Queries 2001 to 3000

GO:0036459

sp|O00488|ZN593_HUMAN
Zinc finger protein 593
Search

ZNF593

0.52	Zinc finger domain-containing protein (Fragment)

0.59	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
0.52	GO:0045944	positive regulation of transcription by RNA polymerase II
0.51	GO:0000055	ribosomal large subunit export from nucleus
0.47	GO:0009245	lipid A biosynthetic process
0.35	GO:0006351	transcription, DNA-templated
0.34	GO:0006434	seryl-tRNA aminoacylation

0.60	GO:0008270	zinc ion binding
0.54	GO:0000035	acyl binding
0.50	GO:0003676	nucleic acid binding
0.49	GO:0044620	ACP phosphopantetheine attachment site binding
0.49	GO:0043023	ribosomal large subunit binding
0.48	GO:0140104	molecular carrier activity
0.48	GO:0031177	phosphopantetheine binding
0.34	GO:0005515	protein binding
0.34	GO:0004828	serine-tRNA ligase activity
0.32	GO:0030554	adenyl nucleotide binding

0.51	GO:0005730	nucleolus
0.50	GO:0030687	preribosome, large subunit precursor
0.45	GO:0005829	cytosol
0.33	GO:0005840	ribosome

0.34

EC:6.1.1.11

GO:0004828

sp|O00499|BIN1_HUMAN
Myc box-dependent-interacting protein 1
Search

BIN1

0.81	Bridging integrator 1

0.83	GO:0030100	regulation of endocytosis
0.74	GO:0048711	positive regulation of astrocyte differentiation
0.74	GO:0060988	lipid tube assembly
0.71	GO:0051647	nucleus localization
0.71	GO:0071156	regulation of cell cycle arrest
0.68	GO:0042692	muscle cell differentiation
0.68	GO:0006997	nucleus organization
0.66	GO:0045664	regulation of neuron differentiation
0.66	GO:0043065	positive regulation of apoptotic process

0.78	GO:0048156	tau protein binding
0.65	GO:0051015	actin filament binding
0.65	GO:0070063	RNA polymerase binding
0.62	GO:0042802	identical protein binding

0.78	GO:0060987	lipid tube
0.67	GO:0030424	axon
0.64	GO:0005635	nuclear envelope
0.60	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O00501|CLD5_HUMAN
Claudin-5
Search

0.68

Claudin b

0.49	GO:0045216	cell-cell junction organization
0.42	GO:0051806	entry into cell of other organism involved in symbiotic interaction
0.42	GO:0044409	entry into host
0.42	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
0.41	GO:0019058	viral life cycle
0.40	GO:1901552	positive regulation of endothelial cell development
0.40	GO:0048856	anatomical structure development
0.40	GO:1903140	regulation of establishment of endothelial barrier
0.39	GO:0034329	cell junction assembly
0.39	GO:0045471	response to ethanol

0.62	GO:0005198	structural molecule activity
0.50	GO:0104005	hijacked molecular function
0.39	GO:0042802	identical protein binding
0.34	GO:0005254	chloride channel activity

0.81	GO:0005923	bicellular tight junction
0.55	GO:0005886	plasma membrane
0.40	GO:0043220	Schmidt-Lanterman incisure
0.40	GO:0033270	paranode region of axon
0.39	GO:0043227	membrane-bounded organelle
0.38	GO:0043229	intracellular organelle
0.38	GO:0044448	cell cortex part
0.37	GO:0043230	extracellular organelle
0.36	GO:0005615	extracellular space
0.35	GO:0043228	non-membrane-bounded organelle

sp|O00505|IMA4_HUMAN
Importin subunit alpha-4
Search

KPNA3

0.60	Importin subunit alpha

0.80	GO:0006606	protein import into nucleus
0.41	GO:0042542	response to hydrogen peroxide
0.35	GO:0016125	sterol metabolic process
0.34	GO:1902594	multi-organism nuclear import
0.34	GO:0075733	intracellular transport of virus
0.33	GO:0044068	modulation by symbiont of host cellular process
0.33	GO:0006461	protein complex assembly
0.33	GO:0019048	modulation by virus of host morphology or physiology
0.33	GO:0051806	entry into cell of other organism involved in symbiotic interaction
0.33	GO:0044409	entry into host

0.83	GO:0061608	nuclear import signal receptor activity
0.66	GO:0008565	protein transporter activity
0.53	GO:0008022	protein C-terminus binding
0.48	GO:0008139	nuclear localization sequence binding
0.36	GO:0047750	cholestenol delta-isomerase activity

0.61	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.44	GO:0012505	endomembrane system
0.42	GO:0031974	membrane-enclosed lumen
0.42	GO:0031967	organelle envelope
0.39	GO:0043234	protein complex
0.37	GO:0031090	organelle membrane
0.33	GO:0044217	other organism part
0.33	GO:0018995	host
0.30	GO:0031224	intrinsic component of membrane

0.36

EC:5.3.3.5

GO:0047750

sp|O00506|STK25_HUMAN
Serine/threonine-protein kinase 25
Search

STK25

0.75	Serine/threonine-protein kinase 25

0.63	GO:0006468	protein phosphorylation
0.58	GO:0036481	intrinsic apoptotic signaling pathway in response to hydrogen peroxide
0.57	GO:0090168	Golgi reassembly
0.57	GO:0051683	establishment of Golgi localization
0.55	GO:0050772	positive regulation of axonogenesis
0.53	GO:0032874	positive regulation of stress-activated MAPK cascade
0.52	GO:0007163	establishment or maintenance of cell polarity
0.47	GO:0000185	activation of MAPKKK activity
0.45	GO:0031098	stress-activated protein kinase signaling cascade
0.45	GO:0009653	anatomical structure morphogenesis

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0042803	protein homodimerization activity
0.45	GO:0005057	signal transducer activity, downstream of receptor
0.35	GO:0045296	cadherin binding
0.34	GO:0046872	metal ion binding

0.48	GO:0005794	Golgi apparatus
0.37	GO:0098588	bounding membrane of organelle
0.36	GO:0031984	organelle subcompartment
0.36	GO:0070062	extracellular exosome
0.34	GO:0005730	nucleolus
0.34	GO:0005829	cytosol

sp|O00507|USP9Y_HUMAN
Probable ubiquitin carboxyl-terminal hydrolase FAF-Y
Search

USP9X

0.96	Ubiquitin specific peptidase 9 Y-linked

0.76	GO:0016579	protein deubiquitination
0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.48	GO:0016477	cell migration
0.48	GO:0048675	axon extension
0.48	GO:0030509	BMP signaling pathway
0.48	GO:0007179	transforming growth factor beta receptor signaling pathway
0.38	GO:0021698	cerebellar cortex structural organization
0.37	GO:0021766	hippocampus development
0.37	GO:0001701	in utero embryonic development
0.36	GO:0009791	post-embryonic development

0.77	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.50	GO:0070410	co-SMAD binding
0.34	GO:0004197	cysteine-type endopeptidase activity

0.48	GO:0030426	growth cone
0.37	GO:0005737	cytoplasm
0.37	GO:0045177	apical part of cell
0.30	GO:0016021	integral component of membrane

0.77

GO:0036459

sp|O00512|BCL9_HUMAN
B-cell CLL/lymphoma 9 protein
Search

BCL9

0.97	B-cell lymphoma 9

0.83	GO:0060070	canonical Wnt signaling pathway
0.63	GO:0014908	myotube differentiation involved in skeletal muscle regeneration
0.60	GO:0035019	somatic stem cell population maintenance
0.59	GO:0035914	skeletal muscle cell differentiation
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.53	GO:1902680	positive regulation of RNA biosynthetic process
0.52	GO:0010628	positive regulation of gene expression
0.44	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.38	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
0.38	GO:1904837	beta-catenin-TCF complex assembly

0.83	GO:0008013	beta-catenin binding
0.78	GO:0003713	transcription coactivator activity
0.32	GO:0046872	metal ion binding

0.64	GO:1990907	beta-catenin-TCF complex
0.59	GO:0005801	cis-Golgi network
0.52	GO:0005794	Golgi apparatus
0.35	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O00515|LAD1_HUMAN
Ladinin-1
Search

LAD1

0.95

Ladinin-1

0.41

GO:0006937

regulation of muscle contraction

0.64	GO:0045296	cadherin binding
0.58	GO:0005198	structural molecule activity
0.32	GO:0008270	zinc ion binding
0.32	GO:0003677	DNA binding

0.68	GO:0005604	basement membrane
0.67	GO:0070062	extracellular exosome
0.62	GO:0015629	actin cytoskeleton
0.41	GO:0036379	myofilament
0.41	GO:0030017	sarcomere
0.38	GO:0044430	cytoskeletal part
0.36	GO:0043234	protein complex
0.32	GO:0005634	nucleus

sp|O00519|FAAH1_HUMAN
Fatty-acid amide hydrolase 1
Search

FAAH

0.82	Fatty acid amide hydrolase

0.55	GO:0009062	fatty acid catabolic process
0.37	GO:0019369	arachidonic acid metabolic process
0.36	GO:0097756	negative regulation of blood vessel diameter

0.84	GO:0017064	fatty acid amide hydrolase activity
0.73	GO:0004040	amidase activity
0.58	GO:0047372	acylglycerol lipase activity
0.44	GO:0103073	anandamide amidohydrolase activity
0.44	GO:0102077	oleamide hydrolase activity
0.35	GO:0005515	protein binding
0.35	GO:0005543	phospholipid binding

0.39	GO:0005789	endoplasmic reticulum membrane
0.38	GO:0000139	Golgi membrane
0.35	GO:0005856	cytoskeleton
0.30	GO:0031224	intrinsic component of membrane

0.73

EC:3.5.1.4

GO:0004040

sp|O00522|KRIT1_HUMAN
Krev interaction trapped protein 1
Search

KRIT1

0.92	LOW QUALITY PROTEIN: krev interaction trapped protein 1

0.49	GO:2000352	negative regulation of endothelial cell apoptotic process
0.48	GO:0001937	negative regulation of endothelial cell proliferation
0.48	GO:0016525	negative regulation of angiogenesis
0.48	GO:0010596	negative regulation of endothelial cell migration
0.46	GO:2000114	regulation of establishment of cell polarity
0.45	GO:0032092	positive regulation of protein binding
0.44	GO:0001525	angiogenesis
0.42	GO:0045454	cell redox homeostasis
0.38	GO:0072554	blood vessel lumenization
0.38	GO:0045602	negative regulation of endothelial cell differentiation

0.48	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.44	GO:0032403	protein complex binding
0.44	GO:0008017	microtubule binding
0.39	GO:0030695	GTPase regulator activity

0.69	GO:0005856	cytoskeleton
0.45	GO:0030054	cell junction
0.45	GO:0099512	supramolecular fiber
0.40	GO:0044446	intracellular organelle part
0.39	GO:0005886	plasma membrane
0.38	GO:0043234	protein complex
0.37	GO:0005615	extracellular space
0.36	GO:0005737	cytoplasm

sp|O00526|UPK2_HUMAN
Uroplakin-2
Search

UPK2

0.97	Uroplakin-2

0.68	GO:0030855	epithelial cell differentiation
0.36	GO:0007275	multicellular organism development
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:2001141	regulation of RNA biosynthetic process
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0010468	regulation of gene expression

0.37	GO:0005515	protein binding
0.36	GO:0043565	sequence-specific DNA binding
0.36	GO:0003700	DNA binding transcription factor activity

0.55	GO:0016324	apical plasma membrane
0.41	GO:0070062	extracellular exosome
0.38	GO:0005887	integral component of plasma membrane
0.36	GO:0005783	endoplasmic reticulum
0.36	GO:0005634	nucleus

sp|O00533|NCHL1_HUMAN
Neural cell adhesion molecule L1-like protein
Search

CHL1

0.96	Cell adhesion molecule L1 like

0.59	GO:0035640	exploration behavior
0.57	GO:0008344	adult locomotory behavior
0.57	GO:0043524	negative regulation of neuron apoptotic process
0.57	GO:0001764	neuron migration
0.56	GO:0050890	cognition
0.56	GO:0007411	axon guidance
0.41	GO:0031103	axon regeneration
0.38	GO:0007155	cell adhesion
0.34	GO:0007165	signal transduction

0.57

GO:0002020

protease binding

0.56	GO:0030425	dendrite
0.55	GO:0045177	apical part of cell
0.38	GO:0070062	extracellular exosome
0.37	GO:0005578	proteinaceous extracellular matrix
0.34	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O00534|VMA5A_HUMAN
von Willebrand factor A domain-containing protein 5A
Search

VWA5A

0.87	von Willebrand factor A domain-containing protein 5A

0.49

GO:0060923

cardiac muscle cell fate commitment

0.66	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O00541|PESC_HUMAN
Pescadillo homolog
Search

PES1

0.76	Pescadillo ribosomal biogenesis factor 1

0.74	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.73	GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.56	GO:0007000	nucleolus organization
0.53	GO:0008283	cell proliferation
0.52	GO:0051726	regulation of cell cycle
0.49	GO:0033365	protein localization to organelle
0.44	GO:0031017	exocrine pancreas development
0.43	GO:0048709	oligodendrocyte differentiation
0.34	GO:0009247	glycolipid biosynthetic process

0.65	GO:0043021	ribonucleoprotein complex binding
0.40	GO:0003723	RNA binding
0.36	GO:0050694	galactose 3-O-sulfotransferase activity
0.34	GO:0005515	protein binding

0.73	GO:0005730	nucleolus
0.72	GO:0030687	preribosome, large subunit precursor
0.69	GO:0005654	nucleoplasm
0.56	GO:0030686	90S preribosome
0.54	GO:0005694	chromosome
0.48	GO:0005829	cytosol
0.45	GO:0043234	protein complex
0.34	GO:0005794	Golgi apparatus
0.30	GO:0031224	intrinsic component of membrane

0.36

GO:0050694

sp|O00548|DLL1_HUMAN
Delta-like protein 1
Search

0.80	Delta-like protein D

0.78	GO:0007219	Notch signaling pathway
0.69	GO:0007275	multicellular organism development
0.60	GO:0032693	negative regulation of interleukin-10 production
0.60	GO:0060847	endothelial cell fate specification
0.60	GO:0046331	lateral inhibition
0.60	GO:0048633	positive regulation of skeletal muscle tissue growth
0.60	GO:0002085	inhibition of neuroepithelial cell differentiation
0.59	GO:0097150	neuronal stem cell population maintenance
0.59	GO:0014807	regulation of somitogenesis
0.59	GO:0034351	negative regulation of glial cell apoptotic process

0.70	GO:0005509	calcium ion binding
0.61	GO:0030957	Tat protein binding
0.59	GO:0005112	Notch binding
0.57	GO:0097110	scaffold protein binding
0.35	GO:0030165	PDZ domain binding

0.54	GO:0016324	apical plasma membrane
0.54	GO:0098857	membrane microdomain
0.53	GO:0005912	adherens junction
0.50	GO:0031410	cytoplasmic vesicle
0.35	GO:0048471	perinuclear region of cytoplasm
0.34	GO:0005887	integral component of plasma membrane
0.34	GO:0005576	extracellular region
0.34	GO:0005938	cell cortex
0.31	GO:0005634	nucleus

sp|O00555|CAC1A_HUMAN
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Search

CACNA1A

0.84	Voltage-dependent N-type calcium channel subunit alpha

0.77	GO:0034765	regulation of ion transmembrane transport
0.76	GO:0070588	calcium ion transmembrane transport
0.54	GO:0021750	vestibular nucleus development
0.54	GO:0051899	membrane depolarization
0.54	GO:0050883	musculoskeletal movement, spinal reflex action
0.54	GO:0021679	cerebellar molecular layer development
0.54	GO:0030644	cellular chloride ion homeostasis
0.54	GO:0021590	cerebellum maturation
0.54	GO:0014056	regulation of acetylcholine secretion, neurotransmission
0.53	GO:0014051	gamma-aminobutyric acid secretion

0.81	GO:0005245	voltage-gated calcium channel activity
0.40	GO:0005509	calcium ion binding
0.39	GO:0019905	syntaxin binding
0.37	GO:0008022	protein C-terminus binding
0.35	GO:0005516	calmodulin binding

0.80	GO:0005891	voltage-gated calcium channel complex
0.50	GO:0043025	neuronal cell body
0.49	GO:0030425	dendrite
0.48	GO:0098793	presynapse
0.35	GO:0005634	nucleus
0.33	GO:0005737	cytoplasm
0.33	GO:0043234	protein complex

sp|O00559|RCAS1_HUMAN
Receptor-binding cancer antigen expressed on SiSo cells
Search

EBAG9

0.97	Receptor-binding cancer antigen expressed on SiSo cells

0.76	GO:0006915	apoptotic process
0.35	GO:0001558	regulation of cell growth

0.36	GO:0016505	peptidase activator activity involved in apoptotic process
0.33	GO:0005515	protein binding
0.32	GO:0003723	RNA binding

0.72	GO:0000139	Golgi membrane
0.38	GO:0030141	secretory granule
0.30	GO:0044425	membrane part

sp|O00560|SDCB1_HUMAN
Syntenin-1
Search

SDCBP

0.93	Putative pdz domain containing protein found in a variety of eumetazoan signaling molecules

0.78	GO:0007268	chemical synaptic transmission
0.74	GO:0030036	actin cytoskeleton organization
0.63	GO:0035556	intracellular signal transduction
0.52	GO:0030307	positive regulation of cell growth
0.51	GO:0030335	positive regulation of cell migration
0.50	GO:0008284	positive regulation of cell proliferation
0.43	GO:0055113	epiboly involved in gastrulation with mouth forming second
0.42	GO:0042246	tissue regeneration
0.42	GO:0007416	synapse assembly
0.41	GO:0001666	response to hypoxia

0.56	GO:0005137	interleukin-5 receptor binding
0.48	GO:0045545	syndecan binding
0.43	GO:1902936	phosphatidylinositol bisphosphate binding
0.38	GO:0050839	cell adhesion molecule binding
0.38	GO:0005109	frizzled binding
0.38	GO:0042043	neurexin family protein binding
0.38	GO:0046875	ephrin receptor binding
0.38	GO:0047485	protein N-terminus binding
0.38	GO:0008022	protein C-terminus binding
0.37	GO:0019838	growth factor binding

0.57	GO:0005895	interleukin-5 receptor complex
0.51	GO:0031965	nuclear membrane
0.47	GO:0005654	nucleoplasm
0.47	GO:0005829	cytosol
0.38	GO:0042470	melanosome
0.37	GO:0005925	focal adhesion
0.37	GO:0070062	extracellular exosome
0.37	GO:0098857	membrane microdomain
0.37	GO:0072562	blood microparticle
0.36	GO:0005789	endoplasmic reticulum membrane

sp|O00562|PITM1_HUMAN
Membrane-associated phosphatidylinositol transfer protein 1
Search

PITPNM1

0.94	Membrane-associated phosphatidylinositol transfer protein 1

0.77	GO:0015914	phospholipid transport
0.41	GO:0048015	phosphatidylinositol-mediated signaling
0.37	GO:0015031	protein transport
0.36	GO:0007420	brain development
0.36	GO:0007602	phototransduction
0.36	GO:0006661	phosphatidylinositol biosynthetic process

0.78	GO:0005548	phospholipid transporter activity
0.61	GO:0030971	receptor tyrosine kinase binding
0.60	GO:0031210	phosphatidylcholine binding
0.60	GO:0070300	phosphatidic acid binding
0.53	GO:0035091	phosphatidylinositol binding
0.53	GO:0046872	metal ion binding

0.55	GO:0036464	cytoplasmic ribonucleoprotein granule
0.53	GO:0005815	microtubule organizing center
0.50	GO:0005829	cytosol
0.42	GO:0044297	cell body
0.41	GO:0032154	cleavage furrow
0.40	GO:0030496	midbody
0.40	GO:0005811	lipid droplet
0.40	GO:0032580	Golgi cisterna membrane
0.38	GO:0005789	endoplasmic reticulum membrane

sp|O00566|MPP10_HUMAN
U3 small nucleolar ribonucleoprotein protein MPP10
Search

MPHOSPH10

0.74	U3 small nucleolar ribonucleoprotein protein MPP10

0.67	GO:0006364	rRNA processing
0.56	GO:0010923	negative regulation of phosphatase activity
0.46	GO:0042274	ribosomal small subunit biogenesis
0.35	GO:0000375	RNA splicing, via transesterification reactions

0.35	GO:0003723	RNA binding
0.34	GO:0005515	protein binding

0.83	GO:0034457	Mpp10 complex
0.78	GO:0005732	small nucleolar ribonucleoprotein complex
0.60	GO:0019013	viral nucleocapsid
0.48	GO:0032040	small-subunit processome
0.36	GO:0005694	chromosome
0.35	GO:0005654	nucleoplasm

sp|O00567|NOP56_HUMAN
Nucleolar protein 56
Search

NOP56

0.90	NOP56 ribonucleoprotein homolog

0.57	GO:0007507	heart development
0.51	GO:0000154	rRNA modification

0.73	GO:1990226	histone methyltransferase binding
0.70	GO:0030515	snoRNA binding
0.66	GO:0045296	cadherin binding

0.73	GO:0070761	pre-snoRNP complex
0.68	GO:0005732	small nucleolar ribonucleoprotein complex
0.67	GO:0001650	fibrillar center
0.55	GO:0032040	small-subunit processome
0.49	GO:0019013	viral nucleocapsid
0.30	GO:0016020	membrane

sp|O00570|SOX1_HUMAN
Transcription factor SOX-1
Search

SOX1

0.84	Transcription factor SOX-1

0.65	GO:0007399	nervous system development
0.53	GO:2001141	regulation of RNA biosynthetic process
0.53	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.52	GO:0060573	cell fate specification involved in pattern specification
0.52	GO:0010468	regulation of gene expression
0.52	GO:0002089	lens morphogenesis in camera-type eye
0.50	GO:1990830	cellular response to leukemia inhibitory factor
0.50	GO:0009953	dorsal/ventral pattern formation
0.49	GO:0060322	head development
0.48	GO:0016477	cell migration

0.54	GO:0003677	DNA binding
0.49	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.48	GO:0001067	regulatory region nucleic acid binding
0.35	GO:0005515	protein binding
0.35	GO:0035198	miRNA binding

0.61	GO:0005634	nucleus
0.34	GO:0005667	transcription factor complex
0.33	GO:0005829	cytosol
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

sp|O00571|DDX3X_HUMAN
ATP-dependent RNA helicase DDX3X
Search

DDX3X

0.91	DEAD-box helicase 3, X-linked

0.48	GO:0010501	RNA secondary structure unwinding
0.48	GO:1903608	protein localization to cytoplasmic stress granule
0.48	GO:0071243	cellular response to arsenic-containing substance
0.47	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
0.47	GO:0045070	positive regulation of viral genome replication
0.47	GO:0034063	stress granule assembly
0.47	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
0.46	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway
0.46	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.46	GO:0090263	positive regulation of canonical Wnt signaling pathway

0.67	GO:0004386	helicase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.50	GO:0043273	CTPase activity
0.47	GO:0008190	eukaryotic initiation factor 4E binding
0.47	GO:0043024	ribosomal small subunit binding
0.46	GO:0043539	protein serine/threonine kinase activator activity

0.47	GO:0036464	cytoplasmic ribonucleoprotein granule
0.45	GO:0022627	cytosolic small ribosomal subunit
0.44	GO:0005852	eukaryotic translation initiation factor 3 complex
0.42	GO:0005634	nucleus
0.40	GO:0070013	intracellular organelle lumen
0.38	GO:0070062	extracellular exosome
0.37	GO:0005741	mitochondrial outer membrane
0.37	GO:0101002	ficolin-1-rich granule
0.36	GO:0031983	vesicle lumen
0.35	GO:0044433	cytoplasmic vesicle part

sp|O00574|CXCR6_HUMAN
C-X-C chemokine receptor type 6
Search

CXCR6

0.97	G protein-coupled receptor TYMSTR

0.79	GO:0070098	chemokine-mediated signaling pathway
0.71	GO:0006954	inflammatory response
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.67	GO:0006935	chemotaxis
0.45	GO:0006955	immune response
0.43	GO:0046877	regulation of saliva secretion
0.42	GO:0019233	sensory perception of pain
0.41	GO:0002252	immune effector process
0.41	GO:0009615	response to virus
0.41	GO:0098542	defense response to other organism

0.80	GO:0004950	chemokine receptor activity
0.75	GO:0015026	coreceptor activity
0.62	GO:0019956	chemokine binding
0.51	GO:0038048	dynorphin receptor activity
0.39	GO:0005044	scavenger receptor activity
0.38	GO:0042923	neuropeptide binding
0.35	GO:0048020	CCR chemokine receptor binding
0.34	GO:0051916	granulocyte colony-stimulating factor binding
0.32	GO:0004995	tachykinin receptor activity

0.41	GO:0005886	plasma membrane
0.39	GO:0005829	cytosol
0.38	GO:0120025	plasma membrane bounded cell projection
0.38	GO:0005634	nucleus
0.36	GO:0097223	sperm part
0.36	GO:0097458	neuron part
0.36	GO:0009986	cell surface
0.36	GO:0044463	cell projection part
0.35	GO:0044297	cell body
0.34	GO:0098552	side of membrane

sp|O00584|RNT2_HUMAN
Ribonuclease T2
Search

RNASET2

0.58	PolyU-preferential ribonuclease CL1

0.70	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.41	GO:0006401	RNA catabolic process
0.37	GO:0043312	neutrophil degranulation
0.33	GO:0016072	rRNA metabolic process

0.82	GO:0033897	ribonuclease T2 activity
0.59	GO:0003723	RNA binding

0.45	GO:0005788	endoplasmic reticulum lumen
0.44	GO:0005764	lysosome
0.43	GO:0005615	extracellular space
0.41	GO:0005775	vacuolar lumen
0.38	GO:1903561	extracellular vesicle
0.37	GO:0034774	secretory granule lumen
0.33	GO:0005618	cell wall
0.30	GO:0031224	intrinsic component of membrane

0.82

EC:3.1.27.1

GO:0033897

sp|O00585|CCL21_HUMAN
C-C motif chemokine 21
Search

CCL21

0.97	C-C motif chemokine ligand 21

0.82	GO:0060326	cell chemotaxis
0.80	GO:2000527	regulation of myeloid dendritic cell chemotaxis
0.79	GO:0035759	mesangial cell-matrix adhesion
0.77	GO:2000669	negative regulation of dendritic cell apoptotic process
0.77	GO:0001768	establishment of T cell polarity
0.77	GO:1903237	negative regulation of leukocyte tethering or rolling
0.76	GO:2000510	positive regulation of dendritic cell chemotaxis
0.75	GO:0031274	positive regulation of pseudopodium assembly
0.74	GO:0034695	response to prostaglandin E
0.74	GO:0033630	positive regulation of cell adhesion mediated by integrin

0.87	GO:0031732	CCR7 chemokine receptor binding
0.84	GO:0008009	chemokine activity
0.35	GO:0031727	CCR2 chemokine receptor binding
0.35	GO:0031737	CX3C chemokine receptor binding
0.35	GO:0016004	phospholipase activator activity
0.34	GO:0005178	integrin binding
0.33	GO:0004672	protein kinase activity

0.66	GO:0005576	extracellular region
0.38	GO:0009897	external side of plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O00587|MFNG_HUMAN
Beta-1,3-N-acetylglucosaminyltransferase manic fringe
Search

MFNG

0.85	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

0.67	GO:0007389	pattern specification process
0.65	GO:0002315	marginal zone B cell differentiation
0.64	GO:0036066	protein O-linked fucosylation
0.61	GO:0045747	positive regulation of Notch signaling pathway
0.61	GO:0032092	positive regulation of protein binding
0.48	GO:1902367	negative regulation of Notch signaling pathway involved in somitogenesis
0.46	GO:0051446	positive regulation of meiotic cell cycle
0.46	GO:0001541	ovarian follicle development
0.45	GO:0061053	somite development
0.45	GO:0030217	T cell differentiation

0.76	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
0.47	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding
0.32	GO:0016491	oxidoreductase activity

0.69	GO:0030173	integral component of Golgi membrane
0.36	GO:0044421	extracellular region part
0.34	GO:0031982	vesicle

0.76

EC:2.4.1.222

GO:0033829

sp|O00590|ACKR2_HUMAN
Atypical chemokine receptor 2
Search

ACKR2

0.96	C-C motif chemokine receptor 4

0.83	GO:0070098	chemokine-mediated signaling pathway
0.77	GO:0006954	inflammatory response
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.70	GO:0006935	chemotaxis
0.61	GO:0006898	receptor-mediated endocytosis
0.58	GO:0006955	immune response
0.46	GO:0090026	positive regulation of monocyte chemotaxis
0.43	GO:0002520	immune system development
0.42	GO:0030154	cell differentiation
0.42	GO:0046629	gamma-delta T cell activation

0.84	GO:0004950	chemokine receptor activity
0.75	GO:0019957	C-C chemokine binding
0.68	GO:0005044	scavenger receptor activity
0.37	GO:0019960	C-X3-C chemokine binding
0.33	GO:0048020	CCR chemokine receptor binding
0.33	GO:0004966	galanin receptor activity
0.32	GO:0008270	zinc ion binding

0.57	GO:0005887	integral component of plasma membrane
0.56	GO:0005884	actin filament
0.56	GO:0031965	nuclear membrane
0.51	GO:0005654	nucleoplasm
0.50	GO:0005829	cytosol
0.43	GO:0009986	cell surface
0.39	GO:0098552	side of membrane
0.39	GO:0055037	recycling endosome
0.39	GO:0005769	early endosome
0.36	GO:0043025	neuronal cell body

sp|O00591|GBRP_HUMAN
Gamma-aminobutyric acid receptor subunit pi
Search

GABRP

0.97	Gamma-aminobutyric acid type A receptor pi subunit

0.59	GO:0007165	signal transduction
0.59	GO:0034220	ion transmembrane transport
0.39	GO:0006821	chloride transport

0.75	GO:0004890	GABA-A receptor activity
0.73	GO:0005230	extracellular ligand-gated ion channel activity
0.39	GO:0005254	chloride channel activity
0.34	GO:0005509	calcium ion binding

0.54	GO:0005886	plasma membrane
0.50	GO:1902711	GABA-A receptor complex
0.40	GO:0034707	chloride channel complex
0.39	GO:0098794	postsynapse
0.38	GO:0030054	cell junction

sp|O00592|PODXL_HUMAN
Podocalyxin
Search

PODXL

0.96	Podocalyxin like

0.76	GO:0016477	cell migration
0.75	GO:0022407	regulation of cell-cell adhesion
0.64	GO:0007162	negative regulation of cell adhesion
0.56	GO:0007155	cell adhesion
0.54	GO:0033630	positive regulation of cell adhesion mediated by integrin
0.50	GO:0030335	positive regulation of cell migration
0.48	GO:0032534	regulation of microvillus assembly
0.45	GO:0032835	glomerulus development
0.44	GO:0061318	renal filtration cell differentiation
0.44	GO:0035850	epithelial cell differentiation involved in kidney development

0.37	GO:0005515	protein binding
0.32	GO:0004668	protein-arginine deiminase activity
0.32	GO:0003676	nucleic acid binding
0.32	GO:0005509	calcium ion binding
0.31	GO:0005198	structural molecule activity

0.63	GO:0016324	apical plasma membrane
0.55	GO:0042995	cell projection
0.50	GO:0031252	cell leading edge
0.48	GO:0070062	extracellular exosome
0.46	GO:0005815	microtubule organizing center
0.45	GO:0036057	slit diaphragm
0.45	GO:0005730	nucleolus
0.43	GO:0098857	membrane microdomain
0.38	GO:0005737	cytoplasm
0.36	GO:0005887	integral component of plasma membrane

0.32

EC:3.5.3.15

GO:0004668

sp|O00602|FCN1_HUMAN
Ficolin-1
Search

FCN2

0.87

Ficolin B

0.75	GO:0043654	recognition of apoptotic cell
0.70	GO:0001867	complement activation, lectin pathway
0.68	GO:0002752	cell surface pattern recognition receptor signaling pathway
0.67	GO:0046597	negative regulation of viral entry into host cell
0.65	GO:2000484	positive regulation of interleukin-8 secretion
0.63	GO:0034394	protein localization to cell surface
0.55	GO:0008228	opsonization
0.54	GO:0007186	G-protein coupled receptor signaling pathway
0.52	GO:0050830	defense response to Gram-positive bacterium
0.51	GO:0050829	defense response to Gram-negative bacterium

0.75	GO:0033691	sialic acid binding
0.63	GO:0008329	signaling pattern recognition receptor activity
0.58	GO:0001664	G-protein coupled receptor binding
0.58	GO:0030246	carbohydrate binding
0.56	GO:0003823	antigen binding
0.53	GO:0043394	proteoglycan binding
0.53	GO:0048306	calcium-dependent protein binding
0.49	GO:0001871	pattern binding
0.44	GO:0046872	metal ion binding
0.42	GO:0004252	serine-type endopeptidase activity

0.66	GO:0031232	extrinsic component of external side of plasma membrane
0.62	GO:0005581	collagen trimer
0.53	GO:0005576	extracellular region
0.45	GO:1904813	ficolin-1-rich granule lumen
0.44	GO:0034774	secretory granule lumen
0.30	GO:0016021	integral component of membrane

0.42

GO:0004252

sp|O00622|CYR61_HUMAN
Protein CYR61
Search

CYR61

0.97	Cysteine rich angiogenic inducer 61

0.77	GO:0001558	regulation of cell growth
0.64	GO:0002041	intussusceptive angiogenesis
0.63	GO:2000304	positive regulation of ceramide biosynthetic process
0.63	GO:0003278	apoptotic process involved in heart morphogenesis
0.62	GO:0060591	chondroblast differentiation
0.61	GO:0033690	positive regulation of osteoblast proliferation
0.61	GO:0060413	atrial septum morphogenesis
0.60	GO:0003181	atrioventricular valve morphogenesis
0.60	GO:0090505	epiboly involved in wound healing
0.60	GO:0010518	positive regulation of phospholipase activity

0.82	GO:0005520	insulin-like growth factor binding
0.59	GO:0005178	integrin binding
0.58	GO:0050840	extracellular matrix binding
0.47	GO:0008201	heparin binding
0.32	GO:1901265	nucleoside phosphate binding
0.32	GO:0036094	small molecule binding

0.65	GO:0005576	extracellular region
0.35	GO:0005788	endoplasmic reticulum lumen
0.30	GO:0016021	integral component of membrane

sp|O00623|PEX12_HUMAN
Peroxisome assembly protein 12
Search

PEX12

0.88	Peroxisome assembly protein 12

0.80	GO:0072662	protein localization to peroxisome
0.80	GO:0043574	peroxisomal transport
0.72	GO:0072594	establishment of protein localization to organelle
0.70	GO:0006605	protein targeting
0.55	GO:0017038	protein import
0.54	GO:0065002	intracellular protein transmembrane transport
0.49	GO:0006513	protein monoubiquitination
0.32	GO:0016310	phosphorylation

0.82	GO:0008022	protein C-terminus binding
0.62	GO:0008270	zinc ion binding
0.45	GO:0004842	ubiquitin-protein transferase activity
0.32	GO:0016301	kinase activity

0.79	GO:0005779	integral component of peroxisomal membrane
0.50	GO:1990429	peroxisomal importomer complex

0.45

GO:0004842

sp|O00624|NPT3_HUMAN
Sodium-dependent phosphate transport protein 3
Search

0.97	Sodium-dependent phosphate transport protein 3

0.55	GO:0055085	transmembrane transport
0.48	GO:0006820	anion transport
0.46	GO:0046415	urate metabolic process
0.46	GO:0006814	sodium ion transport
0.44	GO:1901998	toxin transport
0.42	GO:0071702	organic substance transport
0.41	GO:0015893	drug transport
0.40	GO:0071705	nitrogen compound transport
0.33	GO:0042137	sequestering of neurotransmitter
0.33	GO:0006796	phosphate-containing compound metabolic process

0.53	GO:0005436	sodium:phosphate symporter activity
0.47	GO:0015143	urate transmembrane transporter activity
0.44	GO:0019534	toxin transmembrane transporter activity
0.43	GO:0008308	voltage-gated anion channel activity
0.43	GO:0015136	sialic acid transmembrane transporter activity
0.42	GO:0015562	efflux transmembrane transporter activity
0.41	GO:0015238	drug transmembrane transporter activity
0.33	GO:0008068	extracellularly glutamate-gated chloride channel activity
0.33	GO:0005351	sugar:proton symporter activity
0.33	GO:0015321	sodium-dependent phosphate transmembrane transporter activity

0.47	GO:0005887	integral component of plasma membrane
0.46	GO:0016324	apical plasma membrane
0.43	GO:0048471	perinuclear region of cytoplasm
0.42	GO:0005765	lysosomal membrane
0.41	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0031410	cytoplasmic vesicle
0.38	GO:0005829	cytosol
0.36	GO:0098793	presynapse
0.36	GO:0031526	brush border membrane
0.36	GO:0012506	vesicle membrane

sp|O00625|PIR_HUMAN
Pirin
Search

PIR

0.50	Pirin (Iron-binding nuclear protein)

0.85	GO:1903131	mononuclear cell differentiation
0.81	GO:0002573	myeloid leukocyte differentiation
0.55	GO:2001141	regulation of RNA biosynthetic process
0.52	GO:0055114	oxidation-reduction process
0.40	GO:0007586	digestion
0.39	GO:0006351	transcription, DNA-templated
0.38	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.38	GO:0010468	regulation of gene expression
0.36	GO:1902358	sulfate transmembrane transport
0.35	GO:0006898	receptor-mediated endocytosis

0.85	GO:0008127	quercetin 2,3-dioxygenase activity
0.73	GO:0003712	transcription cofactor activity
0.52	GO:0046872	metal ion binding
0.37	GO:0005515	protein binding
0.36	GO:0005044	scavenger receptor activity
0.36	GO:0015116	sulfate transmembrane transporter activity
0.35	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.34	GO:0030545	receptor regulator activity
0.34	GO:0003723	RNA binding

0.66	GO:0005829	cytosol
0.59	GO:0005634	nucleus
0.37	GO:0031974	membrane-enclosed lumen
0.35	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.85	EC:1.13.11.24	GO:0008127
0.85	KEGG:R02156	GO:0008127

sp|O00626|CCL22_HUMAN
C-C motif chemokine 22
Search

CCL22

0.64	C-C motif chemokine

0.82	GO:0060326	cell chemotaxis
0.75	GO:0006954	inflammatory response
0.74	GO:0006955	immune response
0.71	GO:0010469	regulation of receptor activity
0.58	GO:0071674	mononuclear cell migration
0.57	GO:0097529	myeloid leukocyte migration
0.56	GO:0071347	cellular response to interleukin-1
0.55	GO:0071356	cellular response to tumor necrosis factor
0.55	GO:0072676	lymphocyte migration
0.54	GO:0019221	cytokine-mediated signaling pathway

0.84	GO:0008009	chemokine activity
0.57	GO:0048020	CCR chemokine receptor binding
0.37	GO:0016004	phospholipase activator activity
0.35	GO:0004672	protein kinase activity
0.34	GO:0008201	heparin binding
0.33	GO:0046983	protein dimerization activity

0.73	GO:0005615	extracellular space
0.33	GO:0005622	intracellular
0.30	GO:0044425	membrane part

sp|O00628|PEX7_HUMAN
Peroxisomal targeting signal 2 receptor
Search

PEX7

0.92	Peroxisomal targeting signal 2 receptor

0.85	GO:0008611	ether lipid biosynthetic process
0.85	GO:0001958	endochondral ossification
0.82	GO:0001764	neuron migration
0.81	GO:0016558	protein import into peroxisome matrix
0.76	GO:0006635	fatty acid beta-oxidation
0.36	GO:0016573	histone acetylation

0.87	GO:0005053	peroxisome matrix targeting signal-2 binding
0.74	GO:0042803	protein homodimerization activity
0.70	GO:0019899	enzyme binding
0.37	GO:0004402	histone acetyltransferase activity

0.84	GO:0031907	microbody lumen
0.78	GO:0044439	peroxisomal part
0.68	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.37

GO:0004402

sp|O00629|IMA3_HUMAN
Importin subunit alpha-3
Search

KPNA4

0.60	Importin subunit alpha

0.79	GO:0006606	protein import into nucleus
0.52	GO:0042542	response to hydrogen peroxide
0.35	GO:0075733	intracellular transport of virus
0.35	GO:0044068	modulation by symbiont of host cellular process
0.34	GO:0019048	modulation by virus of host morphology or physiology
0.34	GO:1902594	multi-organism nuclear import
0.33	GO:0006461	protein complex assembly
0.33	GO:0051806	entry into cell of other organism involved in symbiotic interaction
0.33	GO:0044409	entry into host

0.82	GO:0061608	nuclear import signal receptor activity
0.69	GO:0008565	protein transporter activity
0.48	GO:0008139	nuclear localization sequence binding
0.41	GO:0008022	protein C-terminus binding

0.60	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.47	GO:0012505	endomembrane system
0.45	GO:0031967	organelle envelope
0.43	GO:0031090	organelle membrane
0.42	GO:0031974	membrane-enclosed lumen
0.39	GO:0043234	protein complex
0.36	GO:0070062	extracellular exosome
0.34	GO:0044216	other organism cell
0.34	GO:0018995	host

sp|O00631|SARCO_HUMAN
Sarcolipin
Search

SLN

0.97	Sarcolipin

0.77	GO:1901894	regulation of calcium-transporting ATPase activity
0.76	GO:1901077	regulation of relaxation of muscle
0.76	GO:0070296	sarcoplasmic reticulum calcium ion transport
0.44	GO:1901877	negative regulation of calcium ion binding
0.42	GO:0090281	negative regulation of calcium ion import
0.42	GO:1901020	negative regulation of calcium ion transmembrane transporter activity
0.42	GO:1901881	positive regulation of protein depolymerization
0.41	GO:0043242	negative regulation of protein complex disassembly
0.39	GO:0043086	negative regulation of catalytic activity

0.70	GO:0030234	enzyme regulator activity
0.42	GO:0051117	ATPase binding

0.72	GO:0016529	sarcoplasmic reticulum
0.60	GO:0005789	endoplasmic reticulum membrane
0.59	GO:0098588	bounding membrane of organelle
0.30	GO:0016021	integral component of membrane

sp|O00634|NET3_HUMAN
Netrin-3
Search

NTN3

0.92	LOW QUALITY PROTEIN: netrin-3

0.53	GO:0030516	regulation of axon extension
0.53	GO:0007409	axonogenesis
0.53	GO:0097485	neuron projection guidance
0.48	GO:0048513	animal organ development
0.48	GO:0060562	epithelial tube morphogenesis
0.47	GO:0048598	embryonic morphogenesis
0.47	GO:0051093	negative regulation of developmental process
0.47	GO:0051241	negative regulation of multicellular organismal process
0.47	GO:0021954	central nervous system neuron development
0.47	GO:0050772	positive regulation of axonogenesis

0.50

GO:0005102

receptor binding

0.66	GO:0005576	extracellular region
0.49	GO:0005794	Golgi apparatus
0.32	GO:0071944	cell periphery

sp|O00635|TRI38_HUMAN
E3 ubiquitin-protein ligase TRIM38
Search

0.93	Tripartite motif-containing protein 38

0.63	GO:0046598	positive regulation of viral entry into host cell
0.56	GO:0051091	positive regulation of DNA binding transcription factor activity
0.53	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.50	GO:1903321	negative regulation of protein modification by small protein conjugation or removal
0.49	GO:1902187	negative regulation of viral release from host cell
0.49	GO:0032897	negative regulation of viral transcription
0.48	GO:0016567	protein ubiquitination
0.47	GO:0045087	innate immune response
0.46	GO:0045861	negative regulation of proteolysis
0.46	GO:0090085	regulation of protein deubiquitination

0.62	GO:0008270	zinc ion binding
0.46	GO:0004842	ubiquitin-protein transferase activity
0.46	GO:0042802	identical protein binding
0.42	GO:0016874	ligase activity
0.39	GO:0008134	transcription factor binding
0.39	GO:0019904	protein domain specific binding
0.39	GO:0061659	ubiquitin-like protein ligase activity
0.36	GO:0035035	histone acetyltransferase binding
0.35	GO:0051427	hormone receptor binding
0.34	GO:0004871	signal transducer activity

0.44	GO:0005622	intracellular
0.41	GO:0043227	membrane-bounded organelle
0.40	GO:0031974	membrane-enclosed lumen
0.40	GO:1990234	transferase complex
0.38	GO:0044422	organelle part
0.34	GO:0043228	non-membrane-bounded organelle
0.33	GO:1990904	ribonucleoprotein complex
0.33	GO:0012505	endomembrane system
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.42	EC:6	GO:0016874
0.46	KEGG:R03876	GO:0004842

sp|O00712|NFIB_HUMAN
Nuclear factor 1 B-type
Search

NFIB

0.79	Nuclear factor 1 B-type

0.65	GO:0006260	DNA replication
0.62	GO:2000795	negative regulation of epithelial cell proliferation involved in lung morphogenesis
0.62	GO:0061141	lung ciliated cell differentiation
0.61	GO:0021740	principal sensory nucleus of trigeminal nerve development
0.61	GO:2000790	regulation of mesenchymal cell proliferation involved in lung development
0.61	GO:0060486	Clara cell differentiation
0.60	GO:0060509	Type I pneumocyte differentiation
0.60	GO:0060510	Type II pneumocyte differentiation
0.60	GO:0021960	anterior commissure morphogenesis
0.60	GO:0072201	negative regulation of mesenchymal cell proliferation

0.61	GO:0003700	DNA binding transcription factor activity
0.54	GO:0003677	DNA binding
0.51	GO:0001067	regulatory region nucleic acid binding
0.40	GO:0001106	RNA polymerase II transcription corepressor activity
0.32	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.60	GO:0044300	cerebellar mossy fiber
0.49	GO:0031974	membrane-enclosed lumen
0.45	GO:0043232	intracellular non-membrane-bounded organelle
0.44	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|O00716|E2F3_HUMAN
Transcription factor E2F3
Search

E2F3

0.94	Transcription factor E2F

0.70	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process
0.69	GO:0070345	negative regulation of fat cell proliferation
0.63	GO:0006366	transcription by RNA polymerase II
0.63	GO:0045944	positive regulation of transcription by RNA polymerase II
0.61	GO:0008284	positive regulation of cell proliferation
0.52	GO:1990086	lens fiber cell apoptotic process
0.51	GO:1903671	negative regulation of sprouting angiogenesis
0.49	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
0.45	GO:0051726	regulation of cell cycle

0.69	GO:0001047	core promoter binding
0.68	GO:0046983	protein dimerization activity
0.67	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.65	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.45	GO:0008134	transcription factor binding

0.74	GO:0005667	transcription factor complex
0.61	GO:0005634	nucleus
0.50	GO:0044446	intracellular organelle part

sp|O00743|PPP6_HUMAN
Serine/threonine-protein phosphatase 6 catalytic subunit
Search

PPP6C

0.51	Serine/threonine-protein phosphatase 6 catalytic subunit

0.70	GO:0006470	protein dephosphorylation
0.44	GO:0001878	response to yeast
0.37	GO:0045087	innate immune response
0.35	GO:0007049	cell cycle
0.35	GO:0048208	COPII vesicle coating

0.71	GO:0004721	phosphoprotein phosphatase activity
0.34	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.45	GO:0005829	cytosol
0.34	GO:0000139	Golgi membrane
0.33	GO:0005739	mitochondrion

0.71

GO:0004721

sp|O00744|WN10B_HUMAN
Protein Wnt-10b
Search

0.77	GO:0016055	Wnt signaling pathway
0.70	GO:0007275	multicellular organism development
0.59	GO:0051885	positive regulation of timing of anagen
0.59	GO:0014835	myoblast differentiation involved in skeletal muscle regeneration
0.58	GO:0071374	cellular response to parathyroid hormone stimulus
0.57	GO:0061430	bone trabecula morphogenesis
0.56	GO:0071320	cellular response to cAMP
0.55	GO:0045599	negative regulation of fat cell differentiation
0.55	GO:0030501	positive regulation of bone mineralization
0.55	GO:0048641	regulation of skeletal muscle tissue development

0.73	GO:0005102	receptor binding
0.47	GO:0030545	receptor regulator activity
0.36	GO:0005525	GTP binding

0.75	GO:0005578	proteinaceous extracellular matrix
0.47	GO:0005615	extracellular space
0.32	GO:0005622	intracellular
0.30	GO:0016020	membrane

sp|O00746|NDKM_HUMAN
Nucleoside diphosphate kinase, mitochondrial
Search

NME4

0.46	Nucleoside diphosphate kinase

0.78	GO:0006228	UTP biosynthetic process
0.78	GO:0006183	GTP biosynthetic process
0.75	GO:0046036	CTP metabolic process
0.70	GO:0006165	nucleoside diphosphate phosphorylation
0.48	GO:0006869	lipid transport
0.46	GO:0042981	regulation of apoptotic process
0.38	GO:0006171	cAMP biosynthetic process
0.37	GO:0015949	nucleobase-containing small molecule interconversion
0.34	GO:0006915	apoptotic process
0.33	GO:0090305	nucleic acid phosphodiester bond hydrolysis

0.79	GO:0004550	nucleoside diphosphate kinase activity
0.55	GO:1901612	cardiolipin binding
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0005515	protein binding
0.36	GO:0046872	metal ion binding
0.35	GO:0044877	macromolecular complex binding
0.34	GO:0003735	structural constituent of ribosome
0.33	GO:0004519	endonuclease activity

0.50	GO:0005758	mitochondrial intermembrane space
0.37	GO:0005759	mitochondrial matrix
0.37	GO:0070062	extracellular exosome
0.33	GO:0031966	mitochondrial membrane
0.33	GO:0019866	organelle inner membrane
0.33	GO:0005829	cytosol
0.33	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

0.79

EC:2.7.4.6

GO:0004550

sp|O00748|EST2_HUMAN
Cocaine esterase
Search

0.45	Carboxylic ester hydrolase

0.37	GO:0006692	prostanoid metabolic process
0.36	GO:0001523	retinoid metabolic process
0.35	GO:0010033	response to organic substance

0.51

GO:0016787

hydrolase activity

0.36	GO:0043227	membrane-bounded organelle
0.35	GO:0043229	intracellular organelle
0.35	GO:0043230	extracellular organelle
0.34	GO:0005615	extracellular space
0.30	GO:0031224	intrinsic component of membrane

0.51

GO:0016787

sp|O00750|P3C2B_HUMAN
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
Search

PIK3C2B

0.92	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

0.81	GO:0048015	phosphatidylinositol-mediated signaling
0.75	GO:0046854	phosphatidylinositol phosphorylation
0.74	GO:0043491	protein kinase B signaling
0.73	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
0.71	GO:1905037	autophagosome organization
0.67	GO:0009267	cellular response to starvation
0.54	GO:0016477	cell migration
0.48	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis
0.43	GO:0006897	endocytosis
0.42	GO:0001525	angiogenesis

0.76	GO:0035091	phosphatidylinositol binding
0.73	GO:0001727	lipid kinase activity
0.63	GO:0035004	phosphatidylinositol 3-kinase activity
0.57	GO:0052742	phosphatidylinositol kinase activity
0.56	GO:0016307	phosphatidylinositol phosphate kinase activity
0.36	GO:0005515	protein binding

0.69	GO:0030139	endocytic vesicle
0.61	GO:0005654	nucleoplasm
0.60	GO:0005829	cytosol
0.56	GO:0005942	phosphatidylinositol 3-kinase complex
0.44	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.63

GO:0035004

sp|O00754|MA2B1_HUMAN
Lysosomal alpha-mannosidase
Search

MAN2B1

0.47	Lysosomal alpha-mannosidase

0.81	GO:0006013	mannose metabolic process
0.51	GO:0006517	protein deglycosylation
0.49	GO:0007611	learning or memory
0.36	GO:0043312	neutrophil degranulation
0.36	GO:0009313	oligosaccharide catabolic process
0.33	GO:0007018	microtubule-based movement

0.79	GO:0004559	alpha-mannosidase activity
0.69	GO:0030246	carbohydrate binding
0.53	GO:0046872	metal ion binding
0.33	GO:0036094	small molecule binding
0.33	GO:0003777	microtubule motor activity
0.33	GO:0008017	microtubule binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.42	GO:0005764	lysosome
0.37	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.36	GO:0034774	secretory granule lumen
0.36	GO:0005775	vacuolar lumen
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:3.2.1.24

GO:0004559

sp|O00755|WNT7A_HUMAN
Protein Wnt-7a
Search

sp|O00757|F16P2_HUMAN
Fructose-1,6-bisphosphatase isozyme 2
Search

FBP2

0.52	Fructose-bisphosphatase 2

0.68	GO:0016311	dephosphorylation
0.60	GO:0005975	carbohydrate metabolic process
0.51	GO:0006002	fructose 6-phosphate metabolic process
0.50	GO:0030388	fructose 1,6-bisphosphate metabolic process
0.49	GO:0071286	cellular response to magnesium ion
0.49	GO:0045820	negative regulation of glycolytic process
0.47	GO:0051289	protein homotetramerization
0.47	GO:0006111	regulation of gluconeogenesis
0.47	GO:0046580	negative regulation of Ras protein signal transduction
0.47	GO:0030308	negative regulation of cell growth

0.79	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity
0.53	GO:0042802	identical protein binding
0.47	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding
0.46	GO:0016208	AMP binding
0.39	GO:0048029	monosaccharide binding
0.39	GO:0046872	metal ion binding

0.47	GO:0005654	nucleoplasm
0.45	GO:0005829	cytosol
0.41	GO:0005886	plasma membrane
0.40	GO:0030018	Z disc
0.38	GO:0030054	cell junction
0.38	GO:0070062	extracellular exosome
0.33	GO:0031012	extracellular matrix
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:3.1.3.11

GO:0042132

sp|O00762|UBE2C_HUMAN
Ubiquitin-conjugating enzyme E2 C
Search

UBE2C

0.91	Ubiquitin-conjugating enzyme E2 C

0.54	GO:0031145	anaphase-promoting complex-dependent catabolic process
0.53	GO:0000209	protein polyubiquitination
0.52	GO:0010994	free ubiquitin chain polymerization
0.52	GO:0010458	exit from mitosis
0.51	GO:0007088	regulation of mitotic nuclear division
0.51	GO:1901990	regulation of mitotic cell cycle phase transition
0.49	GO:0051785	positive regulation of nuclear division
0.49	GO:1901989	positive regulation of cell cycle phase transition
0.48	GO:0045931	positive regulation of mitotic cell cycle
0.47	GO:1902099	regulation of metaphase/anaphase transition of cell cycle

0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0044389	ubiquitin-like protein ligase binding
0.50	GO:0061631	ubiquitin conjugating enzyme activity
0.46	GO:0061630	ubiquitin protein ligase activity
0.36	GO:0016874	ligase activity

0.48	GO:0005680	anaphase-promoting complex
0.43	GO:0005829	cytosol
0.39	GO:0005886	plasma membrane
0.34	GO:0031616	spindle pole centrosome
0.34	GO:0005654	nucleoplasm

0.36

GO:0016874

sp|O00763|ACACB_HUMAN
Acetyl-CoA carboxylase 2
Search

ACACB

0.54	Acetyl-coenzyme A carboxylase beta

0.69	GO:0006633	fatty acid biosynthetic process
0.63	GO:0031999	negative regulation of fatty acid beta-oxidation
0.61	GO:0097009	energy homeostasis
0.61	GO:0010884	positive regulation of lipid storage
0.61	GO:0060421	positive regulation of heart growth
0.60	GO:0051289	protein homotetramerization
0.58	GO:0010906	regulation of glucose metabolic process
0.56	GO:2001295	malonyl-CoA biosynthetic process
0.55	GO:0031667	response to nutrient levels
0.54	GO:0006084	acetyl-CoA metabolic process

0.74	GO:0003989	acetyl-CoA carboxylase activity
0.74	GO:0004075	biotin carboxylase activity
0.54	GO:0030554	adenyl nucleotide binding
0.54	GO:0042802	identical protein binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0046872	metal ion binding
0.44	GO:0033293	monocarboxylic acid binding
0.43	GO:0033218	amide binding

0.47	GO:0005634	nucleus
0.47	GO:0005739	mitochondrion
0.36	GO:0012505	endomembrane system
0.36	GO:0031968	organelle outer membrane
0.35	GO:0005829	cytosol
0.32	GO:0015629	actin cytoskeleton
0.32	GO:0070013	intracellular organelle lumen

0.74

EC:6.4.1.2

GO:0003989

sp|O00764|PDXK_HUMAN
Pyridoxal kinase
Search

PDXK

0.56	Epididymis secretory sperm binding protein Li 1a

0.82	GO:0009443	pyridoxal 5'-phosphate salvage
0.57	GO:0016310	phosphorylation
0.51	GO:0008283	cell proliferation
0.36	GO:0043312	neutrophil degranulation
0.35	GO:0017085	response to insecticide
0.35	GO:0032094	response to food
0.35	GO:0032570	response to progesterone
0.35	GO:0014075	response to amine
0.35	GO:0010165	response to X-ray
0.34	GO:0043066	negative regulation of apoptotic process

0.82	GO:0008478	pyridoxal kinase activity
0.57	GO:0031403	lithium ion binding
0.52	GO:0031402	sodium ion binding
0.50	GO:0030955	potassium ion binding
0.49	GO:0042803	protein homodimerization activity
0.46	GO:0030170	pyridoxal phosphate binding
0.45	GO:0000287	magnesium ion binding
0.44	GO:0008270	zinc ion binding
0.41	GO:0032559	adenyl ribonucleotide binding
0.40	GO:0035639	purine ribonucleoside triphosphate binding

0.47	GO:0005654	nucleoplasm
0.43	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome
0.36	GO:0035580	specific granule lumen
0.34	GO:0030688	preribosome, small subunit precursor
0.30	GO:0031224	intrinsic component of membrane

0.82

EC:2.7.1.35

GO:0008478

sp|O00767|ACOD_HUMAN
Acyl-CoA desaturase
Search

SCD

0.47	River buffalo stearoyl CoA desaturase

0.70	GO:0006633	fatty acid biosynthetic process
0.58	GO:0033559	unsaturated fatty acid metabolic process
0.53	GO:0055114	oxidation-reduction process
0.42	GO:0070542	response to fatty acid
0.39	GO:1903699	tarsal gland development
0.39	GO:0034435	cholesterol esterification
0.39	GO:0050872	white fat cell differentiation
0.38	GO:0044130	negative regulation of growth of symbiont in host
0.38	GO:0033561	regulation of water loss via skin
0.38	GO:0050873	brown fat cell differentiation

0.80	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
0.45	GO:0005506	iron ion binding
0.33	GO:0008173	RNA methyltransferase activity

0.50	GO:0005789	endoplasmic reticulum membrane
0.47	GO:0005730	nucleolus
0.36	GO:0031090	organelle membrane
0.33	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.80

EC:1.14.19

GO:0016717

sp|O14490|DLGP1_HUMAN
Disks large-associated protein 1
Search

DLGAP1

0.93	DLG associated protein 1

0.78	GO:0098916	anterograde trans-synaptic signaling
0.46	GO:0006461	protein complex assembly

0.49

GO:0019904

protein domain specific binding

0.76	GO:0045202	synapse
0.62	GO:0097458	neuron part
0.46	GO:0043226	organelle

sp|O14492|SH2B2_HUMAN
SH2B adapter protein 2
Search

SH2B2

0.96	SH2B adapter protein 2

0.76	GO:0009967	positive regulation of signal transduction
0.64	GO:0001922	B-1 B cell homeostasis
0.61	GO:0008286	insulin receptor signaling pathway
0.61	GO:0035556	intracellular signal transduction
0.60	GO:0050851	antigen receptor-mediated signaling pathway
0.59	GO:0050873	brown fat cell differentiation
0.57	GO:0019221	cytokine-mediated signaling pathway
0.54	GO:0030036	actin cytoskeleton organization
0.44	GO:0019222	regulation of metabolic process
0.43	GO:0046425	regulation of JAK-STAT cascade

0.84	GO:0035591	signaling adaptor activity
0.62	GO:0004871	signal transducer activity
0.60	GO:0030971	receptor tyrosine kinase binding
0.58	GO:0030674	protein binding, bridging
0.38	GO:0042802	identical protein binding

0.60	GO:0097517	contractile actin filament bundle
0.60	GO:0042641	actomyosin
0.59	GO:0001726	ruffle
0.59	GO:0005884	actin filament
0.52	GO:0005829	cytosol
0.40	GO:0030173	integral component of Golgi membrane
0.36	GO:0005886	plasma membrane

sp|O14493|CLD4_HUMAN
Claudin-4
Search

CLDN4

0.69

Claudin

0.57	GO:0070293	renal absorption
0.56	GO:0061436	establishment of skin barrier
0.54	GO:0045216	cell-cell junction organization
0.52	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
0.51	GO:1902476	chloride transmembrane transport
0.48	GO:0003382	epithelial cell morphogenesis
0.47	GO:0051291	protein heterooligomerization
0.46	GO:0034329	cell junction assembly
0.46	GO:0001666	response to hypoxia
0.45	GO:0051260	protein homooligomerization

0.62	GO:0005198	structural molecule activity
0.52	GO:0005254	chloride channel activity
0.51	GO:0104005	hijacked molecular function
0.46	GO:0042802	identical protein binding
0.35	GO:0099600	transmembrane receptor activity
0.34	GO:0038023	signaling receptor activity
0.31	GO:0016787	hydrolase activity

0.81	GO:0005923	bicellular tight junction
0.66	GO:0016327	apicolateral plasma membrane
0.50	GO:0016328	lateral plasma membrane
0.47	GO:0005887	integral component of plasma membrane
0.41	GO:0045178	basal part of cell
0.40	GO:0045177	apical part of cell
0.40	GO:0016323	basolateral plasma membrane
0.39	GO:0034707	chloride channel complex
0.36	GO:0043227	membrane-bounded organelle
0.35	GO:0043229	intracellular organelle

0.31

GO:0016787

sp|O14494|PLPP1_HUMAN
Phospholipid phosphatase 1
Search

PLPP1

0.94	Lipid phosphate phosphohydrolase 1

0.68	GO:0016311	dephosphorylation
0.63	GO:0006629	lipid metabolic process
0.44	GO:0036211	protein modification process
0.42	GO:0044267	cellular protein metabolic process
0.40	GO:0007165	signal transduction
0.39	GO:0019637	organophosphate metabolic process
0.35	GO:0008354	germ cell migration
0.35	GO:0019216	regulation of lipid metabolic process
0.35	GO:0008285	negative regulation of cell proliferation
0.35	GO:0071383	cellular response to steroid hormone stimulus

0.85	GO:0008195	phosphatidate phosphatase activity
0.58	GO:0042577	lipid phosphatase activity
0.36	GO:0042392	sphingosine-1-phosphate phosphatase activity

0.56	GO:0005886	plasma membrane
0.36	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.85

EC:3.1.3.4

GO:0008195

sp|O14495|PLPP3_HUMAN
Phospholipid phosphatase 3
Search

0.91	Lipid phosphate phosphohydrolase 3

0.81	GO:0030111	regulation of Wnt signaling pathway
0.68	GO:0016311	dephosphorylation
0.67	GO:0006644	phospholipid metabolic process
0.58	GO:1902068	regulation of sphingolipid mediated signaling pathway
0.56	GO:0060020	Bergmann glial cell differentiation
0.55	GO:0060070	canonical Wnt signaling pathway
0.55	GO:0001702	gastrulation with mouth forming second
0.53	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
0.53	GO:0051091	positive regulation of DNA binding transcription factor activity
0.52	GO:0050821	protein stabilization

0.86	GO:0042577	lipid phosphatase activity
0.60	GO:0042392	sphingosine-1-phosphate phosphatase activity
0.54	GO:0005178	integrin binding
0.49	GO:0008195	phosphatidate phosphatase activity
0.35	GO:0004721	phosphoprotein phosphatase activity

0.43	GO:0005886	plasma membrane
0.37	GO:0012505	endomembrane system
0.37	GO:0070062	extracellular exosome
0.36	GO:0031984	organelle subcompartment
0.35	GO:0005912	adherens junction
0.35	GO:0043231	intracellular membrane-bounded organelle
0.35	GO:0044444	cytoplasmic part
0.30	GO:0016021	integral component of membrane

0.49

EC:3.1.3.4

GO:0008195

sp|O14497|ARI1A_HUMAN
AT-rich interactive domain-containing protein 1A
Search

ARID1A

0.89	AT-rich interactive domain-containing protein 1A

0.77	GO:0006338	chromatin remodeling
0.36	GO:0006506	GPI anchor biosynthetic process
0.36	GO:0097502	mannosylation
0.36	GO:0003408	optic cup formation involved in camera-type eye development
0.36	GO:0006344	maintenance of chromatin silencing
0.35	GO:0007566	embryo implantation
0.35	GO:0060674	placenta blood vessel development
0.35	GO:0055007	cardiac muscle cell differentiation
0.35	GO:0001843	neural tube closure
0.35	GO:0001704	formation of primary germ layer

0.54	GO:0003677	DNA binding
0.37	GO:0004584	dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity
0.35	GO:0031491	nucleosome binding
0.34	GO:0016922	ligand-dependent nuclear receptor binding
0.32	GO:0003713	transcription coactivator activity

0.76	GO:0070603	SWI/SNF superfamily-type complex
0.34	GO:0097458	neuron part
0.34	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

0.37

EC:2.4.1.130

GO:0004584

sp|O14498|ISLR_HUMAN
Immunoglobulin superfamily containing leucine-rich repeat protein
Search

ISLR

0.97	Mesenchymal stromal cell-and fibroblast-expressing Linx paralogue

0.48	GO:0007155	cell adhesion
0.45	GO:0045773	positive regulation of axon extension
0.39	GO:0002576	platelet degranulation
0.34	GO:0034138	toll-like receptor 3 signaling pathway
0.34	GO:0002756	MyD88-independent toll-like receptor signaling pathway
0.34	GO:0043330	response to exogenous dsRNA
0.34	GO:0032722	positive regulation of chemokine production
0.34	GO:0045087	innate immune response
0.33	GO:0050729	positive regulation of inflammatory response
0.33	GO:0051607	defense response to virus

0.37	GO:0005515	protein binding
0.33	GO:0003725	double-stranded RNA binding
0.33	GO:0004888	transmembrane signaling receptor activity

0.59	GO:0005615	extracellular space
0.42	GO:0009986	cell surface
0.40	GO:1903561	extracellular vesicle
0.39	GO:0031093	platelet alpha granule lumen
0.34	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O14503|BHE40_HUMAN
Class E basic helix-loop-helix protein 40
Search

BHLHE40

0.97	Class E basic helix-loop-helix protein 40

0.60	GO:0032922	circadian regulation of gene expression
0.60	GO:0043153	entrainment of circadian clock by photoperiod
0.57	GO:0006351	transcription, DNA-templated
0.56	GO:0043433	negative regulation of DNA binding transcription factor activity
0.55	GO:0000122	negative regulation of transcription by RNA polymerase II
0.39	GO:0010944	negative regulation of transcription by competitive promoter binding
0.39	GO:0010832	negative regulation of myotube differentiation
0.38	GO:0045475	locomotor rhythm
0.36	GO:0048168	regulation of neuronal synaptic plasticity
0.35	GO:0007399	nervous system development

0.65	GO:0046983	protein dimerization activity
0.63	GO:0043426	MRF binding
0.61	GO:0070888	E-box binding
0.59	GO:0001102	RNA polymerase II activating transcription factor binding
0.59	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding
0.59	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.58	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.57	GO:0003714	transcription corepressor activity
0.53	GO:0019904	protein domain specific binding
0.52	GO:0042802	identical protein binding

0.60	GO:0005634	nucleus
0.48	GO:0031974	membrane-enclosed lumen
0.44	GO:0044446	intracellular organelle part
0.34	GO:0005737	cytoplasm
0.33	GO:0017053	transcriptional repressor complex

sp|O14508|SOCS2_HUMAN
Suppressor of cytokine signaling 2
Search

SOCS2

0.97	Suppressor of cytokine signaling 2

0.82	GO:0046426	negative regulation of JAK-STAT cascade
0.73	GO:0001558	regulation of cell growth
0.64	GO:0016567	protein ubiquitination
0.62	GO:0035556	intracellular signal transduction
0.58	GO:0040015	negative regulation of multicellular organism growth
0.57	GO:0060396	growth hormone receptor signaling pathway
0.57	GO:0032355	response to estradiol
0.56	GO:0061377	mammary gland lobule development
0.56	GO:0007595	lactation
0.54	GO:0045666	positive regulation of neuron differentiation

0.83	GO:0008269	JAK pathway signal transduction adaptor activity
0.82	GO:0005159	insulin-like growth factor receptor binding
0.57	GO:0005131	growth hormone receptor binding
0.48	GO:0019210	kinase inhibitor activity
0.46	GO:0019887	protein kinase regulator activity
0.35	GO:0005070	SH3/SH2 adaptor activity
0.35	GO:0019901	protein kinase binding
0.34	GO:0070513	death domain binding
0.32	GO:0003779	actin binding

0.47	GO:0005737	cytoplasm
0.35	GO:0035770	ribonucleoprotein granule
0.34	GO:0005886	plasma membrane
0.34	GO:0005654	nucleoplasm

sp|O14511|NRG2_HUMAN
Pro-neuregulin-2, membrane-bound isoform
Search

NRG2

0.92	Pro-neuregulin-2, membrane-bound

0.46	GO:0048513	animal organ development
0.41	GO:0035556	intracellular signal transduction
0.41	GO:0061384	heart trabecula morphogenesis
0.40	GO:0048864	stem cell development
0.40	GO:0007422	peripheral nervous system development
0.40	GO:0008544	epidermis development
0.40	GO:0001667	ameboidal-type cell migration
0.40	GO:0014706	striated muscle tissue development
0.39	GO:0061061	muscle structure development
0.39	GO:0048729	tissue morphogenesis

0.44	GO:0005102	receptor binding
0.39	GO:0030545	receptor regulator activity
0.38	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.38	GO:0004713	protein tyrosine kinase activity
0.36	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.35	GO:0019199	transmembrane receptor protein kinase activity
0.32	GO:0016817	hydrolase activity, acting on acid anhydrides

0.44	GO:0005615	extracellular space
0.35	GO:0005886	plasma membrane
0.35	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

0.38	EC:2.7.1.153	GO:0046934
0.38	KEGG:R04545	GO:0046934

sp|O14512|SOCS7_HUMAN
Suppressor of cytokine signaling 7
Search

SOCS7

0.88	Suppressor of cytokine signaling 7

0.63	GO:0016567	protein ubiquitination
0.62	GO:0035556	intracellular signal transduction
0.60	GO:0021942	radial glia guided migration of Purkinje cell
0.59	GO:0021819	layer formation in cerebral cortex
0.57	GO:0008286	insulin receptor signaling pathway
0.56	GO:0045444	fat cell differentiation
0.50	GO:0046426	negative regulation of JAK-STAT cascade
0.48	GO:0006469	negative regulation of protein kinase activity
0.47	GO:0019221	cytokine-mediated signaling pathway
0.39	GO:0040008	regulation of growth

0.48	GO:0004860	protein kinase inhibitor activity
0.36	GO:0017124	SH3 domain binding

0.48	GO:0005829	cytosol
0.36	GO:0005634	nucleus
0.35	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O14513|NCKP5_HUMAN
Nck-associated protein 5
Search

NCKAP5

0.92	Nck-associated protein 5

sp|O14514|BAI1_HUMAN
Brain-specific angiogenesis inhibitor 1
Search

ADGRB1

0.92	Adhesion G protein-coupled receptor B1

0.84	GO:0016525	negative regulation of angiogenesis
0.78	GO:0043652	engulfment of apoptotic cell
0.72	GO:1901741	positive regulation of myoblast fusion
0.71	GO:1903428	positive regulation of reactive oxygen species biosynthetic process
0.71	GO:0010596	negative regulation of endothelial cell migration
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.70	GO:0006910	phagocytosis, recognition
0.70	GO:0007166	cell surface receptor signaling pathway
0.69	GO:0051965	positive regulation of synapse assembly
0.69	GO:0031397	negative regulation of protein ubiquitination

0.72	GO:0004930	G-protein coupled receptor activity
0.70	GO:0001786	phosphatidylserine binding
0.69	GO:0030165	PDZ domain binding
0.67	GO:0001530	lipopolysaccharide binding

0.71	GO:0001891	phagocytic cup
0.68	GO:0014069	postsynaptic density
0.66	GO:0005925	focal adhesion
0.66	GO:0030425	dendrite
0.65	GO:0048471	perinuclear region of cytoplasm
0.61	GO:0005615	extracellular space
0.48	GO:0044309	neuron spine
0.46	GO:0045211	postsynaptic membrane
0.39	GO:0005911	cell-cell junction
0.37	GO:0005887	integral component of plasma membrane

sp|O14519|CDKA1_HUMAN
Cyclin-dependent kinase 2-associated protein 1
Search

CDK2AP1

0.95	Cyclin-dependent kinase 2-associated protein 1

0.52	GO:0016310	phosphorylation
0.50	GO:2000035	regulation of stem cell division
0.50	GO:0001934	positive regulation of protein phosphorylation
0.50	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle
0.47	GO:0070507	regulation of microtubule cytoskeleton organization
0.38	GO:0060325	face morphogenesis
0.37	GO:0001701	in utero embryonic development
0.36	GO:0007049	cell cycle
0.34	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process

0.55	GO:0070182	DNA polymerase binding
0.54	GO:0016301	kinase activity
0.34	GO:0005509	calcium ion binding
0.34	GO:0005548	phospholipid transporter activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.33	GO:0140096	catalytic activity, acting on a protein

0.51	GO:0048471	perinuclear region of cytoplasm
0.47	GO:0005654	nucleoplasm
0.47	GO:0005829	cytosol
0.44	GO:0005874	microtubule
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0016773

sp|O14520|AQP7_HUMAN
Aquaporin-7
Search

AQP7

0.97	Aquaporin-7

0.59	GO:0015793	glycerol transport
0.57	GO:0006833	water transport
0.55	GO:0055085	transmembrane transport
0.55	GO:0003091	renal water homeostasis
0.54	GO:0070293	renal absorption
0.44	GO:0015840	urea transport
0.36	GO:0007588	excretion
0.35	GO:0015700	arsenite transport
0.34	GO:0007283	spermatogenesis
0.33	GO:0042493	response to drug

0.69	GO:0022803	passive transmembrane transporter activity
0.48	GO:0015168	glycerol transmembrane transporter activity
0.46	GO:0005372	water transmembrane transporter activity
0.44	GO:0015204	urea transmembrane transporter activity
0.35	GO:0015105	arsenite transmembrane transporter activity

0.37	GO:0005911	cell-cell junction
0.35	GO:0044459	plasma membrane part
0.35	GO:0070062	extracellular exosome
0.35	GO:0005903	brush border
0.34	GO:0046930	pore complex
0.34	GO:0120038	plasma membrane bounded cell projection part
0.33	GO:0005737	cytoplasm
0.33	GO:0030529	intracellular ribonucleoprotein complex

sp|O14521|DHSD_HUMAN
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Search

SDHD

0.71	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit

0.70	GO:0006099	tricarboxylic acid cycle
0.52	GO:0050433	regulation of catecholamine secretion
0.51	GO:0071456	cellular response to hypoxia
0.50	GO:0006121	mitochondrial electron transport, succinate to ubiquinone

0.53	GO:0046872	metal ion binding
0.53	GO:0048039	ubiquinone binding
0.53	GO:0000104	succinate dehydrogenase activity
0.46	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
0.43	GO:0020037	heme binding
0.33	GO:0009055	electron transfer activity
0.33	GO:0005515	protein binding

0.61	GO:0031966	mitochondrial membrane
0.61	GO:0019866	organelle inner membrane
0.52	GO:0045257	succinate dehydrogenase complex (ubiquinone)
0.52	GO:0045283	fumarate reductase complex
0.47	GO:0098798	mitochondrial protein complex
0.31	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.53

EC:1.3.99.1

GO:0000104

sp|O14522|PTPRT_HUMAN
Receptor-type tyrosine-protein phosphatase T
Search

PTPRT

0.40	Receptor-type tyrosine-protein phosphatase T

0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.39	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.39	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

0.74	GO:0004725	protein tyrosine phosphatase activity
0.53	GO:0070097	delta-catenin binding
0.52	GO:0045295	gamma-catenin binding
0.52	GO:0045294	alpha-catenin binding
0.50	GO:0051393	alpha-actinin binding
0.50	GO:0008013	beta-catenin binding
0.49	GO:0045296	cadherin binding
0.46	GO:0016790	thiolester hydrolase activity

0.38	GO:0009986	cell surface
0.35	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.74

GO:0004725

sp|O14523|C2C2L_HUMAN
Phospholipid transfer protein C2CD2L
Search

C2CD2L

0.87	C2 domain-containing protein 2

0.70	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
0.63	GO:0015914	phospholipid transport
0.34	GO:0006396	RNA processing

0.73	GO:0043559	insulin binding
0.71	GO:0008526	phosphatidylinositol transporter activity
0.62	GO:0035091	phosphatidylinositol binding
0.31	GO:0003676	nucleic acid binding

0.73	GO:0098592	cytoplasmic side of apical plasma membrane
0.70	GO:0032541	cortical endoplasmic reticulum
0.38	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O14524|NEMP1_HUMAN
Nuclear envelope integral membrane protein 1
Search

NEMP1

0.46	Nuclear envelope integral membrane protein 1

0.37	GO:0001654	eye development
0.36	GO:0045892	negative regulation of transcription, DNA-templated
0.34	GO:0007018	microtubule-based movement
0.34	GO:0007165	signal transduction

0.37	GO:0043621	protein self-association
0.34	GO:0004871	signal transducer activity
0.34	GO:0003777	microtubule motor activity
0.34	GO:0008017	microtubule binding
0.34	GO:0003700	DNA binding transcription factor activity
0.34	GO:0003779	actin binding
0.33	GO:0003677	DNA binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.57	GO:0005635	nuclear envelope
0.38	GO:0019866	organelle inner membrane
0.34	GO:0016459	myosin complex
0.30	GO:0031224	intrinsic component of membrane

sp|O14525|ASTN1_HUMAN
Astrotactin-1
Search

ASTN1

0.97	Astrotactin

0.60	GO:0007158	neuron cell-cell adhesion
0.57	GO:0001764	neuron migration
0.55	GO:0007626	locomotory behavior
0.34	GO:2000009	negative regulation of protein localization to cell surface

0.34	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding
0.33	GO:0005515	protein binding
0.33	GO:0005509	calcium ion binding

0.55	GO:0009897	external side of plasma membrane
0.53	GO:0005768	endosome
0.37	GO:0043204	perikaryon
0.36	GO:0030136	clathrin-coated vesicle
0.34	GO:0060187	cell pole
0.30	GO:0031224	intrinsic component of membrane

sp|O14526|FCHO1_HUMAN
F-BAR domain only protein 1
Search

FCHO1

0.92	F-BAR domain only protein 1

0.72	GO:0072583	clathrin-dependent endocytosis
0.42	GO:0048268	clathrin coat assembly
0.36	GO:0030509	BMP signaling pathway
0.35	GO:0009953	dorsal/ventral pattern formation
0.35	GO:0061024	membrane organization
0.33	GO:0015031	protein transport

0.43

GO:0035612

AP-2 adaptor complex binding

0.53	GO:0005654	nucleoplasm
0.52	GO:0005829	cytosol
0.42	GO:0005905	clathrin-coated pit
0.39	GO:0030136	clathrin-coated vesicle
0.36	GO:0005886	plasma membrane

sp|O14529|CUX2_HUMAN
Homeobox protein cut-like 2
Search

CUX2

0.75	Homeobox protein cut-like

0.62	GO:0061003	positive regulation of dendritic spine morphogenesis
0.61	GO:2000463	positive regulation of excitatory postsynaptic potential
0.61	GO:0007614	short-term memory
0.59	GO:0051965	positive regulation of synapse assembly
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.55	GO:0006351	transcription, DNA-templated
0.52	GO:1902679	negative regulation of RNA biosynthetic process
0.51	GO:0010604	positive regulation of macromolecule metabolic process

0.61	GO:0043565	sequence-specific DNA binding
0.57	GO:0001012	RNA polymerase II regulatory region DNA binding
0.56	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.54	GO:0003690	double-stranded DNA binding
0.32	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
0.32	GO:0030674	protein binding, bridging
0.31	GO:0003682	chromatin binding

0.60	GO:0005634	nucleus
0.47	GO:0000139	Golgi membrane
0.33	GO:0043233	organelle lumen
0.31	GO:0043005	neuron projection
0.30	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

sp|O14530|TXND9_HUMAN
Thioredoxin domain-containing protein 9
Search

TXNDC9

0.96	Thioredoxin domain-containing protein 9

0.66	GO:0045454	cell redox homeostasis
0.45	GO:0008616	queuosine biosynthetic process
0.33	GO:0016998	cell wall macromolecule catabolic process
0.33	GO:0009253	peptidoglycan catabolic process

0.54	GO:0045296	cadherin binding
0.47	GO:0008479	queuine tRNA-ribosyltransferase activity
0.34	GO:0003796	lysozyme activity

0.54	GO:0030496	midbody
0.52	GO:0005813	centrosome
0.48	GO:0005829	cytosol
0.45	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.47

EC:2.4.2.29

GO:0008479

sp|O14531|DPYL4_HUMAN
Dihydropyrimidinase-related protein 4
Search

DPYSL4

0.93	Dihydropyrimidinase like 4

0.78	GO:0097485	neuron projection guidance
0.73	GO:0070997	neuron death
0.62	GO:0010975	regulation of neuron projection development
0.60	GO:0061387	regulation of extent of cell growth
0.58	GO:0010769	regulation of cell morphogenesis involved in differentiation
0.58	GO:0048638	regulation of developmental growth
0.58	GO:0007409	axonogenesis
0.57	GO:0007420	brain development
0.56	GO:0007010	cytoskeleton organization
0.51	GO:0048678	response to axon injury

0.65	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
0.59	GO:0008092	cytoskeletal protein binding
0.44	GO:0019900	kinase binding
0.38	GO:0051219	phosphoprotein binding
0.35	GO:0016301	kinase activity
0.35	GO:0042802	identical protein binding

0.48	GO:0005737	cytoplasm
0.43	GO:0043209	myelin sheath
0.42	GO:0043025	neuronal cell body
0.42	GO:0030425	dendrite
0.42	GO:0030424	axon
0.37	GO:0030426	growth cone
0.37	GO:0015630	microtubule cytoskeleton
0.37	GO:0044430	cytoskeletal part
0.36	GO:0099512	supramolecular fiber
0.36	GO:0043231	intracellular membrane-bounded organelle

0.65

EC:3.5

GO:0016810

sp|O14543|SOCS3_HUMAN
Suppressor of cytokine signaling 3
Search

SOCS3

0.97	Suppressor of cytokine signaling 3

0.85	GO:0007259	JAK-STAT cascade
0.78	GO:0043066	negative regulation of apoptotic process
0.68	GO:0016567	protein ubiquitination
0.65	GO:0060708	spongiotrophoblast differentiation
0.64	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein
0.64	GO:0046627	negative regulation of insulin receptor signaling pathway
0.63	GO:0060670	branching involved in labyrinthine layer morphogenesis
0.63	GO:0060707	trophoblast giant cell differentiation
0.62	GO:0060674	placenta blood vessel development
0.61	GO:0050728	negative regulation of inflammatory response

0.62	GO:0001784	phosphotyrosine residue binding
0.49	GO:0004860	protein kinase inhibitor activity
0.36	GO:0008269	JAK pathway signal transduction adaptor activity
0.36	GO:0005159	insulin-like growth factor receptor binding

0.45

GO:0005622

intracellular

sp|O14544|SOCS6_HUMAN
Suppressor of cytokine signaling 6
Search

SOCS6

0.97	Suppressor of cytokine signaling 6

0.78	GO:0040008	regulation of growth
0.73	GO:0016567	protein ubiquitination
0.62	GO:0035556	intracellular signal transduction
0.51	GO:0050868	negative regulation of T cell activation
0.50	GO:0010498	proteasomal protein catabolic process
0.48	GO:0046426	negative regulation of JAK-STAT cascade
0.46	GO:0006469	negative regulation of protein kinase activity
0.46	GO:0019221	cytokine-mediated signaling pathway
0.36	GO:0001678	cellular glucose homeostasis
0.35	GO:0006952	defense response

0.47	GO:0004860	protein kinase inhibitor activity
0.34	GO:0005515	protein binding

0.55	GO:0001772	immunological synapse
0.45	GO:0005622	intracellular

sp|O14545|TRAD1_HUMAN
TRAF-type zinc finger domain-containing protein 1
Search

TRAFD1

0.96	TRAF-type zinc finger domain-containing protein 1

0.68	GO:0045824	negative regulation of innate immune response
0.55	GO:0034097	response to cytokine

0.48	GO:0008270	zinc ion binding
0.38	GO:0005515	protein binding
0.32	GO:0003676	nucleic acid binding

0.30

GO:0016021

integral component of membrane

sp|O14548|COX7R_HUMAN
Cytochrome c oxidase subunit 7A-related protein, mitochondrial
Search

COX7A2L

0.97	Cytochrome c oxidase subunit VIIa polypeptide 2 like

0.63	GO:1902600	hydrogen ion transmembrane transport
0.61	GO:0022900	electron transport chain
0.40	GO:0097250	mitochondrial respiratory chain supercomplex assembly
0.40	GO:0002082	regulation of oxidative phosphorylation
0.33	GO:0006119	oxidative phosphorylation
0.33	GO:0009060	aerobic respiration

0.65	GO:0015002	heme-copper terminal oxidase activity
0.65	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.62	GO:0009055	electron transfer activity

0.79	GO:0005746	mitochondrial respiratory chain
0.48	GO:0005730	nucleolus
0.41	GO:0097249	mitochondrial respiratory chain supercomplex
0.30	GO:0031224	intrinsic component of membrane

0.65

EC:1.9.3

GO:0016676

sp|O14556|G3PT_HUMAN
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Search

GAPDHS

0.49	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

0.70	GO:0006006	glucose metabolic process
0.68	GO:0006757	ATP generation from ADP
0.67	GO:0006090	pyruvate metabolic process
0.66	GO:0016052	carbohydrate catabolic process
0.65	GO:0019362	pyridine nucleotide metabolic process
0.53	GO:0055114	oxidation-reduction process
0.36	GO:0045821	positive regulation of glycolytic process
0.36	GO:0030317	flagellated sperm motility
0.35	GO:0035606	peptidyl-cysteine S-trans-nitrosylation
0.35	GO:0051402	neuron apoptotic process

0.80	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
0.69	GO:0050661	NADP binding
0.67	GO:0051287	NAD binding
0.35	GO:0035605	peptidyl-cysteine S-nitrosylase activity
0.34	GO:0005515	protein binding

0.35	GO:0005829	cytosol
0.34	GO:0005634	nucleus
0.33	GO:0015630	microtubule cytoskeleton
0.32	GO:0035686	sperm fibrous sheath
0.32	GO:0097228	sperm principal piece
0.32	GO:0001669	acrosomal vesicle
0.30	GO:0016020	membrane

0.80

EC:1.2.1.12

GO:0004365

sp|O14558|HSPB6_HUMAN
Heat shock protein beta-6
Search

HSPB6

0.93	Alpha-crystallin A chain

0.57	GO:0045766	positive regulation of angiogenesis
0.54	GO:0061077	chaperone-mediated protein folding
0.48	GO:0070309	lens fiber cell morphogenesis
0.48	GO:0070141	response to UV-A
0.48	GO:0060561	apoptotic process involved in morphogenesis
0.47	GO:0043066	negative regulation of apoptotic process
0.47	GO:0048596	embryonic camera-type eye morphogenesis
0.46	GO:2000117	negative regulation of cysteine-type endopeptidase activity
0.46	GO:0007021	tubulin complex assembly
0.46	GO:0042542	response to hydrogen peroxide

0.85	GO:0005212	structural constituent of eye lens
0.54	GO:0051087	chaperone binding
0.52	GO:0051082	unfolded protein binding
0.41	GO:0042802	identical protein binding
0.40	GO:0046872	metal ion binding
0.39	GO:0046983	protein dimerization activity
0.34	GO:0001540	amyloid-beta binding
0.33	GO:0032403	protein complex binding

0.51	GO:0005634	nucleus
0.49	GO:0005576	extracellular region
0.43	GO:0005737	cytoplasm
0.35	GO:0043233	organelle lumen
0.35	GO:0031982	vesicle
0.34	GO:0044446	intracellular organelle part
0.33	GO:0043209	myelin sheath
0.33	GO:0099512	supramolecular fiber
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.32	GO:0005886	plasma membrane

sp|O14559|RHG33_HUMAN
Rho GTPase-activating protein 33
Search

ARHGAP33

0.96	Rho GTPase-activating protein 33

0.66	GO:0043547	positive regulation of GTPase activity
0.60	GO:0007165	signal transduction
0.57	GO:0015031	protein transport
0.37	GO:0051056	regulation of small GTPase mediated signal transduction

0.73	GO:0035091	phosphatidylinositol binding
0.66	GO:0005096	GTPase activator activity
0.54	GO:0019901	protein kinase binding

0.50	GO:0005938	cell cortex
0.49	GO:0015629	actin cytoskeleton
0.44	GO:0043234	protein complex
0.43	GO:0001650	fibrillar center
0.43	GO:0005886	plasma membrane
0.40	GO:0005794	Golgi apparatus
0.40	GO:0005654	nucleoplasm
0.36	GO:0005829	cytosol
0.36	GO:0043197	dendritic spine
0.36	GO:0014069	postsynaptic density

sp|O14561|ACPM_HUMAN
Acyl carrier protein, mitochondrial
Search

NDUFAB1

0.44	Acyl carrier protein, mitochondrial

0.70	GO:0006633	fatty acid biosynthetic process
0.55	GO:0032981	mitochondrial respiratory chain complex I assembly
0.50	GO:0009249	protein lipoylation
0.46	GO:0009245	lipid A biosynthetic process
0.36	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
0.35	GO:0006635	fatty acid beta-oxidation

0.52	GO:0000035	acyl binding
0.48	GO:0000036	acyl carrier activity
0.46	GO:0031177	phosphopantetheine binding
0.37	GO:0005504	fatty acid binding
0.35	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.34	GO:0005509	calcium ion binding
0.33	GO:0005515	protein binding
0.32	GO:0003676	nucleic acid binding

0.53	GO:0005747	mitochondrial respiratory chain complex I
0.47	GO:0005654	nucleoplasm
0.44	GO:0005829	cytosol
0.36	GO:0005759	mitochondrial matrix
0.30	GO:0016021	integral component of membrane

0.35

GO:0008137

sp|O14562|UBFD1_HUMAN
Ubiquitin domain-containing protein UBFD1
Search

UBFD1

0.93	To Ubiquitin domain-containing protein UBFD1

0.39	GO:0006397	mRNA processing
0.39	GO:0090501	RNA phosphodiester bond hydrolysis
0.38	GO:0006468	protein phosphorylation

0.79	GO:0045296	cadherin binding
0.40	GO:0003723	RNA binding
0.39	GO:0004540	ribonuclease activity
0.38	GO:0004672	protein kinase activity
0.36	GO:0030554	adenyl nucleotide binding
0.36	GO:0097367	carbohydrate derivative binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0008144	drug binding

sp|O14569|C56D2_HUMAN
Cytochrome b561 domain-containing protein 2
Search

CYB561D2

0.96	Cytochrome b-561 domain containing 2

0.52

GO:0055114

oxidation-reduction process

0.35

GO:0046872

metal ion binding

0.30

GO:0044425

membrane part

sp|O14576|DC1I1_HUMAN
Cytoplasmic dynein 1 intermediate chain 1
Search

DYNC1I1

0.88	Cytoplasmic dynein 1 intermediate chain 1

0.70	GO:0007018	microtubule-based movement
0.56	GO:0099518	vesicle cytoskeletal trafficking
0.49	GO:2000582	positive regulation of ATP-dependent microtubule motor activity, plus-end-directed
0.36	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.35	GO:0007420	brain development
0.35	GO:0006888	ER to Golgi vesicle-mediated transport
0.35	GO:0007062	sister chromatid cohesion
0.34	GO:0075733	intracellular transport of virus

0.59	GO:0045503	dynein light chain binding
0.56	GO:0030507	spectrin binding
0.49	GO:0045504	dynein heavy chain binding
0.48	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed
0.37	GO:0008017	microtubule binding

0.78	GO:0005868	cytoplasmic dynein complex
0.54	GO:0055037	recycling endosome
0.53	GO:0000922	spindle pole
0.53	GO:0036464	cytoplasmic ribonucleoprotein granule
0.52	GO:0000776	kinetochore
0.45	GO:0005634	nucleus
0.39	GO:0005874	microtubule
0.38	GO:0000779	condensed chromosome, centromeric region
0.38	GO:0005813	centrosome
0.38	GO:0048471	perinuclear region of cytoplasm

0.48

EC:3.6.4.4

GO:0008574

sp|O14578|CTRO_HUMAN
Citron Rho-interacting kinase
Search

CIT

0.95	Citron Rho-interacting kinase

0.75	GO:0000281	mitotic cytokinesis
0.62	GO:0035556	intracellular signal transduction
0.61	GO:0006468	protein phosphorylation
0.53	GO:0051402	neuron apoptotic process
0.52	GO:0032467	positive regulation of cytokinesis
0.42	GO:0044772	mitotic cell cycle phase transition
0.42	GO:0044839	cell cycle G2/M phase transition
0.41	GO:0007030	Golgi organization
0.40	GO:0008064	regulation of actin polymerization or depolymerization
0.40	GO:0048699	generation of neurons

0.68	GO:0004674	protein serine/threonine kinase activity
0.53	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0097110	scaffold protein binding
0.53	GO:0030165	PDZ domain binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0046872	metal ion binding
0.40	GO:0017048	Rho GTPase binding
0.39	GO:0017124	SH3 domain binding
0.36	GO:0004713	protein tyrosine kinase activity

0.45	GO:0005622	intracellular
0.42	GO:0097610	cell surface furrow
0.41	GO:0030496	midbody
0.41	GO:0032155	cell division site part
0.41	GO:0043025	neuronal cell body
0.38	GO:0001726	ruffle
0.38	GO:0012505	endomembrane system
0.36	GO:0043227	membrane-bounded organelle
0.36	GO:0044422	organelle part
0.36	GO:0005886	plasma membrane

0.68

GO:0004674

sp|O14579|COPE_HUMAN
Coatomer subunit epsilon
Search

COPE

0.75	Coatomer protein complex subunit epsilon

0.80	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.60	GO:0015031	protein transport
0.47	GO:0006891	intra-Golgi vesicle-mediated transport
0.46	GO:0006888	ER to Golgi vesicle-mediated transport

0.61	GO:0005198	structural molecule activity
0.34	GO:0005515	protein binding

0.67	GO:0000139	Golgi membrane
0.67	GO:0031410	cytoplasmic vesicle
0.48	GO:0005654	nucleoplasm
0.46	GO:0012506	vesicle membrane
0.45	GO:0030117	membrane coat
0.45	GO:0098805	whole membrane
0.34	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0005829	cytosol
0.34	GO:0019028	viral capsid
0.30	GO:0031224	intrinsic component of membrane

sp|O14581|OR7AH_HUMAN
Olfactory receptor 7A17
Search

0.44	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O14593|RFXK_HUMAN
DNA-binding protein RFXANK
Search

RFXANK

0.95	Regulatory factor X subunit B

0.76	GO:0007265	Ras protein signal transduction
0.70	GO:0045944	positive regulation of transcription by RNA polymerase II

0.79	GO:0042826	histone deacetylase binding
0.56	GO:0003712	transcription cofactor activity

0.83	GO:0045171	intercellular bridge
0.68	GO:0005654	nucleoplasm
0.67	GO:0005829	cytosol

sp|O14594|NCAN_HUMAN
Neurocan core protein
Search

NCAN

0.92

Neurocan

0.70	GO:0007155	cell adhesion
0.48	GO:0001501	skeletal system development
0.47	GO:0007417	central nervous system development
0.42	GO:0030207	chondroitin sulfate catabolic process
0.42	GO:0030208	dermatan sulfate biosynthetic process
0.40	GO:0030206	chondroitin sulfate biosynthetic process
0.39	GO:0030198	extracellular matrix organization
0.32	GO:0051823	regulation of synapse structural plasticity

0.82	GO:0005540	hyaluronic acid binding
0.69	GO:0005509	calcium ion binding
0.49	GO:0005201	extracellular matrix structural constituent
0.40	GO:0030246	carbohydrate binding

0.47	GO:0005578	proteinaceous extracellular matrix
0.41	GO:0043202	lysosomal lumen
0.41	GO:0005796	Golgi lumen
0.31	GO:0005886	plasma membrane

sp|O14595|CTDS2_HUMAN
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Search

CTDSP2

0.97	Carboxy-terminal domain RNA polymerase II polypeptide A small

0.68	GO:0016311	dephosphorylation
0.54	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle
0.49	GO:0001933	negative regulation of protein phosphorylation
0.44	GO:0036211	protein modification process
0.42	GO:0044267	cellular protein metabolic process
0.41	GO:0030182	neuron differentiation
0.36	GO:0036498	IRE1-mediated unfolded protein response

0.69	GO:0016791	phosphatase activity
0.43	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.34	GO:0005634	nucleus
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.33	GO:0005794	Golgi apparatus
0.33	GO:0098588	bounding membrane of organelle
0.30	GO:0031224	intrinsic component of membrane

0.69

EC:3.1.3 EC:3.1.3.41

GO:0016791

sp|O14598|VCY1_HUMAN
Testis-specific basic protein Y 1
Search

0.97	Variable charge X-linked protein 3

0.79	GO:0007420	brain development
0.55	GO:0007283	spermatogenesis
0.53	GO:0042255	ribosome assembly
0.51	GO:0006325	chromatin organization

0.54

GO:0003682

chromatin binding

0.68

GO:0005730

nucleolus

sp|O14599|VCY2_HUMAN
Testis-specific basic protein Y 2
Search

BPY2

0.96	Testis-specific basic protein Y 2

0.83	GO:0007338	single fertilization
0.80	GO:0007283	spermatogenesis

0.90

GO:0032399

HECT domain binding

0.61

GO:0005634

nucleus

sp|O14602|IF1AY_HUMAN
Eukaryotic translation initiation factor 1A, Y-chromosomal
Search

0.83	Eukaryotic translation initiation factor 1A Y-linked

0.72	GO:0006413	translational initiation
0.37	GO:0000226	microtubule cytoskeleton organization
0.36	GO:0006468	protein phosphorylation
0.36	GO:0035556	intracellular signal transduction

0.73	GO:0003743	translation initiation factor activity
0.37	GO:0004674	protein serine/threonine kinase activity
0.36	GO:0000287	magnesium ion binding
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0043023	ribosomal large subunit binding
0.34	GO:0005515	protein binding

0.36	GO:0015630	microtubule cytoskeleton
0.33	GO:0005829	cytosol

0.37

GO:0004674

sp|O14603|PRY_HUMAN
PTPN13-like protein, Y-linked
Search

0.10	PTPN13-like protein, Y-linked

sp|O14604|TYB4Y_HUMAN
Thymosin beta-4, Y-chromosomal
Search

0.97	Thymosin beta 4 X-linked

0.75	GO:0007015	actin filament organization
0.49	GO:1905271	regulation of proton-transporting ATP synthase activity, rotational mechanism
0.48	GO:0042989	sequestering of actin monomers
0.47	GO:0007253	cytoplasmic sequestering of NF-kappaB
0.47	GO:2000483	negative regulation of interleukin-8 secretion
0.47	GO:2001171	positive regulation of ATP biosynthetic process
0.47	GO:1901223	negative regulation of NIK/NF-kappaB signaling
0.47	GO:2001028	positive regulation of endothelial cell chemotaxis
0.46	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
0.46	GO:0043536	positive regulation of blood vessel endothelial cell migration

0.85	GO:0003785	actin monomer binding
0.42	GO:0019899	enzyme binding
0.36	GO:0003727	single-stranded RNA binding
0.35	GO:0004888	transmembrane signaling receptor activity

0.44	GO:0005856	cytoskeleton
0.42	GO:0005829	cytosol
0.42	GO:0005576	extracellular region
0.40	GO:0005634	nucleus
0.35	GO:0031093	platelet alpha granule lumen
0.30	GO:0016020	membrane

sp|O14607|UTY_HUMAN
Histone demethylase UTY
Search

UTY

0.84	Ubiquitously transcribed tetratricopeptide repeat protein Y-linked transcript variant 5

0.85	GO:0071557	histone H3-K27 demethylation
0.56	GO:0060255	regulation of macromolecule metabolic process
0.38	GO:0032259	methylation
0.37	GO:0032525	somite rostral/caudal axis specification
0.37	GO:0003016	respiratory system process
0.37	GO:0048570	notochord morphogenesis
0.37	GO:0048333	mesodermal cell differentiation
0.36	GO:0001843	neural tube closure
0.36	GO:0035264	multicellular organism growth
0.36	GO:0060070	canonical Wnt signaling pathway

0.85	GO:0071558	histone demethylase activity (H3-K27 specific)
0.54	GO:0046872	metal ion binding
0.38	GO:0008168	methyltransferase activity
0.37	GO:0051213	dioxygenase activity
0.36	GO:0031490	chromatin DNA binding
0.36	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0042802	identical protein binding

0.37	GO:0005654	nucleoplasm
0.35	GO:0034708	methyltransferase complex

0.38

GO:0008168

sp|O14609|XKRY_HUMAN
Testis-specific XK-related protein, Y-linked
Search

0.92	Testis-specific XK-related protein, Y-linked

0.55

GO:0007338

single fertilization

0.39

GO:0005515

protein binding

0.37	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

sp|O14610|GBGT2_HUMAN
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Search

GNGT2

0.71	Guanine nucleotide-binding protein subunit gamma

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.47	GO:0042462	eye photoreceptor cell development
0.45	GO:0007602	phototransduction
0.41	GO:0008104	protein localization
0.38	GO:0010659	cardiac muscle cell apoptotic process
0.37	GO:0071456	cellular response to hypoxia
0.34	GO:0071377	cellular response to glucagon stimulus
0.34	GO:0022400	regulation of rhodopsin mediated signaling pathway
0.34	GO:0071482	cellular response to light stimulus
0.34	GO:0009584	detection of visible light

0.64	GO:0004871	signal transducer activity
0.44	GO:0003924	GTPase activity
0.33	GO:0005515	protein binding
0.33	GO:0003995	acyl-CoA dehydrogenase activity
0.33	GO:0050660	flavin adenine dinucleotide binding

0.81	GO:1905360	GTPase complex
0.80	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.66	GO:0098797	plasma membrane protein complex
0.37	GO:0001750	photoreceptor outer segment
0.37	GO:0001917	photoreceptor inner segment
0.36	GO:0060170	ciliary membrane

0.33

EC:1.3.99.3

GO:0003995

sp|O14613|BORG1_HUMAN
Cdc42 effector protein 2
Search

CDC42EP2

0.95	Binder of Rho GTPases 1

0.84	GO:0031274	positive regulation of pseudopodium assembly
0.74	GO:0030838	positive regulation of actin filament polymerization
0.74	GO:0071346	cellular response to interferon-gamma
0.70	GO:0043547	positive regulation of GTPase activity
0.66	GO:0007266	Rho protein signal transduction
0.65	GO:0010469	regulation of receptor activity
0.65	GO:0008360	regulation of cell shape
0.64	GO:0030036	actin cytoskeleton organization
0.39	GO:0071897	DNA biosynthetic process
0.38	GO:0006260	DNA replication

0.80	GO:0017049	GTP-Rho binding
0.79	GO:0001515	opioid peptide activity
0.71	GO:0005096	GTPase activator activity
0.39	GO:0003887	DNA-directed DNA polymerase activity
0.38	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.36	GO:0005509	calcium ion binding
0.36	GO:0003677	DNA binding
0.36	GO:0005519	cytoskeletal regulatory protein binding

0.72	GO:0045335	phagocytic vesicle
0.67	GO:0005856	cytoskeleton
0.60	GO:0005829	cytosol
0.55	GO:0005886	plasma membrane
0.43	GO:0012505	endomembrane system

0.39

GO:0003887

sp|O14617|AP3D1_HUMAN
AP-3 complex subunit delta-1
Search

AP3D1

0.72	AP-3 complex subunit delta

0.67	GO:0006886	intracellular protein transport
0.67	GO:0016192	vesicle-mediated transport
0.57	GO:0048499	synaptic vesicle membrane organization
0.56	GO:0048007	antigen processing and presentation, exogenous lipid antigen via MHC class Ib
0.56	GO:0051138	positive regulation of NK T cell differentiation
0.56	GO:0035646	endosome to melanosome transport
0.55	GO:0061088	regulation of sequestering of zinc ion
0.55	GO:0061462	protein localization to lysosome
0.54	GO:0008089	anterograde axonal transport
0.53	GO:0047496	vesicle transport along microtubule

0.33	GO:0005515	protein binding
0.33	GO:0005215	transporter activity

0.80	GO:0030123	AP-3 adaptor complex
0.57	GO:0098830	presynaptic endosome
0.54	GO:1904115	axon cytoplasm
0.54	GO:0043195	terminal bouton
0.51	GO:0005794	Golgi apparatus
0.51	GO:0010008	endosome membrane
0.41	GO:0005886	plasma membrane
0.37	GO:0005765	lysosomal membrane
0.36	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

sp|O14618|CCS_HUMAN
Copper chaperone for superoxide dismutase
Search

CCS

0.50	Copper chaperone for superoxide dismutase

0.75	GO:0006801	superoxide metabolic process
0.70	GO:0071451	cellular response to superoxide
0.65	GO:0030001	metal ion transport
0.64	GO:0098869	cellular oxidant detoxification
0.55	GO:0051353	positive regulation of oxidoreductase activity
0.51	GO:0055114	oxidation-reduction process
0.42	GO:0008340	determination of adult lifespan
0.41	GO:0050821	protein stabilization
0.34	GO:0046907	intracellular transport
0.32	GO:0034314	Arp2/3 complex-mediated actin nucleation

0.74	GO:0004784	superoxide dismutase activity
0.54	GO:0046872	metal ion binding
0.53	GO:0045296	cadherin binding
0.52	GO:0016530	metallochaperone activity
0.47	GO:0008047	enzyme activator activity
0.34	GO:0015035	protein disulfide oxidoreductase activity
0.34	GO:0019899	enzyme binding
0.32	GO:0043014	alpha-tubulin binding
0.32	GO:0003779	actin binding

0.44	GO:0005634	nucleus
0.44	GO:0005615	extracellular space
0.40	GO:0005737	cytoplasm
0.34	GO:0031970	organelle envelope lumen
0.32	GO:0019866	organelle inner membrane
0.32	GO:0097708	intracellular vesicle
0.32	GO:0012505	endomembrane system
0.31	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

0.74

EC:1.15.1.1

GO:0004784

sp|O14625|CXL11_HUMAN
C-X-C motif chemokine 11
Search

CXCL11

0.82	C-X-C motif chemokine

0.82	GO:0060326	cell chemotaxis
0.79	GO:0006954	inflammatory response
0.74	GO:0006955	immune response
0.73	GO:0010469	regulation of receptor activity
0.70	GO:0072678	T cell migration
0.68	GO:0043950	positive regulation of cAMP-mediated signaling
0.67	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
0.67	GO:0030816	positive regulation of cAMP metabolic process
0.66	GO:0070098	chemokine-mediated signaling pathway
0.61	GO:0042127	regulation of cell proliferation

0.84	GO:0008009	chemokine activity
0.72	GO:0048248	CXCR3 chemokine receptor binding
0.63	GO:0008201	heparin binding
0.36	GO:0042056	chemoattractant activity

0.71	GO:0005615	extracellular space
0.30	GO:0016020	membrane
0.30	GO:0005623	cell

sp|O14626|GP171_HUMAN
Probable G-protein coupled receptor 171
Search

GPR171

0.97	G protein-coupled receptor 171

0.72	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
0.57	GO:0045638	negative regulation of myeloid cell differentiation
0.57	GO:0007596	blood coagulation
0.48	GO:1904139	regulation of microglial cell migration
0.47	GO:0006930	substrate-dependent cell migration, cell extension
0.47	GO:0071318	cellular response to ATP
0.47	GO:0034109	homotypic cell-cell adhesion
0.46	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
0.46	GO:0001973	adenosine receptor signaling pathway
0.45	GO:0001775	cell activation

0.72	GO:0004930	G-protein coupled receptor activity
0.70	GO:0001614	purinergic nucleotide receptor activity
0.33	GO:0005085	guanyl-nucleotide exchange factor activity
0.32	GO:0008173	RNA methyltransferase activity

0.44	GO:0005887	integral component of plasma membrane
0.36	GO:0009925	basal plasma membrane
0.36	GO:0005901	caveola
0.36	GO:0009897	external side of plasma membrane
0.34	GO:0005739	mitochondrion
0.32	GO:0005783	endoplasmic reticulum
0.32	GO:0020002	host cell plasma membrane

0.32

GO:0008173

sp|O14627|CDX4_HUMAN
Homeobox protein CDX-4
Search

CDX4

0.94	Caudal-type homeobox protein CDXB

0.68	GO:0007275	multicellular organism development
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:0006366	transcription by RNA polymerase II
0.51	GO:0051254	positive regulation of RNA metabolic process
0.51	GO:0009653	anatomical structure morphogenesis
0.50	GO:0003006	developmental process involved in reproduction
0.50	GO:0010557	positive regulation of macromolecule biosynthetic process
0.50	GO:0031328	positive regulation of cellular biosynthetic process

0.62	GO:0043565	sequence-specific DNA binding
0.56	GO:0001012	RNA polymerase II regulatory region DNA binding
0.54	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.53	GO:0003690	double-stranded DNA binding
0.53	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.42	GO:0003682	chromatin binding
0.41	GO:0035326	enhancer binding
0.39	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.39	GO:0003714	transcription corepressor activity
0.37	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

0.61	GO:0005634	nucleus
0.39	GO:0017053	transcriptional repressor complex
0.38	GO:0000793	condensed chromosome
0.36	GO:0043233	organelle lumen
0.35	GO:0043234	protein complex
0.35	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:2.7.10.1

GO:0004714

sp|O14628|ZN195_HUMAN
Zinc finger protein 195
Search

0.76	Zinc finger protein 93

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.39	GO:0070895	negative regulation of transposon integration
0.38	GO:0006351	transcription, DNA-templated
0.37	GO:0035108	limb morphogenesis
0.36	GO:1902679	negative regulation of RNA biosynthetic process

0.52	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.40	GO:0003700	DNA binding transcription factor activity

0.44	GO:0005622	intracellular
0.39	GO:0043227	membrane-bounded organelle
0.37	GO:0043233	organelle lumen
0.34	GO:0043228	non-membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane

sp|O14633|LCE2B_HUMAN
Late cornified envelope protein 2B
Search

0.97	Late cornified envelope protein 2B

0.82	GO:0008544	epidermis development
0.69	GO:0018149	peptide cross-linking
0.68	GO:0043588	skin development
0.65	GO:0030855	epithelial cell differentiation
0.41	GO:0071277	cellular response to calcium ion
0.39	GO:0050890	cognition
0.37	GO:0012501	programmed cell death

0.53	GO:0005198	structural molecule activity
0.41	GO:0005515	protein binding

0.71	GO:0001533	cornified envelope
0.46	GO:0036338	viral membrane
0.44	GO:0005737	cytoplasm

sp|O14638|ENPP3_HUMAN
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Search

ENPP3

0.48	Ectonucleotide pyrophosphatase/phosphodiesterase 3

0.72	GO:0006955	immune response
0.70	GO:0006898	receptor-mediated endocytosis
0.54	GO:0009143	nucleoside triphosphate catabolic process
0.48	GO:0030505	inorganic diphosphate transport
0.45	GO:0030730	sequestering of triglyceride
0.45	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
0.45	GO:0045719	negative regulation of glycogen biosynthetic process
0.45	GO:0031953	negative regulation of protein autophosphorylation
0.44	GO:0046325	negative regulation of glucose import
0.44	GO:0046627	negative regulation of insulin receptor signaling pathway

0.79	GO:0005044	scavenger receptor activity
0.76	GO:0001871	pattern binding
0.68	GO:0030246	carbohydrate binding
0.53	GO:0046872	metal ion binding
0.52	GO:0047429	nucleoside-triphosphate diphosphatase activity
0.51	GO:0004528	phosphodiesterase I activity
0.50	GO:0003676	nucleic acid binding
0.47	GO:0004551	nucleotide diphosphatase activity
0.44	GO:0005158	insulin receptor binding
0.41	GO:0042803	protein homodimerization activity

0.51	GO:0048471	perinuclear region of cytoplasm
0.42	GO:0005576	extracellular region
0.42	GO:0009986	cell surface
0.37	GO:0005886	plasma membrane
0.36	GO:0031982	vesicle
0.35	GO:0005765	lysosomal membrane
0.30	GO:0016021	integral component of membrane

0.52

EC:3.6.1.19

GO:0047429

sp|O14639|ABLM1_HUMAN
Actin-binding LIM protein 1
Search

ABLIM1

0.79	Actin-binding LIM protein 1

0.69	GO:0007010	cytoskeleton organization
0.61	GO:0030032	lamellipodium assembly
0.56	GO:0060271	cilium assembly
0.38	GO:0009653	anatomical structure morphogenesis
0.38	GO:0048731	system development
0.37	GO:0007601	visual perception
0.36	GO:0045944	positive regulation of transcription by RNA polymerase II
0.36	GO:0048468	cell development
0.35	GO:0006935	chemotaxis
0.35	GO:0006928	movement of cell or subcellular component

0.71	GO:0003779	actin binding
0.52	GO:0046872	metal ion binding

0.60	GO:0097517	contractile actin filament bundle
0.59	GO:0042641	actomyosin
0.58	GO:0030027	lamellipodium
0.37	GO:0014069	postsynaptic density
0.33	GO:0005737	cytoplasm

sp|O14640|DVL1_HUMAN
Segment polarity protein dishevelled homolog DVL-1
Search

DVL1

0.97	Segment polarity protein dishevelled like protein DVL-1

0.75	GO:0016055	Wnt signaling pathway
0.61	GO:0035556	intracellular signal transduction
0.61	GO:0014022	neural plate elongation
0.60	GO:0090178	regulation of establishment of planar polarity involved in neural tube closure
0.60	GO:0071340	skeletal muscle acetylcholine-gated channel clustering
0.60	GO:0060134	prepulse inhibition
0.59	GO:0048668	collateral sprouting
0.59	GO:0060029	convergent extension involved in organogenesis
0.59	GO:0035372	protein localization to microtubule
0.59	GO:0090103	cochlea morphogenesis

0.58	GO:0005109	frizzled binding
0.56	GO:0008013	beta-catenin binding
0.53	GO:0019901	protein kinase binding
0.51	GO:0042802	identical protein binding
0.41	GO:0048365	Rac GTPase binding

0.60	GO:1990909	Wnt signalosome
0.56	GO:0016328	lateral plasma membrane
0.56	GO:0030426	growth cone
0.54	GO:0030424	axon
0.54	GO:0030136	clathrin-coated vesicle
0.54	GO:0098793	presynapse
0.50	GO:0015630	microtubule cytoskeleton
0.43	GO:0005829	cytosol
0.40	GO:0043197	dendritic spine
0.40	GO:0014069	postsynaptic density

sp|O14641|DVL2_HUMAN
Segment polarity protein dishevelled homolog DVL-2
Search

DVL2

0.97	Segment polarity protein dishevelled like protein DVL-2

0.77	GO:0016055	Wnt signaling pathway
0.62	GO:0035556	intracellular signal transduction
0.61	GO:0090178	regulation of establishment of planar polarity involved in neural tube closure
0.59	GO:0060026	convergent extension
0.59	GO:0043507	positive regulation of JUN kinase activity
0.59	GO:0001843	neural tube closure
0.58	GO:0014022	neural plate elongation
0.56	GO:0090103	cochlea morphogenesis
0.55	GO:0007379	segment specification
0.55	GO:0003151	outflow tract morphogenesis

0.62	GO:0005109	frizzled binding
0.59	GO:0048365	Rac GTPase binding
0.54	GO:0043621	protein self-association
0.52	GO:0030674	protein binding, bridging
0.51	GO:0019901	protein kinase binding
0.50	GO:0019904	protein domain specific binding
0.49	GO:0042802	identical protein binding
0.45	GO:0008013	beta-catenin binding
0.44	GO:0002020	protease binding
0.42	GO:0046982	protein heterodimerization activity

0.55	GO:0016235	aggresome
0.54	GO:0016328	lateral plasma membrane
0.52	GO:0045177	apical part of cell
0.52	GO:0016604	nuclear body
0.52	GO:0030136	clathrin-coated vesicle
0.51	GO:0005829	cytosol
0.43	GO:0005938	cell cortex
0.42	GO:0005819	spindle
0.42	GO:0000790	nuclear chromatin
0.37	GO:0035253	ciliary rootlet

0.33

EC:2.7.7

GO:0016779

sp|O14645|IDLC_HUMAN
Axonemal dynein light intermediate polypeptide 1
Search

DNALI1

0.95	LOW QUALITY PROTEIN: axonemal dynein light intermediate polypeptide 1

0.39

GO:0003341

cilium movement

0.85	GO:0045504	dynein heavy chain binding
0.45	GO:0003774	motor activity

0.82	GO:0030175	filopodium
0.79	GO:0005930	axoneme
0.47	GO:0030286	dynein complex
0.30	GO:0044425	membrane part

sp|O14646|CHD1_HUMAN
Chromodomain-helicase-DNA-binding protein 1
Search

CHD1

0.86	Z-linked chromodomain helicase DNA binding protein 1

0.59	GO:0043923	positive regulation by host of viral transcription
0.51	GO:0016569	covalent chromatin modification
0.48	GO:0006338	chromatin remodeling
0.35	GO:0006333	chromatin assembly or disassembly
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression
0.34	GO:0032392	DNA geometric change
0.34	GO:0000165	MAPK cascade

0.56	GO:0140034	methylation-dependent protein binding
0.55	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0042393	histone binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0003677	DNA binding
0.35	GO:0003682	chromatin binding
0.34	GO:0008094	DNA-dependent ATPase activity
0.34	GO:0004707	MAP kinase activity

0.60	GO:0005634	nucleus
0.48	GO:0031974	membrane-enclosed lumen
0.44	GO:0043232	intracellular non-membrane-bounded organelle
0.43	GO:0044446	intracellular organelle part
0.39	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.34	EC:2.7.11.24	GO:0004707
0.34	KEGG:R00162	GO:0004707

sp|O14647|CHD2_HUMAN
Chromodomain-helicase-DNA-binding protein 2
Search

CHD2

0.83	Chromodomain-helicase-DNA-binding protein 2

0.46	GO:0060218	hematopoietic stem cell differentiation
0.44	GO:0007517	muscle organ development
0.40	GO:0006974	cellular response to DNA damage stimulus
0.38	GO:0016569	covalent chromatin modification
0.35	GO:0006357	regulation of transcription by RNA polymerase II
0.35	GO:0032392	DNA geometric change
0.35	GO:0006351	transcription, DNA-templated

0.67	GO:0004386	helicase activity
0.55	GO:0003677	DNA binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0042393	histone binding
0.43	GO:0001067	regulatory region nucleic acid binding
0.35	GO:0008094	DNA-dependent ATPase activity
0.34	GO:0140097	catalytic activity, acting on DNA
0.34	GO:0003723	RNA binding

0.61	GO:0005634	nucleus
0.40	GO:0031974	membrane-enclosed lumen
0.38	GO:0043232	intracellular non-membrane-bounded organelle
0.38	GO:0044446	intracellular organelle part
0.37	GO:0070062	extracellular exosome

sp|O14649|KCNK3_HUMAN
Potassium channel subfamily K member 3
Search

KCNK3

0.93	Potassium two pore domain channel subfamily K member 3

0.72	GO:0071805	potassium ion transmembrane transport
0.66	GO:0010469	regulation of receptor activity
0.53	GO:0030322	stabilization of membrane potential
0.47	GO:0060047	heart contraction
0.40	GO:0051481	negative regulation of cytosolic calcium ion concentration
0.40	GO:0071294	cellular response to zinc ion
0.39	GO:0090102	cochlea development
0.39	GO:0071456	cellular response to hypoxia
0.38	GO:0007420	brain development
0.37	GO:0042493	response to drug

0.79	GO:0005252	open rectifier potassium channel activity
0.68	GO:0008083	growth factor activity
0.59	GO:0022841	potassium ion leak channel activity
0.54	GO:0044548	S100 protein binding
0.39	GO:0042803	protein homodimerization activity
0.39	GO:0046982	protein heterodimerization activity
0.39	GO:0008022	protein C-terminus binding

0.64	GO:0005615	extracellular space
0.45	GO:0005887	integral component of plasma membrane
0.36	GO:0008021	synaptic vesicle

sp|O14653|GOSR2_HUMAN
Golgi SNAP receptor complex member 2
Search

GOSR2

0.92	Golgi SNAP receptor complex member 2

0.67	GO:0016192	vesicle-mediated transport
0.67	GO:0061025	membrane fusion
0.54	GO:0015031	protein transport
0.42	GO:0072666	establishment of protein localization to vacuole
0.42	GO:0048284	organelle fusion
0.42	GO:0016482	cytosolic transport
0.42	GO:0016050	vesicle organization
0.41	GO:0007034	vacuolar transport
0.41	GO:0016197	endosomal transport
0.37	GO:0036498	IRE1-mediated unfolded protein response

0.79	GO:0005484	SNAP receptor activity
0.42	GO:0000149	SNARE binding

0.69	GO:0005794	Golgi apparatus
0.42	GO:0031902	late endosome membrane
0.42	GO:0031201	SNARE complex
0.42	GO:0012507	ER to Golgi transport vesicle membrane
0.42	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0005829	cytosol
0.36	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
0.30	GO:0016021	integral component of membrane

sp|O14654|IRS4_HUMAN
Insulin receptor substrate 4
Search

IRS4

0.97	LOW QUALITY PROTEIN: insulin receptor substrate 4

0.84	GO:0008286	insulin receptor signaling pathway
0.78	GO:0019216	regulation of lipid metabolic process
0.66	GO:0048009	insulin-like growth factor receptor signaling pathway
0.66	GO:0045725	positive regulation of glycogen biosynthetic process
0.65	GO:2001275	positive regulation of glucose import in response to insulin stimulus
0.64	GO:0046676	negative regulation of insulin secretion
0.63	GO:0014065	phosphatidylinositol 3-kinase signaling
0.60	GO:0010565	regulation of cellular ketone metabolic process
0.58	GO:0031331	positive regulation of cellular catabolic process
0.51	GO:0023056	positive regulation of signaling

