
0.56	GO:2000852	regulation of corticosterone secretion
0.53	GO:0032098	regulation of appetite
0.53	GO:0032720	negative regulation of tumor necrosis factor production
0.52	GO:0070873	regulation of glycogen metabolic process
0.52	GO:0033059	cellular pigmentation
0.51	GO:0008217	regulation of blood pressure
0.50	GO:0042593	glucose homeostasis
0.48	GO:0007267	cell-cell signaling
0.48	GO:0045944	positive regulation of transcription by RNA polymerase II

0.79	GO:0005179	hormone activity
0.55	GO:0070996	type 1 melanocortin receptor binding
0.55	GO:0031781	type 3 melanocortin receptor binding
0.55	GO:0031782	type 4 melanocortin receptor binding
0.32	GO:0009008	DNA-methyltransferase activity
0.32	GO:0008270	zinc ion binding

0.66	GO:0005576	extracellular region
0.51	GO:0030141	secretory granule
0.36	GO:0060205	cytoplasmic vesicle lumen
0.36	GO:0031907	microbody lumen
0.35	GO:0044439	peroxisomal part

0.32

GO:0009008

sp|P01210|PENK_HUMAN
Proenkephalin-A
Search

PENK

0.97	Proenkephalin-A-A

0.80	GO:0007218	neuropeptide signaling pathway
0.64	GO:0002118	aggressive behavior
0.63	GO:0010469	regulation of receptor activity
0.63	GO:0001964	startle response
0.63	GO:0001662	behavioral fear response
0.61	GO:0019233	sensory perception of pain
0.59	GO:0007626	locomotory behavior
0.46	GO:0007268	chemical synaptic transmission
0.43	GO:0051867	general adaptation syndrome, behavioral process
0.43	GO:2000987	positive regulation of behavioral fear response

0.74	GO:0001515	opioid peptide activity
0.51	GO:0031628	opioid receptor binding
0.48	GO:0005184	neuropeptide hormone activity
0.35	GO:0016849	phosphorus-oxygen lyase activity
0.32	GO:0090729	toxin activity

0.56	GO:0005576	extracellular region
0.49	GO:0043679	axon terminus
0.48	GO:0043025	neuronal cell body
0.48	GO:0030425	dendrite
0.43	GO:0032280	symmetric synapse
0.42	GO:0070852	cell body fiber
0.40	GO:0030424	axon
0.39	GO:0005886	plasma membrane
0.36	GO:0005788	endoplasmic reticulum lumen
0.30	GO:0031224	intrinsic component of membrane

0.35

EC:4.6

GO:0016849

sp|P01213|PDYN_HUMAN
Proenkephalin-B
Search

PDYN

0.95	Beta-neoendorphin-dynorphin

0.80	GO:0007218	neuropeptide signaling pathway
0.61	GO:0010469	regulation of receptor activity
0.48	GO:0098916	anterograde trans-synaptic signaling
0.46	GO:0007600	sensory perception
0.36	GO:0046928	regulation of neurotransmitter secretion

0.71	GO:0001515	opioid peptide activity
0.53	GO:0031628	opioid receptor binding
0.50	GO:0005184	neuropeptide hormone activity

0.54	GO:0005576	extracellular region
0.50	GO:0043679	axon terminus
0.48	GO:0043025	neuronal cell body
0.48	GO:0030425	dendrite
0.45	GO:0005886	plasma membrane
0.32	GO:0005737	cytoplasm

sp|P01215|GLHA_HUMAN
Glycoprotein hormones alpha chain
Search

CGA

0.93	Glycoprotein hormones alpha chain

0.76	GO:0010469	regulation of receptor activity
0.52	GO:0046884	follicle-stimulating hormone secretion
0.52	GO:0032275	luteinizing hormone secretion
0.51	GO:0006590	thyroid hormone generation
0.50	GO:0030878	thyroid gland development
0.50	GO:0046621	negative regulation of organ growth
0.48	GO:0008406	gonad development
0.47	GO:0048589	developmental growth
0.46	GO:0032870	cellular response to hormone stimulus
0.35	GO:0016486	peptide hormone processing

0.79	GO:0005179	hormone activity
0.44	GO:0046982	protein heterodimerization activity
0.36	GO:0008083	growth factor activity

0.66	GO:0005576	extracellular region
0.35	GO:0005796	Golgi lumen
0.30	GO:0031224	intrinsic component of membrane

sp|P01222|TSHB_HUMAN
Thyrotropin subunit beta
Search

TSHB

0.83	Thyroid stimulating hormone beta subunit

0.76	GO:0010469	regulation of receptor activity
0.40	GO:0010033	response to organic substance
0.39	GO:0071495	cellular response to endogenous stimulus
0.39	GO:0007267	cell-cell signaling
0.38	GO:0007186	G-protein coupled receptor signaling pathway
0.38	GO:0033273	response to vitamin
0.37	GO:0043627	response to estrogen
0.37	GO:0070887	cellular response to chemical stimulus
0.37	GO:0051592	response to calcium ion

0.79

GO:0005179

hormone activity

0.66	GO:0005576	extracellular region
0.34	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|P01225|FSHB_HUMAN
Follitropin subunit beta
Search

FSHB

0.95	Follicle stimulating hormone beta subunit

0.76	GO:0010469	regulation of receptor activity
0.59	GO:0042699	follicle-stimulating hormone signaling pathway
0.58	GO:0060011	Sertoli cell proliferation
0.57	GO:0007179	transforming growth factor beta receptor signaling pathway
0.57	GO:0046852	positive regulation of bone remodeling
0.56	GO:0045124	regulation of bone resorption
0.55	GO:0045670	regulation of osteoclast differentiation
0.54	GO:0032846	positive regulation of homeostatic process
0.49	GO:0010628	positive regulation of gene expression
0.45	GO:0007267	cell-cell signaling

0.79

GO:0005179

hormone activity

0.66	GO:0005576	extracellular region
0.41	GO:0005737	cytoplasm
0.35	GO:0031982	vesicle
0.33	GO:0043234	protein complex
0.30	GO:0016020	membrane

sp|P01229|LSHB_HUMAN
Lutropin subunit beta
Search

0.95	Chorionic gonadotropin beta subunit

0.76	GO:0010469	regulation of receptor activity
0.39	GO:0030728	ovulation
0.38	GO:0009755	hormone-mediated signaling pathway
0.37	GO:0007267	cell-cell signaling
0.37	GO:0007186	G-protein coupled receptor signaling pathway

0.79

GO:0005179

hormone activity

0.66	GO:0005576	extracellular region
0.33	GO:0005737	cytoplasm

sp|P01236|PRL_HUMAN
Prolactin
Search

PRL

0.91	Prolactin variant

0.76	GO:0010469	regulation of receptor activity
0.55	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II
0.54	GO:0001937	negative regulation of endothelial cell proliferation
0.54	GO:0046427	positive regulation of JAK-STAT cascade
0.53	GO:0040014	regulation of multicellular organism growth
0.50	GO:0007595	lactation
0.46	GO:0030072	peptide hormone secretion
0.45	GO:0045723	positive regulation of fatty acid biosynthetic process
0.42	GO:0043066	negative regulation of apoptotic process
0.40	GO:1903489	positive regulation of lactation

0.79	GO:0005179	hormone activity
0.49	GO:0005148	prolactin receptor binding
0.35	GO:0005125	cytokine activity

0.66	GO:0005576	extracellular region
0.36	GO:0031410	cytoplasmic vesicle
0.36	GO:0012505	endomembrane system
0.35	GO:0070013	intracellular organelle lumen
0.33	GO:0044446	intracellular organelle part
0.33	GO:0005829	cytosol
0.32	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016020	membrane

sp|P01241|SOMA_HUMAN
Somatotropin
Search

0.82	Chorionic somatomammotropin hormone B

0.76	GO:0010469	regulation of receptor activity
0.44	GO:0071375	cellular response to peptide hormone stimulus
0.41	GO:0032094	response to food
0.41	GO:0060416	response to growth hormone
0.41	GO:0040018	positive regulation of multicellular organism growth
0.41	GO:0007259	JAK-STAT cascade
0.40	GO:0032868	response to insulin
0.39	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway

0.79	GO:0005179	hormone activity
0.41	GO:0005131	growth hormone receptor binding
0.38	GO:0046872	metal ion binding

0.66	GO:0005576	extracellular region
0.44	GO:0031982	vesicle
0.42	GO:0012505	endomembrane system
0.38	GO:0043231	intracellular membrane-bounded organelle
0.38	GO:0044444	cytoplasmic part
0.37	GO:0044446	intracellular organelle part
0.37	GO:0043233	organelle lumen
0.35	GO:0005886	plasma membrane

sp|P01242|SOM2_HUMAN
Growth hormone variant
Search

0.83	Chorionic somatomammotropin hormone B

0.76	GO:0010469	regulation of receptor activity
0.44	GO:0071375	cellular response to peptide hormone stimulus
0.41	GO:0032094	response to food
0.41	GO:0060416	response to growth hormone
0.41	GO:0040018	positive regulation of multicellular organism growth
0.41	GO:0007259	JAK-STAT cascade
0.40	GO:0032868	response to insulin
0.39	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway

0.79	GO:0005179	hormone activity
0.41	GO:0005131	growth hormone receptor binding
0.38	GO:0046872	metal ion binding

0.66	GO:0005576	extracellular region
0.44	GO:0031982	vesicle
0.42	GO:0012505	endomembrane system
0.38	GO:0043231	intracellular membrane-bounded organelle
0.38	GO:0044444	cytoplasmic part
0.37	GO:0044446	intracellular organelle part
0.37	GO:0043233	organelle lumen
0.35	GO:0005886	plasma membrane

sp|P01258|CALC_HUMAN
Calcitonin
Search

0.97	Calcitonin receptor-stimulating peptide 1

0.76	GO:0010469	regulation of receptor activity
0.60	GO:0001984	artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure
0.57	GO:0045779	negative regulation of bone resorption
0.57	GO:0031645	negative regulation of neurological system process
0.57	GO:0050965	detection of temperature stimulus involved in sensory perception of pain
0.56	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
0.56	GO:0007190	activation of adenylate cyclase activity
0.56	GO:0045986	negative regulation of smooth muscle contraction
0.56	GO:1990090	cellular response to nerve growth factor stimulus
0.56	GO:0002548	monocyte chemotaxis

0.79	GO:0005179	hormone activity
0.59	GO:0031716	calcitonin receptor binding
0.49	GO:0042802	identical protein binding
0.38	GO:0032403	protein complex binding

0.66	GO:0005576	extracellular region
0.54	GO:0043195	terminal bouton
0.52	GO:0043025	neuronal cell body
0.39	GO:0005737	cytoplasm
0.37	GO:0005634	nucleus

sp|P01266|THYG_HUMAN
Thyroglobulin
Search

0.69	Thyroglobulin

0.86	GO:0015705	iodide transport
0.85	GO:0042403	thyroid hormone metabolic process
0.85	GO:0031641	regulation of myelination
0.85	GO:0030878	thyroid gland development
0.56	GO:0042446	hormone biosynthetic process
0.54	GO:0010469	regulation of receptor activity
0.53	GO:0045056	transcytosis
0.50	GO:0009268	response to pH
0.50	GO:0032496	response to lipopolysaccharide
0.33	GO:0097105	presynaptic membrane assembly

0.56	GO:0005179	hormone activity
0.48	GO:0051087	chaperone binding
0.47	GO:0042803	protein homodimerization activity
0.47	GO:0032403	protein complex binding
0.39	GO:0043168	anion binding
0.33	GO:0042043	neurexin family protein binding
0.32	GO:0052689	carboxylic ester hydrolase activity
0.32	GO:0004872	receptor activity

0.71	GO:0005615	extracellular space
0.49	GO:0048471	perinuclear region of cytoplasm
0.46	GO:0005794	Golgi apparatus
0.45	GO:0005783	endoplasmic reticulum
0.41	GO:0043234	protein complex
0.33	GO:0005634	nucleus
0.32	GO:0009986	cell surface
0.32	GO:0045202	synapse
0.32	GO:0005887	integral component of plasma membrane

0.32	EC:3.1.1 EC:3.1.1.1	GO:0052689
0.32	KEGG:R00630	GO:0052689

sp|P01270|PTHY_HUMAN
Parathyroid hormone
Search

PTH

0.97	Parathyroid hormone

0.81	GO:0046326	positive regulation of glucose import
0.80	GO:0006874	cellular calcium ion homeostasis
0.76	GO:0010469	regulation of receptor activity
0.70	GO:0090290	positive regulation of osteoclast proliferation
0.69	GO:0071865	regulation of apoptotic process in bone marrow
0.69	GO:0060732	positive regulation of inositol phosphate biosynthetic process
0.69	GO:0045725	positive regulation of glycogen biosynthetic process
0.69	GO:0071864	positive regulation of cell proliferation in bone marrow
0.68	GO:0007202	activation of phospholipase C activity
0.67	GO:0030819	positive regulation of cAMP biosynthetic process

0.79	GO:0005179	hormone activity
0.73	GO:0031856	parathyroid hormone receptor binding
0.68	GO:0051428	peptide hormone receptor binding
0.65	GO:0047485	protein N-terminus binding
0.65	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

0.66	GO:0005576	extracellular region
0.40	GO:0005622	intracellular
0.30	GO:0016020	membrane

sp|P01275|GLUC_HUMAN
Glucagon
Search

GCG

0.96	Preproglucagon B

0.76	GO:0010469	regulation of receptor activity
0.61	GO:0032099	negative regulation of appetite
0.59	GO:0010737	protein kinase A signaling
0.59	GO:0035948	positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
0.59	GO:1900118	negative regulation of execution phase of apoptosis
0.58	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
0.58	GO:0090280	positive regulation of calcium ion import
0.58	GO:0051571	positive regulation of histone H3-K4 methylation
0.58	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
0.56	GO:0033138	positive regulation of peptidyl-serine phosphorylation

0.79	GO:0005179	hormone activity
0.51	GO:0042802	identical protein binding
0.49	GO:0031769	glucagon receptor binding
0.37	GO:0017171	serine hydrolase activity
0.36	GO:0070011	peptidase activity, acting on L-amino acid peptides
0.34	GO:0004386	helicase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0003677	DNA binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding

0.66	GO:0005576	extracellular region
0.39	GO:0005737	cytoplasm
0.36	GO:0031983	vesicle lumen
0.35	GO:0097708	intracellular vesicle
0.34	GO:0012505	endomembrane system
0.34	GO:0070013	intracellular organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane
0.30	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0071944	cell periphery

sp|P01282|VIP_HUMAN
VIP peptides
Search

VIP

0.97	Vasoactive intestinal polypeptide

0.77	GO:0070459	prolactin secretion
0.76	GO:0010469	regulation of receptor activity
0.73	GO:0048255	mRNA stabilization
0.60	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
0.60	GO:0019933	cAMP-mediated signaling
0.55	GO:0045732	positive regulation of protein catabolic process
0.54	GO:0032880	regulation of protein localization
0.43	GO:0007218	neuropeptide signaling pathway
0.41	GO:0007399	nervous system development
0.41	GO:0010562	positive regulation of phosphorus metabolic process

0.79	GO:0005179	hormone activity
0.40	GO:0051428	peptide hormone receptor binding
0.35	GO:0005057	signal transducer activity, downstream of receptor
0.35	GO:0031858	pituitary adenylate cyclase-activating polypeptide receptor binding

0.66	GO:0005576	extracellular region
0.38	GO:0005622	intracellular
0.37	GO:0097458	neuron part
0.37	GO:0044297	cell body
0.36	GO:0120025	plasma membrane bounded cell projection
0.33	GO:0044456	synapse part
0.33	GO:0044463	cell projection part
0.30	GO:0016020	membrane

sp|P01286|SLIB_HUMAN
Somatoliberin
Search

GHRH

0.89	somatoliberin precursor

0.76	GO:0010469	regulation of receptor activity
0.65	GO:0030252	growth hormone secretion
0.65	GO:0060124	positive regulation of growth hormone secretion
0.64	GO:0021984	adenohypophysis development
0.64	GO:0032094	response to food
0.62	GO:0040018	positive regulation of multicellular organism growth
0.61	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.58	GO:0008284	positive regulation of cell proliferation
0.50	GO:0046005	positive regulation of circadian sleep/wake cycle, REM sleep
0.47	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway

0.79	GO:0005179	hormone activity
0.68	GO:0031770	growth hormone-releasing hormone receptor binding

0.66	GO:0005576	extracellular region
0.62	GO:0043195	terminal bouton
0.39	GO:0005622	intracellular

sp|P01298|PAHO_HUMAN
Pancreatic prohormone
Search

PPY

0.97	Pancreatic prohormone precursor

0.76	GO:0010469	regulation of receptor activity
0.57	GO:0032098	regulation of appetite
0.56	GO:0007631	feeding behavior
0.56	GO:0007586	digestion
0.54	GO:0007218	neuropeptide signaling pathway
0.51	GO:0007267	cell-cell signaling
0.37	GO:0009306	protein secretion

0.79	GO:0005179	hormone activity
0.64	GO:0001664	G-protein coupled receptor binding

0.66	GO:0005576	extracellular region
0.41	GO:0005737	cytoplasm

sp|P01303|NPY_HUMAN
Pro-neuropeptide Y
Search

NPY

0.95	Prepro-neuropeptide Y

0.76	GO:0010469	regulation of receptor activity
0.74	GO:0007218	neuropeptide signaling pathway
0.56	GO:0021954	central nervous system neuron development
0.56	GO:0021987	cerebral cortex development
0.55	GO:0008217	regulation of blood pressure
0.53	GO:0031175	neuron projection development
0.49	GO:0032098	regulation of appetite
0.48	GO:0007631	feeding behavior
0.45	GO:0007267	cell-cell signaling
0.44	GO:0032097	positive regulation of response to food

0.79	GO:0005179	hormone activity
0.56	GO:0001664	G-protein coupled receptor binding
0.35	GO:0005246	calcium channel regulator activity
0.34	GO:0004930	G-protein coupled receptor activity

0.66	GO:0005576	extracellular region
0.50	GO:0005794	Golgi apparatus
0.35	GO:0043204	perikaryon
0.35	GO:0043195	terminal bouton
0.34	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|P01308|INS_HUMAN
Insulin
Search

INS

0.95

Insulin

0.76	GO:0010469	regulation of receptor activity
0.70	GO:0006006	glucose metabolic process
0.51	GO:0045818	negative regulation of glycogen catabolic process
0.51	GO:0050995	negative regulation of lipid catabolic process
0.51	GO:0010243	response to organonitrogen compound
0.51	GO:0033861	negative regulation of NAD(P)H oxidase activity
0.50	GO:1902952	positive regulation of dendritic spine maintenance
0.50	GO:0060266	negative regulation of respiratory burst involved in inflammatory response
0.50	GO:2000252	negative regulation of feeding behavior
0.50	GO:0046628	positive regulation of insulin receptor signaling pathway

0.79	GO:0005179	hormone activity
0.54	GO:0005159	insulin-like growth factor receptor binding
0.51	GO:0005158	insulin receptor binding
0.49	GO:0002020	protease binding
0.45	GO:0042802	identical protein binding
0.36	GO:0051087	chaperone binding

0.66	GO:0005576	extracellular region
0.41	GO:0030141	secretory granule
0.39	GO:0060205	cytoplasmic vesicle lumen
0.37	GO:0005829	cytosol
0.36	GO:0005732	small nucleolar ribonucleoprotein complex
0.36	GO:0031904	endosome lumen
0.36	GO:0005796	Golgi lumen
0.36	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
0.36	GO:0005788	endoplasmic reticulum lumen
0.35	GO:0030133	transport vesicle

sp|P01344|IGF2_HUMAN
Insulin-like growth factor II
Search

IGF2

0.94	Insulin like growth factor 2

0.75	GO:0010469	regulation of receptor activity
0.54	GO:0046628	positive regulation of insulin receptor signaling pathway
0.53	GO:0042104	positive regulation of activated T cell proliferation
0.52	GO:0051897	positive regulation of protein kinase B signaling
0.51	GO:0045840	positive regulation of mitotic nuclear division
0.49	GO:0043410	positive regulation of MAPK cascade
0.45	GO:0032868	response to insulin
0.45	GO:0048568	embryonic organ development
0.44	GO:0043009	chordate embryonic development
0.44	GO:0051781	positive regulation of cell division

0.79	GO:0005179	hormone activity
0.77	GO:0008083	growth factor activity
0.54	GO:0005159	insulin-like growth factor receptor binding
0.53	GO:0005158	insulin receptor binding
0.38	GO:0043539	protein serine/threonine kinase activator activity

0.72	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.36	GO:0031093	platelet alpha granule lumen
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P01350|GAST_HUMAN
Gastrin
Search

GAST

0.97

Gastrin

0.74	GO:0010469	regulation of receptor activity
0.62	GO:0032094	response to food
0.51	GO:0007186	G-protein coupled receptor signaling pathway

0.78

GO:0005179

hormone activity

0.66

GO:0005576

extracellular region

sp|P01374|TNFB_HUMAN
Lymphotoxin-alpha
Search

LTA

0.95	Tumor necrosis factor

0.74	GO:0006955	immune response
0.74	GO:0010469	regulation of receptor activity
0.73	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus
0.72	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin
0.70	GO:0048535	lymph node development
0.70	GO:0044130	negative regulation of growth of symbiont in host
0.68	GO:0032729	positive regulation of interferon-gamma production
0.67	GO:0050830	defense response to Gram-positive bacterium
0.46	GO:0060252	positive regulation of glial cell proliferation
0.45	GO:0048147	negative regulation of fibroblast proliferation

0.83	GO:0005164	tumor necrosis factor receptor binding
0.78	GO:0005125	cytokine activity

0.71	GO:0005615	extracellular space
0.35	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P01375|TNFA_HUMAN
Tumor necrosis factor
Search

TNF

0.93	Tumor necrosis factor alpha

0.75	GO:0010469	regulation of receptor activity
0.74	GO:0006955	immune response
0.71	GO:0097527	necroptotic signaling pathway
0.62	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.62	GO:0043507	positive regulation of JUN kinase activity
0.60	GO:0061048	negative regulation of branching involved in lung morphogenesis
0.60	GO:1904999	positive regulation of leukocyte adhesion to arterial endothelial cell
0.60	GO:0045994	positive regulation of translational initiation by iron
0.60	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus
0.60	GO:0043243	positive regulation of protein complex disassembly

0.83	GO:0005164	tumor necrosis factor receptor binding
0.80	GO:0005125	cytokine activity
0.55	GO:0002020	protease binding
0.51	GO:0044212	transcription regulatory region DNA binding
0.50	GO:0042802	identical protein binding

0.73	GO:0005615	extracellular space
0.57	GO:0001891	phagocytic cup
0.55	GO:0055037	recycling endosome
0.54	GO:0009897	external side of plasma membrane
0.54	GO:0098857	membrane microdomain
0.47	GO:0005887	integral component of plasma membrane
0.34	GO:0030141	secretory granule

sp|P01562|IFNA1_HUMAN
Interferon alpha-1/13
Search

0.92	Interferon alpha

0.77	GO:0051607	defense response to virus
0.75	GO:0010469	regulation of receptor activity
0.57	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
0.57	GO:0002323	natural killer cell activation involved in immune response
0.56	GO:0042100	B cell proliferation
0.56	GO:0002286	T cell activation involved in immune response
0.56	GO:0043330	response to exogenous dsRNA
0.55	GO:0030183	B cell differentiation
0.54	GO:0002250	adaptive immune response
0.54	GO:0006959	humoral immune response

0.80	GO:0005125	cytokine activity
0.79	GO:0005126	cytokine receptor binding
0.50	GO:0032403	protein complex binding

0.73	GO:0005615	extracellular space
0.31	GO:0005622	intracellular

sp|P01563|IFNA2_HUMAN
Interferon alpha-2
Search

0.89	Interferon alpha-N

0.77	GO:0051607	defense response to virus
0.75	GO:0010469	regulation of receptor activity
0.54	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
0.54	GO:0002323	natural killer cell activation involved in immune response
0.53	GO:0042100	B cell proliferation
0.53	GO:0002286	T cell activation involved in immune response
0.52	GO:0043330	response to exogenous dsRNA
0.52	GO:0030183	B cell differentiation
0.51	GO:0006959	humoral immune response
0.51	GO:0002250	adaptive immune response

0.80	GO:0005125	cytokine activity
0.79	GO:0005126	cytokine receptor binding
0.48	GO:0032403	protein complex binding

0.73

GO:0005615

extracellular space

sp|P01566|IFN10_HUMAN
Interferon alpha-10
Search

0.91	Interferon alpha-N

0.78	GO:0051607	defense response to virus
0.75	GO:0010469	regulation of receptor activity
0.56	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
0.56	GO:0002323	natural killer cell activation involved in immune response
0.55	GO:0042100	B cell proliferation
0.54	GO:0002286	T cell activation involved in immune response
0.54	GO:0043330	response to exogenous dsRNA
0.54	GO:0030183	B cell differentiation
0.52	GO:0002250	adaptive immune response
0.52	GO:0006959	humoral immune response

0.80	GO:0005125	cytokine activity
0.79	GO:0005126	cytokine receptor binding
0.49	GO:0032403	protein complex binding

0.73

GO:0005615

extracellular space

sp|P01567|IFNA7_HUMAN
Interferon alpha-7
Search

0.92	Interferon alpha-N

0.78	GO:0051607	defense response to virus
0.75	GO:0010469	regulation of receptor activity
0.57	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
0.57	GO:0002323	natural killer cell activation involved in immune response
0.56	GO:0042100	B cell proliferation
0.55	GO:0002286	T cell activation involved in immune response
0.55	GO:0043330	response to exogenous dsRNA
0.55	GO:0030183	B cell differentiation
0.53	GO:0002250	adaptive immune response
0.53	GO:0006959	humoral immune response

0.80	GO:0005125	cytokine activity
0.79	GO:0005126	cytokine receptor binding
0.50	GO:0032403	protein complex binding

0.73	GO:0005615	extracellular space
0.31	GO:0005622	intracellular

sp|P01568|IFN21_HUMAN
Interferon alpha-21
Search

0.91	Interferon alpha-N

0.77	GO:0051607	defense response to virus
0.75	GO:0010469	regulation of receptor activity
0.56	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
0.56	GO:0002323	natural killer cell activation involved in immune response
0.55	GO:0042100	B cell proliferation
0.54	GO:0002286	T cell activation involved in immune response
0.54	GO:0043330	response to exogenous dsRNA
0.54	GO:0030183	B cell differentiation
0.52	GO:0002250	adaptive immune response
0.52	GO:0006959	humoral immune response

0.80	GO:0005125	cytokine activity
0.79	GO:0005126	cytokine receptor binding
0.49	GO:0032403	protein complex binding

0.73

GO:0005615

extracellular space

sp|P01569|IFNA5_HUMAN
Interferon alpha-5
Search

0.92	Interferon alpha-N

0.77	GO:0051607	defense response to virus
0.75	GO:0010469	regulation of receptor activity
0.56	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
0.56	GO:0002323	natural killer cell activation involved in immune response
0.55	GO:0042100	B cell proliferation
0.54	GO:0002286	T cell activation involved in immune response
0.54	GO:0043330	response to exogenous dsRNA
0.54	GO:0030183	B cell differentiation
0.52	GO:0002250	adaptive immune response
0.52	GO:0006959	humoral immune response

0.80	GO:0005125	cytokine activity
0.79	GO:0005126	cytokine receptor binding
0.49	GO:0032403	protein complex binding

0.73	GO:0005615	extracellular space
0.31	GO:0005622	intracellular

sp|P01570|IFN14_HUMAN
Interferon alpha-14
Search

0.91	Interferon alpha-N

0.77	GO:0051607	defense response to virus
0.75	GO:0010469	regulation of receptor activity
0.56	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
0.56	GO:0002323	natural killer cell activation involved in immune response
0.55	GO:0042100	B cell proliferation
0.55	GO:0002286	T cell activation involved in immune response
0.54	GO:0043330	response to exogenous dsRNA
0.54	GO:0030183	B cell differentiation
0.53	GO:0002250	adaptive immune response
0.53	GO:0006959	humoral immune response

0.80	GO:0005125	cytokine activity
0.79	GO:0005126	cytokine receptor binding
0.50	GO:0032403	protein complex binding

0.73

GO:0005615

extracellular space

sp|P01571|IFN17_HUMAN
Interferon alpha-17
Search

0.92	Interferon alpha-N

0.78	GO:0051607	defense response to virus
0.75	GO:0010469	regulation of receptor activity
0.56	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
0.56	GO:0002323	natural killer cell activation involved in immune response
0.55	GO:0042100	B cell proliferation
0.54	GO:0002286	T cell activation involved in immune response
0.54	GO:0043330	response to exogenous dsRNA
0.54	GO:0030183	B cell differentiation
0.52	GO:0002250	adaptive immune response
0.52	GO:0006959	humoral immune response

0.80	GO:0005125	cytokine activity
0.79	GO:0005126	cytokine receptor binding
0.49	GO:0032403	protein complex binding

0.73

GO:0005615

extracellular space

sp|P01574|IFNB_HUMAN
Interferon beta
Search

IFNB1

0.97	Interferon-alphaomega

0.77	GO:0051607	defense response to virus
0.75	GO:0010469	regulation of receptor activity
0.68	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
0.65	GO:0043330	response to exogenous dsRNA
0.65	GO:0002285	lymphocyte activation involved in immune response
0.64	GO:0042113	B cell activation
0.64	GO:2000552	negative regulation of T-helper 2 cell cytokine production
0.62	GO:0060337	type I interferon signaling pathway
0.62	GO:0035458	cellular response to interferon-beta
0.61	GO:0045581	negative regulation of T cell differentiation

0.80	GO:0005125	cytokine activity
0.79	GO:0005126	cytokine receptor binding
0.59	GO:0008811	chloramphenicol O-acetyltransferase activity
0.52	GO:0032403	protein complex binding

0.72

GO:0005615

extracellular space

0.59	EC:2.3.1.28	GO:0008811
0.59	KEGG:R03065	GO:0008811

sp|P01579|IFNG_HUMAN
Interferon gamma
Search

IFNG

0.94	Interferon gamma

0.74	GO:0006955	immune response
0.71	GO:0040008	regulation of growth
0.71	GO:0051607	defense response to virus
0.69	GO:0010469	regulation of receptor activity
0.64	GO:0060552	positive regulation of fructose 1,6-bisphosphate metabolic process
0.64	GO:0060549	regulation of fructose 1,6-bisphosphate 1-phosphatase activity
0.64	GO:0032834	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
0.63	GO:2000309	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
0.63	GO:0060557	positive regulation of vitamin D biosynthetic process
0.62	GO:0032747	positive regulation of interleukin-23 production

0.86	GO:0005133	interferon-gamma receptor binding
0.73	GO:0005125	cytokine activity

0.68	GO:0005615	extracellular space
0.38	GO:0005622	intracellular
0.30	GO:0016020	membrane

sp|P01583|IL1A_HUMAN
Interleukin-1 alpha
Search

IL1A

0.82	Interleukin-1 alpha

0.86	GO:0001660	fever generation
0.83	GO:0051781	positive regulation of cell division
0.75	GO:0010469	regulation of receptor activity
0.74	GO:0006955	immune response
0.66	GO:0045086	positive regulation of interleukin-2 biosynthetic process
0.66	GO:0002248	connective tissue replacement involved in inflammatory response wound healing
0.66	GO:0046688	response to copper ion
0.65	GO:2000391	positive regulation of neutrophil extravasation
0.65	GO:0034605	cellular response to heat
0.64	GO:0071639	positive regulation of monocyte chemotactic protein-1 production

0.86	GO:0005149	interleukin-1 receptor binding
0.80	GO:0005125	cytokine activity
0.59	GO:0005507	copper ion binding

0.73	GO:0005615	extracellular space
0.68	GO:0005829	cytosol
0.35	GO:0009986	cell surface
0.33	GO:0005886	plasma membrane

sp|P01584|IL1B_HUMAN
Interleukin-1 beta
Search

IL1B

0.46	Interleukin-1 beta

0.86	GO:0001660	fever generation
0.84	GO:0051781	positive regulation of cell division
0.76	GO:0010469	regulation of receptor activity
0.74	GO:0006955	immune response
0.61	GO:0035504	regulation of myosin light chain kinase activity
0.60	GO:0070487	monocyte aggregation
0.59	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity
0.59	GO:0030730	sequestering of triglyceride
0.59	GO:0071639	positive regulation of monocyte chemotactic protein-1 production
0.58	GO:0045086	positive regulation of interleukin-2 biosynthetic process

0.86	GO:0005149	interleukin-1 receptor binding
0.81	GO:0005125	cytokine activity
0.52	GO:0019904	protein domain specific binding

0.83	GO:0005776	autophagosome
0.80	GO:0070062	extracellular exosome
0.78	GO:0005764	lysosome
0.72	GO:0031410	cytoplasmic vesicle
0.68	GO:0005829	cytosol
0.41	GO:0012505	endomembrane system
0.30	GO:0016020	membrane

sp|P01588|EPO_HUMAN
Erythropoietin
Search

EPO

0.97	Erythropoietin

0.83	GO:0043249	erythrocyte maturation
0.76	GO:0010469	regulation of receptor activity
0.75	GO:0038162	erythropoietin-mediated signaling pathway
0.72	GO:1902250	regulation of erythrocyte apoptotic process
0.70	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
0.70	GO:0033033	negative regulation of myeloid cell apoptotic process
0.68	GO:0042541	hemoglobin biosynthetic process
0.67	GO:0010523	negative regulation of calcium ion transport into cytosol
0.67	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
0.66	GO:2001258	negative regulation of cation channel activity

0.87	GO:0005128	erythropoietin receptor binding
0.79	GO:0005179	hormone activity
0.63	GO:0030295	protein kinase activator activity
0.62	GO:0005125	cytokine activity

0.66	GO:0005576	extracellular region
0.59	GO:0009986	cell surface
0.44	GO:0044297	cell body
0.30	GO:0016020	membrane

sp|P01589|IL2RA_HUMAN
Interleukin-2 receptor subunit alpha
Search

IL2RA

0.97	Interleukin-2 receptor subunit alpha

0.87	GO:0038110	interleukin-2-mediated signaling pathway
0.70	GO:0002664	regulation of T cell tolerance induction
0.67	GO:0046013	regulation of T cell homeostatic proliferation
0.67	GO:0006924	activation-induced cell death of T cells
0.65	GO:0042104	positive regulation of activated T cell proliferation
0.63	GO:0042130	negative regulation of T cell proliferation
0.62	GO:0050728	negative regulation of inflammatory response
0.60	GO:0007219	Notch signaling pathway
0.52	GO:0006954	inflammatory response
0.49	GO:0006955	immune response

0.87	GO:0004911	interleukin-2 receptor activity
0.87	GO:0019976	interleukin-2 binding
0.38	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.37	GO:0008144	drug binding
0.34	GO:0003735	structural constituent of ribosome

0.60	GO:0009897	external side of plasma membrane
0.34	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

sp|P01591|IGJ_HUMAN
Immunoglobulin J chain
Search

JCHAIN

0.97	Joining chain of multimeric IgA and IgM

0.86	GO:0060267	positive regulation of respiratory burst
0.86	GO:0003094	glomerular filtration
0.86	GO:0032461	positive regulation of protein oligomerization
0.85	GO:0019731	antibacterial humoral response
0.82	GO:0002250	adaptive immune response
0.78	GO:0045087	innate immune response

0.87	GO:0019862	IgA binding
0.86	GO:0034987	immunoglobulin receptor binding
0.86	GO:0031210	phosphatidylcholine binding
0.79	GO:0030674	protein binding, bridging
0.76	GO:0042834	peptidoglycan binding
0.74	GO:0042803	protein homodimerization activity
0.73	GO:0003697	single-stranded DNA binding

0.88	GO:0071754	IgM immunoglobulin complex, circulating
0.87	GO:0071750	dimeric IgA immunoglobulin complex
0.87	GO:0071751	secretory IgA immunoglobulin complex
0.87	GO:0071748	monomeric IgA immunoglobulin complex
0.30	GO:0016020	membrane

sp|P01593|KVD33_HUMAN
Immunoglobulin kappa variable 1D-33
Search

0.97	Immunoglobulin kappa variable 1-5

0.77	GO:0002250	adaptive immune response
0.73	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.72	GO:0038095	Fc-epsilon receptor signaling pathway
0.71	GO:0002377	immunoglobulin production
0.70	GO:0030449	regulation of complement activation
0.68	GO:0002449	lymphocyte mediated immunity
0.67	GO:0006956	complement activation
0.67	GO:0050900	leukocyte migration
0.59	GO:0006898	receptor-mediated endocytosis
0.51	GO:0006508	proteolysis

0.80	GO:0003823	antigen binding
0.57	GO:0004252	serine-type endopeptidase activity
0.41	GO:0042802	identical protein binding

0.69	GO:0005615	extracellular space
0.62	GO:1903561	extracellular vesicle
0.53	GO:0005886	plasma membrane

0.57

GO:0004252

sp|P01594|KV133_HUMAN
Immunoglobulin kappa variable 1-33
Search

0.97	Immunoglobulin kappa variable 1-5

0.77	GO:0002250	adaptive immune response
0.73	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.72	GO:0038095	Fc-epsilon receptor signaling pathway
0.71	GO:0002377	immunoglobulin production
0.70	GO:0030449	regulation of complement activation
0.68	GO:0002449	lymphocyte mediated immunity
0.67	GO:0006956	complement activation
0.67	GO:0050900	leukocyte migration
0.59	GO:0006898	receptor-mediated endocytosis
0.51	GO:0006508	proteolysis

0.80	GO:0003823	antigen binding
0.57	GO:0004252	serine-type endopeptidase activity
0.41	GO:0042802	identical protein binding

0.69	GO:0005615	extracellular space
0.62	GO:1903561	extracellular vesicle
0.53	GO:0005886	plasma membrane

0.57

GO:0004252

sp|P01597|KV139_HUMAN
Immunoglobulin kappa variable 1-39
Search

0.97	Immunoglobulin kappa variable 1-9

0.78	GO:0002250	adaptive immune response
0.73	GO:0002377	immunoglobulin production
0.71	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.70	GO:0038095	Fc-epsilon receptor signaling pathway
0.68	GO:0030449	regulation of complement activation
0.66	GO:0002449	lymphocyte mediated immunity
0.66	GO:0006956	complement activation
0.65	GO:0050900	leukocyte migration
0.58	GO:0006898	receptor-mediated endocytosis
0.50	GO:0006508	proteolysis

0.81	GO:0003823	antigen binding
0.56	GO:0004252	serine-type endopeptidase activity
0.39	GO:0042802	identical protein binding

0.70	GO:0005615	extracellular space
0.60	GO:1903561	extracellular vesicle
0.53	GO:0005886	plasma membrane

0.56

GO:0004252

sp|P01599|KV117_HUMAN
Immunoglobulin kappa variable 1-17
Search

0.97	Immunoglobulin kappa variable 1-6

0.78	GO:0002250	adaptive immune response
0.73	GO:0002377	immunoglobulin production
0.71	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.70	GO:0038095	Fc-epsilon receptor signaling pathway
0.68	GO:0030449	regulation of complement activation
0.66	GO:0002449	lymphocyte mediated immunity
0.66	GO:0006956	complement activation
0.65	GO:0050900	leukocyte migration
0.58	GO:0006898	receptor-mediated endocytosis
0.50	GO:0006508	proteolysis

0.81	GO:0003823	antigen binding
0.56	GO:0004252	serine-type endopeptidase activity
0.39	GO:0042802	identical protein binding

0.70	GO:0005615	extracellular space
0.60	GO:1903561	extracellular vesicle
0.53	GO:0005886	plasma membrane

0.56

GO:0004252

sp|P01601|KVD16_HUMAN
Immunoglobulin kappa variable 1D-16 (Fragment)
Search

0.97	Immunoglobulin kappa variable 1-5

0.78	GO:0002250	adaptive immune response
0.73	GO:0002377	immunoglobulin production
0.71	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.70	GO:0038095	Fc-epsilon receptor signaling pathway
0.68	GO:0030449	regulation of complement activation
0.66	GO:0002449	lymphocyte mediated immunity
0.66	GO:0006956	complement activation
0.65	GO:0050900	leukocyte migration
0.58	GO:0006898	receptor-mediated endocytosis
0.50	GO:0006508	proteolysis

0.81	GO:0003823	antigen binding
0.56	GO:0004252	serine-type endopeptidase activity
0.39	GO:0042802	identical protein binding

0.70	GO:0005615	extracellular space
0.60	GO:1903561	extracellular vesicle
0.53	GO:0005886	plasma membrane

0.56

GO:0004252

sp|P01602|KV105_HUMAN
Immunoglobulin kappa variable 1-5
Search

0.97	Immunoglobulin kappa variable 1-5

0.78	GO:0002250	adaptive immune response
0.73	GO:0002377	immunoglobulin production
0.70	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.69	GO:0038095	Fc-epsilon receptor signaling pathway
0.67	GO:0030449	regulation of complement activation
0.65	GO:0002449	lymphocyte mediated immunity
0.65	GO:0006956	complement activation
0.65	GO:0050900	leukocyte migration
0.57	GO:0006898	receptor-mediated endocytosis
0.50	GO:0006508	proteolysis

0.81	GO:0003823	antigen binding
0.55	GO:0004252	serine-type endopeptidase activity
0.39	GO:0042802	identical protein binding

0.70	GO:0005615	extracellular space
0.60	GO:1903561	extracellular vesicle
0.53	GO:0005886	plasma membrane

0.55

GO:0004252

sp|P01611|KVD12_HUMAN
Immunoglobulin kappa variable 1D-12
Search

0.97	Immunoglobulin kappa variable 1-9

0.78	GO:0002250	adaptive immune response
0.73	GO:0002377	immunoglobulin production
0.71	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.70	GO:0038095	Fc-epsilon receptor signaling pathway
0.68	GO:0030449	regulation of complement activation
0.66	GO:0002449	lymphocyte mediated immunity
0.66	GO:0006956	complement activation
0.65	GO:0050900	leukocyte migration
0.58	GO:0006898	receptor-mediated endocytosis
0.50	GO:0006508	proteolysis

0.81	GO:0003823	antigen binding
0.56	GO:0004252	serine-type endopeptidase activity
0.39	GO:0042802	identical protein binding

0.70	GO:0005615	extracellular space
0.60	GO:1903561	extracellular vesicle
0.53	GO:0005886	plasma membrane

0.56

GO:0004252

sp|P01614|KVD40_HUMAN
Immunoglobulin kappa variable 2D-40
Search

0.83	Immunoglobulin kappa variable 2-40

0.73	GO:0002250	adaptive immune response
0.70	GO:0002377	immunoglobulin production
0.69	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.68	GO:0038095	Fc-epsilon receptor signaling pathway
0.66	GO:0030449	regulation of complement activation
0.64	GO:0002449	lymphocyte mediated immunity
0.64	GO:0006956	complement activation
0.63	GO:0050900	leukocyte migration
0.56	GO:0006898	receptor-mediated endocytosis
0.49	GO:0006508	proteolysis

0.78	GO:0003823	antigen binding
0.54	GO:0004252	serine-type endopeptidase activity
0.36	GO:0046872	metal ion binding

0.67	GO:0005615	extracellular space
0.53	GO:1903561	extracellular vesicle
0.51	GO:0005886	plasma membrane

0.54

GO:0004252

sp|P01615|KVD28_HUMAN
Immunoglobulin kappa variable 2D-28
Search

0.96	Immunoglobulin kappa variable 2-28

0.82	GO:0002377	immunoglobulin production
0.74	GO:0006955	immune response
0.55	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.54	GO:0038095	Fc-epsilon receptor signaling pathway
0.53	GO:0030449	regulation of complement activation
0.52	GO:0002449	lymphocyte mediated immunity
0.51	GO:0072376	protein activation cascade
0.51	GO:0050900	leukocyte migration
0.47	GO:0006898	receptor-mediated endocytosis
0.42	GO:0006508	proteolysis

0.59	GO:0003823	antigen binding
0.46	GO:0004252	serine-type endopeptidase activity

0.72	GO:0005615	extracellular space
0.45	GO:1903561	extracellular vesicle
0.43	GO:0005886	plasma membrane

0.46

GO:0004252

sp|P01619|KV320_HUMAN
Immunoglobulin kappa variable 3-20
Search

0.91	Ig kappa chain V-III region VG

0.81	GO:0002377	immunoglobulin production
0.73	GO:0006955	immune response
0.54	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.54	GO:0038095	Fc-epsilon receptor signaling pathway
0.52	GO:0030449	regulation of complement activation
0.51	GO:0002449	lymphocyte mediated immunity
0.51	GO:0072376	protein activation cascade
0.51	GO:0050900	leukocyte migration
0.47	GO:0003094	glomerular filtration
0.46	GO:0006898	receptor-mediated endocytosis

0.60	GO:0003823	antigen binding
0.45	GO:0004252	serine-type endopeptidase activity
0.37	GO:0051082	unfolded protein binding
0.35	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.73	GO:0005615	extracellular space
0.49	GO:0071745	IgA immunoglobulin complex
0.48	GO:0071753	IgM immunoglobulin complex
0.47	GO:1903561	extracellular vesicle
0.44	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.45

GO:0004252

sp|P01624|KV315_HUMAN
Immunoglobulin kappa variable 3-15
Search

0.90	Ig kappa chain V-III region VG

0.78	GO:0002377	immunoglobulin production
0.73	GO:0006955	immune response
0.58	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.57	GO:0038095	Fc-epsilon receptor signaling pathway
0.56	GO:0030449	regulation of complement activation
0.54	GO:0002449	lymphocyte mediated immunity
0.54	GO:0072376	protein activation cascade
0.54	GO:0050900	leukocyte migration
0.49	GO:0006898	receptor-mediated endocytosis
0.46	GO:0003094	glomerular filtration

0.66	GO:0003823	antigen binding
0.47	GO:0004252	serine-type endopeptidase activity
0.37	GO:0051082	unfolded protein binding
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.71	GO:0005615	extracellular space
0.51	GO:1903561	extracellular vesicle
0.47	GO:0071745	IgA immunoglobulin complex
0.47	GO:0071753	IgM immunoglobulin complex
0.46	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.47

GO:0004252

sp|P01699|LV144_HUMAN
Immunoglobulin lambda variable 1-44
Search

0.83	Anti-streptococcal/anti-myosin immunoglobulin lambda light chain variable region (Fragment)

0.82	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.80	GO:0038095	Fc-epsilon receptor signaling pathway
0.79	GO:0002250	adaptive immune response
0.78	GO:0030449	regulation of complement activation
0.75	GO:0002449	lymphocyte mediated immunity
0.75	GO:0006956	complement activation
0.74	GO:0050900	leukocyte migration
0.65	GO:0006898	receptor-mediated endocytosis
0.62	GO:0002377	immunoglobulin production
0.55	GO:0006508	proteolysis

0.82	GO:0003823	antigen binding
0.62	GO:0004252	serine-type endopeptidase activity

0.66	GO:0005576	extracellular region
0.55	GO:0031982	vesicle
0.54	GO:0005886	plasma membrane

0.62

GO:0004252

sp|P01700|LV147_HUMAN
Immunoglobulin lambda variable 1-47
Search

0.84	Anti-streptococcal/anti-myosin immunoglobulin lambda light chain variable region (Fragment)

0.82	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.80	GO:0038095	Fc-epsilon receptor signaling pathway
0.79	GO:0002250	adaptive immune response
0.78	GO:0030449	regulation of complement activation
0.75	GO:0002449	lymphocyte mediated immunity
0.75	GO:0006956	complement activation
0.74	GO:0050900	leukocyte migration
0.65	GO:0006898	receptor-mediated endocytosis
0.61	GO:0002377	immunoglobulin production
0.55	GO:0006508	proteolysis

0.82	GO:0003823	antigen binding
0.62	GO:0004252	serine-type endopeptidase activity

0.66	GO:0005576	extracellular region
0.55	GO:0031982	vesicle
0.54	GO:0005886	plasma membrane

0.62

GO:0004252

sp|P01701|LV151_HUMAN
Immunoglobulin lambda variable 1-51
Search

0.86	Anti-streptococcal/anti-myosin immunoglobulin lambda light chain variable region (Fragment)

0.82	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.80	GO:0038095	Fc-epsilon receptor signaling pathway
0.79	GO:0002250	adaptive immune response
0.78	GO:0030449	regulation of complement activation
0.75	GO:0002449	lymphocyte mediated immunity
0.75	GO:0006956	complement activation
0.74	GO:0050900	leukocyte migration
0.65	GO:0006898	receptor-mediated endocytosis
0.61	GO:0002377	immunoglobulin production
0.56	GO:0006508	proteolysis

0.82	GO:0003823	antigen binding
0.62	GO:0004252	serine-type endopeptidase activity

0.66	GO:0005576	extracellular region
0.56	GO:0031982	vesicle
0.54	GO:0005886	plasma membrane

0.62

GO:0004252

sp|P01703|LV140_HUMAN
Immunoglobulin lambda variable 1-40
Search

0.90	Immunoglobulin lambda variable 1-40

0.79	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.79	GO:0002250	adaptive immune response
0.78	GO:0038095	Fc-epsilon receptor signaling pathway
0.76	GO:0030449	regulation of complement activation
0.73	GO:0002449	lymphocyte mediated immunity
0.73	GO:0006956	complement activation
0.72	GO:0050900	leukocyte migration
0.64	GO:0002377	immunoglobulin production
0.63	GO:0006898	receptor-mediated endocytosis
0.54	GO:0006508	proteolysis

0.82	GO:0003823	antigen binding
0.61	GO:0004252	serine-type endopeptidase activity

0.67	GO:0005615	extracellular space
0.61	GO:1903561	extracellular vesicle
0.54	GO:0005886	plasma membrane

0.61

GO:0004252

sp|P01704|LV214_HUMAN
Immunoglobulin lambda variable 2-14
Search

0.86	Ig lambda chain V-II region MGC

0.76	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.75	GO:0038095	Fc-epsilon receptor signaling pathway
0.74	GO:0006955	immune response
0.73	GO:0030449	regulation of complement activation
0.70	GO:0002449	lymphocyte mediated immunity
0.70	GO:0072376	protein activation cascade
0.70	GO:0050900	leukocyte migration
0.68	GO:0002377	immunoglobulin production
0.61	GO:0006898	receptor-mediated endocytosis
0.53	GO:0006508	proteolysis

0.77	GO:0003823	antigen binding
0.59	GO:0004252	serine-type endopeptidase activity

0.67	GO:0005615	extracellular space
0.57	GO:1903561	extracellular vesicle
0.51	GO:0005886	plasma membrane

0.59

GO:0004252

sp|P01705|LV223_HUMAN
Immunoglobulin lambda variable 2-23
Search

0.87	Ig lambda chain V-II region BUR

0.77	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.76	GO:0038095	Fc-epsilon receptor signaling pathway
0.74	GO:0002250	adaptive immune response
0.73	GO:0030449	regulation of complement activation
0.71	GO:0002449	lymphocyte mediated immunity
0.71	GO:0006956	complement activation
0.70	GO:0050900	leukocyte migration
0.67	GO:0002377	immunoglobulin production
0.62	GO:0006898	receptor-mediated endocytosis
0.53	GO:0006508	proteolysis

0.77	GO:0003823	antigen binding
0.59	GO:0004252	serine-type endopeptidase activity

0.67	GO:0005615	extracellular space
0.57	GO:1903561	extracellular vesicle
0.51	GO:0005886	plasma membrane

0.59

GO:0004252

sp|P01706|LV211_HUMAN
Immunoglobulin lambda variable 2-11
Search

0.84	Ig lambda chain V-II region MGC

0.76	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.75	GO:0038095	Fc-epsilon receptor signaling pathway
0.74	GO:0006955	immune response
0.73	GO:0030449	regulation of complement activation
0.71	GO:0002449	lymphocyte mediated immunity
0.70	GO:0072376	protein activation cascade
0.70	GO:0050900	leukocyte migration
0.67	GO:0002377	immunoglobulin production
0.61	GO:0006898	receptor-mediated endocytosis
0.53	GO:0006508	proteolysis

0.77	GO:0003823	antigen binding
0.59	GO:0004252	serine-type endopeptidase activity

0.67	GO:0005615	extracellular space
0.58	GO:1903561	extracellular vesicle
0.51	GO:0005886	plasma membrane

0.59

GO:0004252

sp|P01709|LV208_HUMAN
Immunoglobulin lambda variable 2-8
Search

0.87	Ig lambda chain V-II region MGC

0.80	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.79	GO:0038095	Fc-epsilon receptor signaling pathway
0.77	GO:0002250	adaptive immune response
0.77	GO:0030449	regulation of complement activation
0.74	GO:0002449	lymphocyte mediated immunity
0.74	GO:0006956	complement activation
0.73	GO:0050900	leukocyte migration
0.64	GO:0006898	receptor-mediated endocytosis
0.63	GO:0002377	immunoglobulin production
0.55	GO:0006508	proteolysis

0.80	GO:0003823	antigen binding
0.62	GO:0004252	serine-type endopeptidase activity

0.66	GO:0005576	extracellular region
0.53	GO:0005886	plasma membrane
0.52	GO:0031982	vesicle

0.62

GO:0004252

sp|P01714|LV319_HUMAN
Immunoglobulin lambda variable 3-19
Search

0.79	Ig lambda chain V-III region LOI

0.76	GO:0002250	adaptive immune response
0.74	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.72	GO:0038095	Fc-epsilon receptor signaling pathway
0.70	GO:0030449	regulation of complement activation
0.70	GO:0002377	immunoglobulin production
0.68	GO:0002449	lymphocyte mediated immunity
0.68	GO:0006956	complement activation
0.67	GO:0050900	leukocyte migration
0.59	GO:0006898	receptor-mediated endocytosis
0.52	GO:0006508	proteolysis

0.79	GO:0003823	antigen binding
0.57	GO:0004252	serine-type endopeptidase activity

0.70	GO:0005615	extracellular space
0.60	GO:1903561	extracellular vesicle
0.52	GO:0005886	plasma membrane

0.57

GO:0004252

sp|P01715|LV301_HUMAN
Immunoglobulin lambda variable 3-1
Search

0.87	Ig lambda chain V-III region LOI

0.83	GO:0002250	adaptive immune response
0.73	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.72	GO:0038095	Fc-epsilon receptor signaling pathway
0.71	GO:0002377	immunoglobulin production
0.70	GO:0030449	regulation of complement activation
0.68	GO:0002449	lymphocyte mediated immunity
0.67	GO:0006956	complement activation
0.67	GO:0050900	leukocyte migration
0.59	GO:0006898	receptor-mediated endocytosis
0.51	GO:0006508	proteolysis

0.85	GO:0003823	antigen binding
0.57	GO:0004252	serine-type endopeptidase activity

0.68	GO:0005615	extracellular space
0.56	GO:0005886	plasma membrane
0.54	GO:1903561	extracellular vesicle

0.57

GO:0004252

sp|P01717|LV325_HUMAN
Immunoglobulin lambda variable 3-25
Search

0.83	Ig lambda chain V-III region LOI

0.81	GO:0002250	adaptive immune response
0.73	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.72	GO:0038095	Fc-epsilon receptor signaling pathway
0.71	GO:0002377	immunoglobulin production
0.70	GO:0030449	regulation of complement activation
0.67	GO:0002449	lymphocyte mediated immunity
0.67	GO:0006956	complement activation
0.67	GO:0050900	leukocyte migration
0.59	GO:0006898	receptor-mediated endocytosis
0.51	GO:0006508	proteolysis

0.84	GO:0003823	antigen binding
0.57	GO:0004252	serine-type endopeptidase activity

0.69	GO:0005615	extracellular space
0.57	GO:1903561	extracellular vesicle
0.55	GO:0005886	plasma membrane

0.57

GO:0004252

sp|P01718|LV327_HUMAN
Immunoglobulin lambda variable 3-27
Search

0.85	Ig lambda chain V-III region LOI

0.81	GO:0002250	adaptive immune response
0.73	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.72	GO:0038095	Fc-epsilon receptor signaling pathway
0.71	GO:0002377	immunoglobulin production
0.70	GO:0030449	regulation of complement activation
0.68	GO:0002449	lymphocyte mediated immunity
0.67	GO:0006956	complement activation
0.67	GO:0050900	leukocyte migration
0.59	GO:0006898	receptor-mediated endocytosis
0.51	GO:0006508	proteolysis

0.84	GO:0003823	antigen binding
0.57	GO:0004252	serine-type endopeptidase activity

0.68	GO:0005615	extracellular space
0.57	GO:1903561	extracellular vesicle
0.55	GO:0005886	plasma membrane

0.57

GO:0004252

sp|P01721|LV657_HUMAN
Immunoglobulin lambda variable 6-57
Search

0.95	Ig lambda chain V-VI region SUT

0.79	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.77	GO:0038095	Fc-epsilon receptor signaling pathway
0.76	GO:0002250	adaptive immune response
0.75	GO:0030449	regulation of complement activation
0.72	GO:0002449	lymphocyte mediated immunity
0.72	GO:0006956	complement activation
0.72	GO:0050900	leukocyte migration
0.65	GO:0002377	immunoglobulin production
0.63	GO:0006898	receptor-mediated endocytosis
0.54	GO:0006508	proteolysis