0.85	GO:0043548	phosphatidylinositol 3-kinase binding
0.85	GO:0005158	insulin receptor binding
0.65	GO:0005159	insulin-like growth factor receptor binding
0.63	GO:0001784	phosphotyrosine residue binding
0.60	GO:0004871	signal transducer activity
0.54	GO:0035591	signaling adaptor activity
0.52	GO:0030674	protein binding, bridging
0.45	GO:0042169	SH2 domain binding
0.41	GO:0019901	protein kinase binding
0.38	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity

0.68	GO:0005829	cytosol
0.61	GO:0005901	caveola
0.49	GO:0005634	nucleus
0.41	GO:0005899	insulin receptor complex
0.39	GO:0036064	ciliary basal body
0.34	GO:0043234	protein complex

0.38	EC:2.7.1.153	GO:0046934
0.38	KEGG:R04545	GO:0046934

sp|O14656|TOR1A_HUMAN
Torsin-1A
Search

TOR1A

0.97	Torsin family 1 member A

0.79	GO:0006998	nuclear envelope organization
0.79	GO:0072321	chaperone-mediated protein transport
0.76	GO:0061077	chaperone-mediated protein folding
0.76	GO:0045104	intermediate filament cytoskeleton organization
0.74	GO:0051084	'de novo' posttranslational protein folding
0.73	GO:0048489	synaptic vesicle transport
0.69	GO:0031175	neuron projection development
0.64	GO:0007155	cell adhesion
0.61	GO:0007029	endoplasmic reticulum organization
0.59	GO:1900244	positive regulation of synaptic vesicle endocytosis

0.64	GO:0008092	cytoskeletal protein binding
0.64	GO:0051082	unfolded protein binding
0.56	GO:0051787	misfolded protein binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0016887	ATPase activity

0.80	GO:0005788	endoplasmic reticulum lumen
0.71	GO:0005635	nuclear envelope
0.67	GO:0045202	synapse
0.57	GO:0042406	extrinsic component of endoplasmic reticulum membrane
0.53	GO:0070382	exocytic vesicle
0.51	GO:0097458	neuron part
0.40	GO:0030141	secretory granule
0.40	GO:0030427	site of polarized growth
0.40	GO:0030659	cytoplasmic vesicle membrane
0.39	GO:0120038	plasma membrane bounded cell projection part

0.48

GO:0016887

sp|O14657|TOR1B_HUMAN
Torsin-1B
Search

TOR1B

0.97	Torsin family 1 member B

0.79	GO:0010256	endomembrane system organization
0.75	GO:0051085	chaperone cofactor-dependent protein refolding
0.72	GO:0006997	nucleus organization
0.71	GO:0072321	chaperone-mediated protein transport
0.68	GO:0045104	intermediate filament cytoskeleton organization
0.66	GO:0048489	synaptic vesicle transport
0.63	GO:0031175	neuron projection development
0.60	GO:0061024	membrane organization
0.59	GO:0051260	protein homooligomerization
0.59	GO:0007155	cell adhesion

0.58	GO:0008092	cytoskeletal protein binding
0.58	GO:0051082	unfolded protein binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0051787	misfolded protein binding
0.48	GO:0016887	ATPase activity

0.78	GO:0005788	endoplasmic reticulum lumen
0.67	GO:0005635	nuclear envelope
0.61	GO:0045202	synapse
0.54	GO:0042406	extrinsic component of endoplasmic reticulum membrane
0.51	GO:0070382	exocytic vesicle
0.48	GO:0097458	neuron part
0.39	GO:0030141	secretory granule
0.39	GO:0030427	site of polarized growth
0.38	GO:0030659	cytoplasmic vesicle membrane
0.38	GO:0070062	extracellular exosome

0.48

GO:0016887

sp|O14662|STX16_HUMAN
Syntaxin-16
Search

STX16

0.92	STX16-NPEPL1 readthrough (NMD candidate)

0.69	GO:0006886	intracellular protein transport
0.69	GO:0016192	vesicle-mediated transport
0.67	GO:0061025	membrane fusion
0.45	GO:0048284	organelle fusion
0.45	GO:0016050	vesicle organization
0.45	GO:0140056	organelle localization by membrane tethering
0.45	GO:0090161	Golgi ribbon formation
0.44	GO:0039023	pronephric duct morphogenesis
0.42	GO:0016482	cytosolic transport
0.42	GO:0016197	endosomal transport

0.79	GO:0005484	SNAP receptor activity
0.48	GO:0000149	SNARE binding
0.38	GO:0004177	aminopeptidase activity
0.38	GO:0008235	metalloexopeptidase activity
0.38	GO:0030145	manganese ion binding

0.82	GO:0031201	SNARE complex
0.48	GO:0005794	Golgi apparatus
0.42	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0005829	cytosol
0.39	GO:0031984	organelle subcompartment
0.37	GO:0005925	focal adhesion
0.36	GO:0005783	endoplasmic reticulum
0.35	GO:0098588	bounding membrane of organelle
0.30	GO:0016021	integral component of membrane

0.38

EC:3.4.11

GO:0004177

sp|O14668|TMG1_HUMAN
Transmembrane gamma-carboxyglutamic acid protein 1
Search

PRRG1

0.66	Transmembrane gamma-carboxyglutamic acid protein 1

0.43	GO:0007596	blood coagulation
0.38	GO:0006508	proteolysis
0.36	GO:0051897	positive regulation of protein kinase B signaling
0.34	GO:0018108	peptidyl-tyrosine phosphorylation
0.33	GO:0006879	cellular iron ion homeostasis
0.33	GO:0006826	iron ion transport
0.33	GO:0010952	positive regulation of peptidase activity
0.33	GO:0007154	cell communication
0.32	GO:0009405	pathogenesis
0.32	GO:0023052	signaling

0.69	GO:0005509	calcium ion binding
0.40	GO:0004252	serine-type endopeptidase activity
0.35	GO:0005543	phospholipid binding
0.34	GO:0004713	protein tyrosine kinase activity
0.33	GO:0008199	ferric iron binding
0.33	GO:0016504	peptidase activator activity
0.33	GO:0090729	toxin activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.65	GO:0005576	extracellular region
0.35	GO:0005887	integral component of plasma membrane

0.40

GO:0004252

sp|O14669|TMG2_HUMAN
Transmembrane gamma-carboxyglutamic acid protein 2
Search

PRRG2

0.94	Transmembrane gamma-carboxyglutamic acid protein 2

0.58	GO:0007596	blood coagulation
0.50	GO:0006508	proteolysis
0.46	GO:0006953	acute-phase response
0.40	GO:0030195	negative regulation of blood coagulation
0.39	GO:0051838	cytolysis by host of symbiont cells
0.39	GO:0070945	neutrophil mediated killing of gram-negative bacterium
0.39	GO:1900738	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
0.39	GO:1902533	positive regulation of intracellular signal transduction
0.39	GO:1900016	negative regulation of cytokine production involved in inflammatory response
0.39	GO:0048712	negative regulation of astrocyte differentiation

0.70	GO:0005509	calcium ion binding
0.55	GO:0004252	serine-type endopeptidase activity
0.39	GO:0070053	thrombospondin receptor activity
0.38	GO:0005515	protein binding
0.38	GO:0008289	lipid binding
0.38	GO:0008201	heparin binding
0.32	GO:0044877	macromolecular complex binding
0.32	GO:0008061	chitin binding
0.32	GO:0003743	translation initiation factor activity

0.66	GO:0005576	extracellular region
0.43	GO:0005887	integral component of plasma membrane
0.37	GO:0009897	external side of plasma membrane

0.55

GO:0004252

sp|O14672|ADA10_HUMAN
Disintegrin and metalloproteinase domain-containing protein 10
Search

ADAM10

0.92	Disintegrin and metalloproteinase domain-containing protein 10

0.85	GO:0006509	membrane protein ectodomain proteolysis
0.82	GO:0007219	Notch signaling pathway
0.66	GO:0007229	integrin-mediated signaling pathway
0.56	GO:0042117	monocyte activation
0.55	GO:0010820	positive regulation of T cell chemotaxis
0.52	GO:0007162	negative regulation of cell adhesion
0.52	GO:0034612	response to tumor necrosis factor
0.52	GO:0030307	positive regulation of cell growth
0.50	GO:0008284	positive regulation of cell proliferation
0.50	GO:0001701	in utero embryonic development

0.70	GO:0004222	metalloendopeptidase activity
0.53	GO:0046872	metal ion binding
0.51	GO:0019901	protein kinase binding
0.50	GO:0042803	protein homodimerization activity
0.39	GO:0017124	SH3 domain binding
0.35	GO:0042169	SH2 domain binding
0.35	GO:0005178	integrin binding

0.55	GO:0097197	tetraspanin-enriched microdomain
0.53	GO:0097038	perinuclear endoplasmic reticulum
0.53	GO:0014069	postsynaptic density
0.50	GO:0005798	Golgi-associated vesicle
0.49	GO:0009986	cell surface
0.48	GO:0005615	extracellular space
0.48	GO:0005794	Golgi apparatus
0.44	GO:0005634	nucleus
0.36	GO:0098588	bounding membrane of organelle
0.36	GO:0031984	organelle subcompartment

0.70

GO:0004222

sp|O14678|ABCD4_HUMAN
ATP-binding cassette sub-family D member 4
Search

ABCD4

0.95	ATP-binding cassette sub-family D member 4

0.57	GO:1990830	cellular response to leukemia inhibitory factor
0.55	GO:0055085	transmembrane transport
0.51	GO:0009235	cobalamin metabolic process

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.53	GO:0042579	microbody
0.51	GO:0005789	endoplasmic reticulum membrane
0.35	GO:0005765	lysosomal membrane
0.34	GO:0043190	ATP-binding cassette (ABC) transporter complex

sp|O14681|EI24_HUMAN
Etoposide-induced protein 2.4 homolog
Search

EI24

0.94	STT3A, subunit of the oligosaccharyltransferase complex (catalytic)

0.54	GO:0030308	negative regulation of cell growth
0.46	GO:0016236	macroautophagy
0.45	GO:0006915	apoptotic process
0.38	GO:0071494	cellular response to UV-C
0.37	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
0.37	GO:0050885	neuromuscular process controlling balance
0.37	GO:0042308	negative regulation of protein import into nucleus
0.36	GO:0006486	protein glycosylation
0.35	GO:0042493	response to drug
0.34	GO:0006974	cellular response to DNA damage stimulus

0.37	GO:0004576	oligosaccharyl transferase activity
0.35	GO:0061676	importin-alpha family protein binding

0.50	GO:0005783	endoplasmic reticulum
0.49	GO:0005794	Golgi apparatus
0.47	GO:0005829	cytosol
0.37	GO:0031965	nuclear membrane
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.37

GO:0004576

sp|O14682|ENC1_HUMAN
Ectoderm-neural cortex protein 1
Search

ENC1

0.78	Ectodermal-neural cortex

0.74	GO:0007399	nervous system development
0.57	GO:0010499	proteasomal ubiquitin-independent protein catabolic process
0.53	GO:0017148	negative regulation of translation
0.51	GO:0016567	protein ubiquitination
0.39	GO:0031346	positive regulation of cell projection organization
0.39	GO:0010720	positive regulation of cell development
0.39	GO:0051962	positive regulation of nervous system development
0.39	GO:0120035	regulation of plasma membrane bounded cell projection organization
0.37	GO:0030154	cell differentiation

0.73

GO:0003779

actin binding

0.56	GO:0031463	Cul3-RING ubiquitin ligase complex
0.39	GO:0016363	nuclear matrix
0.39	GO:0005737	cytoplasm
0.39	GO:0043025	neuronal cell body
0.38	GO:0000790	nuclear chromatin
0.37	GO:0005730	nucleolus
0.37	GO:0005654	nucleoplasm
0.35	GO:0005856	cytoskeleton

sp|O14683|P5I11_HUMAN
Tumor protein p53-inducible protein 11
Search

TP53I11

0.67	Tumor protein p53-inducible protein 11

0.35	GO:0008285	negative regulation of cell proliferation
0.34	GO:0006334	nucleosome assembly

0.32

GO:0003677

DNA binding

0.33	GO:0000786	nucleosome
0.30	GO:0044425	membrane part

sp|O14684|PTGES_HUMAN
Prostaglandin E synthase
Search

PTGES

0.97	Inducible prostaglandin E synthase

0.57	GO:0046457	prostanoid biosynthetic process
0.57	GO:0006693	prostaglandin metabolic process
0.52	GO:0008285	negative regulation of cell proliferation
0.43	GO:0042074	cell migration involved in gastrulation
0.39	GO:0002544	chronic inflammatory response
0.38	GO:0002526	acute inflammatory response
0.38	GO:0032526	response to retinoic acid
0.38	GO:0034097	response to cytokine
0.38	GO:0051592	response to calcium ion
0.38	GO:0032496	response to lipopolysaccharide

0.61	GO:0050220	prostaglandin-E synthase activity
0.57	GO:0043295	glutathione binding
0.36	GO:0016740	transferase activity
0.35	GO:0004667	prostaglandin-D synthase activity
0.33	GO:0004602	glutathione peroxidase activity
0.32	GO:0004984	olfactory receptor activity
0.32	GO:0004930	G-protein coupled receptor activity

0.56	GO:0005641	nuclear envelope lumen
0.39	GO:0005737	cytoplasm
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.34	GO:0031984	organelle subcompartment
0.31	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.61	EC:5.3.99.3	GO:0050220
0.61	KEGG:R02265	GO:0050220

sp|O14686|KMT2D_HUMAN
Histone-lysine N-methyltransferase 2D
Search

KMT2D

0.47	Histone-lysine N-methyltransferase

0.83	GO:0051568	histone H3-K4 methylation
0.66	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
0.64	GO:0043627	response to estrogen
0.59	GO:0008284	positive regulation of cell proliferation
0.57	GO:0045944	positive regulation of transcription by RNA polymerase II
0.44	GO:0001555	oocyte growth
0.41	GO:0006342	chromatin silencing
0.41	GO:1904837	beta-catenin-TCF complex assembly
0.40	GO:0045652	regulation of megakaryocyte differentiation
0.39	GO:0043009	chordate embryonic development

0.84	GO:0042800	histone methyltransferase activity (H3-K4 specific)
0.57	GO:0044212	transcription regulatory region DNA binding
0.53	GO:0046872	metal ion binding
0.37	GO:0005515	protein binding
0.35	GO:0003924	GTPase activity
0.35	GO:0032550	purine ribonucleoside binding
0.35	GO:0019001	guanyl nucleotide binding
0.35	GO:0003700	DNA binding transcription factor activity
0.34	GO:0008233	peptidase activity
0.34	GO:0032555	purine ribonucleotide binding

0.79	GO:0035097	histone methyltransferase complex
0.35	GO:0005615	extracellular space
0.33	GO:0005886	plasma membrane
0.33	GO:0005874	microtubule
0.32	GO:0005737	cytoplasm

0.34

GO:0008233

sp|O14709|ZN197_HUMAN
Zinc finger protein 197
Search

ZNF197

0.73	Zinc finger protein 197

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:0006351	transcription, DNA-templated
0.35	GO:0007219	Notch signaling pathway
0.34	GO:1902679	negative regulation of RNA biosynthetic process

0.59	GO:0003700	DNA binding transcription factor activity
0.51	GO:0046872	metal ion binding
0.50	GO:0003676	nucleic acid binding
0.35	GO:0003682	chromatin binding
0.32	GO:0005515	protein binding

0.58	GO:0005634	nucleus
0.35	GO:0070062	extracellular exosome

sp|O14713|ITBP1_HUMAN
Integrin beta-1-binding protein 1
Search

ITGB1BP1

0.97	Integrin subunit beta 1 binding protein 1

0.78	GO:0007229	integrin-mediated signaling pathway
0.64	GO:0090315	negative regulation of protein targeting to membrane
0.63	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis
0.63	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration
0.62	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
0.62	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
0.62	GO:0051895	negative regulation of focal adhesion assembly
0.62	GO:0010764	negative regulation of fibroblast migration
0.62	GO:0032148	activation of protein kinase B activity
0.61	GO:0033622	integrin activation

0.59	GO:0005178	integrin binding
0.58	GO:0005092	GDP-dissociation inhibitor activity
0.55	GO:0019901	protein kinase binding
0.52	GO:0008565	protein transporter activity
0.35	GO:0008022	protein C-terminus binding

0.59	GO:0001726	ruffle
0.58	GO:0030027	lamellipodium
0.56	GO:0048471	perinuclear region of cytoplasm
0.56	GO:0016604	nuclear body
0.54	GO:0005815	microtubule organizing center
0.52	GO:0005829	cytosol
0.43	GO:0071944	cell periphery
0.41	GO:0005925	focal adhesion
0.37	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

sp|O14715|RGPD8_HUMAN
RANBP2-like and GRIP domain-containing protein 8
Search

0.93	RANBP2-like and GRIP domain-containing protein 8

0.69	GO:0046907	intracellular transport
0.48	GO:0046604	positive regulation of mitotic centrosome separation
0.45	GO:0000082	G1/S transition of mitotic cell cycle
0.45	GO:0000413	protein peptidyl-prolyl isomerization
0.45	GO:0006606	protein import into nucleus
0.45	GO:0007051	spindle organization
0.43	GO:0043547	positive regulation of GTPase activity
0.43	GO:0006405	RNA export from nucleus
0.43	GO:0006511	ubiquitin-dependent protein catabolic process

0.51	GO:0008536	Ran GTPase binding
0.45	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.43	GO:0005096	GTPase activator activity
0.39	GO:0046872	metal ion binding

0.45	GO:0005622	intracellular
0.41	GO:0044422	organelle part
0.41	GO:0012505	endomembrane system
0.41	GO:0043227	membrane-bounded organelle
0.39	GO:0031975	envelope
0.39	GO:0043234	protein complex
0.38	GO:0043228	non-membrane-bounded organelle

0.45

GO:0003755

sp|O14717|TRDMT_HUMAN
tRNA (cytosine(38)-C(5))-methyltransferase
Search

TRDMT1

0.91	tRNA aspartic acid methyltransferase 1

0.63	GO:0032259	methylation
0.49	GO:0006400	tRNA modification
0.42	GO:0001975	response to amphetamine
0.39	GO:0044260	cellular macromolecule metabolic process
0.33	GO:0006546	glycine catabolic process
0.32	GO:0055114	oxidation-reduction process

0.63	GO:0008168	methyltransferase activity
0.47	GO:0140101	catalytic activity, acting on a tRNA
0.35	GO:0003723	RNA binding
0.34	GO:0005509	calcium ion binding
0.33	GO:0016642	oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor

0.39	GO:0005737	cytoplasm
0.36	GO:0005634	nucleus
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.63

GO:0008168

sp|O14718|OPSX_HUMAN
Visual pigment-like receptor peropsin
Search

RRH

0.92	Visual pigment-like receptor peropsin

0.78	GO:0007601	visual perception
0.74	GO:0018298	protein-chromophore linkage
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.40	GO:0009584	detection of visible light
0.40	GO:0007602	phototransduction
0.38	GO:0001522	pseudouridine synthesis
0.37	GO:0042254	ribosome biogenesis

0.78	GO:0009881	photoreceptor activity
0.72	GO:0004930	G-protein coupled receptor activity

0.41	GO:0001750	photoreceptor outer segment
0.40	GO:0031429	box H/ACA snoRNP complex
0.36	GO:0005887	integral component of plasma membrane

sp|O14727|APAF_HUMAN
Apoptotic protease-activating factor 1
Search

APAF1

0.94	Apoptotic peptidase activating factor 1

0.77	GO:0097190	apoptotic signaling pathway
0.73	GO:0042981	regulation of apoptotic process
0.64	GO:1903624	regulation of DNA catabolic process
0.61	GO:0051402	neuron apoptotic process
0.61	GO:2001056	positive regulation of cysteine-type endopeptidase activity
0.60	GO:0001843	neural tube closure
0.58	GO:0030900	forebrain development
0.58	GO:0043068	positive regulation of programmed cell death
0.57	GO:0034976	response to endoplasmic reticulum stress
0.55	GO:0009967	positive regulation of signal transduction

0.75	GO:0043531	ADP binding
0.65	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
0.54	GO:0042802	identical protein binding
0.52	GO:0008233	peptidase activity
0.51	GO:0005524	ATP binding
0.38	GO:0031072	heat shock protein binding

0.85	GO:0043293	apoptosome
0.47	GO:0005634	nucleus
0.37	GO:0070062	extracellular exosome
0.37	GO:1904813	ficolin-1-rich granule lumen
0.36	GO:0034774	secretory granule lumen

0.52

GO:0008233

sp|O14730|RIOK3_HUMAN
Serine/threonine-protein kinase RIO3
Search

RIOK3

0.94	Serine/threonine-protein kinase RIO3

0.63	GO:0006468	protein phosphorylation
0.60	GO:1990786	cellular response to dsDNA
0.58	GO:0039534	negative regulation of MDA-5 signaling pathway
0.58	GO:0032463	negative regulation of protein homooligomerization
0.56	GO:0032728	positive regulation of interferon-beta production
0.55	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
0.55	GO:0098586	cellular response to virus
0.54	GO:0071359	cellular response to dsRNA
0.53	GO:0045089	positive regulation of innate immune response
0.52	GO:0030490	maturation of SSU-rRNA

0.70	GO:0004674	protein serine/threonine kinase activity
0.58	GO:0089720	caspase binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0046872	metal ion binding

0.54	GO:0030688	preribosome, small subunit precursor
0.34	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.70

GO:0004674

sp|O14732|IMPA2_HUMAN
Inositol monophosphatase 2
Search

IMPA2

0.41	Inositol monophosphatase 2

0.80	GO:0006021	inositol biosynthetic process
0.79	GO:0046855	inositol phosphate dephosphorylation
0.75	GO:0046854	phosphatidylinositol phosphorylation
0.41	GO:0007165	signal transduction
0.34	GO:0006915	apoptotic process
0.34	GO:0006661	phosphatidylinositol biosynthetic process
0.33	GO:0019915	lipid storage

0.79	GO:0008934	inositol monophosphate 1-phosphatase activity
0.78	GO:0052832	inositol monophosphate 3-phosphatase activity
0.78	GO:0052833	inositol monophosphate 4-phosphatase activity
0.53	GO:0046872	metal ion binding
0.51	GO:0042803	protein homodimerization activity

0.39	GO:0005737	cytoplasm
0.33	GO:0005811	lipid droplet
0.30	GO:0016020	membrane

0.79

EC:3.1.3.25

GO:0008934

sp|O14733|MP2K7_HUMAN
Dual specificity mitogen-activated protein kinase kinase 7
Search

MAP2K7

0.97	Dual specificity mitogen-activated protein kinase kinase 7

0.63	GO:0006468	protein phosphorylation
0.54	GO:0031098	stress-activated protein kinase signaling cascade
0.53	GO:1904355	positive regulation of telomere capping
0.53	GO:0051973	positive regulation of telomerase activity
0.52	GO:0032212	positive regulation of telomere maintenance via telomerase
0.52	GO:0032147	activation of protein kinase activity
0.51	GO:0034612	response to tumor necrosis factor
0.50	GO:0043406	positive regulation of MAP kinase activity
0.50	GO:0009411	response to UV
0.50	GO:0006970	response to osmotic stress

0.64	GO:0004672	protein kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0019901	protein kinase binding
0.44	GO:0000287	magnesium ion binding
0.43	GO:0004871	signal transducer activity
0.38	GO:0019903	protein phosphatase binding
0.35	GO:0008022	protein C-terminus binding

0.37	GO:0005622	intracellular
0.34	GO:0043227	membrane-bounded organelle
0.33	GO:0030424	axon
0.33	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

sp|O14734|ACOT8_HUMAN
Acyl-coenzyme A thioesterase 8
Search

ACOT8

0.87	Acyl-coenzyme A thioesterase 8

0.73	GO:0035383	thioester metabolic process
0.63	GO:0006732	coenzyme metabolic process
0.62	GO:0045225	negative regulation of CD4 biosynthetic process
0.56	GO:0016559	peroxisome fission
0.54	GO:0043649	dicarboxylic acid catabolic process
0.54	GO:0006793	phosphorus metabolic process
0.46	GO:0009062	fatty acid catabolic process
0.36	GO:0036109	alpha-linolenic acid metabolic process
0.36	GO:0006699	bile acid biosynthetic process
0.35	GO:0019395	fatty acid oxidation

0.81	GO:0047617	acyl-CoA hydrolase activity
0.51	GO:0005102	receptor binding
0.41	GO:0033882	choloyl-CoA hydrolase activity
0.36	GO:0052689	carboxylic ester hydrolase activity
0.36	GO:0003986	acetyl-CoA hydrolase activity
0.35	GO:0102991	myristoyl-CoA hydrolase activity
0.34	GO:0016853	isomerase activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0046982	protein heterodimerization activity
0.33	GO:0030234	enzyme regulator activity

0.59	GO:0031907	microbody lumen
0.56	GO:0044439	peroxisomal part
0.45	GO:0005739	mitochondrion
0.32	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.81	EC:3.1.2 EC:3.1.2.20	GO:0047617
0.36	KEGG:R00630	GO:0052689

sp|O14735|CDIPT_HUMAN
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Search

CDIPT

0.67	CDP-diacylglycerol--inositol 3-phosphatidyltransferase

0.67	GO:0008654	phospholipid biosynthetic process
0.53	GO:0046488	phosphatidylinositol metabolic process
0.52	GO:0045017	glycerolipid biosynthetic process
0.44	GO:0071788	endoplasmic reticulum tubular network maintenance
0.44	GO:0072576	liver morphogenesis
0.44	GO:0060729	intestinal epithelial structure maintenance
0.43	GO:0060219	camera-type eye photoreceptor cell differentiation
0.43	GO:0010842	retina layer formation
0.42	GO:0002088	lens development in camera-type eye
0.41	GO:0034976	response to endoplasmic reticulum stress

0.80	GO:0003881	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
0.40	GO:0019992	diacylglycerol binding
0.39	GO:0043178	alcohol binding
0.38	GO:0030145	manganese ion binding
0.37	GO:0030246	carbohydrate binding
0.34	GO:0008236	serine-type peptidase activity
0.33	GO:0003676	nucleic acid binding
0.33	GO:0005515	protein binding

0.66	GO:0005794	Golgi apparatus
0.37	GO:0098588	bounding membrane of organelle
0.36	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0005886	plasma membrane
0.34	GO:0098805	whole membrane
0.33	GO:0019867	outer membrane
0.33	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.80	EC:2.7.8.11	GO:0003881
0.80	KEGG:R01802	GO:0003881

sp|O14737|PDCD5_HUMAN
Programmed cell death protein 5
Search

PDCD5

0.94	Programmed cell death protein 5

0.57	GO:1903645	negative regulation of chaperone-mediated protein folding
0.57	GO:1903638	positive regulation of protein import into mitochondrial outer membrane
0.54	GO:0090200	positive regulation of release of cytochrome c from mitochondria
0.52	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.51	GO:0071560	cellular response to transforming growth factor beta stimulus
0.50	GO:0008285	negative regulation of cell proliferation
0.47	GO:0010628	positive regulation of gene expression
0.47	GO:0012501	programmed cell death
0.33	GO:0071805	potassium ion transmembrane transport
0.32	GO:0019538	protein metabolic process

0.55	GO:0010698	acetyltransferase activator activity
0.55	GO:0003677	DNA binding
0.52	GO:0048487	beta-tubulin binding
0.51	GO:0008201	heparin binding
0.33	GO:0005267	potassium channel activity
0.33	GO:0004180	carboxypeptidase activity
0.32	GO:0003924	GTPase activity
0.32	GO:0032550	purine ribonucleoside binding
0.32	GO:0032561	guanyl ribonucleotide binding
0.32	GO:0003735	structural constituent of ribosome

0.44	GO:0005634	nucleus
0.43	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.32	GO:0015935	small ribosomal subunit
0.30	GO:0016020	membrane

sp|O14744|ANM5_HUMAN
Protein arginine N-methyltransferase 5
Search

PRMT5

0.97	Protein arginine N-methyltransferase 5

0.84	GO:0035246	peptidyl-arginine N-methylation
0.83	GO:0034969	histone arginine methylation
0.60	GO:1904990	regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
0.59	GO:0090161	Golgi ribbon formation
0.59	GO:0042118	endothelial cell activation
0.58	GO:0060161	positive regulation of dopamine receptor signaling pathway
0.54	GO:0000387	spliceosomal snRNP assembly
0.51	GO:0006353	DNA-templated transcription, termination
0.46	GO:0048742	regulation of skeletal muscle fiber development
0.43	GO:0032922	circadian regulation of gene expression

0.84	GO:0008469	histone-arginine N-methyltransferase activity
0.60	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity
0.58	GO:0008327	methyl-CpG binding
0.50	GO:0046982	protein heterodimerization activity
0.50	GO:0042802	identical protein binding
0.50	GO:0043021	ribonucleoprotein complex binding
0.42	GO:0001046	core promoter sequence-specific DNA binding
0.42	GO:0003714	transcription corepressor activity
0.37	GO:0032403	protein complex binding
0.36	GO:0003682	chromatin binding

0.65	GO:0005829	cytosol
0.59	GO:0005634	nucleus
0.58	GO:0034709	methylosome
0.50	GO:0005794	Golgi apparatus
0.47	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.35	GO:0043234	protein complex
0.30	GO:0016020	membrane

sp|O14745|NHRF1_HUMAN
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Search

SLC9A3R1

0.89	Na(+)/H(+) exchange regulatory cofactor NHE-RF

0.69	GO:0032416	negative regulation of sodium:proton antiporter activity
0.68	GO:0097291	renal phosphate ion absorption
0.68	GO:0032782	bile acid secretion
0.67	GO:0003096	renal sodium ion transport
0.67	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
0.67	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
0.66	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
0.66	GO:0044062	regulation of excretion
0.66	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway
0.66	GO:0060088	auditory receptor cell stereocilium organization

0.81	GO:0032947	protein complex scaffold activity
0.67	GO:0031698	beta-2 adrenergic receptor binding
0.66	GO:0050780	dopamine receptor binding
0.66	GO:0017081	chloride channel regulator activity
0.63	GO:0019902	phosphatase binding
0.62	GO:0008013	beta-catenin binding
0.62	GO:0043621	protein self-association
0.62	GO:0030165	PDZ domain binding
0.60	GO:0070851	growth factor receptor binding
0.44	GO:0045159	myosin II binding

0.65	GO:0097225	sperm midpiece
0.65	GO:0032426	stereocilium tip
0.64	GO:0031526	brush border membrane
0.63	GO:0005902	microvillus
0.61	GO:0012505	endomembrane system
0.61	GO:0016324	apical plasma membrane
0.58	GO:0048471	perinuclear region of cytoplasm
0.46	GO:0030175	filopodium
0.45	GO:0001726	ruffle
0.41	GO:0098857	membrane microdomain

sp|O14746|TERT_HUMAN
Telomerase reverse transcriptase
Search

TERT

0.68	Telomerase reverse transcriptase

0.69	GO:0006278	RNA-dependent DNA biosynthetic process
0.67	GO:1903704	negative regulation of production of siRNA involved in RNA interference
0.67	GO:0010833	telomere maintenance via telomere lengthening
0.66	GO:1904751	positive regulation of protein localization to nucleolus
0.65	GO:0070200	establishment of protein localization to telomere
0.64	GO:2000773	negative regulation of cellular senescence
0.64	GO:0051000	positive regulation of nitric-oxide synthase activity
0.63	GO:0090399	replicative senescence
0.63	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II
0.63	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

0.85	GO:0003721	telomerase RNA reverse transcriptase activity
0.67	GO:0098680	template-free RNA nucleotidyltransferase
0.66	GO:0070034	telomerase RNA binding
0.64	GO:0001223	transcription coactivator binding
0.61	GO:0047485	protein N-terminus binding
0.60	GO:0008022	protein C-terminus binding
0.56	GO:0051087	chaperone binding
0.55	GO:0042803	protein homodimerization activity
0.55	GO:0003677	DNA binding
0.53	GO:0003968	RNA-directed 5'-3' RNA polymerase activity

0.69	GO:0000333	telomerase catalytic core complex
0.67	GO:1990572	TERT-RMRP complex
0.62	GO:0016605	PML body
0.60	GO:0042645	mitochondrial nucleoid
0.60	GO:0000781	chromosome, telomeric region
0.58	GO:0016607	nuclear speck
0.55	GO:0005730	nucleolus
0.54	GO:0044454	nuclear chromosome part
0.52	GO:0005829	cytosol
0.43	GO:0005886	plasma membrane

0.53

EC:2.7.7.48

GO:0003968

sp|O14753|OVOL1_HUMAN
Putative transcription factor Ovo-like 1
Search

OVOL1

0.97	Ovo like transcriptional repressor 1

0.64	GO:2000647	negative regulation of stem cell proliferation
0.60	GO:0008544	epidermis development
0.60	GO:0051729	germline cell cycle switching, mitotic to meiotic cell cycle
0.58	GO:1901994	negative regulation of meiotic cell cycle phase transition
0.56	GO:0048513	animal organ development
0.55	GO:0007498	mesoderm development
0.55	GO:0006357	regulation of transcription by RNA polymerase II
0.54	GO:0045892	negative regulation of transcription, DNA-templated
0.54	GO:0072001	renal system development
0.53	GO:0007283	spermatogenesis

0.56	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.53	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.47	GO:0003682	chromatin binding
0.35	GO:0046872	metal ion binding
0.33	GO:0030246	carbohydrate binding

0.50	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|O14756|H17B6_HUMAN
17-beta-hydroxysteroid dehydrogenase type 6
Search

0.94	Retinol dehydrogenase similar protein 2

0.51	GO:0055114	oxidation-reduction process
0.47	GO:0001523	retinoid metabolic process
0.43	GO:0034754	cellular hormone metabolic process
0.42	GO:0008202	steroid metabolic process
0.41	GO:0016102	diterpenoid biosynthetic process
0.38	GO:0034308	primary alcohol metabolic process
0.37	GO:0072330	monocarboxylic acid biosynthetic process
0.36	GO:0017144	drug metabolic process
0.35	GO:0042446	hormone biosynthetic process
0.35	GO:0042447	hormone catabolic process

0.54	GO:0004745	retinol dehydrogenase activity
0.43	GO:0016229	steroid dehydrogenase activity
0.36	GO:0042803	protein homodimerization activity
0.34	GO:0009055	electron transfer activity

0.40	GO:0005783	endoplasmic reticulum
0.37	GO:0031901	early endosome membrane
0.37	GO:0043233	organelle lumen
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0031301	integral component of organelle membrane
0.36	GO:0031984	organelle subcompartment
0.35	GO:0005829	cytosol
0.35	GO:0044428	nuclear part
0.34	GO:0043232	intracellular non-membrane-bounded organelle

0.54

EC:1.1.1.105

GO:0004745

sp|O14757|CHK1_HUMAN
Serine/threonine-protein kinase Chk1
Search

CHEK1

0.49	Non-specific serine/threonine protein kinase

0.76	GO:0000077	DNA damage checkpoint
0.63	GO:0006468	protein phosphorylation
0.61	GO:0010767	regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
0.59	GO:0048096	chromatin-mediated maintenance of transcription
0.58	GO:2000615	regulation of histone H3-K9 acetylation
0.58	GO:0007093	mitotic cell cycle checkpoint
0.57	GO:1902742	apoptotic process involved in development
0.56	GO:0018210	peptidyl-threonine modification
0.56	GO:0000086	G2/M transition of mitotic cell cycle
0.55	GO:0001833	inner cell mass cell proliferation

0.67	GO:0004674	protein serine/threonine kinase activity
0.58	GO:0035173	histone kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0019904	protein domain specific binding
0.36	GO:0004576	oligosaccharyl transferase activity
0.33	GO:0050660	flavin adenine dinucleotide binding
0.33	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors

0.51	GO:0005657	replication fork
0.50	GO:0000785	chromatin
0.49	GO:0005654	nucleoplasm
0.40	GO:0000794	condensed nuclear chromosome
0.40	GO:0005813	centrosome
0.38	GO:0000781	chromosome, telomeric region
0.38	GO:0005737	cytoplasm
0.36	GO:0005615	extracellular space
0.35	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.67

GO:0004674

sp|O14763|TR10B_HUMAN
Tumor necrosis factor receptor superfamily member 10B
Search

0.88	TNF receptor superfamily member 10b

0.60	GO:0097190	apoptotic signaling pathway
0.57	GO:0071260	cellular response to mechanical stimulus
0.52	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.50	GO:0034976	response to endoplasmic reticulum stress
0.48	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.48	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.47	GO:0032496	response to lipopolysaccharide
0.46	GO:0006954	inflammatory response
0.45	GO:0042127	regulation of cell proliferation
0.44	GO:0006955	immune response

0.87	GO:0045569	TRAIL binding
0.49	GO:0005031	tumor necrosis factor-activated receptor activity
0.44	GO:0002020	protease binding
0.41	GO:0008134	transcription factor binding

0.52	GO:0009986	cell surface
0.42	GO:0005887	integral component of plasma membrane
0.36	GO:0005622	intracellular

sp|O14764|GBRD_HUMAN
Gamma-aminobutyric acid receptor subunit delta
Search

GABRD

0.97	Gamma-aminobutyric acid type A receptor delta subunit

0.60	GO:0007165	signal transduction
0.59	GO:0034220	ion transmembrane transport
0.39	GO:0007268	chemical synaptic transmission
0.38	GO:0006821	chloride transport
0.36	GO:0007601	visual perception

0.81	GO:0004890	GABA-A receptor activity
0.74	GO:0005230	extracellular ligand-gated ion channel activity
0.38	GO:0005254	chloride channel activity
0.34	GO:0005515	protein binding

0.54	GO:0005886	plasma membrane
0.47	GO:1902711	GABA-A receptor complex
0.39	GO:0034707	chloride channel complex
0.38	GO:0098794	postsynapse
0.38	GO:0030054	cell junction

sp|O14770|MEIS2_HUMAN
Homeobox protein Meis2
Search

MEIS2

0.85	Meis homeobox 2

0.69	GO:0110024	positive regulation of cardiac muscle myoblast proliferation
0.64	GO:0008542	visual learning
0.64	GO:0045638	negative regulation of myeloid cell differentiation
0.62	GO:0045931	positive regulation of mitotic cell cycle
0.62	GO:0048513	animal organ development
0.58	GO:0006366	transcription by RNA polymerase II
0.58	GO:0045944	positive regulation of transcription by RNA polymerase II
0.52	GO:1904888	cranial skeletal system development
0.52	GO:0048706	embryonic skeletal system development
0.50	GO:0048598	embryonic morphogenesis

0.62	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.61	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.57	GO:0003712	transcription cofactor activity
0.56	GO:0008134	transcription factor binding

0.61

GO:0005634

nucleus

sp|O14771|ZN213_HUMAN
Zinc finger protein 213
Search

ZNF213

0.97	Zinc finger protein with KRAB and SCAN domains 18

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:0006351	transcription, DNA-templated
0.42	GO:1902679	negative regulation of RNA biosynthetic process
0.32	GO:0006508	proteolysis
0.32	GO:0006629	lipid metabolic process

0.61	GO:0003700	DNA binding transcription factor activity
0.51	GO:0046872	metal ion binding
0.50	GO:0003676	nucleic acid binding
0.33	GO:0004197	cysteine-type endopeptidase activity
0.33	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.38	GO:0005829	cytosol
0.38	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part

0.33

EC:3.4.22

GO:0004197

sp|O14772|FPGT_HUMAN
Fucose-1-phosphate guanylyltransferase
Search

FPGT

0.97	Fucose-1-phosphate guanylyltransferase

0.38	GO:1903779	regulation of cardiac conduction
0.37	GO:0002027	regulation of heart rate
0.37	GO:0006468	protein phosphorylation
0.36	GO:0006004	fucose metabolic process
0.33	GO:0035556	intracellular signal transduction
0.32	GO:0006508	proteolysis

0.57	GO:0016772	transferase activity, transferring phosphorus-containing groups
0.36	GO:0032555	purine ribonucleotide binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0140096	catalytic activity, acting on a protein
0.36	GO:0032550	purine ribonucleoside binding
0.36	GO:0019001	guanyl nucleotide binding
0.35	GO:0030554	adenyl nucleotide binding
0.35	GO:0008144	drug binding
0.33	GO:0004871	signal transducer activity
0.32	GO:0004386	helicase activity

0.35	GO:0005829	cytosol
0.33	GO:0005634	nucleus

0.57

GO:0016772

sp|O14773|TPP1_HUMAN
Tripeptidyl-peptidase 1
Search

TPP1

0.93	Tripeptidyl peptidase I

0.62	GO:0045453	bone resorption
0.61	GO:0006508	proteolysis
0.59	GO:0050885	neuromuscular process controlling balance
0.57	GO:0007040	lysosome organization
0.56	GO:0007399	nervous system development
0.56	GO:0043171	peptide catabolic process
0.55	GO:0030855	epithelial cell differentiation
0.42	GO:0007626	locomotory behavior
0.36	GO:0036498	IRE1-mediated unfolded protein response
0.34	GO:0030163	protein catabolic process

0.69	GO:0004252	serine-type endopeptidase activity
0.63	GO:0008240	tripeptidyl-peptidase activity
0.49	GO:0046872	metal ion binding
0.37	GO:0042277	peptide binding
0.35	GO:0005515	protein binding

0.57	GO:0005764	lysosome
0.46	GO:0005739	mitochondrion
0.45	GO:0042470	melanosome
0.37	GO:0070062	extracellular exosome
0.36	GO:0005775	vacuolar lumen
0.32	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0004252

sp|O14775|GBB5_HUMAN
Guanine nucleotide-binding protein subunit beta-5
Search

GNB5

0.86	G protein subunit beta 5

0.73	GO:1901386	negative regulation of voltage-gated calcium channel activity
0.71	GO:0007212	dopamine receptor signaling pathway
0.64	GO:0043547	positive regulation of GTPase activity

0.79	GO:0031682	G-protein gamma-subunit binding
0.65	GO:0051087	chaperone binding
0.64	GO:0005096	GTPase activator activity

0.72	GO:0001917	photoreceptor inner segment
0.70	GO:0001750	photoreceptor outer segment
0.69	GO:0043209	myelin sheath
0.58	GO:0005829	cytosol
0.53	GO:0005634	nucleus
0.49	GO:0005886	plasma membrane

sp|O14776|TCRG1_HUMAN
Transcription elongation regulator 1
Search

TCERG1

0.91	Transcription elongation regulator 1

0.78	GO:0000122	negative regulation of transcription by RNA polymerase II
0.40	GO:0006366	transcription by RNA polymerase II

0.86	GO:0070064	proline-rich region binding
0.85	GO:0001103	RNA polymerase II repressing transcription factor binding
0.85	GO:0001106	RNA polymerase II transcription corepressor activity
0.74	GO:0042802	identical protein binding
0.41	GO:0003713	transcription coactivator activity
0.39	GO:0003723	RNA binding
0.37	GO:0003700	DNA binding transcription factor activity

0.70

GO:0005654

nucleoplasm

sp|O14777|NDC80_HUMAN
Kinetochore protein NDC80 homolog
Search

NDC80

0.92	NDC80 kinetochore complex component

0.86	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint
0.85	GO:0051315	attachment of mitotic spindle microtubules to kinetochore
0.85	GO:1905342	positive regulation of protein localization to kinetochore
0.83	GO:0000132	establishment of mitotic spindle orientation
0.82	GO:0007052	mitotic spindle organization
0.80	GO:0051383	kinetochore organization
0.45	GO:0051301	cell division
0.40	GO:0051311	meiotic metaphase plate congression
0.40	GO:0007143	female meiotic nuclear division
0.39	GO:0051225	spindle assembly

0.71	GO:0042802	identical protein binding
0.58	GO:0005200	structural constituent of cytoskeleton

0.86	GO:0031262	Ndc80 complex
0.80	GO:0000777	condensed chromosome kinetochore
0.79	GO:0000780	condensed nuclear chromosome, centromeric region
0.75	GO:0005813	centrosome
0.68	GO:0005654	nucleoplasm
0.37	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O14782|KIF3C_HUMAN
Kinesin-like protein KIF3C
Search

sp|O14786|NRP1_HUMAN
Neuropilin-1
Search

NRP1

0.90	Neuropilin

0.86	GO:0035767	endothelial cell chemotaxis
0.85	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.85	GO:0038084	vascular endothelial growth factor signaling pathway
0.83	GO:0071526	semaphorin-plexin signaling pathway
0.82	GO:0001525	angiogenesis
0.81	GO:0007411	axon guidance
0.77	GO:0009887	animal organ morphogenesis
0.61	GO:0038189	neuropilin signaling pathway
0.60	GO:1905040	otic placode development
0.60	GO:1902336	positive regulation of retinal ganglion cell axon guidance

0.85	GO:0005021	vascular endothelial growth factor-activated receptor activity
0.84	GO:0017154	semaphorin receptor activity
0.82	GO:0019838	growth factor binding
0.53	GO:0046872	metal ion binding
0.53	GO:0005096	GTPase activator activity
0.52	GO:0019901	protein kinase binding
0.41	GO:0008201	heparin binding
0.35	GO:0015026	coreceptor activity
0.35	GO:0019955	cytokine binding

0.58	GO:0097443	sorting endosome
0.56	GO:0005883	neurofilament
0.55	GO:0005925	focal adhesion
0.53	GO:0030424	axon
0.53	GO:0005769	early endosome
0.49	GO:0005829	cytosol
0.43	GO:0005886	plasma membrane
0.39	GO:0030426	growth cone
0.38	GO:0043025	neuronal cell body
0.37	GO:0009986	cell surface

sp|O14787|TNPO2_HUMAN
Transportin-2
Search

TNPO2

0.82	Transportin-2

0.67	GO:0006886	intracellular protein transport
0.50	GO:0006610	ribosomal protein import into nucleus
0.49	GO:0006607	NLS-bearing protein import into nucleus
0.37	GO:0051148	negative regulation of muscle cell differentiation
0.34	GO:0010469	regulation of receptor activity
0.33	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine

0.78	GO:0008536	Ran GTPase binding
0.49	GO:0008139	nuclear localization sequence binding
0.44	GO:0008565	protein transporter activity
0.34	GO:0005179	hormone activity
0.33	GO:0003723	RNA binding

0.59	GO:0005634	nucleus
0.43	GO:0012505	endomembrane system
0.43	GO:0031974	membrane-enclosed lumen
0.41	GO:0031967	organelle envelope
0.41	GO:0031090	organelle membrane
0.37	GO:0005737	cytoplasm
0.34	GO:0005576	extracellular region
0.33	GO:0031982	vesicle

sp|O14788|TNF11_HUMAN
Tumor necrosis factor ligand superfamily member 11
Search

TNFSF11

0.97	Tumor necrosis factor ligand superfamily member 11

0.74	GO:0006955	immune response
0.73	GO:0051466	positive regulation of corticotropin-releasing hormone secretion
0.72	GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion
0.72	GO:0071848	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
0.72	GO:0002158	osteoclast proliferation
0.71	GO:2001206	positive regulation of osteoclast development
0.71	GO:0034112	positive regulation of homotypic cell-cell adhesion
0.70	GO:0038001	paracrine signaling
0.69	GO:0045780	positive regulation of bone resorption
0.69	GO:0045453	bone resorption

0.84	GO:0005164	tumor necrosis factor receptor binding
0.63	GO:0005125	cytokine activity

0.40	GO:0005622	intracellular
0.39	GO:0005615	extracellular space
0.36	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O14791|APOL1_HUMAN
Apolipoprotein L1
Search

APOL1

0.97	Apolipoprotein L1

0.75	GO:0042157	lipoprotein metabolic process
0.74	GO:0006869	lipid transport
0.37	GO:0008203	cholesterol metabolic process
0.36	GO:0006952	defense response
0.36	GO:0043687	post-translational protein modification
0.36	GO:0031640	killing of cells of other organism
0.35	GO:0019835	cytolysis
0.35	GO:1902476	chloride transmembrane transport
0.35	GO:0006955	immune response
0.35	GO:0006898	receptor-mediated endocytosis

0.72	GO:0008289	lipid binding
0.35	GO:0005254	chloride channel activity
0.35	GO:0008035	high-density lipoprotein particle binding
0.35	GO:0005515	protein binding
0.33	GO:0005319	lipid transporter activity
0.33	GO:0004871	signal transducer activity

0.66	GO:0005576	extracellular region
0.36	GO:1990777	lipoprotein particle
0.36	GO:0005788	endoplasmic reticulum lumen
0.33	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

sp|O14792|HS3S1_HUMAN
Heparan sulfate glucosamine 3-O-sulfotransferase 1
Search

HS3ST1

0.54	Sulfotransferase

0.45	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification
0.44	GO:0046596	regulation of viral entry into host cell
0.44	GO:0050819	negative regulation of coagulation
0.43	GO:0006477	protein sulfation
0.39	GO:0060271	cilium assembly
0.37	GO:0055003	cardiac myofibril assembly
0.36	GO:0045214	sarcomere organization
0.36	GO:0060047	heart contraction
0.33	GO:0006313	transposition, DNA-mediated
0.33	GO:0015074	DNA integration

0.77	GO:0008146	sulfotransferase activity
0.32	GO:0003677	DNA binding

0.30

GO:0016020

membrane

0.77

GO:0008146

sp|O14793|GDF8_HUMAN
Growth/differentiation factor 8
Search

MSTN

0.94	Growth differentiation factor 8

0.76	GO:2000818	negative regulation of myoblast proliferation
0.76	GO:0010469	regulation of receptor activity
0.75	GO:0014859	negative regulation of skeletal muscle cell proliferation
0.75	GO:0048642	negative regulation of skeletal muscle tissue development
0.74	GO:0014842	regulation of skeletal muscle satellite cell proliferation
0.73	GO:2001014	regulation of skeletal muscle cell differentiation
0.68	GO:0045596	negative regulation of cell differentiation
0.59	GO:0033002	muscle cell proliferation
0.59	GO:0014732	skeletal muscle atrophy
0.59	GO:0048631	regulation of skeletal muscle tissue growth

0.78	GO:0008083	growth factor activity
0.60	GO:0008201	heparin binding
0.55	GO:0042802	identical protein binding
0.53	GO:0005125	cytokine activity
0.48	GO:0046983	protein dimerization activity
0.46	GO:0005160	transforming growth factor beta receptor binding

0.66	GO:0005576	extracellular region
0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|O14795|UN13B_HUMAN
Protein unc-13 homolog B
Search

UNC13B

0.91	Putative neurotransmitter release regulator unc-13

0.78	GO:0007268	chemical synaptic transmission
0.62	GO:0035556	intracellular signal transduction
0.55	GO:0017156	calcium ion regulated exocytosis
0.55	GO:0097480	establishment of synaptic vesicle localization
0.55	GO:0099504	synaptic vesicle cycle
0.55	GO:0099003	vesicle-mediated transport in synapse
0.54	GO:0099643	signal release from synapse
0.54	GO:0031914	negative regulation of synaptic plasticity
0.53	GO:0048172	regulation of short-term neuronal synaptic plasticity
0.53	GO:0071333	cellular response to glucose stimulus

0.85	GO:0019992	diacylglycerol binding
0.74	GO:0005543	phospholipid binding
0.69	GO:0005509	calcium ion binding
0.54	GO:0030742	GTP-dependent protein binding
0.37	GO:0001566	non-kinase phorbol ester receptor activity
0.36	GO:0005516	calmodulin binding
0.35	GO:0017137	Rab GTPase binding
0.35	GO:0017075	syntaxin-1 binding
0.33	GO:0003735	structural constituent of ribosome

0.53	GO:0097470	ribbon synapse
0.53	GO:0032009	early phagosome
0.53	GO:0044305	calyx of Held
0.53	GO:0048786	presynaptic active zone
0.51	GO:0031594	neuromuscular junction
0.48	GO:0043195	terminal bouton
0.47	GO:0005794	Golgi apparatus
0.46	GO:0005829	cytosol
0.37	GO:0030054	cell junction
0.34	GO:0097060	synaptic membrane

sp|O14796|SH21B_HUMAN
SH2 domain-containing protein 1B
Search

SH2D1B

0.97	SH2 domain-containing protein 1B

0.60	GO:0002717	positive regulation of natural killer cell mediated immunity
0.57	GO:0042269	regulation of natural killer cell mediated cytotoxicity
0.56	GO:0001912	positive regulation of leukocyte mediated cytotoxicity
0.50	GO:0046856	phosphatidylinositol dephosphorylation
0.50	GO:0002716	negative regulation of natural killer cell mediated immunity
0.50	GO:0006955	immune response
0.50	GO:0001911	negative regulation of leukocyte mediated cytotoxicity
0.47	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
0.46	GO:0032814	regulation of natural killer cell activation
0.45	GO:0018108	peptidyl-tyrosine phosphorylation

0.44	GO:0060090	molecular adaptor activity
0.41	GO:0005515	protein binding
0.39	GO:0016787	hydrolase activity
0.34	GO:0035091	phosphatidylinositol binding

0.44	GO:0005622	intracellular
0.35	GO:0005886	plasma membrane

0.39

GO:0016787

sp|O14798|TR10C_HUMAN
Tumor necrosis factor receptor superfamily member 10C
Search

0.91	Tumor necrosis factor receptor superfamily member 10C

0.63	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.62	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.61	GO:0032496	response to lipopolysaccharide
0.60	GO:0097190	apoptotic signaling pathway
0.59	GO:0006954	inflammatory response
0.57	GO:0042127	regulation of cell proliferation
0.56	GO:0006955	immune response
0.53	GO:0007275	multicellular organism development
0.48	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
0.46	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

0.87	GO:0045569	TRAIL binding
0.64	GO:0005031	tumor necrosis factor-activated receptor activity
0.45	GO:0002020	protease binding
0.42	GO:0008134	transcription factor binding

0.52	GO:0031225	anchored component of membrane
0.52	GO:0005887	integral component of plasma membrane
0.42	GO:0009986	cell surface
0.34	GO:0005622	intracellular

sp|O14802|RPC1_HUMAN
DNA-directed RNA polymerase III subunit RPC1
Search

POLR3A

0.49	DNA-directed RNA polymerase subunit

0.57	GO:0006351	transcription, DNA-templated
0.57	GO:0032728	positive regulation of interferon-beta production
0.56	GO:1903146	regulation of autophagy of mitochondrion
0.55	GO:1903955	positive regulation of protein targeting to mitochondrion
0.52	GO:0045087	innate immune response
0.36	GO:0051607	defense response to virus

0.69	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.54	GO:0003677	DNA binding
0.50	GO:0003682	chromatin binding
0.34	GO:0046872	metal ion binding

0.55	GO:0005666	DNA-directed RNA polymerase III complex
0.34	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0003899

sp|O14804|TAAR5_HUMAN
Trace amine-associated receptor 5
Search

TAAR5

0.97	Trace amine-associated receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.53	GO:0007606	sensory perception of chemical stimulus
0.51	GO:0007166	cell surface receptor signaling pathway
0.36	GO:0007610	behavior
0.35	GO:0042596	fear response
0.35	GO:0051703	intraspecies interaction between organisms
0.35	GO:0007618	mating
0.34	GO:0048609	multicellular organismal reproductive process
0.34	GO:0006952	defense response
0.34	GO:0032098	regulation of appetite

0.85	GO:0001594	trace-amine receptor activity
0.36	GO:1990080	2-phenylethylamine receptor activity
0.34	GO:0099589	serotonin receptor activity
0.33	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
0.33	GO:0099528	G-protein coupled neurotransmitter receptor activity
0.33	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors

0.47	GO:0005887	integral component of plasma membrane
0.32	GO:0005737	cytoplasm

0.33

EC:3.5.1

GO:0016811

sp|O14807|RASM_HUMAN
Ras-related protein M-Ras
Search

MRAS

0.97	Muscle RAS oncogene homolog

0.61	GO:0007165	signal transduction
0.54	GO:1990830	cellular response to leukemia inhibitory factor
0.37	GO:0061817	endoplasmic reticulum-plasma membrane tethering
0.36	GO:0006869	lipid transport
0.34	GO:0007517	muscle organ development
0.34	GO:0030036	actin cytoskeleton organization
0.33	GO:0043066	negative regulation of apoptotic process

0.68	GO:0003924	GTPase activity
0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0032561	guanyl ribonucleotide binding
0.58	GO:0030742	GTP-dependent protein binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0008289	lipid binding

0.36	GO:0070062	extracellular exosome
0.34	GO:0005886	plasma membrane
0.32	GO:0005622	intracellular

sp|O14810|CPLX1_HUMAN
Complexin-1
Search

CPLX1

0.94	Nj-synaphin 2

0.76	GO:0006836	neurotransmitter transport
0.52	GO:0030073	insulin secretion
0.51	GO:0017156	calcium ion regulated exocytosis
0.51	GO:0048489	synaptic vesicle transport
0.51	GO:0031915	positive regulation of synaptic plasticity
0.51	GO:0099504	synaptic vesicle cycle
0.51	GO:0099643	signal release from synapse
0.51	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.47	GO:0001505	regulation of neurotransmitter levels
0.39	GO:0043303	mast cell degranulation

0.84	GO:0019905	syntaxin binding
0.48	GO:0005326	neurotransmitter transporter activity
0.37	GO:0048306	calcium-dependent protein binding

0.51	GO:0031201	SNARE complex
0.49	GO:0098793	presynapse
0.40	GO:0044306	neuron projection terminus
0.40	GO:0033267	axon part
0.40	GO:0005829	cytosol
0.40	GO:0043025	neuronal cell body
0.40	GO:0030425	dendrite
0.39	GO:0042629	mast cell granule
0.34	GO:0030054	cell junction
0.33	GO:0005634	nucleus

sp|O14813|PHX2A_HUMAN
Paired mesoderm homeobox protein 2A
Search

PHOX2A

0.95	LOW QUALITY PROTEIN: paired mesoderm homeobox protein 2B

0.74	GO:0003357	noradrenergic neuron differentiation
0.71	GO:0048857	neural nucleus development
0.68	GO:0048485	sympathetic nervous system development
0.68	GO:0030902	hindbrain development
0.68	GO:0043576	regulation of respiratory gaseous exchange
0.68	GO:0048486	parasympathetic nervous system development
0.66	GO:0021545	cranial nerve development
0.64	GO:0021953	central nervous system neuron differentiation
0.60	GO:0030901	midbrain development
0.60	GO:0021517	ventral spinal cord development

0.61	GO:0043565	sequence-specific DNA binding
0.60	GO:0001012	RNA polymerase II regulatory region DNA binding
0.56	GO:0003690	double-stranded DNA binding
0.49	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding

0.60	GO:0005634	nucleus
0.57	GO:0000785	chromatin
0.53	GO:0043233	organelle lumen

sp|O14815|CAN9_HUMAN
Calpain-9
Search

CAPN9

0.95	Neutral protease calpain 9a

0.77	GO:0007586	digestion
0.61	GO:0006508	proteolysis
0.39	GO:0021785	branchiomotor neuron axon guidance
0.38	GO:0007420	brain development
0.36	GO:0043066	negative regulation of apoptotic process
0.34	GO:0051493	regulation of cytoskeleton organization
0.33	GO:0045214	sarcomere organization

0.82	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.70	GO:0005509	calcium ion binding

0.45	GO:0005622	intracellular
0.37	GO:0097223	sperm part
0.36	GO:0031982	vesicle
0.35	GO:0012505	endomembrane system
0.32	GO:0005886	plasma membrane

sp|O14817|TSN4_HUMAN
Tetraspanin-4
Search

TSPAN4

0.59	Tetraspanin

0.47	GO:0006461	protein complex assembly
0.44	GO:0007166	cell surface receptor signaling pathway
0.33	GO:0006313	transposition, DNA-mediated
0.33	GO:0015074	DNA integration

0.54	GO:0003823	antigen binding
0.53	GO:0005178	integrin binding
0.32	GO:0003677	DNA binding

0.48	GO:0031982	vesicle
0.42	GO:0005887	integral component of plasma membrane
0.36	GO:0005925	focal adhesion

sp|O14818|PSA7_HUMAN
Proteasome subunit alpha type-7
Search

PSMA7

0.49	Proteasome endopeptidase complex

0.72	GO:0051603	proteolysis involved in cellular protein catabolic process
0.66	GO:0043632	modification-dependent macromolecule catabolic process
0.37	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.37	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.37	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.37	GO:0038095	Fc-epsilon receptor signaling pathway
0.37	GO:1902036	regulation of hematopoietic stem cell differentiation
0.37	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
0.36	GO:0070498	interleukin-1-mediated signaling pathway
0.36	GO:0038061	NIK/NF-kappaB signaling

0.77	GO:0004298	threonine-type endopeptidase activity
0.48	GO:0042802	identical protein binding
0.33	GO:0046982	protein heterodimerization activity
0.33	GO:0003743	translation initiation factor activity
0.33	GO:0003700	DNA binding transcription factor activity

0.79	GO:0019773	proteasome core complex, alpha-subunit complex
0.57	GO:0005634	nucleus
0.50	GO:0098794	postsynapse
0.49	GO:0005737	cytoplasm
0.47	GO:1990111	spermatoproteasome complex
0.38	GO:0070062	extracellular exosome
0.36	GO:0070013	intracellular organelle lumen
0.34	GO:0044446	intracellular organelle part
0.33	GO:0000428	DNA-directed RNA polymerase complex
0.33	GO:0005667	transcription factor complex

0.77

EC:3.4.25

GO:0004298

sp|O14827|RGRF2_HUMAN
Ras-specific guanine nucleotide-releasing factor 2
Search

RASGRF2

0.90	Ras protein specific guanine nucleotide releasing factor 2

0.78	GO:0035023	regulation of Rho protein signal transduction
0.73	GO:0007264	small GTPase mediated signal transduction
0.66	GO:0065009	regulation of molecular function
0.55	GO:0034976	response to endoplasmic reticulum stress
0.37	GO:0035020	regulation of Rac protein signal transduction
0.37	GO:1900449	regulation of glutamate receptor signaling pathway
0.37	GO:0048168	regulation of neuronal synaptic plasticity
0.36	GO:1904062	regulation of cation transmembrane transport
0.36	GO:0008283	cell proliferation
0.36	GO:0031175	neuron projection development

0.77	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.37	GO:0005516	calmodulin binding
0.37	GO:0035254	glutamate receptor binding
0.35	GO:0030971	receptor tyrosine kinase binding
0.35	GO:0008022	protein C-terminus binding
0.34	GO:0005096	GTPase activator activity
0.33	GO:0030983	mismatched DNA binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.50	GO:0005783	endoplasmic reticulum
0.36	GO:0030426	growth cone
0.36	GO:0005829	cytosol
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.35	GO:0031984	organelle subcompartment
0.35	GO:0097440	apical dendrite
0.35	GO:0016327	apicolateral plasma membrane
0.35	GO:0016323	basolateral plasma membrane
0.34	GO:0043025	neuronal cell body
0.30	GO:0016021	integral component of membrane

sp|O14828|SCAM3_HUMAN
Secretory carrier-associated membrane protein 3
Search

SCAMP3

0.68	Secretory carrier-associated membrane protein 3

0.65	GO:0015031	protein transport
0.39	GO:0032526	response to retinoic acid
0.38	GO:0006887	exocytosis
0.38	GO:0006468	protein phosphorylation
0.37	GO:0045721	negative regulation of gluconeogenesis
0.37	GO:0010212	response to ionizing radiation
0.36	GO:0043484	regulation of RNA splicing
0.36	GO:0018212	peptidyl-tyrosine modification
0.35	GO:0006892	post-Golgi vesicle-mediated transport
0.34	GO:0006836	neurotransmitter transport

0.52	GO:0031625	ubiquitin protein ligase binding
0.38	GO:0004672	protein kinase activity
0.36	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0042802	identical protein binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0019905	syntaxin binding
0.33	GO:0019904	protein domain specific binding

0.42	GO:0043231	intracellular membrane-bounded organelle
0.41	GO:0042589	zymogen granule membrane
0.40	GO:0055038	recycling endosome membrane
0.40	GO:0030672	synaptic vesicle membrane
0.39	GO:0031984	organelle subcompartment
0.39	GO:0070062	extracellular exosome
0.34	GO:0043195	terminal bouton
0.33	GO:0030136	clathrin-coated vesicle
0.30	GO:0016021	integral component of membrane

sp|O14829|PPE1_HUMAN
Serine/threonine-protein phosphatase with EF-hands 1
Search

PPEF1

0.52	Serine/threonine-protein phosphatase with EF-hands 1

0.73	GO:0050906	detection of stimulus involved in sensory perception
0.71	GO:0006470	protein dephosphorylation
0.40	GO:0010801	negative regulation of peptidyl-threonine phosphorylation
0.40	GO:0043409	negative regulation of MAPK cascade
0.38	GO:0022400	regulation of rhodopsin mediated signaling pathway

0.72	GO:0004721	phosphoprotein phosphatase activity
0.70	GO:0030145	manganese ion binding
0.69	GO:0005509	calcium ion binding
0.61	GO:0005506	iron ion binding
0.41	GO:0031435	mitogen-activated protein kinase kinase kinase binding
0.40	GO:0051879	Hsp90 protein binding
0.40	GO:0030544	Hsp70 protein binding

0.35	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.72

GO:0004721

sp|O14830|PPE2_HUMAN
Serine/threonine-protein phosphatase with EF-hands 2
Search

PPEF2

0.54	Serine/threonine-protein phosphatase with EF-hands 2

0.74	GO:0050906	detection of stimulus involved in sensory perception
0.71	GO:0006470	protein dephosphorylation
0.56	GO:0010801	negative regulation of peptidyl-threonine phosphorylation
0.55	GO:0043409	negative regulation of MAPK cascade
0.37	GO:0007601	visual perception
0.36	GO:0043506	regulation of JUN kinase activity

0.72	GO:0004721	phosphoprotein phosphatase activity
0.71	GO:0030145	manganese ion binding
0.69	GO:0005509	calcium ion binding
0.62	GO:0005506	iron ion binding
0.59	GO:0031435	mitogen-activated protein kinase kinase kinase binding
0.58	GO:0051879	Hsp90 protein binding
0.58	GO:0030544	Hsp70 protein binding

0.37	GO:0001917	photoreceptor inner segment
0.36	GO:0001750	photoreceptor outer segment
0.32	GO:0005737	cytoplasm

0.72

GO:0004721

sp|O14832|PAHX_HUMAN
Phytanoyl-CoA dioxygenase, peroxisomal
Search

PHYH

0.92	Phytanoyl-CoA dioxygenase, peroxisomal

0.67	GO:0001561	fatty acid alpha-oxidation
0.60	GO:0097089	methyl-branched fatty acid metabolic process
0.55	GO:0006103	2-oxoglutarate metabolic process
0.49	GO:0006720	isoprenoid metabolic process
0.32	GO:0055085	transmembrane transport

0.69	GO:0051213	dioxygenase activity
0.53	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.53	GO:0008198	ferrous iron binding
0.50	GO:0043177	organic acid binding
0.42	GO:0048037	cofactor binding
0.41	GO:0043168	anion binding
0.40	GO:0048029	monosaccharide binding
0.37	GO:0019842	vitamin binding
0.35	GO:0005515	protein binding
0.33	GO:0005215	transporter activity

0.52	GO:0005777	peroxisome
0.45	GO:0005739	mitochondrion
0.36	GO:0031907	microbody lumen
0.30	GO:0016020	membrane

0.53

GO:0016705

sp|O14836|TR13B_HUMAN
Tumor necrosis factor receptor superfamily member 13B
Search

TNFRSF13B

0.97	Tumor necrosis factor receptor superfamily member 13B

0.59	GO:0030889	negative regulation of B cell proliferation
0.58	GO:0001782	B cell homeostasis
0.56	GO:0002244	hematopoietic progenitor cell differentiation
0.47	GO:0007166	cell surface receptor signaling pathway
0.42	GO:0002250	adaptive immune response
0.41	GO:0071356	cellular response to tumor necrosis factor

0.45	GO:0004872	receptor activity
0.37	GO:0005515	protein binding

0.67	GO:0005887	integral component of plasma membrane
0.45	GO:0009897	external side of plasma membrane

sp|O14841|OPLA_HUMAN
5-oxoprolinase
Search

OPLAH

0.50	5-oxoprolinase, ATP-hydrolysing

0.47	GO:0006749	glutathione metabolic process
0.37	GO:0035335	peptidyl-tyrosine dephosphorylation
0.35	GO:0019184	nonribosomal peptide biosynthetic process
0.34	GO:0042398	cellular modified amino acid biosynthetic process
0.34	GO:0044272	sulfur compound biosynthetic process
0.33	GO:0051188	cofactor biosynthetic process

0.52	GO:0017168	5-oxoprolinase (ATP-hydrolyzing) activity
0.37	GO:0004725	protein tyrosine phosphatase activity
0.35	GO:0030554	adenyl nucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0032555	purine ribonucleotide binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0046872	metal ion binding

0.45	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.52	EC:3.5.2.9	GO:0017168
0.52	KEGG:R00251	GO:0017168

sp|O14842|FFAR1_HUMAN
Free fatty acid receptor 1
Search

FFAR1

0.94	Free fatty acid receptor

0.75	GO:0030073	insulin secretion
0.75	GO:0070542	response to fatty acid
0.74	GO:0032024	positive regulation of insulin secretion
0.73	GO:0051928	positive regulation of calcium ion transport
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.70	GO:0042593	glucose homeostasis
0.39	GO:0010522	regulation of calcium ion transport into cytosol
0.39	GO:0032846	positive regulation of homeostatic process
0.39	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.37	GO:0065009	regulation of molecular function

0.75	GO:0045125	bioactive lipid receptor activity
0.44	GO:0008289	lipid binding
0.38	GO:0005085	guanyl-nucleotide exchange factor activity
0.37	GO:0033293	monocarboxylic acid binding

0.59

GO:0005887

integral component of plasma membrane

sp|O14843|FFAR3_HUMAN
Free fatty acid receptor 3
Search

0.59	G-protein coupled receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.62	GO:0002879	positive regulation of acute inflammatory response to non-antigenic stimulus
0.59	GO:0002385	mucosal immune response
0.58	GO:0002720	positive regulation of cytokine production involved in immune response
0.58	GO:0071398	cellular response to fatty acid
0.57	GO:0032722	positive regulation of chemokine production
0.56	GO:0090276	regulation of peptide hormone secretion
0.56	GO:0003062	regulation of heart rate by chemical signal
0.55	GO:0045760	positive regulation of action potential
0.55	GO:0051050	positive regulation of transport

0.72	GO:0004930	G-protein coupled receptor activity
0.44	GO:0001653	peptide receptor activity
0.38	GO:0008289	lipid binding
0.32	GO:0005515	protein binding
0.32	GO:0008233	peptidase activity

0.39	GO:0005886	plasma membrane
0.35	GO:0042995	cell projection
0.32	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

0.32

GO:0008233

sp|O14862|AIM2_HUMAN
Interferon-inducible protein AIM2
Search

AIM2

0.96	Myeloid cell nuclear differentiation antigen

0.79	GO:0070269	pyroptosis
0.78	GO:0035458	cellular response to interferon-beta
0.78	GO:0050702	interleukin-1 beta secretion
0.77	GO:0050718	positive regulation of interleukin-1 beta secretion
0.76	GO:0032461	positive regulation of protein oligomerization
0.76	GO:0002230	positive regulation of defense response to virus by host
0.73	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.73	GO:0002253	activation of immune response
0.73	GO:0032088	negative regulation of NF-kappaB transcription factor activity
0.73	GO:2001056	positive regulation of cysteine-type endopeptidase activity

0.68	GO:0042802	identical protein binding
0.66	GO:0003690	double-stranded DNA binding
0.50	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.50	GO:0001047	core promoter binding
0.48	GO:0001012	RNA polymerase II regulatory region DNA binding
0.46	GO:0008134	transcription factor binding
0.43	GO:0043565	sequence-specific DNA binding

0.79	GO:0097169	AIM2 inflammasome complex
0.66	GO:0031981	nuclear lumen
0.54	GO:0005739	mitochondrion
0.46	GO:0043232	intracellular non-membrane-bounded organelle
0.38	GO:1904813	ficolin-1-rich granule lumen
0.38	GO:0035578	azurophil granule lumen
0.36	GO:0070062	extracellular exosome

sp|O14863|ZNT4_HUMAN
Zinc transporter 4
Search

SLC30A4

0.97	Zinc transporter 4

0.62	GO:0055069	zinc ion homeostasis
0.62	GO:0061088	regulation of sequestering of zinc ion
0.61	GO:0098655	cation transmembrane transport
0.54	GO:0006829	zinc II ion transport
0.50	GO:0010043	response to zinc ion
0.49	GO:0009636	response to toxic substance
0.46	GO:0072503	cellular divalent inorganic cation homeostasis
0.45	GO:0098660	inorganic ion transmembrane transport
0.45	GO:0046916	cellular transition metal ion homeostasis
0.39	GO:0051238	sequestering of metal ion

0.61	GO:0008324	cation transmembrane transporter activity
0.44	GO:0015318	inorganic molecular entity transmembrane transporter activity
0.36	GO:0042803	protein homodimerization activity
0.32	GO:0008270	zinc ion binding
0.32	GO:0003676	nucleic acid binding

0.57	GO:0005770	late endosome
0.39	GO:0005765	lysosomal membrane
0.38	GO:0010008	endosome membrane
0.38	GO:0030141	secretory granule
0.34	GO:0005886	plasma membrane
0.32	GO:0030658	transport vesicle membrane
0.32	GO:0005794	Golgi apparatus
0.30	GO:0031224	intrinsic component of membrane

sp|O14867|BACH1_HUMAN
Transcription regulator protein BACH1
Search

BACH1

0.94	Transcription regulator protein BACH1

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:0006351	transcription, DNA-templated
0.56	GO:0010468	regulation of gene expression
0.50	GO:0000086	G2/M transition of mitotic cell cycle
0.50	GO:0071456	cellular response to hypoxia
0.49	GO:0000082	G1/S transition of mitotic cell cycle
0.45	GO:1902679	negative regulation of RNA biosynthetic process
0.44	GO:1902680	positive regulation of RNA biosynthetic process
0.42	GO:0006281	DNA repair

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.45	GO:0001067	regulatory region nucleic acid binding
0.40	GO:0004842	ubiquitin-protein transferase activity
0.38	GO:0005515	protein binding
0.36	GO:0020037	heme binding

0.61	GO:0005634	nucleus
0.42	GO:0031463	Cul3-RING ubiquitin ligase complex
0.37	GO:0005829	cytosol

0.40

GO:0004842

sp|O14874|BCKD_HUMAN
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
Search

BCKDK

0.96	Branched chain alpha-ketoacid dehydrogenase kinase

0.56	GO:0016310	phosphorylation
0.46	GO:0036211	protein modification process
0.43	GO:0044267	cellular protein metabolic process
0.41	GO:0009083	branched-chain amino acid catabolic process

0.56	GO:0016772	transferase activity, transferring phosphorus-containing groups
0.44	GO:0140096	catalytic activity, acting on a protein
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding

0.46	GO:0005739	mitochondrion
0.41	GO:0045240	dihydrolipoyl dehydrogenase complex
0.39	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.56

GO:0016772

sp|O14879|IFIT3_HUMAN
Interferon-induced protein with tetratricopeptide repeats 3
Search

0.97	Interferon-induced protein with tetratricopeptide repeats 3

0.81	GO:0035457	cellular response to interferon-alpha
0.60	GO:0009615	response to virus
0.53	GO:0042981	regulation of apoptotic process
0.52	GO:0002252	immune effector process
0.51	GO:0098542	defense response to other organism
0.50	GO:0008285	negative regulation of cell proliferation
0.50	GO:0043069	negative regulation of programmed cell death
0.49	GO:0032091	negative regulation of protein binding
0.47	GO:0043068	positive regulation of programmed cell death
0.44	GO:0045071	negative regulation of viral genome replication

0.48	GO:0042802	identical protein binding
0.44	GO:0008266	poly(U) RNA binding
0.43	GO:0000339	RNA cap binding
0.40	GO:0003690	double-stranded DNA binding
0.39	GO:0000049	tRNA binding

0.49	GO:0005829	cytosol
0.45	GO:0043231	intracellular membrane-bounded organelle
0.43	GO:0032587	ruffle membrane
0.43	GO:0012505	endomembrane system
0.42	GO:0045177	apical part of cell
0.42	GO:1902554	serine/threonine protein kinase complex
0.41	GO:0015629	actin cytoskeleton
0.33	GO:0044216	other organism cell
0.33	GO:0018995	host

sp|O14880|MGST3_HUMAN
Microsomal glutathione S-transferase 3
Search

MGST3

0.90	Microsomal glutathione S-transferase

0.58	GO:0019370	leukotriene biosynthetic process
0.49	GO:0098869	cellular oxidant detoxification
0.45	GO:0006629	lipid metabolic process
0.38	GO:0010243	response to organonitrogen compound
0.36	GO:1901685	glutathione derivative metabolic process
0.35	GO:0006805	xenobiotic metabolic process
0.34	GO:0044272	sulfur compound biosynthetic process
0.32	GO:1901566	organonitrogen compound biosynthetic process
0.32	GO:0055114	oxidation-reduction process

0.59	GO:0004464	leukotriene-C4 synthase activity
0.54	GO:0004602	glutathione peroxidase activity
0.48	GO:0016740	transferase activity
0.33	GO:0005515	protein binding

0.43	GO:0005635	nuclear envelope
0.42	GO:0005783	endoplasmic reticulum
0.37	GO:0070062	extracellular exosome
0.36	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0031984	organelle subcompartment
0.35	GO:0031090	organelle membrane
0.30	GO:0016021	integral component of membrane

0.59	EC:4.4.1.20	GO:0004464
0.59	KEGG:R03059	GO:0004464

sp|O14893|GEMI2_HUMAN
Gem-associated protein 2
Search

GEMIN2

0.95	Survival of motor neuron protein interacting protein 1

0.80	GO:0000245	spliceosomal complex assembly
0.80	GO:0000387	spliceosomal snRNP assembly
0.45	GO:0048675	axon extension
0.34	GO:0051170	nuclear import

0.33

GO:0005515

protein binding

0.75	GO:0005681	spliceosomal complex
0.59	GO:0097504	Gemini of coiled bodies
0.57	GO:0032797	SMN complex
0.57	GO:0034719	SMN-Sm protein complex
0.50	GO:0005730	nucleolus
0.48	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O14894|T4S5_HUMAN
Transmembrane 4 L6 family member 5
Search

TM4SF5

0.94	Transmembrane 4 L six family member 5

0.35

GO:0120009

intermembrane lipid transfer

0.35

GO:0120013

intermembrane lipid transfer activity

0.40	GO:0005887	integral component of plasma membrane
0.32	GO:0005737	cytoplasm

sp|O14896|IRF6_HUMAN
Interferon regulatory factor 6
Search

IRF6

0.97	Interferon regulatory factor 6

0.62	GO:0043616	keratinocyte proliferation
0.60	GO:0060644	mammary gland epithelial cell differentiation
0.59	GO:0030216	keratinocyte differentiation
0.58	GO:0007050	cell cycle arrest
0.57	GO:0006357	regulation of transcription by RNA polymerase II
0.57	GO:0008285	negative regulation of cell proliferation
0.57	GO:0006351	transcription, DNA-templated
0.55	GO:0045893	positive regulation of transcription, DNA-templated
0.54	GO:0048468	cell development
0.51	GO:0019221	cytokine-mediated signaling pathway

0.75	GO:0044212	transcription regulatory region DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.50	GO:0043565	sequence-specific DNA binding
0.39	GO:0042802	identical protein binding

0.60	GO:0005634	nucleus
0.54	GO:0030054	cell junction
0.51	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

sp|O14901|KLF11_HUMAN
Krueppel-like factor 11
Search

KLF11

0.97	Kruppel like factor 11

0.61	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
0.57	GO:0008285	negative regulation of cell proliferation
0.57	GO:0043065	positive regulation of apoptotic process
0.57	GO:0000122	negative regulation of transcription by RNA polymerase II
0.41	GO:1901653	cellular response to peptide
0.39	GO:0030097	hemopoiesis
0.37	GO:0006915	apoptotic process
0.36	GO:0006366	transcription by RNA polymerase II

0.55	GO:0044212	transcription regulatory region DNA binding
0.54	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.34	GO:0005515	protein binding
0.34	GO:0046872	metal ion binding

0.58	GO:0005925	focal adhesion
0.56	GO:0016604	nuclear body
0.51	GO:0005829	cytosol

sp|O14904|WNT9A_HUMAN
Protein Wnt-9a
Search

sp|O14905|WNT9B_HUMAN
Protein Wnt-9b
Search

sp|O14907|TX1B3_HUMAN
Tax1-binding protein 3
Search

TAX1BP3

0.97	Tax interaction protein 1

0.84	GO:2000009	negative regulation of protein localization to cell surface
0.79	GO:0007266	Rho protein signal transduction
0.79	GO:0090630	activation of GTPase activity
0.77	GO:0030178	negative regulation of Wnt signaling pathway
0.74	GO:0008285	negative regulation of cell proliferation
0.56	GO:0060028	convergent extension involved in axis elongation
0.41	GO:0016055	Wnt signaling pathway

0.78	GO:0008013	beta-catenin binding
0.77	GO:0008022	protein C-terminus binding

0.77	GO:0001650	fibrillar center
0.69	GO:0015629	actin cytoskeleton
0.47	GO:0005737	cytoplasm
0.39	GO:0070062	extracellular exosome
0.36	GO:0005886	plasma membrane

sp|O14908|GIPC1_HUMAN
PDZ domain-containing protein GIPC1
Search

GIPC1

0.96	GIPC PDZ domain containing family member 1

0.78	GO:0014047	glutamate secretion
0.75	GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus
0.74	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
0.73	GO:0043542	endothelial cell migration
0.72	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
0.72	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
0.71	GO:0048167	regulation of synaptic plasticity
0.71	GO:0032467	positive regulation of cytokinesis
0.68	GO:0031647	regulation of protein stability
0.66	GO:0007268	chemical synaptic transmission

0.72	GO:0017022	myosin binding
0.68	GO:0045296	cadherin binding
0.65	GO:0042803	protein homodimerization activity
0.63	GO:0003779	actin binding
0.62	GO:0005102	receptor binding
0.58	GO:0004707	MAP kinase activity
0.40	GO:0030165	PDZ domain binding

0.74	GO:0043198	dendritic shaft
0.72	GO:0043197	dendritic spine
0.70	GO:0008021	synaptic vesicle
0.65	GO:0012506	vesicle membrane
0.64	GO:0005938	cell cortex
0.59	GO:0005829	cytosol
0.40	GO:0005903	brush border
0.40	GO:0030139	endocytic vesicle

0.58	EC:2.7.11.24	GO:0004707
0.58	KEGG:R00162	GO:0004707

sp|O14910|LIN7A_HUMAN
Protein lin-7 homolog A
Search

LIN7A

0.96	Lin-7 homolog A, crumbs cell polarity complex component

0.82	GO:0099643	signal release from synapse
0.82	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.76	GO:0006836	neurotransmitter transport
0.76	GO:0006887	exocytosis
0.73	GO:0048489	synaptic vesicle transport
0.73	GO:0048839	inner ear development
0.72	GO:0001505	regulation of neurotransmitter levels
0.64	GO:0015031	protein transport
0.63	GO:1903361	protein localization to basolateral plasma membrane
0.62	GO:0045199	maintenance of epithelial cell apical/basal polarity

0.86	GO:0097016	L27 domain binding
0.50	GO:0008092	cytoskeletal protein binding

0.85	GO:0097025	MPP7-DLG1-LIN7 complex
0.83	GO:0016323	basolateral plasma membrane
0.79	GO:0098793	presynapse
0.61	GO:0005911	cell-cell junction
0.44	GO:0005622	intracellular

sp|O14917|PCD17_HUMAN
Protocadherin-17
Search

PCDH17

0.97	LOW QUALITY PROTEIN: protocadherin-17

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.59	GO:1904071	presynaptic active zone assembly
0.57	GO:2000807	regulation of synaptic vesicle clustering
0.55	GO:0050805	negative regulation of synaptic transmission
0.54	GO:0030534	adult behavior
0.46	GO:0060219	camera-type eye photoreceptor cell differentiation
0.46	GO:0007267	cell-cell signaling
0.41	GO:0007420	brain development

0.70	GO:0005509	calcium ion binding
0.34	GO:0005515	protein binding

0.56	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O14920|IKKB_HUMAN
Inhibitor of nuclear factor kappa-B kinase subunit beta
Search

IKBKB

0.95	Inhibitor of nuclear factor kappa-B kinase subunit beta

0.79	GO:0007252	I-kappaB phosphorylation
0.62	GO:1903347	negative regulation of bicellular tight junction assembly
0.62	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity
0.61	GO:1903140	regulation of establishment of endothelial barrier
0.60	GO:0070498	interleukin-1-mediated signaling pathway
0.60	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.58	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.57	GO:0018105	peptidyl-serine phosphorylation
0.57	GO:0072659	protein localization to plasma membrane
0.57	GO:0030866	cortical actin cytoskeleton organization

0.81	GO:0008384	IkappaB kinase activity
0.60	GO:0097110	scaffold protein binding
0.55	GO:0019901	protein kinase binding
0.54	GO:0042803	protein homodimerization activity
0.53	GO:0030554	adenyl nucleotide binding
0.53	GO:0046982	protein heterodimerization activity
0.52	GO:0097367	carbohydrate derivative binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity

0.51	GO:0005829	cytosol
0.47	GO:1902554	serine/threonine protein kinase complex
0.40	GO:0035631	CD40 receptor complex
0.39	GO:0098857	membrane microdomain
0.37	GO:0009898	cytoplasmic side of plasma membrane
0.37	GO:0005634	nucleus
0.34	GO:0070013	intracellular organelle lumen
0.33	GO:0005783	endoplasmic reticulum
0.33	GO:0044446	intracellular organelle part

0.81

EC:2.7.11.10

GO:0008384

sp|O14921|RGS13_HUMAN
Regulator of G-protein signaling 13
Search

RGS13

0.93	Regulator of G-protein signaling 1

0.73	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.66	GO:0007186	G-protein coupled receptor signaling pathway
0.63	GO:0043547	positive regulation of GTPase activity
0.57	GO:0009968	negative regulation of signal transduction
0.45	GO:0035556	intracellular signal transduction
0.34	GO:0097503	sialylation
0.34	GO:0035023	regulation of Rho protein signal transduction
0.34	GO:0043413	macromolecule glycosylation
0.34	GO:0009101	glycoprotein biosynthetic process
0.33	GO:0036211	protein modification process

0.63	GO:0005096	GTPase activator activity
0.51	GO:0001965	G-protein alpha-subunit binding
0.49	GO:0004871	signal transducer activity
0.46	GO:0031681	G-protein beta-subunit binding
0.45	GO:0005092	GDP-dissociation inhibitor activity
0.34	GO:0008373	sialyltransferase activity
0.34	GO:0005089	Rho guanyl-nucleotide exchange factor activity

0.58	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.56	GO:0005829	cytosol
0.55	GO:1905360	GTPase complex
0.49	GO:0005634	nucleus
0.48	GO:0098797	plasma membrane protein complex
0.33	GO:0005938	cell cortex
0.30	GO:0016021	integral component of membrane

0.34

GO:0008373

sp|O14924|RGS12_HUMAN
Regulator of G-protein signaling 12
Search

RGS12

0.95	Regulator of G-protein signalling 12

0.67	GO:0050790	regulation of catalytic activity
0.59	GO:0007165	signal transduction
0.43	GO:0044093	positive regulation of molecular function
0.39	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.37	GO:0009968	negative regulation of signal transduction
0.34	GO:0006351	transcription, DNA-templated

0.77	GO:0005057	signal transducer activity, downstream of receptor
0.74	GO:0030695	GTPase regulator activity
0.44	GO:0008047	enzyme activator activity
0.36	GO:0001965	G-protein alpha-subunit binding

0.50	GO:0005730	nucleolus
0.48	GO:0005829	cytosol
0.40	GO:0030425	dendrite
0.39	GO:0045202	synapse
0.38	GO:0030054	cell junction
0.38	GO:0005886	plasma membrane
0.37	GO:0016363	nuclear matrix
0.36	GO:0000794	condensed nuclear chromosome
0.36	GO:0043025	neuronal cell body
0.33	GO:0043234	protein complex

sp|O14925|TIM23_HUMAN
Mitochondrial import inner membrane translocase subunit Tim23
Search

TIMM23

0.86	Translocase of inner mitochondrial membrane 23 homolog B

0.66	GO:0071806	protein transmembrane transport
0.65	GO:0006886	intracellular protein transport
0.47	GO:1990542	mitochondrial transmembrane transport
0.47	GO:0072655	establishment of protein localization to mitochondrion
0.46	GO:0007005	mitochondrion organization
0.45	GO:0017038	protein import
0.36	GO:1905242	response to 3,3',5-triiodo-L-thyronine
0.35	GO:0010954	positive regulation of protein processing
0.34	GO:0090150	establishment of protein localization to membrane
0.33	GO:0007275	multicellular organism development

0.70	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
0.35	GO:0005515	protein binding

0.76	GO:0005744	mitochondrial inner membrane presequence translocase complex
0.50	GO:0031305	integral component of mitochondrial inner membrane
0.44	GO:0005758	mitochondrial intermembrane space
0.33	GO:1990351	transporter complex
0.33	GO:0016272	prefoldin complex

sp|O14926|FSCN2_HUMAN
Fascin-2
Search

FSCN2

0.57	Fascin actin-bundling protein 1

0.75	GO:0007015	actin filament organization
0.62	GO:0016477	cell migration
0.55	GO:0007163	establishment or maintenance of cell polarity
0.53	GO:0030035	microspike assembly
0.52	GO:0032534	regulation of microvillus assembly
0.52	GO:0090091	positive regulation of extracellular matrix disassembly
0.52	GO:0071803	positive regulation of podosome assembly
0.51	GO:0010592	positive regulation of lamellipodium assembly
0.51	GO:0042462	eye photoreceptor cell development
0.51	GO:0051491	positive regulation of filopodium assembly

0.80	GO:0030674	protein binding, bridging
0.78	GO:0051015	actin filament binding
0.48	GO:0045296	cadherin binding
0.39	GO:0008144	drug binding
0.33	GO:0003723	RNA binding

0.65	GO:0005856	cytoskeleton
0.58	GO:0098858	actin-based cell projection
0.55	GO:0043005	neuron projection
0.53	GO:0044393	microspike
0.51	GO:0071437	invadopodium
0.51	GO:0032421	stereocilium bundle
0.50	GO:0001726	ruffle
0.49	GO:0031253	cell projection membrane
0.49	GO:0030027	lamellipodium
0.48	GO:0030427	site of polarized growth

sp|O14929|HAT1_HUMAN
Histone acetyltransferase type B catalytic subunit
Search

HAT1

0.75	Histone acetyltransferase type B catalytic subunit

0.82	GO:0006348	chromatin silencing at telomere
0.77	GO:0016573	histone acetylation
0.58	GO:0006335	DNA replication-dependent nucleosome assembly
0.56	GO:0006336	DNA replication-independent nucleosome assembly
0.38	GO:0007584	response to nutrient

0.79	GO:0004402	histone acetyltransferase activity
0.79	GO:0042393	histone binding
0.33	GO:0008483	transaminase activity

0.78	GO:0000781	chromosome, telomeric region
0.61	GO:0005634	nucleus
0.51	GO:0000785	chromatin
0.49	GO:0031974	membrane-enclosed lumen
0.44	GO:0043234	protein complex
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.79

GO:0004402

sp|O14931|NCTR3_HUMAN
Natural cytotoxicity triggering receptor 3
Search

NCR3

0.97	Natural cytotoxicity triggering receptor 3

0.80	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
0.80	GO:0030101	natural killer cell activation
0.76	GO:0002429	immune response-activating cell surface receptor signaling pathway
0.64	GO:0060370	susceptibility to T cell mediated cytotoxicity
0.62	GO:0002857	positive regulation of natural killer cell mediated immune response to tumor cell
0.62	GO:0002858	regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
0.59	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
0.56	GO:0008037	cell recognition
0.55	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.42	GO:0006955	immune response

0.67	GO:0042802	identical protein binding
0.56	GO:0050839	cell adhesion molecule binding
0.53	GO:0005102	receptor binding
0.50	GO:0046983	protein dimerization activity
0.48	GO:0004872	receptor activity
0.38	GO:0030545	receptor regulator activity

0.58	GO:0005913	cell-cell adherens junction
0.49	GO:0005887	integral component of plasma membrane
0.38	GO:0005615	extracellular space

sp|O14933|UB2L6_HUMAN
Ubiquitin/ISG15-conjugating enzyme E2 L6
Search

UBE2L6

0.88	Ubiquitin-conjugating enzyme E2 L3 (inferred by orthology to a human protein)

0.58	GO:0032020	ISG15-protein conjugation
0.52	GO:0019941	modification-dependent protein catabolic process
0.42	GO:0016567	protein ubiquitination
0.37	GO:0036503	ERAD pathway
0.36	GO:0016050	vesicle organization
0.36	GO:0032480	negative regulation of type I interferon production
0.36	GO:0019985	translesion synthesis
0.33	GO:0009226	nucleotide-sugar biosynthetic process
0.32	GO:0055114	oxidation-reduction process

0.59	GO:0042296	ISG15 transferase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0004842	ubiquitin-protein transferase activity
0.39	GO:0031625	ubiquitin protein ligase binding
0.39	GO:0061659	ubiquitin-like protein ligase activity
0.38	GO:0043130	ubiquitin binding
0.34	GO:0016874	ligase activity
0.32	GO:0050662	coenzyme binding

0.36	GO:1905369	endopeptidase complex
0.35	GO:0005829	cytosol
0.34	GO:0005654	nucleoplasm
0.34	GO:0043234	protein complex
0.32	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

0.34	EC:6	GO:0016874
0.41	KEGG:R03876	GO:0004842

sp|O14936|CSKP_HUMAN
Peripheral plasma membrane protein CASK
Search

CASK

0.80	Calcium/calmodulin-dependent serine protein kinase a

0.63	GO:0006468	protein phosphorylation
0.57	GO:0010839	negative regulation of keratinocyte proliferation
0.56	GO:0001953	negative regulation of cell-matrix adhesion
0.55	GO:0061045	negative regulation of wound healing
0.54	GO:0090280	positive regulation of calcium ion import
0.53	GO:0090288	negative regulation of cellular response to growth factor stimulus
0.53	GO:0070509	calcium ion import
0.49	GO:0045944	positive regulation of transcription by RNA polymerase II

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0042043	neurexin family protein binding

0.56	GO:0005652	nuclear lamina
0.54	GO:0016363	nuclear matrix
0.53	GO:0005604	basement membrane
0.52	GO:0016323	basolateral plasma membrane
0.51	GO:0005911	cell-cell junction
0.49	GO:0005730	nucleolus
0.49	GO:0045202	synapse
0.47	GO:0031982	vesicle
0.46	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O14939|PLD2_HUMAN
Phospholipase D2
Search

PLD2

0.52	Phospholipase

0.81	GO:0006654	phosphatidic acid biosynthetic process
0.80	GO:0048017	inositol lipid-mediated signaling
0.69	GO:0016042	lipid catabolic process
0.48	GO:0036465	synaptic vesicle recycling
0.44	GO:0048870	cell motility
0.41	GO:0032534	regulation of microvillus assembly
0.39	GO:0002031	G-protein coupled receptor internalization
0.39	GO:0001525	angiogenesis
0.38	GO:0050778	positive regulation of immune response
0.37	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis

0.83	GO:0004630	phospholipase D activity
0.78	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity
0.75	GO:0035091	phosphatidylinositol binding
0.36	GO:0005080	protein kinase C binding

0.46	GO:0098793	presynapse
0.45	GO:0005794	Golgi apparatus
0.40	GO:0098590	plasma membrane region
0.38	GO:0005903	brush border
0.37	GO:0030139	endocytic vesicle
0.37	GO:0045177	apical part of cell
0.37	GO:0120038	plasma membrane bounded cell projection part
0.37	GO:0005789	endoplasmic reticulum membrane
0.36	GO:0005768	endosome
0.36	GO:0042383	sarcolemma

0.83

EC:3.1.4.4

GO:0004630

sp|O14944|EREG_HUMAN
Proepiregulin
Search

EREG

0.97	Proepiregulin

0.55	GO:0007173	epidermal growth factor receptor signaling pathway
0.54	GO:0051151	negative regulation of smooth muscle cell differentiation
0.54	GO:0043616	keratinocyte proliferation
0.54	GO:0045410	positive regulation of interleukin-6 biosynthetic process
0.53	GO:0009299	mRNA transcription
0.53	GO:0048146	positive regulation of fibroblast proliferation
0.52	GO:0045740	positive regulation of DNA replication
0.52	GO:0045840	positive regulation of mitotic nuclear division
0.52	GO:0048160	primary follicle stage
0.50	GO:0045089	positive regulation of innate immune response

0.55	GO:0005154	epidermal growth factor receptor binding
0.48	GO:0008083	growth factor activity
0.42	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.39	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.39	GO:0004713	protein tyrosine kinase activity

0.49	GO:0005615	extracellular space
0.38	GO:0005886	plasma membrane
0.33	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

0.42	EC:2.7.1.153	GO:0046934
0.42	KEGG:R04545	GO:0046934

sp|O14948|TFEC_HUMAN
Transcription factor EC
Search

TFEC

0.97	Transcription factor EC

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.52	GO:0034605	cellular response to heat
0.44	GO:0061484	hematopoietic stem cell homeostasis
0.44	GO:0071425	hematopoietic stem cell proliferation
0.43	GO:0060216	definitive hemopoiesis
0.37	GO:0006351	transcription, DNA-templated
0.36	GO:0051254	positive regulation of RNA metabolic process
0.36	GO:0010557	positive regulation of macromolecule biosynthetic process

0.68	GO:0046983	protein dimerization activity
0.38	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.37	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0003714	transcription corepressor activity
0.35	GO:0003713	transcription coactivator activity

0.48

GO:0005654

nucleoplasm

sp|O14949|QCR8_HUMAN
Cytochrome b-c1 complex subunit 8
Search

UQCRQ

0.93	Mitochondrial ubiquinol-cytochrome c reductase ubiquinone-binding protein qp-c

0.62	GO:0021539	subthalamus development
0.61	GO:0022900	electron transport chain
0.61	GO:0021860	pyramidal neuron development
0.60	GO:0021794	thalamus development
0.59	GO:0021548	pons development
0.59	GO:0021854	hypothalamus development
0.58	GO:0021680	cerebellar Purkinje cell layer development
0.58	GO:0030901	midbrain development
0.58	GO:0021766	hippocampus development
0.42	GO:0006119	oxidative phosphorylation

0.74	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
0.62	GO:0009055	electron transfer activity
0.37	GO:0005230	extracellular ligand-gated ion channel activity
0.36	GO:0004888	transmembrane signaling receptor activity
0.35	GO:0048039	ubiquinone binding
0.33	GO:0005515	protein binding

0.49	GO:0005750	mitochondrial respiratory chain complex III
0.34	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.74

EC:1.10.2

GO:0016681

sp|O14950|ML12B_HUMAN
Myosin regulatory light chain 12B
Search

MYL12B

0.89	Myosin regulatory light chain

0.48	GO:0008360	regulation of cell shape
0.45	GO:0072659	protein localization to plasma membrane
0.36	GO:0070527	platelet aggregation
0.36	GO:0006936	muscle contraction
0.34	GO:0048013	ephrin receptor signaling pathway
0.34	GO:0031032	actomyosin structure organization

0.68	GO:0005509	calcium ion binding
0.53	GO:0032036	myosin heavy chain binding
0.46	GO:0035254	glutamate receptor binding
0.35	GO:0030898	actin-dependent ATPase activity
0.34	GO:0051015	actin filament binding
0.34	GO:0051020	GTPase binding
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.57	GO:0016460	myosin II complex
0.56	GO:0097517	contractile actin filament bundle
0.56	GO:0042641	actomyosin
0.55	GO:0030018	Z disc
0.50	GO:0005903	brush border
0.50	GO:0099738	cell cortex region
0.49	GO:0045177	apical part of cell
0.37	GO:0070062	extracellular exosome
0.35	GO:0097513	myosin II filament
0.34	GO:0005829	cytosol

sp|O14957|QCR10_HUMAN
Cytochrome b-c1 complex subunit 10
Search

0.96	Ubiquinol-cytochrome c reductase subunit

0.61	GO:0022900	electron transport chain
0.35	GO:0006119	oxidative phosphorylation
0.35	GO:0045333	cellular respiration

0.74	GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
0.62	GO:0009055	electron transfer activity
0.38	GO:0008327	methyl-CpG binding
0.34	GO:0046983	protein dimerization activity

0.49	GO:0031966	mitochondrial membrane
0.49	GO:0019866	organelle inner membrane
0.38	GO:0090545	CHD-type complex
0.38	GO:0070469	respiratory chain
0.37	GO:0090568	nuclear transcriptional repressor complex
0.37	GO:0000118	histone deacetylase complex
0.30	GO:0016021	integral component of membrane

0.74

EC:1.10.2

GO:0016681

sp|O14958|CASQ2_HUMAN
Calsequestrin-2
Search

CASQ2

0.91	Calsequestrin

0.59	GO:0051208	sequestering of calcium ion
0.58	GO:0071313	cellular response to caffeine
0.58	GO:0010649	regulation of cell communication by electrical coupling
0.58	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
0.58	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
0.57	GO:1901017	negative regulation of potassium ion transmembrane transporter activity
0.56	GO:0060306	regulation of membrane repolarization
0.55	GO:0060048	cardiac muscle contraction
0.55	GO:0045214	sarcomere organization
0.55	GO:0002027	regulation of heart rate

0.70	GO:0005509	calcium ion binding
0.56	GO:0048306	calcium-dependent protein binding
0.36	GO:0042802	identical protein binding
0.35	GO:0005080	protein kinase C binding
0.35	GO:0046983	protein dimerization activity
0.32	GO:0016887	ATPase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0008144	drug binding

0.60	GO:0033018	sarcoplasmic reticulum lumen
0.57	GO:0030314	junctional membrane complex
0.54	GO:0030018	Z disc
0.40	GO:0014802	terminal cisterna
0.36	GO:0005891	voltage-gated calcium channel complex
0.36	GO:0014701	junctional sarcoplasmic reticulum membrane
0.34	GO:0005759	mitochondrial matrix

0.32

GO:0016887

sp|O14960|LECT2_HUMAN
Leukocyte cell-derived chemotaxin-2
Search

LECT2

0.96	Leukocyte cell-derived chemotaxin-2

0.44	GO:0030178	negative regulation of Wnt signaling pathway
0.44	GO:0006935	chemotaxis
0.41	GO:0001501	skeletal system development

0.74	GO:0042802	identical protein binding
0.38	GO:0046872	metal ion binding

0.43	GO:0005576	extracellular region
0.34	GO:0005737	cytoplasm

sp|O14964|HGS_HUMAN
Hepatocyte growth factor-regulated tyrosine kinase substrate
Search

HGS

0.90	Hepatocyte growth factor-regulated tyrosine kinase substrate

0.67	GO:0006886	intracellular protein transport
0.60	GO:1903543	positive regulation of exosomal secretion
0.59	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
0.59	GO:0061462	protein localization to lysosome
0.58	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
0.58	GO:0046426	negative regulation of JAK-STAT cascade
0.57	GO:0010324	membrane invagination
0.57	GO:0007041	lysosomal transport
0.56	GO:0072666	establishment of protein localization to vacuole
0.56	GO:0016525	negative regulation of angiogenesis

0.62	GO:0019904	protein domain specific binding
0.54	GO:0044389	ubiquitin-like protein ligase binding
0.53	GO:0046872	metal ion binding
0.52	GO:0016301	kinase activity
0.38	GO:0140036	ubiquitin-dependent protein binding
0.36	GO:0042802	identical protein binding
0.35	GO:0003735	structural constituent of ribosome

0.69	GO:0032585	multivesicular body membrane
0.66	GO:0031901	early endosome membrane
0.60	GO:0033565	ESCRT-0 complex
0.57	GO:0005829	cytosol
0.54	GO:0005764	lysosome
0.37	GO:0070062	extracellular exosome
0.35	GO:0030141	secretory granule
0.34	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

sp|O14965|AURKA_HUMAN
Aurora kinase A
Search

AURKA

0.93	Aurora kinase A-B

0.71	GO:0007100	mitotic centrosome separation
0.69	GO:0000212	meiotic spindle organization
0.67	GO:0007052	mitotic spindle organization
0.63	GO:0006468	protein phosphorylation
0.61	GO:1900195	positive regulation of oocyte maturation
0.58	GO:0097421	liver regeneration
0.58	GO:0007144	female meiosis I
0.57	GO:0018209	peptidyl-serine modification
0.57	GO:0051642	centrosome localization
0.57	GO:0071539	protein localization to centrosome

0.68	GO:0004674	protein serine/threonine kinase activity
0.60	GO:0035173	histone kinase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.53	GO:0031625	ubiquitin protein ligase binding
0.53	GO:0019901	protein kinase binding
0.51	GO:0046982	protein heterodimerization activity
0.46	GO:0004712	protein serine/threonine/tyrosine kinase activity

0.60	GO:0031616	spindle pole centrosome
0.59	GO:0042585	germinal vesicle
0.59	GO:0043203	axon hillock
0.57	GO:0045120	pronucleus
0.57	GO:0097431	mitotic spindle pole
0.57	GO:0005876	spindle microtubule
0.57	GO:0072687	meiotic spindle
0.53	GO:0048471	perinuclear region of cytoplasm
0.50	GO:0032133	chromosome passenger complex
0.49	GO:0005829	cytosol

0.68

GO:0004674

sp|O14966|RAB7L_HUMAN
Ras-related protein Rab-7L1
Search

RAB29

0.97	RAB29, member RAS oncogene family

0.68	GO:0016192	vesicle-mediated transport
0.60	GO:1990967	multi-organism toxin transport
0.58	GO:0001921	positive regulation of receptor recycling
0.57	GO:0050862	positive regulation of T cell receptor signaling pathway
0.55	GO:0010977	negative regulation of neuron projection development
0.55	GO:0007416	synapse assembly
0.54	GO:0090316	positive regulation of intracellular protein transport
0.54	GO:0042110	T cell activation
0.54	GO:0007030	Golgi organization
0.54	GO:0016197	endosomal transport

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.56	GO:0019003	GDP binding
0.55	GO:0019894	kinesin binding
0.55	GO:0070840	dynein complex binding
0.53	GO:0017137	Rab GTPase binding
0.43	GO:0036461	BLOC-2 complex binding
0.43	GO:0035651	AP-3 adaptor complex binding
0.42	GO:0035650	AP-1 adaptor complex binding
0.42	GO:0030742	GTP-dependent protein binding

0.78	GO:0005802	trans-Golgi network
0.71	GO:0031982	vesicle
0.58	GO:0020003	symbiont-containing vacuole
0.54	GO:0005801	cis-Golgi network
0.48	GO:0005829	cytosol
0.46	GO:0005739	mitochondrion
0.41	GO:0044233	ER-mitochondrion membrane contact site
0.40	GO:0005764	lysosome
0.38	GO:0048471	perinuclear region of cytoplasm
0.38	GO:0098805	whole membrane

sp|O14967|CLGN_HUMAN
Calmegin
Search

CLGN

0.81	Testis tissue sperm-binding protein Li 79P

0.69	GO:0006457	protein folding
0.54	GO:0007339	binding of sperm to zona pellucida
0.46	GO:0006461	protein complex assembly
0.43	GO:0048488	synaptic vesicle endocytosis
0.40	GO:0072583	clathrin-dependent endocytosis
0.37	GO:0048916	posterior lateral line development
0.35	GO:0001503	ossification
0.35	GO:0005975	carbohydrate metabolic process
0.34	GO:0007155	cell adhesion
0.34	GO:0007283	spermatogenesis

0.71	GO:0051082	unfolded protein binding
0.70	GO:0005509	calcium ion binding
0.53	GO:0044183	protein binding involved in protein folding
0.36	GO:0016758	transferase activity, transferring hexosyl groups
0.33	GO:0003777	microtubule motor activity
0.33	GO:0030246	carbohydrate binding

0.70	GO:0005783	endoplasmic reticulum
0.49	GO:0005635	nuclear envelope
0.44	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.43	GO:0031984	organelle subcompartment
0.41	GO:0044233	ER-mitochondrion membrane contact site
0.41	GO:0043209	myelin sheath
0.40	GO:0045202	synapse
0.34	GO:0042470	melanosome
0.34	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

0.36

GO:0016758

sp|O14972|DSCR3_HUMAN
Down syndrome critical region protein 3
Search

DSCR3

0.91	Down syndrome critical region protein A

0.60	GO:0007165	signal transduction
0.38	GO:0006886	intracellular protein transport

0.38

GO:0008565

protein transporter activity

0.39	GO:0005768	endosome
0.35	GO:0005634	nucleus

sp|O14974|MYPT1_HUMAN
Protein phosphatase 1 regulatory subunit 12A
Search

PPP1R12A

0.92	Phosphatase 1 regulatory subunit 12A

0.67	GO:0050790	regulation of catalytic activity
0.59	GO:0007165	signal transduction
0.57	GO:0035307	positive regulation of protein dephosphorylation
0.56	GO:0007098	centrosome cycle
0.55	GO:0046822	regulation of nucleocytoplasmic transport
0.55	GO:0035690	cellular response to drug
0.53	GO:0030155	regulation of cell adhesion
0.52	GO:0045944	positive regulation of transcription by RNA polymerase II
0.52	GO:0000278	mitotic cell cycle
0.51	GO:0044093	positive regulation of molecular function

0.77	GO:0019208	phosphatase regulator activity
0.76	GO:0019901	protein kinase binding
0.60	GO:0071889	14-3-3 protein binding
0.52	GO:0004857	enzyme inhibitor activity
0.34	GO:0004721	phosphoprotein phosphatase activity
0.34	GO:0004871	signal transducer activity
0.34	GO:0046982	protein heterodimerization activity

0.58	GO:0031672	A band
0.58	GO:0072357	PTW/PP1 phosphatase complex
0.56	GO:0030018	Z disc
0.54	GO:0000776	kinetochore
0.54	GO:0005813	centrosome
0.51	GO:0015629	actin cytoskeleton
0.49	GO:0005829	cytosol
0.37	GO:0005925	focal adhesion
0.34	GO:0005654	nucleoplasm
0.30	GO:0016021	integral component of membrane

0.34

GO:0004721

sp|O14975|S27A2_HUMAN
Very long-chain acyl-CoA synthetase
Search

SLC27A2

0.89	Very long-chain acyl-CoA synthetase

0.73	GO:0015908	fatty acid transport
0.71	GO:0001676	long-chain fatty acid metabolic process
0.65	GO:0006699	bile acid biosynthetic process
0.60	GO:0097089	methyl-branched fatty acid metabolic process
0.58	GO:0001561	fatty acid alpha-oxidation
0.56	GO:0042760	very long-chain fatty acid catabolic process
0.52	GO:0006635	fatty acid beta-oxidation
0.36	GO:0043312	neutrophil degranulation

0.78	GO:0031957	very long-chain fatty acid-CoA ligase activity
0.72	GO:0004467	long-chain fatty acid-CoA ligase activity
0.63	GO:0015245	fatty acid transmembrane transporter activity
0.61	GO:0070251	pristanate-CoA ligase activity
0.61	GO:0050197	phytanate-CoA ligase activity
0.50	GO:0005102	receptor binding
0.49	GO:0019899	enzyme binding
0.38	GO:0102391	decanoate--CoA ligase activity
0.34	GO:0030554	adenyl nucleotide binding
0.34	GO:0032555	purine ribonucleotide binding

0.55	GO:0005788	endoplasmic reticulum lumen
0.53	GO:0005779	integral component of peroxisomal membrane
0.52	GO:0030176	integral component of endoplasmic reticulum membrane
0.44	GO:0005739	mitochondrion
0.37	GO:0070062	extracellular exosome
0.36	GO:0035579	specific granule membrane
0.33	GO:0005886	plasma membrane

0.72	EC:6.2.1.3	GO:0004467
0.61	KEGG:R03631	GO:0050197

sp|O14976|GAK_HUMAN
Cyclin-G-associated kinase
Search

GAK

0.93	Cyclin-G-associated kinase

0.62	GO:0006468	protein phosphorylation
0.61	GO:1905224	clathrin-coated pit assembly
0.59	GO:0072318	clathrin coat disassembly
0.58	GO:0090160	Golgi to lysosome transport
0.57	GO:0072600	establishment of protein localization to Golgi
0.55	GO:0010977	negative regulation of neuron projection development
0.55	GO:0072659	protein localization to plasma membrane
0.54	GO:0007030	Golgi organization
0.51	GO:0006898	receptor-mediated endocytosis
0.39	GO:0007029	endoplasmic reticulum organization

0.63	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0030332	cyclin binding
0.35	GO:0051087	chaperone binding

0.51	GO:0031982	vesicle
0.50	GO:0005829	cytosol
0.49	GO:0005794	Golgi apparatus
0.44	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0005925	focal adhesion
0.35	GO:0045202	synapse
0.30	GO:0016020	membrane

sp|O14977|AZIN1_HUMAN
Antizyme inhibitor 1
Search

AZIN1

0.97	Antizyme inhibitor 1

0.69	GO:0006596	polyamine biosynthetic process
0.67	GO:0043085	positive regulation of catalytic activity
0.53	GO:1902269	positive regulation of polyamine transmembrane transport
0.50	GO:0042177	negative regulation of protein catabolic process
0.44	GO:0009445	putrescine metabolic process
0.43	GO:0006591	ornithine metabolic process
0.35	GO:0006521	regulation of cellular amino acid metabolic process

0.82	GO:0042978	ornithine decarboxylase activator activity
0.43	GO:0004586	ornithine decarboxylase activity
0.33	GO:0005515	protein binding

0.43	GO:0005634	nucleus
0.35	GO:0005737	cytoplasm

0.43	EC:4.1.1.17	GO:0004586
0.43	KEGG:R00670	GO:0004586

sp|O14978|ZN263_HUMAN
Zinc finger protein 263
Search

ZSCAN25

0.80	Zinc finger protein with KRAB and SCAN domains 13

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:0006351	transcription, DNA-templated
0.48	GO:1902679	negative regulation of RNA biosynthetic process
0.41	GO:1902680	positive regulation of RNA biosynthetic process
0.41	GO:0042035	regulation of cytokine biosynthetic process
0.39	GO:2000773	negative regulation of cellular senescence
0.38	GO:0007040	lysosome organization
0.37	GO:0010507	negative regulation of autophagy

0.60	GO:0003700	DNA binding transcription factor activity
0.51	GO:0046872	metal ion binding
0.50	GO:0003676	nucleic acid binding
0.38	GO:0042802	identical protein binding
0.37	GO:0003682	chromatin binding

0.60	GO:0005634	nucleus
0.39	GO:0005829	cytosol
0.39	GO:0043233	organelle lumen
0.37	GO:0044446	intracellular organelle part

sp|O14979|HNRDL_HUMAN
Heterogeneous nuclear ribonucleoprotein D-like
Search

HNRNPDL

0.94	Heterogeneous nuclear ribonucleoprotein D like

0.39	GO:1905663	positive regulation of telomerase RNA reverse transcriptase activity
0.39	GO:0097167	circadian regulation of translation
0.38	GO:1904355	positive regulation of telomere capping
0.38	GO:0043488	regulation of mRNA stability
0.37	GO:0042752	regulation of circadian rhythm
0.37	GO:0035722	interleukin-12-mediated signaling pathway
0.37	GO:2001141	regulation of RNA biosynthetic process
0.37	GO:0006351	transcription, DNA-templated
0.37	GO:0045727	positive regulation of translation
0.34	GO:0001837	epithelial to mesenchymal transition

0.58	GO:0003723	RNA binding
0.37	GO:0003697	single-stranded DNA binding
0.37	GO:0042162	telomeric DNA binding
0.37	GO:0003690	double-stranded DNA binding
0.35	GO:0005515	protein binding
0.33	GO:0003700	DNA binding transcription factor activity

0.61	GO:0019013	viral nucleocapsid
0.54	GO:0030529	intracellular ribonucleoprotein complex
0.51	GO:0005654	nucleoplasm
0.37	GO:0070062	extracellular exosome
0.35	GO:0005737	cytoplasm
0.34	GO:0090575	RNA polymerase II transcription factor complex

sp|O14980|XPO1_HUMAN
Exportin-1
Search

XPO1

0.86	Exportin-1

0.67	GO:0006886	intracellular protein transport
0.57	GO:0006611	protein export from nucleus
0.56	GO:0046825	regulation of protein export from nucleus
0.55	GO:0033750	ribosome localization
0.54	GO:0071166	ribonucleoprotein complex localization
0.54	GO:0051169	nuclear transport
0.53	GO:0051656	establishment of organelle localization
0.53	GO:0010824	regulation of centrosome duplication
0.51	GO:0051236	establishment of RNA localization
0.51	GO:0050657	nucleic acid transport

0.77	GO:0008536	Ran GTPase binding
0.58	GO:0005049	nuclear export signal receptor activity
0.47	GO:0008565	protein transporter activity
0.37	GO:0019904	protein domain specific binding
0.36	GO:0005487	structural constituent of nuclear pore
0.34	GO:0003723	RNA binding
0.34	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity

0.60	GO:0005634	nucleus
0.57	GO:0005642	annulate lamellae
0.51	GO:0000776	kinetochore
0.47	GO:0005829	cytosol
0.46	GO:0031974	membrane-enclosed lumen
0.44	GO:0031967	organelle envelope
0.43	GO:0031090	organelle membrane
0.43	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0044216	other organism cell
0.33	GO:0018995	host

0.34

GO:0036459

sp|O14981|BTAF1_HUMAN
TATA-binding protein-associated factor 172
Search

BTAF1

0.78	TATA-binding protein-associated factor

0.78

GO:0035562

negative regulation of chromatin binding

0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0016787	hydrolase activity

0.61	GO:0005654	nucleoplasm
0.30	GO:0044425	membrane part

0.33

GO:0016787

sp|O14983|AT2A1_HUMAN
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Search

ATP2A1

0.56	Calcium-transporting ATPase

0.76	GO:0070588	calcium ion transmembrane transport
0.68	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.57	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration
0.56	GO:0090257	regulation of muscle system process
0.54	GO:0090076	relaxation of skeletal muscle
0.52	GO:0051659	maintenance of mitochondrion location
0.51	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
0.51	GO:0051561	positive regulation of mitochondrial calcium ion concentration
0.50	GO:0070509	calcium ion import
0.50	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

0.79	GO:0005388	calcium-transporting ATPase activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0005509	calcium ion binding
0.45	GO:0042803	protein homodimerization activity
0.45	GO:0044548	S100 protein binding
0.41	GO:0019899	enzyme binding
0.39	GO:0031775	lutropin-choriogonadotropic hormone receptor binding

0.57	GO:0016529	sarcoplasmic reticulum
0.50	GO:0005789	endoplasmic reticulum membrane
0.47	GO:0098588	bounding membrane of organelle
0.46	GO:0031673	H zone
0.46	GO:0097470	ribbon synapse
0.44	GO:0048471	perinuclear region of cytoplasm
0.43	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.43	GO:0031674	I band
0.40	GO:0005739	mitochondrion
0.40	GO:0005654	nucleoplasm

0.79

EC:3.6.3.8

GO:0005388

sp|O14986|PI51B_HUMAN
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Search

PIP5K1B

0.97	Phosphatidylinositol-4-phosphate 5-kinase type 1 beta

0.75	GO:0046854	phosphatidylinositol phosphorylation
0.58	GO:0006661	phosphatidylinositol biosynthetic process
0.36	GO:0016226	iron-sulfur cluster assembly
0.33	GO:0055114	oxidation-reduction process

0.82	GO:0016307	phosphatidylinositol phosphate kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0016724	oxidoreductase activity, oxidizing metal ions, oxygen as acceptor
0.36	GO:0008199	ferric iron binding

0.67	GO:0001931	uropod
0.52	GO:0005829	cytosol
0.34	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

0.82

GO:0016307

sp|O14990|IPP4_HUMAN
Putative type-1 protein phosphatase inhibitor 4
Search

PPP1R2

0.92	Type-1 protein phosphatase inhibitor 4

0.83	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.70	GO:0009966	regulation of signal transduction
0.39	GO:0005977	glycogen metabolic process
0.35	GO:0006470	protein dephosphorylation
0.35	GO:0032091	negative regulation of protein binding
0.34	GO:0007568	aging
0.33	GO:0006869	lipid transport

0.83	GO:0004864	protein phosphatase inhibitor activity
0.35	GO:0005515	protein binding
0.35	GO:0004721	phosphoprotein phosphatase activity
0.34	GO:0031409	pigment binding
0.33	GO:0008289	lipid binding

0.52	GO:0000164	protein phosphatase type 1 complex
0.35	GO:0098723	skeletal muscle myofibril
0.35	GO:0043197	dendritic spine
0.35	GO:0030426	growth cone
0.30	GO:0016020	membrane

0.35

GO:0004721

sp|O14994|SYN3_HUMAN
Synapsin-3
Search

SYN3

0.94	Synapsin IIIa

0.82	GO:0099643	signal release from synapse
0.82	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.76	GO:0006836	neurotransmitter transport
0.72	GO:0001505	regulation of neurotransmitter levels
0.69	GO:0051649	establishment of localization in cell
0.37	GO:0032228	regulation of synaptic transmission, GABAergic

0.50	GO:0030554	adenyl nucleotide binding
0.49	GO:0032555	purine ribonucleotide binding
0.49	GO:0008144	drug binding
0.49	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding

0.82	GO:0008021	synaptic vesicle
0.58	GO:0099501	exocytic vesicle membrane
0.57	GO:0014069	postsynaptic density
0.39	GO:0030054	cell junction

sp|O15013|ARHGA_HUMAN
Rho guanine nucleotide exchange factor 10
Search

ARHGEF10

0.96	Rho guanine nucleotide exchange factor 10

0.85	GO:0022011	myelination in peripheral nervous system
0.83	GO:0090307	mitotic spindle assembly
0.76	GO:0035023	regulation of Rho protein signal transduction
0.65	GO:0065009	regulation of molecular function
0.57	GO:0051496	positive regulation of stress fiber assembly
0.56	GO:0051298	centrosome duplication

0.76	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.57	GO:0019894	kinesin binding