0.79	GO:0003823	antigen binding
0.61	GO:0004252	serine-type endopeptidase activity

0.67	GO:0005615	extracellular space
0.65	GO:1903561	extracellular vesicle
0.52	GO:0005886	plasma membrane

0.61

GO:0004252

sp|P01730|CD4_HUMAN
T-cell surface glycoprotein CD4
Search

CD4

0.91	T-cell surface glycoprotein CD4 variant

0.73	GO:0006955	immune response
0.71	GO:0007155	cell adhesion
0.60	GO:0007165	signal transduction
0.58	GO:0045058	T cell selection
0.56	GO:0006948	induction by virus of host cell-cell fusion
0.55	GO:0071350	cellular response to interleukin-15
0.55	GO:0046598	positive regulation of viral entry into host cell
0.55	GO:0045657	positive regulation of monocyte differentiation
0.54	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus
0.52	GO:0035397	helper T cell enhancement of adaptive immune response

0.85	GO:0015026	coreceptor activity
0.57	GO:0042012	interleukin-16 receptor activity
0.57	GO:0042011	interleukin-16 binding
0.54	GO:0042289	MHC class II protein binding
0.52	GO:1990782	protein tyrosine kinase binding
0.48	GO:0042803	protein homodimerization activity
0.43	GO:0008270	zinc ion binding
0.37	GO:0019865	immunoglobulin binding
0.36	GO:0001618	virus receptor activity
0.35	GO:0005201	extracellular matrix structural constituent

0.51	GO:0009897	external side of plasma membrane
0.50	GO:0098857	membrane microdomain
0.47	GO:0005788	endoplasmic reticulum lumen
0.45	GO:0005887	integral component of plasma membrane
0.44	GO:0005789	endoplasmic reticulum membrane
0.36	GO:0042101	T cell receptor complex
0.35	GO:0030665	clathrin-coated vesicle membrane
0.35	GO:0005769	early endosome

sp|P01732|CD8A_HUMAN
T-cell surface glycoprotein CD8 alpha chain
Search

CD8A

0.83	T-cell surface glycoprotein CD8 alpha chain

0.58	GO:0045065	cytotoxic T cell differentiation
0.54	GO:0002456	T cell mediated immunity
0.47	GO:0007166	cell surface receptor signaling pathway
0.40	GO:0050850	positive regulation of calcium-mediated signaling
0.38	GO:0051607	defense response to virus
0.37	GO:0019882	antigen processing and presentation
0.37	GO:0050776	regulation of immune response
0.36	GO:0006954	inflammatory response

0.40	GO:0042288	MHC class I protein binding
0.39	GO:0019901	protein kinase binding
0.39	GO:0015026	coreceptor activity
0.38	GO:0042803	protein homodimerization activity

0.62	GO:0009897	external side of plasma membrane
0.60	GO:0044853	plasma membrane raft
0.42	GO:0044214	spanning component of plasma membrane
0.39	GO:0042101	T cell receptor complex
0.36	GO:0005576	extracellular region

sp|P01733|TVB1_HUMAN
T-cell receptor beta chain V region YT35
Search

0.97	T-cell receptor beta variable 2

0.57	GO:0031295	T cell costimulation
0.56	GO:0050852	T cell receptor signaling pathway
0.52	GO:0006955	immune response
0.44	GO:0001562	response to protozoan
0.40	GO:0002377	immunoglobulin production

0.59	GO:0003823	antigen binding
0.56	GO:0042287	MHC protein binding
0.53	GO:0042277	peptide binding

0.42	GO:0005886	plasma membrane
0.38	GO:0005615	extracellular space
0.30	GO:0031224	intrinsic component of membrane

sp|P01737|TVA3_HUMAN
T-cell receptor alpha chain V region PY14
Search

0.97	T-cell receptor alpha variable 8-4

0.67	GO:0031295	T cell costimulation
0.65	GO:0050852	T cell receptor signaling pathway
0.60	GO:0006955	immune response
0.54	GO:0002377	immunoglobulin production

0.67	GO:0042605	peptide antigen binding
0.66	GO:0042287	MHC protein binding

0.49	GO:0005615	extracellular space
0.46	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P01742|HV169_HUMAN
Immunoglobulin heavy variable 1-69
Search

0.49	Immunoglobulin heavy variable 1-2

0.80	GO:0006958	complement activation, classical pathway
0.78	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.77	GO:0006909	phagocytosis
0.74	GO:0099024	plasma membrane invagination
0.73	GO:0050871	positive regulation of B cell activation
0.69	GO:0008037	cell recognition
0.68	GO:0045087	innate immune response
0.68	GO:0042742	defense response to bacterium
0.55	GO:0038094	Fc-gamma receptor signaling pathway
0.55	GO:0038095	Fc-epsilon receptor signaling pathway

0.84	GO:0003823	antigen binding
0.76	GO:0034987	immunoglobulin receptor binding
0.46	GO:0004252	serine-type endopeptidase activity

0.75	GO:0042571	immunoglobulin complex, circulating
0.74	GO:0072562	blood microparticle
0.71	GO:0009897	external side of plasma membrane
0.38	GO:0005887	integral component of plasma membrane

0.46

GO:0004252

sp|P01743|HV146_HUMAN
Immunoglobulin heavy variable 1-46
Search

0.49	Immunoglobulin heavy variable 1-2

0.79	GO:0006958	complement activation, classical pathway
0.77	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.77	GO:0006909	phagocytosis
0.73	GO:0099024	plasma membrane invagination
0.72	GO:0050871	positive regulation of B cell activation
0.69	GO:0008037	cell recognition
0.68	GO:0045087	innate immune response
0.67	GO:0042742	defense response to bacterium
0.56	GO:0038094	Fc-gamma receptor signaling pathway
0.55	GO:0038095	Fc-epsilon receptor signaling pathway

0.84	GO:0003823	antigen binding
0.75	GO:0034987	immunoglobulin receptor binding
0.46	GO:0004252	serine-type endopeptidase activity

0.74	GO:0042571	immunoglobulin complex, circulating
0.73	GO:0072562	blood microparticle
0.70	GO:0009897	external side of plasma membrane
0.38	GO:0005887	integral component of plasma membrane

0.46

GO:0004252

sp|P01762|HV311_HUMAN
Immunoglobulin heavy variable 3-11
Search

0.87	Immunoglobulin heavy constant mu

0.83	GO:0006958	complement activation, classical pathway
0.81	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.80	GO:0006909	phagocytosis
0.73	GO:0099024	plasma membrane invagination
0.72	GO:0050871	positive regulation of B cell activation
0.69	GO:0008037	cell recognition
0.67	GO:0045087	innate immune response
0.67	GO:0042742	defense response to bacterium
0.64	GO:0038094	Fc-gamma receptor signaling pathway
0.63	GO:0038095	Fc-epsilon receptor signaling pathway

0.85	GO:0003823	antigen binding
0.75	GO:0034987	immunoglobulin receptor binding
0.52	GO:0004252	serine-type endopeptidase activity

0.77	GO:0072562	blood microparticle
0.74	GO:0042571	immunoglobulin complex, circulating
0.70	GO:0009897	external side of plasma membrane
0.52	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.52

GO:0004252

sp|P01763|HV348_HUMAN
Immunoglobulin heavy variable 3-48
Search

0.97	Immunoglobulin heavy variable 3-7

0.85	GO:0006958	complement activation, classical pathway
0.84	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.84	GO:0006909	phagocytosis
0.75	GO:0099024	plasma membrane invagination
0.74	GO:0050871	positive regulation of B cell activation
0.71	GO:0038094	Fc-gamma receptor signaling pathway
0.71	GO:0038095	Fc-epsilon receptor signaling pathway
0.70	GO:0008037	cell recognition
0.69	GO:0045087	innate immune response
0.69	GO:0030449	regulation of complement activation

0.85	GO:0003823	antigen binding
0.77	GO:0034987	immunoglobulin receptor binding
0.56	GO:0004252	serine-type endopeptidase activity

0.80	GO:0072562	blood microparticle
0.76	GO:0042571	immunoglobulin complex, circulating
0.71	GO:0009897	external side of plasma membrane
0.58	GO:0070062	extracellular exosome

0.56

GO:0004252

sp|P01764|HV323_HUMAN
Immunoglobulin heavy variable 3-23
Search

0.97	Immunoglobulin heavy variable 3-7

0.83	GO:0002250	adaptive immune response
0.80	GO:0002449	lymphocyte mediated immunity
0.80	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.80	GO:0006956	complement activation
0.79	GO:0006909	phagocytosis
0.74	GO:0099024	plasma membrane invagination
0.73	GO:0050871	positive regulation of B cell activation
0.69	GO:0008037	cell recognition
0.68	GO:0045087	innate immune response
0.68	GO:0042742	defense response to bacterium

0.85	GO:0003823	antigen binding
0.76	GO:0034987	immunoglobulin receptor binding
0.51	GO:0004252	serine-type endopeptidase activity

0.77	GO:0072562	blood microparticle
0.75	GO:0042571	immunoglobulin complex, circulating
0.71	GO:0009897	external side of plasma membrane
0.51	GO:0070062	extracellular exosome

0.51

GO:0004252

sp|P01766|HV313_HUMAN
Immunoglobulin heavy variable 3-13
Search

0.97	Immunoglobulin heavy variable 3-7

0.85	GO:0006958	complement activation, classical pathway
0.84	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.84	GO:0006909	phagocytosis
0.81	GO:0099024	plasma membrane invagination
0.80	GO:0050871	positive regulation of B cell activation
0.75	GO:0008037	cell recognition
0.74	GO:0045087	innate immune response
0.73	GO:0042742	defense response to bacterium
0.61	GO:0038094	Fc-gamma receptor signaling pathway
0.60	GO:0038095	Fc-epsilon receptor signaling pathway

0.85	GO:0003823	antigen binding
0.83	GO:0034987	immunoglobulin receptor binding
0.50	GO:0004252	serine-type endopeptidase activity

0.85	GO:0072562	blood microparticle
0.82	GO:0042571	immunoglobulin complex, circulating
0.77	GO:0009897	external side of plasma membrane
0.52	GO:0070062	extracellular exosome

0.50

GO:0004252

sp|P01767|HV353_HUMAN
Immunoglobulin heavy variable 3-53
Search

0.76	Immunoglobulin heavy variable 3-7

0.83	GO:0002250	adaptive immune response
0.77	GO:0002449	lymphocyte mediated immunity
0.77	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.77	GO:0006956	complement activation
0.77	GO:0006909	phagocytosis
0.70	GO:0099024	plasma membrane invagination
0.69	GO:0050871	positive regulation of B cell activation
0.66	GO:0008037	cell recognition
0.65	GO:0045087	innate immune response
0.64	GO:0038094	Fc-gamma receptor signaling pathway

0.85	GO:0003823	antigen binding
0.72	GO:0034987	immunoglobulin receptor binding
0.52	GO:0004252	serine-type endopeptidase activity

0.72	GO:0072562	blood microparticle
0.71	GO:0042571	immunoglobulin complex, circulating
0.67	GO:0009897	external side of plasma membrane
0.50	GO:0070062	extracellular exosome

0.52

GO:0004252

sp|P01768|HV330_HUMAN
Immunoglobulin heavy variable 3-30
Search

0.83	Immunoglobulin heavy variable 3-7

0.82	GO:0002250	adaptive immune response
0.76	GO:0002449	lymphocyte mediated immunity
0.76	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.76	GO:0006956	complement activation
0.75	GO:0006909	phagocytosis
0.68	GO:0038094	Fc-gamma receptor signaling pathway
0.68	GO:0038095	Fc-epsilon receptor signaling pathway
0.66	GO:0030449	regulation of complement activation
0.65	GO:0099024	plasma membrane invagination
0.64	GO:0050871	positive regulation of B cell activation

0.85	GO:0003823	antigen binding
0.66	GO:0034987	immunoglobulin receptor binding
0.54	GO:0004252	serine-type endopeptidase activity

0.67	GO:0072562	blood microparticle
0.66	GO:0042571	immunoglobulin complex, circulating
0.62	GO:0009897	external side of plasma membrane
0.50	GO:0070062	extracellular exosome

0.54

GO:0004252

sp|P01772|HV333_HUMAN
Immunoglobulin heavy variable 3-33
Search

0.81	Immunoglobulin heavy variable 3-7

0.82	GO:0002250	adaptive immune response
0.76	GO:0002449	lymphocyte mediated immunity
0.76	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.76	GO:0006956	complement activation
0.75	GO:0006909	phagocytosis
0.70	GO:0038094	Fc-gamma receptor signaling pathway
0.70	GO:0038095	Fc-epsilon receptor signaling pathway
0.68	GO:0030449	regulation of complement activation
0.65	GO:0050900	leukocyte migration
0.62	GO:0099024	plasma membrane invagination

0.85	GO:0003823	antigen binding
0.64	GO:0034987	immunoglobulin receptor binding
0.56	GO:0004252	serine-type endopeptidase activity

0.67	GO:0072562	blood microparticle
0.63	GO:0042571	immunoglobulin complex, circulating
0.60	GO:0009897	external side of plasma membrane
0.53	GO:0070062	extracellular exosome

0.56

GO:0004252

sp|P01780|HV307_HUMAN
Immunoglobulin heavy variable 3-7
Search

0.81	Immunoglobulin heavy variable 3-7

0.85	GO:0006958	complement activation, classical pathway
0.84	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.84	GO:0006909	phagocytosis
0.76	GO:0099024	plasma membrane invagination
0.76	GO:0050871	positive regulation of B cell activation
0.72	GO:0008037	cell recognition
0.70	GO:0045087	innate immune response
0.70	GO:0042742	defense response to bacterium
0.69	GO:0038094	Fc-gamma receptor signaling pathway
0.69	GO:0038095	Fc-epsilon receptor signaling pathway

0.85	GO:0003823	antigen binding
0.78	GO:0034987	immunoglobulin receptor binding
0.55	GO:0004252	serine-type endopeptidase activity

0.82	GO:0072562	blood microparticle
0.78	GO:0042571	immunoglobulin complex, circulating
0.73	GO:0009897	external side of plasma membrane
0.56	GO:0070062	extracellular exosome

0.55

GO:0004252

sp|P01782|HV309_HUMAN
Immunoglobulin heavy variable 3-9
Search

0.97	Immunoglobulin heavy variable 3-9

0.84	GO:0006958	complement activation, classical pathway
0.82	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.82	GO:0006909	phagocytosis
0.76	GO:0099024	plasma membrane invagination
0.75	GO:0050871	positive regulation of B cell activation
0.71	GO:0008037	cell recognition
0.70	GO:0045087	innate immune response
0.69	GO:0042742	defense response to bacterium
0.65	GO:0038094	Fc-gamma receptor signaling pathway
0.65	GO:0038095	Fc-epsilon receptor signaling pathway

0.85	GO:0003823	antigen binding
0.78	GO:0034987	immunoglobulin receptor binding
0.52	GO:0004252	serine-type endopeptidase activity

0.78	GO:0072562	blood microparticle
0.77	GO:0042571	immunoglobulin complex, circulating
0.72	GO:0009897	external side of plasma membrane
0.53	GO:0070062	extracellular exosome

0.52

GO:0004252

sp|P01814|HV270_HUMAN
Immunoglobulin heavy variable 2-70
Search

0.90	Ig heavy chain V-II region SESS

0.83	GO:0006958	complement activation, classical pathway
0.81	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.81	GO:0006910	phagocytosis, recognition
0.80	GO:0006911	phagocytosis, engulfment
0.79	GO:0050871	positive regulation of B cell activation
0.73	GO:0045087	innate immune response
0.72	GO:0042742	defense response to bacterium
0.51	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
0.50	GO:0038094	Fc-gamma receptor signaling pathway
0.50	GO:0038095	Fc-epsilon receptor signaling pathway

0.85	GO:0003823	antigen binding
0.82	GO:0034987	immunoglobulin receptor binding
0.43	GO:0004252	serine-type endopeptidase activity

0.81	GO:0042571	immunoglobulin complex, circulating
0.80	GO:0072562	blood microparticle
0.76	GO:0009897	external side of plasma membrane
0.38	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.43

GO:0004252

sp|P01817|HV205_HUMAN
Immunoglobulin heavy variable 2-5
Search

0.89	Ig heavy chain V-II region SESS

0.81	GO:0006958	complement activation, classical pathway
0.79	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.79	GO:0006910	phagocytosis, recognition
0.78	GO:0006911	phagocytosis, engulfment
0.77	GO:0050871	positive regulation of B cell activation
0.72	GO:0045087	innate immune response
0.71	GO:0009617	response to bacterium
0.69	GO:0098542	defense response to other organism
0.50	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
0.50	GO:0038094	Fc-gamma receptor signaling pathway

0.84	GO:0003823	antigen binding
0.80	GO:0034987	immunoglobulin receptor binding
0.43	GO:0004252	serine-type endopeptidase activity

0.79	GO:0042571	immunoglobulin complex, circulating
0.78	GO:0072562	blood microparticle
0.74	GO:0009897	external side of plasma membrane
0.30	GO:0016021	integral component of membrane

0.43

GO:0004252

sp|P01824|HV439_HUMAN
Immunoglobulin heavy variable 4-39
Search

0.87	Immunoglobulin heavy variable 4-4

0.83	GO:0002250	adaptive immune response
0.74	GO:0002449	lymphocyte mediated immunity
0.74	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.74	GO:0006956	complement activation
0.74	GO:0006909	phagocytosis
0.66	GO:0099024	plasma membrane invagination
0.65	GO:0050871	positive regulation of B cell activation
0.62	GO:0008037	cell recognition
0.62	GO:0038094	Fc-gamma receptor signaling pathway
0.62	GO:0038095	Fc-epsilon receptor signaling pathway

0.85	GO:0003823	antigen binding
0.67	GO:0034987	immunoglobulin receptor binding
0.50	GO:0004252	serine-type endopeptidase activity

0.67	GO:0042571	immunoglobulin complex, circulating
0.66	GO:0072562	blood microparticle
0.63	GO:0009897	external side of plasma membrane
0.45	GO:0070062	extracellular exosome

0.50

GO:0004252

sp|P01825|HV459_HUMAN
Immunoglobulin heavy variable 4-59
Search

0.88	Immunoglobulin heavy variable 4-4

0.83	GO:0002250	adaptive immune response
0.74	GO:0002449	lymphocyte mediated immunity
0.74	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.74	GO:0006956	complement activation
0.73	GO:0006909	phagocytosis
0.64	GO:0099024	plasma membrane invagination
0.64	GO:0050871	positive regulation of B cell activation
0.63	GO:0038094	Fc-gamma receptor signaling pathway
0.62	GO:0038095	Fc-epsilon receptor signaling pathway
0.61	GO:0030449	regulation of complement activation

0.85	GO:0003823	antigen binding
0.66	GO:0034987	immunoglobulin receptor binding
0.51	GO:0004252	serine-type endopeptidase activity

0.66	GO:0005576	extracellular region
0.65	GO:0019814	immunoglobulin complex
0.62	GO:0009897	external side of plasma membrane
0.44	GO:0031982	vesicle

0.51

GO:0004252

sp|P01833|PIGR_HUMAN
Polymeric immunoglobulin receptor
Search

PIGR

0.97	Polymeric immunoglobulin receptor

0.82	GO:0002415	immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
0.77	GO:0038093	Fc receptor signaling pathway
0.77	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
0.76	GO:0043113	receptor clustering
0.75	GO:0007173	epidermal growth factor receptor signaling pathway
0.45	GO:0001895	retina homeostasis
0.42	GO:0043312	neutrophil degranulation

0.83	GO:0001792	polymeric immunoglobulin receptor activity
0.40	GO:0005154	epidermal growth factor receptor binding

0.69	GO:0043235	receptor complex
0.65	GO:0005615	extracellular space
0.51	GO:0005886	plasma membrane
0.43	GO:1903561	extracellular vesicle
0.43	GO:0035577	azurophil granule membrane
0.39	GO:0055038	recycling endosome membrane
0.38	GO:0030133	transport vesicle
0.30	GO:0016021	integral component of membrane

sp|P01834|IGKC_HUMAN
Immunoglobulin kappa constant
Search

IGKC

0.97	Immunoglobulin kappa constant

0.66	GO:0006910	phagocytosis, recognition
0.65	GO:0006911	phagocytosis, engulfment
0.65	GO:0002250	adaptive immune response
0.65	GO:0050853	B cell receptor signaling pathway
0.65	GO:0050871	positive regulation of B cell activation
0.64	GO:0002449	lymphocyte mediated immunity
0.64	GO:0006956	complement activation
0.61	GO:0045087	innate immune response
0.60	GO:0042742	defense response to bacterium
0.51	GO:0002377	immunoglobulin production

0.71	GO:0003823	antigen binding
0.67	GO:0034987	immunoglobulin receptor binding
0.39	GO:0004252	serine-type endopeptidase activity
0.39	GO:0046872	metal ion binding

0.66	GO:0042571	immunoglobulin complex, circulating
0.65	GO:0072562	blood microparticle
0.62	GO:0009897	external side of plasma membrane
0.46	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.39

GO:0004252

sp|P01848|TCA_HUMAN
T-cell receptor alpha chain C region
Search

TRAC

0.97	T-cell receptor alpha constant

0.30

GO:0044425

membrane part

sp|P01850|TRBC1_HUMAN
T-cell receptor beta-1 chain C region
Search

0.96	T-cell receptor beta chain C region

0.63	GO:0006910	phagocytosis, recognition
0.62	GO:0006911	phagocytosis, engulfment
0.62	GO:0050853	B cell receptor signaling pathway
0.62	GO:0006958	complement activation, classical pathway
0.61	GO:0050871	positive regulation of B cell activation
0.58	GO:0045087	innate immune response
0.57	GO:0042742	defense response to bacterium
0.54	GO:0031295	T cell costimulation
0.53	GO:0050852	T cell receptor signaling pathway

0.63	GO:0034987	immunoglobulin receptor binding
0.62	GO:0003823	antigen binding

0.63	GO:0042571	immunoglobulin complex, circulating
0.62	GO:0072562	blood microparticle
0.59	GO:0009897	external side of plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P01854|IGHE_HUMAN
Immunoglobulin heavy constant epsilon
Search

IGHE

0.95	Immunoglobulin heavy constant epsilon

0.71	GO:0002250	adaptive immune response
0.71	GO:0006910	phagocytosis, recognition
0.71	GO:0006911	phagocytosis, engulfment
0.70	GO:0050853	B cell receptor signaling pathway
0.70	GO:0050871	positive regulation of B cell activation
0.69	GO:0002449	lymphocyte mediated immunity
0.69	GO:0006956	complement activation
0.65	GO:0045087	innate immune response
0.65	GO:0042742	defense response to bacterium
0.49	GO:0038095	Fc-epsilon receptor signaling pathway

0.76	GO:0003823	antigen binding
0.72	GO:0034987	immunoglobulin receptor binding
0.33	GO:0005509	calcium ion binding

0.72	GO:0042571	immunoglobulin complex, circulating
0.70	GO:0072562	blood microparticle
0.67	GO:0009897	external side of plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P01857|IGHG1_HUMAN
Immunoglobulin heavy constant gamma 1
Search

IGHG

0.96	IgG heavy chain

sp|P01859|IGHG2_HUMAN
Immunoglobulin heavy constant gamma 2
Search

IGHG

0.96	IgG heavy chain

sp|P01860|IGHG3_HUMAN
Immunoglobulin heavy constant gamma 3
Search

0.71	Ig gamma chain C region

0.49	GO:0006910	phagocytosis, recognition
0.49	GO:0006911	phagocytosis, engulfment
0.49	GO:0050853	B cell receptor signaling pathway
0.49	GO:0006958	complement activation, classical pathway
0.49	GO:0050871	positive regulation of B cell activation
0.46	GO:0045087	innate immune response
0.46	GO:0042742	defense response to bacterium

0.68	GO:0003823	antigen binding
0.64	GO:0034987	immunoglobulin receptor binding

0.51	GO:0005576	extracellular region
0.49	GO:0019814	immunoglobulin complex
0.47	GO:0009897	external side of plasma membrane
0.30	GO:0016021	integral component of membrane

sp|P01861|IGHG4_HUMAN
Immunoglobulin heavy constant gamma 4
Search

IGHG

0.97	IgG heavy chain

sp|P01871|IGHM_HUMAN
Immunoglobulin heavy constant mu
Search

IGHM

0.95	Immunoglobulin heavy constant mu

0.73	GO:0002250	adaptive immune response
0.70	GO:0006959	humoral immune response
0.68	GO:0045087	innate immune response
0.67	GO:0042742	defense response to bacterium
0.65	GO:0006910	phagocytosis, recognition
0.65	GO:0006911	phagocytosis, engulfment
0.65	GO:0050853	B cell receptor signaling pathway
0.64	GO:0050871	positive regulation of B cell activation
0.63	GO:0002449	lymphocyte mediated immunity
0.63	GO:0072376	protein activation cascade

0.75	GO:0034987	immunoglobulin receptor binding
0.67	GO:0003823	antigen binding
0.66	GO:0031210	phosphatidylcholine binding
0.59	GO:0042834	peptidoglycan binding
0.57	GO:0003697	single-stranded DNA binding

0.75	GO:0042571	immunoglobulin complex, circulating
0.69	GO:0071753	IgM immunoglobulin complex
0.65	GO:0009986	cell surface
0.65	GO:0072562	blood microparticle
0.58	GO:0098552	side of membrane
0.50	GO:0044459	plasma membrane part
0.43	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

sp|P01876|IGHA1_HUMAN
Immunoglobulin heavy constant alpha 1
Search

0.97	Immunoglobulin heavy constant alpha 1

0.76	GO:0002455	humoral immune response mediated by circulating immunoglobulin
0.68	GO:0006910	phagocytosis, recognition
0.68	GO:0006911	phagocytosis, engulfment
0.67	GO:0050853	B cell receptor signaling pathway
0.67	GO:0050871	positive regulation of B cell activation
0.66	GO:0006956	complement activation
0.62	GO:0045087	innate immune response
0.62	GO:0042742	defense response to bacterium
0.61	GO:0002385	mucosal immune response
0.56	GO:0060267	positive regulation of respiratory burst

0.84	GO:0003823	antigen binding
0.71	GO:0034987	immunoglobulin receptor binding

0.77	GO:0042571	immunoglobulin complex, circulating
0.68	GO:0072562	blood microparticle
0.64	GO:0009897	external side of plasma membrane
0.58	GO:0071745	IgA immunoglobulin complex
0.52	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

sp|P01877|IGHA2_HUMAN
Immunoglobulin heavy constant alpha 2
Search

0.50	Immunoglobulin heavy constant mu

0.77	GO:0002455	humoral immune response mediated by circulating immunoglobulin
0.71	GO:0006910	phagocytosis, recognition
0.71	GO:0006911	phagocytosis, engulfment
0.70	GO:0050853	B cell receptor signaling pathway
0.70	GO:0050871	positive regulation of B cell activation
0.69	GO:0006956	complement activation
0.65	GO:0045087	innate immune response
0.64	GO:0042742	defense response to bacterium
0.62	GO:0002385	mucosal immune response
0.54	GO:0060267	positive regulation of respiratory burst

0.84	GO:0003823	antigen binding
0.74	GO:0034987	immunoglobulin receptor binding

0.79	GO:0042571	immunoglobulin complex, circulating
0.71	GO:0072562	blood microparticle
0.67	GO:0009897	external side of plasma membrane
0.56	GO:0071745	IgA immunoglobulin complex
0.50	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

sp|P01880|IGHD_HUMAN
Immunoglobulin heavy constant delta
Search

IGHD

0.97	Immunoglobulin heavy constant delta

0.79	GO:0050716	positive regulation of interleukin-1 secretion
0.66	GO:0002250	adaptive immune response
0.58	GO:0042117	monocyte activation
0.58	GO:0050871	positive regulation of B cell activation
0.58	GO:0006910	phagocytosis, recognition
0.58	GO:0002449	lymphocyte mediated immunity
0.58	GO:1904469	positive regulation of tumor necrosis factor secretion
0.57	GO:0006911	phagocytosis, engulfment
0.57	GO:0050853	B cell receptor signaling pathway
0.56	GO:0032731	positive regulation of interleukin-1 beta production

0.68	GO:0003823	antigen binding
0.58	GO:0034987	immunoglobulin receptor binding

0.59	GO:0019814	immunoglobulin complex
0.58	GO:0005615	extracellular space
0.56	GO:0009897	external side of plasma membrane
0.53	GO:1903561	extracellular vesicle
0.42	GO:0098802	plasma membrane receptor complex
0.39	GO:0098797	plasma membrane protein complex
0.30	GO:0016021	integral component of membrane

sp|P01891|1A68_HUMAN
HLA class I histocompatibility antigen, A-68 alpha chain
Search

HLA-A

0.40	MHC class I antigen

0.80	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
0.72	GO:0006955	immune response
0.42	GO:0002478	antigen processing and presentation of exogenous peptide antigen
0.40	GO:0019221	cytokine-mediated signaling pathway
0.39	GO:0006952	defense response
0.39	GO:0050776	regulation of immune response
0.37	GO:0016032	viral process
0.37	GO:0002446	neutrophil mediated immunity
0.37	GO:0043299	leukocyte degranulation
0.37	GO:0042119	neutrophil activation