0.76	GO:0005813	centrosome
0.67	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O15014|ZN609_HUMAN
Zinc finger protein 609
Search

ZNF609

0.67	Zinc finger protein 609

0.63	GO:2000291	regulation of myoblast proliferation
0.62	GO:2001224	positive regulation of neuron migration
0.54	GO:0045944	positive regulation of transcription by RNA polymerase II
0.38	GO:0007517	muscle organ development
0.37	GO:0033089	positive regulation of T cell differentiation in thymus
0.34	GO:0006351	transcription, DNA-templated
0.34	GO:0043086	negative regulation of catalytic activity

0.50	GO:0003676	nucleic acid binding
0.36	GO:0008073	ornithine decarboxylase inhibitor activity
0.34	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.59

GO:0032039

integrator complex

sp|O15015|ZN646_HUMAN
Zinc finger protein 646
Search

ZNF646

0.41	Zinc finger protein 646

0.38	GO:2001141	regulation of RNA biosynthetic process
0.38	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.37	GO:0010468	regulation of gene expression
0.37	GO:0097659	nucleic acid-templated transcription
0.36	GO:0010467	gene expression
0.36	GO:0034645	cellular macromolecule biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.38	GO:0005515	protein binding
0.37	GO:0046872	metal ion binding
0.32	GO:0003700	DNA binding transcription factor activity

0.38

GO:0005634

nucleus

sp|O15016|TRI66_HUMAN
Tripartite motif-containing protein 66
Search

TRIM66

0.95	LOW QUALITY PROTEIN: tripartite motif-containing protein 66

0.40	GO:0070562	regulation of vitamin D receptor signaling pathway
0.40	GO:0071391	cellular response to estrogen stimulus
0.40	GO:0045892	negative regulation of transcription, DNA-templated
0.39	GO:1901796	regulation of signal transduction by p53 class mediator
0.39	GO:0031647	regulation of protein stability
0.39	GO:0046777	protein autophosphorylation
0.38	GO:0055074	calcium ion homeostasis
0.38	GO:0008285	negative regulation of cell proliferation
0.38	GO:0042981	regulation of apoptotic process
0.38	GO:0016567	protein ubiquitination

0.60	GO:0008270	zinc ion binding
0.42	GO:0003682	chromatin binding
0.41	GO:0034056	estrogen response element binding
0.40	GO:0016922	ligand-dependent nuclear receptor binding
0.40	GO:0002039	p53 binding
0.40	GO:0070577	lysine-acetylated histone binding
0.39	GO:0003713	transcription coactivator activity
0.38	GO:0042803	protein homodimerization activity
0.38	GO:0061630	ubiquitin protein ligase activity
0.36	GO:0004672	protein kinase activity

0.63	GO:0016235	aggresome
0.54	GO:0005654	nucleoplasm
0.40	GO:0005726	perichromatin fibrils
0.40	GO:0010369	chromocenter
0.39	GO:0005719	nuclear euchromatin
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|O15018|PDZD2_HUMAN
PDZ domain-containing protein 2
Search

PDZD2

0.81	PDZ domain-containing protein 2

0.43	GO:0007155	cell adhesion
0.36	GO:0010469	regulation of receptor activity
0.36	GO:0006935	chemotaxis
0.35	GO:0035556	intracellular signal transduction

0.37

GO:0005125

cytokine activity

0.49	GO:0005737	cytoplasm
0.44	GO:0005911	cell-cell junction
0.42	GO:0005576	extracellular region
0.42	GO:0012505	endomembrane system
0.41	GO:0005634	nucleus
0.37	GO:0014069	postsynaptic density
0.37	GO:0045177	apical part of cell
0.36	GO:0043005	neuron projection

sp|O15020|SPTN2_HUMAN
Spectrin beta chain, non-erythrocytic 2
Search

SPTBN2

0.77	Spectrin beta chain

0.81	GO:0051693	actin filament capping
0.70	GO:0007010	cytoskeleton organization
0.59	GO:0021692	cerebellar Purkinje cell layer morphogenesis
0.57	GO:0035264	multicellular organism growth
0.57	GO:0007416	synapse assembly
0.56	GO:0030534	adult behavior
0.51	GO:0016192	vesicle-mediated transport
0.47	GO:0007184	SMAD protein import into nucleus
0.47	GO:0007182	common-partner SMAD protein phosphorylation
0.47	GO:1900042	positive regulation of interleukin-2 secretion

0.76	GO:0005200	structural constituent of cytoskeleton
0.73	GO:0005543	phospholipid binding
0.73	GO:0003779	actin binding
0.58	GO:0045296	cadherin binding
0.46	GO:0030506	ankyrin binding
0.42	GO:0051020	GTPase binding
0.36	GO:0032403	protein complex binding
0.35	GO:0005516	calmodulin binding
0.35	GO:0098772	molecular function regulator
0.32	GO:0003723	RNA binding

0.85	GO:0008091	spectrin
0.56	GO:0098590	plasma membrane region
0.55	GO:0097458	neuron part
0.55	GO:0044297	cell body
0.55	GO:0045177	apical part of cell
0.51	GO:0030054	cell junction
0.49	GO:0005829	cytosol
0.46	GO:0031430	M band
0.45	GO:0031256	leading edge membrane
0.45	GO:0032279	asymmetric synapse

sp|O15021|MAST4_HUMAN
Microtubule-associated serine/threonine-protein kinase 4
Search

MAST4

0.94	Microtubule-associated serine/threonine-protein kinase 4

0.63	GO:0006468	protein phosphorylation
0.47	GO:0018209	peptidyl-serine modification
0.44	GO:0007010	cytoskeleton organization
0.41	GO:0035556	intracellular signal transduction

0.69	GO:0004674	protein serine/threonine kinase activity
0.63	GO:0000287	magnesium ion binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding

0.35	GO:0005622	intracellular
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0004674

sp|O15027|SC16A_HUMAN
Protein transport protein Sec16A
Search

SEC16A

0.65	SEC16 homolog A, endoplasmic reticulum export factor

0.84	GO:0048208	COPII vesicle coating
0.64	GO:0015031	protein transport
0.42	GO:0007029	endoplasmic reticulum organization
0.37	GO:0021762	substantia nigra development
0.34	GO:0046856	phosphatidylinositol dephosphorylation

0.32

GO:0016787

hydrolase activity

0.73	GO:0000139	Golgi membrane
0.69	GO:0005783	endoplasmic reticulum
0.39	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016787

sp|O15031|PLXB2_HUMAN
Plexin-B2
Search

0.86	Putative plexins functional semaphorin receptor

0.83	GO:0071526	semaphorin-plexin signaling pathway
0.57	GO:0050772	positive regulation of axonogenesis
0.56	GO:2001222	regulation of neuron migration
0.56	GO:0007405	neuroblast proliferation
0.55	GO:0001843	neural tube closure
0.52	GO:0007420	brain development
0.52	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.52	GO:0043087	regulation of GTPase activity
0.50	GO:0001932	regulation of protein phosphorylation
0.49	GO:0008360	regulation of cell shape

0.84	GO:0017154	semaphorin receptor activity
0.35	GO:0005515	protein binding
0.33	GO:0004707	MAP kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.31	GO:0016787	hydrolase activity

0.47	GO:0005887	integral component of plasma membrane
0.38	GO:0070062	extracellular exosome
0.37	GO:0009986	cell surface
0.33	GO:0000922	spindle pole
0.33	GO:0005815	microtubule organizing center
0.32	GO:0005634	nucleus

0.33	EC:2.7.11.24	GO:0004707
0.33	KEGG:R00162	GO:0004707

sp|O15033|AREL1_HUMAN
Apoptosis-resistant E3 ubiquitin protein ligase 1
Search

AREL1

0.97	Apoptosis-resistant E3 ubiquitin protein ligase 1

0.72	GO:0016567	protein ubiquitination
0.53	GO:0043066	negative regulation of apoptotic process
0.51	GO:0006511	ubiquitin-dependent protein catabolic process
0.36	GO:0006915	apoptotic process

0.73	GO:0004842	ubiquitin-protein transferase activity
0.50	GO:0016874	ligase activity
0.45	GO:0061659	ubiquitin-like protein ligase activity

0.47	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.50	EC:6	GO:0016874
0.73	KEGG:R03876	GO:0004842

sp|O15034|RIMB2_HUMAN
RIMS-binding protein 2
Search

RIMBP2

0.85	RIMS-binding protein 2

0.82

GO:0010923

negative regulation of phosphatase activity

0.37

GO:0005515

protein binding

0.49	GO:0045202	synapse
0.49	GO:0030054	cell junction
0.41	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

sp|O15037|KHNYN_HUMAN
Protein KHNYN
Search

KHNYN

0.97	KH and NYN domain containing

0.37

GO:0015074

DNA integration

0.59

GO:0003723

RNA binding

sp|O15040|TCPR2_HUMAN
Tectonin beta-propeller repeat-containing protein 2
Search

TECPR2

0.97	Tectonin beta-propeller repeat-containing protein 2

0.54

GO:0006914

autophagy

0.47

GO:0005515

protein binding

0.30

GO:0031224

intrinsic component of membrane

sp|O15041|SEM3E_HUMAN
Semaphorin-3E
Search

SEMA3E

0.97	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

0.76	GO:0002040	sprouting angiogenesis
0.73	GO:0071526	semaphorin-plexin signaling pathway
0.73	GO:0061138	morphogenesis of a branching epithelium
0.71	GO:0001953	negative regulation of cell-matrix adhesion
0.70	GO:2000249	regulation of actin cytoskeleton reorganization
0.69	GO:0035295	tube development
0.68	GO:0050919	negative chemotaxis
0.68	GO:2000026	regulation of multicellular organismal development
0.66	GO:0050808	synapse organization
0.66	GO:0051093	negative regulation of developmental process

0.79	GO:0030215	semaphorin receptor binding
0.69	GO:0038191	neuropilin binding
0.38	GO:0045499	chemorepellent activity

0.69	GO:0005615	extracellular space
0.37	GO:1903561	extracellular vesicle
0.30	GO:0016020	membrane

sp|O15042|SR140_HUMAN
U2 snRNP-associated SURP motif-containing protein
Search

U2SURP

0.91	U2 snRNP associated SURP domain containing

0.61	GO:0006396	RNA processing
0.34	GO:0016071	mRNA metabolic process

0.58	GO:0003723	RNA binding
0.34	GO:0008146	sulfotransferase activity
0.33	GO:0005515	protein binding

0.50	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0008146

sp|O15047|SET1A_HUMAN
Histone-lysine N-methyltransferase SETD1A
Search

SETD1A

0.90	Histone-lysine N-methyltransferase SETD1A

0.83	GO:0051568	histone H3-K4 methylation
0.71	GO:1902036	regulation of hematopoietic stem cell differentiation
0.65	GO:1902275	regulation of chromatin organization
0.46	GO:2000648	positive regulation of stem cell proliferation
0.46	GO:2000179	positive regulation of neural precursor cell proliferation
0.45	GO:0045637	regulation of myeloid cell differentiation
0.45	GO:0019827	stem cell population maintenance
0.42	GO:0032844	regulation of homeostatic process
0.40	GO:0010628	positive regulation of gene expression
0.38	GO:0040029	regulation of gene expression, epigenetic

0.83	GO:0042800	histone methyltransferase activity (H3-K4 specific)
0.66	GO:0008013	beta-catenin binding
0.59	GO:0008134	transcription factor binding
0.56	GO:0003723	RNA binding
0.46	GO:1990188	euchromatin binding
0.32	GO:0008270	zinc ion binding
0.32	GO:0003677	DNA binding

0.81	GO:0048188	Set1C/COMPASS complex
0.64	GO:0016607	nuclear speck
0.61	GO:0000790	nuclear chromatin
0.43	GO:0000791	euchromatin
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O15049|N4BP3_HUMAN
NEDD4-binding protein 3
Search

N4BP3

0.97	NEDD4-binding protein 3-B

0.46	GO:0007399	nervous system development
0.44	GO:0044772	mitotic cell cycle phase transition
0.38	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.37	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.35	GO:0051301	cell division
0.35	GO:0051255	spindle midzone assembly
0.34	GO:0051013	microtubule severing
0.34	GO:0030178	negative regulation of Wnt signaling pathway
0.34	GO:0016055	Wnt signaling pathway
0.34	GO:0051168	nuclear export

0.43	GO:0005515	protein binding
0.38	GO:0003774	motor activity
0.37	GO:0004842	ubiquitin-protein transferase activity

0.65	GO:0014069	postsynaptic density
0.58	GO:0031410	cytoplasmic vesicle
0.49	GO:0030425	dendrite
0.48	GO:0030424	axon
0.39	GO:0034657	GID complex
0.38	GO:0016459	myosin complex
0.35	GO:0005634	nucleus
0.35	GO:0005923	bicellular tight junction
0.34	GO:0030496	midbody
0.34	GO:0005813	centrosome

0.37

GO:0004842

sp|O15050|TRNK1_HUMAN
TPR and ankyrin repeat-containing protein 1
Search

TRANK1

0.96	Tetratricopeptide repeat and ankyrin repeat containing 1

0.34	GO:0006468	protein phosphorylation
0.32	GO:0007166	cell surface receptor signaling pathway
0.32	GO:0007186	G-protein coupled receptor signaling pathway

0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0004672	protein kinase activity
0.32	GO:0004930	G-protein coupled receptor activity

0.30

GO:0044425

membrane part

sp|O15054|KDM6B_HUMAN
Lysine-specific demethylase 6B
Search

KDM6B

0.97	Lysine-specific demethylase 6B

0.85	GO:0071557	histone H3-K27 demethylation
0.67	GO:0048333	mesodermal cell differentiation
0.66	GO:0045446	endothelial cell differentiation
0.66	GO:0055007	cardiac muscle cell differentiation
0.66	GO:0070301	cellular response to hydrogen peroxide
0.63	GO:0045165	cell fate commitment
0.61	GO:0006338	chromatin remodeling
0.59	GO:0045944	positive regulation of transcription by RNA polymerase II
0.52	GO:0032259	methylation
0.44	GO:0006954	inflammatory response

0.85	GO:0071558	histone demethylase activity (H3-K27 specific)
0.64	GO:0008013	beta-catenin binding
0.54	GO:0046872	metal ion binding
0.52	GO:0043565	sequence-specific DNA binding
0.52	GO:0008168	methyltransferase activity
0.41	GO:0003682	chromatin binding
0.40	GO:0051213	dioxygenase activity

0.59	GO:0005634	nucleus
0.37	GO:0031974	membrane-enclosed lumen
0.35	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.52

GO:0008168

sp|O15055|PER2_HUMAN
Period circadian protein homolog 2
Search

PER2

0.97	Period circadian protein like protein 2

0.59	GO:0007623	circadian rhythm
0.57	GO:0051946	regulation of glutamate uptake involved in transmission of nerve impulse
0.57	GO:0042752	regulation of circadian rhythm
0.55	GO:0070345	negative regulation of fat cell proliferation
0.54	GO:0050872	white fat cell differentiation
0.54	GO:0019249	lactate biosynthetic process
0.53	GO:0002931	response to ischemia
0.53	GO:2000026	regulation of multicellular organismal development
0.53	GO:2000678	negative regulation of transcription regulatory region DNA binding
0.52	GO:0031397	negative regulation of protein ubiquitination

0.50	GO:0000989	transcription factor activity, transcription factor binding
0.48	GO:0000976	transcription regulatory region sequence-specific DNA binding
0.47	GO:1990226	histone methyltransferase binding
0.47	GO:0001222	transcription corepressor binding
0.46	GO:0003682	chromatin binding
0.45	GO:0042826	histone deacetylase binding
0.45	GO:0036002	pre-mRNA binding
0.45	GO:0035257	nuclear hormone receptor binding
0.44	GO:0001047	core promoter binding
0.43	GO:0019900	kinase binding

0.60	GO:0005634	nucleus
0.49	GO:0048471	perinuclear region of cytoplasm
0.41	GO:0031974	membrane-enclosed lumen
0.38	GO:0044446	intracellular organelle part
0.38	GO:0005829	cytosol
0.37	GO:0043232	intracellular non-membrane-bounded organelle

sp|O15056|SYNJ2_HUMAN
Synaptojanin-2
Search

SYNJ2

0.97	LOW QUALITY PROTEIN: synaptojanin-2

0.81	GO:0046856	phosphatidylinositol dephosphorylation
0.52	GO:0048488	synaptic vesicle endocytosis
0.37	GO:0051640	organelle localization
0.37	GO:0046855	inositol phosphate dephosphorylation
0.37	GO:0007399	nervous system development
0.37	GO:0060322	head development
0.37	GO:0048513	animal organ development
0.37	GO:0098884	postsynaptic neurotransmitter receptor internalization
0.37	GO:1904980	positive regulation of endosome organization
0.36	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process

0.85	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity
0.58	GO:0003723	RNA binding
0.41	GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity
0.40	GO:0052744	phosphatidylinositol monophosphate phosphatase activity
0.39	GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity
0.37	GO:0017124	SH3 domain binding
0.36	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
0.36	GO:0004445	inositol-polyphosphate 5-phosphatase activity
0.36	GO:0030165	PDZ domain binding
0.35	GO:0008022	protein C-terminus binding

0.48	GO:0045202	synapse
0.39	GO:0098589	membrane region
0.39	GO:0043005	neuron projection
0.37	GO:0005856	cytoskeleton
0.37	GO:0098590	plasma membrane region
0.37	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0099512	supramolecular fiber
0.36	GO:0120038	plasma membrane bounded cell projection part
0.36	GO:0031315	extrinsic component of mitochondrial outer membrane
0.36	GO:0030118	clathrin coat

0.36

GO:0052629

sp|O15060|ZBT39_HUMAN
Zinc finger and BTB domain-containing protein 39
Search

ZBTB39

0.97	Zinc finger and BTB domain-containing protein 39

0.36	GO:1903506	regulation of nucleic acid-templated transcription
0.36	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0010468	regulation of gene expression
0.34	GO:0006351	transcription, DNA-templated
0.32	GO:0051052	regulation of DNA metabolic process
0.32	GO:1902679	negative regulation of RNA biosynthetic process
0.32	GO:0009584	detection of visible light
0.32	GO:0051716	cellular response to stimulus
0.32	GO:0006950	response to stress
0.31	GO:0023052	signaling

0.51	GO:0003676	nucleic acid binding
0.35	GO:0046872	metal ion binding
0.32	GO:0008020	G-protein coupled photoreceptor activity
0.32	GO:0042803	protein homodimerization activity
0.32	GO:0003700	DNA binding transcription factor activity
0.31	GO:1901265	nucleoside phosphate binding
0.31	GO:0036094	small molecule binding

0.35	GO:0005634	nucleus
0.32	GO:0001750	photoreceptor outer segment
0.32	GO:0043233	organelle lumen
0.31	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

sp|O15061|SYNEM_HUMAN
Synemin
Search

SYNM

0.94	Synemin isoform A

0.85	GO:0045104	intermediate filament cytoskeleton organization
0.69	GO:0031443	fast-twitch skeletal muscle fiber contraction

0.85	GO:0008307	structural constituent of muscle
0.77	GO:0005200	structural constituent of cytoskeleton
0.68	GO:0017166	vinculin binding
0.66	GO:0019215	intermediate filament binding
0.40	GO:0030674	protein binding, bridging

0.79	GO:0005882	intermediate filament
0.68	GO:0060053	neurofilament cytoskeleton
0.68	GO:0043034	costamere
0.63	GO:0042383	sarcolemma
0.62	GO:0005912	adherens junction
0.40	GO:0030018	Z disc

sp|O15062|ZBTB5_HUMAN
Zinc finger and BTB domain-containing protein 5
Search

ZBTB5

0.97	Zinc finger and BTB domain-containing protein 5

0.57	GO:0000122	negative regulation of transcription by RNA polymerase II
0.35	GO:0006351	transcription, DNA-templated

0.60	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.57	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.34	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.34	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.48	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.34

GO:0003899

sp|O15063|K0355_HUMAN
Uncharacterized protein KIAA0355
Search

0.36	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.34	GO:0006468	protein phosphorylation

0.36	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
0.33	GO:0030554	adenyl nucleotide binding
0.33	GO:0097367	carbohydrate derivative binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.30

GO:0031224

intrinsic component of membrane

0.36

GO:0004675

sp|O15066|KIF3B_HUMAN
Kinesin-like protein KIF3B
Search

sp|O15067|PUR4_HUMAN
Phosphoribosylformylglycinamidine synthase
Search

PFAS

0.50	Phosphoribosylformylglycinamidine synthase

0.70	GO:0006189	'de novo' IMP biosynthetic process
0.38	GO:0006541	glutamine metabolic process
0.38	GO:0042493	response to drug
0.32	GO:0006886	intracellular protein transport

0.76	GO:0004642	phosphoribosylformylglycinamidine synthase activity
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0046872	metal ion binding
0.34	GO:0016740	transferase activity
0.33	GO:0008536	Ran GTPase binding

0.38	GO:0070062	extracellular exosome
0.37	GO:0005737	cytoplasm
0.32	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.76	EC:6.3.5.3	GO:0004642
0.76	KEGG:R04463	GO:0004642

sp|O15068|MCF2L_HUMAN
Guanine nucleotide exchange factor DBS
Search

MCF2L

0.73	Guanine nucleotide exchange factor OSTIII

0.78	GO:0035023	regulation of Rho protein signal transduction
0.66	GO:0065009	regulation of molecular function
0.62	GO:0035556	intracellular signal transduction
0.43	GO:0046579	positive regulation of Ras protein signal transduction
0.38	GO:0045944	positive regulation of transcription by RNA polymerase II
0.37	GO:0043065	positive regulation of apoptotic process
0.36	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0006508	proteolysis

0.78	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.43	GO:0035091	phosphatidylinositol binding
0.34	GO:0005509	calcium ion binding
0.33	GO:0004252	serine-type endopeptidase activity

0.45	GO:0005622	intracellular
0.41	GO:0019897	extrinsic component of plasma membrane
0.41	GO:0009898	cytoplasmic side of plasma membrane
0.40	GO:0030027	lamellipodium
0.39	GO:0012505	endomembrane system
0.38	GO:0005615	extracellular space

0.33

GO:0004252

sp|O15069|NACAD_HUMAN
NAC-alpha domain-containing protein 1
Search

NACAD

0.79	NAC alpha domain containing

0.84

GO:0005854

nascent polypeptide-associated complex

sp|O15072|ATS3_HUMAN
A disintegrin and metalloproteinase with thrombospondin motifs 3
Search

ADAMTS3

0.96	A disintegrin and metalloproteinase with thrombospondin motifs 3

0.64	GO:0007229	integrin-mediated signaling pathway
0.61	GO:0006508	proteolysis
0.60	GO:0010573	vascular endothelial growth factor production
0.59	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway
0.59	GO:0032964	collagen biosynthetic process
0.50	GO:0051604	protein maturation
0.40	GO:0030199	collagen fibril organization
0.36	GO:0030574	collagen catabolic process
0.34	GO:0030324	lung development
0.34	GO:0043588	skin development

0.70	GO:0004222	metalloendopeptidase activity
0.54	GO:0046872	metal ion binding
0.35	GO:0008201	heparin binding
0.33	GO:0005515	protein binding

0.62	GO:0005576	extracellular region
0.35	GO:0031982	vesicle

0.70

GO:0004222

sp|O15075|DCLK1_HUMAN
Serine/threonine-protein kinase DCLK1
Search

DCLK1

0.90	Doublecortin like kinase 1

0.62	GO:0006468	protein phosphorylation
0.58	GO:0035556	intracellular signal transduction
0.53	GO:0018209	peptidyl-serine modification
0.53	GO:0021952	central nervous system projection neuron axonogenesis
0.52	GO:0048675	axon extension
0.52	GO:1900181	negative regulation of protein localization to nucleus
0.52	GO:0048813	dendrite morphogenesis
0.51	GO:0001764	neuron migration
0.50	GO:0030900	forebrain development
0.49	GO:0009615	response to virus

0.62	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005057	signal transducer activity, downstream of receptor
0.33	GO:0005516	calmodulin binding
0.33	GO:0005198	structural molecule activity

0.51	GO:0014069	postsynaptic density
0.43	GO:0005622	intracellular
0.34	GO:0030426	growth cone
0.34	GO:0030424	axon
0.34	GO:0005887	integral component of plasma membrane
0.33	GO:0099512	supramolecular fiber
0.32	GO:0043228	non-membrane-bounded organelle
0.32	GO:0044422	organelle part

sp|O15078|CE290_HUMAN
Centrosomal protein of 290 kDa
Search

CEP290

0.84	Centrosomal protein of isoform B

0.79	GO:0060271	cilium assembly
0.56	GO:0090316	positive regulation of intracellular protein transport
0.51	GO:0045893	positive regulation of transcription, DNA-templated
0.42	GO:0030916	otic vesicle formation
0.41	GO:0001654	eye development
0.41	GO:0048793	pronephros development
0.41	GO:0042461	photoreceptor cell development
0.40	GO:0030902	hindbrain development
0.39	GO:0045494	photoreceptor cell maintenance
0.39	GO:0030814	regulation of cAMP metabolic process

0.51	GO:0042802	identical protein binding
0.42	GO:0051011	microtubule minus-end binding

0.77	GO:0005813	centrosome
0.61	GO:0005634	nucleus
0.56	GO:0035869	ciliary transition zone
0.56	GO:0000930	gamma-tubulin complex
0.56	GO:0005814	centriole
0.49	GO:0005829	cytosol
0.41	GO:0097733	photoreceptor cell cilium
0.41	GO:0036064	ciliary basal body
0.38	GO:0035580	specific granule lumen
0.35	GO:0005576	extracellular region

sp|O15079|SNPH_HUMAN
Syntaphilin
Search

SNPH

0.94	Syntaphilin b

0.39	GO:0007399	nervous system development
0.39	GO:0060322	head development
0.38	GO:0048513	animal organ development
0.38	GO:0051650	establishment of vesicle localization
0.38	GO:0030154	cell differentiation
0.37	GO:0032253	dense core granule localization
0.37	GO:0060025	regulation of synaptic activity
0.37	GO:0019896	axonal transport of mitochondrion
0.37	GO:0051049	regulation of transport
0.36	GO:0008089	anterograde axonal transport

0.86	GO:0017075	syntaxin-1 binding
0.60	GO:0019894	kinesin binding
0.35	GO:0008017	microtubule binding

0.54	GO:0005881	cytoplasmic microtubule
0.44	GO:0043231	intracellular membrane-bounded organelle
0.43	GO:0031982	vesicle
0.40	GO:0042734	presynaptic membrane
0.40	GO:0043005	neuron projection
0.39	GO:0043025	neuronal cell body
0.38	GO:0030054	cell junction
0.37	GO:0097433	dense body
0.36	GO:0031090	organelle membrane
0.36	GO:0031967	organelle envelope

sp|O15083|ERC2_HUMAN
ERC protein 2
Search

ERC2

0.78	ERC protein 2

0.38

GO:0007416

synapse assembly

0.38	GO:0005515	protein binding
0.36	GO:0044877	macromolecular complex binding

0.83	GO:0048786	presynaptic active zone
0.44	GO:0042734	presynaptic membrane
0.43	GO:0030426	growth cone
0.41	GO:0030054	cell junction
0.39	GO:0005856	cytoskeleton
0.38	GO:0043195	terminal bouton
0.38	GO:0014069	postsynaptic density
0.37	GO:0043025	neuronal cell body
0.36	GO:0005783	endoplasmic reticulum
0.34	GO:0043234	protein complex

sp|O15084|ANR28_HUMAN
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
Search

ANKRD28

0.88	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

0.70

GO:0048208

COPII vesicle coating

0.54

GO:0005515

protein binding

0.70	GO:0005654	nucleoplasm
0.61	GO:0000139	Golgi membrane
0.58	GO:0005829	cytosol

sp|O15085|ARHGB_HUMAN
Rho guanine nucleotide exchange factor 11
Search

ARHGEF11

0.92	Rho guanine nucleotide exchange factor 11

0.84	GO:0007266	Rho protein signal transduction
0.77	GO:0035023	regulation of Rho protein signal transduction
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.66	GO:0065009	regulation of molecular function
0.51	GO:0045893	positive regulation of transcription, DNA-templated
0.45	GO:0043149	stress fiber assembly
0.45	GO:0048840	otolith development
0.45	GO:0003351	epithelial cilium movement
0.44	GO:0007368	determination of left/right symmetry
0.42	GO:0032956	regulation of actin cytoskeleton organization

0.78	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.70	GO:0001664	G-protein coupled receptor binding
0.45	GO:0001965	G-protein alpha-subunit binding
0.40	GO:0005096	GTPase activator activity
0.32	GO:0043565	sequence-specific DNA binding
0.32	GO:0003700	DNA binding transcription factor activity

0.47	GO:0005737	cytoplasm
0.32	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|O15090|ZN536_HUMAN
Zinc finger protein 536
Search

ZNF536

0.92	Zinc finger protein 536

0.62	GO:0048387	negative regulation of retinoic acid receptor signaling pathway
0.57	GO:0045665	negative regulation of neuron differentiation
0.55	GO:0000122	negative regulation of transcription by RNA polymerase II
0.44	GO:0006366	transcription by RNA polymerase II
0.40	GO:0007165	signal transduction

0.63	GO:0044323	retinoic acid-responsive element binding
0.58	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0046872	metal ion binding

0.40	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|O15091|MRRP3_HUMAN
Mitochondrial ribonuclease P protein 3
Search

KIAA0391

0.92	Mitochondrial ribonuclease P catalytic subunit

0.66	GO:0008033	tRNA processing
0.45	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.44	GO:0000963	mitochondrial RNA processing
0.40	GO:0034471	ncRNA 5'-end processing
0.33	GO:0006606	protein import into nucleus
0.32	GO:0006511	ubiquitin-dependent protein catabolic process
0.32	GO:0055085	transmembrane transport

0.49	GO:0004526	ribonuclease P activity
0.35	GO:0046872	metal ion binding
0.33	GO:0061608	nuclear import signal receptor activity
0.32	GO:0005215	transporter activity
0.32	GO:0003677	DNA binding
0.32	GO:0070003	threonine-type peptidase activity
0.32	GO:0004175	endopeptidase activity

0.61	GO:0005739	mitochondrion
0.53	GO:0009295	nucleoid
0.49	GO:0031974	membrane-enclosed lumen
0.45	GO:0044446	intracellular organelle part
0.45	GO:0043232	intracellular non-membrane-bounded organelle
0.43	GO:0030677	ribonuclease P complex
0.35	GO:0005634	nucleus
0.32	GO:0019773	proteasome core complex, alpha-subunit complex
0.30	GO:0031224	intrinsic component of membrane

0.49

EC:3.1.26.5

GO:0004526

sp|O15105|SMAD7_HUMAN
Mothers against decapentaplegic homolog 7
Search

SMAD7

0.65	Mothers against decapentaplegic homolog

0.76	GO:0007179	transforming growth factor beta receptor signaling pathway
0.60	GO:0010944	negative regulation of transcription by competitive promoter binding
0.60	GO:0034616	response to laminar fluid shear stress
0.59	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
0.59	GO:2000320	negative regulation of T-helper 17 cell differentiation
0.59	GO:0002725	negative regulation of T cell cytokine production
0.59	GO:0033137	negative regulation of peptidyl-serine phosphorylation
0.58	GO:0032925	regulation of activin receptor signaling pathway
0.58	GO:0051444	negative regulation of ubiquitin-protein transferase activity
0.58	GO:0060389	pathway-restricted SMAD protein phosphorylation

0.61	GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
0.60	GO:0048185	activin binding
0.60	GO:0070411	I-SMAD binding
0.59	GO:0034713	type I transforming growth factor beta receptor binding
0.57	GO:0003700	DNA binding transcription factor activity
0.56	GO:0008013	beta-catenin binding
0.55	GO:0005518	collagen binding
0.54	GO:0031625	ubiquitin protein ligase binding
0.53	GO:0044212	transcription regulatory region DNA binding
0.35	GO:0046872	metal ion binding

0.69	GO:0005667	transcription factor complex
0.58	GO:0016342	catenin complex
0.57	GO:0005634	nucleus
0.56	GO:0005913	cell-cell adherens junction
0.53	GO:0005813	centrosome
0.48	GO:0005829	cytosol
0.48	GO:0070013	intracellular organelle lumen
0.37	GO:0005768	endosome
0.30	GO:0016021	integral component of membrane

sp|O15111|IKKA_HUMAN
Inhibitor of nuclear factor kappa-B kinase subunit alpha
Search

CHUK

0.87	Conserved helix-loop-helix ubiquitous kinase

0.85	GO:0007252	I-kappaB phosphorylation
0.68	GO:1902741	positive regulation of interferon-alpha secretion
0.65	GO:0038061	NIK/NF-kappaB signaling
0.65	GO:0071356	cellular response to tumor necrosis factor
0.65	GO:0071276	cellular response to cadmium ion
0.64	GO:0032088	negative regulation of NF-kappaB transcription factor activity
0.64	GO:0098586	cellular response to virus
0.59	GO:0045944	positive regulation of transcription by RNA polymerase II
0.58	GO:0034614	cellular response to reactive oxygen species
0.51	GO:0051092	positive regulation of NF-kappaB transcription factor activity

0.86	GO:0008384	IkappaB kinase activity
0.65	GO:0097110	scaffold protein binding
0.58	GO:0042803	protein homodimerization activity
0.57	GO:0046982	protein heterodimerization activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0015485	cholesterol binding
0.37	GO:0031625	ubiquitin protein ligase binding

0.55	GO:0005829	cytosol
0.55	GO:0005654	nucleoplasm
0.49	GO:1902554	serine/threonine protein kinase complex
0.38	GO:0035631	CD40 receptor complex
0.36	GO:0009898	cytoplasmic side of plasma membrane
0.36	GO:0005789	endoplasmic reticulum membrane

0.86

EC:2.7.11.10

GO:0008384

sp|O15116|LSM1_HUMAN
U6 snRNA-associated Sm-like protein LSm1
Search

LSM1

0.93	LSM1 homolog, mRNA degradation associated

0.76	GO:0000956	nuclear-transcribed mRNA catabolic process
0.56	GO:0008334	histone mRNA metabolic process
0.54	GO:0019827	stem cell population maintenance
0.54	GO:0045665	negative regulation of neuron differentiation
0.36	GO:0008380	RNA splicing
0.36	GO:0006397	mRNA processing

0.47	GO:0000339	RNA cap binding
0.40	GO:0036002	pre-mRNA binding
0.38	GO:0003729	mRNA binding
0.34	GO:0005515	protein binding

0.58	GO:0030529	intracellular ribonucleoprotein complex
0.48	GO:0005845	mRNA cap binding complex
0.48	GO:1990726	Lsm1-7-Pat1 complex
0.44	GO:0043232	intracellular non-membrane-bounded organelle
0.44	GO:0005634	nucleus
0.42	GO:0044444	cytoplasmic part
0.41	GO:0019013	viral nucleocapsid
0.39	GO:0043025	neuronal cell body
0.39	GO:0030425	dendrite
0.39	GO:0030424	axon

sp|O15117|FYB_HUMAN
FYN-binding protein
Search

FYB1

0.92	FYN binding protein b

0.74	GO:0006955	immune response
0.59	GO:0072659	protein localization to plasma membrane
0.41	GO:0045576	mast cell activation
0.40	GO:0007165	signal transduction
0.40	GO:0006607	NLS-bearing protein import into nucleus
0.38	GO:0002253	activation of immune response
0.36	GO:0006468	protein phosphorylation

0.64	GO:0008289	lipid binding
0.44	GO:0005102	receptor binding
0.42	GO:0032403	protein complex binding

0.74	GO:0015629	actin cytoskeleton
0.44	GO:0005886	plasma membrane
0.39	GO:0030054	cell junction
0.38	GO:0005829	cytosol
0.37	GO:0005634	nucleus
0.33	GO:0046930	pore complex

sp|O15118|NPC1_HUMAN
Niemann-Pick C1 protein
Search

NPC1

0.96	NPC intracellular cholesterol transporter 1

0.74	GO:0006869	lipid transport
0.59	GO:2000189	positive regulation of cholesterol homeostasis
0.59	GO:0042632	cholesterol homeostasis
0.57	GO:0071404	cellular response to low-density lipoprotein particle stimulus
0.56	GO:0031579	membrane raft organization
0.56	GO:0007628	adult walking behavior
0.56	GO:0015850	organic hydroxy compound transport
0.56	GO:0016242	negative regulation of macroautophagy
0.52	GO:0006914	autophagy
0.52	GO:0071383	cellular response to steroid hormone stimulus

0.76	GO:0005319	lipid transporter activity
0.55	GO:0015485	cholesterol binding
0.37	GO:0019239	deaminase activity
0.36	GO:0104005	hijacked molecular function
0.34	GO:0005515	protein binding
0.34	GO:0004888	transmembrane signaling receptor activity

0.56	GO:0048471	perinuclear region of cytoplasm
0.54	GO:0005635	nuclear envelope
0.53	GO:0005764	lysosome
0.53	GO:0045121	membrane raft
0.51	GO:0005783	endoplasmic reticulum
0.51	GO:0005768	endosome
0.49	GO:0005887	integral component of plasma membrane
0.49	GO:0005794	Golgi apparatus
0.47	GO:0005576	extracellular region
0.40	GO:0098852	lytic vacuole membrane

sp|O15119|TBX3_HUMAN
T-box transcription factor TBX3
Search

TBX3

0.91

T-box 3

0.79	GO:0046884	follicle-stimulating hormone secretion
0.77	GO:0032275	luteinizing hormone secretion
0.77	GO:0003167	atrioventricular bundle cell differentiation
0.76	GO:0060931	sinoatrial node cell development
0.75	GO:0010159	specification of animal organ position
0.74	GO:0060596	mammary placode formation
0.74	GO:0030540	female genitalia development
0.74	GO:0060923	cardiac muscle cell fate commitment
0.74	GO:0045662	negative regulation of myoblast differentiation
0.74	GO:0090398	cellular senescence

0.70	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.69	GO:0001102	RNA polymerase II activating transcription factor binding
0.68	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding

0.61

GO:0005634

nucleus

sp|O15120|PLCB_HUMAN
1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Search

AGPAT2

0.62	1-acylglycerol-3-phosphate O-acyltransferase 2

0.54	GO:0046474	glycerophospholipid biosynthetic process
0.53	GO:0046473	phosphatidic acid metabolic process
0.53	GO:0001819	positive regulation of cytokine production

0.63

GO:0016746

transferase activity, transferring acyl groups

0.48	GO:0005783	endoplasmic reticulum
0.30	GO:0031224	intrinsic component of membrane

0.63

GO:0016746

sp|O15121|DEGS1_HUMAN
Sphingolipid delta(4)-desaturase DES1
Search

DEGS1

0.94	Delta 4-desaturase, sphingolipid 1

0.83	GO:0030148	sphingolipid biosynthetic process
0.52	GO:0055114	oxidation-reduction process
0.50	GO:0006672	ceramide metabolic process
0.41	GO:0043604	amide biosynthetic process
0.40	GO:0006667	sphinganine metabolic process
0.39	GO:0006633	fatty acid biosynthetic process
0.36	GO:0043065	positive regulation of apoptotic process
0.35	GO:0043312	neutrophil degranulation
0.35	GO:0033559	unsaturated fatty acid metabolic process
0.33	GO:0007186	G-protein coupled receptor signaling pathway

0.85	GO:0042284	sphingolipid delta-4 desaturase activity
0.41	GO:0000170	sphingosine hydroxylase activity
0.34	GO:0016503	pheromone receptor activity
0.33	GO:0004497	monooxygenase activity
0.33	GO:0009055	electron transfer activity

0.44	GO:0005739	mitochondrion
0.39	GO:0005789	endoplasmic reticulum membrane
0.35	GO:0035579	specific granule membrane
0.33	GO:0005887	integral component of plasma membrane

sp|O15123|ANGP2_HUMAN
Angiopoietin-2
Search

ANGPT2

0.94	Angiopoietin-2

0.70	GO:0048014	Tie signaling pathway
0.64	GO:0001525	angiogenesis
0.62	GO:0050928	negative regulation of positive chemotaxis
0.61	GO:0043535	regulation of blood vessel endothelial cell migration
0.59	GO:0007162	negative regulation of cell adhesion
0.58	GO:0010596	negative regulation of endothelial cell migration
0.56	GO:0016525	negative regulation of angiogenesis
0.55	GO:0010810	regulation of cell-substrate adhesion
0.50	GO:0072012	glomerulus vasculature development
0.49	GO:2000446	regulation of macrophage migration inhibitory factor signaling pathway

0.85	GO:0030971	receptor tyrosine kinase binding
0.35	GO:0005172	vascular endothelial growth factor receptor binding
0.35	GO:0046872	metal ion binding
0.34	GO:0005088	Ras guanyl-nucleotide exchange factor activity

0.54	GO:0005615	extracellular space
0.46	GO:0005902	microvillus
0.45	GO:0098857	membrane microdomain
0.39	GO:0005886	plasma membrane
0.36	GO:0005634	nucleus
0.35	GO:1903561	extracellular vesicle

sp|O15126|SCAM1_HUMAN
Secretory carrier-associated membrane protein 1
Search

SCAMP1

0.67	Secretory carrier-associated membrane protein 1

0.65	GO:0015031	protein transport
0.50	GO:0006887	exocytosis
0.35	GO:0002283	neutrophil activation involved in immune response
0.35	GO:0002446	neutrophil mediated immunity
0.35	GO:0006892	post-Golgi vesicle-mediated transport
0.34	GO:0006897	endocytosis

0.35	GO:0005515	protein binding
0.32	GO:0003723	RNA binding

0.56	GO:0042589	zymogen granule membrane
0.55	GO:0055038	recycling endosome membrane
0.54	GO:0030672	synaptic vesicle membrane
0.52	GO:0005802	trans-Golgi network
0.36	GO:0030136	clathrin-coated vesicle
0.36	GO:0035579	specific granule membrane
0.35	GO:0043195	terminal bouton
0.33	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O15127|SCAM2_HUMAN
Secretory carrier-associated membrane protein 2
Search

SCAMP2

0.68	Secretory carrier-associated membrane protein 2

0.65	GO:0015031	protein transport
0.36	GO:0016192	vesicle-mediated transport
0.35	GO:0098657	import into cell
0.35	GO:0046907	intracellular transport
0.35	GO:0034613	cellular protein localization

0.36	GO:0005515	protein binding
0.35	GO:0008565	protein transporter activity

0.58	GO:0032588	trans-Golgi network membrane
0.58	GO:0055038	recycling endosome membrane
0.40	GO:0030133	transport vesicle
0.38	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

sp|O15130|NPFF_HUMAN
Pro-FMRFamide-related neuropeptide FF
Search

NPFF

0.97	Neuropeptide FF-amide peptide precursor

0.76	GO:0010469	regulation of receptor activity
0.57	GO:0007218	neuropeptide signaling pathway
0.56	GO:0060079	excitatory postsynaptic potential
0.54	GO:0070253	somatostatin secretion
0.52	GO:0030103	vasopressin secretion
0.51	GO:0002438	acute inflammatory response to antigenic stimulus
0.51	GO:0010459	negative regulation of heart rate
0.50	GO:0043278	response to morphine
0.50	GO:0051930	regulation of sensory perception of pain
0.50	GO:0032099	negative regulation of appetite

0.85	GO:0005184	neuropeptide hormone activity
0.57	GO:0001664	G-protein coupled receptor binding

0.60	GO:0043204	perikaryon
0.59	GO:0043679	axon terminus
0.57	GO:0030425	dendrite
0.55	GO:0098794	postsynapse
0.53	GO:0005615	extracellular space
0.44	GO:0031982	vesicle

sp|O15131|IMA6_HUMAN
Importin subunit alpha-6
Search

KPNA5

0.60	Importin subunit alpha

0.80	GO:0006606	protein import into nucleus
0.49	GO:0060135	maternal process involved in female pregnancy
0.46	GO:0045944	positive regulation of transcription by RNA polymerase II
0.34	GO:0075733	intracellular transport of virus
0.33	GO:0044068	modulation by symbiont of host cellular process
0.33	GO:0019048	modulation by virus of host morphology or physiology

0.83	GO:0061608	nuclear import signal receptor activity
0.70	GO:0008565	protein transporter activity
0.51	GO:0008139	nuclear localization sequence binding
0.35	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.49	GO:0005829	cytosol
0.44	GO:0012505	endomembrane system
0.44	GO:0043233	organelle lumen
0.42	GO:0031967	organelle envelope
0.41	GO:0043234	protein complex
0.33	GO:0044217	other organism part
0.33	GO:0018995	host
0.30	GO:0031224	intrinsic component of membrane

sp|O15143|ARC1B_HUMAN
Actin-related protein 2/3 complex subunit 1B
Search

ARPC1B

0.75	Actin-related protein 2/3 complex subunit

0.80	GO:0034314	Arp2/3 complex-mediated actin nucleation
0.40	GO:0032355	response to estradiol
0.40	GO:0043627	response to estrogen
0.37	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.36	GO:0048013	ephrin receptor signaling pathway
0.33	GO:0061024	membrane organization

0.69	GO:0003779	actin binding
0.53	GO:0032403	protein complex binding
0.51	GO:0005200	structural constituent of cytoskeleton

0.79	GO:0005885	Arp2/3 protein complex
0.47	GO:0005737	cytoplasm
0.45	GO:0036195	muscle cell projection membrane
0.42	GO:0036284	tubulobulbar complex
0.37	GO:0070062	extracellular exosome
0.36	GO:0005925	focal adhesion

sp|O15144|ARPC2_HUMAN
Actin-related protein 2/3 complex subunit 2
Search

ARPC2

0.67	Actin-related protein 2/3 complex subunit 2

0.84	GO:0030041	actin filament polymerization
0.81	GO:0034314	Arp2/3 complex-mediated actin nucleation
0.53	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
0.52	GO:0010592	positive regulation of lamellipodium assembly
0.36	GO:1905926	positive regulation of invadopodium assembly
0.36	GO:2000814	positive regulation of barbed-end actin filament capping
0.36	GO:0034021	response to silicon dioxide
0.36	GO:0072752	cellular response to rapamycin
0.35	GO:0070358	actin polymerization-dependent cell motility
0.35	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis

0.73	GO:0003779	actin binding
0.51	GO:0005200	structural constituent of cytoskeleton
0.50	GO:0032403	protein complex binding
0.35	GO:0035254	glutamate receptor binding
0.35	GO:0051117	ATPase binding
0.35	GO:0019894	kinesin binding
0.34	GO:0004930	G-protein coupled receptor activity

0.80	GO:0005885	Arp2/3 protein complex
0.55	GO:0036195	muscle cell projection membrane
0.51	GO:0005925	focal adhesion
0.50	GO:0031252	cell leading edge
0.49	GO:0005737	cytoplasm
0.47	GO:0031982	vesicle
0.45	GO:0012505	endomembrane system
0.39	GO:0043005	neuron projection
0.38	GO:0045202	synapse
0.37	GO:0043230	extracellular organelle

sp|O15145|ARPC3_HUMAN
Actin-related protein 2/3 complex subunit 3
Search

ARPC3

0.73	Actin-related protein 2/3 complex subunit 3

0.80	GO:0034314	Arp2/3 complex-mediated actin nucleation
0.39	GO:1990090	cellular response to nerve growth factor stimulus
0.36	GO:0070358	actin polymerization-dependent cell motility
0.35	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.35	GO:0048013	ephrin receptor signaling pathway
0.33	GO:0061024	membrane organization

0.68	GO:0003779	actin binding
0.48	GO:0005200	structural constituent of cytoskeleton
0.48	GO:0032403	protein complex binding

0.79	GO:0005885	Arp2/3 protein complex
0.52	GO:0030027	lamellipodium
0.46	GO:0005737	cytoplasm
0.40	GO:0061850	growth cone leading edge
0.38	GO:0031941	filamentous actin
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

sp|O15146|MUSK_HUMAN
Muscle, skeletal receptor tyrosine-protein kinase
Search

MUSK

0.57	Muscle associated receptor tyrosine kinase

0.76	GO:0018108	peptidyl-tyrosine phosphorylation
0.57	GO:0007528	neuromuscular junction development
0.52	GO:0001934	positive regulation of protein phosphorylation
0.44	GO:2000539	regulation of protein geranylgeranylation
0.43	GO:0001941	postsynaptic membrane organization
0.43	GO:0043113	receptor clustering
0.42	GO:0008582	regulation of synaptic growth at neuromuscular junction
0.41	GO:1904395	positive regulation of skeletal muscle acetylcholine-gated channel clustering
0.40	GO:0043525	positive regulation of neuron apoptotic process
0.40	GO:0030154	cell differentiation

0.76	GO:0004713	protein tyrosine kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0019199	transmembrane receptor protein kinase activity
0.39	GO:0030165	PDZ domain binding
0.36	GO:0019901	protein kinase binding
0.35	GO:0046872	metal ion binding
0.35	GO:0042802	identical protein binding
0.33	GO:0051082	unfolded protein binding

0.53	GO:0043235	receptor complex
0.41	GO:0045211	postsynaptic membrane
0.41	GO:0031594	neuromuscular junction
0.39	GO:0030054	cell junction
0.38	GO:0005887	integral component of plasma membrane
0.36	GO:0009897	external side of plasma membrane
0.35	GO:0042995	cell projection
0.33	GO:0005783	endoplasmic reticulum

0.76

EC:2.7.10

GO:0004713

sp|O15151|MDM4_HUMAN
Protein Mdm4
Search

sp|O15155|BET1_HUMAN
BET1 homolog
Search

BET1

0.96	Putative blocked early in transport 1 log

0.40	GO:0048280	vesicle fusion with Golgi apparatus
0.39	GO:0006888	ER to Golgi vesicle-mediated transport
0.36	GO:0015031	protein transport
0.36	GO:0006901	vesicle coating
0.35	GO:0048199	vesicle targeting, to, from or within Golgi
0.35	GO:0048194	Golgi vesicle budding
0.34	GO:0006461	protein complex assembly
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.32	GO:0008033	tRNA processing

0.40	GO:0019905	syntaxin binding
0.33	GO:0004930	G-protein coupled receptor activity
0.33	GO:0003924	GTPase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0016740	transferase activity

0.51	GO:0000139	Golgi membrane
0.40	GO:0031201	SNARE complex
0.40	GO:0005801	cis-Golgi network
0.40	GO:0031985	Golgi cisterna
0.37	GO:0005789	endoplasmic reticulum membrane
0.36	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
0.35	GO:0030133	transport vesicle
0.30	GO:0016021	integral component of membrane

0.32

EC:2

GO:0016740

sp|O15156|ZBT7B_HUMAN
Zinc finger and BTB domain-containing protein 7B
Search

ZBTB7B

0.92	Zinc finger and BTB domain-containing protein 7B

0.64	GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation
0.63	GO:2000320	negative regulation of T-helper 17 cell differentiation
0.56	GO:0045944	positive regulation of transcription by RNA polymerase II
0.54	GO:0006366	transcription by RNA polymerase II
0.50	GO:0010629	negative regulation of gene expression
0.45	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding
0.45	GO:0045600	positive regulation of fat cell differentiation
0.43	GO:0008285	negative regulation of cell proliferation
0.38	GO:0007275	multicellular organism development
0.37	GO:0007398	ectoderm development

0.57	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.57	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.54	GO:0042803	protein homodimerization activity
0.35	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.35	GO:0046872	metal ion binding
0.34	GO:0030552	cAMP binding
0.33	GO:0005249	voltage-gated potassium channel activity
0.30	GO:0003824	catalytic activity

0.51	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.35

GO:0016538

sp|O15160|RPAC1_HUMAN
DNA-directed RNA polymerases I and III subunit RPAC1
Search

POLR1C

0.90	RNA polymerase I subunit C

0.58	GO:0006351	transcription, DNA-templated
0.45	GO:0048703	embryonic viscerocranium morphogenesis
0.44	GO:0051216	cartilage development
0.40	GO:0042254	ribosome biogenesis
0.36	GO:0040029	regulation of gene expression, epigenetic
0.35	GO:0032481	positive regulation of type I interferon production
0.34	GO:0016458	gene silencing
0.34	GO:0010628	positive regulation of gene expression
0.34	GO:0006325	chromatin organization
0.34	GO:0045892	negative regulation of transcription, DNA-templated

0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.68	GO:0046983	protein dimerization activity
0.53	GO:0003677	DNA binding

0.58	GO:0005736	DNA-directed RNA polymerase I complex
0.57	GO:0005666	DNA-directed RNA polymerase III complex
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.70

GO:0003899

sp|O15162|PLS1_HUMAN
Phospholipid scramblase 1
Search

PLSCR1

0.68	Phospholipid scramblase

0.81	GO:0017121	phospholipid scrambling
0.71	GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
0.68	GO:0045071	negative regulation of viral genome replication
0.66	GO:0035456	response to interferon-beta
0.64	GO:0045089	positive regulation of innate immune response
0.62	GO:0006915	apoptotic process
0.62	GO:0051607	defense response to virus
0.59	GO:0006366	transcription by RNA polymerase II
0.59	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway
0.59	GO:0045944	positive regulation of transcription by RNA polymerase II

0.83	GO:0017128	phospholipid scramblase activity
0.67	GO:0005154	epidermal growth factor receptor binding
0.64	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.63	GO:0017124	SH3 domain binding
0.61	GO:0042609	CD4 receptor binding
0.56	GO:0005509	calcium ion binding
0.55	GO:0019899	enzyme binding
0.38	GO:0003677	DNA binding

0.63	GO:0045121	membrane raft
0.59	GO:0031012	extracellular matrix
0.58	GO:0005730	nucleolus
0.58	GO:0005794	Golgi apparatus
0.56	GO:0005829	cytosol
0.54	GO:0005887	integral component of plasma membrane
0.43	GO:0070062	extracellular exosome

sp|O15164|TIF1A_HUMAN
Transcription intermediary factor 1-alpha
Search

TRIM24

0.87	Tripartite motif containing 24

0.72	GO:0070562	regulation of vitamin D receptor signaling pathway
0.72	GO:0071391	cellular response to estrogen stimulus
0.68	GO:1901796	regulation of signal transduction by p53 class mediator
0.65	GO:0031647	regulation of protein stability
0.64	GO:0046777	protein autophosphorylation
0.64	GO:0016567	protein ubiquitination
0.64	GO:0055074	calcium ion homeostasis
0.63	GO:0008285	negative regulation of cell proliferation
0.62	GO:0042981	regulation of apoptotic process
0.59	GO:0045893	positive regulation of transcription, DNA-templated

0.75	GO:0034056	estrogen response element binding
0.70	GO:0016922	ligand-dependent nuclear receptor binding
0.70	GO:0002039	p53 binding
0.69	GO:0070577	lysine-acetylated histone binding
0.65	GO:0003713	transcription coactivator activity
0.64	GO:0003682	chromatin binding
0.63	GO:0008270	zinc ion binding
0.61	GO:0061630	ubiquitin protein ligase activity
0.53	GO:0004672	protein kinase activity
0.52	GO:0070410	co-SMAD binding

0.72	GO:0005726	perichromatin fibrils
0.67	GO:0005719	nuclear euchromatin
0.59	GO:0005654	nucleoplasm
0.43	GO:0005737	cytoplasm

sp|O15165|LRAD4_HUMAN
Low-density lipoprotein receptor class A domain-containing protein 4
Search

LDLRAD4

0.97	Low-density lipoprotein receptor class A domain-containing protein 4

0.67	GO:0010991	negative regulation of SMAD protein complex assembly
0.66	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
0.65	GO:0010719	negative regulation of epithelial to mesenchymal transition
0.63	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.61	GO:0030336	negative regulation of cell migration

0.65

GO:0070412

R-SMAD binding

0.53	GO:0005654	nucleoplasm
0.43	GO:0031901	early endosome membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O15169|AXIN1_HUMAN
Axin-1
Search

0.74	GO:0016055	Wnt signaling pathway
0.56	GO:0090090	negative regulation of canonical Wnt signaling pathway
0.55	GO:0032147	activation of protein kinase activity
0.55	GO:0051443	positive regulation of ubiquitin-protein transferase activity
0.53	GO:0045732	positive regulation of protein catabolic process
0.50	GO:0045893	positive regulation of transcription, DNA-templated
0.49	GO:0043623	cellular protein complex assembly
0.49	GO:0048320	axial mesoderm formation
0.49	GO:0030910	olfactory placode formation
0.48	GO:0001743	optic placode formation

0.85	GO:0030159	receptor signaling complex scaffold activity
0.58	GO:0070411	I-SMAD binding
0.55	GO:0008013	beta-catenin binding
0.53	GO:0031625	ubiquitin protein ligase binding
0.51	GO:0042802	identical protein binding
0.46	GO:0004871	signal transducer activity
0.43	GO:0005096	GTPase activator activity
0.37	GO:0046983	protein dimerization activity
0.37	GO:0019901	protein kinase binding
0.37	GO:0019904	protein domain specific binding

0.86	GO:0030877	beta-catenin destruction complex
0.56	GO:0016328	lateral plasma membrane
0.53	GO:0048471	perinuclear region of cytoplasm
0.45	GO:0005634	nucleus
0.37	GO:0031410	cytoplasmic vesicle
0.36	GO:1990909	Wnt signalosome
0.36	GO:0005829	cytosol
0.35	GO:0005881	cytoplasmic microtubule
0.35	GO:0005938	cell cortex

sp|O15172|PSPHL_HUMAN
Putative phosphoserine phosphatase-like protein
Search

0.10	Putative phosphoserine phosphatase-like protein

0.75	GO:0006564	L-serine biosynthetic process
0.67	GO:0016311	dephosphorylation
0.41	GO:0033574	response to testosterone
0.40	GO:0009612	response to mechanical stimulus
0.39	GO:0031667	response to nutrient levels
0.38	GO:0008283	cell proliferation

0.79	GO:0004647	phosphoserine phosphatase activity
0.50	GO:0042803	protein homodimerization activity
0.48	GO:0005509	calcium ion binding
0.46	GO:0000287	magnesium ion binding

0.39	GO:0043005	neuron projection
0.34	GO:0005829	cytosol

0.79

EC:3.1.3.3

GO:0004647

sp|O15173|PGRC2_HUMAN
Membrane-associated progesterone receptor component 2
Search

PGRMC2

0.90	Membrane-associated progesterone receptor component

0.42	GO:1903538	regulation of meiotic cell cycle process involved in oocyte maturation
0.37	GO:1903537	meiotic cell cycle process involved in oocyte maturation
0.35	GO:0043401	steroid hormone mediated signaling pathway
0.35	GO:0099563	modification of synaptic structure
0.34	GO:0043312	neutrophil degranulation
0.34	GO:1905809	negative regulation of synapse organization
0.34	GO:1903078	positive regulation of protein localization to plasma membrane
0.34	GO:0008306	associative learning
0.34	GO:0007613	memory
0.34	GO:0007411	axon guidance

0.44	GO:0020037	heme binding
0.43	GO:0005496	steroid binding
0.36	GO:0005515	protein binding
0.35	GO:0003707	steroid hormone receptor activity
0.34	GO:0032440	2-alkenal reductase [NAD(P)] activity

0.51	GO:0005635	nuclear envelope
0.40	GO:0030868	smooth endoplasmic reticulum membrane
0.37	GO:0070062	extracellular exosome
0.36	GO:0042585	germinal vesicle
0.36	GO:0106003	amyloid-beta complex
0.36	GO:1990385	meiotic spindle midzone
0.35	GO:0030496	midbody
0.35	GO:0043025	neuronal cell body
0.35	GO:0043005	neuron projection
0.35	GO:0000775	chromosome, centromeric region

0.34

EC:1.3.1.74

GO:0032440

sp|O15178|BRAC_HUMAN
Brachyury protein
Search

0.96	T-box transcription factor Brachyury

0.61	GO:0014028	notochord formation
0.61	GO:0003257	positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
0.60	GO:0036342	post-anal tail morphogenesis
0.59	GO:0007341	penetration of zona pellucida
0.59	GO:0007509	mesoderm migration involved in gastrulation
0.58	GO:0001839	neural plate morphogenesis
0.58	GO:0001756	somitogenesis
0.58	GO:0023019	signal transduction involved in regulation of gene expression
0.58	GO:0006351	transcription, DNA-templated
0.58	GO:0061371	determination of heart left/right asymmetry

0.61	GO:0003700	DNA binding transcription factor activity
0.61	GO:0001158	enhancer sequence-specific DNA binding
0.58	GO:0001102	RNA polymerase II activating transcription factor binding
0.57	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.56	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding
0.36	GO:0051087	chaperone binding

0.61	GO:0005634	nucleus
0.51	GO:0000785	chromatin
0.48	GO:0070013	intracellular organelle lumen
0.39	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|O15182|CETN3_HUMAN
Centrin-3
Search

CETN3

0.96	Centrin, EF-hand protein, 3

0.36	GO:0031023	microtubule organizing center organization
0.35	GO:0007049	cell cycle
0.35	GO:0007020	microtubule nucleation
0.35	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.34	GO:0043549	regulation of kinase activity
0.34	GO:0051301	cell division

0.70	GO:0005509	calcium ion binding
0.51	GO:0031683	G-protein beta/gamma-subunit complex binding
0.48	GO:0008017	microtubule binding
0.35	GO:0005200	structural constituent of cytoskeleton
0.34	GO:0042802	identical protein binding

0.53	GO:0032391	photoreceptor connecting cilium
0.52	GO:0005814	centriole
0.52	GO:0036064	ciliary basal body
0.51	GO:0005813	centrosome
0.36	GO:0005825	half bridge of spindle pole body
0.36	GO:0000111	nucleotide-excision repair factor 2 complex
0.35	GO:0070390	transcription export complex 2
0.35	GO:0005730	nucleolus

sp|O15194|CTDSL_HUMAN
CTD small phosphatase-like protein
Search

CTDSPL

0.95	CTD small phosphatase like

0.67	GO:0016311	dephosphorylation
0.52	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle
0.48	GO:0001933	negative regulation of protein phosphorylation
0.39	GO:0036211	protein modification process
0.38	GO:0044267	cellular protein metabolic process

0.68	GO:0016791	phosphatase activity
0.39	GO:0140096	catalytic activity, acting on a protein
0.34	GO:0005515	protein binding
0.34	GO:0046872	metal ion binding
0.34	GO:0044877	macromolecular complex binding

0.35	GO:0070062	extracellular exosome
0.35	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.68

EC:3.1.3 EC:3.1.3.41

GO:0016791

sp|O15195|VILL_HUMAN
Villin-like protein
Search

VILL

0.83	Villin like

0.65	GO:0007010	cytoskeleton organization
0.51	GO:0051014	actin filament severing
0.51	GO:0051693	actin filament capping
0.48	GO:0030838	positive regulation of actin filament polymerization
0.47	GO:0001951	intestinal D-glucose absorption
0.47	GO:0060327	cytoplasmic actin-based contraction involved in cell motility
0.46	GO:0032532	regulation of microvillus length
0.46	GO:2000394	positive regulation of lamellipodium morphogenesis
0.46	GO:0097435	supramolecular fiber organization
0.46	GO:0035729	cellular response to hepatocyte growth factor stimulus

0.78	GO:0051015	actin filament binding
0.50	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.47	GO:0035727	lysophosphatidic acid binding
0.45	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.45	GO:0005509	calcium ion binding
0.42	GO:0042803	protein homodimerization activity
0.35	GO:0005200	structural constituent of cytoskeleton
0.35	GO:0016791	phosphatase activity
0.31	GO:0140096	catalytic activity, acting on a protein

0.46	GO:0032433	filopodium tip
0.45	GO:0005902	microvillus
0.44	GO:0005903	brush border
0.44	GO:0032432	actin filament bundle
0.44	GO:0001726	ruffle
0.44	GO:0030027	lamellipodium
0.37	GO:0005886	plasma membrane
0.34	GO:0070062	extracellular exosome
0.32	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

0.35

EC:3.1.3 EC:3.1.3.41

GO:0016791

sp|O15197|EPHB6_HUMAN
Ephrin type-B receptor 6
Search

EPHB6

0.92	EPH receptor B6

0.83	GO:0048013	ephrin receptor signaling pathway
0.78	GO:0001806	type IV hypersensitivity
0.76	GO:2000523	regulation of T cell costimulation
0.75	GO:0050798	activated T cell proliferation
0.72	GO:0050663	cytokine secretion
0.70	GO:0032092	positive regulation of protein binding
0.64	GO:0050870	positive regulation of T cell activation
0.63	GO:0006468	protein phosphorylation
0.54	GO:0018212	peptidyl-tyrosine modification
0.37	GO:0022038	corpus callosum development

0.84	GO:0005003	ephrin receptor activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0008046	axon guidance receptor activity

0.65	GO:0005887	integral component of plasma membrane
0.63	GO:0009986	cell surface

sp|O15198|SMAD9_HUMAN
Mothers against decapentaplegic homolog 9
Search

SMAD9

0.65	Mothers against decapentaplegic homolog

0.83	GO:0007179	transforming growth factor beta receptor signaling pathway
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:0071773	cellular response to BMP stimulus
0.55	GO:0030901	midbrain development
0.55	GO:0060395	SMAD protein signal transduction
0.55	GO:0001657	ureteric bud development
0.54	GO:0030902	hindbrain development

0.61	GO:0003700	DNA binding transcription factor activity
0.54	GO:0003677	DNA binding
0.43	GO:0046982	protein heterodimerization activity
0.42	GO:0017151	DEAD/H-box RNA helicase binding
0.42	GO:0070410	co-SMAD binding
0.42	GO:0070878	primary miRNA binding
0.42	GO:0070411	I-SMAD binding
0.40	GO:0019901	protein kinase binding
0.39	GO:0001067	regulatory region nucleic acid binding
0.39	GO:0042803	protein homodimerization activity

0.75	GO:0005667	transcription factor complex
0.61	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.46	GO:0070013	intracellular organelle lumen
0.43	GO:0044446	intracellular organelle part
0.38	GO:0012505	endomembrane system
0.37	GO:0071141	SMAD protein complex
0.36	GO:0031090	organelle membrane
0.36	GO:0031975	envelope
0.30	GO:0016021	integral component of membrane

sp|O15204|ADEC1_HUMAN
ADAM DEC1
Search

ADAMDEC1

0.85	Metalloproteinase-disintegrin domain containing protein TECADAM

0.61	GO:0006508	proteolysis
0.49	GO:0007229	integrin-mediated signaling pathway
0.46	GO:0009405	pathogenesis
0.37	GO:0006915	apoptotic process
0.36	GO:0007162	negative regulation of cell adhesion
0.36	GO:0002376	immune system process
0.35	GO:0032501	multicellular organismal process
0.34	GO:0032270	positive regulation of cellular protein metabolic process
0.34	GO:0043085	positive regulation of catalytic activity
0.34	GO:0034241	positive regulation of macrophage fusion

0.70	GO:0004222	metalloendopeptidase activity
0.48	GO:0090729	toxin activity
0.48	GO:0046872	metal ion binding
0.34	GO:0016504	peptidase activator activity
0.34	GO:0043236	laminin binding
0.34	GO:0005178	integrin binding
0.33	GO:0005518	collagen binding
0.33	GO:0017124	SH3 domain binding

0.40	GO:0005576	extracellular region
0.39	GO:0005739	mitochondrion
0.38	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.70

GO:0004222

sp|O15205|UBD_HUMAN
Ubiquitin D
Search

UBD

0.97	LOW QUALITY PROTEIN: ubiquitin D

0.86	GO:0070842	aggresome assembly
0.85	GO:0043011	myeloid dendritic cell differentiation
0.85	GO:0034341	response to interferon-gamma
0.84	GO:0034612	response to tumor necrosis factor
0.84	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.79	GO:0043065	positive regulation of apoptotic process
0.76	GO:1901990	regulation of mitotic cell cycle phase transition
0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.73	GO:0016567	protein ubiquitination
0.46	GO:0043687	post-translational protein modification

0.82

GO:0070628

proteasome binding

0.84	GO:0016235	aggresome
0.80	GO:0001650	fibrillar center
0.46	GO:0005737	cytoplasm

sp|O15209|ZBT22_HUMAN
Zinc finger and BTB domain-containing protein 22
Search

ZBTB22

0.45	Zinc finger and BTB domain containing 9

0.37	GO:0006351	transcription, DNA-templated
0.36	GO:2001141	regulation of RNA biosynthetic process
0.36	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.36	GO:0010468	regulation of gene expression
0.33	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I
0.33	GO:0007018	microtubule-based movement

0.54	GO:0003677	DNA binding
0.36	GO:0046872	metal ion binding
0.35	GO:0005515	protein binding
0.33	GO:0003777	microtubule motor activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.60	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|O15211|RGL2_HUMAN
Ral guanine nucleotide dissociation stimulator-like 2
Search

RGL2

0.96	Ral guanine nucleotide dissociation stimulator like 2

0.76	GO:0007264	small GTPase mediated signal transduction
0.66	GO:0065009	regulation of molecular function
0.64	GO:0032485	regulation of Ral protein signal transduction
0.64	GO:0010667	negative regulation of cardiac muscle cell apoptotic process
0.61	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
0.41	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I

0.75	GO:0005085	guanyl-nucleotide exchange factor activity
0.56	GO:0017048	Rho GTPase binding
0.37	GO:0030695	GTPase regulator activity
0.36	GO:0017160	Ral GTPase binding

0.45	GO:0005622	intracellular
0.38	GO:0005903	brush border
0.34	GO:0043227	membrane-bounded organelle
0.30	GO:0016020	membrane

sp|O15212|PFD6_HUMAN
Prefoldin subunit 6
Search

PFDN6

0.93	HLA class II region expressed gene KE2

0.69	GO:0006457	protein folding
0.58	GO:0051131	chaperone-mediated protein complex assembly
0.34	GO:0007021	tubulin complex assembly
0.33	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
0.33	GO:0006470	protein dephosphorylation
0.32	GO:0006508	proteolysis

0.71	GO:0051082	unfolded protein binding
0.55	GO:0051087	chaperone binding
0.34	GO:0003723	RNA binding
0.34	GO:0046872	metal ion binding
0.33	GO:0004722	protein serine/threonine phosphatase activity
0.33	GO:0015631	tubulin binding
0.33	GO:0004252	serine-type endopeptidase activity

0.80	GO:0016272	prefoldin complex
0.37	GO:0005737	cytoplasm
0.33	GO:0005634	nucleus

0.33

GO:0004252

sp|O15213|WDR46_HUMAN
WD repeat-containing protein 46
Search

WDR46

0.93	WD repeat-containing protein 46

0.79	GO:1903955	positive regulation of protein targeting to mitochondrion
0.63	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0.33	GO:0051638	barbed-end actin filament uncapping
0.33	GO:2000813	negative regulation of barbed-end actin filament capping
0.33	GO:1902745	positive regulation of lamellipodium organization
0.33	GO:0030335	positive regulation of cell migration
0.32	GO:0030001	metal ion transport
0.32	GO:0043043	peptide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process
0.32	GO:0055085	transmembrane transport

0.39	GO:0003723	RNA binding
0.32	GO:0046873	metal ion transmembrane transporter activity
0.32	GO:0003735	structural constituent of ribosome
0.32	GO:0016491	oxidoreductase activity

0.63	GO:0030686	90S preribosome
0.61	GO:0032040	small-subunit processome
0.58	GO:0005730	nucleolus
0.41	GO:0005581	collagen trimer
0.39	GO:0005654	nucleoplasm
0.37	GO:0005840	ribosome
0.33	GO:0030027	lamellipodium
0.30	GO:0031224	intrinsic component of membrane

0.32

EC:1

GO:0016491

sp|O15217|GSTA4_HUMAN
Glutathione S-transferase A4
Search

GSTA4

0.42	Glutathione S-transferase

0.51	GO:0006749	glutathione metabolic process
0.50	GO:0006805	xenobiotic metabolic process
0.40	GO:0043390	aflatoxin B1 metabolic process
0.37	GO:0098754	detoxification
0.36	GO:1901687	glutathione derivative biosynthetic process
0.36	GO:0043651	linoleic acid metabolic process
0.35	GO:0030855	epithelial cell differentiation
0.34	GO:0097237	cellular response to toxic substance

0.76	GO:0004364	glutathione transferase activity
0.49	GO:0042803	protein homodimerization activity
0.35	GO:0004602	glutathione peroxidase activity

0.40	GO:0005829	cytosol
0.35	GO:0005615	extracellular space
0.34	GO:1903561	extracellular vesicle
0.30	GO:0016020	membrane

0.76

EC:2.5.1.18

GO:0004364

sp|O15218|GP182_HUMAN
G-protein coupled receptor 182
Search

GPR182

0.97	G-protein coupled receptor 182

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.45	GO:0035556	intracellular signal transduction
0.37	GO:0001666	response to hypoxia
0.37	GO:0007166	cell surface receptor signaling pathway

0.72	GO:0004930	G-protein coupled receptor activity
0.37	GO:0001653	peptide receptor activity

0.37	GO:0005622	intracellular
0.36	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

sp|O15225|INE1_HUMAN
Putative inactivation escape 1 protein
Search

0.40	Putative inactivation escape 1 protein

sp|O15226|NKRF_HUMAN
NF-kappa-B-repressing factor
Search

NKRF

0.95	NF-kappa-B-repressing factor

0.55	GO:0006366	transcription by RNA polymerase II
0.55	GO:0045944	positive regulation of transcription by RNA polymerase II
0.53	GO:0045892	negative regulation of transcription, DNA-templated
0.37	GO:0007165	signal transduction
0.32	GO:0000723	telomere maintenance
0.32	GO:0032392	DNA geometric change
0.31	GO:0006310	DNA recombination
0.31	GO:0006281	DNA repair

0.59	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.58	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0003723	RNA binding
0.34	GO:0005515	protein binding
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.33	GO:0032555	purine ribonucleotide binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003678	DNA helicase activity
0.31	GO:0030554	adenyl nucleotide binding

0.54	GO:0005730	nucleolus
0.39	GO:0005654	nucleoplasm

sp|O15228|GNPAT_HUMAN
Dihydroxyacetone phosphate acyltransferase
Search

GNPAT

0.96	Dihydroxyacetone phosphate acyltransferase

0.80	GO:0008611	ether lipid biosynthetic process
0.60	GO:0006650	glycerophospholipid metabolic process
0.57	GO:0030913	paranodal junction assembly
0.55	GO:0021587	cerebellum morphogenesis
0.55	GO:0007416	synapse assembly
0.47	GO:0061024	membrane organization
0.40	GO:0070542	response to fatty acid
0.39	GO:0007584	response to nutrient
0.38	GO:0042594	response to starvation
0.37	GO:0042493	response to drug

0.83	GO:0016287	glycerone-phosphate O-acyltransferase activity
0.58	GO:0016290	palmitoyl-CoA hydrolase activity
0.50	GO:0005102	receptor binding

0.70	GO:0005777	peroxisome
0.66	GO:0031903	microbody membrane
0.37	GO:0031907	microbody lumen
0.35	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.83	EC:2.3.1.42	GO:0016287
0.83	KEGG:R01013	GO:0016287

sp|O15229|KMO_HUMAN
Kynurenine 3-monooxygenase
Search

KMO

0.73	Kynurenine 3-monooxygenase

0.75	GO:0019805	quinolinate biosynthetic process
0.73	GO:0006569	tryptophan catabolic process
0.73	GO:0043420	anthranilate metabolic process
0.72	GO:0034354	'de novo' NAD biosynthetic process from tryptophan
0.54	GO:0070189	kynurenine metabolic process
0.54	GO:0009651	response to salt stress
0.52	GO:0055114	oxidation-reduction process
0.45	GO:0044550	secondary metabolite biosynthetic process
0.35	GO:0001878	response to yeast
0.35	GO:0072015	glomerular visceral epithelial cell development

0.82	GO:0004502	kynurenine 3-monooxygenase activity
0.72	GO:0071949	FAD binding
0.59	GO:0016174	NAD(P)H oxidase activity

0.68	GO:0005741	mitochondrial outer membrane
0.44	GO:0019866	organelle inner membrane
0.37	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.82	EC:1.14.13.9	GO:0004502
0.82	KEGG:R01960	GO:0004502

sp|O15230|LAMA5_HUMAN
Laminin subunit alpha-5
Search

LAMA5

0.74	Laminin subunit alpha 5

0.82	GO:0045995	regulation of embryonic development
0.78	GO:0030334	regulation of cell migration
0.75	GO:0030155	regulation of cell adhesion
0.72	GO:0007155	cell adhesion
0.56	GO:0060445	branching involved in salivary gland morphogenesis
0.55	GO:0001658	branching involved in ureteric bud morphogenesis
0.55	GO:0001755	neural crest cell migration
0.54	GO:0001738	morphogenesis of a polarized epithelium
0.54	GO:0042475	odontogenesis of dentin-containing tooth
0.54	GO:0001942	hair follicle development

0.72	GO:0005102	receptor binding
0.52	GO:0050839	cell adhesion molecule binding
0.50	GO:0032403	protein complex binding
0.32	GO:0003735	structural constituent of ribosome

0.58	GO:0043259	laminin-10 complex
0.56	GO:0043083	synaptic cleft
0.49	GO:0005615	extracellular space
0.42	GO:0005610	laminin-5 complex
0.36	GO:1903561	extracellular vesicle
0.35	GO:0043260	laminin-11 complex
0.35	GO:0005783	endoplasmic reticulum
0.34	GO:0005634	nucleus
0.32	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

sp|O15231|ZN185_HUMAN
Zinc finger protein 185
Search

0.63	Zinc finger protein 185 with LIM domain

0.78	GO:0051015	actin filament binding
0.53	GO:0046872	metal ion binding

0.74	GO:0015629	actin cytoskeleton
0.38	GO:0005925	focal adhesion
0.33	GO:0005737	cytoplasm

sp|O15232|MATN3_HUMAN
Matrilin-3
Search

0.56	Matrilin 3

0.51	GO:0051216	cartilage development
0.39	GO:0003416	endochondral bone growth
0.39	GO:0060350	endochondral bone morphogenesis
0.39	GO:0030500	regulation of bone mineralization
0.38	GO:0000904	cell morphogenesis involved in differentiation
0.38	GO:0048729	tissue morphogenesis
0.30	GO:0043687	post-translational protein modification
0.30	GO:0030198	extracellular matrix organization

0.70	GO:0005201	extracellular matrix structural constituent
0.68	GO:0005509	calcium ion binding
0.30	GO:0005515	protein binding

0.65	GO:0005578	proteinaceous extracellular matrix
0.30	GO:0016020	membrane
0.30	GO:0044464	cell part
0.30	GO:0031974	membrane-enclosed lumen
0.30	GO:0044422	organelle part
0.30	GO:0043227	membrane-bounded organelle

sp|O15234|CASC3_HUMAN
Protein CASC3
Search

CASC3

0.97	Cancer susceptibility candidate 3

0.70	GO:0006397	mRNA processing
0.58	GO:0008298	intracellular mRNA localization
0.43	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.41	GO:0051028	mRNA transport
0.41	GO:0008380	RNA splicing
0.40	GO:0006417	regulation of translation
0.36	GO:0007264	small GTPase mediated signal transduction
0.36	GO:0006369	termination of RNA polymerase II transcription
0.36	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.35	GO:0031123	RNA 3'-end processing

0.59	GO:0003723	RNA binding
0.56	GO:0031625	ubiquitin protein ligase binding
0.53	GO:0042802	identical protein binding
0.36	GO:0005085	guanyl-nucleotide exchange factor activity
0.34	GO:0003779	actin binding
0.32	GO:0052861	glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group
0.31	GO:0008270	zinc ion binding
0.31	GO:0003700	DNA binding transcription factor activity

0.85	GO:0035145	exon-exon junction complex
0.55	GO:0031965	nuclear membrane
0.46	GO:0030529	intracellular ribonucleoprotein complex
0.42	GO:0030425	dendrite
0.42	GO:0016607	nuclear speck
0.42	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0043232	intracellular non-membrane-bounded organelle
0.35	GO:0005829	cytosol

0.32

EC:3.2.1.6

GO:0052861

sp|O15235|RT12_HUMAN
28S ribosomal protein S12, mitochondrial
Search

MRPS12

0.97	Mitochondrial ribosomal protein S12

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.34	GO:0043624	cellular protein complex disassembly

0.64	GO:0003735	structural constituent of ribosome
0.34	GO:0003723	RNA binding
0.33	GO:0005515	protein binding
0.32	GO:0016746	transferase activity, transferring acyl groups
0.32	GO:0016787	hydrolase activity

0.70	GO:0015935	small ribosomal subunit
0.53	GO:0005761	mitochondrial ribosome
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0019866	organelle inner membrane
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016746

sp|O15239|NDUA1_HUMAN
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Search

NDUFA1

0.42	Mitochondrial NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

0.65	GO:0032981	mitochondrial respiratory chain complex I assembly
0.38	GO:0055114	oxidation-reduction process
0.37	GO:0016310	phosphorylation
0.35	GO:0046034	ATP metabolic process
0.34	GO:0006091	generation of precursor metabolites and energy

0.37	GO:0003954	NADH dehydrogenase activity
0.37	GO:0016301	kinase activity
0.36	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

0.63	GO:0005747	mitochondrial respiratory chain complex I
0.54	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.37

EC:1.6.99.3

GO:0003954

sp|O15240|VGF_HUMAN
Neurosecretory protein VGF
Search

VGF

0.96	VGF nerve growth factor inducible

0.75	GO:0010469	regulation of receptor activity
0.65	GO:0002021	response to dietary excess
0.65	GO:0051591	response to cAMP
0.65	GO:0030073	insulin secretion
0.63	GO:0001541	ovarian follicle development
0.63	GO:0033500	carbohydrate homeostasis
0.62	GO:0032868	response to insulin
0.60	GO:0009409	response to cold
0.58	GO:0019953	sexual reproduction
0.54	GO:0048167	regulation of synaptic plasticity

0.85	GO:0005184	neuropeptide hormone activity
0.44	GO:0008083	growth factor activity
0.32	GO:0017111	nucleoside-triphosphatase activity
0.32	GO:0004222	metalloendopeptidase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.31	GO:0003676	nucleic acid binding
0.31	GO:0046872	metal ion binding

0.59	GO:0005615	extracellular space
0.57	GO:0031410	cytoplasmic vesicle
0.55	GO:0005794	Golgi apparatus
0.40	GO:0005788	endoplasmic reticulum lumen
0.38	GO:0043025	neuronal cell body
0.38	GO:0043005	neuron projection
0.38	GO:0012506	vesicle membrane
0.37	GO:0098805	whole membrane
0.37	GO:0098588	bounding membrane of organelle
0.32	GO:0005634	nucleus

0.32

EC:3.6.1.15

GO:0017111

sp|O15243|OBRG_HUMAN
Leptin receptor gene-related protein
Search

LEPROT

0.97	Leptin receptor overlapping transcript

0.51	GO:2000009	negative regulation of protein localization to cell surface
0.50	GO:0060400	negative regulation of growth hormone receptor signaling pathway
0.49	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway
0.47	GO:0046426	negative regulation of JAK-STAT cascade
0.38	GO:1903955	positive regulation of protein targeting to mitochondrion
0.32	GO:0005975	carbohydrate metabolic process

0.43	GO:0005102	receptor binding
0.33	GO:0016868	intramolecular transferase activity, phosphotransferases
0.33	GO:0000287	magnesium ion binding

0.46	GO:0005768	endosome
0.40	GO:0044433	cytoplasmic vesicle part
0.40	GO:0000139	Golgi membrane
0.39	GO:0098805	whole membrane
0.30	GO:0016021	integral component of membrane

0.33

EC:5.4.2

GO:0016868

sp|O15244|S22A2_HUMAN
Solute carrier family 22 member 2
Search

SLC22A2

0.96	Solute carrier family 22 member 2

0.58	GO:0015695	organic cation transport
0.55	GO:0015872	dopamine transport
0.55	GO:0015874	norepinephrine transport
0.55	GO:0055085	transmembrane transport
0.54	GO:1901374	acetate ester transport
0.47	GO:0006836	neurotransmitter transport
0.46	GO:0015711	organic anion transport
0.39	GO:0048241	epinephrine transport
0.36	GO:0051260	protein homooligomerization
0.35	GO:0007589	body fluid secretion

0.60	GO:0015101	organic cation transmembrane transporter activity
0.56	GO:0005329	dopamine transmembrane transporter activity
0.55	GO:0005333	norepinephrine transmembrane transporter activity
0.55	GO:1901375	acetate ester transmembrane transporter activity
0.48	GO:0005326	neurotransmitter transporter activity
0.47	GO:0008514	organic anion transmembrane transporter activity
0.45	GO:0015291	secondary active transmembrane transporter activity
0.36	GO:0042803	protein homodimerization activity
0.35	GO:0005496	steroid binding

0.45	GO:0005887	integral component of plasma membrane
0.40	GO:0016323	basolateral plasma membrane
0.36	GO:0070062	extracellular exosome
0.35	GO:0098793	presynapse

sp|O15245|S22A1_HUMAN
Solute carrier family 22 member 1
Search

SLC22A1

0.96	Solute carrier family 22 member 1 isoform a

0.58	GO:0015695	organic cation transport
0.55	GO:0015872	dopamine transport
0.55	GO:0015874	norepinephrine transport
0.55	GO:0055085	transmembrane transport
0.54	GO:1901374	acetate ester transport
0.48	GO:0006836	neurotransmitter transport
0.46	GO:0015711	organic anion transport
0.40	GO:0048241	epinephrine transport
0.37	GO:0051260	protein homooligomerization
0.35	GO:0007589	body fluid secretion

0.60	GO:0015101	organic cation transmembrane transporter activity
0.56	GO:0005329	dopamine transmembrane transporter activity
0.55	GO:0005333	norepinephrine transmembrane transporter activity
0.55	GO:1901375	acetate ester transmembrane transporter activity
0.48	GO:0005326	neurotransmitter transporter activity
0.47	GO:0008514	organic anion transmembrane transporter activity
0.45	GO:0015291	secondary active transmembrane transporter activity
0.37	GO:0042803	protein homodimerization activity
0.34	GO:0005496	steroid binding

0.45	GO:0005887	integral component of plasma membrane
0.41	GO:0016323	basolateral plasma membrane
0.36	GO:0070062	extracellular exosome
0.34	GO:0098793	presynapse

sp|O15247|CLIC2_HUMAN
Chloride intracellular channel protein 2
Search

CLIC2

0.82	LOW QUALITY PROTEIN: chloride intracellular channel protein 2

0.81	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
0.75	GO:1902476	chloride transmembrane transport
0.54	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
0.51	GO:0051099	positive regulation of binding
0.46	GO:0098869	cellular oxidant detoxification
0.43	GO:0006749	glutathione metabolic process
0.38	GO:0060088	auditory receptor cell stereocilium organization
0.37	GO:0002024	diet induced thermogenesis
0.37	GO:0007605	sensory perception of sound
0.37	GO:0050885	neuromuscular process controlling balance

0.76	GO:0005254	chloride channel activity
0.66	GO:0022832	voltage-gated channel activity
0.64	GO:0022839	ion gated channel activity
0.64	GO:0008381	mechanosensitive ion channel activity
0.50	GO:0004602	glutathione peroxidase activity
0.44	GO:0004364	glutathione transferase activity
0.35	GO:0031751	D4 dopamine receptor binding
0.35	GO:0031749	D2 dopamine receptor binding
0.35	GO:0031750	D3 dopamine receptor binding
0.34	GO:0008022	protein C-terminus binding

0.72	GO:0034707	chloride channel complex
0.46	GO:0005737	cytoplasm
0.39	GO:0005634	nucleus
0.37	GO:0032420	stereocilium
0.34	GO:0015629	actin cytoskeleton
0.34	GO:0070062	extracellular exosome
0.32	GO:0005886	plasma membrane

0.50

EC:1.11.1.9

GO:0004602

sp|O15254|ACOX3_HUMAN
Peroxisomal acyl-coenzyme A oxidase 3
Search

ACOX3

0.61	Acyl-coenzyme A oxidase

0.75

GO:0006635

fatty acid beta-oxidation

0.81	GO:0003997	acyl-CoA oxidase activity
0.71	GO:0071949	FAD binding
0.49	GO:0005102	receptor binding
0.46	GO:0003995	acyl-CoA dehydrogenase activity
0.35	GO:0005504	fatty acid binding

0.74	GO:0042579	microbody
0.44	GO:0005739	mitochondrion
0.35	GO:0070013	intracellular organelle lumen
0.34	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.81

EC:1.3.3.6

GO:0003997

sp|O15255|CXX1_HUMAN
CAAX box protein 1
Search

0.40	CAAX box protein 1

0.56

GO:0005886

plasma membrane

sp|O15258|RER1_HUMAN
Protein RER1
Search

RER1

0.88	Retention in endoplasmic reticulum sorting receptor 1

0.57	GO:0071340	skeletal muscle acetylcholine-gated channel clustering
0.55	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.54	GO:1903078	positive regulation of protein localization to plasma membrane
0.40	GO:0060271	cilium assembly
0.35	GO:0016558	protein import into peroxisome matrix

0.56

GO:0033130

acetylcholine receptor binding

0.53	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.53	GO:0030173	integral component of Golgi membrane
0.50	GO:0009986	cell surface
0.41	GO:0005886	plasma membrane
0.34	GO:0005777	peroxisome

sp|O15259|NPHP1_HUMAN
Nephrocystin-1
Search

NPHP1

0.90	Nephronophthisis 1

0.85	GO:1903348	positive regulation of bicellular tight junction assembly
0.53	GO:0048793	pronephros development
0.48	GO:0007283	spermatogenesis
0.48	GO:0060041	retina development in camera-type eye
0.46	GO:0022412	cellular process involved in reproduction in multicellular organism
0.45	GO:0030154	cell differentiation
0.45	GO:0003006	developmental process involved in reproduction
0.45	GO:0030030	cell projection organization
0.44	GO:0007588	excretion
0.43	GO:0007632	visual behavior

0.42	GO:0005515	protein binding
0.38	GO:0005198	structural molecule activity
0.37	GO:0005245	voltage-gated calcium channel activity
0.34	GO:0005509	calcium ion binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.72	GO:0031514	motile cilium
0.70	GO:0005911	cell-cell junction
0.49	GO:0032391	photoreceptor connecting cilium
0.46	GO:0005912	adherens junction
0.44	GO:0097546	ciliary base
0.43	GO:0005856	cytoskeleton
0.39	GO:0005829	cytosol
0.37	GO:0005891	voltage-gated calcium channel complex
0.34	GO:0005578	proteinaceous extracellular matrix

sp|O15260|SURF4_HUMAN
Surfeit locus protein 4
Search

SURF4

0.97	Surfeit gene 4

0.50	GO:0007030	Golgi organization
0.48	GO:0010638	positive regulation of organelle organization
0.38	GO:0034498	early endosome to Golgi transport
0.38	GO:0032527	protein exit from endoplasmic reticulum
0.35	GO:0043312	neutrophil degranulation
0.34	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER

0.34

GO:0005515

protein binding

0.51	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.39	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0000139	Golgi membrane
0.35	GO:0035577	azurophil granule membrane
0.34	GO:0030133	transport vesicle
0.33	GO:0031966	mitochondrial membrane
0.33	GO:0019866	organelle inner membrane
0.32	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O15263|DFB4A_HUMAN
Beta-defensin 4A
Search

0.85	Beta-defensin 4A

0.85	GO:0050830	defense response to Gram-positive bacterium
0.84	GO:0050829	defense response to Gram-negative bacterium
0.71	GO:0006935	chemotaxis
0.64	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
0.59	GO:0031640	killing of cells of other organism
0.54	GO:0007186	G-protein coupled receptor signaling pathway

0.88

GO:0031731

CCR6 chemokine receptor binding

0.66	GO:0005576	extracellular region
0.65	GO:0005796	Golgi lumen

sp|O15264|MK13_HUMAN
Mitogen-activated protein kinase 13
Search

MAPK13

0.58	Mitogen-activated protein kinase

0.79	GO:0000165	MAPK cascade
0.53	GO:0032755	positive regulation of interleukin-6 production
0.53	GO:0018105	peptidyl-serine phosphorylation
0.51	GO:0006970	response to osmotic stress
0.40	GO:0045445	myoblast differentiation
0.39	GO:0060255	regulation of macromolecule metabolic process
0.38	GO:0007049	cell cycle
0.36	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.36	GO:0006351	transcription, DNA-templated
0.36	GO:0080090	regulation of primary metabolic process

0.81	GO:0004707	MAP kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0000287	magnesium ion binding
0.34	GO:0005515	protein binding

0.45	GO:0005622	intracellular
0.38	GO:0043227	membrane-bounded organelle
0.34	GO:0043233	organelle lumen

0.81	EC:2.7.11.24	GO:0004707
0.81	KEGG:R00162	GO:0004707

sp|O15265|ATX7_HUMAN
Ataxin-7
Search

ATXN7

0.97	Ataxin-7 isoform c

0.85	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway
0.81	GO:0016578	histone deubiquitination
0.73	GO:0000226	microtubule cytoskeleton organization
0.71	GO:0045944	positive regulation of transcription by RNA polymerase II
0.71	GO:0042326	negative regulation of phosphorylation
0.53	GO:0021707	cerebellar granule cell differentiation
0.53	GO:0021702	cerebellar Purkinje cell differentiation
0.50	GO:0046530	photoreceptor cell differentiation
0.49	GO:0043009	chordate embryonic development
0.41	GO:0006997	nucleus organization

0.73	GO:0003682	chromatin binding
0.40	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.40	GO:0005515	protein binding

0.68	GO:0015630	microtubule cytoskeleton
0.67	GO:0005654	nucleoplasm
0.66	GO:0005829	cytosol
0.45	GO:0016363	nuclear matrix
0.42	GO:0005730	nucleolus

0.40

GO:0036459

sp|O15266|SHOX_HUMAN
Short stature homeobox protein
Search

SHOX

0.95	Short stature homeobox transcript variant SHOXa

0.62	GO:0007275	multicellular organism development
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.49	GO:0001503	ossification
0.47	GO:2000172	regulation of branching morphogenesis of a nerve
0.47	GO:0048743	positive regulation of skeletal muscle fiber development
0.47	GO:0051254	positive regulation of RNA metabolic process
0.46	GO:0010557	positive regulation of macromolecule biosynthetic process
0.46	GO:0031328	positive regulation of cellular biosynthetic process

0.63	GO:0043565	sequence-specific DNA binding
0.44	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.34	GO:0005515	protein binding
0.34	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding

0.61	GO:0005634	nucleus
0.41	GO:0031974	membrane-enclosed lumen
0.38	GO:0044446	intracellular organelle part

sp|O15269|SPTC1_HUMAN
Serine palmitoyltransferase 1
Search

SPTLC1

0.90	Serine palmitoyltransferase long chain base subunit 1

0.57	GO:1904502	regulation of lipophagy
0.55	GO:0046513	ceramide biosynthetic process
0.54	GO:0016239	positive regulation of macroautophagy
0.53	GO:0046511	sphinganine biosynthetic process
0.52	GO:0006686	sphingomyelin biosynthetic process
0.52	GO:0046512	sphingosine biosynthetic process
0.34	GO:0006298	mismatch repair

0.67	GO:0030170	pyridoxal phosphate binding
0.57	GO:0016454	C-palmitoyltransferase activity
0.34	GO:0005515	protein binding
0.34	GO:0030983	mismatched DNA binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.57	GO:0035339	SPOTS complex
0.30	GO:0016021	integral component of membrane

0.57

GO:0016454

sp|O15270|SPTC2_HUMAN
Serine palmitoyltransferase 2
Search

SPTLC2

0.85	Serine palmitoyltransferase long chain base subunit 2

0.61	GO:0046511	sphinganine biosynthetic process
0.60	GO:0006686	sphingomyelin biosynthetic process
0.60	GO:1904502	regulation of lipophagy
0.59	GO:0046512	sphingosine biosynthetic process
0.57	GO:0046513	ceramide biosynthetic process
0.56	GO:0016239	positive regulation of macroautophagy

0.67	GO:0030170	pyridoxal phosphate binding
0.59	GO:0004758	serine C-palmitoyltransferase activity

0.58	GO:0017059	serine C-palmitoyltransferase complex
0.45	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.59	EC:2.3.1.50	GO:0004758
0.59	KEGG:R01281	GO:0004758

sp|O15273|TELT_HUMAN
Telethonin
Search

TCAP

0.97	Telethonin

0.86	GO:0048769	sarcomerogenesis
0.86	GO:0035995	detection of muscle stretch
0.86	GO:0030241	skeletal muscle myosin thick filament assembly
0.86	GO:0048739	cardiac muscle fiber development
0.86	GO:0007512	adult heart development
0.85	GO:0030240	skeletal muscle thin filament assembly
0.85	GO:0030916	otic vesicle formation
0.85	GO:0003299	muscle hypertrophy in response to stress
0.85	GO:0014887	cardiac muscle adaptation
0.85	GO:0055003	cardiac myofibril assembly

0.87	GO:0070080	titin Z domain binding
0.86	GO:0051373	FATZ binding
0.85	GO:0031432	titin binding
0.85	GO:0036122	BMP binding
0.85	GO:0008307	structural constituent of muscle
0.82	GO:0044325	ion channel binding
0.78	GO:0030674	protein binding, bridging

0.84	GO:0030018	Z disc
0.38	GO:0005829	cytosol

sp|O15287|FANCG_HUMAN
Fanconi anemia group G protein
Search

FANCG

0.97	Fanconi anemia complementation group G

0.82	GO:0001541	ovarian follicle development
0.79	GO:0007286	spermatid development
0.72	GO:0009314	response to radiation
0.71	GO:0007005	mitochondrion organization
0.62	GO:0006974	cellular response to DNA damage stimulus
0.39	GO:0006259	DNA metabolic process

0.44	GO:0005515	protein binding
0.40	GO:0003684	damaged DNA binding

0.81	GO:0043240	Fanconi anaemia nuclear complex
0.71	GO:0005730	nucleolus
0.66	GO:0005829	cytosol
0.58	GO:0005739	mitochondrion
0.54	GO:0005886	plasma membrane

sp|O15294|OGT1_HUMAN
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Search

OGT

0.87	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase subunit

0.80	GO:0006493	protein O-linked glycosylation
0.57	GO:0061087	positive regulation of histone H3-K27 methylation
0.56	GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis
0.56	GO:0043982	histone H4-K8 acetylation
0.56	GO:0043981	histone H4-K5 acetylation
0.56	GO:0035020	regulation of Rac protein signal transduction
0.55	GO:0080182	histone H3-K4 trimethylation
0.55	GO:0043984	histone H4-K16 acetylation
0.55	GO:0006110	regulation of glycolytic process
0.54	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.56	GO:0043996	histone acetyltransferase activity (H4-K8 specific)
0.56	GO:0046972	histone acetyltransferase activity (H4-K16 specific)
0.56	GO:0043995	histone acetyltransferase activity (H4-K5 specific)
0.55	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.44	GO:0140096	catalytic activity, acting on a protein
0.35	GO:0005515	protein binding
0.34	GO:0042277	peptide binding
0.34	GO:0048029	monosaccharide binding

0.50	GO:0000123	histone acetyltransferase complex
0.47	GO:0005829	cytosol
0.42	GO:0043234	protein complex
0.41	GO:0005886	plasma membrane
0.35	GO:0042588	zymogen granule
0.35	GO:0000791	euchromatin
0.34	GO:0043025	neuronal cell body
0.34	GO:0043005	neuron projection
0.34	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

0.65

GO:0016757

sp|O15296|LX15B_HUMAN
Arachidonate 15-lipoxygenase B
Search

0.91	Epidermis-type lipoxygenase 3

0.68	GO:0019372	lipoxygenase pathway
0.68	GO:0043651	linoleic acid metabolic process
0.66	GO:0019369	arachidonic acid metabolic process
0.62	GO:0051047	positive regulation of secretion
0.59	GO:0051240	positive regulation of multicellular organismal process
0.58	GO:0010744	positive regulation of macrophage derived foam cell differentiation
0.58	GO:0090196	regulation of chemokine secretion
0.58	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway
0.57	GO:0045606	positive regulation of epidermal cell differentiation
0.56	GO:0045616	regulation of keratinocyte differentiation

0.75	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
0.62	GO:0005506	iron ion binding
0.49	GO:0005509	calcium ion binding
0.39	GO:0016853	isomerase activity
0.39	GO:0008289	lipid binding
0.34	GO:0005515	protein binding

0.51	GO:0019898	extrinsic component of membrane
0.49	GO:0005829	cytosol
0.48	GO:0005856	cytoskeleton
0.42	GO:0005886	plasma membrane
0.39	GO:0070062	extracellular exosome
0.35	GO:0005634	nucleus

0.75

EC:1.13.11

GO:0016702

sp|O15297|PPM1D_HUMAN
Protein phosphatase 1D
Search

PPM1D

0.97	Protein phosphatase 1D magnesium-dependent, delta isoform

0.72	GO:0006470	protein dephosphorylation
0.59	GO:0000086	G2/M transition of mitotic cell cycle
0.56	GO:0006342	chromatin silencing
0.54	GO:0009617	response to bacterium
0.52	GO:0006306	DNA methylation
0.40	GO:0009267	cellular response to starvation
0.35	GO:0006367	transcription initiation from RNA polymerase II promoter
0.35	GO:0008285	negative regulation of cell proliferation
0.35	GO:0006468	protein phosphorylation
0.35	GO:0009314	response to radiation

0.77	GO:0004722	protein serine/threonine phosphatase activity
0.60	GO:0051019	mitogen-activated protein kinase binding
0.49	GO:0046872	metal ion binding
0.36	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0003677	DNA binding

0.49	GO:0005829	cytosol
0.46	GO:0005634	nucleus
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part

0.36

GO:0004674

sp|O15303|GRM6_HUMAN
Metabotropic glutamate receptor 6
Search

0.76	Metabotropic glutamate receptor

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.60	GO:0050908	detection of light stimulus involved in visual perception
0.58	GO:0007215	glutamate receptor signaling pathway
0.57	GO:0090280	positive regulation of calcium ion import
0.53	GO:0051966	regulation of synaptic transmission, glutamatergic
0.51	GO:0060041	retina development in camera-type eye
0.50	GO:0007626	locomotory behavior
0.39	GO:0007268	chemical synaptic transmission
0.35	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
0.35	GO:0019220	regulation of phosphate metabolic process

0.71	GO:0004930	G-protein coupled receptor activity
0.59	GO:0008066	glutamate receptor activity
0.50	GO:0042803	protein homodimerization activity

0.55	GO:0005886	plasma membrane
0.54	GO:0035841	new growing cell tip
0.50	GO:0000139	Golgi membrane
0.50	GO:0098793	presynapse
0.49	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0036477	somatodendritic compartment
0.39	GO:0043005	neuron projection
0.38	GO:0120038	plasma membrane bounded cell projection part
0.36	GO:0098794	postsynapse
0.34	GO:0044297	cell body

sp|O15304|SIVA_HUMAN
Apoptosis regulatory protein Siva
Search

SIVA1

0.93	SIVA1 apoptosis inducing factor

0.85	GO:0097191	extrinsic apoptotic signaling pathway
0.64	GO:0030260	entry into host cell
0.61	GO:0019058	viral life cycle

0.88	GO:0005175	CD27 receptor binding
0.83	GO:0104005	hijacked molecular function
0.78	GO:0005164	tumor necrosis factor receptor binding

0.70

GO:0005654

nucleoplasm

sp|O15305|PMM2_HUMAN
Phosphomannomutase 2
Search

PMM2

0.56	Phosphomannomutase

0.81	GO:0009298	GDP-mannose biosynthetic process
0.49	GO:0006487	protein N-linked glycosylation
0.48	GO:0006013	mannose metabolic process
0.46	GO:0045047	protein targeting to ER
0.41	GO:0090171	chondrocyte morphogenesis
0.39	GO:0048701	embryonic cranial skeleton morphogenesis
0.38	GO:1990830	cellular response to leukemia inhibitory factor
0.37	GO:0022008	neurogenesis
0.36	GO:0019853	L-ascorbic acid biosynthetic process
0.35	GO:0009651	response to salt stress

0.83	GO:0004615	phosphomannomutase activity
0.34	GO:0005515	protein binding
0.32	GO:0046872	metal ion binding

0.52	GO:0043025	neuronal cell body
0.50	GO:0005829	cytosol
0.44	GO:0005634	nucleus
0.36	GO:0070062	extracellular exosome

0.83	EC:5.4.2.8	GO:0004615
0.83	KEGG:R01818	GO:0004615

sp|O15315|RA51B_HUMAN
DNA repair protein RAD51 homolog 2
Search

RAD51B

0.97	DNA repair protein RAD51 like protein 2

0.77	GO:0000724	double-strand break repair via homologous recombination
0.53	GO:0001832	blastocyst growth
0.53	GO:0061053	somite development
0.52	GO:0042148	strand invasion
0.51	GO:0090735	DNA repair complex assembly
0.51	GO:0006312	mitotic recombination
0.50	GO:0008284	positive regulation of cell proliferation
0.50	GO:0010212	response to ionizing radiation
0.50	GO:0007131	reciprocal meiotic recombination
0.48	GO:0065004	protein-DNA complex assembly

0.69	GO:0008094	DNA-dependent ATPase activity
0.55	GO:0003677	DNA binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0000150	recombinase activity
0.46	GO:0004520	endodeoxyribonuclease activity
0.34	GO:0005515	protein binding
0.32	GO:0008270	zinc ion binding

0.85	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex
0.47	GO:0005657	replication fork
0.35	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

sp|O15318|RPC7_HUMAN
DNA-directed RNA polymerase III subunit RPC7
Search

POLR3G

0.93	RNA polymerase III subunit G

0.81	GO:0006383	transcription by RNA polymerase III
0.57	GO:0032728	positive regulation of interferon-beta production
0.55	GO:0008283	cell proliferation
0.54	GO:0045089	positive regulation of innate immune response
0.37	GO:0045087	innate immune response
0.37	GO:0051607	defense response to virus
0.35	GO:0006359	regulation of transcription by RNA polymerase III

0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.34	GO:0005515	protein binding

0.57	GO:0005666	DNA-directed RNA polymerase III complex
0.57	GO:0000790	nuclear chromatin
0.35	GO:0005829	cytosol

0.70

GO:0003899

sp|O15320|CTGE5_HUMAN
cTAGE family member 5
Search

CTAGE5

0.84	Cutaneous T-cell lymphoma-associated antigen 5

0.30

GO:0044425

membrane part

sp|O15321|TM9S1_HUMAN
Transmembrane 9 superfamily member 1
Search

TM9SF1

0.54	Transmembrane 9 superfamily member

0.46	GO:0007034	vacuolar transport
0.40	GO:0006914	autophagy
0.36	GO:0006886	intracellular protein transport
0.33	GO:0008654	phospholipid biosynthetic process
0.32	GO:0006518	peptide metabolic process
0.32	GO:0043604	amide biosynthetic process
0.31	GO:0044267	cellular protein metabolic process
0.31	GO:1901566	organonitrogen compound biosynthetic process
0.31	GO:0010467	gene expression
0.31	GO:0009059	macromolecule biosynthetic process

0.38	GO:0008536	Ran GTPase binding
0.33	GO:0016780	phosphotransferase activity, for other substituted phosphate groups
0.32	GO:0003735	structural constituent of ribosome
0.32	GO:0003723	RNA binding

0.42	GO:0000421	autophagosome membrane
0.40	GO:0005765	lysosomal membrane
0.39	GO:0031410	cytoplasmic vesicle
0.32	GO:0015935	small ribosomal subunit
0.30	GO:0016021	integral component of membrane

0.33

EC:2.7.8

GO:0016780

sp|O15327|INP4B_HUMAN
Type II inositol 3,4-bisphosphate 4-phosphatase
Search

INPP4B

0.92	Inositol polyphosphate-4-phosphatase type II B

0.69	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
0.49	GO:0007165	signal transduction
0.44	GO:0016311	dephosphorylation
0.44	GO:0045671	negative regulation of osteoclast differentiation
0.43	GO:0046850	regulation of bone remodeling
0.43	GO:0051896	regulation of protein kinase B signaling
0.42	GO:0046822	regulation of nucleocytoplasmic transport
0.42	GO:0006874	cellular calcium ion homeostasis
0.42	GO:0043647	inositol phosphate metabolic process
0.38	GO:0046174	polyol catabolic process

0.76	GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
0.52	GO:0034597	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
0.44	GO:0034594	phosphatidylinositol trisphosphate phosphatase activity
0.43	GO:0052828	inositol-3,4-bisphosphate 4-phosphatase activity
0.43	GO:0017161	inositol-1,3,4-trisphosphate 4-phosphatase activity
0.40	GO:0008289	lipid binding
0.37	GO:0004984	olfactory receptor activity
0.36	GO:0005515	protein binding

0.43	GO:0005737	cytoplasm
0.39	GO:0012505	endomembrane system
0.36	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016020	membrane

0.76

EC:3.1.3.66

GO:0016316

sp|O15335|CHAD_HUMAN
Chondroadherin
Search

CHAD

0.97	Chondroadherin

0.84	GO:1900155	negative regulation of bone trabecula formation
0.75	GO:0060348	bone development
0.64	GO:0046426	negative regulation of JAK-STAT cascade
0.60	GO:0006469	negative regulation of protein kinase activity
0.60	GO:0019221	cytokine-mediated signaling pathway
0.57	GO:1904027	negative regulation of collagen fibril organization
0.54	GO:0032331	negative regulation of chondrocyte differentiation
0.40	GO:0001502	cartilage condensation
0.34	GO:0007409	axonogenesis
0.33	GO:0006468	protein phosphorylation

0.62	GO:0004860	protein kinase inhibitor activity
0.57	GO:0098633	collagen fibril binding
0.52	GO:0005518	collagen binding
0.33	GO:0004674	protein serine/threonine kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.53	GO:0031012	extracellular matrix
0.41	GO:0005737	cytoplasm
0.32	GO:0005615	extracellular space
0.30	GO:0016020	membrane

0.33

GO:0004674

sp|O15342|VA0E1_HUMAN
V-type proton ATPase subunit e 1
Search

ATP6V0E1

0.67	V-type proton ATPase subunit

0.76	GO:0015991	ATP hydrolysis coupled proton transport
0.37	GO:0090383	phagosome acidification
0.37	GO:0010243	response to organonitrogen compound
0.37	GO:0033572	transferrin transport
0.36	GO:0007035	vacuolar acidification
0.36	GO:0016241	regulation of macroautophagy
0.36	GO:1901700	response to oxygen-containing compound
0.36	GO:1901699	cellular response to nitrogen compound
0.36	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.35	GO:0032870	cellular response to hormone stimulus

0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.56	GO:0036442	proton-exporting ATPase activity
0.51	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
0.33	GO:0046983	protein dimerization activity
0.32	GO:0003676	nucleic acid binding

0.78	GO:0033179	proton-transporting V-type ATPase, V0 domain
0.37	GO:0030670	phagocytic vesicle membrane
0.36	GO:0010008	endosome membrane
0.33	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

sp|O15344|TRI18_HUMAN
E3 ubiquitin-protein ligase Midline-1
Search

MID1

0.97	E3 ubiquitin-protein ligase Midline-1

0.58	GO:0035372	protein localization to microtubule
0.54	GO:0032874	positive regulation of stress-activated MAPK cascade
0.51	GO:0007026	negative regulation of microtubule depolymerization
0.36	GO:0045087	innate immune response
0.35	GO:0046597	negative regulation of viral entry into host cell
0.35	GO:1902187	negative regulation of viral release from host cell
0.35	GO:0032897	negative regulation of viral transcription
0.34	GO:0019221	cytokine-mediated signaling pathway
0.34	GO:0007389	pattern specification process
0.34	GO:0051092	positive regulation of NF-kappaB transcription factor activity

0.61	GO:0008270	zinc ion binding
0.55	GO:0051219	phosphoprotein binding
0.52	GO:0031625	ubiquitin protein ligase binding
0.51	GO:0042803	protein homodimerization activity
0.50	GO:0008017	microtubule binding
0.50	GO:0046982	protein heterodimerization activity
0.47	GO:0016874	ligase activity
0.34	GO:0016740	transferase activity

0.54	GO:0005881	cytoplasmic microtubule
0.34	GO:0005819	spindle
0.34	GO:0005875	microtubule associated complex
0.34	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.47

GO:0016874

sp|O15347|HMGB3_HUMAN
High mobility group protein B3
Search

HMGB3

0.96	High mobility group box 3

0.56	GO:0032392	DNA geometric change
0.52	GO:0045578	negative regulation of B cell differentiation
0.49	GO:0045638	negative regulation of myeloid cell differentiation
0.38	GO:0045087	innate immune response
0.35	GO:0006351	transcription, DNA-templated
0.34	GO:2001141	regulation of RNA biosynthetic process
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression
0.34	GO:0006310	DNA recombination
0.33	GO:0007275	multicellular organism development

0.67	GO:0000400	four-way junction DNA binding
0.67	GO:0008301	DNA binding, bending
0.40	GO:0003723	RNA binding
0.35	GO:0003690	double-stranded DNA binding
0.33	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.36	GO:0005694	chromosome
0.33	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O15350|P73_HUMAN
Tumor protein p73
Search

TP73

0.97	Tumor protein p73 isoform a

0.76	GO:0007050	cell cycle arrest
0.76	GO:0051262	protein tetramerization
0.74	GO:0006915	apoptotic process
0.59	GO:0060044	negative regulation of cardiac muscle cell proliferation
0.58	GO:0072331	signal transduction by p53 class mediator
0.57	GO:0071158	positive regulation of cell cycle arrest
0.55	GO:2001141	regulation of RNA biosynthetic process
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.53	GO:0007346	regulation of mitotic cell cycle

0.72	GO:0044212	transcription regulatory region DNA binding
0.60	GO:0097371	MDM2/MDM4 family protein binding
0.59	GO:0003700	DNA binding transcription factor activity
0.58	GO:0002039	p53 binding
0.53	GO:0019901	protein kinase binding
0.51	GO:0003690	double-stranded DNA binding
0.51	GO:0042802	identical protein binding
0.50	GO:0008134	transcription factor binding
0.48	GO:0043565	sequence-specific DNA binding
0.46	GO:0003682	chromatin binding

0.59	GO:0005634	nucleus
0.52	GO:0030054	cell junction
0.50	GO:0005794	Golgi apparatus
0.48	GO:0070013	intracellular organelle lumen
0.46	GO:0005667	transcription factor complex
0.45	GO:0000785	chromatin
0.43	GO:0005829	cytosol
0.34	GO:0005791	rough endoplasmic reticulum
0.34	GO:0030425	dendrite
0.33	GO:0005739	mitochondrion

sp|O15353|FOXN1_HUMAN
Forkhead box protein N1
Search

FOXN1

0.97	Winged-helix transcription factor nude

0.68	GO:0097536	thymus epithelium morphogenesis
0.68	GO:1902232	regulation of positive thymic T cell selection
0.67	GO:0097535	lymphoid lineage cell migration into thymus
0.66	GO:0035878	nail development
0.66	GO:0051798	positive regulation of hair follicle development
0.65	GO:0002360	T cell lineage commitment
0.64	GO:0043029	T cell homeostasis
0.64	GO:0030858	positive regulation of epithelial cell differentiation
0.63	GO:0030216	keratinocyte differentiation
0.63	GO:0050673	epithelial cell proliferation

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.38	GO:0044212	transcription regulatory region DNA binding
0.37	GO:0003690	double-stranded DNA binding
0.33	GO:0003682	chromatin binding
0.32	GO:0005215	transporter activity

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|O15354|GPR37_HUMAN
Prosaposin receptor GPR37
Search

GPR37

0.78	Prosaposin receptor GPR37

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.63	GO:0045964	positive regulation of dopamine metabolic process
0.62	GO:0031987	locomotion involved in locomotory behavior
0.62	GO:0042416	dopamine biosynthetic process
0.61	GO:1901032	negative regulation of response to reactive oxygen species
0.61	GO:2001039	negative regulation of cellular response to drug
0.61	GO:1903205	regulation of hydrogen peroxide-induced cell death
0.60	GO:1903202	negative regulation of oxidative stress-induced cell death
0.56	GO:0043410	positive regulation of MAPK cascade

0.72	GO:0004930	G-protein coupled receptor activity
0.60	GO:0030544	Hsp70 protein binding
0.56	GO:0031625	ubiquitin protein ligase binding
0.56	GO:0042277	peptide binding
0.55	GO:0001653	peptide receptor activity

0.55	GO:0043235	receptor complex
0.54	GO:0000151	ubiquitin ligase complex
0.52	GO:0005789	endoplasmic reticulum membrane
0.44	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O15355|PPM1G_HUMAN
Protein phosphatase 1G
Search

PPM1G

0.77	Protein phosphatase 1G (Formerly 2C), magnesium-dependent, gamma isoform

0.70	GO:0006470	protein dephosphorylation
0.58	GO:0007050	cell cycle arrest
0.44	GO:0007417	central nervous system development

0.75	GO:0004722	protein serine/threonine phosphatase activity
0.51	GO:0046872	metal ion binding
0.36	GO:0005515	protein binding

0.50	GO:0005654	nucleoplasm
0.34	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|O15357|SHIP2_HUMAN
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Search

INPPL1

0.96	Inositol polyphosphate phosphatase like 1

0.81	GO:0046856	phosphatidylinositol dephosphorylation
0.60	GO:0001958	endochondral ossification
0.58	GO:0097178	ruffle assembly
0.56	GO:0032868	response to insulin
0.54	GO:0008285	negative regulation of cell proliferation
0.53	GO:0009791	post-embryonic development
0.53	GO:0006661	phosphatidylinositol biosynthetic process
0.53	GO:0007015	actin filament organization
0.51	GO:0006897	endocytosis
0.50	GO:0006006	glucose metabolic process

0.60	GO:0042169	SH2 domain binding
0.51	GO:0016787	hydrolase activity
0.39	GO:0017124	SH3 domain binding
0.38	GO:0003779	actin binding
0.36	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding

0.51	GO:0005794	Golgi apparatus
0.50	GO:0005829	cytosol
0.43	GO:0005886	plasma membrane
0.40	GO:0030175	filopodium
0.40	GO:0030027	lamellipodium
0.38	GO:0005856	cytoskeleton

0.51

GO:0016787

sp|O15360|FANCA_HUMAN
Fanconi anemia group A protein
Search

FANCA

0.94	Fanconi anemia complementation group A

0.86	GO:2000348	regulation of CD40 signaling pathway
0.86	GO:0045589	regulation of regulatory T cell differentiation
0.84	GO:0007140	male meiotic nuclear division
0.84	GO:0008584	male gonad development
0.84	GO:0008585	female gonad development
0.80	GO:0050727	regulation of inflammatory response
0.79	GO:0051090	regulation of DNA binding transcription factor activity
0.75	GO:0042127	regulation of cell proliferation
0.43	GO:0036297	interstrand cross-link repair
0.40	GO:0006461	protein complex assembly

0.38

GO:0005515

protein binding

0.85	GO:0043240	Fanconi anaemia nuclear complex
0.36	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O15370|SOX12_HUMAN
Transcription factor SOX-12
Search

SOX12

0.91	SRY-box containing protein 4

0.64	GO:0045944	positive regulation of transcription by RNA polymerase II
0.63	GO:0006366	transcription by RNA polymerase II
0.62	GO:0045165	cell fate commitment
0.60	GO:0021510	spinal cord development
0.52	GO:0003357	noradrenergic neuron differentiation
0.51	GO:0016331	morphogenesis of embryonic epithelium
0.51	GO:0014009	glial cell proliferation
0.51	GO:0072395	signal transduction involved in cell cycle checkpoint
0.51	GO:0003211	cardiac ventricle formation
0.51	GO:0060174	limb bud formation

0.71	GO:0001105	RNA polymerase II transcription coactivator activity
0.59	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.57	GO:0000976	transcription regulatory region sequence-specific DNA binding
0.50	GO:0001047	core promoter binding
0.45	GO:0035326	enhancer binding
0.43	GO:0001012	RNA polymerase II regulatory region DNA binding
0.41	GO:0046982	protein heterodimerization activity
0.40	GO:0008135	translation factor activity, RNA binding
0.34	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

0.61	GO:0005634	nucleus
0.49	GO:0070013	intracellular organelle lumen
0.48	GO:0032993	protein-DNA complex
0.44	GO:0044446	intracellular organelle part
0.42	GO:0005667	transcription factor complex
0.38	GO:0005739	mitochondrion

sp|O15371|EIF3D_HUMAN
Eukaryotic translation initiation factor 3 subunit D
Search

EIF3D

0.73	Eukaryotic translation initiation factor 3 subunit D

0.80	GO:0002191	cap-dependent translational initiation
0.72	GO:0001731	formation of translation preinitiation complex
0.71	GO:0006446	regulation of translational initiation
0.59	GO:0075525	viral translational termination-reinitiation
0.58	GO:1902416	positive regulation of mRNA binding
0.58	GO:0075522	IRES-dependent viral translational initiation
0.57	GO:0001732	formation of cytoplasmic translation initiation complex
0.52	GO:0045727	positive regulation of translation
0.34	GO:0043044	ATP-dependent chromatin remodeling
0.34	GO:0006414	translational elongation

0.81	GO:0098808	mRNA cap binding
0.72	GO:0003743	translation initiation factor activity
0.34	GO:0042393	histone binding
0.34	GO:0003746	translation elongation factor activity
0.33	GO:0008270	zinc ion binding
0.33	GO:0003700	DNA binding transcription factor activity
0.33	GO:0016887	ATPase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0008144	drug binding

0.77	GO:0005852	eukaryotic translation initiation factor 3 complex
0.71	GO:0016282	eukaryotic 43S preinitiation complex
0.71	GO:0033290	eukaryotic 48S preinitiation complex
0.34	GO:0016514	SWI/SNF complex
0.33	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.33

GO:0016887

sp|O15372|EIF3H_HUMAN
Eukaryotic translation initiation factor 3 subunit H
Search

EIF3H

0.71	Eukaryotic translation initiation factor 3 subunit H

0.71	GO:0006413	translational initiation
0.68	GO:0002181	cytoplasmic translation
0.64	GO:0022618	ribonucleoprotein complex assembly
0.41	GO:0048882	lateral line development
0.40	GO:0007420	brain development
0.40	GO:0072359	circulatory system development
0.39	GO:0006417	regulation of translation

0.72	GO:0003743	translation initiation factor activity
0.34	GO:0005515	protein binding

0.78	GO:0005852	eukaryotic translation initiation factor 3 complex
0.69	GO:0016282	eukaryotic 43S preinitiation complex
0.69	GO:0033290	eukaryotic 48S preinitiation complex
0.36	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O15374|MOT5_HUMAN
Monocarboxylate transporter 5
Search

SLC16A4

0.96	LOW QUALITY PROTEIN: monocarboxylate transporter 5

0.54	GO:0055085	transmembrane transport
0.47	GO:0015718	monocarboxylic acid transport
0.38	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.36	GO:0019079	viral genome replication
0.33	GO:0043043	peptide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process
0.32	GO:0010467	gene expression
0.32	GO:0009059	macromolecule biosynthetic process

0.48	GO:0008028	monocarboxylic acid transmembrane transporter activity
0.37	GO:0015293	symporter activity
0.33	GO:0003735	structural constituent of ribosome

0.44	GO:0005887	integral component of plasma membrane
0.38	GO:0071986	Ragulator complex
0.33	GO:0005840	ribosome

sp|O15375|MOT6_HUMAN
Monocarboxylate transporter 6
Search

SLC16A5

0.94	Monocarboxylate transporter 6

0.63	GO:0015718	monocarboxylic acid transport
0.55	GO:0055085	transmembrane transport
0.34	GO:0051260	protein homooligomerization
0.34	GO:0015850	organic hydroxy compound transport

0.64	GO:0008028	monocarboxylic acid transmembrane transporter activity
0.37	GO:0015293	symporter activity
0.35	GO:0008270	zinc ion binding
0.34	GO:0005230	extracellular ligand-gated ion channel activity
0.34	GO:1901618	organic hydroxy compound transmembrane transporter activity

0.36	GO:0005887	integral component of plasma membrane
0.32	GO:0005622	intracellular

sp|O15379|HDAC3_HUMAN
Histone deacetylase 3
Search

HDAC3

0.51	Histone deacetylase

0.80	GO:0016575	histone deacetylation
0.60	GO:1903507	negative regulation of nucleic acid-templated transcription
0.58	GO:0071498	cellular response to fluid shear stress
0.57	GO:0042993	positive regulation of transcription factor import into nucleus
0.57	GO:0046329	negative regulation of JNK cascade
0.54	GO:0051225	spindle assembly
0.54	GO:0032008	positive regulation of TOR signaling
0.53	GO:0031647	regulation of protein stability
0.53	GO:0006351	transcription, DNA-templated
0.52	GO:0001934	positive regulation of protein phosphorylation

0.81	GO:0004407	histone deacetylase activity
0.70	GO:0034979	NAD-dependent protein deacetylase activity
0.67	GO:0003714	transcription corepressor activity
0.57	GO:0051059	NF-kappaB binding
0.56	GO:0042826	histone deacetylase binding
0.54	GO:0030332	cyclin binding
0.53	GO:0003682	chromatin binding
0.52	GO:0046872	metal ion binding
0.35	GO:0070491	repressing transcription factor binding
0.34	GO:0051020	GTPase binding

0.56	GO:0005634	nucleus
0.55	GO:0017053	transcriptional repressor complex
0.54	GO:0005876	spindle microtubule
0.49	GO:0005794	Golgi apparatus
0.48	GO:0005829	cytosol
0.48	GO:0070013	intracellular organelle lumen
0.42	GO:0005886	plasma membrane
0.35	GO:1902494	catalytic complex
0.34	GO:0000785	chromatin
0.30	GO:0016021	integral component of membrane

0.81

EC:3.5.1.98

GO:0004407

sp|O15381|NVL_HUMAN
Nuclear valosin-containing protein-like
Search

NVL

0.88	Nuclear valosin-containing protein-like

0.59	GO:0051973	positive regulation of telomerase activity
0.49	GO:0042254	ribosome biogenesis

0.63	GO:1990275	preribosome binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0003723	RNA binding
0.34	GO:0005515	protein binding

0.59	GO:0005697	telomerase holoenzyme complex
0.52	GO:0005730	nucleolus
0.50	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O15382|BCAT2_HUMAN
Branched-chain-amino-acid aminotransferase, mitochondrial
Search

BCAT2

0.49	Branched-chain-amino-acid aminotransferase

0.70	GO:0009081	branched-chain amino acid metabolic process
0.61	GO:0008652	cellular amino acid biosynthetic process
0.51	GO:1990830	cellular response to leukemia inhibitory factor
0.48	GO:0010817	regulation of hormone levels
0.46	GO:0009063	cellular amino acid catabolic process
0.45	GO:1901605	alpha-amino acid metabolic process
0.35	GO:0007595	lactation
0.34	GO:0055114	oxidation-reduction process
0.33	GO:0016192	vesicle-mediated transport
0.33	GO:0043043	peptide biosynthetic process

0.78	GO:0004084	branched-chain-amino-acid transaminase activity
0.34	GO:0016491	oxidoreductase activity
0.34	GO:0042802	identical protein binding
0.33	GO:0019843	rRNA binding
0.33	GO:0003735	structural constituent of ribosome

0.44	GO:0005739	mitochondrion
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0005829	cytosol
0.33	GO:0005634	nucleus
0.33	GO:0044446	intracellular organelle part
0.33	GO:0005840	ribosome
0.30	GO:0016020	membrane

0.78

EC:2.6.1.42

GO:0004084

sp|O15389|SIGL5_HUMAN
Sialic acid-binding Ig-like lectin 5
Search

0.89	Sialic acid binding Ig like lectin 14

0.42	GO:0043312	neutrophil degranulation
0.39	GO:0007155	cell adhesion
0.37	GO:0106015	negative regulation of inflammatory response to wounding
0.36	GO:0045087	innate immune response
0.34	GO:0002244	hematopoietic progenitor cell differentiation
0.33	GO:0007165	signal transduction

0.51	GO:0030246	carbohydrate binding
0.37	GO:0005515	protein binding
0.34	GO:0004888	transmembrane signaling receptor activity

0.43	GO:0101003	ficolin-1-rich granule membrane
0.42	GO:0070821	tertiary granule membrane
0.36	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O15391|TYY2_HUMAN
Transcription factor YY2
Search

0.48	Transcriptional repressor

0.47	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II
0.47	GO:0032688	negative regulation of interferon-beta production
0.47	GO:0010225	response to UV-C
0.45	GO:0034644	cellular response to UV
0.45	GO:0048593	camera-type eye morphogenesis
0.45	GO:0010628	positive regulation of gene expression
0.44	GO:0009952	anterior/posterior pattern specification
0.44	GO:0007283	spermatogenesis
0.43	GO:0000724	double-strand break repair via homologous recombination
0.42	GO:0006403	RNA localization

0.51	GO:0003676	nucleic acid binding
0.45	GO:0046332	SMAD binding
0.45	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.38	GO:0042826	histone deacetylase binding
0.36	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.36	GO:0046872	metal ion binding
0.35	GO:0003682	chromatin binding
0.35	GO:0003714	transcription corepressor activity
0.34	GO:0003713	transcription coactivator activity

0.45	GO:0031519	PcG protein complex
0.44	GO:0031011	Ino80 complex
0.43	GO:0005667	transcription factor complex
0.38	GO:0016363	nuclear matrix
0.35	GO:0005704	polytene chromosome band
0.35	GO:0005654	nucleoplasm
0.35	GO:0005703	polytene chromosome puff
0.33	GO:0005737	cytoplasm

sp|O15392|BIRC5_HUMAN
Baculoviral IAP repeat-containing protein 5
Search

BIRC5

0.94	Baculoviral IAP repeat-containing protein 5

0.76	GO:0043066	negative regulation of apoptotic process
0.74	GO:0043523	regulation of neuron apoptotic process
0.73	GO:0061469	regulation of type B pancreatic cell proliferation
0.70	GO:0000226	microtubule cytoskeleton organization
0.70	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
0.68	GO:0007346	regulation of mitotic cell cycle
0.68	GO:1901215	negative regulation of neuron death
0.67	GO:0097340	inhibition of cysteine-type endopeptidase activity
0.63	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.62	GO:0140014	mitotic nuclear division

0.64	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.56	GO:0004842	ubiquitin-protein transferase activity
0.55	GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process
0.50	GO:0042803	protein homodimerization activity
0.50	GO:0008017	microtubule binding
0.46	GO:0008536	Ran GTPase binding
0.45	GO:0008270	zinc ion binding
0.43	GO:0046965	retinoid X receptor binding
0.42	GO:0051087	chaperone binding
0.42	GO:0046982	protein heterodimerization activity

0.59	GO:0032133	chromosome passenger complex
0.59	GO:0030496	midbody
0.56	GO:0031021	interphase microtubule organizing center
0.56	GO:0000777	condensed chromosome kinetochore
0.55	GO:0005819	spindle
0.54	GO:0005881	cytoplasmic microtubule
0.53	GO:0005814	centriole
0.51	GO:0005634	nucleus
0.47	GO:0005829	cytosol
0.40	GO:0070013	intracellular organelle lumen

0.34	EC:3	GO:0016787
0.56	KEGG:R03876	GO:0004842

sp|O15393|TMPS2_HUMAN
Transmembrane protease serine 2
Search

TMPRSS2

0.97	Transmembrane protease serine 2

0.69	GO:0006898	receptor-mediated endocytosis
0.61	GO:0006508	proteolysis
0.58	GO:0046598	positive regulation of viral entry into host cell
0.49	GO:0051604	protein maturation
0.36	GO:0007596	blood coagulation
0.35	GO:0006883	cellular sodium ion homeostasis
0.35	GO:0007605	sensory perception of sound
0.33	GO:0065009	regulation of molecular function
0.33	GO:1900047	negative regulation of hemostasis
0.33	GO:0050819	negative regulation of coagulation

0.78	GO:0005044	scavenger receptor activity
0.69	GO:0004252	serine-type endopeptidase activity
0.35	GO:0017080	sodium channel regulator activity
0.35	GO:0005509	calcium ion binding
0.34	GO:0005515	protein binding
0.33	GO:0003924	GTPase activity
0.33	GO:0032550	purine ribonucleoside binding
0.33	GO:0019001	guanyl nucleotide binding
0.32	GO:0032555	purine ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.42	GO:0005886	plasma membrane
0.40	GO:0070062	extracellular exosome
0.34	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0043025	neuronal cell body
0.30	GO:0016021	integral component of membrane

0.69

GO:0004252

sp|O15394|NCAM2_HUMAN
Neural cell adhesion molecule 2
Search

NCAM2

0.95	Neural cell adhesion molecule 2

0.71	GO:0007155	cell adhesion
0.43	GO:0007413	axonal fasciculation
0.41	GO:0007608	sensory perception of smell
0.34	GO:0001666	response to hypoxia

0.53

GO:0042802

identical protein binding

0.54	GO:0016604	nuclear body
0.53	GO:0030424	axon
0.43	GO:0005886	plasma membrane
0.35	GO:0031225	anchored component of membrane
0.30	GO:0016021	integral component of membrane

sp|O15397|IPO8_HUMAN
Importin-8
Search

IPO8

0.96	Putative nuclear transport receptor ranbp7/ranbp8 importin beta superfamily

0.69	GO:0006886	intracellular protein transport
0.50	GO:0006606	protein import into nucleus
0.42	GO:0045087	innate immune response
0.41	GO:0007165	signal transduction
0.35	GO:0060964	regulation of gene silencing by miRNA
0.34	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
0.33	GO:0016032	viral process
0.32	GO:0055085	transmembrane transport

0.78	GO:0008536	Ran GTPase binding
0.44	GO:0008565	protein transporter activity
0.44	GO:0046332	SMAD binding
0.42	GO:0042393	histone binding
0.34	GO:0030695	GTPase regulator activity
0.33	GO:0042626	ATPase activity, coupled to transmembrane movement of substances

0.56	GO:0005634	nucleus
0.45	GO:0005829	cytosol
0.43	GO:0012505	endomembrane system
0.41	GO:0031967	organelle envelope
0.40	GO:0031974	membrane-enclosed lumen
0.33	GO:0005887	integral component of plasma membrane
0.32	GO:0043234	protein complex

sp|O15399|NMDE4_HUMAN
Glutamate receptor ionotropic, NMDA 2D
Search

0.94	NMDA ionotropic glutamate receptor epsilon 4 subunit type 1

0.77	GO:0060079	excitatory postsynaptic potential
0.75	GO:0035235	ionotropic glutamate receptor signaling pathway
0.60	GO:0050905	neuromuscular process
0.60	GO:0097553	calcium ion transmembrane import into cytosol
0.60	GO:0019722	calcium-mediated signaling
0.56	GO:0051930	regulation of sensory perception of pain
0.53	GO:0008344	adult locomotory behavior
0.52	GO:0033058	directional locomotion
0.49	GO:0042177	negative regulation of protein catabolic process
0.47	GO:0009611	response to wounding

0.79	GO:0005234	extracellularly glutamate-gated ion channel activity
0.75	GO:0004970	ionotropic glutamate receptor activity
0.60	GO:0099604	ligand-gated calcium channel activity
0.56	GO:0022843	voltage-gated cation channel activity
0.38	GO:0016595	glutamate binding
0.37	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.37	GO:0042165	neurotransmitter binding

0.75	GO:0098794	postsynapse
0.74	GO:0097060	synaptic membrane
0.70	GO:0030054	cell junction
0.63	GO:0017146	NMDA selective glutamate receptor complex
0.49	GO:0032279	asymmetric synapse
0.46	GO:0097458	neuron part
0.38	GO:0005622	intracellular
0.38	GO:0043226	organelle

sp|O15400|STX7_HUMAN
Syntaxin-7
Search

STX7

0.93	Syntaxin 7 (Predicted)

0.69	GO:0016192	vesicle-mediated transport
0.68	GO:0006886	intracellular protein transport
0.68	GO:0061025	membrane fusion
0.63	GO:1902685	positive regulation of receptor localization to synapse
0.61	GO:0001916	positive regulation of T cell mediated cytotoxicity
0.58	GO:1903076	regulation of protein localization to plasma membrane
0.55	GO:0051640	organelle localization
0.51	GO:0070925	organelle assembly
0.48	GO:0065009	regulation of molecular function
0.48	GO:0048284	organelle fusion

0.80	GO:0005484	SNAP receptor activity
0.61	GO:0019869	chloride channel inhibitor activity
0.58	GO:0000149	SNARE binding
0.35	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
0.34	GO:0032403	protein complex binding
0.34	GO:0005507	copper ion binding

0.60	GO:0070820	tertiary granule
0.60	GO:0005766	primary lysosome
0.59	GO:0001772	immunological synapse
0.57	GO:0055037	recycling endosome
0.56	GO:0030139	endocytic vesicle
0.56	GO:0005769	early endosome
0.56	GO:0005770	late endosome
0.55	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0031201	SNARE complex
0.39	GO:0010008	endosome membrane

0.35

EC:1.14.17

GO:0016715

sp|O15403|MOT7_HUMAN
Monocarboxylate transporter 7
Search

SLC16A6

0.91	Monocarboxylate transporter 7

0.55	GO:0055085	transmembrane transport
0.39	GO:0015718	monocarboxylic acid transport

0.39	GO:0008028	monocarboxylic acid transmembrane transporter activity
0.39	GO:0015293	symporter activity

0.38

GO:0005887

integral component of plasma membrane

sp|O15405|TOX3_HUMAN
TOX high mobility group box family member 3
Search

TOX3

0.96	TOX high mobility group box family member 3

0.55	GO:0043524	negative regulation of neuron apoptotic process
0.50	GO:0045893	positive regulation of transcription, DNA-templated
0.38	GO:0006915	apoptotic process
0.35	GO:0019722	calcium-mediated signaling
0.35	GO:0006351	transcription, DNA-templated

0.59	GO:0034056	estrogen response element binding
0.55	GO:0051219	phosphoprotein binding
0.52	GO:0003682	chromatin binding
0.51	GO:0042803	protein homodimerization activity

0.61	GO:0005634	nucleus
0.52	GO:0072357	PTW/PP1 phosphatase complex
0.43	GO:0000781	chromosome, telomeric region
0.41	GO:0000785	chromatin
0.40	GO:0043233	organelle lumen

sp|O15409|FOXP2_HUMAN
Forkhead box protein P2
Search

FOXP2

0.94	Forkhead box transcription factor

0.62	GO:0021758	putamen development
0.62	GO:0021757	caudate nucleus development
0.57	GO:0098596	imitative learning
0.57	GO:0098598	learned vocalization behavior or vocal learning
0.56	GO:0031223	auditory behavior
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis
0.56	GO:0010468	regulation of gene expression
0.55	GO:0060013	righting reflex

0.64	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.52	GO:0042803	protein homodimerization activity
0.50	GO:0044212	transcription regulatory region DNA binding
0.49	GO:0046982	protein heterodimerization activity
0.48	GO:0003690	double-stranded DNA binding
0.39	GO:0050681	androgen receptor binding
0.37	GO:0046872	metal ion binding

0.61	GO:0005634	nucleus
0.37	GO:0044297	cell body
0.30	GO:0031224	intrinsic component of membrane

sp|O15417|TNC18_HUMAN
Trinucleotide repeat-containing gene 18 protein
Search

TNRC18

0.89	Trinucleotide repeat containing 18

0.60	GO:0031507	heterochromatin assembly
0.56	GO:0006342	chromatin silencing

0.77	GO:0003682	chromatin binding
0.54	GO:0000976	transcription regulatory region sequence-specific DNA binding

0.63	GO:0031965	nuclear membrane
0.60	GO:0005677	chromatin silencing complex
0.56	GO:0005829	cytosol
0.51	GO:0000785	chromatin
0.50	GO:0005739	mitochondrion

sp|O15427|MOT4_HUMAN
Monocarboxylate transporter 4
Search

SLC16A3

0.95	Monocarboxylic acid transporter 4

0.81	GO:0035873	lactate transmembrane transport
0.35	GO:0050900	leukocyte migration
0.34	GO:0006090	pyruvate metabolic process

0.81	GO:0015129	lactate transmembrane transporter activity
0.37	GO:0015293	symporter activity
0.34	GO:0003723	RNA binding
0.33	GO:0005515	protein binding

0.67	GO:0005887	integral component of plasma membrane
0.55	GO:0031965	nuclear membrane

sp|O15428|PINL_HUMAN
Putative PIN1-like protein
Search

0.65	GO:0000413	protein peptidyl-prolyl isomerization
0.52	GO:0016567	protein ubiquitination
0.51	GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation
0.51	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.51	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.51	GO:0032091	negative regulation of protein binding
0.51	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.51	GO:0042177	negative regulation of protein catabolic process
0.50	GO:0006511	ubiquitin-dependent protein catabolic process
0.50	GO:0045944	positive regulation of transcription by RNA polymerase II

0.66	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.54	GO:0050816	phosphothreonine residue binding
0.53	GO:0031434	mitogen-activated protein kinase kinase binding
0.53	GO:0032794	GTPase activating protein binding
0.53	GO:0050815	phosphoserine residue binding
0.52	GO:0061630	ubiquitin protein ligase activity
0.50	GO:0008013	beta-catenin binding
0.44	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.43	GO:0001085	RNA polymerase II transcription factor binding
0.42	GO:0016874	ligase activity

0.50	GO:0030496	midbody
0.46	GO:0005634	nucleus
0.44	GO:0070013	intracellular organelle lumen
0.41	GO:0044446	intracellular organelle part
0.39	GO:0005576	extracellular region
0.37	GO:0005737	cytoplasm
0.35	GO:0043005	neuron projection
0.34	GO:0031982	vesicle
0.33	GO:0000151	ubiquitin ligase complex
0.30	GO:0016020	membrane

0.66

GO:0003755

sp|O15431|COPT1_HUMAN
High affinity copper uptake protein 1
Search

SLC31A1

0.91	High affinity copper transporter

0.81	GO:0035434	copper ion transmembrane transport
0.54	GO:0015677	copper ion import
0.51	GO:0006878	cellular copper ion homeostasis
0.44	GO:0042539	hypotonic salinity response
0.44	GO:0071391	cellular response to estrogen stimulus
0.42	GO:0046688	response to copper ion
0.40	GO:0072719	cellular response to cisplatin
0.39	GO:0099587	inorganic ion import across plasma membrane
0.37	GO:0006855	drug transmembrane transport
0.33	GO:0015992	proton transport

0.82	GO:0005375	copper ion transmembrane transporter activity
0.48	GO:0042802	identical protein binding
0.33	GO:0042626	ATPase activity, coupled to transmembrane movement of substances

0.52	GO:0055037	recycling endosome
0.51	GO:0005770	late endosome
0.38	GO:0043025	neuronal cell body
0.35	GO:0005886	plasma membrane
0.34	GO:0005774	vacuolar membrane
0.33	GO:0033176	proton-transporting V-type ATPase complex
0.32	GO:0000324	fungal-type vacuole
0.30	GO:0016021	integral component of membrane

sp|O15432|COPT2_HUMAN
Probable low affinity copper uptake protein 2
Search

SLC31A2

0.97	Probable low affinity copper uptake protein 2

0.81	GO:0035434	copper ion transmembrane transport
0.65	GO:1902311	regulation of copper ion transmembrane transport
0.56	GO:0006878	cellular copper ion homeostasis

0.82	GO:0005375	copper ion transmembrane transporter activity
0.34	GO:0005515	protein binding

0.57	GO:0055037	recycling endosome
0.56	GO:0005770	late endosome
0.35	GO:0005887	integral component of plasma membrane

sp|O15438|MRP3_HUMAN
Canalicular multispecific organic anion transporter 2
Search

ABCC3

0.85	Canalicular multispecific organic anion transporter 2

0.55	GO:0055085	transmembrane transport
0.46	GO:0015722	canalicular bile acid transport
0.42	GO:0042908	xenobiotic transport
0.40	GO:0015893	drug transport
0.38	GO:0032355	response to estradiol
0.37	GO:0032496	response to lipopolysaccharide
0.37	GO:0099133	ATP hydrolysis coupled anion transmembrane transport
0.37	GO:0010243	response to organonitrogen compound

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0042910	xenobiotic transmembrane transporter activity
0.42	GO:0015125	bile acid transmembrane transporter activity
0.40	GO:0015238	drug transmembrane transporter activity

0.43	GO:0016323	basolateral plasma membrane
0.39	GO:0005887	integral component of plasma membrane

sp|O15439|MRP4_HUMAN
Multidrug resistance-associated protein 4
Search

ABCC4

0.87	Multidrug resistance-associated protein 4 splice variant

0.60	GO:0032310	prostaglandin secretion
0.55	GO:0055085	transmembrane transport
0.54	GO:0060271	cilium assembly
0.46	GO:0006821	chloride transport
0.41	GO:1902017	regulation of cilium assembly
0.41	GO:0042221	response to chemical
0.41	GO:0048661	positive regulation of smooth muscle cell proliferation
0.36	GO:0002576	platelet degranulation
0.34	GO:0099133	ATP hydrolysis coupled anion transmembrane transport
0.32	GO:0055114	oxidation-reduction process

0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0005254	chloride channel activity
0.44	GO:0015132	prostaglandin transmembrane transporter activity
0.39	GO:0015562	efflux transmembrane transporter activity
0.38	GO:0015238	drug transmembrane transporter activity
0.36	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity
0.34	GO:0022853	active ion transmembrane transporter activity

0.60	GO:0031088	platelet dense granule membrane
0.55	GO:0016323	basolateral plasma membrane
0.44	GO:0005887	integral component of plasma membrane
0.37	GO:0005929	cilium
0.35	GO:0016324	apical plasma membrane

0.36

EC:1.1.1.141

GO:0016404

sp|O15440|MRP5_HUMAN
Multidrug resistance-associated protein 5
Search

ABCC5

0.95	Multidrug resistance-associated protein 5

0.66	GO:0015711	organic anion transport
0.55	GO:0055085	transmembrane transport
0.41	GO:0030218	erythrocyte differentiation
0.40	GO:0015886	heme transport
0.36	GO:0030213	hyaluronan biosynthetic process
0.35	GO:0032868	response to insulin
0.35	GO:0032496	response to lipopolysaccharide
0.34	GO:0099133	ATP hydrolysis coupled anion transmembrane transport
0.34	GO:0006508	proteolysis

0.69	GO:0008514	organic anion transmembrane transporter activity
0.66	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0008237	metallopeptidase activity
0.34	GO:0008270	zinc ion binding

0.43	GO:0005887	integral component of plasma membrane
0.35	GO:0048471	perinuclear region of cytoplasm

sp|O15442|MPPD1_HUMAN
Metallophosphoesterase domain-containing protein 1
Search

MPPED1

0.94	Metallophosphoesterase domain-containing protein 1

0.34

GO:0007399

nervous system development

0.51	GO:0016787	hydrolase activity
0.33	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.51

GO:0016787

sp|O15444|CCL25_HUMAN
C-C motif chemokine 25
Search

CCL25

0.97	C-C motif chemokine ligand 25

0.82	GO:0060326	cell chemotaxis
0.74	GO:0006955	immune response
0.70	GO:1903237	negative regulation of leukocyte tethering or rolling
0.66	GO:0001954	positive regulation of cell-matrix adhesion
0.58	GO:0071674	mononuclear cell migration
0.58	GO:0072676	lymphocyte migration
0.57	GO:1990266	neutrophil migration
0.57	GO:0007186	G-protein coupled receptor signaling pathway
0.57	GO:0071347	cellular response to interleukin-1
0.56	GO:0071356	cellular response to tumor necrosis factor

0.84	GO:0008009	chemokine activity
0.71	GO:0031735	CCR10 chemokine receptor binding
0.42	GO:0005179	hormone activity

0.66	GO:0005576	extracellular region
0.30	GO:0016020	membrane

sp|O15446|RPA34_HUMAN
DNA-directed RNA polymerase I subunit RPA34
Search

CD3EAP

0.87	CD3e molecule, epsilon associated protein (Fragment)

0.47

GO:0009303

rRNA transcription

0.39

GO:0003723

RNA binding

0.81	GO:0001650	fibrillar center
0.67	GO:0005829	cytosol
0.59	GO:0005739	mitochondrion
0.46	GO:0005736	DNA-directed RNA polymerase I complex

sp|O15453|NBR2_HUMAN
Next to BRCA1 gene 2 protein
Search

0.44	GO:0016192	vesicle-mediated transport
0.43	GO:0015031	protein transport

0.61	GO:0032550	purine ribonucleoside binding
0.61	GO:0019001	guanyl nucleotide binding
0.51	GO:0032553	ribonucleotide binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding

0.45

GO:0005794

Golgi apparatus

sp|O15455|TLR3_HUMAN
Toll-like receptor 3
Search

TLR3

0.87	Toll like receptor 3

0.85	GO:0034138	toll-like receptor 3 signaling pathway
0.85	GO:0002756	MyD88-independent toll-like receptor signaling pathway
0.85	GO:0043330	response to exogenous dsRNA
0.85	GO:0032722	positive regulation of chemokine production
0.83	GO:0050729	positive regulation of inflammatory response
0.78	GO:0045087	innate immune response
0.77	GO:0051607	defense response to virus
0.55	GO:0034346	positive regulation of type III interferon production
0.55	GO:0045356	positive regulation of interferon-alpha biosynthetic process
0.54	GO:0002730	regulation of dendritic cell cytokine production

0.76	GO:0003725	double-stranded RNA binding
0.70	GO:0004888	transmembrane signaling receptor activity
0.47	GO:0042802	identical protein binding

0.39	GO:0005887	integral component of plasma membrane
0.38	GO:0005769	early endosome
0.38	GO:0010008	endosome membrane
0.37	GO:0005789	endoplasmic reticulum membrane
0.36	GO:0036019	endolysosome
0.36	GO:0009986	cell surface
0.35	GO:0005765	lysosomal membrane
0.34	GO:0000139	Golgi membrane

sp|O15457|MSH4_HUMAN
MutS protein homolog 4
Search

MSH4

0.95	MutS homolog 4 variant alpha

0.73	GO:0006298	mismatch repair
0.57	GO:0007129	synapsis
0.57	GO:0001541	ovarian follicle development
0.54	GO:0007292	female gamete generation
0.54	GO:0007283	spermatogenesis
0.46	GO:0007131	reciprocal meiotic recombination
0.41	GO:0022607	cellular component assembly

0.74	GO:0030983	mismatched DNA binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0003684	damaged DNA binding
0.42	GO:0008094	DNA-dependent ATPase activity
0.34	GO:0005515	protein binding

0.60	GO:0005713	recombination nodule
0.57	GO:0000795	synaptonemal complex
0.46	GO:0032300	mismatch repair complex
0.35	GO:0005654	nucleoplasm
0.30	GO:0016020	membrane

sp|O15460|P4HA2_HUMAN
Prolyl 4-hydroxylase subunit alpha-2
Search

P4HA2

0.87	Prolyl 4-hydroxylase subunit alpha-2

0.80	GO:0019511	peptidyl-proline hydroxylation
0.51	GO:0055114	oxidation-reduction process
0.37	GO:0019471	4-hydroxyproline metabolic process
0.33	GO:0007017	microtubule-based process
0.33	GO:0006091	generation of precursor metabolites and energy

0.81	GO:0004656	procollagen-proline 4-dioxygenase activity
0.75	GO:0031418	L-ascorbic acid binding
0.71	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
0.60	GO:0005506	iron ion binding
0.34	GO:0005515	protein binding
0.33	GO:0003924	GTPase activity
0.33	GO:0009055	electron transfer activity

0.67	GO:0005783	endoplasmic reticulum
0.48	GO:0005654	nucleoplasm
0.47	GO:0005829	cytosol
0.35	GO:1990204	oxidoreductase complex
0.34	GO:0005581	collagen trimer
0.34	GO:0005874	microtubule

0.81	EC:1.14.11.2	GO:0004656
0.81	KEGG:R03219	GO:0004656

sp|O15466|SIA8E_HUMAN
Alpha-2,8-sialyltransferase 8E
Search

ST8SIA5

0.92	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5

0.83	GO:0097503	sialylation
0.74	GO:0006486	protein glycosylation
0.40	GO:0006688	glycosphingolipid biosynthetic process
0.37	GO:0001573	ganglioside metabolic process
0.37	GO:0046513	ceramide biosynthetic process
0.36	GO:0009311	oligosaccharide metabolic process
0.35	GO:0016051	carbohydrate biosynthetic process
0.33	GO:0098869	cellular oxidant detoxification
0.32	GO:0055114	oxidation-reduction process

0.83	GO:0008373	sialyltransferase activity
0.34	GO:0005515	protein binding
0.33	GO:0004096	catalase activity
0.33	GO:0020037	heme binding

0.70	GO:0005794	Golgi apparatus
0.36	GO:0098588	bounding membrane of organelle
0.36	GO:0031984	organelle subcompartment
0.30	GO:0031224	intrinsic component of membrane

0.83

GO:0008373

sp|O15467|CCL16_HUMAN
C-C motif chemokine 16
Search

CCL16

0.63	C-C motif chemokine

0.82	GO:0060326	cell chemotaxis
0.74	GO:0006955	immune response
0.70	GO:0010469	regulation of receptor activity
0.68	GO:0050918	positive chemotaxis
0.54	GO:0071674	mononuclear cell migration
0.54	GO:0072676	lymphocyte migration
0.53	GO:1990266	neutrophil migration
0.53	GO:0071347	cellular response to interleukin-1
0.52	GO:0071356	cellular response to tumor necrosis factor
0.52	GO:0070374	positive regulation of ERK1 and ERK2 cascade

0.84	GO:0008009	chemokine activity
0.69	GO:0042056	chemoattractant activity
0.54	GO:0048020	CCR chemokine receptor binding

0.68

GO:0005615

extracellular space

sp|O15479|MAGB2_HUMAN
Melanoma-associated antigen B2
Search

0.97	Melanoma-associated antigen B2

0.40

GO:0007186

G-protein coupled receptor signaling pathway

0.47	GO:0005515	protein binding
0.42	GO:0008528	G-protein coupled peptide receptor activity

0.47	GO:0005737	cytoplasm
0.39	GO:0005654	nucleoplasm
0.30	GO:0044425	membrane part

sp|O15480|MAGB3_HUMAN
Melanoma-associated antigen B3
Search

0.86	Melanoma-associated antigen B18

0.41

GO:0005515

protein binding

0.49	GO:0005737	cytoplasm
0.42	GO:0005654	nucleoplasm

sp|O15481|MAGB4_HUMAN
Melanoma-associated antigen B4
Search

0.92	Melanoma-associated antigen B4

0.48

GO:0005515

protein binding

0.48	GO:0005737	cytoplasm
0.40	GO:0005654	nucleoplasm

sp|O15482|TEX28_HUMAN
Testis-specific protein TEX28
Search

TEX28

0.97	Testis expressed 28 (Predicted)

0.30

GO:0044425

membrane part

sp|O15484|CAN5_HUMAN
Calpain-5
Search

CAPN5

0.95

Calpain-5

0.61	GO:0006508	proteolysis
0.36	GO:0032501	multicellular organismal process
0.35	GO:0060014	granulosa cell differentiation
0.35	GO:0006672	ceramide metabolic process
0.35	GO:0007165	signal transduction
0.35	GO:0007548	sex differentiation
0.34	GO:0048511	rhythmic process
0.34	GO:0006486	protein glycosylation
0.33	GO:0051493	regulation of cytoskeleton organization

0.82	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.35	GO:0008378	galactosyltransferase activity
0.34	GO:0004871	signal transducer activity
0.34	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

0.50	GO:0009986	cell surface
0.45	GO:0005622	intracellular
0.36	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.35

GO:0008378

sp|O15488|GLYG2_HUMAN
Glycogenin-2
Search

GYG2

0.89	Glycogenin-2 isoform a

0.36	GO:0005980	glycogen catabolic process
0.36	GO:0005978	glycogen biosynthetic process

0.65

GO:0016757

transferase activity, transferring glycosyl groups

0.38	GO:0043202	lysosomal lumen
0.35	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.65

GO:0016757

sp|O15492|RGS16_HUMAN
Regulator of G-protein signaling 16
Search

RGS16

0.96	regulator of G-protein signaling 8

0.72	GO:0043547	positive regulation of GTPase activity
0.67	GO:0007186	G-protein coupled receptor signaling pathway
0.42	GO:0009968	negative regulation of signal transduction
0.42	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.39	GO:0095500	acetylcholine receptor signaling pathway
0.36	GO:0007601	visual perception

0.72	GO:0005096	GTPase activator activity
0.37	GO:0005515	protein binding

0.43	GO:0005737	cytoplasm
0.43	GO:0005886	plasma membrane
0.39	GO:0043204	perikaryon
0.39	GO:0030425	dendrite
0.38	GO:0098562	cytoplasmic side of membrane
0.38	GO:0019898	extrinsic component of membrane
0.36	GO:0005634	nucleus
0.36	GO:0045121	membrane raft
0.33	GO:0031974	membrane-enclosed lumen
0.32	GO:0044446	intracellular organelle part

sp|O15496|PA2GX_HUMAN
Group 10 secretory phospholipase A2
Search

PLA2G10

0.66	Group 10 secretory phospholipase A2

0.82	GO:0050482	arachidonic acid secretion
0.72	GO:0016042	lipid catabolic process
0.67	GO:0006644	phospholipid metabolic process
0.61	GO:0032305	positive regulation of icosanoid secretion
0.59	GO:0032306	regulation of prostaglandin secretion
0.58	GO:0010884	positive regulation of lipid storage
0.58	GO:0090370	negative regulation of cholesterol efflux
0.58	GO:0090237	regulation of arachidonic acid secretion
0.57	GO:0051977	lysophospholipid transport
0.57	GO:0043030	regulation of macrophage activation

0.85	GO:0102568	phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
0.85	GO:0102567	phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
0.82	GO:0004623	phospholipase A2 activity
0.70	GO:0005509	calcium ion binding
0.34	GO:0043395	heparan sulfate proteoglycan binding
0.34	GO:0005102	receptor binding
0.34	GO:0008201	heparin binding

0.66	GO:0005576	extracellular region
0.35	GO:0009986	cell surface
0.34	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.82

EC:3.1.1.4

GO:0004623

sp|O15498|YKT6_HUMAN
Synaptobrevin homolog YKT6
Search

YKT6

0.91	Synaptobrevin like protein YKT6

0.67	GO:0016192	vesicle-mediated transport
0.51	GO:0051650	establishment of vesicle localization
0.51	GO:0016482	cytosolic transport
0.51	GO:0140056	organelle localization by membrane tethering
0.50	GO:0016197	endosomal transport
0.48	GO:0032940	secretion by cell
0.48	GO:0061025	membrane fusion
0.47	GO:0048284	organelle fusion
0.46	GO:0016050	vesicle organization
0.38	GO:0015031	protein transport

0.53	GO:0005484	SNAP receptor activity
0.51	GO:0045296	cadherin binding
0.51	GO:0019706	protein-cysteine S-palmitoyltransferase activity
0.47	GO:0000149	SNARE binding
0.34	GO:0004683	calmodulin-dependent protein kinase activity
0.34	GO:0005516	calmodulin binding

0.49	GO:0005768	endosome
0.48	GO:0005794	Golgi apparatus
0.48	GO:0031201	SNARE complex
0.47	GO:0005829	cytosol
0.47	GO:0005783	endoplasmic reticulum
0.46	GO:0005887	integral component of plasma membrane
0.43	GO:0005739	mitochondrion
0.41	GO:0097441	basal dendrite
0.41	GO:0030659	cytoplasmic vesicle membrane
0.40	GO:0097440	apical dendrite

0.51

EC:2.3.1.225

GO:0019706

sp|O15499|GSC2_HUMAN
Homeobox protein goosecoid-2
Search

GSC2

0.97	Homeodomain protein goosecoid

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.36	GO:0048856	anatomical structure development
0.33	GO:0032501	multicellular organismal process
0.33	GO:0048033	heme o metabolic process
0.33	GO:0006783	heme biosynthetic process
0.33	GO:0051253	negative regulation of RNA metabolic process
0.33	GO:0010558	negative regulation of macromolecule biosynthetic process
0.33	GO:0031327	negative regulation of cellular biosynthetic process

0.64	GO:0043565	sequence-specific DNA binding
0.44	GO:0003700	DNA binding transcription factor activity
0.34	GO:0005515	protein binding
0.33	GO:0008495	protoheme IX farnesyltransferase activity
0.33	GO:0004000	adenosine deaminase activity
0.33	GO:0008375	acetylglucosaminyltransferase activity

0.61	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.33

EC:2.5.1

GO:0008495

sp|O15503|INSI1_HUMAN
Insulin-induced gene 1 protein
Search

INSIG1

0.94	Insulin-induced gene protein (Fragment)

0.83	GO:0008203	cholesterol metabolic process
0.62	GO:0060363	cranial suture morphogenesis
0.61	GO:0036316	SREBP-SCAP complex retention in endoplasmic reticulum
0.61	GO:1901303	negative regulation of cargo loading into COPII-coated vesicle
0.61	GO:0042474	middle ear morphogenesis
0.60	GO:0010894	negative regulation of steroid biosynthetic process
0.59	GO:0006991	response to sterol depletion
0.59	GO:0070862	negative regulation of protein exit from endoplasmic reticulum
0.59	GO:0060021	palate development
0.58	GO:0006984	ER-nucleus signaling pathway

0.33

GO:0005515

protein binding

0.65	GO:0005789	endoplasmic reticulum membrane
0.46	GO:0098796	membrane protein complex
0.30	GO:0031224	intrinsic component of membrane

sp|O15504|NUPL2_HUMAN
Nucleoporin-like protein 2
Search

NUPL2

0.89	Nucleoporin like 2

0.68	GO:0006611	protein export from nucleus
0.39	GO:0051028	mRNA transport
0.30	GO:0060966	regulation of gene silencing by RNA
0.30	GO:0044237	cellular metabolic process
0.30	GO:0071427	mRNA-containing ribonucleoprotein complex export from nucleus
0.30	GO:0016032	viral process
0.30	GO:0061024	membrane organization
0.30	GO:0010556	regulation of macromolecule biosynthetic process
0.30	GO:0010256	endomembrane system organization
0.30	GO:0051196	regulation of coenzyme metabolic process

0.69	GO:0005049	nuclear export signal receptor activity
0.53	GO:0046872	metal ion binding
0.30	GO:0005515	protein binding
0.30	GO:1901363	heterocyclic compound binding
0.30	GO:0097159	organic cyclic compound binding

0.58	GO:0005635	nuclear envelope
0.54	GO:0005654	nucleoplasm
0.52	GO:0005829	cytosol
0.36	GO:0031090	organelle membrane
0.36	GO:0043234	protein complex
0.30	GO:0044216	other organism cell
0.30	GO:0018995	host

sp|O15511|ARPC5_HUMAN
Actin-related protein 2/3 complex subunit 5
Search

ARPC5

0.71	Actin-related protein 2/3 complex subunit 5

0.81	GO:0034314	Arp2/3 complex-mediated actin nucleation
0.53	GO:0016477	cell migration
0.40	GO:0021769	orbitofrontal cortex development
0.39	GO:0051639	actin filament network formation
0.39	GO:0030011	maintenance of cell polarity
0.39	GO:0097581	lamellipodium organization
0.39	GO:0061842	microtubule organizing center localization
0.36	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.35	GO:0043312	neutrophil degranulation
0.35	GO:0048013	ephrin receptor signaling pathway

0.54	GO:0051015	actin filament binding
0.50	GO:0005200	structural constituent of cytoskeleton

0.80	GO:0005885	Arp2/3 protein complex
0.53	GO:0030027	lamellipodium
0.38	GO:0030426	growth cone
0.37	GO:0005768	endosome
0.37	GO:0005925	focal adhesion
0.36	GO:0070062	extracellular exosome
0.36	GO:1904813	ficolin-1-rich granule lumen
0.35	GO:0034774	secretory granule lumen
0.35	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O15514|RPB4_HUMAN
DNA-directed RNA polymerase II subunit RPB4
Search

POLR2D

0.91	RNA polymerase II subunit D

0.58	GO:0006351	transcription, DNA-templated
0.53	GO:0031990	mRNA export from nucleus in response to heat stress
0.53	GO:0034402	recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
0.50	GO:0045948	positive regulation of translational initiation
0.50	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
0.35	GO:0035019	somatic stem cell population maintenance
0.35	GO:0060964	regulation of gene silencing by miRNA
0.35	GO:0008543	fibroblast growth factor receptor signaling pathway
0.34	GO:0016073	snRNA metabolic process
0.34	GO:0050434	positive regulation of viral transcription

0.70	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.53	GO:1901265	nucleoside phosphate binding
0.51	GO:0036094	small molecule binding
0.50	GO:0031369	translation initiation factor binding
0.49	GO:0003727	single-stranded RNA binding
0.47	GO:0003697	single-stranded DNA binding
0.33	GO:0008270	zinc ion binding

0.56	GO:0005665	DNA-directed RNA polymerase II, core complex
0.51	GO:0016607	nuclear speck
0.50	GO:0000932	P-body
0.47	GO:0005829	cytosol

0.70

GO:0003899

sp|O15516|CLOCK_HUMAN
Circadian locomoter output cycles protein kaput
Search

CLOCK

0.90	Circadian rhythmicity protein CLOCK

0.65	GO:0032922	circadian regulation of gene expression
0.64	GO:2000074	regulation of type B pancreatic cell development
0.64	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway
0.62	GO:0042634	regulation of hair cycle
0.60	GO:0071479	cellular response to ionizing radiation
0.59	GO:0050729	positive regulation of inflammatory response
0.59	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.59	GO:0050796	regulation of insulin secretion
0.59	GO:0051775	response to redox state
0.58	GO:0000077	DNA damage checkpoint

0.68	GO:0046983	protein dimerization activity
0.62	GO:0070888	E-box binding
0.61	GO:0003700	DNA binding transcription factor activity
0.60	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.59	GO:0001046	core promoter sequence-specific DNA binding
0.59	GO:0031490	chromatin DNA binding
0.57	GO:0004402	histone acetyltransferase activity

0.75	GO:0005667	transcription factor complex
0.63	GO:0033391	chromatoid body
0.61	GO:0005634	nucleus
0.51	GO:0005829	cytosol
0.51	GO:0005694	chromosome
0.50	GO:0043233	organelle lumen
0.45	GO:0044446	intracellular organelle part

0.57

GO:0004402

sp|O15519|CFLAR_HUMAN
CASP8 and FADD-like apoptosis regulator
Search

CFLAR

0.97	CASP8 and FADD like apoptosis regulator

0.73	GO:0042981	regulation of apoptotic process
0.65	GO:0060544	regulation of necroptotic process
0.60	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.60	GO:0006915	apoptotic process
0.60	GO:0043069	negative regulation of programmed cell death
0.58	GO:0006508	proteolysis
0.56	GO:0009968	negative regulation of signal transduction
0.55	GO:0043085	positive regulation of catalytic activity
0.45	GO:0072126	positive regulation of glomerular mesangial cell proliferation
0.44	GO:2000347	positive regulation of hepatocyte proliferation

0.72	GO:0004197	cysteine-type endopeptidase activity
0.62	GO:0002020	protease binding
0.56	GO:0008047	enzyme activator activity
0.44	GO:0005123	death receptor binding
0.40	GO:0032403	protein complex binding
0.37	GO:0061134	peptidase regulator activity
0.37	GO:0046982	protein heterodimerization activity
0.33	GO:0003950	NAD+ ADP-ribosyltransferase activity

0.66	GO:0031264	death-inducing signaling complex
0.65	GO:0097342	ripoptosome
0.42	GO:0098857	membrane microdomain

0.72

EC:3.4.22

GO:0004197

sp|O15520|FGF10_HUMAN
Fibroblast growth factor 10
Search

FGF10

0.62	Fibroblast growth factor

0.83	GO:0008543	fibroblast growth factor receptor signaling pathway
0.75	GO:0010469	regulation of receptor activity
0.64	GO:0050674	urothelial cell proliferation
0.63	GO:0050675	regulation of urothelial cell proliferation
0.63	GO:0070075	tear secretion
0.62	GO:0071338	positive regulation of hair follicle cell proliferation
0.62	GO:0060447	bud outgrowth involved in lung branching
0.62	GO:0061033	secretion by lung epithelial cell involved in lung growth
0.62	GO:0031659	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
0.62	GO:0051549	positive regulation of keratinocyte migration

0.85	GO:0005104	fibroblast growth factor receptor binding
0.78	GO:0008083	growth factor activity
0.61	GO:0042056	chemoattractant activity
0.56	GO:0008201	heparin binding
0.36	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.36	GO:0016303	1-phosphatidylinositol-3-kinase activity
0.35	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.35	GO:0004713	protein tyrosine kinase activity

0.66	GO:0005576	extracellular region
0.55	GO:0009986	cell surface
0.47	GO:0005634	nucleus
0.43	GO:0005886	plasma membrane
0.38	GO:0005794	Golgi apparatus
0.38	GO:0070013	intracellular organelle lumen
0.36	GO:0043232	intracellular non-membrane-bounded organelle
0.36	GO:0044446	intracellular organelle part
0.30	GO:0016021	integral component of membrane

0.36	EC:2.7.1.153	GO:0046934
0.36	KEGG:R04545	GO:0046934

sp|O15522|NKX28_HUMAN
Homeobox protein Nkx-2.8
Search

NKX2-8

0.97	Ventral nervous system defective 1

0.60	GO:0035295	tube development
0.59	GO:0030182	neuron differentiation
0.58	GO:0050680	negative regulation of epithelial cell proliferation
0.57	GO:0045944	positive regulation of transcription by RNA polymerase II
0.57	GO:0048468	cell development
0.57	GO:0060541	respiratory system development
0.57	GO:0048513	animal organ development
0.56	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.54	GO:0120036	plasma membrane bounded cell projection organization
0.54	GO:0006366	transcription by RNA polymerase II

0.64	GO:0043565	sequence-specific DNA binding
0.58	GO:0044212	transcription regulatory region DNA binding
0.57	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.56	GO:0003690	double-stranded DNA binding
0.46	GO:0003713	transcription coactivator activity
0.45	GO:0003682	chromatin binding
0.43	GO:0008134	transcription factor binding
0.35	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
0.33	GO:0005267	potassium channel activity
0.32	GO:0016740	transferase activity

0.61	GO:0005634	nucleus
0.34	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.32

EC:2

GO:0016740

sp|O15523|DDX3Y_HUMAN
ATP-dependent RNA helicase DDX3Y
Search

DDX3X

0.86	DEAD-box helicase 3, Y-linked

0.48	GO:0010501	RNA secondary structure unwinding
0.48	GO:1903608	protein localization to cytoplasmic stress granule
0.48	GO:0071243	cellular response to arsenic-containing substance
0.47	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
0.47	GO:0045070	positive regulation of viral genome replication
0.47	GO:0034063	stress granule assembly
0.47	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
0.46	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway
0.46	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.46	GO:0090263	positive regulation of canonical Wnt signaling pathway

0.67	GO:0004386	helicase activity
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0003676	nucleic acid binding
0.50	GO:0043273	CTPase activity
0.47	GO:0008190	eukaryotic initiation factor 4E binding
0.47	GO:0043024	ribosomal small subunit binding
0.46	GO:0043539	protein serine/threonine kinase activator activity

0.47	GO:0036464	cytoplasmic ribonucleoprotein granule
0.45	GO:0022627	cytosolic small ribosomal subunit
0.44	GO:0005852	eukaryotic translation initiation factor 3 complex
0.42	GO:0005634	nucleus
0.40	GO:0070013	intracellular organelle lumen
0.38	GO:0070062	extracellular exosome
0.37	GO:0005741	mitochondrial outer membrane
0.37	GO:0101002	ficolin-1-rich granule
0.36	GO:0031983	vesicle lumen
0.35	GO:0044433	cytoplasmic vesicle part

sp|O15524|SOCS1_HUMAN
Suppressor of cytokine signaling 1
Search

SOCS1

0.95	Suppressor of cytokine signaling

0.85	GO:0060330	regulation of response to interferon-gamma
0.85	GO:0046426	negative regulation of JAK-STAT cascade
0.72	GO:0001959	regulation of cytokine-mediated signaling pathway
0.67	GO:0016567	protein ubiquitination
0.63	GO:0010533	regulation of activation of Janus kinase activity
0.63	GO:0042509	regulation of tyrosine phosphorylation of STAT protein
0.63	GO:0045591	positive regulation of regulatory T cell differentiation
0.61	GO:0046627	negative regulation of insulin receptor signaling pathway
0.61	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
0.60	GO:0035556	intracellular signal transduction

0.65	GO:0005159	insulin-like growth factor receptor binding
0.59	GO:0019210	kinase inhibitor activity
0.56	GO:0019901	protein kinase binding
0.48	GO:0019887	protein kinase regulator activity
0.46	GO:0008269	JAK pathway signal transduction adaptor activity
0.33	GO:0003677	DNA binding
0.32	GO:0003924	GTPase activity
0.32	GO:0005525	GTP binding

0.56	GO:0036464	cytoplasmic ribonucleoprotein granule
0.51	GO:0005654	nucleoplasm
0.38	GO:0031410	cytoplasmic vesicle
0.36	GO:0005829	cytosol
0.32	GO:0000786	nucleosome

sp|O15525|MAFG_HUMAN
Transcription factor MafG
Search

MAFG

0.94	Transcription factor MafG

0.57	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.50	GO:0045604	regulation of epidermal cell differentiation
0.48	GO:0030534	adult behavior
0.47	GO:0001701	in utero embryonic development
0.46	GO:0042127	regulation of cell proliferation
0.45	GO:0051254	positive regulation of RNA metabolic process
0.45	GO:0010557	positive regulation of macromolecule biosynthetic process

0.74	GO:0046982	protein heterodimerization activity
0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.46	GO:0001067	regulatory region nucleic acid binding

0.61	GO:0005634	nucleus
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0044446	intracellular organelle part

sp|O15527|OGG1_HUMAN
N-glycosylase/DNA lyase
Search

OGG1

0.52	8-oxoguanine DNA glycosylase

0.72	GO:0006284	base-excision repair
0.72	GO:0006289	nucleotide-excision repair
0.64	GO:1901291	negative regulation of double-strand break repair via single-strand annealing
0.61	GO:0033158	regulation of protein import into nucleus, translocation
0.54	GO:0009314	response to radiation
0.51	GO:0006979	response to oxidative stress
0.47	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.44	GO:0051593	response to folic acid
0.44	GO:2001141	regulation of RNA biosynthetic process
0.44	GO:2000112	regulation of cellular macromolecule biosynthetic process

0.78	GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity
0.72	GO:0003684	damaged DNA binding
0.54	GO:0008017	microtubule binding
0.48	GO:0016829	lyase activity
0.34	GO:0004519	endonuclease activity
0.33	GO:0046872	metal ion binding

0.58	GO:0016363	nuclear matrix
0.56	GO:0016607	nuclear speck
0.47	GO:0005739	mitochondrion
0.45	GO:0043234	protein complex
0.32	GO:0000775	chromosome, centromeric region
0.30	GO:0031224	intrinsic component of membrane

0.78

EC:3.2.2.23

GO:0008534

sp|O15528|CP27B_HUMAN
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Search

CYP27B1

0.42	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

0.68	GO:0036378	calcitriol biosynthetic process from calciol
0.66	GO:0070564	positive regulation of vitamin D receptor signaling pathway
0.65	GO:0042369	vitamin D catabolic process
0.64	GO:0010979	regulation of vitamin D 24-hydroxylase activity
0.64	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity
0.64	GO:0070314	G1 to G0 transition
0.63	GO:0045618	positive regulation of keratinocyte differentiation
0.62	GO:0046697	decidualization
0.62	GO:0033280	response to vitamin D
0.61	GO:0030282	bone mineralization

0.69	GO:0004498	calcidiol 1-monooxygenase activity
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding
0.37	GO:0008176	tRNA (guanine-N7-)-methyltransferase activity
0.35	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
0.35	GO:0000049	tRNA binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0043168	anion binding
0.32	GO:0000166	nucleotide binding
0.32	GO:0008144	drug binding

0.47	GO:0005739	mitochondrion
0.36	GO:0031967	organelle envelope
0.36	GO:0031090	organelle membrane
0.35	GO:0098805	whole membrane
0.34	GO:0005634	nucleus
0.34	GO:0019867	outer membrane
0.30	GO:0016021	integral component of membrane

0.69	EC:1.14.13.13	GO:0004498
0.69	KEGG:R03610	GO:0004498

sp|O15529|GPR42_HUMAN
G-protein coupled receptor 42
Search

0.59	G-protein coupled receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.62	GO:0002879	positive regulation of acute inflammatory response to non-antigenic stimulus
0.59	GO:0002385	mucosal immune response
0.59	GO:0002720	positive regulation of cytokine production involved in immune response
0.59	GO:0071398	cellular response to fatty acid
0.58	GO:0032722	positive regulation of chemokine production
0.57	GO:0090276	regulation of peptide hormone secretion
0.56	GO:0003062	regulation of heart rate by chemical signal
0.56	GO:0045760	positive regulation of action potential
0.55	GO:0051050	positive regulation of transport

0.72	GO:0004930	G-protein coupled receptor activity
0.44	GO:0001653	peptide receptor activity
0.38	GO:0008289	lipid binding
0.32	GO:0005515	protein binding
0.32	GO:0008233	peptidase activity

0.39	GO:0005886	plasma membrane
0.35	GO:0042995	cell projection
0.32	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

0.32

GO:0008233

sp|O15530|PDPK1_HUMAN
3-phosphoinositide-dependent protein kinase 1
Search

PDPK1

0.91	Phosphoinositide-dependent protein kinase-1 beta

0.63	GO:0006468	protein phosphorylation
0.56	GO:1905564	positive regulation of vascular endothelial cell proliferation
0.55	GO:0032148	activation of protein kinase B activity
0.54	GO:0071364	cellular response to epidermal growth factor stimulus
0.54	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
0.54	GO:0010518	positive regulation of phospholipase activity
0.54	GO:0043536	positive regulation of blood vessel endothelial cell migration
0.54	GO:1903078	positive regulation of protein localization to plasma membrane
0.53	GO:0007173	epidermal growth factor receptor signaling pathway
0.53	GO:0097191	extrinsic apoptotic signaling pathway

0.64	GO:0004672	protein kinase activity
0.56	GO:0016004	phospholipase activator activity
0.56	GO:0043274	phospholipase binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0032555	purine ribonucleotide binding
0.38	GO:0005158	insulin receptor binding
0.37	GO:0019901	protein kinase binding

0.49	GO:0014069	postsynaptic density
0.46	GO:0042995	cell projection
0.45	GO:0031410	cytoplasmic vesicle
0.41	GO:0005886	plasma membrane
0.38	GO:0043204	perikaryon
0.37	GO:0005925	focal adhesion
0.36	GO:0005829	cytosol
0.35	GO:0005634	nucleus
0.33	GO:0070013	intracellular organelle lumen
0.33	GO:0044446	intracellular organelle part

sp|O15533|TPSN_HUMAN
Tapasin
Search

TAPBP

0.93	TAP binding protein (Tapasin)

0.85

GO:0019885

antigen processing and presentation of endogenous peptide antigen via MHC class I

0.34

GO:0003676

nucleic acid binding

0.30

GO:0044425

membrane part

sp|O15534|PER1_HUMAN
Period circadian protein homolog 1
Search

PER1

0.89	Period circadian protein like protein 1

0.85	GO:0097167	circadian regulation of translation
0.85	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway
0.84	GO:0043153	entrainment of circadian clock by photoperiod
0.83	GO:0042634	regulation of hair cycle
0.81	GO:0032922	circadian regulation of gene expression
0.80	GO:0002028	regulation of sodium ion transport
0.80	GO:0051591	response to cAMP
0.79	GO:0043966	histone H3 acetylation
0.78	GO:0043967	histone H4 acetylation
0.77	GO:0070932	histone H3 deacetylation

0.82	GO:0070888	E-box binding
0.78	GO:0031490	chromatin DNA binding
0.74	GO:0031625	ubiquitin protein ligase binding
0.73	GO:0019900	kinase binding
0.70	GO:0000989	transcription factor activity, transcription factor binding
0.68	GO:0008134	transcription factor binding

0.65	GO:0005654	nucleoplasm
0.64	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O15535|ZSC9_HUMAN
Zinc finger and SCAN domain-containing protein 9
Search

0.92	Zinc finger and SCAN domain-containing protein 9

0.55	GO:2001141	regulation of RNA biosynthetic process
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.54	GO:0010468	regulation of gene expression
0.51	GO:0006351	transcription, DNA-templated
0.40	GO:0015074	DNA integration
0.36	GO:0051254	positive regulation of RNA metabolic process
0.36	GO:0010557	positive regulation of macromolecule biosynthetic process
0.36	GO:0031328	positive regulation of cellular biosynthetic process
0.36	GO:0051253	negative regulation of RNA metabolic process
0.36	GO:0010558	negative regulation of macromolecule biosynthetic process

0.59	GO:0003700	DNA binding transcription factor activity
0.49	GO:0003676	nucleic acid binding
0.48	GO:0046872	metal ion binding
0.36	GO:0005515	protein binding

0.58	GO:0005634	nucleus
0.41	GO:0015630	microtubule cytoskeleton
0.41	GO:0043233	organelle lumen
0.41	GO:0005829	cytosol
0.38	GO:0044446	intracellular organelle part
0.37	GO:0005886	plasma membrane

sp|O15537|XLRS1_HUMAN
Retinoschisin
Search

RS1

0.97	Retinoschisin

0.83	GO:0016062	adaptation of rhodopsin mediated signaling
0.78	GO:0010842	retina layer formation
0.71	GO:0007601	visual perception
0.70	GO:0051260	protein homooligomerization
0.48	GO:0007596	blood coagulation
0.44	GO:0008015	blood circulation
0.41	GO:0007155	cell adhesion
0.37	GO:0032571	response to vitamin K
0.36	GO:0072376	protein activation cascade

0.79	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
0.79	GO:0010314	phosphatidylinositol-5-phosphate binding
0.78	GO:0001786	phosphatidylserine binding
0.78	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.76	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding
0.76	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.74	GO:0070273	phosphatidylinositol-4-phosphate binding
0.74	GO:0032266	phosphatidylinositol-3-phosphate binding
0.63	GO:0070492	oligosaccharide binding
0.47	GO:0005507	copper ion binding

0.69	GO:0019897	extrinsic component of plasma membrane
0.68	GO:0005615	extracellular space
0.46	GO:0031091	platelet alpha granule
0.36	GO:1903561	extracellular vesicle
0.35	GO:0005794	Golgi apparatus
0.35	GO:0005783	endoplasmic reticulum
0.30	GO:0016021	integral component of membrane

sp|O15539|RGS5_HUMAN
Regulator of G-protein signaling 5
Search

RGS5

0.96	Regulator of G-protein signaling 5

0.62	GO:0043547	positive regulation of GTPase activity
0.47	GO:0009968	negative regulation of signal transduction
0.46	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.46	GO:0007186	G-protein coupled receptor signaling pathway
0.37	GO:0095500	acetylcholine receptor signaling pathway

0.62	GO:0005096	GTPase activator activity
0.36	GO:0001965	G-protein alpha-subunit binding

0.64	GO:0005829	cytosol
0.46	GO:0005886	plasma membrane
0.38	GO:0098562	cytoplasmic side of membrane
0.37	GO:0019898	extrinsic component of membrane
0.37	GO:0043204	perikaryon
0.36	GO:0030425	dendrite
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|O15540|FABP7_HUMAN
Fatty acid-binding protein, brain
Search

FABP7

0.81	Fatty acid-binding protein, brain

0.53	GO:0060134	prepulse inhibition
0.52	GO:0021846	cell proliferation in forebrain
0.47	GO:0022008	neurogenesis
0.38	GO:0050673	epithelial cell proliferation
0.36	GO:0001947	heart looping
0.35	GO:0043009	chordate embryonic development
0.35	GO:0019433	triglyceride catabolic process
0.35	GO:0003407	neural retina development
0.34	GO:0008285	negative regulation of cell proliferation

0.72	GO:0008289	lipid binding
0.35	GO:0033293	monocarboxylic acid binding
0.34	GO:0008134	transcription factor binding
0.33	GO:0016787	hydrolase activity

0.50	GO:0043025	neuronal cell body
0.48	GO:0005911	cell-cell junction
0.45	GO:0042995	cell projection
0.40	GO:0071944	cell periphery
0.34	GO:0005829	cytosol
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0016787

sp|O15541|R113A_HUMAN
RING finger protein 113A
Search

RNF113A

0.64	Zinc finger protein 183

0.53	GO:0034247	snoRNA splicing
0.50	GO:0045292	mRNA cis splicing, via spliceosome

0.54	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding
0.33	GO:0016874	ligase activity

0.49

GO:0005684

U2-type spliceosomal complex

0.33

GO:0016874

sp|O15544|GR6_HUMAN
Protein GR6
Search

sp|O15547|P2RX6_HUMAN
P2X purinoceptor 6
Search

P2RX6

0.86	Purinergic receptor P2X 6

0.85	GO:0033198	response to ATP
0.85	GO:0035590	purinergic nucleotide receptor signaling pathway
0.80	GO:0060079	excitatory postsynaptic potential
0.70	GO:0051260	protein homooligomerization
0.61	GO:0098655	cation transmembrane transport

0.85	GO:0004931	extracellularly ATP-gated cation channel activity
0.85	GO:0016502	nucleotide receptor activity
0.84	GO:0035586	purinergic receptor activity
0.67	GO:0042802	identical protein binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.78	GO:0098794	postsynapse
0.67	GO:0030054	cell junction
0.67	GO:0005887	integral component of plasma membrane
0.47	GO:0005737	cytoplasm

sp|O15550|KDM6A_HUMAN
Lysine-specific demethylase 6A
Search

KDM6A

0.92	Ubiquitously transcribed tetratricopeptide repeat protein X-linked transcript variant 4

0.85	GO:0071557	histone H3-K27 demethylation
0.56	GO:0032259	methylation
0.56	GO:0060255	regulation of macromolecule metabolic process
0.47	GO:0032525	somite rostral/caudal axis specification
0.47	GO:0003016	respiratory system process
0.46	GO:0048570	notochord morphogenesis
0.46	GO:0048333	mesodermal cell differentiation
0.45	GO:0001843	neural tube closure
0.45	GO:0035264	multicellular organism growth
0.45	GO:0060070	canonical Wnt signaling pathway

0.85	GO:0071558	histone demethylase activity (H3-K27 specific)
0.57	GO:0008168	methyltransferase activity
0.54	GO:0046872	metal ion binding
0.45	GO:0031490	chromatin DNA binding
0.44	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.42	GO:0042802	identical protein binding
0.35	GO:0051213	dioxygenase activity

0.46	GO:0044666	MLL3/4 complex
0.30	GO:0031224	intrinsic component of membrane

0.57

GO:0008168

sp|O15551|CLD3_HUMAN
Claudin-3
Search

CLDN3

0.69

Claudin c

0.58	GO:0045216	cell-cell junction organization
0.57	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
0.53	GO:0003382	epithelial cell morphogenesis
0.53	GO:0070293	renal absorption
0.53	GO:0051291	protein heterooligomerization
0.52	GO:0061436	establishment of skin barrier
0.52	GO:0034329	cell junction assembly
0.51	GO:0001666	response to hypoxia
0.50	GO:0051260	protein homooligomerization
0.48	GO:1902476	chloride transmembrane transport

0.62	GO:0005198	structural molecule activity
0.51	GO:0104005	hijacked molecular function
0.49	GO:0042802	identical protein binding
0.48	GO:0005254	chloride channel activity
0.35	GO:0004888	transmembrane signaling receptor activity
0.32	GO:0016787	hydrolase activity

0.81	GO:0005923	bicellular tight junction
0.63	GO:0016327	apicolateral plasma membrane
0.55	GO:0016328	lateral plasma membrane
0.44	GO:0005887	integral component of plasma membrane
0.39	GO:0045178	basal part of cell
0.39	GO:0043227	membrane-bounded organelle
0.38	GO:0045177	apical part of cell
0.38	GO:0034707	chloride channel complex
0.38	GO:0043229	intracellular organelle
0.38	GO:0016323	basolateral plasma membrane

0.32

GO:0016787

sp|O15552|FFAR2_HUMAN
Free fatty acid receptor 2
Search

FFAR2

0.97	Free fatty acid receptor 2

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.65	GO:0002879	positive regulation of acute inflammatory response to non-antigenic stimulus
0.62	GO:0002385	mucosal immune response
0.62	GO:0071398	cellular response to fatty acid
0.61	GO:0002720	positive regulation of cytokine production involved in immune response
0.60	GO:0002752	cell surface pattern recognition receptor signaling pathway
0.60	GO:0032722	positive regulation of chemokine production
0.60	GO:0002232	leukocyte chemotaxis involved in inflammatory response
0.59	GO:0090276	regulation of peptide hormone secretion
0.58	GO:2000484	positive regulation of interleukin-8 secretion

0.72	GO:0004930	G-protein coupled receptor activity
0.38	GO:0008289	lipid binding
0.35	GO:0016502	nucleotide receptor activity
0.35	GO:0035586	purinergic receptor activity
0.34	GO:0005515	protein binding

0.42	GO:0005886	plasma membrane
0.38	GO:0042995	cell projection
0.32	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

sp|O15553|MEFV_HUMAN
Pyrin
Search

MEFV

0.91	MEFV, pyrin innate immunity regulator

0.64	GO:0071641	negative regulation of macrophage inflammatory protein 1 alpha production
0.63	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly
0.62	GO:1900016	negative regulation of cytokine production involved in inflammatory response
0.62	GO:0032691	negative regulation of interleukin-1 beta production
0.62	GO:0032695	negative regulation of interleukin-12 production
0.59	GO:0034341	response to interferon-gamma
0.58	GO:2001056	positive regulation of cysteine-type endopeptidase activity
0.56	GO:0006954	inflammatory response
0.56	GO:0010508	positive regulation of autophagy
0.47	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

0.61	GO:0008270	zinc ion binding
0.56	GO:0042802	identical protein binding
0.53	GO:0003779	actin binding
0.37	GO:0016874	ligase activity
0.33	GO:0016740	transferase activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0003676	nucleic acid binding

0.54	GO:0005875	microtubule associated complex
0.47	GO:0005634	nucleus
0.43	GO:0005829	cytosol
0.40	GO:0005776	autophagosome
0.40	GO:0001726	ruffle
0.40	GO:0030027	lamellipodium
0.39	GO:0005739	mitochondrion
0.38	GO:0005874	microtubule
0.38	GO:0031410	cytoplasmic vesicle
0.34	GO:0005886	plasma membrane

0.37

GO:0016874

sp|O15554|KCNN4_HUMAN
Intermediate conductance calcium-activated potassium channel protein 4
Search

KCNN4

0.91	Intermediate-conductance calcium-activated potassium channel

0.73	GO:0071805	potassium ion transmembrane transport
0.56	GO:0046541	saliva secretion
0.56	GO:0050862	positive regulation of T cell receptor signaling pathway
0.55	GO:0030322	stabilization of membrane potential
0.54	GO:0006884	cell volume homeostasis
0.53	GO:0050714	positive regulation of protein secretion
0.52	GO:0045332	phospholipid translocation
0.50	GO:0006816	calcium ion transport
0.37	GO:0002376	immune system process
0.35	GO:1903955	positive regulation of protein targeting to mitochondrion

0.85	GO:0016286	small conductance calcium-activated potassium channel activity
0.78	GO:0005516	calmodulin binding
0.53	GO:0019903	protein phosphatase binding
0.37	GO:0022894	Intermediate conductance calcium-activated potassium channel activity
0.34	GO:0005249	voltage-gated potassium channel activity
0.33	GO:0046982	protein heterodimerization activity

0.49	GO:0043025	neuronal cell body
0.48	GO:0031982	vesicle
0.44	GO:0005886	plasma membrane
0.36	GO:0034705	potassium channel complex
0.35	GO:0005737	cytoplasm
0.35	GO:0045121	membrane raft
0.35	GO:0045177	apical part of cell
0.34	GO:0031594	neuromuscular junction
0.34	GO:0030175	filopodium
0.33	GO:0043005	neuron projection

sp|O43143|DHX15_HUMAN
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
Search

DHX15

0.81	DEAH (Asp-Glu-Ala-His) box polypeptide 15

0.48	GO:0000398	mRNA splicing, via spliceosome
0.44	GO:0043279	response to alkaloid
0.39	GO:0009636	response to toxic substance

0.67	GO:0004386	helicase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0003725	double-stranded RNA binding
0.49	GO:0008186	RNA-dependent ATPase activity
0.43	GO:0140098	catalytic activity, acting on RNA

0.58	GO:0071008	U2-type post-mRNA release spliceosomal complex
0.58	GO:0005689	U12-type spliceosomal complex
0.55	GO:0016607	nuclear speck
0.38	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O43147|SGSM2_HUMAN
Small G protein signaling modulator 2
Search

SGSM2

0.88	Small G protein signaling modulator 2

0.75	GO:0043547	positive regulation of GTPase activity
0.51	GO:0034499	late endosome to Golgi transport
0.47	GO:0031338	regulation of vesicle fusion
0.42	GO:0006886	intracellular protein transport
0.35	GO:0045944	positive regulation of transcription by RNA polymerase II
0.32	GO:0006520	cellular amino acid metabolic process

0.75	GO:0005096	GTPase activator activity
0.50	GO:0017137	Rab GTPase binding
0.33	GO:0030170	pyridoxal phosphate binding

0.49	GO:0042470	melanosome
0.41	GO:0012505	endomembrane system
0.37	GO:0030659	cytoplasmic vesicle membrane
0.36	GO:0005829	cytosol
0.32	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane

sp|O43148|MCES_HUMAN
mRNA cap guanine-N7 methyltransferase
Search

RNMT

0.76	mRNA cap guanine-N7 methyltransferase

0.77	GO:0106005	RNA 5'-cap (guanine-N7)-methylation
0.73	GO:0006370	7-methylguanosine mRNA capping
0.56	GO:1990830	cellular response to leukemia inhibitory factor
0.35	GO:0006366	transcription by RNA polymerase II

0.77	GO:0004482	mRNA (guanine-N7-)-methyltransferase activity
0.55	GO:0003723	RNA binding
0.34	GO:0005515	protein binding

0.61	GO:0005845	mRNA cap binding complex
0.60	GO:0005634	nucleus
0.54	GO:0043235	receptor complex
0.53	GO:0034708	methyltransferase complex
0.48	GO:0031974	membrane-enclosed lumen
0.44	GO:0043232	intracellular non-membrane-bounded organelle
0.44	GO:0044446	intracellular organelle part
0.30	GO:0016020	membrane

0.77

EC:2.1.1.56

GO:0004482

sp|O43149|ZZEF1_HUMAN
Zinc finger ZZ-type and EF-hand domain-containing protein 1
Search

ZZEF1

0.96	Zinc finger ZZ-type and EF-hand domain-containing protein 1

0.68	GO:0005509	calcium ion binding
0.63	GO:0008270	zinc ion binding

sp|O43150|ASAP2_HUMAN
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
Search

ASAP2

0.96	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

0.74

GO:0043547

positive regulation of GTPase activity

0.75	GO:0005096	GTPase activator activity
0.50	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.36	GO:0032580	Golgi cisterna membrane
0.33	GO:0005886	plasma membrane

sp|O43151|TET3_HUMAN
Methylcytosine dioxygenase TET3
Search

TET3

0.95	Tet methylcytosine dioxygenase 3

0.67	GO:0080182	histone H3-K4 trimethylation
0.62	GO:0006493	protein O-linked glycosylation
0.58	GO:0045944	positive regulation of transcription by RNA polymerase II
0.47	GO:0044727	DNA demethylation of male pronucleus
0.47	GO:0055114	oxidation-reduction process
0.44	GO:0080111	DNA demethylation
0.37	GO:0098508	endothelial to hematopoietic transition
0.36	GO:0030097	hemopoiesis

0.60	GO:0051213	dioxygenase activity
0.53	GO:0008270	zinc ion binding
0.48	GO:0003677	DNA binding
0.40	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.38	GO:0005515	protein binding

0.46	GO:0001940	male pronucleus
0.41	GO:0001939	female pronucleus
0.40	GO:0005694	chromosome
0.37	GO:0005654	nucleoplasm
0.35	GO:0005737	cytoplasm

0.40

GO:0016705

sp|O43155|FLRT2_HUMAN
Leucine-rich repeat transmembrane protein FLRT2
Search

FLRT2

0.93	Leucine-rich repeat transmembrane protein FLRT2

0.47	GO:0050919	negative chemotaxis
0.47	GO:0051965	positive regulation of synapse assembly
0.46	GO:0061343	cell adhesion involved in heart morphogenesis
0.46	GO:0008543	fibroblast growth factor receptor signaling pathway
0.45	GO:0071711	basement membrane organization
0.45	GO:0007411	axon guidance
0.45	GO:2001222	regulation of neuron migration
0.43	GO:0046426	negative regulation of JAK-STAT cascade
0.42	GO:0006469	negative regulation of protein kinase activity
0.41	GO:0019221	cytokine-mediated signaling pathway

0.48	GO:0045499	chemorepellent activity
0.47	GO:0005104	fibroblast growth factor receptor binding
0.42	GO:0004860	protein kinase inhibitor activity
0.38	GO:0042803	protein homodimerization activity
0.37	GO:0030674	protein binding, bridging
0.37	GO:0005057	signal transducer activity, downstream of receptor

0.46	GO:0005925	focal adhesion
0.44	GO:0005911	cell-cell junction
0.43	GO:0005615	extracellular space
0.41	GO:0005887	integral component of plasma membrane
0.41	GO:0043005	neuron projection
0.40	GO:0045202	synapse
0.40	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0005578	proteinaceous extracellular matrix
0.38	GO:1903561	extracellular vesicle
0.37	GO:0030427	site of polarized growth

sp|O43156|TTI1_HUMAN
TELO2-interacting protein 1 homolog
Search

TTI1

0.97	TELO2-interacting protein 1 homolog

0.80

GO:0032006

regulation of TOR signaling

0.53

GO:0005515

protein binding

0.83	GO:0031931	TORC1 complex
0.82	GO:0031932	TORC2 complex
0.49	GO:0005737	cytoplasm

sp|O43157|PLXB1_HUMAN
Plexin-B1
Search

0.86	Putative plexins functional semaphorin receptor

0.83	GO:0071526	semaphorin-plexin signaling pathway
0.62	GO:0033689	negative regulation of osteoblast proliferation
0.61	GO:0061430	bone trabecula morphogenesis
0.61	GO:0043931	ossification involved in bone maturation
0.60	GO:0050772	positive regulation of axonogenesis
0.59	GO:0007162	negative regulation of cell adhesion
0.59	GO:0048812	neuron projection morphogenesis
0.59	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
0.54	GO:0051493	regulation of cytoskeleton organization
0.54	GO:0043087	regulation of GTPase activity

0.84	GO:0017154	semaphorin receptor activity
0.61	GO:0032794	GTPase activating protein binding
0.37	GO:0030215	semaphorin receptor binding
0.36	GO:0005096	GTPase activator activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.65	GO:0002116	semaphorin receptor complex
0.50	GO:0005887	integral component of plasma membrane
0.34	GO:0005576	extracellular region
0.32	GO:0005622	intracellular

sp|O43159|RRP8_HUMAN
Ribosomal RNA-processing protein 8
Search

RRP8

0.82	Ribosomal RNA-processing protein 8

0.63	GO:0032259	methylation
0.59	GO:0046015	regulation of transcription by glucose
0.58	GO:0000183	chromatin silencing at rDNA
0.57	GO:0042149	cellular response to glucose starvation
0.56	GO:0071158	positive regulation of cell cycle arrest
0.56	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
0.38	GO:0016569	covalent chromatin modification
0.37	GO:0006364	rRNA processing
0.35	GO:0006351	transcription, DNA-templated

0.63	GO:0008168	methyltransferase activity
0.57	GO:0140034	methylation-dependent protein binding
0.55	GO:0042393	histone binding
0.34	GO:0003723	RNA binding
0.33	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

0.73	GO:0005730	nucleolus
0.59	GO:0005677	chromatin silencing complex
0.58	GO:0033553	rDNA heterochromatin
0.48	GO:0005829	cytosol
0.42	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.63

GO:0008168

sp|O43164|PJA2_HUMAN
E3 ubiquitin-protein ligase Praja-2
Search

PJA2

0.93	E3 ubiquitin-protein ligase Praja-2

0.84	GO:0010738	regulation of protein kinase A signaling
0.82	GO:0035329	hippo signaling
0.73	GO:0016567	protein ubiquitination
0.48	GO:0007616	long-term memory
0.37	GO:0030163	protein catabolic process

0.74	GO:0004842	ubiquitin-protein transferase activity
0.60	GO:0016874	ligase activity
0.54	GO:0034236	protein kinase A catalytic subunit binding
0.54	GO:0034237	protein kinase A regulatory subunit binding
0.50	GO:0061659	ubiquitin-like protein ligase activity
0.38	GO:0046872	metal ion binding

0.48	GO:0045111	intermediate filament cytoskeleton
0.47	GO:0014069	postsynaptic density
0.45	GO:0045211	postsynaptic membrane
0.44	GO:0030054	cell junction
0.44	GO:0000139	Golgi membrane
0.43	GO:0005789	endoplasmic reticulum membrane

0.60	EC:6	GO:0016874
0.74	KEGG:R03876	GO:0004842

sp|O43166|SI1L1_HUMAN
Signal-induced proliferation-associated 1-like protein 1
Search

SIPA1L1

0.91	Signal induced proliferation associated 1 like 1

0.85	GO:0048814	regulation of dendrite morphogenesis
0.76	GO:0031532	actin cytoskeleton reorganization
0.76	GO:0051056	regulation of small GTPase mediated signal transduction
0.76	GO:0043547	positive regulation of GTPase activity
0.67	GO:0048013	ephrin receptor signaling pathway
0.66	GO:0050770	regulation of axonogenesis

0.76	GO:0005096	GTPase activator activity
0.68	GO:0046875	ephrin receptor binding

sp|O43167|ZBT24_HUMAN
Zinc finger and BTB domain-containing protein 24
Search

ZBTB24

0.96	Zinc finger and BTB domain-containing protein 24

0.63	GO:0002244	hematopoietic progenitor cell differentiation
0.38	GO:2001141	regulation of RNA biosynthetic process
0.38	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.38	GO:0010468	regulation of gene expression
0.38	GO:0006351	transcription, DNA-templated
0.32	GO:0016310	phosphorylation

0.51	GO:0003676	nucleic acid binding
0.38	GO:0003700	DNA binding transcription factor activity
0.37	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding
0.33	GO:0019205	nucleobase-containing compound kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.39	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|O43169|CYB5B_HUMAN
Cytochrome b5 type B
Search

CYB5B

0.61	Outer mitochondrial membrane cytochrome b5 isoform B

0.37	GO:0043085	positive regulation of catalytic activity
0.36	GO:0006366	transcription by RNA polymerase II
0.36	GO:0071466	cellular response to xenobiotic stimulus
0.35	GO:0055114	oxidation-reduction process
0.34	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression
0.34	GO:0072663	establishment of protein localization to peroxisome
0.34	GO:0043574	peroxisomal transport
0.33	GO:0006605	protein targeting

0.61	GO:0020037	heme binding
0.53	GO:0046872	metal ion binding
0.37	GO:0008047	enzyme activator activity
0.36	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0045153	electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity
0.34	GO:0003700	DNA binding transcription factor activity
0.33	GO:0005515	protein binding
0.33	GO:0004252	serine-type endopeptidase activity
0.32	GO:0042623	ATPase activity, coupled
0.32	GO:0030554	adenyl nucleotide binding

0.43	GO:0031966	mitochondrial membrane
0.42	GO:0019866	organelle inner membrane
0.39	GO:0031968	organelle outer membrane
0.33	GO:0005778	peroxisomal membrane
0.33	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0004252

sp|O43172|PRP4_HUMAN
U4/U6 small nuclear ribonucleoprotein Prp4
Search

PRPF4

0.88	Pre-mRNA processing factor 4

0.48	GO:0000398	mRNA splicing, via spliceosome
0.44	GO:0060041	retina development in camera-type eye
0.43	GO:0043009	chordate embryonic development

0.57	GO:0030621	U4 snRNA binding
0.55	GO:0017070	U6 snRNA binding
0.34	GO:0005515	protein binding
0.32	GO:0003677	DNA binding

0.63	GO:0071001	U4/U6 snRNP
0.60	GO:0019013	viral nucleocapsid
0.59	GO:0015030	Cajal body
0.58	GO:0046540	U4/U6 x U5 tri-snRNP complex
0.57	GO:0016607	nuclear speck
0.40	GO:0005681	spliceosomal complex
0.33	GO:1902494	catalytic complex
0.30	GO:0031224	intrinsic component of membrane

sp|O43173|SIA8C_HUMAN
Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
Search

ST8SIA3

0.97	Z-linked ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3

0.83	GO:0097503	sialylation
0.74	GO:0006486	protein glycosylation
0.60	GO:0001574	ganglioside biosynthetic process
0.57	GO:0006491	N-glycan processing
0.51	GO:0009311	oligosaccharide metabolic process
0.46	GO:0046716	muscle cell cellular homeostasis
0.44	GO:0007517	muscle organ development
0.32	GO:0016051	carbohydrate biosynthetic process

0.83	GO:0008373	sialyltransferase activity
0.50	GO:0042802	identical protein binding
0.36	GO:0033691	sialic acid binding

0.69	GO:0005794	Golgi apparatus
0.37	GO:0098588	bounding membrane of organelle
0.37	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.83

GO:0008373

sp|O43174|CP26A_HUMAN
Cytochrome P450 26A1
Search

CYP26A1

0.97	Cytochrome P450 family 26 subfamily A polypeptide 1

0.80	GO:0034653	retinoic acid catabolic process
0.65	GO:0006805	xenobiotic metabolic process
0.53	GO:0016125	sterol metabolic process
0.53	GO:0055114	oxidation-reduction process
0.52	GO:0014032	neural crest cell development
0.50	GO:0009952	anterior/posterior pattern specification
0.49	GO:0007417	central nervous system development
0.49	GO:0048284	organelle fusion
0.38	GO:0071300	cellular response to retinoic acid
0.38	GO:0048384	retinoic acid receptor signaling pathway

0.83	GO:0008401	retinoic acid 4-hydroxylase activity
0.79	GO:0001972	retinoic acid binding
0.63	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
0.63	GO:0020037	heme binding
0.63	GO:0005506	iron ion binding

0.30

GO:0016020

membrane

0.63

EC:1.14.13

GO:0016709

sp|O43175|SERA_HUMAN
D-3-phosphoglycerate dehydrogenase
Search

PHGDH

0.52	Phosphoglycerate dehydrogenase

0.70	GO:0006564	L-serine biosynthetic process
0.57	GO:0070314	G1 to G0 transition
0.55	GO:0019530	taurine metabolic process
0.54	GO:0021510	spinal cord development
0.54	GO:0021782	glial cell development
0.53	GO:0021915	neural tube development
0.52	GO:0055114	oxidation-reduction process
0.51	GO:0009448	gamma-aminobutyric acid metabolic process
0.51	GO:0031175	neuron projection development
0.49	GO:0006566	threonine metabolic process

0.73	GO:0004617	phosphoglycerate dehydrogenase activity
0.67	GO:0051287	NAD binding
0.41	GO:0030060	L-malate dehydrogenase activity
0.33	GO:0000287	magnesium ion binding
0.33	GO:0009055	electron transfer activity
0.33	GO:0046983	protein dimerization activity

0.53	GO:0043209	myelin sheath
0.37	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol
0.32	GO:0005634	nucleus

0.73

EC:1.1.1.95

GO:0004617

sp|O43181|NDUS4_HUMAN
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Search

NDUFS4

0.89	Mitochondrial NADH dehydrogenase Fe-S protein 4

0.61	GO:0022900	electron transport chain
0.57	GO:0048146	positive regulation of fibroblast proliferation
0.56	GO:0051591	response to cAMP
0.56	GO:0032981	mitochondrial respiratory chain complex I assembly
0.55	GO:0019933	cAMP-mediated signaling
0.53	GO:0007420	brain development
0.50	GO:0072593	reactive oxygen species metabolic process
0.49	GO:0001932	regulation of protein phosphorylation
0.45	GO:0045333	cellular respiration
0.33	GO:0006119	oxidative phosphorylation

0.67

GO:0016651

oxidoreductase activity, acting on NAD(P)H

0.56	GO:0045271	respiratory chain complex I
0.55	GO:0005746	mitochondrial respiratory chain
0.53	GO:0098800	inner mitochondrial membrane protein complex
0.50	GO:1990204	oxidoreductase complex
0.30	GO:0016021	integral component of membrane

0.67

EC:1.6

GO:0016651

sp|O43182|RHG06_HUMAN
Rho GTPase-activating protein 6
Search

ARHGAP6

0.93	Rho GTPase-activating protein 6

0.74	GO:0043547	positive regulation of GTPase activity
0.73	GO:0007015	actin filament organization
0.60	GO:0007165	signal transduction
0.59	GO:0051497	negative regulation of stress fiber assembly
0.59	GO:0051895	negative regulation of focal adhesion assembly
0.58	GO:0048041	focal adhesion assembly
0.41	GO:0007202	activation of phospholipase C activity
0.36	GO:0051258	protein polymerization
0.35	GO:0051056	regulation of small GTPase mediated signal transduction
0.35	GO:0009967	positive regulation of signal transduction

0.75	GO:0005096	GTPase activator activity
0.42	GO:0016004	phospholipase activator activity
0.41	GO:0043274	phospholipase binding
0.38	GO:0017124	SH3 domain binding
0.37	GO:0005070	SH3/SH2 adaptor activity

0.50	GO:0015629	actin cytoskeleton
0.39	GO:0005737	cytoplasm
0.35	GO:0099513	polymeric cytoskeletal fiber

sp|O43184|ADA12_HUMAN
Disintegrin and metalloproteinase domain-containing protein 12
Search

ADAM12

0.94	Disintegrin and metalloproteinase domain-containing protein 12

0.60	GO:0006508	proteolysis
0.60	GO:0007229	integrin-mediated signaling pathway
0.54	GO:0045766	positive regulation of angiogenesis
0.36	GO:0007520	myoblast fusion
0.36	GO:0007155	cell adhesion
0.35	GO:0030198	extracellular matrix organization
0.32	GO:0006457	protein folding
0.32	GO:0006950	response to stress

0.69	GO:0004222	metalloendopeptidase activity
0.53	GO:0046872	metal ion binding
0.53	GO:0017124	SH3 domain binding
0.33	GO:0051082	unfolded protein binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.50	GO:0005615	extracellular space
0.48	GO:0005654	nucleoplasm
0.42	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.69

GO:0004222

sp|O43186|CRX_HUMAN
Cone-rod homeobox protein
Search

CRX

0.97	Cone-rod homeobox containing gene

0.76	GO:0007623	circadian rhythm
0.73	GO:0007601	visual perception
0.69	GO:0007275	multicellular organism development
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:0006366	transcription by RNA polymerase II
0.51	GO:0051254	positive regulation of RNA metabolic process
0.51	GO:0010557	positive regulation of macromolecule biosynthetic process
0.51	GO:0031328	positive regulation of cellular biosynthetic process

0.62	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.56	GO:0043522	leucine zipper domain binding
0.54	GO:0001012	RNA polymerase II regulatory region DNA binding
0.51	GO:0003690	double-stranded DNA binding
0.41	GO:0035257	nuclear hormone receptor binding
0.36	GO:0003682	chromatin binding

0.61	GO:0005634	nucleus
0.36	GO:0005667	transcription factor complex

sp|O43187|IRAK2_HUMAN
Interleukin-1 receptor-associated kinase-like 2
Search

IRAK2

0.90	Interleukin-1 receptor-associated kinase 2 transcript variant 1

0.86	GO:0070498	interleukin-1-mediated signaling pathway
0.85	GO:0007249	I-kappaB kinase/NF-kappaB signaling
0.84	GO:0002755	MyD88-dependent toll-like receptor signaling pathway
0.80	GO:0006954	inflammatory response
0.75	GO:0001959	regulation of cytokine-mediated signaling pathway
0.63	GO:0006468	protein phosphorylation
0.59	GO:0031663	lipopolysaccharide-mediated signaling pathway
0.59	GO:0032088	negative regulation of NF-kappaB transcription factor activity
0.58	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.46	GO:0032147	activation of protein kinase activity

0.63	GO:0004672	protein kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0042803	protein homodimerization activity
0.53	GO:0046982	protein heterodimerization activity

0.45	GO:0005622	intracellular
0.39	GO:0043227	membrane-bounded organelle
0.39	GO:0098805	whole membrane
0.38	GO:0012505	endomembrane system
0.36	GO:0044422	organelle part
0.35	GO:0005886	plasma membrane

sp|O43189|PHF1_HUMAN
PHD finger protein 1
Search

PHF1

0.95	PHD finger protein 1

0.79	GO:0031060	regulation of histone methylation
0.61	GO:0006974	cellular response to DNA damage stimulus
0.60	GO:0031057	negative regulation of histone modification
0.59	GO:0031058	positive regulation of histone modification
0.37	GO:0016569	covalent chromatin modification
0.36	GO:0010629	negative regulation of gene expression
0.36	GO:0019827	stem cell population maintenance
0.36	GO:0048863	stem cell differentiation
0.36	GO:0040029	regulation of gene expression, epigenetic
0.35	GO:1903506	regulation of nucleic acid-templated transcription

0.79	GO:0035064	methylated histone binding
0.51	GO:0046872	metal ion binding
0.38	GO:0003682	chromatin binding
0.34	GO:0003700	DNA binding transcription factor activity

0.60	GO:0035098	ESC/E(Z) complex
0.58	GO:0035861	site of double-strand break
0.55	GO:0005813	centrosome
0.33	GO:0005737	cytoplasm

sp|O43193|MTLR_HUMAN
Motilin receptor
Search

MLNR

0.95	Motilin receptor

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.43	GO:0007586	digestion

0.85

GO:0016520

growth hormone-releasing hormone receptor activity

0.39

GO:0005887

integral component of plasma membrane

sp|O43194|GPR39_HUMAN
G-protein coupled receptor 39
Search

GPR39

0.97	G-protein coupled receptor 39

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.38	GO:0035483	gastric emptying
0.38	GO:0060455	negative regulation of gastric acid secretion
0.38	GO:0002024	diet induced thermogenesis
0.38	GO:0071294	cellular response to zinc ion
0.38	GO:0008343	adult feeding behavior
0.37	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
0.37	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
0.37	GO:0042632	cholesterol homeostasis
0.37	GO:0000187	activation of MAPK activity

0.71	GO:0004930	G-protein coupled receptor activity
0.40	GO:0001653	peptide receptor activity
0.35	GO:0046872	metal ion binding
0.34	GO:0004984	olfactory receptor activity

0.38

GO:0005887

integral component of plasma membrane

sp|O43196|MSH5_HUMAN
MutS protein homolog 5
Search

MSH5

0.91	MutS protein like protein 5

0.75	GO:0006298	mismatch repair
0.45	GO:0051026	chiasma assembly
0.39	GO:0007292	female gamete generation

0.76	GO:0030983	mismatched DNA binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0003684	damaged DNA binding
0.40	GO:0008094	DNA-dependent ATPase activity
0.35	GO:0005515	protein binding

0.44	GO:0000795	synaptonemal complex
0.43	GO:0032300	mismatch repair complex
0.35	GO:0005654	nucleoplasm

sp|O43236|SEPT4_HUMAN
Septin-4
Search

SEPT4

0.93	Septin-4 isoform 1

0.54	GO:0030382	sperm mitochondrion organization
0.52	GO:0048240	sperm capacitation
0.52	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
0.50	GO:0031398	positive regulation of protein ubiquitination
0.49	GO:0051260	protein homooligomerization
0.49	GO:0007420	brain development
0.37	GO:0007179	transforming growth factor beta receptor signaling pathway
0.36	GO:0051301	cell division
0.36	GO:0007049	cell cycle
0.36	GO:0035335	peptidyl-tyrosine dephosphorylation

0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.48	GO:0042803	protein homodimerization activity
0.45	GO:0003924	GTPase activity
0.44	GO:0000287	magnesium ion binding
0.37	GO:0004722	protein serine/threonine phosphatase activity
0.36	GO:0004725	protein tyrosine phosphatase activity
0.33	GO:0004672	protein kinase activity

0.54	GO:0097227	sperm annulus
0.52	GO:0031105	septin complex
0.50	GO:0043209	myelin sheath
0.44	GO:0005654	nucleoplasm
0.42	GO:0005739	mitochondrion

0.36

GO:0004725

sp|O43237|DC1L2_HUMAN
Cytoplasmic dynein 1 light intermediate chain 2
Search

DYNC1LI2

0.94	Cytoplasmic dynein 1 light intermediate chain 2

0.74	GO:0007018	microtubule-based movement
0.54	GO:0051642	centrosome localization
0.50	GO:0000226	microtubule cytoskeleton organization
0.43	GO:0009794	regulation of mitotic cell cycle, embryonic
0.43	GO:0090235	regulation of metaphase plate congression
0.42	GO:0060236	regulation of mitotic spindle organization
0.40	GO:1990090	cellular response to nerve growth factor stimulus
0.38	GO:0051260	protein homooligomerization
0.35	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.34	GO:0006888	ER to Golgi vesicle-mediated transport

0.75	GO:0003777	microtubule motor activity
0.47	GO:0045504	dynein heavy chain binding
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0008641	ubiquitin-like modifier activating enzyme activity

0.83	GO:0005868	cytoplasmic dynein complex
0.51	GO:0005813	centrosome
0.38	GO:0005770	late endosome
0.38	GO:0005764	lysosome
0.38	GO:0005874	microtubule
0.38	GO:0000776	kinetochore
0.34	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O43240|KLK10_HUMAN
Kallikrein-10
Search

KLK10

0.84	Kallikrein J

0.61	GO:0006508	proteolysis
0.41	GO:0031642	negative regulation of myelination
0.41	GO:0043616	keratinocyte proliferation
0.41	GO:1903035	negative regulation of response to wounding
0.40	GO:0070571	negative regulation of neuron projection regeneration
0.40	GO:0048679	regulation of axon regeneration
0.40	GO:0032102	negative regulation of response to external stimulus
0.40	GO:0009611	response to wounding
0.40	GO:0007613	memory
0.39	GO:0050807	regulation of synapse organization

0.69	GO:0004252	serine-type endopeptidase activity
0.36	GO:0005044	scavenger receptor activity
0.36	GO:0030247	polysaccharide binding
0.34	GO:0005509	calcium ion binding
0.34	GO:0005515	protein binding
0.33	GO:0004713	protein tyrosine kinase activity
0.33	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
0.33	GO:0030545	receptor regulator activity
0.33	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0008201	heparin binding

0.41	GO:0097180	serine protease inhibitor complex
0.41	GO:0005576	extracellular region
0.34	GO:0005737	cytoplasm
0.34	GO:0031982	vesicle
0.33	GO:0012505	endomembrane system
0.32	GO:0043229	intracellular organelle
0.30	GO:0016020	membrane

0.69

GO:0004252

sp|O43242|PSMD3_HUMAN
26S proteasome non-ATPase regulatory subunit 3
Search

PSMD3

0.90	26S proteasome non-ATPase regulatory subunit 3

0.75	GO:0042176	regulation of protein catabolic process
0.67	GO:0050790	regulation of catalytic activity
0.46	GO:0008345	larval locomotory behavior
0.46	GO:0071599	otic vesicle development
0.45	GO:0006511	ubiquitin-dependent protein catabolic process
0.44	GO:0007420	brain development
0.36	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
0.36	GO:0002223	stimulatory C-type lectin receptor signaling pathway
0.36	GO:0038095	Fc-epsilon receptor signaling pathway
0.36	GO:1902036	regulation of hematopoietic stem cell differentiation

0.69	GO:0030234	enzyme regulator activity
0.35	GO:0005515	protein binding
0.33	GO:0030545	receptor regulator activity

0.71	GO:1905369	endopeptidase complex
0.58	GO:0043234	protein complex
0.44	GO:0005622	intracellular
0.37	GO:0070062	extracellular exosome
0.36	GO:0031983	vesicle lumen
0.35	GO:0012505	endomembrane system
0.30	GO:0016020	membrane

sp|O43246|CTR4_HUMAN
Cationic amino acid transporter 4
Search

SLC7A4

0.96	Cationic amino acid transporter 4

0.55	GO:0055085	transmembrane transport
0.38	GO:0006865	amino acid transport
0.33	GO:0006520	cellular amino acid metabolic process

0.57

GO:0022857

transmembrane transporter activity

0.30

GO:0016021

integral component of membrane

sp|O43247|TEX33_HUMAN
Testis-expressed protein 33
Search

TEX33

0.97	Testis-expressed protein 33

0.66

GO:0004792

thiosulfate sulfurtransferase activity

0.66	EC:2.8.1.1	GO:0004792
0.66	KEGG:R01931	GO:0004792

sp|O43248|HXC11_HUMAN
Homeobox protein Hox-C11
Search

HOXC11

0.97	Homeobox protein Hox-3H

0.58	GO:0060272	embryonic skeletal joint morphogenesis
0.58	GO:0001759	organ induction
0.57	GO:0009954	proximal/distal pattern formation
0.56	GO:0042733	embryonic digit morphogenesis
0.56	GO:0001656	metanephros development
0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.54	GO:0009952	anterior/posterior pattern specification
0.52	GO:0006366	transcription by RNA polymerase II

0.62	GO:0043565	sequence-specific DNA binding
0.55	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.53	GO:0001012	RNA polymerase II regulatory region DNA binding
0.50	GO:0003690	double-stranded DNA binding

0.60	GO:0005634	nucleus
0.49	GO:0005829	cytosol
0.48	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part

sp|O43251|RFOX2_HUMAN
RNA binding protein fox-1 homolog 2
Search

RBFOX2

0.86	RNA binding protein fox-1 homolog

0.80	GO:0043484	regulation of RNA splicing
0.65	GO:0008380	RNA splicing
0.62	GO:0006397	mRNA processing
0.56	GO:0010724	regulation of definitive erythrocyte differentiation
0.56	GO:0021942	radial glia guided migration of Purkinje cell
0.56	GO:0030520	intracellular estrogen receptor signaling pathway
0.53	GO:0050885	neuromuscular process controlling balance
0.53	GO:0048813	dendrite morphogenesis
0.52	GO:0050684	regulation of mRNA processing
0.49	GO:0045892	negative regulation of transcription, DNA-templated

0.59	GO:0003723	RNA binding
0.53	GO:0003714	transcription corepressor activity
0.49	GO:0008134	transcription factor binding

0.56	GO:0005634	nucleus
0.48	GO:0005829	cytosol
0.47	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part

sp|O43252|PAPS1_HUMAN
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Search

PAPSS1

0.96	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1

0.76	GO:0000103	sulfate assimilation
0.62	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
0.57	GO:0016310	phosphorylation
0.39	GO:0001501	skeletal system development
0.38	GO:0007596	blood coagulation
0.37	GO:0048513	animal organ development
0.35	GO:0070814	hydrogen sulfide biosynthetic process

0.79	GO:0004020	adenylylsulfate kinase activity
0.78	GO:0004781	sulfate adenylyltransferase (ATP) activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0042803	protein homodimerization activity
0.36	GO:0098616	selenate adenylyltransferase (ATP) activity

0.36	GO:0009336	sulfate adenylyltransferase complex (ATP)
0.35	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:2.7.1.25

GO:0004020

sp|O43255|SIAH2_HUMAN
E3 ubiquitin-protein ligase SIAH2
Search

SIAH2

0.55	E3 ubiquitin-protein ligase

0.73	GO:0006511	ubiquitin-dependent protein catabolic process
0.72	GO:0016567	protein ubiquitination
0.70	GO:0007275	multicellular organism development
0.54	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
0.54	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.53	GO:0090090	negative regulation of canonical Wnt signaling pathway
0.39	GO:0031396	regulation of protein ubiquitination
0.38	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
0.38	GO:0006915	apoptotic process
0.37	GO:0007049	cell cycle

0.63	GO:0008270	zinc ion binding
0.52	GO:0016874	ligase activity
0.40	GO:0031624	ubiquitin conjugating enzyme binding
0.39	GO:0004842	ubiquitin-protein transferase activity
0.38	GO:0008022	protein C-terminus binding
0.37	GO:0061659	ubiquitin-like protein ligase activity
0.36	GO:0042802	identical protein binding
0.35	GO:0003714	transcription corepressor activity

0.61	GO:0005634	nucleus
0.47	GO:0005829	cytosol
0.46	GO:0031974	membrane-enclosed lumen
0.42	GO:0044446	intracellular organelle part
0.39	GO:0005769	early endosome
0.39	GO:0043025	neuronal cell body
0.38	GO:0030877	beta-catenin destruction complex
0.38	GO:0043005	neuron projection
0.32	GO:0005886	plasma membrane

0.52	EC:6	GO:0016874
0.39	KEGG:R03876	GO:0004842

sp|O43257|ZNHI1_HUMAN
Zinc finger HIT domain-containing protein 1
Search

ZNHIT1

0.96	Zinc finger HIT domain-containing protein 1

0.50	GO:0031063	regulation of histone deacetylation
0.48	GO:0043486	histone exchange
0.39	GO:0070317	negative regulation of G0 to G1 transition
0.38	GO:0042129	regulation of T cell proliferation
0.37	GO:0000122	negative regulation of transcription by RNA polymerase II
0.33	GO:0006955	immune response
0.33	GO:0006289	nucleotide-excision repair
0.33	GO:0006099	tricarboxylic acid cycle
0.32	GO:0006468	protein phosphorylation

0.53	GO:0046872	metal ion binding
0.49	GO:0042826	histone deacetylase binding
0.48	GO:0031491	nucleosome binding
0.34	GO:0005164	tumor necrosis factor receptor binding
0.33	GO:0003994	aconitate hydratase activity
0.32	GO:0051539	4 iron, 4 sulfur cluster binding
0.32	GO:0004672	protein kinase activity
0.31	GO:0030554	adenyl nucleotide binding
0.31	GO:0032555	purine ribonucleotide binding
0.31	GO:0008144	drug binding

0.48	GO:0031981	nuclear lumen
0.44	GO:0000785	chromatin
0.42	GO:1904949	ATPase complex
0.36	GO:0005700	polytene chromosome
0.33	GO:0000439	core TFIIH complex
0.32	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.33

EC:4.2.1.3

GO:0003994

sp|O43261|LEU1_HUMAN
Leukemia-associated protein 1
Search

0.40	Leukemia-associated protein 1

0.63

GO:0005515

protein binding

sp|O43264|ZW10_HUMAN
Centromere/kinetochore protein zw10 homolog
Search

ZW10

0.84	Centromere/kinetochore protein zw10

0.73	GO:0000278	mitotic cell cycle
0.58	GO:0034501	protein localization to kinetochore
0.57	GO:0051294	establishment of spindle orientation
0.57	GO:0051310	metaphase plate congression
0.56	GO:0007096	regulation of exit from mitosis
0.56	GO:0007030	Golgi organization
0.55	GO:0045930	negative regulation of mitotic cell cycle
0.55	GO:0000075	cell cycle checkpoint
0.55	GO:0006888	ER to Golgi vesicle-mediated transport
0.53	GO:0000819	sister chromatid segregation

0.36	GO:0019237	centromeric DNA binding
0.34	GO:0005515	protein binding

0.75	GO:0000775	chromosome, centromeric region
0.61	GO:0070939	Dsl1/NZR complex
0.60	GO:0005634	nucleus
0.58	GO:0005828	kinetochore microtubule
0.54	GO:0000922	spindle pole
0.49	GO:0005829	cytosol
0.39	GO:0000793	condensed chromosome
0.38	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

sp|O43272|PROD_HUMAN
Proline dehydrogenase 1, mitochondrial
Search

0.56	Proline dehydrogenase

0.79	GO:0006562	proline catabolic process
0.52	GO:0055114	oxidation-reduction process
0.44	GO:0006536	glutamate metabolic process
0.38	GO:0010942	positive regulation of cell death
0.37	GO:0019470	4-hydroxyproline catabolic process
0.36	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
0.34	GO:0042331	phototaxis
0.34	GO:0007626	locomotory behavior

0.80	GO:0004657	proline dehydrogenase activity
0.45	GO:0071949	FAD binding
0.38	GO:0016597	amino acid binding

0.44	GO:0005739	mitochondrion
0.43	GO:0019866	organelle inner membrane
0.36	GO:0043233	organelle lumen

0.80

EC:1.5.99.8

GO:0004657

sp|O43278|SPIT1_HUMAN
Kunitz-type protease inhibitor 1
Search

SPINT1

0.97	Hepatocyte growth factor activator inhibitor type 1

0.76	GO:0010951	negative regulation of endopeptidase activity
0.62	GO:0060670	branching involved in labyrinthine layer morphogenesis
0.61	GO:0001843	neural tube closure
0.61	GO:0060674	placenta blood vessel development
0.58	GO:0030198	extracellular matrix organization
0.50	GO:0006508	proteolysis
0.43	GO:0045687	positive regulation of glial cell differentiation
0.43	GO:2000178	negative regulation of neural precursor cell proliferation
0.42	GO:0071773	cellular response to BMP stimulus
0.35	GO:0008544	epidermis development

0.79	GO:0004867	serine-type endopeptidase inhibitor activity
0.50	GO:0008233	peptidase activity
0.33	GO:0005509	calcium ion binding
0.32	GO:0030492	hemoglobin binding
0.32	GO:0008061	chitin binding
0.32	GO:0050750	low-density lipoprotein particle receptor binding
0.32	GO:0035258	steroid hormone receptor binding
0.32	GO:0030165	PDZ domain binding
0.32	GO:0042562	hormone binding
0.32	GO:0017124	SH3 domain binding

0.44	GO:0005886	plasma membrane
0.40	GO:0070062	extracellular exosome
0.32	GO:0005903	brush border
0.32	GO:0030139	endocytic vesicle
0.32	GO:0005905	clathrin-coated pit
0.32	GO:0030425	dendrite
0.32	GO:0045177	apical part of cell
0.32	GO:0030424	axon
0.32	GO:0043235	receptor complex
0.32	GO:0009986	cell surface

0.50

GO:0008233

sp|O43280|TREA_HUMAN
Trehalase
Search

TREH

0.65

Trehalase

0.77	GO:0005991	trehalose metabolic process
0.39	GO:0009887	animal organ morphogenesis
0.39	GO:0046352	disaccharide catabolic process
0.38	GO:0097150	neuronal stem cell population maintenance
0.33	GO:0006886	intracellular protein transport
0.33	GO:0016192	vesicle-mediated transport
0.33	GO:0071474	cellular hyperosmotic response

0.82	GO:0004555	alpha,alpha-trehalase activity
0.32	GO:0004386	helicase activity
0.31	GO:0030554	adenyl nucleotide binding
0.31	GO:0032555	purine ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding
0.31	GO:0003676	nucleic acid binding

0.38	GO:0070062	extracellular exosome
0.38	GO:0031225	anchored component of membrane
0.35	GO:0005903	brush border
0.34	GO:0005886	plasma membrane
0.32	GO:0042597	periplasmic space
0.31	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

0.82

EC:3.2.1.28

GO:0004555

sp|O43281|EFS_HUMAN
Embryonal Fyn-associated substrate
Search

EFS

0.97	Embryonal Fyn-associated substrate

0.43	GO:0007018	microtubule-based movement
0.42	GO:0007155	cell adhesion
0.41	GO:0007165	signal transduction
0.37	GO:0030334	regulation of cell migration
0.37	GO:0035729	cellular response to hepatocyte growth factor stimulus
0.36	GO:2000147	positive regulation of cell motility
0.36	GO:0002253	activation of immune response
0.36	GO:0016477	cell migration
0.36	GO:0007015	actin filament organization
0.35	GO:0043547	positive regulation of GTPase activity

0.76	GO:0017124	SH3 domain binding
0.44	GO:0051015	actin filament binding
0.43	GO:0003777	microtubule motor activity
0.43	GO:0008017	microtubule binding
0.40	GO:0004871	signal transducer activity
0.37	GO:0032559	adenyl ribonucleotide binding
0.37	GO:0008144	drug binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005096	GTPase activator activity
0.35	GO:0019901	protein kinase binding

0.43	GO:0016459	myosin complex
0.37	GO:0001726	ruffle
0.36	GO:0005925	focal adhesion
0.36	GO:0030027	lamellipodium
0.35	GO:0005737	cytoplasm
0.33	GO:0005886	plasma membrane
0.32	GO:0030426	growth cone
0.32	GO:0005874	microtubule
0.32	GO:0012505	endomembrane system
0.31	GO:0043231	intracellular membrane-bounded organelle

sp|O43283|M3K13_HUMAN
Mitogen-activated protein kinase kinase kinase 13
Search

MAP3K13

0.88	Mitogen-activated protein kinase kinase kinase

0.83	GO:0000186	activation of MAPKK activity
0.80	GO:0046777	protein autophosphorylation
0.78	GO:0000165	MAPK cascade
0.67	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.66	GO:0031098	stress-activated protein kinase signaling cascade

0.83	GO:0004709	MAP kinase kinase kinase activity
0.59	GO:0042803	protein homodimerization activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0046872	metal ion binding
0.35	GO:0019901	protein kinase binding
0.32	GO:0003700	DNA binding transcription factor activity

0.64	GO:0008385	IkappaB kinase complex
0.32	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.83

EC:2.7.11 EC:2.7.11.25

GO:0004709

sp|O43286|B4GT5_HUMAN
Beta-1,4-galactosyltransferase 5
Search

B4GALT5

0.96	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6

0.60	GO:0005975	carbohydrate metabolic process
0.48	GO:0006687	glycosphingolipid metabolic process
0.44	GO:0046513	ceramide biosynthetic process
0.41	GO:0009247	glycolipid biosynthetic process
0.36	GO:0009101	glycoprotein biosynthetic process
0.36	GO:0018146	keratan sulfate biosynthetic process
0.35	GO:0043413	macromolecule glycosylation
0.35	GO:0046457	prostanoid biosynthetic process
0.35	GO:0006693	prostaglandin metabolic process
0.35	GO:0048840	otolith development

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.35	GO:0008116	prostaglandin-I synthase activity
0.34	GO:0046872	metal ion binding
0.33	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.33	GO:0004497	monooxygenase activity
0.33	GO:0020037	heme binding

0.36	GO:0032580	Golgi cisterna membrane
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.65	EC:2.4	GO:0016757
0.35	KEGG:R02267	GO:0008116

sp|O43290|SNUT1_HUMAN
U4/U6.U5 tri-snRNP-associated protein 1
Search

SART1

0.92	Squamous cell carcinoma antigen recognised by cytotoxic T lymphocytes

0.75	GO:0000398	mRNA splicing, via spliceosome
0.64	GO:0045583	regulation of cytotoxic T cell differentiation
0.59	GO:0045582	positive regulation of T cell differentiation
0.53	GO:0000481	maturation of 5S rRNA
0.46	GO:0022618	ribonucleoprotein complex assembly
0.36	GO:0097193	intrinsic apoptotic signaling pathway
0.36	GO:0007050	cell cycle arrest
0.33	GO:0006486	protein glycosylation
0.33	GO:0006635	fatty acid beta-oxidation

0.35	GO:0003723	RNA binding
0.34	GO:0005515	protein binding
0.34	GO:0008378	galactosyltransferase activity
0.33	GO:0003997	acyl-CoA oxidase activity

0.59	GO:0015030	Cajal body
0.56	GO:0071013	catalytic step 2 spliceosome
0.56	GO:0016607	nuclear speck
0.51	GO:0005794	Golgi apparatus
0.48	GO:0046540	U4/U6 x U5 tri-snRNP complex
0.35	GO:0005829	cytosol
0.32	GO:0005777	peroxisome
0.30	GO:0016020	membrane

0.34

GO:0008378

sp|O43291|SPIT2_HUMAN
Kunitz-type protease inhibitor 2
Search

SPINT2

0.96	Hepatocyte growth factor activator inhibitor type 2

0.76	GO:0010951	negative regulation of endopeptidase activity
0.64	GO:0060671	epithelial cell differentiation involved in embryonic placenta development
0.63	GO:0060670	branching involved in labyrinthine layer morphogenesis
0.61	GO:0071711	basement membrane organization
0.61	GO:0003382	epithelial cell morphogenesis
0.60	GO:0001843	neural tube closure
0.59	GO:0022408	negative regulation of cell-cell adhesion
0.58	GO:2000146	negative regulation of cell motility
0.57	GO:0007163	establishment or maintenance of cell polarity
0.47	GO:0006508	proteolysis

0.79	GO:0004867	serine-type endopeptidase inhibitor activity
0.47	GO:0008233	peptidase activity
0.35	GO:0008201	heparin binding
0.33	GO:0046914	transition metal ion binding

0.41	GO:0005576	extracellular region
0.40	GO:0005737	cytoplasm
0.36	GO:0005886	plasma membrane
0.33	GO:0097223	sperm part
0.33	GO:0005634	nucleus
0.33	GO:0045121	membrane raft
0.33	GO:0005581	collagen trimer
0.33	GO:0009986	cell surface
0.33	GO:0097708	intracellular vesicle
0.32	GO:0012505	endomembrane system

0.47

GO:0008233

sp|O43292|GPAA1_HUMAN
Glycosylphosphatidylinositol anchor attachment 1 protein
Search

GPAA1

0.95	Glycosylphosphatidylinositol anchor attachment

0.49	GO:0016255	attachment of GPI anchor to protein
0.36	GO:0006621	protein retention in ER lumen
0.34	GO:0006461	protein complex assembly
0.32	GO:0022900	electron transport chain

0.60	GO:0034235	GPI anchor binding
0.40	GO:0003923	GPI-anchor transamidase activity
0.35	GO:0015631	tubulin binding
0.32	GO:0020037	heme binding
0.32	GO:0009055	electron transfer activity
0.32	GO:0046872	metal ion binding

0.81	GO:0042765	GPI-anchor transamidase complex
0.34	GO:0005887	integral component of plasma membrane

0.40

GO:0003923

sp|O43293|DAPK3_HUMAN
Death-associated protein kinase 3
Search

DAPK3

0.97	Death-associated protein kinase 3

0.62	GO:0006468	protein phosphorylation
0.58	GO:0006915	apoptotic process
0.57	GO:0043519	regulation of myosin II filament organization
0.55	GO:0071346	cellular response to interferon-gamma
0.54	GO:2000249	regulation of actin cytoskeleton reorganization
0.54	GO:0090109	regulation of cell-substrate junction assembly
0.54	GO:1903391	regulation of adherens junction organization
0.53	GO:0001952	regulation of cell-matrix adhesion
0.53	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.52	GO:0030335	positive regulation of cell migration

0.66	GO:0004674	protein serine/threonine kinase activity
0.56	GO:0043522	leucine zipper domain binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0008144	drug binding
0.50	GO:0017048	Rho GTPase binding
0.49	GO:0042803	protein homodimerization activity
0.39	GO:0008022	protein C-terminus binding
0.36	GO:0017075	syntaxin-1 binding

0.54	GO:0016605	PML body
0.39	GO:0005884	actin filament
0.39	GO:0098857	membrane microdomain
0.38	GO:0005737	cytoplasm
0.36	GO:0000775	chromosome, centromeric region
0.34	GO:0005815	microtubule organizing center
0.33	GO:0005886	plasma membrane

0.66

GO:0004674

sp|O43294|TGFI1_HUMAN
Transforming growth factor beta-1-induced transcript 1 protein
Search

TGFB1I1

0.87	Transforming growth factor beta 1 induced transcript 1

0.58	GO:0007160	cell-matrix adhesion
0.56	GO:0030579	ubiquitin-dependent SMAD protein catabolic process
0.55	GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus
0.54	GO:0010718	positive regulation of epithelial to mesenchymal transition
0.54	GO:0045599	negative regulation of fat cell differentiation
0.53	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.53	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
0.52	GO:0016331	morphogenesis of embryonic epithelium
0.51	GO:0045165	cell fate commitment
0.51	GO:0030855	epithelial cell differentiation

0.56	GO:0048495	Roundabout binding
0.55	GO:0070411	I-SMAD binding
0.55	GO:0050681	androgen receptor binding
0.53	GO:0046872	metal ion binding
0.51	GO:0003713	transcription coactivator activity
0.50	GO:0017166	vinculin binding
0.41	GO:0038191	neuropilin binding
0.40	GO:0008013	beta-catenin binding
0.33	GO:0004867	serine-type endopeptidase inhibitor activity

0.58	GO:0005925	focal adhesion
0.52	GO:0005856	cytoskeleton
0.49	GO:0031012	extracellular matrix
0.41	GO:0016363	nuclear matrix
0.40	GO:0030027	lamellipodium
0.38	GO:0005886	plasma membrane
0.37	GO:0005829	cytosol
0.33	GO:0005938	cell cortex
0.32	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

sp|O43295|SRGP3_HUMAN
SLIT-ROBO Rho GTPase-activating protein 3
Search

SRGAP3

0.92	SLIT-ROBO Rho GTPase activating protein 3

0.73	GO:0043547	positive regulation of GTPase activity
0.59	GO:0007165	signal transduction
0.47	GO:0030336	negative regulation of cell migration
0.35	GO:0051056	regulation of small GTPase mediated signal transduction

0.73	GO:0005096	GTPase activator activity
0.49	GO:0048365	Rac GTPase binding
0.33	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity

0.36	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:3.1.4.17

GO:0004114

sp|O43296|ZN264_HUMAN
Zinc finger protein 264
Search

0.67	Zinc finger domain-containing protein (Fragment)

0.54	GO:1903506	regulation of nucleic acid-templated transcription
0.54	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.53	GO:0010468	regulation of gene expression
0.37	GO:0006468	protein phosphorylation
0.34	GO:0006351	transcription, DNA-templated

0.51	GO:0003676	nucleic acid binding
0.51	GO:0046872	metal ion binding
0.37	GO:0004672	protein kinase activity
0.36	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005515	protein binding
0.34	GO:0003700	DNA binding transcription factor activity

0.43	GO:0005622	intracellular
0.35	GO:0043227	membrane-bounded organelle
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0043228	non-membrane-bounded organelle
0.34	GO:0044422	organelle part

sp|O43298|ZBT43_HUMAN
Zinc finger and BTB domain-containing protein 43
Search

ZBTB43

0.97	Zinc finger and BTB domain-containing protein 43

0.36	GO:2001141	regulation of RNA biosynthetic process
0.36	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.36	GO:0010468	regulation of gene expression
0.35	GO:0006351	transcription, DNA-templated
0.32	GO:0034249	negative regulation of cellular amide metabolic process
0.32	GO:0032269	negative regulation of cellular protein metabolic process
0.32	GO:0051253	negative regulation of RNA metabolic process
0.31	GO:0010558	negative regulation of macromolecule biosynthetic process
0.31	GO:0031327	negative regulation of cellular biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.35	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding
0.32	GO:0030371	translation repressor activity
0.31	GO:0003700	DNA binding transcription factor activity

0.43	GO:0005634	nucleus
0.38	GO:0031974	membrane-enclosed lumen
0.36	GO:0044446	intracellular organelle part
0.31	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O43299|AP5Z1_HUMAN
AP-5 complex subunit zeta-1
Search

AP5Z1

0.97	AP-5 complex subunit zeta-1

0.54	GO:0016197	endosomal transport
0.53	GO:0000724	double-strand break repair via homologous recombination
0.37	GO:2001141	regulation of RNA biosynthetic process
0.37	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.37	GO:0010468	regulation of gene expression
0.35	GO:0015031	protein transport
0.35	GO:0000045	autophagosome assembly

0.39	GO:0043565	sequence-specific DNA binding
0.38	GO:0003700	DNA binding transcription factor activity
0.35	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding
0.35	GO:0032266	phosphatidylinositol-3-phosphate binding
0.34	GO:0005515	protein binding

0.86	GO:0044599	AP-5 adaptor complex
0.55	GO:0016607	nuclear speck
0.35	GO:0000407	phagophore assembly site

sp|O43300|LRRT2_HUMAN
Leucine-rich repeat transmembrane neuronal protein 2
Search

LRRTM2

0.97	Leucine-rich repeat transmembrane neuronal protein 2

0.61	GO:0002091	negative regulation of receptor internalization
0.58	GO:0060291	long-term synaptic potentiation
0.58	GO:0051965	positive regulation of synapse assembly
0.55	GO:0050808	synapse organization
0.40	GO:1902004	positive regulation of amyloid-beta formation
0.38	GO:0046426	negative regulation of JAK-STAT cascade
0.37	GO:0006469	negative regulation of protein kinase activity
0.37	GO:0019221	cytokine-mediated signaling pathway

0.41	GO:0042802	identical protein binding
0.39	GO:0042043	neurexin family protein binding
0.38	GO:0004860	protein kinase inhibitor activity

0.39	GO:0060076	excitatory synapse
0.39	GO:0045211	postsynaptic membrane
0.38	GO:0030054	cell junction
0.33	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|O43301|HS12A_HUMAN
Heat shock 70 kDa protein 12A
Search