0.43	GO:0030881	beta-2-microglobulin binding
0.42	GO:0042605	peptide antigen binding
0.35	GO:0005102	receptor binding
0.35	GO:0003723	RNA binding

0.80	GO:0042612	MHC class I protein complex
0.42	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane
0.42	GO:0030670	phagocytic vesicle membrane
0.41	GO:0055038	recycling endosome membrane
0.41	GO:0031901	early endosome membrane
0.40	GO:0012507	ER to Golgi transport vesicle membrane
0.39	GO:0009986	cell surface
0.39	GO:0000139	Golgi membrane
0.36	GO:0030667	secretory granule membrane
0.36	GO:0070062	extracellular exosome

sp|P01893|HLAH_HUMAN
Putative HLA class I histocompatibility antigen, alpha chain H
Search

HLA-C

0.41	Major histocompatibility complex class I

0.80	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
0.73	GO:0006955	immune response
0.40	GO:0002478	antigen processing and presentation of exogenous peptide antigen
0.38	GO:0019221	cytokine-mediated signaling pathway
0.37	GO:0006952	defense response
0.37	GO:0050776	regulation of immune response
0.35	GO:0016032	viral process
0.35	GO:0002446	neutrophil mediated immunity
0.35	GO:0043299	leukocyte degranulation
0.35	GO:0042119	neutrophil activation

0.41	GO:0042605	peptide antigen binding
0.38	GO:0046977	TAP binding
0.35	GO:0030881	beta-2-microglobulin binding
0.35	GO:0005102	receptor binding

0.80	GO:0042612	MHC class I protein complex
0.40	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane
0.40	GO:0030670	phagocytic vesicle membrane
0.40	GO:0055038	recycling endosome membrane
0.39	GO:0031901	early endosome membrane
0.39	GO:0012507	ER to Golgi transport vesicle membrane
0.38	GO:0009986	cell surface
0.38	GO:0000139	Golgi membrane
0.35	GO:0035577	azurophil granule membrane
0.35	GO:0005887	integral component of plasma membrane

sp|P01903|DRA_HUMAN
HLA class II histocompatibility antigen, DR alpha chain
Search

0.42	Mamu class II histocompatibility antigen, DR alpha chain

0.83	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
0.74	GO:0006955	immune response
0.50	GO:0065006	protein-carbohydrate complex assembly
0.49	GO:0002399	MHC class II protein complex assembly
0.49	GO:0002501	peptide antigen assembly with MHC protein complex
0.46	GO:0050890	cognition
0.35	GO:0002478	antigen processing and presentation of exogenous peptide antigen
0.35	GO:0031295	T cell costimulation
0.35	GO:0050852	T cell receptor signaling pathway
0.34	GO:0019221	cytokine-mediated signaling pathway

0.48	GO:0042605	peptide antigen binding
0.36	GO:0032395	MHC class II receptor activity
0.35	GO:0023026	MHC class II protein complex binding

0.76	GO:0042613	MHC class II protein complex
0.46	GO:0031902	late endosome membrane
0.46	GO:0005765	lysosomal membrane
0.44	GO:0009986	cell surface
0.35	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane
0.35	GO:0032588	trans-Golgi network membrane
0.35	GO:0030669	clathrin-coated endocytic vesicle membrane
0.34	GO:0070062	extracellular exosome
0.34	GO:0012507	ER to Golgi transport vesicle membrane
0.33	GO:0005887	integral component of plasma membrane

sp|P01906|DQA2_HUMAN
HLA class II histocompatibility antigen, DQ alpha 2 chain
Search

0.43	Major histocompatibility complex class II DQ alpha chain

0.83	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
0.74	GO:0006955	immune response
0.37	GO:0002478	antigen processing and presentation of exogenous peptide antigen
0.35	GO:0034097	response to cytokine
0.35	GO:0050870	positive regulation of T cell activation
0.35	GO:0031294	lymphocyte costimulation
0.35	GO:0006952	defense response
0.35	GO:0050852	T cell receptor signaling pathway
0.34	GO:0045621	positive regulation of lymphocyte differentiation
0.34	GO:0045580	regulation of T cell differentiation

0.35	GO:0032395	MHC class II receptor activity
0.35	GO:0042605	peptide antigen binding

0.76	GO:0042613	MHC class II protein complex
0.35	GO:0005764	lysosome
0.35	GO:0098552	side of membrane
0.35	GO:0032588	trans-Golgi network membrane
0.35	GO:0030669	clathrin-coated endocytic vesicle membrane
0.34	GO:0012507	ER to Golgi transport vesicle membrane
0.34	GO:0098852	lytic vacuole membrane
0.34	GO:0010008	endosome membrane
0.34	GO:0030176	integral component of endoplasmic reticulum membrane
0.34	GO:0009986	cell surface

sp|P01909|DQA1_HUMAN
HLA class II histocompatibility antigen, DQ alpha 1 chain
Search

0.43	Major histocompatibility complex class II DQ alpha chain

0.82	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
0.73	GO:0006955	immune response
0.37	GO:0002478	antigen processing and presentation of exogenous peptide antigen
0.35	GO:0034097	response to cytokine
0.35	GO:0050870	positive regulation of T cell activation
0.35	GO:0031294	lymphocyte costimulation
0.35	GO:0006952	defense response
0.35	GO:0050852	T cell receptor signaling pathway
0.34	GO:0045621	positive regulation of lymphocyte differentiation
0.34	GO:0045580	regulation of T cell differentiation

0.37	GO:0042605	peptide antigen binding
0.35	GO:0032395	MHC class II receptor activity

0.75	GO:0042613	MHC class II protein complex
0.36	GO:0005764	lysosome
0.35	GO:0098552	side of membrane
0.35	GO:0032588	trans-Golgi network membrane
0.35	GO:0030669	clathrin-coated endocytic vesicle membrane
0.34	GO:0012507	ER to Golgi transport vesicle membrane
0.34	GO:0098852	lytic vacuole membrane
0.34	GO:0010008	endosome membrane
0.34	GO:0030176	integral component of endoplasmic reticulum membrane
0.34	GO:0009986	cell surface

sp|P01911|2B1F_HUMAN
HLA class II histocompatibility antigen, DRB1-15 beta chain
Search

HLA-DRB1

0.49	Major histocompatibility complex class II antigen DR beta chain

0.83	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
0.74	GO:0006955	immune response
0.61	GO:0002478	antigen processing and presentation of exogenous peptide antigen
0.61	GO:0031295	T cell costimulation
0.60	GO:0050852	T cell receptor signaling pathway
0.57	GO:2001179	regulation of interleukin-10 secretion
0.56	GO:0019221	cytokine-mediated signaling pathway
0.55	GO:0032673	regulation of interleukin-4 production
0.55	GO:0032689	negative regulation of interferon-gamma production
0.55	GO:0016045	detection of bacterium

0.62	GO:0042605	peptide antigen binding
0.57	GO:0023026	MHC class II protein complex binding
0.50	GO:0032395	MHC class II receptor activity
0.48	GO:0104005	hijacked molecular function

0.76	GO:0042613	MHC class II protein complex
0.61	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane
0.60	GO:0032588	trans-Golgi network membrane
0.59	GO:0030669	clathrin-coated endocytic vesicle membrane
0.58	GO:0031902	late endosome membrane
0.57	GO:0005765	lysosomal membrane
0.56	GO:0012507	ER to Golgi transport vesicle membrane
0.54	GO:0009986	cell surface
0.52	GO:0070062	extracellular exosome

sp|P01920|DQB1_HUMAN
HLA class II histocompatibility antigen, DQ beta 1 chain
Search

HLA-DQB1

0.52	HLA class II histocompatibility antigen, DQ beta 1 chain

0.82	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
0.74	GO:0006955	immune response
0.50	GO:0002478	antigen processing and presentation of exogenous peptide antigen
0.50	GO:0031295	T cell costimulation
0.49	GO:0050852	T cell receptor signaling pathway
0.49	GO:0002377	immunoglobulin production
0.48	GO:0002449	lymphocyte mediated immunity
0.47	GO:0019221	cytokine-mediated signaling pathway
0.44	GO:0006952	defense response

0.52	GO:0032395	MHC class II receptor activity
0.50	GO:0042605	peptide antigen binding
0.38	GO:0046872	metal ion binding

0.76	GO:0042613	MHC class II protein complex
0.50	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane
0.49	GO:0032588	trans-Golgi network membrane
0.48	GO:0030669	clathrin-coated endocytic vesicle membrane
0.47	GO:0005765	lysosomal membrane
0.47	GO:0012507	ER to Golgi transport vesicle membrane
0.46	GO:0010008	endosome membrane

sp|P02008|HBAZ_HUMAN
Hemoglobin subunit zeta
Search

HBZ

0.96	Hemoglobin subunit zeta

0.79	GO:0015671	oxygen transport
0.47	GO:0043249	erythrocyte maturation
0.43	GO:0000122	negative regulation of transcription by RNA polymerase II
0.34	GO:0051291	protein heterooligomerization
0.34	GO:0042542	response to hydrogen peroxide
0.34	GO:0010942	positive regulation of cell death
0.34	GO:0042744	hydrogen peroxide catabolic process
0.33	GO:0015701	bicarbonate transport
0.33	GO:0098869	cellular oxidant detoxification
0.33	GO:0006898	receptor-mediated endocytosis

0.80	GO:0005344	oxygen carrier activity
0.79	GO:0019825	oxygen binding
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.35	GO:0031720	haptoglobin binding
0.33	GO:0004601	peroxidase activity

0.83	GO:0005833	hemoglobin complex
0.36	GO:0070062	extracellular exosome
0.35	GO:0031838	haptoglobin-hemoglobin complex
0.34	GO:0022627	cytosolic small ribosomal subunit
0.34	GO:0071682	endocytic vesicle lumen
0.33	GO:0072562	blood microparticle
0.30	GO:0016020	membrane

0.33	EC:1.11.1.7	GO:0004601
0.33	KEGG:R03532	GO:0004601

sp|P02042|HBD_HUMAN
Hemoglobin subunit delta
Search

HBB

0.83	Hemoglobin subunit delta

0.79	GO:0015671	oxygen transport
0.44	GO:0070293	renal absorption
0.43	GO:0051291	protein heterooligomerization
0.43	GO:0042542	response to hydrogen peroxide
0.41	GO:0010942	positive regulation of cell death
0.41	GO:0042744	hydrogen peroxide catabolic process
0.39	GO:0098869	cellular oxidant detoxification
0.36	GO:0007596	blood coagulation
0.35	GO:0030185	nitric oxide transport
0.35	GO:0043312	neutrophil degranulation

0.80	GO:0005344	oxygen carrier activity
0.79	GO:0019825	oxygen binding
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.46	GO:0031720	haptoglobin binding
0.44	GO:0030492	hemoglobin binding
0.40	GO:0004601	peroxidase activity

0.83	GO:0005833	hemoglobin complex
0.45	GO:0031838	haptoglobin-hemoglobin complex
0.41	GO:0005615	extracellular space
0.35	GO:0071682	endocytic vesicle lumen
0.35	GO:1904724	tertiary granule lumen
0.35	GO:1904813	ficolin-1-rich granule lumen
0.34	GO:1903561	extracellular vesicle

0.40	EC:1.11.1.7	GO:0004601
0.40	KEGG:R03532	GO:0004601

sp|P02100|HBE_HUMAN
Hemoglobin subunit epsilon
Search

HBE1

0.83	Hemoglobin subunit epsilon

0.79	GO:0015671	oxygen transport
0.40	GO:0051291	protein heterooligomerization
0.37	GO:0070293	renal absorption
0.37	GO:0000122	negative regulation of transcription by RNA polymerase II
0.37	GO:0007596	blood coagulation
0.37	GO:0042542	response to hydrogen peroxide
0.36	GO:0014070	response to organic cyclic compound
0.36	GO:0010942	positive regulation of cell death
0.36	GO:0042744	hydrogen peroxide catabolic process
0.35	GO:0098869	cellular oxidant detoxification

0.80	GO:0005344	oxygen carrier activity
0.79	GO:0019825	oxygen binding
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.40	GO:0030492	hemoglobin binding
0.38	GO:0031720	haptoglobin binding
0.35	GO:0004601	peroxidase activity
0.34	GO:0004984	olfactory receptor activity
0.33	GO:0004930	G-protein coupled receptor activity

0.83	GO:0005833	hemoglobin complex
0.38	GO:0031838	haptoglobin-hemoglobin complex
0.38	GO:0005615	extracellular space
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.35	EC:1.11.1.7	GO:0004601
0.35	KEGG:R03532	GO:0004601

sp|P02144|MYG_HUMAN
Myoglobin
Search

0.84

Myoglobin

0.79	GO:0015671	oxygen transport
0.46	GO:0043353	enucleate erythrocyte differentiation
0.44	GO:0050873	brown fat cell differentiation
0.44	GO:0001666	response to hypoxia
0.43	GO:0007507	heart development
0.41	GO:0031444	slow-twitch skeletal muscle fiber contraction
0.39	GO:0042542	response to hydrogen peroxide
0.38	GO:0009725	response to hormone

0.80	GO:0005344	oxygen carrier activity
0.79	GO:0019825	oxygen binding
0.63	GO:0020037	heme binding
0.54	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.36	GO:0070062	extracellular exosome
0.33	GO:0005829	cytosol

sp|P02452|CO1A1_HUMAN
Collagen alpha-1(I) chain
Search

COL1A1

0.80	Collagen type II alpha 1 chain

0.62	GO:0030199	collagen fibril organization
0.62	GO:0001958	endochondral ossification
0.62	GO:0060351	cartilage development involved in endochondral bone morphogenesis
0.61	GO:0032964	collagen biosynthetic process
0.60	GO:0034505	tooth mineralization
0.60	GO:0043589	skin morphogenesis
0.60	GO:0048706	embryonic skeletal system development
0.60	GO:0001957	intramembranous ossification
0.59	GO:0007605	sensory perception of sound
0.59	GO:0060346	bone trabecula formation

0.79	GO:0005201	extracellular matrix structural constituent
0.64	GO:0048407	platelet-derived growth factor binding
0.57	GO:0002020	protease binding
0.55	GO:0042802	identical protein binding
0.47	GO:0042289	MHC class II protein binding
0.37	GO:0046872	metal ion binding

0.73	GO:0005581	collagen trimer
0.64	GO:0098643	banded collagen fibril
0.56	GO:0005615	extracellular space
0.44	GO:0005604	basement membrane
0.40	GO:0005737	cytoplasm
0.38	GO:0097708	intracellular vesicle
0.38	GO:0012505	endomembrane system
0.35	GO:0043231	intracellular membrane-bounded organelle
0.34	GO:0070013	intracellular organelle lumen
0.33	GO:0044446	intracellular organelle part

sp|P02458|CO2A1_HUMAN
Collagen alpha-1(II) chain
Search

COL2A1

0.87	Collagen type II alpha 1 chain

0.65	GO:0060272	embryonic skeletal joint morphogenesis
0.64	GO:0060174	limb bud formation
0.63	GO:0001502	cartilage condensation
0.63	GO:0030199	collagen fibril organization
0.63	GO:0071599	otic vesicle development
0.63	GO:0001958	endochondral ossification
0.63	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
0.63	GO:0060351	cartilage development involved in endochondral bone morphogenesis
0.63	GO:0030903	notochord development
0.61	GO:0002062	chondrocyte differentiation

0.80	GO:0005201	extracellular matrix structural constituent
0.65	GO:0048407	platelet-derived growth factor binding
0.65	GO:0042289	MHC class II protein binding
0.55	GO:0042802	identical protein binding
0.37	GO:0046872	metal ion binding

0.74	GO:0005581	collagen trimer
0.65	GO:0098643	banded collagen fibril
0.59	GO:0005604	basement membrane
0.55	GO:0005615	extracellular space
0.41	GO:0005737	cytoplasm
0.35	GO:0012505	endomembrane system
0.35	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part
0.34	GO:0043231	intracellular membrane-bounded organelle

sp|P02461|CO3A1_HUMAN
Collagen alpha-1(III) chain
Search

COL3A1

0.80	Collagen type III alpha 1 chain

0.65	GO:0030199	collagen fibril organization
0.63	GO:0043588	skin development
0.62	GO:0071230	cellular response to amino acid stimulus
0.62	GO:0060414	aorta smooth muscle tissue morphogenesis
0.61	GO:2001223	negative regulation of neuron migration
0.60	GO:0035025	positive regulation of Rho protein signal transduction
0.59	GO:0060322	head development
0.59	GO:0018149	peptide cross-linking
0.58	GO:0071560	cellular response to transforming growth factor beta stimulus
0.57	GO:0007160	cell-matrix adhesion

0.80	GO:0005201	extracellular matrix structural constituent
0.67	GO:0048407	platelet-derived growth factor binding
0.64	GO:0002020	protease binding
0.59	GO:0005178	integrin binding
0.58	GO:0046332	SMAD binding
0.44	GO:0042802	identical protein binding
0.36	GO:0046872	metal ion binding

0.73	GO:0005581	collagen trimer
0.67	GO:0098643	banded collagen fibril
0.57	GO:0005615	extracellular space
0.38	GO:0005788	endoplasmic reticulum lumen
0.35	GO:0030141	secretory granule
0.34	GO:0005794	Golgi apparatus
0.30	GO:0016020	membrane

sp|P02462|CO4A1_HUMAN
Collagen alpha-1(IV) chain
Search

COL4A1

0.81	Collagen type IV alpha 1 chain

0.59	GO:0061304	retinal blood vessel morphogenesis
0.59	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
0.58	GO:0071711	basement membrane organization
0.58	GO:0007528	neuromuscular junction development
0.57	GO:0001569	branching involved in blood vessel morphogenesis
0.56	GO:0061333	renal tubule morphogenesis
0.56	GO:0071230	cellular response to amino acid stimulus
0.53	GO:0007420	brain development
0.40	GO:0030154	cell differentiation
0.38	GO:0060560	developmental growth involved in morphogenesis

0.81	GO:0005201	extracellular matrix structural constituent
0.58	GO:0048407	platelet-derived growth factor binding
0.37	GO:0097493	structural molecule activity conferring elasticity

0.82	GO:0005604	basement membrane
0.79	GO:0005581	collagen trimer
0.61	GO:0098645	collagen network
0.50	GO:0005615	extracellular space
0.40	GO:0031594	neuromuscular junction
0.36	GO:0005788	endoplasmic reticulum lumen

sp|P02489|CRYAA_HUMAN
Alpha-crystallin A chain
Search

CRYAA

0.97	Alpha crystallin A chain

0.53	GO:0070309	lens fiber cell morphogenesis
0.53	GO:0070141	response to UV-A
0.52	GO:0060561	apoptotic process involved in morphogenesis
0.52	GO:0048596	embryonic camera-type eye morphogenesis
0.51	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.50	GO:0007021	tubulin complex assembly
0.50	GO:0042542	response to hydrogen peroxide
0.50	GO:0030307	positive regulation of cell growth
0.50	GO:0001666	response to hypoxia
0.48	GO:0001934	positive regulation of protein phosphorylation

0.85	GO:0005212	structural constituent of eye lens
0.44	GO:0046872	metal ion binding
0.39	GO:0051082	unfolded protein binding
0.35	GO:0042802	identical protein binding

0.47	GO:0005634	nucleus
0.42	GO:0005737	cytoplasm
0.36	GO:0043233	organelle lumen
0.36	GO:0070062	extracellular exosome
0.35	GO:0044446	intracellular organelle part

sp|P02511|CRYAB_HUMAN
Alpha-crystallin B chain
Search

CRYAB

0.96	Alpha-crystallin B chain

0.62	GO:1905907	negative regulation of amyloid fibril formation
0.61	GO:0032463	negative regulation of protein homooligomerization
0.60	GO:0060561	apoptotic process involved in morphogenesis
0.59	GO:0071480	cellular response to gamma radiation
0.59	GO:0032387	negative regulation of intracellular transport
0.58	GO:0002088	lens development in camera-type eye
0.58	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.58	GO:0007021	tubulin complex assembly
0.57	GO:0042542	response to hydrogen peroxide
0.57	GO:0001666	response to hypoxia

0.83	GO:0005212	structural constituent of eye lens
0.59	GO:0001540	amyloid-beta binding
0.55	GO:0042803	protein homodimerization activity
0.53	GO:0032403	protein complex binding
0.51	GO:0051082	unfolded protein binding
0.39	GO:0008017	microtubule binding
0.38	GO:0046872	metal ion binding
0.36	GO:0008426	protein kinase C inhibitor activity
0.35	GO:0005080	protein kinase C binding
0.35	GO:0044183	protein binding involved in protein folding

0.58	GO:0030018	Z disc
0.57	GO:0043209	myelin sheath
0.50	GO:0005829	cytosol
0.47	GO:0005634	nucleus
0.46	GO:0005739	mitochondrion
0.43	GO:0005886	plasma membrane
0.42	GO:0097512	cardiac myofibril
0.41	GO:0031430	M band
0.41	GO:0043204	perikaryon
0.41	GO:0043197	dendritic spine

0.33

EC:2.4

GO:0016757

sp|P02533|K1C14_HUMAN
Keratin, type I cytoskeletal 14
Search

0.91	Putative nuclear envelope protein lamin intermediate filament superfamily

0.62	GO:0042633	hair cycle
0.61	GO:0045104	intermediate filament cytoskeleton organization
0.57	GO:0030855	epithelial cell differentiation
0.55	GO:0007568	aging
0.52	GO:0043588	skin development
0.52	GO:0008544	epidermis development
0.51	GO:0097435	supramolecular fiber organization
0.50	GO:0002009	morphogenesis of an epithelium
0.48	GO:0051546	keratinocyte migration
0.47	GO:0030336	negative regulation of cell migration

0.62	GO:0005198	structural molecule activity
0.54	GO:1990254	keratin filament binding
0.50	GO:0032395	MHC class II receptor activity
0.48	GO:0042289	MHC class II protein binding

0.79	GO:0005882	intermediate filament
0.51	GO:0045178	basal part of cell
0.42	GO:0005634	nucleus
0.42	GO:0071944	cell periphery
0.40	GO:0070062	extracellular exosome
0.39	GO:0005737	cytoplasm
0.35	GO:0036338	viral membrane

sp|P02538|K2C6A_HUMAN
Keratin, type II cytoskeletal 6A
Search

KRT5

0.89	Keratin, type II cytoskeletal 5

0.47	GO:0002244	hematopoietic progenitor cell differentiation
0.42	GO:0031424	keratinization
0.39	GO:0051803	negative regulation of cytolysis in other organism involved in symbiotic interaction
0.39	GO:0001898	regulation of cytolysis by symbiont of host cells
0.39	GO:0012501	programmed cell death
0.39	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
0.39	GO:0007010	cytoskeleton organization
0.39	GO:0045103	intermediate filament-based process
0.38	GO:2000536	negative regulation of entry of bacterium into host cell
0.38	GO:0050830	defense response to Gram-positive bacterium

0.62	GO:0005198	structural molecule activity
0.50	GO:0097110	scaffold protein binding

0.83	GO:0045095	keratin filament
0.41	GO:0070062	extracellular exosome
0.40	GO:0005739	mitochondrion
0.39	GO:0005886	plasma membrane
0.37	GO:0005829	cytosol
0.35	GO:0005634	nucleus
0.33	GO:0036338	viral membrane

sp|P02545|LMNA_HUMAN
Prelamin-A/C
Search

LMNA

0.95	Lamin A/C transcript variant 1

0.62	GO:0035105	sterol regulatory element binding protein import into nucleus
0.61	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress
0.60	GO:0090343	positive regulation of cell aging
0.60	GO:0072201	negative regulation of mesenchymal cell proliferation
0.59	GO:0055015	ventricular cardiac muscle cell development
0.59	GO:0090201	negative regulation of release of cytochrome c from mitochondria
0.58	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity
0.57	GO:0071456	cellular response to hypoxia
0.57	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
0.56	GO:0006998	nuclear envelope organization

0.62	GO:0005198	structural molecule activity
0.37	GO:0042802	identical protein binding
0.36	GO:0008157	protein phosphatase 1 binding
0.32	GO:0003676	nucleic acid binding

0.79	GO:0005882	intermediate filament
0.59	GO:0005652	nuclear lamina
0.54	GO:0031965	nuclear membrane
0.50	GO:0005654	nucleoplasm
0.38	GO:0048471	perinuclear region of cytoplasm
0.38	GO:0031012	extracellular matrix
0.35	GO:0016363	nuclear matrix
0.34	GO:0005829	cytosol
0.34	GO:0019031	viral envelope

sp|P02549|SPTA1_HUMAN
Spectrin alpha chain, erythrocytic 1
Search

SPTA1

0.83	Spectrin alpha chain, erythrocytic 1

0.70	GO:0002260	lymphocyte homeostasis
0.69	GO:0042102	positive regulation of T cell proliferation
0.69	GO:0032092	positive regulation of protein binding
0.67	GO:0007009	plasma membrane organization
0.65	GO:0030097	hemopoiesis
0.61	GO:0030036	actin cytoskeleton organization
0.59	GO:0006779	porphyrin-containing compound biosynthetic process
0.58	GO:0008360	regulation of cell shape
0.39	GO:0051693	actin filament capping
0.36	GO:0007411	axon guidance

0.70	GO:0005509	calcium ion binding
0.61	GO:0046982	protein heterodimerization activity
0.37	GO:0003779	actin binding
0.36	GO:0045296	cadherin binding
0.36	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.36	GO:0005200	structural constituent of cytoskeleton
0.35	GO:0032403	protein complex binding
0.34	GO:0004984	olfactory receptor activity
0.34	GO:0004930	G-protein coupled receptor activity

0.74	GO:0014731	spectrin-associated cytoskeleton
0.74	GO:0032437	cuticular plate
0.70	GO:0008091	spectrin
0.40	GO:0030424	axon
0.39	GO:0009898	cytoplasmic side of plasma membrane
0.35	GO:0015630	microtubule cytoskeleton
0.35	GO:0005829	cytosol
0.34	GO:0031226	intrinsic component of plasma membrane
0.33	GO:0043231	intracellular membrane-bounded organelle
0.32	GO:0012505	endomembrane system

sp|P02585|TNNC2_HUMAN
Troponin C, skeletal muscle
Search

TNNC2

0.94	Fast skeletal muscle troponin C

0.55	GO:0006941	striated muscle contraction
0.54	GO:0050881	musculoskeletal movement
0.48	GO:0006937	regulation of muscle contraction
0.43	GO:0014823	response to activity
0.41	GO:0060047	heart contraction
0.41	GO:0003231	cardiac ventricle development
0.41	GO:0003229	ventricular cardiac muscle tissue development
0.41	GO:0055008	cardiac muscle tissue morphogenesis
0.41	GO:0014883	transition between fast and slow fiber
0.41	GO:0003206	cardiac chamber morphogenesis

0.70	GO:0005509	calcium ion binding
0.50	GO:0048306	calcium-dependent protein binding
0.50	GO:0003779	actin binding
0.46	GO:0032403	protein complex binding
0.43	GO:0031014	troponin T binding
0.42	GO:0031013	troponin I binding
0.39	GO:0042803	protein homodimerization activity
0.34	GO:0047617	acyl-CoA hydrolase activity

0.55	GO:0036379	myofilament
0.53	GO:0030017	sarcomere
0.50	GO:0015629	actin cytoskeleton
0.48	GO:0044430	cytoskeletal part
0.44	GO:0043234	protein complex
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.34

EC:3.1.2 EC:3.1.2.20

GO:0047617

sp|P02647|APOA1_HUMAN
Apolipoprotein A-I
Search

APOA1

0.97	apolipoprotein A-I precursor

0.74	GO:0042157	lipoprotein metabolic process
0.74	GO:0006869	lipid transport
0.71	GO:0008203	cholesterol metabolic process
0.70	GO:0030300	regulation of intestinal cholesterol absorption
0.70	GO:0060354	negative regulation of cell adhesion molecule production
0.70	GO:0034380	high-density lipoprotein particle assembly
0.70	GO:0010873	positive regulation of cholesterol esterification
0.69	GO:0018158	protein oxidation
0.69	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling
0.68	GO:0034369	plasma lipoprotein particle remodeling

0.72	GO:0008289	lipid binding
0.71	GO:0070653	high-density lipoprotein particle receptor binding
0.70	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity
0.69	GO:0008035	high-density lipoprotein particle binding
0.68	GO:0034191	apolipoprotein A-I receptor binding
0.68	GO:0017127	cholesterol transporter activity
0.67	GO:0045499	chemorepellent activity
0.65	GO:0001540	amyloid-beta binding
0.64	GO:0043178	alcohol binding
0.59	GO:0031072	heat shock protein binding

0.74	GO:0034364	high-density lipoprotein particle
0.66	GO:0034385	triglyceride-rich plasma lipoprotein particle
0.61	GO:0030139	endocytic vesicle
0.57	GO:0031012	extracellular matrix
0.51	GO:0042627	chylomicron
0.50	GO:0072562	blood microparticle
0.42	GO:0034362	low-density lipoprotein particle
0.39	GO:0009986	cell surface
0.38	GO:0070062	extracellular exosome
0.37	GO:0034774	secretory granule lumen

sp|P02649|APOE_HUMAN
Apolipoprotein E
Search

APOE

0.97	Apolipoprotein E

0.74	GO:0042157	lipoprotein metabolic process
0.73	GO:0006869	lipid transport
0.68	GO:1903000	regulation of lipid transport across blood brain barrier
0.68	GO:1905860	positive regulation of heparan sulfate proteoglycan binding
0.68	GO:1905890	regulation of cellular response to very-low-density lipoprotein particle stimulus
0.68	GO:1901630	negative regulation of presynaptic membrane organization
0.68	GO:1905853	regulation of heparan sulfate binding
0.68	GO:0034372	very-low-density lipoprotein particle remodeling
0.68	GO:1902994	regulation of phospholipid efflux
0.68	GO:0010873	positive regulation of cholesterol esterification

0.71	GO:0008289	lipid binding
0.70	GO:0008201	heparin binding
0.68	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity
0.68	GO:0070326	very-low-density lipoprotein particle receptor binding
0.68	GO:0046911	metal chelating activity
0.67	GO:0001540	amyloid-beta binding
0.66	GO:0048156	tau protein binding
0.65	GO:0050750	low-density lipoprotein particle receptor binding
0.65	GO:0017127	cholesterol transporter activity
0.64	GO:0071814	protein-lipid complex binding

0.75	GO:0042627	chylomicron
0.75	GO:0034385	triglyceride-rich plasma lipoprotein particle
0.74	GO:0034364	high-density lipoprotein particle
0.66	GO:0034362	low-density lipoprotein particle
0.65	GO:0106003	amyloid-beta complex
0.55	GO:0031012	extracellular matrix
0.54	GO:0005794	Golgi apparatus
0.53	GO:0005783	endoplasmic reticulum
0.46	GO:0072562	blood microparticle
0.45	GO:0005886	plasma membrane

sp|P02652|APOA2_HUMAN
Apolipoprotein A-II
Search

APOA2

0.97	Apolipoprotein A-II

0.75	GO:0042157	lipoprotein metabolic process
0.74	GO:0006869	lipid transport
0.70	GO:0060695	negative regulation of cholesterol transporter activity
0.70	GO:0018158	protein oxidation
0.70	GO:0045416	positive regulation of interleukin-8 biosynthetic process
0.69	GO:0060621	negative regulation of cholesterol import
0.69	GO:0034380	high-density lipoprotein particle assembly
0.69	GO:0034374	low-density lipoprotein particle remodeling
0.69	GO:0034370	triglyceride-rich lipoprotein particle remodeling
0.69	GO:0060192	negative regulation of lipase activity

0.72	GO:0008289	lipid binding
0.71	GO:0070653	high-density lipoprotein particle receptor binding
0.70	GO:0034190	apolipoprotein receptor binding
0.69	GO:0008035	high-density lipoprotein particle binding
0.68	GO:0050997	quaternary ammonium group binding
0.68	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity
0.67	GO:0055102	lipase inhibitor activity
0.67	GO:0017127	cholesterol transporter activity
0.64	GO:0070405	ammonium ion binding
0.64	GO:0043178	alcohol binding

0.75	GO:0034364	high-density lipoprotein particle
0.67	GO:0042627	chylomicron
0.67	GO:0034361	very-low-density lipoprotein particle
0.53	GO:0072562	blood microparticle
0.39	GO:0070062	extracellular exosome
0.38	GO:0005788	endoplasmic reticulum lumen
0.37	GO:0005769	early endosome
0.37	GO:0005829	cytosol

sp|P02654|APOC1_HUMAN
Apolipoprotein C-I
Search

APOC1

0.97	Apolipoprotein C-I, acidic form

0.75	GO:0042157	lipoprotein metabolic process
0.67	GO:0006869	lipid transport
0.63	GO:0010900	negative regulation of phosphatidylcholine catabolic process
0.62	GO:0034447	very-low-density lipoprotein particle clearance
0.61	GO:0010915	regulation of very-low-density lipoprotein particle clearance
0.61	GO:0071830	triglyceride-rich lipoprotein particle clearance
0.61	GO:0051005	negative regulation of lipoprotein lipase activity
0.61	GO:0010985	negative regulation of lipoprotein particle clearance
0.60	GO:0032375	negative regulation of cholesterol transport
0.60	GO:0048261	negative regulation of receptor-mediated endocytosis

0.59	GO:0004859	phospholipase inhibitor activity
0.58	GO:0005504	fatty acid binding
0.40	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity
0.40	GO:0031210	phosphatidylcholine binding

0.67	GO:0034361	very-low-density lipoprotein particle
0.58	GO:0034364	high-density lipoprotein particle
0.49	GO:0005783	endoplasmic reticulum
0.41	GO:0070062	extracellular exosome
0.40	GO:0042627	chylomicron

sp|P02655|APOC2_HUMAN
Apolipoprotein C-II
Search

APOC2

0.97	Apolipoprotein C-II

0.74	GO:0006869	lipid transport
0.73	GO:0043085	positive regulation of catalytic activity
0.69	GO:0060697	positive regulation of phospholipid catabolic process
0.68	GO:0010915	regulation of very-low-density lipoprotein particle clearance
0.68	GO:0071830	triglyceride-rich lipoprotein particle clearance
0.68	GO:0034384	high-density lipoprotein particle clearance
0.67	GO:0010985	negative regulation of lipoprotein particle clearance
0.67	GO:0032375	negative regulation of cholesterol transport
0.66	GO:0048261	negative regulation of receptor-mediated endocytosis
0.66	GO:0051004	regulation of lipoprotein lipase activity

0.75	GO:0008047	enzyme activator activity
0.67	GO:0043274	phospholipase binding
0.65	GO:0055102	lipase inhibitor activity
0.57	GO:0042803	protein homodimerization activity
0.55	GO:0008289	lipid binding

0.86	GO:0042627	chylomicron
0.77	GO:0034362	low-density lipoprotein particle
0.74	GO:0034361	very-low-density lipoprotein particle
0.74	GO:0034364	high-density lipoprotein particle
0.67	GO:0034363	intermediate-density lipoprotein particle
0.41	GO:0070062	extracellular exosome
0.39	GO:0005769	early endosome
0.35	GO:0005829	cytosol

sp|P02656|APOC3_HUMAN
Apolipoprotein C-III
Search

APOC3

0.97	Apolipoprotein C-III

0.80	GO:0010987	negative regulation of high-density lipoprotein particle clearance
0.79	GO:0010897	negative regulation of triglyceride catabolic process
0.78	GO:0010989	negative regulation of low-density lipoprotein particle clearance
0.78	GO:0010915	regulation of very-low-density lipoprotein particle clearance
0.77	GO:0060621	negative regulation of cholesterol import
0.77	GO:0051005	negative regulation of lipoprotein lipase activity
0.76	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling
0.76	GO:0071830	triglyceride-rich lipoprotein particle clearance
0.75	GO:0042157	lipoprotein metabolic process
0.75	GO:0032489	regulation of Cdc42 protein signal transduction

0.78	GO:0070653	high-density lipoprotein particle receptor binding
0.74	GO:0055102	lipase inhibitor activity
0.72	GO:0008289	lipid binding
0.47	GO:0043168	anion binding
0.40	GO:0043178	alcohol binding
0.33	GO:0097159	organic cyclic compound binding

0.77	GO:0034363	intermediate-density lipoprotein particle
0.76	GO:0034366	spherical high-density lipoprotein particle
0.75	GO:0042627	chylomicron
0.75	GO:0034361	very-low-density lipoprotein particle
0.62	GO:0031012	extracellular matrix
0.39	GO:0070062	extracellular exosome
0.39	GO:0005769	early endosome
0.36	GO:0005829	cytosol

sp|P02671|FIBA_HUMAN
Fibrinogen alpha chain
Search

FGA

0.74	Fibrinogen alpha chain

0.81	GO:0007596	blood coagulation
0.74	GO:0001775	cell activation
0.72	GO:0051258	protein polymerization
0.62	GO:0043152	induction of bacterial agglutination
0.61	GO:0034116	positive regulation of heterotypic cell-cell adhesion
0.61	GO:0042730	fibrinolysis
0.60	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
0.60	GO:0045907	positive regulation of vasoconstriction
0.60	GO:2000352	negative regulation of endothelial cell apoptotic process
0.60	GO:0031639	plasminogen activation

0.75	GO:0030674	protein binding, bridging
0.68	GO:0005102	receptor binding
0.56	GO:0050839	cell adhesion molecule binding
0.46	GO:0005198	structural molecule activity
0.34	GO:0046872	metal ion binding

0.82	GO:0005577	fibrinogen complex
0.60	GO:0031091	platelet alpha granule
0.57	GO:0009897	external side of plasma membrane
0.54	GO:0005938	cell cortex
0.36	GO:0072562	blood microparticle
0.35	GO:0070062	extracellular exosome
0.35	GO:0005791	rough endoplasmic reticulum
0.33	GO:0034774	secretory granule lumen
0.33	GO:0005788	endoplasmic reticulum lumen
0.30	GO:0016021	integral component of membrane

sp|P02675|FIBB_HUMAN
Fibrinogen beta chain
Search

FGB

0.71	Fibrinogen beta chain

0.82	GO:0007596	blood coagulation
0.77	GO:0001775	cell activation
0.75	GO:0051258	protein polymerization
0.63	GO:0043152	induction of bacterial agglutination
0.62	GO:0034116	positive regulation of heterotypic cell-cell adhesion
0.61	GO:0042730	fibrinolysis
0.61	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
0.61	GO:0045907	positive regulation of vasoconstriction
0.60	GO:2000352	negative regulation of endothelial cell apoptotic process
0.60	GO:0031639	plasminogen activation

0.78	GO:0030674	protein binding, bridging
0.70	GO:0005102	receptor binding
0.56	GO:0050839	cell adhesion molecule binding
0.55	GO:0051087	chaperone binding
0.47	GO:0005198	structural molecule activity
0.32	GO:0046872	metal ion binding

0.85	GO:0005577	fibrinogen complex
0.61	GO:0031091	platelet alpha granule
0.57	GO:0009897	external side of plasma membrane
0.55	GO:0005938	cell cortex
0.52	GO:0005783	endoplasmic reticulum
0.41	GO:0072562	blood microparticle
0.37	GO:0070062	extracellular exosome
0.36	GO:0034774	secretory granule lumen

sp|P02679|FIBG_HUMAN
Fibrinogen gamma chain
Search

FGG

0.97	Fibrinogen gamma polypeptide

0.82	GO:0030168	platelet activation
0.75	GO:0051258	protein polymerization
0.62	GO:0072378	blood coagulation, fibrin clot formation
0.59	GO:0034116	positive regulation of heterotypic cell-cell adhesion
0.59	GO:0007165	signal transduction
0.59	GO:0042730	fibrinolysis
0.58	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
0.58	GO:0045907	positive regulation of vasoconstriction
0.58	GO:2000352	negative regulation of endothelial cell apoptotic process
0.58	GO:0031639	plasminogen activation

0.78	GO:0030674	protein binding, bridging
0.71	GO:0005102	receptor binding
0.54	GO:0050839	cell adhesion molecule binding
0.45	GO:0005198	structural molecule activity
0.37	GO:0042803	protein homodimerization activity
0.36	GO:0046872	metal ion binding

0.85	GO:0005577	fibrinogen complex
0.58	GO:0031091	platelet alpha granule
0.55	GO:0009897	external side of plasma membrane
0.39	GO:0072562	blood microparticle
0.37	GO:0070062	extracellular exosome
0.36	GO:0034774	secretory granule lumen
0.36	GO:0005938	cell cortex
0.36	GO:0005788	endoplasmic reticulum lumen

sp|P02686|MBP_HUMAN
Myelin basic protein
Search

MBP

0.95	Myelin basic protein isoform B

0.50	GO:0042552	myelination
0.45	GO:0007605	sensory perception of sound
0.44	GO:1904207	regulation of chemokine (C-C motif) ligand 2 secretion
0.44	GO:0007417	central nervous system development
0.43	GO:0035633	maintenance of permeability of blood-brain barrier
0.43	GO:1904685	positive regulation of metalloendopeptidase activity
0.43	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production
0.43	GO:0034115	negative regulation of heterotypic cell-cell adhesion
0.42	GO:0090197	positive regulation of chemokine secretion
0.42	GO:2000778	positive regulation of interleukin-6 secretion

0.86	GO:0019911	structural constituent of myelin sheath
0.46	GO:0005516	calmodulin binding
0.46	GO:0002020	protease binding
0.34	GO:0005543	phospholipid binding

0.53	GO:0033269	internode region of axon
0.51	GO:0043209	myelin sheath
0.49	GO:0043025	neuronal cell body
0.40	GO:0043234	protein complex
0.40	GO:0071944	cell periphery
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|P02689|MYP2_HUMAN
Myelin P2 protein
Search

PMP2

0.97	Peripheral myelin protein 2

0.67

GO:0061024

membrane organization

0.72	GO:0008289	lipid binding
0.63	GO:0043178	alcohol binding
0.57	GO:0033293	monocarboxylic acid binding
0.39	GO:0097159	organic cyclic compound binding
0.34	GO:0005515	protein binding

0.81	GO:0043209	myelin sheath
0.38	GO:0070062	extracellular exosome
0.35	GO:0005737	cytoplasm

sp|P02708|ACHA_HUMAN
Acetylcholine receptor subunit alpha
Search

CHRNA1

0.93	Nicotinic acetylcholine recepter alpha-subunit

0.78	GO:0060079	excitatory postsynaptic potential
0.60	GO:0034220	ion transmembrane transport
0.48	GO:0007274	neuromuscular synaptic transmission
0.48	GO:0048630	skeletal muscle tissue growth
0.48	GO:0035094	response to nicotine
0.48	GO:0007271	synaptic transmission, cholinergic
0.47	GO:0070050	neuron cellular homeostasis
0.47	GO:0003009	skeletal muscle contraction
0.47	GO:0019228	neuronal action potential
0.46	GO:0046716	muscle cell cellular homeostasis

0.82	GO:0022848	acetylcholine-gated cation-selective channel activity
0.70	GO:0004888	transmembrane signaling receptor activity
0.50	GO:0042166	acetylcholine binding
0.36	GO:0005515	protein binding

0.78	GO:0045211	postsynaptic membrane
0.73	GO:0030054	cell junction
0.48	GO:0005892	acetylcholine-gated channel complex
0.46	GO:0031594	neuromuscular junction
0.43	GO:0009986	cell surface

sp|P02724|GLPA_HUMAN
Glycophorin-A
Search

GYPA

0.96	Glycophorin B MNS blood group

0.37	GO:0050900	leukocyte migration
0.35	GO:0030260	entry into host cell
0.35	GO:0047484	regulation of response to osmotic stress
0.35	GO:0007016	cytoskeletal anchoring at plasma membrane
0.35	GO:0019058	viral life cycle

0.39	GO:0005515	protein binding
0.38	GO:0104005	hijacked molecular function

0.37	GO:0070062	extracellular exosome
0.36	GO:0005886	plasma membrane
0.34	GO:0009986	cell surface
0.34	GO:0098552	side of membrane
0.30	GO:0031224	intrinsic component of membrane

sp|P02730|B3AT_HUMAN
Band 3 anion transport protein
Search

SLC4A1

0.64	Anion exchange protein (Fragment)

0.69	GO:0015698	inorganic anion transport
0.68	GO:0098656	anion transmembrane transport
0.60	GO:0015701	bicarbonate transport
0.48	GO:0051453	regulation of intracellular pH
0.47	GO:0098660	inorganic ion transmembrane transport
0.44	GO:0006814	sodium ion transport
0.40	GO:0098655	cation transmembrane transport
0.36	GO:0010037	response to carbon dioxide
0.36	GO:0010446	response to alkaline pH
0.36	GO:0014823	response to activity

0.82	GO:0005452	inorganic anion exchanger activity
0.60	GO:0015106	bicarbonate transmembrane transporter activity
0.59	GO:0030506	ankyrin binding
0.58	GO:0015301	anion:anion antiporter activity
0.54	GO:0015108	chloride transmembrane transporter activity
0.52	GO:0042803	protein homodimerization activity
0.45	GO:0015296	anion:cation symporter activity
0.44	GO:0015081	sodium ion transmembrane transporter activity
0.36	GO:0043495	protein membrane anchor
0.35	GO:0008022	protein C-terminus binding

0.57	GO:0016323	basolateral plasma membrane
0.56	GO:0030863	cortical cytoskeleton
0.50	GO:0005887	integral component of plasma membrane
0.44	GO:0030018	Z disc
0.38	GO:0072562	blood microparticle
0.37	GO:0070062	extracellular exosome
0.36	GO:0014704	intercalated disc
0.35	GO:0009986	cell surface
0.33	GO:0016324	apical plasma membrane

sp|P02741|CRP_HUMAN
C-reactive protein
Search

CRP

0.84

Pentaxin

0.59	GO:0010745	negative regulation of macrophage derived foam cell differentiation
0.58	GO:2000482	regulation of interleukin-8 secretion
0.58	GO:0032930	positive regulation of superoxide anion generation
0.58	GO:0010888	negative regulation of lipid storage
0.56	GO:0097756	negative regulation of blood vessel diameter
0.50	GO:0010628	positive regulation of gene expression
0.45	GO:0006953	acute-phase response
0.44	GO:0044870	modulation by host of viral glycoprotein metabolic process
0.44	GO:0052403	negative regulation by host of symbiont catalytic activity
0.44	GO:1903016	negative regulation of exo-alpha-sialidase activity

0.62	GO:0001849	complement component C1q binding
0.58	GO:0030169	low-density lipoprotein particle binding
0.57	GO:0050750	low-density lipoprotein particle receptor binding
0.53	GO:0046872	metal ion binding
0.52	GO:0042802	identical protein binding
0.45	GO:0046790	virion binding
0.36	GO:0033265	choline binding
0.35	GO:0030246	carbohydrate binding
0.35	GO:0015485	cholesterol binding
0.33	GO:0046983	protein dimerization activity

0.66	GO:0005576	extracellular region
0.36	GO:0031982	vesicle
0.35	GO:0030175	filopodium
0.35	GO:0030426	growth cone
0.30	GO:0044425	membrane part

sp|P02743|SAMP_HUMAN
Serum amyloid P-component
Search

0.83	Serum amyloid P-component

0.57	GO:0044870	modulation by host of viral glycoprotein metabolic process
0.57	GO:0052403	negative regulation by host of symbiont catalytic activity
0.57	GO:1903016	negative regulation of exo-alpha-sialidase activity
0.57	GO:0044867	modulation by host of viral catalytic activity
0.55	GO:0044793	negative regulation by host of viral process
0.55	GO:0045656	negative regulation of monocyte differentiation
0.55	GO:0046597	negative regulation of viral entry into host cell
0.55	GO:1903019	negative regulation of glycoprotein metabolic process
0.50	GO:0045087	innate immune response
0.41	GO:0006953	acute-phase response

0.57	GO:0001849	complement component C1q binding
0.56	GO:0046790	virion binding
0.53	GO:0046872	metal ion binding
0.49	GO:0042802	identical protein binding
0.38	GO:0030246	carbohydrate binding
0.38	GO:0030169	low-density lipoprotein particle binding
0.38	GO:0050750	low-density lipoprotein particle receptor binding
0.34	GO:0051082	unfolded protein binding
0.34	GO:0015485	cholesterol binding
0.34	GO:0016936	galactoside binding

0.66	GO:0005576	extracellular region
0.36	GO:0031982	vesicle
0.34	GO:0005634	nucleus
0.34	GO:0030175	filopodium
0.34	GO:0030426	growth cone
0.33	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

sp|P02745|C1QA_HUMAN
Complement C1q subcomponent subunit A
Search

C1QA

0.97	Complement component 1, q subcomponent, A chain

0.80	GO:0006958	complement activation, classical pathway
0.42	GO:0010039	response to iron ion
0.41	GO:0045087	innate immune response
0.37	GO:0030449	regulation of complement activation
0.36	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
0.35	GO:0007267	cell-cell signaling
0.35	GO:0030198	extracellular matrix organization
0.35	GO:0048646	anatomical structure formation involved in morphogenesis
0.35	GO:0061304	retinal blood vessel morphogenesis
0.35	GO:0071230	cellular response to amino acid stimulus

0.42	GO:0005201	extracellular matrix structural constituent
0.36	GO:0005515	protein binding
0.35	GO:0004252	serine-type endopeptidase activity
0.35	GO:0030414	peptidase inhibitor activity
0.34	GO:0061135	endopeptidase regulator activity
0.32	GO:0030246	carbohydrate binding
0.32	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds

0.75	GO:0005581	collagen trimer
0.63	GO:0005576	extracellular region
0.37	GO:0031982	vesicle
0.34	GO:0099081	supramolecular polymer
0.34	GO:0030056	hemidesmosome
0.33	GO:0042383	sarcolemma
0.33	GO:0005788	endoplasmic reticulum lumen
0.32	GO:0019867	outer membrane
0.30	GO:0016021	integral component of membrane

0.35

GO:0004252

sp|P02746|C1QB_HUMAN
Complement C1q subcomponent subunit B
Search

C1QB

0.96	Complement 1 subcomponent q polypeptide beta (Fragment)

0.70	GO:0006958	complement activation, classical pathway
0.53	GO:0048839	inner ear development
0.49	GO:0045650	negative regulation of macrophage differentiation
0.49	GO:0030853	negative regulation of granulocyte differentiation
0.40	GO:0045087	innate immune response
0.37	GO:0030449	regulation of complement activation
0.35	GO:0051384	response to glucocorticoid
0.35	GO:0006898	receptor-mediated endocytosis
0.35	GO:0007420	brain development
0.35	GO:0007568	aging

0.50	GO:0042803	protein homodimerization activity
0.41	GO:0005201	extracellular matrix structural constituent
0.37	GO:0042302	structural constituent of cuticle
0.36	GO:0005044	scavenger receptor activity
0.35	GO:0004252	serine-type endopeptidase activity
0.33	GO:0030246	carbohydrate binding
0.33	GO:0004867	serine-type endopeptidase inhibitor activity
0.33	GO:0048407	platelet-derived growth factor binding
0.33	GO:0005178	integrin binding
0.32	GO:0005164	tumor necrosis factor receptor binding

0.74	GO:0005581	collagen trimer
0.60	GO:0005576	extracellular region
0.37	GO:0031982	vesicle
0.33	GO:0099081	supramolecular polymer
0.32	GO:0005783	endoplasmic reticulum
0.32	GO:0005829	cytosol
0.32	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.35

GO:0004252

sp|P02747|C1QC_HUMAN
Complement C1q subcomponent subunit C
Search

C1QC

0.92	Complement component 1, q subcomponent, C chain

0.64	GO:0045650	negative regulation of macrophage differentiation
0.64	GO:0030853	negative regulation of granulocyte differentiation
0.55	GO:0006958	complement activation, classical pathway
0.43	GO:0007423	sensory organ development
0.42	GO:0045087	innate immune response
0.38	GO:0030449	regulation of complement activation
0.38	GO:0035987	endodermal cell differentiation
0.37	GO:0050673	epithelial cell proliferation
0.37	GO:0010811	positive regulation of cell-substrate adhesion
0.36	GO:0009887	animal organ morphogenesis

0.47	GO:0005201	extracellular matrix structural constituent
0.41	GO:0042803	protein homodimerization activity
0.35	GO:0004252	serine-type endopeptidase activity
0.34	GO:0004867	serine-type endopeptidase inhibitor activity
0.34	GO:0042302	structural constituent of cuticle

0.77	GO:0005581	collagen trimer
0.65	GO:0005576	extracellular region
0.38	GO:0031982	vesicle
0.34	GO:0031594	neuromuscular junction
0.34	GO:0099080	supramolecular complex
0.34	GO:0005938	cell cortex
0.30	GO:0016020	membrane

0.35

GO:0004252

sp|P02748|CO9_HUMAN
Complement component C9
Search

0.97	Complement component 9

0.72	GO:0006955	immune response
0.61	GO:0001906	cell killing
0.61	GO:0051260	protein homooligomerization
0.48	GO:0072376	protein activation cascade
0.47	GO:0002253	activation of immune response
0.46	GO:0002252	immune effector process
0.44	GO:0019835	cytolysis
0.43	GO:0006952	defense response
0.43	GO:0071391	cellular response to estrogen stimulus
0.38	GO:0030449	regulation of complement activation

0.84	GO:0005579	membrane attack complex
0.57	GO:0005615	extracellular space
0.53	GO:0005829	cytosol
0.41	GO:0044218	other organism cell membrane
0.39	GO:1903561	extracellular vesicle

sp|P02749|APOH_HUMAN
Beta-2-glycoprotein 1
Search

APOH

0.93	Beta-2-glycoprotein 1

0.86	GO:0007597	blood coagulation, intrinsic pathway
0.86	GO:0034392	negative regulation of smooth muscle cell apoptotic process
0.86	GO:0051918	negative regulation of fibrinolysis
0.86	GO:0051006	positive regulation of lipoprotein lipase activity
0.85	GO:0033033	negative regulation of myeloid cell apoptotic process
0.85	GO:0031639	plasminogen activation
0.84	GO:0001937	negative regulation of endothelial cell proliferation
0.84	GO:0010596	negative regulation of endothelial cell migration
0.84	GO:0030195	negative regulation of blood coagulation
0.81	GO:0016525	negative regulation of angiogenesis

0.86	GO:0060230	lipoprotein lipase activator activity
0.73	GO:0008201	heparin binding
0.73	GO:0005543	phospholipid binding
0.71	GO:0042802	identical protein binding

0.85	GO:0042627	chylomicron
0.84	GO:0034361	very-low-density lipoprotein particle
0.84	GO:0034364	high-density lipoprotein particle
0.73	GO:0009986	cell surface
0.72	GO:0031012	extracellular matrix
0.54	GO:0031089	platelet dense granule lumen
0.54	GO:0070062	extracellular exosome
0.38	GO:0005886	plasma membrane

sp|P02750|A2GL_HUMAN
Leucine-rich alpha-2-glycoprotein
Search

LRG1

0.97	Leucine rich alpha-2-glycoprotein 1

0.76	GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus
0.75	GO:0050873	brown fat cell differentiation
0.74	GO:0001938	positive regulation of endothelial cell proliferation
0.73	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
0.73	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
0.73	GO:0045766	positive regulation of angiogenesis
0.54	GO:0045087	innate immune response
0.47	GO:0007409	axonogenesis
0.47	GO:0007165	signal transduction
0.46	GO:0002252	immune effector process

0.75	GO:0005160	transforming growth factor beta receptor binding
0.48	GO:0046790	virion binding
0.47	GO:0005030	neurotrophin receptor activity
0.36	GO:0070052	collagen V binding
0.35	GO:0008201	heparin binding
0.35	GO:0004672	protein kinase activity
0.34	GO:0038187	pattern recognition receptor activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.65	GO:0005615	extracellular space
0.50	GO:0043231	intracellular membrane-bounded organelle
0.45	GO:0009897	external side of plasma membrane
0.43	GO:1904724	tertiary granule lumen
0.43	GO:0035580	specific granule lumen
0.43	GO:1903561	extracellular vesicle
0.42	GO:1904813	ficolin-1-rich granule lumen
0.39	GO:0005578	proteinaceous extracellular matrix
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:3.1.3.16

GO:0004721

sp|P02751|FINC_HUMAN
Fibronectin
Search

FN1

0.45	Fibronectin

0.64	GO:1904237	positive regulation of substrate-dependent cell migration, cell attachment to substrate
0.64	GO:2001202	negative regulation of transforming growth factor-beta secretion
0.63	GO:0007161	calcium-independent cell-matrix adhesion
0.62	GO:0052047	interaction with other organism via secreted substance involved in symbiotic interaction
0.62	GO:0033622	integrin activation
0.59	GO:0045773	positive regulation of axon extension
0.59	GO:0048146	positive regulation of fibroblast proliferation
0.59	GO:0035987	endodermal cell differentiation
0.59	GO:0007044	cell-substrate junction assembly
0.59	GO:0034446	substrate adhesion-dependent cell spreading

0.60	GO:0097718	disordered domain specific binding
0.58	GO:0005178	integrin binding
0.58	GO:0002020	protease binding
0.58	GO:0016504	peptidase activator activity
0.57	GO:0008022	protein C-terminus binding
0.54	GO:0051087	chaperone binding
0.53	GO:0042802	identical protein binding
0.41	GO:0008201	heparin binding
0.33	GO:0005518	collagen binding
0.32	GO:0045340	mercury ion binding