HSPA12A

0.90	Heat shock protein 12A

0.50	GO:0030554	adenyl nucleotide binding
0.50	GO:0097367	carbohydrate derivative binding
0.50	GO:0008144	drug binding
0.50	GO:0035639	purine ribonucleoside triphosphate binding

0.72

GO:0070062

extracellular exosome

sp|O43303|CP110_HUMAN
Centriolar coiled-coil protein of 110 kDa
Search

CCP110

0.97	Centriolar coiled-coil protein of isoform A

0.84	GO:0007099	centriole replication
0.78	GO:0032465	regulation of cytokinesis
0.65	GO:0032053	ciliary basal body organization
0.65	GO:1902018	negative regulation of cilium assembly
0.63	GO:0045724	positive regulation of cilium assembly
0.38	GO:0097711	ciliary basal body-plasma membrane docking
0.37	GO:0000086	G2/M transition of mitotic cell cycle
0.37	GO:0010389	regulation of G2/M transition of mitotic cell cycle
0.36	GO:0016579	protein deubiquitination

0.35

GO:0005515

protein binding

0.82	GO:0005814	centriole
0.58	GO:0005813	centrosome
0.47	GO:0043234	protein complex
0.37	GO:0005929	cilium
0.35	GO:0005829	cytosol

sp|O43304|S14L5_HUMAN
SEC14-like protein 5
Search

SEC14L5

0.82	SEC14 like lipid binding 5

0.87	GO:0039536	negative regulation of RIG-I signaling pathway
0.83	GO:0015871	choline transport
0.66	GO:0065009	regulation of molecular function

0.88	GO:0039552	RIG-I binding
0.69	GO:0098772	molecular function regulator

0.72	GO:0005794	Golgi apparatus
0.70	GO:0005654	nucleoplasm
0.69	GO:0005829	cytosol

sp|O43306|ADCY6_HUMAN
Adenylate cyclase type 6
Search

ADCY6

0.81	Adenylate cyclase type 6

0.79	GO:0006171	cAMP biosynthetic process
0.65	GO:1904321	response to forskolin
0.62	GO:0035556	intracellular signal transduction
0.62	GO:1901655	cellular response to ketone
0.61	GO:0007212	dopamine receptor signaling pathway
0.60	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
0.59	GO:0035690	cellular response to drug
0.58	GO:0071379	cellular response to prostaglandin stimulus
0.58	GO:0034695	response to prostaglandin E
0.58	GO:0071870	cellular response to catecholamine stimulus

0.79	GO:0004016	adenylate cyclase activity
0.57	GO:0005080	protein kinase C binding
0.53	GO:0030554	adenyl nucleotide binding
0.52	GO:0097367	carbohydrate derivative binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0004383	guanylate cyclase activity
0.50	GO:0097110	scaffold protein binding
0.50	GO:0008179	adenylate cyclase binding
0.44	GO:0046982	protein heterodimerization activity

0.55	GO:0005886	plasma membrane
0.52	GO:0008074	guanylate cyclase complex, soluble
0.48	GO:0005929	cilium
0.45	GO:0045111	intermediate filament cytoskeleton
0.36	GO:0098857	membrane microdomain
0.35	GO:0005768	endosome
0.35	GO:0005902	microvillus
0.34	GO:0120038	plasma membrane bounded cell projection part
0.30	GO:0016021	integral component of membrane

0.79

EC:4.6.1.1

GO:0004016

sp|O43307|ARHG9_HUMAN
Rho guanine nucleotide exchange factor 9
Search

ARHGEF9

0.96	Rho guanine nucleotide exchange factor 9

0.77	GO:0035023	regulation of Rho protein signal transduction
0.65	GO:0065009	regulation of molecular function
0.35	GO:0046847	filopodium assembly
0.35	GO:0043113	receptor clustering
0.35	GO:0002040	sprouting angiogenesis
0.34	GO:0043065	positive regulation of apoptotic process
0.34	GO:0007264	small GTPase mediated signal transduction
0.34	GO:0007186	G-protein coupled receptor signaling pathway

0.77

GO:0005089

Rho guanyl-nucleotide exchange factor activity

0.45	GO:0005829	cytosol
0.35	GO:0005938	cell cortex
0.32	GO:0005886	plasma membrane

sp|O43309|ZSC12_HUMAN
Zinc finger and SCAN domain-containing protein 12
Search

0.83	Zinc finger with KRAB and SCAN domains 3

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:0006351	transcription, DNA-templated
0.45	GO:0015074	DNA integration

0.61	GO:0003700	DNA binding transcription factor activity
0.48	GO:0003676	nucleic acid binding
0.48	GO:0046872	metal ion binding
0.38	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.37	GO:0031974	membrane-enclosed lumen
0.35	GO:0044446	intracellular organelle part
0.34	GO:0070062	extracellular exosome
0.34	GO:0005737	cytoplasm

sp|O43310|CTIF_HUMAN
CBP80/20-dependent translation initiation factor
Search

CTIF

0.97	Cap binding complex dependent translation initiation factor

0.58	GO:0006413	translational initiation
0.58	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
0.55	GO:0006446	regulation of translational initiation

0.59	GO:0003743	translation initiation factor activity
0.34	GO:0005515	protein binding

0.56	GO:0048471	perinuclear region of cytoplasm
0.50	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O43312|MTSS1_HUMAN
Metastasis suppressor protein 1
Search

MTSS1

0.87	Metastasis suppressor protein 1

0.82	GO:0007009	plasma membrane organization
0.74	GO:0030036	actin cytoskeleton organization
0.52	GO:0072160	nephron tubule epithelial cell differentiation
0.51	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis
0.51	GO:0072102	glomerulus morphogenesis
0.50	GO:0071498	cellular response to fluid shear stress
0.48	GO:0050680	negative regulation of epithelial cell proliferation
0.40	GO:0034334	adherens junction maintenance
0.39	GO:0010960	magnesium ion homeostasis
0.39	GO:0030282	bone mineralization

0.74	GO:0003779	actin binding
0.48	GO:0042802	identical protein binding
0.47	GO:0005102	receptor binding
0.37	GO:0032403	protein complex binding

0.48	GO:0015629	actin cytoskeleton
0.38	GO:0005912	adherens junction
0.36	GO:0001726	ruffle
0.36	GO:0030139	endocytic vesicle

sp|O43313|ATMIN_HUMAN
ATM interactor
Search

ATMIN

0.97	LOW QUALITY PROTEIN: ATM interactor

0.72	GO:1902857	positive regulation of non-motile cilium assembly
0.69	GO:0044458	motile cilium assembly
0.60	GO:0045893	positive regulation of transcription, DNA-templated
0.40	GO:0034508	centromere complex assembly
0.38	GO:0007059	chromosome segregation
0.38	GO:0006974	cellular response to DNA damage stimulus
0.36	GO:0006351	transcription, DNA-templated

0.68	GO:0070840	dynein complex binding
0.61	GO:0044212	transcription regulatory region DNA binding
0.36	GO:0046872	metal ion binding

0.63

GO:0016604

nuclear body

sp|O43314|VIP2_HUMAN
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
Search

PPIP5K2

0.92	Diphosphoinositol pentakisphosphate kinase 2

0.57	GO:0016310	phosphorylation
0.54	GO:0032958	inositol phosphate biosynthetic process
0.52	GO:0006020	inositol metabolic process

0.85	GO:0000829	inositol heptakisphosphate kinase activity
0.75	GO:0033857	diphosphoinositol-pentakisphosphate kinase activity
0.75	GO:0000828	inositol hexakisphosphate kinase activity

0.47

GO:0005829

cytosol

0.75

EC:2.7.4.24

GO:0033857

sp|O43315|AQP9_HUMAN
Aquaporin-9
Search

AQP9

0.93	Aquaporin-9 isoform A

0.60	GO:0006833	water transport
0.59	GO:1904823	purine nucleobase transmembrane transport
0.58	GO:0071320	cellular response to cAMP
0.57	GO:0015837	amine transport
0.56	GO:0015791	polyol transport
0.55	GO:0046689	response to mercury ion
0.54	GO:0072531	pyrimidine-containing compound transmembrane transport
0.54	GO:0015855	pyrimidine nucleobase transport
0.41	GO:0071918	urea transmembrane transport
0.38	GO:0015722	canalicular bile acid transport

0.69	GO:0022803	passive transmembrane transporter activity
0.59	GO:0005345	purine nucleobase transmembrane transporter activity
0.58	GO:0005372	water transmembrane transporter activity
0.54	GO:0005350	pyrimidine nucleobase transmembrane transporter activity
0.43	GO:0015168	glycerol transmembrane transporter activity
0.41	GO:0015204	urea transmembrane transporter activity
0.36	GO:0015105	arsenite transmembrane transporter activity
0.34	GO:0005275	amine transmembrane transporter activity
0.34	GO:0005515	protein binding
0.34	GO:0046943	carboxylic acid transmembrane transporter activity

0.43	GO:0043231	intracellular membrane-bounded organelle
0.37	GO:0016323	basolateral plasma membrane
0.35	GO:0046930	pore complex
0.35	GO:0005887	integral component of plasma membrane

0.34

GO:0004012

sp|O43316|PAX4_HUMAN
Paired box protein Pax-4
Search

PAX4

0.97	Paired box protein Pax-4

0.71	GO:0031016	pancreas development
0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.55	GO:0045597	positive regulation of cell differentiation
0.52	GO:0051253	negative regulation of RNA metabolic process
0.52	GO:0010558	negative regulation of macromolecule biosynthetic process
0.52	GO:0031327	negative regulation of cellular biosynthetic process
0.48	GO:0035270	endocrine system development

0.63	GO:0043565	sequence-specific DNA binding
0.58	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
0.55	GO:0035326	enhancer binding
0.55	GO:0001012	RNA polymerase II regulatory region DNA binding
0.52	GO:0003690	double-stranded DNA binding
0.46	GO:0070410	co-SMAD binding
0.46	GO:0071837	HMG box domain binding
0.45	GO:0070412	R-SMAD binding
0.45	GO:0035035	histone acetyltransferase binding
0.44	GO:0001047	core promoter binding

0.61	GO:0005634	nucleus
0.41	GO:0070013	intracellular organelle lumen
0.41	GO:0000785	chromatin
0.40	GO:0005829	cytosol
0.35	GO:0005667	transcription factor complex
0.30	GO:0016020	membrane

0.34

GO:0004842

sp|O43318|M3K7_HUMAN
Mitogen-activated protein kinase kinase kinase 7
Search

MAP3K7

0.94	Mitogen-activated protein kinase kinase kinase 7

0.84	GO:0000186	activation of MAPKK activity
0.79	GO:0000165	MAPK cascade
0.67	GO:0007252	I-kappaB phosphorylation
0.66	GO:0043507	positive regulation of JUN kinase activity
0.59	GO:0002726	positive regulation of T cell cytokine production
0.58	GO:0007250	activation of NF-kappaB-inducing kinase activity
0.58	GO:0032743	positive regulation of interleukin-2 production
0.56	GO:0043966	histone H3 acetylation
0.56	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.56	GO:0000187	activation of MAPK activity

0.84	GO:0004709	MAP kinase kinase kinase activity
0.64	GO:0000287	magnesium ion binding
0.57	GO:0097110	scaffold protein binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0032553	ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0042802	identical protein binding
0.36	GO:0004708	MAP kinase kinase activity

0.59	GO:0008385	IkappaB kinase complex
0.56	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
0.45	GO:0005886	plasma membrane
0.35	GO:0014069	postsynaptic density
0.35	GO:0010008	endosome membrane

0.84

EC:2.7.11 EC:2.7.11.25

GO:0004709

sp|O43320|FGF16_HUMAN
Fibroblast growth factor 16
Search

FGF16

0.62	Fibroblast growth factor

0.84	GO:0008543	fibroblast growth factor receptor signaling pathway
0.75	GO:0010469	regulation of receptor activity
0.59	GO:0090287	regulation of cellular response to growth factor stimulus
0.57	GO:2001028	positive regulation of endothelial cell chemotaxis
0.53	GO:1904707	positive regulation of vascular smooth muscle cell proliferation
0.52	GO:0035107	appendage morphogenesis
0.52	GO:0048513	animal organ development
0.51	GO:0032927	positive regulation of activin receptor signaling pathway
0.51	GO:0046546	development of primary male sexual characteristics
0.51	GO:0048505	regulation of timing of cell differentiation

0.85	GO:0005104	fibroblast growth factor receptor binding
0.78	GO:0008083	growth factor activity
0.39	GO:0008201	heparin binding
0.37	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.36	GO:0016303	1-phosphatidylinositol-3-kinase activity
0.36	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.36	GO:0004713	protein tyrosine kinase activity

0.66	GO:0005576	extracellular region
0.36	GO:0031982	vesicle
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.37	EC:2.7.1.153	GO:0046934
0.37	KEGG:R04545	GO:0046934

sp|O43323|DHH_HUMAN
Desert hedgehog protein
Search

0.82	Desert hedgehog protein A

0.74	GO:0007267	cell-cell signaling
0.73	GO:0016539	intein-mediated protein splicing
0.69	GO:0007275	multicellular organism development
0.65	GO:0001649	osteoblast differentiation
0.64	GO:0007224	smoothened signaling pathway
0.59	GO:0007281	germ cell development
0.57	GO:0050810	regulation of steroid biosynthetic process
0.56	GO:0007530	sex determination
0.56	GO:0048515	spermatid differentiation
0.55	GO:0007548	sex differentiation

0.67	GO:0005113	patched binding
0.60	GO:0008233	peptidase activity
0.54	GO:0005509	calcium ion binding
0.46	GO:0008270	zinc ion binding
0.37	GO:0042800	histone methyltransferase activity (H3-K4 specific)
0.37	GO:0003856	3-dehydroquinate synthase activity
0.35	GO:0043237	laminin-1 binding
0.35	GO:0003924	GTPase activity
0.35	GO:0005525	GTP binding
0.34	GO:0005539	glycosaminoglycan binding

0.67	GO:0005615	extracellular space
0.52	GO:0005886	plasma membrane
0.46	GO:0005578	proteinaceous extracellular matrix
0.36	GO:0035097	histone methyltransferase complex
0.34	GO:0008021	synaptic vesicle
0.34	GO:0043025	neuronal cell body
0.34	GO:0030425	dendrite
0.34	GO:0098857	membrane microdomain
0.34	GO:0030424	axon
0.34	GO:0009986	cell surface

0.60	EC:3.4	GO:0008233
0.37	KEGG:R03083	GO:0003856

sp|O43324|MCA3_HUMAN
Eukaryotic translation elongation factor 1 epsilon-1
Search

EEF1E1

0.96	Eukaryotic translation elongation factor 1 epsilon 1

0.62	GO:0006414	translational elongation
0.62	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
0.58	GO:1990830	cellular response to leukemia inhibitory factor
0.58	GO:2001235	positive regulation of apoptotic signaling pathway
0.56	GO:0008285	negative regulation of cell proliferation
0.48	GO:0006749	glutathione metabolic process
0.45	GO:2000774	positive regulation of cellular senescence
0.34	GO:0006418	tRNA aminoacylation for protein translation

0.63	GO:0003746	translation elongation factor activity
0.49	GO:0004364	glutathione transferase activity
0.35	GO:0005515	protein binding

0.61	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex
0.47	GO:0005634	nucleus
0.41	GO:0005737	cytoplasm
0.40	GO:0043233	organelle lumen
0.38	GO:0070062	extracellular exosome
0.37	GO:0044446	intracellular organelle part
0.37	GO:0043232	intracellular non-membrane-bounded organelle
0.33	GO:0097708	intracellular vesicle
0.33	GO:0012505	endomembrane system
0.30	GO:0031224	intrinsic component of membrane

0.49

EC:2.5.1.18

GO:0004364

sp|O43325|LYRM1_HUMAN
LYR motif-containing protein 1
Search

LYRM1

0.97	LYR motif-containing protein 1

0.81	GO:0030496	midbody
0.69	GO:0005654	nucleoplasm
0.61	GO:0005739	mitochondrion

sp|O43345|ZN208_HUMAN
Zinc finger protein 208
Search

0.64	Zinc finger protein 91

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.46	GO:0070895	negative regulation of transposon integration
0.44	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway
0.43	GO:1902679	negative regulation of RNA biosynthetic process
0.43	GO:0043508	negative regulation of JUN kinase activity
0.43	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
0.43	GO:0045671	negative regulation of osteoclast differentiation
0.42	GO:2000678	negative regulation of transcription regulatory region DNA binding

0.53	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.42	GO:0003700	DNA binding transcription factor activity
0.40	GO:0031625	ubiquitin protein ligase binding

0.45	GO:0005622	intracellular
0.41	GO:0043227	membrane-bounded organelle

sp|O43347|MSI1H_HUMAN
RNA-binding protein Musashi homolog 1
Search

MSI1

0.95	RNA-binding protein Musashi

0.42	GO:0007417	central nervous system development
0.35	GO:0030855	epithelial cell differentiation
0.34	GO:0050482	arachidonic acid secretion
0.34	GO:0009725	response to hormone
0.34	GO:0016042	lipid catabolic process
0.33	GO:0006644	phospholipid metabolic process

0.59	GO:0003723	RNA binding
0.50	GO:0042802	identical protein binding
0.34	GO:0004623	phospholipase A2 activity
0.33	GO:0005509	calcium ion binding

0.54	GO:0005844	polysome
0.44	GO:0005634	nucleus
0.39	GO:0005737	cytoplasm
0.33	GO:0005576	extracellular region
0.30	GO:0016020	membrane

0.34

EC:3.1.1.4

GO:0004623

sp|O43353|RIPK2_HUMAN
Receptor-interacting serine/threonine-protein kinase 2
Search

RIPK2

0.96	Receptor-interacting serine-threonine kinase 2

0.73	GO:0042981	regulation of apoptotic process
0.66	GO:0002250	adaptive immune response
0.65	GO:0010942	positive regulation of cell death
0.64	GO:0045087	innate immune response
0.64	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway
0.64	GO:0071225	cellular response to muramyl dipeptide
0.63	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway
0.63	GO:0006468	protein phosphorylation
0.62	GO:0071224	cellular response to peptidoglycan
0.62	GO:0097202	activation of cysteine-type endopeptidase activity

0.64	GO:0050700	CARD domain binding
0.64	GO:0004672	protein kinase activity
0.63	GO:0089720	caspase binding
0.61	GO:0030274	LIM domain binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0042803	protein homodimerization activity
0.54	GO:0097367	carbohydrate derivative binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0008144	drug binding
0.53	GO:0005102	receptor binding

0.53	GO:0031982	vesicle
0.51	GO:0005856	cytoskeleton
0.51	GO:0005829	cytosol
0.46	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

0.34	EC:4.1.3.40	GO:0008813
0.34	KEGG:R01302	GO:0008813

sp|O43361|ZN749_HUMAN
Zinc finger protein 749
Search

0.65	Zinc finger domain-containing protein (Fragment)

0.52	GO:1903506	regulation of nucleic acid-templated transcription
0.52	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.51	GO:0010468	regulation of gene expression
0.38	GO:0006351	transcription, DNA-templated
0.38	GO:1902679	negative regulation of RNA biosynthetic process
0.36	GO:1902466	positive regulation of histone H3-K27 trimethylation
0.36	GO:1900114	positive regulation of histone H3-K9 trimethylation
0.36	GO:0035562	negative regulation of chromatin binding
0.35	GO:2000811	negative regulation of anoikis
0.35	GO:0050679	positive regulation of epithelial cell proliferation

0.50	GO:0003676	nucleic acid binding
0.48	GO:0046872	metal ion binding
0.39	GO:0003700	DNA binding transcription factor activity
0.35	GO:1990841	promoter-specific chromatin binding
0.33	GO:0005515	protein binding

0.42	GO:0005622	intracellular
0.38	GO:0043227	membrane-bounded organelle

sp|O43364|HXA2_HUMAN
Homeobox protein Hox-A2
Search

HOXA2

0.77	Homeobox protein Hox-A2

0.67	GO:0007275	multicellular organism development
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.37	GO:0002076	osteoblast development
0.37	GO:0006351	transcription, DNA-templated
0.37	GO:0071300	cellular response to retinoic acid
0.37	GO:0045668	negative regulation of osteoblast differentiation
0.37	GO:0001709	cell fate determination
0.37	GO:1904888	cranial skeletal system development

0.64	GO:0043565	sequence-specific DNA binding
0.59	GO:0003700	DNA binding transcription factor activity
0.36	GO:0001012	RNA polymerase II regulatory region DNA binding
0.35	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.33	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O43365|HXA3_HUMAN
Homeobox protein Hox-A3
Search

HOXA3

0.97	Homeobox protein Hox-A3

0.68	GO:0007275	multicellular organism development
0.56	GO:2001141	regulation of RNA biosynthetic process
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.55	GO:0001974	blood vessel remodeling
0.55	GO:0061448	connective tissue development
0.51	GO:0008284	positive regulation of cell proliferation
0.50	GO:0048646	anatomical structure formation involved in morphogenesis
0.48	GO:0002376	immune system process
0.39	GO:0007219	Notch signaling pathway

0.64	GO:0043565	sequence-specific DNA binding
0.60	GO:0003700	DNA binding transcription factor activity
0.56	GO:0071837	HMG box domain binding
0.38	GO:0001012	RNA polymerase II regulatory region DNA binding
0.37	GO:0003690	double-stranded DNA binding

0.61	GO:0005634	nucleus
0.47	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.40	GO:0016235	aggresome

sp|O43374|RASL2_HUMAN
Ras GTPase-activating protein 4
Search

0.93	Ras GTPase-activating protein 4

0.77	GO:0071277	cellular response to calcium ion
0.77	GO:0046580	negative regulation of Ras protein signal transduction
0.74	GO:0043087	regulation of GTPase activity
0.71	GO:0051345	positive regulation of hydrolase activity
0.60	GO:0007165	signal transduction
0.42	GO:1903861	positive regulation of dendrite extension
0.38	GO:0051346	negative regulation of hydrolase activity
0.37	GO:0006366	transcription by RNA polymerase II
0.35	GO:0006468	protein phosphorylation

0.73	GO:0005096	GTPase activator activity
0.69	GO:0005543	phospholipid binding
0.38	GO:0001055	RNA polymerase II activity
0.36	GO:0046983	protein dimerization activity
0.36	GO:0046872	metal ion binding
0.33	GO:0003677	DNA binding

0.47	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane
0.44	GO:0005622	intracellular
0.36	GO:0061695	transferase complex, transferring phosphorus-containing groups
0.36	GO:0031974	membrane-enclosed lumen
0.34	GO:0044422	organelle part
0.34	GO:0043227	membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

sp|O43379|WDR62_HUMAN
WD repeat-containing protein 62
Search

WDR62

0.96	WD repeat-containing protein 62

0.84	GO:0021987	cerebral cortex development
0.83	GO:0007099	centriole replication
0.82	GO:0007052	mitotic spindle organization
0.74	GO:0022008	neurogenesis
0.56	GO:0008380	RNA splicing
0.48	GO:2000648	positive regulation of stem cell proliferation
0.48	GO:2000179	positive regulation of neural precursor cell proliferation
0.47	GO:0046605	regulation of centrosome cycle
0.46	GO:0030335	positive regulation of cell migration
0.46	GO:0010720	positive regulation of cell development

0.47	GO:0003723	RNA binding
0.38	GO:0005515	protein binding
0.30	GO:0003824	catalytic activity

0.78	GO:0000922	spindle pole
0.76	GO:0005813	centrosome
0.65	GO:0005829	cytosol
0.63	GO:0071011	precatalytic spliceosome
0.62	GO:0005682	U5 snRNP
0.61	GO:0071013	catalytic step 2 spliceosome
0.49	GO:0005814	centriole

sp|O43390|HNRPR_HUMAN
Heterogeneous nuclear ribonucleoprotein R
Search

HNRNPR

0.93	Heterogeneous nuclear ribonucleoprotein R

0.44	GO:1902284	neuron projection extension involved in neuron projection guidance
0.44	GO:0048675	axon extension
0.42	GO:0007411	axon guidance
0.40	GO:0061157	mRNA destabilization
0.39	GO:0007623	circadian rhythm
0.38	GO:0043086	negative regulation of catalytic activity
0.34	GO:0000398	mRNA splicing, via spliceosome

0.58	GO:0003723	RNA binding
0.33	GO:0005515	protein binding

0.64	GO:0019013	viral nucleocapsid
0.57	GO:0030529	intracellular ribonucleoprotein complex
0.47	GO:0005654	nucleoplasm
0.43	GO:1902494	catalytic complex
0.40	GO:0043679	axon terminus
0.40	GO:0030426	growth cone
0.39	GO:0030425	dendrite
0.37	GO:0005730	nucleolus
0.34	GO:0005783	endoplasmic reticulum

sp|O43395|PRPF3_HUMAN
U4/U6 small nuclear ribonucleoprotein Prp3
Search

PRPF3

0.84	Pre-mRNA processing factor 3

0.75	GO:0000398	mRNA splicing, via spliceosome
0.59	GO:0022618	ribonucleoprotein complex assembly
0.53	GO:0060041	retina development in camera-type eye

0.59	GO:0042802	identical protein binding
0.36	GO:0003723	RNA binding

0.81	GO:0046540	U4/U6 x U5 tri-snRNP complex
0.67	GO:0015030	Cajal body
0.62	GO:0016607	nuclear speck
0.55	GO:0005829	cytosol
0.39	GO:0019013	viral nucleocapsid
0.36	GO:0043234	protein complex

sp|O43396|TXNL1_HUMAN
Thioredoxin-like protein 1
Search

TXNL1

0.91	Z-linked thioredoxin like 1

0.66	GO:0045454	cell redox homeostasis
0.44	GO:0034599	cellular response to oxidative stress
0.42	GO:0098869	cellular oxidant detoxification
0.41	GO:0055114	oxidation-reduction process
0.37	GO:0006662	glycerol ether metabolic process

0.51	GO:0015036	disulfide oxidoreductase activity
0.44	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
0.44	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
0.42	GO:0016209	antioxidant activity

0.48	GO:0005829	cytosol
0.37	GO:1905369	endopeptidase complex
0.37	GO:0070062	extracellular exosome
0.35	GO:0005634	nucleus
0.35	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

0.44

EC:1.8.4

GO:0016671

sp|O43399|TPD54_HUMAN
Tumor protein D54
Search

TPD52L2

0.91	Tumor protein D52 like 2

0.54

GO:0042127

regulation of cell proliferation

0.69	GO:0042803	protein homodimerization activity
0.68	GO:0046982	protein heterodimerization activity
0.51	GO:0003723	RNA binding

0.79

GO:0048471

perinuclear region of cytoplasm

sp|O43402|EMC8_HUMAN
ER membrane protein complex subunit 8
Search

EMC8

0.93	ER membrane protein complex subunit 8

0.36

GO:0005515

protein binding

0.84	GO:0072546	ER membrane protein complex
0.66	GO:0005829	cytosol
0.59	GO:0005739	mitochondrion
0.36	GO:0005634	nucleus

sp|O43405|COCH_HUMAN
Cochlin
Search

COCH

0.75	Coagulation factor C homolog, cochlin (Limulus polyphemus)

0.63	GO:0007605	sensory perception of sound
0.62	GO:0045089	positive regulation of innate immune response
0.60	GO:0042742	defense response to bacterium
0.41	GO:0010811	positive regulation of cell-substrate adhesion
0.41	GO:0030198	extracellular matrix organization
0.36	GO:0006904	vesicle docking involved in exocytosis
0.36	GO:0008360	regulation of cell shape
0.35	GO:0018298	protein-chromophore linkage
0.34	GO:0007186	G-protein coupled receptor signaling pathway
0.33	GO:0007229	integrin-mediated signaling pathway

0.40	GO:0005539	glycosaminoglycan binding
0.38	GO:0005518	collagen binding
0.35	GO:0009881	photoreceptor activity
0.35	GO:0004930	G-protein coupled receptor activity
0.32	GO:0005509	calcium ion binding

0.74	GO:0031012	extracellular matrix
0.33	GO:0005581	collagen trimer
0.33	GO:0008305	integrin complex
0.30	GO:0043230	extracellular organelle
0.30	GO:0031982	vesicle
0.30	GO:0005615	extracellular space

sp|O43414|ERI3_HUMAN
ERI1 exoribonuclease 3
Search

ERI3

0.97	Prion protein-interacting protein (Fragment)

0.40	GO:0006259	DNA metabolic process
0.37	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.34	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation
0.33	GO:0032366	intracellular sterol transport
0.32	GO:0050790	regulation of catalytic activity

0.51	GO:0003676	nucleic acid binding
0.38	GO:0004527	exonuclease activity
0.34	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding
0.32	GO:0016772	transferase activity, transferring phosphorus-containing groups
0.32	GO:0030234	enzyme regulator activity

0.33	GO:1905369	endopeptidase complex
0.33	GO:0005886	plasma membrane
0.32	GO:0043234	protein complex
0.32	GO:0005622	intracellular

0.32

GO:0016772

sp|O43422|P52K_HUMAN
52 kDa repressor of the inhibitor of the protein kinase
Search

THAP12

0.94	Repressor of the inhibitor of the protein kinase

0.49	GO:0016310	phosphorylation
0.44	GO:0006357	regulation of transcription by RNA polymerase II
0.35	GO:0008285	negative regulation of cell proliferation
0.33	GO:0007165	signal transduction
0.32	GO:0018212	peptidyl-tyrosine modification

0.63	GO:0046983	protein dimerization activity
0.53	GO:0003677	DNA binding
0.51	GO:0016301	kinase activity
0.45	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.33	GO:0046872	metal ion binding
0.32	GO:0004888	transmembrane signaling receptor activity
0.31	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.31	GO:0140096	catalytic activity, acting on a protein
0.31	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding

0.44	GO:0005634	nucleus
0.43	GO:0031974	membrane-enclosed lumen
0.39	GO:0044446	intracellular organelle part
0.37	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.31

GO:0016773

sp|O43423|AN32C_HUMAN
Acidic leucine-rich nuclear phosphoprotein 32 family member C
Search

ANP32A

0.90	Acidic leucine-rich nuclear phosphoprotein 32 family member C

0.70	GO:0006913	nucleocytoplasmic transport
0.69	GO:0043486	histone exchange
0.63	GO:0006334	nucleosome assembly
0.60	GO:0042981	regulation of apoptotic process
0.45	GO:0006351	transcription, DNA-templated
0.44	GO:1903506	regulation of nucleic acid-templated transcription
0.44	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.44	GO:0010468	regulation of gene expression
0.43	GO:0035067	negative regulation of histone acetylation
0.43	GO:0010977	negative regulation of neuron projection development

0.66	GO:0042393	histone binding
0.44	GO:0019212	phosphatase inhibitor activity
0.43	GO:0005178	integrin binding
0.42	GO:0008022	protein C-terminus binding
0.40	GO:0003723	RNA binding

0.74	GO:0048471	perinuclear region of cytoplasm
0.66	GO:0005783	endoplasmic reticulum
0.61	GO:0005634	nucleus
0.51	GO:0031974	membrane-enclosed lumen
0.46	GO:0044446	intracellular organelle part
0.41	GO:0031410	cytoplasmic vesicle
0.40	GO:0005694	chromosome
0.40	GO:1904949	ATPase complex
0.39	GO:0005829	cytosol

sp|O43424|GRID2_HUMAN
Glutamate receptor ionotropic, delta-2
Search

GRID2

0.89	Glutamate ionotropic receptor delta type subunit 2

0.76	GO:0060079	excitatory postsynaptic potential
0.74	GO:0035235	ionotropic glutamate receptor signaling pathway
0.59	GO:1900454	positive regulation of long term synaptic depression
0.58	GO:1904861	excitatory synapse assembly
0.58	GO:0034220	ion transmembrane transport
0.57	GO:0021684	cerebellar granular layer formation
0.57	GO:0060134	prepulse inhibition
0.56	GO:0021533	cell differentiation in hindbrain
0.56	GO:0035249	synaptic transmission, glutamatergic
0.55	GO:0051965	positive regulation of synapse assembly

0.78	GO:0005234	extracellularly glutamate-gated ion channel activity
0.74	GO:0004970	ionotropic glutamate receptor activity
0.55	GO:0097110	scaffold protein binding
0.55	GO:0030165	PDZ domain binding
0.35	GO:0042802	identical protein binding
0.32	GO:0003735	structural constituent of ribosome

0.74	GO:0098794	postsynapse
0.74	GO:0097060	synaptic membrane
0.70	GO:0030054	cell junction
0.55	GO:0008328	ionotropic glutamate receptor complex
0.55	GO:0044309	neuron spine
0.53	GO:0030425	dendrite
0.36	GO:0032279	asymmetric synapse
0.33	GO:0043226	organelle
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0044444	cytoplasmic part

sp|O43426|SYNJ1_HUMAN
Synaptojanin-1
Search

SYNJ1

0.91	LOW QUALITY PROTEIN: synaptojanin-1

0.85	GO:0048488	synaptic vesicle endocytosis
0.81	GO:0046856	phosphatidylinositol dephosphorylation
0.41	GO:1904980	positive regulation of endosome organization
0.40	GO:0051650	establishment of vesicle localization
0.40	GO:0072318	clathrin coat disassembly
0.40	GO:0007268	chemical synaptic transmission
0.39	GO:0048699	generation of neurons
0.39	GO:0048260	positive regulation of receptor-mediated endocytosis
0.39	GO:0048513	animal organ development
0.39	GO:0032526	response to retinoic acid

0.85	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity
0.56	GO:0003723	RNA binding
0.42	GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity
0.40	GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity
0.39	GO:0004438	phosphatidylinositol-3-phosphatase activity
0.38	GO:0008022	protein C-terminus binding
0.38	GO:0017124	SH3 domain binding
0.37	GO:0032403	protein complex binding
0.36	GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
0.36	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity

0.76	GO:0045202	synapse
0.41	GO:0030132	clathrin coat of coated pit
0.40	GO:0043005	neuron projection
0.40	GO:0098590	plasma membrane region
0.39	GO:0005874	microtubule
0.39	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0012506	vesicle membrane
0.37	GO:0120038	plasma membrane bounded cell projection part
0.34	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.39	EC:3.1.3.64	GO:0004438
0.36	KEGG:R03430	GO:0052659

sp|O43427|FIBP_HUMAN
Acidic fibroblast growth factor intracellular-binding protein
Search

FIBP

0.95	Acidic fibroblast growth factor intracellular-binding protein B

0.39	GO:0070527	platelet aggregation
0.37	GO:0048251	elastic fiber assembly
0.35	GO:0008543	fibroblast growth factor receptor signaling pathway
0.35	GO:0070121	Kupffer's vesicle development
0.35	GO:0060026	convergent extension
0.34	GO:0007368	determination of left/right symmetry
0.34	GO:0060271	cilium assembly
0.34	GO:0006357	regulation of transcription by RNA polymerase II

0.85	GO:0017134	fibroblast growth factor binding
0.35	GO:0005509	calcium ion binding
0.33	GO:0003700	DNA binding transcription factor activity
0.32	GO:0003677	DNA binding

0.53	GO:0016607	nuclear speck
0.38	GO:0005615	extracellular space
0.38	GO:1903561	extracellular vesicle
0.37	GO:0012505	endomembrane system
0.33	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

sp|O43432|IF4G3_HUMAN
Eukaryotic translation initiation factor 4 gamma 3
Search

EIF4G3

0.90	Eukaryotic translation initiation factor 4 gamma 3

0.72	GO:0006413	translational initiation
0.37	GO:0060903	positive regulation of meiosis I
0.37	GO:0006417	regulation of translation
0.36	GO:0007283	spermatogenesis
0.36	GO:0034250	positive regulation of cellular amide metabolic process
0.36	GO:0010507	negative regulation of autophagy
0.36	GO:0001934	positive regulation of protein phosphorylation
0.35	GO:0010557	positive regulation of macromolecule biosynthetic process
0.35	GO:0031328	positive regulation of cellular biosynthetic process
0.35	GO:0010628	positive regulation of gene expression

0.83	GO:0000339	RNA cap binding
0.72	GO:0003743	translation initiation factor activity
0.35	GO:0005515	protein binding

0.37	GO:0016281	eukaryotic translation initiation factor 4F complex
0.34	GO:0005829	cytosol

sp|O43435|TBX1_HUMAN
T-box transcription factor TBX1
Search

TBX1

0.93	T-box transcription factor

0.58	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:0060017	parathyroid gland development
0.51	GO:0060023	soft palate development
0.51	GO:0060037	pharyngeal system development
0.50	GO:0048538	thymus development
0.50	GO:0048703	embryonic viscerocranium morphogenesis
0.48	GO:0007507	heart development

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.46	GO:0042803	protein homodimerization activity
0.36	GO:0001067	regulatory region nucleic acid binding
0.33	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.33	GO:0016787	hydrolase activity
0.33	GO:0005525	GTP binding

0.61	GO:0005634	nucleus
0.34	GO:0008021	synaptic vesicle
0.30	GO:0016020	membrane

0.33

EC:1.2.1

GO:0016620

sp|O43439|MTG8R_HUMAN
Protein CBFA2T2
Search

CBFA2T2

0.97	Core-binding factor, runt domain, alpha subunit 2 translocated to, 2

0.72	GO:0045892	negative regulation of transcription, DNA-templated
0.54	GO:0060575	intestinal epithelial cell differentiation
0.53	GO:0045746	negative regulation of Notch signaling pathway
0.53	GO:0010976	positive regulation of neuron projection development
0.46	GO:0006357	regulation of transcription by RNA polymerase II
0.38	GO:0010977	negative regulation of neuron projection development
0.34	GO:0006351	transcription, DNA-templated

0.81	GO:0003714	transcription corepressor activity
0.61	GO:0003700	DNA binding transcription factor activity
0.34	GO:0005515	protein binding
0.34	GO:0046872	metal ion binding
0.31	GO:0003677	DNA binding

0.45

GO:0005634

nucleus

sp|O43447|PPIH_HUMAN
Peptidyl-prolyl cis-trans isomerase H
Search

PPIH

0.49	Peptidyl-prolyl cis-trans isomerase H

0.72	GO:0000413	protein peptidyl-prolyl isomerization
0.68	GO:0006457	protein folding
0.53	GO:0045070	positive regulation of viral genome replication
0.44	GO:0001525	angiogenesis
0.36	GO:0008380	RNA splicing
0.36	GO:0006397	mRNA processing
0.34	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression
0.33	GO:0006461	protein complex assembly

0.72	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.47	GO:0043021	ribonucleoprotein complex binding
0.35	GO:0016018	cyclosporin A binding
0.33	GO:0003677	DNA binding
0.33	GO:0005515	protein binding

0.54	GO:0071001	U4/U6 snRNP
0.50	GO:0046540	U4/U6 x U5 tri-snRNP complex
0.50	GO:0016607	nuclear speck
0.38	GO:0005737	cytoplasm
0.36	GO:0005681	spliceosomal complex
0.30	GO:0031224	intrinsic component of membrane

0.72

GO:0003755

sp|O43448|KCAB3_HUMAN
Voltage-gated potassium channel subunit beta-3
Search

KCNAB3

0.94	Voltage-gated potassium channel subunit beta-3

0.73	GO:0071805	potassium ion transmembrane transport
0.47	GO:1903817	negative regulation of voltage-gated potassium channel activity
0.45	GO:0007611	learning or memory
0.41	GO:1902259	regulation of delayed rectifier potassium channel activity
0.38	GO:0060539	diaphragm development
0.37	GO:0045445	myoblast differentiation
0.37	GO:0007519	skeletal muscle tissue development
0.36	GO:0007507	heart development
0.36	GO:0007420	brain development
0.35	GO:0055114	oxidation-reduction process

0.77	GO:0005249	voltage-gated potassium channel activity
0.49	GO:0015459	potassium channel regulator activity
0.45	GO:0070402	NADPH binding
0.43	GO:0019904	protein domain specific binding
0.40	GO:0004033	aldo-keto reductase (NADP) activity
0.37	GO:0044325	ion channel binding

0.49	GO:0005737	cytoplasm
0.45	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.45	GO:0034705	potassium channel complex
0.41	GO:0005887	integral component of plasma membrane
0.39	GO:0044224	juxtaparanode region of axon
0.38	GO:1990635	proximal dendrite
0.37	GO:0043204	perikaryon
0.34	GO:0030008	TRAPP complex
0.34	GO:0043679	axon terminus
0.34	GO:0014069	postsynaptic density

0.40

EC:1.1.1

GO:0004033

sp|O43451|MGA_HUMAN
Maltase-glucoamylase, intestinal
Search

MGAM

0.79	Maltase-glucoamylase

0.60	GO:0005975	carbohydrate metabolic process
0.46	GO:0044245	polysaccharide digestion
0.44	GO:0043312	neutrophil degranulation
0.39	GO:0009057	macromolecule catabolic process
0.38	GO:0044248	cellular catabolic process
0.35	GO:0044260	cellular macromolecule metabolic process

0.69	GO:0030246	carbohydrate binding
0.66	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds

0.45	GO:0101003	ficolin-1-rich granule membrane
0.44	GO:0070821	tertiary granule membrane
0.42	GO:0016324	apical plasma membrane
0.42	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.66

EC:3.2.1

GO:0004553

sp|O43462|MBTP2_HUMAN
Membrane-bound transcription factor site-2 protease
Search

MBTPS2

0.95	Membrane-bound transcription factor site-2 protease

0.65	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
0.63	GO:0031293	membrane protein intracellular domain proteolysis
0.60	GO:0051091	positive regulation of DNA binding transcription factor activity
0.51	GO:0036500	ATF6-mediated unfolded protein response
0.42	GO:0051216	cartilage development
0.42	GO:0008203	cholesterol metabolic process
0.36	GO:0045540	regulation of cholesterol biosynthetic process

0.68	GO:0004222	metalloendopeptidase activity
0.36	GO:0046872	metal ion binding
0.32	GO:0003676	nucleic acid binding

0.41	GO:0005737	cytoplasm
0.36	GO:0098588	bounding membrane of organelle
0.36	GO:0031984	organelle subcompartment
0.36	GO:0012505	endomembrane system
0.34	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

0.68

GO:0004222

sp|O43463|SUV91_HUMAN
Histone-lysine N-methyltransferase SUV39H1
Search

SUV39H1

0.52	Histone-lysine N-methyltransferase

0.79	GO:0034968	histone lysine methylation
0.65	GO:0061647	histone H3-K9 modification
0.60	GO:0071456	cellular response to hypoxia
0.56	GO:0000122	negative regulation of transcription by RNA polymerase II
0.55	GO:0000183	chromatin silencing at rDNA
0.45	GO:0006974	cellular response to DNA damage stimulus
0.45	GO:0006333	chromatin assembly or disassembly
0.45	GO:0006338	chromatin remodeling
0.44	GO:0042754	negative regulation of circadian rhythm
0.43	GO:0032502	developmental process

0.79	GO:0018024	histone-lysine N-methyltransferase activity
0.62	GO:0008270	zinc ion binding
0.55	GO:0047485	protein N-terminus binding
0.45	GO:1904047	S-adenosyl-L-methionine binding
0.41	GO:0000976	transcription regulatory region sequence-specific DNA binding
0.37	GO:0001012	RNA polymerase II regulatory region DNA binding
0.37	GO:0003682	chromatin binding

0.65	GO:0005694	chromosome
0.61	GO:0005634	nucleus
0.53	GO:0017053	transcriptional repressor complex
0.48	GO:0031974	membrane-enclosed lumen
0.46	GO:0044446	intracellular organelle part

0.79

EC:2.1.1.43

GO:0018024

sp|O43464|HTRA2_HUMAN
Serine protease HTRA2, mitochondrial
Search

HTRA2

0.86	HtrA serine peptidase 2

0.63	GO:1904924	negative regulation of mitophagy in response to mitochondrial depolarization
0.61	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
0.61	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
0.61	GO:0006508	proteolysis
0.61	GO:0035458	cellular response to interferon-beta
0.60	GO:0070207	protein homotrimerization
0.59	GO:0071300	cellular response to retinoic acid
0.59	GO:0007628	adult walking behavior
0.59	GO:1903955	positive regulation of protein targeting to mitochondrion
0.58	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage

0.69	GO:0004252	serine-type endopeptidase activity
0.52	GO:0042802	identical protein binding
0.43	GO:0005520	insulin-like growth factor binding
0.35	GO:0051082	unfolded protein binding
0.34	GO:0005044	scavenger receptor activity
0.34	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
0.33	GO:0005507	copper ion binding

0.63	GO:1905370	serine-type endopeptidase complex
0.61	GO:0035631	CD40 receptor complex
0.55	GO:0005758	mitochondrial intermembrane space
0.53	GO:0009898	cytoplasmic side of plasma membrane
0.52	GO:0000785	chromatin
0.50	GO:0005856	cytoskeleton
0.50	GO:0005829	cytosol
0.46	GO:0005634	nucleus
0.39	GO:0005576	extracellular region
0.36	GO:0031966	mitochondrial membrane

0.69

GO:0004252

sp|O43474|KLF4_HUMAN
Krueppel-like factor 4
Search

KLF4

0.93	Kruppel like factor 4

0.60	GO:0071499	cellular response to laminar fluid shear stress
0.60	GO:1904998	negative regulation of leukocyte adhesion to arterial endothelial cell
0.60	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production
0.59	GO:0046985	positive regulation of hemoglobin biosynthetic process
0.59	GO:0045415	negative regulation of interleukin-8 biosynthetic process
0.58	GO:0045429	positive regulation of nitric oxide biosynthetic process
0.58	GO:0061614	pri-miRNA transcription by RNA polymerase II
0.58	GO:0034115	negative regulation of heterotypic cell-cell adhesion
0.57	GO:0031077	post-embryonic camera-type eye development
0.57	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis

0.57	GO:0001010	transcription factor activity, sequence-specific DNA binding transcription factor recruiting
0.56	GO:1990841	promoter-specific chromatin binding
0.55	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
0.54	GO:0001085	RNA polymerase II transcription factor binding
0.54	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.53	GO:0008013	beta-catenin binding
0.53	GO:0001047	core promoter binding
0.52	GO:0000987	proximal promoter sequence-specific DNA binding
0.43	GO:0001221	transcription cofactor binding
0.43	GO:0035014	phosphatidylinositol 3-kinase regulator activity

0.54	GO:0005719	nuclear euchromatin
0.50	GO:0044798	nuclear transcription factor complex
0.49	GO:0005654	nucleoplasm
0.38	GO:0005737	cytoplasm

sp|O43482|MS18B_HUMAN
Protein Mis18-beta
Search

OIP5

0.97	Opa interacting protein 5

0.64	GO:0034080	CENP-A containing nucleosome assembly
0.54	GO:0007059	chromosome segregation

0.69	GO:0042802	identical protein binding
0.54	GO:0046872	metal ion binding

0.84	GO:0010369	chromocenter
0.80	GO:0015030	Cajal body
0.77	GO:0016607	nuclear speck
0.69	GO:0000785	chromatin
0.66	GO:0005829	cytosol
0.57	GO:0000775	chromosome, centromeric region

sp|O43488|ARK72_HUMAN
Aflatoxin B1 aldehyde reductase member 2
Search

AKR7A2

0.84	Aflatoxin aldehyde reductase

0.54	GO:0044598	doxorubicin metabolic process
0.54	GO:0044597	daunorubicin metabolic process
0.49	GO:0055114	oxidation-reduction process
0.40	GO:0006805	xenobiotic metabolic process
0.38	GO:0046223	aflatoxin catabolic process
0.37	GO:0006081	cellular aldehyde metabolic process
0.36	GO:0006091	generation of precursor metabolites and energy
0.34	GO:0005975	carbohydrate metabolic process

0.56	GO:0019119	phenanthrene-9,10-epoxide hydrolase activity
0.50	GO:0016491	oxidoreductase activity
0.39	GO:0042802	identical protein binding

0.47	GO:0005829	cytosol
0.45	GO:0005739	mitochondrion
0.44	GO:0070062	extracellular exosome
0.39	GO:0005794	Golgi apparatus
0.35	GO:0031984	organelle subcompartment

0.56

EC:3.3.2

GO:0019119

sp|O43490|PROM1_HUMAN
Prominin-1
Search

PROM1

0.94	Prominin-1-A

0.63	GO:0072139	glomerular parietal epithelial cell differentiation
0.63	GO:2000768	positive regulation of nephron tubule epithelial cell differentiation
0.60	GO:0072112	glomerular visceral epithelial cell differentiation
0.60	GO:0060219	camera-type eye photoreceptor cell differentiation
0.59	GO:0045494	photoreceptor cell maintenance
0.43	GO:0010842	retina layer formation

0.57	GO:0042805	actinin binding
0.57	GO:0045296	cadherin binding

0.61	GO:0042622	photoreceptor outer segment membrane
0.58	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.56	GO:0070062	extracellular exosome
0.53	GO:0009986	cell surface
0.51	GO:0005783	endoplasmic reticulum
0.43	GO:0071914	prominosome
0.43	GO:0016324	apical plasma membrane
0.42	GO:0005902	microvillus
0.41	GO:0032420	stereocilium
0.41	GO:0005903	brush border

sp|O43491|E41L2_HUMAN
Band 4.1-like protein 2
Search

EPB41L2

0.96	Erythrocyte membrane protein band 4.1 like 2

0.79	GO:0030866	cortical actin cytoskeleton organization
0.63	GO:1904778	positive regulation of protein localization to cell cortex
0.49	GO:0031032	actomyosin structure organization
0.36	GO:0051301	cell division
0.36	GO:0007049	cell cycle
0.34	GO:0008360	regulation of cell shape

0.71	GO:0003779	actin binding
0.61	GO:0042731	PH domain binding
0.60	GO:0005198	structural molecule activity
0.58	GO:0030507	spectrin binding

0.68	GO:0005856	cytoskeleton
0.58	GO:0099738	cell cortex region
0.57	GO:0008180	COP9 signalosome
0.54	GO:0030054	cell junction
0.51	GO:0005654	nucleoplasm
0.45	GO:0005886	plasma membrane
0.38	GO:0070062	extracellular exosome
0.35	GO:0005829	cytosol

sp|O43493|TGON2_HUMAN
Trans-Golgi network integral membrane protein 2
Search

TGOLN2

0.96	Trans-Golgi network integral membrane protein 2

0.54	GO:0006895	Golgi to endosome transport
0.40	GO:0043687	post-translational protein modification
0.39	GO:0043547	positive regulation of GTPase activity
0.37	GO:0061024	membrane organization
0.36	GO:0060070	canonical Wnt signaling pathway
0.35	GO:0006357	regulation of transcription by RNA polymerase II
0.33	GO:0009405	pathogenesis
0.32	GO:0009254	peptidoglycan turnover

0.39	GO:0005096	GTPase activator activity
0.38	GO:0005515	protein binding
0.33	GO:0003677	DNA binding
0.33	GO:0004872	receptor activity
0.32	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds

0.78	GO:0005802	trans-Golgi network
0.52	GO:0030140	trans-Golgi network transport vesicle
0.50	GO:0005654	nucleoplasm
0.50	GO:0005768	endosome
0.46	GO:0005829	cytosol
0.40	GO:0005788	endoplasmic reticulum lumen
0.40	GO:0030665	clathrin-coated vesicle membrane
0.36	GO:0005886	plasma membrane
0.32	GO:0019867	outer membrane
0.30	GO:0016021	integral component of membrane

0.32

EC:3.2.1

GO:0004553

sp|O43497|CAC1G_HUMAN
Voltage-dependent T-type calcium channel subunit alpha-1G
Search

CACNA1G

0.82	Voltage-dependent T-type calcium channel subunit alpha

0.85	GO:0070509	calcium ion import
0.77	GO:0070588	calcium ion transmembrane transport
0.72	GO:0034765	regulation of ion transmembrane transport
0.66	GO:0086046	membrane depolarization during SA node cell action potential
0.66	GO:0086045	membrane depolarization during AV node cell action potential
0.65	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
0.63	GO:0086002	cardiac muscle cell action potential involved in contraction
0.63	GO:0086091	regulation of heart rate by cardiac conduction
0.61	GO:0010045	response to nickel cation
0.57	GO:0007268	chemical synaptic transmission

0.86	GO:0008332	low voltage-gated calcium channel activity
0.66	GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential
0.66	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential
0.63	GO:0097110	scaffold protein binding
0.52	GO:0005248	voltage-gated sodium channel activity
0.34	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.81	GO:0005891	voltage-gated calcium channel complex
0.41	GO:0005737	cytoplasm
0.35	GO:0043025	neuronal cell body
0.35	GO:0030425	dendrite

sp|O43502|RA51C_HUMAN
DNA repair protein RAD51 homolog 3
Search

RAD51C

0.95	DNA repair protein RAD51 like protein 3

0.63	GO:0006281	DNA repair
0.63	GO:0007066	female meiosis sister chromatid cohesion
0.60	GO:0007141	male meiosis I
0.59	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
0.59	GO:0006312	mitotic recombination
0.57	GO:0007131	reciprocal meiotic recombination
0.55	GO:0007283	spermatogenesis
0.54	GO:0000723	telomere maintenance
0.50	GO:0042148	strand invasion
0.49	GO:0090735	DNA repair complex assembly

0.68	GO:0008094	DNA-dependent ATPase activity
0.60	GO:0000400	four-way junction DNA binding
0.56	GO:0008821	crossover junction endodeoxyribonuclease activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0000150	recombinase activity
0.44	GO:0003697	single-stranded DNA binding
0.44	GO:0003690	double-stranded DNA binding
0.35	GO:0005515	protein binding

0.63	GO:0033065	Rad51C-XRCC3 complex
0.60	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex
0.55	GO:0048471	perinuclear region of cytoplasm
0.55	GO:0048476	Holliday junction resolvase complex
0.53	GO:0030054	cell junction
0.53	GO:0005657	replication fork
0.50	GO:0005829	cytosol
0.46	GO:0005739	mitochondrion
0.34	GO:0005654	nucleoplasm

0.56

EC:3.1.22.4

GO:0008821

sp|O43504|LTOR5_HUMAN
Ragulator complex protein LAMTOR5
Search

LAMTOR5

0.97	Chain A, Of Hepatitis B X-Interacting Protein At High Resolution

0.85	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.70	GO:0019079	viral genome replication
0.44	GO:0061462	protein localization to lysosome
0.43	GO:0071230	cellular response to amino acid stimulus
0.42	GO:0008361	regulation of cell size
0.42	GO:0032008	positive regulation of TOR signaling
0.35	GO:0016241	regulation of macroautophagy
0.35	GO:0007050	cell cycle arrest
0.35	GO:0009615	response to virus
0.34	GO:0055085	transmembrane transport

0.42	GO:0032947	protein complex scaffold activity
0.41	GO:0005085	guanyl-nucleotide exchange factor activity
0.32	GO:0003735	structural constituent of ribosome

0.85	GO:0071986	Ragulator complex
0.46	GO:0005829	cytosol
0.42	GO:0005764	lysosome
0.35	GO:0098852	lytic vacuole membrane
0.32	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

sp|O43505|B4GA1_HUMAN
Beta-1,4-glucuronyltransferase 1
Search

B4GAT1

0.54	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

0.65	GO:0035269	protein O-linked mannosylation
0.61	GO:0007411	axon guidance
0.47	GO:0030311	poly-N-acetyllactosamine biosynthetic process
0.45	GO:0048747	muscle fiber development
0.38	GO:0018146	keratan sulfate biosynthetic process
0.34	GO:0007165	signal transduction

0.63	GO:0015020	glucuronosyltransferase activity
0.49	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
0.36	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.56	GO:0005794	Golgi apparatus
0.40	GO:0098588	bounding membrane of organelle
0.39	GO:0031984	organelle subcompartment
0.38	GO:0070062	extracellular exosome
0.36	GO:0031301	integral component of organelle membrane

0.63

EC:2.4.1.17

GO:0015020

sp|O43506|ADA20_HUMAN
Disintegrin and metalloproteinase domain-containing protein 20
Search

0.95	LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 20

0.61	GO:0006508	proteolysis
0.57	GO:0007229	integrin-mediated signaling pathway
0.41	GO:0007338	single fertilization
0.41	GO:0060467	negative regulation of fertilization
0.39	GO:0001775	cell activation
0.37	GO:0009988	cell-cell recognition
0.36	GO:0007283	spermatogenesis
0.35	GO:0030154	cell differentiation
0.35	GO:0007275	multicellular organism development
0.33	GO:0006865	amino acid transport

0.70	GO:0004222	metalloendopeptidase activity
0.53	GO:0046872	metal ion binding
0.37	GO:0005178	integrin binding
0.32	GO:0022857	transmembrane transporter activity

0.43	GO:0043025	neuronal cell body
0.42	GO:0030424	axon
0.38	GO:1990913	sperm head plasma membrane
0.36	GO:0009897	external side of plasma membrane
0.30	GO:0016021	integral component of membrane

0.70

GO:0004222

sp|O43508|TNF12_HUMAN
Tumor necrosis factor ligand superfamily member 12
Search

TNFSF12

0.97	Tumor necrosis factor ligand superfamily member 12

0.74	GO:0006955	immune response
0.59	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
0.58	GO:0097191	extrinsic apoptotic signaling pathway
0.56	GO:0045732	positive regulation of protein catabolic process
0.49	GO:0010469	regulation of receptor activity
0.42	GO:0001525	angiogenesis
0.40	GO:0030154	cell differentiation
0.40	GO:0043542	endothelial cell migration
0.40	GO:0001938	positive regulation of endothelial cell proliferation
0.40	GO:0033209	tumor necrosis factor-mediated signaling pathway

0.83	GO:0005164	tumor necrosis factor receptor binding
0.51	GO:0005125	cytokine activity

0.55	GO:0048471	perinuclear region of cytoplasm
0.52	GO:0005576	extracellular region
0.37	GO:0005887	integral component of plasma membrane

sp|O43511|S26A4_HUMAN
Pendrin
Search

SLC26A4

0.97

Pendrin

0.68	GO:1902358	sulfate transmembrane transport
0.56	GO:0006885	regulation of pH
0.53	GO:0032880	regulation of protein localization
0.50	GO:0015701	bicarbonate transport
0.50	GO:0019532	oxalate transport
0.48	GO:0006821	chloride transport
0.48	GO:0030004	cellular monovalent inorganic cation homeostasis
0.47	GO:0042391	regulation of membrane potential
0.40	GO:0015705	iodide transport
0.40	GO:0009651	response to salt stress

0.71	GO:0008271	secondary active sulfate transmembrane transporter activity
0.50	GO:0015106	bicarbonate transmembrane transporter activity
0.50	GO:0019531	oxalate transmembrane transporter activity
0.49	GO:0015301	anion:anion antiporter activity
0.47	GO:0005254	chloride channel activity
0.40	GO:0015111	iodide transmembrane transporter activity
0.33	GO:0003723	RNA binding

0.59	GO:0031526	brush border membrane
0.57	GO:0016324	apical plasma membrane
0.57	GO:0070062	extracellular exosome
0.43	GO:0005887	integral component of plasma membrane
0.35	GO:0005783	endoplasmic reticulum

sp|O43513|MED7_HUMAN
Mediator of RNA polymerase II transcription subunit 7
Search

MED7

0.70	Mediator of RNA polymerase II transcription subunit 7-B

0.71	GO:0006357	regulation of transcription by RNA polymerase II
0.58	GO:0006351	transcription, DNA-templated
0.54	GO:0019827	stem cell population maintenance
0.37	GO:0016567	protein ubiquitination

0.79	GO:0001104	RNA polymerase II transcription cofactor activity
0.46	GO:0003713	transcription coactivator activity
0.38	GO:0061630	ubiquitin protein ligase activity
0.34	GO:0005515	protein binding

0.77	GO:0016592	mediator complex
0.53	GO:0016604	nuclear body
0.51	GO:0005667	transcription factor complex
0.38	GO:0000151	ubiquitin ligase complex
0.34	GO:0016591	DNA-directed RNA polymerase II, holoenzyme
0.30	GO:0031224	intrinsic component of membrane

sp|O43516|WIPF1_HUMAN
WAS/WASL-interacting protein family member 1
Search

WIPF1

0.97	LOW QUALITY PROTEIN: WAS/WASL-interacting protein family member 1

0.79	GO:0008154	actin polymerization or depolymerization
0.61	GO:0030048	actin filament-based movement
0.53	GO:0043207	response to external biotic stimulus
0.48	GO:0051704	multi-organism process
0.38	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
0.35	GO:0046827	positive regulation of protein export from nucleus
0.35	GO:0006461	protein complex assembly
0.33	GO:0000147	actin cortical patch assembly
0.33	GO:0051127	positive regulation of actin nucleation
0.33	GO:0043043	peptide biosynthetic process

0.71	GO:0003779	actin binding
0.58	GO:0017124	SH3 domain binding
0.37	GO:0005522	profilin binding
0.33	GO:0003735	structural constituent of ribosome
0.33	GO:0043142	single-stranded DNA-dependent ATPase activity
0.33	GO:0017108	5'-flap endonuclease activity
0.33	GO:0022848	acetylcholine-gated cation-selective channel activity
0.32	GO:0004888	transmembrane signaling receptor activity

0.72	GO:0015629	actin cytoskeleton
0.54	GO:0099513	polymeric cytoskeletal fiber
0.39	GO:0001726	ruffle
0.37	GO:0031410	cytoplasmic vesicle
0.35	GO:0005829	cytosol
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.33	GO:0035840	old growing cell tip
0.33	GO:0031097	medial cortex
0.33	GO:0061645	endocytic patch
0.33	GO:0030863	cortical cytoskeleton

sp|O43520|AT8B1_HUMAN
Phospholipid-transporting ATPase IC
Search

ATP8B1

0.59	Phospholipid-transporting ATPase IC

0.79	GO:0045332	phospholipid translocation
0.60	GO:0021650	vestibulocochlear nerve formation
0.59	GO:0032534	regulation of microvillus assembly
0.59	GO:0015917	aminophospholipid transport
0.57	GO:0008206	bile acid metabolic process
0.56	GO:0060119	inner ear receptor cell development
0.54	GO:0007605	sensory perception of sound
0.50	GO:0006855	drug transmembrane transport
0.50	GO:0007030	Golgi organization
0.50	GO:0045892	negative regulation of transcription, DNA-templated

0.80	GO:0004012	phospholipid-translocating ATPase activity
0.64	GO:0000287	magnesium ion binding
0.60	GO:0015247	aminophospholipid transmembrane transporter activity
0.58	GO:1901612	cardiolipin binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005515	protein binding
0.32	GO:0003677	DNA binding

0.56	GO:0032420	stereocilium
0.55	GO:0016324	apical plasma membrane
0.52	GO:0005794	Golgi apparatus
0.50	GO:0005783	endoplasmic reticulum
0.39	GO:0031526	brush border membrane
0.38	GO:0030141	secretory granule
0.37	GO:0097223	sperm part
0.34	GO:0030659	cytoplasmic vesicle membrane
0.34	GO:0005887	integral component of plasma membrane
0.34	GO:0098805	whole membrane

0.80

GO:0004012

sp|O43521|B2L11_HUMAN
Bcl-2-like protein 11
Search

sp|O43524|FOXO3_HUMAN
Forkhead box protein O3
Search

FOXO3

0.96	Forkhead protein FKHR

0.68	GO:0001544	initiation of primordial ovarian follicle growth
0.66	GO:0001547	antral ovarian follicle growth
0.65	GO:0001542	ovulation from ovarian follicle
0.64	GO:0043525	positive regulation of neuron apoptotic process
0.64	GO:0045648	positive regulation of erythrocyte differentiation
0.64	GO:0001556	oocyte maturation
0.63	GO:0038034	signal transduction in absence of ligand
0.63	GO:0097150	neuronal stem cell population maintenance
0.63	GO:0030330	DNA damage response, signal transduction by p53 class mediator
0.63	GO:0033209	tumor necrosis factor-mediated signaling pathway

0.64	GO:0043565	sequence-specific DNA binding
0.61	GO:0031490	chromatin DNA binding
0.61	GO:0008013	beta-catenin binding
0.61	GO:0003700	DNA binding transcription factor activity
0.61	GO:0001047	core promoter binding
0.58	GO:0019901	protein kinase binding
0.42	GO:0001221	transcription cofactor binding
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding
0.32	GO:0008144	drug binding

0.61	GO:0005634	nucleus
0.53	GO:0005829	cytosol
0.51	GO:0070013	intracellular organelle lumen
0.46	GO:0044446	intracellular organelle part
0.36	GO:0005739	mitochondrion
0.30	GO:0016020	membrane

sp|O43525|KCNQ3_HUMAN
Potassium voltage-gated channel subfamily KQT member 3
Search

KCNQ3

0.58	Voltage-gated potassium channel

0.72	GO:0071805	potassium ion transmembrane transport
0.60	GO:0060081	membrane hyperpolarization
0.40	GO:0034765	regulation of ion transmembrane transport
0.37	GO:0007268	chemical synaptic transmission
0.36	GO:0061548	ganglion development
0.36	GO:0014003	oligodendrocyte development
0.36	GO:0071242	cellular response to ammonium ion
0.33	GO:0042472	inner ear morphogenesis
0.33	GO:0007605	sensory perception of sound

0.77	GO:0005249	voltage-gated potassium channel activity
0.54	GO:0005516	calmodulin binding
0.36	GO:0044325	ion channel binding
0.35	GO:0031625	ubiquitin protein ligase binding
0.35	GO:0019901	protein kinase binding

0.77	GO:0008076	voltage-gated potassium channel complex
0.60	GO:0043194	axon initial segment
0.60	GO:0033268	node of Ranvier
0.53	GO:0009986	cell surface
0.35	GO:0043025	neuronal cell body
0.35	GO:0030425	dendrite
0.35	GO:0045121	membrane raft

sp|O43526|KCNQ2_HUMAN
Potassium voltage-gated channel subfamily KQT member 2
Search

KCNQ2

0.91	Potassium voltage-gated channel subfamily KQT member 2

0.73	GO:0071805	potassium ion transmembrane transport
0.39	GO:0034765	regulation of ion transmembrane transport
0.38	GO:0019226	transmission of nerve impulse
0.36	GO:0007268	chemical synaptic transmission
0.36	GO:0007399	nervous system development
0.33	GO:0006414	translational elongation

0.77	GO:0005249	voltage-gated potassium channel activity
0.58	GO:0030506	ankyrin binding
0.53	GO:0005516	calmodulin binding
0.36	GO:0047485	protein N-terminus binding
0.33	GO:0003746	translation elongation factor activity
0.33	GO:0003924	GTPase activity
0.33	GO:0005525	GTP binding

0.77	GO:0008076	voltage-gated potassium channel complex
0.41	GO:0043194	axon initial segment
0.41	GO:0033268	node of Ranvier
0.36	GO:0009986	cell surface
0.33	GO:0043234	protein complex
0.32	GO:0005737	cytoplasm

sp|O43529|CHSTA_HUMAN
Carbohydrate sulfotransferase 10
Search

CHST10

0.67	Carbohydrate sulfotransferase

0.66	GO:0016051	carbohydrate biosynthetic process
0.37	GO:0007616	long-term memory
0.37	GO:0007612	learning
0.34	GO:0007155	cell adhesion

0.77

GO:0008146

sulfotransferase activity

0.74	GO:0000139	Golgi membrane
0.30	GO:0031224	intrinsic component of membrane

0.77

GO:0008146

sp|O43541|SMAD6_HUMAN
Mothers against decapentaplegic homolog 6
Search

SMAD6

0.65	Mothers against decapentaplegic homolog

0.76	GO:0007179	transforming growth factor beta receptor signaling pathway
0.60	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
0.60	GO:0007352	zygotic specification of dorsal/ventral axis
0.59	GO:0010991	negative regulation of SMAD protein complex assembly
0.59	GO:0034616	response to laminar fluid shear stress
0.59	GO:0030514	negative regulation of BMP signaling pathway
0.58	GO:0003183	mitral valve morphogenesis
0.58	GO:0003184	pulmonary valve morphogenesis
0.57	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II
0.57	GO:0003148	outflow tract septum morphogenesis

0.60	GO:0070698	type I activin receptor binding
0.60	GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
0.58	GO:0070410	co-SMAD binding
0.58	GO:0070411	I-SMAD binding
0.58	GO:0034713	type I transforming growth factor beta receptor binding
0.58	GO:0070412	R-SMAD binding
0.57	GO:0003700	DNA binding transcription factor activity
0.53	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.53	GO:0031625	ubiquitin protein ligase binding
0.52	GO:0003682	chromatin binding

0.69	GO:0005667	transcription factor complex
0.57	GO:0005634	nucleus
0.49	GO:0005794	Golgi apparatus
0.48	GO:0005829	cytosol
0.47	GO:0070013	intracellular organelle lumen
0.43	GO:0044446	intracellular organelle part
0.36	GO:0005768	endosome
0.34	GO:0005694	chromosome

sp|O43542|XRCC3_HUMAN
DNA repair protein XRCC3
Search

XRCC3

0.92	X-ray repair complementing defective repair in Chinese hamster cells 3

0.77	GO:0071140	resolution of mitotic recombination intermediates
0.75	GO:0001325	formation of extrachromosomal circular DNA
0.75	GO:0090737	telomere maintenance via telomere trimming
0.73	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint
0.71	GO:0000722	telomere maintenance via recombination
0.70	GO:0010824	regulation of centrosome duplication
0.68	GO:0036297	interstrand cross-link repair
0.66	GO:0000724	double-strand break repair via homologous recombination
0.57	GO:0042148	strand invasion
0.56	GO:0090735	DNA repair complex assembly

0.74	GO:0000400	four-way junction DNA binding
0.70	GO:0008094	DNA-dependent ATPase activity
0.66	GO:0008821	crossover junction endodeoxyribonuclease activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0000150	recombinase activity
0.50	GO:0003697	single-stranded DNA binding
0.49	GO:0003690	double-stranded DNA binding

0.76	GO:0033065	Rad51C-XRCC3 complex
0.66	GO:0048471	perinuclear region of cytoplasm
0.64	GO:0005657	replication fork
0.59	GO:0005654	nucleoplasm
0.58	GO:0005829	cytosol
0.56	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex
0.52	GO:0005739	mitochondrion

0.66

EC:3.1.22.4

GO:0008821

sp|O43543|XRCC2_HUMAN
DNA repair protein XRCC2
Search

XRCC2

0.92	DNA repair protein XRCC2

0.77	GO:0000724	double-strand break repair via homologous recombination
0.49	GO:2000269	regulation of fibroblast apoptotic process
0.49	GO:0042148	strand invasion
0.49	GO:0010165	response to X-ray
0.48	GO:0010332	response to gamma radiation
0.48	GO:0001756	somitogenesis
0.48	GO:0035264	multicellular organism growth
0.48	GO:0043524	negative regulation of neuron apoptotic process
0.47	GO:0007098	centrosome cycle
0.47	GO:0001701	in utero embryonic development

0.69	GO:0008094	DNA-dependent ATPase activity
0.55	GO:0003677	DNA binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.41	GO:0000150	recombinase activity
0.41	GO:0004520	endodeoxyribonuclease activity
0.37	GO:0005515	protein binding

0.85	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex
0.74	GO:0005657	replication fork
0.46	GO:0005813	centrosome
0.43	GO:0005654	nucleoplasm
0.33	GO:0005737	cytoplasm

sp|O43548|TGM5_HUMAN
Protein-glutamine gamma-glutamyltransferase 5
Search

TGM5

0.94	Transglutaminase Z

0.84	GO:0018149	peptide cross-linking
0.43	GO:0030216	keratinocyte differentiation
0.41	GO:0051262	protein tetramerization
0.40	GO:0043163	cell envelope organization
0.35	GO:0012501	programmed cell death
0.34	GO:0031069	hair follicle morphogenesis
0.32	GO:0032259	methylation

0.84	GO:0003810	protein-glutamine gamma-glutamyltransferase activity
0.39	GO:0005509	calcium ion binding
0.33	GO:0008168	methyltransferase activity

0.40	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.36	GO:0005737	cytoplasm
0.33	GO:0070062	extracellular exosome

0.84

EC:2.3.2.13

GO:0003810

sp|O43555|GON2_HUMAN
Progonadoliberin-2
Search

GNRH2

0.67	Gonadotropin releasing hormone 2

0.76	GO:0010469	regulation of receptor activity
0.70	GO:0007275	multicellular organism development
0.45	GO:2000843	regulation of testosterone secretion
0.45	GO:0033686	positive regulation of luteinizing hormone secretion
0.44	GO:0032275	luteinizing hormone secretion
0.43	GO:0060322	head development
0.37	GO:0007186	G-protein coupled receptor signaling pathway
0.34	GO:0035335	peptidyl-tyrosine dephosphorylation
0.34	GO:0009755	hormone-mediated signaling pathway
0.33	GO:0000003	reproduction

0.79	GO:0005179	hormone activity
0.34	GO:0004725	protein tyrosine phosphatase activity

0.66	GO:0005576	extracellular region
0.43	GO:0005763	mitochondrial small ribosomal subunit
0.30	GO:0016020	membrane

0.34

GO:0004725

sp|O43556|SGCE_HUMAN
Epsilon-sarcoglycan
Search

SGCE

0.66	Brain epsilon-sarcoglycan

0.46	GO:0003012	muscle system process
0.42	GO:0061024	membrane organization
0.36	GO:0007517	muscle organ development
0.35	GO:0007160	cell-matrix adhesion
0.35	GO:0001822	kidney development
0.35	GO:0014706	striated muscle tissue development
0.34	GO:0007420	brain development

0.41	GO:0005509	calcium ion binding
0.33	GO:0005515	protein binding

0.85	GO:0016012	sarcoglycan complex
0.55	GO:0032590	dendrite membrane
0.47	GO:0005794	Golgi apparatus
0.41	GO:0042383	sarcolemma
0.38	GO:0005856	cytoskeleton
0.35	GO:0005887	integral component of plasma membrane

sp|O43557|TNF14_HUMAN
Tumor necrosis factor ligand superfamily member 14
Search

TNFSF14

0.97	Tumor necrosis factor ligand superfamily member 14

0.76	GO:0008588	release of cytoplasmic sequestered NF-kappaB
0.74	GO:0006955	immune response
0.70	GO:0010820	positive regulation of T cell chemotaxis
0.70	GO:0071260	cellular response to mechanical stimulus
0.69	GO:1901741	positive regulation of myoblast fusion
0.69	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.69	GO:0031295	T cell costimulation
0.68	GO:0045663	positive regulation of myoblast differentiation
0.64	GO:0006915	apoptotic process
0.58	GO:0010469	regulation of receptor activity

0.84	GO:0005164	tumor necrosis factor receptor binding
0.72	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.61	GO:0005125	cytokine activity
0.41	GO:0042802	identical protein binding

0.56	GO:0005615	extracellular space
0.41	GO:0005622	intracellular
0.36	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O43559|FRS3_HUMAN
Fibroblast growth factor receptor substrate 3
Search

FRS3

0.93	Fibroblast growth factor receptor substrate 3

0.83	GO:0008543	fibroblast growth factor receptor signaling pathway
0.61	GO:0046619	optic placode formation involved in camera-type eye formation
0.60	GO:0060526	prostate glandular acinus morphogenesis
0.60	GO:2000726	negative regulation of cardiac muscle cell differentiation
0.60	GO:0060442	branching involved in prostate gland morphogenesis
0.59	GO:0070307	lens fiber cell development
0.59	GO:0001759	organ induction
0.58	GO:0001702	gastrulation with mouth forming second
0.57	GO:0007405	neuroblast proliferation
0.57	GO:0003281	ventricular septum development

0.84	GO:0005104	fibroblast growth factor receptor binding
0.67	GO:0042802	identical protein binding
0.61	GO:0005168	neurotrophin TRKA receptor binding
0.60	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
0.39	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.38	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity
0.36	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.36	GO:0016303	1-phosphatidylinositol-3-kinase activity
0.36	GO:0019211	phosphatase activator activity

0.56	GO:0005913	cell-cell adherens junction
0.44	GO:0005886	plasma membrane
0.39	GO:0005737	cytoplasm
0.34	GO:0097708	intracellular vesicle
0.34	GO:0012505	endomembrane system
0.30	GO:0016021	integral component of membrane

0.38	EC:3.4.19.12	GO:0036459
0.36	KEGG:R04545	GO:0046934

sp|O43561|LAT_HUMAN
Linker for activation of T-cells family member 1
Search

LAT

0.94	Linker for activation of T-cells

0.64	GO:0019722	calcium-mediated signaling
0.64	GO:0007265	Ras protein signal transduction
0.64	GO:0002260	lymphocyte homeostasis
0.62	GO:0007229	integrin-mediated signaling pathway
0.61	GO:0045860	positive regulation of protein kinase activity
0.60	GO:0050863	regulation of T cell activation
0.60	GO:0006954	inflammatory response
0.59	GO:0009967	positive regulation of signal transduction
0.58	GO:0006955	immune response
0.46	GO:0002448	mast cell mediated immunity

0.66	GO:0005070	SH3/SH2 adaptor activity
0.61	GO:0019901	protein kinase binding
0.40	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.36	GO:0005057	signal transducer activity, downstream of receptor

0.67	GO:0001772	immunological synapse
0.60	GO:0008180	COP9 signalosome
0.58	GO:0005794	Golgi apparatus
0.58	GO:0005911	cell-cell junction
0.45	GO:0042629	mast cell granule
0.41	GO:0045121	membrane raft
0.34	GO:0005887	integral component of plasma membrane

sp|O43566|RGS14_HUMAN
Regulator of G-protein signaling 14
Search

RGS14

0.97	Regulator of G-protein signaling 14

0.73	GO:0007051	spindle organization
0.72	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.70	GO:0043547	positive regulation of GTPase activity
0.66	GO:0010070	zygote asymmetric cell division
0.66	GO:0031914	negative regulation of synaptic plasticity
0.62	GO:0060291	long-term synaptic potentiation
0.62	GO:0007616	long-term memory
0.60	GO:0007612	learning
0.60	GO:0043407	negative regulation of MAP kinase activity
0.60	GO:0007165	signal transduction

0.79	GO:0001965	G-protein alpha-subunit binding
0.78	GO:0005057	signal transducer activity, downstream of receptor
0.75	GO:0005092	GDP-dissociation inhibitor activity
0.70	GO:0005096	GTPase activator activity
0.68	GO:0008017	microtubule binding
0.64	GO:0032794	GTPase activating protein binding
0.42	GO:0030159	receptor signaling complex scaffold activity
0.40	GO:0019901	protein kinase binding

0.61	GO:0043197	dendritic spine
0.60	GO:0014069	postsynaptic density
0.57	GO:0005813	centrosome
0.57	GO:0016604	nuclear body
0.56	GO:0005819	spindle
0.46	GO:0005886	plasma membrane
0.42	GO:0005737	cytoplasm
0.40	GO:0030054	cell junction
0.39	GO:0005874	microtubule
0.38	GO:0005730	nucleolus

sp|O43567|RNF13_HUMAN
E3 ubiquitin-protein ligase RNF13
Search

RNF13

0.92	Ring finger protein 13

0.64

GO:0051865

protein autoubiquitination

0.59	GO:0061630	ubiquitin protein ligase activity
0.46	GO:0008270	zinc ion binding

0.63	GO:0031902	late endosome membrane
0.62	GO:0005765	lysosomal membrane
0.58	GO:0005654	nucleoplasm
0.57	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O43570|CAH12_HUMAN
Carbonic anhydrase 12
Search

CA12

0.97	Carbonic anhydrase XII

0.70	GO:0006730	one-carbon metabolic process
0.58	GO:0055064	chloride ion homeostasis
0.37	GO:0006885	regulation of pH
0.37	GO:0097369	sodium ion import
0.36	GO:0015701	bicarbonate transport
0.36	GO:0015670	carbon dioxide transport

0.77	GO:0004089	carbonate dehydratase activity
0.62	GO:0008270	zinc ion binding

0.36	GO:0009897	external side of plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.77

EC:4.2.1.1

GO:0004089

sp|O43572|AKA10_HUMAN
A-kinase anchor protein 10, mitochondrial
Search

AKAP10

0.95	A-kinase anchoring protein 10

0.60

GO:0008104

protein localization

0.85

GO:0051018

protein kinase A binding

0.66	GO:0005829	cytosol
0.57	GO:0043234	protein complex
0.57	GO:0005739	mitochondrion
0.54	GO:0005886	plasma membrane

sp|O43581|SYT7_HUMAN
Synaptotagmin-7
Search

SYT7

0.84	Synaptotagmin VIIa

0.76	GO:0006887	exocytosis
0.53	GO:0007269	neurotransmitter secretion
0.51	GO:0017158	regulation of calcium ion-dependent exocytosis
0.50	GO:0097480	establishment of synaptic vesicle localization
0.50	GO:0090119	vesicle-mediated cholesterol transport
0.50	GO:0099504	synaptic vesicle cycle
0.50	GO:0099003	vesicle-mediated transport in synapse
0.50	GO:0006906	vesicle fusion
0.49	GO:1990926	short-term synaptic potentiation
0.49	GO:0070092	regulation of glucagon secretion

0.81	GO:0005544	calcium-dependent phospholipid binding
0.50	GO:0000149	SNARE binding
0.47	GO:0001786	phosphatidylserine binding
0.47	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.46	GO:0030276	clathrin binding
0.45	GO:0005516	calmodulin binding
0.43	GO:0005509	calcium ion binding

0.51	GO:0098793	presynapse
0.48	GO:0032009	early phagosome
0.48	GO:0070382	exocytic vesicle
0.46	GO:0044306	neuron projection terminus
0.45	GO:0043025	neuronal cell body
0.45	GO:0030425	dendrite
0.45	GO:0097060	synaptic membrane
0.45	GO:0005764	lysosome
0.44	GO:0005777	peroxisome
0.43	GO:0031045	dense core granule

sp|O43583|DENR_HUMAN
Density-regulated protein
Search

DENR

0.89	Density-regulated protein (Fragment)

0.71	GO:0006413	translational initiation
0.56	GO:0075522	IRES-dependent viral translational initiation
0.54	GO:0032790	ribosome disassembly
0.53	GO:0002181	cytoplasmic translation
0.51	GO:0022618	ribonucleoprotein complex assembly
0.34	GO:0006915	apoptotic process
0.33	GO:0072583	clathrin-dependent endocytosis

0.71	GO:0003743	translation initiation factor activity
0.45	GO:0003729	mRNA binding
0.45	GO:0043022	ribosome binding
0.34	GO:0005515	protein binding
0.33	GO:0035091	phosphatidylinositol binding

0.51	GO:0070992	translation initiation complex
0.40	GO:0005840	ribosome
0.34	GO:0005905	clathrin-coated pit
0.34	GO:0030136	clathrin-coated vesicle
0.30	GO:0016021	integral component of membrane

sp|O43586|PPIP1_HUMAN
Proline-serine-threonine phosphatase-interacting protein 1
Search

PSTPIP1

0.97	Proline-serine-threonine phosphatase-interacting protein 1

0.43	GO:0006954	inflammatory response
0.42	GO:0045087	innate immune response
0.41	GO:0016477	cell migration
0.41	GO:0007155	cell adhesion
0.41	GO:0006897	endocytosis
0.39	GO:0007010	cytoskeleton organization
0.36	GO:0007165	signal transduction

0.72	GO:0042802	identical protein binding
0.44	GO:0003779	actin binding
0.43	GO:0019903	protein phosphatase binding
0.33	GO:0003676	nucleic acid binding

0.47	GO:0097610	cell surface furrow
0.46	GO:0032155	cell division site part
0.45	GO:0001931	uropod
0.44	GO:0097517	contractile actin filament bundle
0.44	GO:0042641	actomyosin
0.43	GO:0070938	contractile ring
0.43	GO:0030027	lamellipodium
0.42	GO:0048471	perinuclear region of cytoplasm
0.42	GO:0030864	cortical actin cytoskeleton
0.37	GO:0005829	cytosol

sp|O43592|XPOT_HUMAN
Exportin-T
Search

XPOT

0.85	LOW QUALITY PROTEIN: exportin-T

0.63	GO:0006886	intracellular protein transport
0.58	GO:0051031	tRNA transport
0.57	GO:0097064	ncRNA export from nucleus
0.54	GO:0071166	ribonucleoprotein complex localization
0.54	GO:0051169	nuclear transport
0.35	GO:0006468	protein phosphorylation

0.72	GO:0008536	Ran GTPase binding
0.49	GO:0000049	tRNA binding
0.35	GO:0004672	protein kinase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.60	GO:0005634	nucleus
0.48	GO:0031974	membrane-enclosed lumen
0.48	GO:0012505	endomembrane system
0.47	GO:0005829	cytosol
0.45	GO:0031967	organelle envelope
0.44	GO:0043234	protein complex
0.30	GO:0016020	membrane

sp|O43593|HAIR_HUMAN
Lysine-specific demethylase hairless
Search

0.97	Lysine-specific demethylase hairless

0.67	GO:0033169	histone H3-K9 demethylation
0.66	GO:0045892	negative regulation of transcription, DNA-templated
0.44	GO:0032259	methylation
0.40	GO:0051291	protein heterooligomerization
0.39	GO:0043433	negative regulation of DNA binding transcription factor activity
0.39	GO:0006351	transcription, DNA-templated
0.38	GO:0031937	positive regulation of chromatin silencing
0.37	GO:0055114	oxidation-reduction process
0.33	GO:1990636	reproductive senescence
0.33	GO:0048468	cell development

0.74	GO:0003714	transcription corepressor activity
0.67	GO:0032454	histone demethylase activity (H3-K9 specific)
0.63	GO:0031490	chromatin DNA binding
0.58	GO:0000976	transcription regulatory region sequence-specific DNA binding
0.44	GO:0008168	methyltransferase activity
0.41	GO:0042809	vitamin D receptor binding
0.41	GO:0046966	thyroid hormone receptor binding
0.40	GO:0042826	histone deacetylase binding
0.38	GO:0046872	metal ion binding
0.38	GO:0016491	oxidoreductase activity

0.71	GO:0016604	nuclear body
0.56	GO:0000785	chromatin
0.39	GO:0000118	histone deacetylase complex
0.30	GO:0031224	intrinsic component of membrane

0.44

GO:0008168

sp|O43597|SPY2_HUMAN
Protein sprouty homolog 2
Search

SPRY2

0.97	Sprouty RTK signaling antagonist 2

0.85	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.84	GO:0046580	negative regulation of Ras protein signal transduction
0.76	GO:0042127	regulation of cell proliferation
0.70	GO:0045595	regulation of cell differentiation
0.70	GO:0007275	multicellular organism development
0.62	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway
0.62	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
0.61	GO:0060602	branch elongation of an epithelium
0.60	GO:2000026	regulation of multicellular organismal development
0.60	GO:0034260	negative regulation of GTPase activity

0.55	GO:0043539	protein serine/threonine kinase activator activity
0.52	GO:0019901	protein kinase binding
0.35	GO:0030291	protein serine/threonine kinase inhibitor activity

0.50	GO:0005829	cytosol
0.50	GO:0015630	microtubule cytoskeleton
0.46	GO:0005634	nucleus
0.42	GO:0005794	Golgi apparatus
0.42	GO:0032587	ruffle membrane
0.41	GO:0031974	membrane-enclosed lumen
0.40	GO:0044446	intracellular organelle part
0.39	GO:0099512	supramolecular fiber
0.30	GO:0016021	integral component of membrane

sp|O43598|DNPH1_HUMAN
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Search

DNPH1

0.94	2'-deoxynucleoside 5'-phosphate N-hydrolase 1

0.83	GO:0009159	deoxyribonucleoside monophosphate catabolic process
0.64	GO:0009116	nucleoside metabolic process
0.58	GO:0009117	nucleotide metabolic process
0.51	GO:0030855	epithelial cell differentiation
0.43	GO:0030307	positive regulation of cell growth
0.36	GO:0008283	cell proliferation
0.36	GO:0072523	purine-containing compound catabolic process
0.34	GO:0007021	tubulin complex assembly
0.34	GO:0007023	post-chaperonin tubulin folding pathway
0.33	GO:0043547	positive regulation of GTPase activity

0.83	GO:0070694	deoxyribonucleoside 5'-monophosphate N-glycosidase activity
0.83	GO:0050144	nucleoside deoxyribosyltransferase activity
0.55	GO:0042803	protein homodimerization activity
0.34	GO:0048487	beta-tubulin binding
0.33	GO:0004252	serine-type endopeptidase activity
0.33	GO:0005096	GTPase activator activity
0.32	GO:0016491	oxidoreductase activity

0.54	GO:0005634	nucleus
0.45	GO:0005737	cytoplasm
0.38	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.83

EC:3.2.2

GO:0070694

sp|O43602|DCX_HUMAN
Neuronal migration protein doublecortin
Search

DCX

0.97	Neuronal migration protein doublecortin

0.63	GO:0035556	intracellular signal transduction
0.58	GO:0021860	pyramidal neuron development
0.56	GO:0021819	layer formation in cerebral cortex
0.56	GO:0021766	hippocampus development
0.55	GO:0021952	central nervous system projection neuron axonogenesis
0.54	GO:0048675	axon extension
0.54	GO:0001764	neuron migration
0.54	GO:0048813	dendrite morphogenesis
0.44	GO:0006468	protein phosphorylation
0.40	GO:0018209	peptidyl-serine modification

0.44	GO:0004672	protein kinase activity
0.40	GO:0032559	adenyl ribonucleotide binding
0.40	GO:0008144	drug binding
0.40	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0019901	protein kinase binding
0.36	GO:0008017	microtubule binding
0.36	GO:0004198	calcium-dependent cysteine-type endopeptidase activity
0.33	GO:0005516	calmodulin binding
0.32	GO:0003677	DNA binding

0.51	GO:0043005	neuron projection
0.48	GO:0005829	cytosol
0.39	GO:0015630	microtubule cytoskeleton
0.39	GO:0099513	polymeric cytoskeletal fiber
0.34	GO:0043025	neuronal cell body
0.34	GO:0030427	site of polarized growth
0.34	GO:0120038	plasma membrane bounded cell projection part
0.33	GO:0005634	nucleus
0.33	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

sp|O43603|GALR2_HUMAN
Galanin receptor type 2
Search

GALR2

0.92	Galanin receptor type 2

0.70	GO:0007186	G-protein coupled receptor signaling pathway
0.60	GO:0007194	negative regulation of adenylate cyclase activity
0.57	GO:1902608	positive regulation of large conductance calcium-activated potassium channel activity
0.56	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.50	GO:0031175	neuron projection development
0.50	GO:0045944	positive regulation of transcription by RNA polymerase II
0.39	GO:0019933	cAMP-mediated signaling
0.38	GO:0043647	inositol phosphate metabolic process
0.38	GO:0046488	phosphatidylinositol metabolic process
0.37	GO:0007631	feeding behavior

0.71	GO:0004930	G-protein coupled receptor activity
0.60	GO:0001653	peptide receptor activity
0.56	GO:0017046	peptide hormone binding
0.40	GO:0042923	neuropeptide binding
0.35	GO:0005230	extracellular ligand-gated ion channel activity
0.34	GO:0005515	protein binding

0.42	GO:0005887	integral component of plasma membrane
0.38	GO:0097730	non-motile cilium
0.33	GO:0005622	intracellular

sp|O43609|SPY1_HUMAN
Protein sprouty homolog 1
Search

SPRY1

0.97	Sprouty RTK signaling antagonist 1

0.85	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.84	GO:0046580	negative regulation of Ras protein signal transduction
0.83	GO:0001759	organ induction
0.76	GO:0042127	regulation of cell proliferation
0.70	GO:0007275	multicellular organism development
0.65	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway
0.64	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
0.64	GO:0060602	branch elongation of an epithelium
0.63	GO:0034260	negative regulation of GTPase activity
0.61	GO:0000132	establishment of mitotic spindle orientation

0.47	GO:0043539	protein serine/threonine kinase activator activity
0.45	GO:0019901	protein kinase binding
0.34	GO:0030291	protein serine/threonine kinase inhibitor activity

0.52	GO:0005829	cytosol
0.51	GO:0005794	Golgi apparatus
0.50	GO:0005654	nucleoplasm
0.44	GO:0015630	microtubule cytoskeleton
0.39	GO:0032587	ruffle membrane
0.37	GO:0099513	polymeric cytoskeletal fiber
0.30	GO:0016021	integral component of membrane

sp|O43610|SPY3_HUMAN
Protein sprouty homolog 3
Search

SPRY3

0.97	Sprouty RTK signaling antagonist 3

0.70	GO:0007275	multicellular organism development
0.70	GO:0009966	regulation of signal transduction
0.65	GO:0120036	plasma membrane bounded cell projection organization
0.64	GO:0030154	cell differentiation
0.60	GO:0042127	regulation of cell proliferation
0.59	GO:0045595	regulation of cell differentiation
0.59	GO:0001933	negative regulation of protein phosphorylation
0.58	GO:0023057	negative regulation of signaling
0.58	GO:0010648	negative regulation of cell communication
0.57	GO:0048585	negative regulation of response to stimulus

0.49	GO:0043539	protein serine/threonine kinase activator activity
0.46	GO:0019901	protein kinase binding
0.34	GO:0030291	protein serine/threonine kinase inhibitor activity

0.44	GO:0015630	microtubule cytoskeleton
0.43	GO:0005829	cytosol
0.40	GO:0005634	nucleus
0.38	GO:0032587	ruffle membrane
0.36	GO:0099513	polymeric cytoskeletal fiber
0.33	GO:0005794	Golgi apparatus
0.32	GO:0031974	membrane-enclosed lumen
0.30	GO:0016021	integral component of membrane

sp|O43612|OREX_HUMAN
Orexin
Search

HCRT

0.91	Hypocretin neuropeptide precursor

0.84	GO:0007631	feeding behavior
0.80	GO:0007218	neuropeptide signaling pathway
0.60	GO:0042746	circadian sleep/wake cycle, wakefulness
0.56	GO:0030431	sleep
0.55	GO:0033555	multicellular organismal response to stress
0.51	GO:0042594	response to starvation
0.35	GO:0035556	intracellular signal transduction
0.30	GO:0001659	temperature homeostasis
0.30	GO:0031645	negative regulation of neurological system process
0.30	GO:0031646	positive regulation of neurological system process

0.30	GO:0005515	protein binding
0.30	GO:0098772	molecular function regulator

0.45	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0043227	membrane-bounded organelle
0.30	GO:0044456	synapse part
0.30	GO:0097458	neuron part
0.30	GO:0005576	extracellular region
0.30	GO:0043229	intracellular organelle
0.30	GO:0012505	endomembrane system
0.30	GO:0030054	cell junction

sp|O43613|OX1R_HUMAN
Orexin receptor type 1
Search

HCRTR2

0.91	Hypocretin receptor 1

0.84	GO:0007631	feeding behavior
0.78	GO:0022410	circadian sleep/wake cycle process
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.71	GO:0051480	regulation of cytosolic calcium ion concentration
0.62	GO:0045187	regulation of circadian sleep/wake cycle, sleep
0.58	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.53	GO:0030186	melatonin metabolic process
0.53	GO:1901652	response to peptide
0.51	GO:0032870	cellular response to hormone stimulus

0.87	GO:0016499	orexin receptor activity
0.52	GO:0042277	peptide binding

0.60	GO:0005887	integral component of plasma membrane
0.43	GO:0045177	apical part of cell
0.43	GO:0048471	perinuclear region of cytoplasm

sp|O43614|OX2R_HUMAN
Orexin receptor type 2
Search

HCRTR2

0.92	Hypocretin receptor-2

0.84	GO:0007631	feeding behavior
0.82	GO:0022410	circadian sleep/wake cycle process
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.70	GO:0051480	regulation of cytosolic calcium ion concentration
0.62	GO:0045187	regulation of circadian sleep/wake cycle, sleep
0.54	GO:0030186	melatonin metabolic process
0.53	GO:1901652	response to peptide
0.52	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.51	GO:0032870	cellular response to hormone stimulus

0.87	GO:0016499	orexin receptor activity
0.52	GO:0042277	peptide binding

0.60	GO:0005887	integral component of plasma membrane
0.44	GO:0045177	apical part of cell
0.44	GO:0048471	perinuclear region of cytoplasm

sp|O43615|TIM44_HUMAN
Mitochondrial import inner membrane translocase subunit TIM44
Search

TIMM44

0.78	Mitochondrial import inner membrane translocase subunit TIM44

0.80	GO:0030150	protein import into mitochondrial matrix
0.36	GO:1905242	response to 3,3',5-triiodo-L-thyronine
0.35	GO:0055007	cardiac muscle cell differentiation

0.76	GO:0051087	chaperone binding
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.56	GO:0031966	mitochondrial membrane
0.56	GO:0019866	organelle inner membrane
0.50	GO:0005759	mitochondrial matrix

sp|O43617|TPPC3_HUMAN
Trafficking protein particle complex subunit 3
Search

TRAPPC3

0.77	Trafficking protein particle complex subunit

0.75	GO:0048193	Golgi vesicle transport
0.48	GO:0046907	intracellular transport
0.35	GO:0006901	vesicle coating
0.35	GO:0006903	vesicle targeting
0.33	GO:0006461	protein complex assembly
0.33	GO:0065009	regulation of molecular function

0.35

GO:0017112

Rab guanyl-nucleotide exchange factor activity

0.81	GO:0030008	TRAPP complex
0.66	GO:0005794	Golgi apparatus
0.65	GO:0005783	endoplasmic reticulum
0.48	GO:0098588	bounding membrane of organelle
0.48	GO:0005829	cytosol
0.47	GO:0031984	organelle subcompartment
0.30	GO:0031224	intrinsic component of membrane

sp|O43623|SNAI2_HUMAN
Zinc finger protein SNAI2
Search

SNAI2

0.92	Zinc finger transcription factor snail 2

0.75	GO:0035921	desmosome disassembly
0.74	GO:1900387	negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter
0.74	GO:0070563	negative regulation of vitamin D receptor signaling pathway
0.72	GO:0010957	negative regulation of vitamin D biosynthetic process
0.71	GO:0035414	negative regulation of catenin import into nucleus
0.71	GO:0010839	negative regulation of keratinocyte proliferation
0.71	GO:2000810	regulation of bicellular tight junction assembly
0.71	GO:2000811	negative regulation of anoikis
0.70	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
0.70	GO:0032331	negative regulation of chondrocyte differentiation

0.67	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.53	GO:0043565	sequence-specific DNA binding
0.52	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.49	GO:0003682	chromatin binding
0.34	GO:0005515	protein binding
0.33	GO:0046872	metal ion binding

0.61	GO:0000790	nuclear chromatin
0.38	GO:0005737	cytoplasm

sp|O43633|CHM2A_HUMAN
Charged multivesicular body protein 2a
Search

CHMP2A

0.91	Charged multivesicular body protein 2A

0.78	GO:0007034	vacuolar transport
0.55	GO:1903723	negative regulation of centriole elongation
0.54	GO:0010458	exit from mitosis
0.53	GO:0031468	nuclear envelope reassembly
0.53	GO:1903543	positive regulation of exosomal secretion
0.53	GO:1902188	positive regulation of viral release from host cell
0.52	GO:1901673	regulation of mitotic spindle assembly
0.52	GO:0000920	cell separation after cytokinesis
0.51	GO:0051291	protein heterooligomerization
0.51	GO:0010324	membrane invagination

0.52	GO:0031210	phosphatidylcholine binding
0.48	GO:0019904	protein domain specific binding

0.52	GO:0000815	ESCRT III complex
0.49	GO:0005635	nuclear envelope
0.47	GO:0030117	membrane coat
0.46	GO:0000785	chromatin
0.43	GO:0005829	cytosol
0.40	GO:0031902	late endosome membrane
0.36	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

sp|O43638|FOXS1_HUMAN
Forkhead box protein S1
Search

FOXS1

0.90	Forkhead box protein S1

0.67	GO:0001944	vasculature development
0.58	GO:0048638	regulation of developmental growth
0.57	GO:0000122	negative regulation of transcription by RNA polymerase II
0.57	GO:0050885	neuromuscular process controlling balance
0.57	GO:0051094	positive regulation of developmental process
0.56	GO:0051240	positive regulation of multicellular organismal process
0.55	GO:0043433	negative regulation of DNA binding transcription factor activity
0.54	GO:0045927	positive regulation of growth
0.51	GO:1902257	negative regulation of apoptotic process involved in outflow tract morphogenesis
0.50	GO:0030154	cell differentiation

0.61	GO:0043565	sequence-specific DNA binding
0.58	GO:0003700	DNA binding transcription factor activity
0.56	GO:0044212	transcription regulatory region DNA binding
0.51	GO:0003690	double-stranded DNA binding
0.48	GO:1990841	promoter-specific chromatin binding
0.45	GO:0031490	chromatin DNA binding
0.42	GO:0042802	identical protein binding
0.41	GO:0001223	transcription coactivator binding
0.39	GO:0008301	DNA binding, bending
0.39	GO:0003713	transcription coactivator activity

0.58	GO:0005634	nucleus
0.42	GO:0070013	intracellular organelle lumen
0.39	GO:0044446	intracellular organelle part
0.37	GO:0005829	cytosol
0.36	GO:0005694	chromosome

0.35

GO:0008138

sp|O43639|NCK2_HUMAN
Cytoplasmic protein NCK2
Search

NCK2

0.96	NCK adaptor protein 2

0.75	GO:0009967	positive regulation of signal transduction
0.61	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
0.61	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress
0.61	GO:1903898	negative regulation of PERK-mediated unfolded protein response
0.60	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
0.58	GO:0033137	negative regulation of peptidyl-serine phosphorylation
0.58	GO:1902235	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.58	GO:1905898	positive regulation of response to endoplasmic reticulum stress
0.57	GO:0030032	lamellipodium assembly
0.57	GO:0042102	positive regulation of T cell proliferation

0.85	GO:0005070	SH3/SH2 adaptor activity
0.55	GO:0097110	scaffold protein binding
0.55	GO:0001784	phosphotyrosine residue binding
0.50	GO:0032403	protein complex binding
0.44	GO:0071074	eukaryotic initiation factor eIF2 binding
0.42	GO:0030971	receptor tyrosine kinase binding
0.41	GO:0004860	protein kinase inhibitor activity
0.41	GO:0045296	cadherin binding
0.41	GO:0046875	ephrin receptor binding
0.39	GO:0019904	protein domain specific binding

0.52	GO:0012506	vesicle membrane
0.49	GO:0005783	endoplasmic reticulum
0.41	GO:0000164	protein phosphatase type 1 complex
0.39	GO:0005911	cell-cell junction
0.39	GO:0014069	postsynaptic density
0.37	GO:0005840	ribosome
0.35	GO:0005829	cytosol
0.32	GO:0005634	nucleus

sp|O43653|PSCA_HUMAN
Prostate stem cell antigen
Search

PSCA

0.92	Prostate stem cell antigen

0.81	GO:0099601	regulation of neurotransmitter receptor activity
0.80	GO:0070373	negative regulation of ERK1 and ERK2 cascade
0.44	GO:0006501	C-terminal protein lipidation

0.83

GO:0033130

acetylcholine receptor binding

0.54	GO:0005886	plasma membrane
0.46	GO:0070062	extracellular exosome
0.45	GO:0031225	anchored component of membrane
0.30	GO:0016021	integral component of membrane

sp|O43657|TSN6_HUMAN
Tetraspanin-6
Search

TSPAN6

0.58	Tetraspanin

0.60	GO:1901223	negative regulation of NIK/NF-kappaB signaling
0.60	GO:0039532	negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
0.46	GO:0007166	cell surface receptor signaling pathway
0.38	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.33	GO:0016032	viral process

0.35	GO:0004871	signal transducer activity
0.33	GO:0005515	protein binding

0.44	GO:0005887	integral component of plasma membrane
0.38	GO:0070062	extracellular exosome

sp|O43660|PLRG1_HUMAN
Pleiotropic regulator 1
Search

PLRG1

0.93	Pleiotropic regulator 1

0.78	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
0.72	GO:0034504	protein localization to nucleus
0.59	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
0.55	GO:0000398	mRNA splicing, via spliceosome
0.53	GO:0043066	negative regulation of apoptotic process
0.34	GO:0006468	protein phosphorylation

0.37	GO:0016905	myosin heavy chain kinase activity
0.35	GO:0005515	protein binding

0.81	GO:0005662	DNA replication factor A complex
0.79	GO:0071007	U2-type catalytic step 2 spliceosome
0.76	GO:0001650	fibrillar center
0.73	GO:0016607	nuclear speck
0.73	GO:0031965	nuclear membrane
0.60	GO:0071011	precatalytic spliceosome
0.60	GO:0000974	Prp19 complex
0.60	GO:0080008	Cul4-RING E3 ubiquitin ligase complex

0.37

EC:2.7.11.7

GO:0016905

sp|O43663|PRC1_HUMAN
Protein regulator of cytokinesis 1
Search

PRC1

0.91	Putative microtubule-associated protein essential for anaphase spindle elongation

0.83	GO:0001578	microtubule bundle formation
0.72	GO:0000910	cytokinesis
0.51	GO:0008284	positive regulation of cell proliferation
0.51	GO:0032465	regulation of cytokinesis
0.39	GO:0006904	vesicle docking involved in exocytosis
0.36	GO:0000022	mitotic spindle elongation
0.34	GO:0036211	protein modification process
0.33	GO:0044267	cellular protein metabolic process

0.74	GO:0008017	microtubule binding
0.54	GO:0019894	kinesin binding
0.51	GO:0019901	protein kinase binding
0.37	GO:0042802	identical protein binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.69	GO:0005856	cytoskeleton
0.53	GO:0070938	contractile ring
0.53	GO:0030496	midbody
0.43	GO:0005634	nucleus
0.42	GO:0044446	intracellular organelle part
0.36	GO:0099512	supramolecular fiber
0.34	GO:0005829	cytosol

sp|O43665|RGS10_HUMAN
Regulator of G-protein signaling 10
Search

RGS10

0.97	Regulator of G-protein signalling 10

0.73	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.55	GO:0050790	regulation of catalytic activity
0.55	GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
0.52	GO:0044093	positive regulation of molecular function
0.38	GO:0009968	negative regulation of signal transduction
0.33	GO:0071897	DNA biosynthetic process

0.77	GO:0001965	G-protein alpha-subunit binding
0.60	GO:0030695	GTPase regulator activity
0.53	GO:0008047	enzyme activator activity
0.52	GO:0005057	signal transducer activity, downstream of receptor
0.33	GO:0003723	RNA binding
0.33	GO:0003677	DNA binding
0.33	GO:0003887	DNA-directed DNA polymerase activity
0.32	GO:1901265	nucleoside phosphate binding
0.32	GO:0036094	small molecule binding

0.47	GO:0005829	cytosol
0.44	GO:0005634	nucleus
0.40	GO:0043197	dendritic spine
0.40	GO:0043679	axon terminus
0.39	GO:0005886	plasma membrane
0.39	GO:0043025	neuronal cell body
0.30	GO:0016021	integral component of membrane

0.33

GO:0003887

sp|O43670|ZN207_HUMAN
BUB3-interacting and GLEBS motif-containing protein ZNF207
Search

ZNF207

0.89	Zinc finger protein 207

0.55	GO:0090307	mitotic spindle assembly
0.53	GO:0008608	attachment of spindle microtubules to kinetochore
0.53	GO:0007094	mitotic spindle assembly checkpoint
0.50	GO:0050821	protein stabilization
0.50	GO:0000070	mitotic sister chromatid segregation

0.52	GO:0008201	heparin binding
0.51	GO:0003676	nucleic acid binding
0.50	GO:0008017	microtubule binding

0.57	GO:1990047	spindle matrix
0.51	GO:0000776	kinetochore
0.47	GO:0005730	nucleolus
0.46	GO:0005654	nucleoplasm

sp|O43674|NDUB5_HUMAN
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Search

NDUFB5

0.40	Mitochondrial NADH dehydrogenase 1 beta subcomplex subunit 5

0.55	GO:0032981	mitochondrial respiratory chain complex I assembly
0.37	GO:0055114	oxidation-reduction process
0.34	GO:0006119	oxidative phosphorylation
0.33	GO:0043044	ATP-dependent chromatin remodeling

0.37

GO:0008137

NADH dehydrogenase (ubiquinone) activity

0.54	GO:0005747	mitochondrial respiratory chain complex I
0.48	GO:0005654	nucleoplasm
0.33	GO:0071564	npBAF complex
0.30	GO:0016021	integral component of membrane

0.37

GO:0008137

sp|O43676|NDUB3_HUMAN
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
Search

NDUFB3

0.91	NADH:ubiquinone oxidoreductase subunit B3

0.81	GO:0032981	mitochondrial respiratory chain complex I assembly
0.61	GO:0022900	electron transport chain

0.82	GO:0005747	mitochondrial respiratory chain complex I
0.40	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

sp|O43677|NDUC1_HUMAN
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Search

NDUFC1

0.97	NADH dehydrogenase ubiquinone 1 subunit C1, mitochondrial

0.67	GO:0032981	mitochondrial respiratory chain complex I assembly
0.43	GO:0055114	oxidation-reduction process
0.38	GO:0006119	oxidative phosphorylation

0.39

GO:0008137

NADH dehydrogenase (ubiquinone) activity

0.82	GO:0005747	mitochondrial respiratory chain complex I
0.30	GO:0016021	integral component of membrane

0.39

GO:0008137

sp|O43678|NDUA2_HUMAN
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
Search

NDUFA2

0.96	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

0.60	GO:0032981	mitochondrial respiratory chain complex I assembly
0.52	GO:0055114	oxidation-reduction process
0.34	GO:0006119	oxidative phosphorylation

0.50

GO:0008137

NADH dehydrogenase (ubiquinone) activity

0.64	GO:0005747	mitochondrial respiratory chain complex I
0.33	GO:0005840	ribosome
0.30	GO:0016021	integral component of membrane

0.50

GO:0008137

sp|O43679|LDB2_HUMAN
LIM domain-binding protein 2
Search

LDB2

0.94	LIM domain-binding protein 2

0.70	GO:0006357	regulation of transcription by RNA polymerase II
0.54	GO:0010669	epithelial structure maintenance
0.54	GO:0035019	somatic stem cell population maintenance
0.51	GO:0001942	hair follicle development
0.50	GO:0030334	regulation of cell migration
0.50	GO:0044089	positive regulation of cellular component biogenesis
0.49	GO:0043549	regulation of kinase activity
0.48	GO:0045893	positive regulation of transcription, DNA-templated
0.40	GO:1900108	negative regulation of nodal signaling pathway
0.39	GO:0090288	negative regulation of cellular response to growth factor stimulus

0.86	GO:0030274	LIM domain binding
0.75	GO:0000989	transcription factor activity, transcription factor binding
0.47	GO:0019899	enzyme binding
0.38	GO:0003682	chromatin binding

0.61	GO:0005634	nucleus
0.51	GO:0031252	cell leading edge
0.49	GO:0005667	transcription factor complex
0.46	GO:0031974	membrane-enclosed lumen
0.43	GO:0043232	intracellular non-membrane-bounded organelle
0.42	GO:0044446	intracellular organelle part
0.41	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O43680|TCF21_HUMAN
Transcription factor 21
Search

TCF21

0.97	LOW QUALITY PROTEIN: transcription factor 21

0.68	GO:0014707	branchiomeric skeletal muscle development
0.66	GO:0060539	diaphragm development
0.63	GO:0060021	palate development
0.63	GO:0072277	metanephric glomerular capillary formation
0.63	GO:0060435	bronchiole development
0.63	GO:0072162	metanephric mesenchymal cell differentiation
0.62	GO:0060426	lung vasculature development
0.61	GO:0060766	negative regulation of androgen receptor signaling pathway
0.60	GO:0048286	lung alveolus development
0.60	GO:0001658	branching involved in ureteric bud morphogenesis

0.68	GO:0046983	protein dimerization activity
0.62	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.60	GO:0070888	E-box binding
0.59	GO:0043425	bHLH transcription factor binding
0.59	GO:0050681	androgen receptor binding
0.57	GO:0042826	histone deacetylase binding
0.57	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.48	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.47	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.34	GO:0003714	transcription corepressor activity

0.49	GO:0005634	nucleus
0.42	GO:0043233	organelle lumen
0.39	GO:0044446	intracellular organelle part

sp|O43681|ASNA_HUMAN
ATPase ASNA1
Search

ASNA1

0.66	Arsenical pump-driving ATPase

0.77	GO:0045048	protein insertion into ER membrane
0.45	GO:0007416	synapse assembly
0.35	GO:0036498	IRE1-mediated unfolded protein response
0.34	GO:0015700	arsenite transport

0.61	GO:0016887	ATPase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.52	GO:0046872	metal ion binding
0.34	GO:0015105	arsenite transmembrane transporter activity
0.33	GO:0005515	protein binding

0.70	GO:0005783	endoplasmic reticulum
0.48	GO:0005730	nucleolus
0.37	GO:0070062	extracellular exosome
0.34	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.33	GO:0031984	organelle subcompartment
0.30	GO:0044425	membrane part

0.61

GO:0016887

sp|O43683|BUB1_HUMAN
Mitotic checkpoint serine/threonine-protein kinase BUB1
Search

BUB1

0.92	Budding uninhibited by benzimidazoles 1 homolog

0.83	GO:0007094	mitotic spindle assembly checkpoint
0.63	GO:0006468	protein phosphorylation
0.60	GO:0007063	regulation of sister chromatid cohesion
0.54	GO:0051754	meiotic sister chromatid cohesion, centromeric
0.39	GO:0008283	cell proliferation
0.38	GO:0006915	apoptotic process
0.38	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
0.36	GO:0051301	cell division
0.35	GO:0016032	viral process
0.35	GO:0031134	sister chromatid biorientation

0.63	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005515	protein binding
0.32	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.32	GO:0005216	ion channel activity

0.59	GO:0000778	condensed nuclear chromosome kinetochore
0.57	GO:0000940	condensed chromosome outer kinetochore
0.51	GO:0005654	nucleoplasm
0.50	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.32

GO:0003899

sp|O43684|BUB3_HUMAN
Mitotic checkpoint protein BUB3
Search

BUB3

0.90	Mitotic checkpoint protein BUB3

0.78	GO:0008608	attachment of spindle microtubules to kinetochore
0.74	GO:0051983	regulation of chromosome segregation
0.71	GO:0000070	mitotic sister chromatid segregation
0.60	GO:0071173	spindle assembly checkpoint
0.60	GO:0045839	negative regulation of mitotic nuclear division
0.59	GO:2001251	negative regulation of chromosome organization
0.59	GO:1901991	negative regulation of mitotic cell cycle phase transition
0.59	GO:0007093	mitotic cell cycle checkpoint
0.48	GO:0051321	meiotic cell cycle
0.44	GO:0051301	cell division

0.60	GO:0043130	ubiquitin binding
0.38	GO:0043565	sequence-specific DNA binding

0.77	GO:0000776	kinetochore
0.66	GO:1990298	bub1-bub3 complex
0.65	GO:0005654	nucleoplasm
0.64	GO:0033597	mitotic checkpoint complex
0.49	GO:0000779	condensed chromosome, centromeric region
0.37	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O43688|PLPP2_HUMAN
Phospholipid phosphatase 2
Search

PLPP2

0.96	Lipid phosphate phosphohydrolase 2

0.68	GO:0016311	dephosphorylation
0.44	GO:0030258	lipid modification
0.42	GO:0006644	phospholipid metabolic process
0.40	GO:0007165	signal transduction
0.35	GO:0030148	sphingolipid biosynthetic process
0.33	GO:0006464	cellular protein modification process

0.85	GO:0008195	phosphatidate phosphatase activity
0.49	GO:0042577	lipid phosphatase activity
0.36	GO:0042392	sphingosine-1-phosphate phosphatase activity
0.34	GO:0004721	phosphoprotein phosphatase activity
0.33	GO:0005515	protein binding
0.33	GO:0003677	DNA binding

0.42	GO:0005887	integral component of plasma membrane
0.34	GO:0005634	nucleus

0.85

EC:3.1.3.4

GO:0008195

sp|O43692|PI15_HUMAN
Peptidase inhibitor 15
Search

PI15

0.97	Peptidase inhibitor 15-A

0.39	GO:0010466	negative regulation of peptidase activity
0.37	GO:0007275	multicellular organism development
0.33	GO:0006508	proteolysis

0.39	GO:0030414	peptidase inhibitor activity
0.33	GO:0008233	peptidase activity

0.61	GO:0005576	extracellular region
0.35	GO:0031982	vesicle
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0008233

sp|O43699|SIGL6_HUMAN
Sialic acid-binding Ig-like lectin 6
Search

0.93	Sialic acid binding Ig like lectin 6

0.41	GO:0007155	cell adhesion
0.39	GO:0043312	neutrophil degranulation
0.37	GO:0060101	negative regulation of phagocytosis, engulfment
0.37	GO:0006898	receptor-mediated endocytosis
0.37	GO:0048583	regulation of response to stimulus
0.37	GO:0007267	cell-cell signaling
0.36	GO:0002682	regulation of immune system process
0.35	GO:0007165	signal transduction
0.34	GO:0045087	innate immune response
0.34	GO:0008285	negative regulation of cell proliferation

0.49	GO:0030246	carbohydrate binding
0.41	GO:0033691	sialic acid binding
0.38	GO:0038024	cargo receptor activity
0.36	GO:0005515	protein binding
0.35	GO:0005057	signal transducer activity, downstream of receptor

0.44	GO:0009986	cell surface
0.41	GO:0098552	side of membrane
0.40	GO:0044459	plasma membrane part
0.39	GO:0030667	secretory granule membrane
0.38	GO:0070820	tertiary granule
0.38	GO:0005634	nucleus
0.37	GO:0101002	ficolin-1-rich granule
0.36	GO:0005576	extracellular region
0.35	GO:0042581	specific granule
0.30	GO:0031224	intrinsic component of membrane

sp|O43704|ST1B1_HUMAN
Sulfotransferase family cytosolic 1B member 1
Search

0.54	Sulfotransferase

0.69	GO:0042403	thyroid hormone metabolic process
0.67	GO:0051923	sulfation
0.62	GO:0006805	xenobiotic metabolic process
0.55	GO:0006068	ethanol catabolic process
0.54	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
0.52	GO:0009812	flavonoid metabolic process
0.48	GO:0030855	epithelial cell differentiation
0.43	GO:0008202	steroid metabolic process
0.40	GO:0006584	catecholamine metabolic process
0.36	GO:0000103	sulfate assimilation

0.77	GO:0008146	sulfotransferase activity
0.35	GO:0005515	protein binding
0.34	GO:0005496	steroid binding

0.38	GO:0005829	cytosol
0.35	GO:0031965	nuclear membrane

0.77

GO:0008146

sp|O43707|ACTN4_HUMAN
Alpha-actinin-4
Search

ACTN4

0.66	Eukaryotic translation initiation factor 3 subunit K

0.60	GO:0051017	actin filament bundle assembly
0.55	GO:0051764	actin crosslink formation
0.55	GO:1902396	protein localization to bicellular tight junction
0.54	GO:0035357	peroxisome proliferator activated receptor signaling pathway
0.53	GO:0048549	positive regulation of pinocytosis
0.53	GO:0030050	vesicle transport along actin filament
0.52	GO:0048384	retinoic acid receptor signaling pathway
0.52	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
0.52	GO:0034329	cell junction assembly
0.51	GO:0045216	cell-cell junction organization

0.72	GO:0003779	actin binding
0.69	GO:0005509	calcium ion binding
0.56	GO:0032403	protein complex binding
0.54	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
0.53	GO:0044325	ion channel binding
0.53	GO:0042803	protein homodimerization activity
0.52	GO:0042974	retinoic acid receptor binding
0.50	GO:0031490	chromatin DNA binding
0.50	GO:0017166	vinculin binding
0.48	GO:0051393	alpha-actinin binding

0.58	GO:0097517	contractile actin filament bundle
0.57	GO:0042641	actomyosin
0.55	GO:0044449	contractile fiber part
0.55	GO:0030863	cortical cytoskeleton
0.53	GO:0005911	cell-cell junction
0.52	GO:0005903	brush border
0.52	GO:0031143	pseudopodium
0.51	GO:0030016	myofibril
0.49	GO:0016604	nuclear body
0.49	GO:0097433	dense body

sp|O43708|MAAI_HUMAN
Maleylacetoacetate isomerase
Search

GSTZ1

0.72	Glutathione S-transferase zeta 1

0.69

GO:0009072

aromatic amino acid family metabolic process

0.45	GO:0004364	glutathione transferase activity
0.40	GO:0016853	isomerase activity

0.49	GO:0005737	cytoplasm
0.45	GO:0043231	intracellular membrane-bounded organelle

0.45

EC:2.5.1.18

GO:0004364

sp|O43709|WBS22_HUMAN
Probable 18S rRNA (guanine-N(7))-methyltransferase
Search

BUD23

0.95	BUD23, rRNA methyltransferase and ribosome maturation factor

0.79	GO:0070476	rRNA (guanine-N7)-methylation
0.73	GO:2000234	positive regulation of rRNA processing

0.77	GO:0016435	rRNA (guanine) methyltransferase activity
0.62	GO:0046982	protein heterodimerization activity

0.65	GO:0048471	perinuclear region of cytoplasm
0.62	GO:0005730	nucleolus
0.59	GO:0005654	nucleoplasm

0.77

GO:0016435

sp|O43711|TLX3_HUMAN
T-cell leukemia homeobox protein 3
Search

TLX3

0.96	T-cell leukemia homeobox protein 3

0.57	GO:0002087	regulation of respiratory gaseous exchange by neurological system process
0.56	GO:0007585	respiratory gaseous exchange
0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0048665	neuron fate specification
0.55	GO:0010468	regulation of gene expression
0.54	GO:0001764	neuron migration
0.54	GO:0045665	negative regulation of neuron differentiation
0.51	GO:0007417	central nervous system development
0.42	GO:0048839	inner ear development

0.63	GO:0043565	sequence-specific DNA binding
0.42	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.41	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.40	GO:0001012	RNA polymerase II regulatory region DNA binding
0.39	GO:0003690	double-stranded DNA binding
0.35	GO:0005515	protein binding
0.33	GO:0005198	structural molecule activity

0.60	GO:0005634	nucleus
0.47	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part
0.34	GO:0045111	intermediate filament cytoskeleton
0.34	GO:0099512	supramolecular fiber

sp|O43715|TRIA1_HUMAN
TP53-regulated inhibitor of apoptosis 1
Search

TRIAP1

0.97	LOW QUALITY PROTEIN: TP53-regulated inhibitor of apoptosis 1

0.79	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.77	GO:2001140	positive regulation of phospholipid transport
0.76	GO:0090201	negative regulation of release of cytochrome c from mitochondria
0.74	GO:0030330	DNA damage response, signal transduction by p53 class mediator
0.72	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.72	GO:0015914	phospholipid transport
0.71	GO:0034644	cellular response to UV
0.71	GO:0097035	regulation of membrane lipid distribution
0.65	GO:0045944	positive regulation of transcription by RNA polymerase II
0.47	GO:0048793	pronephros development

0.77	GO:1990050	phosphatidic acid transporter activity
0.72	GO:0002039	p53 binding

0.76	GO:0005758	mitochondrial intermembrane space
0.60	GO:0005654	nucleoplasm
0.53	GO:0043234	protein complex
0.47	GO:0048471	perinuclear region of cytoplasm

sp|O43716|GATC_HUMAN
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
Search

GATC

0.93	Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

0.80	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation
0.76	GO:0032543	mitochondrial translation
0.72	GO:0006450	regulation of translational fidelity
0.34	GO:0006260	DNA replication
0.34	GO:0006281	DNA repair
0.33	GO:0007017	microtubule-based process
0.33	GO:1902600	hydrogen ion transmembrane transport
0.33	GO:0055114	oxidation-reduction process
0.33	GO:0006091	generation of precursor metabolites and energy

0.73	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0016740	transferase activity
0.34	GO:0005515	protein binding
0.33	GO:0015002	heme-copper terminal oxidase activity
0.33	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.33	GO:0015078	hydrogen ion transmembrane transporter activity
0.33	GO:0009055	electron transfer activity

0.73	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex
0.58	GO:0005739	mitochondrion
0.34	GO:0045277	respiratory chain complex IV
0.34	GO:0030286	dynein complex
0.33	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.73

EC:6.3.5.7

GO:0050567

sp|O43719|HTSF1_HUMAN
HIV Tat-specific factor 1
Search

HTATSF1

0.83	HIV Tat-specific factor 1

0.74	GO:0000398	mRNA splicing, via spliceosome
0.35	GO:0006414	translational elongation
0.34	GO:0006351	transcription, DNA-templated
0.34	GO:1903506	regulation of nucleic acid-templated transcription
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression
0.33	GO:0007186	G-protein coupled receptor signaling pathway
0.32	GO:0019079	viral genome replication

0.59	GO:0003723	RNA binding
0.34	GO:0008528	G-protein coupled peptide receptor activity
0.32	GO:0043565	sequence-specific DNA binding
0.32	GO:0008270	zinc ion binding
0.32	GO:0003700	DNA binding transcription factor activity

0.48	GO:0044428	nuclear part
0.46	GO:0120114	Sm-like protein family complex
0.46	GO:0031974	membrane-enclosed lumen
0.40	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0031224	intrinsic component of membrane

sp|O43731|ERD23_HUMAN
ER lumen protein-retaining receptor 3
Search

KDELR3

0.67	ER lumen protein-retaining receptor

0.83	GO:0006621	protein retention in ER lumen
0.65	GO:0015031	protein transport
0.38	GO:0016192	vesicle-mediated transport
0.35	GO:0036498	IRE1-mediated unfolded protein response
0.33	GO:0006629	lipid metabolic process

0.84	GO:0046923	ER retention sequence binding
0.32	GO:0016787	hydrolase activity

0.71	GO:0005789	endoplasmic reticulum membrane
0.34	GO:0030133	transport vesicle
0.34	GO:0000139	Golgi membrane
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0016787

sp|O43734|CIKS_HUMAN
Adapter protein CIKS
Search

TRAF3IP2

0.93	Adapter protein CIKS

0.87	GO:0048305	immunoglobulin secretion
0.87	GO:0001783	B cell apoptotic process
0.86	GO:0002230	positive regulation of defense response to virus by host
0.84	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.82	GO:0006959	humoral immune response
0.51	GO:0035556	intracellular signal transduction

0.72

GO:0005102

receptor binding

0.40

GO:0005622

intracellular

sp|O43736|ITM2A_HUMAN
Integral membrane protein 2A
Search

ITM2A

0.43	Integral membrane protein 2A variant 2

0.59	GO:0002317	plasma cell differentiation
0.58	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process
0.55	GO:0002377	immunoglobulin production
0.46	GO:0007399	nervous system development
0.35	GO:0038034	signal transduction in absence of ligand
0.35	GO:0097191	extrinsic apoptotic signaling pathway
0.32	GO:0044267	cellular protein metabolic process

0.55	GO:0001540	amyloid-beta binding
0.37	GO:0032559	adenyl ribonucleotide binding
0.37	GO:0008144	drug binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding

0.49	GO:0005615	extracellular space
0.49	GO:1903561	extracellular vesicle
0.48	GO:0005794	Golgi apparatus
0.45	GO:0030660	Golgi-associated vesicle membrane
0.44	GO:0031301	integral component of organelle membrane
0.41	GO:0005886	plasma membrane
0.38	GO:0010008	endosome membrane
0.36	GO:0031984	organelle subcompartment

sp|O43739|CYH3_HUMAN
Cytohesin-3
Search

CYTH3

0.96	Putative pattern-formation protein/guanine nucleotide exchange factor (Fragment)

0.81	GO:0032012	regulation of ARF protein signal transduction
0.66	GO:0065009	regulation of molecular function
0.54	GO:0090162	establishment of epithelial cell polarity
0.51	GO:0030155	regulation of cell adhesion
0.49	GO:0048193	Golgi vesicle transport
0.46	GO:0048518	positive regulation of biological process

0.82	GO:0005086	ARF guanyl-nucleotide exchange factor activity
0.54	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding

0.52	GO:0001726	ruffle
0.52	GO:0005923	bicellular tight junction
0.51	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.51	GO:0005912	adherens junction
0.46	GO:0005829	cytosol
0.46	GO:0005654	nucleoplasm
0.34	GO:0000139	Golgi membrane

sp|O43741|AAKB2_HUMAN
5'-AMP-activated protein kinase subunit beta-2
Search

PRKAB2

0.97	5'-AMP-activated protein kinase beta-2 non-catalytic subunit transcript variant 2

0.56	GO:0016310	phosphorylation
0.45	GO:0036211	protein modification process
0.44	GO:0035878	nail development
0.43	GO:0044267	cellular protein metabolic process
0.40	GO:0010628	positive regulation of gene expression
0.37	GO:0006633	fatty acid biosynthetic process
0.36	GO:0006853	carnitine shuttle
0.35	GO:1901796	regulation of signal transduction by p53 class mediator
0.35	GO:0042304	regulation of fatty acid biosynthetic process
0.35	GO:0016241	regulation of macroautophagy

0.58	GO:0016301	kinase activity
0.49	GO:0042802	identical protein binding
0.46	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.45	GO:0060089	molecular transducer activity
0.44	GO:0140096	catalytic activity, acting on a protein
0.34	GO:0019901	protein kinase binding

0.55	GO:0031588	nucleotide-activated protein kinase complex
0.39	GO:0005634	nucleus
0.36	GO:0043233	organelle lumen
0.35	GO:0005829	cytosol
0.35	GO:0005952	cAMP-dependent protein kinase complex
0.35	GO:0016324	apical plasma membrane
0.34	GO:0044446	intracellular organelle part

0.46

GO:0016773

sp|O43745|CHP2_HUMAN
Calcineurin B homologous protein 2
Search

CHP1

0.53	Calcium-binding protein CHP

0.57	GO:0070884	regulation of calcineurin-NFAT signaling cascade
0.55	GO:0042306	regulation of protein import into nucleus
0.52	GO:0051050	positive regulation of transport
0.52	GO:0010921	regulation of phosphatase activity
0.52	GO:0106058	positive regulation of calcineurin-mediated signaling
0.50	GO:0071277	cellular response to calcium ion
0.50	GO:0044093	positive regulation of molecular function
0.50	GO:1904951	positive regulation of establishment of protein localization
0.50	GO:0035306	positive regulation of dephosphorylation
0.49	GO:1900182	positive regulation of protein localization to nucleus

0.70	GO:0005509	calcium ion binding
0.47	GO:0048306	calcium-dependent protein binding
0.38	GO:0004860	protein kinase inhibitor activity
0.38	GO:0019900	kinase binding
0.37	GO:0008017	microtubule binding
0.35	GO:0005215	transporter activity
0.34	GO:0015459	potassium channel regulator activity
0.34	GO:0019904	protein domain specific binding

0.42	GO:0005634	nucleus
0.42	GO:0005886	plasma membrane
0.38	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.38	GO:0030133	transport vesicle
0.37	GO:0000139	Golgi membrane
0.37	GO:0015630	microtubule cytoskeleton
0.37	GO:0005783	endoplasmic reticulum
0.35	GO:0005829	cytosol
0.35	GO:0005925	focal adhesion
0.35	GO:0070062	extracellular exosome

sp|O43747|AP1G1_HUMAN
AP-1 complex subunit gamma-1
Search

AP1G1

0.83	AP-1 complex subunit gamma-1

0.68	GO:0006886	intracellular protein transport
0.67	GO:0016192	vesicle-mediated transport
0.59	GO:0043323	positive regulation of natural killer cell degranulation
0.58	GO:0035646	endosome to melanosome transport
0.55	GO:0007041	lysosomal transport
0.53	GO:0016482	cytosolic transport
0.46	GO:0033339	pectoral fin development
0.36	GO:0016050	vesicle organization
0.36	GO:0099532	synaptic vesicle endosomal processing
0.35	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

0.57	GO:0030742	GTP-dependent protein binding
0.55	GO:0019894	kinesin binding
0.53	GO:0017137	Rab GTPase binding
0.35	GO:0008022	protein C-terminus binding
0.35	GO:0005518	collagen binding
0.33	GO:0003735	structural constituent of ribosome
0.33	GO:0005215	transporter activity

0.77	GO:0030131	clathrin adaptor complex
0.69	GO:0005794	Golgi apparatus
0.54	GO:0055037	recycling endosome
0.53	GO:0030136	clathrin-coated vesicle
0.47	GO:0005829	cytosol
0.37	GO:0030662	coated vesicle membrane
0.36	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0031984	organelle subcompartment
0.35	GO:0005765	lysosomal membrane
0.34	GO:0045202	synapse

sp|O43749|OR1F1_HUMAN
Olfactory receptor 1F1
Search

0.45	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O43752|STX6_HUMAN
Syntaxin-6
Search

STX6

0.91	Syntaxin 6

0.75	GO:0048193	Golgi vesicle transport
0.68	GO:0006886	intracellular protein transport
0.67	GO:0061025	membrane fusion
0.58	GO:0090161	Golgi ribbon formation
0.57	GO:0042147	retrograde transport, endosome to Golgi
0.56	GO:0048284	organelle fusion
0.55	GO:0032456	endocytic recycling
0.55	GO:0007032	endosome organization
0.53	GO:0032880	regulation of protein localization
0.51	GO:0060341	regulation of cellular localization

0.79	GO:0005484	SNAP receptor activity
0.58	GO:0000149	SNARE binding

0.57	GO:0031201	SNARE complex
0.56	GO:0032588	trans-Golgi network membrane
0.56	GO:0048471	perinuclear region of cytoplasm
0.54	GO:0045335	phagocytic vesicle
0.54	GO:0005769	early endosome
0.50	GO:0005829	cytosol
0.49	GO:0005654	nucleoplasm
0.39	GO:0030285	integral component of synaptic vesicle membrane
0.38	GO:0043195	terminal bouton
0.36	GO:0055037	recycling endosome

sp|O43759|SNG1_HUMAN
Synaptogyrin-1
Search

SYNGR1

0.87	Putative synaptic vesicle protein synaptogyrin involved in regulation of ca2+-dependent exocytosis

0.51	GO:0048172	regulation of short-term neuronal synaptic plasticity
0.51	GO:0048169	regulation of long-term neuronal synaptic plasticity
0.49	GO:1990830	cellular response to leukemia inhibitory factor
0.42	GO:0045055	regulated exocytosis
0.42	GO:0048499	synaptic vesicle membrane organization
0.40	GO:0060976	coronary vasculature development
0.39	GO:0035904	aorta development
0.39	GO:0000185	activation of MAPKKK activity
0.39	GO:0006470	protein dephosphorylation
0.39	GO:0003279	cardiac septum development

0.40	GO:0004722	protein serine/threonine phosphatase activity
0.39	GO:0019209	kinase activator activity
0.38	GO:0042169	SH2 domain binding
0.38	GO:0047485	protein N-terminus binding
0.35	GO:0016301	kinase activity
0.33	GO:0003735	structural constituent of ribosome
0.33	GO:0003723	RNA binding

0.49	GO:0030672	synaptic vesicle membrane
0.49	GO:0031594	neuromuscular junction
0.40	GO:0042470	melanosome
0.39	GO:0043195	terminal bouton
0.38	GO:0030054	cell junction
0.37	GO:0016607	nuclear speck
0.36	GO:0035577	azurophil granule membrane
0.36	GO:0005829	cytosol
0.33	GO:0005840	ribosome
0.33	GO:0005886	plasma membrane

sp|O43760|SNG2_HUMAN
Synaptogyrin-2
Search

SYNGR2

0.87	Synaptogyrin

0.45	GO:0045055	regulated exocytosis
0.42	GO:0032411	positive regulation of transporter activity
0.42	GO:0048499	synaptic vesicle membrane organization
0.39	GO:0048172	regulation of short-term neuronal synaptic plasticity
0.39	GO:0048169	regulation of long-term neuronal synaptic plasticity
0.39	GO:0071310	cellular response to organic substance
0.39	GO:1990823	response to leukemia inhibitory factor
0.37	GO:0060976	coronary vasculature development
0.37	GO:0035904	aorta development
0.37	GO:0000185	activation of MAPKKK activity

0.43	GO:0042169	SH2 domain binding
0.43	GO:0047485	protein N-terminus binding
0.37	GO:0004722	protein serine/threonine phosphatase activity
0.37	GO:0019209	kinase activator activity
0.33	GO:0016972	thiol oxidase activity
0.32	GO:0016301	kinase activity

0.58	GO:0008021	synaptic vesicle
0.51	GO:0031594	neuromuscular junction
0.50	GO:0099501	exocytic vesicle membrane
0.40	GO:0030054	cell junction
0.37	GO:0070062	extracellular exosome
0.36	GO:0016607	nuclear speck
0.35	GO:0005811	lipid droplet
0.35	GO:0005829	cytosol
0.33	GO:0005739	mitochondrion
0.30	GO:0031224	intrinsic component of membrane

0.33

EC:1.8.3.2

GO:0016972

sp|O43761|SNG3_HUMAN
Synaptogyrin-3
Search

SYNGR3

0.62	Sulfhydryl oxidase

0.53	GO:0045055	regulated exocytosis
0.53	GO:0032411	positive regulation of transporter activity
0.44	GO:0048172	regulation of short-term neuronal synaptic plasticity
0.44	GO:0048169	regulation of long-term neuronal synaptic plasticity
0.43	GO:1990830	cellular response to leukemia inhibitory factor
0.39	GO:0048499	synaptic vesicle membrane organization
0.38	GO:0021762	substantia nigra development
0.37	GO:0060976	coronary vasculature development
0.37	GO:0035904	aorta development
0.37	GO:0000185	activation of MAPKKK activity

0.55	GO:0042169	SH2 domain binding
0.54	GO:0047485	protein N-terminus binding
0.37	GO:0004722	protein serine/threonine phosphatase activity
0.37	GO:0016972	thiol oxidase activity
0.37	GO:0019209	kinase activator activity
0.33	GO:0016301	kinase activity
0.32	GO:0003735	structural constituent of ribosome
0.32	GO:0003723	RNA binding

0.58	GO:0031594	neuromuscular junction
0.57	GO:0008021	synaptic vesicle
0.52	GO:0099501	exocytic vesicle membrane
0.40	GO:0030054	cell junction
0.38	GO:0042470	melanosome
0.37	GO:0043195	terminal bouton
0.35	GO:0016607	nuclear speck
0.35	GO:0035577	azurophil granule membrane
0.34	GO:0005829	cytosol
0.32	GO:0005840	ribosome

0.37

EC:1.8.3.2

GO:0016972

sp|O43763|TLX2_HUMAN
T-cell leukemia homeobox protein 2
Search

0.93	T-cell leukemia homeobox protein 2

0.61	GO:0045665	negative regulation of neuron differentiation
0.59	GO:2000171	negative regulation of dendrite development
0.58	GO:0048484	enteric nervous system development
0.57	GO:0010771	negative regulation of cell morphogenesis involved in differentiation
0.57	GO:0001707	mesoderm formation
0.57	GO:0048814	regulation of dendrite morphogenesis
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:0010468	regulation of gene expression
0.56	GO:0031345	negative regulation of cell projection organization

0.64	GO:0043565	sequence-specific DNA binding
0.56	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.39	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.38	GO:0001012	RNA polymerase II regulatory region DNA binding
0.37	GO:0003690	double-stranded DNA binding
0.35	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.43	GO:0043233	organelle lumen
0.40	GO:0044446	intracellular organelle part
0.39	GO:0005737	cytoplasm

sp|O43765|SGTA_HUMAN
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Search

SGTA

0.95	Kidney epithelial small glutamine rich tricopeptide-containing protein alpha

0.86	GO:1903070	negative regulation of ER-associated ubiquitin-dependent protein catabolic process
0.86	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process
0.85	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.78	GO:0030433	ubiquitin-dependent ERAD pathway
0.37	GO:0006260	DNA replication
0.36	GO:0016032	viral process
0.36	GO:0006457	protein folding
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:0006355	regulation of transcription, DNA-templated

0.86	GO:1904288	BAT3 complex binding
0.82	GO:0043621	protein self-association
0.40	GO:0042803	protein homodimerization activity
0.40	GO:0046982	protein heterodimerization activity
0.38	GO:0030544	Hsp70 protein binding
0.38	GO:0008022	protein C-terminus binding
0.37	GO:0051087	chaperone binding
0.36	GO:0003700	DNA binding transcription factor activity
0.35	GO:0003677	DNA binding

0.66	GO:0005829	cytosol
0.60	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|O43766|LIAS_HUMAN
Lipoyl synthase, mitochondrial
Search

LIAS

0.71	Lipoyl synthase, mitochondrial

0.78	GO:0009107	lipoate biosynthetic process
0.71	GO:0009249	protein lipoylation
0.56	GO:0001843	neural tube closure
0.55	GO:0032496	response to lipopolysaccharide
0.54	GO:0006954	inflammatory response
0.49	GO:0006979	response to oxidative stress
0.33	GO:0006260	DNA replication
0.32	GO:0055085	transmembrane transport
0.32	GO:0055114	oxidation-reduction process
0.32	GO:0005975	carbohydrate metabolic process

0.79	GO:0016992	lipoate synthase activity
0.66	GO:0051539	4 iron, 4 sulfur cluster binding
0.51	GO:0046872	metal ion binding
0.34	GO:0061731	ribonucleoside-diphosphate reductase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0032553	ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0022857	transmembrane transporter activity
0.32	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds

0.58	GO:0005739	mitochondrion
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:2.8.1.8

GO:0016992

sp|O43768|ENSA_HUMAN
Alpha-endosulfine
Search

ENSA

0.94	Endosulfine alpha b

0.82	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.66	GO:0051301	cell division
0.66	GO:0007049	cell cycle
0.52	GO:0050796	regulation of insulin secretion
0.38	GO:0045722	positive regulation of gluconeogenesis
0.38	GO:0009749	response to glucose
0.35	GO:0007584	response to nutrient
0.34	GO:0046326	positive regulation of glucose import
0.34	GO:0046579	positive regulation of Ras protein signal transduction
0.34	GO:0007212	dopamine receptor signaling pathway

0.82	GO:0004864	protein phosphatase inhibitor activity
0.56	GO:0019870	potassium channel inhibitor activity
0.49	GO:0005102	receptor binding
0.47	GO:0051721	protein phosphatase 2A binding
0.34	GO:0019901	protein kinase binding

0.48	GO:0005737	cytoplasm
0.35	GO:0005654	nucleoplasm

sp|O43772|MCAT_HUMAN
Mitochondrial carnitine/acylcarnitine carrier protein
Search

SLC25A20

0.80	Carnitine/acylcarnitine translocase

0.51	GO:1902603	carnitine transmembrane transport
0.47	GO:0006839	mitochondrial transport
0.39	GO:1902616	acyl carnitine transmembrane transport
0.35	GO:1902001	fatty acid transmembrane transport
0.35	GO:0032365	intracellular lipid transport
0.35	GO:0015909	long-chain fatty acid transport
0.32	GO:0006518	peptide metabolic process
0.32	GO:0043604	amide biosynthetic process
0.32	GO:0016310	phosphorylation
0.32	GO:0044267	cellular protein metabolic process

0.51	GO:0005476	carnitine:acyl carnitine antiporter activity
0.51	GO:0015226	carnitine transmembrane transporter activity
0.39	GO:0015227	acyl carnitine transmembrane transporter activity
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0016301	kinase activity

0.48	GO:0005829	cytosol
0.47	GO:0031966	mitochondrial membrane
0.47	GO:0019866	organelle inner membrane
0.32	GO:0005840	ribosome
0.30	GO:0031224	intrinsic component of membrane

sp|O43776|SYNC_HUMAN
Asparagine--tRNA ligase, cytoplasmic
Search

NARS

0.73	Asparaginyl-tRNA synthetase

0.78	GO:0006421	asparaginyl-tRNA aminoacylation
0.35	GO:0006783	heme biosynthetic process
0.33	GO:0045332	phospholipid translocation

0.78	GO:0004816	asparagine-tRNA ligase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0003676	nucleic acid binding
0.35	GO:0004325	ferrochelatase activity
0.33	GO:0004012	phospholipid-translocating ATPase activity
0.32	GO:0000287	magnesium ion binding

0.48	GO:0005737	cytoplasm
0.40	GO:0043231	intracellular membrane-bounded organelle
0.39	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.78	EC:6.1.1.22	GO:0004816
0.78	KEGG:R03648	GO:0004816

sp|O43781|DYRK3_HUMAN
Dual specificity tyrosine-phosphorylation-regulated kinase 3
Search

DYRK3

0.97	Dual specificity tyrosine-phosphorylation-regulated kinase 3

0.63	GO:0006468	protein phosphorylation
0.60	GO:0035617	stress granule disassembly
0.57	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
0.56	GO:0030218	erythrocyte differentiation
0.56	GO:1903432	regulation of TORC1 signaling
0.52	GO:0043066	negative regulation of apoptotic process
0.46	GO:0051534	negative regulation of NFAT protein import into nucleus
0.45	GO:0045725	positive regulation of glycogen biosynthetic process
0.45	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.44	GO:0018212	peptidyl-tyrosine modification

0.64	GO:0004672	protein kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0000287	magnesium ion binding
0.41	GO:0030145	manganese ion binding
0.33	GO:0005515	protein binding

0.55	GO:0010494	cytoplasmic stress granule
0.51	GO:0005654	nucleoplasm
0.50	GO:0005829	cytosol
0.42	GO:0000151	ubiquitin ligase complex

sp|O43790|KRT86_HUMAN
Keratin, type II cuticular Hb6
Search

0.86	Keratin, type II cuticular Hb6

0.50	GO:0070268	cornification
0.40	GO:0042633	hair cycle
0.39	GO:0007568	aging
0.35	GO:0006811	ion transport

0.62	GO:0005198	structural molecule activity
0.40	GO:0005515	protein binding

0.83	GO:0045095	keratin filament
0.45	GO:0005615	extracellular space
0.43	GO:0005829	cytosol
0.39	GO:1903561	extracellular vesicle
0.30	GO:0031224	intrinsic component of membrane

sp|O43791|SPOP_HUMAN
Speckle-type POZ protein
Search

SPOP

0.89	Speckle type BTB/POZ protein

0.84	GO:2000676	positive regulation of type B pancreatic cell apoptotic process
0.82	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.78	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.76	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.75	GO:0043433	negative regulation of DNA binding transcription factor activity
0.73	GO:0042593	glucose homeostasis
0.70	GO:0000122	negative regulation of transcription by RNA polymerase II
0.60	GO:0031397	negative regulation of protein ubiquitination
0.54	GO:0030162	regulation of proteolysis

0.75	GO:0001085	RNA polymerase II transcription factor binding
0.73	GO:0031625	ubiquitin protein ligase binding

0.83	GO:0031463	Cul3-RING ubiquitin ligase complex
0.72	GO:0016607	nuclear speck
0.59	GO:0019005	SCF ubiquitin ligase complex
0.40	GO:0005737	cytoplasm

sp|O43795|MYO1B_HUMAN
Unconventional myosin-Ib
Search

MYO1B

0.76	Unconventional myosin-Ib

0.73	GO:0007018	microtubule-based movement
0.49	GO:0006892	post-Golgi vesicle-mediated transport
0.46	GO:0007015	actin filament organization
0.43	GO:0033572	transferrin transport
0.42	GO:0030048	actin filament-based movement
0.40	GO:0007399	nervous system development
0.38	GO:0022607	cellular component assembly

0.74	GO:0003777	microtubule motor activity
0.73	GO:0008017	microtubule binding
0.73	GO:0003779	actin binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.51	GO:0000146	microfilament motor activity
0.48	GO:0045296	cadherin binding
0.46	GO:0032403	protein complex binding
0.43	GO:0030898	actin-dependent ATPase activity

0.77	GO:0016459	myosin complex
0.50	GO:0032588	trans-Golgi network membrane
0.49	GO:0005884	actin filament
0.48	GO:0005769	early endosome
0.48	GO:0048471	perinuclear region of cytoplasm
0.47	GO:0010008	endosome membrane
0.42	GO:0030175	filopodium
0.42	GO:0005903	brush border
0.41	GO:0070062	extracellular exosome
0.41	GO:0045177	apical part of cell

sp|O43805|SSNA1_HUMAN
Sjoegren syndrome nuclear autoantigen 1
Search

SSNA1

0.96	Sjoegren syndrome nuclear autoantigen 1

0.87	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway
0.83	GO:0042073	intraciliary transport
0.44	GO:0097711	ciliary basal body-plasma membrane docking
0.42	GO:0000086	G2/M transition of mitotic cell cycle
0.42	GO:0010389	regulation of G2/M transition of mitotic cell cycle

0.73

GO:0042802

identical protein binding

0.82	GO:0036064	ciliary basal body
0.77	GO:0005813	centrosome
0.42	GO:0005634	nucleus
0.39	GO:0005829	cytosol
0.36	GO:0005886	plasma membrane

sp|O43808|PM34_HUMAN
Peroxisomal membrane protein PMP34
Search

SLC25A17

0.93	Solute carrier family 25 (Mitochondrial carrier peroxisomal membrane protein, 34kDa), member 17

0.77	GO:0035352	NAD transmembrane transport
0.77	GO:0080121	AMP transport
0.76	GO:0035350	FAD transmembrane transport
0.76	GO:0071106	adenosine 3',5'-bisphosphate transmembrane transport
0.76	GO:0015880	coenzyme A transport
0.72	GO:0015866	ADP transport
0.71	GO:0015867	ATP transport
0.68	GO:0015908	fatty acid transport
0.65	GO:0006635	fatty acid beta-oxidation
0.53	GO:0006839	mitochondrial transport

0.79	GO:0044610	FMN transmembrane transporter activity
0.77	GO:0051724	NAD transmembrane transporter activity
0.77	GO:0080122	AMP transmembrane transporter activity
0.77	GO:0015230	FAD transmembrane transporter activity
0.76	GO:0071077	adenosine 3',5'-bisphosphate transmembrane transporter activity
0.72	GO:0015217	ADP transmembrane transporter activity
0.72	GO:0005347	ATP transmembrane transporter activity
0.65	GO:0051087	chaperone binding

0.69	GO:0005779	integral component of peroxisomal membrane
0.54	GO:0005739	mitochondrion
0.46	GO:0031967	organelle envelope

sp|O43809|CPSF5_HUMAN
Cleavage and polyadenylation specificity factor subunit 5
Search

NUDT21

0.86	Nudix (Nucleoside diphosphate linked moiety X)-type motif 21

0.81	GO:0006378	mRNA polyadenylation
0.76	GO:0031439	positive regulation of mRNA cleavage
0.76	GO:1900365	positive regulation of mRNA polyadenylation
0.72	GO:0051290	protein heterotetramerization
0.70	GO:0098789	pre-mRNA cleavage required for polyadenylation

0.76	GO:0003729	mRNA binding
0.70	GO:0017091	AU-rich element binding
0.69	GO:0042826	histone deacetylase binding
0.62	GO:0003682	chromatin binding
0.62	GO:0042803	protein homodimerization activity
0.51	GO:0016787	hydrolase activity

0.81	GO:0005849	mRNA cleavage factor complex
0.73	GO:0042382	paraspeckles
0.64	GO:0005813	centrosome
0.43	GO:0005737	cytoplasm

0.51

GO:0016787

sp|O43812|DUX1_HUMAN
Double homeobox protein 1
Search

0.92	Double homeobox protein 1

0.47	GO:2001141	regulation of RNA biosynthetic process
0.47	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.46	GO:0010468	regulation of gene expression
0.41	GO:0051254	positive regulation of RNA metabolic process
0.40	GO:0009790	embryo development
0.40	GO:0010557	positive regulation of macromolecule biosynthetic process
0.40	GO:0031328	positive regulation of cellular biosynthetic process
0.40	GO:0009888	tissue development
0.40	GO:0048646	anatomical structure formation involved in morphogenesis
0.40	GO:0006351	transcription, DNA-templated

0.55	GO:0003677	DNA binding
0.39	GO:0001067	regulatory region nucleic acid binding
0.39	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.37	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.36	GO:0005515	protein binding
0.32	GO:0004725	protein tyrosine phosphatase activity

0.61	GO:0005634	nucleus
0.38	GO:0005794	Golgi apparatus
0.38	GO:0043233	organelle lumen
0.37	GO:0005829	cytosol
0.36	GO:0043232	intracellular non-membrane-bounded organelle
0.36	GO:0044446	intracellular organelle part
0.35	GO:0031090	organelle membrane
0.35	GO:0031975	envelope
0.33	GO:0005667	transcription factor complex
0.30	GO:0031224	intrinsic component of membrane

0.32

GO:0004725

sp|O43813|LANC1_HUMAN
LanC-like protein 1
Search

LANCL1

0.96	LanC lantibiotic synthetase component C-like 1 (Bacterial)

0.48

GO:0007165

signal transduction

0.85	GO:0050750	low-density lipoprotein particle receptor binding
0.84	GO:0043295	glutathione binding
0.78	GO:0017124	SH3 domain binding
0.62	GO:0008270	zinc ion binding

0.45

GO:0005886

plasma membrane

sp|O43815|STRN_HUMAN
Striatin
Search

STRN

0.96

Striatin

0.76	GO:0008285	negative regulation of cell proliferation
0.74	GO:0016055	Wnt signaling pathway
0.44	GO:0016358	dendrite development
0.43	GO:0007626	locomotory behavior
0.40	GO:0070830	bicellular tight junction assembly
0.34	GO:0000187	activation of MAPK activity
0.34	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.34	GO:0048666	neuron development
0.34	GO:0018108	peptidyl-tyrosine phosphorylation

0.85	GO:0070016	armadillo repeat domain binding
0.84	GO:0030331	estrogen receptor binding
0.84	GO:0051721	protein phosphatase 2A binding
0.72	GO:0032403	protein complex binding
0.45	GO:0005516	calmodulin binding
0.40	GO:0048306	calcium-dependent protein binding
0.35	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
0.34	GO:0004714	transmembrane receptor protein tyrosine kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.78	GO:0005923	bicellular tight junction
0.78	GO:0000159	protein phosphatase type 2A complex
0.47	GO:0043197	dendritic spine
0.44	GO:0014069	postsynaptic density
0.43	GO:0043025	neuronal cell body
0.42	GO:0045211	postsynaptic membrane
0.36	GO:0005737	cytoplasm
0.35	GO:0043234	protein complex
0.30	GO:0016021	integral component of membrane

0.35

GO:0016747

sp|O43818|U3IP2_HUMAN
U3 small nucleolar RNA-interacting protein 2
Search

RRP9

0.89	Ribosomal RNA processing 9, small subunit (SSU) processome component, homolog

0.69

GO:0006364

rRNA processing

0.83

GO:0030515

snoRNA binding

0.79	GO:0032040	small-subunit processome
0.79	GO:0031428	box C/D snoRNP complex

sp|O43819|SCO2_HUMAN
Protein SCO2 homolog, mitochondrial
Search

SCO2

0.45	Thymidine phosphorylase

0.77	GO:0008535	respiratory chain complex IV assembly
0.75	GO:0006878	cellular copper ion homeostasis
0.73	GO:0006825	copper ion transport
0.59	GO:0045454	cell redox homeostasis
0.53	GO:0014823	response to activity
0.51	GO:0001701	in utero embryonic development
0.50	GO:0003012	muscle system process
0.45	GO:0022904	respiratory electron transport chain
0.44	GO:2001171	positive regulation of ATP biosynthetic process
0.38	GO:0097034	mitochondrial respiratory chain complex IV biogenesis

0.67	GO:0005507	copper ion binding
0.38	GO:0015002	heme-copper terminal oxidase activity
0.38	GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
0.38	GO:0015078	hydrogen ion transmembrane transporter activity
0.38	GO:0009055	electron transfer activity
0.34	GO:0016530	metallochaperone activity
0.34	GO:0052689	carboxylic ester hydrolase activity
0.34	GO:0005515	protein binding
0.33	GO:0005549	odorant binding

0.59	GO:0031966	mitochondrial membrane
0.59	GO:0019866	organelle inner membrane
0.39	GO:0030016	myofibril
0.37	GO:0072492	host cell mitochondrial intermembrane space
0.35	GO:0005759	mitochondrial matrix
0.34	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

0.38	EC:1.9.3	GO:0016676
0.34	KEGG:R00630	GO:0052689

sp|O43820|HYAL3_HUMAN
Hyaluronidase-3
Search

HYAL3

0.72	Hyaluronidase

0.79	GO:0030214	hyaluronan catabolic process
0.66	GO:2000355	negative regulation of ovarian follicle development
0.66	GO:2000368	positive regulation of acrosomal vesicle exocytosis
0.65	GO:0001552	ovarian follicle atresia
0.64	GO:0007341	penetration of zona pellucida
0.63	GO:0071493	cellular response to UV-B
0.61	GO:0071347	cellular response to interleukin-1
0.60	GO:0005975	carbohydrate metabolic process
0.60	GO:0051216	cartilage development
0.60	GO:0071356	cellular response to tumor necrosis factor

0.85	GO:0004415	hyalurononglucosaminidase activity
0.64	GO:0033906	hyaluronoglucuronidase activity
0.44	GO:0001618	virus receptor activity
0.40	GO:0050501	hyaluronan synthase activity
0.38	GO:0008134	transcription factor binding
0.35	GO:0030294	receptor signaling protein tyrosine kinase inhibitor activity
0.34	GO:0008080	N-acetyltransferase activity
0.34	GO:0050431	transforming growth factor beta binding
0.34	GO:0001105	RNA polymerase II transcription coactivator activity
0.34	GO:0030971	receptor tyrosine kinase binding

0.62	GO:0097225	sperm midpiece
0.62	GO:0002080	acrosomal membrane
0.57	GO:0005769	early endosome
0.57	GO:0005764	lysosome
0.52	GO:0005783	endoplasmic reticulum
0.42	GO:0036117	hyaluranon cable
0.38	GO:0005615	extracellular space
0.36	GO:0005886	plasma membrane
0.34	GO:0005902	microvillus
0.34	GO:0030139	endocytic vesicle

0.85

EC:3.2.1.35

GO:0004415

sp|O43822|CU002_HUMAN
Protein C21orf2
Search

0.84	GO:0042769	DNA damage response, detection of DNA damage
0.77	GO:0007224	smoothened signaling pathway
0.74	GO:0060271	cilium assembly
0.66	GO:0007010	cytoskeleton organization
0.65	GO:0008360	regulation of cell shape
0.38	GO:0006002	fructose 6-phosphate metabolic process
0.38	GO:0061615	glycolytic process through fructose-6-phosphate
0.33	GO:0006468	protein phosphorylation

0.38	GO:0003872	6-phosphofructokinase activity
0.38	GO:0005515	protein binding
0.33	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.83	GO:0097733	photoreceptor cell cilium
0.82	GO:0036064	ciliary basal body
0.80	GO:0035869	ciliary transition zone
0.57	GO:0005739	mitochondrion
0.53	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.38

EC:2.7.1.11

GO:0003872

sp|O43823|AKAP8_HUMAN
A-kinase anchor protein 8
Search

AKAP8

0.95	A-kinase anchoring protein 8

0.68	GO:0033127	regulation of histone phosphorylation
0.68	GO:0071380	cellular response to prostaglandin E stimulus
0.68	GO:0031065	positive regulation of histone deacetylation
0.66	GO:0032720	negative regulation of tumor necrosis factor production
0.65	GO:0044839	cell cycle G2/M phase transition
0.64	GO:0071222	cellular response to lipopolysaccharide
0.63	GO:0007076	mitotic chromosome condensation
0.47	GO:0016310	phosphorylation
0.41	GO:0045087	innate immune response
0.38	GO:0015031	protein transport

0.68	GO:0034237	protein kinase A regulatory subunit binding
0.67	GO:0051059	NF-kappaB binding
0.65	GO:0042826	histone deacetylase binding
0.55	GO:0003677	DNA binding
0.54	GO:0017151	DEAD/H-box RNA helicase binding
0.48	GO:0016301	kinase activity
0.38	GO:0008270	zinc ion binding
0.36	GO:0003682	chromatin binding
0.35	GO:0003723	RNA binding
0.34	GO:0005521	lamin binding

0.69	GO:0001939	female pronucleus
0.66	GO:0016363	nuclear matrix
0.59	GO:0000793	condensed chromosome
0.55	GO:0005654	nucleoplasm
0.40	GO:0005730	nucleolus
0.40	GO:0005794	Golgi apparatus
0.37	GO:0005739	mitochondrion
0.36	GO:0000785	chromatin
0.35	GO:0044454	nuclear chromosome part
0.32	GO:0030529	intracellular ribonucleoprotein complex

sp|O43824|GTPB6_HUMAN
Putative GTP-binding protein 6
Search

GTPBP6

0.91	GTP-binding protein 6

0.32	GO:0032259	methylation
0.31	GO:0006807	nitrogen compound metabolic process

0.66	GO:0032550	purine ribonucleoside binding
0.66	GO:0019001	guanyl nucleotide binding
0.54	GO:0032553	ribonucleotide binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0043022	ribosome binding
0.34	GO:0046872	metal ion binding
0.32	GO:0008168	methyltransferase activity

0.36	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

0.32

GO:0008168

sp|O43825|B3GT2_HUMAN
Beta-1,3-galactosyltransferase 2
Search

B3GALT2

0.55	Hexosyltransferase

0.74	GO:0006486	protein glycosylation
0.59	GO:0006682	galactosylceramide biosynthetic process
0.49	GO:0009312	oligosaccharide biosynthetic process

0.80	GO:0008378	galactosyltransferase activity
0.50	GO:0008194	UDP-glycosyltransferase activity

0.74	GO:0000139	Golgi membrane
0.30	GO:0031224	intrinsic component of membrane

0.80

GO:0008378

sp|O43826|G6PT1_HUMAN
Glucose-6-phosphate exchanger SLC37A4
Search

SLC37A4

0.96	Glucose 6-phosphate transporter

0.59	GO:0015712	hexose phosphate transport
0.58	GO:0002318	myeloid progenitor cell differentiation
0.57	GO:0001780	neutrophil homeostasis
0.57	GO:0032682	negative regulation of chemokine production
0.57	GO:0035166	post-embryonic hemopoiesis
0.57	GO:0045730	respiratory burst
0.56	GO:0030593	neutrophil chemotaxis
0.55	GO:0042632	cholesterol homeostasis
0.55	GO:0055085	transmembrane transport
0.55	GO:0001816	cytokine production

0.56

GO:0022857

transmembrane transporter activity

0.40

GO:0030176

integral component of endoplasmic reticulum membrane

sp|O43827|ANGL7_HUMAN
Angiopoietin-related protein 7
Search

ANGPTL7

0.80	Fibrinogen C domain-containing protein 1

0.66	GO:0001525	angiogenesis
0.52	GO:0048014	Tie signaling pathway
0.49	GO:0043537	negative regulation of blood vessel endothelial cell migration
0.47	GO:0050928	negative regulation of positive chemotaxis
0.46	GO:0016525	negative regulation of angiogenesis
0.43	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
0.43	GO:0030168	platelet activation
0.42	GO:0043536	positive regulation of blood vessel endothelial cell migration
0.42	GO:0010812	negative regulation of cell-substrate adhesion
0.42	GO:0071456	cellular response to hypoxia

0.75	GO:0030971	receptor tyrosine kinase binding
0.44	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
0.42	GO:0030674	protein binding, bridging
0.34	GO:0004252	serine-type endopeptidase activity
0.34	GO:0005201	extracellular matrix structural constituent
0.33	GO:0046872	metal ion binding

0.49	GO:0005576	extracellular region
0.37	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.34

GO:0004252

sp|O43829|ZBT14_HUMAN
Zinc finger and BTB domain-containing protein 14
Search

ZBTB14

0.97	Zinc finger and BTB domain-containing protein 14

0.56	GO:0060976	coronary vasculature development
0.56	GO:0003170	heart valve development
0.55	GO:0003279	cardiac septum development
0.52	GO:0000122	negative regulation of transcription by RNA polymerase II
0.36	GO:0007016	cytoskeletal anchoring at plasma membrane
0.36	GO:0030866	cortical actin cytoskeleton organization
0.35	GO:0001558	regulation of cell growth
0.35	GO:0006351	transcription, DNA-templated
0.34	GO:0061411	positive regulation of transcription from RNA polymerase II promoter in response to cold
0.34	GO:0061403	positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress

0.55	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.53	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0005515	protein binding
0.35	GO:0046872	metal ion binding
0.34	GO:0005198	structural molecule activity
0.32	GO:0003924	GTPase activity
0.32	GO:0005525	GTP binding
0.32	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.32	GO:0004842	ubiquitin-protein transferase activity

0.57	GO:0016235	aggresome
0.50	GO:0005730	nucleolus
0.49	GO:0005654	nucleoplasm
0.49	GO:0005829	cytosol
0.35	GO:0005911	cell-cell junction
0.34	GO:0005856	cytoskeleton
0.33	GO:0005886	plasma membrane
0.32	GO:0031463	Cul3-RING ubiquitin ligase complex

0.32

GO:0004842

sp|O43830|ZNF73_HUMAN
Zinc finger protein 73
Search

0.60	Zinc finger protein 73

0.52	GO:1903506	regulation of nucleic acid-templated transcription
0.52	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.51	GO:0010468	regulation of gene expression
0.46	GO:0071294	cellular response to zinc ion
0.45	GO:1902679	negative regulation of RNA biosynthetic process
0.40	GO:0042254	ribosome biogenesis
0.38	GO:0006351	transcription, DNA-templated
0.38	GO:0014909	smooth muscle cell migration
0.37	GO:0048745	smooth muscle tissue development
0.37	GO:0060325	face morphogenesis

0.51	GO:0003676	nucleic acid binding
0.49	GO:0046872	metal ion binding
0.42	GO:0003700	DNA binding transcription factor activity
0.34	GO:0005515	protein binding

0.42	GO:0005634	nucleus
0.42	GO:0005813	centrosome
0.40	GO:0031974	membrane-enclosed lumen

sp|O43837|IDH3B_HUMAN
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Search

IDH3B

0.65	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

0.68	GO:0006099	tricarboxylic acid cycle
0.39	GO:0006102	isocitrate metabolic process
0.38	GO:0006734	NADH metabolic process
0.38	GO:0006103	2-oxoglutarate metabolic process
0.34	GO:0007033	vacuole organization
0.33	GO:0006886	intracellular protein transport
0.33	GO:0022900	electron transport chain

0.81	GO:0004449	isocitrate dehydrogenase (NAD+) activity
0.66	GO:0051287	NAD binding
0.63	GO:0000287	magnesium ion binding
0.33	GO:0009055	electron transfer activity

0.59	GO:0005739	mitochondrion
0.35	GO:0045242	isocitrate dehydrogenase complex (NAD+)
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0005634	nucleus
0.34	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

0.81

EC:1.1.1.41

GO:0004449

sp|O43847|NRDC_HUMAN
Nardilysin
Search

NRDC

0.88	Nardilysin convertase

0.60	GO:0006508	proteolysis
0.40	GO:0051044	positive regulation of membrane protein ectodomain proteolysis
0.38	GO:0052548	regulation of endopeptidase activity
0.36	GO:0007528	neuromuscular junction development
0.35	GO:0008283	cell proliferation
0.35	GO:0016477	cell migration
0.33	GO:0051604	protein maturation

0.69	GO:0004222	metalloendopeptidase activity
0.54	GO:0046872	metal ion binding
0.37	GO:0048408	epidermal growth factor binding

0.35	GO:0005739	mitochondrion
0.35	GO:0009986	cell surface
0.34	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.69

GO:0004222

sp|O43852|CALU_HUMAN
Calumenin
Search

CALU

0.94	Calumenin-B

0.35	GO:0048731	system development
0.35	GO:0048678	response to axon injury
0.35	GO:0043687	post-translational protein modification
0.35	GO:0031099	regeneration
0.34	GO:0014070	response to organic cyclic compound
0.34	GO:0120036	plasma membrane bounded cell projection organization
0.34	GO:0048468	cell development
0.34	GO:0001701	in utero embryonic development
0.34	GO:0043086	negative regulation of catalytic activity
0.33	GO:0033554	cellular response to stress

0.70	GO:0005509	calcium ion binding
0.35	GO:0005515	protein binding
0.34	GO:0004857	enzyme inhibitor activity

0.51	GO:0005783	endoplasmic reticulum
0.46	GO:0042470	melanosome
0.46	GO:0016528	sarcoplasm
0.42	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.42	GO:0005794	Golgi apparatus
0.41	GO:0031984	organelle subcompartment
0.41	GO:0043233	organelle lumen
0.41	GO:0005576	extracellular region
0.30	GO:0016021	integral component of membrane

sp|O43854|EDIL3_HUMAN
EGF-like repeat and discoidin I-like domain-containing protein 3
Search

EDIL3

0.94	EGF like repeats and discoidin domains 3

0.53	GO:0010811	positive regulation of cell-substrate adhesion
0.36	GO:0007155	cell adhesion
0.36	GO:0007275	multicellular organism development

0.82	GO:0005178	integrin binding
0.68	GO:0005509	calcium ion binding

0.50	GO:0031012	extracellular matrix
0.38	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

sp|O43861|ATP9B_HUMAN
Probable phospholipid-transporting ATPase IIB
Search

ATP9B

0.58	Phospholipid-transporting ATPase

0.80	GO:0045332	phospholipid translocation
0.47	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.43	GO:0006897	endocytosis

0.80	GO:0004012	phospholipid-translocating ATPase activity
0.64	GO:0000287	magnesium ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding

0.79	GO:0005802	trans-Golgi network
0.54	GO:0048471	perinuclear region of cytoplasm
0.45	GO:0005768	endosome
0.39	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.80

GO:0004012

sp|O43865|SAHH2_HUMAN
Adenosylhomocysteinase 2
Search

AHCYL1

0.55	Adenosylhomocysteinase

0.71	GO:0006730	one-carbon metabolic process
0.55	GO:0042045	epithelial fluid transport
0.55	GO:0010765	positive regulation of sodium ion transport
0.54	GO:0031440	regulation of mRNA 3'-end processing
0.54	GO:0038166	angiotensin-activated signaling pathway
0.54	GO:0006611	protein export from nucleus
0.53	GO:0044070	regulation of anion transport
0.53	GO:0051592	response to calcium ion
0.52	GO:0032412	regulation of ion transmembrane transporter activity
0.51	GO:0006378	mRNA polyadenylation

0.79	GO:0004013	adenosylhomocysteinase activity
0.48	GO:0042802	identical protein binding
0.34	GO:0005125	cytokine activity
0.34	GO:0008083	growth factor activity
0.34	GO:0004713	protein tyrosine kinase activity
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.30	GO:0003723	RNA binding

0.49	GO:0005829	cytosol
0.42	GO:0043231	intracellular membrane-bounded organelle
0.39	GO:0043005	neuron projection
0.34	GO:0016324	apical plasma membrane
0.33	GO:0012505	endomembrane system
0.33	GO:0005840	ribosome
0.30	GO:0044422	organelle part
0.30	GO:0016021	integral component of membrane
0.30	GO:0031982	vesicle
0.30	GO:0043230	extracellular organelle

0.79

EC:3.3.1.1

GO:0004013

sp|O43866|CD5L_HUMAN
CD5 antigen-like
Search

CD5L

0.97	Apoptosis inhibitor of macrophage

0.72	GO:0006898	receptor-mediated endocytosis
0.41	GO:0006954	inflammatory response
0.39	GO:0006915	apoptotic process
0.39	GO:0006968	cellular defense response
0.39	GO:0002376	immune system process
0.35	GO:0048584	positive regulation of response to stimulus
0.34	GO:0007155	cell adhesion
0.34	GO:0009617	response to bacterium
0.34	GO:0002684	positive regulation of immune system process
0.34	GO:0048522	positive regulation of cellular process

0.81	GO:0005044	scavenger receptor activity
0.35	GO:0070891	lipoteichoic acid binding
0.34	GO:0001530	lipopolysaccharide binding
0.34	GO:0005070	SH3/SH2 adaptor activity
0.34	GO:1904399	heparan sulfate binding
0.34	GO:0035375	zymogen binding
0.33	GO:0038187	pattern recognition receptor activity
0.33	GO:0048306	calcium-dependent protein binding
0.33	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
0.33	GO:0005507	copper ion binding

0.40	GO:0005576	extracellular region
0.38	GO:0009897	external side of plasma membrane
0.37	GO:0031982	vesicle
0.34	GO:0005737	cytoplasm
0.34	GO:0043235	receptor complex
0.34	GO:0098805	whole membrane
0.34	GO:0098588	bounding membrane of organelle
0.34	GO:0005903	brush border
0.33	GO:0001772	immunological synapse
0.33	GO:0044446	intracellular organelle part

0.33

EC:1.4.3

GO:0016641

sp|O43868|S28A2_HUMAN
Sodium/nucleoside cotransporter 2
Search

0.86	Sodium/nucleoside cotransporter

0.78	GO:1901642	nucleoside transmembrane transport
0.51	GO:0072530	purine-containing compound transmembrane transport
0.45	GO:0006863	purine nucleobase transport
0.43	GO:0072531	pyrimidine-containing compound transmembrane transport
0.43	GO:0015855	pyrimidine nucleobase transport
0.35	GO:0034394	protein localization to cell surface
0.35	GO:0001895	retina homeostasis
0.33	GO:0046483	heterocycle metabolic process
0.33	GO:1901360	organic cyclic compound metabolic process
0.33	GO:0006725	cellular aromatic compound metabolic process

0.86	GO:0005415	nucleoside:sodium symporter activity
0.47	GO:0015211	purine nucleoside transmembrane transporter activity
0.45	GO:0005345	purine nucleobase transmembrane transporter activity
0.43	GO:0005350	pyrimidine nucleobase transmembrane transporter activity

0.66	GO:0005887	integral component of plasma membrane
0.34	GO:0016324	apical plasma membrane

sp|O43869|OR2T1_HUMAN
Olfactory receptor 2T1
Search

0.45	Olfactory receptor

0.75	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.70	GO:0007186	G-protein coupled receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O43889|CREB3_HUMAN
Cyclic AMP-responsive element-binding protein 3
Search

CREB3

0.83	cAMP responsive element binding protein 3

0.84	GO:0030968	endoplasmic reticulum unfolded protein response
0.75	GO:0045944	positive regulation of transcription by RNA polymerase II
0.71	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.71	GO:0090026	positive regulation of monocyte chemotaxis
0.61	GO:0006366	transcription by RNA polymerase II
0.48	GO:0010714	positive regulation of collagen metabolic process
0.48	GO:0032965	regulation of collagen biosynthetic process
0.34	GO:2000326	negative regulation of ligand-dependent nuclear receptor transcription coactivator activity
0.34	GO:0019046	release from viral latency
0.34	GO:0090045	positive regulation of deacetylase activity

0.85	GO:0035497	cAMP response element binding
0.66	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.47	GO:0046332	SMAD binding
0.34	GO:0031726	CCR1 chemokine receptor binding
0.34	GO:0008140	cAMP response element binding protein binding
0.33	GO:0003682	chromatin binding
0.33	GO:0042803	protein homodimerization activity

0.60	GO:0005783	endoplasmic reticulum
0.57	GO:0005829	cytosol
0.54	GO:0005634	nucleus
0.33	GO:0043025	neuronal cell body
0.33	GO:0000139	Golgi membrane
0.33	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.33	GO:0043233	organelle lumen
0.30	GO:0016021	integral component of membrane

sp|O43895|XPP2_HUMAN
Xaa-Pro aminopeptidase 2
Search

XPNPEP2

0.87	X-prolyl aminopeptidase (Aminopeptidase P) 2, membrane-bound

0.60	GO:0006508	proteolysis
0.37	GO:0006501	C-terminal protein lipidation
0.35	GO:0034396	negative regulation of transcription from RNA polymerase II promoter in response to iron
0.33	GO:0006364	rRNA processing

0.74	GO:0070006	metalloaminopeptidase activity
0.52	GO:0046872	metal ion binding

0.56	GO:0070062	extracellular exosome
0.40	GO:0031225	anchored component of membrane
0.35	GO:0005886	plasma membrane
0.35	GO:0005829	cytosol
0.33	GO:0032040	small-subunit processome
0.30	GO:0016021	integral component of membrane

sp|O43896|KIF1C_HUMAN
Kinesin-like protein KIF1C
Search

KIF1C

0.92	Kinesin superfamily protein 1C

0.74	GO:0007018	microtubule-based movement
0.55	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.49	GO:0030705	cytoskeleton-dependent intracellular transport
0.39	GO:0007270	neuron-neuron synaptic transmission
0.38	GO:0051654	establishment of mitochondrion localization
0.38	GO:0007274	neuromuscular synaptic transmission
0.38	GO:0048917	posterior lateral line ganglion development
0.38	GO:0048918	posterior lateral line nerve development
0.37	GO:1990535	neuron projection maintenance
0.37	GO:0030225	macrophage differentiation

0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.42	GO:0016887	ATPase activity
0.34	GO:0003723	RNA binding
0.33	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity

0.50	GO:0005794	Golgi apparatus
0.49	GO:0015630	microtubule cytoskeleton
0.49	GO:0044430	cytoskeletal part
0.45	GO:0099512	supramolecular fiber
0.41	GO:0043234	protein complex
0.38	GO:1904115	axon cytoplasm
0.37	GO:0030659	cytoplasmic vesicle membrane
0.35	GO:0005739	mitochondrion
0.34	GO:0005783	endoplasmic reticulum
0.30	GO:0031224	intrinsic component of membrane

0.42

GO:0016887

sp|O43897|TLL1_HUMAN
Tolloid-like protein 1
Search

TLL1

0.62	Metalloendopeptidase

0.60	GO:0006508	proteolysis
0.51	GO:0048264	determination of ventral identity
0.50	GO:0033333	fin development
0.44	GO:0036342	post-anal tail morphogenesis
0.44	GO:0001885	endothelial cell development
0.44	GO:0030513	positive regulation of BMP signaling pathway
0.44	GO:0035162	embryonic hemopoiesis
0.43	GO:0001707	mesoderm formation
0.43	GO:0001503	ossification
0.43	GO:0035113	embryonic appendage morphogenesis

0.69	GO:0004222	metalloendopeptidase activity
0.69	GO:0005509	calcium ion binding
0.62	GO:0008270	zinc ion binding
0.35	GO:0005515	protein binding
0.35	GO:0004012	phospholipid-translocating ATPase activity
0.34	GO:0000287	magnesium ion binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0044877	macromolecular complex binding

0.30

GO:0016020

membrane

0.69

GO:0004222

sp|O43900|PRIC3_HUMAN
Prickle-like protein 3
Search

PRICKLE3

0.94	Prickle planar cell polarity protein 3

0.36	GO:0030030	cell projection organization
0.36	GO:0007275	multicellular organism development
0.34	GO:0060071	Wnt signaling pathway, planar cell polarity pathway

0.63	GO:0008270	zinc ion binding
0.34	GO:0005515	protein binding

0.51	GO:0005813	centrosome
0.44	GO:0005634	nucleus
0.37	GO:0005737	cytoplasm
0.36	GO:0098793	presynapse
0.35	GO:0012505	endomembrane system
0.35	GO:0097708	intracellular vesicle
0.34	GO:0005886	plasma membrane
0.32	GO:0031967	organelle envelope
0.32	GO:0031090	organelle membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O43903|GAS2_HUMAN
Growth arrest-specific protein 2
Search

GAS2

0.97	Growth arrest-specific protein 2

0.71	GO:0006915	apoptotic process
0.54	GO:0000226	microtubule cytoskeleton organization
0.53	GO:0030036	actin cytoskeleton organization
0.38	GO:0021923	cell proliferation in hindbrain ventricular zone
0.37	GO:0007050	cell cycle arrest
0.36	GO:0021591	ventricular system development
0.35	GO:0008360	regulation of cell shape

0.74	GO:0008017	microtubule binding
0.53	GO:0003779	actin binding

0.69	GO:0005856	cytoskeleton
0.36	GO:0099512	supramolecular fiber
0.34	GO:0044446	intracellular organelle part
0.34	GO:0005829	cytosol
0.33	GO:0043234	protein complex
0.30	GO:0016020	membrane

sp|O43908|NKG2F_HUMAN
NKG2-F type II integral membrane protein
Search

0.95	NK cell receptor C

0.40	GO:0006968	cellular defense response
0.35	GO:0002228	natural killer cell mediated immunity
0.35	GO:0007165	signal transduction
0.34	GO:0050776	regulation of immune response

0.64	GO:0030246	carbohydrate binding
0.45	GO:0023024	MHC class I protein complex binding
0.38	GO:1990405	protein antigen binding
0.36	GO:0099600	transmembrane receptor activity
0.35	GO:0038023	signaling receptor activity

0.41	GO:0043235	receptor complex
0.35	GO:0005887	integral component of plasma membrane

sp|O43909|EXTL3_HUMAN
Exostosin-like 3
Search

EXTL3

0.94	Exostosin like glycosyltransferase 3

0.74	GO:0006486	protein glycosylation
0.61	GO:0015012	heparan sulfate proteoglycan biosynthetic process
0.47	GO:0035118	embryonic pectoral fin morphogenesis
0.47	GO:0033564	anterior/posterior axon guidance
0.47	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway
0.46	GO:0031290	retinal ganglion cell axon guidance
0.46	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process
0.46	GO:0048538	thymus development
0.45	GO:0030516	regulation of axon extension
0.37	GO:0030307	positive regulation of cell growth

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.35	GO:0004872	receptor activity
0.33	GO:0046872	metal ion binding

0.50	GO:0005794	Golgi apparatus
0.50	GO:0005783	endoplasmic reticulum
0.35	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.35	GO:0031984	organelle subcompartment
0.30	GO:0031224	intrinsic component of membrane

0.65

GO:0016757

sp|O43913|ORC5_HUMAN
Origin recognition complex subunit 5
Search

ORC5

0.92	Origin recognition complex subunit 5

0.64	GO:0006260	DNA replication
0.35	GO:0000082	G1/S transition of mitotic cell cycle

0.47	GO:0003688	DNA replication origin binding
0.35	GO:0005515	protein binding
0.34	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding

0.79	GO:0000808	origin recognition complex
0.60	GO:0005634	nucleus
0.50	GO:0005829	cytosol
0.50	GO:0031974	membrane-enclosed lumen
0.38	GO:0000781	chromosome, telomeric region

sp|O43914|TYOBP_HUMAN
TYRO protein tyrosine kinase-binding protein
Search

TYROBP

0.97	TYRO protein tyrosine kinase-binding protein isoform 1

0.73	GO:0002281	macrophage activation involved in immune response
0.73	GO:2001204	regulation of osteoclast development
0.71	GO:0002283	neutrophil activation involved in immune response
0.65	GO:0007229	integrin-mediated signaling pathway
0.48	GO:0016310	phosphorylation
0.47	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
0.44	GO:0050776	regulation of immune response
0.39	GO:0006968	cellular defense response
0.39	GO:0002446	neutrophil mediated immunity
0.39	GO:0043299	leukocyte degranulation

0.61	GO:0005102	receptor binding
0.60	GO:0042802	identical protein binding
0.50	GO:0016301	kinase activity
0.47	GO:0043548	phosphatidylinositol 3-kinase binding
0.40	GO:0005057	signal transducer activity, downstream of receptor

0.63	GO:0009986	cell surface
0.39	GO:0030667	secretory granule membrane
0.36	GO:0005887	integral component of plasma membrane

sp|O43915|VEGFD_HUMAN
Vascular endothelial growth factor D
Search

VEGFD

0.97	Vascular endothelial growth factor D

0.75	GO:0010469	regulation of receptor activity
0.68	GO:0060754	positive regulation of mast cell chemotaxis
0.67	GO:0050930	induction of positive chemotaxis
0.64	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.63	GO:0050918	positive chemotaxis
0.61	GO:0071542	dopaminergic neuron differentiation
0.59	GO:0008284	positive regulation of cell proliferation
0.56	GO:0008283	cell proliferation
0.51	GO:0045766	positive regulation of angiogenesis
0.50	GO:0001936	regulation of endothelial cell proliferation

0.78	GO:0008083	growth factor activity
0.69	GO:0043185	vascular endothelial growth factor receptor 3 binding
0.64	GO:0042056	chemoattractant activity
0.54	GO:0042803	protein homodimerization activity
0.50	GO:0005161	platelet-derived growth factor receptor binding
0.38	GO:0043184	vascular endothelial growth factor receptor 2 binding

0.56	GO:0005615	extracellular space
0.38	GO:0031093	platelet alpha granule lumen
0.30	GO:0016020	membrane

sp|O43916|CHST1_HUMAN
Carbohydrate sulfotransferase 1
Search

CHST1

0.57	Carbohydrate sulfotransferase 1

0.61	GO:0042339	keratan sulfate metabolic process
0.58	GO:0005975	carbohydrate metabolic process
0.38	GO:0006954	inflammatory response
0.37	GO:0006024	glycosaminoglycan biosynthetic process
0.36	GO:0044272	sulfur compound biosynthetic process
0.36	GO:0006044	N-acetylglucosamine metabolic process
0.35	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process
0.35	GO:0030204	chondroitin sulfate metabolic process
0.34	GO:0043029	T cell homeostasis
0.33	GO:0006898	receptor-mediated endocytosis

0.78	GO:0008146	sulfotransferase activity
0.34	GO:0005044	scavenger receptor activity

0.70	GO:0000139	Golgi membrane
0.33	GO:0005802	trans-Golgi network
0.30	GO:0031224	intrinsic component of membrane

0.78

GO:0008146

sp|O43918|AIRE_HUMAN
Autoimmune regulator
Search

AIRE

0.95	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)

0.78	GO:0006959	humoral immune response
0.72	GO:0002509	central tolerance induction to self antigen
0.70	GO:0002458	peripheral T cell tolerance induction
0.69	GO:0097536	thymus epithelium morphogenesis
0.69	GO:2000410	regulation of thymocyte migration
0.68	GO:0006417	regulation of translation
0.68	GO:0032602	chemokine production
0.67	GO:0045060	negative thymic T cell selection
0.60	GO:0045944	positive regulation of transcription by RNA polymerase II
0.38	GO:0006366	transcription by RNA polymerase II

0.78	GO:0045182	translation regulator activity
0.63	GO:0042393	histone binding
0.61	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.61	GO:0003682	chromatin binding
0.56	GO:0042802	identical protein binding
0.53	GO:0046872	metal ion binding
0.52	GO:0003712	transcription cofactor activity
0.39	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.35	GO:0008080	N-acetyltransferase activity
0.33	GO:0010385	double-stranded methylated DNA binding

0.59	GO:0016604	nuclear body
0.47	GO:0005737	cytoplasm
0.33	GO:0055044	symplast
0.32	GO:0005911	cell-cell junction
0.32	GO:0005618	cell wall
0.30	GO:0031224	intrinsic component of membrane

0.35

GO:0008080

sp|O43920|NDUS5_HUMAN
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Search

NDUFS5

0.91	NADH dehydrogenase iron-sulfur protein 5

0.81	GO:0032981	mitochondrial respiratory chain complex I assembly
0.42	GO:0055114	oxidation-reduction process
0.42	GO:1902269	positive regulation of polyamine transmembrane transport
0.39	GO:0006596	polyamine biosynthetic process
0.39	GO:0043085	positive regulation of catalytic activity
0.36	GO:0006119	oxidative phosphorylation

0.42	GO:0042978	ornithine decarboxylase activator activity
0.41	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.37	GO:0001664	G-protein coupled receptor binding

0.78	GO:0005747	mitochondrial respiratory chain complex I
0.54	GO:0005758	mitochondrial intermembrane space

0.41

GO:0008137

sp|O43921|EFNA2_HUMAN
Ephrin-A2
Search

0.82	GO:0048013	ephrin receptor signaling pathway
0.55	GO:0030316	osteoclast differentiation
0.54	GO:0046849	bone remodeling
0.51	GO:0007411	axon guidance
0.46	GO:0071372	cellular response to follicle-stimulating hormone stimulus
0.46	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
0.46	GO:0048672	positive regulation of collateral sprouting
0.46	GO:0048668	collateral sprouting
0.46	GO:1904321	response to forskolin
0.46	GO:0090109	regulation of cell-substrate junction assembly

0.84	GO:0046875	ephrin receptor binding
0.47	GO:0005169	neurotrophin TRKB receptor binding
0.47	GO:0045499	chemorepellent activity
0.35	GO:0016301	kinase activity
0.35	GO:0005170	neurotrophin TRKC receptor binding
0.35	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
0.35	GO:0005168	neurotrophin TRKA receptor binding
0.33	GO:0003723	RNA binding
0.33	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.33	GO:0140096	catalytic activity, acting on a protein

0.46	GO:0031362	anchored component of external side of plasma membrane
0.44	GO:0005604	basement membrane
0.43	GO:0005912	adherens junction
0.40	GO:0043204	perikaryon
0.40	GO:0031594	neuromuscular junction
0.37	GO:0005901	caveola
0.30	GO:0016021	integral component of membrane

0.33

GO:0016773

sp|O43924|PDE6D_HUMAN
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Search

PDE6D

0.92	Phosphodiesterase 6D

0.78	GO:0007601	visual perception
0.75	GO:0034260	negative regulation of GTPase activity
0.43	GO:0001822	kidney development
0.42	GO:0001654	eye development

0.80	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.78	GO:0005095	GTPase inhibitor activity
0.71	GO:0017137	Rab GTPase binding

0.64	GO:0031410	cytoplasmic vesicle
0.61	GO:0005829	cytosol

0.80

EC:3.1.4.17

GO:0004114

sp|O43927|CXL13_HUMAN
C-X-C motif chemokine 13
Search

CXCL13

0.66	C-X-C motif chemokine

0.86	GO:0035768	endothelial cell chemotaxis to fibroblast growth factor
0.86	GO:2000545	negative regulation of endothelial cell chemotaxis to fibroblast growth factor
0.85	GO:0035754	B cell chemotaxis
0.84	GO:0010820	positive regulation of T cell chemotaxis
0.76	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.74	GO:0006955	immune response
0.73	GO:0010469	regulation of receptor activity
0.72	GO:0042742	defense response to bacterium
0.69	GO:0007267	cell-cell signaling
0.66	GO:0007166	cell surface receptor signaling pathway

0.86	GO:0031724	CXCR5 chemokine receptor binding
0.85	GO:0031735	CCR10 chemokine receptor binding
0.85	GO:0048248	CXCR3 chemokine receptor binding
0.84	GO:0008009	chemokine activity
0.81	GO:0017134	fibroblast growth factor binding
0.76	GO:0008201	heparin binding
0.69	GO:0046982	protein heterodimerization activity

0.67	GO:0005615	extracellular space
0.30	GO:0005623	cell

sp|O43929|ORC4_HUMAN
Origin recognition complex subunit 4
Search

ORC4

0.85	Origin recognition complex subunit 4

0.64	GO:0006260	DNA replication
0.35	GO:0000082	G1/S transition of mitotic cell cycle

0.58	GO:0003688	DNA replication origin binding
0.44	GO:1901265	nucleoside phosphate binding
0.43	GO:0036094	small molecule binding
0.38	GO:0097367	carbohydrate derivative binding
0.38	GO:0008144	drug binding
0.38	GO:0043168	anion binding
0.33	GO:0005515	protein binding

0.80	GO:0000808	origin recognition complex
0.60	GO:0005634	nucleus
0.57	GO:0000781	chromosome, telomeric region
0.52	GO:0031974	membrane-enclosed lumen
0.51	GO:0005829	cytosol

sp|O43930|PRKY_HUMAN
Putative serine/threonine-protein kinase PRKY
Search

PRKX

0.91	Protein kinase, X-linked

0.63	GO:0006468	protein phosphorylation
0.60	GO:2000696	regulation of epithelial cell differentiation involved in kidney development
0.59	GO:0001935	endothelial cell proliferation
0.58	GO:0043542	endothelial cell migration
0.58	GO:0060993	kidney morphogenesis
0.56	GO:0030099	myeloid cell differentiation
0.56	GO:0001525	angiogenesis
0.56	GO:0018209	peptidyl-serine modification
0.56	GO:0031589	cell-substrate adhesion
0.55	GO:0060562	epithelial tube morphogenesis

0.69	GO:0004674	protein serine/threonine kinase activity
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.47	GO:0060089	molecular transducer activity

0.46	GO:0005634	nucleus
0.39	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.69

GO:0004674

sp|O43933|PEX1_HUMAN
Peroxisome biogenesis factor 1
Search

PEX1

0.95	Peroxisomal biogenesis factor 1

0.82	GO:0072662	protein localization to peroxisome
0.82	GO:0043574	peroxisomal transport
0.73	GO:0072594	establishment of protein localization to organelle
0.71	GO:0006605	protein targeting
0.63	GO:0060152	microtubule-based peroxisome localization
0.53	GO:0017038	protein import
0.53	GO:0065002	intracellular protein transmembrane transport
0.32	GO:0009058	biosynthetic process

0.64	GO:0042623	ATPase activity, coupled
0.58	GO:0008022	protein C-terminus binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0032403	protein complex binding
0.35	GO:0005509	calcium ion binding
0.35	GO:0008289	lipid binding
0.33	GO:0019842	vitamin binding
0.33	GO:0050662	coenzyme binding

0.79	GO:0031903	microbody membrane
0.79	GO:0044439	peroxisomal part
0.50	GO:0005829	cytosol
0.38	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

sp|O43934|MFS11_HUMAN
UNC93-like protein MFSD11
Search

MFSD11

0.96	Major facilitator superfamily domain containing 11

0.30

GO:0044425

membrane part

sp|O60216|RAD21_HUMAN
Double-strand-break repair protein rad21 homolog
Search

RAD21

0.91	Double-strand-break repair protein rad21

0.61	GO:0045876	positive regulation of sister chromatid cohesion
0.60	GO:0071168	protein localization to chromatin
0.55	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle
0.55	GO:0045841	negative regulation of mitotic metaphase/anaphase transition
0.53	GO:0006357	regulation of transcription by RNA polymerase II
0.52	GO:0006366	transcription by RNA polymerase II
0.51	GO:0051173	positive regulation of nitrogen compound metabolic process
0.51	GO:0010604	positive regulation of macromolecule metabolic process
0.51	GO:0031325	positive regulation of cellular metabolic process
0.50	GO:0009891	positive regulation of biosynthetic process

0.54	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.51	GO:0032403	protein complex binding
0.47	GO:0003682	chromatin binding
0.38	GO:0043565	sequence-specific DNA binding

0.71	GO:0000228	nuclear chromosome
0.60	GO:0008278	cohesin complex
0.58	GO:0016363	nuclear matrix
0.51	GO:0005654	nucleoplasm
0.50	GO:0000785	chromatin
0.38	GO:0000775	chromosome, centromeric region
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O60218|AK1BA_HUMAN
Aldo-keto reductase family 1 member B10
Search

0.38	Aldo-keto reductase like

0.53	GO:0044598	doxorubicin metabolic process
0.53	GO:0044597	daunorubicin metabolic process
0.53	GO:0055114	oxidation-reduction process
0.48	GO:0071475	cellular hyperosmotic salinity response
0.45	GO:0016488	farnesol catabolic process
0.45	GO:0003091	renal water homeostasis
0.45	GO:0035809	regulation of urine volume
0.42	GO:0072001	renal system development
0.42	GO:0043066	negative regulation of apoptotic process
0.40	GO:0001523	retinoid metabolic process

0.54	GO:0016491	oxidoreductase activity
0.39	GO:0016918	retinal binding
0.38	GO:0070401	NADP+ binding
0.38	GO:0070402	NADPH binding
0.33	GO:0005515	protein binding

0.44	GO:0005829	cytosol
0.42	GO:0005654	nucleoplasm
0.40	GO:0070062	extracellular exosome
0.38	GO:0005739	mitochondrion
0.37	GO:0097454	Schwann cell microvillus
0.37	GO:0005764	lysosome
0.37	GO:0033010	paranodal junction
0.36	GO:0043220	Schmidt-Lanterman incisure
0.36	GO:0032838	plasma membrane bounded cell projection cytoplasm
0.35	GO:0048471	perinuclear region of cytoplasm

0.54

EC:1

GO:0016491

sp|O60220|TIM8A_HUMAN
Mitochondrial import inner membrane translocase subunit Tim8 A
Search

TIMM8A

0.97	Bruton tyrosine kinase

0.65	GO:0015031	protein transport
0.38	GO:0030001	metal ion transport
0.38	GO:0018108	peptidyl-tyrosine phosphorylation
0.37	GO:0098655	cation transmembrane transport
0.35	GO:0035556	intracellular signal transduction
0.35	GO:0007031	peroxisome organization
0.34	GO:0072655	establishment of protein localization to mitochondrion
0.34	GO:0006839	mitochondrial transport
0.34	GO:0007005	mitochondrion organization
0.34	GO:0007399	nervous system development

0.54	GO:0046872	metal ion binding
0.38	GO:0046873	metal ion transmembrane transporter activity
0.38	GO:0004713	protein tyrosine kinase activity
0.34	GO:0005515	protein binding
0.34	GO:0032559	adenyl ribonucleotide binding
0.34	GO:0008144	drug binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
0.32	GO:0003677	DNA binding

0.60	GO:0005739	mitochondrion
0.51	GO:0031970	organelle envelope lumen
0.37	GO:0031090	organelle membrane
0.35	GO:0044438	microbody part
0.34	GO:0005777	peroxisome
0.34	GO:0098805	whole membrane
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

0.38

EC:2.7.10

GO:0004713

sp|O60224|SSX4_HUMAN
Protein SSX4
Search

0.97	Synovial sarcoma, X breakpoint 5

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:1902679	negative regulation of RNA biosynthetic process
0.40	GO:0006351	transcription, DNA-templated

0.56	GO:0003714	transcription corepressor activity
0.50	GO:0003676	nucleic acid binding
0.38	GO:0005515	protein binding
0.38	GO:0003713	transcription coactivator activity

0.58	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|O60225|SSX5_HUMAN
Protein SSX5
Search

0.97	SSX family member 3

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.51	GO:0051253	negative regulation of RNA metabolic process
0.51	GO:0010558	negative regulation of macromolecule biosynthetic process
0.51	GO:0031327	negative regulation of cellular biosynthetic process
0.40	GO:0006351	transcription, DNA-templated

0.56	GO:0003714	transcription corepressor activity
0.50	GO:0003676	nucleic acid binding
0.39	GO:0005515	protein binding
0.38	GO:0003713	transcription coactivator activity

0.58	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|O60229|KALRN_HUMAN
Kalirin
Search

0.74	Kalirin RhoGEF kinase a

0.78	GO:0035023	regulation of Rho protein signal transduction
0.66	GO:0065009	regulation of molecular function
0.57	GO:0006468	protein phosphorylation
0.42	GO:0048731	system development
0.41	GO:0061368	behavioral response to formalin induced pain
0.41	GO:0060125	negative regulation of growth hormone secretion
0.41	GO:0048659	smooth muscle cell proliferation
0.41	GO:0060137	maternal process involved in parturition
0.41	GO:0014909	smooth muscle cell migration
0.41	GO:1900273	positive regulation of long-term synaptic potentiation

0.78	GO:0005089	Rho guanyl-nucleotide exchange factor activity
0.57	GO:0004672	protein kinase activity
0.50	GO:0032559	adenyl ribonucleotide binding
0.49	GO:0008144	drug binding
0.49	GO:0035639	purine ribonucleoside triphosphate binding
0.40	GO:0048365	Rac GTPase binding
0.36	GO:0005096	GTPase activator activity
0.33	GO:0046872	metal ion binding

0.40	GO:0005654	nucleoplasm
0.40	GO:0005829	cytosol
0.39	GO:0014069	postsynaptic density
0.37	GO:0070062	extracellular exosome
0.36	GO:0015629	actin cytoskeleton
0.30	GO:0016020	membrane

sp|O60231|DHX16_HUMAN
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
Search

DHX16

0.77	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

0.53	GO:0000398	mRNA splicing, via spliceosome
0.42	GO:0035987	endodermal cell differentiation
0.33	GO:0050911	detection of chemical stimulus involved in sensory perception of smell

0.67	GO:0004386	helicase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0003676	nucleic acid binding
0.45	GO:0008186	RNA-dependent ATPase activity
0.40	GO:0140098	catalytic activity, acting on RNA
0.37	GO:0019902	phosphatase binding
0.34	GO:0005549	odorant binding
0.33	GO:0004984	olfactory receptor activity

0.53	GO:0005681	spliceosomal complex
0.50	GO:0005654	nucleoplasm
0.36	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O60232|SSA27_HUMAN
Sjoegren syndrome/scleroderma autoantigen 1
Search

SSSCA1

0.97	Sjoegren syndrome/scleroderma autoantigen 1

0.40	GO:0000278	mitotic cell cycle
0.38	GO:0051301	cell division

0.72

GO:0042802

identical protein binding

0.30

GO:0016021

integral component of membrane

sp|O60234|GMFG_HUMAN
Glia maturation factor gamma
Search

GMFB

0.93	Glia maturation factor gamma

0.84	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation
0.68	GO:2000249	regulation of actin cytoskeleton reorganization
0.55	GO:0071846	actin filament debranching
0.50	GO:0007612	learning
0.49	GO:0007626	locomotory behavior
0.41	GO:0010469	regulation of receptor activity
0.36	GO:0042325	regulation of phosphorylation
0.36	GO:0051348	negative regulation of transferase activity
0.35	GO:0031400	negative regulation of protein modification process
0.35	GO:0010563	negative regulation of phosphorus metabolic process

0.85	GO:0071933	Arp2/3 complex binding
0.72	GO:0003779	actin binding
0.42	GO:0008083	growth factor activity
0.37	GO:0019207	kinase regulator activity
0.35	GO:0008047	enzyme activator activity
0.35	GO:0004857	enzyme inhibitor activity
0.33	GO:0004871	signal transducer activity

0.44	GO:0005622	intracellular
0.35	GO:0031983	vesicle lumen
0.34	GO:0012505	endomembrane system
0.33	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

sp|O60235|TM11D_HUMAN
Transmembrane protease serine 11D
Search

0.86	Transmembrane protease serine

0.61	GO:0006508	proteolysis
0.40	GO:0050890	cognition
0.38	GO:0006898	receptor-mediated endocytosis
0.37	GO:0007596	blood coagulation
0.37	GO:0007585	respiratory gaseous exchange
0.35	GO:0040008	regulation of growth
0.33	GO:0043010	camera-type eye development
0.33	GO:0006429	leucyl-tRNA aminoacylation
0.33	GO:0006887	exocytosis
0.33	GO:0006814	sodium ion transport

0.69	GO:0004252	serine-type endopeptidase activity
0.40	GO:0005044	scavenger receptor activity
0.37	GO:0005509	calcium ion binding
0.33	GO:0017080	sodium channel regulator activity
0.33	GO:0004823	leucine-tRNA ligase activity
0.33	GO:0005515	protein binding
0.32	GO:0002161	aminoacyl-tRNA editing activity
0.32	GO:0016758	transferase activity, transferring hexosyl groups
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.58	GO:0005576	extracellular region
0.57	GO:0005887	integral component of plasma membrane
0.38	GO:0043204	perikaryon
0.37	GO:0030425	dendrite
0.37	GO:0031982	vesicle
0.34	GO:0009986	cell surface
0.33	GO:0043195	terminal bouton
0.33	GO:0046658	anchored component of plasma membrane
0.32	GO:0005783	endoplasmic reticulum
0.32	GO:0005634	nucleus

0.69	EC:3.4.21	GO:0004252
0.33	KEGG:R03657	GO:0004823

sp|O60237|MYPT2_HUMAN
Protein phosphatase 1 regulatory subunit 12B
Search

PPP1R12B

0.86	Protein phosphatase 1, regulatory (Inhibitor) subunit 12B (Predicted)

0.67	GO:0050790	regulation of catalytic activity
0.59	GO:0007165	signal transduction
0.38	GO:0000278	mitotic cell cycle
0.38	GO:0044093	positive regulation of molecular function
0.38	GO:0035307	positive regulation of protein dephosphorylation
0.37	GO:0022402	cell cycle process
0.37	GO:0046822	regulation of nucleocytoplasmic transport
0.37	GO:0031023	microtubule organizing center organization
0.37	GO:0035690	cellular response to drug
0.36	GO:0006937	regulation of muscle contraction

0.77	GO:0019208	phosphatase regulator activity
0.75	GO:0019901	protein kinase binding
0.38	GO:0071889	14-3-3 protein binding
0.36	GO:0004857	enzyme inhibitor activity
0.35	GO:0008047	enzyme activator activity
0.33	GO:0004721	phosphoprotein phosphatase activity

0.43	GO:0031672	A band
0.43	GO:0030018	Z disc
0.37	GO:0072357	PTW/PP1 phosphatase complex
0.37	GO:0005829	cytosol
0.37	GO:0000776	kinetochore
0.37	GO:0005813	centrosome
0.35	GO:0015629	actin cytoskeleton
0.35	GO:0005654	nucleoplasm
0.34	GO:0005925	focal adhesion

0.33

GO:0004721

sp|O60238|BNI3L_HUMAN
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
Search

BNIP3L

0.65	BCL2 interacting protein 3 like

0.79	GO:0043065	positive regulation of apoptotic process
0.56	GO:0035694	mitochondrial protein catabolic process
0.55	GO:1903146	regulation of autophagy of mitochondrion
0.54	GO:1903214	regulation of protein targeting to mitochondrion
0.53	GO:0016239	positive regulation of macroautophagy
0.53	GO:0071456	cellular response to hypoxia
0.52	GO:0051607	defense response to virus
0.52	GO:0043069	negative regulation of programmed cell death
0.50	GO:0035794	positive regulation of mitochondrial membrane permeability
0.49	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process

0.55	GO:0005521	lamin binding
0.50	GO:0042803	protein homodimerization activity
0.49	GO:0046982	protein heterodimerization activity
0.34	GO:0008017	microtubule binding
0.34	GO:0019888	protein phosphatase regulator activity
0.33	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
0.32	GO:0003723	RNA binding

0.62	GO:0005740	mitochondrial envelope
0.52	GO:0031968	organelle outer membrane
0.51	GO:0016607	nuclear speck
0.51	GO:0005635	nuclear envelope
0.48	GO:0005783	endoplasmic reticulum
0.37	GO:0005829	cytosol
0.34	GO:0000159	protein phosphatase type 2A complex
0.33	GO:0005730	nucleolus
0.32	GO:0030529	intracellular ribonucleoprotein complex
0.30	GO:0016021	integral component of membrane

0.33

EC:3.5

GO:0016810

sp|O60239|3BP5_HUMAN
SH3 domain-binding protein 5
Search

SH3BP5

0.97	SH3-domain binding protein 5 (BTK-associated)

0.61	GO:0035556	intracellular signal transduction
0.57	GO:0006469	negative regulation of protein kinase activity
0.49	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
0.48	GO:0061097	regulation of protein tyrosine kinase activity
0.34	GO:0023014	signal transduction by protein phosphorylation
0.34	GO:0033554	cellular response to stress

0.58	GO:0004860	protein kinase inhibitor activity
0.46	GO:0017124	SH3 domain binding

0.55	GO:0016604	nuclear body
0.37	GO:0005737	cytoplasm

sp|O60240|PLIN1_HUMAN
Perilipin-1
Search

PLIN1

0.78

Perilipin

0.70	GO:0016042	lipid catabolic process
0.47	GO:0050995	negative regulation of lipid catabolic process
0.38	GO:0007018	microtubule-based movement

0.39	GO:0008289	lipid binding
0.39	GO:0005515	protein binding
0.38	GO:0003777	microtubule motor activity
0.35	GO:0030554	adenyl nucleotide binding
0.35	GO:0097367	carbohydrate derivative binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0008144	drug binding

0.79	GO:0005811	lipid droplet
0.66	GO:0005829	cytosol
0.44	GO:0005783	endoplasmic reticulum
0.37	GO:0071944	cell periphery
0.30	GO:0031224	intrinsic component of membrane

sp|O60241|AGRB2_HUMAN
Adhesion G protein-coupled receptor B2
Search

ADGRB2

0.96	Adhesion G protein-coupled receptor B2

0.84	GO:0016525	negative regulation of angiogenesis
0.71	GO:0007166	cell surface receptor signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.65	GO:0033173	calcineurin-NFAT signaling cascade
0.64	GO:0051965	positive regulation of synapse assembly
0.62	GO:0007422	peripheral nervous system development
0.37	GO:0061743	motor learning
0.36	GO:0099558	maintenance of synapse structure
0.36	GO:0016322	neuron remodeling
0.36	GO:0007520	myoblast fusion

0.72	GO:0004930	G-protein coupled receptor activity
0.37	GO:0005515	protein binding
0.35	GO:0005096	GTPase activator activity

0.59	GO:0005813	centrosome
0.45	GO:0005886	plasma membrane
0.36	GO:0043083	synaptic cleft
0.35	GO:0098794	postsynapse
0.30	GO:0031224	intrinsic component of membrane

sp|O60242|AGRB3_HUMAN
Adhesion G protein-coupled receptor B3
Search

ADGRB3

0.91	Adhesion G protein-coupled receptor B3

0.84	GO:0016525	negative regulation of angiogenesis
0.72	GO:0061743	motor learning
0.71	GO:0099558	maintenance of synapse structure
0.71	GO:0007166	cell surface receptor signaling pathway
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.69	GO:0007520	myoblast fusion
0.68	GO:0016322	neuron remodeling
0.67	GO:0051965	positive regulation of synapse assembly
0.67	GO:0048814	regulation of dendrite morphogenesis
0.60	GO:0043547	positive regulation of GTPase activity

0.72	GO:0004930	G-protein coupled receptor activity
0.60	GO:0005096	GTPase activator activity
0.38	GO:0005515	protein binding

0.69	GO:0043083	synaptic cleft
0.62	GO:0098794	postsynapse
0.47	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O60243|H6ST1_HUMAN
Heparan-sulfate 6-O-sulfotransferase 1
Search

HS6ST1

0.75	Heparan-sulfate 6-O-sulfotransferase

0.57	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification
0.50	GO:0048666	neuron development
0.48	GO:0048286	lung alveolus development
0.46	GO:0001525	angiogenesis
0.46	GO:0060716	labyrinthine layer blood vessel development
0.36	GO:0060173	limb development
0.34	GO:0006024	glycosaminoglycan biosynthetic process
0.33	GO:0006635	fatty acid beta-oxidation

0.78	GO:0008146	sulfotransferase activity
0.35	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding
0.34	GO:0070492	oligosaccharide binding
0.34	GO:0003997	acyl-CoA oxidase activity
0.33	GO:0071949	FAD binding

0.34	GO:0000139	Golgi membrane
0.34	GO:0005654	nucleoplasm
0.34	GO:0005887	integral component of plasma membrane
0.33	GO:0042579	microbody

0.78

GO:0008146

sp|O60244|MED14_HUMAN
Mediator of RNA polymerase II transcription subunit 14
Search

MED14

0.87	LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 14

0.68	GO:0006357	regulation of transcription by RNA polymerase II
0.61	GO:0019827	stem cell population maintenance
0.59	GO:0030521	androgen receptor signaling pathway
0.55	GO:0006367	transcription initiation from RNA polymerase II promoter
0.52	GO:0045893	positive regulation of transcription, DNA-templated
0.47	GO:0021591	ventricular system development
0.45	GO:0048514	blood vessel morphogenesis

0.76	GO:0001104	RNA polymerase II transcription cofactor activity
0.55	GO:0003713	transcription coactivator activity
0.48	GO:0004872	receptor activity
0.36	GO:0042809	vitamin D receptor binding

0.75	GO:0016592	mediator complex
0.49	GO:0070847	core mediator complex
0.30	GO:0031224	intrinsic component of membrane

sp|O60245|PCDH7_HUMAN
Protocadherin-7
Search

PCDH7B

0.95	LOW QUALITY PROTEIN: protocadherin-7

0.78	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.32	GO:0002576	platelet degranulation
0.32	GO:0007398	ectoderm development

0.70	GO:0005509	calcium ion binding
0.35	GO:0005515	protein binding

0.56	GO:0005886	plasma membrane
0.32	GO:0031092	platelet alpha granule membrane
0.30	GO:0044425	membrane part

sp|O60248|SOX15_HUMAN
Protein SOX-15
Search

SOX15

0.97	Transcription factor Sox-21-A

0.64	GO:0014718	positive regulation of satellite cell activation involved in skeletal muscle regeneration
0.64	GO:0048627	myoblast development
0.64	GO:0070318	positive regulation of G0 to G1 transition
0.63	GO:2000288	positive regulation of myoblast proliferation
0.62	GO:0043403	skeletal muscle tissue regeneration
0.60	GO:0045843	negative regulation of striated muscle tissue development
0.55	GO:0000122	negative regulation of transcription by RNA polymerase II
0.55	GO:0045944	positive regulation of transcription by RNA polymerase II
0.42	GO:0007275	multicellular organism development
0.41	GO:0007548	sex differentiation

0.56	GO:0003682	chromatin binding
0.55	GO:0003677	DNA binding
0.54	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
0.54	GO:0046982	protein heterodimerization activity
0.39	GO:0005516	calmodulin binding
0.33	GO:0003723	RNA binding
0.33	GO:0008080	N-acetyltransferase activity
0.32	GO:0046872	metal ion binding

0.61	GO:0005634	nucleus
0.54	GO:0005667	transcription factor complex
0.45	GO:0044446	intracellular organelle part
0.40	GO:0005737	cytoplasm
0.37	GO:0031974	membrane-enclosed lumen
0.30	GO:0016020	membrane

0.33

GO:0008080

sp|O60256|KPRB_HUMAN
Phosphoribosyl pyrophosphate synthase-associated protein 2
Search

PRPSAP2

0.96	Phosphoribosyl pyrophosphate synthetase associated protein 2

0.62	GO:0009165	nucleotide biosynthetic process
0.62	GO:0009116	nucleoside metabolic process
0.45	GO:0060348	bone development
0.34	GO:0043086	negative regulation of catalytic activity
0.32	GO:0043043	peptide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process
0.32	GO:0010467	gene expression
0.32	GO:0009059	macromolecule biosynthetic process

0.77	GO:0004749	ribose phosphate diphosphokinase activity
0.63	GO:0000287	magnesium ion binding
0.34	GO:0004857	enzyme inhibitor activity
0.34	GO:0005515	protein binding
0.33	GO:0003735	structural constituent of ribosome

0.37	GO:0002189	ribose phosphate diphosphokinase complex
0.34	GO:0043234	protein complex
0.32	GO:0005840	ribosome
0.30	GO:0016020	membrane

0.77	EC:2.7.6.1	GO:0004749
0.77	KEGG:R01049	GO:0004749

sp|O60258|FGF17_HUMAN
Fibroblast growth factor 17
Search

FGF17

0.62	Fibroblast growth factor

0.83	GO:0008543	fibroblast growth factor receptor signaling pathway
0.75	GO:0010469	regulation of receptor activity
0.54	GO:0008284	positive regulation of cell proliferation
0.50	GO:0030916	otic vesicle formation
0.50	GO:0030917	midbrain-hindbrain boundary development
0.49	GO:0030878	thyroid gland development
0.49	GO:0060037	pharyngeal system development
0.49	GO:0007498	mesoderm development
0.49	GO:0060128	corticotropin hormone secreting cell differentiation
0.48	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation

0.84	GO:0005104	fibroblast growth factor receptor binding
0.78	GO:0008083	growth factor activity
0.36	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
0.35	GO:0016303	1-phosphatidylinositol-3-kinase activity
0.35	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.35	GO:0004713	protein tyrosine kinase activity
0.34	GO:0042056	chemoattractant activity

0.66	GO:0005576	extracellular region
0.38	GO:0005764	lysosome
0.34	GO:0009897	external side of plasma membrane
0.30	GO:0031224	intrinsic component of membrane

0.36	EC:2.7.1.153	GO:0046934
0.36	KEGG:R04545	GO:0046934

sp|O60259|KLK8_HUMAN
Kallikrein-8
Search

0.89	LOW QUALITY PROTEIN: kallikrein-8

0.61	GO:0006508	proteolysis
0.52	GO:0031642	negative regulation of myelination
0.52	GO:0043616	keratinocyte proliferation
0.51	GO:0048681	negative regulation of axon regeneration
0.50	GO:0008219	cell death
0.49	GO:0007613	memory
0.49	GO:0050807	regulation of synapse organization
0.48	GO:0050808	synapse organization
0.48	GO:0009611	response to wounding
0.48	GO:0048812	neuron projection morphogenesis

0.69	GO:0004252	serine-type endopeptidase activity
0.35	GO:0005515	protein binding
0.35	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
0.34	GO:0004713	protein tyrosine kinase activity
0.33	GO:0005509	calcium ion binding
0.33	GO:0004674	protein serine/threonine kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.53	GO:0097180	serine protease inhibitor complex
0.50	GO:0005615	extracellular space
0.44	GO:0030141	secretory granule
0.36	GO:1903561	extracellular vesicle
0.33	GO:0005634	nucleus
0.33	GO:0005783	endoplasmic reticulum
0.33	GO:0043233	organelle lumen
0.33	GO:0005739	mitochondrion
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.32	GO:0044446	intracellular organelle part

0.69

GO:0004252

sp|O60260|PRKN2_HUMAN
E3 ubiquitin-protein ligase parkin
Search

PARK2

0.80	Parkinson disease (autosomal recessive, juvenile) 2, parkin

0.73	GO:0016567	protein ubiquitination
0.62	GO:1905365	regulation of intralumenal vesicle formation
0.62	GO:1904979	negative regulation of endosome organization
0.62	GO:1904049	negative regulation of spontaneous neurotransmitter secretion
0.61	GO:1902530	positive regulation of protein linear polyubiquitination
0.61	GO:1902283	negative regulation of primary amine oxidase activity
0.61	GO:1903381	regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
0.60	GO:1903542	negative regulation of exosomal secretion
0.60	GO:1903300	negative regulation of hexokinase activity
0.60	GO:0099074	mitochondrion to lysosome transport

0.73	GO:0004842	ubiquitin-protein transferase activity
0.62	GO:1990444	F-box domain binding
0.59	GO:0043274	phospholipase binding
0.58	GO:1990381	ubiquitin-specific protease binding
0.58	GO:0097602	cullin family protein binding
0.57	GO:0030544	Hsp70 protein binding
0.57	GO:0031624	ubiquitin conjugating enzyme binding
0.56	GO:0030165	PDZ domain binding
0.56	GO:0042826	histone deacetylase binding
0.55	GO:0008013	beta-catenin binding

0.67	GO:0005829	cytosol
0.66	GO:0000151	ubiquitin ligase complex
0.60	GO:0099073	mitochondrion-derived vesicle
0.60	GO:0005739	mitochondrion
0.57	GO:0016235	aggresome
0.54	GO:0005634	nucleus
0.53	GO:0048471	perinuclear region of cytoplasm
0.53	GO:0098793	presynapse
0.52	GO:0043005	neuron projection
0.50	GO:0005794	Golgi apparatus

0.52	EC:6	GO:0016874
0.73	KEGG:R03876	GO:0004842

sp|O60262|GBG7_HUMAN
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Search

GNG7

0.70	Guanine nucleotide-binding protein subunit gamma

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.40	GO:0048010	vascular endothelial growth factor receptor signaling pathway
0.40	GO:0002040	sprouting angiogenesis
0.37	GO:0007168	receptor guanylyl cyclase signaling pathway
0.36	GO:0071377	cellular response to glucagon stimulus
0.36	GO:0001662	behavioral fear response
0.36	GO:0045761	regulation of adenylate cyclase activity
0.36	GO:0007626	locomotory behavior
0.36	GO:0021987	cerebral cortex development
0.35	GO:0032496	response to lipopolysaccharide

0.64	GO:0004871	signal transducer activity
0.49	GO:0030165	PDZ domain binding
0.35	GO:0042301	phosphate ion binding
0.34	GO:0051015	actin filament binding
0.34	GO:0008017	microtubule binding
0.32	GO:0016787	hydrolase activity

0.81	GO:1905360	GTPase complex
0.80	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.66	GO:0098797	plasma membrane protein complex
0.37	GO:0070062	extracellular exosome
0.37	GO:0005829	cytosol
0.35	GO:0005884	actin filament
0.33	GO:0005874	microtubule

0.32

GO:0016787

sp|O60264|SMCA5_HUMAN
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
Search

SMARCA5

0.96	Imitation switch ISWI

0.81	GO:0043044	ATP-dependent chromatin remodeling
0.74	GO:0016569	covalent chromatin modification
0.53	GO:0016584	nucleosome positioning
0.53	GO:0000183	chromatin silencing at rDNA
0.52	GO:1990823	response to leukemia inhibitory factor
0.50	GO:0006334	nucleosome assembly
0.50	GO:0071345	cellular response to cytokine stimulus
0.48	GO:0045893	positive regulation of transcription, DNA-templated
0.46	GO:0006352	DNA-templated transcription, initiation
0.41	GO:0003231	cardiac ventricle development

0.83	GO:0031491	nucleosome binding
0.67	GO:0004386	helicase activity
0.61	GO:0016887	ATPase activity
0.55	GO:0030554	adenyl nucleotide binding
0.55	GO:0003677	DNA binding
0.54	GO:0032555	purine ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0042393	histone binding
0.34	GO:0008081	phosphoric diester hydrolase activity

0.84	GO:0016589	NURF complex
0.54	GO:0005677	chromatin silencing complex
0.54	GO:0031213	RSF complex
0.51	GO:0001650	fibrillar center
0.51	GO:0043596	nuclear replication fork
0.49	GO:0000793	condensed chromosome

0.61

GO:0016887

sp|O60266|ADCY3_HUMAN
Adenylate cyclase type 3
Search

ADCY3

0.94	Adenylate cyclase type 3

0.76	GO:0006171	cAMP biosynthetic process
0.64	GO:1904321	response to forskolin
0.64	GO:0008355	olfactory learning
0.62	GO:0007340	acrosome reaction
0.62	GO:0035556	intracellular signal transduction
0.61	GO:0030317	flagellated sperm motility
0.61	GO:1901655	cellular response to ketone
0.59	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
0.58	GO:0035690	cellular response to drug
0.57	GO:0071396	cellular response to lipid

0.76	GO:0004016	adenylate cyclase activity
0.52	GO:0032559	adenyl ribonucleotide binding
0.51	GO:0008144	drug binding
0.51	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0004383	guanylate cyclase activity
0.40	GO:0005516	calmodulin binding
0.38	GO:0004045	aminoacyl-tRNA hydrolase activity
0.35	GO:0046872	metal ion binding

0.56	GO:0005929	cilium
0.53	GO:0005886	plasma membrane
0.51	GO:0008074	guanylate cyclase complex, soluble
0.38	GO:0005794	Golgi apparatus
0.36	GO:0045121	membrane raft
0.34	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.76

EC:4.6.1.1

GO:0004016

sp|O60268|K0513_HUMAN
Uncharacterized protein KIAA0513
Search

0.37

GO:0006281

DNA repair

0.41	GO:0043240	Fanconi anaemia nuclear complex
0.41	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

sp|O60269|GRIN2_HUMAN
G protein-regulated inducer of neurite outgrowth 2
Search

GPRIN2

0.97	G protein-regulated inducer of neurite outgrowth 2

0.54	GO:0031175	neuron projection development
0.35	GO:0022900	electron transport chain

0.52	GO:0005515	protein binding
0.36	GO:0020037	heme binding
0.36	GO:0009055	electron transfer activity
0.34	GO:0046872	metal ion binding

0.46	GO:0030426	growth cone
0.43	GO:0005886	plasma membrane

sp|O60271|JIP4_HUMAN
C-Jun-amino-terminal kinase-interacting protein 4
Search

SPAG9

0.96	JNK-interacting leucine zipper protein long form

0.60	GO:0007257	activation of JUN kinase activity
0.59	GO:0090074	negative regulation of protein homodimerization activity
0.54	GO:0042147	retrograde transport, endosome to Golgi
0.54	GO:0030335	positive regulation of cell migration
0.54	GO:0051146	striated muscle cell differentiation
0.54	GO:0045666	positive regulation of neuron differentiation
0.52	GO:0051260	protein homooligomerization
0.37	GO:0006605	protein targeting
0.37	GO:0071806	protein transmembrane transport
0.36	GO:0051149	positive regulation of muscle cell differentiation

0.61	GO:0008432	JUN kinase binding
0.59	GO:0048273	mitogen-activated protein kinase p38 binding
0.58	GO:0019894	kinesin binding
0.53	GO:0016301	kinase activity
0.51	GO:0005078	MAP-kinase scaffold activity
0.50	GO:0030159	receptor signaling complex scaffold activity
0.37	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity

0.53	GO:0048471	perinuclear region of cytoplasm
0.52	GO:0005815	microtubule organizing center
0.49	GO:0005829	cytosol
0.39	GO:0070062	extracellular exosome
0.36	GO:0001669	acrosomal vesicle
0.30	GO:0016020	membrane

sp|O60279|SUSD5_HUMAN
Sushi domain-containing protein 5
Search

SUSD5

0.97	Sushi domain-containing protein 5

0.69	GO:0007155	cell adhesion
0.59	GO:0007219	Notch signaling pathway
0.32	GO:0016310	phosphorylation

0.82	GO:0005540	hyaluronic acid binding
0.32	GO:0016301	kinase activity

0.30

GO:0044425

membrane part

sp|O60281|ZN292_HUMAN
Zinc finger protein 292
Search

ZNF292

0.66	Zinc finger domain-containing protein (Fragment)

0.37	GO:0006366	transcription by RNA polymerase II
0.37	GO:0045944	positive regulation of transcription by RNA polymerase II

0.51	GO:0003676	nucleic acid binding
0.38	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.34	GO:0046872	metal ion binding

0.35

GO:0005634

nucleus

sp|O60282|KIF5C_HUMAN
Kinesin heavy chain isoform 5C
Search

KIF5C

0.85	Kinesin heavy chain isoform 5C

0.74	GO:0007018	microtubule-based movement
0.64	GO:0097120	receptor localization to synapse
0.63	GO:0030705	cytoskeleton-dependent intracellular transport
0.53	GO:0016192	vesicle-mediated transport
0.51	GO:0007411	axon guidance
0.44	GO:0008104	protein localization
0.41	GO:0051028	mRNA transport
0.40	GO:0046854	phosphatidylinositol phosphorylation
0.39	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
0.37	GO:0007268	chemical synaptic transmission

0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.63	GO:0019894	kinesin binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.44	GO:0042623	ATPase activity, coupled
0.41	GO:0016307	phosphatidylinositol phosphate kinase activity

0.67	GO:0035253	ciliary rootlet
0.65	GO:0032839	dendrite cytoplasm
0.60	GO:0043025	neuronal cell body
0.51	GO:0005871	kinesin complex
0.45	GO:0005874	microtubule
0.43	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.41

GO:0016307

sp|O60284|ST18_HUMAN
Suppression of tumorigenicity 18 protein
Search

0.58	Myelin transcription factor 1 like

0.71	GO:0048665	neuron fate specification
0.65	GO:0000122	negative regulation of transcription by RNA polymerase II
0.64	GO:0048666	neuron development
0.34	GO:0006351	transcription, DNA-templated

0.69	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.63	GO:0008270	zinc ion binding
0.34	GO:0003677	DNA binding

0.61	GO:0005634	nucleus
0.35	GO:0005694	chromosome

sp|O60285|NUAK1_HUMAN
NUAK family SNF1-like kinase 1
Search

NUAK1

0.97	NUAK family kinase 1

0.63	GO:0006468	protein phosphorylation
0.62	GO:0035507	regulation of myosin-light-chain-phosphatase activity
0.60	GO:2000772	regulation of cellular senescence
0.54	GO:0030155	regulation of cell adhesion
0.44	GO:0042149	cellular response to glucose starvation
0.43	GO:0035556	intracellular signal transduction
0.42	GO:0043066	negative regulation of apoptotic process
0.41	GO:0030036	actin cytoskeleton organization
0.36	GO:0007155	cell adhesion
0.36	GO:1901796	regulation of signal transduction by p53 class mediator

0.63	GO:0004672	protein kinase activity
0.59	GO:0002039	p53 binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:0000287	magnesium ion binding

0.59	GO:0001650	fibrillar center
0.52	GO:0015630	microtubule cytoskeleton
0.42	GO:0016607	nuclear speck
0.41	GO:0005737	cytoplasm

sp|O60287|NPA1P_HUMAN
Nucleolar pre-ribosomal-associated protein 1
Search

URB1

0.91	URB1 ribosome biogenesis 1 homolog (S. cerevisiae)

0.36

GO:0003723

RNA binding

0.83	GO:0001650	fibrillar center
0.30	GO:0031224	intrinsic component of membrane

sp|O60290|ZN862_HUMAN
Zinc finger protein 862
Search

0.10	Zinc finger protein 862

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.34	GO:0034654	nucleobase-containing compound biosynthetic process
0.34	GO:0009059	macromolecule biosynthetic process
0.34	GO:0090304	nucleic acid metabolic process
0.34	GO:0010467	gene expression
0.33	GO:0044260	cellular macromolecule metabolic process
0.33	GO:0042981	regulation of apoptotic process
0.32	GO:0043043	peptide biosynthetic process

0.50	GO:0003676	nucleic acid binding
0.48	GO:0046872	metal ion binding
0.48	GO:0046983	protein dimerization activity
0.39	GO:0003700	DNA binding transcription factor activity
0.34	GO:0003887	DNA-directed DNA polymerase activity
0.32	GO:1901265	nucleoside phosphate binding
0.32	GO:0003735	structural constituent of ribosome
0.32	GO:0036094	small molecule binding

0.44	GO:0005622	intracellular
0.38	GO:0031974	membrane-enclosed lumen
0.36	GO:0043227	membrane-bounded organelle
0.36	GO:0044422	organelle part
0.32	GO:1990904	ribonucleoprotein complex
0.32	GO:0043228	non-membrane-bounded organelle
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0003887

sp|O60291|MGRN1_HUMAN
E3 ubiquitin-protein ligase MGRN1
Search

MGRN1

0.91	Mahogunin ring finger 1

0.86	GO:0043951	negative regulation of cAMP-mediated signaling
0.85	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
0.85	GO:0008333	endosome to lysosome transport
0.83	GO:0006513	protein monoubiquitination
0.80	GO:0000209	protein polyubiquitination

0.74	GO:0061630	ubiquitin protein ligase activity
0.38	GO:0016874	ligase activity

0.79	GO:0005769	early endosome
0.61	GO:0005634	nucleus

0.38

GO:0016874

sp|O60292|SI1L3_HUMAN
Signal-induced proliferation-associated 1-like protein 3
Search

SIPA1L3

0.89	Signal-induced proliferation-associated 1 like 3

0.75	GO:0051056	regulation of small GTPase mediated signal transduction
0.74	GO:0043547	positive regulation of GTPase activity
0.58	GO:0003382	epithelial cell morphogenesis
0.58	GO:0090162	establishment of epithelial cell polarity
0.56	GO:0048731	system development
0.55	GO:0050773	regulation of dendrite development
0.55	GO:0007010	cytoskeleton organization
0.54	GO:0010769	regulation of cell morphogenesis involved in differentiation
0.53	GO:0120035	regulation of plasma membrane bounded cell projection organization
0.53	GO:0051960	regulation of nervous system development

0.75	GO:0005096	GTPase activator activity
0.39	GO:0046875	ephrin receptor binding

0.60	GO:0061689	tricellular tight junction
0.58	GO:0001725	stress fiber
0.55	GO:0045177	apical part of cell
0.38	GO:0098590	plasma membrane region
0.38	GO:0005615	extracellular space

sp|O60293|ZC3H1_HUMAN
Zinc finger C3H1 domain-containing protein
Search

ZFC3H1

0.97	Zinc finger C3H1 domain-containing protein isoform B

0.62	GO:0006396	RNA processing
0.39	GO:0046938	phytochelatin biosynthetic process
0.38	GO:0010038	response to metal ion

0.39	GO:0016756	glutathione gamma-glutamylcysteinyltransferase activity
0.35	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding
0.34	GO:0003723	RNA binding

0.58	GO:0000178	exosome (RNase complex)
0.48	GO:0005634	nucleus
0.35	GO:0005615	extracellular space
0.35	GO:0031974	membrane-enclosed lumen
0.34	GO:0043232	intracellular non-membrane-bounded organelle
0.34	GO:0044446	intracellular organelle part

0.39

EC:2.3.2.15

GO:0016756

sp|O60294|TYW4_HUMAN
tRNA wybutosine-synthesizing protein 4
Search

LCMT2

0.92	Leucine carboxyl methyltransferase 2

0.62	GO:0032259	methylation
0.47	GO:0031591	wybutosine biosynthetic process
0.36	GO:0044260	cellular macromolecule metabolic process
0.36	GO:1900458	negative regulation of brassinosteroid mediated signaling pathway

0.62	GO:0008168	methyltransferase activity
0.41	GO:0140101	catalytic activity, acting on a tRNA

0.42

GO:0005829

cytosol

0.62

GO:0008168

sp|O60296|TRAK2_HUMAN
Trafficking kinesin-binding protein 2
Search

TRAK2

0.97	Trafficking kinesin-binding protein 2

0.87	GO:0098939	dendritic transport of mitochondrion
0.86	GO:0098937	anterograde dendritic transport
0.57	GO:0008333	endosome to lysosome transport
0.53	GO:0098957	anterograde axonal transport of mitochondrion
0.48	GO:0050771	negative regulation of axonogenesis
0.48	GO:0048813	dendrite morphogenesis
0.46	GO:0006493	protein O-linked glycosylation
0.43	GO:0006605	protein targeting
0.43	GO:0006357	regulation of transcription by RNA polymerase II
0.38	GO:0006836	neurotransmitter transport

0.59	GO:0050811	GABA receptor binding
0.50	GO:0030911	TPR domain binding
0.48	GO:0019894	kinesin binding
0.43	GO:0019899	enzyme binding

0.85	GO:0032839	dendrite cytoplasm
0.55	GO:0033267	axon part
0.54	GO:0005769	early endosome
0.47	GO:0030426	growth cone
0.46	GO:0043025	neuronal cell body
0.45	GO:0005739	mitochondrion
0.41	GO:0005634	nucleus
0.39	GO:0005886	plasma membrane

sp|O60299|LZTS3_HUMAN
Leucine zipper putative tumor suppressor 3
Search

LZTS3

0.92	ProSAP-interacting protein 1

0.41	GO:0061001	regulation of dendritic spine morphogenesis
0.37	GO:0016055	Wnt signaling pathway
0.37	GO:0051255	spindle midzone assembly
0.37	GO:0030178	negative regulation of Wnt signaling pathway
0.37	GO:0051301	cell division
0.37	GO:0051013	microtubule severing
0.35	GO:0051168	nuclear export
0.35	GO:0051260	protein homooligomerization
0.34	GO:0060828	regulation of canonical Wnt signaling pathway
0.33	GO:1900181	negative regulation of protein localization to nucleus

0.36	GO:0043621	protein self-association
0.36	GO:0030165	PDZ domain binding
0.33	GO:0008013	beta-catenin binding
0.32	GO:0004672	protein kinase activity

0.83	GO:0014069	postsynaptic density
0.39	GO:0045211	postsynaptic membrane
0.39	GO:0005856	cytoskeleton
0.38	GO:0030054	cell junction
0.36	GO:0030496	midbody
0.36	GO:0043197	dendritic spine
0.36	GO:0099512	supramolecular fiber
0.35	GO:0005737	cytoplasm
0.34	GO:0044446	intracellular organelle part
0.32	GO:0031982	vesicle

sp|O60303|K0556_HUMAN
Protein KIAA0556
Search

0.67	GO:0005615	extracellular space
0.63	GO:0005856	cytoskeleton
0.63	GO:0042995	cell projection
0.46	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|O60304|ZN500_HUMAN
Zinc finger protein 500
Search

ZNF213

0.79	Zinc finger and SCAN domain-containing protein 29

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.53	GO:0006351	transcription, DNA-templated
0.46	GO:1902679	negative regulation of RNA biosynthetic process
0.33	GO:0006629	lipid metabolic process

0.61	GO:0003700	DNA binding transcription factor activity
0.51	GO:0046872	metal ion binding
0.50	GO:0003676	nucleic acid binding
0.33	GO:0005515	protein binding
0.30	GO:0003824	catalytic activity

0.60	GO:0005634	nucleus
0.40	GO:0005829	cytosol
0.40	GO:0031974	membrane-enclosed lumen
0.38	GO:0044446	intracellular organelle part

sp|O60306|AQR_HUMAN
Intron-binding protein aquarius
Search

AQR

0.90	Aquarius intron-binding spliceosomal factor

0.73	GO:0000398	mRNA splicing, via spliceosome
0.35	GO:0006283	transcription-coupled nucleotide-excision repair

0.47	GO:0003723	RNA binding
0.33	GO:0005515	protein binding

0.74	GO:0005681	spliceosomal complex
0.50	GO:1902494	catalytic complex
0.49	GO:0005654	nucleoplasm
0.30	GO:0016021	integral component of membrane

sp|O60307|MAST3_HUMAN
Microtubule-associated serine/threonine-protein kinase 3
Search

MAST3

0.89	Microtubule-associated serine/threonine-protein kinase 3

0.63	GO:0006468	protein phosphorylation
0.48	GO:0018209	peptidyl-serine modification
0.48	GO:0007010	cytoskeleton organization
0.44	GO:0045075	regulation of interleukin-12 biosynthetic process
0.44	GO:0035556	intracellular signal transduction
0.31	GO:0006508	proteolysis

0.70	GO:0004674	protein serine/threonine kinase activity
0.64	GO:0000287	magnesium ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding
0.31	GO:0004252	serine-type endopeptidase activity

0.37	GO:0005622	intracellular
0.30	GO:0016021	integral component of membrane

0.70

GO:0004674

sp|O60308|CE104_HUMAN
Centrosomal protein of 104 kDa
Search

CEP104

0.84	Centrosomal protein of

0.53	GO:0016596	thienylcyclohexylpiperidine binding
0.51	GO:0016595	glutamate binding
0.49	GO:0016594	glycine binding
0.41	GO:0004826	phenylalanine-tRNA ligase activity
0.39	GO:0005515	protein binding
0.37	GO:0003723	RNA binding

0.81	GO:0005814	centriole
0.46	GO:0000922	spindle pole
0.45	GO:0005929	cilium
0.30	GO:0044425	membrane part

0.41

EC:6.1.1.20

GO:0004826

sp|O60309|L37A3_HUMAN
Leucine-rich repeat-containing protein 37A3
Search

0.68	Leucine-rich repeat-containing protein 37A3

0.30

GO:0044425

membrane part

sp|O60312|AT10A_HUMAN
Probable phospholipid-transporting ATPase VA
Search

ATP10A

0.58	Phospholipid-transporting ATPase

0.80	GO:0045332	phospholipid translocation
0.34	GO:0008360	regulation of cell shape
0.34	GO:0034220	ion transmembrane transport
0.33	GO:0006812	cation transport

0.80	GO:0004012	phospholipid-translocating ATPase activity
0.64	GO:0000287	magnesium ion binding
0.55	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0005515	protein binding

0.53	GO:0005783	endoplasmic reticulum
0.41	GO:0005886	plasma membrane
0.40	GO:0005654	nucleoplasm
0.37	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.37	GO:0031984	organelle subcompartment
0.30	GO:0031224	intrinsic component of membrane

0.80

GO:0004012

sp|O60313|OPA1_HUMAN
Dynamin-like 120 kDa protein, mitochondrial
Search

OPA1

0.86	Dynamin-like protein, mitochondrial isoform D

0.78	GO:0006915	apoptotic process
0.75	GO:0007005	mitochondrion organization
0.62	GO:0097749	membrane tubulation
0.55	GO:0048284	organelle fusion
0.53	GO:0046039	GTP metabolic process
0.53	GO:0090201	negative regulation of release of cytochrome c from mitochondria
0.53	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
0.52	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission
0.52	GO:0090398	cellular senescence
0.50	GO:0007601	visual perception

0.68	GO:0003924	GTPase activity
0.66	GO:0005525	GTP binding
0.60	GO:1901612	cardiolipin binding
0.59	GO:0070300	phosphatidic acid binding
0.46	GO:0008017	microtubule binding
0.44	GO:0019900	kinase binding
0.36	GO:0000287	magnesium ion binding
0.34	GO:0003735	structural constituent of ribosome

0.61	GO:0005739	mitochondrion
0.54	GO:0031970	organelle envelope lumen
0.49	GO:0031968	organelle outer membrane
0.47	GO:0030425	dendrite
0.46	GO:0019866	organelle inner membrane
0.45	GO:0005654	nucleoplasm
0.45	GO:0031312	extrinsic component of organelle membrane
0.45	GO:0005829	cytosol
0.40	GO:1904115	axon cytoplasm
0.34	GO:0005840	ribosome

sp|O60315|ZEB2_HUMAN
Zinc finger E-box-binding homeobox 2
Search

ZEB2

0.92	Zinc finger E-box-binding homeobox 2

0.58	GO:1902748	positive regulation of lens fiber cell differentiation
0.57	GO:1903056	regulation of melanosome organization
0.57	GO:0061373	mammillary axonal complex development
0.56	GO:0045636	positive regulation of melanocyte differentiation
0.56	GO:0021540	corpus callosum morphogenesis
0.56	GO:0097324	melanocyte migration
0.56	GO:0021957	corticospinal tract morphogenesis
0.55	GO:0048668	collateral sprouting
0.54	GO:0021846	cell proliferation in forebrain
0.53	GO:0001755	neural crest cell migration

0.55	GO:0070412	R-SMAD binding
0.54	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
0.54	GO:0003677	DNA binding
0.53	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.48	GO:0046872	metal ion binding
0.35	GO:0019208	phosphatase regulator activity

0.50	GO:0005730	nucleolus
0.50	GO:0000790	nuclear chromatin
0.48	GO:0005829	cytosol

sp|O60318|GANP_HUMAN
Germinal-center associated nuclear protein
Search

MCM3AP

0.92	Germinal-center associated nuclear protein (Fragment)

0.45	GO:0051028	mRNA transport
0.44	GO:0002376	immune system process
0.43	GO:0006606	protein import into nucleus

0.51	GO:0003676	nucleic acid binding
0.38	GO:0016746	transferase activity, transferring acyl groups

0.50	GO:0031965	nuclear membrane
0.46	GO:0005643	nuclear pore
0.46	GO:0005829	cytosol
0.40	GO:0005654	nucleoplasm

0.38

GO:0016746

sp|O60320|F1891_HUMAN
Protein FAM189A1
Search

0.35

GO:0050699

WW domain binding

0.30

GO:0044425

membrane part

sp|O60330|PCDGC_HUMAN
Protocadherin gamma-A12
Search

0.93	Protocadherin gamma subfamily A 9

0.76	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
0.51	GO:0007267	cell-cell signaling
0.51	GO:0007399	nervous system development
0.38	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
0.37	GO:0007283	spermatogenesis
0.33	GO:0060989	lipid tube assembly involved in organelle fusion
0.33	GO:0008333	endosome to lysosome transport

0.68	GO:0005509	calcium ion binding
0.35	GO:0005515	protein binding
0.34	GO:0003723	RNA binding

0.54	GO:0005886	plasma membrane
0.37	GO:0005911	cell-cell junction
0.31	GO:0005622	intracellular
0.30	GO:0044425	membrane part

sp|O60331|PI51C_HUMAN
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Search

PIP5K1C

0.96	Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

0.74	GO:0046854	phosphatidylinositol phosphorylation
0.38	GO:0006909	phagocytosis
0.37	GO:0006661	phosphatidylinositol biosynthetic process
0.37	GO:0006887	exocytosis
0.37	GO:0098609	cell-cell adhesion
0.37	GO:0007016	cytoskeletal anchoring at plasma membrane
0.37	GO:0030168	platelet activation
0.36	GO:0006935	chemotaxis
0.36	GO:0007409	axonogenesis
0.35	GO:0048488	synaptic vesicle endocytosis

0.81	GO:0016307	phosphatidylinositol phosphate kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.39	GO:1990147	talin binding
0.37	GO:0052812	phosphatidylinositol-3,4-bisphosphate 5-kinase activity

0.49	GO:0010008	endosome membrane
0.46	GO:0005654	nucleoplasm
0.45	GO:0005829	cytosol
0.39	GO:0001931	uropod
0.39	GO:0001891	phagocytic cup
0.39	GO:0032587	ruffle membrane
0.38	GO:0005925	focal adhesion
0.35	GO:0098793	presynapse
0.30	GO:0031224	intrinsic component of membrane

0.81

GO:0016307

sp|O60333|KIF1B_HUMAN
Kinesin-like protein KIF1B
Search

KIF1B

0.96	Kinesin family member 1Bbeta isoform III

0.74	GO:0007018	microtubule-based movement
0.64	GO:0007270	neuron-neuron synaptic transmission
0.63	GO:0051654	establishment of mitochondrion localization
0.63	GO:0007274	neuromuscular synaptic transmission
0.61	GO:0030705	cytoskeleton-dependent intracellular transport
0.56	GO:0048917	posterior lateral line ganglion development
0.55	GO:0048918	posterior lateral line nerve development
0.54	GO:1990535	neuron projection maintenance
0.53	GO:0030225	macrophage differentiation
0.52	GO:0048675	axon extension

0.75	GO:0003777	microtubule motor activity
0.74	GO:0008017	microtubule binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.49	GO:0016887	ATPase activity

0.62	GO:1904115	axon cytoplasm
0.58	GO:0005875	microtubule associated complex
0.57	GO:0030659	cytoplasmic vesicle membrane
0.48	GO:0005739	mitochondrion