0.66	GO:0005576	extracellular region
0.58	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.56	GO:0016324	apical plasma membrane
0.52	GO:0031982	vesicle
0.45	GO:0043234	protein complex
0.33	GO:0005788	endoplasmic reticulum lumen
0.33	GO:0045178	basal part of cell
0.33	GO:0048471	perinuclear region of cytoplasm
0.32	GO:0009986	cell surface
0.32	GO:0099512	supramolecular fiber

sp|P02753|RET4_HUMAN
Retinol-binding protein 4
Search

RBP4

0.97	Plasma retinol binding protein 4

0.86	GO:0034633	retinol transport
0.55	GO:0032526	response to retinoic acid
0.55	GO:0030277	maintenance of gastrointestinal epithelium
0.54	GO:0042572	retinol metabolic process
0.54	GO:0032024	positive regulation of insulin secretion
0.52	GO:0001654	eye development
0.51	GO:0042593	glucose homeostasis
0.48	GO:0019319	hexose biosynthetic process
0.47	GO:0006006	glucose metabolic process
0.40	GO:0001889	liver development

0.86	GO:0034632	retinol transmembrane transporter activity
0.83	GO:0005501	retinoid binding
0.54	GO:0043178	alcohol binding
0.46	GO:0019842	vitamin binding
0.36	GO:0046982	protein heterodimerization activity
0.34	GO:0019904	protein domain specific binding
0.33	GO:0005102	receptor binding

0.50	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.36	GO:0060418	yolk plasma
0.34	GO:0043234	protein complex
0.34	GO:0030136	clathrin-coated vesicle
0.34	GO:0033165	interphotoreceptor matrix
0.33	GO:0005829	cytosol

sp|P02760|AMBP_HUMAN
Protein AMBP
Search

AMBP

0.97	Alpha-1-microglobulin/bikunin precursor

0.76	GO:0010951	negative regulation of endopeptidase activity
0.42	GO:0018298	protein-chromophore linkage
0.37	GO:0030163	protein catabolic process
0.37	GO:0042167	heme catabolic process
0.37	GO:0046329	negative regulation of JNK cascade
0.36	GO:0007565	female pregnancy
0.35	GO:0050777	negative regulation of immune response
0.35	GO:0007155	cell adhesion
0.35	GO:0006898	receptor-mediated endocytosis
0.35	GO:0007018	microtubule-based movement

0.78	GO:0004867	serine-type endopeptidase inhibitor activity
0.66	GO:0019862	IgA binding
0.55	GO:0042803	protein homodimerization activity
0.49	GO:0020037	heme binding
0.38	GO:0046904	calcium oxalate binding
0.37	GO:0019855	calcium channel inhibitor activity
0.35	GO:0003777	microtubule motor activity
0.35	GO:0008017	microtubule binding
0.33	GO:0008144	drug binding
0.33	GO:0097367	carbohydrate derivative binding

0.53	GO:0031012	extracellular matrix
0.45	GO:0005886	plasma membrane
0.39	GO:0072562	blood microparticle
0.38	GO:0009986	cell surface
0.38	GO:0070062	extracellular exosome
0.35	GO:0043231	intracellular membrane-bounded organelle
0.34	GO:0005874	microtubule
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0008233

sp|P02763|A1AG1_HUMAN
Alpha-1-acid glycoprotein 1
Search

0.97	Alpha-1-acid glycoprotein 1

0.71	GO:0002682	regulation of immune system process
0.57	GO:1904469	positive regulation of tumor necrosis factor secretion
0.56	GO:0050718	positive regulation of interleukin-1 beta secretion
0.52	GO:0032715	negative regulation of interleukin-6 production
0.52	GO:0032720	negative regulation of tumor necrosis factor production
0.51	GO:0006953	acute-phase response
0.43	GO:0002576	platelet degranulation
0.43	GO:0043312	neutrophil degranulation
0.37	GO:0002439	chronic inflammatory response to antigenic stimulus
0.37	GO:0033197	response to vitamin E

0.35	GO:0005515	protein binding
0.33	GO:0008144	drug binding

0.73	GO:0005615	extracellular space
0.49	GO:0031012	extracellular matrix
0.44	GO:0035580	specific granule lumen
0.44	GO:0031093	platelet alpha granule lumen
0.42	GO:1903561	extracellular vesicle
0.40	GO:1904724	tertiary granule lumen
0.40	GO:0035578	azurophil granule lumen
0.35	GO:0005581	collagen trimer
0.30	GO:0031224	intrinsic component of membrane

sp|P02765|FETUA_HUMAN
Alpha-2-HS-glycoprotein
Search

AHSG

0.97

Fetuin-A

0.76	GO:0010951	negative regulation of endopeptidase activity
0.67	GO:0070168	negative regulation of biomineral tissue development
0.64	GO:0006953	acute-phase response
0.64	GO:0050766	positive regulation of phagocytosis
0.64	GO:0030279	negative regulation of ossification
0.63	GO:0030500	regulation of bone mineralization
0.61	GO:0050727	regulation of inflammatory response
0.60	GO:0001503	ossification
0.39	GO:0046627	negative regulation of insulin receptor signaling pathway
0.38	GO:0048731	system development

0.83	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.38	GO:0019210	kinase inhibitor activity
0.38	GO:0008191	metalloendopeptidase inhibitor activity
0.35	GO:0005515	protein binding
0.35	GO:0019887	protein kinase regulator activity

0.70	GO:0005615	extracellular space
0.57	GO:0031012	extracellular matrix
0.54	GO:0005794	Golgi apparatus
0.41	GO:0043230	extracellular organelle
0.39	GO:0031982	vesicle
0.37	GO:0005788	endoplasmic reticulum lumen
0.34	GO:0005886	plasma membrane
0.33	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

sp|P02766|TTHY_HUMAN
Transthyretin
Search

TTR

0.95	Transthyretin

0.85	GO:0070327	thyroid hormone transport
0.85	GO:0042572	retinol metabolic process
0.47	GO:0010469	regulation of receptor activity
0.45	GO:0006144	purine nucleobase metabolic process
0.38	GO:0051262	protein tetramerization
0.37	GO:0051260	protein homooligomerization
0.36	GO:0043312	neutrophil degranulation
0.35	GO:0042403	thyroid hormone metabolic process
0.35	GO:0001555	oocyte growth
0.35	GO:0030198	extracellular matrix organization

0.86	GO:0070324	thyroid hormone binding
0.49	GO:0042802	identical protein binding
0.49	GO:0005179	hormone activity
0.39	GO:0046982	protein heterodimerization activity
0.38	GO:0033971	hydroxyisourate hydrolase activity
0.34	GO:0019904	protein domain specific binding
0.33	GO:0005509	calcium ion binding
0.33	GO:0036094	small molecule binding

0.65	GO:0005576	extracellular region
0.36	GO:0031982	vesicle
0.36	GO:0043234	protein complex
0.36	GO:0005766	primary lysosome
0.35	GO:0005775	vacuolar lumen
0.35	GO:0060417	yolk
0.34	GO:0012505	endomembrane system
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.38	EC:3.5.2.17	GO:0033971
0.38	KEGG:R06601	GO:0033971

sp|P02768|ALBU_HUMAN
Serum albumin
Search

ALB

0.94	serum albumin precursor

0.62	GO:0051659	maintenance of mitochondrion location
0.58	GO:0019836	hemolysis by symbiont of host erythrocytes
0.54	GO:0009267	cellular response to starvation
0.54	GO:0043066	negative regulation of apoptotic process
0.44	GO:0001542	ovulation from ovarian follicle
0.44	GO:0042448	progesterone metabolic process
0.43	GO:0060395	SMAD protein signal transduction
0.40	GO:0071693	protein transport within extracellular region
0.38	GO:0050821	protein stabilization
0.38	GO:0001895	retina homeostasis

0.58	GO:0005504	fatty acid binding
0.56	GO:0015643	toxic substance binding
0.54	GO:0019825	oxygen binding
0.49	GO:0051087	chaperone binding
0.48	GO:0030170	pyridoxal phosphate binding
0.48	GO:0042802	identical protein binding
0.42	GO:0003677	DNA binding
0.40	GO:0008431	vitamin E binding
0.39	GO:0046872	metal ion binding
0.35	GO:0004817	cysteine-tRNA ligase activity

0.73	GO:0005615	extracellular space
0.52	GO:0043209	myelin sheath
0.51	GO:1903561	extracellular vesicle
0.49	GO:0005794	Golgi apparatus
0.48	GO:0005783	endoplasmic reticulum
0.45	GO:0043234	protein complex
0.37	GO:0031093	platelet alpha granule lumen
0.35	GO:0060417	yolk
0.35	GO:0005604	basement membrane
0.34	GO:0005634	nucleus

0.35

EC:6.1.1.16

GO:0004817

sp|P02771|FETA_HUMAN
Alpha-fetoprotein
Search

ALB

0.76	Serum albumin

0.62	GO:0001542	ovulation from ovarian follicle
0.62	GO:0042448	progesterone metabolic process
0.60	GO:0060395	SMAD protein signal transduction
0.46	GO:0051659	maintenance of mitochondrion location
0.44	GO:0019836	hemolysis by symbiont of host erythrocytes
0.42	GO:0009267	cellular response to starvation
0.42	GO:0043066	negative regulation of apoptotic process
0.37	GO:0043687	post-translational protein modification
0.36	GO:0031100	animal organ regeneration
0.35	GO:0031016	pancreas development

0.44	GO:0005504	fatty acid binding
0.43	GO:0015643	toxic substance binding
0.42	GO:0019825	oxygen binding
0.39	GO:0051087	chaperone binding
0.39	GO:0030170	pyridoxal phosphate binding
0.39	GO:0042802	identical protein binding
0.39	GO:0046872	metal ion binding
0.36	GO:0003677	DNA binding
0.33	GO:0016209	antioxidant activity

0.73	GO:0005615	extracellular space
0.41	GO:0005737	cytoplasm
0.41	GO:0043209	myelin sheath
0.40	GO:1903561	extracellular vesicle
0.40	GO:0012505	endomembrane system
0.37	GO:0043234	protein complex
0.37	GO:0043231	intracellular membrane-bounded organelle
0.35	GO:0043233	organelle lumen
0.34	GO:0044446	intracellular organelle part
0.33	GO:0097708	intracellular vesicle

sp|P02774|VTDB_HUMAN
Vitamin D-binding protein
Search

0.97	vitamin D-binding protein isoform X1

0.81	GO:0035461	vitamin transmembrane transport
0.64	GO:0042359	vitamin D metabolic process
0.37	GO:0007595	lactation
0.37	GO:0032355	response to estradiol
0.37	GO:0007565	female pregnancy
0.36	GO:0048545	response to steroid hormone
0.36	GO:0031667	response to nutrient levels

0.87	GO:0005499	vitamin D binding
0.76	GO:0090482	vitamin transmembrane transporter activity
0.56	GO:0003779	actin binding
0.44	GO:0008144	drug binding

0.73	GO:0005615	extracellular space
0.39	GO:1903561	extracellular vesicle
0.38	GO:0043202	lysosomal lumen
0.37	GO:0005829	cytosol
0.36	GO:0030424	axon
0.36	GO:0048471	perinuclear region of cytoplasm

sp|P02775|CXCL7_HUMAN
Platelet basic protein
Search

PPBP

0.75	C-X-C motif chemokine

0.82	GO:0060326	cell chemotaxis
0.74	GO:0006955	immune response
0.72	GO:0010469	regulation of receptor activity
0.71	GO:0006952	defense response
0.58	GO:0050900	leukocyte migration
0.57	GO:0042119	neutrophil activation
0.51	GO:0090023	positive regulation of neutrophil chemotaxis
0.49	GO:0070098	chemokine-mediated signaling pathway
0.49	GO:0032496	response to lipopolysaccharide
0.47	GO:0042127	regulation of cell proliferation

0.84	GO:0008009	chemokine activity
0.64	GO:0045236	CXCR chemokine receptor binding
0.42	GO:0008201	heparin binding
0.38	GO:0008083	growth factor activity
0.37	GO:0005355	glucose transmembrane transporter activity
0.34	GO:0008047	enzyme activator activity

0.70	GO:0005615	extracellular space
0.39	GO:1904724	tertiary granule lumen
0.39	GO:0034774	secretory granule lumen
0.37	GO:0031091	platelet alpha granule
0.35	GO:0042581	specific granule
0.30	GO:0016020	membrane

sp|P02776|PLF4_HUMAN
Platelet factor 4
Search

0.80	C-X-C motif chemokine

0.82	GO:0060326	cell chemotaxis
0.81	GO:0030168	platelet activation
0.80	GO:0050900	leukocyte migration
0.75	GO:0010469	regulation of receptor activity
0.74	GO:0006955	immune response
0.72	GO:0006952	defense response
0.59	GO:0001562	response to protozoan
0.54	GO:0019221	cytokine-mediated signaling pathway
0.53	GO:0045347	negative regulation of MHC class II biosynthetic process
0.53	GO:0045653	negative regulation of megakaryocyte differentiation

0.84	GO:0008009	chemokine activity
0.79	GO:0008201	heparin binding
0.58	GO:0045236	CXCR chemokine receptor binding

0.73	GO:0005615	extracellular space
0.54	GO:0097679	other organism cytoplasm
0.53	GO:0020005	symbiont-containing vacuole membrane
0.37	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|P02778|CXL10_HUMAN
C-X-C motif chemokine 10
Search

CXCL10

0.83	C-X-C motif chemokine

0.82	GO:0060326	cell chemotaxis
0.75	GO:1901740	negative regulation of myoblast fusion
0.74	GO:0010469	regulation of receptor activity
0.74	GO:0006955	immune response
0.73	GO:1901509	regulation of endothelial tube morphogenesis
0.73	GO:0043950	positive regulation of cAMP-mediated signaling
0.72	GO:0072678	T cell migration
0.72	GO:0006952	defense response
0.72	GO:0010819	regulation of T cell chemotaxis
0.72	GO:0042118	endothelial cell activation

0.84	GO:0008009	chemokine activity
0.75	GO:0048248	CXCR3 chemokine receptor binding
0.66	GO:0008201	heparin binding
0.38	GO:0008603	cAMP-dependent protein kinase regulator activity

0.73	GO:0005615	extracellular space
0.66	GO:0009897	external side of plasma membrane

sp|P02786|TFR1_HUMAN
Transferrin receptor protein 1
Search

TFRC

0.93	Transferrin receptor

0.85	GO:0033572	transferrin transport
0.73	GO:0006879	cellular iron ion homeostasis
0.69	GO:0006898	receptor-mediated endocytosis
0.60	GO:0045830	positive regulation of isotype switching
0.59	GO:0030890	positive regulation of B cell proliferation
0.58	GO:0042102	positive regulation of T cell proliferation
0.58	GO:0097286	iron ion import
0.57	GO:0045780	positive regulation of bone resorption
0.56	GO:0030316	osteoclast differentiation
0.55	GO:0043112	receptor metabolic process

0.85	GO:0033570	transferrin transmembrane transporter activity
0.85	GO:0004998	transferrin receptor activity
0.52	GO:0003725	double-stranded RNA binding
0.51	GO:0042803	protein homodimerization activity
0.36	GO:0001618	virus receptor activity
0.35	GO:0030544	Hsp70 protein binding
0.34	GO:0051087	chaperone binding
0.34	GO:0039706	co-receptor binding

0.58	GO:1990712	HFE-transferrin receptor complex
0.55	GO:0055037	recycling endosome
0.55	GO:0016323	basolateral plasma membrane
0.54	GO:0009897	external side of plasma membrane
0.54	GO:0005905	clathrin-coated pit
0.53	GO:0070062	extracellular exosome
0.53	GO:0048471	perinuclear region of cytoplasm
0.53	GO:0005769	early endosome
0.53	GO:0010008	endosome membrane
0.47	GO:0005887	integral component of plasma membrane

sp|P02787|TRFE_HUMAN
Serotransferrin
Search

LTF

0.65	Inhibitor of carbonic anhydrase

0.76	GO:0019732	antifungal humoral response
0.74	GO:0019731	antibacterial humoral response
0.68	GO:0001817	regulation of cytokine production
0.61	GO:1900229	negative regulation of single-species biofilm formation in or on host organism
0.60	GO:1902732	positive regulation of chondrocyte proliferation
0.59	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
0.59	GO:0002227	innate immune response in mucosa
0.59	GO:0033690	positive regulation of osteoblast proliferation
0.58	GO:0044793	negative regulation by host of viral process
0.58	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway

0.60	GO:0004252	serine-type endopeptidase activity
0.58	GO:0004857	enzyme inhibitor activity
0.55	GO:0005506	iron ion binding
0.55	GO:0043539	protein serine/threonine kinase activator activity
0.54	GO:0008201	heparin binding
0.54	GO:0001530	lipopolysaccharide binding
0.51	GO:0061135	endopeptidase regulator activity
0.36	GO:0005525	GTP binding
0.35	GO:0005515	protein binding
0.34	GO:0003677	DNA binding

0.71	GO:0005615	extracellular space
0.58	GO:0042581	specific granule
0.51	GO:0009986	cell surface
0.47	GO:0044218	other organism cell membrane
0.44	GO:0043234	protein complex
0.40	GO:0097013	phagocytic vesicle lumen
0.40	GO:1904724	tertiary granule lumen
0.39	GO:0034774	secretory granule lumen
0.38	GO:1903561	extracellular vesicle
0.37	GO:0005634	nucleus

0.60

GO:0004252

sp|P02788|TRFL_HUMAN
Lactotransferrin
Search

LTF

0.70	Truncated lactoferrin

0.85	GO:0019732	antifungal humoral response
0.82	GO:0019731	antibacterial humoral response
0.75	GO:0001817	regulation of cytokine production
0.63	GO:1900229	negative regulation of single-species biofilm formation in or on host organism
0.62	GO:1902732	positive regulation of chondrocyte proliferation
0.61	GO:0044793	negative regulation by host of viral process
0.61	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
0.61	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
0.61	GO:0002227	innate immune response in mucosa
0.60	GO:0033690	positive regulation of osteoblast proliferation

0.66	GO:0004252	serine-type endopeptidase activity
0.62	GO:0005506	iron ion binding
0.58	GO:0043539	protein serine/threonine kinase activator activity
0.56	GO:0008201	heparin binding
0.56	GO:0001530	lipopolysaccharide binding
0.56	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.46	GO:0015091	ferric iron transmembrane transporter activity
0.42	GO:1990459	transferrin receptor binding
0.34	GO:0005525	GTP binding
0.34	GO:0003677	DNA binding

0.71	GO:0005615	extracellular space
0.59	GO:0042581	specific granule
0.55	GO:0009986	cell surface
0.49	GO:0044218	other organism cell membrane
0.45	GO:0043234	protein complex
0.43	GO:0030139	endocytic vesicle
0.42	GO:1990712	HFE-transferrin receptor complex
0.42	GO:0009925	basal plasma membrane
0.41	GO:0055037	recycling endosome
0.40	GO:0016324	apical plasma membrane

0.66

GO:0004252

sp|P02790|HEMO_HUMAN
Hemopexin
Search

HPX

0.92

Hemopexin

0.75	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin
0.75	GO:0060332	positive regulation of response to interferon-gamma
0.73	GO:0020027	hemoglobin metabolic process
0.73	GO:0060334	regulation of interferon-gamma-mediated signaling pathway
0.72	GO:0001961	positive regulation of cytokine-mediated signaling pathway
0.72	GO:0002639	positive regulation of immunoglobulin production
0.71	GO:0015886	heme transport
0.71	GO:0006879	cellular iron ion homeostasis
0.71	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
0.60	GO:0042168	heme metabolic process

0.72	GO:0015232	heme transporter activity
0.53	GO:0046872	metal ion binding
0.38	GO:0004415	hyalurononglucosaminidase activity
0.36	GO:0020037	heme binding
0.36	GO:0004222	metalloendopeptidase activity
0.35	GO:0005515	protein binding

0.61	GO:0005615	extracellular space
0.40	GO:1903561	extracellular vesicle
0.40	GO:0071682	endocytic vesicle lumen
0.36	GO:0031012	extracellular matrix
0.30	GO:0016020	membrane

0.38

EC:3.2.1.35

GO:0004415

sp|P02792|FRIL_HUMAN
Ferritin light chain
Search

FTL

0.55	Ferritin light chain

0.76	GO:0006879	cellular iron ion homeostasis
0.75	GO:0006826	iron ion transport
0.56	GO:0051238	sequestering of metal ion
0.52	GO:0051651	maintenance of location in cell
0.36	GO:0043312	neutrophil degranulation
0.35	GO:0010288	response to lead ion
0.33	GO:0055114	oxidation-reduction process

0.75	GO:0008199	ferric iron binding
0.39	GO:0042802	identical protein binding
0.36	GO:0004322	ferroxidase activity

0.49	GO:0070288	ferritin complex
0.42	GO:0044754	autolysosome
0.37	GO:0060205	cytoplasmic vesicle lumen
0.36	GO:0070062	extracellular exosome
0.36	GO:0005766	primary lysosome
0.35	GO:0005775	vacuolar lumen
0.35	GO:0030141	secretory granule
0.34	GO:0030139	endocytic vesicle
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.36

EC:1.16.3.1

GO:0004322

sp|P02794|FRIH_HUMAN
Ferritin heavy chain
Search

FTH1

0.54	Ferritin heavy chain

0.76	GO:0006879	cellular iron ion homeostasis
0.75	GO:0006826	iron ion transport
0.50	GO:0051238	sequestering of metal ion
0.47	GO:0051651	maintenance of location in cell
0.44	GO:0008285	negative regulation of cell proliferation
0.42	GO:0006955	immune response
0.40	GO:0048145	regulation of fibroblast proliferation
0.38	GO:0055114	oxidation-reduction process
0.35	GO:0060547	negative regulation of necrotic cell death
0.35	GO:0002446	neutrophil mediated immunity

0.76	GO:0008199	ferric iron binding
0.46	GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor
0.35	GO:0005515	protein binding
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0003723	RNA binding

0.40	GO:0044754	autolysosome
0.36	GO:0005739	mitochondrion
0.36	GO:0070062	extracellular exosome
0.35	GO:0070288	ferritin complex
0.35	GO:1904724	tertiary granule lumen
0.35	GO:0071682	endocytic vesicle lumen
0.35	GO:1904813	ficolin-1-rich granule lumen
0.34	GO:0005634	nucleus
0.33	GO:0005829	cytosol
0.32	GO:0005840	ribosome

0.46

EC:1.16.3

GO:0016724

sp|P02795|MT2_HUMAN
Metallothionein-2
Search

0.75	Metallothionein-I, hippocampal

0.65	GO:0071294	cellular response to zinc ion
0.56	GO:0045926	negative regulation of growth
0.49	GO:0036018	cellular response to erythropoietin
0.48	GO:0071276	cellular response to cadmium ion
0.45	GO:0036015	response to interleukin-3
0.41	GO:0035690	cellular response to drug
0.40	GO:0046688	response to copper ion
0.39	GO:0007263	nitric oxide mediated signal transduction
0.39	GO:0097501	stress response to metal ion
0.38	GO:0006882	cellular zinc ion homeostasis

0.54	GO:0046872	metal ion binding
0.36	GO:0005515	protein binding
0.36	GO:0008144	drug binding

0.55	GO:0048471	perinuclear region of cytoplasm
0.47	GO:0005634	nucleus
0.35	GO:0005829	cytosol

sp|P02808|STAT_HUMAN
Statherin
Search

STATH

0.97

Statherin

0.85	GO:0030500	regulation of bone mineralization
0.78	GO:0042742	defense response to bacterium
0.57	GO:0031214	biomineral tissue development
0.51	GO:0046541	saliva secretion
0.51	GO:0070168	negative regulation of biomineral tissue development
0.49	GO:0030279	negative regulation of ossification
0.48	GO:0001503	ossification

0.88	GO:0046848	hydroxyapatite binding
0.54	GO:0030197	extracellular matrix constituent, lubricant activity
0.52	GO:0030345	structural constituent of tooth enamel
0.42	GO:0005515	protein binding

0.66

GO:0005576

extracellular region

sp|P02810|PRPC_HUMAN
Salivary acidic proline-rich phosphoprotein 1/2
Search

0.63	Proline-rich proteoglycan

0.42	GO:0051301	cell division
0.41	GO:0007049	cell cycle
0.39	GO:0006325	chromatin organization
0.38	GO:0036211	protein modification process
0.38	GO:0044267	cellular protein metabolic process
0.38	GO:0050829	defense response to Gram-negative bacterium
0.37	GO:0009793	embryo development ending in seed dormancy
0.37	GO:0006886	intracellular protein transport
0.37	GO:0006888	ER to Golgi vesicle-mediated transport
0.37	GO:0031047	gene silencing by RNA

0.40	GO:0005515	protein binding
0.39	GO:0004674	protein serine/threonine kinase activity
0.39	GO:0052861	glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group
0.38	GO:0008270	zinc ion binding
0.38	GO:0017076	purine nucleotide binding
0.38	GO:0097367	carbohydrate derivative binding
0.38	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0003713	transcription coactivator activity
0.37	GO:0003676	nucleic acid binding
0.37	GO:0008144	drug binding

0.44	GO:0005576	extracellular region
0.41	GO:0005634	nucleus
0.39	GO:0070013	intracellular organelle lumen
0.38	GO:0031248	protein acetyltransferase complex
0.38	GO:0044446	intracellular organelle part
0.37	GO:0005737	cytoplasm
0.37	GO:0012506	vesicle membrane
0.37	GO:0048475	coated membrane
0.36	GO:0097708	intracellular vesicle
0.36	GO:0098805	whole membrane

0.39

GO:0004674

sp|P02812|PRB2_HUMAN
Basic salivary proline-rich protein 2
Search

0.66	Basic salivary proline-rich protein 2

0.43	GO:0050829	defense response to Gram-negative bacterium
0.39	GO:2001141	regulation of RNA biosynthetic process
0.39	GO:0010469	regulation of receptor activity
0.36	GO:0015671	oxygen transport
0.36	GO:0000128	flocculation
0.35	GO:0009405	pathogenesis
0.35	GO:0006508	proteolysis
0.34	GO:0018298	protein-chromophore linkage
0.34	GO:0007186	G-protein coupled receptor signaling pathway
0.34	GO:0030163	protein catabolic process

0.46	GO:0003713	transcription coactivator activity
0.41	GO:0052861	glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group
0.41	GO:0005544	calcium-dependent phospholipid binding
0.40	GO:0005515	protein binding
0.39	GO:0030545	receptor regulator activity
0.38	GO:0005509	calcium ion binding
0.36	GO:0005344	oxygen carrier activity
0.36	GO:0004222	metalloendopeptidase activity
0.35	GO:0008270	zinc ion binding
0.34	GO:0009881	photoreceptor activity

0.55	GO:0005576	extracellular region
0.34	GO:0005634	nucleus
0.34	GO:0005887	integral component of plasma membrane
0.33	GO:0005694	chromosome

0.41

EC:3.2.1.6

GO:0052861

sp|P02814|SMR3B_HUMAN
Submaxillary gland androgen-regulated protein 3B
Search

0.44	GO:0051930	regulation of sensory perception of pain
0.43	GO:0006468	protein phosphorylation
0.42	GO:0060255	regulation of macromolecule metabolic process
0.42	GO:0080090	regulation of primary metabolic process
0.42	GO:0031323	regulation of cellular metabolic process
0.42	GO:0051171	regulation of nitrogen compound metabolic process
0.41	GO:0065009	regulation of molecular function
0.41	GO:0009889	regulation of biosynthetic process
0.39	GO:0035023	regulation of Rho protein signal transduction
0.39	GO:0048523	negative regulation of cellular process

0.45	GO:0005515	protein binding
0.43	GO:0004672	protein kinase activity
0.42	GO:0098772	molecular function regulator
0.41	GO:0032559	adenyl ribonucleotide binding
0.40	GO:0008144	drug binding
0.40	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0003777	microtubule motor activity
0.39	GO:0004175	endopeptidase activity
0.37	GO:0070001	aspartic-type peptidase activity
0.37	GO:0008236	serine-type peptidase activity

0.50	GO:0005576	extracellular region
0.45	GO:0031982	vesicle
0.39	GO:0016459	myosin complex
0.36	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.36

GO:0016491

sp|P02818|OSTCN_HUMAN
Osteocalcin
Search

BGLAP

0.97	Osteocalcin

0.85	GO:0030500	regulation of bone mineralization
0.66	GO:0033280	response to vitamin D
0.64	GO:0001649	osteoblast differentiation
0.62	GO:0031214	biomineral tissue development
0.42	GO:0033594	response to hydroxyisoflavone
0.42	GO:0032571	response to vitamin K
0.41	GO:0033574	response to testosterone
0.41	GO:0071295	cellular response to vitamin
0.41	GO:0014823	response to activity
0.41	GO:0009629	response to gravity

0.70	GO:0005509	calcium ion binding
0.43	GO:0008147	structural constituent of bone
0.40	GO:0046848	hydroxyapatite binding
0.35	GO:0042803	protein homodimerization activity
0.33	GO:0046914	transition metal ion binding

0.66	GO:0005576	extracellular region
0.44	GO:0005737	cytoplasm
0.40	GO:0043204	perikaryon
0.39	GO:0030425	dendrite
0.38	GO:0031982	vesicle
0.37	GO:0012505	endomembrane system
0.36	GO:0070013	intracellular organelle lumen
0.35	GO:0043231	intracellular membrane-bounded organelle
0.34	GO:0044446	intracellular organelle part

sp|P03372|ESR1_HUMAN
Estrogen receptor
Search

ESR1

0.93	Estrogen receptor

0.78	GO:0043401	steroid hormone mediated signaling pathway
0.60	GO:0060523	prostate epithelial cord elongation
0.60	GO:0071392	cellular response to estradiol stimulus
0.60	GO:0001547	antral ovarian follicle growth
0.59	GO:0060526	prostate glandular acinus morphogenesis
0.59	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA
0.59	GO:0060687	regulation of branching involved in prostate gland morphogenesis
0.59	GO:0060068	vagina development
0.58	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
0.58	GO:0008209	androgen metabolic process

0.85	GO:0030284	estrogen receptor activity
0.82	GO:0005496	steroid binding
0.64	GO:0043565	sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.60	GO:0001093	TFIIB-class transcription factor binding
0.59	GO:0001223	transcription coactivator binding
0.58	GO:0030331	estrogen receptor binding
0.57	GO:0051117	ATPase binding
0.56	GO:0008013	beta-catenin binding

0.61	GO:0005634	nucleus
0.58	GO:0097550	transcriptional preinitiation complex
0.57	GO:0035327	transcriptionally active chromatin
0.48	GO:0070013	intracellular organelle lumen
0.44	GO:0043234	protein complex
0.43	GO:0005886	plasma membrane
0.40	GO:0005737	cytoplasm
0.39	GO:0012505	endomembrane system
0.35	GO:0043204	perikaryon
0.35	GO:0043195	terminal bouton

0.36	EC:2.7.1.153	GO:0046934
0.36	KEGG:R04545	GO:0046934

sp|P03886|NU1M_HUMAN
NADH-ubiquinone oxidoreductase chain 1
Search

ND1

0.44	NADH-ubiquinone oxidoreductase chain 1

0.53	GO:0055114	oxidation-reduction process
0.36	GO:0033194	response to hydroperoxide
0.35	GO:0014070	response to organic cyclic compound
0.34	GO:0042493	response to drug
0.34	GO:0032981	mitochondrial respiratory chain complex I assembly
0.33	GO:0006119	oxidative phosphorylation

0.69	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.33	GO:0005515	protein binding

0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane
0.36	GO:0043025	neuronal cell body
0.36	GO:0030425	dendrite
0.34	GO:0045271	respiratory chain complex I
0.34	GO:0098798	mitochondrial protein complex
0.33	GO:1990204	oxidoreductase complex
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0008137

sp|P03891|NU2M_HUMAN
NADH-ubiquinone oxidoreductase chain 2
Search

ND2

0.42	NADH-ubiquinone oxidoreductase chain 2

0.75	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
0.35	GO:0072593	reactive oxygen species metabolic process
0.34	GO:0032981	mitochondrial respiratory chain complex I assembly

0.69	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.36	GO:0035255	ionotropic glutamate receptor binding
0.35	GO:0019901	protein kinase binding

0.62	GO:0070469	respiratory chain
0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane
0.36	GO:0014069	postsynaptic density
0.34	GO:0030964	NADH dehydrogenase complex
0.34	GO:0098798	mitochondrial protein complex
0.33	GO:1990204	oxidoreductase complex
0.33	GO:0098796	membrane protein complex
0.30	GO:0016021	integral component of membrane

0.69

GO:0008137

sp|P03897|NU3M_HUMAN
NADH-ubiquinone oxidoreductase chain 3
Search

ND3

0.47	NADH-ubiquinone oxidoreductase chain 3

0.53	GO:0055114	oxidation-reduction process
0.36	GO:0071385	cellular response to glucocorticoid stimulus
0.36	GO:0009642	response to light intensity
0.35	GO:0006979	response to oxidative stress
0.34	GO:0032981	mitochondrial respiratory chain complex I assembly
0.33	GO:0006119	oxidative phosphorylation

0.69	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.33	GO:0005515	protein binding

0.61	GO:0070469	respiratory chain
0.61	GO:0031966	mitochondrial membrane
0.34	GO:0030964	NADH dehydrogenase complex
0.34	GO:0098798	mitochondrial protein complex
0.33	GO:1990204	oxidoreductase complex
0.33	GO:0098796	membrane protein complex
0.33	GO:0019866	organelle inner membrane
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0008137

sp|P03901|NU4LM_HUMAN
NADH-ubiquinone oxidoreductase chain 4L
Search

ND4L

0.50	NADH-ubiquinone oxidoreductase chain 4L

0.69

GO:0042773

ATP synthesis coupled electron transport

0.69

GO:0008137

NADH dehydrogenase (ubiquinone) activity

0.61	GO:0005739	mitochondrion
0.36	GO:0045271	respiratory chain complex I
0.35	GO:1990204	oxidoreductase complex
0.34	GO:0031967	organelle envelope
0.34	GO:0031090	organelle membrane
0.30	GO:0016021	integral component of membrane

0.69

GO:0008137

sp|P03905|NU4M_HUMAN
NADH-ubiquinone oxidoreductase chain 4
Search

ND4

0.45	NADH-ubiquinone oxidoreductase chain 4

0.75	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
0.36	GO:0035094	response to nicotine
0.36	GO:0045471	response to ethanol
0.36	GO:0021549	cerebellum development
0.36	GO:0001666	response to hypoxia
0.36	GO:0001701	in utero embryonic development
0.35	GO:0007568	aging
0.34	GO:0032981	mitochondrial respiratory chain complex I assembly

0.69

GO:0008137

NADH dehydrogenase (ubiquinone) activity

0.61	GO:0005739	mitochondrion
0.34	GO:0045271	respiratory chain complex I
0.33	GO:1990204	oxidoreductase complex
0.33	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.69

GO:0008137

sp|P03915|NU5M_HUMAN
NADH-ubiquinone oxidoreductase chain 5
Search

ND5

0.48	NADH-ubiquinone oxidoreductase chain 5

0.69	GO:0042773	ATP synthesis coupled electron transport
0.30	GO:0000302	response to reactive oxygen species
0.30	GO:0070482	response to oxygen levels
0.30	GO:0032981	mitochondrial respiratory chain complex I assembly
0.30	GO:0010243	response to organonitrogen compound
0.30	GO:0042493	response to drug
0.30	GO:0009636	response to toxic substance
0.30	GO:0010035	response to inorganic substance

0.69

GO:0008137

NADH dehydrogenase (ubiquinone) activity

0.62	GO:0070469	respiratory chain
0.62	GO:0031966	mitochondrial membrane
0.62	GO:0019866	organelle inner membrane
0.30	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane
0.30	GO:0030964	NADH dehydrogenase complex
0.30	GO:0097458	neuron part
0.30	GO:0042995	cell projection
0.30	GO:1990204	oxidoreductase complex

0.69

GO:0008137

sp|P03923|NU6M_HUMAN
NADH-ubiquinone oxidoreductase chain 6
Search

ND6

0.50	NADH-ubiquinone oxidoreductase chain 6

0.53	GO:0055114	oxidation-reduction process
0.36	GO:0042220	response to cocaine
0.36	GO:0035094	response to nicotine
0.36	GO:0042542	response to hydrogen peroxide
0.34	GO:0032981	mitochondrial respiratory chain complex I assembly
0.33	GO:0006119	oxidative phosphorylation

0.69

GO:0008137

NADH dehydrogenase (ubiquinone) activity

0.61	GO:0005739	mitochondrion
0.33	GO:0070469	respiratory chain
0.33	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.69

GO:0008137

sp|P03928|ATP8_HUMAN
ATP synthase protein 8
Search

ATP8

0.49	ATP synthase protein 8

0.70	GO:0015985	energy coupled proton transport, down electrochemical gradient
0.70	GO:0006754	ATP biosynthetic process
0.34	GO:0042407	cristae formation
0.34	GO:0006839	mitochondrial transport
0.33	GO:0046907	intracellular transport
0.32	GO:0055114	oxidation-reduction process

0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.34	GO:0008942	nitrite reductase [NAD(P)H] activity
0.34	GO:0016887	ATPase activity

0.78	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
0.30	GO:0016021	integral component of membrane

0.34	EC:1.7.1.4	GO:0008942
0.34	KEGG:R00787 KEGG:R00789	GO:0008942

sp|P03950|ANGI_HUMAN
Angiogenin
Search

ANG

0.97	Angiogenin ribonuclease 1

0.69	GO:0032431	activation of phospholipase A2 activity
0.68	GO:0006651	diacylglycerol biosynthetic process
0.66	GO:0007202	activation of phospholipase C activity
0.64	GO:0048662	negative regulation of smooth muscle cell proliferation
0.64	GO:0009303	rRNA transcription
0.64	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.64	GO:0001938	positive regulation of endothelial cell proliferation
0.63	GO:0001525	angiogenesis
0.62	GO:0050714	positive regulation of protein secretion
0.61	GO:0001666	response to hypoxia

0.66	GO:0004519	endonuclease activity
0.62	GO:0008201	heparin binding
0.58	GO:0004540	ribonuclease activity
0.58	GO:0042803	protein homodimerization activity
0.56	GO:0003779	actin binding
0.55	GO:0005102	receptor binding
0.55	GO:0005507	copper ion binding
0.51	GO:0003676	nucleic acid binding
0.49	GO:0042277	peptide binding
0.32	GO:0008168	methyltransferase activity

0.68	GO:0032311	angiogenin-PRI complex
0.65	GO:0005605	basal lamina
0.57	GO:0005615	extracellular space
0.54	GO:0031982	vesicle
0.54	GO:0005730	nucleolus
0.47	GO:0030426	growth cone
0.46	GO:0043025	neuronal cell body
0.44	GO:0044444	cytoplasmic part
0.40	GO:0043230	extracellular organelle
0.36	GO:0012505	endomembrane system

0.32

GO:0008168

sp|P03951|FA11_HUMAN
Coagulation factor XI
Search

F11

0.85	Coagulation factor XI

0.80	GO:0007596	blood coagulation
0.67	GO:0051919	positive regulation of fibrinolysis
0.63	GO:0031639	plasminogen activation
0.54	GO:0072376	protein activation cascade
0.37	GO:0042730	fibrinolysis
0.36	GO:0006954	inflammatory response
0.36	GO:0002675	positive regulation of acute inflammatory response
0.36	GO:0022617	extracellular matrix disassembly
0.36	GO:0010954	positive regulation of protein processing
0.33	GO:0055114	oxidation-reduction process

0.69	GO:0004252	serine-type endopeptidase activity
0.37	GO:0070009	serine-type aminopeptidase activity
0.37	GO:0008201	heparin binding
0.36	GO:0042802	identical protein binding
0.35	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.34	GO:0020037	heme binding
0.34	GO:0005506	iron ion binding
0.34	GO:0004497	monooxygenase activity
0.32	GO:0008061	chitin binding
0.32	GO:0046983	protein dimerization activity

0.65	GO:0005576	extracellular region
0.37	GO:0031982	vesicle
0.34	GO:0005886	plasma membrane
0.33	GO:0097223	sperm part
0.32	GO:0012505	endomembrane system
0.31	GO:0044444	cytoplasmic part
0.31	GO:0043229	intracellular organelle
0.30	GO:0016021	integral component of membrane

0.69

GO:0004252

sp|P03952|KLKB1_HUMAN
Plasma kallikrein
Search

F11

0.77	Coagulation factor XI

0.82	GO:0007596	blood coagulation
0.63	GO:0051919	positive regulation of fibrinolysis
0.61	GO:0006508	proteolysis
0.52	GO:0051604	protein maturation
0.34	GO:0072376	protein activation cascade

0.69	GO:0004252	serine-type endopeptidase activity
0.40	GO:0008201	heparin binding
0.36	GO:0070009	serine-type aminopeptidase activity
0.35	GO:0042802	identical protein binding

0.66	GO:0005576	extracellular region
0.34	GO:0031982	vesicle
0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.69

GO:0004252

sp|P03956|MMP1_HUMAN
Interstitial collagenase
Search

MMP1

0.57	interstitial collagenase A

0.60	GO:0006508	proteolysis
0.55	GO:0032461	positive regulation of protein oligomerization
0.45	GO:0030574	collagen catabolic process
0.44	GO:0035987	endodermal cell differentiation
0.37	GO:0022617	extracellular matrix disassembly
0.36	GO:0016477	cell migration
0.36	GO:0071345	cellular response to cytokine stimulus
0.36	GO:0002376	immune system process
0.35	GO:0071283	cellular response to iron(III) ion
0.35	GO:0001554	luteolysis

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.40	GO:0004252	serine-type endopeptidase activity
0.34	GO:0005518	collagen binding
0.34	GO:0001047	core promoter binding
0.33	GO:0005509	calcium ion binding
0.33	GO:0043565	sequence-specific DNA binding

0.74	GO:0031012	extracellular matrix
0.42	GO:0005615	extracellular space
0.41	GO:0005581	collagen trimer
0.35	GO:1904724	tertiary granule lumen
0.35	GO:0035580	specific granule lumen
0.32	GO:0005634	nucleus
0.30	GO:0044425	membrane part

0.70

GO:0004222

sp|P03971|MIS_HUMAN
Muellerian-inhibiting factor
Search

AMH

0.85	Muellerian-inhibiting factor

0.83	GO:0008406	gonad development
0.76	GO:0010469	regulation of receptor activity
0.75	GO:0001880	Mullerian duct regression
0.64	GO:0007498	mesoderm development
0.63	GO:0060485	mesenchyme development
0.62	GO:0001655	urogenital system development
0.58	GO:0007267	cell-cell signaling
0.58	GO:2000355	negative regulation of ovarian follicle development
0.58	GO:0048162	multi-layer follicle stage
0.54	GO:0010628	positive regulation of gene expression

0.78	GO:0008083	growth factor activity
0.61	GO:0005179	hormone activity
0.58	GO:0005160	transforming growth factor beta receptor binding
0.37	GO:0008270	zinc ion binding
0.34	GO:0003676	nucleic acid binding

0.66	GO:0005576	extracellular region
0.37	GO:0005737	cytoplasm
0.36	GO:0005634	nucleus

sp|P03973|SLPI_HUMAN
Antileukoproteinase
Search

SLPI

0.82	Antileukoproteinase

0.76	GO:0010466	negative regulation of peptidase activity
0.61	GO:0019731	antibacterial humoral response
0.56	GO:0045071	negative regulation of viral genome replication
0.55	GO:0032091	negative regulation of protein binding
0.55	GO:0052548	regulation of endopeptidase activity
0.51	GO:0032496	response to lipopolysaccharide
0.50	GO:0045087	innate immune response
0.48	GO:0035821	modification of morphology or physiology of other organism
0.46	GO:0043312	neutrophil degranulation

0.76	GO:0030414	peptidase inhibitor activity
0.56	GO:0061135	endopeptidase regulator activity
0.51	GO:0003729	mRNA binding
0.49	GO:0019899	enzyme binding
0.41	GO:0003677	DNA binding

0.66	GO:0005576	extracellular region
0.47	GO:0035580	specific granule lumen

sp|P03979|TRGV3_HUMAN
T cell receptor gamma variable 3 (Fragment)
Search

0.97	T-cell receptor gamma variable 3

0.74

GO:0006955

immune response

0.86	GO:0042605	peptide antigen binding
0.85	GO:0042287	MHC protein binding

0.56

GO:0005886

plasma membrane

sp|P03986|TRGC2_HUMAN
T-cell receptor gamma-2 chain C region
Search

0.97	T-cell receptor gamma-2 chain C region

0.47	GO:0006955	immune response
0.42	GO:0007165	signal transduction

0.46	GO:0099600	transmembrane receptor activity
0.44	GO:0038023	signaling receptor activity

0.45

GO:0005887

integral component of plasma membrane

sp|P03999|OPSB_HUMAN
Short-wave-sensitive opsin 1
Search

SWS1

0.97	Short wavelength-sensitive opsin

0.78	GO:0007602	phototransduction
0.77	GO:0007601	visual perception
0.73	GO:0018298	protein-chromophore linkage
0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.51	GO:0016038	absorption of visible light
0.42	GO:0009584	detection of visible light
0.35	GO:0001523	retinoid metabolic process

0.78	GO:0009881	photoreceptor activity
0.71	GO:0004930	G-protein coupled receptor activity

0.52	GO:0001750	photoreceptor outer segment
0.35	GO:0060170	ciliary membrane
0.35	GO:0043195	terminal bouton
0.34	GO:0044297	cell body
0.33	GO:0005887	integral component of plasma membrane

sp|P04000|OPSR_HUMAN
Long-wave-sensitive opsin 1
Search

0.91	Red-green sensitive cone visual pigment

0.79	GO:0007602	phototransduction
0.78	GO:0007601	visual perception
0.75	GO:0018298	protein-chromophore linkage
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.42	GO:0009584	detection of visible light
0.39	GO:0032467	positive regulation of cytokinesis
0.37	GO:0016038	absorption of visible light
0.37	GO:0001523	retinoid metabolic process
0.36	GO:0070207	protein homotrimerization
0.35	GO:0016039	absorption of UV light

0.79	GO:0009881	photoreceptor activity
0.72	GO:0004930	G-protein coupled receptor activity
0.40	GO:0042802	identical protein binding
0.37	GO:0031404	chloride ion binding
0.34	GO:0046983	protein dimerization activity

0.53	GO:0001750	photoreceptor outer segment
0.38	GO:0098590	plasma membrane region
0.36	GO:0001917	photoreceptor inner segment
0.36	GO:0044297	cell body
0.35	GO:0098588	bounding membrane of organelle
0.35	GO:0031982	vesicle
0.35	GO:0005794	Golgi apparatus
0.35	GO:0005887	integral component of plasma membrane

sp|P04001|OPSG_HUMAN
Medium-wave-sensitive opsin 1
Search

0.90	Long wavelength sensitive visual pigment

0.79	GO:0007602	phototransduction
0.78	GO:0007601	visual perception
0.75	GO:0018298	protein-chromophore linkage
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.43	GO:0009584	detection of visible light
0.39	GO:0032467	positive regulation of cytokinesis
0.37	GO:0016038	absorption of visible light
0.37	GO:0001523	retinoid metabolic process
0.36	GO:0070207	protein homotrimerization
0.35	GO:0016039	absorption of UV light

0.79	GO:0009881	photoreceptor activity
0.72	GO:0004930	G-protein coupled receptor activity
0.40	GO:0042802	identical protein binding
0.37	GO:0031404	chloride ion binding
0.34	GO:0046983	protein dimerization activity

0.53	GO:0001750	photoreceptor outer segment
0.38	GO:0098590	plasma membrane region
0.36	GO:0001917	photoreceptor inner segment
0.36	GO:0044297	cell body
0.35	GO:0098588	bounding membrane of organelle
0.35	GO:0031982	vesicle
0.35	GO:0005794	Golgi apparatus
0.35	GO:0005887	integral component of plasma membrane

sp|P04003|C4BPA_HUMAN
C4b-binding protein alpha chain
Search

C4BPA

0.94	Zona pellucida sperm-binding protein 3 receptor

0.86	GO:0045959	negative regulation of complement activation, classical pathway
0.76	GO:0045732	positive regulation of protein catabolic process
0.53	GO:0006958	complement activation, classical pathway
0.50	GO:0045087	innate immune response
0.48	GO:0007339	binding of sperm to zona pellucida
0.47	GO:1903027	regulation of opsonization
0.39	GO:0006003	fructose 2,6-bisphosphate metabolic process
0.39	GO:0006000	fructose metabolic process
0.37	GO:0046835	carbohydrate phosphorylation
0.36	GO:0007340	acrosome reaction

0.43	GO:0005515	protein binding
0.40	GO:0003723	RNA binding
0.39	GO:0003873	6-phosphofructo-2-kinase activity
0.35	GO:0005198	structural molecule activity
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0032555	purine ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005509	calcium ion binding
0.33	GO:0003682	chromatin binding

0.70	GO:0005615	extracellular space
0.61	GO:0044216	other organism cell
0.51	GO:0043159	acrosomal matrix
0.48	GO:0043160	acrosomal lumen
0.47	GO:0002081	outer acrosomal membrane
0.46	GO:0002199	zona pellucida receptor complex
0.43	GO:0044297	cell body
0.40	GO:0005886	plasma membrane
0.34	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

0.39	EC:2.7.1.105	GO:0003873
0.39	KEGG:R02732	GO:0003873

sp|P04004|VTNC_HUMAN
Vitronectin
Search

VTN

0.96	Serum-spreading factor

0.70	GO:0006955	immune response
0.69	GO:0006898	receptor-mediated endocytosis
0.65	GO:0061302	smooth muscle cell-matrix adhesion
0.63	GO:0014911	positive regulation of smooth muscle cell migration
0.62	GO:0033627	cell adhesion mediated by integrin
0.62	GO:0048709	oligodendrocyte differentiation
0.61	GO:0010811	positive regulation of cell-substrate adhesion
0.61	GO:0035987	endodermal cell differentiation
0.61	GO:0048260	positive regulation of receptor-mediated endocytosis
0.60	GO:0032092	positive regulation of protein binding

0.77	GO:0005044	scavenger receptor activity
0.74	GO:0001871	pattern binding
0.67	GO:0030246	carbohydrate binding
0.61	GO:0050840	extracellular matrix binding
0.60	GO:0005178	integrin binding
0.45	GO:0008201	heparin binding
0.43	GO:0005518	collagen binding
0.41	GO:0042802	identical protein binding
0.35	GO:0046872	metal ion binding
0.34	GO:0003677	DNA binding

0.56	GO:0005578	proteinaceous extracellular matrix
0.55	GO:0005615	extracellular space
0.53	GO:0005783	endoplasmic reticulum
0.45	GO:0005796	Golgi lumen
0.43	GO:0044420	extracellular matrix component
0.40	GO:1903561	extracellular vesicle
0.39	GO:0071062	alphav-beta3 integrin-vitronectin complex
0.34	GO:0005634	nucleus

sp|P04035|HMDH_HUMAN
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Search

HMGCR

0.56	3-hydroxy-3-methylglutaryl-coenzyme A reductase

0.74	GO:0015936	coenzyme A metabolic process
0.71	GO:0008299	isoprenoid biosynthetic process
0.58	GO:0006695	cholesterol biosynthetic process
0.56	GO:0008542	visual learning
0.54	GO:0043407	negative regulation of MAP kinase activity
0.53	GO:0051262	protein tetramerization
0.52	GO:0055114	oxidation-reduction process
0.41	GO:0061061	muscle structure development
0.40	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
0.40	GO:0010666	positive regulation of cardiac muscle cell apoptotic process

0.82	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity
0.69	GO:0050661	NADP binding
0.56	GO:0042282	hydroxymethylglutaryl-CoA reductase activity
0.40	GO:0043168	anion binding
0.39	GO:0051721	protein phosphatase 2A binding
0.38	GO:0042803	protein homodimerization activity

0.72	GO:0005789	endoplasmic reticulum membrane
0.54	GO:0031903	microbody membrane
0.54	GO:0044439	peroxisomal part
0.30	GO:0016021	integral component of membrane

0.82	EC:1.1.1.34	GO:0004420
0.82	KEGG:R02082	GO:0004420

sp|P04040|CATA_HUMAN
Catalase
Search

CAT

0.54

Catalase

0.76	GO:0042744	hydrogen peroxide catabolic process
0.71	GO:0006979	response to oxidative stress
0.69	GO:0098869	cellular oxidant detoxification
0.55	GO:0009650	UV protection
0.55	GO:0020027	hemoglobin metabolic process
0.53	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
0.53	GO:0051289	protein homotetramerization
0.53	GO:0032088	negative regulation of NF-kappaB transcription factor activity
0.53	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.53	GO:0055114	oxidation-reduction process

0.77	GO:0004096	catalase activity
0.63	GO:0020037	heme binding
0.53	GO:0004046	aminoacylase activity
0.53	GO:0046872	metal ion binding
0.49	GO:0042803	protein homodimerization activity
0.48	GO:0005102	receptor binding
0.48	GO:0019899	enzyme binding
0.47	GO:0050661	NADP binding
0.35	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity

0.52	GO:0005777	peroxisome
0.51	GO:0031903	microbody membrane
0.44	GO:0005739	mitochondrion
0.37	GO:0031970	organelle envelope lumen
0.37	GO:0005764	lysosome
0.36	GO:0005615	extracellular space
0.36	GO:0005925	focal adhesion
0.36	GO:1903561	extracellular vesicle
0.36	GO:0005794	Golgi apparatus
0.36	GO:0005783	endoplasmic reticulum

0.77

EC:1.11.1.6

GO:0004096

sp|P04049|RAF1_HUMAN
RAF proto-oncogene serine/threonine-protein kinase
Search

RAF1

0.92	RAF proto-oncogene serine/threonine-protein kinase

0.63	GO:0006468	protein phosphorylation
0.61	GO:0035556	intracellular signal transduction
0.49	GO:0000186	activation of MAPKK activity
0.48	GO:0071550	death-inducing signaling complex assembly
0.47	GO:0035773	insulin secretion involved in cellular response to glucose stimulus
0.47	GO:0035994	response to muscle stretch
0.47	GO:0043066	negative regulation of apoptotic process
0.47	GO:0048011	neurotrophin TRK receptor signaling pathway
0.47	GO:0007190	activation of adenylate cyclase activity
0.46	GO:0030878	thyroid gland development

0.77	GO:0005057	signal transducer activity, downstream of receptor
0.69	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0032555	purine ribonucleotide binding
0.53	GO:0046872	metal ion binding
0.47	GO:0031434	mitogen-activated protein kinase kinase binding
0.44	GO:0010856	adenylate cyclase activator activity
0.43	GO:0031267	small GTPase binding

0.46	GO:0031143	pseudopodium
0.44	GO:0005622	intracellular
0.40	GO:0012505	endomembrane system
0.40	GO:0031974	membrane-enclosed lumen
0.39	GO:0005886	plasma membrane
0.38	GO:0043227	membrane-bounded organelle
0.38	GO:0044422	organelle part
0.35	GO:0098805	whole membrane
0.35	GO:0019867	outer membrane
0.34	GO:0031975	envelope

0.69

GO:0004674

sp|P04053|TDT_HUMAN
DNA nucleotidylexotransferase
Search

DNTT

0.97	DNA nucleotidylexotransferase

0.63	GO:0071897	DNA biosynthetic process
0.41	GO:0006304	DNA modification
0.40	GO:0033198	response to ATP
0.38	GO:0006281	DNA repair

0.82	GO:0003912	DNA nucleotidylexotransferase activity
0.66	GO:0003887	DNA-directed DNA polymerase activity
0.52	GO:0003677	DNA binding
0.51	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.58	GO:0005634	nucleus
0.50	GO:0005829	cytosol
0.50	GO:0031974	membrane-enclosed lumen
0.45	GO:0044446	intracellular organelle part
0.37	GO:0005694	chromosome

0.82

EC:2.7.7.31

GO:0003912

sp|P04054|PA21B_HUMAN
Phospholipase A2
Search

PLA2G1B

0.68	Phospholipase A2, major isoenzyme

0.82	GO:0050482	arachidonic acid secretion
0.72	GO:0016042	lipid catabolic process
0.67	GO:0006644	phospholipid metabolic process
0.55	GO:0002227	innate immune response in mucosa
0.55	GO:0044241	lipid digestion
0.54	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
0.54	GO:0044243	multicellular organismal catabolic process
0.54	GO:0019731	antibacterial humoral response
0.54	GO:0045740	positive regulation of DNA replication
0.53	GO:0050830	defense response to Gram-positive bacterium

0.82	GO:0004623	phospholipase A2 activity
0.79	GO:0102568	phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
0.79	GO:0102567	phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
0.70	GO:0005509	calcium ion binding
0.48	GO:0005102	receptor binding
0.43	GO:0090729	toxin activity
0.37	GO:0032052	bile acid binding
0.34	GO:0003723	RNA binding
0.34	GO:0008061	chitin binding
0.33	GO:0008168	methyltransferase activity

0.66	GO:0005576	extracellular region
0.49	GO:0009986	cell surface
0.46	GO:0005829	cytosol
0.38	GO:0030141	secretory granule
0.30	GO:0016020	membrane

0.82

EC:3.1.1.4

GO:0004623

sp|P04062|GLCM_HUMAN
Glucosylceramidase
Search

GBA

0.74	Glucosylceramidase

0.78	GO:0006665	sphingolipid metabolic process
0.62	GO:1904457	positive regulation of neuronal action potential
0.61	GO:0023021	termination of signal transduction
0.60	GO:1903061	positive regulation of protein lipidation
0.60	GO:0032463	negative regulation of protein homooligomerization
0.59	GO:0019377	glycolipid catabolic process
0.58	GO:0032715	negative regulation of interleukin-6 production
0.57	GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
0.57	GO:0035307	positive regulation of protein dephosphorylation
0.56	GO:0043407	negative regulation of MAP kinase activity