0.49

GO:0016887

sp|O60336|MABP1_HUMAN
Mitogen-activated protein kinase-binding protein 1
Search

MAPKBP1

0.87	Mitogen-activated protein kinase-binding protein 1

0.70	GO:2000483	negative regulation of interleukin-8 secretion
0.69	GO:1900425	negative regulation of defense response to bacterium
0.66	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
0.50	GO:0016310	phosphorylation
0.48	GO:0008380	RNA splicing
0.38	GO:0043507	positive regulation of JUN kinase activity
0.38	GO:0000186	activation of MAPKK activity
0.38	GO:0031098	stress-activated protein kinase signaling cascade
0.34	GO:0006464	cellular protein modification process

0.52	GO:0016301	kinase activity
0.42	GO:0003723	RNA binding
0.37	GO:0005515	protein binding

0.67	GO:0097431	mitotic spindle pole
0.53	GO:0071011	precatalytic spliceosome
0.53	GO:0005682	U5 snRNP
0.52	GO:0071013	catalytic step 2 spliceosome
0.42	GO:0005737	cytoplasm

sp|O60337|MARH6_HUMAN
E3 ubiquitin-protein ligase MARCH6
Search

MARCH6

0.89	Membrane associated ring-CH-type finger 6

0.65	GO:0070936	protein K48-linked ubiquitination
0.61	GO:0010498	proteasomal protein catabolic process
0.52	GO:0034976	response to endoplasmic reticulum stress
0.51	GO:0010243	response to organonitrogen compound
0.49	GO:0006511	ubiquitin-dependent protein catabolic process

0.67	GO:1990381	ubiquitin-specific protease binding
0.65	GO:0031624	ubiquitin conjugating enzyme binding
0.61	GO:0008270	zinc ion binding
0.59	GO:0004842	ubiquitin-protein transferase activity
0.50	GO:0061659	ubiquitin-like protein ligase activity

0.62

GO:0030176

integral component of endoplasmic reticulum membrane

0.59

GO:0004842

sp|O60341|KDM1A_HUMAN
Lysine-specific histone demethylase 1A
Search

KDM1A

0.92	Lysine-specific demethylase 1

0.85	GO:0034720	histone H3-K4 demethylation
0.56	GO:0032259	methylation
0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.53	GO:0033184	positive regulation of histone ubiquitination
0.53	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.53	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
0.53	GO:0033169	histone H3-K9 demethylation
0.52	GO:0071480	cellular response to gamma radiation

0.64	GO:0050660	flavin adenine dinucleotide binding
0.57	GO:0008168	methyltransferase activity
0.55	GO:0061752	telomeric repeat-containing RNA binding
0.54	GO:0043426	MRF binding
0.54	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)
0.54	GO:0003677	DNA binding
0.53	GO:0016491	oxidoreductase activity
0.53	GO:0032454	histone demethylase activity (H3-K9 specific)
0.53	GO:0050681	androgen receptor binding
0.51	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity

0.59	GO:0005634	nucleus
0.49	GO:0000781	chromosome, telomeric region
0.47	GO:1990391	DNA repair complex
0.46	GO:0000785	chromatin
0.44	GO:0070013	intracellular organelle lumen
0.41	GO:0043234	protein complex
0.30	GO:0016020	membrane

0.57

GO:0008168

sp|O60343|TBCD4_HUMAN
TBC1 domain family member 4
Search

TBC1D4

0.96	TBC1 domain family member 4 isoform A

0.75	GO:0043547	positive regulation of GTPase activity
0.56	GO:0032869	cellular response to insulin stimulus
0.50	GO:0031338	regulation of vesicle fusion
0.49	GO:0016192	vesicle-mediated transport
0.44	GO:0006886	intracellular protein transport
0.38	GO:0051051	negative regulation of transport
0.37	GO:0010639	negative regulation of organelle organization
0.34	GO:0061024	membrane organization

0.76	GO:0005096	GTPase activator activity
0.48	GO:0017137	Rab GTPase binding

0.49	GO:0005829	cytosol
0.44	GO:0012505	endomembrane system
0.38	GO:0070062	extracellular exosome
0.37	GO:0030659	cytoplasmic vesicle membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O60344|ECE2_HUMAN
Endothelin-converting enzyme 2
Search

ECE2

0.92	Endothelin-converting enzyme 2

0.84	GO:0016486	peptide hormone processing
0.47	GO:0070285	pigment cell development
0.45	GO:0030318	melanocyte differentiation
0.44	GO:0010002	cardioblast differentiation
0.42	GO:0007420	brain development
0.37	GO:0032259	methylation
0.35	GO:0042310	vasoconstriction
0.35	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.35	GO:0016567	protein ubiquitination
0.35	GO:0009792	embryo development ending in birth or egg hatching

0.69	GO:0004222	metalloendopeptidase activity
0.37	GO:0008168	methyltransferase activity
0.36	GO:0046983	protein dimerization activity
0.35	GO:0004842	ubiquitin-protein transferase activity
0.34	GO:0005201	extracellular matrix structural constituent
0.34	GO:0042802	identical protein binding
0.34	GO:0046872	metal ion binding

0.51	GO:0030659	cytoplasmic vesicle membrane
0.38	GO:0000139	Golgi membrane
0.36	GO:0030133	transport vesicle
0.36	GO:0098805	whole membrane
0.35	GO:0005802	trans-Golgi network
0.30	GO:0016021	integral component of membrane

0.69	EC:3.4.24	GO:0004222
0.35	KEGG:R03876	GO:0004842

sp|O60346|PHLP1_HUMAN
PH domain leucine-rich repeat-containing protein phosphatase 1
Search

PHLPP1

0.96	PH domain leucine-rich repeat-containing protein phosphatase 1

0.62	GO:0002911	regulation of lymphocyte anergy
0.62	GO:0002664	regulation of T cell tolerance induction
0.61	GO:1900744	regulation of p38MAPK cascade
0.60	GO:0009649	entrainment of circadian clock
0.59	GO:0051898	negative regulation of protein kinase B signaling
0.58	GO:0046328	regulation of JNK cascade
0.52	GO:0042981	regulation of apoptotic process
0.51	GO:0090036	regulation of protein kinase C signaling
0.45	GO:0006470	protein dephosphorylation
0.41	GO:0007165	signal transduction

0.47	GO:0004722	protein serine/threonine phosphatase activity
0.34	GO:0005515	protein binding
0.33	GO:0046872	metal ion binding

0.48	GO:0031965	nuclear membrane
0.39	GO:0005886	plasma membrane
0.37	GO:0005737	cytoplasm
0.35	GO:0048475	coated membrane
0.34	GO:0001917	photoreceptor inner segment
0.34	GO:0001750	photoreceptor outer segment
0.34	GO:0098796	membrane protein complex
0.33	GO:0098588	bounding membrane of organelle
0.32	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O60347|TBC12_HUMAN
TBC1 domain family member 12
Search

TBC1D12

0.77	TBC1 domain family member 12 isoform B

0.85	GO:2000785	regulation of autophagosome assembly
0.77	GO:0031338	regulation of vesicle fusion
0.77	GO:0090630	activation of GTPase activity
0.70	GO:0071955	recycling endosome to Golgi transport
0.63	GO:0006886	intracellular protein transport
0.58	GO:0010507	negative regulation of autophagy

0.73	GO:0017137	Rab GTPase binding
0.69	GO:0005096	GTPase activator activity
0.60	GO:0019901	protein kinase binding

0.83	GO:0005776	autophagosome
0.82	GO:0055037	recycling endosome
0.56	GO:0005794	Golgi apparatus
0.55	GO:0005654	nucleoplasm
0.54	GO:0005829	cytosol

sp|O60353|FZD6_HUMAN
Frizzled-6
Search

FZD6

0.96	Frizzled class receptor 6

0.77	GO:0016055	Wnt signaling pathway
0.67	GO:0007275	multicellular organism development
0.59	GO:0048105	establishment of body hair planar orientation
0.57	GO:0090175	regulation of establishment of planar polarity
0.57	GO:0061351	neural precursor cell proliferation
0.57	GO:0090090	negative regulation of canonical Wnt signaling pathway
0.56	GO:0043433	negative regulation of DNA binding transcription factor activity
0.56	GO:0030168	platelet activation
0.55	GO:0022405	hair cycle process
0.54	GO:0060322	head development

0.85	GO:0042813	Wnt-activated receptor activity
0.59	GO:0017147	Wnt-protein binding
0.54	GO:0031625	ubiquitin protein ligase binding
0.45	GO:0004930	G-protein coupled receptor activity
0.35	GO:0001540	amyloid-beta binding
0.34	GO:0030165	PDZ domain binding

0.58	GO:0016327	apicolateral plasma membrane
0.55	GO:0045177	apical part of cell
0.39	GO:0030659	cytoplasmic vesicle membrane
0.39	GO:0009986	cell surface
0.35	GO:0005887	integral component of plasma membrane
0.34	GO:0032433	filopodium tip
0.34	GO:0016328	lateral plasma membrane
0.34	GO:0048786	presynaptic active zone
0.34	GO:0043025	neuronal cell body
0.34	GO:0030425	dendrite

sp|O60356|NUPR1_HUMAN
Nuclear protein 1
Search

NUPR1

0.96	Nuclear protein 1, transcriptional regulator

0.84	GO:2000194	regulation of female gonad development
0.83	GO:0048147	negative regulation of fibroblast proliferation
0.82	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
0.80	GO:0002526	acute inflammatory response
0.80	GO:0035914	skeletal muscle cell differentiation
0.79	GO:0008584	male gonad development
0.74	GO:0008283	cell proliferation
0.73	GO:0043065	positive regulation of apoptotic process
0.72	GO:0045786	negative regulation of cell cycle
0.71	GO:0006473	protein acetylation

0.73	GO:0003682	chromatin binding
0.53	GO:0003677	DNA binding
0.38	GO:0005515	protein binding

0.67	GO:0032993	protein-DNA complex
0.65	GO:0005829	cytosol
0.60	GO:0005634	nucleus

sp|O60359|CCG3_HUMAN
Voltage-dependent calcium channel gamma-3 subunit
Search

CACNG3

0.85	Voltage-dependent calcium channel gamma subunit

0.77	GO:0034765	regulation of ion transmembrane transport
0.76	GO:0070588	calcium ion transmembrane transport
0.53	GO:1900449	regulation of glutamate receptor signaling pathway
0.53	GO:0099601	regulation of neurotransmitter receptor activity
0.52	GO:0006605	protein targeting
0.52	GO:0019226	transmission of nerve impulse
0.51	GO:0022898	regulation of transmembrane transporter activity
0.40	GO:0099628	neurotransmitter receptor diffusion trapping
0.40	GO:0098943	neurotransmitter receptor transport, postsynaptic endosome to lysosome
0.40	GO:0099590	neurotransmitter receptor internalization

0.79	GO:0005262	calcium channel activity
0.74	GO:0022832	voltage-gated channel activity
0.72	GO:0022839	ion gated channel activity
0.72	GO:0008381	mechanosensitive ion channel activity
0.50	GO:0016247	channel regulator activity
0.39	GO:0035255	ionotropic glutamate receptor binding

0.63	GO:0032281	AMPA glutamate receptor complex
0.57	GO:0036477	somatodendritic compartment
0.43	GO:0005891	voltage-gated calcium channel complex
0.40	GO:0098839	postsynaptic density membrane
0.38	GO:0005622	intracellular
0.37	GO:0043005	neuron projection
0.37	GO:0030054	cell junction
0.36	GO:0012506	vesicle membrane
0.36	GO:0098805	whole membrane
0.36	GO:0098588	bounding membrane of organelle

sp|O60361|NDK8_HUMAN
Putative nucleoside diphosphate kinase
Search

0.47	Nucleoside diphosphate kinase B

0.78	GO:0006228	UTP biosynthetic process
0.78	GO:0006183	GTP biosynthetic process
0.75	GO:0046036	CTP metabolic process
0.70	GO:0006165	nucleoside diphosphate phosphorylation
0.48	GO:0042981	regulation of apoptotic process
0.48	GO:0050679	positive regulation of epithelial cell proliferation
0.46	GO:0007595	lactation
0.45	GO:0043388	positive regulation of DNA binding
0.44	GO:2000026	regulation of multicellular organismal development
0.42	GO:0045597	positive regulation of cell differentiation

0.79	GO:0004550	nucleoside diphosphate kinase activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.45	GO:0043024	ribosomal small subunit binding
0.42	GO:0042802	identical protein binding
0.41	GO:0004536	deoxyribonuclease activity
0.41	GO:0019215	intermediate filament binding
0.40	GO:0046872	metal ion binding

0.49	GO:0001726	ruffle
0.46	GO:0043209	myelin sheath
0.44	GO:0031256	leading edge membrane
0.44	GO:0031253	cell projection membrane
0.43	GO:0030027	lamellipodium
0.42	GO:0005634	nucleus
0.42	GO:0005829	cytosol
0.41	GO:0005925	focal adhesion
0.40	GO:0005739	mitochondrion
0.39	GO:0070062	extracellular exosome

0.79

EC:2.7.4.6

GO:0004550

sp|O60381|HBP1_HUMAN
HMG box-containing protein 1
Search

HBP1

0.96	HMG-box transcription factor 1

0.39	GO:0016055	Wnt signaling pathway
0.37	GO:1903427	negative regulation of reactive oxygen species biosynthetic process
0.37	GO:0032369	negative regulation of lipid transport
0.35	GO:0006351	transcription, DNA-templated
0.35	GO:0010745	negative regulation of macrophage derived foam cell differentiation
0.35	GO:1903506	regulation of nucleic acid-templated transcription
0.35	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.35	GO:0010468	regulation of gene expression
0.35	GO:0007050	cell cycle arrest
0.35	GO:0043268	positive regulation of potassium ion transport

0.59	GO:0003723	RNA binding
0.54	GO:0003677	DNA binding
0.35	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.34	GO:0005515	protein binding
0.34	GO:0001067	regulatory region nucleic acid binding

0.61	GO:0005634	nucleus
0.48	GO:0031974	membrane-enclosed lumen
0.44	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|O60383|GDF9_HUMAN
Growth/differentiation factor 9
Search

GDF9

0.97	Growth and differentiation factor 9 variant FecG-Embrapa

0.75	GO:0010469	regulation of receptor activity
0.62	GO:2000870	regulation of progesterone secretion
0.59	GO:0001555	oocyte growth
0.55	GO:0030308	negative regulation of cell growth
0.54	GO:0008284	positive regulation of cell proliferation
0.47	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
0.47	GO:0060395	SMAD protein signal transduction
0.47	GO:0030509	BMP signaling pathway
0.45	GO:0043408	regulation of MAPK cascade
0.44	GO:0042981	regulation of apoptotic process

0.78	GO:0008083	growth factor activity
0.47	GO:0005125	cytokine activity
0.47	GO:0005160	transforming growth factor beta receptor binding

0.66	GO:0005576	extracellular region
0.39	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|O60384|ZN861_HUMAN
Putative zinc finger protein 861
Search

0.11	Putative zinc finger protein 861

0.51	GO:1903506	regulation of nucleic acid-templated transcription
0.51	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.51	GO:0010468	regulation of gene expression
0.41	GO:1902680	positive regulation of RNA biosynthetic process
0.40	GO:1902679	negative regulation of RNA biosynthetic process
0.37	GO:0006351	transcription, DNA-templated

0.51	GO:0003676	nucleic acid binding
0.50	GO:0046872	metal ion binding
0.39	GO:0003700	DNA binding transcription factor activity
0.35	GO:0005515	protein binding

0.42	GO:0005622	intracellular
0.37	GO:0043227	membrane-bounded organelle

sp|O60391|NMD3B_HUMAN
Glutamate receptor ionotropic, NMDA 3B
Search

GRIN3A

0.93	Glutamate ionotropic receptor NMDA type subunit 3B

0.78	GO:0060079	excitatory postsynaptic potential
0.76	GO:0035235	ionotropic glutamate receptor signaling pathway
0.60	GO:0034220	ion transmembrane transport
0.56	GO:0006816	calcium ion transport
0.53	GO:0051924	regulation of calcium ion transport
0.52	GO:0045471	response to ethanol
0.52	GO:0060134	prepulse inhibition
0.50	GO:0051205	protein insertion into membrane
0.49	GO:0016358	dendrite development
0.34	GO:0048511	rhythmic process

0.80	GO:0005234	extracellularly glutamate-gated ion channel activity
0.76	GO:0004970	ionotropic glutamate receptor activity
0.58	GO:0005262	calcium channel activity
0.55	GO:0016594	glycine binding
0.50	GO:0099094	ligand-gated cation channel activity
0.48	GO:0022843	voltage-gated cation channel activity
0.47	GO:0042802	identical protein binding
0.37	GO:0051721	protein phosphatase 2A binding

0.76	GO:0098794	postsynapse
0.65	GO:0017146	NMDA selective glutamate receptor complex
0.60	GO:0043025	neuronal cell body
0.55	GO:0097060	synaptic membrane
0.50	GO:0030054	cell junction
0.49	GO:0043005	neuron projection
0.36	GO:0032279	asymmetric synapse
0.33	GO:0043226	organelle

sp|O60393|NOBOX_HUMAN
Homeobox protein NOBOX
Search

NOBOX

0.90	NOBOX oogenesis homeobox

0.57	GO:0006357	regulation of transcription by RNA polymerase II
0.42	GO:0048609	multicellular organismal reproductive process
0.42	GO:0003006	developmental process involved in reproduction
0.41	GO:0022412	cellular process involved in reproduction in multicellular organism
0.41	GO:0007275	multicellular organism development
0.40	GO:0019953	sexual reproduction
0.40	GO:0048468	cell development
0.37	GO:0006351	transcription, DNA-templated
0.37	GO:0048511	rhythmic process
0.36	GO:0045893	positive regulation of transcription, DNA-templated

0.55	GO:0003677	DNA binding
0.37	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.36	GO:0001067	regulatory region nucleic acid binding
0.34	GO:0005201	extracellular matrix structural constituent
0.33	GO:0005509	calcium ion binding

0.61	GO:0005634	nucleus
0.33	GO:0005578	proteinaceous extracellular matrix
0.33	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|O60397|COX7S_HUMAN
Putative cytochrome c oxidase subunit 7A3, mitochondrial
Search

COX7A2

0.96	Cytochrome c oxidase subunit VIIa polypeptide 2 (Liver)

0.63	GO:1902600	hydrogen ion transmembrane transport
0.61	GO:0022900	electron transport chain

0.65	GO:0015002	heme-copper terminal oxidase activity
0.65	GO:0016675	oxidoreductase activity, acting on a heme group of donors
0.63	GO:0015078	hydrogen ion transmembrane transporter activity
0.62	GO:0009055	electron transfer activity

0.79	GO:0005746	mitochondrial respiratory chain
0.39	GO:0070062	extracellular exosome
0.34	GO:0045277	respiratory chain complex IV
0.30	GO:0016021	integral component of membrane

0.65

EC:1.9

GO:0016675

sp|O60403|O10H2_HUMAN
Olfactory receptor 10H2
Search

0.97	Olfactory receptor family 10 subfamily H member 2

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.59	GO:0007210	serotonin receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity
0.59	GO:0099589	serotonin receptor activity
0.54	GO:0030594	neurotransmitter receptor activity
0.32	GO:0003676	nucleic acid binding

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O60404|O10H3_HUMAN
Olfactory receptor 10H3
Search

0.31	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.59	GO:0007210	serotonin receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.71	GO:0004930	G-protein coupled receptor activity
0.59	GO:0099589	serotonin receptor activity
0.55	GO:0030594	neurotransmitter receptor activity
0.32	GO:0003676	nucleic acid binding

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O60412|OR7C2_HUMAN
Olfactory receptor 7C2
Search

0.45	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.34	GO:0007283	spermatogenesis
0.32	GO:2001141	regulation of RNA biosynthetic process
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression

0.76	GO:0004984	olfactory receptor activity
0.72	GO:0004930	G-protein coupled receptor activity

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O60422|ONEC3_HUMAN
One cut domain family member 3
Search

0.82	One cut homeobox 3

0.58	GO:0001889	liver development
0.58	GO:0006366	transcription by RNA polymerase II
0.58	GO:0045944	positive regulation of transcription by RNA polymerase II
0.57	GO:0031018	endocrine pancreas development
0.56	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
0.55	GO:0001952	regulation of cell-matrix adhesion
0.54	GO:0002064	epithelial cell development
0.54	GO:0030335	positive regulation of cell migration
0.54	GO:0045165	cell fate commitment
0.53	GO:0060271	cilium assembly

0.61	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.55	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.54	GO:0003677	DNA binding
0.53	GO:0001067	regulatory region nucleic acid binding

0.60	GO:0005634	nucleus
0.46	GO:0015629	actin cytoskeleton
0.45	GO:0005667	transcription factor complex
0.43	GO:0043233	organelle lumen
0.40	GO:0044446	intracellular organelle part
0.35	GO:0005829	cytosol

sp|O60423|AT8B3_HUMAN
Phospholipid-transporting ATPase IK
Search

0.59	Phospholipid-transporting ATPase IK

0.78	GO:0045332	phospholipid translocation
0.53	GO:0007339	binding of sperm to zona pellucida
0.50	GO:0032534	regulation of microvillus assembly
0.50	GO:0021650	vestibulocochlear nerve formation
0.49	GO:0007030	Golgi organization
0.49	GO:0015917	aminophospholipid transport
0.48	GO:0008206	bile acid metabolic process
0.47	GO:0060119	inner ear receptor cell development
0.46	GO:0007605	sensory perception of sound
0.44	GO:0006855	drug transmembrane transport

0.79	GO:0004012	phospholipid-translocating ATPase activity
0.63	GO:0000287	magnesium ion binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.50	GO:0015247	aminophospholipid transmembrane transporter activity
0.49	GO:1901612	cardiolipin binding
0.33	GO:0005515	protein binding
0.32	GO:0003676	nucleic acid binding

0.52	GO:0001669	acrosomal vesicle
0.48	GO:0005794	Golgi apparatus
0.47	GO:0032420	stereocilium
0.47	GO:0016324	apical plasma membrane
0.45	GO:0005783	endoplasmic reticulum
0.39	GO:0030667	secretory granule membrane
0.38	GO:0031526	brush border membrane
0.37	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.36	GO:0031984	organelle subcompartment
0.33	GO:0005887	integral component of plasma membrane

0.79

GO:0004012

sp|O60427|FADS1_HUMAN
Fatty acid desaturase 1
Search

FADS1

0.92	Delta-5 fatty acid desaturase

0.63	GO:0006629	lipid metabolic process
0.52	GO:0055114	oxidation-reduction process
0.40	GO:0072330	monocarboxylic acid biosynthetic process
0.40	GO:0035900	response to isolation stress
0.39	GO:0006690	icosanoid metabolic process
0.39	GO:0033189	response to vitamin A
0.39	GO:0009744	response to sucrose
0.38	GO:0032868	response to insulin
0.38	GO:0007568	aging
0.37	GO:0009267	cellular response to starvation

0.53	GO:0016491	oxidoreductase activity
0.38	GO:0020037	heme binding
0.36	GO:0046872	metal ion binding

0.40	GO:0005789	endoplasmic reticulum membrane
0.35	GO:0005739	mitochondrion
0.35	GO:0005634	nucleus
0.33	GO:0005887	integral component of plasma membrane

0.53

EC:1

GO:0016491

sp|O60431|OR1I1_HUMAN
Olfactory receptor 1I1
Search

0.43	Olfactory receptor

0.76	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.71	GO:0007186	G-protein coupled receptor signaling pathway

0.76	GO:0004984	olfactory receptor activity
0.72	GO:0004930	G-protein coupled receptor activity
0.49	GO:0005549	odorant binding

0.55	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O60437|PEPL_HUMAN
Periplakin
Search

PPL

0.95	Periplakin

0.61	GO:0009612	response to mechanical stimulus
0.38	GO:0070268	cornification
0.36	GO:0007010	cytoskeleton organization

0.60	GO:0045296	cadherin binding
0.36	GO:0005200	structural constituent of cytoskeleton

0.68	GO:0005856	cytoskeleton
0.39	GO:0070062	extracellular exosome
0.38	GO:0030057	desmosome
0.38	GO:0001533	cornified envelope
0.35	GO:0005829	cytosol
0.35	GO:0036338	viral membrane
0.35	GO:0005634	nucleus
0.34	GO:0005739	mitochondrion
0.32	GO:0019897	extrinsic component of plasma membrane

sp|O60443|DFNA5_HUMAN
Non-syndromic hearing impairment protein 5
Search

DFNA5

0.97	non-syndromic hearing impairment protein 5

0.85	GO:0070269	pyroptosis
0.81	GO:0070265	necrotic cell death
0.80	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
0.79	GO:0098586	cellular response to virus
0.78	GO:0060113	inner ear receptor cell differentiation
0.77	GO:0071356	cellular response to tumor necrosis factor
0.74	GO:0043410	positive regulation of MAPK cascade
0.73	GO:0008285	negative regulation of cell proliferation
0.42	GO:0007605	sensory perception of sound

0.85	GO:1901612	cardiolipin binding
0.79	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding

0.64	GO:0005829	cytosol
0.53	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O60447|EVI5_HUMAN
Ecotropic viral integration site 5 protein homolog
Search

EVI5

0.96	Ecotropic viral integration site 5

0.76	GO:0043547	positive regulation of GTPase activity
0.53	GO:0042147	retrograde transport, endosome to Golgi
0.49	GO:0031338	regulation of vesicle fusion
0.43	GO:0006886	intracellular protein transport
0.39	GO:1902017	regulation of cilium assembly
0.35	GO:0120033	negative regulation of plasma membrane bounded cell projection assembly
0.35	GO:1902116	negative regulation of organelle assembly
0.35	GO:0051301	cell division
0.35	GO:0007049	cell cycle
0.35	GO:0008283	cell proliferation

0.76	GO:0005096	GTPase activator activity
0.56	GO:0017137	Rab GTPase binding
0.31	GO:0003676	nucleic acid binding

0.49	GO:0005794	Golgi apparatus
0.48	GO:0005829	cytosol
0.36	GO:0005819	spindle
0.36	GO:0005815	microtubule organizing center
0.34	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|O60449|LY75_HUMAN
Lymphocyte antigen 75
Search

LY75

0.96	Lymphocyte antigen 75

0.42	GO:0007165	signal transduction
0.36	GO:0071222	cellular response to lipopolysaccharide
0.35	GO:0090238	positive regulation of arachidonic acid secretion
0.35	GO:0090403	oxidative stress-induced premature senescence
0.35	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
0.35	GO:0090399	replicative senescence
0.35	GO:0001816	cytokine production
0.34	GO:0006897	endocytosis
0.34	GO:0072593	reactive oxygen species metabolic process
0.33	GO:0055114	oxidation-reduction process

0.45	GO:0004888	transmembrane signaling receptor activity
0.35	GO:0043274	phospholipase binding
0.35	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.33	GO:0030246	carbohydrate binding

0.55	GO:0009897	external side of plasma membrane
0.44	GO:0005887	integral component of plasma membrane
0.34	GO:0043235	receptor complex
0.33	GO:0070062	extracellular exosome

0.35

GO:0016705

sp|O60462|NRP2_HUMAN
Neuropilin-2
Search

NRP2

0.91	Neuropilin

0.85	GO:0038084	vascular endothelial growth factor signaling pathway
0.83	GO:0071526	semaphorin-plexin signaling pathway
0.82	GO:0001525	angiogenesis
0.81	GO:0007411	axon guidance
0.53	GO:0001755	neural crest cell migration
0.49	GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway
0.48	GO:0001570	vasculogenesis
0.46	GO:0021612	facial nerve structural organization
0.45	GO:1904835	dorsal root ganglion morphogenesis
0.45	GO:0021649	vestibulocochlear nerve structural organization

0.85	GO:0005021	vascular endothelial growth factor-activated receptor activity
0.84	GO:0017154	semaphorin receptor activity
0.53	GO:0046872	metal ion binding
0.38	GO:0005515	protein binding
0.30	GO:0008201	heparin binding

0.42	GO:0030424	axon
0.30	GO:0032991	macromolecular complex
0.30	GO:0016020	membrane
0.30	GO:0005576	extracellular region
0.30	GO:0071944	cell periphery

sp|O60469|DSCAM_HUMAN
Down syndrome cell adhesion molecule
Search

DSCAM

0.85	Down syndrome cell adhesion molecule b

0.73	GO:0007399	nervous system development
0.71	GO:0007155	cell adhesion
0.58	GO:0060060	post-embryonic retina morphogenesis in camera-type eye
0.54	GO:0061387	regulation of extent of cell growth
0.54	GO:0010770	positive regulation of cell morphogenesis involved in differentiation
0.54	GO:0050921	positive regulation of chemotaxis
0.53	GO:0030307	positive regulation of cell growth
0.53	GO:0007162	negative regulation of cell adhesion
0.53	GO:0048639	positive regulation of developmental growth
0.53	GO:0016358	dendrite development

0.39

GO:0042803

protein homodimerization activity

0.64	GO:0005887	integral component of plasma membrane
0.53	GO:0030426	growth cone
0.52	GO:0030424	axon
0.40	GO:0045202	synapse
0.40	GO:0030054	cell junction
0.39	GO:0009986	cell surface
0.35	GO:0005576	extracellular region

sp|O60476|MA1A2_HUMAN
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
Search

MAN1A2

0.47	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

0.53	GO:0007585	respiratory gaseous exchange
0.53	GO:0048286	lung alveolus development
0.50	GO:0009100	glycoprotein metabolic process
0.36	GO:0043413	macromolecule glycosylation
0.34	GO:1901137	carbohydrate derivative biosynthetic process
0.34	GO:0036211	protein modification process
0.33	GO:0044267	cellular protein metabolic process
0.33	GO:1901566	organonitrogen compound biosynthetic process
0.33	GO:0009059	macromolecule biosynthetic process
0.33	GO:0044249	cellular biosynthetic process

0.82	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
0.70	GO:0005509	calcium ion binding

0.51	GO:0005794	Golgi apparatus
0.49	GO:0098588	bounding membrane of organelle
0.48	GO:0031984	organelle subcompartment
0.43	GO:0005783	endoplasmic reticulum
0.38	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
0.36	GO:0070062	extracellular exosome
0.36	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.82	EC:3.2.1.113	GO:0004571
0.82	KEGG:R05982 KEGG:R06722	GO:0004571

sp|O60477|BRNP1_HUMAN
BMP/retinoic acid-inducible neural-specific protein 1
Search

BRINP1

0.97	Bone morphogenetic protein/retinoic acid inducible neural-specific 1

0.82	GO:0045666	positive regulation of neuron differentiation
0.79	GO:0045930	negative regulation of mitotic cell cycle
0.60	GO:0071300	cellular response to retinoic acid
0.58	GO:0042711	maternal behavior
0.58	GO:0071625	vocalization behavior
0.58	GO:0007614	short-term memory
0.57	GO:0035640	exploration behavior
0.57	GO:0001662	behavioral fear response
0.57	GO:0035176	social behavior
0.54	GO:0050768	negative regulation of neurogenesis

0.33

GO:0005515

protein binding

0.48	GO:0043025	neuronal cell body
0.48	GO:0030425	dendrite
0.44	GO:0005783	endoplasmic reticulum

sp|O60478|G137B_HUMAN
Integral membrane protein GPR137B
Search

GPR137B

0.94	Integral membrane protein GPR137B

0.41	GO:0005765	lysosomal membrane
0.35	GO:0005887	integral component of plasma membrane

sp|O60479|DLX3_HUMAN
Homeobox protein DLX-3
Search

DLX3

0.97	Distal-less homeo box 3

0.61	GO:0071895	odontoblast differentiation
0.57	GO:0042475	odontogenesis of dentin-containing tooth
0.56	GO:0001890	placenta development
0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.54	GO:0001568	blood vessel development
0.52	GO:0006366	transcription by RNA polymerase II
0.51	GO:1902680	positive regulation of RNA biosynthetic process
0.35	GO:0048701	embryonic cranial skeleton morphogenesis

0.62	GO:0043565	sequence-specific DNA binding
0.55	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.53	GO:0003682	chromatin binding
0.33	GO:0005515	protein binding
0.33	GO:0003727	single-stranded RNA binding
0.33	GO:0001012	RNA polymerase II regulatory region DNA binding
0.33	GO:0003690	double-stranded DNA binding

0.61

GO:0005634

nucleus

sp|O60481|ZIC3_HUMAN
Zinc finger protein ZIC 3
Search

ZIC3

0.96	Zinc finger protein ZIC 3

0.58	GO:0007368	determination of left/right symmetry
0.56	GO:0003143	embryonic heart tube morphogenesis
0.56	GO:0009952	anterior/posterior pattern specification
0.56	GO:0007399	nervous system development
0.55	GO:0031016	pancreas development
0.55	GO:0001889	liver development
0.55	GO:0030324	lung development
0.55	GO:0048565	digestive tract development
0.54	GO:0006366	transcription by RNA polymerase II
0.54	GO:0045944	positive regulation of transcription by RNA polymerase II

0.57	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.56	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.37	GO:0031490	chromatin DNA binding
0.35	GO:0005515	protein binding
0.35	GO:0046872	metal ion binding

0.51	GO:0005654	nucleoplasm
0.40	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

sp|O60486|PLXC1_HUMAN
Plexin-C1
Search

0.83	GO:0071526	semaphorin-plexin signaling pathway
0.54	GO:0050772	positive regulation of axonogenesis
0.53	GO:0007162	negative regulation of cell adhesion
0.50	GO:0043087	regulation of GTPase activity
0.47	GO:0008360	regulation of cell shape
0.46	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching
0.45	GO:0043542	endothelial cell migration
0.45	GO:0001569	branching involved in blood vessel morphogenesis
0.44	GO:0060976	coronary vasculature development
0.44	GO:0035904	aorta development

0.84	GO:0017154	semaphorin receptor activity
0.42	GO:0019904	protein domain specific binding
0.36	GO:0005102	receptor binding

0.43	GO:0030027	lamellipodium
0.39	GO:0005887	integral component of plasma membrane
0.34	GO:0031256	leading edge membrane
0.34	GO:0031253	cell projection membrane

sp|O60487|MPZL2_HUMAN
Myelin protein zero-like protein 2
Search

MPZL2

0.97	Myelin protein zero like 2

0.77	GO:0098609	cell-cell adhesion
0.38	GO:0033077	T cell differentiation in thymus
0.35	GO:0009653	anatomical structure morphogenesis

0.38

GO:0042802

identical protein binding

0.34	GO:0005856	cytoskeleton
0.34	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

sp|O60488|ACSL4_HUMAN
Long-chain-fatty-acid--CoA ligase 4
Search

ACSL4

0.94	Long-chain fatty acyl-CoA synthetase 4

0.66	GO:0060136	embryonic process involved in female pregnancy
0.65	GO:0001676	long-chain fatty acid metabolic process
0.61	GO:0030182	neuron differentiation
0.50	GO:1900744	regulation of p38MAPK cascade
0.49	GO:0030513	positive regulation of BMP signaling pathway
0.48	GO:0051896	regulation of protein kinase B signaling
0.48	GO:0009953	dorsal/ventral pattern formation
0.45	GO:0034379	very-low-density lipoprotein particle assembly
0.45	GO:2001247	positive regulation of phosphatidylcholine biosynthetic process
0.45	GO:0044539	long-chain fatty acid import

0.74	GO:0047676	arachidonate-CoA ligase activity
0.68	GO:0031957	very long-chain fatty acid-CoA ligase activity
0.66	GO:0004467	long-chain fatty acid-CoA ligase activity
0.42	GO:0019901	protein kinase binding
0.41	GO:0019904	protein domain specific binding

0.67	GO:0005811	lipid droplet
0.66	GO:0044233	ER-mitochondrion membrane contact site
0.50	GO:0005739	mitochondrion
0.42	GO:0048471	perinuclear region of cytoplasm
0.40	GO:0005794	Golgi apparatus
0.40	GO:0005783	endoplasmic reticulum
0.30	GO:0031224	intrinsic component of membrane

0.74	EC:6.2.1.15	GO:0047676
0.74	KEGG:R01598	GO:0047676

sp|O60493|SNX3_HUMAN
Sorting nexin-3
Search

SNX3

0.75	Sorting nexin 3

0.59	GO:2000642	negative regulation of early endosome to late endosome transport
0.58	GO:0022615	protein to membrane docking
0.57	GO:0046597	negative regulation of viral entry into host cell
0.57	GO:0050765	negative regulation of phagocytosis
0.56	GO:0070676	intralumenal vesicle formation
0.55	GO:0010324	membrane invagination
0.55	GO:0042177	negative regulation of protein catabolic process
0.54	GO:0051224	negative regulation of protein transport
0.53	GO:0030111	regulation of Wnt signaling pathway
0.51	GO:0009617	response to bacterium

0.76	GO:0035091	phosphatidylinositol binding
0.54	GO:0019903	protein phosphatase binding

0.57	GO:0032009	early phagosome
0.55	GO:0031901	early endosome membrane
0.53	GO:0030904	retromer complex
0.52	GO:0030136	clathrin-coated vesicle
0.47	GO:0005829	cytosol
0.46	GO:0019898	extrinsic component of membrane
0.36	GO:0070062	extracellular exosome

sp|O60494|CUBN_HUMAN
Cubilin
Search

CUBN

0.51	Cubilin (intrinsic factor-cobalamin receptor)

0.51	GO:0042953	lipoprotein transport
0.48	GO:0006898	receptor-mediated endocytosis
0.41	GO:0006508	proteolysis
0.37	GO:0008203	cholesterol metabolic process
0.33	GO:0042366	cobalamin catabolic process
0.33	GO:0020028	hemoglobin import
0.33	GO:0070207	protein homotrimerization
0.33	GO:0007275	multicellular organism development
0.32	GO:0007219	Notch signaling pathway
0.32	GO:0007584	response to nutrient

0.68	GO:0005509	calcium ion binding
0.50	GO:0042803	protein homodimerization activity
0.44	GO:0004222	metalloendopeptidase activity
0.36	GO:0031419	cobalamin binding
0.33	GO:0038024	cargo receptor activity
0.33	GO:0030492	hemoglobin binding
0.33	GO:0005112	Notch binding
0.32	GO:0008168	methyltransferase activity
0.30	GO:0005215	transporter activity

0.55	GO:0005903	brush border
0.53	GO:0016324	apical plasma membrane
0.52	GO:0030139	endocytic vesicle
0.52	GO:0070062	extracellular exosome
0.52	GO:0005905	clathrin-coated pit
0.51	GO:0005768	endosome
0.48	GO:0005794	Golgi apparatus
0.48	GO:0005783	endoplasmic reticulum
0.37	GO:0031253	cell projection membrane
0.37	GO:0005765	lysosomal membrane

0.44

GO:0004222

sp|O60496|DOK2_HUMAN
Docking protein 2
Search

DOK2

0.95	Downstream of tyrosine kinase 2

0.79	GO:0007265	Ras protein signal transduction
0.75	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.41	GO:0007411	axon guidance
0.40	GO:0050900	leukocyte migration
0.39	GO:0016310	phosphorylation
0.36	GO:0036211	protein modification process
0.35	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
0.35	GO:0044267	cellular protein metabolic process
0.32	GO:0006457	protein folding

0.83	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
0.76	GO:0005057	signal transducer activity, downstream of receptor
0.39	GO:0016301	kinase activity
0.32	GO:0003755	peptidyl-prolyl cis-trans isomerase activity

0.49	GO:0005829	cytosol
0.44	GO:0005634	nucleus
0.35	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0016020	membrane

0.32

GO:0003755

sp|O60499|STX10_HUMAN
Syntaxin-10
Search

STX6

0.89	Syntaxin 6

0.75	GO:0048193	Golgi vesicle transport
0.66	GO:0006886	intracellular protein transport
0.66	GO:0061025	membrane fusion
0.58	GO:0042147	retrograde transport, endosome to Golgi
0.55	GO:0048284	organelle fusion
0.55	GO:0090161	Golgi ribbon formation
0.55	GO:0016050	vesicle organization
0.54	GO:0032880	regulation of protein localization
0.52	GO:0032456	endocytic recycling
0.49	GO:0048278	vesicle docking

0.78	GO:0005484	SNAP receptor activity
0.60	GO:0000149	SNARE binding

0.57	GO:0005802	trans-Golgi network
0.57	GO:0048471	perinuclear region of cytoplasm
0.56	GO:0031201	SNARE complex
0.53	GO:0031982	vesicle
0.51	GO:0005829	cytosol
0.48	GO:0000139	Golgi membrane
0.46	GO:0005654	nucleoplasm
0.37	GO:0043195	terminal bouton
0.36	GO:0031301	integral component of organelle membrane
0.36	GO:0098805	whole membrane

sp|O60500|NPHN_HUMAN
Nephrin
Search

NPHS1

0.90	Nephrosis 1, congenital, Finnish type (nephrin)

0.69	GO:0032836	glomerular basement membrane development
0.69	GO:0072015	glomerular visceral epithelial cell development
0.68	GO:0035418	protein localization to synapse
0.67	GO:0044062	regulation of excretion
0.67	GO:0014902	myotube differentiation
0.66	GO:0007519	skeletal muscle tissue development
0.65	GO:0000768	syncytium formation by plasma membrane fusion
0.65	GO:0007254	JNK cascade
0.61	GO:0030838	positive regulation of actin filament polymerization
0.56	GO:0007155	cell adhesion

0.65	GO:0017022	myosin binding
0.39	GO:0051393	alpha-actinin binding
0.38	GO:0030507	spectrin binding
0.37	GO:0019904	protein domain specific binding
0.36	GO:0004657	proline dehydrogenase activity
0.33	GO:0005216	ion channel activity
0.31	GO:0003755	peptidyl-prolyl cis-trans isomerase activity

0.54	GO:0042995	cell projection
0.52	GO:0036057	slit diaphragm
0.47	GO:0005886	plasma membrane
0.41	GO:0070062	extracellular exosome
0.39	GO:0005622	intracellular
0.37	GO:0098857	membrane microdomain
0.35	GO:0043234	protein complex
0.34	GO:0005913	cell-cell adherens junction
0.34	GO:0045177	apical part of cell
0.33	GO:0012505	endomembrane system

0.36

EC:1.5.99.8

GO:0004657

sp|O60502|OGA_HUMAN
Protein O-GlcNAcase
Search

MGEA5

0.96	Meningioma expressed antigen 5

0.80	GO:0006517	protein deglycosylation
0.72	GO:0006044	N-acetylglucosamine metabolic process

0.87

GO:0016231

beta-N-acetylglucosaminidase activity

0.64	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O60503|ADCY9_HUMAN
Adenylate cyclase type 9
Search

ADCY9

0.91	Adenylate cyclase type 9

0.75	GO:0009190	cyclic nucleotide biosynthetic process
0.63	GO:0035556	intracellular signal transduction
0.59	GO:0071875	adrenergic receptor signaling pathway
0.57	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
0.56	GO:0046058	cAMP metabolic process
0.50	GO:0009152	purine ribonucleotide biosynthetic process
0.47	GO:0046068	cGMP metabolic process
0.37	GO:0034199	activation of protein kinase A activity
0.36	GO:0071377	cellular response to glucagon stimulus
0.36	GO:0003091	renal water homeostasis

0.75	GO:0016849	phosphorus-oxygen lyase activity
0.57	GO:0009975	cyclase activity
0.52	GO:1901265	nucleoside phosphate binding
0.51	GO:0036094	small molecule binding
0.35	GO:0097367	carbohydrate derivative binding
0.35	GO:0008144	drug binding
0.35	GO:0046872	metal ion binding
0.34	GO:0043168	anion binding

0.49	GO:0005887	integral component of plasma membrane
0.49	GO:0008074	guanylate cyclase complex, soluble
0.39	GO:0030425	dendrite
0.39	GO:0030424	axon

0.75

EC:4.6

GO:0016849

sp|O60504|VINEX_HUMAN
Vinexin
Search

SORBS3

0.89	Sorbin and SH3 domain containing 3

0.75	GO:0007015	actin filament organization
0.73	GO:0051496	positive regulation of stress fiber assembly
0.70	GO:0007155	cell adhesion
0.67	GO:0043410	positive regulation of MAPK cascade
0.66	GO:0000122	negative regulation of transcription by RNA polymerase II

0.75	GO:0017166	vinculin binding
0.62	GO:0008134	transcription factor binding
0.34	GO:0005158	insulin receptor binding
0.33	GO:0030246	carbohydrate binding

0.69	GO:0005925	focal adhesion
0.54	GO:0005634	nucleus
0.44	GO:0005737	cytoplasm
0.35	GO:0005899	insulin receptor complex
0.34	GO:0005813	centrosome

sp|O60506|HNRPQ_HUMAN
Heterogeneous nuclear ribonucleoprotein Q
Search

SYNCRIP

0.80	Synaptotagmin-binding cytoplasmic RNA-interacting protein (Fragment)

0.75	GO:0070934	CRD-mediated mRNA stabilization
0.70	GO:0071346	cellular response to interferon-gamma
0.63	GO:0017148	negative regulation of translation

0.65	GO:0008143	poly(A) binding
0.35	GO:0005515	protein binding

0.75	GO:0097452	GAIT complex
0.74	GO:0070937	CRD-mediated mRNA stability complex
0.69	GO:0071204	histone pre-mRNA 3'end processing complex
0.67	GO:0071013	catalytic step 2 spliceosome

sp|O60507|TPST1_HUMAN
Protein-tyrosine sulfotransferase 1
Search

TPST1

0.97	Tyrosylprotein sulfotransferase 1

0.83	GO:0006478	peptidyl-tyrosine sulfation
0.35	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
0.34	GO:0006954	inflammatory response

0.83	GO:0008476	protein-tyrosine sulfotransferase activity
0.50	GO:0042803	protein homodimerization activity

0.53	GO:0030173	integral component of Golgi membrane
0.35	GO:0005783	endoplasmic reticulum

0.83

EC:2.8.2.20

GO:0008476

sp|O60508|PRP17_HUMAN
Pre-mRNA-processing factor 17
Search

CDC40

0.88	Cell division cycle 40

0.75	GO:0000398	mRNA splicing, via spliceosome
0.49	GO:0051301	cell division

0.36

GO:0003723

RNA binding

0.82	GO:0071013	catalytic step 2 spliceosome
0.64	GO:0005684	U2-type spliceosomal complex
0.30	GO:0031224	intrinsic component of membrane

sp|O60512|B4GT3_HUMAN
Beta-1,4-galactosyltransferase 3
Search

B4GALT3

0.97	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3

0.62	GO:0006682	galactosylceramide biosynthetic process
0.60	GO:0005975	carbohydrate metabolic process
0.40	GO:0006486	protein glycosylation
0.39	GO:0021680	cerebellar Purkinje cell layer development
0.39	GO:0008542	visual learning
0.39	GO:0007613	memory
0.38	GO:0007626	locomotory behavior
0.36	GO:0018146	keratan sulfate biosynthetic process

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.36	GO:0046872	metal ion binding

0.53	GO:0005794	Golgi apparatus
0.50	GO:0005829	cytosol
0.40	GO:0098588	bounding membrane of organelle
0.39	GO:0031984	organelle subcompartment
0.37	GO:0070062	extracellular exosome
0.36	GO:0005654	nucleoplasm
0.30	GO:0016021	integral component of membrane

0.65

GO:0016757

sp|O60513|B4GT4_HUMAN
Beta-1,4-galactosyltransferase 4
Search

B4GALT4

0.97	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4

0.60	GO:0005975	carbohydrate metabolic process
0.46	GO:0006682	galactosylceramide biosynthetic process
0.39	GO:0006486	protein glycosylation
0.36	GO:0018146	keratan sulfate biosynthetic process

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.35	GO:0046872	metal ion binding

0.53	GO:0005794	Golgi apparatus
0.40	GO:0005829	cytosol
0.38	GO:0098588	bounding membrane of organelle
0.38	GO:0031984	organelle subcompartment
0.33	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

0.65

GO:0016757

sp|O60516|4EBP3_HUMAN
Eukaryotic translation initiation factor 4E-binding protein 3
Search

0.92	Eukaryotic translation initiation factor 4E-binding protein 3

0.82	GO:0045947	negative regulation of translational initiation
0.61	GO:0006413	translational initiation
0.50	GO:0031929	TOR signaling
0.47	GO:0008286	insulin receptor signaling pathway
0.45	GO:0035176	social behavior
0.45	GO:0000082	G1/S transition of mitotic cell cycle
0.45	GO:0045931	positive regulation of mitotic cell cycle
0.44	GO:0007613	memory
0.44	GO:0019933	cAMP-mediated signaling
0.44	GO:0048167	regulation of synaptic plasticity

0.86	GO:0008190	eukaryotic initiation factor 4E binding
0.61	GO:0003743	translation initiation factor activity
0.52	GO:0030371	translation repressor activity
0.36	GO:0005452	inorganic anion exchanger activity
0.35	GO:0051721	protein phosphatase 2A binding

0.43	GO:0005829	cytosol
0.36	GO:0016281	eukaryotic translation initiation factor 4F complex
0.33	GO:0005634	nucleus
0.30	GO:0016020	membrane

sp|O60518|RNBP6_HUMAN
Ran-binding protein 6
Search

IPO5

0.91	Ran-binding protein 6

0.70	GO:0006610	ribosomal protein import into nucleus
0.69	GO:0006886	intracellular protein transport
0.69	GO:0006607	NLS-bearing protein import into nucleus
0.58	GO:0042307	positive regulation of protein import into nucleus
0.58	GO:0071230	cellular response to amino acid stimulus
0.37	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
0.37	GO:0034260	negative regulation of GTPase activity
0.34	GO:0016032	viral process

0.77	GO:0008536	Ran GTPase binding
0.61	GO:0008139	nuclear localization sequence binding
0.58	GO:0008565	protein transporter activity
0.37	GO:0005095	GTPase inhibitor activity
0.36	GO:0003723	RNA binding

0.58	GO:0034399	nuclear periphery
0.58	GO:0031965	nuclear membrane
0.43	GO:0005737	cytoplasm
0.36	GO:0005643	nuclear pore
0.35	GO:0005730	nucleolus
0.35	GO:0097708	intracellular vesicle

sp|O60519|CRBL2_HUMAN
cAMP-responsive element-binding protein-like 2
Search

CREBL2

0.97	cAMP responsive element binding protein like 2

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.41	GO:0046326	positive regulation of glucose import
0.41	GO:0045600	positive regulation of fat cell differentiation
0.41	GO:1902680	positive regulation of RNA biosynthetic process
0.40	GO:0046889	positive regulation of lipid biosynthetic process
0.40	GO:0038202	TORC1 signaling
0.39	GO:0044246	regulation of multicellular organismal metabolic process
0.39	GO:0033138	positive regulation of peptidyl-serine phosphorylation

0.61	GO:0003700	DNA binding transcription factor activity
0.38	GO:0003682	chromatin binding
0.37	GO:0042803	protein homodimerization activity
0.37	GO:0046982	protein heterodimerization activity
0.35	GO:0003677	DNA binding

0.38	GO:0005634	nucleus
0.33	GO:0043233	organelle lumen
0.33	GO:0044446	intracellular organelle part
0.30	GO:0031224	intrinsic component of membrane

sp|O60522|TDRD6_HUMAN
Tudor domain-containing protein 6
Search

TDRD6

0.89	Tudor domain-containing protein 6

0.70	GO:0007283	spermatogenesis
0.70	GO:0007281	germ cell development
0.53	GO:0007275	multicellular organism development

0.50	GO:0005515	protein binding
0.35	GO:0005509	calcium ion binding
0.34	GO:0003723	RNA binding
0.33	GO:0004386	helicase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0008144	drug binding

0.78	GO:0033391	chromatoid body
0.75	GO:0043186	P granule
0.62	GO:0005783	endoplasmic reticulum
0.52	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O60524|NEMF_HUMAN
Nuclear export mediator factor NEMF
Search

NEMF

0.92	Nuclear export mediator factor NEMF

0.75

GO:0051168

nuclear export

0.34

GO:0005515

protein binding

0.38

GO:0005634

nucleus

sp|O60542|PSPN_HUMAN
Persephin
Search

PSPN

0.96

Persephin

0.76	GO:0010469	regulation of receptor activity
0.50	GO:0031175	neuron projection development
0.49	GO:0009888	tissue development
0.48	GO:0016477	cell migration
0.48	GO:0048513	animal organ development
0.46	GO:0050930	induction of positive chemotaxis
0.45	GO:0021675	nerve development
0.45	GO:0048667	cell morphogenesis involved in neuron differentiation
0.45	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.45	GO:0048864	stem cell development

0.78	GO:0008083	growth factor activity
0.39	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.36	GO:0030116	glial cell-derived neurotrophic factor receptor binding
0.33	GO:0008373	sialyltransferase activity
0.33	GO:0003676	nucleic acid binding

0.66	GO:0005576	extracellular region
0.34	GO:0030424	axon
0.33	GO:0005622	intracellular
0.33	GO:0043227	membrane-bounded organelle

0.33

GO:0008373

sp|O60543|CIDEA_HUMAN
Cell death activator CIDE-A
Search

CIDEA

0.91	Cell death activator CIDE-A

0.78	GO:0006915	apoptotic process
0.76	GO:0019915	lipid storage
0.44	GO:0034389	lipid particle organization
0.43	GO:0035634	response to stilbenoid
0.42	GO:1902510	regulation of apoptotic DNA fragmentation
0.42	GO:0010890	positive regulation of sequestering of triglyceride
0.42	GO:1900118	negative regulation of execution phase of apoptosis
0.42	GO:0050995	negative regulation of lipid catabolic process
0.42	GO:0001659	temperature homeostasis
0.42	GO:0032720	negative regulation of tumor necrosis factor production

0.39

GO:0042803

protein homodimerization activity

0.76	GO:0005811	lipid droplet
0.39	GO:0005829	cytosol
0.39	GO:0005634	nucleus
0.38	GO:0005783	endoplasmic reticulum
0.37	GO:0005740	mitochondrial envelope

sp|O60547|GMDS_HUMAN
GDP-mannose 4,6 dehydratase
Search

GMDS

0.48	Gdp mannose 46 dehydratase

0.79	GO:0019673	GDP-mannose metabolic process
0.56	GO:0042351	'de novo' GDP-L-fucose biosynthetic process
0.52	GO:0007219	Notch signaling pathway
0.49	GO:0021744	dorsal motor nucleus of vagus nerve development
0.49	GO:0021564	vagus nerve development
0.47	GO:0010842	retina layer formation
0.45	GO:0036065	fucosylation
0.31	GO:0006468	protein phosphorylation

0.81	GO:0008446	GDP-mannose 4,6-dehydratase activity
0.55	GO:0070401	NADP+ binding
0.49	GO:0042802	identical protein binding
0.45	GO:0008417	fucosyltransferase activity
0.31	GO:0004672	protein kinase activity
0.31	GO:0005524	ATP binding

0.37	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.81	EC:4.2.1.47	GO:0008446
0.81	KEGG:R00888	GO:0008446

sp|O60548|FOXD2_HUMAN
Forkhead box protein D2
Search

FOXD2

0.92	Forkhead box protein D2

0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.56	GO:1902680	positive regulation of RNA biosynthetic process
0.50	GO:0030154	cell differentiation
0.49	GO:0009653	anatomical structure morphogenesis
0.44	GO:0072127	renal capsule development
0.43	GO:0072076	nephrogenic mesenchyme development
0.42	GO:0072268	pattern specification involved in metanephros development
0.42	GO:0032275	luteinizing hormone secretion

0.65	GO:0043565	sequence-specific DNA binding
0.61	GO:0003700	DNA binding transcription factor activity
0.43	GO:0001012	RNA polymerase II regulatory region DNA binding
0.41	GO:0003690	double-stranded DNA binding
0.41	GO:0008301	DNA binding, bending
0.32	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.38	GO:0000785	chromatin
0.37	GO:0043233	organelle lumen
0.32	GO:0005667	transcription factor complex

sp|O60551|NMT2_HUMAN
Glycylpeptide N-tetradecanoyltransferase 2
Search

NMT2

0.74	Glycylpeptide N-tetradecanoyltransferase

0.85	GO:0006499	N-terminal protein myristoylation
0.55	GO:0018201	peptidyl-glycine modification
0.36	GO:0001701	in utero embryonic development
0.36	GO:0022400	regulation of rhodopsin mediated signaling pathway
0.36	GO:0042180	cellular ketone metabolic process
0.34	GO:0075733	intracellular transport of virus

0.85	GO:0004379	glycylpeptide N-tetradecanoyltransferase activity
0.36	GO:0000062	fatty-acyl-CoA binding

0.47	GO:0019898	extrinsic component of membrane
0.45	GO:0005794	Golgi apparatus
0.45	GO:0005829	cytosol
0.40	GO:0005886	plasma membrane
0.33	GO:0044216	other organism cell
0.33	GO:0018995	host
0.30	GO:0016021	integral component of membrane

0.85

EC:2.3.1.97

GO:0004379

sp|O60563|CCNT1_HUMAN
Cyclin-T1
Search

CCNT2

0.80	Putative cdk9 kinase-activating protein cyclin t

0.65	GO:1900364	negative regulation of mRNA polyadenylation
0.59	GO:0045944	positive regulation of transcription by RNA polymerase II
0.58	GO:0006351	transcription, DNA-templated
0.53	GO:1901409	positive regulation of phosphorylation of RNA polymerase II C-terminal domain
0.51	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
0.49	GO:0006468	protein phosphorylation
0.47	GO:0019085	early viral transcription
0.46	GO:0019086	late viral transcription
0.43	GO:0007519	skeletal muscle tissue development
0.40	GO:0051301	cell division

0.69	GO:0097322	7SK snRNA binding
0.60	GO:0070063	RNA polymerase binding
0.59	GO:0003682	chromatin binding
0.57	GO:0019901	protein kinase binding
0.57	GO:0008134	transcription factor binding
0.56	GO:0044212	transcription regulatory region DNA binding
0.50	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.35	GO:0004674	protein serine/threonine kinase activity

0.67	GO:0008024	cyclin/CDK positive transcription elongation factor complex
0.42	GO:0048471	perinuclear region of cytoplasm
0.40	GO:0005829	cytosol
0.38	GO:0005730	nucleolus
0.37	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.50

GO:0016538

sp|O60565|GREM1_HUMAN
Gremlin-1
Search

GREM1

0.97	Gremlin 1, DAN family BMP antagonist

0.74	GO:0010469	regulation of receptor activity
0.68	GO:0090291	negative regulation of osteoclast proliferation
0.68	GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis
0.68	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation
0.68	GO:0003257	positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
0.67	GO:1900155	negative regulation of bone trabecula formation
0.67	GO:0060676	ureteric bud formation
0.67	GO:0048263	determination of dorsal identity
0.67	GO:1900158	negative regulation of bone mineralization involved in bone maturation
0.67	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis

0.77	GO:0005125	cytokine activity
0.68	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
0.68	GO:0043184	vascular endothelial growth factor receptor 2 binding
0.66	GO:0036122	BMP binding
0.57	GO:0042803	protein homodimerization activity
0.40	GO:0016015	morphogen activity
0.39	GO:0008201	heparin binding
0.37	GO:0043395	heparan sulfate proteoglycan binding

0.72	GO:0005615	extracellular space
0.57	GO:0009986	cell surface
0.30	GO:0016020	membrane

sp|O60566|BUB1B_HUMAN
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Search

BUB1B

0.92	LOW QUALITY PROTEIN: mitotic checkpoint serine/threonine-protein kinase BUB1 beta

0.82	GO:0007094	mitotic spindle assembly checkpoint
0.69	GO:0007091	metaphase/anaphase transition of mitotic cell cycle
0.65	GO:0034501	protein localization to kinetochore
0.58	GO:0006468	protein phosphorylation
0.56	GO:0051754	meiotic sister chromatid cohesion, centromeric
0.39	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
0.39	GO:0006915	apoptotic process
0.39	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
0.38	GO:0031145	anaphase-promoting complex-dependent catabolic process
0.38	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process

0.59	GO:0004672	protein kinase activity
0.50	GO:0032559	adenyl ribonucleotide binding
0.49	GO:0008144	drug binding
0.49	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0005515	protein binding
0.36	GO:0005509	calcium ion binding

0.63	GO:0000778	condensed nuclear chromosome kinetochore
0.63	GO:0000940	condensed chromosome outer kinetochore
0.61	GO:0048471	perinuclear region of cytoplasm
0.54	GO:0005829	cytosol
0.38	GO:0051233	spindle midzone
0.37	GO:0005680	anaphase-promoting complex
0.37	GO:0005815	microtubule organizing center
0.30	GO:0016020	membrane

sp|O60568|PLOD3_HUMAN
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
Search

PLOD3

0.93	Procollagen lysine 2-oxoglutarate 5-dioxygenase 3

0.63	GO:0046947	hydroxylysine biosynthetic process
0.62	GO:0017185	peptidyl-lysine hydroxylation
0.57	GO:0001886	endothelial cell morphogenesis
0.57	GO:0070831	basement membrane assembly
0.56	GO:0008544	epidermis development
0.55	GO:0042311	vasodilation
0.55	GO:0060425	lung morphogenesis
0.55	GO:0032963	collagen metabolic process
0.55	GO:0030199	collagen fibril organization
0.54	GO:0021915	neural tube development

0.85	GO:0008475	procollagen-lysine 5-dioxygenase activity
0.77	GO:0031418	L-ascorbic acid binding
0.62	GO:0005506	iron ion binding
0.60	GO:0033823	procollagen glucosyltransferase activity
0.36	GO:0050211	procollagen galactosyltransferase activity
0.34	GO:0005515	protein binding
0.33	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

0.69	GO:0005783	endoplasmic reticulum
0.52	GO:0005802	trans-Golgi network
0.50	GO:0031012	extracellular matrix
0.39	GO:0005581	collagen trimer
0.39	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.39	GO:0098588	bounding membrane of organelle
0.38	GO:1902494	catalytic complex
0.37	GO:0070062	extracellular exosome
0.30	GO:0016021	integral component of membrane

0.85

EC:1.14.11.4

GO:0008475

sp|O60573|IF4E2_HUMAN
Eukaryotic translation initiation factor 4E type 2
Search

EIF4E2

0.78	Eukaryotic translation initiation factor 4E

0.72	GO:0006413	translational initiation
0.49	GO:0001701	in utero embryonic development
0.47	GO:0017148	negative regulation of translation
0.34	GO:0055114	oxidation-reduction process

0.73	GO:0003743	translation initiation factor activity
0.48	GO:0031625	ubiquitin protein ligase binding
0.37	GO:0005509	calcium ion binding
0.36	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
0.35	GO:0020037	heme binding
0.35	GO:0005506	iron ion binding
0.34	GO:0000339	RNA cap binding

0.51	GO:0005845	mRNA cap binding complex
0.49	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.36

GO:0016705

sp|O60575|ISK4_HUMAN
Serine protease inhibitor Kazal-type 4
Search

SPINK4

0.89	Serine protease inhibitor Kazal-type 4

0.60	GO:0010951	negative regulation of endopeptidase activity
0.49	GO:0042493	response to drug
0.48	GO:0006508	proteolysis
0.47	GO:0043113	receptor clustering
0.45	GO:1903831	signal transduction involved in cellular response to ammonium ion
0.43	GO:0032870	cellular response to hormone stimulus
0.42	GO:1901701	cellular response to oxygen-containing compound
0.41	GO:0007186	G-protein coupled receptor signaling pathway
0.38	GO:0007034	vacuolar transport
0.37	GO:1902572	negative regulation of serine-type peptidase activity

0.62	GO:0004867	serine-type endopeptidase inhibitor activity
0.49	GO:0008233	peptidase activity
0.46	GO:0043236	laminin binding
0.42	GO:0005509	calcium ion binding
0.34	GO:0008270	zinc ion binding

0.46	GO:0005576	extracellular region
0.38	GO:0005886	plasma membrane
0.36	GO:0001669	acrosomal vesicle
0.36	GO:0005581	collagen trimer
0.35	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.49

GO:0008233

sp|O60583|CCNT2_HUMAN
Cyclin-T2
Search

CCNT2

0.97	LOW QUALITY PROTEIN: cyclin-T2

0.62	GO:0019085	early viral transcription
0.61	GO:0019086	late viral transcription
0.58	GO:0006351	transcription, DNA-templated
0.56	GO:0007519	skeletal muscle tissue development
0.54	GO:0045944	positive regulation of transcription by RNA polymerase II
0.50	GO:1901409	positive regulation of phosphorylation of RNA polymerase II C-terminal domain
0.49	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
0.40	GO:0051147	regulation of muscle cell differentiation
0.35	GO:0016073	snRNA metabolic process
0.35	GO:0051301	cell division

0.60	GO:0097322	7SK snRNA binding
0.59	GO:0001223	transcription coactivator binding
0.53	GO:0070063	RNA polymerase binding
0.53	GO:0003682	chromatin binding
0.48	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
0.39	GO:0019901	protein kinase binding
0.34	GO:0004674	protein serine/threonine kinase activity
0.33	GO:0044212	transcription regulatory region DNA binding
0.32	GO:0016787	hydrolase activity

0.59	GO:0008024	cyclin/CDK positive transcription elongation factor complex
0.54	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0005829	cytosol
0.42	GO:0005886	plasma membrane

0.48

GO:0016538

sp|O60602|TLR5_HUMAN
Toll-like receptor 5
Search

TLR5

0.93	Toll like receptor 5

0.86	GO:0034146	toll-like receptor 5 signaling pathway
0.84	GO:0002755	MyD88-dependent toll-like receptor signaling pathway
0.82	GO:0050707	regulation of cytokine secretion
0.81	GO:0001819	positive regulation of cytokine production
0.79	GO:0045087	innate immune response
0.78	GO:0042742	defense response to bacterium
0.48	GO:0034123	positive regulation of toll-like receptor signaling pathway
0.47	GO:0032677	regulation of interleukin-8 production
0.47	GO:0071260	cellular response to mechanical stimulus
0.40	GO:0006954	inflammatory response

0.70	GO:0004888	transmembrane signaling receptor activity
0.48	GO:0005149	interleukin-1 receptor binding

0.32	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O60603|TLR2_HUMAN
Toll-like receptor 2
Search

TLR2

0.87	Toll like receptor

0.86	GO:0034134	toll-like receptor 2 signaling pathway
0.84	GO:0050729	positive regulation of inflammatory response
0.84	GO:0002755	MyD88-dependent toll-like receptor signaling pathway
0.82	GO:0050707	regulation of cytokine secretion
0.82	GO:0002237	response to molecule of bacterial origin
0.80	GO:0006954	inflammatory response
0.79	GO:0045087	innate immune response
0.57	GO:0071216	cellular response to biotic stimulus
0.57	GO:0002374	cytokine secretion involved in immune response
0.56	GO:0032613	interleukin-10 production

0.57	GO:0042497	triacyl lipopeptide binding
0.55	GO:0035325	Toll-like receptor binding
0.54	GO:0008329	signaling pattern recognition receptor activity
0.52	GO:0001530	lipopolysaccharide binding
0.50	GO:0042834	peptidoglycan binding
0.49	GO:0032403	protein complex binding
0.48	GO:0046982	protein heterodimerization activity
0.39	GO:0042498	diacyl lipopeptide binding
0.38	GO:0070891	lipoteichoic acid binding

0.57	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex
0.56	GO:0098857	membrane microdomain
0.51	GO:0005794	Golgi apparatus
0.50	GO:0030670	phagocytic vesicle membrane
0.49	GO:0009986	cell surface
0.47	GO:0031226	intrinsic component of plasma membrane
0.39	GO:0106003	amyloid-beta complex
0.39	GO:0044297	cell body
0.39	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex
0.37	GO:0042995	cell projection

sp|O60609|GFRA3_HUMAN
GDNF family receptor alpha-3
Search

GFRA3

0.90	GDNF family receptor alpha-3 variant

0.73	GO:0048485	sympathetic nervous system development
0.69	GO:0001764	neuron migration
0.67	GO:0007411	axon guidance
0.39	GO:0007422	peripheral nervous system development
0.38	GO:0000165	MAPK cascade
0.38	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
0.36	GO:0065009	regulation of molecular function
0.35	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein

0.75	GO:0008046	axon guidance receptor activity
0.38	GO:0015026	coreceptor activity
0.38	GO:0005088	Ras guanyl-nucleotide exchange factor activity
0.37	GO:0005102	receptor binding

0.68	GO:0009897	external side of plasma membrane
0.58	GO:0005829	cytosol
0.48	GO:0031225	anchored component of membrane
0.38	GO:0019898	extrinsic component of membrane
0.30	GO:0016021	integral component of membrane

sp|O60610|DIAP1_HUMAN
Protein diaphanous homolog 1
Search

DIAPH1

0.92	Diaphanous homologue

0.82	GO:0030041	actin filament polymerization
0.59	GO:0071420	cellular response to histamine
0.58	GO:0035372	protein localization to microtubule
0.56	GO:0051279	regulation of release of sequestered calcium ion into cytosol
0.53	GO:0032886	regulation of microtubule-based process
0.51	GO:0051493	regulation of cytoskeleton organization
0.48	GO:0008360	regulation of cell shape
0.42	GO:0007292	female gamete generation
0.40	GO:0030335	positive regulation of cell migration
0.39	GO:0007605	sensory perception of sound

0.77	GO:0017048	Rho GTPase binding
0.74	GO:0003779	actin binding
0.55	GO:0044325	ion channel binding
0.40	GO:0005522	profilin binding
0.37	GO:0042802	identical protein binding
0.35	GO:0005102	receptor binding
0.35	GO:0003723	RNA binding

0.53	GO:0072686	mitotic spindle
0.41	GO:0032587	ruffle membrane
0.39	GO:0005903	brush border
0.38	GO:0101003	ficolin-1-rich granule membrane
0.38	GO:0043005	neuron projection
0.38	GO:0005815	microtubule organizing center
0.35	GO:0005829	cytosol
0.35	GO:0005876	spindle microtubule
0.33	GO:0005730	nucleolus
0.33	GO:0005783	endoplasmic reticulum

sp|O60613|SEP15_HUMAN
Selenoprotein F
Search

SELENOF

0.92	15 kDa selenoprotein (inferred by orthology to a zebrafish protein)

0.66	GO:0051084	'de novo' posttranslational protein folding
0.53	GO:0035092	sperm chromatin condensation
0.45	GO:0098869	cellular oxidant detoxification

0.59	GO:0008430	selenium binding
0.50	GO:0008379	thioredoxin peroxidase activity
0.48	GO:0005515	protein binding

0.84	GO:0005788	endoplasmic reticulum lumen
0.59	GO:0070062	extracellular exosome

0.50

EC:1.11.1

GO:0008379

sp|O60635|TSN1_HUMAN
Tetraspanin-1
Search

TSPAN1

0.55	Tetraspanin

0.58	GO:0045807	positive regulation of endocytosis
0.57	GO:0031647	regulation of protein stability
0.56	GO:0008283	cell proliferation
0.55	GO:0016477	cell migration
0.45	GO:0007166	cell surface receptor signaling pathway
0.44	GO:0043126	regulation of 1-phosphatidylinositol 4-kinase activity
0.43	GO:0071404	cellular response to low-density lipoprotein particle stimulus
0.42	GO:0090218	positive regulation of lipid kinase activity
0.42	GO:1904352	positive regulation of protein catabolic process in the vacuole
0.42	GO:0031623	receptor internalization

0.42	GO:1990459	transferrin receptor binding
0.41	GO:0001618	virus receptor activity
0.34	GO:0023026	MHC class II protein complex binding

0.55	GO:0048471	perinuclear region of cytoplasm
0.53	GO:0030054	cell junction
0.53	GO:0031982	vesicle
0.51	GO:0005654	nucleoplasm
0.45	GO:0005886	plasma membrane
0.42	GO:0043230	extracellular organelle
0.42	GO:0005765	lysosomal membrane
0.40	GO:0005615	extracellular space
0.32	GO:0045177	apical part of cell
0.30	GO:0031224	intrinsic component of membrane

sp|O60636|TSN2_HUMAN
Tetraspanin-2
Search

TSPAN2

0.59	Tetraspanin

0.62	GO:0014005	microglia development
0.59	GO:0014002	astrocyte development
0.58	GO:0048709	oligodendrocyte differentiation
0.58	GO:0042552	myelination
0.55	GO:0006954	inflammatory response
0.55	GO:0061564	axon development
0.45	GO:0007166	cell surface receptor signaling pathway
0.38	GO:0007420	brain development
0.36	GO:0090331	negative regulation of platelet aggregation
0.36	GO:0071404	cellular response to low-density lipoprotein particle stimulus

0.33

GO:0005515

protein binding

0.56	GO:0043209	myelin sheath
0.44	GO:0005886	plasma membrane
0.35	GO:0070062	extracellular exosome
0.34	GO:0009986	cell surface
0.34	GO:0098552	side of membrane
0.30	GO:0016021	integral component of membrane

sp|O60637|TSN3_HUMAN
Tetraspanin-3
Search

TSPAN3

0.59	Tetraspanin

0.43

GO:0007166

cell surface receptor signaling pathway

0.42	GO:0005887	integral component of plasma membrane
0.36	GO:0070062	extracellular exosome

sp|O60641|AP180_HUMAN
Clathrin coat assembly protein AP180
Search

SNAP91

0.86	Synaptosomal-associated protein 91

0.83	GO:0048268	clathrin coat assembly
0.70	GO:2000369	regulation of clathrin-dependent endocytosis

0.84	GO:0005545	1-phosphatidylinositol binding
0.81	GO:0030276	clathrin binding

0.80

GO:0030136

clathrin-coated vesicle

sp|O60645|EXOC3_HUMAN
Exocyst complex component 3
Search

EXOC3

0.90	Exocyst complex component 3

0.74	GO:0006887	exocytosis
0.48	GO:0051601	exocyst localization
0.37	GO:0015031	protein transport

0.53	GO:0045296	cadherin binding
0.45	GO:0000149	SNARE binding

0.75	GO:0000145	exocyst
0.39	GO:0030426	growth cone
0.39	GO:0030496	midbody
0.38	GO:0048471	perinuclear region of cytoplasm
0.37	GO:0030667	secretory granule membrane
0.37	GO:0005794	Golgi apparatus
0.34	GO:0005829	cytosol

sp|O60656|UD19_HUMAN
UDP-glucuronosyltransferase 1-9
Search

0.54	UDP-glucuronosyltransferase

0.58	GO:0052695	cellular glucuronidation
0.54	GO:0009812	flavonoid metabolic process
0.50	GO:0006805	xenobiotic metabolic process
0.48	GO:2001030	negative regulation of cellular glucuronidation
0.47	GO:1904223	regulation of glucuronosyltransferase activity
0.44	GO:0043086	negative regulation of catalytic activity
0.44	GO:0045922	negative regulation of fatty acid metabolic process
0.41	GO:0042440	pigment metabolic process
0.41	GO:0009804	coumarin metabolic process
0.41	GO:0042573	retinoic acid metabolic process

0.79	GO:0015020	glucuronosyltransferase activity
0.48	GO:0042803	protein homodimerization activity
0.48	GO:0001972	retinoic acid binding
0.48	GO:0046982	protein heterodimerization activity
0.46	GO:0019899	enzyme binding
0.44	GO:0005496	steroid binding
0.43	GO:0004857	enzyme inhibitor activity
0.41	GO:0005504	fatty acid binding
0.35	GO:0008144	drug binding

0.48	GO:0005783	endoplasmic reticulum
0.44	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.43	GO:0031984	organelle subcompartment
0.38	GO:0005887	integral component of plasma membrane
0.37	GO:0070062	extracellular exosome
0.36	GO:0043234	protein complex
0.33	GO:0031966	mitochondrial membrane
0.33	GO:0019866	organelle inner membrane

0.79

EC:2.4.1.17

GO:0015020

sp|O60658|PDE8A_HUMAN
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Search

PDE8A

0.56	Phosphodiesterase

0.60	GO:0007165	signal transduction
0.54	GO:0071364	cellular response to epidermal growth factor stimulus
0.53	GO:0070374	positive regulation of ERK1 and ERK2 cascade
0.52	GO:1903206	negative regulation of hydrogen peroxide-induced cell death
0.48	GO:1903506	regulation of nucleic acid-templated transcription
0.48	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.47	GO:0010468	regulation of gene expression
0.37	GO:0006198	cAMP catabolic process

0.79	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
0.54	GO:0046872	metal ion binding
0.48	GO:0019900	kinase binding

0.36	GO:0070062	extracellular exosome
0.34	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:3.1.4.17

GO:0004114

sp|O60662|KLH41_HUMAN
Kelch-like protein 41
Search

KLHL41

0.97	Kelch repeat and BTB domain-containing protein 10

0.85	GO:0048741	skeletal muscle fiber development
0.80	GO:0035914	skeletal muscle cell differentiation
0.79	GO:0045214	sarcomere organization
0.57	GO:2000291	regulation of myoblast proliferation
0.56	GO:2001014	regulation of skeletal muscle cell differentiation
0.55	GO:0045661	regulation of myoblast differentiation
0.55	GO:0031397	negative regulation of protein ubiquitination
0.51	GO:0016567	protein ubiquitination
0.40	GO:0031275	regulation of lateral pseudopodium assembly
0.39	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process

0.44	GO:0004842	ubiquitin-protein transferase activity
0.37	GO:0032266	phosphatidylinositol-3-phosphate binding
0.35	GO:0005515	protein binding
0.33	GO:0004252	serine-type endopeptidase activity

0.57	GO:0031672	A band
0.56	GO:0033017	sarcoplasmic reticulum membrane
0.56	GO:0031463	Cul3-RING ubiquitin ligase complex
0.48	GO:0005856	cytoskeleton
0.47	GO:0005829	cytosol
0.45	GO:0034464	BBSome
0.44	GO:0005634	nucleus
0.41	GO:0005886	plasma membrane
0.39	GO:0031674	I band
0.39	GO:0031143	pseudopodium

0.33	EC:3.4.21	GO:0004252
0.44	KEGG:R03876	GO:0004842

sp|O60663|LMX1B_HUMAN
LIM homeobox transcription factor 1-beta
Search

LMX1B

0.96	LIM homeobox transcription factor 1-beta

0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.54	GO:0030902	hindbrain development
0.52	GO:0071542	dopaminergic neuron differentiation
0.51	GO:0030901	midbrain development
0.51	GO:0042048	olfactory behavior
0.50	GO:0021542	dentate gyrus development
0.50	GO:0007613	memory
0.49	GO:0021953	central nervous system neuron differentiation

0.63	GO:0043565	sequence-specific DNA binding
0.53	GO:0046872	metal ion binding
0.49	GO:0003700	DNA binding transcription factor activity
0.48	GO:0001012	RNA polymerase II regulatory region DNA binding
0.46	GO:0003690	double-stranded DNA binding
0.35	GO:0005515	protein binding

0.60

GO:0005634

nucleus

sp|O60664|PLIN3_HUMAN
Perilipin-3
Search

PLIN3

0.89

Perilipin

0.54	GO:0010897	negative regulation of triglyceride catabolic process
0.54	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway
0.54	GO:0031999	negative regulation of fatty acid beta-oxidation
0.53	GO:0010890	positive regulation of sequestering of triglyceride
0.53	GO:0032000	positive regulation of fatty acid beta-oxidation
0.53	GO:0010867	positive regulation of triglyceride biosynthetic process
0.53	GO:0060192	negative regulation of lipase activity
0.52	GO:0034389	lipid particle organization
0.52	GO:2000378	negative regulation of reactive oxygen species metabolic process
0.50	GO:0019915	lipid storage

0.75	GO:0045296	cadherin binding
0.53	GO:0035473	lipase binding
0.46	GO:0042802	identical protein binding

0.82	GO:0005811	lipid droplet
0.67	GO:0005829	cytosol
0.47	GO:0010008	endosome membrane
0.39	GO:0030133	transport vesicle
0.38	GO:0005794	Golgi apparatus
0.36	GO:0005739	mitochondrion

sp|O60667|FAIM3_HUMAN
Fas apoptotic inhibitory molecule 3
Search

FCMR

0.97	Fc fragment of IgM receptor

0.30

GO:0044425

membrane part

sp|O60669|MOT2_HUMAN
Monocarboxylate transporter 2
Search

SLC16A7

0.81	Solute carrier family 16, member 7 (Monocarboxylic acid transporter 2)

0.81	GO:1901475	pyruvate transmembrane transport
0.69	GO:0035873	lactate transmembrane transport
0.37	GO:0051780	behavioral response to nutrient
0.37	GO:0032094	response to food
0.36	GO:0050796	regulation of insulin secretion
0.36	GO:0007098	centrosome cycle
0.36	GO:0042593	glucose homeostasis
0.36	GO:0071407	cellular response to organic cyclic compound
0.34	GO:0006629	lipid metabolic process

0.76	GO:0008028	monocarboxylic acid transmembrane transporter activity
0.67	GO:1901618	organic hydroxy compound transmembrane transporter activity
0.35	GO:0042803	protein homodimerization activity
0.32	GO:0097159	organic cyclic compound binding

0.67	GO:0005887	integral component of plasma membrane
0.36	GO:0005813	centrosome
0.35	GO:0030054	cell junction
0.34	GO:0005739	mitochondrion

sp|O60671|RAD1_HUMAN
Cell cycle checkpoint protein RAD1
Search

RAD1

0.93	Cell cycle checkpoint protein RAD1

0.81	GO:0000077	DNA damage checkpoint
0.60	GO:0051598	meiotic recombination checkpoint
0.58	GO:0071479	cellular response to ionizing radiation
0.49	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.43	GO:0006281	DNA repair
0.38	GO:0021762	substantia nigra development
0.35	GO:1901796	regulation of signal transduction by p53 class mediator
0.33	GO:0006260	DNA replication

0.53	GO:0008408	3'-5' exonuclease activity
0.46	GO:0003684	damaged DNA binding
0.39	GO:0008853	exodeoxyribonuclease III activity
0.33	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.51	GO:0031974	membrane-enclosed lumen
0.51	GO:0005694	chromosome
0.45	GO:0044446	intracellular organelle part
0.41	GO:0043234	protein complex

0.39

EC:3.1.11.2

GO:0008853

sp|O60673|REV3L_HUMAN
DNA polymerase zeta catalytic subunit
Search

REV3L

0.92	DNA polymerase zeta catalytic subunit

0.82	GO:0019985	translesion synthesis
0.63	GO:0090305	nucleic acid phosphodiester bond hydrolysis
0.39	GO:0006260	DNA replication

0.70	GO:0008408	3'-5' exonuclease activity
0.69	GO:0003887	DNA-directed DNA polymerase activity
0.54	GO:0003677	DNA binding
0.52	GO:1901265	nucleoside phosphate binding
0.50	GO:0036094	small molecule binding
0.38	GO:0051539	4 iron, 4 sulfur cluster binding
0.36	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding

0.84	GO:0016035	zeta DNA polymerase complex
0.54	GO:0005730	nucleolus
0.35	GO:0005654	nucleoplasm

0.69

GO:0003887

sp|O60674|JAK2_HUMAN
Tyrosine-protein kinase JAK2
Search

JAK2

0.58	Tyrosine-protein kinase

0.77	GO:0018108	peptidyl-tyrosine phosphorylation
0.63	GO:0035556	intracellular signal transduction
0.59	GO:0035722	interleukin-12-mediated signaling pathway
0.58	GO:0060396	growth hormone receptor signaling pathway
0.58	GO:0016572	histone phosphorylation
0.56	GO:0033209	tumor necrosis factor-mediated signaling pathway
0.56	GO:0010811	positive regulation of cell-substrate adhesion
0.54	GO:0050727	regulation of inflammatory response
0.51	GO:0046677	response to antibiotic
0.50	GO:0030218	erythrocyte differentiation

0.81	GO:0004715	non-membrane spanning protein tyrosine kinase activity
0.75	GO:0042393	histone binding
0.59	GO:0035173	histone kinase activity
0.57	GO:0042169	SH2 domain binding
0.55	GO:0030554	adenyl nucleotide binding
0.54	GO:0008144	drug binding
0.54	GO:0035639	purine ribonucleoside triphosphate binding
0.54	GO:0032555	purine ribonucleotide binding
0.52	GO:0019901	protein kinase binding
0.51	GO:0005102	receptor binding

0.68	GO:0005856	cytoskeleton
0.54	GO:0005925	focal adhesion
0.49	GO:0005654	nucleoplasm
0.47	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
0.39	GO:0016363	nuclear matrix
0.39	GO:0005737	cytoplasm
0.38	GO:0005901	caveola
0.38	GO:0012505	endomembrane system
0.34	GO:0097708	intracellular vesicle

0.81

EC:2.7.10.2

GO:0004715

sp|O60675|MAFK_HUMAN
Transcription factor MafK
Search

MAFK

0.92	Transcription factor MafK

0.57	GO:0006351	transcription, DNA-templated
0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.42	GO:0051253	negative regulation of RNA metabolic process
0.42	GO:0010558	negative regulation of macromolecule biosynthetic process
0.42	GO:0031327	negative regulation of cellular biosynthetic process
0.40	GO:0007399	nervous system development
0.38	GO:0051254	positive regulation of RNA metabolic process
0.38	GO:0010557	positive regulation of macromolecule biosynthetic process

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding
0.45	GO:0071535	RING-like zinc finger domain binding
0.42	GO:0001067	regulatory region nucleic acid binding
0.41	GO:0001221	transcription cofactor binding
0.38	GO:0046982	protein heterodimerization activity

0.61	GO:0005634	nucleus
0.40	GO:0031974	membrane-enclosed lumen
0.38	GO:0005667	transcription factor complex
0.37	GO:0044446	intracellular organelle part

sp|O60676|CST8_HUMAN
Cystatin-8
Search

CST8

0.70

Cystatin

0.76	GO:0010951	negative regulation of endopeptidase activity
0.56	GO:2000116	regulation of cysteine-type endopeptidase activity

0.83	GO:0004869	cysteine-type endopeptidase inhibitor activity
0.57	GO:0002020	protease binding

0.64	GO:0009986	cell surface
0.58	GO:0005576	extracellular region
0.44	GO:0005737	cytoplasm

sp|O60678|ANM3_HUMAN
Protein arginine N-methyltransferase 3
Search

PRMT3

0.95	Heterogeneous nuclear ribonucleoprotein methyltransferase-like 3 (S. cerevisiae)

0.73	GO:0008213	protein alkylation
0.67	GO:0043414	macromolecule methylation
0.57	GO:0018195	peptidyl-arginine modification
0.57	GO:0031397	negative regulation of protein ubiquitination
0.46	GO:0016570	histone modification
0.40	GO:1903506	regulation of nucleic acid-templated transcription
0.40	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.40	GO:0010468	regulation of gene expression
0.36	GO:0060997	dendritic spine morphogenesis
0.33	GO:0055114	oxidation-reduction process

0.63	GO:0008168	methyltransferase activity
0.45	GO:0140096	catalytic activity, acting on a protein
0.41	GO:0003676	nucleic acid binding
0.34	GO:0005515	protein binding
0.34	GO:0072341	modified amino acid binding
0.34	GO:0046872	metal ion binding
0.34	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
0.34	GO:0051287	NAD binding
0.32	GO:0004386	helicase activity
0.31	GO:0030554	adenyl nucleotide binding

0.50	GO:0005829	cytosol
0.45	GO:0005840	ribosome
0.33	GO:0019013	viral nucleocapsid
0.30	GO:0016020	membrane

0.63

GO:0008168

sp|O60682|MUSC_HUMAN
Musculin
Search

MSC

0.96	Activated B-cell factor 1

0.69	GO:0014707	branchiomeric skeletal muscle development
0.67	GO:0060539	diaphragm development
0.64	GO:0060021	palate development
0.60	GO:0000122	negative regulation of transcription by RNA polymerase II
0.57	GO:0072277	metanephric glomerular capillary formation
0.57	GO:0060435	bronchiole development
0.57	GO:0072162	metanephric mesenchymal cell differentiation
0.56	GO:0060426	lung vasculature development
0.55	GO:0060766	negative regulation of androgen receptor signaling pathway
0.55	GO:1990823	response to leukemia inhibitory factor

0.68	GO:0046983	protein dimerization activity
0.63	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.59	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
0.55	GO:0001158	enhancer sequence-specific DNA binding
0.55	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
0.54	GO:0043425	bHLH transcription factor binding
0.54	GO:0050681	androgen receptor binding
0.52	GO:0042826	histone deacetylase binding
0.52	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
0.51	GO:0000987	proximal promoter sequence-specific DNA binding

0.50	GO:0005634	nucleus
0.47	GO:0031974	membrane-enclosed lumen
0.43	GO:0044446	intracellular organelle part

sp|O60683|PEX10_HUMAN
Peroxisome biogenesis factor 10
Search

PEX10

0.94	Peroxisomal biogenesis factor 10

0.82	GO:0016558	protein import into peroxisome matrix
0.36	GO:0016567	protein ubiquitination
0.32	GO:0071712	ER-associated misfolded protein catabolic process
0.32	GO:0006436	tryptophanyl-tRNA aminoacylation
0.32	GO:0030433	ubiquitin-dependent ERAD pathway

0.63	GO:0008270	zinc ion binding
0.41	GO:0008022	protein C-terminus binding
0.35	GO:0016787	hydrolase activity
0.34	GO:0004842	ubiquitin-protein transferase activity
0.34	GO:0016874	ligase activity
0.32	GO:0044390	ubiquitin-like protein conjugating enzyme binding
0.32	GO:0061659	ubiquitin-like protein ligase activity
0.32	GO:0140101	catalytic activity, acting on a tRNA
0.31	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding

0.80	GO:0005779	integral component of peroxisomal membrane
0.35	GO:1990429	peroxisomal importomer complex
0.32	GO:0036513	Derlin-1 retrotranslocation complex

0.35	EC:3	GO:0016787
0.34	KEGG:R03876	GO:0004842

sp|O60684|IMA7_HUMAN
Importin subunit alpha-7
Search

KPNA6

0.61	Importin subunit alpha

0.80	GO:0006606	protein import into nucleus
0.53	GO:0060135	maternal process involved in female pregnancy
0.50	GO:0045944	positive regulation of transcription by RNA polymerase II
0.33	GO:0075733	intracellular transport of virus
0.33	GO:0044068	modulation by symbiont of host cellular process
0.33	GO:0019048	modulation by virus of host morphology or physiology

0.83	GO:0061608	nuclear import signal receptor activity
0.70	GO:0008565	protein transporter activity
0.51	GO:0008139	nuclear localization sequence binding
0.35	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.48	GO:0005737	cytoplasm
0.44	GO:0012505	endomembrane system
0.44	GO:0043233	organelle lumen
0.42	GO:0031967	organelle envelope
0.41	GO:0043234	protein complex
0.33	GO:0044216	other organism cell
0.33	GO:0018995	host
0.30	GO:0016020	membrane

sp|O60687|SRPX2_HUMAN
Sushi repeat-containing protein SRPX2
Search

SRPX2

0.97	Sushi repeat containing protein, X-linked 2

0.84	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis
0.83	GO:0071625	vocalization behavior
0.82	GO:0051965	positive regulation of synapse assembly
0.74	GO:0098609	cell-cell adhesion
0.70	GO:0042325	regulation of phosphorylation
0.68	GO:0048870	cell motility
0.51	GO:0060244	negative regulation of cell proliferation involved in contact inhibition
0.50	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
0.50	GO:0001845	phagolysosome assembly
0.49	GO:0001525	angiogenesis

0.87	GO:0036458	hepatocyte growth factor binding
0.70	GO:0042802	identical protein binding
0.69	GO:0005102	receptor binding

0.70	GO:0005615	extracellular space
0.51	GO:0060076	excitatory synapse
0.48	GO:0005737	cytoplasm
0.48	GO:0097060	synaptic membrane
0.47	GO:0009986	cell surface
0.46	GO:0030054	cell junction
0.42	GO:0012505	endomembrane system
0.39	GO:0043227	membrane-bounded organelle
0.38	GO:0043229	intracellular organelle
0.30	GO:0016021	integral component of membrane

sp|O60688|YPEL1_HUMAN
Protein yippee-like 1
Search

sp|O60701|UGDH_HUMAN
UDP-glucose 6-dehydrogenase
Search

UGDH

0.45	UDP-glucose 6-dehydrogenase

0.57	GO:0001702	gastrulation with mouth forming second
0.53	GO:0055114	oxidation-reduction process
0.47	GO:0003190	atrioventricular valve formation
0.46	GO:0045880	positive regulation of smoothened signaling pathway
0.45	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.45	GO:0007368	determination of left/right symmetry
0.45	GO:0006024	glycosaminoglycan biosynthetic process
0.43	GO:0006065	UDP-glucuronate biosynthetic process
0.35	GO:0000271	polysaccharide biosynthetic process
0.34	GO:0007509	mesoderm migration involved in gastrulation

0.77	GO:0003979	UDP-glucose 6-dehydrogenase activity
0.68	GO:0051287	NAD binding
0.33	GO:0009055	electron transfer activity

0.48	GO:0005654	nucleoplasm
0.44	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome
0.30	GO:0016020	membrane

0.77	EC:1.1.1.22	GO:0003979
0.77	KEGG:R00286	GO:0003979

sp|O60704|TPST2_HUMAN
Protein-tyrosine sulfotransferase 2
Search

TPST2

0.97	Tyrosylprotein sulfotransferase 2

0.84	GO:0006478	peptidyl-tyrosine sulfation
0.38	GO:0060468	prevention of polyspermy
0.37	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization
0.36	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process

0.84	GO:0008476	protein-tyrosine sulfotransferase activity
0.52	GO:0042803	protein homodimerization activity
0.32	GO:0003676	nucleic acid binding

0.50	GO:0012505	endomembrane system
0.44	GO:0043231	intracellular membrane-bounded organelle
0.43	GO:0044444	cytoplasmic part
0.41	GO:0098588	bounding membrane of organelle
0.41	GO:0031984	organelle subcompartment
0.39	GO:0031301	integral component of organelle membrane
0.36	GO:0070062	extracellular exosome

0.84

EC:2.8.2.20

GO:0008476

sp|O60706|ABCC9_HUMAN
ATP-binding cassette sub-family C member 9
Search

ABCC9

0.96	ATP-binding cassette transporter sub-family C member 9

0.71	GO:0006813	potassium ion transport
0.60	GO:0007165	signal transduction
0.54	GO:0055085	transmembrane transport
0.51	GO:0051607	defense response to virus
0.43	GO:0042493	response to drug
0.37	GO:0006932	substrate-dependent cell migration, cell contraction
0.36	GO:1903779	regulation of cardiac conduction
0.35	GO:0065009	regulation of molecular function
0.34	GO:0099133	ATP hydrolysis coupled anion transmembrane transport

0.86	GO:0008281	sulfonylurea receptor activity
0.65	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.55	GO:0044325	ion channel binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0005267	potassium channel activity
0.37	GO:0015459	potassium channel regulator activity
0.35	GO:0019905	syntaxin binding
0.34	GO:0008146	sulfotransferase activity

0.60	GO:0008282	inward rectifying potassium channel
0.56	GO:0042383	sarcolemma
0.53	GO:0030017	sarcomere
0.45	GO:0008076	voltage-gated potassium channel complex
0.35	GO:0001669	acrosomal vesicle
0.33	GO:0005739	mitochondrion

0.34

GO:0008146

sp|O60711|LPXN_HUMAN
Leupaxin
Search

LPXN

0.94

Leupaxin

0.72	GO:0007155	cell adhesion
0.71	GO:0050859	negative regulation of B cell receptor signaling pathway
0.67	GO:0033628	regulation of cell adhesion mediated by integrin
0.64	GO:0007162	negative regulation of cell adhesion
0.57	GO:2001141	regulation of RNA biosynthetic process
0.37	GO:0006461	protein complex assembly
0.37	GO:0006351	transcription, DNA-templated
0.37	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.36	GO:0010468	regulation of gene expression
0.36	GO:0007165	signal transduction

0.76	GO:0003712	transcription cofactor activity
0.54	GO:0046872	metal ion binding
0.38	GO:0005515	protein binding

0.85	GO:0002102	podosome
0.82	GO:0005925	focal adhesion
0.62	GO:0016607	nuclear speck
0.55	GO:0005829	cytosol
0.47	GO:0005886	plasma membrane
0.42	GO:0048471	perinuclear region of cytoplasm
0.39	GO:0042995	cell projection

sp|O60716|CTND1_HUMAN
Catenin delta-1
Search

CTNND1

0.93	Catenin (Cadherin-associated protein), delta 1

0.75	GO:0098609	cell-cell adhesion
0.53	GO:0090090	negative regulation of canonical Wnt signaling pathway
0.38	GO:0060690	epithelial cell differentiation involved in salivary gland development
0.38	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation
0.38	GO:0072102	glomerulus morphogenesis
0.37	GO:0010954	positive regulation of protein processing
0.37	GO:0007435	salivary gland morphogenesis
0.37	GO:0030216	keratinocyte differentiation
0.37	GO:0001738	morphogenesis of a polarized epithelium
0.36	GO:0007420	brain development

0.79	GO:0045296	cadherin binding
0.48	GO:0005102	receptor binding
0.37	GO:0019899	enzyme binding
0.36	GO:0019904	protein domain specific binding

0.52	GO:0030496	midbody
0.50	GO:0005911	cell-cell junction
0.46	GO:0005829	cytosol
0.43	GO:0005634	nucleus
0.41	GO:0005886	plasma membrane
0.38	GO:0030027	lamellipodium
0.38	GO:0005912	adherens junction
0.37	GO:0043197	dendritic spine
0.37	GO:0030426	growth cone
0.37	GO:0070062	extracellular exosome

sp|O60721|NCKX1_HUMAN
Sodium/potassium/calcium exchanger 1
Search

SLC24A1

0.84	Sodium/potassium/calcium exchanger 1

0.69	GO:0007601	visual perception
0.68	GO:0035725	sodium ion transmembrane transport
0.64	GO:0006816	calcium ion transport
0.56	GO:0060292	long term synaptic depression
0.54	GO:0060291	long-term synaptic potentiation
0.51	GO:0006874	cellular calcium ion homeostasis
0.43	GO:0007613	memory
0.43	GO:0007612	learning
0.38	GO:0009642	response to light intensity
0.37	GO:0006813	potassium ion transport

0.77	GO:0008273	calcium, potassium:sodium antiporter activity
0.51	GO:0005262	calcium channel activity
0.49	GO:0031402	sodium ion binding
0.48	GO:0030955	potassium ion binding
0.45	GO:0005509	calcium ion binding
0.40	GO:0015293	symporter activity
0.37	GO:0046870	cadmium ion binding
0.36	GO:0005515	protein binding
0.35	GO:0016151	nickel cation binding
0.35	GO:0030145	manganese ion binding

0.44	GO:0005887	integral component of plasma membrane
0.36	GO:0019867	outer membrane

sp|O60725|ICMT_HUMAN
Protein-S-isoprenylcysteine O-methyltransferase
Search

ICMT

0.62	Protein-S-isoprenylcysteine O-methyltransferase

0.82	GO:0006481	C-terminal protein methylation
0.38	GO:0007186	G-protein coupled receptor signaling pathway
0.37	GO:0035264	multicellular organism growth
0.37	GO:0001889	liver development
0.37	GO:0001701	in utero embryonic development
0.36	GO:0008284	positive regulation of cell proliferation
0.36	GO:0046578	regulation of Ras protein signal transduction
0.36	GO:0008104	protein localization
0.35	GO:0046499	S-adenosylmethioninamine metabolic process
0.34	GO:0046498	S-adenosylhomocysteine metabolic process

0.82	GO:0004671	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
0.38	GO:0004930	G-protein coupled receptor activity
0.37	GO:0008140	cAMP response element binding protein binding
0.32	GO:0003676	nucleic acid binding

0.71	GO:0005789	endoplasmic reticulum membrane
0.30	GO:0016021	integral component of membrane

0.82	EC:2.1.1.100	GO:0004671
0.82	KEGG:R04496	GO:0004671

sp|O60729|CC14B_HUMAN
Dual specificity protein phosphatase CDC14B
Search

CDC14B

0.89	Dual specificity protein phosphatase CDC14B

0.75	GO:0035335	peptidyl-tyrosine dephosphorylation
0.47	GO:0051256	mitotic spindle midzone assembly
0.46	GO:0071850	mitotic cell cycle arrest
0.45	GO:0007096	regulation of exit from mitosis
0.44	GO:0060271	cilium assembly
0.43	GO:0072425	signal transduction involved in G2 DNA damage checkpoint
0.41	GO:1904668	positive regulation of ubiquitin protein ligase activity
0.38	GO:0006281	DNA repair
0.36	GO:0008283	cell proliferation
0.35	GO:0051301	cell division

0.79	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.75	GO:0004725	protein tyrosine phosphatase activity
0.43	GO:0004722	protein serine/threonine phosphatase activity
0.37	GO:0005515	protein binding

0.45	GO:0005813	centrosome
0.44	GO:0072686	mitotic spindle
0.44	GO:0000922	spindle pole
0.43	GO:0005730	nucleolus
0.41	GO:0005654	nucleoplasm
0.37	GO:0060091	kinocilium
0.36	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.79

GO:0008138

sp|O60732|MAGC1_HUMAN
Melanoma-associated antigen C1
Search

0.59	GO:0051443	positive regulation of ubiquitin-protein transferase activity
0.54	GO:0000122	negative regulation of transcription by RNA polymerase II
0.52	GO:0044257	cellular protein catabolic process
0.50	GO:0045746	negative regulation of Notch signaling pathway
0.35	GO:0006351	transcription, DNA-templated

0.60

GO:0019899

enzyme binding

0.55	GO:0005829	cytosol
0.55	GO:0031981	nuclear lumen
0.46	GO:0043232	intracellular non-membrane-bounded organelle
0.34	GO:0005886	plasma membrane

sp|O60733|PLPL9_HUMAN
85/88 kDa calcium-independent phospholipase A2
Search

PLA2G6

0.90	Phospholipase A2, group VI (cytosolic, calcium-independent)

0.70	GO:0016042	lipid catabolic process
0.57	GO:0019731	antibacterial humoral response
0.53	GO:0032049	cardiolipin biosynthetic process
0.41	GO:0090238	positive regulation of arachidonic acid secretion
0.41	GO:2000304	positive regulation of ceramide biosynthetic process
0.41	GO:0014832	urinary bladder smooth muscle contraction
0.41	GO:0051967	negative regulation of synaptic transmission, glutamatergic
0.40	GO:0090037	positive regulation of protein kinase C signaling
0.40	GO:1901339	regulation of store-operated calcium channel activity
0.40	GO:0090200	positive regulation of release of cytochrome c from mitochondria

0.50	GO:0016787	hydrolase activity
0.41	GO:0043008	ATP-dependent protein binding
0.39	GO:0005516	calmodulin binding
0.38	GO:0019901	protein kinase binding

0.51	GO:0005815	microtubule organizing center
0.50	GO:0005615	extracellular space
0.48	GO:0005829	cytosol
0.35	GO:0005739	mitochondrion
0.33	GO:0019866	organelle inner membrane
0.30	GO:0016021	integral component of membrane

0.50

GO:0016787

sp|O60739|EIF1B_HUMAN
Eukaryotic translation initiation factor 1b
Search

EIF1B

0.92	Eukaryotic translation initiation factor 1

0.72	GO:0006413	translational initiation
0.47	GO:0006446	regulation of translational initiation
0.45	GO:0009048	dosage compensation by inactivation of X chromosome
0.34	GO:0006886	intracellular protein transport

0.73	GO:0003743	translation initiation factor activity
0.35	GO:0017137	Rab GTPase binding
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0016787	hydrolase activity

0.41	GO:0005634	nucleus
0.37	GO:0005737	cytoplasm
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0016020	membrane

0.32

GO:0016787

sp|O60741|HCN1_HUMAN
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Search

HCN1

0.92	Hyperpolarization activated cyclic nucleotide-gated potassium channel

0.72	GO:0071805	potassium ion transmembrane transport
0.68	GO:0006814	sodium ion transport
0.68	GO:0034765	regulation of ion transmembrane transport
0.60	GO:0071320	cellular response to cAMP
0.57	GO:0046549	retinal cone cell development
0.56	GO:0042391	regulation of membrane potential
0.56	GO:0051289	protein homotetramerization
0.56	GO:0045176	apical protein localization
0.55	GO:0002027	regulation of heart rate
0.46	GO:0035677	posterior lateral line neuromast hair cell development

0.79	GO:0030552	cAMP binding
0.76	GO:0005249	voltage-gated potassium channel activity
0.61	GO:0005222	intracellular cAMP activated cation channel activity
0.58	GO:0005248	voltage-gated sodium channel activity
0.51	GO:0042802	identical protein binding
0.35	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
0.35	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.35	GO:0008022	protein C-terminus binding
0.34	GO:0032403	protein complex binding
0.32	GO:0005524	ATP binding

0.63	GO:0098855	HCN channel complex
0.52	GO:0030425	dendrite
0.52	GO:0030424	axon
0.39	GO:0048471	perinuclear region of cytoplasm
0.35	GO:0032589	neuron projection membrane
0.35	GO:0043679	axon terminus
0.35	GO:0016323	basolateral plasma membrane
0.35	GO:0043025	neuronal cell body
0.34	GO:0009986	cell surface

sp|O60749|SNX2_HUMAN
Sorting nexin-2
Search

SNX2

0.87	Sorting nexin-2

0.70	GO:0006897	endocytosis
0.68	GO:0006886	intracellular protein transport
0.59	GO:0072673	lamellipodium morphogenesis
0.55	GO:0042147	retrograde transport, endosome to Golgi
0.49	GO:0051259	protein oligomerization
0.45	GO:0016050	vesicle organization
0.44	GO:0048193	Golgi vesicle transport

0.75	GO:0035091	phosphatidylinositol binding
0.59	GO:1990460	leptin receptor binding
0.57	GO:1990459	transferrin receptor binding
0.56	GO:0005158	insulin receptor binding
0.56	GO:0005154	epidermal growth factor receptor binding
0.53	GO:0045296	cadherin binding
0.50	GO:0042803	protein homodimerization activity
0.50	GO:0046982	protein heterodimerization activity

0.81	GO:0030904	retromer complex
0.54	GO:0010008	endosome membrane
0.52	GO:0005764	lysosome
0.49	GO:0005829	cytosol
0.44	GO:0019898	extrinsic component of membrane
0.40	GO:0030027	lamellipodium
0.40	GO:0005769	early endosome
0.36	GO:0070062	extracellular exosome
0.30	GO:0031224	intrinsic component of membrane

sp|O60755|GALR3_HUMAN
Galanin receptor type 3
Search

GALR3

0.95	Galanin receptor type 3

0.69	GO:0007186	G-protein coupled receptor signaling pathway
0.64	GO:0007194	negative regulation of adenylate cyclase activity
0.53	GO:0045944	positive regulation of transcription by RNA polymerase II
0.50	GO:1902606	regulation of large conductance calcium-activated potassium channel activity
0.49	GO:0007204	positive regulation of cytosolic calcium ion concentration
0.48	GO:1901018	positive regulation of potassium ion transmembrane transporter activity
0.47	GO:2001259	positive regulation of cation channel activity
0.45	GO:0031175	neuron projection development
0.38	GO:0007631	feeding behavior
0.38	GO:0019933	cAMP-mediated signaling

0.70	GO:0004930	G-protein coupled receptor activity
0.61	GO:0001653	peptide receptor activity
0.59	GO:0017046	peptide hormone binding
0.38	GO:0042923	neuropeptide binding
0.34	GO:0005230	extracellular ligand-gated ion channel activity
0.33	GO:0005515	protein binding

0.52	GO:0097730	non-motile cilium
0.43	GO:0005887	integral component of plasma membrane
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0019866	organelle inner membrane

sp|O60756|BCE1_HUMAN
Putative protein BCE-1
Search

0.10	Putative protein BCE-1

sp|O60759|CYTIP_HUMAN
Cytohesin-interacting protein
Search

CYTIP

0.97	Cytohesin-interacting protein isoform A

0.73	GO:0030155	regulation of cell adhesion
0.41	GO:0007165	signal transduction
0.36	GO:0008104	protein localization
0.34	GO:0046907	intracellular transport
0.34	GO:0070727	cellular macromolecule localization
0.34	GO:0042886	amide transport
0.33	GO:0071702	organic substance transport

0.40	GO:0030306	ADP-ribosylation factor binding
0.39	GO:0030165	PDZ domain binding
0.37	GO:0042802	identical protein binding

0.73	GO:0005938	cell cortex
0.66	GO:0005654	nucleoplasm
0.65	GO:0005829	cytosol
0.45	GO:0005769	early endosome
0.39	GO:0005886	plasma membrane
0.37	GO:0048471	perinuclear region of cytoplasm
0.36	GO:0098794	postsynapse
0.36	GO:0030054	cell junction
0.36	GO:0005641	nuclear envelope lumen
0.30	GO:0016021	integral component of membrane

sp|O60760|HPGDS_HUMAN
Hematopoietic prostaglandin D synthase
Search

HPGDS

0.97	Glutathione-requiring prostaglandin D synthase

0.85	GO:0006692	prostanoid metabolic process
0.84	GO:2000255	negative regulation of male germ cell proliferation
0.50	GO:0046456	icosanoid biosynthetic process
0.49	GO:0006636	unsaturated fatty acid biosynthetic process
0.43	GO:1901685	glutathione derivative metabolic process
0.41	GO:0019369	arachidonic acid metabolic process
0.40	GO:0007626	locomotory behavior
0.37	GO:0044272	sulfur compound biosynthetic process
0.36	GO:0007165	signal transduction
0.35	GO:1901566	organonitrogen compound biosynthetic process

0.88	GO:0004667	prostaglandin-D synthase activity
0.75	GO:0042803	protein homodimerization activity
0.70	GO:0005509	calcium ion binding
0.64	GO:0000287	magnesium ion binding
0.47	GO:0004364	glutathione transferase activity

0.38

GO:0005829

cytosol

0.88	EC:5.3.99.2	GO:0004667
0.88	KEGG:R02266	GO:0004667

sp|O60762|DPM1_HUMAN
Dolichol-phosphate mannosyltransferase subunit 1
Search

DPM1

0.52	Dolichol-phosphate mannosyltransferase dolichol-phosphate mannose synthase dolichyl-phosphate beta-d-mannosyltransferase mannose-p-dolichol synthase mpd synthase dpm synthase

0.45	GO:0097502	mannosylation
0.44	GO:0061061	muscle structure development
0.43	GO:0006506	GPI anchor biosynthetic process
0.43	GO:0006493	protein O-linked glycosylation
0.42	GO:0019348	dolichol metabolic process
0.36	GO:0019673	GDP-mannose metabolic process
0.36	GO:0018279	protein N-linked glycosylation via asparagine
0.33	GO:0051260	protein homooligomerization
0.33	GO:0071805	potassium ion transmembrane transport

0.61	GO:0016757	transferase activity, transferring glycosyl groups
0.37	GO:0005537	mannose binding
0.37	GO:0043178	alcohol binding
0.34	GO:0005515	protein binding
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0005249	voltage-gated potassium channel activity
0.32	GO:0003677	DNA binding

0.41	GO:0005783	endoplasmic reticulum
0.41	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
0.40	GO:0033185	dolichol-phosphate-mannose synthase complex
0.40	GO:0031984	organelle subcompartment
0.35	GO:0005634	nucleus
0.33	GO:0008076	voltage-gated potassium channel complex

0.61

GO:0016757

sp|O60763|USO1_HUMAN
General vesicular transport factor p115
Search

USO1

0.92	USO1 vesicle transport factor

0.85	GO:0048280	vesicle fusion with Golgi apparatus
0.69	GO:0006886	intracellular protein transport
0.56	GO:0007030	Golgi organization
0.52	GO:0048211	Golgi vesicle docking
0.51	GO:0045056	transcytosis
0.47	GO:0006888	ER to Golgi vesicle-mediated transport

0.68	GO:0008565	protein transporter activity
0.58	GO:0045296	cadherin binding

0.74	GO:0000139	Golgi membrane
0.59	GO:0001650	fibrillar center
0.55	GO:0048471	perinuclear region of cytoplasm
0.49	GO:0005829	cytosol
0.48	GO:0012507	ER to Golgi transport vesicle membrane
0.48	GO:0005795	Golgi stack
0.44	GO:0005783	endoplasmic reticulum
0.36	GO:0070382	exocytic vesicle
0.30	GO:0031224	intrinsic component of membrane

sp|O60765|Z354A_HUMAN
Zinc finger protein 354A
Search

0.93	Epididymis luminal protein 104

0.55	GO:1903506	regulation of nucleic acid-templated transcription
0.55	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.43	GO:1902679	negative regulation of RNA biosynthetic process
0.40	GO:0007576	nucleolar fragmentation
0.39	GO:0051593	response to folic acid
0.38	GO:0006351	transcription, DNA-templated
0.37	GO:0001666	response to hypoxia
0.37	GO:0001822	kidney development
0.34	GO:0007605	sensory perception of sound

0.52	GO:0046872	metal ion binding
0.51	GO:0003676	nucleic acid binding
0.44	GO:0003700	DNA binding transcription factor activity
0.43	GO:0003682	chromatin binding
0.33	GO:0003735	structural constituent of ribosome
0.32	GO:0005515	protein binding

0.44	GO:0005622	intracellular
0.40	GO:0031974	membrane-enclosed lumen
0.39	GO:0043227	membrane-bounded organelle
0.38	GO:0043228	non-membrane-bounded organelle
0.37	GO:0044422	organelle part
0.33	GO:1990904	ribonucleoprotein complex

sp|O60774|FMO6_HUMAN
Putative dimethylaniline monooxygenase [N-oxide-forming] 6
Search

FMO3

0.61	Flavin-containing monooxygenase

0.52	GO:0055114	oxidation-reduction process
0.41	GO:0042737	drug catabolic process
0.40	GO:0006739	NADP metabolic process
0.40	GO:0009404	toxin metabolic process
0.38	GO:0072592	oxygen metabolic process
0.37	GO:0006805	xenobiotic metabolic process
0.36	GO:0006082	organic acid metabolic process

0.78	GO:0004499	N,N-dimethylaniline monooxygenase activity
0.69	GO:0050661	NADP binding
0.65	GO:0050660	flavin adenine dinucleotide binding
0.45	GO:0034899	trimethylamine monooxygenase activity
0.34	GO:0016597	amino acid binding
0.33	GO:0005515	protein binding

0.41	GO:0005789	endoplasmic reticulum membrane
0.38	GO:0031090	organelle membrane
0.30	GO:0031224	intrinsic component of membrane

0.78	EC:1.14.13.8	GO:0004499
0.45	KEGG:R05623	GO:0034899

sp|O60779|S19A2_HUMAN
Thiamine transporter 1
Search

SLC19A2

0.93	High affinity thiamine transport protein 1

0.81	GO:0035461	vitamin transmembrane transport
0.45	GO:0015888	thiamine transport
0.44	GO:0072531	pyrimidine-containing compound transmembrane transport
0.42	GO:0006855	drug transmembrane transport
0.39	GO:0015884	folic acid transport
0.36	GO:0042723	thiamine-containing compound metabolic process

0.76	GO:0090482	vitamin transmembrane transporter activity
0.45	GO:1901474	azole transmembrane transporter activity
0.43	GO:1901682	sulfur compound transmembrane transporter activity
0.42	GO:0015238	drug transmembrane transporter activity
0.38	GO:0072349	modified amino acid transmembrane transporter activity
0.37	GO:0005310	dicarboxylic acid transmembrane transporter activity
0.36	GO:0042887	amide transmembrane transporter activity
0.35	GO:0005515	protein binding

0.37	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O60783|RT14_HUMAN
28S ribosomal protein S14, mitochondrial
Search

MRPS14

0.95	Mitochondrial ribosomal protein S14

0.60	GO:0043043	peptide biosynthetic process
0.56	GO:0044267	cellular protein metabolic process
0.54	GO:0010467	gene expression
0.53	GO:0009059	macromolecule biosynthetic process
0.34	GO:0043624	cellular protein complex disassembly

0.64	GO:0003735	structural constituent of ribosome
0.35	GO:0003723	RNA binding
0.33	GO:0005515	protein binding
0.33	GO:0016746	transferase activity, transferring acyl groups
0.32	GO:0004872	receptor activity
0.32	GO:0016787	hydrolase activity

0.61	GO:0005840	ribosome
0.53	GO:0005759	mitochondrial matrix
0.34	GO:0031966	mitochondrial membrane
0.34	GO:0019866	organelle inner membrane
0.30	GO:0031224	intrinsic component of membrane

0.33

GO:0016746

sp|O60784|TOM1_HUMAN
Target of Myb protein 1
Search

TOM1

0.91	Target of Myb protein 1

0.67	GO:0006886	intracellular protein transport
0.41	GO:0045839	negative regulation of mitotic nuclear division
0.37	GO:0007165	signal transduction
0.36	GO:0043312	neutrophil degranulation
0.35	GO:0016197	endosomal transport
0.34	GO:0006897	endocytosis

0.55	GO:0030276	clathrin binding
0.40	GO:0019901	protein kinase binding

0.53	GO:0005769	early endosome
0.48	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.36	GO:0035579	specific granule membrane
0.36	GO:0035577	azurophil granule membrane
0.33	GO:0005886	plasma membrane

sp|O60806|TBX19_HUMAN
T-box transcription factor TBX19
Search

TBX19

0.97	T-box-containing protein TBXT (Fragment)

0.58	GO:0097659	nucleic acid-templated transcription
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.54	GO:0010467	gene expression
0.53	GO:0034645	cellular macromolecule biosynthetic process

0.61	GO:0003700	DNA binding transcription factor activity
0.55	GO:0003677	DNA binding

0.61

GO:0005634

nucleus

sp|O60809|PRA10_HUMAN
PRAME family member 10
Search

0.93	PRAME family member 1

0.79	GO:0045596	negative regulation of cell differentiation
0.79	GO:0008284	positive regulation of cell proliferation
0.78	GO:0043066	negative regulation of apoptotic process
0.72	GO:0045892	negative regulation of transcription, DNA-templated

sp|O60810|PRAM4_HUMAN
PRAME family member 4
Search

0.88	PRAME family member 4

0.79	GO:0045596	negative regulation of cell differentiation
0.79	GO:0008284	positive regulation of cell proliferation
0.78	GO:0043066	negative regulation of apoptotic process
0.72	GO:0045892	negative regulation of transcription, DNA-templated

sp|O60811|PRAM2_HUMAN
PRAME family member 2
Search

0.93	PRAME family member 2

0.79	GO:0045596	negative regulation of cell differentiation
0.79	GO:0008284	positive regulation of cell proliferation
0.78	GO:0043066	negative regulation of apoptotic process
0.72	GO:0045892	negative regulation of transcription, DNA-templated

sp|O60812|HNRC1_HUMAN
Heterogeneous nuclear ribonucleoprotein C-like 1
Search

HNRNPC

0.95	Heterogeneous nuclear ribonucleoprotein C

0.44	GO:0070935	3'-UTR-mediated mRNA stabilization
0.44	GO:0032211	negative regulation of telomere maintenance via telomerase
0.43	GO:0000398	mRNA splicing, via spliceosome
0.39	GO:0001649	osteoblast differentiation
0.38	GO:0043044	ATP-dependent chromatin remodeling
0.38	GO:0090367	negative regulation of mRNA modification
0.35	GO:0043086	negative regulation of catalytic activity
0.34	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
0.33	GO:0007186	G-protein coupled receptor signaling pathway

0.59	GO:0003723	RNA binding
0.41	GO:0042802	identical protein binding
0.39	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
0.39	GO:0031492	nucleosomal DNA binding
0.38	GO:1990827	deaminase binding
0.38	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
0.35	GO:0019904	protein domain specific binding
0.35	GO:0004857	enzyme inhibitor activity
0.35	GO:0043021	ribonucleoprotein complex binding
0.34	GO:0004984	olfactory receptor activity

0.65	GO:0019013	viral nucleocapsid
0.58	GO:0030529	intracellular ribonucleoprotein complex
0.44	GO:0005634	nucleus
0.41	GO:0043233	organelle lumen
0.41	GO:0015629	actin cytoskeleton
0.39	GO:0005829	cytosol
0.39	GO:0044446	intracellular organelle part
0.39	GO:0005576	extracellular region
0.38	GO:1902494	catalytic complex
0.37	GO:0043234	protein complex

sp|O60813|PRA11_HUMAN
PRAME family member 11
Search

0.88	PRAME family member 9

0.79	GO:0045596	negative regulation of cell differentiation
0.79	GO:0008284	positive regulation of cell proliferation
0.78	GO:0043066	negative regulation of apoptotic process
0.72	GO:0045892	negative regulation of transcription, DNA-templated

sp|O60814|H2B1K_HUMAN
Histone H2B type 1-K
Search

HIST1H2BK

0.95	Histone H2B type 1-K

0.49	GO:0002227	innate immune response in mucosa
0.49	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
0.48	GO:0019731	antibacterial humoral response
0.48	GO:0006334	nucleosome assembly
0.47	GO:0050830	defense response to Gram-positive bacterium
0.45	GO:0050829	defense response to Gram-negative bacterium
0.44	GO:0031640	killing of cells of other organism
0.43	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
0.35	GO:0016567	protein ubiquitination
0.33	GO:0006352	DNA-templated transcription, initiation

0.74	GO:0046982	protein heterodimerization activity
0.55	GO:0003677	DNA binding
0.42	GO:0001530	lipopolysaccharide binding
0.34	GO:0042802	identical protein binding

0.74	GO:0000786	nucleosome
0.61	GO:0005634	nucleus
0.47	GO:0005829	cytosol
0.46	GO:0031974	membrane-enclosed lumen
0.44	GO:0005615	extracellular space
0.36	GO:0005886	plasma membrane
0.34	GO:1903561	extracellular vesicle
0.34	GO:0000781	chromosome, telomeric region
0.30	GO:0031224	intrinsic component of membrane

sp|O60825|F262_HUMAN
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Search

PFKFB2

0.93	6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 transcript variant 3

0.81	GO:0006003	fructose 2,6-bisphosphate metabolic process
0.80	GO:0006000	fructose metabolic process
0.72	GO:0046835	carbohydrate phosphorylation
0.50	GO:0006757	ATP generation from ADP
0.49	GO:0006090	pyruvate metabolic process
0.49	GO:0016052	carbohydrate catabolic process
0.48	GO:0046496	nicotinamide nucleotide metabolic process
0.40	GO:0016311	dephosphorylation
0.39	GO:0033133	positive regulation of glucokinase activity
0.38	GO:0032024	positive regulation of insulin secretion

0.82	GO:0003873	6-phosphofructo-2-kinase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0019901	protein kinase binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.46	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity

0.49	GO:0005654	nucleoplasm
0.34	GO:0005829	cytosol

0.82	EC:2.7.1.105	GO:0003873
0.82	KEGG:R02732	GO:0003873

sp|O60826|CCD22_HUMAN
Coiled-coil domain-containing protein 22
Search

CCDC22

0.97	Coiled-coil domain-containing protein 22

0.86	GO:0007253	cytoplasmic sequestering of NF-kappaB
0.86	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.80	GO:0006893	Golgi to plasma membrane transport
0.80	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.77	GO:0006878	cellular copper ion homeostasis
0.44	GO:0015031	protein transport
0.41	GO:0097006	regulation of plasma lipoprotein particle levels
0.40	GO:0043687	post-translational protein modification
0.40	GO:0042632	cholesterol homeostasis
0.39	GO:0016567	protein ubiquitination

0.86

GO:0097602

cullin family protein binding

0.45	GO:0005768	endosome
0.38	GO:0005654	nucleoplasm
0.38	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O60828|PQBP1_HUMAN
Polyglutamine-binding protein 1
Search

PQBP1

0.97	Polyglutamine-binding protein 1

0.86	GO:0000380	alternative mRNA splicing, via spliceosome
0.85	GO:0071360	cellular response to exogenous dsRNA
0.85	GO:0002230	positive regulation of defense response to virus by host
0.84	GO:0032481	positive regulation of type I interferon production
0.83	GO:0048814	regulation of dendrite morphogenesis
0.79	GO:0002218	activation of innate immune response
0.78	GO:0031175	neuron projection development
0.77	GO:0043484	regulation of RNA splicing
0.75	GO:0051607	defense response to virus
0.66	GO:0045087	innate immune response

0.70	GO:0003690	double-stranded DNA binding
0.69	GO:0043021	ribonucleoprotein complex binding
0.46	GO:0008022	protein C-terminus binding
0.45	GO:0003713	transcription coactivator activity

0.86	GO:0071598	neuronal ribonucleoprotein granule
0.80	GO:0016607	nuclear speck
0.79	GO:0010494	cytoplasmic stress granule
0.63	GO:0005829	cytosol
0.47	GO:0097546	ciliary base
0.44	GO:0005813	centrosome

sp|O60829|PAGE4_HUMAN
P antigen family member 4
Search

0.97	P antigen family, member 4 (Prostate associated)

0.53

GO:0005515

protein binding

sp|O60830|TI17B_HUMAN
Mitochondrial import inner membrane translocase subunit Tim17-B
Search

TIMM17B

0.85	Mitochondrial import inner membrane translocase subunit Tim17-B

0.64	GO:0071806	protein transmembrane transport
0.63	GO:0006886	intracellular protein transport
0.48	GO:1990542	mitochondrial transmembrane transport
0.47	GO:0072655	establishment of protein localization to mitochondrion
0.46	GO:0007005	mitochondrion organization
0.46	GO:0017038	protein import
0.39	GO:0010954	positive regulation of protein processing
0.33	GO:0008643	carbohydrate transport
0.33	GO:1902600	hydrogen ion transmembrane transport

0.68	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
0.34	GO:0005351	sugar:proton symporter activity
0.34	GO:0005515	protein binding

0.74	GO:0005744	mitochondrial inner membrane presequence translocase complex
0.57	GO:0031305	integral component of mitochondrial inner membrane
0.43	GO:0005654	nucleoplasm
0.34	GO:0000139	Golgi membrane

sp|O60831|PRAF2_HUMAN
PRA1 family protein 2
Search

sp|O60832|DKC1_HUMAN
H/ACA ribonucleoprotein complex subunit 4
Search

DKC1

0.72	Dyskerin pseudouridine synthase 1

0.72	GO:0001522	pseudouridine synthesis
0.67	GO:0090669	telomerase RNA stabilization
0.66	GO:1904851	positive regulation of establishment of protein localization to telomere
0.66	GO:0033979	box H/ACA snoRNA metabolic process
0.65	GO:1904874	positive regulation of telomerase RNA localization to Cajal body
0.64	GO:0051973	positive regulation of telomerase activity
0.64	GO:0007004	telomere maintenance via telomerase
0.63	GO:0006396	RNA processing
0.61	GO:0032212	positive regulation of telomere maintenance via telomerase
0.55	GO:0016072	rRNA metabolic process

0.72	GO:0009982	pseudouridine synthase activity
0.65	GO:0034513	box H/ACA snoRNA binding
0.65	GO:0070034	telomerase RNA binding
0.63	GO:0003720	telomerase activity

0.66	GO:0090661	box H/ACA telomerase RNP complex
0.64	GO:0031429	box H/ACA snoRNP complex
0.61	GO:0001650	fibrillar center
0.60	GO:0015030	Cajal body
0.40	GO:0019013	viral nucleocapsid

0.72

EC:5.4.99.12

GO:0009982

sp|O60840|CAC1F_HUMAN
Voltage-dependent L-type calcium channel subunit alpha-1F
Search

CACNA1F

0.67	Voltage-dependent L-type calcium channel subunit alpha

0.77	GO:0034765	regulation of ion transmembrane transport
0.77	GO:0070588	calcium ion transmembrane transport
0.73	GO:0043029	T cell homeostasis
0.73	GO:0050856	regulation of T cell receptor signaling pathway
0.66	GO:0007601	visual perception
0.59	GO:0050962	detection of light stimulus involved in sensory perception
0.55	GO:0009584	detection of visible light
0.52	GO:0086010	membrane depolarization during action potential
0.45	GO:0051924	regulation of calcium ion transport
0.45	GO:0022898	regulation of transmembrane transporter activity

0.82	GO:0005245	voltage-gated calcium channel activity
0.42	GO:0051393	alpha-actinin binding
0.41	GO:0030506	ankyrin binding
0.35	GO:0046872	metal ion binding

0.81	GO:0005891	voltage-gated calcium channel complex
0.42	GO:0043025	neuronal cell body
0.42	GO:0001750	photoreceptor outer segment
0.41	GO:0030315	T-tubule
0.40	GO:0030018	Z disc
0.39	GO:0045202	synapse
0.38	GO:0009925	basal plasma membrane
0.33	GO:0005887	integral component of plasma membrane

sp|O60841|IF2P_HUMAN
Eukaryotic translation initiation factor 5B
Search

EIF5B

0.86	LOW QUALITY PROTEIN: eukaryotic translation initiation factor 5B

0.66	GO:0006413	translational initiation
0.53	GO:0006446	regulation of translational initiation

0.67	GO:0003743	translation initiation factor activity
0.65	GO:0003924	GTPase activity
0.64	GO:0032550	purine ribonucleoside binding
0.64	GO:0019001	guanyl nucleotide binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0005515	protein binding
0.35	GO:0046872	metal ion binding

0.39	GO:0005737	cytoplasm
0.34	GO:0005634	nucleus

sp|O60844|ZG16_HUMAN
Zymogen granule membrane protein 16
Search

ZG16

0.97	Zymogen granule membrane protein 16

0.40

GO:0015031

protein transport

0.70	GO:0030246	carbohydrate binding
0.36	GO:0005515	protein binding

0.86	GO:0042589	zymogen granule membrane
0.77	GO:0005796	Golgi lumen
0.64	GO:0031012	extracellular matrix
0.47	GO:0060205	cytoplasmic vesicle lumen

sp|O60858|TRI13_HUMAN
E3 ubiquitin-protein ligase TRIM13
Search

TRIM13

0.97	Tripartite motif-containing protein 13

0.61	GO:1902187	negative regulation of viral release from host cell
0.61	GO:0032897	negative regulation of viral transcription
0.60	GO:0010332	response to gamma radiation
0.59	GO:0051865	protein autoubiquitination
0.59	GO:0016239	positive regulation of macroautophagy
0.58	GO:0051092	positive regulation of NF-kappaB transcription factor activity
0.58	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
0.57	GO:0030433	ubiquitin-dependent ERAD pathway
0.56	GO:0045087	innate immune response
0.55	GO:0010942	positive regulation of cell death

0.63	GO:0008270	zinc ion binding
0.53	GO:0004842	ubiquitin-protein transferase activity
0.46	GO:0016874	ligase activity
0.37	GO:0061659	ubiquitin-like protein ligase activity
0.35	GO:0004871	signal transducer activity
0.34	GO:0005515	protein binding

0.60	GO:0097038	perinuclear endoplasmic reticulum
0.52	GO:0005789	endoplasmic reticulum membrane
0.39	GO:0005929	cilium
0.37	GO:0030992	intraciliary transport particle B
0.36	GO:0044322	endoplasmic reticulum quality control compartment
0.36	GO:0005813	centrosome
0.33	GO:0005634	nucleus
0.32	GO:0005764	lysosome
0.32	GO:0005874	microtubule
0.30	GO:0016021	integral component of membrane

0.46	EC:6	GO:0016874
0.53	KEGG:R03876	GO:0004842

sp|O60861|GAS7_HUMAN
Growth arrest-specific protein 7
Search

GAS7

0.97	Growth arrest-specific protein 7

0.69	GO:0007399	nervous system development
0.67	GO:0030154	cell differentiation
0.59	GO:0030041	actin filament polymerization
0.59	GO:0051017	actin filament bundle assembly
0.57	GO:0043009	chordate embryonic development
0.57	GO:0120039	plasma membrane bounded cell projection morphogenesis
0.55	GO:0120036	plasma membrane bounded cell projection organization
0.53	GO:0007050	cell cycle arrest
0.52	GO:0008360	regulation of cell shape
0.42	GO:1903506	regulation of nucleic acid-templated transcription

0.56	GO:0051015	actin filament binding
0.46	GO:0042302	structural constituent of cuticle
0.43	GO:0003700	DNA binding transcription factor activity

0.59	GO:0001726	ruffle
0.59	GO:0005884	actin filament
0.43	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

sp|O60869|EDF1_HUMAN
Endothelial differentiation-related factor 1
Search

EDF1

0.96	Endothelial differentiation-related factor 1 isoform alpha

0.54	GO:0043388	positive regulation of DNA binding
0.42	GO:2001141	regulation of RNA biosynthetic process
0.37	GO:0030154	cell differentiation
0.37	GO:0007275	multicellular organism development
0.36	GO:0006351	transcription, DNA-templated
0.36	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.36	GO:0010468	regulation of gene expression
0.35	GO:0003158	endothelium development
0.34	GO:0019216	regulation of lipid metabolic process
0.34	GO:0051254	positive regulation of RNA metabolic process

0.63	GO:0043565	sequence-specific DNA binding
0.51	GO:0003713	transcription coactivator activity
0.38	GO:0005516	calmodulin binding
0.36	GO:0004402	histone acetyltransferase activity
0.34	GO:0008168	methyltransferase activity
0.34	GO:0003700	DNA binding transcription factor activity
0.34	GO:0003723	RNA binding

0.51	GO:0005669	transcription factor TFIID complex
0.48	GO:0005730	nucleolus
0.46	GO:0005829	cytosol
0.36	GO:0070062	extracellular exosome

0.36

GO:0004402

sp|O60870|KIN17_HUMAN
DNA/RNA-binding protein KIN17
Search

KIN

0.93	DNA/RNA-binding protein KIN17 isoform A

0.64	GO:0006260	DNA replication
0.63	GO:0006974	cellular response to DNA damage stimulus
0.40	GO:0006397	mRNA processing
0.39	GO:0006310	DNA recombination
0.38	GO:0008213	protein alkylation
0.37	GO:0000413	protein peptidyl-prolyl isomerization
0.37	GO:0043414	macromolecule methylation
0.36	GO:0016032	viral process

0.70	GO:0003690	double-stranded DNA binding
0.57	GO:0003723	RNA binding
0.37	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
0.36	GO:0005515	protein binding
0.36	GO:0046872	metal ion binding

0.80	GO:0016363	nuclear matrix
0.57	GO:0043234	protein complex
0.37	GO:0005654	nucleoplasm
0.35	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.37

GO:0003755

sp|O60879|DIAP2_HUMAN
Protein diaphanous homolog 2
Search

DIAPH2

0.94	Diaphanous

0.78	GO:0007292	female gamete generation
0.74	GO:0030036	actin cytoskeleton organization
0.72	GO:0097435	supramolecular fiber organization
0.43	GO:0055113	epiboly involved in gastrulation with mouth forming second
0.42	GO:0060027	convergent extension involved in gastrulation
0.42	GO:0042074	cell migration involved in gastrulation
0.42	GO:0040001	establishment of mitotic spindle localization
0.40	GO:0051258	protein polymerization
0.40	GO:0051056	regulation of small GTPase mediated signal transduction
0.36	GO:0007281	germ cell development

0.76	GO:0017048	Rho GTPase binding
0.73	GO:0003779	actin binding
0.36	GO:0005102	receptor binding
0.35	GO:0030545	receptor regulator activity
0.34	GO:0045296	cadherin binding

0.48	GO:0005730	nucleolus
0.47	GO:0005783	endoplasmic reticulum
0.36	GO:0005769	early endosome
0.35	GO:0005829	cytosol
0.34	GO:0005576	extracellular region
0.30	GO:0031224	intrinsic component of membrane

sp|O60880|SH21A_HUMAN
SH2 domain-containing protein 1A
Search

SH2D1A

0.97	SH2 domain containing 1A duplicate b

0.85	GO:0006968	cellular defense response
0.78	GO:0002250	adaptive immune response
0.75	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
0.75	GO:0007267	cell-cell signaling
0.74	GO:0045087	innate immune response
0.73	GO:0009967	positive regulation of signal transduction
0.69	GO:0006959	humoral immune response

0.82

GO:0005070

SH3/SH2 adaptor activity

0.49

GO:0005737

cytoplasm

sp|O60882|MMP20_HUMAN
Matrix metalloproteinase-20
Search

MMP20

0.70	Matrix metalloproteinase

0.62	GO:0022617	extracellular matrix disassembly
0.61	GO:0006508	proteolysis
0.61	GO:0097186	amelogenesis
0.53	GO:0030574	collagen catabolic process
0.50	GO:0030163	protein catabolic process
0.43	GO:0001503	ossification
0.41	GO:0050900	leukocyte migration
0.40	GO:0003417	growth plate cartilage development
0.39	GO:0031214	biomineral tissue development
0.39	GO:0031290	retinal ganglion cell axon guidance

0.70	GO:0004222	metalloendopeptidase activity
0.63	GO:0008270	zinc ion binding
0.40	GO:0005518	collagen binding
0.38	GO:0005509	calcium ion binding
0.36	GO:0004252	serine-type endopeptidase activity
0.34	GO:0001047	core promoter binding
0.33	GO:0008201	heparin binding
0.33	GO:0042802	identical protein binding
0.33	GO:0043565	sequence-specific DNA binding

0.74	GO:0031012	extracellular matrix
0.37	GO:0005615	extracellular space
0.37	GO:0005581	collagen trimer
0.34	GO:1903561	extracellular vesicle
0.33	GO:0009986	cell surface
0.32	GO:0005634	nucleus
0.32	GO:0005886	plasma membrane
0.32	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

0.70

GO:0004222

sp|O60883|ETBR2_HUMAN
Prosaposin receptor GPR37L1
Search

GPR37L1

0.94	Endothelin B receptor-like protein 2

0.71	GO:0007186	G-protein coupled receptor signaling pathway
0.47	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation
0.47	GO:0048712	negative regulation of astrocyte differentiation
0.47	GO:1901032	negative regulation of response to reactive oxygen species
0.47	GO:2001039	negative regulation of cellular response to drug
0.47	GO:1903205	regulation of hydrogen peroxide-induced cell death
0.46	GO:0045879	negative regulation of smoothened signaling pathway
0.46	GO:1903202	negative regulation of oxidative stress-induced cell death
0.45	GO:0045665	negative regulation of neuron differentiation
0.44	GO:0043410	positive regulation of MAPK cascade

0.72	GO:0004930	G-protein coupled receptor activity
0.44	GO:0042277	peptide binding
0.44	GO:0001653	peptide receptor activity

0.44	GO:0043235	receptor complex
0.37	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O60884|DNJA2_HUMAN
DnaJ homolog subfamily A member 2
Search

DNAJA2

0.90	DnaJ like protein subfamily A member 2

0.67	GO:0006457	protein folding
0.65	GO:0009408	response to heat
0.53	GO:0032781	positive regulation of ATPase activity
0.36	GO:0018885	carbon tetrachloride metabolic process
0.35	GO:0008284	positive regulation of cell proliferation

0.75	GO:0031072	heat shock protein binding
0.70	GO:0051082	unfolded protein binding
0.54	GO:0001671	ATPase activator activity
0.52	GO:0046872	metal ion binding
0.52	GO:0051087	chaperone binding
0.49	GO:0032559	adenyl ribonucleotide binding
0.48	GO:0008144	drug binding
0.48	GO:0035639	purine ribonucleoside triphosphate binding

0.49	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.33	GO:0005634	nucleus
0.30	GO:0031224	intrinsic component of membrane

sp|O60885|BRD4_HUMAN
Bromodomain-containing protein 4
Search

BRD4

0.86	Bromodomain-containing protein 4

0.81	GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain
0.80	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
0.79	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
0.77	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.75	GO:0050727	regulation of inflammatory response
0.75	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
0.58	GO:0002574	thrombocyte differentiation
0.37	GO:0016569	covalent chromatin modification
0.36	GO:0001833	inner cell mass cell proliferation
0.36	GO:2000002	negative regulation of DNA damage checkpoint

0.79	GO:0000993	RNA polymerase II core binding
0.79	GO:0002039	p53 binding
0.79	GO:0042393	histone binding
0.79	GO:0140033	acetylation-dependent protein binding
0.76	GO:0003682	chromatin binding
0.42	GO:0017057	6-phosphogluconolactonase activity
0.36	GO:0034211	GTP-dependent protein kinase activity
0.36	GO:0050815	phosphoserine residue binding
0.35	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
0.35	GO:0008022	protein C-terminus binding

0.75	GO:0000793	condensed chromosome
0.68	GO:0000228	nuclear chromosome
0.65	GO:0005654	nucleoplasm
0.63	GO:0005829	cytosol
0.35	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex
0.35	GO:0032806	carboxy-terminal domain protein kinase complex
0.34	GO:0055029	nuclear DNA-directed RNA polymerase complex
0.34	GO:0005730	nucleolus
0.34	GO:0000785	chromatin
0.30	GO:0031224	intrinsic component of membrane

0.42	EC:3.1.1.31	GO:0017057
0.42	KEGG:R02035	GO:0017057

sp|O60888|CUTA_HUMAN
Protein CutA
Search

CUTA

0.97	CutA divalent cation tolerance homolog

0.77	GO:0010038	response to metal ion
0.46	GO:0008104	protein localization
0.36	GO:0006480	N-terminal protein amino acid methylation
0.35	GO:0019915	lipid storage
0.35	GO:0006986	response to unfolded protein
0.35	GO:0051260	protein homooligomerization
0.33	GO:0046907	intracellular transport
0.33	GO:0070727	cellular macromolecule localization
0.33	GO:0042886	amide transport
0.33	GO:0071702	organic substance transport

0.48	GO:0019899	enzyme binding
0.43	GO:0005507	copper ion binding
0.34	GO:0008168	methyltransferase activity
0.33	GO:0004140	dephospho-CoA kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.31	GO:0008144	drug binding
0.31	GO:0035639	purine ribonucleoside triphosphate binding

0.37	GO:0070062	extracellular exosome
0.32	GO:0005622	intracellular
0.30	GO:0016020	membrane

0.34	EC:2.1.1	GO:0008168
0.33	KEGG:R00130	GO:0004140

sp|O60890|OPHN1_HUMAN
Oligophrenin-1
Search

OPHN1

0.94	Rho GTPase-activating protein 42

0.74	GO:0043547	positive regulation of GTPase activity
0.60	GO:0007165	signal transduction
0.56	GO:0045198	establishment of epithelial cell apical/basal polarity
0.56	GO:0021684	cerebellar granular layer formation
0.55	GO:0021895	cerebral cortex neuron differentiation
0.55	GO:0021533	cell differentiation in hindbrain
0.53	GO:0034329	cell junction assembly
0.53	GO:0051966	regulation of synaptic transmission, glutamatergic
0.53	GO:0048488	synaptic vesicle endocytosis
0.53	GO:1901799	negative regulation of proteasomal protein catabolic process

0.75	GO:0005096	GTPase activator activity
0.49	GO:0005543	phospholipid binding
0.48	GO:0003779	actin binding
0.40	GO:0035255	ionotropic glutamate receptor binding

0.54	GO:0043197	dendritic spine
0.53	GO:0043195	terminal bouton
0.48	GO:0015629	actin cytoskeleton
0.40	GO:0030054	cell junction
0.38	GO:0005737	cytoplasm

sp|O60894|RAMP1_HUMAN
Receptor activity-modifying protein 1
Search

RAMP1

0.96	Receptor activity-modifying protein 1

0.84	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.69	GO:0006886	intracellular protein transport
0.67	GO:1990408	calcitonin gene-related peptide receptor signaling pathway
0.66	GO:0097647	amylin receptor signaling pathway
0.66	GO:0060050	positive regulation of protein glycosylation
0.63	GO:0030816	positive regulation of cAMP metabolic process
0.63	GO:0031623	receptor internalization
0.61	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
0.61	GO:0072659	protein localization to plasma membrane
0.60	GO:0001525	angiogenesis

0.71	GO:0008565	protein transporter activity
0.69	GO:1990407	calcitonin gene-related peptide binding
0.67	GO:0001635	calcitonin gene-related peptide receptor activity
0.67	GO:0097643	amylin receptor activity
0.63	GO:0015026	coreceptor activity
0.39	GO:0031716	calcitonin receptor binding
0.38	GO:0004948	calcitonin receptor activity
0.36	GO:0046982	protein heterodimerization activity
0.35	GO:0030246	carbohydrate binding
0.34	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds

0.67	GO:1990406	CGRP receptor complex
0.67	GO:1903440	amylin receptor complex
0.56	GO:0009986	cell surface
0.45	GO:0005622	intracellular
0.42	GO:0005615	extracellular space

0.34

EC:3.2.1

GO:0004553

sp|O60895|RAMP2_HUMAN
Receptor activity-modifying protein 2
Search

RAMP2

0.97	Receptor activity-modifying protein 2

0.84	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.74	GO:0043116	negative regulation of vascular permeability
0.73	GO:1990410	adrenomedullin receptor signaling pathway
0.73	GO:0097647	amylin receptor signaling pathway
0.73	GO:2000352	negative regulation of endothelial cell apoptotic process
0.72	GO:0097084	vascular smooth muscle cell development
0.72	GO:0070830	bicellular tight junction assembly
0.71	GO:0070831	basement membrane assembly
0.71	GO:2001214	positive regulation of vasculogenesis
0.71	GO:0031623	receptor internalization

0.75	GO:1990409	adrenomedullin binding
0.74	GO:0097643	amylin receptor activity
0.74	GO:0001605	adrenomedullin receptor activity
0.71	GO:0008565	protein transporter activity
0.69	GO:0015026	coreceptor activity
0.37	GO:0005515	protein binding

0.74	GO:1903440	amylin receptor complex
0.73	GO:1903143	adrenomedullin receptor complex
0.62	GO:0009986	cell surface
0.45	GO:0005622	intracellular
0.39	GO:0005905	clathrin-coated pit
0.35	GO:0043227	membrane-bounded organelle

sp|O60896|RAMP3_HUMAN
Receptor activity-modifying protein 3
Search

RAMP3

0.97	Receptor activity-modifying protein 3

0.84	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
0.69	GO:0006886	intracellular protein transport
0.60	GO:0097646	calcitonin family receptor signaling pathway
0.59	GO:0038042	dimeric G-protein coupled receptor signaling pathway
0.57	GO:0030816	positive regulation of cAMP metabolic process
0.56	GO:0031623	receptor internalization
0.56	GO:1905665	positive regulation of calcium ion import across plasma membrane
0.56	GO:0001921	positive regulation of receptor recycling
0.56	GO:0086103	G-protein coupled receptor signaling pathway involved in heart process
0.56	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway

0.71	GO:0008565	protein transporter activity
0.60	GO:0097643	amylin receptor activity
0.57	GO:0001605	adrenomedullin receptor activity
0.55	GO:0015026	coreceptor activity
0.43	GO:1990407	calcitonin gene-related peptide binding
0.42	GO:0001635	calcitonin gene-related peptide receptor activity
0.36	GO:0001664	G-protein coupled receptor binding
0.35	GO:0046982	protein heterodimerization activity
0.34	GO:0004948	calcitonin receptor activity

0.59	GO:1903440	amylin receptor complex
0.57	GO:1903143	adrenomedullin receptor complex
0.51	GO:0009986	cell surface
0.51	GO:0005764	lysosome
0.42	GO:1990406	CGRP receptor complex
0.35	GO:0005615	extracellular space

sp|O60902|SHOX2_HUMAN
Short stature homeobox protein 2
Search

SHOX2

0.96	Short stature homeobox transcript variant SHOXa

0.64	GO:0007275	multicellular organism development
0.56	GO:2000172	regulation of branching morphogenesis of a nerve
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.55	GO:0010468	regulation of gene expression
0.55	GO:0048743	positive regulation of skeletal muscle fiber development
0.54	GO:0002053	positive regulation of mesenchymal cell proliferation
0.54	GO:0045880	positive regulation of smoothened signaling pathway
0.54	GO:0001503	ossification
0.53	GO:0032330	regulation of chondrocyte differentiation

0.63	GO:0043565	sequence-specific DNA binding
0.41	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.36	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
0.33	GO:0005515	protein binding

0.61	GO:0005634	nucleus
0.39	GO:0043233	organelle lumen
0.37	GO:0044446	intracellular organelle part

sp|O60906|NSMA_HUMAN
Sphingomyelin phosphodiesterase 2
Search

SMPD2

0.97	Sphingomyelin phosphodiesterase 2, neutral membrane (Neutral sphingomyelinase)

0.42	GO:0046513	ceramide biosynthetic process
0.40	GO:0009612	response to mechanical stimulus
0.39	GO:0006684	sphingomyelin metabolic process
0.38	GO:0071502	cellular response to temperature stimulus
0.37	GO:2000304	positive regulation of ceramide biosynthetic process
0.37	GO:0035556	intracellular signal transduction
0.37	GO:0090520	sphingolipid mediated signaling pathway
0.36	GO:0006687	glycosphingolipid metabolic process
0.36	GO:0071466	cellular response to xenobiotic stimulus
0.35	GO:0043065	positive regulation of apoptotic process

0.61	GO:0004767	sphingomyelin phosphodiesterase activity
0.35	GO:0046872	metal ion binding
0.34	GO:0005515	protein binding
0.32	GO:0004527	exonuclease activity
0.32	GO:0004519	endonuclease activity
0.31	GO:0003676	nucleic acid binding

0.40	GO:0005901	caveola
0.35	GO:0005794	Golgi apparatus
0.34	GO:0005887	integral component of plasma membrane

0.61	EC:3.1.4.12	GO:0004767
0.61	KEGG:R02541	GO:0004767

sp|O60907|TBL1X_HUMAN
F-box-like/WD repeat-containing protein TBL1X
Search

TBL1X

0.95	Transducin beta like 1, Y-linked

0.73	GO:0090263	positive regulation of canonical Wnt signaling pathway
0.70	GO:1903507	negative regulation of nucleic acid-templated transcription
0.69	GO:0006357	regulation of transcription by RNA polymerase II
0.66	GO:0045893	positive regulation of transcription, DNA-templated
0.64	GO:0016575	histone deacetylation
0.64	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
0.62	GO:0010629	negative regulation of gene expression
0.61	GO:0045444	fat cell differentiation
0.58	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.57	GO:0007605	sensory perception of sound

0.80	GO:0003714	transcription corepressor activity
0.72	GO:0008013	beta-catenin binding
0.69	GO:0042393	histone binding
0.67	GO:0044212	transcription regulatory region DNA binding
0.64	GO:0047485	protein N-terminus binding
0.53	GO:0008022	protein C-terminus binding
0.50	GO:0019904	protein domain specific binding
0.49	GO:0003682	chromatin binding
0.48	GO:0008134	transcription factor binding
0.42	GO:0042802	identical protein binding

0.78	GO:0000118	histone deacetylase complex
0.71	GO:0005876	spindle microtubule
0.71	GO:0017053	transcriptional repressor complex
0.48	GO:0005667	transcription factor complex
0.30	GO:0031224	intrinsic component of membrane

sp|O60909|B4GT2_HUMAN
Beta-1,4-galactosyltransferase 2
Search

B4GALT2

0.92	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2

0.60	GO:0005975	carbohydrate metabolic process
0.55	GO:0021680	cerebellar Purkinje cell layer development
0.55	GO:0008542	visual learning
0.54	GO:0007613	memory
0.53	GO:0007626	locomotory behavior
0.45	GO:0060058	positive regulation of apoptotic process involved in mammary gland involution
0.45	GO:0007341	penetration of zona pellucida
0.45	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing
0.45	GO:0045136	development of secondary sexual characteristics
0.44	GO:0060046	regulation of acrosome reaction

0.65	GO:0016757	transferase activity, transferring glycosyl groups
0.40	GO:0030145	manganese ion binding
0.40	GO:0008092	cytoskeletal protein binding
0.33	GO:0042803	protein homodimerization activity
0.33	GO:0015078	hydrogen ion transmembrane transporter activity

0.51	GO:0005794	Golgi apparatus
0.48	GO:0005654	nucleoplasm
0.44	GO:0030057	desmosome
0.44	GO:0031526	brush border membrane
0.43	GO:0016323	basolateral plasma membrane
0.42	GO:0009897	external side of plasma membrane
0.41	GO:0031984	organelle subcompartment
0.40	GO:0005615	extracellular space
0.37	GO:0098588	bounding membrane of organelle
0.35	GO:0005829	cytosol

0.65

GO:0016757

sp|O60911|CATL2_HUMAN
Cathepsin L2
Search

0.71	Cathepsin V

0.61	GO:0006508	proteolysis
0.50	GO:0010839	negative regulation of keratinocyte proliferation
0.50	GO:0046697	decidualization
0.50	GO:0031069	hair follicle morphogenesis
0.49	GO:2000249	regulation of actin cytoskeleton reorganization
0.47	GO:0044257	cellular protein catabolic process
0.45	GO:0097067	cellular response to thyroid hormone stimulus
0.44	GO:0030574	collagen catabolic process
0.44	GO:0051604	protein maturation
0.43	GO:0002250	adaptive immune response

0.72	GO:0008234	cysteine-type peptidase activity
0.50	GO:0042393	histone binding
0.47	GO:0097655	serpin family protein binding
0.45	GO:0004175	endopeptidase activity
0.45	GO:0001968	fibronectin binding
0.44	GO:0004180	carboxypeptidase activity
0.44	GO:0043394	proteoglycan binding
0.43	GO:0032403	protein complex binding
0.42	GO:0030984	kininogen binding
0.39	GO:0042277	peptide binding

0.55	GO:0005764	lysosome
0.51	GO:0005615	extracellular space
0.45	GO:0031410	cytoplasmic vesicle
0.44	GO:0005730	nucleolus
0.40	GO:0043204	perikaryon
0.40	GO:0005902	microvillus
0.39	GO:0009897	external side of plasma membrane
0.39	GO:0045177	apical part of cell
0.39	GO:0043005	neuron projection
0.37	GO:0012505	endomembrane system

0.72

GO:0008234

sp|O60921|HUS1_HUMAN
Checkpoint protein HUS1
Search

HUS1

0.93	HUS1 checkpoint clamp component

0.81	GO:0000077	DNA damage checkpoint
0.54	GO:0071479	cellular response to ionizing radiation
0.54	GO:0007093	mitotic cell cycle checkpoint
0.52	GO:0000724	double-strand break repair via homologous recombination
0.52	GO:0044778	meiotic DNA integrity checkpoint
0.51	GO:0008156	negative regulation of DNA replication
0.51	GO:0009411	response to UV
0.49	GO:0000076	DNA replication checkpoint
0.49	GO:0009790	embryo development
0.49	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle

0.33

GO:0005515

protein binding

0.84	GO:0030896	checkpoint clamp complex
0.73	GO:0005730	nucleolus
0.48	GO:0035861	site of double-strand break
0.34	GO:0005654	nucleoplasm
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O60925|PFD1_HUMAN
Prefoldin subunit 1
Search

PFDN1

0.91	Prefoldin subunit 1

0.69	GO:0006457	protein folding
0.44	GO:0007010	cytoskeleton organization
0.37	GO:0021549	cerebellum development
0.37	GO:0042113	B cell activation
0.36	GO:0021537	telencephalon development
0.35	GO:0030029	actin filament-based process
0.34	GO:0015948	methanogenesis
0.33	GO:0032259	methylation
0.33	GO:1903506	regulation of nucleic acid-templated transcription
0.33	GO:2000112	regulation of cellular macromolecule biosynthetic process

0.71	GO:0051082	unfolded protein binding
0.53	GO:0044183	protein binding involved in protein folding
0.35	GO:0042086	5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity
0.34	GO:0008172	S-methyltransferase activity
0.33	GO:0003700	DNA binding transcription factor activity

0.80	GO:0016272	prefoldin complex
0.36	GO:0005737	cytoplasm
0.30	GO:0031224	intrinsic component of membrane

0.34

GO:0008172

sp|O60927|PP1RB_HUMAN
Protein phosphatase 1 regulatory subunit 11
Search

PPP1R11

0.97	Phosphatase 1 regulatory subunit 11

0.83	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.57	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
0.44	GO:0050710	negative regulation of cytokine secretion
0.43	GO:0050830	defense response to Gram-positive bacterium
0.35	GO:0006379	mRNA cleavage
0.34	GO:0006470	protein dephosphorylation
0.33	GO:0006351	transcription, DNA-templated

0.85	GO:0004865	protein serine/threonine phosphatase inhibitor activity
0.54	GO:0061630	ubiquitin protein ligase activity
0.52	GO:0008157	protein phosphatase 1 binding
0.43	GO:0033608	formyl-CoA transferase activity
0.34	GO:0004721	phosphoprotein phosphatase activity
0.33	GO:0008270	zinc ion binding
0.32	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.32	GO:0003676	nucleic acid binding

0.51	GO:0000164	protein phosphatase type 1 complex
0.43	GO:0005634	nucleus
0.30	GO:0016020	membrane

0.43	EC:2.8.3.16	GO:0033608
0.43	KEGG:R07290	GO:0033608

sp|O60928|KCJ13_HUMAN
Inward rectifier potassium channel 13
Search

KCNJ13

0.97	Inward rectifier potassium channel 13

0.77	GO:0034765	regulation of ion transmembrane transport
0.71	GO:0006813	potassium ion transport
0.61	GO:0098655	cation transmembrane transport
0.45	GO:0051876	pigment granule dispersal
0.45	GO:0051877	pigment granule aggregation in cell center
0.44	GO:0097324	melanocyte migration
0.43	GO:0030318	melanocyte differentiation
0.41	GO:0098660	inorganic ion transmembrane transport
0.33	GO:0046662	regulation of oviposition
0.32	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway

0.83

GO:0005242

inward rectifier potassium channel activity

0.42	GO:0005887	integral component of plasma membrane
0.32	GO:0043025	neuronal cell body
0.32	GO:0043005	neuron projection

sp|O60930|RNH1_HUMAN
Ribonuclease H1
Search

RNASEH1

0.66	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

0.70	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
0.49	GO:0043137	DNA replication, removal of RNA primer
0.38	GO:0006264	mitochondrial DNA replication
0.34	GO:0019509	L-methionine salvage from methylthioadenosine
0.32	GO:0055114	oxidation-reduction process

0.74	GO:0004523	RNA-DNA hybrid ribonuclease activity
0.62	GO:0000287	magnesium ion binding
0.51	GO:0003676	nucleic acid binding
0.36	GO:0042803	protein homodimerization activity
0.35	GO:0010309	acireductone dioxygenase [iron(II)-requiring] activity
0.33	GO:0005506	iron ion binding

0.41	GO:0005634	nucleus
0.34	GO:0005739	mitochondrion
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.74	EC:3.1.26.4	GO:0004523
0.35	KEGG:R07364	GO:0010309

sp|O60931|CTNS_HUMAN
Cystinosin
Search

CTNS

0.91	Cystinosin, lysosomal cystine transporter

0.63	GO:0015811	L-cystine transport
0.60	GO:0007625	grooming behavior
0.59	GO:0007628	adult walking behavior
0.59	GO:0008542	visual learning
0.58	GO:0007616	long-term memory
0.58	GO:0002088	lens development in camera-type eye
0.54	GO:0007420	brain development
0.52	GO:0006749	glutathione metabolic process
0.46	GO:0046034	ATP metabolic process
0.44	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process

0.63	GO:0015184	L-cystine transmembrane transporter activity
0.33	GO:0003684	damaged DNA binding

0.57	GO:0005765	lysosomal membrane
0.55	GO:0005770	late endosome
0.54	GO:0045111	intermediate filament cytoskeleton
0.39	GO:0042470	melanosome
0.38	GO:0070062	extracellular exosome
0.38	GO:0005769	early endosome
0.35	GO:0005886	plasma membrane
0.33	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

sp|O60934|NBN_HUMAN
Nibrin
Search

NBN

0.94	Nijmegen breakage syndrome 1 (Fragment)

0.79	GO:0007093	mitotic cell cycle checkpoint
0.77	GO:0000723	telomere maintenance
0.66	GO:0051321	meiotic cell cycle
0.64	GO:0006281	DNA repair
0.60	GO:0031572	G2 DNA damage checkpoint
0.60	GO:0002204	somatic recombination of immunoglobulin genes involved in immune response
0.60	GO:0001325	formation of extrachromosomal circular DNA
0.59	GO:1904354	negative regulation of telomere capping
0.59	GO:0002312	B cell activation involved in immune response
0.59	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle

0.58	GO:0047485	protein N-terminus binding
0.52	GO:0003684	damaged DNA binding
0.52	GO:0008134	transcription factor binding
0.52	GO:0004003	ATP-dependent DNA helicase activity

0.83	GO:0030870	Mre11 complex
0.68	GO:0000781	chromosome, telomeric region
0.60	GO:0042405	nuclear inclusion body
0.57	GO:0016605	PML body
0.55	GO:0035861	site of double-strand break
0.52	GO:0044454	nuclear chromosome part
0.51	GO:0005657	replication fork
0.51	GO:0005730	nucleolus
0.34	GO:0005829	cytosol
0.30	GO:0016020	membrane

sp|O60936|NOL3_HUMAN
Nucleolar protein 3
Search

NOL3

0.97	Apoptosis repressor interacting with CARD

0.71	GO:0042981	regulation of apoptotic process
0.67	GO:0014876	response to injury involved in regulation of muscle adaptation
0.67	GO:0014736	negative regulation of muscle atrophy
0.66	GO:0010659	cardiac muscle cell apoptotic process
0.66	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process
0.63	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
0.63	GO:0060547	negative regulation of necrotic cell death
0.63	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
0.63	GO:0097340	inhibition of cysteine-type endopeptidase activity
0.62	GO:0002931	response to ischemia

0.65	GO:0035877	death effector domain binding
0.64	GO:0005123	death receptor binding
0.63	GO:0089720	caspase binding
0.61	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
0.53	GO:0042802	identical protein binding
0.52	GO:0005509	calcium ion binding
0.37	GO:0019902	phosphatase binding
0.37	GO:0030306	ADP-ribosylation factor binding
0.36	GO:0019900	kinase binding
0.36	GO:0043565	sequence-specific DNA binding

0.60	GO:0016528	sarcoplasm
0.47	GO:0005739	mitochondrion
0.40	GO:0005730	nucleolus
0.39	GO:0005783	endoplasmic reticulum
0.36	GO:0005829	cytosol
0.35	GO:0005886	plasma membrane
0.35	GO:0005667	transcription factor complex
0.33	GO:0005576	extracellular region
0.33	GO:0097610	cell surface furrow
0.33	GO:0030496	midbody

0.34

GO:0016787

sp|O60938|KERA_HUMAN
Keratocan
Search

KERA

0.97

Keratocan

0.84	GO:0061303	cornea development in camera-type eye
0.58	GO:0007409	axonogenesis
0.41	GO:0042340	keratan sulfate catabolic process
0.41	GO:0018146	keratan sulfate biosynthetic process
0.40	GO:0007601	visual perception
0.36	GO:0007569	cell aging
0.36	GO:0050896	response to stimulus
0.33	GO:0030199	collagen fibril organization

0.51

GO:0005201

extracellular matrix structural constituent

0.62	GO:0005578	proteinaceous extracellular matrix
0.55	GO:0005615	extracellular space
0.40	GO:0043202	lysosomal lumen
0.40	GO:0005796	Golgi lumen

sp|O60939|SCN2B_HUMAN
Sodium channel subunit beta-2
Search

SCN2B

0.97	Sodium voltage-gated channel beta subunit 2

0.66	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
0.66	GO:0086012	membrane depolarization during cardiac muscle cell action potential
0.66	GO:0065009	regulation of molecular function
0.64	GO:0086002	cardiac muscle cell action potential involved in contraction
0.64	GO:0086091	regulation of heart rate by cardiac conduction
0.63	GO:1902305	regulation of sodium ion transmembrane transport
0.59	GO:0035725	sodium ion transmembrane transport
0.47	GO:0046684	response to pyrethroid
0.41	GO:0007399	nervous system development
0.39	GO:0046629	gamma-delta T cell activation

0.85	GO:0017080	sodium channel regulator activity
0.67	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential
0.40	GO:0022832	voltage-gated channel activity
0.40	GO:0022839	ion gated channel activity
0.40	GO:0008381	mechanosensitive ion channel activity
0.34	GO:0005515	protein binding

0.83

GO:0001518

voltage-gated sodium channel complex

sp|O60941|DTNB_HUMAN
Dystrobrevin beta
Search

DTNB

0.88	Dystrobrevin beta

0.62	GO:0008270	zinc ion binding
0.35	GO:0005515	protein binding

0.49	GO:0045202	synapse
0.47	GO:0005737	cytoplasm
0.33	GO:0043234	protein complex

sp|O60942|MCE1_HUMAN
mRNA-capping enzyme
Search

RNGTT

0.86	mRNA-capping enzyme

0.83	GO:0098507	polynucleotide 5' dephosphorylation
0.75	GO:0006370	7-methylguanosine mRNA capping
0.74	GO:0035335	peptidyl-tyrosine dephosphorylation
0.34	GO:0006366	transcription by RNA polymerase II
0.33	GO:0016032	viral process
0.33	GO:0007018	microtubule-based movement

0.84	GO:0004484	mRNA guanylyltransferase activity
0.83	GO:0004651	polynucleotide 5'-phosphatase activity
0.78	GO:0008138	protein tyrosine/serine/threonine phosphatase activity
0.74	GO:0004725	protein tyrosine phosphatase activity
0.60	GO:0032550	purine ribonucleoside binding
0.60	GO:0019001	guanyl nucleotide binding
0.59	GO:0050355	triphosphatase activity
0.50	GO:0032555	purine ribonucleotide binding
0.50	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0005515	protein binding

0.60	GO:0005634	nucleus
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part
0.33	GO:0015629	actin cytoskeleton
0.32	GO:0043234	protein complex

0.84	EC:2.7.7.50	GO:0004484
0.59	KEGG:R00138	GO:0050355

sp|O75015|FCG3B_HUMAN
Low affinity immunoglobulin gamma Fc region receptor III-B
Search

0.92	Low affinity immunoglobulin gamma Fc region receptor III-B

0.53	GO:0038094	Fc-gamma receptor signaling pathway
0.50	GO:0002274	myeloid leukocyte activation
0.46	GO:0038095	Fc-epsilon receptor signaling pathway
0.46	GO:0045780	positive regulation of bone resorption
0.44	GO:0002252	immune effector process
0.44	GO:0006909	phagocytosis
0.44	GO:0001810	regulation of type I hypersensitivity
0.44	GO:0071219	cellular response to molecule of bacterial origin
0.43	GO:0006955	immune response
0.43	GO:0002431	Fc receptor mediated stimulatory signaling pathway

0.61	GO:0019864	IgG binding
0.52	GO:0019770	IgG receptor activity
0.48	GO:0019767	IgE receptor activity
0.41	GO:0019863	IgE binding
0.38	GO:0001540	amyloid-beta binding
0.37	GO:0034987	immunoglobulin receptor binding
0.35	GO:0005057	signal transducer activity, downstream of receptor

0.48	GO:0009986	cell surface
0.45	GO:0070062	extracellular exosome
0.45	GO:0098552	side of membrane
0.43	GO:0005886	plasma membrane
0.39	GO:0030667	secretory granule membrane
0.38	GO:0031225	anchored component of membrane
0.38	GO:0043197	dendritic spine
0.37	GO:0044297	cell body
0.35	GO:0055037	recycling endosome
0.35	GO:0098857	membrane microdomain

sp|O75019|LIRA1_HUMAN
Leukocyte immunoglobulin-like receptor subfamily A member 1
Search

0.96	Leukocyte immunoglobulin like receptor A4

0.48	GO:0002768	immune response-regulating cell surface receptor signaling pathway
0.47	GO:0006955	immune response
0.46	GO:0032480	negative regulation of type I interferon production
0.46	GO:0032720	negative regulation of tumor necrosis factor production
0.45	GO:0045321	leukocyte activation
0.45	GO:0034122	negative regulation of toll-like receptor signaling pathway
0.44	GO:0002252	immune effector process
0.44	GO:0002765	immune response-inhibiting signal transduction
0.44	GO:2001198	regulation of dendritic cell differentiation
0.43	GO:2001191	regulation of gamma-delta T cell activation involved in immune response

0.45	GO:0032396	inhibitory MHC class I receptor activity
0.43	GO:0042288	MHC class I protein binding
0.41	GO:0015026	coreceptor activity
0.40	GO:0001791	IgM binding
0.40	GO:0001540	amyloid-beta binding
0.40	GO:0003823	antigen binding
0.39	GO:0008157	protein phosphatase 1 binding
0.37	GO:0023029	MHC class Ib protein binding
0.37	GO:0042803	protein homodimerization activity
0.37	GO:0042169	SH2 domain binding

0.43	GO:0032998	Fc-epsilon receptor I complex
0.41	GO:0106003	amyloid-beta complex
0.41	GO:0005887	integral component of plasma membrane
0.40	GO:0030667	secretory granule membrane
0.40	GO:0009986	cell surface
0.40	GO:0101002	ficolin-1-rich granule
0.39	GO:0070820	tertiary granule
0.39	GO:0098552	side of membrane
0.37	GO:0005576	extracellular region
0.37	GO:0042581	specific granule

sp|O75022|LIRB3_HUMAN
Leukocyte immunoglobulin-like receptor subfamily B member 3
Search

0.96	Leukocyte immunoglobulin like receptor B5

0.46	GO:0002250	adaptive immune response
0.45	GO:0002768	immune response-regulating cell surface receptor signaling pathway
0.44	GO:0002366	leukocyte activation involved in immune response
0.44	GO:0032480	negative regulation of type I interferon production
0.43	GO:0032720	negative regulation of tumor necrosis factor production
0.43	GO:0002683	negative regulation of immune system process
0.42	GO:1902105	regulation of leukocyte differentiation
0.42	GO:0042119	neutrophil activation
0.42	GO:0002765	immune response-inhibiting signal transduction
0.42	GO:0006952	defense response

0.43	GO:0032396	inhibitory MHC class I receptor activity
0.42	GO:0001540	amyloid-beta binding
0.41	GO:0042288	MHC class I protein binding
0.40	GO:0015026	coreceptor activity
0.39	GO:0008157	protein phosphatase 1 binding
0.38	GO:0001791	IgM binding
0.37	GO:0042803	protein homodimerization activity
0.37	GO:0042169	SH2 domain binding
0.36	GO:0023029	MHC class Ib protein binding
0.36	GO:0003823	antigen binding

0.43	GO:0106003	amyloid-beta complex
0.41	GO:0032998	Fc-epsilon receptor I complex
0.40	GO:0030667	secretory granule membrane
0.40	GO:0005887	integral component of plasma membrane
0.39	GO:0009986	cell surface
0.37	GO:0098552	side of membrane
0.37	GO:0101002	ficolin-1-rich granule
0.37	GO:0070820	tertiary granule
0.36	GO:0005576	extracellular region
0.33	GO:0042581	specific granule

sp|O75023|LIRB5_HUMAN
Leukocyte immunoglobulin-like receptor subfamily B member 5
Search

0.95	Leukocyte immunoglobulin like receptor B5

0.49	GO:0002250	adaptive immune response
0.46	GO:0002768	immune response-regulating cell surface receptor signaling pathway
0.44	GO:0002366	leukocyte activation involved in immune response
0.44	GO:0032480	negative regulation of type I interferon production
0.44	GO:0002683	negative regulation of immune system process
0.44	GO:0032720	negative regulation of tumor necrosis factor production
0.43	GO:0006952	defense response
0.43	GO:0034121	regulation of toll-like receptor signaling pathway
0.43	GO:0042119	neutrophil activation
0.42	GO:1902105	regulation of leukocyte differentiation

0.43	GO:0032396	inhibitory MHC class I receptor activity
0.42	GO:0005102	receptor binding
0.41	GO:0015026	coreceptor activity
0.41	GO:0001540	amyloid-beta binding
0.38	GO:0032403	protein complex binding
0.38	GO:0008157	protein phosphatase 1 binding
0.37	GO:0050839	cell adhesion molecule binding
0.37	GO:0042803	protein homodimerization activity

0.43	GO:0032998	Fc-epsilon receptor I complex
0.42	GO:0106003	amyloid-beta complex
0.41	GO:0005887	integral component of plasma membrane
0.41	GO:0030667	secretory granule membrane
0.39	GO:0009986	cell surface
0.39	GO:0101002	ficolin-1-rich granule
0.39	GO:0070820	tertiary granule
0.36	GO:0005615	extracellular space
0.36	GO:0098552	side of membrane

sp|O75027|ABCB7_HUMAN
ATP-binding cassette sub-family B member 7, mitochondrial
Search

ABCB7

0.91	ATP-binding cassette sub-family B member 7, mitochondrial

0.56	GO:0006879	cellular iron ion homeostasis
0.53	GO:0055085	transmembrane transport
0.36	GO:0000188	inactivation of MAPK activity
0.35	GO:0006470	protein dephosphorylation
0.35	GO:0015886	heme transport

0.63	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.53	GO:0032559	adenyl ribonucleotide binding
0.52	GO:0008144	drug binding
0.52	GO:0035639	purine ribonucleoside triphosphate binding
0.36	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
0.35	GO:0015232	heme transporter activity

0.48	GO:0031966	mitochondrial membrane
0.48	GO:0019866	organelle inner membrane
0.30	GO:0031224	intrinsic component of membrane

0.36

GO:0017017

sp|O75030|MITF_HUMAN
Microphthalmia-associated transcription factor
Search

MITF

0.91	Microphthalmia-associated transcription factor variant

0.69	GO:0006357	regulation of transcription by RNA polymerase II
0.55	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process
0.55	GO:0030318	melanocyte differentiation
0.53	GO:0030316	osteoclast differentiation
0.53	GO:2000144	positive regulation of DNA-templated transcription, initiation
0.53	GO:0046849	bone remodeling
0.53	GO:0045670	regulation of osteoclast differentiation
0.51	GO:0043010	camera-type eye development
0.50	GO:0045165	cell fate commitment
0.49	GO:0006366	transcription by RNA polymerase II

0.67	GO:0046983	protein dimerization activity
0.60	GO:0003700	DNA binding transcription factor activity
0.54	GO:0070888	E-box binding
0.49	GO:0003682	chromatin binding

0.60	GO:0005634	nucleus
0.42	GO:0043234	protein complex
0.34	GO:0031974	membrane-enclosed lumen
0.33	GO:0044446	intracellular organelle part

sp|O75031|HSF2B_HUMAN
Heat shock factor 2-binding protein
Search

HSF2BP

0.97	heat shock factor 2-binding protein isoform X1

0.57	GO:0007283	spermatogenesis
0.54	GO:0006366	transcription by RNA polymerase II

0.54

GO:0005515

protein binding

0.64

GO:0005829

cytosol

sp|O75037|KI21B_HUMAN
Kinesin-like protein KIF21B
Search

KIF21B

0.92	Kinesin family member 21B

0.74

GO:0007018

microtubule-based movement

0.75	GO:0003777	microtubule motor activity
0.73	GO:0008017	microtubule binding
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0097367	carbohydrate derivative binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.43	GO:0016887	ATPase activity

0.52	GO:0005871	kinesin complex
0.35	GO:0005829	cytosol
0.34	GO:0005886	plasma membrane
0.30	GO:0044425	membrane part

0.43

GO:0016887

sp|O75038|PLCH2_HUMAN
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
Search

PLCH2

0.53	Phosphoinositide phospholipase C

0.72	GO:0016042	lipid catabolic process
0.63	GO:0035556	intracellular signal transduction
0.49	GO:0046488	phosphatidylinositol metabolic process
0.36	GO:0060079	excitatory postsynaptic potential
0.36	GO:0035235	ionotropic glutamate receptor signaling pathway
0.34	GO:0006811	ion transport

0.82	GO:0004435	phosphatidylinositol phospholipase C activity
0.69	GO:0005509	calcium ion binding
0.63	GO:0004871	signal transducer activity
0.57	GO:0050429	calcium-dependent phospholipase C activity
0.36	GO:0005230	extracellular ligand-gated ion channel activity
0.35	GO:0099600	transmembrane receptor activity

0.45	GO:0005622	intracellular
0.41	GO:0005886	plasma membrane
0.36	GO:0098794	postsynapse
0.33	GO:0043227	membrane-bounded organelle
0.30	GO:0016021	integral component of membrane

0.82	EC:3.1.4.11	GO:0004435
0.82	KEGG:R03435	GO:0004435

sp|O75044|SRGP2_HUMAN
SLIT-ROBO Rho GTPase-activating protein 2
Search

SRGAP2

0.96	SLIT-ROBO Rho GTPase activating protein 2

0.74	GO:0043547	positive regulation of GTPase activity
0.60	GO:0007165	signal transduction
0.56	GO:0021816	extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
0.54	GO:0046847	filopodium assembly
0.54	GO:0060996	dendritic spine development
0.50	GO:0048812	neuron projection morphogenesis
0.45	GO:0030336	negative regulation of cell migration
0.42	GO:0003363	lamellipodium assembly involved in ameboidal cell migration
0.42	GO:2001222	regulation of neuron migration
0.41	GO:0051014	actin filament severing

0.74	GO:0005096	GTPase activator activity
0.55	GO:0048365	Rac GTPase binding
0.48	GO:0042803	protein homodimerization activity
0.33	GO:0046982	protein heterodimerization activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.52	GO:0045335	phagocytic vesicle
0.52	GO:0014069	postsynaptic density
0.50	GO:0045211	postsynaptic membrane
0.46	GO:0005829	cytosol
0.43	GO:0044327	dendritic spine head
0.42	GO:0031966	mitochondrial membrane
0.42	GO:0019866	organelle inner membrane
0.40	GO:0030027	lamellipodium
0.39	GO:0030054	cell junction
0.38	GO:0005634	nucleus

sp|O75051|PLXA2_HUMAN
Plexin-A2
Search

0.83	GO:0071526	semaphorin-plexin signaling pathway
0.60	GO:0021935	cerebellar granule cell precursor tangential migration
0.57	GO:0060174	limb bud formation
0.56	GO:0060037	pharyngeal system development
0.56	GO:0051642	centrosome localization
0.55	GO:0001756	somitogenesis
0.54	GO:0021915	neural tube development
0.54	GO:0051270	regulation of cellular component movement
0.53	GO:0040012	regulation of locomotion
0.52	GO:0021785	branchiomotor neuron axon guidance

0.84	GO:0017154	semaphorin receptor activity
0.50	GO:0042802	identical protein binding

0.47	GO:0005887	integral component of plasma membrane
0.37	GO:0002116	semaphorin receptor complex

sp|O75052|CAPON_HUMAN
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
Search

NOS1AP

0.95	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 1

0.86	GO:0003062	regulation of heart rate by chemical signal
0.84	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
0.53	GO:1902514	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
0.52	GO:1901841	regulation of high voltage-gated calcium channel activity
0.51	GO:0098901	regulation of cardiac muscle cell action potential
0.51	GO:0050999	regulation of nitric-oxide synthase activity
0.51	GO:0045428	regulation of nitric oxide biosynthetic process
0.50	GO:2000170	positive regulation of peptidyl-cysteine S-nitrosylation
0.50	GO:0010750	positive regulation of nitric oxide mediated signal transduction
0.49	GO:1903116	positive regulation of actin filament-based movement

0.84	GO:0050998	nitric-oxide synthase binding
0.42	GO:0030165	PDZ domain binding
0.42	GO:0002020	protease binding
0.41	GO:0004672	protein kinase activity
0.38	GO:0030554	adenyl nucleotide binding
0.37	GO:0097367	carbohydrate derivative binding
0.37	GO:0008144	drug binding
0.37	GO:0035639	purine ribonucleoside triphosphate binding
0.37	GO:0003676	nucleic acid binding

0.81	GO:0030315	T-tubule
0.81	GO:0033017	sarcoplasmic reticulum membrane
0.78	GO:0005901	caveola
0.78	GO:0030018	Z disc
0.57	GO:0005739	mitochondrion
0.49	GO:1902937	inward rectifier potassium channel complex
0.45	GO:0005891	voltage-gated calcium channel complex
0.45	GO:0031965	nuclear membrane
0.45	GO:0048471	perinuclear region of cytoplasm
0.42	GO:0005829	cytosol

sp|O75054|IGSF3_HUMAN
Immunoglobulin superfamily member 3
Search

0.78	LOW QUALITY PROTEIN: immunoglobulin superfamily member 3

0.57	GO:0032808	lacrimal gland development
0.49	GO:0002763	positive regulation of myeloid leukocyte differentiation
0.48	GO:0007166	cell surface receptor signaling pathway
0.37	GO:0007519	skeletal muscle tissue development
0.37	GO:0007338	single fertilization
0.37	GO:2000145	regulation of cell motility
0.36	GO:0008283	cell proliferation
0.36	GO:0007399	nervous system development
0.35	GO:0048870	cell motility

0.39	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
0.35	GO:0005515	protein binding

0.43	GO:0070062	extracellular exosome
0.43	GO:0005886	plasma membrane
0.37	GO:0043209	myelin sheath
0.37	GO:0030424	axon
0.36	GO:0045202	synapse
0.30	GO:0009986	cell surface
0.30	GO:0016021	integral component of membrane

0.39

EC:3.5.2

GO:0016812

sp|O75056|SDC3_HUMAN
Syndecan-3
Search

SDC3

0.82

Syndecan

0.47	GO:0016477	cell migration
0.45	GO:0042060	wound healing
0.43	GO:0048627	myoblast development
0.42	GO:1903553	positive regulation of extracellular exosome assembly
0.42	GO:1903543	positive regulation of exosomal secretion
0.41	GO:0060070	canonical Wnt signaling pathway
0.40	GO:0055002	striated muscle cell development
0.39	GO:0003419	growth plate cartilage chondrocyte proliferation
0.37	GO:0001523	retinoid metabolic process
0.37	GO:0035988	chondrocyte proliferation

0.54	GO:0042802	identical protein binding
0.40	GO:0008022	protein C-terminus binding
0.34	GO:0019838	growth factor binding
0.33	GO:0050840	extracellular matrix binding
0.32	GO:0003723	RNA binding

0.52	GO:0031012	extracellular matrix
0.49	GO:0009986	cell surface
0.40	GO:0005796	Golgi lumen
0.39	GO:0098552	side of membrane
0.38	GO:0043202	lysosomal lumen
0.37	GO:0044459	plasma membrane part
0.36	GO:0030424	axon
0.35	GO:0070062	extracellular exosome
0.34	GO:0043234	protein complex
0.30	GO:0031224	intrinsic component of membrane

sp|O75061|AUXI_HUMAN
Putative tyrosine-protein phosphatase auxilin
Search

DNAJC6

0.93	Putative tyrosine-protein phosphatase auxilin

0.81	GO:0072318	clathrin coat disassembly
0.73	GO:2000369	regulation of clathrin-dependent endocytosis
0.71	GO:0048488	synaptic vesicle endocytosis
0.64	GO:0035335	peptidyl-tyrosine dephosphorylation
0.55	GO:0006898	receptor-mediated endocytosis
0.46	GO:0061024	membrane organization

0.66	GO:0017124	SH3 domain binding
0.65	GO:0004725	protein tyrosine phosphatase activity
0.55	GO:0032050	clathrin heavy chain binding

0.68	GO:0014069	postsynaptic density
0.60	GO:0031982	vesicle
0.46	GO:0005829	cytosol
0.30	GO:0016020	membrane

0.65

GO:0004725

sp|O75063|XYLK_HUMAN
Glycosaminoglycan xylosylkinase
Search

FAM20B

0.97	Glycosaminoglycan xylosylkinase

0.59	GO:1903955	positive regulation of protein targeting to mitochondrion
0.52	GO:0016310	phosphorylation
0.37	GO:0048701	embryonic cranial skeleton morphogenesis
0.37	GO:0030166	proteoglycan biosynthetic process

0.55	GO:0016772	transferase activity, transferring phosphorus-containing groups
0.35	GO:0032559	adenyl ribonucleotide binding
0.35	GO:0008144	drug binding
0.35	GO:0035639	purine ribonucleoside triphosphate binding
0.34	GO:0046872	metal ion binding
0.33	GO:0005515	protein binding

0.52	GO:0005615	extracellular space
0.52	GO:0005794	Golgi apparatus
0.50	GO:0005654	nucleoplasm
0.37	GO:0098588	bounding membrane of organelle
0.36	GO:0031984	organelle subcompartment
0.30	GO:0016021	integral component of membrane

0.55

GO:0016772

sp|O75064|DEN4B_HUMAN
DENN domain-containing protein 4B
Search

DENND4B

0.94	DENN domain-containing protein 4B

0.84	GO:0032483	regulation of Rab protein signal transduction
0.64	GO:0065009	regulation of molecular function

0.81

GO:0017112

Rab guanyl-nucleotide exchange factor activity

0.67	GO:0005794	Golgi apparatus
0.58	GO:0005634	nucleus
0.48	GO:0000813	ESCRT I complex
0.38	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O75069|TMCC2_HUMAN
Transmembrane and coiled-coil domains protein 2
Search

TMCC2

0.97	Transmembrane and coiled-coil domains protein 2

0.58

GO:0042982

amyloid precursor protein metabolic process

0.34

GO:0005515

protein binding

0.49	GO:0005783	endoplasmic reticulum
0.30	GO:0044425	membrane part

sp|O75071|EFC14_HUMAN
EF-hand calcium-binding domain-containing protein 14
Search

EFCAB14

0.95	EF-hand calcium-binding domain-containing protein 14

0.32

GO:0006461

protein complex assembly

0.63

GO:0005509

calcium ion binding

0.32	GO:0005739	mitochondrion
0.30	GO:0044425	membrane part

sp|O75072|FKTN_HUMAN
Fukutin
Search

FKTN

0.97	Patient fukutin

0.66	GO:0046329	negative regulation of JNK cascade
0.65	GO:0035269	protein O-linked mannosylation
0.60	GO:0008285	negative regulation of cell proliferation
0.49	GO:0060049	regulation of protein glycosylation
0.46	GO:0001570	vasculogenesis
0.46	GO:0048747	muscle fiber development
0.41	GO:0043486	histone exchange
0.38	GO:0007399	nervous system development
0.36	GO:0007517	muscle organ development
0.36	GO:0016477	cell migration

0.36	GO:0016740	transferase activity
0.35	GO:0005261	cation channel activity
0.33	GO:0015078	hydrogen ion transmembrane transporter activity

0.63	GO:0005801	cis-Golgi network
0.56	GO:0005794	Golgi apparatus
0.55	GO:0005783	endoplasmic reticulum
0.50	GO:0005634	nucleus
0.38	GO:0098588	bounding membrane of organelle
0.38	GO:0031984	organelle subcompartment
0.35	GO:0005615	extracellular space
0.35	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
0.30	GO:0016021	integral component of membrane

0.36

EC:2

GO:0016740

sp|O75074|LRP3_HUMAN
Low-density lipoprotein receptor-related protein 3
Search

LRP3

0.97	Low-density lipoprotein receptor-related protein 3

0.40	GO:0001764	neuron migration
0.39	GO:0031175	neuron projection development
0.36	GO:0006897	endocytosis
0.31	GO:0006397	mRNA processing

0.36

GO:0005515

protein binding

0.37	GO:0005905	clathrin-coated pit
0.36	GO:0005887	integral component of plasma membrane

sp|O75077|ADA23_HUMAN
Disintegrin and metalloproteinase domain-containing protein 23
Search

ADAM23

0.93	Disintegrin and metalloproteinase domain-containing protein 23

0.79	GO:0007229	integrin-mediated signaling pathway
0.61	GO:0006508	proteolysis
0.41	GO:1990830	cellular response to leukemia inhibitory factor
0.39	GO:0007155	cell adhesion
0.37	GO:0007417	central nervous system development

0.70	GO:0004222	metalloendopeptidase activity
0.38	GO:0005178	integrin binding

0.37	GO:0005576	extracellular region
0.36	GO:0005887	integral component of plasma membrane

0.70

GO:0004222

sp|O75078|ADA11_HUMAN
Disintegrin and metalloproteinase domain-containing protein 11
Search

ADAM11

0.96	ADAM metallopeptidase domain 11

0.61	GO:0006508	proteolysis
0.38	GO:0022011	myelination in peripheral nervous system
0.38	GO:0008344	adult locomotory behavior

0.70

GO:0004222

metalloendopeptidase activity

0.37	GO:0030424	axon
0.36	GO:0031012	extracellular matrix
0.30	GO:0031224	intrinsic component of membrane

0.70

GO:0004222

sp|O75081|MTG16_HUMAN
Protein CBFA2T3
Search

CBFA2T3

0.94	Core-binding factor, runt domain, alpha subunit 2; translocated to, 3

0.72	GO:0045892	negative regulation of transcription, DNA-templated
0.55	GO:0045820	negative regulation of glycolytic process
0.55	GO:1903715	regulation of aerobic respiration
0.54	GO:0030851	granulocyte differentiation
0.53	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.52	GO:0001666	response to hypoxia
0.50	GO:0008285	negative regulation of cell proliferation
0.38	GO:0045599	negative regulation of fat cell differentiation
0.37	GO:0045444	fat cell differentiation
0.37	GO:0051101	regulation of DNA binding

0.81	GO:0003714	transcription corepressor activity
0.61	GO:0003700	DNA binding transcription factor activity
0.37	GO:0003682	chromatin binding
0.36	GO:0005515	protein binding
0.34	GO:0046872	metal ion binding
0.34	GO:0003676	nucleic acid binding

0.51	GO:0005654	nucleoplasm
0.38	GO:0016363	nuclear matrix
0.36	GO:0005730	nucleolus
0.36	GO:0005794	Golgi apparatus
0.35	GO:0098588	bounding membrane of organelle
0.35	GO:0031984	organelle subcompartment
0.34	GO:0017053	transcriptional repressor complex

sp|O75083|WDR1_HUMAN
WD repeat-containing protein 1
Search

WDR1

0.96	WD repeat-containing protein 1

0.84	GO:0030043	actin filament fragmentation
0.84	GO:0042247	establishment of planar polarity of follicular epithelium
0.82	GO:0045199	maintenance of epithelial cell apical/basal polarity
0.80	GO:0030836	positive regulation of actin filament depolymerization
0.80	GO:0045214	sarcomere organization
0.79	GO:0030220	platelet formation
0.79	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
0.78	GO:0043297	apical junction assembly
0.78	GO:0002446	neutrophil mediated immunity
0.76	GO:1990266	neutrophil migration

0.59	GO:0051015	actin filament binding
0.34	GO:0022857	transmembrane transporter activity
0.30	GO:0003824	catalytic activity

0.73	GO:0043209	myelin sheath
0.70	GO:0005911	cell-cell junction
0.66	GO:0042643	actomyosin, actin portion
0.59	GO:0030864	cortical actin cytoskeleton
0.53	GO:0005886	plasma membrane
0.48	GO:0002102	podosome
0.42	GO:0042995	cell projection
0.42	GO:0070062	extracellular exosome
0.38	GO:0005634	nucleus
0.36	GO:0005829	cytosol

sp|O75084|FZD7_HUMAN
Frizzled-7
Search

FZD7

0.95	Frizzled class receptor 7

0.77	GO:0016055	Wnt signaling pathway
0.68	GO:0007275	multicellular organism development
0.59	GO:0060429	epithelium development
0.59	GO:0045995	regulation of embryonic development
0.56	GO:0035412	regulation of catenin import into nucleus
0.56	GO:2000384	negative regulation of ectoderm development
0.56	GO:0009653	anatomical structure morphogenesis
0.55	GO:0010562	positive regulation of phosphorus metabolic process
0.55	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
0.55	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing

0.85	GO:0042813	Wnt-activated receptor activity
0.61	GO:0017147	Wnt-protein binding
0.60	GO:0030165	PDZ domain binding
0.56	GO:0005109	frizzled binding
0.52	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
0.48	GO:0004930	G-protein coupled receptor activity
0.38	GO:0045545	syndecan binding
0.34	GO:0042803	protein homodimerization activity
0.34	GO:0046982	protein heterodimerization activity
0.33	GO:0004672	protein kinase activity

0.53	GO:0055038	recycling endosome membrane
0.45	GO:0005886	plasma membrane
0.40	GO:0009986	cell surface
0.37	GO:0005925	focal adhesion
0.35	GO:1990909	Wnt signalosome
0.34	GO:0030669	clathrin-coated endocytic vesicle membrane
0.34	GO:0043005	neuron projection
0.30	GO:0016021	integral component of membrane

sp|O75093|SLIT1_HUMAN
Slit homolog 1 protein
Search

SLIT1

0.95	Slit guidance ligand 1

0.58	GO:0022028	tangential migration from the subventricular zone to the olfactory bulb
0.58	GO:0048846	axon extension involved in axon guidance
0.58	GO:0033563	dorsal/ventral axon guidance
0.56	GO:0050919	negative chemotaxis
0.56	GO:0031290	retinal ganglion cell axon guidance
0.56	GO:0008045	motor neuron axon guidance
0.55	GO:0007097	nuclear migration
0.45	GO:0045773	positive regulation of axon extension
0.40	GO:0021891	olfactory bulb interneuron development
0.39	GO:0051964	negative regulation of synapse assembly

0.69	GO:0005509	calcium ion binding
0.59	GO:0048495	Roundabout binding
0.35	GO:0043237	laminin-1 binding
0.35	GO:0005095	GTPase inhibitor activity
0.35	GO:0043394	proteoglycan binding
0.34	GO:0008201	heparin binding
0.34	GO:0042803	protein homodimerization activity

0.57	GO:0005576	extracellular region
0.37	GO:0005622	intracellular
0.33	GO:0005886	plasma membrane
0.32	GO:0009986	cell surface
0.32	GO:0031982	vesicle
0.30	GO:0016021	integral component of membrane

sp|O75094|SLIT3_HUMAN
Slit homolog 3 protein
Search

SLIT3

0.95	Slit guidance ligand 3

0.61	GO:0061364	apoptotic process involved in luteolysis
0.61	GO:0070100	negative regulation of chemokine-mediated signaling pathway
0.61	GO:0051414	response to cortisol
0.60	GO:0030308	negative regulation of cell growth
0.60	GO:0048846	axon extension involved in axon guidance
0.59	GO:0050919	negative chemotaxis
0.59	GO:0035385	Roundabout signaling pathway
0.53	GO:0032870	cellular response to hormone stimulus
0.51	GO:0009887	animal organ morphogenesis
0.51	GO:0021954	central nervous system neuron development

0.70	GO:0005509	calcium ion binding
0.61	GO:0048495	Roundabout binding
0.46	GO:0043237	laminin-1 binding
0.46	GO:0005095	GTPase inhibitor activity
0.45	GO:0043394	proteoglycan binding
0.44	GO:0008201	heparin binding
0.42	GO:0042803	protein homodimerization activity
0.35	GO:0045499	chemorepellent activity
0.34	GO:0004594	pantothenate kinase activity
0.34	GO:0004963	follicle-stimulating hormone receptor activity

0.61	GO:0005576	extracellular region
0.36	GO:0005737	cytoplasm
0.34	GO:0043231	intracellular membrane-bounded organelle
0.33	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

0.34

EC:2.7.1.33

GO:0004594

sp|O75095|MEGF6_HUMAN
Multiple epidermal growth factor-like domains protein 6
Search

MEGF6

0.79	Multiple EGF like domains 6

0.39

GO:0001558

regulation of cell growth

0.70	GO:0005509	calcium ion binding
0.39	GO:0005520	insulin-like growth factor binding

0.40	GO:0005576	extracellular region
0.30	GO:0044425	membrane part

sp|O75096|LRP4_HUMAN
Low-density lipoprotein receptor-related protein 4
Search

LRP4

0.52	Low-density lipoprotein receptor-related protein 4

0.85	GO:0030509	BMP signaling pathway
0.82	GO:0060828	regulation of canonical Wnt signaling pathway
0.74	GO:0048513	animal organ development
0.41	GO:1901631	positive regulation of presynaptic membrane organization
0.40	GO:0071340	skeletal muscle acetylcholine-gated channel clustering
0.40	GO:0097105	presynaptic membrane assembly
0.40	GO:0097104	postsynaptic membrane assembly
0.40	GO:0051124	synaptic growth at neuromuscular junction
0.40	GO:0051290	protein heterotetramerization
0.40	GO:0050771	negative regulation of axonogenesis

0.68	GO:0005509	calcium ion binding
0.40	GO:0097110	scaffold protein binding
0.39	GO:0030971	receptor tyrosine kinase binding
0.39	GO:0017147	Wnt-protein binding
0.38	GO:0042813	Wnt-activated receptor activity
0.38	GO:0034185	apolipoprotein binding
0.36	GO:0042803	protein homodimerization activity

0.40	GO:0016600	flotillin complex
0.39	GO:0031594	neuromuscular junction
0.39	GO:0014069	postsynaptic density
0.39	GO:0043025	neuronal cell body
0.39	GO:0030425	dendrite
0.38	GO:0097060	synaptic membrane
0.38	GO:0009986	cell surface
0.37	GO:0043235	receptor complex
0.30	GO:0016021	integral component of membrane

sp|O75106|AOC2_HUMAN
Retina-specific copper amine oxidase
Search

0.49	Retina-specific copper amine oxidase

0.70	GO:0009308	amine metabolic process
0.66	GO:0007601	visual perception
0.53	GO:0055114	oxidation-reduction process
0.50	GO:1902283	negative regulation of primary amine oxidase activity
0.43	GO:0007155	cell adhesion
0.43	GO:0046677	response to antibiotic
0.38	GO:0006584	catecholamine metabolic process
0.36	GO:0006805	xenobiotic metabolic process
0.36	GO:0006954	inflammatory response
0.35	GO:0035902	response to immobilization stress

0.83	GO:0008131	primary amine oxidase activity
0.72	GO:0048038	quinone binding
0.72	GO:0005507	copper ion binding
0.46	GO:0052593	tryptamine:oxygen oxidoreductase (deaminating) activity
0.46	GO:0052596	phenethylamine:oxygen oxidoreductase (deaminating) activity
0.46	GO:0052594	aminoacetone:oxygen oxidoreductase(deaminating) activity
0.46	GO:0052595	aliphatic-amine oxidase activity
0.43	GO:0046982	protein heterodimerization activity
0.42	GO:0005509	calcium ion binding
0.35	GO:0042803	protein homodimerization activity

0.47	GO:0005902	microvillus
0.45	GO:0005769	early endosome
0.45	GO:0009986	cell surface
0.42	GO:0005794	Golgi apparatus
0.42	GO:0005783	endoplasmic reticulum
0.39	GO:0005886	plasma membrane
0.36	GO:0005615	extracellular space
0.35	GO:0008537	proteasome activator complex
0.30	GO:0016021	integral component of membrane

0.83	EC:1.4.3.21	GO:0008131
0.83	KEGG:R01853	GO:0008131

sp|O75110|ATP9A_HUMAN
Probable phospholipid-transporting ATPase IIA
Search

ATP9A

0.59	Phospholipid-transporting ATPase

0.79	GO:0045332	phospholipid translocation
0.46	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
0.43	GO:0006897	endocytosis

0.79	GO:0004012	phospholipid-translocating ATPase activity
0.64	GO:0000287	magnesium ion binding
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding

0.78	GO:0005802	trans-Golgi network
0.73	GO:0005768	endosome
0.52	GO:0048471	perinuclear region of cytoplasm
0.38	GO:0005886	plasma membrane
0.35	GO:0044433	cytoplasmic vesicle part
0.35	GO:0098805	whole membrane
0.35	GO:0098588	bounding membrane of organelle
0.30	GO:0031224	intrinsic component of membrane

0.79

GO:0004012

sp|O75112|LDB3_HUMAN
LIM domain-binding protein 3
Search

LDB3

0.89	LIM domain binding 3 transcript variant 8

0.58	GO:0045214	sarcomere organization
0.44	GO:0001756	somitogenesis
0.43	GO:0007519	skeletal muscle tissue development
0.43	GO:0007626	locomotory behavior
0.42	GO:0007507	heart development

0.60	GO:0051371	muscle alpha-actinin binding
0.59	GO:0005080	protein kinase C binding
0.53	GO:0046872	metal ion binding

0.58	GO:0030018	Z disc
0.49	GO:0005856	cytoskeleton
0.40	GO:0031143	pseudopodium
0.38	GO:0048471	perinuclear region of cytoplasm

sp|O75113|N4BP1_HUMAN
NEDD4-binding protein 1
Search

N4BP1

0.75	NEDD4-binding protein 1

0.74	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
0.72	GO:0031397	negative regulation of protein ubiquitination
0.69	GO:0034644	cellular response to UV

0.52	GO:0003723	RNA binding
0.46	GO:0005515	protein binding

0.72	GO:0016605	PML body
0.63	GO:0005730	nucleolus

sp|O75116|ROCK2_HUMAN
Rho-associated protein kinase 2
Search

ROCK2

0.91	Rho associated coiled-coil containing protein kinase 2

0.85	GO:0010825	positive regulation of centrosome duplication
0.84	GO:0006939	smooth muscle contraction
0.83	GO:0007266	Rho protein signal transduction
0.76	GO:0032956	regulation of actin cytoskeleton organization
0.68	GO:0030036	actin cytoskeleton organization
0.62	GO:0006468	protein phosphorylation
0.61	GO:1903347	negative regulation of bicellular tight junction assembly
0.60	GO:0071394	cellular response to testosterone stimulus
0.60	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity
0.60	GO:1905247	positive regulation of aspartic-type peptidase activity

0.76	GO:0017048	Rho GTPase binding
0.69	GO:0004674	protein serine/threonine kinase activity
0.54	GO:0030554	adenyl nucleotide binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.53	GO:0032555	purine ribonucleotide binding
0.53	GO:0008144	drug binding
0.52	GO:0046872	metal ion binding
0.34	GO:0003723	RNA binding
0.33	GO:0005198	structural molecule activity

0.59	GO:0005856	cytoskeleton
0.54	GO:0036464	cytoplasmic ribonucleoprotein granule
0.49	GO:0005829	cytosol
0.44	GO:0044446	intracellular organelle part
0.41	GO:0005773	vacuole
0.38	GO:0005886	plasma membrane
0.36	GO:0005634	nucleus
0.30	GO:0016021	integral component of membrane

0.69

GO:0004674

sp|O75121|MFA3L_HUMAN
Microfibrillar-associated protein 3-like
Search

MFAP3L

0.96	Microfibril associated protein 3 like

0.34

GO:0005515

protein binding

0.44	GO:0005634	nucleus
0.42	GO:0005886	plasma membrane
0.39	GO:0005737	cytoplasm
0.33	GO:0005576	extracellular region
0.30	GO:0044425	membrane part

sp|O75122|CLAP2_HUMAN
CLIP-associating protein 2
Search

CLASP2

0.88	CLIP-associating protein 2

0.61	GO:1903690	negative regulation of wound healing, spreading of epidermal cells
0.61	GO:1904259	regulation of basement membrane assembly involved in embryonic body morphogenesis
0.61	GO:0090091	positive regulation of extracellular matrix disassembly
0.61	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway
0.60	GO:1901203	positive regulation of extracellular matrix assembly
0.59	GO:0051497	negative regulation of stress fiber assembly
0.59	GO:0051895	negative regulation of focal adhesion assembly
0.59	GO:0010458	exit from mitosis
0.59	GO:0007026	negative regulation of microtubule depolymerization
0.58	GO:0040019	positive regulation of embryonic development

0.59	GO:0002162	dystroglycan binding
0.58	GO:0051010	microtubule plus-end binding
0.57	GO:1990782	protein tyrosine kinase binding
0.54	GO:0051015	actin filament binding

0.72	GO:0005794	Golgi apparatus
0.66	GO:0005829	cytosol
0.62	GO:1903754	cortical microtubule plus-end
0.60	GO:0045180	basal cortex
0.59	GO:0044295	axonal growth cone
0.58	GO:0032587	ruffle membrane
0.56	GO:0005925	focal adhesion
0.55	GO:0072686	mitotic spindle
0.55	GO:0000777	condensed chromosome kinetochore
0.53	GO:0005815	microtubule organizing center

sp|O75123|ZN623_HUMAN
Zinc finger protein 623
Search

0.42	Zinc finger protein 418

0.52	GO:1903506	regulation of nucleic acid-templated transcription
0.52	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.51	GO:0010468	regulation of gene expression
0.39	GO:0006351	transcription, DNA-templated
0.38	GO:1902679	negative regulation of RNA biosynthetic process
0.34	GO:1902680	positive regulation of RNA biosynthetic process

0.51	GO:0003676	nucleic acid binding
0.49	GO:0046872	metal ion binding
0.45	GO:0003700	DNA binding transcription factor activity
0.37	GO:0042802	identical protein binding
0.36	GO:0046982	protein heterodimerization activity

0.42	GO:0005622	intracellular
0.39	GO:0043227	membrane-bounded organelle
0.37	GO:0031974	membrane-enclosed lumen
0.36	GO:0043228	non-membrane-bounded organelle
0.35	GO:0044422	organelle part
0.35	GO:0005886	plasma membrane

sp|O75127|PTCD1_HUMAN
Pentatricopeptide repeat-containing protein 1, mitochondrial
Search

PTCD1

0.88	Pentatricopeptide repeat-containing protein 1

0.77

GO:0042780

tRNA 3'-end processing

0.67

GO:0000049

tRNA binding

0.74	GO:0005759	mitochondrial matrix
0.30	GO:0031224	intrinsic component of membrane

sp|O75128|COBL_HUMAN
Protein cordon-bleu
Search

COBL

0.76	Cordon-bleu WH2 repeat protein

0.70	GO:0051639	actin filament network formation
0.66	GO:0030041	actin filament polymerization
0.63	GO:0048669	collateral sprouting in absence of injury
0.62	GO:0001757	somite specification
0.61	GO:1900029	positive regulation of ruffle assembly
0.61	GO:0033504	floor plate development
0.59	GO:0030903	notochord development
0.59	GO:1900006	positive regulation of dendrite development
0.58	GO:0001843	neural tube closure
0.58	GO:0000578	embryonic axis specification

0.74	GO:0003779	actin binding
0.41	GO:0005057	signal transducer activity, downstream of receptor

0.63	GO:0044294	dendritic growth cone
0.60	GO:0044295	axonal growth cone
0.57	GO:0001726	ruffle
0.57	GO:0005884	actin filament
0.56	GO:0043025	neuronal cell body
0.55	GO:0048471	perinuclear region of cytoplasm
0.53	GO:0005938	cell cortex
0.30	GO:0016020	membrane

sp|O75129|ASTN2_HUMAN
Astrotactin-2
Search

ASTN2

0.33	Astrotactin-2

0.60	GO:0048105	establishment of body hair planar orientation
0.60	GO:2000009	negative regulation of protein localization to cell surface
0.44	GO:0007158	neuron cell-cell adhesion
0.42	GO:0001764	neuron migration
0.42	GO:0007626	locomotory behavior
0.36	GO:0015031	protein transport

0.63	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding
0.50	GO:0005509	calcium ion binding
0.34	GO:0005515	protein binding

0.60	GO:0060187	cell pole
0.55	GO:0005768	endosome
0.42	GO:0009897	external side of plasma membrane
0.39	GO:0043204	perikaryon
0.38	GO:0030136	clathrin-coated vesicle
0.37	GO:0005938	cell cortex
0.30	GO:0031224	intrinsic component of membrane

sp|O75131|CPNE3_HUMAN
Copine-3
Search

CPNE3

0.96	Copine III

0.86	GO:0038128	ERBB2 signaling pathway
0.84	GO:0071277	cellular response to calcium ion
0.78	GO:0030335	positive regulation of cell migration
0.77	GO:0071363	cellular response to growth factor stimulus
0.61	GO:0006468	protein phosphorylation
0.40	GO:0043312	neutrophil degranulation
0.38	GO:0046474	glycerophospholipid biosynthetic process

0.84	GO:0048306	calcium-dependent protein binding
0.82	GO:0030971	receptor tyrosine kinase binding
0.79	GO:0005544	calcium-dependent phospholipid binding
0.68	GO:0004674	protein serine/threonine kinase activity
0.37	GO:0003723	RNA binding
0.35	GO:0005215	transporter activity

0.79	GO:0005925	focal adhesion
0.72	GO:0005730	nucleolus
0.67	GO:0005829	cytosol
0.60	GO:0005739	mitochondrion
0.54	GO:0005886	plasma membrane
0.42	GO:0070062	extracellular exosome
0.41	GO:0035577	azurophil granule membrane
0.38	GO:0031965	nuclear membrane
0.36	GO:0005654	nucleoplasm
0.30	GO:0031224	intrinsic component of membrane

0.68

GO:0004674

sp|O75132|ZBED4_HUMAN
Zinc finger BED domain-containing protein 4
Search

0.54	Zinc finger BED domain-containing protein 4

0.30	GO:0051252	regulation of RNA metabolic process
0.30	GO:0031326	regulation of cellular biosynthetic process
0.30	GO:0010556	regulation of macromolecule biosynthetic process
0.30	GO:0010468	regulation of gene expression

0.68	GO:0046983	protein dimerization activity
0.55	GO:0003677	DNA binding
0.30	GO:0140110	transcription regulator activity
0.30	GO:0043167	ion binding
0.30	GO:0001067	regulatory region nucleic acid binding

0.30	GO:0005737	cytoplasm
0.30	GO:0044428	nuclear part
0.30	GO:0043233	organelle lumen

sp|O75140|DEPD5_HUMAN
DEP domain-containing protein 5
Search

DEPDC5

0.91	DEP domain-containing protein 5

0.63	GO:0035556	intracellular signal transduction
0.59	GO:0034198	cellular response to amino acid starvation
0.59	GO:1904262	negative regulation of TORC1 signaling
0.54	GO:0043547	positive regulation of GTPase activity
0.45	GO:0010506	regulation of autophagy
0.34	GO:2001141	regulation of RNA biosynthetic process
0.34	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.34	GO:0010468	regulation of gene expression
0.32	GO:0043043	peptide biosynthetic process
0.32	GO:0044267	cellular protein metabolic process

0.54	GO:0005096	GTPase activator activity
0.52	GO:0032403	protein complex binding
0.35	GO:0043565	sequence-specific DNA binding
0.33	GO:0003735	structural constituent of ribosome

0.61	GO:1990130	GATOR1 complex
0.57	GO:0005765	lysosomal membrane
0.55	GO:0048471	perinuclear region of cytoplasm
0.50	GO:0005829	cytosol
0.35	GO:0005634	nucleus
0.32	GO:0005840	ribosome

sp|O75143|ATG13_HUMAN
Autophagy-related protein 13
Search

ATG13

0.73	Autophagy-related protein 13

0.77	GO:0006914	autophagy
0.55	GO:0098780	response to mitochondrial depolarisation
0.53	GO:1903955	positive regulation of protein targeting to mitochondrion
0.53	GO:0061726	mitochondrion disassembly
0.52	GO:0007033	vacuole organization
0.48	GO:0070925	organelle assembly
0.36	GO:0016241	regulation of macroautophagy

0.51

GO:0019901

protein kinase binding

0.84	GO:1990316	Atg1/ULK1 kinase complex
0.53	GO:0000407	phagophore assembly site
0.47	GO:0005829	cytosol
0.43	GO:0005739	mitochondrion
0.35	GO:0005789	endoplasmic reticulum membrane

sp|O75144|ICOSL_HUMAN
ICOS ligand
Search

ICOSLG

0.87	Inducible T-cell co-stimulator ligand

0.44	GO:0042104	positive regulation of activated T cell proliferation
0.44	GO:0031295	T cell costimulation
0.43	GO:0006972	hyperosmotic response
0.42	GO:0042113	B cell activation
0.42	GO:0042110	T cell activation
0.42	GO:0002250	adaptive immune response
0.40	GO:0045404	positive regulation of interleukin-4 biosynthetic process
0.40	GO:0006952	defense response
0.37	GO:0007165	signal transduction

0.40

GO:0005102

receptor binding

0.49	GO:0036464	cytoplasmic ribonucleoprotein granule
0.44	GO:0070062	extracellular exosome
0.41	GO:0005886	plasma membrane
0.37	GO:0009986	cell surface
0.37	GO:0098552	side of membrane
0.30	GO:0016021	integral component of membrane

sp|O75145|LIPA3_HUMAN
Liprin-alpha-3
Search

PPFIA3

0.89	PTPRF interacting protein alpha 3

0.81	GO:0099643	signal release from synapse
0.81	GO:0099531	presynaptic process involved in chemical synaptic transmission
0.75	GO:0006836	neurotransmitter transport
0.71	GO:0001505	regulation of neurotransmitter levels
0.68	GO:0051649	establishment of localization in cell
0.41	GO:0048172	regulation of short-term neuronal synaptic plasticity
0.40	GO:0001944	vasculature development
0.37	GO:0014047	glutamate secretion
0.35	GO:0051497	negative regulation of stress fiber assembly
0.35	GO:1903077	negative regulation of protein localization to plasma membrane

0.35

GO:0005515

protein binding

0.83	GO:0048786	presynaptic active zone
0.53	GO:0001669	acrosomal vesicle
0.42	GO:0098875	epididymosome
0.35	GO:0005829	cytosol
0.34	GO:0005925	focal adhesion
0.30	GO:0016020	membrane

sp|O75146|HIP1R_HUMAN
Huntingtin-interacting protein 1-related protein
Search

HIP1R

0.93	Huntingtin interacting protein 1 related b

0.78	GO:0006915	apoptotic process
0.74	GO:2000588	positive regulation of platelet-derived growth factor receptor-beta signaling pathway
0.73	GO:1905443	regulation of clathrin coat assembly
0.73	GO:0072583	clathrin-dependent endocytosis
0.71	GO:0060453	regulation of gastric acid secretion
0.71	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
0.70	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
0.68	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
0.67	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation
0.67	GO:0032092	positive regulation of protein binding

0.81	GO:0030276	clathrin binding
0.77	GO:0035091	phosphatidylinositol binding
0.74	GO:0003779	actin binding
0.66	GO:0098748	endocytic adaptor activity
0.62	GO:0017124	SH3 domain binding
0.61	GO:0042803	protein homodimerization activity
0.61	GO:0032403	protein complex binding
0.60	GO:0046982	protein heterodimerization activity

0.80	GO:0005905	clathrin-coated pit
0.80	GO:0030136	clathrin-coated vesicle
0.67	GO:0032587	ruffle membrane
0.63	GO:0016324	apical plasma membrane
0.62	GO:0048471	perinuclear region of cytoplasm
0.60	GO:0005938	cell cortex
0.55	GO:0005856	cytoskeleton
0.55	GO:0005829	cytosol
0.50	GO:0005739	mitochondrion
0.40	GO:0044456	synapse part

sp|O75147|OBSL1_HUMAN
Obscurin-like protein 1
Search

0.72	obscurin-like protein 1

0.30	GO:0043687	post-translational protein modification
0.30	GO:0008104	protein localization
0.30	GO:0050769	positive regulation of neurogenesis
0.30	GO:0000226	microtubule cytoskeleton organization
0.30	GO:0006936	muscle contraction
0.30	GO:0097435	supramolecular fiber organization
0.30	GO:0032989	cellular component morphogenesis
0.30	GO:0048738	cardiac muscle tissue development
0.30	GO:0007088	regulation of mitotic nuclear division
0.30	GO:0050773	regulation of dendrite development

0.30	GO:0051371	muscle alpha-actinin binding
0.30	GO:0030674	protein binding, bridging
0.30	GO:0032403	protein complex binding
0.30	GO:0008307	structural constituent of muscle
0.30	GO:0097493	structural molecule activity conferring elasticity
0.30	GO:0003779	actin binding

0.30	GO:0044449	contractile fiber part
0.30	GO:0043234	protein complex
0.30	GO:0014704	intercalated disc
0.30	GO:0030016	myofibril
0.30	GO:0043231	intracellular membrane-bounded organelle
0.30	GO:0005813	centrosome
0.30	GO:0012505	endomembrane system
0.30	GO:0048471	perinuclear region of cytoplasm
0.30	GO:0015629	actin cytoskeleton
0.30	GO:0005829	cytosol

sp|O75150|BRE1B_HUMAN
E3 ubiquitin-protein ligase BRE1B
Search

RNF40

0.53	Ring finger protein 40

0.85	GO:0010390	histone monoubiquitination
0.67	GO:2001168	positive regulation of histone H2B ubiquitination
0.66	GO:1900364	negative regulation of mRNA polyadenylation
0.65	GO:0033523	histone H2B ubiquitination
0.44	GO:0031062	positive regulation of histone methylation
0.44	GO:0006511	ubiquitin-dependent protein catabolic process
0.44	GO:0030336	negative regulation of cell migration
0.43	GO:0000209	protein polyubiquitination
0.42	GO:1902916	positive regulation of protein polyubiquitination
0.41	GO:0045893	positive regulation of transcription, DNA-templated

0.74	GO:0004842	ubiquitin-protein transferase activity
0.62	GO:0003730	mRNA 3'-UTR binding
0.60	GO:0031625	ubiquitin protein ligase binding
0.55	GO:0042803	protein homodimerization activity
0.51	GO:0016874	ligase activity
0.44	GO:0002039	p53 binding
0.43	GO:0042393	histone binding
0.43	GO:0003713	transcription coactivator activity
0.42	GO:0003682	chromatin binding
0.42	GO:0017075	syntaxin-1 binding

0.66	GO:0033503	HULC complex
0.54	GO:0005654	nucleoplasm
0.41	GO:0005730	nucleolus
0.41	GO:0043679	axon terminus
0.39	GO:0019898	extrinsic component of membrane
0.38	GO:0005829	cytosol
0.30	GO:0016021	integral component of membrane

0.51	EC:6	GO:0016874
0.74	KEGG:R03876	GO:0004842

sp|O75151|PHF2_HUMAN
Lysine-specific demethylase PHF2
Search

PHF2

0.90	Lysine-specific demethylase PHF2

0.60	GO:0032259	methylation
0.48	GO:0033169	histone H3-K9 demethylation
0.47	GO:0061188	negative regulation of chromatin silencing at rDNA
0.41	GO:0001889	liver development
0.39	GO:0006351	transcription, DNA-templated
0.37	GO:0055114	oxidation-reduction process

0.61	GO:0008168	methyltransferase activity
0.51	GO:0046872	metal ion binding
0.48	GO:0032454	histone demethylase activity (H3-K9 specific)
0.46	GO:0035064	methylated histone binding
0.45	GO:0003713	transcription coactivator activity
0.42	GO:0051213	dioxygenase activity

0.57	GO:0005634	nucleus
0.45	GO:0000777	condensed chromosome kinetochore
0.41	GO:0031974	membrane-enclosed lumen

0.61

GO:0008168

sp|O75152|ZC11A_HUMAN
Zinc finger CCCH domain-containing protein 11A
Search

ZC3H11A

0.77	Zinc finger CCCH domain-containing protein 11A

0.44	GO:0016973	poly(A)+ mRNA export from nucleus
0.30	GO:0006369	termination of RNA polymerase II transcription
0.30	GO:0016071	mRNA metabolic process
0.30	GO:0006396	RNA processing

0.54	GO:0046872	metal ion binding
0.36	GO:0003723	RNA binding
0.30	GO:0005515	protein binding

0.44	GO:0000346	transcription export complex
0.30	GO:0031974	membrane-enclosed lumen

sp|O75153|CLU_HUMAN
Clustered mitochondria protein homolog
Search

CLUH

0.79	Clustered mitochondria protein homolog

0.85	GO:0048312	intracellular distribution of mitochondria
0.35	GO:0006413	translational initiation

0.55	GO:0003723	RNA binding
0.33	GO:0003735	structural constituent of ribosome

0.48	GO:0005737	cytoplasm
0.33	GO:1990904	ribonucleoprotein complex
0.33	GO:0043232	intracellular non-membrane-bounded organelle
0.30	GO:0044425	membrane part

sp|O75154|RFIP3_HUMAN
Rab11 family-interacting protein 3
Search

RAB11FIP3

0.90	RAB11 family interacting protein 3 (Class II)

0.84	GO:0032456	endocytic recycling
0.72	GO:0000910	cytokinesis
0.60	GO:0070164	negative regulation of adiponectin secretion
0.53	GO:0032465	regulation of cytokinesis
0.41	GO:0061512	protein localization to cilium

0.86	GO:0030306	ADP-ribosylation factor binding
0.81	GO:0017137	Rab GTPase binding
0.60	GO:0005509	calcium ion binding
0.57	GO:0051959	dynein light intermediate chain binding
0.51	GO:0042803	protein homodimerization activity

0.56	GO:0032154	cleavage furrow
0.56	GO:0045171	intercellular bridge
0.55	GO:0030496	midbody
0.55	GO:0055037	recycling endosome
0.53	GO:0005813	centrosome
0.49	GO:0005654	nucleoplasm
0.41	GO:0010008	endosome membrane
0.37	GO:0005829	cytosol
0.30	GO:0031224	intrinsic component of membrane

sp|O75155|CAND2_HUMAN
Cullin-associated NEDD8-dissociated protein 2
Search

CAND2

0.86	Cullin-associated and neddylation-dissociated protein 1

0.82	GO:0010265	SCF complex assembly
0.65	GO:0016567	protein ubiquitination
0.57	GO:0043086	negative regulation of catalytic activity
0.57	GO:0030154	cell differentiation
0.43	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
0.38	GO:0043312	neutrophil degranulation
0.37	GO:0043687	post-translational protein modification
0.36	GO:0006879	cellular iron ion homeostasis
0.36	GO:0006351	transcription, DNA-templated
0.34	GO:0006518	peptide metabolic process

0.68	GO:0017025	TBP-class protein binding
0.36	GO:0032550	purine ribonucleoside binding
0.36	GO:0019001	guanyl nucleotide binding
0.35	GO:0003735	structural constituent of ribosome
0.34	GO:0032555	purine ribonucleotide binding
0.34	GO:0035639	purine ribonucleoside triphosphate binding

0.61	GO:0005634	nucleus
0.61	GO:0031461	cullin-RING ubiquitin ligase complex
0.56	GO:0005794	Golgi apparatus
0.54	GO:0005829	cytosol
0.54	GO:0043233	organelle lumen
0.47	GO:0044446	intracellular organelle part
0.40	GO:0070062	extracellular exosome
0.38	GO:0101002	ficolin-1-rich granule
0.34	GO:0005840	ribosome
0.30	GO:0016020	membrane

sp|O75157|T22D2_HUMAN
TSC22 domain family protein 2
Search

TSC22D2

0.94	Similar to TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4)

0.63	GO:0006970	response to osmotic stress
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:0010468	regulation of gene expression

0.61

GO:0003700

DNA binding transcription factor activity

0.42	GO:0005634	nucleus
0.38	GO:0005737	cytoplasm
0.30	GO:0044425	membrane part

sp|O75159|SOCS5_HUMAN
Suppressor of cytokine signaling 5
Search

SOCS5

0.95	Suppressor of cytokine signaling 5

0.83	GO:0007173	epidermal growth factor receptor signaling pathway
0.82	GO:0007259	JAK-STAT cascade
0.82	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
0.68	GO:0016567	protein ubiquitination
0.61	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
0.60	GO:0097699	vascular endothelial cell response to fluid shear stress
0.58	GO:0045629	negative regulation of T-helper 2 cell differentiation
0.58	GO:0045627	positive regulation of T-helper 1 cell differentiation
0.58	GO:0071638	negative regulation of monocyte chemotactic protein-1 production
0.57	GO:0071404	cellular response to low-density lipoprotein particle stimulus

0.57	GO:0030971	receptor tyrosine kinase binding
0.56	GO:0005154	epidermal growth factor receptor binding
0.47	GO:0004860	protein kinase inhibitor activity

0.45

GO:0005622

intracellular

sp|O75161|NPHP4_HUMAN
Nephrocystin-4
Search

NPHP4

0.97	Nephronophthisis 4

0.84	GO:0090090	negative regulation of canonical Wnt signaling pathway
0.62	GO:1903348	positive regulation of bicellular tight junction assembly
0.60	GO:0035845	photoreceptor cell outer segment organization
0.58	GO:0045494	photoreceptor cell maintenance
0.58	GO:0030317	flagellated sperm motility
0.57	GO:0060041	retina development in camera-type eye
0.42	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway
0.42	GO:0035844	cloaca development
0.42	GO:0072114	pronephros morphogenesis
0.42	GO:0035469	determination of pancreatic left/right asymmetry

0.37	GO:0005515	protein binding
0.34	GO:0005198	structural molecule activity

0.83	GO:0097730	non-motile cilium
0.69	GO:0005856	cytoskeleton
0.61	GO:0097470	ribbon synapse
0.59	GO:0097546	ciliary base
0.57	GO:0035869	ciliary transition zone
0.54	GO:0043005	neuron projection
0.53	GO:0005911	cell-cell junction
0.44	GO:0044446	intracellular organelle part
0.40	GO:0005737	cytoplasm
0.34	GO:0005634	nucleus

sp|O75164|KDM4A_HUMAN
Lysine-specific demethylase 4A
Search

KDM4A

0.91	LOW QUALITY PROTEIN: lysine-specific demethylase 4A

0.61	GO:1900113	negative regulation of histone H3-K9 trimethylation
0.60	GO:0070544	histone H3-K36 demethylation
0.60	GO:0033169	histone H3-K9 demethylation
0.59	GO:0003299	muscle hypertrophy in response to stress
0.59	GO:0014887	cardiac muscle adaptation
0.59	GO:0003300	cardiac muscle hypertrophy
0.52	GO:0010507	negative regulation of autophagy
0.51	GO:0032259	methylation
0.51	GO:0045892	negative regulation of transcription, DNA-templated
0.42	GO:0048712	negative regulation of astrocyte differentiation

0.61	GO:0032454	histone demethylase activity (H3-K9 specific)
0.60	GO:0051864	histone demethylase activity (H3-K36 specific)
0.57	GO:0035064	methylated histone binding
0.54	GO:0031625	ubiquitin protein ligase binding
0.53	GO:0046872	metal ion binding
0.51	GO:0008168	methyltransferase activity
0.38	GO:0004725	protein tyrosine phosphatase activity
0.36	GO:0050681	androgen receptor binding

0.61	GO:0005634	nucleus
0.57	GO:0005721	pericentric heterochromatin
0.49	GO:0005829	cytosol
0.49	GO:0031974	membrane-enclosed lumen
0.30	GO:0031224	intrinsic component of membrane

0.60

EC:1.14.11.27

GO:0051864

sp|O75165|DJC13_HUMAN
DnaJ homolog subfamily C member 13
Search

DNAJC13

0.94	DnaJ like protein subfamily C member 13

0.86	GO:1902954	regulation of early endosome to recycling endosome transport
0.85	GO:2000641	regulation of early endosome to late endosome transport
0.80	GO:0007032	endosome organization
0.64	GO:0045022	early endosome to late endosome transport
0.55	GO:0006898	receptor-mediated endocytosis
0.43	GO:0001649	osteoblast differentiation
0.40	GO:0043312	neutrophil degranulation
0.36	GO:0015031	protein transport

0.36

GO:0005515

protein binding

0.81	GO:0031901	early endosome membrane
0.79	GO:0071203	WASH complex
0.68	GO:0005829	cytosol
0.54	GO:0043231	intracellular membrane-bounded organelle
0.42	GO:0070062	extracellular exosome
0.40	GO:0030667	secretory granule membrane
0.35	GO:0005886	plasma membrane
0.30	GO:0031224	intrinsic component of membrane

sp|O75167|PHAR2_HUMAN
Phosphatase and actin regulator 2
Search

PHACTR2

0.76	Phosphatase and actin regulator

0.82	GO:0032515	negative regulation of phosphoprotein phosphatase activity
0.37	GO:0002576	platelet degranulation
0.33	GO:0007018	microtubule-based movement

0.83	GO:0004864	protein phosphatase inhibitor activity
0.73	GO:0003779	actin binding
0.33	GO:0003777	microtubule motor activity
0.33	GO:0008017	microtubule binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding
0.32	GO:0035639	purine ribonucleoside triphosphate binding

0.37	GO:0031092	platelet alpha granule membrane
0.33	GO:0005886	plasma membrane

sp|O75170|PP6R2_HUMAN
Serine/threonine-protein phosphatase 6 regulatory subunit 2
Search

PPP6R2

0.89	LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 6 regulatory subunit 2

0.38

GO:0043666

regulation of phosphoprotein phosphatase activity

0.40

GO:0005515

protein binding

0.68	GO:0005829	cytosol
0.55	GO:0043231	intracellular membrane-bounded organelle

sp|O75173|ATS4_HUMAN
A disintegrin and metalloproteinase with thrombospondin motifs 4
Search

ADAMTS4

0.91	A disintegrin and metalloproteinase with thrombospondin motifs 4

0.61	GO:0006508	proteolysis
0.60	GO:0007229	integrin-mediated signaling pathway
0.50	GO:0001542	ovulation from ovarian follicle
0.49	GO:0060347	heart trabecula formation
0.47	GO:0001822	kidney development
0.37	GO:0044691	tooth eruption
0.36	GO:0042742	defense response to bacterium
0.36	GO:0022617	extracellular matrix disassembly
0.35	GO:0001501	skeletal system development
0.34	GO:2000026	regulation of multicellular organismal development

0.70	GO:0004222	metalloendopeptidase activity
0.58	GO:0002020	protease binding
0.54	GO:0046872	metal ion binding
0.47	GO:0008201	heparin binding

0.65	GO:0005576	extracellular region
0.55	GO:0016607	nuclear speck
0.44	GO:0031410	cytoplasmic vesicle
0.30	GO:0031224	intrinsic component of membrane

0.70

GO:0004222

sp|O75175|CNOT3_HUMAN
CCR4-NOT transcription complex subunit 3
Search

CNOT3

0.83	CCR4-NOT transcription complex subunit 3

0.60	GO:2000036	regulation of stem cell population maintenance
0.59	GO:0001829	trophectodermal cell differentiation
0.56	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.47	GO:0034249	negative regulation of cellular amide metabolic process
0.45	GO:0006401	RNA catabolic process
0.45	GO:0032269	negative regulation of cellular protein metabolic process
0.45	GO:0010558	negative regulation of macromolecule biosynthetic process
0.45	GO:0031327	negative regulation of cellular biosynthetic process

0.35

GO:0005515

protein binding

0.82	GO:0030015	CCR4-NOT core complex
0.60	GO:0005634	nucleus
0.57	GO:0000932	P-body
0.35	GO:0005829	cytosol

sp|O75177|CREST_HUMAN
Calcium-responsive transactivator
Search

SS18L1

0.97	Calcium-responsive transcription coactivator

0.58	GO:0050775	positive regulation of dendrite morphogenesis
0.57	GO:1903506	regulation of nucleic acid-templated transcription
0.56	GO:0016358	dendrite development
0.45	GO:0097150	neuronal stem cell population maintenance
0.44	GO:0048013	ephrin receptor signaling pathway
0.43	GO:1902680	positive regulation of RNA biosynthetic process
0.43	GO:0010628	positive regulation of gene expression
0.42	GO:0000226	microtubule cytoskeleton organization
0.41	GO:0000902	cell morphogenesis
0.40	GO:0042493	response to drug

0.79	GO:0003713	transcription coactivator activity
0.35	GO:0005515	protein binding
0.34	GO:0032550	purine ribonucleoside binding
0.34	GO:0032561	guanyl ribonucleotide binding
0.34	GO:0003924	GTPase activity
0.33	GO:0000287	magnesium ion binding
0.33	GO:0003700	DNA binding transcription factor activity
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.33	GO:0003677	DNA binding

0.56	GO:0071565	nBAF complex
0.54	GO:0000780	condensed nuclear chromosome, centromeric region
0.53	GO:0000776	kinetochore
0.48	GO:0005829	cytosol
0.44	GO:0071564	npBAF complex
0.44	GO:0005881	cytoplasmic microtubule
0.38	GO:0016604	nuclear body
0.30	GO:0016021	integral component of membrane

sp|O75179|ANR17_HUMAN
Ankyrin repeat domain-containing protein 17
Search

ANKRD17

0.84	Ankyrin repeat and KH domain-containing protein 1

0.64	GO:1900245	positive regulation of MDA-5 signaling pathway
0.63	GO:1900246	positive regulation of RIG-I signaling pathway
0.63	GO:0051151	negative regulation of smooth muscle cell differentiation
0.62	GO:0001955	blood vessel maturation
0.61	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
0.59	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
0.58	GO:0045087	innate immune response
0.56	GO:0042742	defense response to bacterium
0.55	GO:0006275	regulation of DNA replication
0.37	GO:0007492	endoderm development

0.59	GO:0003723	RNA binding
0.55	GO:0003682	chromatin binding
0.34	GO:0005515	protein binding

0.57	GO:0031965	nuclear membrane
0.53	GO:0000785	chromatin
0.41	GO:0005737	cytoplasm
0.30	GO:0016021	integral component of membrane

sp|O75182|SIN3B_HUMAN
Paired amphipathic helix protein Sin3b
Search

SIN3B

0.82	Paired amphipathic helix protein Sin3b

0.57	GO:2001141	regulation of RNA biosynthetic process
0.57	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.56	GO:0010468	regulation of gene expression
0.41	GO:0051253	negative regulation of RNA metabolic process
0.41	GO:0010558	negative regulation of macromolecule biosynthetic process
0.41	GO:0031327	negative regulation of cellular biosynthetic process
0.41	GO:0006476	protein deacetylation
0.39	GO:0019216	regulation of lipid metabolic process
0.39	GO:0016570	histone modification
0.38	GO:1901675	negative regulation of histone H3-K27 acetylation

0.44	GO:0003714	transcription corepressor activity
0.42	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding
0.41	GO:0003682	chromatin binding
0.41	GO:0033558	protein deacetylase activity
0.41	GO:0001104	RNA polymerase II transcription cofactor activity
0.38	GO:0005261	cation channel activity
0.38	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
0.37	GO:0005515	protein binding
0.36	GO:0000976	transcription regulatory region sequence-specific DNA binding
0.34	GO:0003700	DNA binding transcription factor activity

0.61	GO:0005634	nucleus
0.43	GO:0000806	Y chromosome
0.43	GO:0030849	autosome
0.43	GO:0000805	X chromosome
0.43	GO:0001741	XY body
0.41	GO:0000785	chromatin
0.40	GO:0070013	intracellular organelle lumen
0.38	GO:1902494	catalytic complex
0.36	GO:0017053	transcriptional repressor complex
0.36	GO:0000776	kinetochore

0.38

EC:3.5.1

GO:0016811

sp|O75185|AT2C2_HUMAN
Calcium-transporting ATPase type 2C member 2
Search

ATP2C2

0.53	Calcium-transporting ATPase

0.76	GO:0070588	calcium ion transmembrane transport
0.68	GO:0099132	ATP hydrolysis coupled cation transmembrane transport
0.53	GO:0090280	positive regulation of calcium ion import
0.51	GO:0072659	protein localization to plasma membrane
0.50	GO:0061180	mammary gland epithelium development
0.47	GO:0032472	Golgi calcium ion transport
0.47	GO:0032468	Golgi calcium ion homeostasis
0.45	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
0.44	GO:0008544	epidermis development
0.42	GO:0031532	actin cytoskeleton reorganization

0.79	GO:0005388	calcium-transporting ATPase activity
0.54	GO:0032559	adenyl ribonucleotide binding
0.53	GO:0008144	drug binding
0.53	GO:0035639	purine ribonucleoside triphosphate binding
0.38	GO:0015410	manganese-transporting ATPase activity
0.36	GO:0030414	peptidase inhibitor activity
0.35	GO:0030145	manganese ion binding
0.35	GO:0005509	calcium ion binding
0.34	GO:0004871	signal transducer activity
0.34	GO:0005515	protein binding

0.49	GO:0048471	perinuclear region of cytoplasm
0.48	GO:0009898	cytoplasmic side of plasma membrane
0.47	GO:0031410	cytoplasmic vesicle
0.43	GO:0005802	trans-Golgi network
0.42	GO:0000139	Golgi membrane
0.35	GO:0005576	extracellular region
0.34	GO:0031985	Golgi cisterna
0.30	GO:0031224	intrinsic component of membrane

0.79

EC:3.6.3.8

GO:0005388

sp|O75190|DNJB6_HUMAN
DnaJ homolog subfamily B member 6
Search

DNAJB6

0.79	DnaJ homolog subfamily B member 6 isoform a

0.78	GO:0090084	negative regulation of inclusion body assembly
0.76	GO:0045109	intermediate filament organization
0.73	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
0.70	GO:0032781	positive regulation of ATPase activity
0.70	GO:0060715	syncytiotrophoblast cell differentiation involved in labyrinthine layer development
0.67	GO:0060710	chorio-allantoic fusion
0.67	GO:0060717	chorion development
0.65	GO:0032880	regulation of protein localization
0.60	GO:0006457	protein folding
0.60	GO:0030198	extracellular matrix organization

0.70	GO:0001671	ATPase activator activity
0.67	GO:0031072	heat shock protein binding
0.67	GO:0051087	chaperone binding
0.62	GO:0051082	unfolded protein binding
0.48	GO:0042802	identical protein binding
0.45	GO:0003677	DNA binding
0.43	GO:0044183	protein binding involved in protein folding
0.34	GO:0003735	structural constituent of ribosome

0.79	GO:0030018	Z disc
0.75	GO:0048471	perinuclear region of cytoplasm
0.61	GO:0005654	nucleoplasm
0.60	GO:0005829	cytosol
0.34	GO:0005840	ribosome
0.30	GO:0016020	membrane

sp|O75191|XYLB_HUMAN
Xylulose kinase
Search

XYLB

0.48	Xylulose kinase

0.60	GO:0005975	carbohydrate metabolic process
0.53	GO:0016310	phosphorylation
0.42	GO:0044281	small molecule metabolic process
0.36	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
0.35	GO:1901159	xylulose 5-phosphate biosynthetic process
0.34	GO:0036211	protein modification process
0.33	GO:0044248	cellular catabolic process
0.33	GO:1901575	organic substance catabolic process
0.33	GO:0044267	cellular protein metabolic process
0.33	GO:0006091	generation of precursor metabolites and energy

0.62	GO:0016773	phosphotransferase activity, alcohol group as acceptor
0.56	GO:0016301	kinase activity
0.36	GO:0032559	adenyl ribonucleotide binding
0.36	GO:0005057	signal transducer activity, downstream of receptor
0.36	GO:0008144	drug binding
0.36	GO:0035639	purine ribonucleoside triphosphate binding
0.35	GO:0004888	transmembrane signaling receptor activity
0.33	GO:0140096	catalytic activity, acting on a protein
0.33	GO:0046872	metal ion binding
0.33	GO:0016788	hydrolase activity, acting on ester bonds

0.37	GO:0070062	extracellular exosome
0.37	GO:0005737	cytoplasm
0.30	GO:0016020	membrane

0.62

GO:0016773

sp|O75192|PX11A_HUMAN
Peroxisomal membrane protein 11A
Search

PEX11A

0.97	Peroxisomal biogenesis factor 11 alpha

0.83	GO:0016559	peroxisome fission
0.69	GO:0044375	regulation of peroxisome size
0.63	GO:0050873	brown fat cell differentiation
0.48	GO:0007165	signal transduction
0.45	GO:0016557	peroxisome membrane biogenesis
0.36	GO:0019216	regulation of lipid metabolic process

0.57

GO:0042803

protein homodimerization activity

0.81	GO:0005779	integral component of peroxisomal membrane
0.48	GO:0043234	protein complex

sp|O75197|LRP5_HUMAN
Low-density lipoprotein receptor-related protein 5
Search

LRP5

0.70	LDL receptor related protein 5

0.54	GO:0060764	cell-cell signaling involved in mammary gland development
0.53	GO:0061304	retinal blood vessel morphogenesis
0.53	GO:0035426	extracellular matrix-cell signaling
0.53	GO:0048539	bone marrow development
0.53	GO:1902262	apoptotic process involved in blood vessel morphogenesis
0.52	GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification
0.52	GO:0033690	positive regulation of osteoblast proliferation
0.52	GO:0002076	osteoblast development
0.52	GO:0060444	branching involved in mammary gland duct morphogenesis
0.51	GO:0002053	positive regulation of mesenchymal cell proliferation

0.52	GO:0071936	coreceptor activity involved in Wnt signaling pathway
0.51	GO:0017147	Wnt-protein binding
0.50	GO:0042813	Wnt-activated receptor activity

0.48	GO:0043235	receptor complex
0.41	GO:0005739	mitochondrion
0.39	GO:0005886	plasma membrane
0.30	GO:0016021	integral component of membrane

sp|O75200|NPIB7_HUMAN
Nuclear pore complex-interacting protein family member B7
Search

0.97	Nuclear pore complex-interacting protein B type

0.34	GO:0051028	mRNA transport
0.33	GO:0015031	protein transport

0.34

GO:0005515

protein binding

0.58	GO:0005654	nucleoplasm
0.39	GO:0005576	extracellular region
0.34	GO:0031965	nuclear membrane
0.34	GO:0005643	nuclear pore
0.30	GO:0044425	membrane part

sp|O75204|TM127_HUMAN
Transmembrane protein 127
Search

TMEM127

0.96	Transmembrane domain-containing protein (Fragment)

0.84	GO:0032007	negative regulation of TOR signaling
0.79	GO:0008285	negative regulation of cell proliferation
0.59	GO:0007032	endosome organization
0.32	GO:0008033	tRNA processing

0.57	GO:0017137	Rab GTPase binding
0.34	GO:0004386	helicase activity
0.33	GO:0032559	adenyl ribonucleotide binding
0.33	GO:0008144	drug binding
0.33	GO:0035639	purine ribonucleoside triphosphate binding
0.32	GO:0003676	nucleic acid binding

0.57	GO:0005769	early endosome
0.44	GO:0005886	plasma membrane
0.34	GO:0019013	viral nucleocapsid
0.33	GO:0030529	intracellular ribonucleoprotein complex
0.32	GO:0005739	mitochondrion
0.30	GO:0016021	integral component of membrane

sp|O75208|COQ9_HUMAN
Ubiquinone biosynthesis protein COQ9, mitochondrial
Search

COQ9

0.71	Ubiquinone biosynthesis protein COQ9-A, mitochondrial

0.75	GO:0006744	ubiquinone biosynthetic process
0.52	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
0.35	GO:0006351	transcription, DNA-templated

0.52	GO:0042803	protein homodimerization activity
0.51	GO:0008289	lipid binding
0.37	GO:0003899	DNA-directed 5'-3' RNA polymerase activity
0.34	GO:0003677	DNA binding

0.46	GO:0005739	mitochondrion
0.41	GO:0019866	organelle inner membrane

0.37

GO:0003899

sp|O75223|GGCT_HUMAN
Gamma-glutamylcyclotransferase
Search

GGCT

0.45	Gamma-glutamylcyclotransferase b

0.41	GO:0001836	release of cytochrome c from mitochondria
0.35	GO:0006750	glutathione biosynthetic process
0.34	GO:0018279	protein N-linked glycosylation via asparagine
0.34	GO:0042981	regulation of apoptotic process
0.34	GO:0015910	peroxisomal long-chain fatty acid import
0.32	GO:0016310	phosphorylation
0.32	GO:1903506	regulation of nucleic acid-templated transcription
0.32	GO:2000112	regulation of cellular macromolecule biosynthetic process
0.32	GO:0010468	regulation of gene expression
0.32	GO:0055085	transmembrane transport

0.81	GO:0003839	gamma-glutamylcyclotransferase activity
0.39	GO:0042803	protein homodimerization activity
0.35	GO:0016829	lyase activity
0.34	GO:0005324	long-chain fatty acid transporter activity
0.33	GO:0016757	transferase activity, transferring glycosyl groups
0.32	GO:0016301	kinase activity
0.32	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
0.32	GO:0046872	metal ion binding
0.32	GO:0032559	adenyl ribonucleotide binding
0.32	GO:0008144	drug binding

0.37	GO:0005829	cytosol
0.37	GO:0070062	extracellular exosome
0.33	GO:0005789	endoplasmic reticulum membrane
0.33	GO:0005777	peroxisome
0.30	GO:0016021	integral component of membrane

0.81

EC:2.3.2.4

GO:0003839

sp|O75251|NDUS7_HUMAN
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Search

NDUFS7

0.90	Mitochondrial NADH dehydrogenase iron-sulfur protein 7

0.53	GO:0032981	mitochondrial respiratory chain complex I assembly
0.52	GO:0055114	oxidation-reduction process
0.36	GO:0006325	chromatin organization
0.35	GO:0033554	cellular response to stress
0.34	GO:0006259	DNA metabolic process
0.34	GO:0010243	response to organonitrogen compound
0.33	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
0.33	GO:0016310	phosphorylation
0.33	GO:0036211	protein modification process
0.33	GO:0046034	ATP metabolic process

0.71	GO:0048038	quinone binding
0.68	GO:0008137	NADH dehydrogenase (ubiquinone) activity
0.66	GO:0051539	4 iron, 4 sulfur cluster binding
0.53	GO:0046872	metal ion binding
0.39	GO:0002020	protease binding
0.37	GO:0031491	nucleosome binding
0.33	GO:0061630	ubiquitin protein ligase activity
0.33	GO:0004672	protein kinase activity
0.32	GO:0030554	adenyl nucleotide binding
0.32	GO:0097367	carbohydrate derivative binding

0.52	GO:0005747	mitochondrial respiratory chain complex I
0.42	GO:0005886	plasma membrane
0.38	GO:0043025	neuronal cell body
0.38	GO:0043005	neuron projection
0.38	GO:0044456	synapse part
0.34	GO:0005634	nucleus
0.34	GO:0005759	mitochondrial matrix
0.34	GO:0000836	Hrd1p ubiquitin ligase complex
0.30	GO:0016021	integral component of membrane

0.68