0.81	GO:0004348	glucosylceramidase activity
0.61	GO:0005124	scavenger receptor binding

0.58	GO:0005764	lysosome
0.56	GO:0098852	lytic vacuole membrane
0.56	GO:0005775	vacuolar lumen
0.50	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.35	GO:0019898	extrinsic component of membrane
0.30	GO:0016021	integral component of membrane

0.81

EC:3.2.1.45

GO:0004348

sp|P04066|FUCO_HUMAN
Tissue alpha-L-fucosidase
Search

FUCA1

0.90	Tissue alpha-L-fucosidase

0.79	GO:0006004	fucose metabolic process
0.58	GO:0016139	glycoside catabolic process
0.37	GO:0019377	glycolipid catabolic process
0.36	GO:2000535	regulation of entry of bacterium into host cell
0.36	GO:0043312	neutrophil degranulation
0.35	GO:0009617	response to bacterium
0.34	GO:0006027	glycosaminoglycan catabolic process
0.34	GO:0006471	protein ADP-ribosylation
0.32	GO:0038171	cannabinoid signaling pathway

0.80	GO:0004560	alpha-L-fucosidase activity
0.35	GO:0004419	hydroxymethylglutaryl-CoA lyase activity
0.34	GO:0003950	NAD+ ADP-ribosyltransferase activity
0.34	GO:0030246	carbohydrate binding
0.32	GO:0004949	cannabinoid receptor activity
0.32	GO:0003676	nucleic acid binding

0.40	GO:0005764	lysosome
0.37	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.36	GO:0034774	secretory granule lumen
0.36	GO:0005775	vacuolar lumen
0.30	GO:0031224	intrinsic component of membrane

0.80	EC:3.2.1.51	GO:0004560
0.35	KEGG:R01360	GO:0004419

sp|P04070|PROC_HUMAN
Vitamin K-dependent protein C
Search

PROC

0.96	Vitamin K-dependent protein C

0.76	GO:0007596	blood coagulation
0.61	GO:1901552	positive regulation of endothelial cell development
0.60	GO:0050819	negative regulation of coagulation
0.60	GO:0006508	proteolysis
0.60	GO:1903140	regulation of establishment of endothelial barrier
0.59	GO:1900047	negative regulation of hemostasis
0.59	GO:0061045	negative regulation of wound healing
0.58	GO:0030193	regulation of blood coagulation
0.58	GO:0044537	regulation of circulating fibrinogen levels
0.57	GO:0050728	negative regulation of inflammatory response

0.68	GO:0004252	serine-type endopeptidase activity
0.66	GO:0005509	calcium ion binding
0.37	GO:0070012	oligopeptidase activity
0.36	GO:0043621	protein self-association
0.34	GO:0004143	diacylglycerol kinase activity
0.34	GO:0016504	peptidase activator activity
0.34	GO:0003951	NAD+ kinase activity
0.33	GO:0090729	toxin activity
0.33	GO:0003677	DNA binding
0.32	GO:0030554	adenyl nucleotide binding

0.64	GO:0005576	extracellular region
0.51	GO:0005794	Golgi apparatus
0.50	GO:0005783	endoplasmic reticulum
0.35	GO:0043233	organelle lumen
0.35	GO:1905286	serine-type peptidase complex
0.34	GO:0044446	intracellular organelle part
0.34	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.68	EC:3.4.21	GO:0004252
0.34	KEGG:R00104	GO:0003951

sp|P04075|ALDOA_HUMAN
Fructose-bisphosphate aldolase A
Search

ALDOA

0.54	Fructose-bisphosphate aldolase A

0.70	GO:0006096	glycolytic process
0.55	GO:0030388	fructose 1,6-bisphosphate metabolic process
0.48	GO:0030855	epithelial cell differentiation
0.48	GO:0046716	muscle cell cellular homeostasis
0.48	GO:0007339	binding of sperm to zona pellucida
0.47	GO:0006000	fructose metabolic process
0.47	GO:0006941	striated muscle contraction
0.42	GO:0006754	ATP biosynthetic process
0.42	GO:0008360	regulation of cell shape
0.41	GO:0051289	protein homotetramerization

0.79	GO:0004332	fructose-bisphosphate aldolase activity
0.50	GO:0070061	fructose binding
0.50	GO:0008092	cytoskeletal protein binding
0.46	GO:0045296	cadherin binding
0.37	GO:0042802	identical protein binding
0.36	GO:0002020	protease binding
0.35	GO:0061609	fructose-1-phosphate aldolase activity
0.35	GO:0051117	ATPase binding
0.34	GO:0003723	RNA binding
0.33	GO:0004672	protein kinase activity

0.49	GO:0061827	sperm head
0.46	GO:0070062	extracellular exosome
0.44	GO:0005829	cytosol
0.43	GO:0015629	actin cytoskeleton
0.41	GO:0005739	mitochondrion
0.41	GO:0031430	M band
0.40	GO:0031674	I band
0.40	GO:0035686	sperm fibrous sheath
0.37	GO:1904724	tertiary granule lumen
0.37	GO:1904813	ficolin-1-rich granule lumen

0.79

EC:4.1.2.13

GO:0004332

sp|P04080|CYTB_HUMAN
Cystatin-B
Search

CSTB

0.91	LOW QUALITY PROTEIN: cystatin-B

0.76	GO:0010951	negative regulation of endopeptidase activity
0.48	GO:0008344	adult locomotory behavior
0.36	GO:0030216	keratinocyte differentiation
0.36	GO:0018149	peptide cross-linking
0.36	GO:0043312	neutrophil degranulation
0.35	GO:0098609	cell-cell adhesion
0.34	GO:0071220	cellular response to bacterial lipoprotein
0.33	GO:0045087	innate immune response
0.33	GO:0043043	peptide biosynthetic process
0.33	GO:0007017	microtubule-based process

0.82	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.52	GO:0002020	protease binding
0.35	GO:0030674	protein binding, bridging
0.34	GO:0005198	structural molecule activity
0.34	GO:0003723	RNA binding
0.32	GO:0004930	G-protein coupled receptor activity
0.32	GO:0008168	methyltransferase activity
0.32	GO:0008233	peptidase activity

0.47	GO:0005615	extracellular space
0.47	GO:0005730	nucleolus
0.46	GO:0005829	cytosol
0.36	GO:1903561	extracellular vesicle
0.36	GO:1904724	tertiary granule lumen
0.36	GO:0001533	cornified envelope
0.36	GO:1904813	ficolin-1-rich granule lumen
0.36	GO:0034774	secretory granule lumen
0.33	GO:0030286	dynein complex
0.33	GO:0005840	ribosome

0.32

GO:0008168

sp|P04083|ANXA1_HUMAN
Annexin A1
Search

ANXA1

0.60

Annexin

0.72	GO:0043086	negative regulation of catalytic activity
0.63	GO:0045629	negative regulation of T-helper 2 cell differentiation
0.62	GO:0045627	positive regulation of T-helper 1 cell differentiation
0.61	GO:0002548	monocyte chemotaxis
0.60	GO:0045920	negative regulation of exocytosis
0.60	GO:0014839	myoblast migration involved in skeletal muscle regeneration
0.60	GO:0032743	positive regulation of interleukin-2 production
0.60	GO:0071385	cellular response to glucocorticoid stimulus
0.60	GO:0097350	neutrophil clearance
0.60	GO:0033031	positive regulation of neutrophil apoptotic process

0.85	GO:0004859	phospholipase inhibitor activity
0.81	GO:0005544	calcium-dependent phospholipid binding
0.70	GO:0005509	calcium ion binding
0.58	GO:0098641	cadherin binding involved in cell-cell adhesion
0.57	GO:0048306	calcium-dependent protein binding
0.54	GO:0030674	protein binding, bridging
0.45	GO:0005198	structural molecule activity
0.42	GO:0033676	double-stranded DNA-dependent ATPase activity
0.41	GO:0036310	annealing helicase activity
0.39	GO:0003727	single-stranded RNA binding

0.62	GO:0031232	extrinsic component of external side of plasma membrane
0.59	GO:0016328	lateral plasma membrane
0.57	GO:0001533	cornified envelope
0.56	GO:0016324	apical plasma membrane
0.56	GO:0070062	extracellular exosome
0.56	GO:0042383	sarcolemma
0.56	GO:0031514	motile cilium
0.56	GO:0005913	cell-cell adherens junction
0.55	GO:0005884	actin filament
0.54	GO:0005768	endosome

sp|P04085|PDGFA_HUMAN
Platelet-derived growth factor subunit A
Search

PDGFA

0.96	Platelet-derived growth factor alpha polypeptide b

0.74	GO:0010469	regulation of receptor activity
0.59	GO:1900238	regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
0.59	GO:2000591	positive regulation of metanephric mesenchymal cell migration
0.58	GO:0031954	positive regulation of protein autophosphorylation
0.57	GO:0010512	negative regulation of phosphatidylinositol biosynthetic process
0.57	GO:0010544	negative regulation of platelet activation
0.57	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
0.56	GO:0014910	regulation of smooth muscle cell migration
0.56	GO:0050919	negative chemotaxis
0.56	GO:0070374	positive regulation of ERK1 and ERK2 cascade

0.77	GO:0008083	growth factor activity
0.59	GO:0005161	platelet-derived growth factor receptor binding
0.56	GO:0048407	platelet-derived growth factor binding
0.54	GO:0005518	collagen binding
0.50	GO:0042803	protein homodimerization activity
0.49	GO:0046982	protein heterodimerization activity
0.36	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.35	GO:0005088	Ras guanyl-nucleotide exchange factor activity

0.51	GO:0005615	extracellular space
0.51	GO:0009986	cell surface
0.39	GO:0005902	microvillus
0.36	GO:0031093	platelet alpha granule lumen
0.36	GO:0005796	Golgi lumen
0.35	GO:0005788	endoplasmic reticulum lumen
0.34	GO:0000139	Golgi membrane

0.36	EC:2.7.1.153	GO:0046934
0.36	KEGG:R04545	GO:0046934

sp|P04090|REL2_HUMAN
Prorelaxin H2
Search

0.93	Prorelaxin

0.76	GO:0010469	regulation of receptor activity
0.57	GO:0030819	positive regulation of cAMP biosynthetic process
0.56	GO:0044703	multi-organism reproductive process
0.55	GO:0045766	positive regulation of angiogenesis
0.53	GO:0044706	multi-multicellular organism process
0.49	GO:0010628	positive regulation of gene expression
0.48	GO:0050790	regulation of catalytic activity
0.47	GO:0007186	G-protein coupled receptor signaling pathway
0.47	GO:0048589	developmental growth
0.46	GO:0048609	multicellular organismal reproductive process

0.79

GO:0005179

hormone activity

0.66

GO:0005576

extracellular region

sp|P04114|APOB_HUMAN
Apolipoprotein B-100
Search

APOB

0.83	Apolipoprotein B

0.74	GO:0006869	lipid transport
0.67	GO:0010886	positive regulation of cholesterol storage
0.67	GO:0034374	low-density lipoprotein particle remodeling
0.67	GO:0034383	low-density lipoprotein particle clearance
0.67	GO:0010744	positive regulation of macrophage derived foam cell differentiation
0.66	GO:0045540	regulation of cholesterol biosynthetic process
0.66	GO:0006642	triglyceride mobilization
0.65	GO:0019433	triglyceride catabolic process
0.64	GO:0042632	cholesterol homeostasis
0.64	GO:0048844	artery morphogenesis

0.77	GO:0005319	lipid transporter activity
0.68	GO:0035473	lipase binding
0.65	GO:0050750	low-density lipoprotein particle receptor binding
0.62	GO:0008201	heparin binding
0.57	GO:0005543	phospholipid binding

0.70	GO:0034359	mature chylomicron
0.68	GO:0034363	intermediate-density lipoprotein particle
0.67	GO:0034362	low-density lipoprotein particle
0.65	GO:0070971	endoplasmic reticulum exit site
0.65	GO:0034361	very-low-density lipoprotein particle
0.61	GO:0043025	neuronal cell body
0.54	GO:0005829	cytosol
0.44	GO:0034360	chylomicron remnant
0.43	GO:0031983	vesicle lumen
0.42	GO:0031904	endosome lumen

sp|P04118|COL_HUMAN
Colipase
Search

CLPS

0.97	Pancreatic colipase

0.84	GO:0007586	digestion
0.73	GO:0043085	positive regulation of catalytic activity
0.72	GO:0016042	lipid catabolic process
0.54	GO:0032094	response to food
0.38	GO:0001523	retinoid metabolic process
0.38	GO:0050821	protein stabilization
0.36	GO:0009791	post-embryonic development

0.75

GO:0008047

enzyme activator activity

0.66	GO:0005576	extracellular region
0.38	GO:0031982	vesicle

sp|P04141|CSF2_HUMAN
Granulocyte-macrophage colony-stimulating factor
Search

CSF2

0.97	Granulocyte-macrophage colony-stimulating factor

0.76	GO:0010469	regulation of receptor activity
0.74	GO:0006955	immune response
0.70	GO:0045918	negative regulation of cytolysis
0.69	GO:0032747	positive regulation of interleukin-23 production
0.69	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus
0.68	GO:0010744	positive regulation of macrophage derived foam cell differentiation
0.68	GO:0071803	positive regulation of podosome assembly
0.68	GO:0043011	myeloid dendritic cell differentiation
0.67	GO:1901099	negative regulation of signal transduction in absence of ligand
0.66	GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand

0.87	GO:0005129	granulocyte macrophage colony-stimulating factor receptor binding
0.78	GO:0008083	growth factor activity
0.65	GO:0005125	cytokine activity
0.37	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.37	GO:0004713	protein tyrosine kinase activity

0.66	GO:0005576	extracellular region
0.46	GO:0043227	membrane-bounded organelle
0.44	GO:0043229	intracellular organelle

0.37

GO:0004713

sp|P04150|GCR_HUMAN
Glucocorticoid receptor
Search

NR3C1

0.87	Glucocorticoid receptor variant gamma

0.86	GO:0043402	glucocorticoid mediated signaling pathway
0.85	GO:0042921	glucocorticoid receptor signaling pathway
0.60	GO:0071549	cellular response to dexamethasone stimulus
0.58	GO:0097659	nucleic acid-templated transcription
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:0071560	cellular response to transforming growth factor beta stimulus
0.56	GO:0010468	regulation of gene expression
0.54	GO:1902680	positive regulation of RNA biosynthetic process
0.53	GO:0010467	gene expression

0.86	GO:0004883	glucocorticoid receptor activity
0.81	GO:0005496	steroid binding
0.67	GO:0038049	transcription factor activity, ligand-activated RNA polymerase II transcription factor binding
0.64	GO:0043565	sequence-specific DNA binding
0.62	GO:0008270	zinc ion binding
0.61	GO:0003700	DNA binding transcription factor activity
0.61	GO:0042562	hormone binding
0.60	GO:0032183	SUMO binding
0.60	GO:0051879	Hsp90 protein binding
0.57	GO:0001047	core promoter binding

0.61	GO:0005634	nucleus
0.52	GO:0070013	intracellular organelle lumen
0.51	GO:0005829	cytosol
0.46	GO:0044446	intracellular organelle part
0.45	GO:0043234	protein complex
0.43	GO:0015630	microtubule cytoskeleton
0.40	GO:0005739	mitochondrion
0.35	GO:0043197	dendritic spine
0.35	GO:0014069	postsynaptic density
0.30	GO:0016020	membrane

sp|P04155|TFF1_HUMAN
Trefoil factor 1
Search

TFF1

0.94	Trefoil factor 1

0.83	GO:0030277	maintenance of gastrointestinal epithelium
0.65	GO:0008285	negative regulation of cell proliferation
0.60	GO:0030154	cell differentiation
0.56	GO:0042060	wound healing
0.46	GO:0010469	regulation of receptor activity
0.46	GO:0035902	response to immobilization stress
0.44	GO:0010039	response to iron ion
0.43	GO:0043434	response to peptide hormone
0.42	GO:0005975	carbohydrate metabolic process

0.47	GO:0008083	growth factor activity
0.42	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.42	GO:0030246	carbohydrate binding
0.34	GO:0043169	cation binding

0.53	GO:0005615	extracellular space
0.34	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.42

EC:3.2.1

GO:0004553

sp|P04156|PRIO_HUMAN
Major prion protein
Search

PRNP

0.85	Major prion protein (Fragment)

0.78	GO:0051260	protein homooligomerization
0.51	GO:1902938	regulation of intracellular calcium activated chloride channel activity
0.51	GO:0071280	cellular response to copper ion
0.50	GO:1904646	cellular response to amyloid-beta
0.50	GO:0035584	calcium-mediated signaling using intracellular calcium source
0.50	GO:1902951	negative regulation of dendritic spine maintenance
0.50	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade
0.50	GO:1990535	neuron projection maintenance
0.50	GO:1902430	negative regulation of amyloid-beta formation
0.50	GO:0043525	positive regulation of neuron apoptotic process

0.54	GO:0046872	metal ion binding
0.52	GO:0031802	type 5 metabotropic glutamate receptor binding
0.50	GO:0001540	amyloid-beta binding
0.47	GO:0002020	protease binding
0.46	GO:0032403	protein complex binding
0.45	GO:0042802	identical protein binding
0.45	GO:0008017	microtubule binding
0.45	GO:0005539	glycosaminoglycan binding
0.41	GO:0004872	receptor activity
0.41	GO:0004871	signal transducer activity

0.58	GO:0098857	membrane microdomain
0.56	GO:0005886	plasma membrane
0.54	GO:0031225	anchored component of membrane
0.52	GO:0005794	Golgi apparatus
0.50	GO:0106003	amyloid-beta complex
0.48	GO:0016234	inclusion body
0.48	GO:0031965	nuclear membrane
0.48	GO:0030425	dendrite
0.46	GO:0009986	cell surface
0.44	GO:0005829	cytosol

sp|P04179|SODM_HUMAN
Superoxide dismutase [Mn], mitochondrial
Search

SOD2

0.46	Superoxide dismutase

0.75	GO:0071450	cellular response to oxygen radical
0.75	GO:0000303	response to superoxide
0.75	GO:0006801	superoxide metabolic process
0.69	GO:0098869	cellular oxidant detoxification
0.53	GO:0001306	age-dependent response to oxidative stress
0.52	GO:0055114	oxidation-reduction process
0.50	GO:0003070	regulation of systemic arterial blood pressure by neurotransmitter
0.49	GO:0048773	erythrophore differentiation
0.47	GO:0003085	negative regulation of systemic arterial blood pressure
0.47	GO:0001836	release of cytochrome c from mitochondria

0.77	GO:0004784	superoxide dismutase activity
0.54	GO:0046872	metal ion binding
0.37	GO:0042802	identical protein binding
0.37	GO:0019825	oxygen binding
0.36	GO:0019899	enzyme binding
0.34	GO:0003677	DNA binding

0.45	GO:0043209	myelin sheath
0.45	GO:0005759	mitochondrial matrix
0.39	GO:0031966	mitochondrial membrane
0.39	GO:0019866	organelle inner membrane
0.36	GO:0009295	nucleoid
0.36	GO:0070062	extracellular exosome
0.34	GO:0043232	intracellular non-membrane-bounded organelle

0.77

EC:1.15.1.1

GO:0004784

sp|P04180|LCAT_HUMAN
Phosphatidylcholine-sterol acyltransferase
Search

LCAT

0.77	Phosphatidylcholine-sterol acyltransferase

0.65	GO:0034435	cholesterol esterification
0.64	GO:0090107	regulation of high-density lipoprotein particle assembly
0.63	GO:0034372	very-low-density lipoprotein particle remodeling
0.63	GO:0034375	high-density lipoprotein particle remodeling
0.62	GO:0043691	reverse cholesterol transport
0.61	GO:0008203	cholesterol metabolic process
0.60	GO:0042632	cholesterol homeostasis
0.60	GO:0046470	phosphatidylcholine metabolic process
0.54	GO:0042158	lipoprotein biosynthetic process
0.54	GO:0046474	glycerophospholipid biosynthetic process

0.74	GO:0008374	O-acyltransferase activity
0.64	GO:0034186	apolipoprotein A-I binding
0.38	GO:0015379	potassium:chloride symporter activity
0.37	GO:0008239	dipeptidyl-peptidase activity
0.37	GO:0016805	dipeptidase activity
0.36	GO:0008235	metalloexopeptidase activity
0.35	GO:0004623	phospholipase A2 activity

0.61	GO:0034364	high-density lipoprotein particle
0.38	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.74

EC:2.3.1

GO:0008374

sp|P04181|OAT_HUMAN
Ornithine aminotransferase, mitochondrial
Search

OAT

0.54	Ornithine aminotransferaseserine-threonine

0.56	GO:0034214	protein hexamerization
0.38	GO:0055129	L-proline biosynthetic process
0.34	GO:0007601	visual perception
0.34	GO:0006591	ornithine metabolic process

0.83	GO:0004587	ornithine-oxo-acid transaminase activity
0.67	GO:0030170	pyridoxal phosphate binding
0.43	GO:0042802	identical protein binding
0.34	GO:0003992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
0.33	GO:0008289	lipid binding
0.33	GO:0008453	alanine-glyoxylate transaminase activity

0.47	GO:0005654	nucleoplasm
0.45	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.83	EC:2.6.1.13	GO:0004587
0.34	KEGG:R02283	GO:0003992

sp|P04183|KITH_HUMAN
Thymidine kinase, cytosolic
Search

TK1

0.50	Thymidine kinase, cytosolic

0.76	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process
0.67	GO:0071897	DNA biosynthetic process
0.57	GO:0016310	phosphorylation
0.55	GO:0051289	protein homotetramerization
0.47	GO:0046104	thymidine metabolic process
0.35	GO:0009165	nucleotide biosynthetic process
0.35	GO:0060138	fetal process involved in parturition
0.35	GO:0043097	pyrimidine nucleoside salvage
0.34	GO:0014856	skeletal muscle cell proliferation
0.34	GO:0051414	response to cortisol

0.81	GO:0004797	thymidine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0042802	identical protein binding
0.45	GO:0008270	zinc ion binding

0.35

GO:0005829

cytosol

0.81

EC:2.7.1.21

GO:0004797

sp|P04196|HRG_HUMAN
Histidine-rich glycoprotein
Search

HRG

0.94	histidine-rich glycoprotein isoform X1

0.76	GO:0010593	negative regulation of lamellipodium assembly
0.76	GO:2000504	positive regulation of blood vessel remodeling
0.75	GO:2001027	negative regulation of endothelial cell chemotaxis
0.75	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway
0.74	GO:0033629	negative regulation of cell adhesion mediated by integrin
0.74	GO:0010951	negative regulation of endopeptidase activity
0.74	GO:0002839	positive regulation of immune response to tumor cell
0.72	GO:0051894	positive regulation of focal adhesion assembly
0.71	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
0.70	GO:0030193	regulation of blood coagulation

0.79	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.71	GO:0043395	heparan sulfate proteoglycan binding
0.71	GO:0019865	immunoglobulin binding
0.69	GO:0008201	heparin binding
0.60	GO:0005102	receptor binding
0.54	GO:0008270	zinc ion binding
0.54	GO:0020037	heme binding
0.53	GO:0004867	serine-type endopeptidase inhibitor activity
0.37	GO:0043565	sequence-specific DNA binding
0.34	GO:0016852	sirohydrochlorin cobaltochelatase activity

0.61	GO:0009986	cell surface
0.59	GO:0036019	endolysosome
0.57	GO:0005576	extracellular region
0.43	GO:0061474	phagolysosome membrane
0.42	GO:0031093	platelet alpha granule lumen
0.37	GO:0005634	nucleus
0.35	GO:0005886	plasma membrane
0.33	GO:0044427	chromosomal part
0.32	GO:0005700	polytene chromosome
0.32	GO:0005667	transcription factor complex

0.34

EC:4.99.1.3

GO:0016852

sp|P04198|MYCN_HUMAN
N-myc proto-oncogene protein
Search

MYCN

0.97	MYCN proto-oncogene, bHLH transcription factor

0.61	GO:0045607	regulation of inner ear auditory receptor cell differentiation
0.60	GO:0048712	negative regulation of astrocyte differentiation
0.59	GO:0001502	cartilage condensation
0.59	GO:0002053	positive regulation of mesenchymal cell proliferation
0.59	GO:2000378	negative regulation of reactive oxygen species metabolic process
0.58	GO:0042733	embryonic digit morphogenesis
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:0048704	embryonic skeletal system morphogenesis
0.57	GO:0048754	branching morphogenesis of an epithelial tube

0.66	GO:0046983	protein dimerization activity
0.61	GO:0003700	DNA binding transcription factor activity
0.56	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.54	GO:0019900	kinase binding
0.35	GO:0032403	protein complex binding
0.32	GO:0008270	zinc ion binding
0.32	GO:0004842	ubiquitin-protein transferase activity
0.32	GO:0003743	translation initiation factor activity
0.32	GO:0016779	nucleotidyltransferase activity
0.32	GO:0017025	TBP-class protein binding

0.61	GO:0005634	nucleus
0.49	GO:0070013	intracellular organelle lumen
0.45	GO:0043232	intracellular non-membrane-bounded organelle
0.44	GO:0044446	intracellular organelle part
0.32	GO:0042025	host cell nucleus

0.32	EC:2.7.7	GO:0016779
0.32	KEGG:R03876	GO:0004842

sp|P04201|MAS_HUMAN
Proto-oncogene Mas
Search

MAS1

0.93	Proto-oncogene Mas

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.59	GO:0070528	protein kinase C signaling
0.59	GO:1904385	cellular response to angiotensin
0.58	GO:0007250	activation of NF-kappaB-inducing kinase activity
0.55	GO:0050727	regulation of inflammatory response
0.43	GO:0060732	positive regulation of inositol phosphate biosynthetic process
0.43	GO:0034698	response to gonadotropin
0.42	GO:0014823	response to activity
0.42	GO:0021766	hippocampus development
0.42	GO:0045740	positive regulation of DNA replication

0.72	GO:0004930	G-protein coupled receptor activity
0.54	GO:0001653	peptide receptor activity
0.54	GO:0042277	peptide binding
0.41	GO:0042562	hormone binding
0.34	GO:0005515	protein binding
0.32	GO:0005509	calcium ion binding

0.44	GO:0005887	integral component of plasma membrane
0.40	GO:0009986	cell surface
0.38	GO:0005622	intracellular
0.33	GO:0043233	organelle lumen
0.32	GO:0043227	membrane-bounded organelle

sp|P04211|LV743_HUMAN
Immunoglobulin lambda variable 7-43
Search

0.50	Anti-quaternary epitope monoclonal antibody light chain (Fragment)

0.77	GO:0002377	immunoglobulin production
0.71	GO:0006955	immune response
0.53	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.53	GO:0038095	Fc-epsilon receptor signaling pathway
0.52	GO:0030449	regulation of complement activation
0.51	GO:0002449	lymphocyte mediated immunity
0.50	GO:0072376	protein activation cascade
0.50	GO:0050900	leukocyte migration
0.46	GO:0006898	receptor-mediated endocytosis
0.42	GO:0006508	proteolysis

0.61	GO:0003823	antigen binding
0.45	GO:0004252	serine-type endopeptidase activity
0.35	GO:0051082	unfolded protein binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.68	GO:0005615	extracellular space
0.41	GO:0005886	plasma membrane
0.40	GO:1903561	extracellular vesicle
0.38	GO:0071745	IgA immunoglobulin complex
0.38	GO:0071753	IgM immunoglobulin complex
0.30	GO:0016021	integral component of membrane

0.45

GO:0004252

sp|P04216|THY1_HUMAN
Thy-1 membrane glycoprotein
Search

THY1

0.96	Thy-1 cell surface antigen

0.79	GO:0030334	regulation of cell migration
0.72	GO:0007155	cell adhesion
0.68	GO:0046549	retinal cone cell development
0.67	GO:0050860	negative regulation of T cell receptor signaling pathway
0.67	GO:2000298	regulation of Rho-dependent protein serine/threonine kinase activity
0.66	GO:0034116	positive regulation of heterotypic cell-cell adhesion
0.65	GO:0051894	positive regulation of focal adhesion assembly
0.64	GO:0010977	negative regulation of neuron projection development
0.62	GO:0070570	regulation of neuron projection regeneration
0.62	GO:0001525	angiogenesis

0.84	GO:0005178	integrin binding
0.57	GO:0034235	GPI anchor binding
0.50	GO:0005096	GTPase activator activity
0.49	GO:0019901	protein kinase binding
0.35	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity

0.65	GO:0031362	anchored component of external side of plasma membrane
0.61	GO:0043209	myelin sheath
0.60	GO:0016324	apical plasma membrane
0.60	GO:0030425	dendrite
0.60	GO:0098857	membrane microdomain
0.54	GO:0005783	endoplasmic reticulum
0.49	GO:0030426	growth cone
0.43	GO:0032809	neuronal cell body membrane
0.43	GO:0030673	axolemma
0.38	GO:0005829	cytosol

0.35